TY  - JOUR
T1  - The U.S. Mandatory Guidelines for Federal Workplace Drug Testing Programs: current status and future considerations.
AN  - 70194762; 17434274
AB  - The U.S. Department of Health and Human Services (HHS) drug testing standards were published in 1988 and revised in 1994, 1998, and 2004. In 2004, significant revisions defining, standardizing, and requiring specimen validity testing on Federal employee donor urine specimens were included. In a separate notice, HHS proposed to establish scientific and technical guidelines for the Federal Workplace Drug Testing Program to: (1) permit laboratory testing of hair, oral fluid, and sweat patch specimens in addition to urine specimens for marijuana, cocaine, phencyclidine, opiates (with focus on heroin), and amphetamines [including methylenedioxymethamphetamine (MDMA), methylenedioxyethamphetamine (MDEA), methylenedioxyamphetamine (MDA)]; (2) permit use of on-site point of collection test (POCT) devices to test urine and oral fluid at collection sites; (3) permit use of instrumented initial test (screening only) facilities [IITF] to quickly identify negative specimens; and (4) add training requirement for collectors, on-site testers, and MROs. This proposal was published in the Federal Register on 13 April 2004, with a 90-day public comment period. The Substance Abuse and Mental Health Services Administration, HHS, reviewed those comments and is preparing the Final Notice that will define the requirements for such testing, including: specimen collection procedures, custody and control procedures that ensure donor specimen identity and integrity, testing facility, initial and confirmatory test cutoff concentrations, analytical testing methods, result review and reporting, evaluation of alternative medical explanations for presence of drug or metabolite in the donor's specimen, and laboratory certification issues. Voluntary pilot performance testing (PT) programs for each specimen type are on-going since April 2000 to determine how to prepare PT materials for specimens other than urine to evaluate laboratories' ability to routinely achieve accuracy and precision required. Certification programs will be developed using the current urine drug testing National Laboratory Certification Program model. The addition of accurate and reliable workplace drug testing using hair, oral fluid, and sweat patch specimens will complement urine drug testing, and aid in combating industries devoted to suborning drug testing through adulteration, substitution, and dilution. For example, hair testing may detect chronic drug use for up to 90 days and be useful in pre-employment situations; oral fluid testing may detect drug use in past hours and be useful in post-accident situations; sweat patch testing may be useful in follow-up drug testing and treatment programs; POCTs and IITFs may be most useful for quickly identifying specimens that are negative for drugs and indicate that the specimen is valid.
JF  - Forensic science international
AU  - Bush, Donna M
AD  - Division of Workplace Programs, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, One Choke Cherry Road, Room 2-1033, Rockville, MD 20857, USA. Donna.Bush@samhsa.hhs.gov
Y1  - 2008/01/30/
PY  - 2008
DA  - 2008 Jan 30
SP  - 111
EP  - 119
VL  - 174
IS  - 2-3
KW  - Index Medicus
KW  - United States
KW  - Substance-Related Disorders -- diagnosis
KW  - Sweat -- chemistry
KW  - Saliva -- chemistry
KW  - Organizational Policy
KW  - Humans
KW  - Hair -- chemistry
KW  - United States Dept. of Health and Human Services
KW  - Occupational Health Services
KW  - Workplace
KW  - Mandatory Programs
KW  - Substance Abuse Detection -- legislation & jurisprudence
KW  - Substance Abuse Detection -- methods
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Forensic+science+international&rft.atitle=The+U.S.+Mandatory+Guidelines+for+Federal+Workplace+Drug+Testing+Programs%3A+current+status+and+future+considerations.&rft.au=Bush%2C+Donna+M&rft.aulast=Bush&rft.aufirst=Donna&rft.date=2008-01-30&rft.volume=174&rft.issue=2-3&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Forensic+science+international&rft.issn=1872-6283&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-05
N1  - Date created - 2008-01-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - Evaluation of Modern Extraction Methods for the Analysis of Analytes Related to Food Defence
T2  - 10th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers and 10th International Symposium on Advances in Extraction Techniques (HTC - ExTech 10)
AN  - 40686062; 4746495
JF  - 10th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers and 10th International Symposium on Advances in Extraction Techniques (HTC - ExTech 10)
AU  - De Jager, L.S.
AU  - Perfetti, G A
AU  - Begley, T H
AU  - Diachenko, G W
Y1  - 2008/01/28/
PY  - 2008
DA  - 2008 Jan 28
KW  - Food
KW  - U 7000:Multidisciplinary
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L2  - http://www.ordibo.be/htc/index.html
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Survey results of benzene in soft drinks and other beverages by headspace gas chromatography/mass spectrometry.
AN  - 70209758; 18072742
AB  - Benzene, a carcinogen that can cause cancer in humans, may form at nanogram per gram levels in some beverages containing both benzoate salts and ascorbic or erythorbic acids. Through a series of reactions, a hydroxyl radical forms that can decarboxylate benzoate to form benzene. Elevated temperatures and light stimulate these reactions, while sugar and ethylenediaminetetraacetic acid (EDTA) can inhibit them. A headspace gas chromatography/mass spectrometry method for the determination of benzene in beverages was developed and validated. The method was used to conduct a survey of 199 soft drinks and other beverages. The vast majority of beverages sampled contained either no detectable benzene or levels below the U.S. Environmental Protection Agency's drinking water limit of 5 ng/g. Beverages found to contain 5 ng/g benzene or more were reformulated by the manufacturers. The amount of benzene found in the reformulated beverages ranged from none detected to 1.1 ng/g.
JF  - Journal of agricultural and food chemistry
AU  - Nyman, Patricia J
AU  - Diachenko, Gregory W
AU  - Perfetti, Gracia A
AU  - McNeal, Timothy P
AU  - Hiatt, Michael H
AU  - Morehouse, Kim M
AD  - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-706, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Patricia.Nyman@fda.hhs.gov
Y1  - 2008/01/23/
PY  - 2008
DA  - 2008 Jan 23
SP  - 571
EP  - 576
VL  - 56
IS  - 2
SN  - 0021-8561, 0021-8561
KW  - Carcinogens
KW  - 0
KW  - Benzene
KW  - J64922108F
KW  - Index Medicus
KW  - Reproducibility of Results
KW  - Maximum Allowable Concentration
KW  - Carcinogens -- analysis
KW  - Carbonated Beverages -- analysis
KW  - Benzene -- analysis
KW  - Beverages -- analysis
KW  - Gas Chromatography-Mass Spectrometry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-08
N1  - Date created - 2008-01-17
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - Comparison of Cold-adapted and DNA Prime-Adenovirus Boost Vaccines for Induction of Heterosubtypic Immunity to Influenza A Virus
T2  - 2008 Keystone Symposia on Viral Immunity (A5)
AN  - 40721949; 4762565
JF  - 2008 Keystone Symposia on Viral Immunity (A5)
AU  - Epstein, Suzanne L
Y1  - 2008/01/20/
PY  - 2008
DA  - 2008 Jan 20
KW  - Vaccines
KW  - Influenza
KW  - DNA vaccines
KW  - Immunity
KW  - Disease control
KW  - Influenza A virus
KW  - U 2000:Biological Sciences
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.atitle=Comparison+of+Cold-adapted+and+DNA+Prime-Adenovirus+Boost+Vaccines+for+Induction+of+Heterosubtypic+Immunity+to+Influenza+A+Virus&rft.au=Epstein%2C+Suzanne+L&rft.aulast=Epstein&rft.aufirst=Suzanne&rft.date=2008-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.issn=&rft_id=info:doi/
L2  - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 4&subTab=program
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Inactivated influenza vaccine (IIV) in children <2 years of age: examination of selected adverse events reported to the Vaccine Adverse Event Reporting System (VAERS) after thimerosal-free or thimerosal-containing vaccine.
AN  - 70190886; 18093701
AB  - Thimerosal as a preservative (in all but trace amounts) was removed from vaccines used in infants starting in the late 1990s, though the preservative-including inactivated influenza vaccine is still available for use in individuals >or=6 months of age. We compared the proportion of injection site reactions, rash, and infections reported to the Vaccine Adverse Event Reporting System (VAERS) after preservative-free (PFV), preservative-including (PIV), and preservative unknown (PUV) vaccines in reports from 7/1/2004 to 1/4/2006. There were 145, 175, and 216 reports after vaccination with PFV, PIV, and PUV, respectively. The most frequently reported coding terms (fever, rash, and urticaria) were seen in similar proportions in the PFV, PIV, and PUV groups. No difference was detected in the proportion of injection site reactions (ISR), rash, or infections in the PIV, PFV, and PUV reports. Keeping in mind the inherent limitations of VAERS, including underreporting and potential reporting biases, we conclude that there were no substantial differences in the proportion of rash, ISR, and infection reports in the PIV, PFV and PUV reports in infants.
JF  - Vaccine
AU  - McMahon, A W
AU  - Iskander, J K
AU  - Haber, P
AU  - Braun, M M
AU  - Ball, R
AD  - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, USA. ann.mcmahon@fda.hhs.gov
Y1  - 2008/01/17/
PY  - 2008
DA  - 2008 Jan 17
SP  - 427
EP  - 429
VL  - 26
IS  - 3
SN  - 0264-410X, 0264-410X
KW  - Influenza Vaccines
KW  - 0
KW  - Preservatives, Pharmaceutical
KW  - Vaccines, Inactivated
KW  - Thimerosal
KW  - 2225PI3MOV
KW  - Index Medicus
KW  - Infant
KW  - Fever -- etiology
KW  - Adverse Drug Reaction Reporting Systems
KW  - Humans
KW  - Infant, Newborn
KW  - Databases, Factual
KW  - Urticaria -- etiology
KW  - Exanthema -- etiology
KW  - Vaccination
KW  - Child, Preschool
KW  - Thimerosal -- adverse effects
KW  - Thimerosal -- administration & dosage
KW  - Vaccines, Inactivated -- administration & dosage
KW  - Vaccines, Inactivated -- adverse effects
KW  - Influenza Vaccines -- adverse effects
KW  - Preservatives, Pharmaceutical -- adverse effects
KW  - Preservatives, Pharmaceutical -- administration & dosage
KW  - Influenza Vaccines -- administration & dosage
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-31
N1  - Date created - 2008-01-08
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate.
AN  - 70248296; 18223208
AB  - On June 28, 2006, the U.S. Food and Drug Administration approved dasatinib (Sprycel; Bristol-Myers Squibb), a new small-molecule inhibitor of multiple tyrosine kinases, for the treatment of adults with chronic phase, accelerated phase, or myeloid or lymphoid blast phase chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) with resistance or intolerance to prior therapy including imatinib. This summary reviews the database supporting this approval.
          Four single-arm multicenter studies supported the efficacy and safety of dasatinib. The primary efficacy end point in chronic phase CML was major cytogenetic response. The primary end point in accelerated phase, myeloid phase, and lymphoid blast phase CML, and Ph(+) ALL was major hematologic response. The four studies combined enrolled 445 patients. In patients with chronic phase CML, the major cytogenetic response rate was 45% with a complete cytogenetic response rate of 33%. Major hematologic response rates in patients with accelerated phase CML, myeloid CML, lymphoid blast CML, and Ph(+) ALL were 59%, 32%, 31%, and 42%, respectively. Median response durations in chronic phase, accelerated phase, and myeloid phase CML had not been reached. The median durations of major hematologic response were 3.7 months in lymphoid blast CML and 4.8 months in Ph(+) ALL. Common toxicities with dasatinib included myelosuppression, bleeding, and fluid retention.
          This report describes the Food and Drug Administration review supporting the approval of dasatinib for CML and Ph(+) ALL based on the rates and durability of cytogenetic and hematologic responses.
JF  - Clinical cancer research : an official journal of the American Association for Cancer Research
AU  - Brave, Michael
AU  - Goodman, Vicki
AU  - Kaminskas, Edvardas
AU  - Farrell, Ann
AU  - Timmer, William
AU  - Pope, Sarah
AU  - Harapanhalli, Ravi
AU  - Saber, Haleh
AU  - Morse, David
AU  - Bullock, Julie
AU  - Men, Angela
AU  - Noory, Carol
AU  - Ramchandani, Roshni
AU  - Kenna, Leslie
AU  - Booth, Brian
AU  - Gobburu, Joga
AU  - Jiang, Xiaoping
AU  - Sridhara, Rajeshwari
AU  - Justice, Robert
AU  - Pazdur, Richard
AD  - Office of Oncology Drug Products, Office of New Drugs, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA. michael.brave@fda.hhs.gov
Y1  - 2008/01/15/
PY  - 2008
DA  - 2008 Jan 15
SP  - 352
EP  - 359
VL  - 14
IS  - 2
SN  - 1078-0432, 1078-0432
KW  - Antineoplastic Agents
KW  - 0
KW  - Benzamides
KW  - Piperazines
KW  - Protein Kinase Inhibitors
KW  - Pyrimidines
KW  - Thiazoles
KW  - Imatinib Mesylate
KW  - 8A1O1M485B
KW  - Dasatinib
KW  - RBZ1571X5H
KW  - Index Medicus
KW  - United States
KW  - Multicenter Studies as Topic
KW  - Clinical Trials, Phase II as Topic
KW  - Protein Kinase Inhibitors -- pharmacology
KW  - Humans
KW  - Drug Resistance, Neoplasm
KW  - United States Food and Drug Administration
KW  - Protein Kinase Inhibitors -- therapeutic use
KW  - Protein Kinase Inhibitors -- adverse effects
KW  - Clinical Trials, Phase I as Topic
KW  - Drug Approval
KW  - Protein Kinase Inhibitors -- chemistry
KW  - Pyrimidines -- chemistry
KW  - Thiazoles -- chemistry
KW  - Pyrimidines -- adverse effects
KW  - Pyrimidines -- therapeutic use
KW  - Piperazines -- therapeutic use
KW  - Pyrimidines -- pharmacology
KW  - Thiazoles -- adverse effects
KW  - Leukemia, Myeloid, Chronic-Phase -- drug therapy
KW  - Antineoplastic Agents -- adverse effects
KW  - Thiazoles -- pharmacology
KW  - Antineoplastic Agents -- chemistry
KW  - Antineoplastic Agents -- therapeutic use
KW  - Antineoplastic Agents -- pharmacology
KW  - Thiazoles -- therapeutic use
KW  - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-27
N1  - Date created - 2008-01-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1158/1078-0432.CCR-07-4175
ER  - 



TY  - JOUR
T1  - Risk of testicular germ-cell tumours in relation to childhood physical activity
AN  - 20620530; 8074890
AB  - The US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case-control study of testicular germ-cell tumours (TGCTs) enrolled participants and their mothers in 2002-2005. Hours of sports or vigorous childhood physical activity per week were ascertained for three time periods; 1st-5th grades, 6th-8th grades and 9th-12th grades. Son- and mother-reports were analysed separately and included 539 control son-mother pairs and 499 case son-mother pairs. Odds ratios and 95% confidence intervals were produced. The analysis of the sons' responses found no relationship between childhood physical activity and TGCT, while the mothers' analysis found an inverse association, which was solely due to nonseminoma. Future studies should seek to validate responses further using recorded information sources such as school records.
JF  - British Journal of Cancer
AU  - Cook, M B
AU  - Zhang, Y
AU  - Graubard, B I
AU  - Rubertone, M V
AU  - Erickson, R L
AU  - McGlynn, KA
AD  - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS/5005, 6120 Executive Boulevard, Rockville, MD 20892-7234, USA, cookmich@mail.nih.gov
Y1  - 2008/01/15/
PY  - 2008
DA  - 2008 Jan 15
SP  - 174
EP  - 178
VL  - 98
IS  - 1
SN  - 0007-0920, 0007-0920
KW  - Physical Education Index; Risk Abstracts
KW  - Tumors
KW  - Exercise
KW  - Children
KW  - Sports
KW  - Cancer
KW  - Grading
KW  - Schools
KW  - Analysis
KW  - physical activity
KW  - R2 23060:Medical and environmental health
KW  - PE 030:Exercise, Health & Physical Fitness
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Risk+of+testicular+germ-cell+tumours+in+relation+to+childhood+physical+activity&rft.au=Cook%2C+M+B%3BZhang%2C+Y%3BGraubard%2C+B+I%3BRubertone%2C+M+V%3BErickson%2C+R+L%3BMcGlynn%2C+KA&rft.aulast=Cook&rft.aufirst=M&rft.date=2008-01-15&rft.volume=98&rft.issue=1&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604109
LA  - English
DB  - Physical Education Index; ProQuest Environmental Science Collection
N1  - Date revised - 2008-03-01
N1  - Last updated - 2011-12-13
N1  - SubjectsTermNotLitGenreText - Grading; Exercise; Analysis; Tumors; Sports; Schools; Cancer; physical activity; Children
DO  - http://dx.doi.org/10.1038/sj.bjc.6604109
ER  - 



TY  - JOUR
T1  - Toll-free number for reporting adverse events on labeling for human drug products. Interim final rule.
AN  - 70478173; 18389912
AB  - The Food and Drug Administration (FDA) is issuing an interim final rule to codify the provisions of the proposed rule entitled "Toll-Free Number for Reporting Adverse Events on Labeling for Human Drug Products" (69 FR 21778, April 22, 2004) (the toll-free number proposed rule or proposed rule) that, under the Food and Drug Administration Amendments Act of 2007 (FDAAA), became effective by operation of law on January 1, 2008. This interim final rule requires the addition of a statement on the labeling of certain human drug products for which an application is approved under the Federal Food, Drug, and Cosmetic Act (the act). The added statement includes a toll-free number and advises that the number is to be used only for reporting side effects and is not intended for medical advice (the side effects statement). As mandated by FDAAA, this interim final rule does not apply to over-the-counter drug products approved as new drugs under the act if the product packaging includes a manufacturer's or distributor's toll-free number for reporting complaints.
JF  - Federal register
AU  - Food and Drug Administration, HHS
AD  - Food and Drug Administration, HHS
Y1  - 2008/01/03/
PY  - 2008
DA  - 2008 Jan 03
SP  - 402
EP  - 404
VL  - 73
IS  - 2
SN  - 0097-6326, 0097-6326
KW  - Health technology assessment
KW  - United States
KW  - Humans
KW  - Adverse Drug Reaction Reporting Systems -- legislation & jurisprudence
KW  - Drug Labeling -- legislation & jurisprudence
KW  - Hotlines -- legislation & jurisprudence
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Toll-free+number+for+reporting+adverse+events+on+labeling+for+human+drug+products.+Interim+final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2008-01-03&rft.volume=73&rft.issue=2&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-25
N1  - Date created - 2008-04-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD
AN  - 19468490; 7936212
AB  - The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) and its amyloidogenic beta -amyloid (A beta ) product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ( beta -site APP cleaving enzyme 1)] as well as their transcriptional regulator (Sp1) were elevated in aged (23-year-old) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of A beta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD.
JF  - Journal of Neuroscience
AU  - Wu, Jinfang
AU  - Basha, MdRiyaz
AU  - Brock, Brian
AU  - Cox, David P
AU  - Cardozo-Pelaez, Fernando
AU  - McPherson, Christopher A
AU  - Harry, Jean
AU  - Rice, Deborah C
AU  - Maloney, Bryan
AU  - Chen, Demao
AU  - Lahiri, Debomoy K
AU  - Zawia, Nasser H
AD  - Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana 59812, National Institutes of Health, Research Triangle Park, North Carolina 27709, Maine Department of Health and Human Services, Augusta, Maine 04333, and Laboratory for Molecular Neurogenetics, Institute for Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202
Y1  - 2008/01/02/
PY  - 2008
DA  - 2008 Jan 02
SP  - 3
EP  - 9
PB  - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/]
VL  - 28
IS  - 1
SN  - 0270-6474, 0270-6474
KW  - Genetics Abstracts; Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts
KW  - Data processing
KW  - Chromium
KW  - Heavy metals
KW  - Alzheimer's disease
KW  - Brain
KW  - Cortex (frontal)
KW  - Transcription
KW  - Imprinting
KW  - Lead
KW  - Amyloidogenesis
KW  - Amyloid precursor protein
KW  - DNA damage
KW  - Neurodegenerative diseases
KW  - Sp1 protein
KW  - Cortex
KW  - beta -Site APP cleaving enzyme 1
KW  - epigenetics
KW  - Geriatrics
KW  - DNA methyltransferase
KW  - Plaques
KW  - beta -Amyloid
KW  - Secretase
KW  - Infants
KW  - N 14820:DNA Metabolism & Structure
KW  - N3 11028:Neuropharmacology & toxicology
KW  - X 24360:Metals
KW  - G 07730:Development & Cell Cycle
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Alzheimer%27s+Disease+%28AD%29-Like+Pathology+in+Aged+Monkeys+after+Infantile+Exposure+to+Environmental+Metal+Lead+%28Pb%29%3A+Evidence+for+a+Developmental+Origin+and+Environmental+Link+for+AD&rft.au=Wu%2C+Jinfang%3BBasha%2C+MdRiyaz%3BBrock%2C+Brian%3BCox%2C+David+P%3BCardozo-Pelaez%2C+Fernando%3BMcPherson%2C+Christopher+A%3BHarry%2C+Jean%3BRice%2C+Deborah+C%3BMaloney%2C+Bryan%3BChen%2C+Demao%3BLahiri%2C+Debomoy+K%3BZawia%2C+Nasser+H&rft.aulast=Wu&rft.aufirst=Jinfang&rft.date=2008-01-02&rft.volume=28&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Data processing; Chromium; Heavy metals; Alzheimer's disease; Brain; Transcription; Cortex (frontal); Imprinting; Amyloidogenesis; Lead; Amyloid precursor protein; Sp1 protein; Neurodegenerative diseases; DNA damage; Cortex; beta -Site APP cleaving enzyme 1; epigenetics; Geriatrics; DNA methyltransferase; Plaques; Secretase; beta -Amyloid; Infants
ER  - 



TY  - JOUR
T1  - Development of a taxonomy for indexing Web-based mining safety and health research
AN  - 753846500; 2010-075077
JF  - Publication Series - Australasian Institute of Mining and Metallurgy
AU  - Glowacki, A F
A2  - Saydam, Serkan
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 125
EP  - 129
PB  - AusIMM - Australasian Institute of Mining and Metallurgy, Carlton, Victoria
VL  - 10/2008
SN  - 1324-6240, 1324-6240
KW  - occupational safety
KW  - mining legislation
KW  - mining
KW  - safety
KW  - regulations
KW  - data processing
KW  - taxonomy
KW  - computer networks
KW  - research
KW  - information management
KW  - Internet
KW  - 26A:Economic geology, general, deposits
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LA  - English
DB  - GeoRef
N1  - Conference title - Future mining 2008, first international Future mining conference and exhibition 2008
N1  - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Produced under license from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia
N1  - Date revised - 2010-01-01
N1  - Number of references - 27
N1  - PubXState - Victoria
N1  - Document feature - illus. incl. 2 tables
N1  - Last updated - 2012-06-07
N1  - SubjectsTermNotLitGenreText - computer networks; data processing; information management; Internet; mining; mining legislation; occupational safety; regulations; research; safety; taxonomy
ER  - 



TY  - JOUR
T1  - Possible impact of new safety technology developments on the future of the United States mining industry
AN  - 753845073; 2010-075071
JF  - Publication Series - Australasian Institute of Mining and Metallurgy
AU  - Gurtunca, R G
A2  - Saydam, Serkan
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 3
EP  - 9
PB  - AusIMM - Australasian Institute of Mining and Metallurgy, Carlton, Victoria
VL  - 10/2008
SN  - 1324-6240, 1324-6240
KW  - United States
KW  - occupational safety
KW  - mining legislation
KW  - mining
KW  - mines
KW  - explosions
KW  - natural gas
KW  - safety management systems
KW  - legislation
KW  - coal mines
KW  - petroleum
KW  - preventive measures
KW  - new methods
KW  - communication systems
KW  - ventilation
KW  - safety
KW  - future
KW  - coalbed methane
KW  - industry
KW  - coal deposits
KW  - 26A:Economic geology, general, deposits
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Publication+Series+-+Australasian+Institute+of+Mining+and+Metallurgy&rft.atitle=Possible+impact+of+new+safety+technology+developments+on+the+future+of+the+United+States+mining+industry&rft.au=Gurtunca%2C+R+G&rft.aulast=Gurtunca&rft.aufirst=R&rft.date=2008-01-01&rft.volume=10%2F2008&rft.issue=&rft.spage=3&rft.isbn=9781920806927&rft.btitle=&rft.title=Publication+Series+-+Australasian+Institute+of+Mining+and+Metallurgy&rft.issn=13246240&rft_id=info:doi/
LA  - English
DB  - GeoRef
N1  - Conference title - Future mining 2008, first international Future mining conference and exhibition 2008
N1  - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Produced under license from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia
N1  - Date revised - 2010-01-01
N1  - Number of references - 8
N1  - PubXState - Victoria
N1  - Document feature - illus.
N1  - Last updated - 2012-06-07
N1  - SubjectsTermNotLitGenreText - coal deposits; coal mines; coalbed methane; communication systems; explosions; future; industry; legislation; mines; mining; mining legislation; natural gas; new methods; occupational safety; petroleum; preventive measures; safety; safety management systems; United States; ventilation
ER  - 



TY  - JOUR
T1  - Respiratory Disease in Agricultural Workers: Mortality and Morbidity Statistics
AN  - 746162964; 13054597
AB  - To quantify the respiratory disease burden among agricultural workers, we examined the 1988-1998 National Center for Health Statistics (NCHS) "Multiple Cause of Death Data" and the 1988-1994 Third National Health and Nutrition Examination Survey data (NHANES III). Proportionate mortality ratios (PMRs) were determined for 11 respiratory conditions among 6 agricultural groups: crop farm workers, livestock farm workers, farm managers, landscape and horticultural workers, forestry workers, and fishery workers. Prevalence ratios (PRs) were determined for 12 respiratory conditions among 3 agricultural groups: farm workers, farm managers, and other agricultural workers. Disease categories groups were based on the 9th International Classification of Diseases and the agricultural groups on the NCHS or NHANES III industry and occupation codes, respectively. Crop farm workers and livestock farm workers had significantly elevated mortality for several respiratory conditions, with mortality for hypersensitivity pneumonitis being 10 and 50 times higher than expected. Landscape and horticultural workers had significantly elevated mortality for abscess of the lung and mediastinum and chronic airways obstruction. Forestry workers had significantly elevated mortality for pulmonary tuberculosis, chronic airways obstruction, and pneumonia. Prevalence of wheeze was elevated for female farm workers, shortness of breath was elevated for farm workers who had ever smoked, and hay fever was elevated for black, non-Hispanic farm workers. Prevalence of asthma was elevated for other agricultural workers who had ever smoked. Farm workers had a PR of 173 for obstructive respiratory abnormality. Continued improvement in occupational health surveillance systems for agriculture is essential to help guide prevention efforts for respiratory disease.
JF  - Journal of Agromedicine
AU  - Greskevitch, M
AU  - Kullman, G
AU  - Bang, K M
AU  - Mazurek, J M
AD  - Division of Respiratory Disease Studies (DRDS), National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC)
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 5
EP  - 10
VL  - 12
IS  - 3
SN  - 1059-924X, 1059-924X
KW  - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts
KW  - Agriculture
KW  - Statistics
KW  - Farms
KW  - Mycobacterium
KW  - Respiratory diseases
KW  - Nutrition
KW  - Crops
KW  - Morbidity
KW  - Workers
KW  - Classification
KW  - hay fever
KW  - farms
KW  - Fisheries
KW  - prevention
KW  - Tuberculosis
KW  - Forestry
KW  - Respiratory tract
KW  - Mortality
KW  - Data processing
KW  - Landscape
KW  - agriculture
KW  - Asthma
KW  - Abscesses
KW  - Mediastinum
KW  - Livestock
KW  - tuberculosis
KW  - hypersensitivity
KW  - Lung
KW  - classification
KW  - Hay fever
KW  - Pneumonia
KW  - Alveolitis
KW  - Occupational health
KW  - J 02320:Cell Biology
KW  - H 1000:Occupational Safety and Health
KW  - X 24350:Industrial Chemicals
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-06-01
N1  - Last updated - 2015-03-31
N1  - SubjectsTermNotLitGenreText - Agriculture; Mortality; Farms; Statistics; Data processing; Landscape; Asthma; Abscesses; Mediastinum; Nutrition; Morbidity; Crops; Livestock; Workers; Classification; Lung; Fisheries; Tuberculosis; Hay fever; Alveolitis; Pneumonia; Respiratory tract; Forestry; agriculture; Respiratory diseases; tuberculosis; hypersensitivity; hay fever; farms; classification; prevention; Occupational health; Mycobacterium
DO  - http://dx.doi.org/10.1080/10599240701881482
ER  - 



TY  - JOUR
T1  - Respirator Use and Practices in Agricultural Crop Production Establishments
AN  - 746161866; 13054599
AB  - The risk of developing respiratory diseases can be reduced by either wearing respiratory protection under the guidance of an effective respiratory protection program or using controls. In 2001, the Survey of Respirator Use and Practices gathered information on the types of respirators used, respirator use practices, and the respirator program characteristics from 40,002 randomly selected US establishments. This report presents findings of the Survey of Respirator Use and Practices for the Agricultural Production--Crops industry and compares them with National Institute for Occupational Safety and Health (NIOSH) recommendations. Approximately one third of all Agricultural Production--Crops establishments required respirator use. Of the Agricultural Production--Crops establishments that required respirator use, (1) a written program to determine what type of respirator to use was not adopted by management in 73% of the establishments; (2) 21% did not know whether air sampling was conducted for substances for which employees were required to use respirators; (3) 29.5% did not provide respirator training for employees; (4) employees were not assessed for medical fitness to wear a respirator or it was not known whether the employees were assessed, in 49.4%; and (5) the program administrator had received no respirator training in 29.5%. Of the Agricultural Production--Crops establishments that required respirator use, 69.5% had at least 3 indicators of a potentially inadequate respiratory protection program. The high rates of indicators of potential inadequacies suggest widespread problems with respiratory protection programs in the Agricultural Production--Crops industry, indicating a potential for improvement.
JF  - Journal of Agromedicine
AU  - Greskevitch, M
AU  - Doney, B
AU  - Groce, D
AU  - Syamlal, G
AU  - Bang, K M
AD  - National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, USA
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 25
EP  - 31
VL  - 12
IS  - 3
SN  - 1059-924X, 1059-924X
KW  - Health & Safety Science Abstracts
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-06-01
N1  - Last updated - 2011-12-14
DO  - http://dx.doi.org/10.1080/10599240801887801
ER  - 



TY  - JOUR
T1  - Adverse effects of fullerenes on endothelial cells: fullerenol C60(OH)24 induced tissue factor and ICAM-I membrane expression and apoptosis in vitro.
AN  - 70755088; 18488416
AB  - We studied the effects of a C60 water suspension at 4 microg/mL (nC60) and the water soluble fullerenol C60(OH)24 at final concentrations of 1-100 microg/mL on human umbilical vein endothelial cells (HUVECs) in culture. We found that a 24 hr treatment of HUVECs with C60(OH)24 at 100 microg/mL significantly increased cell surface expression of ICAM-1(CD54) (67 +/- 4% CD54+ cells vs. 19 +/- 2 % CD540 cells in control; p < 0.001). In addition, this treatment induced the expression of tissue factor (CD142) on HUVECs (54 +/- 20% CD142+ cells vs 4 +/- 2% CD142+ cells in control; p = 0.008) and increased exposure of phosphatidylserine (PS) (29 +/- 2% PS+ cells vs. 12 +/- 5% PS+ cells in control; p < 0.001). Analysis of cell cycle and DNA fragmentation (TUNEL) showed that both nC60 and C60(OH)24 caused G1 arrest of HUVECs and C60(OH)24 induced significant apoptosis (21 +/- 2% TUNEL+ cells at 100 microg/mL of C60(OH)24 vs. 4 +/- 2% TUNEL+ cells in control; p < 0.001). We also demonstrated that both nC60 and C60(OH)24 induced a rapid concentration dependent elevation of intracellular calcium [Ca2+]i. This could be inhibited by EGTA, suggesting that the source of [Ca2+]i in fullerene stimulated calcium flux is predominantly from the extracellular environment. In conclusion, fullerenol C60(OH)24 had both pro-inflammatory and pro-apoptotic effects on HUVECs, indicating possible adverse effects of fullerenes on the endothelium.
JF  - International journal of nanomedicine
AU  - Gelderman, Monique P
AU  - Simakova, Olga
AU  - Clogston, Jeffrey D
AU  - Patri, Anil K
AU  - Siddiqui, Sheena F
AU  - Vostal, Alexander C
AU  - Simak, Jan
AD  - CBER, FDA, 1401 Rockville Pike, HFM 335, Rockville, MD 20852-1448, USA.
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 59
EP  - 68
VL  - 3
IS  - 1
SN  - 1176-9114, 1176-9114
KW  - Fullerenes
KW  - 0
KW  - Intercellular Adhesion Molecule-1
KW  - 126547-89-5
KW  - fullerenol
KW  - 182024-42-6
KW  - Thromboplastin
KW  - 9035-58-9
KW  - Index Medicus
KW  - Gene Expression -- drug effects
KW  - Cell Survival -- drug effects
KW  - Dose-Response Relationship, Drug
KW  - Cells, Cultured
KW  - Cell Membrane -- drug effects
KW  - Humans
KW  - Apoptosis -- drug effects
KW  - Cell Membrane -- metabolism
KW  - Endothelial Cells -- drug effects
KW  - Endothelial Cells -- cytology
KW  - Thromboplastin -- metabolism
KW  - Fullerenes -- adverse effects
KW  - Intercellular Adhesion Molecule-1 -- metabolism
KW  - Endothelial Cells -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-06-19
N1  - Date created - 2008-05-19
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Cell Mol Life Sci. 2005 May;62(9):971-88 [15761668]
Antimicrob Agents Chemother. 1999 Sep;43(9):2273-7 [10471578]
Biomaterials. 2005 Dec;26(36):7587-95 [16005959]
IEEE Trans Nanobioscience. 2005 Jun;4(2):180-95 [16117026]
Curr Opin Chem Biol. 2005 Dec;9(6):674-9 [16233988]
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Circulation. 2006 Feb 7;113(5):722-31 [16461845]
Toxicol Sci. 2006 May;91(1):173-83 [16476688]
Am J Physiol Cell Physiol. 2006 Jun;290(6):C1495-502 [16407415]
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N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Clostridium difficile: from obscurity to superbug.
AN  - 70737461; 18476496
AB  - According to the UK media and popular press, Clostridium difficile is now a fully fledged member of that notorious but ill-defined group of microorganisms portrayed to the general public as superbugs. Following the trail blazed by methicillin-resistant Staphylococcus aureus (MRSA), C. difficile has made the transition from being an obscure anaerobic bacterium, mainly of interest to specialist anaerobic microbiologists, to that of an infamous superbug responsible for outbreaks of hospital-acquired infection that commonly result in serious disease and death. This review tracks the rise in scientific knowledge and public awareness of this organism.
JF  - British journal of biomedical science
AU  - Brazier, J S
AD  - Anaerobe Reference Laboratory, National Public Health Service for Wales Microbiology, Cardiff, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK. brazier@cardiff.ac.uk
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 39
EP  - 44
VL  - 65
IS  - 1
SN  - 0967-4845, 0967-4845
KW  - Cytotoxins
KW  - 0
KW  - Nucleic Acids
KW  - Index Medicus
KW  - Animals
KW  - Newspapers as Topic
KW  - United Kingdom -- epidemiology
KW  - Molecular Epidemiology
KW  - Guinea Pigs
KW  - Humans
KW  - Nucleic Acids -- genetics
KW  - Cytotoxins -- analysis
KW  - Cricetinae
KW  - Feces -- microbiology
KW  - Enterocolitis, Pseudomembranous -- diagnosis
KW  - Clostridium difficile -- isolation & purification
KW  - Enterocolitis, Pseudomembranous -- epidemiology
KW  - Clostridium difficile -- pathogenicity
KW  - Cross Infection -- epidemiology
KW  - Clostridium difficile -- genetics
KW  - Disease Outbreaks
KW  - Feces -- chemistry
KW  - Enterocolitis, Pseudomembranous -- microbiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70737461?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+biomedical+science&rft.atitle=Clostridium+difficile%3A+from+obscurity+to+superbug.&rft.au=Brazier%2C+J+S&rft.aulast=Brazier&rft.aufirst=J&rft.date=2008-01-01&rft.volume=65&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=British+journal+of+biomedical+science&rft.issn=09674845&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-08-01
N1  - Date created - 2008-05-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Toxicity of kava kava.
AN  - 70373909; 18322868
AB  - Kava is a traditional beverage of various Pacific Basin countries. Kava has been introduced into the mainstream U.S. market principally as an anti-anxiety preparation. The effects of the long-term consumption of kava have not been documented adequately. Preliminary studies suggest possible serious organ system effects. The potential carcinogenicity of kava and its principal constituents are unknown. As such, kava extract was nominated for the chronic tumorigenicity bioassay conducted by the National Toxicology Program (NTP). At present toxicological evaluation of kava extract is being conducted by the NTP. The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity.
JF  - Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
AU  - Fu, Peter P
AU  - Xia, Qingsu
AU  - Guo, Lei
AU  - Yu, Hongtao
AU  - Chan, Po-Chuen
AD  - National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. peter.fu@fda.hhs.gov
PY  - 2008
SP  - 89
EP  - 112
VL  - 26
IS  - 1
KW  - Plant Extracts
KW  - 0
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Drug and Narcotic Control
KW  - Humans
KW  - Cats
KW  - Toxicity Tests
KW  - Dogs
KW  - Rabbits
KW  - Mice
KW  - Liver -- pathology
KW  - Plant Extracts -- metabolism
KW  - Liver -- drug effects
KW  - Plant Extracts -- toxicity
KW  - Plant Extracts -- pharmacokinetics
KW  - Kava -- chemistry
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70373909?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.atitle=Toxicity+of+kava+kava.&rft.au=Fu%2C+Peter+P%3BXia%2C+Qingsu%3BGuo%2C+Lei%3BYu%2C+Hongtao%3BChan%2C+Po-Chuen&rft.aulast=Fu&rft.aufirst=Peter&rft.date=2008-01-01&rft.volume=26&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.issn=1532-4095&rft_id=info:doi/10.1080%2F10590500801907407
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-12
N1  - Date created - 2008-03-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/10590500801907407
ER  - 



TY  - JOUR
T1  - Violent behavior and DSM-IV psychiatric disorders: results from the national epidemiologic survey on alcohol and related conditions.
AN  - 70351342; 18312033
AB  - To present nationally representative data on the lifetime prevalence and population estimates of violent behavior among individuals with DSM-IV psychiatric disorders.
          The data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions. Prevalences, population estimates, and associations of violent behavior occurring among individuals with pure, comorbid, and specific DSM-IV psychiatric disorders were examined. After controlling for sociodemographic characteristics and other comorbidity, it was found that the odds of violent behavior were significantly increased (p < .05) among individuals with substance use disorders; pathological gambling; major depressive disorder; bipolar disorders; panic disorder without agoraphobia; specific phobia; and paranoid, schizoid, histrionic, and obsessive-compulsive personality disorders. Percentages of violent behavior among individuals with each comorbid disorder were, with few exceptions, significantly greater (p < .05-p < .001) than the corresponding percentages among those presenting with the pure form of each disorder. Alcohol and drug use disorders were the most significant contributors to the public health burden of violent behavior.
          The majority of individuals with psychiatric disorders do not engage in violent behavior, and public perception associated with stereotypic violence among individuals with psychiatric disorders appears unwarranted. Elevated risks and burden of violent behavior were not equally shared across the spectrum of psychiatric disorders, with particular disorders, especially substance use disorders, contributing disproportionately to the burden. Future research should examine the circumstances under which violence among individuals with psychiatric disorders occurs with a view toward improving clinical prediction and developing more effective prevention strategies.
JF  - The Journal of clinical psychiatry
AU  - Pulay, Attila J
AU  - Dawson, Deborah A
AU  - Hasin, Deborah S
AU  - Goldstein, Risë B
AU  - Ruan, W June
AU  - Pickering, Roger P
AU  - Huang, Boji
AU  - Chou, S Patricia
AU  - Grant, Bridget F
AD  - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, Md. 20892-9304, USA.
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 12
EP  - 22
VL  - 69
IS  - 1
KW  - Index Medicus
KW  - Severity of Illness Index
KW  - Age Factors
KW  - Alcoholism -- diagnosis
KW  - Humans
KW  - Alcoholism -- psychology
KW  - Ethnic Groups -- psychology
KW  - Ethnic Groups -- statistics & numerical data
KW  - Alcoholism -- epidemiology
KW  - Adult
KW  - Surveys and Questionnaires
KW  - Incidence
KW  - Adolescent
KW  - United States -- epidemiology
KW  - Male
KW  - Diagnostic and Statistical Manual of Mental Disorders
KW  - Female
KW  - Prevalence
KW  - Substance-Related Disorders -- diagnosis
KW  - Mental Disorders -- diagnosis
KW  - Violence -- statistics & numerical data
KW  - Mental Disorders -- epidemiology
KW  - Mental Disorders -- psychology
KW  - Substance-Related Disorders -- psychology
KW  - Violence -- psychology
KW  - Substance-Related Disorders -- epidemiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70351342?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Violent+behavior+and+DSM-IV+psychiatric+disorders%3A+results+from+the+national+epidemiologic+survey+on+alcohol+and+related+conditions.&rft.au=Pulay%2C+Attila+J%3BDawson%2C+Deborah+A%3BHasin%2C+Deborah+S%3BGoldstein%2C+Ris%C3%AB+B%3BRuan%2C+W+June%3BPickering%2C+Roger+P%3BHuang%2C+Boji%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Pulay&rft.aufirst=Attila&rft.date=2008-01-01&rft.volume=69&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-08
N1  - Date created - 2008-03-03
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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Eur Addict Res. 1998 Dec;4(4):144-9 [9852366]
Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S1-6 [9857773]
Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S13-23 [9857775]
Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S55-60 [9857780]
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J Subst Abuse Treat. 2005 Jul;29(1):5-17 [15979527]
Psychiatry Res. 2005 Sep 15;136(2-3):153-62 [16125786]
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J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491]
Addiction. 1999 Jun;94(6):843-55 [10665074]
Am J Drug Alcohol Abuse. 2000 May;26(2):161-77 [10852354]
Arch Gen Psychiatry. 2000 Oct;57(10):979-86 [11015816]
Alcohol Res Health. 2001;25(1):58-65 [11496968]
Alcohol Clin Exp Res. 2003 Feb;27(2):244-52 [12605073]
Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201]
Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279]
J Clin Psychiatry. 2004 Jul;65(7):948-58 [15291684]
Acta Psychiatr Scand Suppl. 2004;(424):5-59 [15447785]
J Psychiatr Res. 2005 Jan;39(1):1-9 [15504418]
Hosp Community Psychiatry. 1990 Jul;41(7):761-70 [2142118]
Am J Psychiatry. 1990 Nov;147(11):1537-41 [2221170]
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Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973]
Epidemiol Rev. 1995;17(1):172-81 [8521935]
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Psychiatry. 1997 Spring;60(1):1-22 [9130311]
Drug Alcohol Depend. 1997 Sep 25;47(3):161-9 [9306042]
Drug Alcohol Depend. 1997 Sep 25;47(3):171-85 [9306043]
Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045]
Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046]
Drug Alcohol Depend. 1997 Sep 25;47(3):217-26 [9306047]
Arch Gen Psychiatry. 1998 May;55(5):393-401 [9596041]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - How useful are voluntary medication error reports? The case of warfarin-related medication errors.
AN  - 70300757; 18277800
AB  - A study was conducted to explore the value and limitations of voluntary medical error reports and to learn about common errors in warfarin use.
          Voluntary reports of 8,837 inpatient errors and 820 outpatient errors in warfarin use submitted by 445 hospitals and 192 outpatient facilities participating in MEDMARX, a voluntary medication error reporting system, from 2002 to 2004, were gathered. Overall, errors occurred most often during transcription/documentation (35%) and administration (30%) in hospitals, and during prescribing (31%) and dispensing (39%) in outpatient settings. Dosing errors were the most common type. In hospitals, more than 50% of reported errors were initiated by nurses, and 50% were intercepted by nurses, whereas in outpatient settings, about 50% of reported errors occurred in pharmacies and 50% were intercepted by pharmacists. About 17% of inpatient and 13% of outpatient warfarin errors resulted in changes in patient care, and 42% of inpatient and 62% of outpatient errors resulted in procedural changes. Cascade analysis and textual descriptions further located specific, correctible safety lapses.
          Voluntary medical error reporting systems can, to some extent, provide meaningful and actionable information to guide patient safety improvement, but their usefulness is limited because of a lack of details, incomplete reporting, underreporting, and various reporting biases.
JF  - Joint Commission journal on quality and patient safety
AU  - Zhan, Chunliu
AU  - Smith, Scott R
AU  - Keyes, Margaret A
AU  - Hicks, Rodney W
AU  - Cousins, Diane D
AU  - Clancy, Carolyn M
AD  - Agency for Healthcare Research and Quality (AHRQ), Department of Health and Human Services, Rockville, Maryland, USA. czhan@ahrq.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 36
EP  - 45
VL  - 34
IS  - 1
SN  - 1553-7250, 1553-7250
KW  - Warfarin
KW  - 5Q7ZVV76EI
KW  - Index Medicus
KW  - United States
KW  - Hospitals -- standards
KW  - Humans
KW  - Quality Assurance, Health Care -- methods
KW  - Program Evaluation
KW  - Ambulatory Care Facilities -- standards
KW  - Truth Disclosure
KW  - Safety Management
KW  - Male
KW  - Female
KW  - Medication Errors -- classification
KW  - Warfarin -- adverse effects
KW  - Risk Management
KW  - Warfarin -- administration & dosage
KW  - Medication Errors -- statistics & numerical data
KW  - Voluntary Programs
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70300757?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Joint+Commission+journal+on+quality+and+patient+safety&rft.atitle=How+useful+are+voluntary+medication+error+reports%3F+The+case+of+warfarin-related+medication+errors.&rft.au=Zhan%2C+Chunliu%3BSmith%2C+Scott+R%3BKeyes%2C+Margaret+A%3BHicks%2C+Rodney+W%3BCousins%2C+Diane+D%3BClancy%2C+Carolyn+M&rft.aulast=Zhan&rft.aufirst=Chunliu&rft.date=2008-01-01&rft.volume=34&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Joint+Commission+journal+on+quality+and+patient+safety&rft.issn=15537250&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-25
N1  - Date created - 2008-02-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The potential utility of HPV genotyping in screening and clinical management.
AN  - 70285584; 18267061
AB  - Detection of specific human papillomavirus (HPV) genotypes, or HPV genotyping, may be useful for differentiating between those women who are carcinogenic HPV-positive at lower and higher risk for cervical precancer and cancer. Considerable evidence already exists that the absolute risk for cervical precancer and cancer varies considerably among specific HPV genotypes, and that detection of HPV-16 and -18 may have clinical usefulness, especially among women who tested positive for carcinogenic HPV and have negative cytology. Detection of persistent carcinogenic HPV is strongly associated with cervical precancer and cancer and strongly predicts its development, and might be used to monitor the outcomes of HPV infections. However, several practical considerations must be addressed before HPV genotyping can be used in screening and clinical management.
JF  - Journal of the National Comprehensive Cancer Network : JNCCN
AU  - Castle, Philip E
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 5004, EPS MSC 7234, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 83
EP  - 95
VL  - 6
IS  - 1
SN  - 1540-1405, 1540-1405
KW  - DNA, Viral
KW  - 0
KW  - Index Medicus
KW  - Genotype
KW  - Mass Screening
KW  - DNA, Viral -- analysis
KW  - Humans
KW  - Decision Trees
KW  - Female
KW  - Uterine Cervical Neoplasms -- therapy
KW  - Cervical Intraepithelial Neoplasia -- pathology
KW  - Papillomavirus Infections -- diagnosis
KW  - Papillomavirus Infections -- virology
KW  - Uterine Cervical Neoplasms -- diagnosis
KW  - Papillomavirus Infections -- pathology
KW  - Cervical Intraepithelial Neoplasia -- therapy
KW  - Papillomaviridae -- classification
KW  - Papillomaviridae -- isolation & purification
KW  - Papillomavirus Infections -- therapy
KW  - Cervical Intraepithelial Neoplasia -- virology
KW  - Cervical Intraepithelial Neoplasia -- diagnosis
KW  - Uterine Cervical Neoplasms -- pathology
KW  - Uterine Cervical Neoplasms -- virology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70285584?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Comprehensive+Cancer+Network+%3A+JNCCN&rft.atitle=The+potential+utility+of+HPV+genotyping+in+screening+and+clinical+management.&rft.au=Castle%2C+Philip+E&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-01-01&rft.volume=6&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Comprehensive+Cancer+Network+%3A+JNCCN&rft.issn=15401405&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-08
N1  - Date created - 2008-02-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Computer-controlled ozone inhalation exposure system.
AN  - 70254802; 18236221
AB  - Accurate systems designed to expose laboratory animals to carefully controlled concentrations of gases and aerosols are an important tool in inhalation toxicology studies. These systems are necessary for determining the dose-response relationship of toxicants under a variety of exposure conditions. The objective of this project was to develop a system, employing feedback control, to expose small laboratory animals to precise concentrations of ozone. This system needed the capability of maintaining exposures at selected levels between 0.2 to 3.0 ppm over specified periods ranging between 1 and 8 h in order to evaluate health risks associated with ozone. The overall goals of this study were (1) to develop a system capable of automatically controlling the ozone exposure levels so the steady-state error remained less than 1% and (2) to optimize the system's response time. By employing a tuned control algorithm, gas monitors, data acquisition, and a custom computer software program, these two goals were realized.
JF  - Inhalation toxicology
AU  - McKinney, Walter
AU  - Frazer, Dave
AD  - Centers for Disease Control/National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. wdm9@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 43
EP  - 48
VL  - 20
IS  - 1
KW  - Ozone
KW  - 66H7ZZK23N
KW  - Index Medicus
KW  - Software
KW  - Animals
KW  - Computer Systems
KW  - Atmosphere Exposure Chambers
KW  - Ozone -- administration & dosage
KW  - Ozone -- adverse effects
KW  - Inhalation Exposure -- adverse effects
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70254802?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Computer-controlled+ozone+inhalation+exposure+system.&rft.au=McKinney%2C+Walter%3BFrazer%2C+Dave&rft.aulast=McKinney&rft.aufirst=Walter&rft.date=2008-01-01&rft.volume=20&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958370701758544
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-08
N1  - Date created - 2008-01-31
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/08958370701758544
ER  - 



TY  - JOUR
T1  - Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.
AN  - 70247730; 17984110
AB  - Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER genes-x-ray repair cross-complementing group 1 (XRCC1) (R194W, rs1799782; R280H, rs25489 and R399Q, rs25487), apurinic/apyrimidinic endonuclease (APEX1) (D148E, rs3136820) and 8-oxoguanine DNA glycosylase (OGG1) (S326C, rs1052133), in a population-based study of 411 biliary tract cancer cases (237 gallbladder, 127 bile duct and 47 ampulla of Vater), 891 biliary (gallbladder or bile duct) stone cases and 786 population controls conducted in Shanghai, China. Compared with subjects carrying the XRCC1 194RR genotype, those with the WW genotype had a 1.9-fold risk of bile duct cancer [odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.5, P(trend) = 0.03], and compared with subjects carrying the XRCC1 280RR genotype, those with the XRCC1 280H allele had a 50% reduced risk of bile duct cancer (OR = 0.5, 95% CI = 0.3-0.9, P(trend) = 0.05). The effect of the R280H polymorphism persisted (P(trend) = 0.03), when all three XRCC1 polymorphisms were jointly considered in the model, a finding supported by the haplotype results (covariate-adjusted global permutation P = 0.03). We also found an inverse association between the APEX1 148E allele and gallbladder stones (P(trend) = 0.03), but no association for the OGG1 polymorphism. This study suggests that genetic variants in XRCC1 and APEX1 may alter susceptibility to biliary tract cancer and stones. Further studies are required to confirm the reported associations.
JF  - Carcinogenesis
AU  - Huang, Wen-Yi
AU  - Gao, Yu-Tang
AU  - Rashid, Asif
AU  - Sakoda, Lori C
AU  - Deng, Jie
AU  - Shen, Ming-Chang
AU  - Wang, Bin-Sheng
AU  - Han, Tian-Quan
AU  - Zhang, Bai-He
AU  - Chen, Bingshu E
AU  - Rosenberg, Philip S
AU  - Chanock, Stephen J
AU  - Hsing, Ann W
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 100
EP  - 105
VL  - 29
IS  - 1
KW  - Index Medicus
KW  - Genotype
KW  - Humans
KW  - China -- epidemiology
KW  - Case-Control Studies
KW  - DNA Repair -- genetics
KW  - Gallstones -- epidemiology
KW  - Biliary Tract Neoplasms -- epidemiology
KW  - Polymorphism, Genetic
KW  - Biliary Tract Neoplasms -- genetics
KW  - Genetic Predisposition to Disease
KW  - Gallstones -- genetics
KW  - Population Surveillance
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Selected+base+excision+repair+gene+polymorphisms+and+susceptibility+to+biliary+tract+cancer+and+biliary+stones%3A+a+population-based+case-control+study+in+China.&rft.au=Huang%2C+Wen-Yi%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BSakoda%2C+Lori+C%3BDeng%2C+Jie%3BShen%2C+Ming-Chang%3BWang%2C+Bin-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip+S%3BChanock%2C+Stephen+J%3BHsing%2C+Ann+W&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2008-01-01&rft.volume=29&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-31
N1  - Date created - 2008-02-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Application of oligonucleotide microarray technology to toxic occupational exposures.
AN  - 70242100; 18214805
AB  - Microarray technology has advanced toward analysis of toxic occupational exposures in biological systems. Microarray analysis is an ideal way to search for biomarkers of exposure, even if no specific gene or pathway has been identified. Analysis may now be performed on thousands of genes simultaneously, as opposed to small numbers of genes as in the past. This ability has been put to use to analyze gene expression profiles of a variety of occupational toxins in animal models to classify toxins into specific categories based on response. Analysis of normal human cell strains allows an extension of this analysis to investigate the role of interindividual variation in response to various toxins. This methodology was used to analyze four occupationally related toxins in our lab: oxythioquinox (OTQ), a quinoxaline pesticide; malathion, an organophosphate pesticide; di-n-butyl phthalate (DBP), a chemical commonly found in personal care and cosmetic items; and benzo[a]pyrene (BaP), an environmental and occupational carcinogen. The results for each exposure highlighted signaling pathways involved in response to these occupational exposures. Both pesticides showed increase in metabolic enzymes, while DBP showed alterations in genes related to fertility. BaP exposure showed alterations in two cytochrome P450s related to carcinogenicity. When used with occupational exposure information, these data may be used to augment risk assessment to make the workplace safer for a greater proportion of the workforce, including individuals susceptible to disease related to exposures.
JF  - Journal of toxicology and environmental health. Part A
AU  - Gwinn, Maureen R
AU  - Weston, Ainsley
AD  - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA.
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 315
EP  - 324
VL  - 71
IS  - 5
SN  - 1528-7394, 1528-7394
KW  - Carcinogens, Environmental
KW  - 0
KW  - Pesticides
KW  - Plasticizers
KW  - Quinoxalines
KW  - Dibutyl Phthalate
KW  - 2286E5R2KE
KW  - quinomethionate
KW  - 2439-01-2
KW  - Benzo(a)pyrene
KW  - 3417WMA06D
KW  - Cytochrome P-450 Enzyme System
KW  - 9035-51-2
KW  - Malathion
KW  - U5N7SU872W
KW  - Index Medicus
KW  - Benzo(a)pyrene -- pharmacology
KW  - Cytochrome P-450 Enzyme System -- genetics
KW  - Humans
KW  - Pesticides -- pharmacology
KW  - Risk Assessment
KW  - Environmental Monitoring
KW  - Malathion -- pharmacology
KW  - Genes, p53
KW  - Signal Transduction -- genetics
KW  - Dibutyl Phthalate -- pharmacology
KW  - Plasticizers -- pharmacology
KW  - Quinoxalines -- pharmacology
KW  - Cell Line
KW  - Mammary Glands, Human -- drug effects
KW  - Gene Expression Profiling
KW  - Oligonucleotide Array Sequence Analysis
KW  - Occupational Exposure -- adverse effects
KW  - Carcinogens, Environmental -- pharmacology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Application+of+oligonucleotide+microarray+technology+to+toxic+occupational+exposures.&rft.au=Gwinn%2C+Maureen+R%3BWeston%2C+Ainsley&rft.aulast=Gwinn&rft.aufirst=Maureen&rft.date=2008-01-01&rft.volume=71&rft.issue=5&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390701738509
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-06
N1  - Date created - 2008-01-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/15287390701738509
ER  - 



TY  - JOUR
T1  - Determination of caffeine and sympathomimetic alkaloids in weight loss supplements by high-performance liquid chromatography.
AN  - 70240570; 18218190
AB  - Reversed-phase high-performance liquid chromatography utilizing photodiode array detection is used for the simultaneous determination of caffeine and nine alkaloids from Citrus aurantium (CA) and ephedra (EA) contained in dietary weight loss products. Since the Food and Drug Administration (FDA) ban of EA, manufacturers have substituted CA in their weight loss formulations, usually combined with high levels of caffeine. The alkaloids contained in CA have some physiological effects similar to those of the EA alkaloids and are, therefore, cause for concern. Caffeine has been shown to potentiate the toxicity of the EA alkaloids. Recently, a federal judge overturned the absolute ban and allowed marketing of low levels (<10 mg/day) of total EA alkaloids. To support an absolute ban, the FDA is now compelled to perform dose-dependent toxicology studies to determine the toxic dose(s) of EA. The toxicity of the CA compounds is largely unknown, especially in combination with caffeine. The described method enables quantitation over a wide range of product formulations. Recoveries range from 91% to 100% from a variety of fortified plant matrices.
JF  - Journal of chromatographic science
AU  - Evans, Ronald L
AU  - Siitonen, Paul H
AD  - National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Division of Biochemical Toxicology, Jefferson, AR 72079, USA. ronald.evans@fda.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 61
EP  - 67
VL  - 46
IS  - 1
SN  - 0021-9665, 0021-9665
KW  - Alkaloids
KW  - 0
KW  - Caffeine
KW  - 3G6A5W338E
KW  - Index Medicus
KW  - Reproducibility of Results
KW  - Chromatography, High Pressure Liquid -- methods
KW  - Caffeine -- analysis
KW  - Alkaloids -- analysis
KW  - Dietary Supplements -- analysis
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatographic+science&rft.atitle=Determination+of+caffeine+and+sympathomimetic+alkaloids+in+weight+loss+supplements+by+high-performance+liquid+chromatography.&rft.au=Evans%2C+Ronald+L%3BSiitonen%2C+Paul+H&rft.aulast=Evans&rft.aufirst=Ronald&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatographic+science&rft.issn=00219665&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-05-05
N1  - Date created - 2008-01-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents.
AN  - 70239595; 17879298
AB  - Hepatocellular carcinoma, which is one of the most prevalent life-threatening human cancers, is showing an increased incidence worldwide. Recent evidence indicates that the development of hepatocellular carcinoma is associated with not only genetic alterations, but also with profound epigenetic changes. This review summarizes the current knowledge about epigenetic alterations during rodent hepatocarcinogenesis, considers the similarities and differences in epigenetic effects of genotoxic and non-genotoxic rodent liver carcinogens, and discusses the possible role of these effects in the causality of liver tumor development.
JF  - Environmental and molecular mutagenesis
AU  - Pogribny, Igor P
AU  - Rusyn, Ivan
AU  - Beland, Frederick A
AD  - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. igor.pogribny@fda.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 9
EP  - 15
VL  - 49
IS  - 1
SN  - 0893-6692, 0893-6692
KW  - Index Medicus
KW  - Animals
KW  - DNA Damage
KW  - Humans
KW  - Disease Models, Animal
KW  - Rodentia
KW  - Carcinoma, Hepatocellular -- genetics
KW  - Liver Neoplasms -- physiopathology
KW  - Carcinoma, Hepatocellular -- physiopathology
KW  - Epigenesis, Genetic
KW  - Liver Neoplasms -- genetics
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70239595?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Epigenetic+aspects+of+genotoxic+and+non-genotoxic+hepatocarcinogenesis%3A+studies+in+rodents.&rft.au=Pogribny%2C+Igor+P%3BRusyn%2C+Ivan%3BBeland%2C+Frederick+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2008-01-01&rft.volume=49&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-28
N1  - Date created - 2008-01-21
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Analysis of food-allergic and anaphylactic events in the National Electronic Injury Surveillance System.
AN  - 70219372; 18206508
AB  - The National Electronic Injury Surveillance System (NEISS) captures a nationally representative probability sample from hospital emergency departments (EDs) in the United States.
          Emergency department data from NEISS were analyzed to assess the magnitude and severity of adverse events attributable to food allergies. Emergency department events describing food-related allergic symptomatology were identified from 34 participating EDs from August 1 to September 30, 2003.
          Extrapolation of NEISS event data predicts a total of 20,821 hospital ED visits, 2333 visits for anaphylaxis, and 520 hospitalizations caused by food allergy in the United States during the 2-month study period. The median age was 26 years; 24% of visits involved children  or =6 years old, whereas children < or =5 years old experienced more events from eggs, fruit, peanuts, and tree nuts. There were no reported deaths. Review of medical records found that only 19% of patients received epinephrine, and, using criteria established by a 2005 anaphylaxis symposium, 57% of likely anaphylactic events did not have an ED diagnosis of anaphylaxis.
          Analysis of NEISS data may be a useful tool for assessing the magnitude and severity of food-allergic events. A criteria-based review of medical records suggests underdiagnosis of anaphylactic events in EDs.
JF  - The Journal of allergy and clinical immunology
AU  - Ross, Marianne Phelan
AU  - Ferguson, Martine
AU  - Street, Debra
AU  - Klontz, Karl
AU  - Schroeder, Tom
AU  - Luccioli, Stefano
AD  - Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA. Marianne.Ross@fda.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 166
EP  - 171
VL  - 121
IS  - 1
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Anaphylaxis -- epidemiology
KW  - Nuts -- adverse effects
KW  - Food Hypersensitivity -- etiology
KW  - Food Hypersensitivity -- epidemiology
KW  - Humans
KW  - Child
KW  - Fruit -- adverse effects
KW  - Child, Preschool
KW  - Infant
KW  - Shellfish -- adverse effects
KW  - Eggs -- adverse effects
KW  - Peanut Hypersensitivity
KW  - Adult
KW  - Anaphylaxis -- etiology
KW  - Emergency Service, Hospital -- statistics & numerical data
KW  - Adolescent
KW  - Hospitalization -- statistics & numerical data
KW  - United States -- epidemiology
KW  - Adverse Drug Reaction Reporting Systems
KW  - Population Surveillance -- methods
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70219372?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Analysis+of+food-allergic+and+anaphylactic+events+in+the+National+Electronic+Injury+Surveillance+System.&rft.au=Ross%2C+Marianne+Phelan%3BFerguson%2C+Martine%3BStreet%2C+Debra%3BKlontz%2C+Karl%3BSchroeder%2C+Tom%3BLuccioli%2C+Stefano&rft.aulast=Ross&rft.aufirst=Marianne&rft.date=2008-01-01&rft.volume=121&rft.issue=1&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/10.1016%2Fj.jaci.2007.10.012
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-25
N1  - Date created - 2008-01-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1016/j.jaci.2007.10.012
ER  - 



TY  - JOUR
T1  - Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies.
AN  - 70211274; 18197312
AB  - Conflicting views have been expressed frequently on assessments of human cancer risk of environmental agents based on animal carcinogenicity data; this is primarily because of uncertainties associated with extrapolations of toxicologic findings from studies in experimental animals to human circumstances. Underlying these uncertainties are issues related to how experiments are designed, how rigorously hypotheses are tested, and to what extent assertions extend beyond actual findings. National and international health agencies regard carcinogenicity findings in well-conducted experimental animal studies as evidence of potential carcinogenic risk to humans. Controversies arise when both positive and negative carcinogenicity data exist for a specific agent or when incomplete mechanistic data suggest a possible species difference in response. Issues of experimental design and evaluation that might contribute to disparate results are addressed in this article. To serve as reliable sources of data for the evaluation of the carcinogenic potential of environmental agents, experimental studies must include a) animal models that are sensitive to the end points under investigation; b) detailed characterization of the agent and the administered doses; c) challenging doses and durations of exposure (at least 2 years for rats and mice); d) sufficient numbers of animals per dose group to be capable of detecting a true effect; e) multiple dose groups to allow characterization of dose-response relationships, f) complete and peer-reviewed histopathologic evaluations; and g) pairwise comparisons and analyses of trends based on survival-adjusted tumor incidence. Pharmacokinetic models and mechanistic hypotheses may provide insights into the biological behavior of the agent; however, they must be adequately tested before being used to evaluate human cancer risk.
JF  - Environmental health perspectives
AU  - Melnick, Ronald L
AU  - Thayer, Kristina A
AU  - Bucher, John R
AD  - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. melnickr@niehs.nih.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 130
EP  - 135
VL  - 116
IS  - 1
SN  - 0091-6765, 0091-6765
KW  - Carcinogens
KW  - 0
KW  - Index Medicus
KW  - tumor pathology
KW  - maximally tolerated dose
KW  - statistical power
KW  - mode of action
KW  - rodent cancer bioassay
KW  - dose selection
KW  - Rats
KW  - Animals
KW  - Public Health
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Carcinogenicity Tests -- methods
KW  - Mice
KW  - Research Design
KW  - Risk Assessment
KW  - Carcinogens -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-25
N1  - Date created - 2008-01-16
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Natl Toxicol Program Tech Rep Ser. 2006 Feb;(533):1-264 [16741556]
J Cancer Res Clin Oncol. 1999;125(3-4):219-25 [10235477]
Carcinogenesis. 2000 Apr;21(4):823-6 [10753222]
J Cancer Res Clin Oncol. 2000 Apr;126(4):246 [10782899]
IARC Monogr Eval Carcinog Risks Hum. 1999;73:339-83 [10804962]
Environ Health Perspect. 2000 May;108 Suppl 2:265-73 [10807557]
Environ Health Perspect. 2000 May;108 Suppl 2:283-305 [10807559]
Toxicol Sci. 2000 Jun;55(2):433-43 [10828276]
IARC Monogr Eval Carcinog Risks Hum. 2000;77:41-148 [11100399]
FASEB J. 2001 Jan;15(1):195-203 [11149907]
Food Chem Toxicol. 2001 Jul;39(7):739-44 [11397520]
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Int J Occup Environ Health. 2002 Apr-Jun;8(2):144-52 [12019681]
Br J Cancer. 2003 Jan 13;88(1):84-9 [12556964]
Ann N Y Acad Sci. 2002 Dec;982:177-89 [12562636]
Toxicol Sci. 2003 Sep;75(1):7-15 [12805639]
Crit Rev Toxicol. 2003;33(6):655-780 [14727734]
Environ Health Perspect. 2004 Sep;112(13):1269-74 [15345338]
Arch Toxicol. 1977 Jul 19;37(3):233-6 [332116]
Natl Cancer Inst Monogr. 1979 May;(51):25-35 [481577]
Food Chem Toxicol. 1983 Dec;21(6):825-32 [6363233]
Arch Toxicol. 1984 Oct;55(4):213-8 [6517696]
Environ Health Perspect. 1984 Dec;58:385-92 [6525993]
Toxicol Pathol. 1983;11(1):77-82 [6681400]
J Natl Cancer Inst. 1986 Feb;76(2):283-9 [3456066]
Am Ind Hyg Assoc J. 1987 May;48(5):407-13 [3591659]
Fundam Appl Toxicol. 1988 Apr;10(3):385-94 [3286346]
Cancer Res. 1988 Dec 1;48(23):6739-44 [3180084]
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N Engl J Med. 2005 Jul 14;353(2):116-8 [16014880]
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Natl Toxicol Program Tech Rep Ser. 2005 Dec;(517):1-255 [16362061]
Cancer Res. 1990 Oct 15;50(20):6592-9 [2208121]
Rev Environ Contam Toxicol. 1992;124:111-44 [1732994]
Chem Res Toxicol. 1991 Mar-Apr;4(2):168-79 [1664256]
Biochemistry. 1993 Jun 1;32(21):5598-604 [7684926]
IARC Monogr Eval Carcinog Risks Hum. 1994;60:73-159 [7869582]
Toxicol Pathol. 1994 Sep-Oct;22(5):457-72 [7899775]
Fundam Appl Toxicol. 1995 Aug;27(1):95-105 [7589934]
Toxicol Lett. 1995 Sep;79(1-3):107-14 [7570646]
Biochim Biophys Acta. 1996 Jul 26;1302(2):93-109 [8695669]
Fundam Appl Toxicol. 1996 May;31(1):1-8 [8998945]
Ann N Y Acad Sci. 1996 Dec 27;804:252-65 [8993548]
J Appl Toxicol. 1997 May;17 Suppl 1:S45-55 [9179727]
IARC Monogr Eval Carcinog Risks Hum. 1997;69:33-343 [9336729]
Med Hypotheses. 1998 Jun;50(6):525-9 [9710329]
J Occup Health. 2007 May;49(3):172-82 [17575397]
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1289/ehp.9989
ER  - 



TY  - JOUR
T1  - Ultrafine and respirable particles in an automotive grey iron foundry.
AN  - 70206585; 18056626
AB  - Ultrafine particle number and respirable particle mass concentrations were measured throughout an automotive grey iron foundry during winter, spring and summer using a particle concentration mapping procedure. Substantial temporal and spatial variability was observed in all seasons and attributed, in part, to the batch nature of operations, process emission variability and frequent work interruptions. The need for fine mapping grids was demonstrated, where elevations in particle concentrations were highly localized. Ultrafine particle concentrations were generally greatest during winter when incoming make-up air was heated with direct fire, natural gas burners. Make-up air drawn from roof level had elevated respirable mass and ultrafine number concentrations above ambient outdoor levels, suggesting inadvertent recirculation of foundry process emissions. Elevated respirable mass concentrations were highly localized on occasions (e.g. abrasive blasting and grinding), depended on the area within the facility where measurements were obtained, but were largely unaffected by season. Particle sources were further characterized by measuring their respective number and mass concentrations by particle size. Sources that contributed to ultrafine particles included process-specific sources (e.g. melting and pouring operations), and non-process sources (e.g. direct fire natural gas heating units, a liquid propane-fuelled sweeper and cigarette smoking) were additionally identified.
JF  - The Annals of occupational hygiene
AU  - Evans, Douglas E
AU  - Heitbrink, William A
AU  - Slavin, Thomas J
AU  - Peters, Thomas M
AD  - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R3, Cincinnati, OH 45226, USA.
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 9
EP  - 21
VL  - 52
IS  - 1
SN  - 0003-4878, 0003-4878
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Iron
KW  - E1UOL152H7
KW  - Index Medicus
KW  - Inhalation Exposure -- analysis
KW  - Particle Size
KW  - Humans
KW  - Seasons
KW  - Occupational Exposure -- analysis
KW  - Environmental Monitoring -- methods
KW  - Air Pollutants, Occupational -- analysis
KW  - Metallurgy
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-06-19
N1  - Date created - 2008-01-15
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - A comparison of the CATHIA-T sampler, the GK2.69 cyclone and the standard cowled sampler for thoracic fiber concentrations at a Taconite (iron ore)-processing mill.
AN  - 70205767; 18195326
AB  - Several recommendations have been made to the effect that the most appropriate health-based size-selective criterion for fibers is the thoracic convention of the International Organization for Standardization (ISO). The performance of two thoracic samplers, the CATHIA-T (37-mm filter) and the GK2.69 cyclone (37-mm filter), was investigated against the standard 25-mm cowled sampler (current NIOSH 7400 standard method) to determine the effect of thoracic sampling on field results. A total of 270 samples: 80 field and 10 field blank samples for each sampler type, were taken from seven stations in the processing mill of an iron ore mine whose ore contains amphibole minerals. Slides were prepared using the dimethyl formamide/Euparal technique and relocatable cover slips. Two counters examined the slides according to NIOSH 7400 counting A rules with phase contrast microscopes. Prior to counting the sample slides, four reference slides were randomly selected and counted three times on different days to compare the coefficient of variation (CV) between and within counters. Also, seven reference slides were chosen to explore variability between the two microscopes. The average CV between counters (0.148) showed slightly higher than the average CVs within counters (0.072 for Counter 1 and 0.119 for Counter 2). The average CV between the two microscopes was 0.147. Compared to the standard cowled sampler, the overall fiber concentration was lower for the CATHIA-T sampler (CATHIA-T/Cowled = 0.63) and higher for the GK2.69 cyclone (GK2.69/Cowled = 1.66). The result for the CATHIA-T sampler is as expected from laboratory trials, but the result for the GK2.69 cyclone is not as expected. In conclusion, the CATHIA-T sampler has a potential advantage as a high-flow static sampler for screening coarse particles. However, these findings resulted from one field sampling site that contains amphibole minerals, not all of which are asbestiform. Thus, additional field samples from other environments might be helpful to confirm the performance of these samplers.
JF  - The Annals of occupational hygiene
AU  - Lee, Eun Gyung
AU  - Harper, Martin
AU  - Nelson, John
AU  - Hintz, Patrick J
AU  - Andrew, Michael E
AD  - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS-3030, Morgantown, WV 26505, USA. elee2@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 55
EP  - 62
VL  - 52
IS  - 1
SN  - 0003-4878, 0003-4878
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Mineral Fibers
KW  - Iron
KW  - E1UOL152H7
KW  - Index Medicus
KW  - Reproducibility of Results
KW  - Inhalation Exposure -- analysis
KW  - Particle Size
KW  - Humans
KW  - Mineral Fibers -- analysis
KW  - Air Pollutants, Occupational -- analysis
KW  - Metallurgy
KW  - Environmental Monitoring -- methods
KW  - Environmental Monitoring -- instrumentation
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-06-19
N1  - Date created - 2008-01-15
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1093/annhyg/mem062
ER  - 



TY  - JOUR
T1  - Identification of mold and dampness-associated respiratory morbidity in 2 schools: comparison of questionnaire survey responses to national data.
AN  - 70188533; 18177298
AB  - Dampness and mold problems are frequently encountered in schools. Approximately one third of US public schools require extensive repairs or need at least 1 building replaced. This study illustrates how national data can be used to identify building-related health risks in school employees and students.
          School employees (n = 309) in 2 elementary schools (schools A and B) with dampness and mold problems completed standardized questionnaires. Responses were compared with participant responses from the 3rd National Health and Nutrition Examination Survey and were indirectly standardized for gender, age, smoking status, and (for school B) race. Uncontrolled comparisons were made to responses from a study of office workers, as well as between responses from school employees in different sections of the school buildings designated by decade of construction. Employees from both schools had excess work-related throat and lower respiratory symptoms, as well as eye, nasal, sinus, and wheezing symptoms. School B employees also had excess physician-diagnosed asthma and work-related fatigue, headache, and skin irritation. Employees in sections of the school buildings that were categorized as having greater dampness and mold contamination had more frequent upper and lower respiratory symptoms than employees working in other building sections.
          This noncostly type of analysis of indoor air quality complaints can be used to motivate and prioritize building remediation in public schools where funds for building remediation are usually limited.
JF  - The Journal of school health
AU  - Sahakian, Nancy M
AU  - White, Sandra K
AU  - Park, Ju-Hyeong
AU  - Cox-Ganser, Jean M
AU  - Kreiss, Kathleen
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505, USA. nsahakian@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 32
EP  - 37
VL  - 78
IS  - 1
SN  - 0022-4391, 0022-4391
KW  - Index Medicus
KW  - Nursing
KW  - Air Pollution, Indoor -- adverse effects
KW  - Humans
KW  - Adult
KW  - Middle Aged
KW  - Environmental Exposure -- adverse effects
KW  - Male
KW  - Female
KW  - Schools
KW  - Fungi
KW  - Respiratory Tract Diseases -- etiology
KW  - Humidity -- adverse effects
KW  - Health Surveys
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+school+health&rft.atitle=Identification+of+mold+and+dampness-associated+respiratory+morbidity+in+2+schools%3A+comparison+of+questionnaire+survey+responses+to+national+data.&rft.au=Sahakian%2C+Nancy+M%3BWhite%2C+Sandra+K%3BPark%2C+Ju-Hyeong%3BCox-Ganser%2C+Jean+M%3BKreiss%2C+Kathleen&rft.aulast=Sahakian&rft.aufirst=Nancy&rft.date=2008-01-01&rft.volume=78&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+school+health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fj.1746-1561.2007.00263.x
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-04
N1  - Date created - 2008-01-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1111/j.1746-1561.2007.00263.x
ER  - 



TY  - JOUR
T1  - NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation.
AN  - 70182404; 17986233
AB  - A novel radioligand, 6-chloro-3-((2-(S)-azetidinyl)methoxy)-5-(2-fluoropyridin-4-yl)pyridine (NIDA522131), for imaging extrathalamic nicotinic acetylcholine receptors (nAChRs) was characterized in vitro and in vivo using positron emission tomography. The K(d) and T(1/2) of dissociation of NIDA522131 binding measured at 37 degrees C in vitro were 4.9 +/- 0.4 pmol/L and 81 +/- 5 min, respectively. The patterns of radioactivity distribution in monkey brain in vivo was similar to that of 2-[(18)F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2FA), a radioligand that has been successfully used in humans, and matched the alpha(4)beta(2)* nAChRs distribution. Comparison between [(18)F]NIDA522131 and 2FA demonstrated better in vivo binding properties of the new radioligand and substantially greater radioactivity accumulation in brain. Consistent with [(18)F]NIDA522131 elevated affinity for nAChRs and its increased lipophilicity, both, the total and non-displaceable distribution volumes were substantially higher than those of 2FA. Estimated binding potential values in different brain regions, characterizing the specificity of receptor binding, were 3-4 fold higher for [(18)F]NIDA522131 than those of 2FA. Pharmacological evaluation in mice demonstrated a toxicity that was comparable to 2FA and is in agreement with a 2300 fold higher affinity at alpha(4)beta(2)* versus alpha(3)beta(4)* nAChRs. These results suggest that [(18)F]NIDA522131 is a promising positron emission tomography radioligand for studying extrathalamic nAChR in humans.
JF  - Journal of neurochemistry
AU  - Chefer, Svetlana I
AU  - Pavlova, Olga A
AU  - Zhang, Yi
AU  - Vaupel, D Bruce
AU  - Kimes, Alane S
AU  - Horti, Andrew G
AU  - Stein, Elliot
AU  - Mukhin, Alexey G
AD  - Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Department of Health and Human Services, Baltimore, Maryland, USA.
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 306
EP  - 315
VL  - 104
IS  - 2
KW  - 6-chloro-3-((2-azetidinyl)methoxy)-5-(2-fluoropyridin-5-yl)pyridine
KW  - 0
KW  - Azetidines
KW  - Fluorine Radioisotopes
KW  - Pyridines
KW  - Radiopharmaceuticals
KW  - Receptors, Nicotinic
KW  - Index Medicus
KW  - Animals
KW  - Positron-Emission Tomography -- methods
KW  - Dose-Response Relationship, Drug
KW  - Binding, Competitive -- drug effects
KW  - Mice
KW  - Autoradiography
KW  - Rats
KW  - Evaluation Studies as Topic
KW  - Behavior, Animal -- drug effects
KW  - Plasma -- drug effects
KW  - In Vitro Techniques
KW  - Macaca mulatta
KW  - Motor Activity -- drug effects
KW  - Male
KW  - Azetidines -- chemistry
KW  - Thalamus -- diagnostic imaging
KW  - Pyridines -- chemistry
KW  - Fluorine Radioisotopes -- pharmacokinetics
KW  - Radiopharmaceuticals -- pharmacology
KW  - Radiopharmaceuticals -- chemical synthesis
KW  - Receptors, Nicotinic -- drug effects
KW  - Radiopharmaceuticals -- chemistry
KW  - Azetidines -- pharmacology
KW  - Pyridines -- pharmacology
KW  - Fluorine Radioisotopes -- chemistry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-05
N1  - Date created - 2008-01-04
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Improving women's health through modernization of our bioinformatics infrastructure.
AN  - 70167949; 17987048
AB  - Our nationwide bioinformatics infrastructure used to detect important sex differences associated with medical product use is antiquated. The Food and Drug Administration (FDA) has embarked on an ambitious bioinformatics modernization effort that will improve our ability to assess the safety and effectiveness of new medical products. This, in turn, will improve our ability to detect important sex differences.
JF  - Clinical pharmacology and therapeutics
AU  - Oliva, A
AU  - Pinnow, E
AU  - Levin, R
AU  - Uhl, K
AD  - Office of Critical Path Programs, Food and Drug Administration, Rockville, Maryland, USA. armando.oliva@fda.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 192
EP  - 195
VL  - 83
IS  - 1
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Consumer Product Safety
KW  - Sex Factors
KW  - Humans
KW  - Information Dissemination
KW  - Program Development
KW  - Health Knowledge, Attitudes, Practice
KW  - Clinical Trials as Topic
KW  - Patient Selection
KW  - Male
KW  - Female
KW  - Risk Assessment
KW  - Women's Health
KW  - Drug-Related Side Effects and Adverse Reactions
KW  - United States Food and Drug Administration -- organization & administration
KW  - Computational Biology -- organization & administration
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-24
N1  - Date created - 2007-12-31
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score.
AN  - 70166527; 17855015
AB  - To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) score.
          Patients with localized prostate cancer received amifostine as a rectal suspension 30-45 minutes before daily three-dimensional conformal radiation therapy. The first 18 patients received 1 g of amifostine, and the next 12 patients received 2 g. Toxicity was assessed at baseline, during treatment, and at follow-up visits by using RTOG grading and the EPIC Quality of Life (QoL) 50-item questionnaire. The Bowel Function subset of the bowel domain (EPIC-BF), which targets symptom severity, and the Bowel Bother subset of the bowel domain (EPIC-BB), which assesses QoL, were evaluated and compared with the RTOG GI toxicity score. Median follow-up was 30 months (range, 18-36 months). Overall, EPIC-BF and EPIC-BB scores both tracked closely with the RTOG GI toxicity score. Seven weeks after the start of radiation therapy, the incidence of RTOG Grade 2 toxicity was 33% in the 1-g group (6/18 patients) compared with 0% (0/12 patients) in the 2-g group and tended toward statistical significance (p = 0.06). A significant difference between amifostine groups was observed using the EPIC-BF score at 7 weeks (p = 0.04). A difference in EPIC-BB scores between dose groups was evident at 7 weeks (p = 0.07) and was significant at 12 months (p = 0.04).
          Higher doses of amifostine produced significant improvements in acute and late bowel QoL (up to 1 year after therapy), measured using the EPIC score.
JF  - International journal of radiation oncology, biology, physics
AU  - Simone, Nicole L
AU  - Ménard, Cynthia
AU  - Soule, Benjamin P
AU  - Albert, Paul S
AU  - Guion, Peter
AU  - Smith, Sharon
AU  - Godette, Denise
AU  - Crouse, Nancy S
AU  - Sciuto, Linda C
AU  - Cooley-Zgela, Theresa
AU  - Camphausen, Kevin
AU  - Coleman, C Norman
AU  - Singh, Anurag K
AD  - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Y1  - 2008/01/01/
PY  - 2008
DA  - 2008 Jan 01
SP  - 90
EP  - 95
VL  - 70
IS  - 1
SN  - 0360-3016, 0360-3016
KW  - Radiation-Protective Agents
KW  - 0
KW  - Amifostine
KW  - M487QF2F4V
KW  - Index Medicus
KW  - Severity of Illness Index
KW  - Dose-Response Relationship, Drug
KW  - Radiation Injuries -- prevention & control
KW  - Humans
KW  - Rectum -- radiation effects
KW  - Surveys and Questionnaires
KW  - Aged
KW  - Middle Aged
KW  - Follow-Up Studies
KW  - Administration, Rectal
KW  - Male
KW  - Adenocarcinoma -- radiotherapy
KW  - Radiation-Protective Agents -- administration & dosage
KW  - Quality of Life
KW  - Proctitis -- prevention & control
KW  - Amifostine -- administration & dosage
KW  - Prostatic Neoplasms -- radiotherapy
KW  - Radiotherapy, Conformal -- adverse effects
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70166527?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Intrarectal+amifostine+during+external+beam+radiation+therapy+for+prostate+cancer+produces+significant+improvements+in+Quality+of+Life+measured+by+EPIC+score.&rft.au=Simone%2C+Nicole+L%3BM%C3%A9nard%2C+Cynthia%3BSoule%2C+Benjamin+P%3BAlbert%2C+Paul+S%3BGuion%2C+Peter%3BSmith%2C+Sharon%3BGodette%2C+Denise%3BCrouse%2C+Nancy+S%3BSciuto%2C+Linda+C%3BCooley-Zgela%2C+Theresa%3BCamphausen%2C+Kevin%3BColeman%2C+C+Norman%3BSingh%2C+Anurag+K&rft.aulast=Simone&rft.aufirst=Nicole&rft.date=2008-01-01&rft.volume=70&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-07
N1  - Date created - 2007-12-18
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Int J Radiat Oncol Biol Phys. 2005 Jun 1;62(2):486-93 [15890591]
Radiat Res. 1995 Jul;143(1):107-10 [7597137]
JAMA. 2005 Sep 14;294(10):1233-9 [16160131]
Int J Impot Res. 2006 Jan-Feb;18(1):69-76 [16094413]
Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1008-13 [16730138]
Strahlenther Onkol. 1999 Nov;175 Suppl 4:27-9 [10584137]
Radiother Oncol. 2000 Jan;54(1):11-9 [10719695]
J Clin Oncol. 2000 Jun;18(11):2226-33 [10829042]
Int J Radiat Oncol Biol Phys. 1978 Jul-Aug;4(7-8):643-7 [213406]
Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):735-42 [14967428]
Urology. 2000 Dec 20;56(6):899-905 [11113727]
Radiat Res. 1978 Oct;76(1):172-9 [216048]
Int J Radiat Oncol Biol Phys. 1983 Apr;9(4):507-13 [6303992]
Radiobiol Radiother (Berl). 1983;24(3):357-64 [6314424]
Int J Radiat Oncol Biol Phys. 2003 Jun 1;56(2):454-61 [12738320]
Int J Radiat Oncol Biol Phys. 2003 Jul 15;56(4):1154-60 [12829154]
CA Cancer J Clin. 2001 Jan-Feb;51(1):15-36 [11577478]
Int J Radiat Oncol Biol Phys. 2001 Nov 15;51(4):988-93 [11704322]
Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1097-105 [12128107]
Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1160-4 [12128116]
Semin Oncol. 2002 Dec;29(6 Suppl 19):57-60 [12577246]
Gastroenterology. 1986 Sep;91(3):644-50 [3015711]
Int J Radiat Oncol Biol Phys. 1991 Oct;21(5):1241-6 [1657841]
Int J Radiat Oncol Biol Phys. 1992;22(4):799-802 [1312078]
Cancer. 1992 Jun 1;69(11):2820-5 [1315211]
Cancer. 1994 Oct 15;74(8):2379-84 [7922989]
Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1316-21 [16029787]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Risk assessment to guide the prevention of cervical cancer.
AN  - 70164734; 18162804
AB  - Advances in screening and diagnosis make it increasingly possible to prevent cervical cancer. However, if misused or poorly understood, these new tools will only increase costs and potentially harm patients without benefit. As a framework for standardized care that maximizes patient safety and well-being, we propose that a risk model be adopted to guide clinical management now and in the future. The model would use thresholds of increasing risk for cervical precancer and treatable cancer to guide clinical decision making for screening intensity, diagnostic evaluation, or treatment. Experts would decide on these risk thresholds and stratum based on the patient risk to benefit, independent of current (e.g., cytology, carcinogenic human papillomavirus testing, and colposcopy) and future methods of measuring risk. A risk management model for cervical cancer prevention, based on appropriate clinical actions that correspond to risk stratum, can result in better allocation of resources to and increased safety for women at the greatest risk and increased well-being for women at the lowest risk.
JF  - Journal of lower genital tract disease
AU  - Castle, Philip E
AU  - Sideri, Mario
AU  - Jeronimo, Jose
AU  - Solomon, Diane
AU  - Schiffman, Mark
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 1
EP  - 7
VL  - 12
IS  - 1
SN  - 1089-2591, 1089-2591
KW  - Index Medicus
KW  - Risk Factors
KW  - Papillomaviridae -- isolation & purification
KW  - Humans
KW  - Vaginal Smears
KW  - Female
KW  - Colposcopy
KW  - Risk Assessment
KW  - Neoplasms, Squamous Cell -- prevention & control
KW  - Uterine Cervical Neoplasms -- prevention & control
KW  - Papillomavirus Infections -- diagnosis
KW  - Cervical Intraepithelial Neoplasia -- surgery
KW  - Uterine Cervical Neoplasms -- diagnosis
KW  - Algorithms
KW  - Neoplasms, Squamous Cell -- diagnosis
KW  - Cervical Intraepithelial Neoplasia -- diagnosis
KW  - Uterine Cervical Dysplasia -- diagnosis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-27
N1  - Date created - 2007-12-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Conservation of the pro-apoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasites.
AN  - 70156521; 18073240
AB  - Endonuclease G is a mitochondrial protein implicated in DNA fragmentation during apoptosis in cell types ranging from fungi to mammals. Features of programmed cell death have been reported in a number of single-celled organisms, including the human trypanosomatid parasites Leishmania and Trypanosoma. However, the protozoan cell death pathways and the effector molecules involved in such processes remain to be identified. In this report, we describe the pro-apoptotic function of endonuclease G in trypanosomatid parasites. Similar to metazoans, trypanosome endoG showed intrinsic nuclease activity, is localized in mitochondria and is released from this organelle when cell death is triggered. Overexpression of endoG strongly promoted apoptotic cell death under oxidant or differentiation-related stress in Leishmania and, conversely, loss of endoG expression conferred robust resistance to oxidant-induced cell death in T. brucei. These data demonstrate the conservation of the pro-apoptotic endonuclease activity of endoG in these evolutionarily ancient eukaryotic organisms. Furthermore, nuclear DNA degradation by endoG upon release from mitochondria might represent a caspase-independent cell death mechanism in trypanosomatid parasites as genes encoding caspase-like proteins have not been identified in their genomes.
JF  - Journal of cell science
AU  - Gannavaram, Sreenivas
AU  - Vedvyas, Chetan
AU  - Debrabant, Alain
AD  - Laboratory of Bacterial, Parasitic and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda MD 20892, USA.
Y1  - 2008/01/01/
PY  - 2008
DA  - 2008 Jan 01
SP  - 99
EP  - 109
VL  - 121
SN  - 0021-9533, 0021-9533
KW  - Oxidants
KW  - 0
KW  - Hydrogen Peroxide
KW  - BBX060AN9V
KW  - Endodeoxyribonucleases
KW  - EC 3.1.-
KW  - endonuclease G
KW  - EC 3.1.21.-
KW  - Index Medicus
KW  - Leishmania donovani -- enzymology
KW  - Animals
KW  - Trypanosoma brucei brucei -- growth & development
KW  - Leishmania donovani -- growth & development
KW  - Humans
KW  - Mitochondria -- enzymology
KW  - Macrophages -- parasitology
KW  - Amino Acid Sequence
KW  - Leishmania donovani -- genetics
KW  - Genome, Protozoan
KW  - Hydrogen Peroxide -- toxicity
KW  - In Situ Nick-End Labeling
KW  - Sequence Alignment
KW  - Trypanosoma brucei brucei -- enzymology
KW  - Oxidants -- toxicity
KW  - Molecular Sequence Data
KW  - RNA Interference
KW  - Fluorescent Antibody Technique
KW  - Trypanosomatina -- enzymology
KW  - Apoptosis -- genetics
KW  - Endodeoxyribonucleases -- chemistry
KW  - Endodeoxyribonucleases -- isolation & purification
KW  - Trypanosomatina -- pathogenicity
KW  - Endodeoxyribonucleases -- genetics
KW  - Endodeoxyribonucleases -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-05-05
N1  - Date created - 2007-12-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Concentration-QT relationships play a key role in the evaluation of proarrhythmic risk during regulatory review.
AN  - 70155875; 18094216
AB  - The criterion for assessing whether a drug prolongs QT as described in the International Conference on Harmonization topic E14 guideline does not explicitly account for individual drug concentrations. The authors' experience with reviewing QT studies indicates that understanding the relationship, if any, between individual drug concentration and QT change provides important additional information to support regulatory decision making. Therefore, regulatory reviews of "thorough QT" studies routinely include a characterization of the concentration-QT relationship. The authors provide examples to illustrate how the concentration-QT relationship has been used to plan and interpret the thorough QT study, to evaluate QT risk for drugs that have no thorough QT studies, to assess QT risk in subpopulations, to make dose adjustments, and to write informative drug labels.
JF  - Journal of clinical pharmacology
AU  - Garnett, Christine E
AU  - Beasley, Nhi
AU  - Bhattaram, V Atul
AU  - Jadhav, Pravin R
AU  - Madabushi, Rajanikanth
AU  - Stockbridge, Norman
AU  - Tornøe, Christoffer W
AU  - Wang, Yaning
AU  - Zhu, Hao
AU  - Gobburu, Jogarao V
AD  - Office of Clinical Pharmacology, Center of Drug Evaluation and Reseach, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20903-0002, USA. christine.garnett@fda.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 13
EP  - 18
VL  - 48
IS  - 1
SN  - 0091-2700, 0091-2700
KW  - Drugs, Investigational
KW  - 0
KW  - Index Medicus
KW  - Dose-Response Relationship, Drug
KW  - Risk Factors
KW  - Humans
KW  - Clinical Trials as Topic
KW  - Guidelines as Topic
KW  - Risk Assessment -- methods
KW  - Arrhythmias, Cardiac -- diagnosis
KW  - Arrhythmias, Cardiac -- chemically induced
KW  - Long QT Syndrome -- chemically induced
KW  - Long QT Syndrome -- diagnosis
KW  - Drugs, Investigational -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-18
N1  - Date created - 2007-12-20
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
J Clin Pharmacol. 2008 Jan;48(1):9-12 [18094215]
J Clin Pharmacol. 2008 Jan;48(1):6-8 [18094214]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Work-related asthma in the educational services industry: California, Massachusetts, Michigan, and New Jersey, 1993-2000.
AN  - 70152531; 18033692
AB  - To characterize work-related asthma (WRA) cases working in the educational services industry identified by state-based occupational disease surveillance systems.
          We examined 2,995 WRA cases reported from 1993 to 2000 to four states: California, Massachusetts, Michigan, and New Jersey. A total of 265 (9%) WRA cases were employed in the educational services industry; 69% of cases were classified as new-onset asthma and 31% as work-aggravated asthma. New-onset asthma cases were further classified as occupational asthma (61%) or as reactive airways dysfunction syndrome (8%). The most frequently reported occupation was teachers and teachers' aides (54%). The most frequently reported agents were indoor air pollutants (28%), unspecified mold (16%), dusts (14%), and cleaning products (7%).
          Asthma within the educational services industry is an occupational health problem. The health of school employees should also be considered when initiatives addressing asthma among schoolchildren are instituted. The identification, elimination, and/or control of respiratory hazards are important factors for the protection of staff and students alike. 2007 Wiley-Liss, Inc
JF  - American journal of industrial medicine
AU  - Mazurek, Jacek M
AU  - Filios, Margaret
AU  - Willis, Ruth
AU  - Rosenman, Kenneth D
AU  - Reilly, Mary Jo
AU  - McGreevy, Katharine
AU  - Schill, Donald P
AU  - Valiante, David
AU  - Pechter, Elise
AU  - Davis, Letitia
AU  - Flattery, Jennifer
AU  - Harrison, Robert
AD  - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. acq8@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 47
EP  - 59
VL  - 51
IS  - 1
SN  - 0271-3586, 0271-3586
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Index Medicus
KW  - Humans
KW  - Adult
KW  - Aged
KW  - Middle Aged
KW  - Child
KW  - Workplace
KW  - Adolescent
KW  - United States -- epidemiology
KW  - Schools -- statistics & numerical data
KW  - Male
KW  - Female
KW  - Prevalence
KW  - Asthma -- epidemiology
KW  - Faculty -- statistics & numerical data
KW  - Air Pollutants, Occupational -- adverse effects
KW  - Occupational Diseases -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-21
N1  - Date created - 2007-12-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay.
AN  - 70147226; 17707568
AB  - The Brazilian mushroom Agaricus blazei Murill has antimutagenic, antioxidant, immunostimulatory and antitumorigenic activities, and is increasingly consumed as a health food worldwide. We undertook the present study to evaluate the chronic toxicity and oncogenicity of A. blazei Murill in F344 rats. To establish a no-observed-adverse-effect level (NOAEL), four treatment groups of 100 rats each (50 males and 50 females) were fed a powder diet containing lyophilized A. blazei aqueous extract at 0, 6250, 12,500, and 25,000 ppm for up to 2 years. During this period, there was no remarkable change in mean body weight, body weight gain, hematologic or serum chemistry parameters, or absolute or relative organ weights in control or treatment groups. Mortality in male treatment groups (26%, 16%, and 30%), however, was significantly lower than in controls (48%). Histopathological studies showed no increased incidence of tumors in any treatment group, and total tumor incidence across all groups was comparable to historical data. In conclusion, an A. blazei Murill lyophilized powder diet even at 25,000 ppm (1176 mg/kgb x w x /day for male rats and 1518 mg/kgb.w./day for female rats) resulted in no remarkable carcinogenic effects in F344 rats over a 2-year period. Therefore, the dietary NOAEL is 25,000 ppm.
JF  - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
AU  - Lee, I P
AU  - Kang, B H
AU  - Roh, J K
AU  - Kim, J R
AD  - Laboratory of Molecular Toxicology, Toxicological Research Center, Korea Food and Drug Administration, 5 Nokbun-Dong, Unpyong-Ku, Seoul 122-704, Republic of Korea. iplee0823@aol.com
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 87
EP  - 95
VL  - 46
IS  - 1
SN  - 0278-6915, 0278-6915
KW  - Carcinogens
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Sex Characteristics
KW  - Freeze Drying
KW  - Eye Diseases -- chemically induced
KW  - Organ Size
KW  - Blood Cell Count
KW  - Rats
KW  - Eating
KW  - Rats, Inbred F344
KW  - No-Observed-Adverse-Effect Level
KW  - Neoplasms -- pathology
KW  - Body Weight -- drug effects
KW  - Neoplasms -- chemically induced
KW  - Carcinogenicity Tests
KW  - Eye Diseases -- pathology
KW  - Diet
KW  - Female
KW  - Male
KW  - Agaricales -- chemistry
KW  - Carcinogens -- chemistry
KW  - Carcinogens -- toxicity
KW  - Agaricus -- chemistry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-11
N1  - Date created - 2007-12-17
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium.
AN  - 70090625; 17934191
AB  - Sensitive biomarkers are needed to detect kidney injury at the earliest stages. The objective of this study was to determine whether the appearance of kidney injury molecule-1 (Kim-1) protein ectodomain in urine and kidney injury molecule-1/hepatitis A viral cellular receptor-1 (Kim-1/Havcr1) gene expression in kidney tissue may be more predictive of renal injury after exposure to nephrotoxicants when compared to traditionally used biomarkers. Male Sprague-Dawley rats were injected with a range of doses of gentamicin, mercury (Hg; HgCl2), or chromium (Cr; K2Cr2O7). The results showed that increases in urinary Kim-1 and kidney Kim-1/Havcr1 gene expression paralleled the degree of severity of renal histopathology and were detected at lower doses of nephrotoxicants when compared to blood urea nitrogen (BUN), serum creatinine, and urinary N-acetyl-beta-D-glucosaminidase (NAG). In a time course study, urinary Kim-1 was elevated within 24 h after exposure to gentamicin (100 mg/kg), Hg (0.25 mg/kg), or Cr (5 mg/kg) and remained elevated through 72 h. NAG responses were nephrotoxicant dependent with elevations occurring early (gentamicin), late (Cr), or no change (Hg). At 72 h, after treatment with any of the three nephrotoxicants, there was increased Kim-1 immunoreactivity and necrosis involving approximately 50% of the proximal tubules; however, only urinary Kim-1 was significantly increased, while BUN, serum creatinine, and NAG were not different from controls. In rats treated with the hepatotoxicant galactosamine (1.1 mg/kg), serum alanine aminotransferase was increased, but no increase in urinary Kim-1 was observed. Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury following exposure to nephrotoxic chemicals and drugs.
JF  - Toxicological sciences : an official journal of the Society of Toxicology
AU  - Zhou, Yuzhao
AU  - Vaidya, Vishal S
AU  - Brown, Ronald P
AU  - Zhang, Jun
AU  - Rosenzweig, Barry A
AU  - Thompson, Karol L
AU  - Miller, Terry J
AU  - Bonventre, Joseph V
AU  - Goering, Peter L
AD  - Center for Devices and Radiological Health, U.S. Food and Drug Administration, White Oak Life Sciences Laboratory, Silver Spring, MD 20993, USA.
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 159
EP  - 170
VL  - 101
IS  - 1
SN  - 1096-6080, 1096-6080
KW  - Biomarkers
KW  - 0
KW  - Cell Adhesion Molecules
KW  - Gentamicins
KW  - Havcr1protein, rat
KW  - Membrane Proteins
KW  - Protein Synthesis Inhibitors
KW  - Chromium
KW  - 0R0008Q3JB
KW  - RNA
KW  - 63231-63-0
KW  - Galactosamine
KW  - 7535-00-4
KW  - Mercury
KW  - FXS1BY2PGL
KW  - Acetylglucosamine
KW  - V956696549
KW  - Index Medicus
KW  - Gene Expression -- drug effects
KW  - Animals
KW  - Kidney Function Tests
KW  - Chemical and Drug Induced Liver Injury -- urine
KW  - Dose-Response Relationship, Drug
KW  - Reverse Transcriptase Polymerase Chain Reaction
KW  - RNA -- biosynthesis
KW  - Rats
KW  - Acetylglucosamine -- urine
KW  - Rats, Sprague-Dawley
KW  - Galactosamine -- toxicity
KW  - RNA -- isolation & purification
KW  - Immunohistochemistry
KW  - Male
KW  - Kidney Diseases -- pathology
KW  - Kidney -- pathology
KW  - Membrane Proteins -- metabolism
KW  - Kidney Diseases -- urine
KW  - Cell Adhesion Molecules -- analysis
KW  - Membrane Proteins -- analysis
KW  - Chromium -- toxicity
KW  - Kidney -- chemistry
KW  - Cell Adhesion Molecules -- urine
KW  - Gentamicins -- toxicity
KW  - Protein Synthesis Inhibitors -- toxicity
KW  - Membrane Proteins -- urine
KW  - Cell Adhesion Molecules -- metabolism
KW  - Mercury -- toxicity
KW  - Kidney Diseases -- chemically induced
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Comparison+of+kidney+injury+molecule-1+and+other+nephrotoxicity+biomarkers+in+urine+and+kidney+following+acute+exposure+to+gentamicin%2C+mercury%2C+and+chromium.&rft.au=Zhou%2C+Yuzhao%3BVaidya%2C+Vishal+S%3BBrown%2C+Ronald+P%3BZhang%2C+Jun%3BRosenzweig%2C+Barry+A%3BThompson%2C+Karol+L%3BMiller%2C+Terry+J%3BBonventre%2C+Joseph+V%3BGoering%2C+Peter+L&rft.aulast=Zhou&rft.aufirst=Yuzhao&rft.date=2008-01-01&rft.volume=101&rft.issue=1&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-20
N1  - Date created - 2007-12-06
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Acta Vitaminol Enzymol. 1984;6(2):103-7 [6496253]
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Gen Pharmacol. 1995 Nov;26(7):1477-87 [8690234]
EMBO J. 1996 Aug 15;15(16):4282-96 [8861957]
Drug Saf. 1997 Mar;16(3):205-31 [9098657]
J Biol Chem. 1998 Feb 13;273(7):4135-42 [9461608]
Toxicol Pathol. 1998 Jan-Feb;26(1):92-103 [9502391]
J Virol. 1998 Aug;72(8):6621-8 [9658108]
J Am Soc Nephrol. 2005 Apr;16(4):1126-34 [15744000]
BMC Nephrol. 2005;6:4 [15854231]
J Am Soc Nephrol. 2005 Nov;16(11):3365-70 [16177006]
Am J Physiol Renal Physiol. 2006 Feb;290(2):F517-29 [16174863]
J Am Soc Nephrol. 2007 Mar;18(3):904-12 [17267747]
Am J Surg Pathol. 2007 Mar;31(3):371-81 [17325478]
Ren Fail. 2002 Nov;24(6):687-90 [12472192]
Free Radic Biol Med. 2003 Jun 1;34(11):1390-8 [12757849]
Toxicol Sci. 2003 Sep;75(1):208-22 [12832660]
Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63 [14600030]
Am J Med. 1968 May;44(5):664-705 [5646427]
Toxicol Appl Pharmacol. 1980 Jul;54(3):443-53 [6446781]
J Toxicol Environ Health. 1982 Jan;9(1):119-26 [6460873]
Biochem Pharmacol. 1982 Oct 1;31(19):3093-100 [6216890]
Pharmacol Rev. 2000 Mar;52(1):113-43 [10699157]
Therapie. 2000 Jan-Feb;55(1):91-6 [10860006]
J Environ Sci Health B. 2001 Sep;36(5):687-97 [11599730]
Kidney Int. 2002 Jul;62(1):237-44 [12081583]
Cleve Clin J Med. 2002 Jul;69(7):569-74 [12109642]
J Biol Chem. 2002 Oct 18;277(42):39739-48 [12138159]
Kidney Int. 1991 Apr;39(4):639-46 [1711136]
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Am J Physiol Renal Physiol. 2007 Jan;292(1):F131-9 [16835406]
Am J Physiol Renal Physiol. 2002 Dec;283(6):F1326-36 [12388382]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Assessing total fungal concentrations on commercial passenger aircraft using mixed-effects modeling.
AN  - 70089826; 18041644
AB  - The primary objective of this study was to compare airborne fungal concentrations onboard commercial passenger aircraft at various in-flight times with concentrations measured inside and outside airport terminals. A secondary objective was to investigate the use of mixed-effects modeling of repeat measures from multiple sampling intervals and locations. Sequential triplicate culturable and total spore samples were collected on wide-body commercial passenger aircraft (n = 12) in the front and rear of coach class during six sampling intervals: boarding, midclimb, early cruise, midcruise, late cruise, and deplaning. Comparison samples were collected inside and outside airport terminals at the origin and destination cities. The MIXED procedure in SAS was used to model the mean and the covariance matrix of the natural log transformed fungal concentrations. Five covariance structures were tested to determine the appropriate models for analysis. Fixed effects considered included the sampling interval and, for samples obtained onboard the aircraft, location (front/rear of coach section), occupancy rate, and carbon dioxide concentrations. Overall, both total culturable and total spore fungal concentrations were low while the aircraft were in flight. No statistical difference was observed between measurements made in the front and rear sections of the coach cabin for either culturable or total spore concentrations. Both culturable and total spore concentrations were significantly higher outside the airport terminal compared with inside the airport terminal (p-value < 0.0001) and inside the aircraft (p-value < 0.0001). On the aircraft, the majority of total fungal exposure occurred during the boarding and deplaning processes, when the aircraft utilized ancillary ventilation and passenger activity was at its peak.
JF  - Journal of occupational and environmental hygiene
AU  - McKernan, Lauralynn Taylor
AU  - Hein, Misty J
AU  - Wallingford, Kenneth M
AU  - Burge, Harriet
AU  - Herrick, Robert
AD  - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio 45226, USA. lmckernan@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 48
EP  - 58
VL  - 5
IS  - 1
SN  - 1545-9624, 1545-9624
KW  - Air Pollutants
KW  - 0
KW  - Index Medicus
KW  - Air Pollution, Indoor -- analysis
KW  - Colony Count, Microbial
KW  - Models, Statistical
KW  - Environmental Monitoring -- statistics & numerical data
KW  - Aircraft
KW  - Air Pollutants -- isolation & purification
KW  - Fungi -- isolation & purification
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-11
N1  - Date created - 2007-11-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Prevalence of asthma among youth on Hispanic-operated farms in the United States-2000.
AN  - 69877518; 19064420
AB  - The objective of this study was to estimate prevalence of asthma and asthma attacks among youth (0-19 years old) working and/or living on Hispanic-operated farms. The 2000 U.S. Minority Farm Operator Childhood Agricultural Injury Survey (M-CAIS) data were used to calculate prevalence of asthma, asthma attacks and serious asthma attacks among youth (0 to 19 years) living on Hispanic-operated farms. Age-specific asthma prevalence rates with corresponding 95% confidence intervals (CIs) were calculated for working and nonworking youth. In 2000, an estimated 17,573 youth lived on Hispanic-operated farms; 7.4% had asthma ever diagnosed, 8.1% had an asthma attack while at work in the last year, and 1.4% had a serious asthma attack. Asthma prevalence was highest among youth aged 16-19 (9.1%), males (8.6%), and those driving tractors (9.7%). Serious asthma attacks that required an emergency room visit or hospitalization in the last year were most prevalent among youth aged 0-9 years (1.8%), males (1.7%), and those riding horses (1.7%). Compared with nonworking youth, prevalence of asthma (8.9% versus 6.1%; p p > .05) was higher among working youth. Prevalence of asthma attacks in the last year while at work was also significantly higher among males than females (8.6% versus 6.0%; p p < .05). These findings contribute to the limited information on asthma among youth working on Hispanic-operated farms, and indicate the need for asthma prevention programs on farms and intervention studies targeting farming youth populations.
JF  - Journal of agromedicine
AU  - Syamlal, Girija
AU  - Mazurek, Jacek M
AD  - Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morganton, West Virginia, USA. gos2@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 155
EP  - 164
VL  - 13
IS  - 3
SN  - 1059-924X, 1059-924X
KW  - Index Medicus
KW  - Occupational Exposure
KW  - Young Adult
KW  - Occupational Health
KW  - Age Factors
KW  - Sex Factors
KW  - Humans
KW  - Infant, Newborn
KW  - Child
KW  - Child, Preschool
KW  - Infant
KW  - Off-Road Motor Vehicles
KW  - Risk Factors
KW  - Adolescent
KW  - United States -- epidemiology
KW  - Female
KW  - Male
KW  - Prevalence
KW  - Agriculture
KW  - Asthma -- epidemiology
KW  - Hispanic Americans -- statistics & numerical data
KW  - Asthma -- ethnology
KW  - Agricultural Workers' Diseases -- epidemiology
KW  - Agricultural Workers' Diseases -- ethnology
KW  - Environmental Exposure -- adverse effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Prevalence+of+asthma+among+youth+on+Hispanic-operated+farms+in+the+United+States-2000.&rft.au=Syamlal%2C+Girija%3BMazurek%2C+Jacek+M&rft.aulast=Syamlal&rft.aufirst=Girija&rft.date=2008-01-01&rft.volume=13&rft.issue=3&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F10599240802397875
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2009-01-06
N1  - Date created - 2008-12-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/10599240802397875
ER  - 



TY  - JOUR
T1  - Safety alert for fentanyl buccal tablets.
AN  - 69874373; 19062355
AB  - On September 13, 2007, the United States Food and Drug Administration posted a safety alert for fentanyl buccal tablets (Fentora). The announcement and hyperlinks to the Dear Doctor and Dear Healthcare Professional Letters that were distributed by the sponsor are presented.
JF  - Journal of pain & palliative care pharmacotherapy
AU  - U.S. Food and Drug Administration
AD  - U.S. Food and Drug Administration
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 47
VL  - 22
IS  - 1
KW  - Analgesics, Opioid
KW  - 0
KW  - Tablets
KW  - Fentanyl
KW  - UF599785JZ
KW  - Index Medicus
KW  - United States
KW  - Pain -- etiology
KW  - Pain -- drug therapy
KW  - United States Food and Drug Administration
KW  - Neoplasms -- complications
KW  - Humans
KW  - Administration, Buccal
KW  - Palliative Care
KW  - Respiratory Insufficiency -- chemically induced
KW  - Adverse Drug Reaction Reporting Systems
KW  - Fentanyl -- adverse effects
KW  - Analgesics, Opioid -- therapeutic use
KW  - Fentanyl -- therapeutic use
KW  - Analgesics, Opioid -- adverse effects
KW  - Analgesics, Opioid -- administration & dosage
KW  - Fentanyl -- administration & dosage
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2009-02-19
N1  - Date created - 2008-12-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Marijuana neurobiology and treatment.
AN  - 69849778; 19042204
AB  - Marijuana is the number one illicit drug of abuse worldwide and a major public health problem, especially in the younger population. The objective of this article is to update and review the state of the science and treatments available for marijuana dependence based on a pre-meeting workshop that was presented at ISAM 2006. At the workshop, several papers were presented addressing the neurobiology and pharmacology of marijuana and treatment approaches, both psychotherapy and medications, for marijuana withdrawal. Medicolegal and ethical issues concerning marijuana medical use were also discussed. Concise summaries of these presentations are incorporated in this article, which is meant to be an updated review of the state of the science. Major advances have been made in understanding the underpinning of marijuana dependence and the role of the CNS cannabinoid system, which is a major area for targeting medications to treat marijuana withdrawal and dependence, as well as other addictions. Behavioral therapies are efficacious for facilitating abstinence from marijuana. Nefazadone, Marinol, and buspirone are showing early positive signals for efficacy in ameliorating marijuana withdrawal symptoms. Effective psychotherapeutic approaches are available and promising medications studies need to be confirmed in outpatient trials. The next few years looking promising for translational research efforts to make treatment widely accessible to patients with marijuana dependence.
JF  - Substance abuse
AU  - Elkashef, Ahmed
AU  - Vocci, Frank
AU  - Huestis, Marilyn
AU  - Haney, Margaret
AU  - Budney, Alan
AU  - Gruber, Amanda
AU  - el-Guebaly, Nady
AD  - Clinical Medical Branch, Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. ae8a@nih.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 17
EP  - 29
VL  - 29
IS  - 3
SN  - 0889-7077, 0889-7077
KW  - Narcotic Antagonists
KW  - 0
KW  - Triazoles
KW  - nefazodone
KW  - 59H4FCV1TF
KW  - Dronabinol
KW  - 7J8897W37S
KW  - Buspirone
KW  - TK65WKS8HL
KW  - Index Medicus
KW  - Cognitive Therapy
KW  - Humans
KW  - Social Facilitation
KW  - Dronabinol -- therapeutic use
KW  - Narcotic Antagonists -- therapeutic use
KW  - Buspirone -- therapeutic use
KW  - Marijuana Abuse -- rehabilitation
KW  - Brain -- drug effects
KW  - Marijuana Abuse -- therapy
KW  - Triazoles -- therapeutic use
KW  - Cannabis -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-12-31
N1  - Date created - 2008-12-01
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
J Consult Clin Psychol. 2004 Jun;72(3):455-66 [15279529]
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Arch Gen Psychiatry. 1994 Jul;51(7):568-76 [8031230]
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Psychopharmacology (Berl). 1999 Apr;143(3):302-8 [10353434]
J Am Acad Child Adolesc Psychiatry. 2005 Jun;44(6):513-21 [15908833]
Am Heart J. 2006 Mar;151(3):754.e1-754.e5 [16504646]
J Consult Clin Psychol. 2006 Feb;74(1):42-54 [16551142]
J Consult Clin Psychol. 2006 Apr;74(2):307-16 [16649875]
Am J Addict. 2006 Sep-Oct;15(5):404 [16966201]
Addict Behav. 2007 Jun;32(6):1220-36 [16996224]
Neuropsychopharmacology. 2007 Jun;32(6):1391-403 [17091128]
Drug Alcohol Depend. 2007 Oct 8;90(2-3):210-23 [17481828]
Drug Alcohol Depend. 2005 Jul;79(1):11-22 [15943940]
Curr Psychiatry Rep. 2005 Oct;7(5):360-6 [16216154]
Addiction. 1999 Sep;94(9):1311-22 [10615717]
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Arch Gen Psychiatry. 2001 Apr;58(4):322-8 [11296091]
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J Abnorm Psychol. 2003 Aug;112(3):393-402 [12943018]
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Prog Neuropsychopharmacol Biol Psychiatry. 2004 Aug;28(5):849-63 [15363608]
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/08897070802218166
ER  - 



TY  - JOUR
T1  - Pharmacotherapy of methamphetamine addiction: an update.
AN  - 69839698; 19042205
AB  - Methamphetamine dependence is a serious public health problem worldwide for which there are no approved pharmacological treatments. Psychotherapy is still the mainstay of treatment; however, relapse rates are high. The search for effective pharmacological treatment has intensified in the last decade. This review will highlight progress in pharmacological interventions to treat methamphetamine dependence as well as explore new pharmacological targets. Published data from clinical trials for stimulant addiction were searched using PubMed and summarized, as well as highlights from a recent symposium on methamphetamine pharmacotherapy presented at the ISAM 2006 meeting, including interim analysis data from an ongoing D-amphetamine study in Australia. Early pilot data are encouraging for administering D-amphetamine and methylphenidate as treatment for heavy amphetamine users. Abilify at 15 mg/day dose increased amphetamine use in an outpatient pilot study. Sertraline, ondansetron, baclofen, tyrosine, and imipramine were ineffective in proof-of-concept studies. Development of pharmacotherapy for methamphetamine dependence is still in an early stage. Data suggesting D-amphetamine and methylphenidate as effective pharmacotherapy for methamphetamine addiction will need to be confirmed by larger trials. Preclinical data suggest that use of GVG, CB1 antagonist, and lobeline are also promising therapeutic strategies.
JF  - Substance abuse
AU  - Elkashef, Ahmed
AU  - Vocci, Frank
AU  - Hanson, Glen
AU  - White, Jason
AU  - Wickes, Wendy
AU  - Tiihonen, Jari
AD  - Clinical Medical Branch, Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. ae8a@nih.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 31
EP  - 49
VL  - 29
IS  - 3
SN  - 0889-7077, 0889-7077
KW  - Antipsychotic Agents
KW  - 0
KW  - Central Nervous System Stimulants
KW  - Narcotic Antagonists
KW  - Nicotinic Agonists
KW  - Piperazines
KW  - Quinolones
KW  - Bupropion
KW  - 01ZG3TPX31
KW  - Methylphenidate
KW  - 207ZZ9QZ49
KW  - Methamphetamine
KW  - 44RAL3456C
KW  - Aripiprazole
KW  - 82VFR53I78
KW  - Lobeline
KW  - D0P25S3P81
KW  - Dextroamphetamine
KW  - TZ47U051FI
KW  - Index Medicus
KW  - Dextroamphetamine -- therapeutic use
KW  - Nicotinic Agonists -- therapeutic use
KW  - Quinolones -- therapeutic use
KW  - Narcotic Antagonists -- therapeutic use
KW  - Bupropion -- therapeutic use
KW  - Piperazines -- therapeutic use
KW  - Humans
KW  - Antipsychotic Agents -- therapeutic use
KW  - Methylphenidate -- therapeutic use
KW  - Lobeline -- therapeutic use
KW  - Recurrence
KW  - Prevalence
KW  - Drug Therapy -- methods
KW  - Substance-Related Disorders -- rehabilitation
KW  - Substance-Related Disorders -- epidemiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839698?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Pharmacotherapy+of+methamphetamine+addiction%3A+an+update.&rft.au=Elkashef%2C+Ahmed%3BVocci%2C+Frank%3BHanson%2C+Glen%3BWhite%2C+Jason%3BWickes%2C+Wendy%3BTiihonen%2C+Jari&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2008-01-01&rft.volume=29&rft.issue=3&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/10.1080%2F08897070802218554
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-12-31
N1  - Date created - 2008-12-01
N1  - Date revised - 2017-01-13
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N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/08897070802218554
ER  - 



TY  - JOUR
T1  - Long-term consequences of drugs on the paediatric cardiovascular system.
AN  - 69819328; 19026026
AB  - Many pharmacological and toxicological actions of drugs in children cannot be fully predicted from adult clinical experience or from standard non-clinical toxicology studies. Numerous drugs have direct or indirect pharmacological effects on the heart and are prescribed for children of all ages. Toxicity or secondary effects may be immediate or delayed for years after drug exposure has ceased. Originally, the aim of this review was to compile information on the effect of specific drugs on the post-natal development of the cardiovascular system and to examine long-term follow-up of the use of cardio-active drugs in children. The limited database of published information caused the original question to evolve into an examination of the medical literature for three areas of information: (i) whether vulnerable developmental windows have been identified that reflect the substantial functional development that the cardiovascular system undergoes after birth; (ii) what is known about pharmacological perturbation of development; and (iii) what the likelihood is of drug exposure during childhood. We examined different scenarios for exposure including random, isolated exposure, conditions historically associated with adults, primary or secondary cardiac disease, psychiatric and neurological conditions, asthma, cancer and HIV. Except for random, isolated drug exposures, each category of possible exposure contained numerous drugs known to have either primary or secondary effects on the cardiovascular system or to influence factors associated with atherosclerosis. It is likely that a significant number of children will be prescribed drugs having either direct or indirect effects upon the immature cardiovascular system. A confounding factor is the simultaneous use of over-the-counter medications and herbal or nutraceutical preparations that a patient, parent or guardian does not mention to a prescribing physician. Metabolism is also important in assessing drug effects in children. Differences in body water : body fat ratio, age-related gastrointestinal absorption, distribution, excretion, renal function and drug metabolizing capabilities make it possible for children to have a different metabolite profile for a drug compared with adults. There is little examination of drug effects on the interdependent processes of cardiac maturation and less examination of metabolite effects. It is difficult to identify delayed toxicities in children as these adverse events may take years to manifest with many patients lost to follow-up. Clearly this is an area of study where intermediate endpoints and surrogate markers would be of great benefit. Pharmacogenomics may be useful in providing markers of increased risk or susceptibility. A perspective must be kept in balancing the possibility of a problem with the very real benefits that many children experience from the use of these pharmaceuticals.
JF  - Drug safety
AU  - Hausner, Elizabeth
AU  - Fiszman, Monica L
AU  - Hanig, Joseph
AU  - Harlow, Patricia
AU  - Zornberg, Gwen
AU  - Sobel, Solomon
AD  - Food and Drug Administration, Silver Spring, Maryland, USA.
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 1083
EP  - 1096
VL  - 31
IS  - 12
SN  - 0114-5916, 0114-5916
KW  - Anti-Asthmatic Agents
KW  - 0
KW  - Anti-HIV Agents
KW  - Anticonvulsants
KW  - Antineoplastic Agents
KW  - Glucocorticoids
KW  - Nonprescription Drugs
KW  - Prescription Drugs
KW  - Psychotropic Drugs
KW  - Index Medicus
KW  - Age Factors
KW  - Biomedical Research -- organization & administration
KW  - Humans
KW  - Anti-HIV Agents -- adverse effects
KW  - Anticonvulsants -- adverse effects
KW  - Complementary Therapies -- adverse effects
KW  - Child
KW  - Glucocorticoids -- adverse effects
KW  - Psychotropic Drugs -- adverse effects
KW  - Antineoplastic Agents -- adverse effects
KW  - Nonprescription Drugs -- adverse effects
KW  - Polypharmacy
KW  - Clinical Trials as Topic -- legislation & jurisprudence
KW  - Prescription Drugs -- adverse effects
KW  - Pediatrics
KW  - Child Development -- drug effects
KW  - Cardiovascular System -- drug effects
KW  - Prescription Drugs -- pharmacokinetics
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69819328?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Long-term+consequences+of+drugs+on+the+paediatric+cardiovascular+system.&rft.au=Hausner%2C+Elizabeth%3BFiszman%2C+Monica+L%3BHanig%2C+Joseph%3BHarlow%2C+Patricia%3BZornberg%2C+Gwen%3BSobel%2C+Solomon&rft.aulast=Hausner&rft.aufirst=Elizabeth&rft.date=2008-01-01&rft.volume=31&rft.issue=12&rft.spage=1083&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/10.2165%2F0002018-200831120-00005
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2009-03-05
N1  - Date created - 2008-11-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.2165/0002018-200831120-00005
ER  - 



TY  - JOUR
T1  - Ergonomics interventions at Badger Mining Corporation.
AN  - 69720219; 18954545
AB  - In 2005, the National Institute for Occupational Safety and Health (NIOSH) and Badger Mining Corporation entered a partnership to implement ergonomics interventions, including a systematic process, to address exposure to risk factors that may result in musculoskeletal disorders or other types of injuries/illnesses. As a result of this partnership, an ergonomics process was integrated with the existing safety and health programme to promote an on-going application of ergonomics principles, and over 40 task-specific interventions were implemented during the first year of the process. This paper presents details of the process integration, and several examples of task-specific interventions that reduced exposure to risk factors.
JF  - International journal of occupational safety and ergonomics : JOSE
AU  - Torma-Krajewski, Janet
AD  - National Institute for Occupational Safety and Health (NIOSH), Pittsburgh, PA, USA. jtorma@mines.edu
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 351
EP  - 359
VL  - 14
IS  - 3
SN  - 1080-3548, 1080-3548
KW  - Index Medicus
KW  - Musculoskeletal Diseases -- prevention & control
KW  - Humans
KW  - Occupational Diseases -- prevention & control
KW  - Program Development
KW  - Wisconsin
KW  - Occupational Health
KW  - Task Performance and Analysis
KW  - Mining
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-11-25
N1  - Date created - 2008-10-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Preventable mix-ups of tuberculin and vaccines: reports to the US Vaccine and Drug Safety Reporting Systems.
AN  - 69646565; 18840022
AB  - Errors involving the mix-up of tuberculin purified protein derivative (PPD) and vaccines leading to adverse reactions and unnecessary medical management have been reported previously.
          To determine the frequency of PPD-vaccine mix-ups reported to the US Vaccine Adverse Event Reporting System (VAERS) and the Adverse Event Reporting System (AERS), characterize adverse events and clusters involving mix-ups and describe reported contributory factors. We reviewed AERS reports from 1969 to 2005 and VAERS reports from 1990 to 2005. We defined a mix-up error event as an incident in which a single patient or a cluster of patients inadvertently received vaccine instead of a PPD product or received a PPD product instead of vaccine. We defined a cluster as inadvertent administration of PPD or vaccine products to more than one patient in the same facility within 1 month. Of 115 mix-up events identified, 101 involved inadvertent administration of vaccines instead of PPD. Product confusion involved PPD and multiple vaccines. The annual number of reported mix-ups increased from an average of one event per year in the early 1990s to an average of ten events per year in the early part of this decade. More than 240 adults and children were affected and the majority reported local injection site reactions. Four individuals were hospitalized (all recovered) after receiving the wrong products. Several patients were inappropriately started on tuberculosis prophylaxis as a result of a vaccine local reaction being interpreted as a positive tuberculin skin test. Reported potential contributory factors involved both system factors (e.g. similar packaging) and human errors (e.g. failure to read label before product administration).
          To prevent PPD-vaccine mix-ups, proper storage, handling and administration of vaccine and PPD products is necessary.
JF  - Drug safety
AU  - Chang, Soju
AU  - Pool, Vitali
AU  - O'Connell, Kathryn
AU  - Polder, Jacquelyn A
AU  - Iskander, John
AU  - Sweeney, Colleen
AU  - Ball, Robert
AU  - Braun, M Miles
AD  - Office of Biostatistics and Epidemiology, US Food and Drug Administration (FDA), 1401 Rockville Pike, Rockville, MD 20852, USA. sojuchang@hotmail.com
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 1027
EP  - 1033
VL  - 31
IS  - 11
SN  - 0114-5916, 0114-5916
KW  - Tuberculin
KW  - 0
KW  - Vaccines
KW  - Index Medicus
KW  - Young Adult
KW  - Humans
KW  - Aged
KW  - Child
KW  - Child, Preschool
KW  - Infant
KW  - Adverse Drug Reaction Reporting Systems
KW  - Aged, 80 and over
KW  - Adult
KW  - Product Surveillance, Postmarketing
KW  - Databases, Factual
KW  - Middle Aged
KW  - Adolescent
KW  - Hospitalization -- statistics & numerical data
KW  - United States -- epidemiology
KW  - Male
KW  - Female
KW  - Vaccines -- adverse effects
KW  - Tuberculin -- adverse effects
KW  - Medication Errors -- prevention & control
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2009-01-30
N1  - Date created - 2008-10-08
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - A comparison of false positive rates of peto and poly-3 methods for long-term carcinogenicity data analysis using multiple comparison adjustment method suggested by Lin and Rahman.
AN  - 69536085; 18781527
AB  - Statistical analyses of two-year carcinogenicity data include tests for dose-response relationship (positive trend) among the increasing doses and pairwise comparisons of treated groups with control in tumor incidence by organ/tumor combination. There are two major concerns in analyzing carcinogenicity data, namely, adjustment for the difference in mortality due to drug toxicity and adjustment for the multiplicity due to multiple testing of trends and pairwise differences by organ tumor combination. A widely used method for testing dose-response relationship is the method suggested by Peto et al. (Peto test). The Peto test adjusts the mortality differences among treatment groups by partitioning the entire study period into several intervals, analyzing the data separately for each interval, and then combining them using the Mantel-Haenszel procedure. The denominator for the calculation of the proportion of tumor bearing animals is determined from the cause of death information tumor data. In later works, researchers have expressed concerns regarding the construction of suitable intervals for mortality adjustment. Also according to the opinion of many pathologists it is difficult to accurately specify retrospectively if a tumor is the real cause of death of an animal. This information may be imprecise. Hence, many times results of analysis using the Peto test are questioned due to the inaccurate cause of death information. An alternative to the Peto test was suggested by Bailer and Portier, popularly known as Poly-K test. Unlike the Peto test, this test does not need any arbitrary partitioning of the study period or the cause of death information. This test for trend in tumor incidence adjusts the differences in mortality among treatment groups by assigning a weight of less than one to an animal that died early without developing the tumor; and a weight of one to an animal that died with the tumor or survived to the end of the study. The sum of the assigned weights of animals in a treatment group is then used as the denominator for the calculation of proportion of tumor-bearing animals for the group. The less-than-one weight assigned to an animal is the fraction of the animal's surviving time in the study over the maximum time of the study with a power k. The power k of the fraction is determined by the distribution of tumor onset times of the tumor. The Poly-K test may have some advantages over the Peto test in the sense that it does not require the cause of death information, which is an essential part for the Peto test. However, the performance of the Poly-K test in controlling the false positive rate in comparison to the Peto test is unknown and of great interest in the regulatory environment. In this work the authors compared the overall false positive rates of the Peto and Poly-K tests using the Lin-Rahman multiple comparison adjustment based on some simulation results.
JF  - Journal of biopharmaceutical statistics
AU  - Rahman, Mohammad A
AU  - Lin, Karl K
AD  - Division of Biometrics 6, Office of Biostatistics/Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. mohammad.rahman@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 949
EP  - 958
VL  - 18
IS  - 5
KW  - Index Medicus
KW  - Animals
KW  - Neoplasms, Experimental -- chemically induced
KW  - Dose-Response Relationship, Drug
KW  - Neoplasms, Experimental -- mortality
KW  - Carcinogenicity Tests -- methods
KW  - Data Interpretation, Statistical
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-11-25
N1  - Date created - 2008-09-10
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/10543400802287628
ER  - 



TY  - JOUR
T1  - Identifying high-dimensional biomarkers for personalized medicine via variable importance ranking.
AN  - 69534717; 18781521
AB  - We apply robust classification algorithms to high-dimensional genomic data to find biomarkers, by analyzing variable importance, that enable a better diagnosis of disease, an earlier intervention, or a more effective assignment of therapies. The goal is to use variable importance ranking to isolate a set of important genes that can be used to classify life-threatening diseases with respect to prognosis or type to maximize efficacy or minimize toxicity in personalized treatment of such diseases. A ranking method and present several other methods to select a set of important genes to use as genomic biomarkers is proposed, and the performance of the selection procedures in patient classification by cross-validation is evaluated. The various selection algorithms are applied to published high-dimensional genomic data sets using several well-known classification methods. For each data set, a set of genes selected on the basis of variable importance that performed the best in classification is reported. That classification algorithm with the proposed ranking method is shown to be competitive with other selection methods for discovering genomic biomarkers underlying both adverse and efficacious outcomes for improving individualized treatment of patients for life-threatening diseases.
JF  - Journal of biopharmaceutical statistics
AU  - Baek, Songjoon
AU  - Moon, Hojin
AU  - Ahn, Hongshik
AU  - Kodell, Ralph L
AU  - Lin, Chien-Ju
AU  - Chen, James J
AD  - Division of Personalized Nutrition and Medicine-Biometry Branch, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA.
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 853
EP  - 868
VL  - 18
IS  - 5
KW  - Biomarkers
KW  - 0
KW  - Index Medicus
KW  - Oligonucleotide Array Sequence Analysis
KW  - Humans
KW  - Prognosis
KW  - Leukemia, Myeloid, Acute -- mortality
KW  - Lymphoma -- classification
KW  - Lymphoma -- genetics
KW  - Leukemia, Myeloid, Acute -- genetics
KW  - Algorithms
KW  - Genomics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-11-25
N1  - Date created - 2008-09-10
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/10543400802278023
ER  - 



TY  - JOUR
T1  - Summary health statistics for the U.S. population: National Health Interview Survey, 2006.
AN  - 69317928; 18624012
AB  - This report presents both age-adjusted and unadjusted health statistics from the 2006 National Health Interview Survey (NHIS) for the civilian noninstitutionalized population of the United States, classified by sex, age, race, Hispanic or Latino origin and race, education, family income, poverty status, health insurance coverage (where appropriate), place of residence, and region of residence. The topics covered are respondent-assessed health status, limitations in activities, special education or early intervention services, injury and poisoning episodes, health care access and utilization, and health insurance coverage.
          NHIS is a household, multistage probability sample survey conducted annually by interviewers of the U.S. Census Bureau for the Centers for Disease Control and Prevention's National Center for Health Statistics. In 2006, household interviews were completed for 75,716 persons living in 29,204 households, reflecting a household response rate of 87.3%. Nearly 7 in 10 persons were in excellent or very good health in 2006. About 36 million persons (12%) were limited in their usual activities due to one or more chronic health conditions. About 4 million persons (2%) required the help of another person with activities of daily living, and about 8 million persons (4%) required the help of another person with instrumental activities of daily living. About 6% of children received special education or early intervention services. Among persons under age 65 years, about 43 million (17%) did not have any health insurance coverage. The most common reason for lacking health insurance was cost, followed by a change in employment.
JF  - Vital and health statistics. Series 10, Data from the National Health Survey
AU  - Adams, Patricia F
AU  - Lucas, Jacqueline Wilson
AU  - Barnes, Patricia M
AD  - Division of Health Interview Statistics, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, Maryland 20782, USA.
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 1
EP  - 104
IS  - 236
SN  - 0083-1972, 0083-1972
KW  - Index Medicus
KW  - Wounds and Injuries -- epidemiology
KW  - Humans
KW  - Poisoning -- epidemiology
KW  - Activities of Daily Living
KW  - Aged
KW  - Child
KW  - Child, Preschool
KW  - Demography
KW  - Infant
KW  - Education, Special -- statistics & numerical data
KW  - Adult
KW  - Middle Aged
KW  - Adolescent
KW  - United States -- epidemiology
KW  - Female
KW  - Male
KW  - Insurance Coverage -- statistics & numerical data
KW  - Health Surveys
KW  - Health Status
KW  - Health Services Accessibility -- statistics & numerical data
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-08-05
N1  - Date created - 2008-07-15
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - To ban or not to ban--that is the question: the constitutionality of a moratorium on consumer drug advertising.
AN  - 69221723; 18561453
JF  - Food and drug law journal
AU  - Schwartz, Mark I
AD  - Food and Drug Administration, USA.
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 1
EP  - 33
VL  - 63
IS  - 1
SN  - 1064-590X, 1064-590X
KW  - Pharmaceutical Preparations
KW  - 0
KW  - Health technology assessment
KW  - United States
KW  - United States Food and Drug Administration
KW  - Supreme Court Decisions
KW  - Government Regulation
KW  - Humans
KW  - Drug-Related Side Effects and Adverse Reactions
KW  - Pharmaceutical Preparations -- economics
KW  - Community Participation
KW  - International Agencies
KW  - Guidelines as Topic
KW  - Patient Education as Topic -- legislation & jurisprudence
KW  - Drug Industry -- standards
KW  - Civil Rights -- legislation & jurisprudence
KW  - Advertising as Topic -- legislation & jurisprudence
KW  - Advertising as Topic -- standards
KW  - Legislation, Drug
KW  - Drug Industry -- legislation & jurisprudence
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-06-26
N1  - Date created - 2008-06-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Statistical issues including design and sample size calculation in thorough QT/QTc studies.
AN  - 69205031; 18470755
AB  - After several drugs were removed from the market in recent years because of death due to ventricular tachycardia resulting from drug-induced QT prolongation (Khongphatthanayothin et al., 1998; Lasser et al., 2002; Pratt et al., 1994; Wysowski et al., 2001), the ICH Regulatory agencies requested all sponsors of new drugs to conduct a clinical study, named a Thorough QT/QTc (TQT) study, to assess any possible QT prolongation due to the study drug. The final version of the ICH E14 guidance (ICH, 2005) for "The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Nonantiarrhythmic Drugs" was released in May 2005. The purpose of the ICH E14 guidance (ICH, 2005) is to provide recommendations to sponsors concerning the design, conduct, analysis, and interpretation of clinical studies to assess the potential of a drug to delay cardiac repolarization. The guideline, however, is not specific on several issues. In this paper, we try to address some statistical issues, including study design, primary statistical analysis, assay sensitivity analysis, and the calculation of the sample size for a TQT study.
JF  - Journal of biopharmaceutical statistics
AU  - Zhang, Joanne
AU  - Machado, Stella G
AD  - Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Joanne.Zhang@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 451
EP  - 467
VL  - 18
IS  - 3
KW  - Drugs, Investigational
KW  - 0
KW  - Index Medicus
KW  - International Cooperation
KW  - Humans
KW  - Sample Size
KW  - Electrocardiography -- statistics & numerical data
KW  - Research Design -- statistics & numerical data
KW  - Heart Rate -- drug effects
KW  - Long QT Syndrome -- chemically induced
KW  - Long QT Syndrome -- diagnosis
KW  - Heart Rate -- physiology
KW  - Drugs, Investigational -- adverse effects
KW  - Long QT Syndrome -- physiopathology
KW  - Guidelines as Topic
KW  - Randomized Controlled Trials as Topic -- statistics & numerical data
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69205031?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Statistical+issues+including+design+and+sample+size+calculation+in+thorough+QT%2FQTc+studies.&rft.au=Zhang%2C+Joanne%3BMachado%2C+Stella+G&rft.aulast=Zhang&rft.aufirst=Joanne&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400802020938
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-06-27
N1  - Date created - 2008-05-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/10543400802020938
ER  - 



TY  - JOUR
T1  - Validation testing in thorough QT/QTc clinical trials.
AN  - 69204374; 18470761
AB  - In order to validate the results of a thorough QT/QTc (the duration of depolarization and repolarization of ventricles or the duration corrected for heart rate) clinical trial, ICH E14 recommended to include a concurrent positive control treatment in the trial. It further recommended that validation is achieved if the positive control has an effect on the mean QT/QTc interval of about 5 ms. Zhang (2008) discussed the intersection-union test approach for testing the validation hypotheses and an alternative global average test approach. In this article, we further discuss the difference and relationship of the two sets of hypotheses and the difference in the efficiencies of the two approaches. We conclude that validation can be achieved if either one test rejects the null hypotheses without inflating the family-wise Type I error rate. However, using both approaches may improve the efficiency in validation assessment.
JF  - Journal of biopharmaceutical statistics
AU  - Tsong, Yi
AU  - Zhong, Jinglin
AU  - Chen, Wen Jen
AD  - Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. yi.tsong@cder.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 529
EP  - 541
VL  - 18
IS  - 3
KW  - Anti-Infective Agents
KW  - 0
KW  - Aza Compounds
KW  - Fluoroquinolones
KW  - Placebos
KW  - Quinolines
KW  - moxifloxacin
KW  - U188XYD42P
KW  - Index Medicus
KW  - Control Groups
KW  - Anti-Infective Agents -- adverse effects
KW  - Humans
KW  - Aza Compounds -- adverse effects
KW  - Guidelines as Topic
KW  - Quinolines -- adverse effects
KW  - Validation Studies as Topic
KW  - Electrocardiography -- standards
KW  - Heart Rate -- drug effects
KW  - Long QT Syndrome -- chemically induced
KW  - Long QT Syndrome -- diagnosis
KW  - Heart Rate -- physiology
KW  - Long QT Syndrome -- physiopathology
KW  - Randomized Controlled Trials as Topic -- statistics & numerical data
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-06-27
N1  - Date created - 2008-05-12
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
J Biopharm Stat. 2010 May;20(3):683-7; author reply 688 [20358445]
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/10543400801995486
ER  - 



TY  - JOUR
T1  - Statistical issues of QT prolongation assessment based on linear concentration modeling.
AN  - 69203431; 18470764
AB  - The ICH (2005) defined drug-induced prolongation of QT interval, i.e., the duration of depolarization and repolarization of ventricles, as evidenced by an upper bound of the 95% confidence interval around the mean effect on QTc (QT corrected for heart rate) of 10 ms. Furthermore, it defined that a negative thorough QT/QTc study is one in which the upper bound of the 95% one-sided confidence interval for the largest time-matched mean effect of the drug on the QTc interval excludes 10 ms. This objective leads to the application of intersection-union tests by testing the mean difference between test treatment and placebo of QTc change from baseline at each of the matched time points at which the observations are collected. The nature of the higher false positive rate due to more observational time points leads to the concern of study efficiency. Based on the concept of clinical pharmacology, a concentration-response modeling approach is often adopted to assess the prolongation size of QTc interval induced by a drug without carefully examining the validity of the assumptions involved. In most of the applications, the model is assumed either to be linear, log-linear, or logistic. The supporter of the modeling often emphasizes the advantage of power improvement and reduction in estimation error. However, it has been often pointed out by statisticians and pharmacologists that modeling under an invalid uniformity assumption across study population often leads to severe bias in testing and estimation. In this article, we examine data sets of New Drug Applications to illustrate the bias and lack of validity of the linearity assumptions.
JF  - Journal of biopharmaceutical statistics
AU  - Tsong, Yi
AU  - Shen, Meiyu
AU  - Zhong, Jinglin
AU  - Zhang, Joanne
AD  - Division of Biometrics VI, Office of Biostatistics/Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. yi.tsong@cder.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 564
EP  - 584
VL  - 18
IS  - 3
KW  - Anti-Infective Agents
KW  - 0
KW  - Aza Compounds
KW  - Fluoroquinolones
KW  - Quinolines
KW  - moxifloxacin
KW  - U188XYD42P
KW  - Index Medicus
KW  - Humans
KW  - Linear Models
KW  - Aza Compounds -- administration & dosage
KW  - Quinolines -- adverse effects
KW  - Quinolines -- administration & dosage
KW  - Anti-Infective Agents -- adverse effects
KW  - International Cooperation
KW  - Anti-Infective Agents -- administration & dosage
KW  - Aza Compounds -- adverse effects
KW  - Guidelines as Topic
KW  - Sample Size
KW  - Time Factors
KW  - Electrocardiography -- standards
KW  - Heart Rate -- drug effects
KW  - Long QT Syndrome -- chemically induced
KW  - Long QT Syndrome -- diagnosis
KW  - Heart Rate -- physiology
KW  - Long QT Syndrome -- physiopathology
KW  - Randomized Controlled Trials as Topic -- statistics & numerical data
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-06-27
N1  - Date created - 2008-05-12
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
J Biopharm Stat. 2010 May;20(3):689-92; author reply 693-7 [20358447]
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/10543400801995502
ER  - 



TY  - JOUR
T1  - Testing for positive control activity in a thorough QTc study.
AN  - 69202550; 18470760
AB  - The ICH E14 guidance (ICH, 2005) recommend that a concurrent positive control should be included in a thorough QTc clinical trial to validate the study. The ICH E14 guidance (ICH, 2005) state that "The positive control should have an effect on the mean QTc interval of about 5 ms (i.e., an effect that is close to the QTc effect that represents the threshold of regulatory concern, around 5 ms)". This task may be carried out through some statistical tests. The current practice is to test at each time point where QT measurements are collected. This method is usually not efficient. In this article, I discuss two types of statistical procedures. The first one is a local statistical test to make a time-point-specific claim, i.e., to claim a mild QTc effect due to the positive control at some specific time points. A different approach, named as a global test, is also proposed, to make a general claim that the mean difference of the positive control and placebo after baseline adjustment will be about 5 ms without specifying at which time points. An example will be used to illustrate how to apply the two procedures. How to best allocate sample size in a parallel QTc study is also discussed in this paper.
JF  - Journal of biopharmaceutical statistics
AU  - Zhang, Joanne
AD  - Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Joanne.Zhang@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 517
EP  - 528
VL  - 18
IS  - 3
KW  - Index Medicus
KW  - Humans
KW  - Electrocardiography -- standards
KW  - Research Design -- statistics & numerical data
KW  - Heart Rate -- drug effects
KW  - Long QT Syndrome -- chemically induced
KW  - Control Groups
KW  - Long QT Syndrome -- diagnosis
KW  - Heart Rate -- physiology
KW  - Long QT Syndrome -- physiopathology
KW  - Randomized Controlled Trials as Topic -- statistics & numerical data
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Testing+for+positive+control+activity+in+a+thorough+QTc+study.&rft.au=Zhang%2C+Joanne&rft.aulast=Zhang&rft.aufirst=Joanne&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400801995478
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-06-27
N1  - Date created - 2008-05-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/10543400801995478
ER  - 



TY  - JOUR
T1  - Guest editors' notes on statistical issues in design and analysis of thorough QTc studies.
AN  - 69202047; 18470752
JF  - Journal of biopharmaceutical statistics
AU  - Tsong, Yi
AU  - Zhang, Joanne
AD  - Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. yi.tsong@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 405
EP  - 407
VL  - 18
IS  - 3
KW  - Placebos
KW  - 0
KW  - Index Medicus
KW  - Heart Rate -- drug effects
KW  - Humans
KW  - Heart Rate -- physiology
KW  - Electrocardiography -- statistics & numerical data
KW  - Research Design -- statistics & numerical data
KW  - Long QT Syndrome -- chemically induced
KW  - Long QT Syndrome -- diagnosis
KW  - Long QT Syndrome -- physiopathology
KW  - Clinical Trials as Topic -- statistics & numerical data
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Guest+editors%27+notes+on+statistical+issues+in+design+and+analysis+of+thorough+QTc+studies.&rft.au=Tsong%2C+Yi%3BZhang%2C+Joanne&rft.aulast=Tsong&rft.aufirst=Yi&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400802029509
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-06-27
N1  - Date created - 2008-05-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1080/10543400802029509
ER  - 



TY  - JOUR
T1  - Mining sector.
AN  - 69180082; 18454967
JF  - Journal of safety research
AU  - Bealko, Susan B
AU  - Kovalchik, Peter G
AU  - Matetic, Rudy J
AD  - National Institute for Occupational Safety and Health (NIOSH), USA. sbealko@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 187
EP  - 189
VL  - 39
IS  - 2
SN  - 0022-4375, 0022-4375
KW  - Index Medicus
KW  - Organizational Policy
KW  - Humans
KW  - Organizational Culture
KW  - Occupational Health
KW  - Environment Design
KW  - Accidents, Occupational -- prevention & control
KW  - Workplace
KW  - Mining
KW  - Safety Management
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69180082?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+safety+research&rft.atitle=Mining+sector.&rft.au=Bealko%2C+Susan+B%3BKovalchik%2C+Peter+G%3BMatetic%2C+Rudy+J&rft.aulast=Bealko&rft.aufirst=Susan&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Journal+of+safety+research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.004
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-08-15
N1  - Date created - 2008-05-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1016/j.jsr.2008.02.004
ER  - 



TY  - JOUR
T1  - National Prevention through Design (PtD) Initiative.
AN  - 69174412; 18454950
AB  - The most effective means of preventing and controlling occupational injuries, illness, and fatalities is to "design out" hazards and hazardous exposures from the workplace. There is a long history of designing for safety for the general public and to a lesser degree for workers.
          We now have the experience and insight from thoughtful, previous efforts to call for a comprehensive national strategy to implement a Prevention through Design (PtD) Initiative. This paper describes that initiative in terms of four overarching areas where action can be directed: practice, policy, research, and education. To obtain stakeholder input for issues in these four areas and to focus implementation efforts, eight sector divisions of the economy will be addressed. A seven year strategy is envisioned.
JF  - Journal of safety research
AU  - Schulte, Paul A
AU  - Rinehart, Richard
AU  - Okun, Andrea
AU  - Geraci, Charles L
AU  - Heidel, Donna S
AD  - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, USA. pas4@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 115
EP  - 121
VL  - 39
IS  - 2
SN  - 0022-4375, 0022-4375
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Public Policy
KW  - Occupational Health
KW  - Accidents, Occupational -- prevention & control
KW  - Safety Management -- standards
KW  - Environment Design -- standards
KW  - Workplace -- standards
KW  - Program Development
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69174412?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+safety+research&rft.atitle=National+Prevention+through+Design+%28PtD%29+Initiative.&rft.au=Schulte%2C+Paul+A%3BRinehart%2C+Richard%3BOkun%2C+Andrea%3BGeraci%2C+Charles+L%3BHeidel%2C+Donna+S&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Journal+of+safety+research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.021
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-08-15
N1  - Date created - 2008-05-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1016/j.jsr.2008.02.021
ER  - 



TY  - JOUR
T1  - Quality control of microarray assays for toxicogenomic and in vitro diagnostic applications.
AN  - 69160134; 18449482
AB  - The generation of high-quality microarray data for toxicogenomics can be affected by the study design and methods used for sample acquisition, preparation, and processing. Bias can be introduced during animal treatment, tissue handling, and sample preparation. Metrics and controls used in assessing RNA integrity and the quality of microarray sample generation are reviewed in this chapter. Regulations and guidelines involved in the application of microarrays as a commercial in vitro diagnostic device are also described.
JF  - Methods in molecular biology (Clifton, N.J.)
AU  - Thompson, Karol L
AU  - Hackett, Joseph
AD  - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 45
EP  - 68
VL  - 460
SN  - 1064-3745, 1064-3745
KW  - Index Medicus
KW  - Oligonucleotide Array Sequence Analysis
KW  - Humans
KW  - In Vitro Techniques
KW  - Diagnostic Tests, Routine
KW  - Quality Control
KW  - Toxicology
KW  - Genomics
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69160134?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Quality+control+of+microarray+assays+for+toxicogenomic+and+in+vitro+diagnostic+applications.&rft.au=Thompson%2C+Karol+L%3BHackett%2C+Joseph&rft.aulast=Thompson&rft.aufirst=Karol&rft.date=2008-01-01&rft.volume=460&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-60327-048-9_3
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-08-05
N1  - Date created - 2008-05-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1007/978-1-60327-048-9_3
ER  - 



TY  - JOUR
T1  - Informatic tools and approaches in postmarketing pharmacovigilance used by FDA.
AN  - 69157025; 18446503
AB  - The safety profile of newly approved drugs and therapeutic biologics is less well developed by pre-marketing clinical testing than is the efficacy profile. The full safety profile of an approved product is established during years of clinical use. For nearly 40 years, the FDA has relied on the voluntary reporting of adverse events by healthcare practitioners and patients to help establish the safety of marketed products. Epidemiologic studies, including case series, secular trends, case-control and cohort studies, are used to supplement the investigation of a safety signal. Ideally, active surveillance systems would supplement the identification and exploration of safety signals. The FDA has implemented a number of initiatives to help identify safety problems with drugs and continues to evaluate their efforts.
JF  - The AAPS journal
AU  - Weaver, Joyce
AU  - Willy, Mary
AU  - Avigan, Mark
AD  - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20903-0002, USA. joyce.weaver@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 35
EP  - 41
VL  - 10
IS  - 1
KW  - Drugs, Investigational
KW  - 0
KW  - Index Medicus
KW  - United States
KW  - Drugs, Investigational -- pharmacology
KW  - Animals
KW  - Adverse Drug Reaction Reporting Systems -- standards
KW  - Humans
KW  - Adverse Drug Reaction Reporting Systems -- trends
KW  - Drugs, Investigational -- adverse effects
KW  - Medical Informatics -- trends
KW  - United States Food and Drug Administration -- trends
KW  - Medical Informatics -- standards
KW  - United States Food and Drug Administration -- standards
KW  - Product Surveillance, Postmarketing -- trends
KW  - Product Surveillance, Postmarketing -- standards
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Informatic+tools+and+approaches+in+postmarketing+pharmacovigilance+used+by+FDA.&rft.au=Weaver%2C+Joyce%3BWilly%2C+Mary%3BAvigan%2C+Mark&rft.aulast=Weaver&rft.aufirst=Joyce&rft.date=2008-01-01&rft.volume=10&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-007-9004-5
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-09-22
N1  - Date created - 2008-04-30
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Drug Saf. 2002;25(6):381-92 [12071774]
Drug Saf. 2003;26(3):159-86 [12580646]
Hepatology. 2004 Oct;40(4):773 [15382161]
J R Soc Med. 1991 Jun;84(6):341-4 [2061900]
JAMA. 2006 Oct 18;296(15):1858-66 [17047216]
Chest. 2006 Jan;129(1):15-26 [16424409]
N Engl J Med. 2006 Mar 2;354(9):924-33 [16510746]
Arch Gen Psychiatry. 2006 Mar;63(3):332-9 [16520440]
Basic Clin Pharmacol Toxicol. 2006 Mar;98(3):311-3 [16611207]
Drug Saf. 2005;28(10):917-24 [16180941]
N1  - Last updated - 2017-01-18
DO  - http://dx.doi.org/10.1208/s12248-007-9004-5
ER  - 



TY  - RPRT
T1  - National Survey of Child and Adolescent Well-Being, No. 12: Estimates of Supplemental Security Income Eligibility for Children in Out-of-Home Placements. Research Brief: Findings from the NSCAW Study
AN  - 61960813; ED501307
AB  - Children who have been placed in foster care have been found to be at a high risk of having a medical, social or behavioral disability. This brief, one in a series of briefs addressing access to services for children in the child welfare system, examines Supplemental Security Income (SSI) eligibility among children living in out-of-home placements in the child welfare system, using data from the National Survey of Child and Adolescent Well-Being. The analysis indicates that a large number of children living in foster care may be eligible for SSI. The rates of SSI eligibility we estimate vary depending on children's age, race/ethnicity, gender and locality of placement. (Contains 4 tables and 11 notes.)
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 8
PB  - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201.
KW  - ERIC, Resources in Education (RIE)
KW  - At Risk Persons
KW  - Gender Differences
KW  - Place of Residence
KW  - Welfare Services
KW  - Racial Differences
KW  - Foster Care
KW  - Child Welfare
KW  - Age Differences
KW  - Eligibility
KW  - Placement
KW  - Income
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61960813?accountid=14244
LA  - English
DB  - ERIC
N1  - Last updated - 2014-03-21
ER  - 



TY  - BOOK
T1  - Monitoring and Technical Assistance Review System Notebook
AN  - 61959051; ED501839
AB  - This notebook provides guidance on the Monitoring and Technical Assistance Review System (MTARS). The manual is intended for use by Administration on Developmental Disabilities (ADD) staff who manage MTARS and by MTARS reviewers who conduct site visit activities. The notebook is also designed to help Councils, Protection and Advocacy Systems, and University Centers for Excellence in Developmental Disabilities prepare for and participate in MTARS activities. The notebook describes procedures for each stage of the MTARS process and is organized into seven sections: (1) Overview of the Developmental Disabilities Assistance and Bill of Rights Act of 2000 (DD Act) and ADD; (2) Monitoring and Technical Assistance Review System; (3) MTARS Team; (4) Planning Activities; (5) Pre-Site Visit Activities; (6) MTARS Site Visit; and (7) Post-Site Visit Activities. Tables, checklists, glossary and additional information are appended. (Contains 31 tables.)
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 223
PB  - Administration for Children & Families. U.S. Department of Health and Human Services, 380 L'Enfant Promenade SW, Washington, DC 20447.
KW  - Developmental Disabilities Act
KW  - Developmental Disabled Assist Bill of Rights Act
KW  - ERIC, Resources in Education (RIE)
KW  - Administrators
KW  - Self Evaluation (Individuals)
KW  - Developmental Disabilities
KW  - Grants
KW  - Observation
KW  - Evaluators
KW  - Accountability
KW  - Human Services
KW  - Federal Legislation
KW  - Public Agencies
KW  - Innovation
KW  - Planning
KW  - Check Lists
KW  - Compliance (Legal)
KW  - Program Evaluation
KW  - Technical Assistance
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61959051?accountid=14244
LA  - English
DB  - ERIC
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - More about the Dads: Exploring Associations between Nonresident Father Involvement and Child Welfare Case Outcomes
AN  - 61947640; ED501299
AB  - This study follows up on a prior study of child welfare agencies' efforts to identify, locate, and involve nonresident fathers of children in foster care. These analyses use information from the original survey and administrative data on case outcomes to explore three research questions: (1) Is nonresident father involvement associated with case length? (2) Is nonresident father involvement associated with foster care discharge outcomes? and (3) Is nonresident father involvement associated with subsequent child maltreatment allegations? The study finds that having an involved father is associated with shorter case length and a greater likelihood of reunification. Findings also indicate that, contrary to some caseworkers' fears, nonresident fathers' contact with the child welfare agency and involvement with their children is not associated with subsequent maltreatment allegations. The results, though exploratory, suggest that engaging the nonresident fathers of children in foster care could potentially improve outcomes for the children. Further research is needed to better understand the association between nonresident fathers' involvement and a greater likelihood of reunification. (Contains 2 tables, 7 figures, and 34 footnotes.) [This report was prepared by the Urban Institute under contract to the Office of the Assistant Secretary for Planning and Evaluation of the U.S. Department of Health and Human Services.]
AU  - Malm, Karin
AU  - Zielewski, Erica
AU  - Chen, Henry
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 30
PB  - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201.
KW  - ERIC, Resources in Education (RIE)
KW  - Followup Studies
KW  - Parent Child Relationship
KW  - Welfare Services
KW  - Child Abuse
KW  - Fathers
KW  - Child Welfare
KW  - Foster Care
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61947640?accountid=14244
LA  - English
DB  - ERIC
N1  - Last updated - 2014-03-21
ER  - 



TY  - GEN
T1  - Substance Abuse and Mental Health Services Administration. March/April 2008
AN  - 61947049; ED501549
AB  - "SAMHSA News" is the national newsletter of the Substance Abuse and Mental Health Services Administration. Published six times a year (bimonthly) by SAMHSA's Office of Communications, SAMHSA News contains information about the latest substance abuse and mental health treatment and prevention practices, recent statistics on mental health and addictive disorders, related Federal policies, and available resources. Articles in this issue include: (1) Screening Works: Update from the Field (Rebecca A. Clay); (2) Administrator's Message: Behavioral Health Screening and Primary Care (Terry L. Cline); (3) Screening in Action: For SBIRT Grantees Across the Nation, Flexibility Helps (Rebecca A. Clay); (4) President's Budget Focuses on Priority Initiatives; (5) Teens and Drug Use: Stimulant Use and Delinquent Behavior; (6) Statistics on Inhalants Show Young Teens at Risk; (7) State by State: Substance Use, Mental Health Statistics; (8) New Data on Treatment Admissions: Alcohol Abuse Highest, but Methamphetamine, Marijuana, Prescription Painkillers on the Rise; (9) Study Helps Dispel Substance Use Myth: Rural Communities at Risk (Erin Bryant); and (10) Making Workplaces Drug-Free.
AU  - Goodman, Deborah
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 16
PB  - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov
VL  - 16
IS  - 2
KW  - ERIC, Resources in Education (RIE)
KW  - At Risk Persons
KW  - Substance Abuse
KW  - Statistics
KW  - Delinquency
KW  - Grants
KW  - Mental Health Programs
KW  - Stimulants
KW  - Mental Health
KW  - Marijuana
KW  - Behavior Problems
KW  - Rural Areas
KW  - Screening Tests
KW  - Health Services
KW  - Alcohol Abuse
KW  - Inhalants
KW  - Misconceptions
KW  - Occupational Safety and Health
KW  - Incidence
KW  - Budgets
KW  - Work Environment
KW  - Adolescents
KW  - Drug Abuse
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61947049?accountid=14244
LA  - English
DB  - ERIC
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - Connecting Social and Emotional Learning with Mental Health
AN  - 61893862; ED505361
AB  - As knowledge of effective treatments for mental disorders has grown, so too has the field of mental health promotion and positive development. Studies completed during the last two decades have synthesized the state of mental health promotion and documented that universal mental health supports positively affect child and adolescent developmental outcomes. Given schools' ability to access large numbers of children, they are commonly identified as the best place to provide supports to promote the universal mental health of children. This report explains the relationship between mental health and the promotion of social and emotional learning (SEL). Strategies for connecting mental health and SEL in the school setting include: (1) Implementing supportive public policies; (2) Developing safe, caring, and supportive environments; (3) Providing direct instruction for students on skills and strategies; (4) Creating infrastructure for community action; and (5) Coordinating with community agencies, schools, families, and students to create a common vision, language, and coordinated services to support healthy outcomes. A list of resources is included.
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 9
PB  - Collaborative for Academic, Social, and Emotional Learning. 815 West Van Buren Street Suite 210, Chicago, IL 60607.
KW  - ERIC, Resources in Education (RIE)
KW  - Elementary Secondary Education
KW  - Program Effectiveness
KW  - Community Action
KW  - Guidelines
KW  - Child Health
KW  - Mental Health
KW  - Public Policy
KW  - Emotional Development
KW  - Health Promotion
KW  - Educational Environment
KW  - Public Health
KW  - Public Agencies
KW  - Mental Disorders
KW  - Program Implementation
KW  - School Role
KW  - Program Development
KW  - Social Development
KW  - Program Evaluation
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61893862?accountid=14244
LA  - English
DB  - ERIC
N1  - Last updated - 2014-03-21
ER  - 



TY  - RPRT
T1  - Social and Emotional Learning (SEL) and Student Benefits: Implications for the Safe Schools/Healthy Students Core Elements
AN  - 61890878; ED505369
AB  - This brief shares the latest research on the effects of social and emotional learning (SEL) on students and includes strategies for implementing SEL. It explains how SEL works, elaborates on how SEL can be an integrative prevention framework that addresses the Safe Schools/Healthy Students (SS/HS) core elements, and spells out implications of the research for SS/HS grantees. Several hundred well-designed studies have documented the effects of SEL programming on students of diverse backgrounds, from preschool through high school, in urban, suburban, and rural settings. The research indicates that well-planned and well-implemented SEL programming can positively affect a broad range of student social, health, behavioral, and academic outcomes. (Contains 22 endnotes, 1 figure and 1 table.)
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 12
PB  - Collaborative for Academic, Social, and Emotional Learning. 815 West Van Buren Street Suite 210, Chicago, IL 60607.
KW  - ERIC, Resources in Education (RIE)
KW  - Elementary Secondary Education
KW  - Program Effectiveness
KW  - Research Reports
KW  - Child Health
KW  - School Safety
KW  - Emotional Development
KW  - Outcomes of Education
KW  - Prevention
KW  - Educational Environment
KW  - Program Implementation
KW  - Federal Programs
KW  - Program Development
KW  - Social Development
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61890878?accountid=14244
LA  - English
DB  - ERIC
N1  - Last updated - 2014-03-21
ER  - 



TY  - JOUR
T1  - U.S. Health Spending By Age, Selected Years Through 2004: Recent trends indicate that per person spending for the oldest elderly is growing more slowly than spending for all other age groups
AN  - 58774822; 2008-171174
AB  - This paper examines variations in health spending by children, working-age adults, and seniors for selected years between 1987 and 2004. Seniors spent far more per person than children or working-age adults, but the relative gap between the age groups has not changed much since 1987 except for those age eighty-five and older. Since the inception of the State Children's Health Insurance Program (SCHIP) in 1997, the proportion of children's health spending financed by public sources has increased, while the share paid for out of pocket has decreased. The future age-mix is expected to have a major impact on nursing home spending growth while minimally affecting overall Medicare spending growth. Adapted from the source document.
JF  - Health Affairs
AU  - Hartman, Micah
AU  - Catlin, Aaron
AU  - Lassman, David
AU  - Cylus, Jonathan
AU  - Heffler, Stephen
AD  - National Health Statistics Group, Office of the Actuary, Centers for Medicare and Medicaid Services, Baltimore, Maryland micah.hartman@cms.hhs.gov
Y1  - 2008///0,
PY  - 2008
DA  - 0, 2008
SP  - w1
EP  - w12
PB  - Project HOPE, Bethesda MD
VL  - 27
IS  - Supplement
SN  - 0278-2715, 0278-2715
KW  - Population groups, population policy, and demographics - Children and youth
KW  - Population groups, population policy, and demographics - Demography and census
KW  - Health conditions and policy - Health and health policy
KW  - Medicare
KW  - Old age
KW  - Health policy
KW  - Adults
KW  - Children
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58774822?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=U.S.+Health+Spending+By+Age%2C+Selected+Years+Through+2004%3A+Recent+trends+indicate+that+per+person+spending+for+the+oldest+elderly+is+growing+more+slowly+than+spending+for+all+other+age+groups&rft.au=Hartman%2C+Micah%3BCatlin%2C+Aaron%3BLassman%2C+David%3BCylus%2C+Jonathan%3BHeffler%2C+Stephen&rft.aulast=Hartman&rft.aufirst=Micah&rft.date=2008-01-01&rft.volume=27&rft.issue=Supplement&rft.spage=w1&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.27.1.w1
LA  - English
DB  - PAIS Index
N1  - Date revised - 2008-08-04
N1  - Last updated - 2016-09-28
N1  - SubjectsTermNotLitGenreText - Health policy; Children; Adults; Old age; Medicare
DO  - http://dx.doi.org/10.1377/hlthaff.27.1.w1
ER  - 



TY  - BOOK
T1  - Guidelines for the Development of a New Miner Training Curriculum
AN  - 58769727; 2008-150286
AB  - This report is intended to help mine safety trainers better prepare to teach the influx of new underground coal miners who are entering the industry. This is done by identifying two different approaches to instruction and discussing the ways they may affect how well prepared new hires are to deal with a dynamic and hazardous workplace. One approach is based on the use of a syllabus. Those using a syllabus are more likely to rely on lecturing or direct instruction. This is a good way to get across factual information, but does not provide a context within which miners can fit the discrete facts so that they form an integrated whole set of concepts, principles, and skills. The other approach is based on the use of a curriculum. Those using a curriculum may be more likely to help miners integrate concepts and skills that give them an overall picture of the complex mining environment and how they fit into the workplace. Tables, Appendixes, References.
JF  - United States National Institute for Occupational Safety and Health (NIOSH), Jan 2008, 30 pp.
AU  - Mallett, Launa G
AU  - Vaught, Charles
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
EP  - 30p
PB  - United States National Institute for Occupational Safety and Health (NIOSH)
KW  - Environment and environmental policy - Mining and mineral resources
KW  - Education and education policy - Curriculum
KW  - Business and service sector - Business operations, practices, and workplaces
KW  - Social conditions and policy - Public safety and security
KW  - Curriculum
KW  - Miners
KW  - Safety measures
KW  - Workplaces
KW  - book
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58769727?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mallett%2C+Launa+G%3BVaught%2C+Charles&rft.aulast=Mallett&rft.aufirst=Launa&rft.date=2008-01-01&rft.volume=&rft.issue=&rft.spage=30p&rft.isbn=&rft.btitle=Guidelines+for+the+Development+of+a+New+Miner+Training+Curriculum&rft.title=Guidelines+for+the+Development+of+a+New+Miner+Training+Curriculum&rft.issn=&rft_id=info:doi/
L2  - http://www.cdc.gov/niosh/mining/pubs/pdfs/2008-105.pdf
LA  - English
DB  - PAIS Index
N1  - Date revised - 2008-06-04
N1  - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008
N1  - SuppNotes - NIOSH Publication No. 2008-105
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - Health Spending Projections through 2017: The Baby-Boom Generation is Coming to Medicare. Accelerating growth in Medicare spending by the end of the projection period is the first sign of the coming demographic shift.
AN  - 58768017; 2008-173726
AB  - The outlook for national health spending calls for continued steady growth. Spending growth is projected to be 6.7 percent in 2007, similar to its rate in 2006. Average annual growth over the projection period is expected to be 6.7 percent. Slower growth in private spending toward the end of the period is expected to be offset by stronger growth in public spending. The health share of gross domestic product (GDP) is expected to increase to 16.3 percent in 2007 & then rise throughout the projection period, reaching 19.5 percent of GDP by 2017. Tables, Graphs. Adapted from the source document.
JF  - Health Affairs
AU  - Keehan, Sean
AU  - Sisko, Andrea
AU  - Truffer, Christopher
AU  - Smith, Sheila
AU  - Cowan, Cathy
AU  - Poisal, John
AU  - Clemens, M Kent
AU  - National Health Expenditure Accounts Projections Team
AD  - NHSG e-mail:DNHS@cms.hhs.gov
Y1  - 2008///0,
PY  - 2008
DA  - 0, 2008
SP  - w145
EP  - w155
PB  - Project HOPE, Bethesda MD
VL  - 27
SN  - 0278-2715, 0278-2715
KW  - Health conditions and policy - Health and health policy
KW  - Economic conditions and policy - Economic conditions
KW  - Medicare
KW  - Health policy
KW  - Economic conditions
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58768017?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Health+Spending+Projections+through+2017%3A+The+Baby-Boom+Generation+is+Coming+to+Medicare.+Accelerating+growth+in+Medicare+spending+by+the+end+of+the+projection+period+is+the+first+sign+of+the+coming+demographic+shift.&rft.au=Keehan%2C+Sean%3BSisko%2C+Andrea%3BTruffer%2C+Christopher%3BSmith%2C+Sheila%3BCowan%2C+Cathy%3BPoisal%2C+John%3BClemens%2C+M+Kent%3BNational+Health+Expenditure+Accounts+Projections+Team&rft.aulast=Keehan&rft.aufirst=Sean&rft.date=2008-01-01&rft.volume=27&rft.issue=&rft.spage=w145&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/
LA  - English
DB  - PAIS Index
N1  - Date revised - 2008-08-04
N1  - Last updated - 2016-09-28
N1  - SubjectsTermNotLitGenreText - Medicare; Health policy; Economic conditions
ER  - 



TY  - JOUR
T1  - National Health Spending In 2006: A Year Of Change For Prescription Drugs
AN  - 58755374; 2008-127806
AB  - In 2006, U.S. health care spending increased 6.7 percent to $.1 trillion, or $7,026 per person. The health care portion of gross domestic product (GDP) was 16.0 percent, slightly higher than in 2005. Prescription drug spending growth accelerated in 2006 to 8.5 percent, partly as a result of Medicare Part D's impact. Most of the other major health care services and public payers experienced slower growth in 2006 than in prior years. The implementation of Medicare Part D caused a major shift in the distribution of payers for prescription drugs, as Medicare played a larger role in drug purchases than it had before. Adapted from the source document.
JF  - Health Affairs
AU  - Catlin, Aaron
AU  - Cowan, Cathy
AU  - Hartman, Micah
AU  - Heffler, Stephen
AD  - National Health Statistics Group, CMS Office, Actuary, Catlin aaron.catlin@cms.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 14
EP  - 29
PB  - Project HOPE, Bethesda MD
VL  - 27
IS  - 1
SN  - 0278-2715, 0278-2715
KW  - Health conditions and policy - Health and health policy
KW  - Business and service sector - Business finance
KW  - Health conditions and policy - Medicine and health care
KW  - Manufacturing and heavy industry - Pharmaceutical industry
KW  - Prescriptions
KW  - Public health administration
KW  - United States
KW  - Finance
KW  - Appropriations and expenditures
KW  - Medicare
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58755374?accountid=14244
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LA  - English
DB  - PAIS Index
N1  - Date revised - 2008-04-02
N1  - Last updated - 2016-09-28
N1  - SubjectsTermNotLitGenreText - United States; Public health administration; Finance; Prescriptions; Medicare; Appropriations and expenditures
DO  - http://dx.doi.org/10.1377/hlthaff.27.1.14
ER  - 



TY  - JOUR
T1  - Laws, leaders, and legends of the modern National Library of Medicine.
AN  - 57708135; 200804798
AB  - Purpose: The paper is an expanded version of the 2007 Joseph Leiter National Library of Medicine (NLM)/Medical Library Association Lecture presented at MLA '07, the Medical Library Association annual meeting in Philadelphia in May 2007. It presents an historical accounting of four major pieces of legislation, beginning with the NLM Act of 1956 up through the creation of the National Center for Biotechnology Information. Brief Description: The transition from the United States Armed Forces Medical Library to the United States National Library of Medicine in 1956 was a major turning point in NLM's history, scope, and direction. The succeeding landmark legislative achievements - namely, the 1965 Medical Library Assistance Act, the 1968 Joint Resolution forming the Lister Hill National Center for Biomedical Communications, and the 1988 authorization for the National Center for Biotechnology Information - transformed the library into a major biomedical communications institution and a leader and supporter of an effective national network of libraries of medicine. The leaders of the library and its major advocates - including Dr. Michael DeBakey, Senator Lister Hill, and Senator Claude Pepper - together contributed to the creation of the modern NLM. Adapted from the source document.
JF  - Journal of the Medical Library Association (JMLA)
AU  - Smith, Kent A
AD  - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894 ksmith@kasenterprise.com
Y1  - 2008///0,
PY  - 2008
DA  - 0, 2008
SP  - 121
EP  - 133
PB  - Medical Library Association, Chicago, IL
VL  - 96
IS  - 2
SN  - 1536-5050, 1536-5050
KW  - National Library of Medicine, USA
KW  - Law
KW  - Library history
KW  - Medical libraries
KW  - article
KW  - 3.19: SCIENCE, TECHNOLOGY, MEDICINE LIBRARIES
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Laws%2C+leaders%2C+and+legends+of+the+modern+National+Library+of+Medicine.&rft.au=Smith%2C+Kent+A&rft.aulast=Smith&rft.aufirst=Kent&rft.date=2008-01-01&rft.volume=96&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.96.2.121
L2  - http://www.mlanet.org/publications/jmla/
LA  - English
DB  - Library & Information Science Abstracts (LISA)
N1  - Date revised - 2008-08-04
N1  - Last updated - 2016-09-27
N1  - SubjectsTermNotLitGenreText - Medical libraries; Library history; Law; National Library of Medicine, USA
DO  - http://dx.doi.org/10.3163/1536-5050.96.2.121
ER  - 



TY  - JOUR
T1  - A Concept Analysis: Adherence and Weight Loss
AN  - 57299521; 200916884
AB  - There are numerous factors that influence an individual's ability to adhere to a healthy behavior. The literature cites common events that must take place prior to maintaining an exercise plan, a medication regimen, and a healthy diet. The purpose of this paper is to examine the concept of adherence in relation to weight loss using Walker and Avant's (1995) framework for concept analysis. This analysis revealed an extensive list of events or antecedents that may prove to be important when considering new strategies for weight management. Adapted from the source document.
JF  - Nursing Forum
AU  - Shay, Laura E
AD  - Uniformed Services University, Bethesda, MD laura.shay@fda.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 42
EP  - 52
PB  - Wiley-Blackwell, UK
VL  - 43
IS  - 1
SN  - 0029-6473, 0029-6473
KW  - Healthy habits
KW  - Concept analysis
KW  - Adherence
KW  - Weight loss
KW  - Exercise
KW  - Diet
KW  - article
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Forum&rft.atitle=A+Concept+Analysis%3A+Adherence+and+Weight+Loss&rft.au=Shay%2C+Laura+E&rft.aulast=Shay&rft.aufirst=Laura&rft.date=2008-01-01&rft.volume=43&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Nursing+Forum&rft.issn=00296473&rft_id=info:doi/10.1111%2Fj.1744-6198.2008.00095.x
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2009-07-06
N1  - Last updated - 2016-09-27
N1  - SubjectsTermNotLitGenreText - Weight loss; Adherence; Concept analysis; Diet; Exercise; Healthy habits
DO  - http://dx.doi.org/10.1111/j.1744-6198.2008.00095.x
ER  - 



TY  - JOUR
T1  - Perspective: Eyes on the prize: Federal Alzheimer's research effort aims to facilitate interventions
AN  - 57290372; 200915133
AB  - The public Alzheimer's disease (AD) research enterprise began in earnest in the mid-1970s with the creation by Congress of the National Institute on Aging at the National Institutes of Health. Today, AD research is a maturing field of study, with federal effort seeking to encourage the creativity and insights of individual investigators, and targeting special areas for emphasis. It is inspired by the legacy of our friend and colleague Leon Thal, whose innovative and collaborative approach to scientific research serves as a guidepost as we move toward the discovery of new and effective ways to prevent AD or slow its progression. This article describes the progress to date and potentially promising areas of study from the vantage point of the National Institute on Aging. [Copyright Elsevier B.V.]
JF  - Alzheimer's & Dementia
AU  - Hodes, Richard J
AU  - Buckholtz, Neil
AU  - Cahan, Vicky
AU  - Morrison-Bogorad, Marcelle
AD  - National Institute on Aging, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - S37
EP  - S47
PB  - Elsevier Ltd, The Netherlands
VL  - 4
IS  - 1S1
SN  - 1552-5260, 1552-5260
KW  - Alzheimer's disease National Institute on Aging Dementia
KW  - Ageing
KW  - Congress
KW  - Alzheimer's disease
KW  - Creativity
KW  - Enterprises
KW  - Eyes
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57290372?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alzheimer%27s+%26+Dementia&rft.atitle=Perspective%3A+Eyes+on+the+prize%3A+Federal+Alzheimer%27s+research+effort+aims+to+facilitate+interventions&rft.au=Hodes%2C+Richard+J%3BBuckholtz%2C+Neil%3BCahan%2C+Vicky%3BMorrison-Bogorad%2C+Marcelle&rft.aulast=Hodes&rft.aufirst=Richard&rft.date=2008-01-01&rft.volume=4&rft.issue=1S1&rft.spage=S37&rft.isbn=&rft.btitle=&rft.title=Alzheimer%27s+%26+Dementia&rft.issn=15525260&rft_id=info:doi/10.1016%2Fj.jalz.2007.11.002
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2009-07-06
N1  - Last updated - 2016-09-27
N1  - SubjectsTermNotLitGenreText - Alzheimer's disease; Ageing; Enterprises; Congress; Eyes; Creativity
DO  - http://dx.doi.org/10.1016/j.jalz.2007.11.002
ER  - 



TY  - JOUR
T1  - Depression in Public Community Long-Term Care: Implications for Intervention Development
AN  - 57274785; 200916114
AB  - The objective of this paper is to increase understanding of geriatric depression in the public community long-term care system to guide intervention development. Protocols included screening 1,170 new clients of a public community long-term care agency and interviewing all clients with major, dysthymia, or subthreshold depression (n=299) and a randomly selected subset of nondepressed older adults (n=315) at baseline, 6-month, and 1 year. Six percent had major depression, one-half of a percent had dysthymia only, and another 19% had subthreshold depression. Over the year observation period, 40% were persistently depressed; 32% were assessed as depressed only at the first observation; and the remainder was intermittently depressed. There were high levels of comorbid medical, functional, and psychosocial conditions. Mental health service use was low, and clients reported attitudinal and other barriers to depression treatment. Findings suggest the need for universal screening for depression with some strategies for triaging the most severely and persistently depressed for treatment. Although there will be challenges to the development of depression interventions, the public community long-term care system has high potential to assist vulnerable older adults receive help with depression. Adapted from the source document.
JF  - The Journal of Behavioral Health Services & Research
AU  - Morrow-Howell, Nancy
AU  - Proctor, Enola
AU  - Choi, Sunha
AU  - Lawrence, Lisa
AU  - Brooks, Ashley
AU  - Hasche, Leslie
AU  - Dore, Peter
AU  - Blinne, Wayne
AD  - Center for Mental Health Services Research, Washington University, Campus Box 1196, St. Louis, MO 63130, USA morrow-howell@wustl.edu
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 37
EP  - 51
PB  - Lippincott Williams & Wilkins, Philadelphia PA
VL  - 35
IS  - 1
SN  - 1094-3412, 1094-3412
KW  - Screening
KW  - Elderly people
KW  - Depression
KW  - Long term care
KW  - Comorbidity
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57274785?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Depression+in+Public+Community+Long-Term+Care%3A+Implications+for+Intervention+Development&rft.au=Morrow-Howell%2C+Nancy%3BProctor%2C+Enola%3BChoi%2C+Sunha%3BLawrence%2C+Lisa%3BBrooks%2C+Ashley%3BHasche%2C+Leslie%3BDore%2C+Peter%3BBlinne%2C+Wayne&rft.aulast=Morrow-Howell&rft.aufirst=Nancy&rft.date=2008-01-01&rft.volume=35&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-007-9098-7
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2009-07-06
N1  - Last updated - 2016-09-27
N1  - SubjectsTermNotLitGenreText - Depression; Long term care; Elderly people; Screening; Comorbidity
DO  - http://dx.doi.org/10.1007/s11414-007-9098-7
ER  - 



TY  - JOUR
T1  - Policy and practice implications of epidemiological surveys on co-occurring mental and substance use disorders
AN  - 57259587; 200813506
AB  - This article describes factors that influence national policy and practice, with particular focus on the implications of epidemiological survey research. Examples of areas of concern to policymakers include treatment-seeking patterns, access to care at points of service in public health and social service systems, evidence-based practices, workforce development, and the complexities of reimbursement. In responding to data on systemic barriers to care, the Substance Abuse and Mental Health Services Administration (SAMHSA) has sought to promote a no wrong door strategy to address the needs of persons with co-occurring disorders (CODs) involving their mental health and substance use. Examples of SAMHSA programs and policies addressing CODs discussed in this article include targeted partnerships with the states, mechanisms to enhance system infrastructure, technical assistance, and initiatives with special populations. [Copyright 2006 Elsevier Inc.]
JF  - Journal of Substance Abuse Treatment
AU  - Clark, H Westley
AU  - Power, A Kathryn
AU  - Le Fauve, Charlene E
AU  - Lopez, Elizabeth I
AD  - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, MD westley.clark@samhsa.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 3
EP  - 13
PB  - Elsevier, New York NY
VL  - 34
IS  - 1
SN  - 0740-5472, 0740-5472
KW  - Co-occurring disorders
KW  - SAMHSA
KW  - Epidemiology
KW  - NSDUH
KW  - Policy
KW  - Substance abuse disorders
KW  - Psychiatric disorders
KW  - Policy making
KW  - Comorbidity
KW  - Evidence based medicine
KW  - Helpseeking
KW  - article
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LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-06-27
N1  - Last updated - 2016-09-27
N1  - CODEN - JSATEG
N1  - SubjectsTermNotLitGenreText - Substance abuse disorders; Comorbidity; Psychiatric disorders; Helpseeking; Evidence based medicine; Policy making
DO  - http://dx.doi.org/10.1016/j.jsat.2006.12.032
ER  - 



TY  - JOUR
T1  - The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of new psychiatric diagnostic modules and risk factors in a general population sample
AN  - 57229447; 200812587
AB  - This study presents test-retest reliability statistics and information on internal consistency for new diagnostic modules and risk factors for alcohol, drug, and psychiatric disorders from the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV). Test-retest statistics were derived from a random sample of 1899 adults selected from 34,653 respondents who participated in the 2004-2005 Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Internal consistency of continuous scales was assessed using the entire Wave 2 NESARC. Both test and retest interviews were conducted face-to-face. Test-retest and internal consistency results for diagnoses and symptom scales associated with posttraumatic stress disorder, attention-deficit/hyperactivity disorder, and borderline, narcissistic, and schizotypal personality disorders were predominantly good (kappa>0.63; ICC>0.69; alpha>0.75) and reliability for risk factor measures fell within the good to excellent range (intraclass correlations=0.50-0.94; alpha=0.64-0.90). The high degree of reliability found in this study suggests that new AUDADIS-IV diagnostic measures can be useful tools in research settings. The availability of highly reliable measures of risk factors for alcohol, drug, and psychiatric disorders will contribute to the validity of conclusions drawn from future research in the domains of substance use disorder and psychiatric epidemiology. [Copyright 2007 Elsevier Ireland Ltd.]
JF  - Drug and Alcohol Dependence
AU  - Ruan, W June
AU  - Goldstein, Rise B
AU  - Chou, S Patricia
AU  - Smith, Sharon M
AU  - Saha, Tulshi D
AU  - Pickering, Roger P
AU  - Dawson, Deborah A
AU  - Huang, Boji
AU  - Stinson, Frederick S
AU  - Grant, Bridget F
AD  - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, United States
Y1  - 2008/01/01/
PY  - 2008
DA  - 2008 Jan 01
SP  - 27
EP  - 36
PB  - Elsevier Ireland, Amsterdam The Netherlands
VL  - 92
IS  - 1-3
SN  - 0376-8716, 0376-8716
KW  - Reliability
KW  - Alcohol and drug use disorders
KW  - Risk factors
KW  - Test-retest reliability
KW  - General population
KW  - Internal consistency
KW  - Diagnostic testing
KW  - Test-Retest reliability
KW  - Psychiatric disorders
KW  - Alcohol related disorders
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57229447?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=The+Alcohol+Use+Disorder+and+Associated+Disabilities+Interview+Schedule-IV+%28AUDADIS-IV%29%3A+Reliability+of+new+psychiatric+diagnostic+modules+and+risk+factors+in+a+general+population+sample&rft.au=Ruan%2C+W+June%3BGoldstein%2C+Rise+B%3BChou%2C+S+Patricia%3BSmith%2C+Sharon+M%3BSaha%2C+Tulshi+D%3BPickering%2C+Roger+P%3BDawson%2C+Deborah+A%3BHuang%2C+Boji%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Ruan&rft.aufirst=W&rft.date=2008-01-01&rft.volume=92&rft.issue=1-3&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.06.001
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-06-11
N1  - Last updated - 2016-09-27
N1  - CODEN - DADEDV
N1  - SubjectsTermNotLitGenreText - Diagnostic testing; Reliability; Psychiatric disorders; Alcohol related disorders; Risk factors; Test-Retest reliability
DO  - http://dx.doi.org/10.1016/j.drugalcdep.2007.06.001
ER  - 



TY  - JOUR
T1  - Reinforcing coal mine roof with polyurethane injection; 4 case studies
AN  - 50539003; 2009-006474
JF  - Geotechnical and Geological Engineering
AU  - Molinda, Gregory
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 553
EP  - 566
PB  - Springer, Dordrecht
VL  - 26
IS  - 5
SN  - 0960-3182, 0960-3182
KW  - United States
KW  - mining
KW  - mines
KW  - underground mining
KW  - roof control
KW  - video methods
KW  - reinforced materials
KW  - rock mechanics
KW  - case studies
KW  - sedimentary rocks
KW  - mining geology
KW  - coal
KW  - West Virginia
KW  - 30:Engineering geology
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L2  - http://www.springerlink.com/app/home/journal.asp?wasp=f656ca91cf3b40e8868983de406060e5&referrer=parent&backto=linkingpublicationresults,1:100171,1
LA  - English
DB  - GeoRef
N1  - Copyright - GeoRef, Copyright 2012, American Geosciences Institute.
N1  - Date revised - 2009-01-01
N1  - Number of references - 8
N1  - Document feature - illus. incl. 1 table
N1  - Last updated - 2012-06-07
N1  - SubjectsTermNotLitGenreText - case studies; coal; mines; mining; mining geology; reinforced materials; rock mechanics; roof control; sedimentary rocks; underground mining; United States; video methods; West Virginia
DO  - http://dx.doi.org/10.1007/s10706-008-9189-0
ER  - 



TY  - JOUR
T1  - Projecting long term medical spending growth
AN  - 36794457; 3491073
AB  - We present a dynamic general equilibrium model of the U.S. economy and the medical sector in which the adoption of new medical treatments is endogenous and the demand for medical services is conditional on the state of technology. We use this model to prepare 75-year medical spending forecasts and a projection of the Medicare actuarial balance, and we compare our results to those obtained from a method that has been used by government actuaries. Our baseline forecast predicts slower health spending growth in the long run and a lower Medicare actuarial deficit relative to the previous projection methodology. All rights reserved, Elsevier
JF  - Journal of health economics
AU  - Borger, C
AU  - Rutherford, T F
AU  - Won, Gregory Y
AD  - US Department of Health and Human Services
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 69
EP  - 88
VL  - 27
IS  - 1
SN  - 0167-6296, 0167-6296
KW  - Economics
KW  - Medicare
KW  - Medical care
KW  - Public expenditure
KW  - Economic forecasts
KW  - Health policy
KW  - General economic equilibrium
KW  - U.S.A.
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LA  - English
DB  - International Bibliography of the Social Sciences (IBSS)
N1  - Date revised - 2013-06-12
N1  - Last updated - 2013-09-16
N1  - SubjectsTermNotLitGenreText - 3937 5163; 5788 11888 10472; 5436 4375; 7875 5775 13521; 10443 4618; 433 293 14
DO  - http://dx.doi.org/10.1016/j.jhealeco.2007.03.003
ER  - 



TY  - JOUR
T1  - Emerging Enteric and Potentially Waterborne Pathogens
AN  - 21241382; 11188379
AB  - Infectious water-borne pathogens are a major cause of morbidity and mortality. A substantial proportion of water-borne disease is caused by established pathogens. However, emerging pathogens present important challenges to the water and health sectors. The last 30 to 40 years has seen the initial identification of a number of significant pathogens that can be water-borne including rotavirus, norovirus, V.cholerae 0139, Cryptosporidium, Campylobacter and Legionella. Many more are classified as emerging due to detection of increased incidence of disease or detection in areas where they were not previously established. The emergence of infectious diseases, including those that are water-borne, is caused by a number of factors such as population growth, migration, travel, new environments, climate change, improved methodology and drug resistance. Understanding these factors is an important component of establishing effective management of water resources and drinking water safety plans.
JF  - Water Practice and Technology
AU  - Cunliffe, DA
AD  - Public Health Service, Department of Health, PO Box 6, Rundle Mall, South Australia 5001, david.cunime@health.sa.gov.au
Y1  - 2008
PY  - 2008
DA  - 2008
VL  - 3
IS  - 4
KW  - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Aqualine Abstracts; Water Resources Abstracts
KW  - Rotavirus
KW  - Travel
KW  - Population growth
KW  - Drug resistance
KW  - Viruses
KW  - Climatic changes
KW  - Water resources
KW  - Migration
KW  - Morbidity
KW  - Drinking Water
KW  - Infectious diseases
KW  - Water-borne diseases
KW  - Climatic Changes
KW  - Diseases
KW  - Legionella
KW  - Mortality
KW  - Campylobacter
KW  - Norovirus
KW  - Pathogens
KW  - Cryptosporidium
KW  - Drinking water
KW  - AQ 00001:Water Resources and Supplies
KW  - V 22300:Methods
KW  - SW 0810:General
KW  - J 02320:Cell Biology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-02-01
N1  - Last updated - 2015-03-31
N1  - SubjectsTermNotLitGenreText - Travel; Mortality; Infectious diseases; Drug resistance; Population growth; Climatic changes; Water-borne diseases; Water resources; Pathogens; Drinking water; Migration; Morbidity; Drinking Water; Viruses; Cryptosporidium; Climatic Changes; Diseases; Rotavirus; Campylobacter; Norovirus; Legionella
DO  - http://dx.doi.org/10.2166/wpt.2008.092
ER  - 



TY  - BOOK
T1  - Effects of Microbiota on GI Health: Gnotobiotic Research
AN  - 21239439; 11277202
AB  - The complex interactions between the GI tract microbiota and the immune system can be simplified for study using gnotobiotic animal models. The importance of cytokines, such as IFN-*g, TNF-*a, TGF-*b, Interleukin-2, IL-4 and IL-10 in the host response to intestinal bacteria has been evaluated using gnotobiotic studies. Gnotobiotic experiments with immunodeficient animals have revealed insights into the relationships between innate, cell-mediated and antibody-mediated immune system components in resistance to infectious microorganisms. The development and maturation of the immune system is dependent on the presence of some members of the intestinal microbiota. The commensal microorganisms, in turn, are dependent on the environment and nutrients provided by the GI tract of the host. Gnotobiotic studies are starting to reveal how the microbiota influences oral tolerance to dietary and commensal bacterial antigens. The immunomodulatory effects of microbiota and probiotics for inflammatory bowel diseases and the role of bacteria in their etiologies are being studied in gnotobiotic systems. Many aspects of the host interaction with the microbiota have been and will continue to be best addressed in gnotobiotic experimental models. This chapter reviews the contributions that gnotobiology has made to our understanding of the microbiota and host GI tract health.
JF  - Advances in Experimental Medicine and Biology
AU  - Wagner, Robert Doug
A2  - Huffnagle, Gary B
A2  - Noverr, Mairi C (Eds)
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 16
EP  - 56
PB  - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany
SN  - 9780387799896
KW  - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts
KW  - Interleukin 4
KW  - Etiology
KW  - Interleukin 2
KW  - Immune system
KW  - Immunodeficiency
KW  - Animal models
KW  - probiotics
KW  - Commensals
KW  - Nutrients
KW  - Immunomodulation
KW  - Immunological tolerance
KW  - Interleukin 10
KW  - Oral cavity
KW  - Intestinal microflora
KW  - Inflammatory bowel diseases
KW  - Microorganisms
KW  - Gnotobiotics
KW  - Intestine
KW  - Gastrointestinal tract
KW  - A 01330:Food Microbiology
KW  - J 02350:Immunology
KW  - F 06930:Autoimmunity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-02-01
N1  - Last updated - 2015-03-31
DO  - http://dx.doi.org/10.1007/978-0-387-09550-9
ER  - 



TY  - JOUR
T1  - Heteroresistance to vancomycin and novel point mutations in Tn1546 of Enterococcus faecium ATCC 51559
AN  - 21043404; 8580666
AB  - A clinical strain of Enterococcus faecium ATCC 51559 exhibits heteroresistance, i.e. a high level of resistance to vancomycin (minimum inhibitory concentration (MIC) > 256 kg/mL) by broth dilution but sensitivity to vancomycin by Etest (MIC = 1.8 kg/mL). Three variants of this strain, EF1, EF2 and EF3, exhibit high levels of resistance to vancomycin both by broth dilution and Etest assays. The four strains were used to study heteroresistance by pulsed-field gel electrophoresis (PFGE), polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) and sequence analysis of a partial region of the van operon. Minor differences between SalI and SmaI restriction profiles of the variants and the parental strain were observed by PFGE analysis. PCR analysis confirmed the presence of the vancomycin resistance marker vanA (0.73 kb) and a larger than expected amplicon (8.2 kb vs. 6.7 kb) of the van operon in all the strains. The 8.2 kb van operon was cloned for EcoRI RFLP and sequence analysis. All of the clones exhibited distinctly different RFLP profiles when grown in the presence of kanamycin or vancomycin + kanamycin. The presence of these antibiotics during overnight growth of EF1 on plates also resulted in altered SalI PFGE profiles. Sequence analysis of the van operon clones revealed a 1.5 kb IS1251-like insertion element between the vanS and vanH genes in all the strains. Several novel point mutations in the vanR, vanS, vanH, vanA, vanX and vanY genes were also discovered. Some of these mutations were present in the parental strain only and included base substitutions T --> C, A --> G, T --> A and T - -> C at nucleotide positions 4202, 4597, 4763 and 6207 of Tn1546, resulting in amino acid replacements I76 --> T and K208 --> E of vanR, S19 --> T of vanS and L64 --> P of vanH genes, respectively. We believe that these are responsible for the observed heteroresistance. The present study clearly shows how independent novel mutations can give rise to polymorphism, heteroresistance and clonal diversity among vancomycin- resistant enterococci strains as a result of continuous exposure to antibiotics.
JF  - International Journal of Antimicrobial Agents
AU  - Khan, Saeed A
AU  - Sung, Kidon
AU  - Layton, Sherryll
AU  - Nawaz, Mohamed S
AD  - Division of Microbiology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA, saeed.khan@fda.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 27
EP  - 36
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 31
IS  - 1
SN  - 0924-8579, 0924-8579
KW  - Microbiology Abstracts B: Bacteriology
KW  - Vancomycin-resistant enterococci
KW  - Polymerase chain reaction
KW  - Restriction fragment length polymorphism
KW  - Pulsed-field gel electrophoresis
KW  - Insertion element
KW  - Amino acids
KW  - Amino acid substitution
KW  - Point mutation
KW  - Antibiotics
KW  - Kanamycin
KW  - Minimum inhibitory concentration
KW  - Nucleotides
KW  - Enterococcus faecium
KW  - Vancomycin
KW  - Operons
KW  - J 02340:Antibiotics & Antimicrobials
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-11-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Amino acid substitution; Amino acids; Point mutation; Pulsed-field gel electrophoresis; Restriction fragment length polymorphism; Polymerase chain reaction; Vancomycin; Kanamycin; Antibiotics; Operons; Minimum inhibitory concentration; Nucleotides; Enterococcus faecium
DO  - http://dx.doi.org/10.1016/j.ijantimicag.2007.08.007
ER  - 



TY  - JOUR
T1  - Application of Prevention through Design for Hearing Loss in the Mining Industry
AN  - 21034036; 8549653
AB  - Introduction Overexposure to noise remains a widespread and serious health hazard in the U.S. service providing and goods producing industries. Excessive noise can lead to poor verbal communication and reduce the ability to recognize warning signals. These dangerous work conditions can also cause stress and fatigue. Occupational hearing loss is a permanent illness, with no recovery currently possible. Method National Institute for Occupational Safety and Health (NIOSH) has recognized Noise Induced Hearing Loss (NIHL) as one of the ten leading work-related diseases and injuries in the United States, and has emphasized its importance as one of the critical areas expressed in the National Occupational Research Agenda. Results One of the most serious noise problems in the goods producing industries is the operation of continuous mining machines during underground coal mining. In order to minimize occupational hearing loss, noise hazards are 'designed out' early in the design process. NIOSH is leading a national initiative called Prevention through Design (PTD) to promote this concept. This paper describes the quiet-by-design approach of a noise control that reduced noise exposures of continuous mining machine operators by 3dB(A) using the four functional areas of PTD, namely Practice, Policy, Research, and Education.
JF  - Journal of Safety Research
AU  - Kovalchik, Peter G
AU  - Matetic, Rudy J
AU  - Smith, Adam K
AU  - Bealko, Susan B
AD  - National Institute for Occupational Safety and Health, PKovalchik@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 251
EP  - 254
PB  - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl]
VL  - 39
IS  - 2
SN  - 0022-4375, 0022-4375
KW  - Health & Safety Science Abstracts
KW  - Occupational safety
KW  - Noise reduction
KW  - Coal
KW  - fatigue
KW  - prevention
KW  - policy research
KW  - Noise levels
KW  - Stress
KW  - Hearing loss
KW  - Design
KW  - Education
KW  - USA
KW  - Communications
KW  - Mining
KW  - H 1000:Occupational Safety and Health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-11-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - USA; Noise levels; Hearing loss; Mining; Noise reduction; prevention; Communications; Design; Coal; Education; Stress; Occupational safety; policy research; fatigue
DO  - http://dx.doi.org/10.1016/j.jsr.2008.02.029
ER  - 



TY  - JOUR
T1  - Problems of groundwater management and the need for its inclusion in the Brazilian national model of integrated water resources management
AN  - 21021577; 8190738
AB  - This paper discusses certain issues related to groundwater management within the context of the Brazilian national policy for water resources management. In order to investigate the importance of this water supply source, we interviewed groundwater users in the city of Sao Paulo, where some 57% of the total water supply comes from this source, and surveyed some of the factors affecting the use of this alternative. These include the existence of a good supply of groundwater, an inadequate public water supply system unable to meet user demands, the degradation of fresh water sources and the reduction in costs involved. Preliminary conclusions suggest the inadequacy of the present system of water resources management, which has not yet integrated the use of groundwater reserves into an overall national program for water resources management.
JF  - Water Policy
AU  - Rodrigues, FdA
AU  - Pereira, SY
AD  - Department of Geology and Natural Resources, State University of Campinas, 51 Pandia Calogeras, Campinas, SP, P.A. 13083 - 970, Brazil, assis@ige.unicamp.br
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 165
EP  - 171
VL  - 10
IS  - 2
SN  - 1366-7017, 1366-7017
KW  - Pollution Abstracts; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts
KW  - Degradation
KW  - Water Costs
KW  - Groundwater management
KW  - Water Supply
KW  - Water resources
KW  - Public Waters
KW  - Water Resources Management
KW  - Water supplies
KW  - Potential resources
KW  - Water Policy
KW  - Ground water
KW  - Water sources
KW  - Groundwater Management
KW  - Urban areas
KW  - Modelling
KW  - water policy
KW  - Water resources management
KW  - Policies
KW  - Model Studies
KW  - Water supply
KW  - Brazil, Sao Paulo
KW  - Water management
KW  - Groundwater
KW  - Water policy
KW  - Q2 09122:Legislation
KW  - P 2000:FRESHWATER POLLUTION
KW  - M3 1010:Issues in Sustainable Development
KW  - M2 556.18:Water Management (556.18)
KW  - SW 3020:Sources and fate of pollution
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-01
N1  - Last updated - 2014-05-07
N1  - SubjectsTermNotLitGenreText - Policies; Potential resources; Water management; Ground water; Water resources; Modelling; Water policy; Water supply; Water resources management; Groundwater management; Water sources; water policy; Degradation; Groundwater; Water supplies; Urban areas; Water Policy; Water Costs; Water Supply; Public Waters; Water Resources Management; Groundwater Management; Model Studies; Brazil, Sao Paulo
DO  - http://dx.doi.org/10.2166/wp.2008.038
ER  - 



TY  - JOUR
T1  - Reducing Commercial Fishing Deck Hazards with Engineering Solutions for Winch Design
AN  - 21020455; 8549651
AB  - Introduction The majority (67%) of hospitalized injuries among Alaska commercial fishermen are associated with deck machinery. This paper describes the 'Prevention Through Design' process to mitigate one serious machinery entanglement hazard posed by a capstan deck winch. Methods After observing that the capstan winch provides no entanglement protection and the hydraulic controls are usually out of reach of the entangled person, NIOSH personnel met with fishermen and winch manufacturers to discuss various design solutions to mitigate these hazards. Results An emergency-stop ('e-stop') system was developed that incorporated a momentary contact button that when pushed, switches a safety-relay that de-energizes the solenoid of an electro-hydraulic valve stopping the rotating winch. The vessel owners that had the e-stop installed enthusiastically recommend it to other fishermen. NIOSH entered into a Proprietary Technology Licensing Agreement with a company to develop the system for commercial use. Conclusions This is an example of a practical engineering control that effectively protects workers from a hazardous piece of equipment by preventing injuries due to entanglement. This solution could reduce these types of debilitating injuries and fatalities in this industry.
JF  - Journal of Safety Research
AU  - Lincoln, Jennifer M
AU  - Lucas, Devin L
AU  - McKibbin, Robert W
AU  - Woodward, Chelsea C
AU  - Bevan, John E
AD  - NIOSH Alaska Field Station, Anchorage Alaska, jlincoln@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 231
EP  - 235
PB  - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl]
VL  - 39
IS  - 2
SN  - 0022-4375, 0022-4375
KW  - Health & Safety Science Abstracts
KW  - Hydraulics
KW  - Injuries
KW  - Occupational safety
KW  - Licensing
KW  - Hazards
KW  - Commercial fishing
KW  - Machinery
KW  - prevention
KW  - USA, Alaska
KW  - Mortality
KW  - Design
KW  - safety engineering
KW  - Technology
KW  - H 1000:Occupational Safety and Health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21020455?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Reducing+Commercial+Fishing+Deck+Hazards+with+Engineering+Solutions+for+Winch+Design&rft.au=Lincoln%2C+Jennifer+M%3BLucas%2C+Devin+L%3BMcKibbin%2C+Robert+W%3BWoodward%2C+Chelsea+C%3BBevan%2C+John+E&rft.aulast=Lincoln&rft.aufirst=Jennifer&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.027
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-11-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - USA, Alaska; Injuries; Machinery; safety engineering; Design; Licensing; Mortality; Commercial fishing; Hydraulics; prevention; Technology; Occupational safety; Hazards
DO  - http://dx.doi.org/10.1016/j.jsr.2008.02.027
ER  - 



TY  - JOUR
T1  - McCune-Albright syndrome
AN  - 20999332; 8819346
AB  - McCune-Albright syndrome (MAS) is classically defined by the clinical triad of fibrous dysplasia of bone (FD), cafe-au-lait skin spots, and precocious puberty (PP). It is a rare disease with estimated prevalence between 1/100,000 and 1/1,000,000. FD can involve a single or multiple skeletal sites and presents with a limp and/or pain, and, occasionally, a pathologic fracture. Scoliosis is common and may be progressive. In addition to PP (vaginal bleeding or spotting and development of breast tissue in girls, testicular and penile enlargement and precocious sexual behavior in boys), other hyperfunctioning endocrinopathies may be involved including hyperthyroidism, growth hormone excess, Cushing syndrome, and renal phosphate wasting. Cafe-au-lait spots usually appear in the neonatal period, but it is most often PP or FD that brings the child to medical attention. Renal involvement is seen in approximately 50% of the patients with MAS. The disease results from somatic mutations of the GNAS gene, specifically mutations in the cAMP regulating protein, G sub(s )alpha. The extent of the disease is determined by the proliferation, migration and survival of the cell in which the mutation spontaneously occurs during embryonic development. Diagnosis of MAS is usually established on clinical grounds. Plain radiographs are often sufficient to make the diagnosis of FD and biopsy of FD lesions can confirm the diagnosis. The evaluation of patients with MAS should be guided by knowledge of the spectrum of tissues that may be involved, with specific testing for each. Genetic testing is possible, but is not routinely available. Genetic counseling, however, should be offered. Differential diagnoses include neurofibromatosis, osteofibrous dysplasia, non-ossifying fibromas, idiopathic central precocious puberty, and ovarian neoplasm. Treatment is dictated by the tissues affected, and the extent to which they are affected. Generally, some form of surgical intervention is recommended. Bisphosphonates are frequently used in the treatment of FD. Strengthening exercises are recommended to help maintaining the musculature around the FD bone and minimize the risk for fracture. Treatment of all endocrinopathies is required. Malignancies associated with MAS are distinctly rare occurrences. Malignant transformation of FD lesions occurs in probably less than 1% of the cases of MAS.
JF  - Orphanet Journal of Rare Diseases
AU  - Dumitrescu, Claudia E
AU  - Collins, Michael T
AD  - Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, mosteanuc@nidcr.nih.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 12
PB  - BioMed Central Ltd., Middlesex House
VL  - 3
SN  - 1750-1172, 1750-1172
KW  - Risk Abstracts
KW  - sexual behavior
KW  - pain
KW  - Hormones
KW  - surgery
KW  - risk reduction
KW  - genetic screening
KW  - intervention
KW  - enlargement
KW  - Lesions
KW  - plains
KW  - migration
KW  - Skin
KW  - Bone
KW  - Phosphates
KW  - Proteins
KW  - Neonates
KW  - survival
KW  - Mutation
KW  - bisphosphonates
KW  - R2 23060:Medical and environmental health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20999332?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Orphanet+Journal+of+Rare+Diseases&rft.atitle=McCune-Albright+syndrome&rft.au=Dumitrescu%2C+Claudia+E%3BCollins%2C+Michael+T&rft.aulast=Dumitrescu&rft.aufirst=Claudia&rft.date=2008-01-01&rft.volume=3&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Orphanet+Journal+of+Rare+Diseases&rft.issn=17501172&rft_id=info:doi/10.1186%2F1750-1172-3-12
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-11-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Mutation; genetic screening; Bone; Lesions; sexual behavior; Phosphates; risk reduction; Hormones; enlargement; intervention; bisphosphonates; surgery; pain; survival; migration; Proteins; plains; Skin; Neonates
DO  - http://dx.doi.org/10.1186/1750-1172-3-12
ER  - 



TY  - JOUR
T1  - Effects of Stratification on Data Mining in the US Vaccine Adverse Event Reporting System (VAERS)
AN  - 20978856; 8540473
AB  - Background: Vaccines are administered differentially according to age and sex, and disease patterns also vary among people of different age and sex groups. Estimates of disproportionality should be calculated based on comparisons of groups that have a similar likelihood of receiving similar vaccines and experiencing similar adverse events, to prevent false disproportionality from occurring. Stratified empirical Bayesian (EB) methods have been compared with crude, but not stratified, proportional reporting ratios (PRRs) in their performance on adverse event data. Objectives: (i) to implement stratification of PRR; (ii) to quantify and compare vaccine-event pairs that are highlighted by PRR and EB05 (the lower bound of the 90% CI of the EB geometric mean), for both crude and stratified; and (iii) to evaluate the effects of stratification by age and sex, in identifying adverse events that are accepted to be caused by vaccines. Methods: We applied EB and PRR data mining methods to data from the US Vaccine Adverse Event Reporting System (VAERS). We stratified PRR and EB05 by age and sex. To study the effects of stratification, we compared the crude PRR and stratified PRR. We also assessed the crude EB05 and stratified EB05, and then compared the effects of stratification on EB05 and PRR. Results: Stratification not only changed the number of vaccine-event pairs that were highlighted, but also changed which pairs were highlighted. There were 283 vaccine-event pairs that were highlighted by the crude EB05, but not the stratified; 12 that were highlighted by the stratified EB05, but not the crude; and 162 that were highlighted by both. Similarly, there were 701 vaccine-event pairs that were highlighted by the crude PRR, but not the stratified; 139 that were highlighted by the stratified PRR, but not the crude; and 895 that were highlighted by both. There were 1466 vaccine-event pairs in which the effect of stratification was different for EB05 and PRR. Conclusion: To our knowledge, this is the first published analysis using stratified PRRs. In this analysis of passive surveillance data, stratification revealed and reduced confounding in EB and PRR, and also unmasked some vaccine-event pairs that the crude values did not highlight. Stratification should be applied if confounding is suspected. By decreasing the total number of highlighted vaccine-event pairs, stratification is likely to increase efficiency and therefore might reduce workload.
JF  - Drug Safety
AU  - Emily Jane Woo,
AU  - Ball, Robert
AU  - Burwen, Dale R
AU  - Braun, MMiles
AD  - US Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, Maryland, USA
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 667
EP  - 674
PB  - Adis International Inc., [URL:http://www.adis.com]
VL  - 31
IS  - 8
SN  - 0114-5916, 0114-5916
KW  - Health & Safety Science Abstracts
KW  - Adverse drug reactions
KW  - Adverse reaction monitoring
KW  - Data collection
KW  - Postmarketing surveillance
KW  - Vaccines
KW  - age groups
KW  - USA
KW  - vaccines
KW  - Age
KW  - Stratification
KW  - Drugs
KW  - Side effects
KW  - working conditions
KW  - H 4000:Food and Drugs
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20978856?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Safety&rft.atitle=Effects+of+Stratification+on+Data+Mining+in+the+US+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29&rft.au=Emily+Jane+Woo%2C%3BBall%2C+Robert%3BBurwen%2C+Dale+R%3BBraun%2C+MMiles&rft.aulast=Emily+Jane+Woo&rft.aufirst=&rft.date=2008-01-01&rft.volume=31&rft.issue=8&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Drug+Safety&rft.issn=01145916&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-10-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - age groups; Age; Data collection; vaccines; Stratification; Drugs; working conditions; Side effects; USA
ER  - 



TY  - JOUR
T1  - Intervention Effectiveness Evaluation Criteria: Promoting Competitions and Raising the Bar
AN  - 20978282; 8549422
AB  - The Intervention Evaluation Competition at the Work, Stress, and Health conference in Miami (March 2006) highlighted the importance of intervention evaluation studies that promote safety and health at work. A retitled, 'Best Practices Evaluation Competition,' has been included in the March, 2008, Work, Stress, and Health conference, in Washington, DC. This brief note describes the development of the criteria used to evaluate the manuscripts. The criteria are discussed with respect to (a) improving the science of evaluation methodology, (b) promoting the highest ethical standards in intervention evaluation, and (c) using the current criteria as a starting point for continuing to raise the bar for evaluation methodology. The policy implications of the evaluation criteria are discussed as well.
JF  - Journal of Occupational Health Psychology
AU  - Scharf, Ted
AU  - Chapman, Larry
AU  - Collins, Jim
AU  - Limanowski, Julia
AU  - Heaney, Cathy
AU  - Goldenhar, Linda M
AD  - Division of Applied Research and Technology, NIOSH, Cincinnati, Ohio, tscharf@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 1
EP  - 9
PB  - American Psychological Association, 750 First St., N.E. Washington DC 20002-4242 USA, [mailto:journals@apa.org], [URL:http://www.apa.org/]
VL  - 13
IS  - 1
SN  - 1076-8998, 1076-8998
KW  - Health & Safety Science Abstracts
KW  - Conferences
KW  - Occupational safety
KW  - Stress
KW  - best practices
KW  - Ethics
KW  - intervention
KW  - USA, Florida, Miami
KW  - Occupational health
KW  - H 1000:Occupational Safety and Health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20978282?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+Health+Psychology&rft.atitle=Intervention+Effectiveness+Evaluation+Criteria%3A+Promoting+Competitions+and+Raising+the+Bar&rft.au=Scharf%2C+Ted%3BChapman%2C+Larry%3BCollins%2C+Jim%3BLimanowski%2C+Julia%3BHeaney%2C+Cathy%3BGoldenhar%2C+Linda+M&rft.aulast=Scharf&rft.aufirst=Ted&rft.date=2008-01-01&rft.volume=13&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Health+Psychology&rft.issn=10768998&rft_id=info:doi/10.1037%2F1076-8998.13.1.1
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-11-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - USA, Florida, Miami; intervention; Occupational health; Stress; Conferences; best practices; Occupational safety; Ethics
DO  - http://dx.doi.org/10.1037/1076-8998.13.1.1
ER  - 



TY  - JOUR
T1  - Prevention through Design - Introduction
AN  - 20975050; 8549623
AB  - Abstract not available.
JF  - Journal of Safety Research
AU  - Howard, John
AD  - Director, National Institute for Occupational Safety and Health, jhoward1@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 113
PB  - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl]
VL  - 39
IS  - 2
SN  - 0022-4375, 0022-4375
KW  - Health & Safety Science Abstracts
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20975050?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Prevention+through+Design+-+Introduction&rft.au=Howard%2C+John&rft.aulast=Howard&rft.aufirst=John&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.022
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-11-01
N1  - Last updated - 2011-12-14
DO  - http://dx.doi.org/10.1016/j.jsr.2008.02.022
ER  - 



TY  - RPRT
T1  - A Tree Trimmer Dies When He is Pulled into a Wood Chipper
AN  - 20967607; 11069910
AB  - A Hispanic male tree trimmer died after he was pulled into a wood chipper while feeding branches into the machine. The victim was part of a two-man crew that was trimming trees along a residential street when the incident occurred. The wood chipper had a built-in safety device called the feed control bar that was located on the top and both sides of the feed chute, however it is not known if it was working at the time of the incident. The CA/FACE investigator determined that, in order to prevent future occurrences, employers, as part of their Injury and Illness Prevention Program (IIPP), should: Ensure that employees never operate a wood chipper alone. Ensure that all employees stand to the side of the feed table when feeding trimmings into the wood chipper. Ensure that employees are thoroughly trained and tested on the operation of wood chippers. Ensure that a documented inspection report is completed every time a wood chipper is used and kept on file.
JF  - A Tree Trimmer Dies When He is Pulled into a Wood Chipper. [np]. 2008.
AU  - Anonymous
Y1  - 2008
PY  - 2008
DA  - 2008
PB  - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html]
KW  - Health & Safety Science Abstracts
KW  - Injuries
KW  - Trees
KW  - feeding
KW  - Wood
KW  - inspection
KW  - prevention
KW  - Ethnic groups
KW  - Feeds
KW  - H 11000:Diseases/Injuries/Trauma
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967607?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Tree+Trimmer+Dies+When+He+is+Pulled+into+a+Wood+Chipper&rft.title=A+Tree+Trimmer+Dies+When+He+is+Pulled+into+a+Wood+Chipper&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-10-01
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - A biocompatible medium for nanoparticle dispersion
AN  - 20944856; 8493288
AB  - Our laboratory has reported that rat bronchoalveolar lavage (BAL) fluid is an effective nanoparticle (NP) dispersant. However, its utility is constrained by its cost and the lack of standardization to control for intra- and inter-laboratory variability in BAL fluid. In this study, we report the efficacy and biocompatibility of a dispersion medium (DM), which is a 'lung fluid mimic'. In vitro studies, which used dynamic light scattering and transmission electron microscopy, determined that ultrafine titanium dioxide and ultrafine carbon black are equally well dispersed by DM or BAL fluid. We also determined that DM was effective at dispersing multi-walled carbon nanotubes. In vivo, when used as a vehicle, DM per se did not elicit toxicity and did not influence or alter toxic responses to crystalline silica in either the lung or brain. Overall, these studies indicate that DM is an effective, biocompatible, and economical vehicle for nanotoxicological studies.
JF  - Nanotoxicology
AU  - Porter, D
AU  - Sriram, K
AU  - Wolfarth, M
AU  - Jefferson, A
AU  - Schwegler-Berry, D
AU  - Andrew, ME
AU  - Castranova, V
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 144
EP  - 154
VL  - 2
IS  - 3
SN  - 1743-5390, 1743-5390
KW  - Toxicology Abstracts
KW  - Biocompatibility
KW  - Transmission electron microscopy
KW  - Brain
KW  - Light scattering
KW  - Toxicity
KW  - Dispersants
KW  - Alveoli
KW  - Standardization
KW  - Titanium dioxide
KW  - Silica
KW  - Carbon
KW  - Bronchus
KW  - Lung
KW  - nanotubes
KW  - nanoparticles
KW  - X 24350:Industrial Chemicals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20944856?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=A+biocompatible+medium+for+nanoparticle+dispersion&rft.au=Porter%2C+D%3BSriram%2C+K%3BWolfarth%2C+M%3BJefferson%2C+A%3BSchwegler-Berry%2C+D%3BAndrew%2C+ME%3BCastranova%2C+V&rft.aulast=Porter&rft.aufirst=D&rft.date=2008-01-01&rft.volume=2&rft.issue=3&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.1080%2F17435390802318349
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-10-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Biocompatibility; Transmission electron microscopy; Light scattering; Brain; Toxicity; Dispersants; Alveoli; Standardization; Carbon; Silica; Titanium dioxide; Bronchus; Lung; nanotubes; nanoparticles
DO  - http://dx.doi.org/10.1080/17435390802318349
ER  - 



TY  - JOUR
T1  - A regulatory viewpoint on transporter-based drug interactions
AN  - 20937743; 8493298
AB  - 1. Pharmacokinetic drug interactions can lead to serious adverse events and the evaluation of a new molecular entity's (NME) drug-drug interaction potential is an integral part of drug development and regulatory review before its market approval. Clinically relevant interactions mediated by transporters are of increasing interest in clinical development and research in this emerging area and it has been revealed that drug transporters can play an important role in modulating drug absorption, distribution, metabolism and elimination. 2. Acting alone or in concert with drug-metabolizing enzymes transporters can affect the pharmacokinetics and/or pharmacodynamics of a drug. The newly released drug interaction guidance by the US Food and Drug Administration (USFDA) includes new information addressing drug transporter interactions with a primary focus on P-glycoprotein (P-gp, ABCB1). 3. This paper provides a regulatory viewpoint on transporters and their potential role in drug-drug interactions. It first outlines information that might be needed during drug development and ultimately included in new drug application (NDA) submissions to address potential transporter-mediated drug interactions. Next, it explains criteria that may warrant conduct of in vivo P-gp-mediated drug interaction studies based on in vitro assessment. In addition, it includes a review case that describes the evaluation of data suggesting a P-gp-based induction interaction.
JF  - Xenobiotica
AU  - Zhang, L
AU  - Zhang, Y
AU  - Strong, J M
AU  - Reynolds, K S
AU  - Huang, S-M
AD  - Offices of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 709
EP  - 724
VL  - 38
IS  - 7/8
SN  - 0049-8254, 0049-8254
KW  - Toxicology Abstracts
KW  - Drug interaction
KW  - P-Glycoprotein
KW  - Data processing
KW  - Reviews
KW  - Drug metabolism
KW  - Enzymes
KW  - Drug development
KW  - Pharmacokinetics
KW  - Pharmacodynamics
KW  - X 24310:Pharmaceuticals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20937743?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica&rft.atitle=A+regulatory+viewpoint+on+transporter-based+drug+interactions&rft.au=Zhang%2C+L%3BZhang%2C+Y%3BStrong%2C+J+M%3BReynolds%2C+K+S%3BHuang%2C+S-M&rft.aulast=Zhang&rft.aufirst=L&rft.date=2008-01-01&rft.volume=38&rft.issue=7%2F8&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Xenobiotica&rft.issn=00498254&rft_id=info:doi/10.1080%2F00498250802017715
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-10-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Drug interaction; P-Glycoprotein; Data processing; Drug metabolism; Reviews; Enzymes; Drug development; Pharmacodynamics; Pharmacokinetics
DO  - http://dx.doi.org/10.1080/00498250802017715
ER  - 



TY  - JOUR
T1  - Crystalline Silica is a Negative Modifier of Pulmonary Cytochrome P-4501A1 Induction
AN  - 20929287; 8173930
AB  - Polycyclic aromatic hydrocarbons (PAHs) are products of incomplete combustion that are commonly inhaled by workers in the dusty trades. Many PAHs are metabolized by cytochrome P-4501A1 (CYP1A1), which may facilitate excretion but may activate pulmonary carcinogens. PAHs also stimulate their own metabolism by inducing CYP1A1. Recent studies suggest that respirable coal dust exposure inhibits induction of pulmonary CYP1A1 using the model PAH beta -naphthoflavone. The effect of the occupational particulate respirable crystalline silica was investigated on PAH-dependent pulmonary CYP1A1 induction. Male Sprague-Dawley rats were exposed to intratracheal silica or vehicle and then intraperitoneal beta -naphthoflavone, a CYP1A1 inducer, and/or phenobarbital, an inducer of hepatic CYP2B1, or vehicle. beta -Naphthoflavone induced pulmonary CYP1A1, but silica attenuated this beta -naphthoflavone-induced CYP1A1 activity and also suppressed the activity of CYP2B1, the major constitutive CYP in rat lung. The magnitude of CYP activity suppression was similar regardless of silica exposure dose within a range of 5 to 20 mg/rat. Phenobarbital and beta -naphthoflavone had no effect on pulmonary CYP2B1 activity. Both enzymatic immunohistochemistry and immunofluorescent staining for CYP1A1 indicated that sites of CYP1A1 induction were nonciliated airway epithelial cells, endothelial cells, and the alveolar septum. Using immunofluorescent colocalization of CYP1A1 with cytokeratin 8, a marker of alveolar type II cells, the proximal alveolar region was the site of both increased alveolar type II cells and decreased proportional CYP1A1 expression in alveolar type II cells. Our findings suggest that in PAH-exposed rat lung, silica is a negative modifier of CYP1A1 induction and CYP2B1 activity.
JF  - Journal of Toxicology and Environmental Health, Part A: Current Issues
AU  - Battelli, LA
AU  - Ghanem, M M
AU  - Kashon, M L
AU  - Barger, M
AU  - Ma, JYC
AU  - Simoskevitz, R L
AU  - Miles, PR
AU  - Hubbs, A F
AD  - CDC/NIOSH, 1095 Willowdale Road, M/S L2015, Morgantown, WV 26505, USA, LBattelli@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 521
EP  - 532
VL  - 71
IS  - 7-8
SN  - 1528-7394, 1528-7394
KW  - Toxicology Abstracts
KW  - Epithelial cells
KW  - Cytochromes
KW  - Phenobarbital
KW  - Polycyclic aromatic hydrocarbons
KW  - Carcinogens
KW  - Alveoli
KW  - Combustion
KW  - Endothelial cells
KW  - Workers
KW  - beta -Naphthoflavone
KW  - Silica
KW  - Lung
KW  - Liver
KW  - Excretion
KW  - Coal dust
KW  - Cytochrome P450
KW  - Septum
KW  - Trachea
KW  - Immunohistochemistry
KW  - Metabolism
KW  - Cytokeratin
KW  - Respiratory tract
KW  - X 24350:Industrial Chemicals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20929287?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Crystalline+Silica+is+a+Negative+Modifier+of+Pulmonary+Cytochrome+P-4501A1+Induction&rft.au=Battelli%2C+LA%3BGhanem%2C+M+M%3BKashon%2C+M+L%3BBarger%2C+M%3BMa%2C+JYC%3BSimoskevitz%2C+R+L%3BMiles%2C+PR%3BHubbs%2C+A+F&rft.aulast=Battelli&rft.aufirst=LA&rft.date=2008-01-01&rft.volume=71&rft.issue=7-8&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390801907483
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Cytochromes; Epithelial cells; Polycyclic aromatic hydrocarbons; Phenobarbital; Carcinogens; Alveoli; Combustion; Endothelial cells; Workers; Silica; beta -Naphthoflavone; Lung; Liver; Coal dust; Excretion; Septum; Cytochrome P450; Immunohistochemistry; Trachea; Metabolism; Respiratory tract; Cytokeratin
DO  - http://dx.doi.org/10.1080/15287390801907483
ER  - 



TY  - JOUR
T1  - Embryonic Stem Cells Cultured in Serum-Free Medium Acquire Bovine Apolipoprotein B-100 from Feeder Cell Layers and Serum Replacement Medium
AN  - 20927458; 8043025
AB  - Previous studies have demonstrated that cell populations that are cultured with heterologous animal products can acquire xenoantigens, potentially limiting their clinical utility because of immune responses. Embryonic stem cells (ESCs) are an attractive source of multiple potential cellular therapies and are typically derived and routinely cultured on murine embryonic fibroblast (MEF) feeder cell layers in commercially available serum replacement (SR) medium or fetal calf serum (FCS)-containing medium. Recently, we found that a strong antibody response was generated in human subjects after the second infusion of therapeutic cells cultured in FCS-containing medium. This response was specific for bovine apolipoprotein B-100 (apoB-100), which is the major protein component of low-density lipoproteins (LDL) and which targets its binding to abundant low-density lipoprotein receptors on the cell surface, from which it is internalized. Here, we have shown that ESCs cultured on MEFs in SR medium acquired bovine apoB-100 from MEFs and from the SR medium as well. Our findings also suggest that bovine LDL are used as critical nutrients for ESC propagation. Disclosure of potential conflicts of interest is found at the end of this article.
JF  - Stem Cells
AU  - Hisamatsu-Sakamoto, Michiko
AU  - Sakamoto, Norihisa
AU  - Rosenberg, Amy S
AD  - Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA. Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 72
EP  - 78
PB  - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA
VL  - 26
IS  - 1
SN  - 1066-5099, 1066-5099
KW  - Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW  - Cell surface
KW  - Fetal calf serum
KW  - xenoantigens
KW  - Nutrients
KW  - lipoprotein receptors
KW  - Antibody response
KW  - Lipoproteins (low density)
KW  - Stem cells
KW  - serum-free medium
KW  - Embryo cells
KW  - Embryo fibroblasts
KW  - Lipoproteins
KW  - W 30905:Medical Applications
KW  - G 07730:Development & Cell Cycle
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20927458?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenotransplantation&rft.atitle=National+policies+for+xenotransplantation+in+the+USA&rft.au=Bloom%2C+Eda+T&rft.aulast=Bloom&rft.aufirst=Eda&rft.date=2007-07-01&rft.volume=14&rft.issue=4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Xenotransplantation&rft.issn=0908665X&rft_id=info:doi/10.1111%2Fj.1399-3089.2007.00396.x
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-03-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Cell surface; serum-free medium; Stem cells; Embryo cells; Fetal calf serum; Lipoproteins; xenoantigens; Embryo fibroblasts; Nutrients; Antibody response; lipoprotein receptors; Lipoproteins (low density)
ER  - 



TY  - JOUR
T1  - Chemical Imaging of Pharmaceutical Materials: Fabrication of Micropatterned Resolution Targets
AN  - 20916306; 8424022
AB  - Resolution targets composed of thick poly(ethylene glycol) (PEG) lines on silicon substrates have been fabricated using the method of micromolding in capillaries (MiMIC). Patterns of three parallel lines with equal width and spacing have been prepared, with widths between 5 and 25 mu m. Raman chemical images of the PEG-on-silicon devices as well as the metal-on-glass masks used to prepare the devices were measured. The Raman images were used to determine the impulse response of the instrument by comparing the measured images to model functions prepared by convolution of a test impulse function with the object functions of the devices. Impulse widths for PEG-on-silicon targets were approximately two times greater than impulse widths for metal-on-glass targets. The results provide a quantitative measure of the influence of light-matter interactions on the spatial resolution achievable with chemical imaging instruments. This work shows that microfluidic channels can be used to produce robust patterns of PEG on silicon, and these patterns are realistic resolution targets for spectroscopic chemical imaging of pharmaceutical materials.
JF  - Analytical Chemistry (Washington)
AU  - Gilliam, Sean J
AU  - Martin, RScott
AU  - Kauffman, John F
AD  - Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 5706
EP  - 5712
PB  - American Chemical Society, Box 3337 Columbus OH 43210 USA, [mailto:service@acs.org]
VL  - 80
IS  - 15
SN  - 0003-2700, 0003-2700
KW  - Biotechnology and Bioengineering Abstracts
KW  - Silicon
KW  - Microfluidics
KW  - Pharmaceuticals
KW  - spatial discrimination
KW  - imaging
KW  - Polyethylene glycol
KW  - Capillaries
KW  - Models
KW  - W 30910:Imaging
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20916306?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=Chemical+Imaging+of+Pharmaceutical+Materials%3A+Fabrication+of+Micropatterned+Resolution+Targets&rft.au=Gilliam%2C+Sean+J%3BMartin%2C+RScott%3BKauffman%2C+John+F&rft.aulast=Gilliam&rft.aufirst=Sean&rft.date=2008-01-01&rft.volume=80&rft.issue=15&rft.spage=5706&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac800864x
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-09-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Microfluidics; Silicon; Pharmaceuticals; spatial discrimination; Capillaries; Polyethylene glycol; imaging; Models
DO  - http://dx.doi.org/10.1021/ac800864x
ER  - 



TY  - JOUR
T1  - Projected Cost-effectiveness of New Vaccines for Adolescents in the United States
AN  - 20892463; 7937049
AB  - BACKGROUND. Economic assessments that guide policy making on immunizations are becoming increasingly important in light of new and anticipated vaccines for adolescents. However, important considerations that limit the utility of these assessments, such as the diversity of approaches used, are often overlooked and should be better understood. OBJECTIVE. Our goal was to examine economic studies of adolescent vaccines and compare cost-effectiveness outcomes among studies on a particular vaccine, across adolescent vaccines, and between new adolescent vaccines versus vaccines that are recommended for young children. METHODS. A systematic review of economic studies on immunizations for adolescents was conducted. Studies were identified by searching the Medline, Embase, and EconLit databases. Each study was reviewed for appropriateness of model design, baseline setup, sensitivity analyses, and input variables (ie, epidemiologic, clinical, cost, and quality-of-life impact). For comparison, the cost-effectiveness outcomes reported in key studies on vaccines for younger children were selected. RESULTS. Vaccines for healthy adolescents were consistently found to be more costly than the health care or societal cost savings they produced and, in general, were less cost-effective than vaccines for younger children. Among the new vaccines, pertussis and human papillomavirus vaccines were more cost-effective than meningococcal vaccines. Including herd-immunity benefits in studies significantly improved the cost-effectiveness estimates for new vaccines. Differences in measurements or assumptions limited further comparisons. CONCLUSION. Although using the new adolescent vaccines is unlikely to be cost-saving, vaccination programs will result in sizable health benefits.
JF  - Pediatrics
AU  - Ortega-Sanchez, Ismael R
AU  - Lee, Grace M
AU  - Jacobs, RJake
AU  - Prosser, Lisa A
AU  - Molinari, Noelle-Angelique
AU  - Zhang, Xinzhi
AU  - Baine, William B
AU  - McCauley, Mary M
AU  - Miller, Ted
AD  - National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts. Division of Infectious Diseases, Children's Hospital Boston, Boston, Massachusetts. Capitol Outcomes Research, Inc, Alexandria, Virginia. National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Maryland. Pacific Institute for Research and Evaluation, Calverton, Maryland
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - S63
EP  - S78
PB  - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org]
VL  - 121
IS  - Supplement_1
SN  - 0031-4005, 0031-4005
KW  - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Biotechnology and Bioengineering Abstracts
KW  - Databases
KW  - Pertussis
KW  - Adolescence
KW  - Reviews
KW  - Economics
KW  - Neisseria meningitidis
KW  - Vaccines
KW  - Children
KW  - Human papillomavirus
KW  - Models
KW  - F 06905:Vaccines
KW  - J 02350:Immunology
KW  - W 30915:Pharmaceuticals & Vaccines
KW  - V 22400:Human Diseases
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20892463?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Projected+Cost-effectiveness+of+New+Vaccines+for+Adolescents+in+the+United+States&rft.au=Ortega-Sanchez%2C+Ismael+R%3BLee%2C+Grace+M%3BJacobs%2C+RJake%3BProsser%2C+Lisa+A%3BMolinari%2C+Noelle-Angelique%3BZhang%2C+Xinzhi%3BBaine%2C+William+B%3BMcCauley%2C+Mary+M%3BMiller%2C+Ted&rft.aulast=Ortega-Sanchez&rft.aufirst=Ismael&rft.date=2008-01-01&rft.volume=121&rft.issue=Supplement_1&rft.spage=S63&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-02-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Pertussis; Databases; Reviews; Adolescence; Economics; Vaccines; Children; Models; Neisseria meningitidis; Human papillomavirus
ER  - 



TY  - JOUR
T1  - Unsupervised estimation of myocardial displacement from tagged MR sequences using nonrigid registration
AN  - 20857535; 8368679
AB  - We propose a fully automatic cardiac motion estimation technique that uses nonrigid registration between temporally adjacent images to compute the myocardial displacement field from tagged MR sequences using as inputs (sources) both horizontally and vertically tagged images. We present a new multisource nonrigid registration algorithm employing a semilocal deformation model that provides controlled smoothness. The method requires no segmentation. We apply a multiresolution optimization strategy for better speed and robustness. The accuracy of the algorithm is assessed on experimental data (animal model) and healthy volunteer data by calculating the root mean square (RMS) difference in position between the estimated tag trajectories and manual tracings outlined by an expert. For the 20000 tag lines analyzed (45 slices over 20-40 time frames), the RMS difference between the automatic tag trajectories and the manually segmented tag trajectories was 0.51 pixels (0.25 mm) for the animal data and 0.49 pixels (0.49 mm) for the human volunteer data. The RMS difference in the separation between adjacent tag lines (RMS_TS) was also assessed, resulting in an RMS_TS of 0.40 pixels (0.19 mm) in the experimental data and 0.52 pixels (0.56 mm) in the volunteer data. These results confirm the subpixel accuracy achieved using the proposed methodology. Magn Reson Med 2007.
JF  - Magnetic Resonance in Medicine
AU  - Ledesma-Carbayo, Maria J
AU  - Derbyshire, J Andrew
AU  - Sampath, Smita
AU  - Santos, Andres
AU  - Desco, Manuel
AU  - McVeigh, Elliot R
AD  - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, emcveigh@nih.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 181
EP  - 189
PB  - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/]
VL  - 59
IS  - 1
SN  - 0740-3194, 0740-3194
KW  - Biotechnology and Bioengineering Abstracts
KW  - Heart
KW  - Data processing
KW  - Segmentation
KW  - Animal models
KW  - Algorithms
KW  - Image processing
KW  - N.M.R.
KW  - W 30910:Imaging
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857535?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Unsupervised+estimation+of+myocardial+displacement+from+tagged+MR+sequences+using+nonrigid+registration&rft.au=Ledesma-Carbayo%2C+Maria+J%3BDerbyshire%2C+J+Andrew%3BSampath%2C+Smita%3BSantos%2C+Andres%3BDesco%2C+Manuel%3BMcVeigh%2C+Elliot+R&rft.aulast=Ledesma-Carbayo&rft.aufirst=Maria&rft.date=2008-01-01&rft.volume=59&rft.issue=1&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21444
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-08-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Data processing; Algorithms; N.M.R.; Animal models; Segmentation; Image processing; Heart
DO  - http://dx.doi.org/10.1002/mrm.21444
ER  - 



TY  - JOUR
T1  - Mercaptobenzothiazole allergenicity--role of the thiol group
AN  - 20853672; 8349363
AB  - The rubber accelerator, 2-mercaptobenzothiazole (MBT), is known to cause allergic contact dermatitis (ACD), but the mechanism is unknown. The role of the thiol group in MBT's allergenicity was investigated in the present study. Guinea pigs were sensitized to MBT using a modified guinea pig maximization test (GPMT) and reactivity was assessed toward 2-mer-captobenzothiazole disulfide (MBTS), 2-hydroxybenzothiazole (HBT; thiol-substituted), 2-(methylthio)benzothiazok (MTBT; thiol-blocked), and benzothiazole (BT; thiol-lacking). MBT and MBTS, but not BT, HBT, or MTBT, elicited ACD in MBT-sensitized animals, demonstrating that the tliiol group is critical to MBT's allergenicity. In addition, both MBT and MBTS were shown to inhibit both glutathione reductase and thioredoxin reductase, and thus contribute to the stability of MBT-protein mixed disulfides. It is concluded that the probable haptenation mechanism of MBT is through initial oxidation to MBTS with subsequent reduction to form mixed disulfides with proteins.
JF  - Cutaneous and Ocular Toxicology
AU  - Chipinda, I
AU  - Zhang, X-D
AU  - Simoyi, R H
AU  - Siegel, P D
AD  - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA, pds3@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 103
EP  - 116
VL  - 27
IS  - 2
SN  - 1556-9527, 1556-9527
KW  - mercaptobenzothiazole
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - glutathione reductase
KW  - Contact dermatitis
KW  - Allergenicity
KW  - Thioredoxin-disulfide reductase
KW  - Rubber
KW  - Mixed disulfides
KW  - contact dermatitis
KW  - Thiols
KW  - Oxidation
KW  - Benzothiazole
KW  - Proteins
KW  - H 14000:Toxicology
KW  - X 24360:Metals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20853672?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenotransplantation&rft.atitle=Characterization+and+expansion+of+baboon+CD4+super%28%2B%29CD25+super%28%2B%29+Treg+cells+for+potential+use+in+a+non-human+primate+xenotransplantation+model&rft.au=Porter%2C+Cynthia+M%3BHorvath-Arcidiacono%2C+Judith+A%3BSingh%2C+Avneesh+K%3BHorvath%2C+Keith+A%3BBloom%2C+Eda+T%3BMohiuddin%2C+Muhammad+M&rft.aulast=Porter&rft.aufirst=Cynthia&rft.date=2007-07-01&rft.volume=14&rft.issue=4&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Xenotransplantation&rft.issn=0908665X&rft_id=info:doi/10.1111%2Fj.1399-3089.2007.00416.x
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - glutathione reductase; Mixed disulfides; Contact dermatitis; Allergenicity; Oxidation; Thiols; Benzothiazole; Rubber; Thioredoxin-disulfide reductase; contact dermatitis; Proteins
DO  - http://dx.doi.org/10.1080/15569520701713008
ER  - 



TY  - JOUR
T1  - Comparison of Escherichia coli O157:H7 Enrichment in Spiked Produce Samples
AN  - 20845919; 8027180
AB  - Two strains of Escherichia coli O157:H7 were spiked into six varieties of produce at approximately 0.5 CFU g super(-1). Samples were enriched by using the U.S. Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) method and by using an experimental method incorporating acid shock. Target colonies were detectable on selective agars after 30 of 48 analyses with BAM enrichment and 48 of 48 analyses with acid enrichment. Real-time PCR screening of 24-h enrichment broths revealed the presence of the diagnostic stx sub(1) or stx sub(2) genes after 27 of 48 analyses with BAM enrichment and 42 of 48 analyses with acid enrichment. The efficiency of the enrichment varied with strain and type of produce spiked but overall was better with the experimental enrichment method. Modifications of both the acid enrichment and BAM enrichment methods also were tested. The acid method with a modified incubation temperature consistently yielded high rates of recovery (>10 super(8) CFU ml super(-1)), with no instances in which target cells could not be detected. Modification of the BAM procedure did not reproducibly improve enrichment efficiency.
JF  - Journal of Food Protection
AU  - Grant, Michael A
AD  - U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Drive S.E., Bothell, Washington 98021, USA
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 139
EP  - 145
PB  - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com]
VL  - 71
IS  - 1
SN  - 0362-028X, 0362-028X
KW  - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - Temperature effects
KW  - Agar
KW  - Colonies
KW  - Shock
KW  - Colony-forming cells
KW  - Escherichia coli
KW  - Polymerase chain reaction
KW  - J 02320:Cell Biology
KW  - A 01330:Food Microbiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20845919?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-03-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Temperature effects; Agar; Colonies; Shock; Colony-forming cells; Polymerase chain reaction; Escherichia coli
DO  - http://dx.doi.org/10.1043/0362-028X(2008)71%3C139:RNCOCO%3E2.3.CO;2
ER  - 



TY  - JOUR
T1  - A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells
AN  - 20819907; 8243987
AB  - Kupffer cells are a major barrier to systemic adenovirus (Ad) gene therapy because they rapidly and efficiently clear virions from the circulation. The lack of a straightforward quantitative technique for selectively measuring uptake of Ad by Kupffer cells has made it difficult to study the mechanisms by which they recognize Ad. A new method was developed that relies on immunofluorescent detection of Ad within Kupffer cells in mouse liver sections, followed by confocal microscopy and computerized image analysis. The method is sensitive, quantitative and reproducible, with a linear range spanning two orders of magnitude. As an example of the utility of this method, it was found that pre-injecting mice with polyinosinic acid reduces accumulation of Ad in Kupffer cells by approximately 90%.
JF  - Journal of Virological Methods
AU  - Smith, J S
AU  - Xu, Z
AU  - Byrnes, A P
AD  - Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA, JeffreyS.Smith@fda.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 54
EP  - 60
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 147
IS  - 1
SN  - 0166-0934, 0166-0934
KW  - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts
KW  - Expression vectors
KW  - Virions
KW  - Kupffer cells
KW  - Gene therapy
KW  - Hepatocytes
KW  - Confocal microscopy
KW  - Adenovirus
KW  - Image processing
KW  - W 30905:Medical Applications
KW  - V 22300:Methods
KW  - F 06900:Methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Virions; Expression vectors; Kupffer cells; Gene therapy; Hepatocytes; Confocal microscopy; Image processing; Adenovirus
DO  - http://dx.doi.org/10.1016/j.jviromet.2007.08.009
ER  - 



TY  - JOUR
T1  - The Fda Critical Path Initiative and Its Influence on New Drug Development
AN  - 20815063; 8190336
AB  - Societal expectations about drug safety and efficacy are rising while productivity in the pharmaceutical industry is falling. In 2004, the US Food and Drug Administration introduced the Critical Path Initiative with the intent of modernizing drug development by incorporating recent scientific advances, such as genomics and advanced imaging technologies, into the process. An important part of the initiative is the use of public-private partnerships and consortia to accomplish the needed research. This article explicates the reasoning behind the Critical Path Initiative and discusses examples of successful consortia.
JF  - Annual Review of Medicine
AU  - Woodcock, Janet
AU  - Woosley, Raymond
AD  - Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20857, Janet.Woodcock@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 1
EP  - 12
PB  - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org]
VL  - 59
SN  - 0066-4219, 0066-4219
KW  - Biotechnology and Bioengineering Abstracts
KW  - Reviews
KW  - Pharmaceuticals
KW  - Drug development
KW  - genomics
KW  - imaging
KW  - W 30910:Imaging
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20815063?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Medicine&rft.atitle=The+Fda+Critical+Path+Initiative+and+Its+Influence+on+New+Drug+Development&rft.au=Woodcock%2C+Janet%3BWoosley%2C+Raymond&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2008-01-01&rft.volume=59&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Medicine&rft.issn=00664219&rft_id=info:doi/10.1146%2Fannurev.med.59.090506.155819
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-08-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Reviews; Pharmaceuticals; Drug development; genomics; imaging
DO  - http://dx.doi.org/10.1146/annurev.med.59.090506.155819
ER  - 



TY  - JOUR
T1  - Mesenchymal stem cells in arthritic diseases
AN  - 20795692; 10885666
AB  - Mesenchymal stem cells (MSCs), the nonhematopoietic progenitor cells found in various adult tissues, are characterized by their ease of isolation and their rapid growth In vitro while maintaining their differentiation potential, allowing for extensive culture expansion to obtain large quantities suitable for therapeutic use. These properties make MSCs an ideal candidate cell type as building blocks for tissue engineering efforts to regenerate replacement tissues and repair damaged structures as encountered in various arthritic conditions. Osteoarthritis (OA) is the most common arthritic condition and, like rheumatoid arthritis (RA), presents an inflammatory environment with immunological involvement and this has been an enduring obstacle that can potentially limit the use of cartilage tissue engineering. Recent advances in our understanding of the functions of MSCs have shown that MSCs also possess potent immunosuppression and anti-inflammation effects. In addition, through secretion of various soluble factors, MSCs can influence the local tissue environment and exert protective effects with an end result of effectively stimulating regeneration in situ. This function of MSCs can be exploited for their therapeutic application in degenerative joint diseases such as RA and OA. This review surveys the advances made in the past decade which have led to our current understanding of stem cell biology as relevant to diseases of the joint. The potential involvement of MSCs in the pathophysiology of degenerative joint diseases will also be discussed. Specifically, we will explore the potential of MSC-based cell therapy of OA and RA by means of functional replacement of damaged cartilage via tissue engineering as well as their anti-inflammatory and immunosuppressive activities.
JF  - Arthritis Research & Therapy
AU  - Chen, F H
AU  - Tuan, R S
AD  - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Building 50, 50 South Dr., Bethesda, MD 20892, USA
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 223
VL  - 10
IS  - 5
SN  - 1478-6354, 1478-6354
KW  - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts
KW  - Cartilage diseases
KW  - Osteoarthritis
KW  - Joint diseases
KW  - Therapeutic applications
KW  - Cell culture
KW  - Inflammation
KW  - Differentiation
KW  - Stem cells
KW  - Rheumatoid arthritis
KW  - Reviews
KW  - Mesenchyme
KW  - Immunosuppression
KW  - T 2030:Cartilage and Cartilage Diseases
KW  - W 30920:Tissue Engineering
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-09-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Differentiation; Rheumatoid arthritis; Stem cells; Cartilage diseases; Osteoarthritis; Reviews; Joint diseases; Therapeutic applications; Cell culture; Mesenchyme; Immunosuppression; Inflammation
DO  - http://dx.doi.org/10.1186/ar2514
ER  - 



TY  - JOUR
T1  - The Role of Standards and Guidance in Advancing Device Technology
AN  - 20791189; 8334218
AB  - Advancing medical device technology from the design to delivery to patients takes many steps, typically including design or modification of an existing device, bench or laboratory testing, risk analysis, clinical testing (if appropriate), review of the device by regulatory agencies, and post-market surveillance by both the regulatory agency and the manufacturer. The development of technical guidance documents or international standards has made this process more efficient in the United States, though these processes are both underutilized and underappreciated. The history of the use of these approaches will be described, as well as recent progress and how the future of guidance and standards may evolve.
JF  - Journal of Biolaw & Business
AU  - Kessler, L
AU  - Herman, CL
AD  - Office of Science and Engineering Laboratories of the Center for Devices and Radiological Health (CDRH), Food and Drug Administration
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 10
EP  - 14
VL  - 11
IS  - 1
SN  - 1095-5127, 1095-5127
KW  - Risk Abstracts
KW  - Historical account
KW  - Laboratory testing
KW  - medical equipment
KW  - USA
KW  - Reviews
KW  - International standardization
KW  - Technology
KW  - R2 23020:Technological risks
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - USA; Technology; Reviews; Laboratory testing; Historical account; medical equipment; International standardization
ER  - 



TY  - JOUR
T1  - The Rules Are Old, But the Game Is Changing: Life Sciences and the Foreign Corrupt Practices Act
AN  - 20785977; 8334220
AB  - The Foreign Corrupt Practices Act turned 30 this year. Historically life sciences companies have not focused extensively on compliance with this decades-old statute, as enforcement actions were relatively few and tended to target companies in other industries. But as the biotechnology industry and the FCPA enter their fourth decade the game is changing. Regulators are ramping up overall enforcement and increasing their scrutiny of life sciences companies. This increased enforcement coincides with industry trends towards increased cross-border relationships and access to emerging markets. This article discusses this environment of heightened risk and provides insights for companies looking to mitigate risk and play by the changing rules of the game.
JF  - Journal of Biolaw & Business
AU  - Acosta, T
AD  - U.S. Department of Health and Human Services (OIG) in Washington, DC, USA
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 19
EP  - 21
VL  - 11
IS  - 1
SN  - 1095-5127, 1095-5127
KW  - Foreign Corrupt Practices Act
KW  - Risk Abstracts
KW  - Historical account
KW  - emerging markets
KW  - Compliance
KW  - Biotechnology
KW  - Legislation
KW  - R2 23090:Policy and planning
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biolaw+%26+Business&rft.atitle=The+Rules+Are+Old%2C+But+the+Game+Is+Changing%3A+Life+Sciences+and+the+Foreign+Corrupt+Practices+Act&rft.au=Acosta%2C+T&rft.aulast=Acosta&rft.aufirst=T&rft.date=2008-01-01&rft.volume=11&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biolaw+%26+Business&rft.issn=10955127&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Compliance; Legislation; Historical account; emerging markets; Biotechnology
ER  - 



TY  - JOUR
T1  - Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study
AN  - 20735944; 8035947
AB  - Meats cooked at high temperatures, such as pan-frying or grilling, are a source of carcinogenic heterocyclic amines and polycyclic aromatic hydrocarbons. We prospectively examined the association between meat types, meat cooking methods, meat doneness, and meat mutagens and the risk for prostate cancer in the Agricultural Health Study. We estimated relative risks and 95% confidence intervals (95% CI) for prostate cancer using Cox proportional hazards regression using age as the underlying time metric and adjusting for state of residence, race, smoking status, and family history of prostate cancer. During 197,017 person-years of follow-up, we observed 668 incident prostate cancer cases (613 of these were diagnosed after the first year of follow-up and 140 were advanced cases) among 23,080 men with complete dietary data. We found no association between meat type or specific cooking method and prostate cancer risk. However, intake of well or very well done total meat was associated with a 1.26-fold increased risk of incident prostate cancer (95% CI, 1.02-1.54) and a 1.97-fold increased risk of advanced disease (95% CI, 1.26-3.08) when the highest tertile was compared with the lowest. Risks for the two heterocyclic amines 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline and 2-amino-3,8-dimethylimidazo-[4,5-b]quinoxaline were of borderline significance for incident disease [1.24 (95% CI, 0.96-1.59) and 1.20 (95% CI, 0.93-1.55), respectively] when the highest quintile was compared with the lowest. In conclusion, well and very well done meat was associated with an increased risk for prostate cancer in this cohort. (Cancer Epidemiol Biomarkers Prev 2008; 17(1):80-7)
JF  - Cancer Epidemiology, Biomarkers & Prevention
AU  - Koutros, Stella
AU  - Cross, Amanda J
AU  - Sandler, Dale P
AU  - Hoppin, Jane A
AU  - Ma, Xiaomei
AU  - Zheng, Tongzhang
AU  - Alavanja, Michael CR
AU  - Sinha, Rashmi
AD  - Occupational and Environmental Epidemiology Branch and Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 80
EP  - 87
PB  - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/]
VL  - 17
IS  - 1
SN  - 1055-9965, 1055-9965
KW  - Risk Abstracts
KW  - Mutagens
KW  - Age
KW  - Smoking
KW  - Genetics
KW  - Carcinogenicity
KW  - prevention
KW  - cooking
KW  - prostate cancer
KW  - Diets
KW  - Bioindicators
KW  - Amines
KW  - Cancer
KW  - polycyclic aromatic hydrocarbons
KW  - high temperature
KW  - R2 23060:Medical and environmental health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-10-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - prostate cancer; Cancer; Bioindicators; cooking; Mutagens; Amines; Genetics; Carcinogenicity; Diets; polycyclic aromatic hydrocarbons; prevention; high temperature; Smoking; Age
ER  - 



TY  - JOUR
T1  - A regulatory perspective on the development of gene therapy for Parkinson's disease
AN  - 20734385; 8750614
JF  - Experimental Neurology
AU  - Havert, Michael B
AD  - Food and Drug Administration, Center for Biologics Evaluation and Review, Office of Cellular, Tissue, and Gene Therapies, Division of Cellular and Gene Therapies, 1401 Rockville Pike, HFM-720, Rockville, MD 20852, USA, mike.havert@fda.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 48
EP  - 50
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 209
IS  - 1
SN  - 0014-4886, 0014-4886
KW  - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts
KW  - Neurodegenerative diseases
KW  - Movement disorders
KW  - Gene therapy
KW  - Parkinson's disease
KW  - W 30905:Medical Applications
KW  - N3 11023:Neurogenetics
KW  - G 07730:Development & Cell Cycle
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Neurology&rft.atitle=A+regulatory+perspective+on+the+development+of+gene+therapy+for+Parkinson%27s+disease&rft.au=Havert%2C+Michael+B&rft.aulast=Havert&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=209&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Experimental+Neurology&rft.issn=00144886&rft_id=info:doi/10.1016%2Fj.expneurol.2007.08.010
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Movement disorders; Gene therapy; Parkinson's disease
DO  - http://dx.doi.org/10.1016/j.expneurol.2007.08.010
ER  - 



TY  - JOUR
T1  - Structure and Function of the Virulence-Associated High-Temperature Requirement A of Mycobacterium tuberculosis
AN  - 20712785; 8236740
AB  - The high-temperature requirement A (HtrA) family of serine proteases has been shown to play an important role in the environmental and cellular stress damage control system in Escherichia coli. Mycobacterium tuberculosis (Mtb) has three putative HtrA-like proteases, HtrA1, HtrA2, and HtrA3. The deletion of htrA2 gives attenuated virulence in a mouse model of TB. Biochemical analysis reveals that HtrA2 can function both as a protease and as a chaperone. The three-dimensional structure of HtrA2 determined at 2.0 Aa resolution shows that the protease domains form the central core of the trimer and the PDZ domains extend to the periphery. Unlike E. coli DegS and DegP, the protease is naturally active due to the formation of the serine protease-like catalytic triad and its uniquely designed oxyanion hole. Both protease and PDZ binding pockets of each HtrA2 molecule are occupied by autoproteolytic peptide products and reveal clues for a novel autoregulatory mechanism that might have significant importance in HtrA-associated virulence of Mtb.
JF  - Biochemistry (Washington)
AU  - Russell, David H
AU  - Jacobs, William R
AU  - MohamedMohaideen, Nilofar N
AU  - Williams, Brad J
AU  - Sacchettini, James C
AU  - Palaninathan, Satheesh K
AU  - Morin, Paul M
AU  - Braunstein, Miriam
AU  - Tichy, Shane E
AU  - Locker, Joseph
AD  - Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, Department of Chemistry, Texas A&M University, College Station, Texas 77842, Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, U.S. Food and Drug Administration, Microbiological Sciences Branch, Jamaica, New York 11433, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599
Y1  - 2008///0,
PY  - 2008
DA  - 0, 2008
SP  - 6092
EP  - 6102
PB  - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org]
VL  - 47
IS  - 23
SN  - 0006-2960, 0006-2960
KW  - Microbiology Abstracts B: Bacteriology
KW  - Virulence
KW  - Serine proteinase
KW  - Structure-function relationships
KW  - Escherichia coli
KW  - Animal models
KW  - Biochemical analysis
KW  - Stress
KW  - Tuberculosis
KW  - Chaperones
KW  - Serine
KW  - Mycobacterium tuberculosis
KW  - J 02410:Animal Diseases
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Structure+and+Function+of+the+Virulence-Associated+High-Temperature+Requirement+A+of+Mycobacterium+tuberculosis&rft.au=Russell%2C+David+H%3BJacobs%2C+William+R%3BMohamedMohaideen%2C+Nilofar+N%3BWilliams%2C+Brad+J%3BSacchettini%2C+James+C%3BPalaninathan%2C+Satheesh+K%3BMorin%2C+Paul+M%3BBraunstein%2C+Miriam%3BTichy%2C+Shane+E%3BLocker%2C+Joseph&rft.aulast=Russell&rft.aufirst=David&rft.date=2008-01-01&rft.volume=47&rft.issue=23&rft.spage=6092&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi701929m
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2016-05-27
N1  - SubjectsTermNotLitGenreText - Virulence; Serine proteinase; Structure-function relationships; Animal models; Stress; Biochemical analysis; Chaperones; Tuberculosis; Serine; Escherichia coli; Mycobacterium tuberculosis
DO  - http://dx.doi.org/10.1021/bi701929m
ER  - 



TY  - JOUR
T1  - Potential Use of DNA Barcodes in Regulatory Science: Applications of the Regulatory Fish Encyclopedia
AN  - 20686448; 8027193
AB  - The use of a DNA-based identification system (DNA barcoding) founded on the mitochondrial gene cytochrome c oxidase subunit I (COI) was investigated for updating the U.S. Food and Drug Administration Regulatory Fish Encyclopedia (RFE; http://www.cfsan.fda.gov/ similar to frf/rfe0.html). The RFE is a compilation of data used to identify fish species. It was compiled to help regulators identify species substitution that could result in potential adverse health consequences or could be a source of economic fraud. For each of many aquatic species commonly sold in the United States, the RFE includes high-resolution photographs of whole fish and their marketed product forms and species-specific biochemical patterns for authenticated fish species. These patterns currently include data from isoelectric focusing studies. In this article, we describe the generation of DNA barcodes for 172 individual authenticated fish representing 72 species from 27 families contained in the RFE. These barcode sequences can be used as an additional identification resource. In a blind study, 60 unknown fish muscle samples were barcoded, and the results were compared with the RFE barcode reference library. All 60 samples were correctly identified to species based on the barcoding data. Our study indicates that DNA barcoding can be a powerful tool for species identification and has broad potential applications.
JF  - Journal of Food Protection
AU  - Yancy, Haile F
AU  - Zemlak, Tyler S
AU  - Mason, Jacquline A
AU  - Washington, Jewell D
AU  - Tenge, Bradley J
AU  - Nguyen, Ngoc-Lan T
AU  - Barnett, James D
AU  - Savary, Warren E
AU  - Hill, Walter E
AU  - Moore, Michelle M
AU  - Fry, Frederick S
AU  - Randolph, Spring C
AU  - Rogers, Patricia L
AU  - Hebert, Paul DN
AD  - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, Maryland 20708, USA
Y1  - 2008/01//
PY  - 2008
DA  - January 2008
SP  - 210
EP  - 217
PB  - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com]
VL  - 71
IS  - 1
SN  - 0362-028X, 0362-028X
KW  - ASFA Marine Biotechnology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Biochemistry Abstracts 2: Nucleic Acids
KW  - Biological surveys
KW  - Institutional resources
KW  - Nucleotide sequence
KW  - Muscles
KW  - Mitochondria
KW  - Cytochrome-c oxidase
KW  - Isoelectric focusing
KW  - Fishery biology
KW  - Pisces
KW  - Population genetics
KW  - USA
KW  - Encyclopaedias
KW  - Economics
KW  - Photographs
KW  - DNA
KW  - Nature conservation
KW  - Q5 08523:Conservation, wildlife management and recreation
KW  - Q4 27740:Products
KW  - Q1 08109:Books, atlases and charts
KW  - N 14810:Methods
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Potential+Use+of+DNA+Barcodes+in+Regulatory+Science%3A+Applications+of+the+Regulatory+Fish+Encyclopedia&rft.au=Yancy%2C+Haile+F%3BZemlak%2C+Tyler+S%3BMason%2C+Jacquline+A%3BWashington%2C+Jewell+D%3BTenge%2C+Bradley+J%3BNguyen%2C+Ngoc-Lan+T%3BBarnett%2C+James+D%3BSavary%2C+Warren+E%3BHill%2C+Walter+E%3BMoore%2C+Michelle+M%3BFry%2C+Frederick+S%3BRandolph%2C+Spring+C%3BRogers%2C+Patricia+L%3BHebert%2C+Paul+DN&rft.aulast=Yancy&rft.aufirst=Haile&rft.date=2008-01-01&rft.volume=71&rft.issue=1&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282008%2971%253C210%3ARNPUOD%253E2.3.CO%3B2
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-03-01
N1  - Last updated - 2016-05-27
N1  - SubjectsTermNotLitGenreText - Biological surveys; Population genetics; Institutional resources; Encyclopaedias; Nucleotide sequence; Photographs; Nature conservation; DNA; Fishery biology; Economics; Muscles; Mitochondria; Cytochrome-c oxidase; Isoelectric focusing; Pisces; USA
DO  - http://dx.doi.org/10.1043/0362-028X(2008)71%3C210:RNPUOD%3E2.3.CO;2
ER  - 



TY  - JOUR
T1  - Equivalency of a personal dust monitor to the current United States coal mine respirable dust sampler
AN  - 20630633; 8045234
AB  - The United States National Institute for Occupational Safety and Health, through an informal partnership with industry, labor, and the United States Mine Safety and Health Administration, has developed and tested a new instrument known as the Personal Dust Monitor (PDM). The new dust monitor is an integral part of the cap lamp that coal miners normally carry to work and provides continuous information about the concentration of respirable coal mine dust within the breathing zone of that individual. Previous laboratory testing demonstrated that there is a 95% confidence that greater than 95% of individual PDM measurements fall within plus or minus 25% of reference measurements. The work presented in this paper focuses on the relationship between the PDM and respirable dust concentrations currently measured by a coal mine dust personal sampler unit utilizing a 10 mm Dorr-Oliver nylon cyclone. The United Kingdom Mining Research Establishment instrument, used as the basis for coal mine respirable dust standards, had been designed specifically to match the United Kingdom British Medical Research Council (BMRC) criterion. The personal sampler is used with a 1.38 multiplier to convert readings to the BMRC criterion. A stratified random sampling design incorporating a proportionate allocation strategy was used to select a sample of mechanized mining units representative of all US underground coal mines. A sample of 180 mechanized mining units was chosen, representing approximately 20% of the mechanized mining units in production at the time the sample was selected. A total of 129 valid PDM/personal sampler dust sample sets were obtained. A weighted linear regression analysis of this data base shows that, in comparison with the personal sampler, the PDM requires a mass equivalency conversion multiplier of 1.05 [95% C.I. = (1.03, 1.08)] when the small intercept term is removed from the analysis. Removal of the intercept term results in a personal sampler-equivalent concentration increase of 2.9% at a PDM measurement of 2.0 mg m super(3).
JF  - Journal of Environmental Monitoring
AU  - Page, S J
AU  - Volkwein, J C
AU  - Vinson, R P
AU  - Joy, G J
AU  - Mischler, SE
AU  - Tuchman, D P
AU  - McWilliams, L J
AD  - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 96
EP  - 101
VL  - 10
IS  - 1
SN  - 1464-0325, 1464-0325
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - Safety regulations
KW  - Laboratory testing
KW  - Coal
KW  - medical research
KW  - Dust
KW  - USA
KW  - councils
KW  - Air sampling
KW  - Mining
KW  - Occupational exposure
KW  - Data bases
KW  - Monitoring instruments
KW  - H 1000:Occupational Safety and Health
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Equivalency+of+a+personal+dust+monitor+to+the+current+United+States+coal+mine+respirable+dust+sampler&rft.au=Page%2C+S+J%3BVolkwein%2C+J+C%3BVinson%2C+R+P%3BJoy%2C+G+J%3BMischler%2C+SE%3BTuchman%2C+D+P%3BMcWilliams%2C+L+J&rft.aulast=Page&rft.aufirst=S&rft.date=2008-01-01&rft.volume=10&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb714381h
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-03-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Safety regulations; Laboratory testing; councils; Air sampling; medical research; Mining; Coal; Data bases; Occupational exposure; Dust; Monitoring instruments; USA
DO  - http://dx.doi.org/10.1039/b714381h
ER  - 



TY  - JOUR
T1  - Chronic Inhalation of Short Asbestos: Lung Fiber Burdens and Histopathology for Monkeys Maintained for 11.5 Years after Exposure
AN  - 20536496; 8017403
AB  - In an earlier report, Platek et al. (1985) presented the results of an 18-month inhalation exposure of rats and monkeys to short chrysotile asbestos. The mean chamber exposure level was 1.0 mg/m3with an average of 0.79 fibers/ml > 5 is a subset of m in length. Gross and histopathological examination of exposed and control rats indicated no treatment-related lesions. Asbestos bodies adjacent to the terminal bronchioles, but no fibrosis, were found in lung biopsy tissue taken from the exposed monkeys at 10 months post-exposure. Fifteen monkeys (9 exposed and 6 controls) from this study were maintained for 11.5 years following exposure. Lung fiber burdens were determined by transmission electron microscopy. The mean lung burden (± standard deviation) for 59 samples from exposed monkeys was 63 ± 30X 106 fibers/g dry lung (range, 18-139 X 106). The geometric mean fiber length was 3.5 is a subset of m with 35% of the fibers being > 5 is a subset of m in length. These data indicate some chrysotile fibers are durable in vivo for a significant period of time. Lungs were examined grossly and microscopically. No lesions attributable to the inhalation exposure were noted. Asbestos bodies were seen in the lungs of treated monkeys, primarily in the interstitium near bronchioles or small pulmonary blood vessels (which also may have been near to bronchioles just out of the plane of section).
JF  - Inhalation Toxicology
AU  - Stettler, Lloyd E
AU  - Sharpnack, Douglas D
AU  - Krieg, Edward F
AD  - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 63
EP  - 73
PB  - Taylor & Francis, 325 Chestnut Street Suite 800 Philadelphia PA 19106 USA, [URL:http://www.taylorandfrancis.com/]
VL  - 20
IS  - 1
SN  - 0895-8378, 0895-8378
KW  - Toxicology Abstracts
KW  - Inhalation
KW  - Fibers
KW  - Asbestos
KW  - Standard deviation
KW  - Blood vessels
KW  - Lung
KW  - Fibrosis
KW  - Transmission electron microscopy
KW  - Biopsy
KW  - Chrysotile
KW  - X 24350:Industrial Chemicals
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Brune%2C+Jurgen%3BSapko%2C+Michael%3BZipf%2C+Karl&rft.aulast=Brune&rft.aufirst=Jurgen&rft.date=2007-07-01&rft.volume=&rft.issue=&rft.spage=84p&rft.isbn=&rft.btitle=Explosion+Pressure+Design+Criteria+for+New+Seals+in+U.S.+Coal+Mines&rft.title=Explosion+Pressure+Design+Criteria+for+New+Seals+in+U.S.+Coal+Mines&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Inhalation; Fibers; Asbestos; Standard deviation; Blood vessels; Fibrosis; Lung; Transmission electron microscopy; Biopsy; Chrysotile
DO  - http://dx.doi.org/10.1080/08958370701665566
ER  - 



TY  - JOUR
T1  - Air pollution and risk of urinary bladder cancer in a case-control study in Spain
AN  - 20508662; 7936958
AB  - OBJECTIVES: Air pollution has been associated with an increased risk for lung cancer. We examined whether long-term air pollution is associated with bladder cancer risk. METHODS: Information from a case-control study in Spain that included 1219 incident cases and 1271 hospital controls was used. Information on residential history including several indicators of exposure to air pollution and other potential risk factors was collected in a face-to-face computerised personal interview. Odds ratios (OR) and 95% confidence intervals (95% CI) were adjusted for age, gender, region, smoking, occupation, water contaminants and diet. RESULTS: Living more than 40 years in a city with a population of more than 100 000 was associated with an increased risk for bladder cancer overall (OR 1.30, 95% CI 1.04 to 1.63). Emissions of polycyclic aromatic hydrocarbons and diesel from industries near the residence, as evaluated by experts, were associated with an increased risk (OR 1.29, 95% CI 0.85 to 1.98), while lower or no excess risks were observed for other pollution-related variables. Odds ratios among never smokers tended to be higher than among smokers. CONCLUSIONS: The small to moderate positive associations found for several indices of air pollution and bladder cancer, while suggestive of excess risk, require further evaluation in other settings.
JF  - Occupational and Environmental Medicine
AU  - Castano-Vinyals, Gemma
AU  - Cantor, Kenneth P
AU  - Malats, Nuria
AU  - Tardon, Adonina
AU  - Garcia-Closas, Reina
AU  - Serra, Consol
AU  - Carrato, Alfredo
AU  - Rothman, Nathaniel
AU  - Vermeulen, Roel
AU  - Silverman, Debra
AU  - Dosemeci, Mustafa
AU  - Kogevinas, Manolis
AD  - Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Barcelona, Spain. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. Universidad de Oviedo, Oviedo, Spain. Unidad de Investigacion, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain. Universitat Pompeu Fabra, Barcelona, Spain. Consorci Hospitalari Parc Tauli, Sabadell, Spain. Hospital General de Elche, Elche, Spain. Institute of Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands. Department of Social Medicine, Medical School, University of Crete, Herakleion, Crete, Greece. CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 56
EP  - 60
PB  - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK
VL  - 65
IS  - 1
SN  - 1351-0711, 1351-0711
KW  - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts; Pollution Abstracts
KW  - Historical account
KW  - Age
KW  - Spain
KW  - Pollution effects
KW  - urinary bladder
KW  - Smoking
KW  - Risk factors
KW  - Emissions
KW  - Urban areas
KW  - Lung cancer
KW  - Diets
KW  - Polycyclic aromatic hydrocarbons
KW  - Urinary bladder
KW  - Cancer
KW  - Air pollution
KW  - Gender
KW  - polycyclic aromatic hydrocarbons
KW  - Diesel
KW  - Contaminants
KW  - emergency medical services
KW  - Hospitals
KW  - X 24490:Other
KW  - R2 23060:Medical and environmental health
KW  - H 12000:Epidemiology and Public Health
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Air+pollution+and+risk+of+urinary+bladder+cancer+in+a+case-control+study+in+Spain&rft.au=Castano-Vinyals%2C+Gemma%3BCantor%2C+Kenneth+P%3BMalats%2C+Nuria%3BTardon%2C+Adonina%3BGarcia-Closas%2C+Reina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BRothman%2C+Nathaniel%3BVermeulen%2C+Roel%3BSilverman%2C+Debra%3BDosemeci%2C+Mustafa%3BKogevinas%2C+Manolis&rft.aulast=Castano-Vinyals&rft.aufirst=Gemma&rft.date=2008-01-01&rft.volume=65&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Diets; Air pollution; Smoking; Polycyclic aromatic hydrocarbons; Urinary bladder; Risk factors; Diesel; Contaminants; Lung cancer; Hospitals; Historical account; Age; Pollution effects; Cancer; urinary bladder; Gender; Emissions; polycyclic aromatic hydrocarbons; emergency medical services; Urban areas; Spain
ER  - 



TY  - JOUR
T1  - Dialysis Surveillance Report: National Healthcare Safety Network (NHSN)-Data Summary for 2006
AN  - 20473995; 9154874
AB  - AbstractThirty-two outpatient hemodialysis providers in the United States voluntarily reported 3699 adverse events to the Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN) during 2006. These providers were previously enrolled in the Dialysis Surveillance Network. The pooled mean rates of hospitalization among patients with arteriovenous fistulas, grafts, permanent and temporary central venous catheters were 7.7, 9.2, 15.7, and 34.7 per 100 patient-months, respectively. For bloodstream infection the pooled mean rates were 0.5, 0.9, 4.2, and 27.1 per 100 patient-months in these groups. Among the 599 isolates reported, 461 (77%) represented access-associated blood stream infections in patients with central lines, and 138 (23%) were in patients with fistulas or grafts. The microorganisms most frequently identified were common skin contaminants (e.g., coagulase-negative staphylococci). In 2007, enrollment in NHSN opened to all providers of outpatient hemodialysis. Specific information is available at http://www.cdc.gov/ncidod/dhqp/nhsn_FAQenrollment.html.
JF  - Seminars in Dialysis
AU  - Klevens, RMonina
AU  - Edwards, Jonathan R
AU  - Andrus, Mary L
AU  - Peterson, Kelly D
AU  - Dudeck, Margaret A
AU  - Horan, Teresa C
AD  - Division of Healthcare Quality Promotion, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, rmk2@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 24
EP  - 28
PB  - Blackwell Publishing Ltd., 9600 Garsington Road
VL  - 21
IS  - 1
SN  - 0894-0959, 0894-0959
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology
KW  - Blood
KW  - Skin
KW  - Microorganisms
KW  - Disease control
KW  - Catheters
KW  - Infection
KW  - Contaminants
KW  - Hemodialysis
KW  - A 01380:Plant Protection, Fungicides & Seed Treatments
KW  - J 02400:Human Diseases
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Dialysis&rft.atitle=Dialysis+Surveillance+Report%3A+National+Healthcare+Safety+Network+%28NHSN%29-Data+Summary+for+2006&rft.au=Klevens%2C+RMonina%3BEdwards%2C+Jonathan+R%3BAndrus%2C+Mary+L%3BPeterson%2C+Kelly+D%3BDudeck%2C+Margaret+A%3BHoran%2C+Teresa+C&rft.aulast=Klevens&rft.aufirst=RMonina&rft.date=2008-01-01&rft.volume=21&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Dialysis&rft.issn=08940959&rft_id=info:doi/10.1111%2Fj.1525-139X.2007.00379.x
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-08-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Blood; Skin; Catheters; Disease control; Microorganisms; Contaminants; Infection; Hemodialysis
DO  - http://dx.doi.org/10.1111/j.1525-139X.2007.00379.x
ER  - 



TY  - JOUR
T1  - The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
AN  - 20352121; 9023569
AB  - Background Reproducibility is a fundamental requirement in scientific experiments. Some recent publications have claimed that microarrays are unreliable because lists of differentially expressed genes (DEGs) are not reproducible in similar experiments. Meanwhile, new statistical methods for identifying DEGs continue to appear in the scientific literature. The resultant variety of existing and emerging methods exacerbates confusion and continuing debate in the microarray community on the appropriate choice of methods for identifying reliable DEG lists. Results Using the data sets generated by the MicroArray Quality Control (MAQC) project, we investigated the impact on the reproducibility of DEG lists of a few widely used gene selection procedures. We present comprehensive results from inter-site comparisons using the same microarray platform, cross-platform comparisons using multiple microarray platforms, and comparisons between microarray results and those from TaqMan - the widely regarded "standard" gene expression platform. Our results demonstrate that (1) previously reported discordance between DEG lists could simply result from ranking and selecting DEGs solely by statistical significance (P) derived from widely used simple t-tests; (2) when fold change (FC) is used as the ranking criterion with a non-stringent P-value cutoff filtering, the DEG lists become much more reproducible, especially when fewer genes are selected as differentially expressed, as is the case in most microarray studies; and (3) the instability of short DEG lists solely based on P-value ranking is an expected mathematical consequence of the high variability of the t-values; the more stringent the P-value threshold, the less reproducible the DEG list is. These observations are also consistent with results from extensive simulation calculations. Conclusion We recommend the use of FC-ranking plus a non-stringent P cutoff as a straightforward and baseline practice in order to generate more reproducible DEG lists. Specifically, the P-value cutoff should not be stringent (too small) and FC should be as large as possible. Our results provide practical guidance to choose the appropriate FC and P-value cutoffs when selecting a given number of DEGs. The FC criterion enhances reproducibility, whereas the P criterion balances sensitivity and specificity.
JF  - BMC Bioinformatics
AU  - Shi, Leming
AU  - Jones, Wendell D
AU  - Jensen, Roderick V
AU  - Harris, Stephen C
AU  - Perkins, Roger G
AU  - Goodsaid, Federico M
AU  - Guo, Lei
AU  - Croner, Lisa J
AU  - Boysen, Cecilie
AU  - Fang, Hong
AU  - Qian, Feng
AU  - Amur, Shashi
AU  - Bao, Wenjun
AU  - Barbacioru, Catalin C
AU  - Bertholet, Vincent
AU  - Cao, Xiaoxi Megan
AU  - Chu, Tzu-Ming
AU  - Collins, Patrick J
AU  - Fan, Xiao-hui
AU  - Frueh, Felix W
AU  - Fuscoe, James C
AU  - Guo, Xu
AU  - Han, Jing
AU  - Herman, Damir
AU  - Hong, Huixiao
AU  - Kawasaki, Ernest S
AU  - Li, Quan-Zhen
AU  - Luo, Yuling
AU  - Ma, Yunqing
AU  - Mei, Nan
AU  - Peterson, Ron L
AU  - Puri, Raj K
AU  - Shippy, Richard
AU  - Su, Zhenqiang
AU  - Sun, Yongming Andrew
AU  - Sun, Hongmei
AU  - Thorn, Brett
AU  - Turpaz, Yaron
AU  - Wang, Charles
AU  - Wang, Sue Jane
AU  - Warrington, Janet A
AU  - Willey, James C
AU  - Wu, Jie
AU  - Xie, Qian
AU  - Zhang, Liang
AU  - Zhang, Lu
AU  - Zhong, Sheng
AU  - Wolfinger, Russell D
AU  - Tong, Weida
AD  - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, leming.shi@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - S10
PB  - BioMed Central Ltd., Middlesex House
VL  - 9
IS  - Suppl 9
KW  - Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW  - Statistics
KW  - Data processing
KW  - Quality control
KW  - Discordance
KW  - Bioinformatics
KW  - W 30960:Bioinformatics & Computer Applications
KW  - G 07700:Molecular Genetics
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20352121?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=The+balance+of+reproducibility%2C+sensitivity%2C+and+specificity+of+lists+of+differentially+expressed+genes+in+microarray+studies&rft.au=Shi%2C+Leming%3BJones%2C+Wendell+D%3BJensen%2C+Roderick+V%3BHarris%2C+Stephen+C%3BPerkins%2C+Roger+G%3BGoodsaid%2C+Federico+M%3BGuo%2C+Lei%3BCroner%2C+Lisa+J%3BBoysen%2C+Cecilie%3BFang%2C+Hong%3BQian%2C+Feng%3BAmur%2C+Shashi%3BBao%2C+Wenjun%3BBarbacioru%2C+Catalin+C%3BBertholet%2C+Vincent%3BCao%2C+Xiaoxi+Megan%3BChu%2C+Tzu-Ming%3BCollins%2C+Patrick+J%3BFan%2C+Xiao-hui%3BFrueh%2C+Felix+W%3BFuscoe%2C+James+C%3BGuo%2C+Xu%3BHan%2C+Jing%3BHerman%2C+Damir%3BHong%2C+Huixiao%3BKawasaki%2C+Ernest+S%3BLi%2C+Quan-Zhen%3BLuo%2C+Yuling%3BMa%2C+Yunqing%3BMei%2C+Nan%3BPeterson%2C+Ron+L%3BPuri%2C+Raj+K%3BShippy%2C+Richard%3BSu%2C+Zhenqiang%3BSun%2C+Yongming+Andrew%3BSun%2C+Hongmei%3BThorn%2C+Brett%3BTurpaz%2C+Yaron%3BWang%2C+Charles%3BWang%2C+Sue+Jane%3BWarrington%2C+Janet+A%3BWilley%2C+James+C%3BWu%2C+Jie%3BXie%2C+Qian%3BZhang%2C+Liang%3BZhang%2C+Lu%3BZhong%2C+Sheng%3BWolfinger%2C+Russell+D%3BTong%2C+Weida&rft.aulast=Shi&rft.aufirst=Leming&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+9&rft.spage=S10&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S9-S10
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-03-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Data processing; Statistics; Quality control; Discordance; Bioinformatics
DO  - http://dx.doi.org/10.1186/1471-2105-9-S9-S10
ER  - 



TY  - JOUR
T1  - Application of bioinformatics-coupled experimental analysis reveals a new transport-competent nuclear localization signal in the nucleoprotein of Influenza A virus strain
AN  - 20349193; 9023642
AB  - Background Two nuclear localization sequences (NLS) in influenza A virus nucleoprotein (NP) have been demonstrated to be critical for nuclear import of NP and viral ribonucleoprotein complexes. However, a deletion mutant lacking these two signals was still able to localize to the nucleus suggesting the presence of yet another (a third) potential NLS in the NP protein. In order to identify the nature of this potential NLS signal in the NP of a WS/33L influenza virus A strain, we utilized the tools of bioinformatics coupled with functional experimental analyses in the present study. Results Comparison of the deduced aa sequence of NP of WS/33L strain with the published WS/33 NP sequences revealed that a single amino acid (aa) change (Met to Arg) at position 105 results in converting the flanking regions (between aa position 90-121, a 32-residue stretch) into two classical overlapping bipartite NLS (obpNLS). GenBank search revealed that 9 out of 500 published NP sequences contain a similar Arg at position 105 (instead of Met) with a 100% homology to the obpNLS region. Various NP-green fluorescent protein (GFP) fusion constructs with and without the signal (obpNLS-Arg super(105)) were utilized to understand the functional nature of this signal. We analyzed the transport competency of the expressed chimeric proteins in terms of their cellular localization by confocal immunofluorescence assay. Our analysis revealed that all NP-GFP constructs containing the wild-type (R super(105)) sequence localized predominantly to the nucleus. Constructs lacking the obpNLS or constructs with reverse mutation (R super(105 )to M super(105)) on the other hand exhibited predominant cytoplasmic localization pattern. Interestingly, when the 32 aa obpNLS was fused with an unrelated viral protein (rotavirus NSP6) that has been known to be cytoplasmic protein, the chimeric protein (obpNLS-NSP6) was efficiently transported into the nucleus, indicating an efficient nuclear transport function of the 32-residue obpNLS in the NP of WS/33L strain of influenza A virus. Conclusion This report while not only establishing a new NLS in the influenza A virus strain, it also reinforces the idea that proper application of bioinformatics-coupled experimental analysis serves as a powerful tool in identifying new functional signals in proteins of interest.
JF  - BMC Cell Biology
AU  - Ketha, Krishna Mohan V
AU  - Atreya, Chintamani D
AD  - Section of Cell Biology, Laboratory of Cellular Hematology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research (F.D.A.) Bethesda, MD 20892, USA, krishna.ketha@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 22
PB  - BioMed Central Ltd., Middlesex House
VL  - 9
KW  - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids
KW  - Rotavirus
KW  - Deletion mutant
KW  - double prime NP protein
KW  - Nucleoproteins
KW  - Immunofluorescence
KW  - Methionine
KW  - Nuclear transport
KW  - Homology
KW  - Influenza A virus
KW  - Ribonucleoproteins
KW  - Bioinformatics
KW  - Fusion protein
KW  - Mutation
KW  - Amino acid sequence
KW  - N 14815:Nucleotide Sequence
KW  - W 30960:Bioinformatics & Computer Applications
KW  - V 22310:Genetics, Taxonomy & Structure
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Cell+Biology&rft.atitle=Application+of+bioinformatics-coupled+experimental+analysis+reveals+a+new+transport-competent+nuclear+localization+signal+in+the+nucleoprotein+of+Influenza+A+virus+strain&rft.au=Ketha%2C+Krishna+Mohan+V%3BAtreya%2C+Chintamani+D&rft.aulast=Ketha&rft.aufirst=Krishna+Mohan&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=BMC+Cell+Biology&rft.issn=1471-2121&rft_id=info:doi/10.1186%2F1471-2121-9-22
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-03-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Nuclear transport; Deletion mutant; Homology; double prime NP protein; Nucleoproteins; Ribonucleoproteins; Fusion protein; Immunofluorescence; Bioinformatics; Mutation; Methionine; Amino acid sequence; Rotavirus; Influenza A virus
DO  - http://dx.doi.org/10.1186/1471-2121-9-22
ER  - 



TY  - JOUR
T1  - Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270 HapMap samples
AN  - 20346885; 9023576
AB  - Background Genome-wide association studies (GWAS) aim to identify genetic variants (usually single nucleotide polymorphisms [SNPs]) across the entire human genome that are associated with phenotypic traits such as disease status and drug response. Highly accurate and reproducible genotype calling are paramount since errors introduced by calling algorithms can lead to inflation of false associations between genotype and phenotype. Most genotype calling algorithms currently used for GWAS are based on multiple arrays. Because hundreds of gigabytes (GB) of raw data are generated from a GWAS, the samples are typically partitioned into batches containing subsets of the entire dataset for genotype calling. High call rates and accuracies have been achieved. However, the effects of batch size (i.e., number of chips analyzed together) and of batch composition (i.e., the choice of chips in a batch) on call rate and accuracy as well as the propagation of the effects into significantly associated SNPs identified have not been investigated. In this paper, we analyzed both the batch size and batch composition for effects on the genotype calling algorithm BRLMM using raw data of 270 HapMap samples analyzed with the Affymetrix Human Mapping 500 K array set. Results Using data from 270 HapMap samples interrogated with the Affymetrix Human Mapping 500 K array set, three different batch sizes and three different batch compositions were used for genotyping using the BRLMM algorithm. Comparative analysis of the calling results and the corresponding lists of significant SNPs identified through association analysis revealed that both batch size and composition affected genotype calling results and significantly associated SNPs. Batch size and batch composition effects were more severe on samples and SNPs with lower call rates than ones with higher call rates, and on heterozygous genotype calls compared to homozygous genotype calls. Conclusion Batch size and composition affect the genotype calling results in GWAS using BRLMM. The larger the differences in batch sizes, the larger the effect. The more homogenous the samples in the batches, the more consistent the genotype calls. The inconsistency propagates to the lists of significantly associated SNPs identified in downstream association analysis. Thus, uniform and large batch sizes should be used to make genotype calls for GWAS. In addition, samples of high homogeneity should be placed into the same batch.
JF  - BMC Bioinformatics
AU  - Hong, Huixiao
AU  - Su, Zhenqiang
AU  - Ge, Weigong
AU  - Shi, Leming
AU  - Perkins, Roger
AU  - Fang, Hong
AU  - Xu, Joshua
AU  - Chen, James J
AU  - Han, Tao
AU  - Kaput, Jim
AU  - Fuscoe, James C
AU  - Tong, Weida
AD  - Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, Huixiao.Hong@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - S17
PB  - BioMed Central Ltd., Middlesex House
VL  - 9
IS  - Suppl 9
KW  - Biotechnology and Bioengineering Abstracts
KW  - Genomes
KW  - Association analysis
KW  - Data processing
KW  - Vocalization behavior
KW  - Single-nucleotide polymorphism
KW  - Genotyping
KW  - Algorithms
KW  - Genotypes
KW  - Bioinformatics
KW  - Drugs
KW  - Gene mapping
KW  - W 30960:Bioinformatics & Computer Applications
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Assessing+batch+effects+of+genotype+calling+algorithm+BRLMM+for+the+Affymetrix+GeneChip+Human+Mapping+500+K+array+set+using+270+HapMap+samples&rft.au=Hong%2C+Huixiao%3BSu%2C+Zhenqiang%3BGe%2C+Weigong%3BShi%2C+Leming%3BPerkins%2C+Roger%3BFang%2C+Hong%3BXu%2C+Joshua%3BChen%2C+James+J%3BHan%2C+Tao%3BKaput%2C+Jim%3BFuscoe%2C+James+C%3BTong%2C+Weida&rft.aulast=Hong&rft.aufirst=Huixiao&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+9&rft.spage=S17&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S9-S17
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-03-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Genomes; Association analysis; Data processing; Vocalization behavior; Single-nucleotide polymorphism; Genotyping; Algorithms; Bioinformatics; Genotypes; Drugs; Gene mapping
DO  - http://dx.doi.org/10.1186/1471-2105-9-S9-S17
ER  - 



TY  - JOUR
T1  - Very Important Pool (VIP) genes - an application for microarray-based molecular signatures
AN  - 20346609; 9023587
AB  - Background Advances in DNA microarray technology portend that molecular signatures from which microarray will eventually be used in clinical environments and personalized medicine. Derivation of biomarkers is a large step beyond hypothesis generation and imposes considerably more stringency for accuracy in identifying informative gene subsets to differentiate phenotypes. The inherent nature of microarray data, with fewer samples and replicates compared to the large number of genes, requires identifying informative genes prior to classifier construction. However, improving the ability to identify differentiating genes remains a challenge in bioinformatics. Results A new hybrid gene selection approach was investigated and tested with nine publicly available microarray datasets. The new method identifies a Very Important Pool (VIP) of genes from the broad patterns of gene expression data. The method uses a bagging sampling principle, where the re-sampled arrays are used to identify the most informative genes. Frequency of selection is used in a repetitive process to identify the VIP genes. The putative informative genes are selected using two methods, t-statistic and discriminatory analysis. In the t-statistic, the informative genes are identified based on p-values. In the discriminatory analysis, disjoint Principal Component Analyses (PCAs) are conducted for each class of samples, and genes with high discrimination power (DP) are identified. The VIP gene selection approach was compared with the p-value ranking approach. The genes identified by the VIP method but not by the p-value ranking approach are also related to the disease investigated. More importantly, these genes are part of the pathways derived from the common genes shared by both the VIP and p-ranking methods. Moreover, the binary classifiers built from these genes are statistically equivalent to those built from the top 50 p-value ranked genes in distinguishing different types of samples. Conclusion The VIP gene selection approach could identify additional subsets of informative genes that would not always be selected by the p-value ranking method. These genes are likely to be additional true positives since they are a part of pathways identified by the p-value ranking method and expected to be related to the relevant biology. Therefore, these additional genes derived from the VIP method potentially provide valuable biological insights.
JF  - BMC Bioinformatics
AU  - Su, Zhenqiang
AU  - Hong, Huixiao
AU  - Fang, Hong
AU  - Shi, Leming
AU  - Perkins, Roger
AU  - Tong, Weida
AD  - Center for Toxicoinformatics, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), 3900 NCTR Road, Jefferson, AR 72079, USA, zhenqiang.su@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - S9
PB  - BioMed Central Ltd., Middlesex House
VL  - 9
IS  - Suppl 9
KW  - Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW  - Data processing
KW  - Principal components analysis
KW  - Hybrids
KW  - Bioinformatics
KW  - Sampling
KW  - Vasoactive intestinal peptide
KW  - DNA microarrays
KW  - biomarkers
KW  - W 30960:Bioinformatics & Computer Applications
KW  - G 07700:Molecular Genetics
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Very+Important+Pool+%28VIP%29+genes+-+an+application+for+microarray-based+molecular+signatures&rft.au=Su%2C+Zhenqiang%3BHong%2C+Huixiao%3BFang%2C+Hong%3BShi%2C+Leming%3BPerkins%2C+Roger%3BTong%2C+Weida&rft.aulast=Su&rft.aufirst=Zhenqiang&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+9&rft.spage=S9&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S9-S9
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-03-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Data processing; Hybrids; Principal components analysis; Sampling; Bioinformatics; biomarkers; DNA microarrays; Vasoactive intestinal peptide
DO  - http://dx.doi.org/10.1186/1471-2105-9-S9-S9
ER  - 



TY  - JOUR
T1  - Prospective study of physical activity and risk of postmenopausal breast cancer
AN  - 20270744; 8921933
AB  - Introduction To prospectively examine the relation of total, vigorous and non-vigorous physical activity to postmenopausal breast cancer risk. Methods We studied 32,269 women enrolled in the Breast Cancer Detection Demonstration Project Follow-up Study. Usual physical activity (including household, occupational and leisure activities) throughout the previous year was assessed at baseline using a self-administered questionnaire. Postmenopausal breast cancer cases were identified through self-reports, death certificates and linkage to state cancer registries. A Cox proportional hazards regression was used to estimate the relative risk and 95% confidence intervals of postmenopausal breast cancer associated with physical activity. Results During 269,792 person-years of follow-up from 1987 to 1998, 1506 new incident cases of postmenopausal breast cancer were ascertained. After adjusting for potential risk factors of breast cancer, a weak inverse association between total physical activity and postmenopausal breast cancer was suggested (relative risk comparing extreme quintiles = 0.87; 95% confidence interval = 0.74 to 1.02; p for trend = 0.21). That relation was almost entirely contributed by vigorous activity (relative risk comparing extreme categories = 0.87; 95% confidence interval = 0.74 to 1.02; p for trend = 0.08). The inverse association with vigorous activity was limited to women who were lean (ie, body mass index &25.0 kg/m super(2): relative risk = 0.68; 95% confidence interval = 0.54 to 0.85). In contrast, no association with vigorous activity was noted among women who were overweight or obese (ie, body mass index greater than or equal to 25.0 kg/m super(2): relative risk = 1.18; 95% confidence interval = 0.93 to 1.49; p for interaction = 0.008). Non-vigorous activity showed no relation to breast cancer (relative risk comparing extreme quintiles = 1.02; 95% confidence interval = 0.87 to 1.19; p for trend = 0.86). The physical activity and breast cancer relation was not specific to a certain hormone receptor subtype. Conclusions In this cohort of postmenopausal women, breast cancer risk reduction appeared to be limited to vigorous forms of activity; it was apparent among normal weight women but not overweight women, and the relation did not vary by hormone receptor status. Our findings suggest that physical activity acts through underlying biological mechanisms that are independent of body weight control.
JF  - Breast Cancer Research
AU  - Leitzmann, Michael F
AU  - Moore, Steven C
AU  - Peters, Tricia M
AU  - Lacey, James V
AU  - Schatzkin, Arthur
AU  - Schairer, Catherine
AU  - Brinton, Louise A
AU  - Albanes, Demetrius
AD  - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 6120 Executive Blvd., MSC 7232, Bethesda, MD 20892, USA, michael.leitzmann@klinik.uni-regensburg.de
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - R92
PB  - BioMed Central Ltd., Middlesex House
VL  - 10
IS  - 5
SN  - 1465-5411, 1465-5411
KW  - Physical Education Index
KW  - Obesity
KW  - Body mass
KW  - Women
KW  - Breasts
KW  - Exercise
KW  - Activities
KW  - Trends
KW  - Hormones
KW  - Cancer
KW  - PE 030:Exercise, Health & Physical Fitness
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+Cancer+Research&rft.atitle=Prospective+study+of+physical+activity+and+risk+of+postmenopausal+breast+cancer&rft.au=Leitzmann%2C+Michael+F%3BMoore%2C+Steven+C%3BPeters%2C+Tricia+M%3BLacey%2C+James+V%3BSchatzkin%2C+Arthur%3BSchairer%2C+Catherine%3BBrinton%2C+Louise+A%3BAlbanes%2C+Demetrius&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=10&rft.issue=5&rft.spage=R92&rft.isbn=&rft.btitle=&rft.title=Breast+Cancer+Research&rft.issn=14655411&rft_id=info:doi/10.1186%2Fbcr2190
LA  - English
DB  - Physical Education Index
N1  - Date revised - 2009-02-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Obesity; Body mass; Women; Breasts; Exercise; Trends; Activities; Hormones; Cancer
DO  - http://dx.doi.org/10.1186/bcr2190
ER  - 



TY  - JOUR
T1  - Physicochemical Characteristics of Aerosol Particles Generated During the Milling of Beryllium Silicate Ores: Implications for Risk Assessment
AN  - 20239663; 8762249
AB  - Inhalation of beryllium dusts generated during milling of ores and cutting of beryl-containing gemstones is associated with development of beryllium sensitization and low prevalence of chronic beryllium disease (CBD). Inhalation of beryllium aerosols generated during primary beryllium production and machining of the metal, alloys, and ceramics are associated with sensitization and high rates of CBD, despite similar airborne beryllium mass concentrations among these industries. Understanding the physicochemical properties of exposure aerosols may help to understand the differential immunopathologic mechanisms of sensitization and CBD and lead to more biologically relevant exposure standards. Properties of aerosols generated during the industrial milling of bertrandite and beryl ores were evaluated. Airborne beryllium mass concentrations among work areas ranged from 0.001 kg/m super(3) (beryl ore grinding) to 2.1 kg/m super(3) (beryl ore crushing). Respirable mass fractions of airborne beryllium-containing particles were  80% in high-energy input areas (beryl melting, beryl grinding). Particle specific surface area decreased with processing from feedstock ores to drumming final product beryllium hydroxide. Among work areas, beryllium was identified in three crystalline forms: beryl, poorly crystalline beryllium oxide, and beryllium hydroxide. In comparison to aerosols generated by high-CBD risk primary production processes, aerosol particles encountered during milling had similar mass concentrations, generally lower number concentrations and surface area, and contained no identifiable highly crystalline beryllium oxide. One possible explanation for the apparent low prevalence of CBD among workers exposed to beryllium mineral dusts may be that characteristics of the exposure material do not contribute to the development of lung burdens sufficient for progression from sensitization to CBD. In comparison to high-CBD risk exposures where the chemical nature of aerosol particles may confer higher bioavailability, respirable ore dusts likely confer considerably less. While finished product beryllium hydroxide particles may confer bioavailability similar to that of high-CBD risk aerosols, physical exposure factors (i.e., large particle sizes) may limit development of alveolar lung burdens.
JF  - Journal of Toxicology and Environmental Health, Part A: Current Issues
AU  - Stefaniak, AB
AU  - Chipera, S J
AU  - Day, G A
AU  - Sabey, P
AU  - Dickerson, R M
AU  - Sbarra, D C
AU  - Duling, M G
AU  - Lawrence, R B
AU  - Stanton, M L
AU  - Scripsick, R C
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, AStefaniak@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 1468
EP  - 1481
VL  - 71
IS  - 21
SN  - 1528-7394, 1528-7394
KW  - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; Risk Abstracts; Environment Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts
KW  - Inhalation
KW  - Risk assessment
KW  - Aerosol particles
KW  - Heavy metals
KW  - Particulates
KW  - Primary production
KW  - Dust
KW  - Melting
KW  - Bioavailability
KW  - Ores
KW  - Risk factors
KW  - Alloys
KW  - oxides
KW  - alloys
KW  - Occupational exposure
KW  - Berylliosis
KW  - Metals
KW  - Aerosols
KW  - Surface area
KW  - Physicochemical properties
KW  - Silicic acid
KW  - Alveoli
KW  - hydroxides
KW  - Ceramics
KW  - Lung
KW  - Beryllium
KW  - Drumming
KW  - Minerals
KW  - surface area
KW  - R2 23080:Industrial and labor
KW  - M2 551.510.42:Air Pollution (551.510.42)
KW  - H 1000:Occupational Safety and Health
KW  - X 24360:Metals
KW  - P 6000:TOXICOLOGY AND HEALTH
KW  - ENA 02:Toxicology & Environmental Safety
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Risk assessment; Berylliosis; Inhalation; Aerosols; Heavy metals; Surface area; Silicic acid; Physicochemical properties; Primary production; Dust; Alveoli; Ceramics; Melting; Bioavailability; Ores; Lung; Risk factors; Beryllium; Drumming; oxides; alloys; Minerals; Occupational exposure; Aerosol particles; Metals; Particulates; hydroxides; Alloys; surface area
DO  - http://dx.doi.org/10.1080/15287390802349883
ER  - 



TY  - JOUR
T1  - Hydrophilic Fungi and Ergosterol Associated with Respiratory Illness in a Water-Damaged Building
AN  - 20197925; 8044956
AB  - Background: Damp building-related respiratory illnesses are an important public health issue. Objective: We compared three respiratory case groups defined by questionnaire responses [200 respiratory cases, 123 of the respiratory cases who met the epidemiologic asthma definition, and 49 of the epidemiologic asthma cases who had current physician-diagnosed asthma with post-occupancy onset] to a comparison group of 152 asymptomatic employees in an office building with a history of water damage. Methods: We analyzed dust samples collected from floors and chairs of 323 cases and comparisons for culturable fungi, ergosterol, endotoxin, and cat and dog allergens. We examined associations of total fungi, hydrophilic fungi (requiring water activity greater than or equal to 0.9), and ergosterol with the health outcomes using logistic regression models. Results: In models adjusted for demographics, respiratory illnesses showed significant linear exposure-response relationships to total culturable fungi [interquartile range odds ratios (IQR-OR) = 1.37-1.72], hydrophilic fungi (IQR-OR = 1.45-2.19), and ergosterol (IQR-OR = 1.54-1.60) in floor and chair dusts. Of three outcomes analyzed, current asthma with postoccupancy physician diagnosis was most strongly associated with exposure to hydrophilic fungi in models adjusted for ergosterol, endotoxin, and demographics (IQR-OR = 2.09 for floor and 1.79 for chair dusts). Ergosterol levels in floor dust were significantly associated with epidemiologic asthma independent of culturable fungi (IQR-OR = 1.54-1.55). Conclusions: Our findings extend the 2004 conclusions of the Institute of Medicine [Human health effects associated with damp indoor environments. In: Damp Indoor Spaces and Health. Washington DC:National Academies Press, 183-269] by showing that mold levels in dust were associated with new-onset asthma in this damp indoor environment Hydrophilic fungi and ergosterol as measures of fungal biomass may have promise as markers of risk of building-related respiratory diseases in damp indoor environments.
JF  - Environmental Health Perspectives
AU  - Park, J-H
AU  - Cox-Ganser, J M
AU  - Kreiss, K
AU  - White, S K
AU  - Rao, CY
AD  - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, MS 2800, 1095 Willowdale Rd., Morgantown, WV 26505 USA, gzp8@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 45
EP  - 50
VL  - 116
IS  - 1
SN  - 0091-6765, 0091-6765
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts
KW  - demography
KW  - Endotoxins
KW  - Historical account
KW  - Water activity
KW  - Molds
KW  - Respiratory diseases
KW  - Dust
KW  - Public health
KW  - Models
KW  - Demography
KW  - USA, Washington
KW  - Dose-response effects
KW  - Allergens
KW  - Water-borne diseases
KW  - Regression analysis
KW  - Inventories
KW  - Fungi
KW  - Asthma
KW  - Biomass
KW  - Indoor environments
KW  - Ergosterol
KW  - K 03410:Animal Diseases
KW  - X 24370:Natural Toxins
KW  - A 01490:Miscellaneous
KW  - R2 23060:Medical and environmental health
KW  - H 12000:Epidemiology and Public Health
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-03-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Endotoxins; Inventories; Fungi; Water activity; Asthma; Molds; Biomass; Dust; Models; Public health; Demography; Allergens; Dose-response effects; Regression analysis; Ergosterol; demography; Historical account; Water-borne diseases; Respiratory diseases; Indoor environments; USA, Washington
DO  - http://dx.doi.org/10.1289/ehp.10355
ER  - 



TY  - JOUR
T1  - Process analytical technology: Non-destructive assessment of anastrozole entrapment within PLGA microparticles by near infrared spectroscopy and chemical imaging
AN  - 20064105; 10062988
AB  - The objective of this study was to evaluate near-infrared (NIR) spectroscopy and imaging as approaches to assess anastrozole entrapment within PLGA microparticles. By varying the polymer concentration, three batches containing the same amount of the drug were prepared. The spectral features that allow NIR drug quantitation were evaluated and compared with a best fit line algorithm. Actual entrapment efficiencies (EEF) determined via a destructive method were used for construction of calibration models using partial least square regression (PLS) or the algorithm. On the other hand, a chemical imaging system based on array detector technology was used to rapidly collect high contrast NIR images of the formulated microparticles. A quantitative measure of anastrozole entrapped was determined by calculating the percentage standard deviation of the distribution of pixel intensities in the PLS score images and histograms. Concerning conventional NIR analysis, both methods were equivalent for the prediction of EEF over the range of polymer levels studied. Correlation coefficients of more than 0.992 were obtained for either the calibration or prediction of EEF by the two methods; 0.392% and 0.374% were the standard errors of calibration and prediction (SEC and SEP) obtained for the prediction of EEF using the fit line, respectively, whereas the prediction of the EEF by the partial least square regression showed a SEC of 0.195% and SEP of 0.179%. As a result, the spectral best fit algorithm method compared favourably to the multivariate PLS method, but was easier to develop. In contrast, NIR spectral imaging was capable of clearly differentiating the three batches, both qualitatively and quantitatively. The percentage standard deviation increased progressively by increasing the ratio of drug-to-polymer concentrations. In conclusion, both NIR approaches were capable of accurate assessment of drug entrapment within microparticles. In addition, the NIR spectral imaging system provides a rapid approach for acquiring spatial and spectral information on microparticles.
JF  - Journal of Microencapsulation
AU  - Zidan, A S
AU  - Sammour, O A
AU  - Hammad, M A
AU  - Megrab, N A
AU  - Habib, M J
AU  - Khan, M A
AD  - Division of Product Quality Research, Food and Drug Administration, Maryland, USA
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 145
EP  - 153
PB  - Taylor & Francis, 1 Gunpowder Sq. London EC4A UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk]
VL  - 25
IS  - 3
SN  - 0265-2048, 0265-2048
KW  - Biotechnology and Bioengineering Abstracts
KW  - Anastrozole
KW  - I.R. radiation
KW  - microparticles
KW  - polylactide-co-glycolide
KW  - microencapsulation
KW  - Algorithms
KW  - spatial discrimination
KW  - Drug development
KW  - Drug screening
KW  - imaging
KW  - Standard deviation
KW  - I.R. spectroscopy
KW  - Regression analysis
KW  - Drugs
KW  - Quantitation
KW  - W 30945:Fermentation & Cell Culture
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microencapsulation&rft.atitle=Process+analytical+technology%3A+Non-destructive+assessment+of+anastrozole+entrapment+within+PLGA+microparticles+by+near+infrared+spectroscopy+and+chemical+imaging&rft.au=Zidan%2C+A+S%3BSammour%2C+O+A%3BHammad%2C+M+A%3BMegrab%2C+N+A%3BHabib%2C+M+J%3BKhan%2C+M+A&rft.aulast=Zidan&rft.aufirst=A&rft.date=2008-01-01&rft.volume=25&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microencapsulation&rft.issn=02652048&rft_id=info:doi/10.1080%2F02652040601034963
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-07-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - imaging; microparticles; Anastrozole; Algorithms; Standard deviation; polylactide-co-glycolide; I.R. spectroscopy; Drug development; spatial discrimination; Drug screening; Regression analysis; I.R. radiation; microencapsulation; Quantitation; Drugs
DO  - http://dx.doi.org/10.1080/02652040601034963
ER  - 



TY  - JOUR
T1  - Vancomycin-Resistant Lactococcus lactis 1A-1 Isolated from a Competitive Exclusion Product Transfers Vancomycin Resistance Genes to Staphylococcus aureus
AN  - 20051022; 8360124
AB  - A vancomycin-resistant Lactococcus lactis isolate 1A-1 from a competitive exclusion (CE) product contained plasmid-encoded vanA, B, C1, and C2/3 genes. The L. lactis 1A-1 conjugatively transferred the genes to Staphylococcus aureus in vitro. CE product bacteria may be reservoirs for dissemination of vanA, B, and C genes to the human gastrointestinal microbiota.
JF  - Open Food Science Journal
AU  - Wagner, RDoug
AU  - Kurniasih-Rubin, Dedeh
AU  - Johnson, Shemedia J
AD  - Division of Microbiology, National Center for Toxicological Research, HFT-250, 3900 NCTR Rd., Jefferson, AR 72022, USA
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 72
EP  - 76
PB  - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [URL:http://www.bentham.org]
VL  - 2
KW  - Genetics Abstracts; Microbiology Abstracts B: Bacteriology
KW  - Lactococcus lactis
KW  - Vancomycin
KW  - Staphylococcus aureus
KW  - J 02310:Genetics & Taxonomy
KW  - G 07770:Bacteria
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-09-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Vancomycin; Lactococcus lactis; Staphylococcus aureus
DO  - http://dx.doi.org/10.2174/1874256400802010072
ER  - 



TY  - JOUR
T1  - Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells
AN  - 19989349; 7944480
AB  - Kava (Piper methysticum) is a member of the pepper family and has been cultivated by South Pacific islanders for centuries and used as a social and ceremonial drink. Traditionally, kava extracts are prepared by grinding or chewing the rhizome and mixing with water and coconut milk. The active constituents of kava are a group of approximately 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements. In order to study the toxicity and mutagenicity, two commercial samples of kava, Kaviar and KavaPure, and the six pure kavalactones including both d-kawain and dl-kawain, were evaluated in L5178Y mouse lymphoma cells. Neither the kava samples nor the kavalactones induced a mutagenic response in the L5178Y mouse lymphoma mutation assay with the addition of human liver S9 activation.
JF  - Food and Chemical Toxicology
AU  - Whittaker, P
AU  - Clarke, J J
AU  - San, RHC
AU  - Betz, J M
AU  - Seifried, HE
AU  - de Jager, LS
AU  - Dunkel, V C
AD  - Food and Drug Administration, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, United States, paul.whittaker@fda.hhs.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 168
EP  - 174
PB  - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl]
VL  - 46
IS  - 1
SN  - 0278-6915, 0278-6915
KW  - Genetics Abstracts; Immunology Abstracts; Toxicology Abstracts
KW  - Shrubs
KW  - Mutagenicity
KW  - Chewing
KW  - Milk
KW  - Beverages
KW  - Anxiety
KW  - Rhizomes
KW  - Point mutation
KW  - Roots
KW  - Toxicity
KW  - Liver transplantation
KW  - Anxiolytics
KW  - Mammalian cells
KW  - Dietary supplements
KW  - Piper methysticum
KW  - Allografts
KW  - Liver
KW  - Lymphoma
KW  - F 06955:Immunomodulation & Immunopharmacology
KW  - G 07800:Plants and Algae
KW  - X 24320:Food Additives & Contaminants
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Shrubs; Mutagenicity; Beverages; Milk; Chewing; Anxiety; Rhizomes; Point mutation; Roots; Toxicity; Liver transplantation; Anxiolytics; Mammalian cells; Dietary supplements; Allografts; Liver; Lymphoma; Piper methysticum
DO  - http://dx.doi.org/10.1016/j.fct.2007.07.013
ER  - 



TY  - JOUR
T1  - A new classification system for bacterial Rieske non-heme iron aromatic ring-hydroxylating oxygenases
AN  - 19900746; 8522270
AB  - Background Rieske non-heme iron aromatic ring-hydroxylating oxygenases (RHOs) are multi-component enzyme systems that are remarkably diverse in bacteria isolated from diverse habitats. Since the first classification in 1990, there has been a need to devise a new classification scheme for these enzymes because many RHOs have been discovered, which do not belong to any group in the previous classification. Here, we present a scheme for classification of RHOs reflecting new sequence information and interactions between RHO enzyme components. Result We have analyzed a total of 130 RHO enzymes in which 25 well-characterized RHO enzymes were used as standards to test our hypothesis for the proposed classification system. From the sequence analysis of electron transport chain (ETC) components of the standard RHOs, we extracted classification keys that reflect not only the phylogenetic affiliation within each component but also relationship among components. Oxygenase components of standard RHOs were phylogenetically classified into 10 groups with the classification keys derived from ETC components. This phylogenetic classification scheme was converted to a new systematic classification consisting of 5 distinct types. The new classification system was statistically examined to justify its stability. Type I represents two-component RHO systems that consist of an oxygenase and an FNR sub(C)-type reductase. Type II contains other two-component RHO systems that consist of an oxygenase and an FNR sub(N)-type reductase. Type III represents a group of three-component RHO systems that consist of an oxygenase, a [2Fe-2S]-type ferredoxin and an FNR sub(N)-type reductase. Type IV represents another three-component systems that consist of oxygenase, [2Fe-2S]-type ferredoxin and GR-type reductase. Type V represents another different three-component systems that consist of an oxygenase, a [3Fe-4S]-type ferredoxin and a GR-type reductase. Conclusion The new classification system provides the following features. First, the new classification system analyzes RHO enzymes as a whole. RwithSecond, the new classification system is not static but responds dynamically to the growing pool of RHO enzymes. Third, our classification can be applied reliably to the classification of incomplete RHOs. Fourth, the classification has direct applicability to experimental work. Fifth, the system provides new insights into the evolution of RHO systems based on enzyme interaction.
JF  - BMC Biochemistry
AU  - Kweon, Ohgew
AU  - Kim, Seong-Jae
AU  - Baek, Songjoon
AU  - Chae, Jong-Chan
AU  - Adjei, Michael D
AU  - Baek, Dong-Heon
AU  - Kim, Young-Chang
AU  - Cerniglia, Carl E
AD  - Microbiology Division, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, USA, oh-gew.kweon@fda.hhs.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 11
PB  - BioMed Central Ltd., Middlesex House
VL  - 9
KW  - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - Phylogeny
KW  - Classification systems
KW  - Bacteria
KW  - Enzymes
KW  - Habitat
KW  - Ferredoxin
KW  - Keys
KW  - reductase
KW  - Classification
KW  - Iron
KW  - Oxygenase
KW  - Evolution
KW  - Aromatics
KW  - Electron transport chain
KW  - J 02310:Genetics & Taxonomy
KW  - A 01300:Methods
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Biochemistry&rft.atitle=A+new+classification+system+for+bacterial+Rieske+non-heme+iron+aromatic+ring-hydroxylating+oxygenases&rft.au=Kweon%2C+Ohgew%3BKim%2C+Seong-Jae%3BBaek%2C+Songjoon%3BChae%2C+Jong-Chan%3BAdjei%2C+Michael+D%3BBaek%2C+Dong-Heon%3BKim%2C+Young-Chang%3BCerniglia%2C+Carl+E&rft.aulast=Kweon&rft.aufirst=Ohgew&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=BMC+Biochemistry&rft.issn=1471-2091&rft_id=info:doi/10.1186%2F1471-2091-9-11
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Classification systems; Phylogeny; Enzymes; Habitat; Ferredoxin; Keys; reductase; Classification; Oxygenase; Iron; Aromatics; Evolution; Electron transport chain; Bacteria
DO  - http://dx.doi.org/10.1186/1471-2091-9-11
ER  - 



TY  - JOUR
T1  - An investigation of hand forces and postures for using selected mechanical pipettes
AN  - 19804331; 8549446
AB  - The present study evaluated thumb, hand forces, wrist, forearm and shoulder postures used for pipetting with three selected mechanical pipettes. Twelve pipette users in a large university health system participated in pipetting simulation in their own laboratories to investigate the effects of pipette type, body posture (standing/seated), sample volume (200/1000 is a subset of L) and pipetting task on the physical risk factors. The thumb and hand forces were measured with 19 Flexiforce(TM) sensors. Wrist and forearm postures were measured with an electrogoniometer and a torsiometer, respectively. Humeral elevation as shoulder postural stress was assessed by observations from videos recorded during pipetting simulation. The study results showed several advantages of using the non-axial pipette over the traditional axial ones. The non-axial pipette was associated with approximately 2-6 times less thumb and hand force than the traditional axial pipettes. In addition, there were approximately 20-30% reductions in ulnar deviation and 30-70% reductions in humeral elevation to operate the non-axial pipette for most of the pipetting actions. One disadvantage of using the non-axial pipette appears to be increased forearm pronation by approximately 100-150% for the entire pipetting cycle, as compared to the axial pipettes. The results of the study may provide useful information regarding design of pipettes for reducing physical risk factors associated with pipetting. Relevance to industry This paper demonstrated hand forces and postures for common pipetting tasks with selected mechanical pipettes. The hand force and postural data for using axial and non-axial pipettes may provide key information for hand injury prevention due to pipetting in the industry.
JF  - International Journal of Industrial Ergonomics
AU  - Lu, Ming-Lun
AU  - James, Tamara
AU  - Lowe, Brian
AU  - Barrero, Marisol
AU  - Kong, Yong-Ku
AD  - National Institute for Occupational Safety and Health, Taft Laboratories, 4676 Columbia Parkway MS C-24, Cincinnati, OH 45226, USA, mlu@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 18
EP  - 29
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 38
IS  - 1
SN  - 0169-8141, 0169-8141
KW  - Risk Abstracts; Health & Safety Science Abstracts
KW  - Sensors
KW  - Injuries
KW  - prevention
KW  - Ergonomics
KW  - Stress
KW  - Simulation
KW  - Working conditions
KW  - Occupational health
KW  - posture
KW  - R2 23080:Industrial and labor
KW  - H 10000:Ergonomics/Human Factors
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=An+investigation+of+hand+forces+and+postures+for+using+selected+mechanical+pipettes&rft.au=Lu%2C+Ming-Lun%3BJames%2C+Tamara%3BLowe%2C+Brian%3BBarrero%2C+Marisol%3BKong%2C+Yong-Ku&rft.aulast=Lu&rft.aufirst=Ming-Lun&rft.date=2008-01-01&rft.volume=38&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2007.08.006
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-11-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - posture; Occupational health; Working conditions; Simulation; prevention; Ergonomics; Stress; Injuries; Sensors
DO  - http://dx.doi.org/10.1016/j.ergon.2007.08.006
ER  - 



TY  - JOUR
T1  - Asthma arising in flavoring-exposed food production workers
AN  - 19803739; 8572082
AB  - Objectives: While working for a small family-owned popcorn popping company, all of the three non-smoking workers developed a respiratory disease. Because of the newly identified associations between the flavoring chemicals and bronchiolitis obliterans, the specifics of these cases and their exposures were investigated to add to the body of knowledge of flavoring-related lung disease. Materials and Methods: We obtained data on work processes as well as full-shift personal and area air samples for diacetyl, acetoin, 2-nonanone, acetaldehyde, and total volatile organic compounds. Air samples were collected on thermal desorption tubes for analysis by gas chromatography mass spectrometry. We also reviewed medical records and conducted interview with the workers. Results: Air samples representative of the exposures that exacerbated asthma symptoms in two workers contained many different aldehydes. The data from interview and medical records and the high resolution computed tomograms of the chest indicated the presence of occupational asthma in all the three workers and possible bronchiolitis obliterans in two of them. This case series emphasizes a need for exposure reduction and medical surveillance among workers exposed to flavoring chemicals, and provides evidence for an increased risk of occupational asthma, as well as bronchiolitis obliterans, in flavoring-exposed workers.
JF  - International Journal of Occupational Medicine and Environmental Health
AU  - Sahakian, N
AU  - Kullman, G
AU  - Lynch, D
AU  - Kreiss, K
AD  - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Suite H2800, Morgantown, West Virginia, USA, 26505, KKreiss@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 173
EP  - 177
VL  - 21
IS  - 2
SN  - 1232-1087, 1232-1087
KW  - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts
KW  - Chemicals
KW  - Food
KW  - Acetaldehyde
KW  - Mass spectrometry
KW  - Flavorings
KW  - Respiratory diseases
KW  - Chest
KW  - Mass spectroscopy
KW  - Workers
KW  - occupational diseases
KW  - Gas chromatography
KW  - Air sampling
KW  - bronchiolitis obliterans
KW  - Occupational exposure
KW  - Data processing
KW  - Desorption
KW  - Acetoin
KW  - medical records
KW  - Lung diseases
KW  - Asthma
KW  - Diacetyl
KW  - Lung
KW  - Reviews
KW  - volatile organic compounds
KW  - Aldehydes
KW  - Volatile organic compounds
KW  - R2 23080:Industrial and labor
KW  - X 24320:Food Additives & Contaminants
KW  - H 1000:Occupational Safety and Health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-11-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Desorption; Data processing; Acetoin; medical records; Acetaldehyde; Food; Lung diseases; Asthma; Flavorings; Chest; Diacetyl; Mass spectroscopy; Workers; Gas chromatography; Reviews; volatile organic compounds; bronchiolitis obliterans; Aldehydes; Occupational exposure; Chemicals; Mass spectrometry; Respiratory diseases; occupational diseases; Lung; Air sampling; Volatile organic compounds
DO  - http://dx.doi.org/10.2478/v10001-008-0019-1
ER  - 



TY  - JOUR
T1  - Oxidative and molecular interactions of multi-wall carbon nanotubes (MWCNT) in normal and malignant human mesothelial cells
AN  - 19792685; 8493289
AB  - Carbon nanotubes are new tools in industry and medicine with their potential applications in many uses. Multiwall carbon nanotubes (MWCNT) with their morphologic similarity to asbestos and wide commercial and biomedical applications necessitate these investigations. The present study investigated the biological reactivity of MWCNT in normal (NM) and malignant (MM) mesothelial cells. MWCNT containing low iron content generated only negligible amounts of reactive oxygen species with both cells. Exposure of both cell types to MWCNT caused cell death, cytotoxicity, DNA damage and apoptosis, which were greater in MM cells. Exposure of both cells to MWCNT caused a parallel activation of two important transcription factors, phosphorylation of H2AX, and PARP activation which were greater in NM cells. Phosphorylation of ERK1/2 and p38 was greater in MM cells than in NM cells. These findings demonstrate that MWCNT are biologically potent activators of molecular events in NM cells associated with mesothelioma development.
JF  - Nanotoxicology
AU  - Pacurari, M
AU  - Yin, X J
AU  - Ding, M
AU  - Leonard, S S
AU  - Schwegler-Berry, D
AU  - Ducatman, B S
AU  - Chirila, M
AU  - Endo, M
AU  - Castranova, V
AU  - Vallyathan, V
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 155
EP  - 170
VL  - 2
IS  - 3
SN  - 1743-5390, 1743-5390
KW  - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts
KW  - Asbestos
KW  - Apoptosis
KW  - Extracellular signal-regulated kinase
KW  - DNA damage
KW  - Cytotoxicity
KW  - Carbon
KW  - Reactive oxygen species
KW  - Phosphorylation
KW  - Poly(ADP-ribose) polymerase
KW  - Transcription factors
KW  - mesothelioma
KW  - nanotubes
KW  - Iron
KW  - N 14820:DNA Metabolism & Structure
KW  - X 24360:Metals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19792685?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Oxidative+and+molecular+interactions+of+multi-wall+carbon+nanotubes+%28MWCNT%29+in+normal+and+malignant+human+mesothelial+cells&rft.au=Pacurari%2C+M%3BYin%2C+X+J%3BDing%2C+M%3BLeonard%2C+S+S%3BSchwegler-Berry%2C+D%3BDucatman%2C+B+S%3BChirila%2C+M%3BEndo%2C+M%3BCastranova%2C+V%3BVallyathan%2C+V&rft.aulast=Pacurari&rft.aufirst=M&rft.date=2008-01-01&rft.volume=2&rft.issue=3&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.1080%2F17435390802318356
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-10-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Asbestos; Apoptosis; DNA damage; Extracellular signal-regulated kinase; Cytotoxicity; Carbon; Phosphorylation; Reactive oxygen species; Transcription factors; Poly(ADP-ribose) polymerase; nanotubes; mesothelioma; Iron
DO  - http://dx.doi.org/10.1080/17435390802318356
ER  - 



TY  - JOUR
T1  - The change in weight perception of weight status among the overweight: comparison of NHANES III (1988-1994) and 1999-2004 NHANES
AN  - 19725741; 9042745
AB  - Objectives This study seeks to determine whether perception of weight status among the overweight has changed with the increasing overweight/obesity prevalence. Methods The perception of weight status was compared between overweight participants (BMI between 25.0-29.9 kg/m super(2)) from NHANES III (1988-1994) and overweight participants from NHANES 1999-2004. Perception of weight status was assessed by asking participants to classify their weight as about the right weight, underweight or overweight. Comparisons were made across age groups, genders, race/ethnicities and various income levels. Results Fewer overweight people during the NHANES 1999-2004 survey perceived themselves as overweight when compared to overweight people during the NHANES III survey. The change in distortion between the survey periods was greatest among persons with lower income, males and African-Americans. Conclusion The increase in overweight/obesity between the survey years (NHANES III and NHANES 1999-2004 has been accompanied with fewer overweight people perceiving themselves as overweight.
JF  - International Journal of Behavioral Nutrition and Physical Activity
AU  - Johnson-Taylor, Wendy L
AU  - Fisher, Rachel A
AU  - Hubbard, Van S
AU  - Starke-Reed, Pamela
AU  - Eggers, Paul S
AD  - US Department of Health and Human Services, National Institutes of Health, Division of Nutrition Research Coordination, Bethesda, MD, USA, wj50v@nih.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 9
PB  - BioMed Central Ltd., Middlesex House
VL  - 5
SN  - 1479-5868, 1479-5868
KW  - Physical Education Index
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19725741?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.atitle=The+change+in+weight+perception+of+weight+status+among+the+overweight%3A+comparison+of+NHANES+III+%281988-1994%29+and+1999-2004+NHANES&rft.au=Johnson-Taylor%2C+Wendy+L%3BFisher%2C+Rachel+A%3BHubbard%2C+Van+S%3BStarke-Reed%2C+Pamela%3BEggers%2C+Paul+S&rft.aulast=Johnson-Taylor&rft.aufirst=Wendy&rft.date=2008-01-01&rft.volume=5&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.issn=14795868&rft_id=info:doi/10.1186%2F1479-5868-5-9
LA  - English
DB  - Physical Education Index
N1  - Date revised - 2009-04-01
N1  - Last updated - 2011-12-14
DO  - http://dx.doi.org/10.1186/1479-5868-5-9
ER  - 



TY  - JOUR
T1  - Racial/Ethnic Minority Children's Use of Psychiatric Emergency Care in California's Public Mental Health System
AN  - 19716016; 7932432
AB  - OBJECTIVES: We examined rates and intensity of crisis services use by race/ethnicity for 351174 children younger than 18 years who received specialty mental health care from California's 57 county public mental health systems between July 1998 and June 2001. METHODS: We used fixed-effects regression for a controlled assessment of racial/ethnic disparities in children's use of hospital-based services for the most serious mental health crises (crisis stabilization services) and community-based services for other crises (crisis intervention services). RESULTS: African American children were more likely than were White children to use both kinds of crisis care and made more visits to hospital-based crisis stabilization services after initial use. Asian American/Pacific Islander and American Indian/Alaska Native children were more likely than were White children to use hospital-based crisis stabilization services but, along with Latino children, made fewer hospital-based crisis stabilization visits after an initial visit. CONCLUSIONS: African American children used both kinds of crisis services more than did White children, and Asian Americans/Pacific Islander and American Indians/Alaska Native children visited only when they experienced the most disruptive and troubling kind of crises, and made nonrecurring visits.
JF  - American Journal of Public Health
AU  - Snowden, Lonnie R
AU  - Masland, Mary C
AU  - Libby, Anne M
AU  - Wallace, Neal
AU  - Fawley, Kya
AD  - Lonnie R. Snowden, Mary C. Masland, and Kya Fawley are with the Center for Mental Health Services Research, School of Social Welfare, University of California, Berkeley. Anne M. Libby is with the Department of Psychiatry, School of Medicine, University of Colorado, Denver, and Health Sciences Center, Denver. Neal Wallace is with the Mark O. Hatfield School of Government, Portland State University, Portland, Ore
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 118
EP  - 124
PB  - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA
VL  - 98
IS  - 1
SN  - 0090-0036, 0090-0036
KW  - Sustainability Science Abstracts
KW  - Health care
KW  - INE, USA, California
KW  - crisis intervention
KW  - INE, USA, Alaska
KW  - Children
KW  - community involvement
KW  - Ethnic groups
KW  - Public health
KW  - M3 1010:Issues in Sustainable Development
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19716016?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Racial%2FEthnic+Minority+Children%27s+Use+of+Psychiatric+Emergency+Care+in+California%27s+Public+Mental+Health+System&rft.au=Snowden%2C+Lonnie+R%3BMasland%2C+Mary+C%3BLibby%2C+Anne+M%3BWallace%2C+Neal%3BFawley%2C+Kya&rft.aulast=Snowden&rft.aufirst=Lonnie&rft.date=2008-01-01&rft.volume=98&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Health care; crisis intervention; Children; community involvement; Ethnic groups; Public health; INE, USA, California; INE, USA, Alaska
ER  - 



TY  - JOUR
T1  - Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections
AN  - 19715391; 8568580
AB  - Infections with antimicrobial-resistant bacteria are a great challenge in both human and veterinary medicine. The purpose of this study was to determine antimicrobial susceptibility of 106 strains of Pseudomonas aeruginosa isolated from dogs with otitis and pyoderma from 2003 to 2006 in the United States. Three antimicrobial panels, including 6 classes and 32 antimicrobial agents, were used. A wide range of susceptibility patterns were noted with some isolates being resistant to between 8 and 28 (mean 16) of the antimicrobials tested. Among the b-lactams, all isolates were resistant to ampicillin, cefoxitin, cefpodoxime, cephalothin and cefazolin followed by amoxicillin/clavulanic acid (99%), ceftiofur (97%), ceftriaxone (39%), cefotaxime (26%), and cefotaxime/clavulanic acid (20%), whereas less than 7% of isolates were resistant to ceftazidime/clavulanic acid, ceftazidime, piperacillin/tazobactam or cefepime. Two isolates were resistant to the carbapenems. Among the quinolones and fluoroquinolones, the most isolates were resistant to naladixic acid (96%), followed by orbifloxacin (52%), difloxacin (43%), enrofloxacin (31%), marbofloxacin (27%), gatifloxacin (23%), levofloxacin (21%), and ciprofloxacin (16%). Among the aminoglycosides, the most resistance was seen to kanamycin (90%), followed by streptomycin (69%), gentamicin (7%), and amikacin (3%). Of the remaining antimicrobials 100% of the isolates were resistant to chloramphenicol followed by tetracycline (98%), trimethoprim/sulfamethoxazole (57%), and sulfisoxazole (51%). Point mutations were present in gyrA, gyrB, parC, and/or parE genes among 34 of the 102 naladixic acid-resistant isolates. Two isolates contained class 1 integrons carrying aadA gene conferring streptomycin and spectinomycin resistance. The findings suggest that many antimicrobial agents commonly used in companion animals may not constitute appropriate therapy for canine pseudomonas infections.
JF  - Veterinary Microbiology
AU  - Rubin, J
AU  - Walker, R D
AU  - Blickenstaff, K
AU  - Bodeis-Jones, S
AU  - Zhao, S
AD  - Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon S7N 5B4, Canada, shaohua.zhao@FDA.HHS.GOV
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 164
EP  - 172
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 131
IS  - 1-2
SN  - 0378-1135, 0378-1135
KW  - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology
KW  - Pseudomonas aeruginosa
KW  - Antimicrobial resistance
KW  - Fluoroquinolones
KW  - Canine
KW  - Class 1 integron
KW  - QRDR
KW  - Trimethoprim
KW  - Amikacin
KW  - Difloxacin
KW  - Drug resistance
KW  - Levofloxacin
KW  - Quinolones
KW  - Streptomycin
KW  - Infection
KW  - Cefpodoxime
KW  - DNA topoisomerase IV
KW  - Ceftazidime
KW  - Ciprofloxacin
KW  - Clavulanic acid
KW  - Pyoderma
KW  - Cefoxitin
KW  - Chloramphenicol
KW  - Cefotaxime
KW  - Sulfamethoxazole
KW  - DNA topoisomerase
KW  - b-Lactam antibiotics
KW  - Tazobactam
KW  - Ceftriaxone
KW  - Antimicrobial agents
KW  - Gatifloxacin
KW  - Gentamicin
KW  - Cefazolin
KW  - Otitis
KW  - Spectinomycin
KW  - Piperacillin
KW  - J 02410:Animal Diseases
KW  - A 01340:Antibiotics & Antimicrobials
KW  - G 07770:Bacteria
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-11-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Trimethoprim; Difloxacin; Amikacin; Levofloxacin; Drug resistance; Quinolones; Streptomycin; Infection; Cefpodoxime; DNA topoisomerase IV; Ceftazidime; Ciprofloxacin; Clavulanic acid; Pyoderma; Cefoxitin; Chloramphenicol; Cefotaxime; Sulfamethoxazole; Fluoroquinolones; b-Lactam antibiotics; DNA topoisomerase; Tazobactam; Ceftriaxone; Gatifloxacin; Antimicrobial agents; Gentamicin; Cefazolin; Otitis; Spectinomycin; Piperacillin; Pseudomonas aeruginosa
DO  - http://dx.doi.org/10.1016/j.vetmic.2008.02.018
ER  - 



TY  - JOUR
T1  - Analysis of musculoskeletal loading in an index finger during tapping
AN  - 19636099; 8793087
AB  - Since musculoskeletal disorders of the upper extremities are believed to be associated with repetitive excessive muscle force production in the hands, understanding the time-dependent muscle forces during key tapping is essential for exploring the mechanisms of disease initiation and development. In the current study, we have simulated the time-dependent dynamic loading in the muscle/tendons in an index finger during tapping. The index finger model is developed using a commercial software package AnyBody, and it contains seven muscle/tendons that connect the three phalangeal finger sections. Our simulations indicate that the ratios of the maximal forces in flexor digitorum superficialis (FS) and flexor digitorum profundus (FP) tendons to the maximal force at the fingertip are 0.95 and 2.9, respectively, which agree well with recently published experimental data. The time sequence of the finger muscle activation predicted in the current study is consistent with the EMG data in the literature. The proposed model will be useful for bioengineers and ergonomic designers to improve keyboard design minimizing musculoskeletal loadings in the fingers.
JF  - Journal of Biomechanics
AU  - Wu, John Z
AU  - An, Kai-Nan
AU  - Cutlip, Robert G
AU  - Krajnak, Kristine
AU  - Welcome, Daniel
AU  - Dong, Ren G
AD  - National Institute for Occupational Safety and Health, NIOSH/CDC, 1095 Willowdale Road, MS-2027, Morgantown, WV 26505, USA, jwu@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 668
EP  - 676
PB  - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl]
VL  - 41
IS  - 3
SN  - 0021-9290, 0021-9290
KW  - Health & Safety Science Abstracts
KW  - Index finger
KW  - Muscle force
KW  - Muscle-tendon excursion
KW  - Tapping
KW  - Simulations
KW  - biomechanics
KW  - Muscles
KW  - Simulation
KW  - musculoskeletal system
KW  - Ergonomics
KW  - H 10000:Ergonomics/Human Factors
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19636099?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Analysis+of+musculoskeletal+loading+in+an+index+finger+during+tapping&rft.au=Wu%2C+John+Z%3BAn%2C+Kai-Nan%3BCutlip%2C+Robert+G%3BKrajnak%2C+Kristine%3BWelcome%2C+Daniel%3BDong%2C+Ren+G&rft.aulast=Wu&rft.aufirst=John&rft.date=2008-01-01&rft.volume=41&rft.issue=3&rft.spage=668&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/10.1016%2Fj.jbiomech.2007.09.025
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - biomechanics; Muscles; Simulation; Ergonomics; musculoskeletal system
DO  - http://dx.doi.org/10.1016/j.jbiomech.2007.09.025
ER  - 



TY  - JOUR
T1  - Tracking the prevalence of rollover protective structures on U.S. farm tractors: 1993, 2001, and 2004
AN  - 19626810; 8770130
AB  - Problem - Between 1992 and 2005, 1412 workers on farms died from tractor overturns. A Rollover Protective Structure (ROPS) is a proven intervention to reduce overturn deaths. However, farm characteristics that are associated with the adoption of ROPS are not well understood. Methods - ROPS prevalence statistics were derived from National Institute for Occupational Safety and Health (NIOSH) surveys that tracked ROPS use on farms. Data were from the years 1993, 2001, and 2004. Results - In 1993, 38% of tractors were equipped with ROPS. This increased to 51% by 2004. ROPS prevalence rates were higher on farms in the Southern region of the United States, on farms where the operator was 25-34 years old, and on farms with $100,000 or more of farm sales. Low ROPS prevalence rates were associated with farm operators 65 years old or older and with farms with less than $10,000 of farm product sales. Summary - The increase in ROPS prevalence between 1993 and 2004 has not been sufficient to decrease the rate of tractor overturn deaths on farms. Incentive programs targeting older farm operators and low-income farm operations are suggested to increase ROPS use on tractors. Impact on Industry - The study provides farm characteristics associated with low ROPS prevalence rates. The results can be used to target farms for future ROPS promotion activities.
JF  - Journal of Safety Research
AU  - Loringer, Kelly A
AU  - Myers, John R
AD  - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA, JrMyers@cdc.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 509
EP  - 517
PB  - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl]
VL  - 39
IS  - 5
SN  - 0022-4375, 0022-4375
KW  - Risk Abstracts; Health & Safety Science Abstracts
KW  - Occupational safety
KW  - Socioeconomics
KW  - intervention
KW  - farms
KW  - rollover
KW  - Mortality
KW  - USA
KW  - R2 23080:Industrial and labor
KW  - H 1000:Occupational Safety and Health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19626810?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Tracking+the+prevalence+of+rollover+protective+structures+on+U.S.+farm+tractors%3A+1993%2C+2001%2C+and+2004&rft.au=Loringer%2C+Kelly+A%3BMyers%2C+John+R&rft.aulast=Loringer&rft.aufirst=Kelly&rft.date=2008-01-01&rft.volume=39&rft.issue=5&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.08.003
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-01-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - USA; farms; Mortality; rollover; Socioeconomics; Occupational safety; intervention
DO  - http://dx.doi.org/10.1016/j.jsr.2008.08.003
ER  - 



TY  - JOUR
T1  - Childhood overweight and obesity: is the gap closing the wrong way?
AN  - 19602419; 8201788
AB  - BACKGROUND: Obesity is a significant public health issue. Obese children have an increased risk of developing chronic adult diseases. Knowledge of socio-economic distribution trends in childhood overweight/obesity is limited. METHODS: Body mass indices for 3-year-old children resident in three South Wales localities from 1995 to 2005 were derived from the National Community Child Health Database (NCCHD) and examined in relation to residence lower super output area (LSOA) Townsend Material Deprivation Score. RESULTS: Over 11 years, 53-69% of children had height/weight measurements recorded (with little difference observed across deprivation fifths). Amalgamating the data for all 11 years showed no significant association of prevalence with LSOA socio-economic status. Annual trends varied substantially: the most deprived fifth had the lowest proportion on five, and the highest on six, occasions. Linear regression analysis suggested a greater rate of increase of overweight/obesity in children from most-deprived LSOA areas compared with those from least deprived areas (not statistically significant). CONCLUSIONS: Socio-economic difference in overweight/obesity prevalence lessened between 1995 and 2005. Despite annual variation, this apparent closing of the gap has been the result of an increase in overweight/obesity prevalence in children from the most deprived areas who, initially, had a lower prevalence compared with children from least deprived areas, but by 2005, had overtaken them.
JF  - Journal of Public Health Medicine
AU  - Brunt, H
AU  - Lester, N
AU  - Davies, G
AU  - Williams, R
AD  - National Public Health Service for Wales, St. David's Park, Job's Well Road, Carmarthen SA31 3WY, UK
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 145
EP  - 152
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 30
IS  - 2
SN  - 0957-4832, 0957-4832
KW  - Risk Abstracts; Health & Safety Science Abstracts
KW  - obesity
KW  - Socioeconomics
KW  - Public health
KW  - body mass
KW  - British Isles, Wales, South Wales
KW  - annual variations
KW  - Children
KW  - R2 23060:Medical and environmental health
KW  - H 12000:Epidemiology and Public Health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602419?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health+Medicine&rft.atitle=Childhood+overweight+and+obesity%3A+is+the+gap+closing+the+wrong+way%3F&rft.au=Brunt%2C+H%3BLester%2C+N%3BDavies%2C+G%3BWilliams%2C+R&rft.aulast=Brunt&rft.aufirst=H&rft.date=2008-01-01&rft.volume=30&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health+Medicine&rft.issn=09574832&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - British Isles, Wales, South Wales; obesity; Children; Socioeconomics; Public health; annual variations; body mass
ER  - 



TY  - JOUR
T1  - Issues When Modeling Benzene, Toluene, and Xylene Exposures Using a Literature Database
AN  - 19539753; 8502026
AB  - A database of benzene, toluene, and xylene measurements was compiled from an extensive literature review that contained information on several exposure determinants, including job type, operation, mechanism of release, process type, ventilation, temperature, distance from the source, quantity, and location. The database was used to develop statistical models for benzene, toluene, and xylene exposure as a function of operation and other workplace determinants. These models can be used to predict exposure levels for subjects enrolled in community-based case-control studies. This article presents the derived parameter estimates for specific operations and additional workplace exposure determinants and describes a number of statistical and data limitation issues that are inherent in determinants modeling of historical published data. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resource(s): a PDF file of QQ plots and a Word file with references used in the benzene/toluene/xylene exposure database.]
JF  - Journal of Occupational and Environmental Hygiene
AU  - Hein, Misty J
AU  - Waters, Martha A
AU  - van Wijngaarden, Edwin
AU  - Deddens, James A
AU  - Stewart, Patricia A
AD  - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 36
EP  - 47
PB  - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk]
VL  - 5
IS  - 1
SN  - 1545-9624, 1545-9624
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - Historical account
KW  - Statistics
KW  - Ventilation
KW  - Toluene
KW  - Statistical analysis
KW  - Benzene
KW  - Models
KW  - Xylene
KW  - Occupational exposure
KW  - Environmental hygiene
KW  - Temperature effects
KW  - Data processing
KW  - Mathematical models
KW  - Temperature
KW  - community involvement
KW  - Databases
KW  - Reviews
KW  - Hygiene
KW  - H 1000:Occupational Safety and Health
KW  - X 24350:Industrial Chemicals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19539753?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Issues+When+Modeling+Benzene%2C+Toluene%2C+and+Xylene+Exposures+Using+a+Literature+Database&rft.au=Hein%2C+Misty+J%3BWaters%2C+Martha+A%3Bvan+Wijngaarden%2C+Edwin%3BDeddens%2C+James+A%3BStewart%2C+Patricia+A&rft.aulast=Hein&rft.aufirst=Misty&rft.date=2008-01-01&rft.volume=5&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701763947
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-11-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Temperature effects; Mathematical models; Data processing; Statistics; Ventilation; Toluene; Statistical analysis; Benzene; Models; Databases; Xylene; Reviews; Occupational exposure; Environmental hygiene; Historical account; Temperature; Hygiene; community involvement
DO  - http://dx.doi.org/10.1080/15459620701763947
ER  - 



TY  - JOUR
T1  - Hearing Difficulty Attributable to Employment by Industry and Occupation: An Analysis of the National Health Interview Survey-- United States, 1997 to 2003
AN  - 19528901; 8113439
AB  - Objective: To estimate the national burden of hearing difficulty among workers in US industries and occupations. Methods: Data on 130,102 employed National Health Interview Survey respondents between the ages of 18 to 65 years who were interviewed between 1997 and 2003 were analyzed to estimate the population prevalence, adjusted prevalence ratios, and fractions of hearing difficulty attributable to employment. Results: The estimated population prevalence of hearing difficulty was 11.4% (24% attributable to employment). The adjusted prevalence ratios of hearing difficulty were highest for railroads, mining, and primary metal manufacturing industry. Occupations with increased risk of hearing difficulty were mechanics/repairers, machine operators, and transportation equipment operators. Conclusions: Hearing difficulty was differentially distributed across various industries. In industries with high rates, employers and workers should take preventive action to reduce the risk of occupational hearing loss.
JF  - Journal of Occupational and Environmental Medicine
AU  - Tak, S
AU  - Calvert, G M
AD  - Surveillance Branch, Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-17, Cincinnati, OH 45226, USA, stak@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 46
EP  - 56
VL  - 50
IS  - 1
SN  - 1076-2752, 1076-2752
KW  - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts
KW  - risk reduction
KW  - Transportation
KW  - Railroads
KW  - Metals
KW  - Noise levels
KW  - Hearing loss
KW  - Mining
KW  - Manufacturing industry
KW  - Age
KW  - Occupational exposure
KW  - USA
KW  - R2 23080:Industrial and labor
KW  - P 7000:NOISE
KW  - H 1000:Occupational Safety and Health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19528901?accountid=14244
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - USA; Hearing loss; risk reduction; Railroads; Metals; Noise levels; Occupational exposure; Transportation; Manufacturing industry; Mining; Age
DO  - http://dx.doi.org/10.1097/JOM.0b013e3181579316
ER  - 



TY  - JOUR
T1  - Antimicrobial Resistance Genes Associated with Salmonella enterica Serovar Newport Isolates from Food Animals
AN  - 19526802; 7932106
AB  - Salmonella enterica serotype Newport is an important cause of salmonellosis, with strains increasingly being resistant to multiple antimicrobial agents. The increase is associated with the acquisition of multiple resistance genes. This study characterizes the genetic basis of resistance of serotype Newport isolates collected from veterinary sources by PCR and DNA sequencing analysis.
JF  - Antimicrobial Agents & Chemotherapy
AU  - Lynne, Aaron M
AU  - Rhodes-Clark, Bobbie S
AU  - Bliven, Kimberly
AU  - Zhao, Shaohua
AU  - Foley, Steven L
AD  - National Farm Medicine Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449. Department of Biology, University of Central Arkansas, Conway, Arkansas 72035. Division of Animal and Food Microbiology, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 353
EP  - 356
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 52
IS  - 1
SN  - 0066-4804, 0066-4804
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts B: Bacteriology
KW  - DNA sequencing
KW  - Serotypes
KW  - Salmonella enterica
KW  - Drug resistance
KW  - Food
KW  - Salmonellosis
KW  - Polymerase chain reaction
KW  - Antimicrobial agents
KW  - J 02310:Genetics & Taxonomy
KW  - A 01340:Antibiotics & Antimicrobials
KW  - G 07770:Bacteria
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19526802?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Antimicrobial+Resistance+Genes+Associated+with+Salmonella+enterica+Serovar+Newport+Isolates+from+Food+Animals&rft.au=Lynne%2C+Aaron+M%3BRhodes-Clark%2C+Bobbie+S%3BBliven%2C+Kimberly%3BZhao%2C+Shaohua%3BFoley%2C+Steven+L&rft.aulast=Lynne&rft.aufirst=Aaron&rft.date=2008-01-01&rft.volume=52&rft.issue=1&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - DNA sequencing; Serotypes; Salmonellosis; Food; Drug resistance; Polymerase chain reaction; Antimicrobial agents; Salmonella enterica
ER  - 



TY  - JOUR
T1  - The suicide mortality of working physicians and dentists
AN  - 19522441; 7936933
AB  - BACKGROUND: Some studies have shown that physicians and dentists have elevated risks of suicide, while other studies have not. Aims Using all deaths and corresponding census data in 26 US states, we examine the suicide risk for working physicians and dentists. METHODS: Death and census data for working people were obtained from 1984 through 1992. Directly age-standardized suicide rate ratios (SRRs) were calculated for white male and white female physicians and white male dentists. RESULTS: For white female physicians, the suicide rate was elevated compared to the working US population (SRR = 2.39, 95% CI = 1.52-3.77). For white male physicians and dentists, the overall suicide rates were reduced (SRR = 0.80, 95% CI = 0.53-1.20 and 0.68, 95% CI = 0.52-0.89, respectively). For older white male physicians and dentists, however, observed suicide rates were elevated. CONCLUSIONS: White female physicians have an elevated suicide rate. Only older white male physicians and dentists have elevated suicide rates, which partially explains the varied conclusions in the literature.
JF  - Occupational Medicine
AU  - Petersen, Martin R
AU  - Burnett, Carol A
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 25
EP  - 29
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 58
IS  - 1
SN  - 0962-7480, 0962-7480
KW  - Risk Abstracts; Health & Safety Science Abstracts
KW  - census
KW  - Mortality
KW  - suicide
KW  - Working conditions
KW  - Occupational health
KW  - R2 23080:Industrial and labor
KW  - H 1000:Occupational Safety and Health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19522441?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+Medicine&rft.atitle=The+suicide+mortality+of+working+physicians+and+dentists&rft.au=Petersen%2C+Martin+R%3BBurnett%2C+Carol+A&rft.aulast=Petersen&rft.aufirst=Martin&rft.date=2008-01-01&rft.volume=58&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Occupational+Medicine&rft.issn=09627480&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - census; Mortality; Working conditions; suicide; Occupational health
ER  - 



TY  - JOUR
T1  - In Vitro Evaluation of the Protective Role of Human Antibodies to West Nile Virus (WNV) Produced during Natural WNV Infection
AN  - 19488016; 8585599
AB  - Background. West Nile virus (WNV) is endemic in the United States and transmissible by transfusion. Since 2003, the US blood supply has been screened by nucleic-acid tests (NAT) for WNV in minipools (MP-NAT) of 6 or 16 specimens. WNV infection begins with low-level viremia detectable only by individual testing (ID-NAT) and no detectable WNV antibodies. Viremia then increases to levels detectable by MP-NAT, and antibodies become detectable; later, viremia decays to levels detectable only by ID-NAT before becoming undetectable. All but 1 documented WNV transmission by transfusion involved blood components negative for WNV antibodies, raising the question whether WNV antibody-positive blood components with low levels of WNV RNA are infectious. Methods. Specimens from 102 viremic donors with and without WNV antibodies were used to investigate infectivity in cultures of Vero cells and human monocyte-derived macrophages (MDMs). Results. In Vero cell culture, 54 (74%) of 73 WNV antibody-negative specimens and 10 (36%) of 28 WNV antibody- positive specimens were infectious. In a random subset of 20 specimens tested in MDM culture, 7 (88%) of 8 WNV antibody-positive specimens and 12 (100%) of 12 WNV antibody-negative specimens were infectious. Conclusion. WNV antibodies do not always protect susceptible cells from WNV infection in vitro. RNA positivity in the presence of antibody cannot be ignored as a theoretical risk for blood recipients and needs further investigation.
JF  - Journal of Infectious Diseases
AU  - Rios, M
AU  - Daniel, S
AU  - Dayton, AI
AU  - Wood, O
AU  - Hewlett, I K
AU  - Epstein, J S
AU  - Caglioti, S
AU  - Stramer, S L
AD  - Laboratory of Molecular Virology-Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, and American Red Cross, Gaithersburg, Maryland, Maria.Rios@fda.hhs.gov
Y1  - 2008///0,
PY  - 2008
DA  - 0, 2008
SP  - 1300
EP  - 1308
PB  - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu]
VL  - 198
IS  - 9
SN  - 0022-1899, 0022-1899
KW  - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts; Virology & AIDS Abstracts
KW  - Macrophages
KW  - Human diseases
KW  - Vero cells
KW  - Cell culture
KW  - Infection
KW  - Transfusion
KW  - Disease transmission
KW  - Public health
KW  - Blood
KW  - USA
KW  - Infectivity
KW  - Antibodies
KW  - Endemic species
KW  - RNA
KW  - Viral diseases
KW  - Infectious diseases
KW  - Viremia
KW  - Monocytes
KW  - West Nile virus
KW  - V 22350:Immunology
KW  - Q1 08484:Species interactions: parasites and diseases
KW  - F 06910:Microorganisms & Parasites
KW  - Q5 08524:Public health, medicines, dangerous organisms
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=In+Vitro+Evaluation+of+the+Protective+Role+of+Human+Antibodies+to+West+Nile+Virus+%28WNV%29+Produced+during+Natural+WNV+Infection&rft.au=Rios%2C+M%3BDaniel%2C+S%3BDayton%2C+AI%3BWood%2C+O%3BHewlett%2C+I+K%3BEpstein%2C+J+S%3BCaglioti%2C+S%3BStramer%2C+S+L&rft.aulast=Rios&rft.aufirst=M&rft.date=2008-01-01&rft.volume=198&rft.issue=9&rft.spage=1300&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F592277
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-11-01
N1  - Last updated - 2016-05-27
N1  - SubjectsTermNotLitGenreText - Macrophages; Endemic species; Human diseases; Antibodies; Infectious diseases; Viral diseases; Public health; Disease transmission; Blood; Infectivity; RNA; Vero cells; Cell culture; Monocytes; Viremia; Transfusion; Infection; West Nile virus; USA
DO  - http://dx.doi.org/10.1086/592277
ER  - 



TY  - JOUR
T1  - Compact and portable digitally controlled device for testing footwear materials: Technical note
AN  - 19425756; 8833338
AB  - Little or no practical decision-making data are available to the foot-care provider regarding the selection of orthotic materials used in therapeutic footwear. A device for simulating in-shoe forefoot conditions for the testing of ortho-sis materials is described. Materials are tested for their effectiveness by evaluating and comparing stress-strain and dynamic compression fatigue characteristics. The device, called the Cyclical Compression Tester (CCT), has been optimized for size, simplicity of construction, and cost. Application of the device ranges from the clinician deciding the useful life of single- and multidensity orthosis materials to the researcher characterizing materials for finite-element analysis modeling. This real-time CCT device and custom user interface combine to make an evaluation tool useful for testing how the pressure distribution of in-shoe materials changes over time in therapeutic footwear for those with peripheral neuropathy at risk for foot injury.
JF  - Journal of Rehabilitation Research and Development
AU  - Foto, J G
AD  - National Hansen's Disease Programs, Paul W. Brand Biomechanics Laboratory, 1770 Physicians Park Dr, Baton Rouge, LA 70816, USA, jfoto@hrsa.gov
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 893
EP  - 900
VL  - 45
IS  - 6
SN  - 0748-7711, 0748-7711
KW  - Physical Education Index
KW  - Evaluation
KW  - Fatigue
KW  - Feet
KW  - Injuries
KW  - Analysis
KW  - Stress
KW  - Orthotics
KW  - Shoes
KW  - Modeling
KW  - PE 110:Physical Therapy
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19425756?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Compact+and+portable+digitally+controlled+device+for+testing+footwear+materials%3A+Technical+note&rft.au=Foto%2C+J+G&rft.aulast=Foto&rft.aufirst=J&rft.date=2008-01-01&rft.volume=45&rft.issue=6&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2007.07.0111
LA  - English
DB  - Physical Education Index
N1  - Date revised - 2008-12-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Shoes; Orthotics; Modeling; Analysis; Evaluation; Feet; Fatigue; Stress; Injuries
DO  - http://dx.doi.org/10.1682/JRRD.2007.07.0111
ER  - 



TY  - JOUR
T1  - A new approach to characterize grip force applied to a cylindrical handle
AN  - 19419940; 8808321
AB  - The grip force applied to a cylindrical handle is a function of the measurement reference axis. So far, however, no attempt has been made to fully describe the exact form of this function. The objectives of this study were to examine some fundamental characteristics of grip forces and to explore the basic pattern of the grip force function. Twenty subjects (10 males and 10 females) participated in the experiment. The subjects alternately used their left and right hands to apply maximum grip forces and medium grip forces (about 40% of maximum) to a 30 mm handle. A flexible pressure sensor mat was used to measure the grip pressure. The pressure was integrated with respect to different measurement axes; this resulted in the grip force function. This study found that every gripping action produces maximum and minimum force axes; these axes are separated by about 90 degree . The maximum force is correlated with the minimum force, but the former is generally about 1.42 times the latter. The principal grip direction is about 78 degree from the z sub(h)-axis of the hand biodynamic coordinate system defined in ISO 8727 [ISO 8727. Mechanical vibration and shock - human exposure - biodynamic coordinate systems. Geneva, Switzerland: International Organization for Standardization; 1997]. More interestingly, each of the 160 sets of experimental data reasonably fit this study's proposed elliptical model. The implications of the findings are discussed.
JF  - Medical Engineering & Physics
AU  - Dong, Ren G
AU  - Wu, John Z
AU  - Welcome, Daniel E
AU  - McDowell, Thomas W
AD  - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, MS L-2027, WV 26505, USA, rkd6@cdc.gov
Y1  - 2008/01//
PY  - 2008
DA  - Jan 2008
SP  - 20
EP  - 33
PB  - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl]
VL  - 30
IS  - 1
SN  - 1350-4533, 1350-4533
KW  - Biotechnology and Bioengineering Abstracts
KW  - Vibrations
KW  - Standardization
KW  - Mathematical models
KW  - Data processing
KW  - Shock
KW  - Grasping
KW  - International organizations
KW  - Hand
KW  - Pressure
KW  - Models
KW  - W 30955:Biosensors
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19419940?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Engineering+%26+Physics&rft.atitle=A+new+approach+to+characterize+grip+force+applied+to+a+cylindrical+handle&rft.au=Dong%2C+Ren+G%3BWu%2C+John+Z%3BWelcome%2C+Daniel+E%3BMcDowell%2C+Thomas+W&rft.aulast=Dong&rft.aufirst=Ren&rft.date=2008-01-01&rft.volume=30&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Medical+Engineering+%26+Physics&rft.issn=13504533&rft_id=info:doi/10.1016%2Fj.medengphy.2007.01.002
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Grasping; Pressure; Hand; Vibrations; International organizations; Data processing; Models; Mathematical models; Shock; Standardization
DO  - http://dx.doi.org/10.1016/j.medengphy.2007.01.002
ER  - 



TY  - JOUR
T1  - Reduction of Fumonisin B sub(1) in Corn Grits by Single-Screw Extrusion
AN  - 19298428; 8133999
AB  - This study was designed to determine the efficacy of extrusion in reducing fumonisin B sub(1) in corn flaking grits in the presence and absence of glucose. In addition, degradation products of fumonisin B sub(1) during extrusion were identified and quantitated with a mass balance approach. Uncontaminated clean corn grits, grits spiked with 30 kg/g fumonisin B sub(1), and grits fermented with Fusarium verticillioides M-2552 (40-50 kg/g fumonisin B sub(1)) were extruded in the presence and absence of glucose (10%, w/w) using a single-screw extruder. Extrusion decreased fumonisin B sub(1) by 21-37%, whereas the same process with added glucose further decreased fumonisin B sub(1) by 77-87%. LC-fluorescence and LC-MS showed that most fumonisin in the extruded samples without added glucose was the fumonisin B sub(1) form, whereas the main degradation product in grits extruded with glucose was N-(deoxy-D-fructos-1-yl)fumonisin B sub(1). The formation of hydrolyzed fumonisin B sub(1) was not significant during extrusion. Results suggest that extrusion in the presence of glucose may reduce fumonisin B sub(1) in corn grits significantly. KW: Fumonisin; reduction; N-(deoxy-D- fructos-1-yl)fumonisin; extrusion.
JF  - Journal of Agricultural and Food Chemistry
AU  - Jablonski, Joseph
AU  - Jackson, Lauren S
AU  - Ryu, Dojin
AU  - Hanna, Milford A
AU  - Bianchini, Andreia
AU  - Bullerman, Lloyd B
AD  - Department of Food Science and Technology, 143 Filley Hall, University of Nebraska, Lincoln, Nebraska 68583; National Center for Food Safety and Technology, U.S. Food and Drug Administration, 6502 South Archer Road, Summit-Argo, Illinois 60501; and Department of Nutrition and Food Sciences, Texas Woman's University, P.O. Box 425888, Denton, Texas 76204
Y1  - 2008///0,
PY  - 2008
DA  - 0, 2008
SP  - 2400
EP  - 2405
PB  - American Chemical Society, [mailto:service@acs.org]
VL  - 56
IS  - 7
SN  - 0021-8561, 0021-8561
KW  - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - Glucose
KW  - Fumonisin B1
KW  - Fusarium verticillioides
KW  - Degradation products
KW  - A 01330:Food Microbiology
KW  - W 30935:Food Biotechnology
KW  - K 03420:Plant Diseases
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19298428?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+and+Food+Chemistry&rft.atitle=Reduction+of+Fumonisin+B+sub%281%29+in+Corn+Grits+by+Single-Screw+Extrusion&rft.au=Jablonski%2C+Joseph%3BJackson%2C+Lauren+S%3BRyu%2C+Dojin%3BHanna%2C+Milford+A%3BBianchini%2C+Andreia%3BBullerman%2C+Lloyd+B&rft.aulast=Jablonski&rft.aufirst=Joseph&rft.date=2008-01-01&rft.volume=56&rft.issue=7&rft.spage=2400&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+and+Food+Chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf0729513
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-09-01
N1  - Last updated - 2016-05-27
N1  - SubjectsTermNotLitGenreText - Glucose; Fumonisin B1; Degradation products; Fusarium verticillioides
DO  - http://dx.doi.org/10.1021/jf0729513
ER  - 



TY  - JOUR
T1  - Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells
AN  - 19288742; 8746616
AB  - Introduction Mesenchymal progenitor cells (MPCs) are multipotent progenitor cells in adult tissues, for example, bone marrow (BM). Current challenges of clinical application of BM-derived MPCs include donor site morbidity and pain as well as low cell yields associated with an age-related decrease in cell number and differentiation potential, underscoring the need to identify alternative sources of MPCs. Recently, MPC sources have diversified; examples include adipose, placenta, umbilicus, trabecular bone, cartilage, and synovial tissue. In the present work, we report the presence of MPCs in human tonsillar tissue. Methods We performed comparative and quantitative analyses of BM-MPCs with a subpopulation of adherent cells isolated from this lymphoid tissue, termed tonsil-derived MPCs (T-MPCs). The expression of surface markers was assessed by fluorescent-activated cell sorting analysis. Differentiation potential of T-MPCs was analyzed histochemically and by reverse transcription-polymerase chain reaction for the expression of lineage-related marker genes. The immunosuppressive properties of MPCs were determined in vitro in mixed lymphocyte reactions. Results Surface epitope analysis revealed that T-MPCs were negative for CD14, CD31, CD34, and CD45 expression and positive for CD29, CD44, CD90, and CD105 expression, a characteristic phenotype of BM-MPCs. Similar to BM-MPCs, T-MPCs could be induced to undergo adipogenic differentiation and, to a lesser extent, osteogenic and chondrogenic differentiation. T-MPCs did not express class II major histocompatibility (MHC) antigens, and in a similar but less pronounced manner compared with BM-MPCs, T-MPCs were immunosuppressive, inhibiting the proliferation of T cells stimulated by allogeneic T cells or by non-specific mitogenic stimuli via an indoleamine 2,3-dioxygenase-dependent mechanism.
JF  - Arthritis Research & Therapy
AU  - Janjanin, S
AU  - Djouad, F
AU  - Shanti, R M
AU  - Baksh, D
AU  - Gollapudi, K
AU  - Prgomet, D
AU  - Rackwitz, L
AU  - Joshi, A
AU  - Tuan, R S
AD  - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892, USA
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 1
VL  - 10
IS  - 4
SN  - 1478-6354, 1478-6354
KW  - Biotechnology and Bioengineering Abstracts
KW  - Mixed leukocyte reaction
KW  - Age
KW  - Cartilage
KW  - CD44 antigen
KW  - Bone marrow
KW  - Therapeutic applications
KW  - Major histocompatibility complex
KW  - Pain
KW  - CD14 antigen
KW  - Morbidity
KW  - Differentiation
KW  - Stem cells
KW  - Tonsil
KW  - Placenta
KW  - Lymphocytes T
KW  - Mesenchyme
KW  - Epitopes
KW  - CD105 antigen
KW  - Cell number
KW  - CD45 antigen
KW  - CD34 antigen
KW  - Umbilicus
KW  - Lymphoid tissue
KW  - Bone (trabecular)
KW  - CD90 antigen
KW  - CD29 antigen
KW  - Cell proliferation
KW  - Surface markers
KW  - Adherent cells
KW  - W 30920:Tissue Engineering
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=Human+palatine+tonsil%3A+a+new+potential+tissue+source+of+multipotent+mesenchymal+progenitor+cells&rft.au=Janjanin%2C+S%3BDjouad%2C+F%3BShanti%2C+R+M%3BBaksh%2C+D%3BGollapudi%2C+K%3BPrgomet%2C+D%3BRackwitz%2C+L%3BJoshi%2C+A%3BTuan%2C+R+S&rft.aulast=Janjanin&rft.aufirst=S&rft.date=2008-01-01&rft.volume=10&rft.issue=4&rft.spage=R83&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2459
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Tonsil; Major histocompatibility complex; Lymphocytes T; Mesenchyme; Bone (trabecular); CD105 antigen; Bone marrow; CD45 antigen; Mixed leukocyte reaction; Cell proliferation; CD34 antigen; CD90 antigen; Cell number; Epitopes; CD14 antigen; Therapeutic applications; Adherent cells; Placenta; Morbidity; Umbilicus; CD44 antigen; Age; CD29 antigen; Surface markers; Lymphoid tissue; Pain; Cartilage
DO  - http://dx.doi.org/10.1186/ar2459
ER  - 



TY  - JOUR
T1  - Incidence and Completeness of Notification of Legionnaires' Disease in the Netherlands: Covariate Capture-Recapture Analysis Acknowledging Regional Differences
AN  - 1667004777; 8189604
AB  - To estimate incidence and completeness of notification of Legionnaires' disease (LD) in The Netherlands in 2000 and 2001, we performed a capture- recapture analysis using three registers: Notifications, Laboratory results and Hospital admissions. After record-linkage, 373 of the 780 LD patients identified were notified. Ascertained under-notification was 52 super(.)2%. Because of expected and observed regional differences in the incidence rate of LD, alternatively to conventional log-linear capture-recapture models, a covariate (region) capture-recapture model, not previously used for estimating infectious disease incidence, was specified and estimated 886 LD patients (95% confidence interval 827-1022). Estimated under-notification was 57 super(.)9%. Notified, ascertained and estimated average annual incidence rates of LD were 1 super(.)15, 2 super(.)42 and 2 super(.)77/100 000 inhabitants respectively, with the highest incidence in the southern region of The Netherlands. Covariate capture-recapture analysis acknowledging regional differences of LD incidence appears to reduce bias in the estimated national incidence rate.
JF  - Epidemiology and Infection
AU  - Van Hest, NAH
AU  - Hoebe, CJPA
AU  - Boer, JWDen
AU  - Vermunt, J K
AU  - Ijzerman, EPF
AU  - Boersma, W G
AU  - Richardus, J H
AD  - Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands, vanhestr@ggd.rotterdam.nl
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 540
EP  - 550
PB  - Cambridge University Press, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org]
VL  - 136
IS  - 4
SN  - 0950-2688, 0950-2688
KW  - Microbiology Abstracts B: Bacteriology
KW  - Infectious diseases
KW  - Models
KW  - Hospitals
KW  - J 02400:Human Diseases
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667004777?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Prediction+of+rodent+carcinogenic+potential+of+naturally+occurring+chemicals+in+the+human+diet+using+high-throughput+QSAR+predictive+modeling&rft.au=Valerio%2C+L+G%3BArvidson%2C+K+B%3BChanderbhan%2C+R+F%3BContrera%2C+J+F&rft.aulast=Valerio&rft.aufirst=L&rft.date=2007-07-01&rft.volume=222&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.03.012
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Infectious diseases; Hospitals; Models
DO  - http://dx.doi.org/10.1017/S0950268807008977
ER  - 



TY  - JOUR
T1  - Diagnosing and controlling moisture-sensitive roof in coal mines
AN  - 1560085620; 2014-066486
AB  - Historically, coal miners have known that roof shales can deteriorate in contact with humid mine air, causing massive roof falls and injuries from falling rock. It is critical to recognize rocks prone to weathering and to adequately support these rocks in order to ensure the long-term stability of the openings. In a recent study, NIOSH has used a wet/dry cycling test to determine the moisture sensitivity of over 800 specimens of roof rock from 25 U.S. coal mines. Fireclays and some gray shales are the most moisture-sensitive. Rocks with disturbed bedding, in contrast to flat-bedded rocks, are also more sensitive to water. Black shales are relatively un-reactive to moisture and serve to protect more reactive gray shales above. Mines that have roof rocks with moisture-sensitivity indexes above 40% can experience slaking roof conditions, and many require high coverage surface controls. Three case studies are presented in which the moisture-sensitivity index is correlated to roof conditions underground, and can be used to indicate long term deterioration. Engineering measures are described to control moisture-sensitive roof. In one case, roof screen not only reduces injuries from rock fall but also is shown to reduce roof falls.
JF  - The Electronic Journal of Geotechnical Engineering
AU  - Molinda, Greg
AU  - Klemetti, Ted
Y1  - 2008
PY  - 2008
DA  - 2008
SP  - 20
PB  - Mete Oner, Stillwater, OK
VL  - 13
IS  - Bundle A
KW  - United States
KW  - mines
KW  - shale
KW  - roof control
KW  - moisture
KW  - coal mines
KW  - stability
KW  - weathering
KW  - rock mechanics
KW  - case studies
KW  - black shale
KW  - sedimentary rocks
KW  - mining geology
KW  - clastic rocks
KW  - fireclay
KW  - 30:Engineering geology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Electronic+Journal+of+Geotechnical+Engineering&rft.atitle=Diagnosing+and+controlling+moisture-sensitive+roof+in+coal+mines&rft.au=Molinda%2C+Greg%3BKlemetti%2C+Ted&rft.aulast=Molinda&rft.aufirst=Greg&rft.date=2008-01-01&rft.volume=13&rft.issue=Bundle+A&rft.spage=&rft.isbn=&rft.btitle=&rft.title=The+Electronic+Journal+of+Geotechnical+Engineering&rft.issn=1089-3032&rft_id=info:doi/
L2  - http://www.ejge.com/Index_ejge.htm
LA  - English
DB  - GeoRef
N1  - Copyright - GeoRef, Copyright 2017, American Geosciences Institute.
N1  - Date revised - 2014-01-01
N1  - Number of references - 21
N1  - PubXState - OK
N1  - Document feature - illus. incl. 2 tables, sketch maps
N1  - Last updated - 2017-01-19
N1  - SubjectsTermNotLitGenreText - black shale; case studies; clastic rocks; coal mines; fireclay; mines; mining geology; moisture; rock mechanics; roof control; sedimentary rocks; shale; stability; United States; weathering
ER  - 



TY  - JOUR
T1  - Over-the-counter vaginal contraceptive and spermicide drug products containing nonoxynol 9; required labeling. Final rule.
AN  - 69082878; 18159651
AB  - The Food and Drug Administration (FDA) is issuing a final rule establishing new warning statements and other labeling information for all over-the-counter (OTC) vaginal contraceptive drug products (also known as spermicides, hereinafter referred to as vaginal contraceptives or vaginal contraceptives/spermicides) containing nonoxynol 9 (N9). These warning statements will advise consumers that vaginal contraceptives/spermicides containing N9 do not protect against infection from the human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), or against getting other sexually transmitted diseases (STDs). The warnings and labeling information will also advise consumers that use of vaginal contraceptives and spermicides containing N9 can irritate the vagina and rectum and may increase the risk of getting the AIDS virus (HIV) from an infected partner. This final rule is part of FDA's ongoing review of OTC drug products. FDA is issuing this final rule after considering public comments on its proposed regulation, and all relevant data and information on N9 that have come to our attention.
JF  - Federal register
AU  - Food and Drug Administration, HHS
AD  - Food and Drug Administration, HHS
Y1  - 2007/12/19/
PY  - 2007
DA  - 2007 Dec 19
SP  - 71769
EP  - 71785
VL  - 72
IS  - 243
SN  - 0097-6326, 0097-6326
KW  - Contraceptive Agents
KW  - 0
KW  - Nonprescription Drugs
KW  - Spermatocidal Agents
KW  - Nonoxynol
KW  - 26027-38-3
KW  - Health technology assessment
KW  - United States
KW  - Condoms
KW  - Nonprescription Drugs -- adverse effects
KW  - HIV Infections -- transmission
KW  - Nonprescription Drugs -- therapeutic use
KW  - Humans
KW  - HIV Infections -- prevention & control
KW  - Nonprescription Drugs -- administration & dosage
KW  - Sexually Transmitted Diseases -- prevention & control
KW  - Sexually Transmitted Diseases -- transmission
KW  - Male
KW  - Female
KW  - Contraceptive Agents -- therapeutic use
KW  - Spermatocidal Agents -- adverse effects
KW  - Nonoxynol -- administration & dosage
KW  - Contraceptive Agents -- administration & dosage
KW  - Nonoxynol -- therapeutic use
KW  - Spermatocidal Agents -- administration & dosage
KW  - Nonoxynol -- adverse effects
KW  - Drug Labeling -- legislation & jurisprudence
KW  - Spermatocidal Agents -- therapeutic use
KW  - Contraceptive Agents -- adverse effects
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69082878?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Over-the-counter+vaginal+contraceptive+and+spermicide+drug+products+containing+nonoxynol+9%3B+required+labeling.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2007-12-19&rft.volume=72&rft.issue=243&rft.spage=71769&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-11
N1  - Date created - 2007-12-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Epigenetic changes in the rat livers induced by pyrazinamide treatment
AN  - 20841297; 7939496
AB  - Drug-induced liver injury, including drug-induced hepatotoxicity during the treatment of tuberculosis infection, is a major health problem with increasingly significant challenges to modern hepatology. Therefore, the assessment and monitoring of the hepatotoxicity of antituberculosis drugs for prevention of liver injury are great concerns during disease treatment. The recently emerged data showing the ability of toxicants, including pharmaceutical agents, to alter cellular epigenetic status, open a unique opportunity for early detection of drug hepatotoxicity. Here we report that treatment of male Wistar rats with antituberculosis drug pyrazinamide at doses of 250, 500 or 1000 mg/kg/day body weight for 45 days leads to an early and sustained decrease in cytosine DNA methylation, progressive hypomethylation of long interspersed nucleotide elements (LINE-1), and aberrant promoter hypermethylation of placental form glutathione-S-transferase (GSTP) and p16 super(I) super(N) super(K) super(4) super(A) genes in livers of pyrazinamide-treated rats, while serum levels of bilirubin and activity of aminotransferases changed modestly. The early occurrence of these epigenetic alterations and their association with progression of liver injury specific pathological changes indicate that alterations in DNA methylation may be useful predictive markers for the assessment of drug hepatotoxicity.
JF  - Toxicology and Applied Pharmacology
AU  - Kovalenko, V M
AU  - Bagnyukova, T V
AU  - Sergienko, O V
AU  - Bondarenko, L B
AU  - Shayakhmetova, G M
AU  - Matvienko, A V
AU  - Pogribny, I P
AD  - Jefferson, AR, USA, igor.pogribny@fda.hhs.gov
Y1  - 2007/12/15/
PY  - 2007
DA  - 2007 Dec 15
SP  - 293
EP  - 299
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 225
IS  - 3
SN  - 0041-008X, 0041-008X
KW  - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Toxicology Abstracts
KW  - Toxicants
KW  - Injuries
KW  - Mycobacterium
KW  - Glutathione transferase
KW  - Infection
KW  - Drug screening
KW  - Promoters
KW  - Cytosine
KW  - p16 protein
KW  - Body weight
KW  - epigenetics
KW  - Placenta
KW  - DNA methylation
KW  - Long interspersed nucleotide elements
KW  - Tuberculosis
KW  - Bilirubin
KW  - Drugs
KW  - Data processing
KW  - INK4a protein
KW  - hepatotoxicity
KW  - Serum levels
KW  - Liver
KW  - Pharmaceuticals
KW  - pyrazinamide
KW  - J 02310:Genetics & Taxonomy
KW  - X 24310:Pharmaceuticals
KW  - N 14820:DNA Metabolism & Structure
KW  - G 07870:Mammals
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Epigenetic+changes+in+the+rat+livers+induced+by+pyrazinamide+treatment&rft.au=Kovalenko%2C+V+M%3BBagnyukova%2C+T+V%3BSergienko%2C+O+V%3BBondarenko%2C+L+B%3BShayakhmetova%2C+G+M%3BMatvienko%2C+A+V%3BPogribny%2C+I+P&rft.aulast=Kovalenko&rft.aufirst=V&rft.date=2007-12-15&rft.volume=225&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.08.011
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Data processing; Injuries; Toxicants; INK4a protein; Drug screening; Infection; Glutathione transferase; hepatotoxicity; Serum levels; Cytosine; Promoters; p16 protein; Body weight; epigenetics; Placenta; Liver; DNA methylation; Pharmaceuticals; Long interspersed nucleotide elements; Bilirubin; Tuberculosis; pyrazinamide; Drugs; Mycobacterium
DO  - http://dx.doi.org/10.1016/j.taap.2007.08.011
ER  - 



TY  - JOUR
T1  - Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.
AN  - 69056043; 18074021
AB  - DNA helicases are ubiquitous enzymes that unwind DNA in an ATP-dependent and directionally specific manner. Unwinding of double-stranded DNA is essential for the processes of DNA repair, recombination, transcription, and DNA replication. Five human DNA helicases sharing sequence similarity with the E. coli RecQ helicase have been identified. Three of the human RecQ helicases are implicated in hereditary diseases (Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome) which display clinical symptoms of premature aging and cancer. RECQ1 helicase is the most highly expressed of the human RecQ helicases; however, a genetic disease has yet not been linked to mutations in the RECQ1 gene, and the biological functions of human RECQ1 in cellular DNA metabolism are not known.
          In this study, we report that RECQ1 becomes phosphorylated upon DNA damage and forms irradiation-induced nuclear foci that associate with chromatin in human cells. Depletion of RECQ1 renders human cells sensitive to DNA damage induced by ionizing radiation or the topoisomerase inhibitor camptothecin, and results in spontaneous gamma-H2AX foci and elevated sister chromatid exchanges, indicating aberrant repair of DNA breaks. Consistent with a role in homologous recombinational repair, endogenous RECQ1 is associated with the strand exchange protein Rad51 and the two proteins directly interact with high affinity. Collectively, these results provide the first evidence for a role of human RECQ1 in the response to DNA damage and chromosomal stability maintenance and point to the vital importance of RECQ1 in genome homeostasis.
JF  - PloS one
AU  - Sharma, Sudha
AU  - Brosh, Robert M
AD  - Laboratory of Molecular Gerontology, Department of Health and Human Services, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.
Y1  - 2007/12/12/
PY  - 2007
DA  - 2007 Dec 12
SP  - 1
VL  - 2
IS  - 12
KW  - Mutagens
KW  - 0
KW  - RNA, Small Interfering
KW  - RecQ Helicases
KW  - EC 3.6.4.12
KW  - Index Medicus
KW  - Base Sequence
KW  - HeLa Cells
KW  - Humans
KW  - Sister Chromatid Exchange
KW  - DNA Damage
KW  - RecQ Helicases -- metabolism
KW  - Oxidative Stress
KW  - RecQ Helicases -- genetics
KW  - Mutagens -- toxicity
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69056043?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Human+RECQ1+is+a+DNA+damage+responsive+protein+required+for+genotoxic+stress+resistance+and+suppression+of+sister+chromatid+exchanges.&rft.au=Sharma%2C+Sudha%3BBrosh%2C+Robert+M&rft.aulast=Sharma&rft.aufirst=Sudha&rft.date=2007-12-12&rft.volume=2&rft.issue=12&rft.spage=e1297&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-08-08
N1  - Date created - 2007-12-12
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543]
Nature. 2003 Dec 18;426(6968):870-4 [14685245]
Mol Cell Biol. 2004 Feb;24(3):1279-91 [14729972]
Curr Genet. 2004 Feb;45(1):37-44 [14595518]
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J Cell Sci. 2005 Sep 15;118(Pt 18):4261-9 [16141230]
Mol Cell Biol. 2005 Oct;25(20):8925-37 [16199871]
Nucleic Acids Res. 2005;33(19):6251-7 [16260474]
Genetics. 2006 Jan;172(1):113-25 [16219790]
Cancer Res. 2006 Mar 15;66(6):3323-30 [16540687]
J Clin Oncol. 2006 Apr 10;24(11):1720-8 [16520463]
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5875-80 [16595622]
Science. 2006 Jul 21;313(5785):363-7 [16778019]
Biochem J. 2006 Sep 15;398(3):319-37 [16925525]
Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856]
Mol Cell Biol. 2007 Mar;27(5):1784-94 [17158923]
PLoS Biol. 2007 Feb;5(2):e20 [17227144]
J Cell Sci. 2007 Mar 1;120(Pt 5):713-21 [17314245]
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Nat Struct Mol Biol. 2007 Jul;14(7):677-9 [17603497]
Oncogene. 2000 Sep 28;19(41):4764-72 [11032027]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles.
AN  - 68539997; 17981407
AB  - In order to evaluate the pulmonary effects and inflammatory mechanisms of ultrafine amorphous silica particles (UFASs), the UFASs suspension was prepared in PBS and intratracheally administered to A/J mice at doses of 0, 2, 10 and 50mg/kg (n=5 per group). Animals were sacrificed at 24h, and 1, 4 or 14 weeks following exposures. At each time point, a bronchoalveolar lavage fluid analysis, histopathological examination, quantitative real-time PCR and immunohistochemistry of the lung tissues were assessed. The intratracheal instillation of UFASs significantly increased the lung weights and total BAL cells following exposures. The histopathological examination revealed that UFASs-induced severe inflammation, with neutrophils, at an early stage and chronic granulomatous inflammation at the later stage. The mRNA and protein levels of IL-1beta, IL-6, IL-8, TNF-alpha, MCP-1 and MIP-2 in lung tissues were significantly increased during the early stages, but there were no changes after weeks 1 (TNF-alpha) or 4 (IL-1beta, IL-6, IL-8, MCP-1 and MIP-2). Instillation of UFASs-induced transient, but very severe lung inflammation. Therefore, the cytokines (IL-1beta, IL-6, IL-8 and TNF-alpha) and chemokines (MCP-1 and MIP-2) play important roles in the inflammation induced by the intratracheal instillation of UFASs.
JF  - Toxicology letters
AU  - Cho, Wan-Seob
AU  - Choi, Mina
AU  - Han, Beom Seok
AU  - Cho, Minjung
AU  - Oh, Jaeho
AU  - Park, Kidae
AU  - Kim, Sung Jun
AU  - Kim, Seung Hee
AU  - Jeong, Jayoung
AD  - Division of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea.
Y1  - 2007/12/10/
PY  - 2007
DA  - 2007 Dec 10
SP  - 24
EP  - 33
VL  - 175
IS  - 1-3
SN  - 0378-4274, 0378-4274
KW  - Cytokines
KW  - 0
KW  - Inflammation Mediators
KW  - Proteins
KW  - RNA, Messenger
KW  - Silicon Dioxide
KW  - 7631-86-9
KW  - Index Medicus
KW  - Animals
KW  - Macrophages -- immunology
KW  - Particle Size
KW  - Mice
KW  - RNA, Messenger -- biosynthesis
KW  - Leukocyte Count
KW  - Inflammation Mediators -- metabolism
KW  - Bronchoalveolar Lavage Fluid -- chemistry
KW  - Proteins -- analysis
KW  - Up-Regulation
KW  - Administration, Inhalation
KW  - Bronchoalveolar Lavage Fluid -- cytology
KW  - Male
KW  - Organ Size -- drug effects
KW  - Cytokines -- genetics
KW  - Cytokines -- biosynthesis
KW  - Lung -- drug effects
KW  - Silicon Dioxide -- toxicity
KW  - Lung -- pathology
KW  - Lung -- metabolism
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68539997?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Inflammatory+mediators+induced+by+intratracheal+instillation+of+ultrafine+amorphous+silica+particles.&rft.au=Cho%2C+Wan-Seob%3BChoi%2C+Mina%3BHan%2C+Beom+Seok%3BCho%2C+Minjung%3BOh%2C+Jaeho%3BPark%2C+Kidae%3BKim%2C+Sung+Jun%3BKim%2C+Seung+Hee%3BJeong%2C+Jayoung&rft.aulast=Cho&rft.aufirst=Wan-Seob&rft.date=2007-12-10&rft.volume=175&rft.issue=1-3&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-21
N1  - Date created - 2007-11-23
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - S-ethyl-N,N-dipropylthiocarbamate (EPTC) Exposure and Cancer Incidence among Male Pesticide Applicators in the Agricultural Health Study, a Prospective Cohort.
T2  - Sixth Annual Frontiers in Cancer Prevention Research Conference
AN  - 40809096; 4802173
JF  - Sixth Annual Frontiers in Cancer Prevention Research Conference
AU  - Van Bemmel, D M
AU  - Visvanathan, K
AU  - Freeman, L. E. Beane
AU  - Coble, J B
AU  - Hoppin, J A
AU  - Alavanja, M. C.R.
Y1  - 2007/12/05/
PY  - 2007
DA  - 2007 Dec 05
KW  - Cancer
KW  - Pesticides
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40809096?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=S-ethyl-N%2CN-dipropylthiocarbamate+%28EPTC%29+Exposure+and+Cancer+Incidence+among+Male+Pesticide+Applicators+in+the+Agricultural+Health+Study%2C+a+Prospective+Cohort.&rft.au=Van+Bemmel%2C+D+M%3BVisvanathan%2C+K%3BFreeman%2C+L.+E.+Beane%3BCoble%2C+J+B%3BHoppin%2C+J+A%3BAlavanja%2C+M.+C.R.&rft.aulast=Van+Bemmel&rft.aufirst=D&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/
L2  - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Evidence for the reaffirmation of the U.S. Preventive Services Task Force recommendation on screening for high blood pressure.
AN  - 69031116; 18056663
AB  - High blood pressure is common, and screening is a well-established evidence-based standard of current medical practice.
          To perform a literature search for new, substantial evidence on screening for high blood pressure that would inform the reaffirmation of the U.S. Preventive Services Task Force recommendation on screening for high blood pressure. The PubMed and Cochrane databases were searched. The searches were limited to English-language articles on studies of adult humans (age >18 years) that were published between 1 October 2001 and 31 March 2006 in core clinical journals.
          For the literature on benefits, meta-analyses; systematic reviews; and randomized, controlled trials were included. For harms, meta-analyses; systematic reviews; randomized, controlled trials; cohort studies; case-control studies; and case series of large, multisite databases were included. Two reviewers independently reviewed titles, abstracts, and full articles for inclusion.
          No new evidence was found on benefits or harms of screening. Two reviewers extracted data from studies on the harms of early treatment, including adverse effects of drug therapy and adverse quality-of-life outcomes. No new evidence was found for the benefits of screening for high blood pressure. New evidence on the harms of treatment of early hypertension shows that pharmacologic therapy is associated with common side effects; serious adverse events are uncommon.
          The nonsystematic search may have missed some smaller studies on the benefits and harms of screening and treatment for high blood pressure. No new evidence was found on the benefits of screening. Pharmacotherapy for early hypertension is associated with common side effects.
JF  - Annals of internal medicine
AU  - Wolff, Tracy
AU  - Miller, Therese
AD  - .S. Preventive Services Task Force Program, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA.
Y1  - 2007/12/04/
PY  - 2007
DA  - 2007 Dec 04
SP  - 787
EP  - 791
VL  - 147
IS  - 11
KW  - Antihypertensive Agents
KW  - 0
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Cardiovascular Diseases -- etiology
KW  - Risk Factors
KW  - Humans
KW  - Antihypertensive Agents -- adverse effects
KW  - Adult
KW  - Time Factors
KW  - Male
KW  - Female
KW  - Cardiovascular Diseases -- prevention & control
KW  - Hypertension -- complications
KW  - Hypertension -- diagnosis
KW  - Mass Screening -- adverse effects
KW  - Hypertension -- prevention & control
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Evidence+for+the+reaffirmation+of+the+U.S.+Preventive+Services+Task+Force+recommendation+on+screening+for+high+blood+pressure.&rft.au=Wolff%2C+Tracy%3BMiller%2C+Therese&rft.aulast=Wolff&rft.aufirst=Tracy&rft.date=2007-12-04&rft.volume=147&rft.issue=11&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-10
N1  - Date created - 2007-12-06
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Summary For Patients In:
Ann Intern Med. 2007 Dec 4;147(11):I43 [18056657]
N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - The Impact of Underage Drinking and the Risk of HIV Among African Americans
T2  - 2007 National HIV Prevention Conference
AN  - 39716091; 4737329
JF  - 2007 National HIV Prevention Conference
AU  - Richards, C
AU  - Cooke, V C
AU  - Schaffer, T M
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - Africa
KW  - Human immunodeficiency virus
KW  - Ethnic groups
KW  - Drinking
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39716091?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=The+Impact+of+Underage+Drinking+and+the+Risk+of+HIV+Among+African+Americans&rft.au=Richards%2C+C%3BCooke%2C+V+C%3BSchaffer%2C+T+M&rft.aulast=Richards&rft.aufirst=C&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/
L2  - http://www.2007nhpc.org/conference_program.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Adapting the Popular Opinion Leader Intervention for Young Black Men Who have Sex with Men: Focusing on Peer Norms, Culture, and Social Stigma
T2  - 2007 National HIV Prevention Conference
AN  - 39662983; 4737164
JF  - 2007 National HIV Prevention Conference
AU  - Bost, D L
AU  - Jones, K T
AU  - Foust, E M
AU  - Gray, P A
AU  - Whiteside, Y O
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - Opinion leaders
KW  - Homosexuality
KW  - Intervention
KW  - Stigma
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39662983?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Adapting+the+Popular+Opinion+Leader+Intervention+for+Young+Black+Men+Who+have+Sex+with+Men%3A+Focusing+on+Peer+Norms%2C+Culture%2C+and+Social+Stigma&rft.au=Bost%2C+D+L%3BJones%2C+K+T%3BFoust%2C+E+M%3BGray%2C+P+A%3BWhiteside%2C+Y+O&rft.aulast=Bost&rft.aufirst=D&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/
L2  - http://www.2007nhpc.org/conference_program.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Training and Implementation for Protocol-Based Counseling (PBC) in Houston: An Evidence-Based CTR Intervention
T2  - 2007 National HIV Prevention Conference
AN  - 39653523; 4737185
JF  - 2007 National HIV Prevention Conference
AU  - Agee, G B
AU  - Wiley, C
AU  - Hall, H
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - USA, Texas, Houston
KW  - Training
KW  - Intervention
KW  - U 2000:Biological Sciences
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Creating HIV/STD Prevention Standards to Improve Quality Management Activities: A Houston Perspective
T2  - 2007 National HIV Prevention Conference
AN  - 39634796; 4737113
JF  - 2007 National HIV Prevention Conference
AU  - Mitts, B J
AU  - Joseph-White, D
AU  - Kweekeh, F
AU  - Washington-Philip, E
AU  - Simpson, B
AU  - Prescott, L
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - USA, Texas, Houston
KW  - Human immunodeficiency virus
KW  - Prevention
KW  - Sexually-transmitted diseases
KW  - U 2000:Biological Sciences
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N1  - Date revised - 2007-12-18
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TY  - CPAPER
T1  - Prenatal HIV Screening: Ongoing Challenges and Lessons Learned
T2  - 2007 National HIV Prevention Conference
AN  - 39634431; 4737045
JF  - 2007 National HIV Prevention Conference
AU  - Reilley, B
AU  - Giberson, S
AU  - Cheek, J
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - Human immunodeficiency virus
KW  - Screening
KW  - U 2000:Biological Sciences
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LA  - English
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N1  - Date revised - 2007-12-18
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TY  - CPAPER
T1  - HIV/STD Planning and Implementation Through Community Groups
T2  - 2007 National HIV Prevention Conference
AN  - 39628256; 4737121
JF  - 2007 National HIV Prevention Conference
AU  - Hall, H H
AU  - Agee, G
AU  - Wiley, C
AU  - Cavazos, J
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - Human immunodeficiency virus
KW  - Sexually-transmitted diseases
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - The Use of Surveillance Data to Evaluate Concurrent HIV and AIDS Diagnoses in Houston/Harris County, TX
T2  - 2007 National HIV Prevention Conference
AN  - 39622029; 4737493
JF  - 2007 National HIV Prevention Conference
AU  - Chan, S
AU  - Yang, B
AU  - Mohammad, N
AU  - Harms, J
AU  - Wolverton, M
AU  - Meyer, J
AU  - Arafat, R
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - USA, Texas, Houston
KW  - Human immunodeficiency virus
KW  - Acquired immune deficiency syndrome
KW  - U 2000:Biological Sciences
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N1  - Date revised - 2007-12-18
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TY  - CPAPER
T1  - Breaking the Cycle/Mending the Hoop: Adverse Childhood Experiences Among Incarcerated American Indian and Alaska Native Women in New Mexico
T2  - 2007 National HIV Prevention Conference
AN  - 39609860; 4737394
JF  - 2007 National HIV Prevention Conference
AU  - De Ravello, L
AU  - Abeita, J
AU  - Brown, P
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - USA, New Mexico
KW  - USA, Alaska
KW  - Children
KW  - U 2000:Biological Sciences
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N1  - Date revised - 2007-12-18
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ER  - 



TY  - CPAPER
T1  - Development of a Local Capacity Building and Training Unit: Houstons Perspective
T2  - 2007 National HIV Prevention Conference
AN  - 39606091; 4737623
JF  - 2007 National HIV Prevention Conference
AU  - Wiley, C P
AU  - Agee, G
AU  - Hall, H H
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - USA, Texas, Houston
KW  - Training
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Signs of the Time "Houston's Approach to Quality Management Through Realignment of Job Functions"
T2  - 2007 National HIV Prevention Conference
AN  - 39596145; 4737449 DE:
JF  - 2007 National HIV Prevention Conference
AU  - Simpson, B
AU  - Washington-Philip, E
AU  - Kweekeh, F
AU  - Joseph-White, D
AU  - Prescott, L
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - U 2000:Biological Sciences
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N1  - Date revised - 2007-12-18
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TY  - CPAPER
T1  - The Indian Health Service's HIV Management System Clinical Software
T2  - 2007 National HIV Prevention Conference
AN  - 39571826; 4737416
JF  - 2007 National HIV Prevention Conference
AU  - Cullen, T
AU  - Gebremariam, C P
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - Human immunodeficiency virus
KW  - Computer programs
KW  - Software
KW  - U 2000:Biological Sciences
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LA  - English
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N1  - Date revised - 2007-12-18
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ER  - 



TY  - CPAPER
T1  - Surveillance Dos and Donts: False Positive HIV Western Blots in Pregnant Women
T2  - 2007 National HIV Prevention Conference
AN  - 39525546; 4737618
JF  - 2007 National HIV Prevention Conference
AU  - Chan, S
AU  - Harms, J
AU  - Yang, B
AU  - Mohammad, N
AU  - Meyer, J
AU  - Wolverton, M
AU  - Arafat, R
Y1  - 2007/12/02/
PY  - 2007
DA  - 2007 Dec 02
KW  - Human immunodeficiency virus
KW  - Western blotting
KW  - Pregnancy
KW  - U 2000:Biological Sciences
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Backpropagation ANN-Based Prediction of Exertional Heat Illness
AN  - 757015561; 18041290
AB  - Exertional heat illness is primarily a multi-system disorder results from the combined effect of exertional and thermoregulation stress. The severity of exertional heat illness can be classified as mild, intermediate and severe from non-specific symptoms like thirst, myalgia, poor concentration, hysteria, vomiting, weakness, cramps, impaired judgement, headache, diarrhea, fatigue, hyperventilation, anxiety, and nausea to more severe symptoms like exertional dehydration, heat cramps, heat exhaustion, heat injury, heatstroke, rhabdomyolysis, and acute renal failure. At its early stage, it is quite difficult to find out the severity of disease with manual screening because of overlapping of symptoms. Therefore, one need to classify automatically the disease based on symptoms. The 7:10:1 backpropagation artificial neural network model has been used to predict the clinical outcome from the symptoms that are routinely available to clinicians. The model has found to be effective in differentiating the different stages of exertional heat-illness with an overall performance of 100%.[PUBLICATION ABSTRACT]
JF  - Journal of Medical Systems
AU  - Aggarwal, Yogender
AU  - Karan, Bhuwan Mohan
AU  - Das, Barda Nand
AU  - Aggarwal, Tarana
AU  - Sinha, Rakesh Kumar
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 547
EP  - 50
CY  - New York
PB  - Springer Science & Business Media
VL  - 31
IS  - 6
SN  - 0148-5598
KW  - Medical Sciences--Computer Applications
KW  - Neural networks
KW  - Heatstroke
KW  - Back propagation
KW  - Illnesses
KW  - Body Temperature Regulation
KW  - Humans
KW  - Heat Exhaustion -- diagnosis
KW  - Outcome Assessment (Health Care)
KW  - India
KW  - Heat Exhaustion -- physiopathology
KW  - Neural Networks (Computer)
KW  - Physical Exertion -- physiology
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LA  - English
DB  - ProQuest Central
N1  - Copyright - Springer Science+Business Media, LLC 2007
N1  - Last updated - 2014-07-26
DO  - http://dx.doi.org/10.1007/s10916-007-9097-5
ER  - 



TY  - JOUR
T1  - Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas.
AN  - 70089026; 18247017
AB  - Erlotinib (Tarceva) is a human epidermal growth factor receptor type 1/epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor initially approved by the US Food and Drug Administration for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer after failure of at least one prior chemotherapy regimen. In this report, we present the pivotal study that led to the approval of erlotinib in combination with gemcitabine (Gemzar) in patients with locally advanced/metastatic chemonaive pancreatic cancer patients. The combination demonstrated a statistically significant increase in overall survival accompanied by an increase in toxicity. Physicians and patients now have a new option for the treatment of locally advanced/metastatic adenocarcinoma of the pancreas.
JF  - Oncology (Williston Park, N.Y.)
AU  - Senderowicz, Adrian M
AU  - Johnson, John R
AU  - Sridhara, Rajeshwari
AU  - Zimmerman, Paul
AU  - Justice, Robert
AU  - Pazdur, Richard
AD  - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. adrian.senderowicz@fda.gov
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 1696
EP  - 706; discussion 1706-9, 1712, 1715
VL  - 21
IS  - 14
SN  - 0890-9091, 0890-9091
KW  - Antimetabolites, Antineoplastic
KW  - 0
KW  - Protein Kinase Inhibitors
KW  - Quinazolines
KW  - Deoxycytidine
KW  - 0W860991D6
KW  - gemcitabine
KW  - B76N6SBZ8R
KW  - Erlotinib Hydrochloride
KW  - DA87705X9K
KW  - Receptor, Epidermal Growth Factor
KW  - EC 2.7.10.1
KW  - Index Medicus
KW  - Receptor, Epidermal Growth Factor -- antagonists & inhibitors
KW  - Antimetabolites, Antineoplastic -- administration & dosage
KW  - Double-Blind Method
KW  - Antimetabolites, Antineoplastic -- adverse effects
KW  - Humans
KW  - Deoxycytidine -- analogs & derivatives
KW  - Protein Kinase Inhibitors -- administration & dosage
KW  - Aged
KW  - Quinazolines -- administration & dosage
KW  - Deoxycytidine -- adverse effects
KW  - Protein Kinase Inhibitors -- adverse effects
KW  - Aged, 80 and over
KW  - Adult
KW  - Cohort Studies
KW  - Deoxycytidine -- administration & dosage
KW  - Middle Aged
KW  - Quinazolines -- adverse effects
KW  - Male
KW  - Female
KW  - Survival Analysis
KW  - Pancreatic Neoplasms -- pathology
KW  - Adenocarcinoma -- secondary
KW  - Pancreatic Neoplasms -- drug therapy
KW  - Antineoplastic Combined Chemotherapy Protocols -- adverse effects
KW  - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
KW  - Adenocarcinoma -- drug therapy
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-05-06
N1  - Date created - 2008-02-05
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Characteristics of dusts encountered during the production of cemented tungsten carbides.
AN  - 70076805; 18212475
AB  - Inhalation of cobalt (Co) and tungsten carbide (WC) particles, but not Co or WC alone, may cause hard metal disease, risk of which does not appear to be uniform across cemented tungsten carbide (CTC) production processes. Inhalation of Co alone or in the presence of WC may cause asthma. Hypothesizing that aerosol size, chemical content, heterogeneity, and constituent compaction may be important exposure factors, we characterized aerosols from representative CTC manufacturing processes. Six work areas were sampled to characterize aerosol size distributions (dust, Co) and 12 work areas were sampled to characterize physicochemical properties (using scanning electron microscopy with energy dispersive x-ray spectrometry [SEM-EDX]). Bulk feedstock and process-generated powders were characterized with SEM-EDX and x-ray diffraction. The dust mass median diameter was respirable and the cobalt respirable mass fraction was highest (37%) in grinding. Morphology of particles changed with processing: individual, agglomerate, or aggregates (pre-sintered materials), then mostly compacted particles (subsequent to sintering). Elemental composition of particles became increasingly heterogeneous: mostly discrete Co or W particles (prior to spray drying), then heterogeneous W/Co particles (subsequent work areas). Variability in aerosol respirability and chemical heterogeneity could translate into differences in toxicity and support detailed characterization of physicochemical properties during exposure assessments.
JF  - Industrial health
AU  - Stefaniak, Aleksandr B
AU  - Day, Gregory A
AU  - Harvey, Christopher J
AU  - Leonard, Stephen S
AU  - Schwegler-Berry, Diane E
AU  - Chipera, Steve J
AU  - Sahakian, Nancy M
AU  - Chisholm, William P
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 793
EP  - 803
VL  - 45
IS  - 6
SN  - 0019-8366, 0019-8366
KW  - Aerosols
KW  - 0
KW  - Air Pollutants, Occupational
KW  - Alloys
KW  - Dust
KW  - hard metal
KW  - Cobalt
KW  - 3G0H8C9362
KW  - Tungsten
KW  - V9306CXO6G
KW  - Index Medicus
KW  - Aerosols -- analysis
KW  - Particle Size
KW  - Asthma -- chemically induced
KW  - Occupational Diseases -- chemically induced
KW  - Environmental Monitoring -- methods
KW  - Alloys -- analysis
KW  - Dust -- analysis
KW  - Air Pollutants, Occupational -- analysis
KW  - Tungsten -- analysis
KW  - Air Pollutants, Occupational -- adverse effects
KW  - Occupational Exposure -- adverse effects
KW  - Cobalt -- analysis
KW  - Cobalt -- adverse effects
KW  - Alloys -- adverse effects
KW  - Tungsten -- adverse effects
KW  - Manufactured Materials
KW  - Occupational Exposure -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-22
N1  - Date created - 2008-01-23
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - A prospective study of red and processed meat intake in relation to cancer risk.
AN  - 69086300; 18076279
AB  - Red meat and processed meat have been associated with carcinogenesis at several anatomic sites, but no prospective study has examined meat intake in relation to a range of malignancies. We investigated whether red or processed meat intake increases cancer risk at a variety of sites.
          The National Institutes of Health (NIH)-AARP (formerly the American Association for Retired Persons) Diet and Health Study is a cohort of approximately 500,000 people aged 50-71 y at baseline (1995-1996). Meat intake was estimated from a food frequency questionnaire administered at baseline. Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals within quintiles of red and processed meat intake. During up to 8.2 y of follow-up, 53,396 incident cancers were ascertained. Statistically significant elevated risks (ranging from 20% to 60%) were evident for esophageal, colorectal, liver, and lung cancer, comparing individuals in the highest with those in the lowest quintile of red meat intake. Furthermore, individuals in the highest quintile of processed meat intake had a 20% elevated risk for colorectal and a 16% elevated risk for lung cancer. Both red and processed meat intakes were positively associated with cancers of the colorectum and lung; furthermore, red meat intake was associated with an elevated risk for cancers of the esophagus and liver.
JF  - PLoS medicine
AU  - Cross, Amanda J
AU  - Leitzmann, Michael F
AU  - Gail, Mitchell H
AU  - Hollenbeck, Albert R
AU  - Schatzkin, Arthur
AU  - Sinha, Rashmi
AD  - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America. crossa@mail.nih.gov
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 1
VL  - 4
IS  - 12
KW  - Index Medicus
KW  - Sex Factors
KW  - Nutrition Assessment
KW  - Humans
KW  - Aged
KW  - Risk Assessment
KW  - Lung Neoplasms -- etiology
KW  - Prospective Studies
KW  - Risk Factors
KW  - Surveys and Questionnaires
KW  - Colorectal Neoplasms -- etiology
KW  - Incidence
KW  - Follow-Up Studies
KW  - Middle Aged
KW  - Esophageal Neoplasms -- etiology
KW  - Liver Neoplasms -- etiology
KW  - United States -- epidemiology
KW  - Time Factors
KW  - Female
KW  - Male
KW  - Proportional Hazards Models
KW  - Meat Products -- adverse effects
KW  - Meat -- adverse effects
KW  - Neoplasms -- epidemiology
KW  - Neoplasms -- etiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-10
N1  - Date created - 2007-12-28
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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Carcinogenesis. 1998 Jan;19(1):117-24 [9472702]
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Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044]
Leuk Res. 1998 May;22(5):445-52 [9652731]
J Med Microbiol. 1998 May;47(5):407-16 [9879941]
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Cancer Causes Control. 1998 Dec;9(6):621-30 [10189048]
Am J Epidemiol. 1999 May 15;149(10):925-32 [10342801]
Br J Cancer. 1999 Jun;80(7):1107-13 [10362125]
Gut. 1999 Jul;45(1):45-50 [10369703]
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Comment In:
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Comment On:
PLoS Med. 2007 Dec;4(12):e354 [18076283]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Nuclear factor-kappaB, an unappreciated tumor suppressor.
AN  - 69033844; 18056430
AB  - The notion that nuclear factor-kappaB (NF-kappaB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappaB in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-kappaB remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-kappaB activation as a broad strategy in treating cancers.
JF  - Cancer research
AU  - Chen, Fei
AU  - Castranova, Vince
AD  - The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. fchen@cdc.gov
Y1  - 2007/12/01/
PY  - 2007
DA  - 2007 Dec 01
SP  - 11093
EP  - 11098
VL  - 67
IS  - 23
KW  - NF-kappa B
KW  - 0
KW  - Index Medicus
KW  - Humans
KW  - Neoplasms -- drug therapy
KW  - Genes, Tumor Suppressor -- physiology
KW  - NF-kappa B -- physiology
KW  - NF-kappa B -- antagonists & inhibitors
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-22
N1  - Date created - 2007-12-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells.
AN  - 69012242; 18049996
AB  - With the development of nanotechnology, there is a tremendous growth of the application of nanomaterials, which increases the risk of human exposure to these nanomaterials through inhalation, ingestion, and dermal penetration. Among different types of nanoparticles, single-walled carbon nanotubes (SWCNT) with extremely small size (1 nm in diameter) exhibit extraordinary properties and offer possibilities to create materials with astounding features. Since the release of nanoparticles in an enclosed environment is of great concern, a study of possible genotoxic effects is important. Our previous data showed that pharyngeal aspiration of SWCNT elicited pulmonary effects in C57BL/6 mice that was promoted by a robust, acute inflammatory reaction with early onset resulting in progressive interstitial fibrogenic response and the formation of granulomas. In the present study, the genotoxic potential of SWCNT was evaluated in vitro. The genotoxic effects of nanoparticles were examined using three different test systems: the comet assay and micronucleus (MN) test in a lung fibroblast (V79) cell line, and the Salmonella gene mutation assay in strains YG1024/YG1029. Cytotoxicity tests showed loss of viability in a concentration- and time-dependent manner after exposure of cells to SWCNT. Results from the comet assay demonstrated the induction of DNA damage after only 3 h of incubation with 96 microg/cm2 of SWCNT. The MN test indicated some but not significant micronucleus induction by SWCNT in the V79 cell line at the highest concentrations tested. With two different strains of Salmonella typhimurium, no mutations were found following SWCNT exposure.
JF  - Journal of toxicology and environmental health. Part A
AU  - Kisin, Elena R
AU  - Murray, Ashley R
AU  - Keane, Michael J
AU  - Shi, Xiao-Chun
AU  - Schwegler-Berry, Diane
AU  - Gorelik, Olga
AU  - Arepalli, Sivaram
AU  - Castranova, Vincent
AU  - Wallace, William E
AU  - Kagan, Valerian E
AU  - Shvedova, Anna A
AD  - Pathology/Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA.
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 2071
EP  - 2079
VL  - 70
IS  - 24
SN  - 1528-7394, 1528-7394
KW  - Nanotubes, Carbon
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Mutagenicity Tests
KW  - Cricetulus
KW  - Cell Survival -- drug effects
KW  - DNA Damage
KW  - Lung -- cytology
KW  - Chromosome Aberrations
KW  - Salmonella typhimurium -- drug effects
KW  - Salmonella typhimurium -- genetics
KW  - Cell Line
KW  - Cricetinae
KW  - Fibroblasts -- drug effects
KW  - Fibroblasts -- cytology
KW  - Nanotubes, Carbon -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-18
N1  - Date created - 2007-11-30
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Drug interaction studies of therapeutic proteins or monoclonal antibodies.
AN  - 69003880; 17962422
AB  - Drug interactions can alter the pharmacokinetics and/or pharmacodynamics of a drug. In pharmacokinetic drug interactions, the concentrations of 1 or more drugs are altered by another. This change in concentration in a given drug may be due to changes in absorption, distribution, metabolism, or elimination. The pharmacodynamic interaction can lead to additive, synergistic, or antagonistic effects of a drug. Drug interaction studies are regularly conducted with conventional drugs (small molecules), but very few drug interaction studies have been performed with macromolecules (therapeutic proteins or monoclonal antibodies). This is mainly because most macromolecules are not metabolized by the cytochrome P450 system, and their mechanism of elimination is complex. However, it has been shown in several studies that interferons can have an impact on the cytochrome P450 system that may alter the pharmacokinetics and pharmacodynamics of a conventional drug when given with interferons. Therefore, it is important to evaluate the effect of other classes of macromolecules (cytokines, interleukins, monoclonal antibodies) on drug-metabolizing enzymes. It is also imperative that the effects of conventional drugs on the pharmacokinetics and pharmacodynamics of macromolecules be conducted. The present review encompasses several drug interaction studies that were conducted with macromolecules and highlights the impact of these studies on the pharmacokinetics and/or pharmacodynamics of the involved drugs.
JF  - Journal of clinical pharmacology
AU  - Mahmood, Iftekhar
AU  - Green, Martin David
AD  - Office of Blood Review & Research (OBRR), Center for Biologic Evaluation and Research, Food & Drug Administration, 1451 Rockville Pike, Rockville, MD 20850, USA. Iftekhar.mahmood@fda.hhs.gov
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 1540
EP  - 1554
VL  - 47
IS  - 12
SN  - 0091-2700, 0091-2700
KW  - Antibodies, Monoclonal
KW  - 0
KW  - Cytokines
KW  - Interleukins
KW  - Macromolecular Substances
KW  - Cytochrome P-450 Enzyme System
KW  - 9035-51-2
KW  - Index Medicus
KW  - Animals
KW  - Cytokines -- therapeutic use
KW  - Cytokines -- pharmacokinetics
KW  - Humans
KW  - Interleukins -- therapeutic use
KW  - Interleukins -- pharmacokinetics
KW  - Interleukins -- metabolism
KW  - Cytochrome P-450 Enzyme System -- metabolism
KW  - Cytokines -- metabolism
KW  - Macromolecular Substances -- pharmacokinetics
KW  - Drug Interactions
KW  - Antibodies, Monoclonal -- pharmacokinetics
KW  - Antibodies, Monoclonal -- metabolism
KW  - Macromolecular Substances -- metabolism
KW  - Macromolecular Substances -- therapeutic use
KW  - Antibodies, Monoclonal -- therapeutic use
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-03
N1  - Date created - 2007-11-30
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Lessons from the Avandia controversy: a new paradigm for the development of drugs to treat type 2 diabetes.
AN  - 68548960; 18042753
JF  - Diabetes care
AU  - Misbin, Robert I
AD  - Division of Endocrinology and Metabolism, Food and Drug Administration, Silver Spring, Maryland, USA. robert.misbin@fda.hhs.gov
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 3141
EP  - 3144
VL  - 30
IS  - 12
KW  - Hypoglycemic Agents
KW  - 0
KW  - Thiazolidinediones
KW  - rosiglitazone
KW  - 05V02F2KDG
KW  - Index Medicus
KW  - United States
KW  - Hypoglycemic Agents -- therapeutic use
KW  - United States Food and Drug Administration
KW  - Humans
KW  - Drug Approval
KW  - Hypoglycemic Agents -- adverse effects
KW  - Clinical Trials as Topic -- standards
KW  - Meta-Analysis as Topic
KW  - Diabetes Mellitus, Type 2 -- drug therapy
KW  - Thiazolidinediones -- adverse effects
KW  - Thiazolidinediones -- therapeutic use
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-08
N1  - Date created - 2007-11-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain.
AN  - 68538797; 17532111
AB  - Adenosine A2A receptors localized in the dorsal striatum are considered as a new target for the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists has shown a significant improvement of the effects of l-DOPA. The present review emphasizes the possible application of A2A receptor antagonists in pathological conditions other than parkinsonism, including drug addiction, sleep disorders and pain. In addition to the dorsal striatum, the ventral striatum (nucleus accumbens) contains a high density of A2A receptors, which presynaptically and postsynaptically regulate glutamatergic transmission in the cortical glutamatergic projections to the nucleus accumbens. It is currently believed that molecular adaptations of the cortico-accumbens glutamatergic synapses are involved in compulsive drug seeking and relapse. Here we review recent experimental evidence suggesting that A2A antagonists could become new therapeutic agents for drug addiction. Morphological and functional studies have identified lower levels of A2A receptors in brain areas other than the striatum, such as the ventrolateral preoptic area of the hypothalamus, where adenosine plays an important role in sleep regulation. Although initially believed to be mostly dependent on A1 receptors, here we review recent studies that demonstrate that the somnogenic effects of adenosine are largely mediated by hypothalamic A2A receptors. A2A)receptor antagonists could therefore be considered as a possible treatment for narcolepsy and other sleep-related disorders. Finally, nociception is another adenosine-regulated neural function previously thought to mostly involve A1 receptors. Although there is some conflicting literature on the effects of agonists and antagonists, which may partly be due to the lack of selectivity of available drugs, the studies in A2A receptor knockout mice suggest that A2A receptor antagonists might have some therapeutic potential in pain states, in particular where high intensity stimuli are prevalent.
JF  - Progress in neurobiology
AU  - Ferré, S
AU  - Diamond, I
AU  - Goldberg, S R
AU  - Yao, L
AU  - Hourani, S M O
AU  - Huang, Z L
AU  - Urade, Y
AU  - Kitchen, I
AD  - Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, Department of Health and Human Services, Baltimore, MD 21224, USA. sferre@intra.nida.nih.gov
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 332
EP  - 347
VL  - 83
IS  - 5
SN  - 0301-0082, 0301-0082
KW  - Adenosine A1 Receptor Antagonists
KW  - 0
KW  - Adenosine A2 Receptor Antagonists
KW  - Receptor, Adenosine A1
KW  - Receptor, Adenosine A2A
KW  - Adenosine
KW  - K72T3FS567
KW  - Index Medicus
KW  - Neural Pathways -- physiopathology
KW  - Animals
KW  - Receptor, Adenosine A1 -- metabolism
KW  - Neural Pathways -- metabolism
KW  - Humans
KW  - Neural Pathways -- drug effects
KW  - Adenosine -- metabolism
KW  - Substance-Related Disorders -- physiopathology
KW  - Pain -- drug therapy
KW  - Pain -- physiopathology
KW  - Hypothalamus -- drug effects
KW  - Sleep Wake Disorders -- metabolism
KW  - Hypothalamus -- physiopathology
KW  - Receptor, Adenosine A2A -- metabolism
KW  - Sleep Wake Disorders -- physiopathology
KW  - Sleep Wake Disorders -- drug therapy
KW  - Hypothalamus -- metabolism
KW  - Substance-Related Disorders -- drug therapy
KW  - Basal Ganglia -- physiopathology
KW  - Substance-Related Disorders -- metabolism
KW  - Basal Ganglia -- drug effects
KW  - Pain -- metabolism
KW  - Basal Ganglia -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-04
N1  - Date created - 2007-11-21
N1  - Date revised - 2017-01-13
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N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Fatal falls overboard on commercial fishing vessels in Alaska.
AN  - 68531288; 17910031
AB  - Falls overboard are a major contributor to commercial fishing fatalities in Alaska. The National Institute for Occupational Safety and Health has repeatedly identified falls overboard as a critical issue in commercial fishing safety. This article describes the problem of falls overboard and discusses possible ways to reduce the risk factors.
          Data from the Alaska Occupational Injury Surveillance System on fatal falls overboard in Alaska between 1990 and 2005 were used. An in-depth descriptive analysis of these fatalities was performed to identify areas for intervention. There were 71 fatal falls overboard on commercial fishing vessels in Alaska during the 16-year time period. Falls overboard did not decline significantly during those years. The most common circumstances associated with falling overboard were working with fishing gear, being alone on deck, losing balance or slipping, heavy weather, gear entanglement, and alcohol. The level of involvement of those circumstances varied by region and gear type.
          Many fatal falls overboard may be prevented by understanding the circumstances involved and targeting interventions at those specific risk factors. Interventions include creating more enclosed work spaces, managing lines, avoiding fishing alone, wearing personal flotation devices and man overboard alarms, and reducing alcohol use. Subsequent research should identify further interventions for each circumstance and evaluate the effectiveness of these interventions with the fishing industry.
JF  - American journal of industrial medicine
AU  - Lucas, Devin L
AU  - Lincoln, Jennifer M
AD  - National Institute for Occupational Safety and Health, Alaska Field Station, Anchorage, Alaska 99508, USA. dlucas@cdc.gov
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 962
EP  - 968
VL  - 50
IS  - 12
SN  - 0271-3586, 0271-3586
KW  - Index Medicus
KW  - Epidemiologic Studies
KW  - Risk Factors
KW  - Humans
KW  - Alaska -- epidemiology
KW  - Adult
KW  - Incidence
KW  - Middle Aged
KW  - Male
KW  - Female
KW  - Ships
KW  - Drowning -- epidemiology
KW  - Occupational Health
KW  - Drowning -- etiology
KW  - Accidental Falls -- mortality
KW  - Fisheries -- statistics & numerical data
KW  - Drowning -- mortality
KW  - Accidents, Occupational -- statistics & numerical data
KW  - Accidental Falls -- statistics & numerical data
KW  - Accidents, Occupational -- mortality
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68531288?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Fatal+falls+overboard+on+commercial+fishing+vessels+in+Alaska.&rft.au=Lucas%2C+Devin+L%3BLincoln%2C+Jennifer+M&rft.aulast=Lucas&rft.aufirst=Devin&rft.date=2007-12-01&rft.volume=50&rft.issue=12&rft.spage=962&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-20
N1  - Date created - 2007-11-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin.
AN  - 68530329; 17875604
AB  - The cystine-glutamate transporter SLC7A11 has been implicated in chemoresistance, by supplying cystine to the cell for glutathione maintenance. In the NCI-60 cell panel, SLC7A11 expression shows negative correlation with growth inhibitory potency of geldanamycin but not with its analog 17-(allylamino)-17-demethoxygeldanamycin (17-AAG), which differs in the C-17 substituent in that the the methoxy moiety of geldanamycin is replaced by an amino group. Structure and potency analysis classified 18 geldanamycin analogs into two subgroups, "17-O/H" (C-17 methoxy or unsubstituted) and "17-N" (C-17 amino), showing distinct SLC7A11 correlation. We used three 17-O/H analogs and four 17-N analogs to test the role of the 17-substituents in susceptibility to SLC7A11-mediated resistance. In A549 cells, which are resistant to geldanamycin and strongly express SLC7A11, inhibition of SLC7A11 by (S)-4-carboxyphenylglycine or small interfering RNA increased sensitivity to 17-O/H, but had no effect on 17-N analogs. Ectopic expression of SLC7A11 in HepG2 cells, which are sensitive to geldanamycin and express low SLC7A11, confers resistance to geldanamycin, but not to 17-AAG. Antioxidant N-acetylcysteine, a precursor for glutathione synthesis, completely suppressed cytotoxic effects of 17-O/H but had no effect on 17-N analogs, whereas the prooxidant ascorbic acid had the opposite effect. Compared with 17-AAG, geldanamycin led to significantly more intracellular reactive oxygen species (ROS) production, which was quenched by addition of N-acetylcysteine. We conclude that SLC7A11 confers resistance selectively to 17-O/H (e.g., geldanamycin) but not to 17-N (e.g., 17-AAG) analogs partly as a result of differential dependence on ROS for cytotoxicity. Distinct mechanisms could significantly affect antitumor response and organ toxicity of these compounds in vivo.
JF  - Molecular pharmacology
AU  - Liu, Ruqing
AU  - Blower, Paul E
AU  - Pham, Anh-Nhan
AU  - Fang, Jialong
AU  - Dai, Zunyan
AU  - Wise, Carolyn
AU  - Green, Bridgette
AU  - Teitel, Candee H
AU  - Ning, Baitang
AU  - Ling, Wenhua
AU  - Lyn-Cook, Beverly D
AU  - Kadlubar, Fred F
AU  - Sadée, Wolfgang
AU  - Huang, Ying
AD  - Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA.
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 1637
EP  - 1646
VL  - 72
IS  - 6
KW  - Amino Acid Transport System y+
KW  - 0
KW  - Benzoquinones
KW  - Lactams, Macrocyclic
KW  - SLC7A11 protein, human
KW  - tanespimycin
KW  - 4GY0AVT3L4
KW  - geldanamycin
KW  - Z3K3VJ16KU
KW  - Index Medicus
KW  - Humans
KW  - Cell Line, Tumor
KW  - Drug Screening Assays, Antitumor -- methods
KW  - Structure-Activity Relationship
KW  - Benzoquinones -- chemistry
KW  - Benzoquinones -- pharmacology
KW  - Lactams, Macrocyclic -- chemistry
KW  - Amino Acid Transport System y+ -- metabolism
KW  - Lactams, Macrocyclic -- pharmacology
KW  - Drug Resistance, Neoplasm -- physiology
KW  - Drug Resistance, Neoplasm -- drug effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Cystine-glutamate+transporter+SLC7A11+mediates+resistance+to+geldanamycin+but+not+to+17-%28allylamino%29-17-demethoxygeldanamycin.&rft.au=Liu%2C+Ruqing%3BBlower%2C+Paul+E%3BPham%2C+Anh-Nhan%3BFang%2C+Jialong%3BDai%2C+Zunyan%3BWise%2C+Carolyn%3BGreen%2C+Bridgette%3BTeitel%2C+Candee+H%3BNing%2C+Baitang%3BLing%2C+Wenhua%3BLyn-Cook%2C+Beverly+D%3BKadlubar%2C+Fred+F%3BSad%C3%A9e%2C+Wolfgang%3BHuang%2C+Ying&rft.aulast=Liu&rft.aufirst=Ruqing&rft.date=2007-12-01&rft.volume=72&rft.issue=6&rft.spage=1637&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=1521-0111&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-04
N1  - Date created - 2007-11-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Drug interactions in the management of HIV infection: an update.
AN  - 68516515; 18001255
AB  - Improvement in the availability of antiretroviral (ARV) therapy continues to reduce HIV morbidity and mortality. With more treatment choices and better accessibility, the extent of medication use among patients with HIV/AIDS continues to grow. ARV drugs are particularly prone to drug interactions as a consequence of their metabolic and pharmacokinetic properties. The recognition and management of drug interactions in patients on ARVs is a constant challenge to medical providers. Staying abreast of drug interaction knowledge is complicated by the rate at which new information becomes available through in vivo investigation, case reports and pharmacokinetic studies. In addition, distinguishing the clinical significance of an interaction is difficult due to the large interpatient variability in pharmacokinetics exhibited by most ARV agents. This review provides an update to a previous review article published in 2005, and is intended to improve the reader's knowledge of drug interactions in the management of HIV infection.
JF  - Expert opinion on pharmacotherapy
AU  - Robertson, Sarah M
AU  - Penzak, Scott R
AU  - Pau, Alice
AD  - US Food and Drug Administration, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Silver Spring, Maryland, USA.
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 2947
EP  - 2963
VL  - 8
IS  - 17
KW  - Anti-HIV Agents
KW  - 0
KW  - HIV Protease Inhibitors
KW  - Reverse Transcriptase Inhibitors
KW  - Index Medicus
KW  - Humans
KW  - Drug Monitoring
KW  - Treatment Outcome
KW  - Drug Interactions
KW  - Anti-HIV Agents -- pharmacokinetics
KW  - Reverse Transcriptase Inhibitors -- pharmacokinetics
KW  - Anti-HIV Agents -- therapeutic use
KW  - HIV Infections -- drug therapy
KW  - HIV Infections -- metabolism
KW  - HIV Protease Inhibitors -- pharmacokinetics
KW  - HIV Protease Inhibitors -- therapeutic use
KW  - Reverse Transcriptase Inhibitors -- therapeutic use
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-20
N1  - Date created - 2007-11-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha.
AN  - 68473195; 17586532
AB  - Peroxisome proliferators are potent rodent liver carcinogens that act via a non-genotoxic mechanism. The mode of action of these agents in rodent liver includes increased cell proliferation, decreased apoptosis, secondary oxidative stress and other events; however, it is not well understood how peroxisome proliferators are triggering the plethora of the molecular signals leading to cancer. Epigenetic changes have been implicated in the mechanism of liver carcinogenesis by a number of environmental agents. Short-term treatment with peroxisome proliferators and other non-genotoxic carcinogens leads to global and locus-specific DNA hypomethylation in mouse liver, events that were suggested to correlate with a burst of cell proliferation. In the current study, we investigated the effects of long-term exposure to a model peroxisome proliferator WY-14,643 on DNA and histone methylation. Male SV129mice were fed a control or WY-14,643-containing (1000ppm) diet for one week, five weeks or five months. Treatment with WY-14,643 led to progressive global hypomethylation of liver DNA as determined by an HpaII-based cytosine extension assay with the maximum effect reaching over 200% at five months. Likewise, trimethylation of histone H4 lysine 20 and H3 lysine 9 was significantly decreased at all time points. The majority of cytosine methylation in mammals resides in repetitive DNA sequences. In view of this, we measured the effect of WY-14,643 on the methylation status of major and minor satellites, as well as in IAP, LINE1 and LINE2 elements in liver DNA. Exposure to WY-14,643 resulted in a gradual loss of cytosine methylation in major and minor satellites, IAP, LINE1 and LINE2 elements. The epigenetic changes correlated with the temporal effects of WY-14,643 on cell proliferation rates in liver, but no sustained effect on c-Myc promoter methylation was observed. Finally, WY-14,643 had no effect on DNA and histone methylation status in Pparalpha-null mice at any of the time points considered in this study. These data indicate the importance of epigenetic alterations in the mechanism of action of peroxisome proliferators and the key role of Pparalpha.
JF  - Mutation research
AU  - Pogribny, Igor P
AU  - Tryndyak, Volodymyr P
AU  - Woods, Courtney G
AU  - Witt, Sarah E
AU  - Rusyn, Ivan
AD  - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA.
Y1  - 2007/12/01/
PY  - 2007
DA  - 2007 Dec 01
SP  - 62
EP  - 71
VL  - 625
IS  - 1-2
SN  - 0027-5107, 0027-5107
KW  - Carcinogens
KW  - 0
KW  - DNA Primers
KW  - Histones
KW  - PPAR alpha
KW  - Peroxisome Proliferators
KW  - Pyrimidines
KW  - Retroelements
KW  - pirinixic acid
KW  - 86C4MRT55A
KW  - Index Medicus
KW  - Animals
KW  - Base Sequence
KW  - Terminal Repeat Sequences -- drug effects
KW  - DNA Primers -- genetics
KW  - Histones -- metabolism
KW  - DNA Methylation -- drug effects
KW  - CpG Islands -- drug effects
KW  - Carcinogens -- toxicity
KW  - Retroelements -- drug effects
KW  - Long Interspersed Nucleotide Elements -- drug effects
KW  - Mice
KW  - Male
KW  - Mice, Knockout
KW  - PPAR alpha -- deficiency
KW  - Epigenesis, Genetic -- physiology
KW  - Liver -- drug effects
KW  - Pyrimidines -- toxicity
KW  - Peroxisome Proliferators -- toxicity
KW  - Epigenesis, Genetic -- drug effects
KW  - Liver -- metabolism
KW  - PPAR alpha -- metabolism
KW  - PPAR alpha -- genetics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-13
N1  - Date created - 2007-11-05
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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Carcinogenesis. 2006 Aug;27(8):1713-20 [16632870]
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Anal Biochem. 2006 Sep 15;356(2):202-7 [16824473]
Crit Rev Toxicol. 2006 May;36(5):459-79 [16954067]
J Nutr. 2007 Jan;137(1 Suppl):216S-222S [17182829]
Cancer Res. 2007 Feb 1;67(3):946-50 [17283125]
Mol Carcinog. 2007 Mar;46(3):187-97 [17219426]
Toxicol Sci. 2007 Aug;98(2):366-74 [17483499]
Regul Toxicol Pharmacol. 2000 Oct;32(2):135-43 [11067770]
Carcinogenesis. 2000 Dec;21(12):2141-5 [11133801]
Antioxid Redox Signal. 2000 Fall;2(3):607-21 [11229371]
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Toxicol Sci. 2001 Jul;62(1):28-35 [11399790]
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Adv Cancer Res. 2003;90:209-30 [14710952]
Crit Rev Toxicol. 2003;33(6):655-780 [14727734]
EMBO J. 2004 Feb 11;23(3):605-15 [14765126]
Science. 2004 Mar 12;303(5664):1626-32 [15016989]
J Cell Sci. 2004 May 15;117(Pt 12):2491-501 [15128874]
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Mol Cell Biol. 1995 Jun;15(6):3012-22 [7539101]
Cancer Res. 1997 Feb 15;57(4):594-9 [9044832]
Mutat Res. 1997 Apr;386(2):141-52 [9113115]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Uncertainty determination for nondestructive chemical analytical methods using field data and application to XRF analysis for lead.
AN  - 68428524; 17957563
AB  - Air sampling and analytical methods are developed to provide a basis for decision making. They are evaluated in the laboratory against prescribed fitness-for-use criteria even though laboratory validation does not take into account all possible sources of uncertainty in field application. Field evaluation would be preferable but is complicated by the lack of controlled conditions, which limits the ability to compare analytical methods and to recognize outliers and assess variance homogeneity across the range of interest. The specific situation of evaluating nondestructive field analytical methods against their reference laboratory equivalent is considered here, since the difficulty of providing replicates is obviated in this case. A portable X-ray fluorescence (XRF) analyzer was used to determine the lead content of air filter samples from several workplaces where lead is used or is a contaminant of the process material. The portable XRF method has the advantage of allowing for faster decisions compared with the alternative of submitting the air samples to an off-site laboratory for analysis. Since the XRF method is nondestructive, the same air samples were also subjected to the reference laboratory-based method of analysis. Two statistical approaches were developed specifically to deal with non-normal elements of the data in evaluating the results. The ISO GUM method identifies outliers and then calculates an accuracy range about the true concentration for the remainder of the data. This coverage is then adjusted to account for the rate of outlier occurrence. The bootstrap procedure uses a large number of computer-generated data points that are sampled, with replacement, from the original set including outliers to determine the coverage. No significant difference is seen between the two statistical approaches. Both approaches result in similar coverage and support the adoption of method acceptance criteria specific to field evaluation (a symmetric accuracy range of 35%). The portable XRF analyzer met this criterion when used with several different sampling methods and thus could be used as a method for routine evaluation of compliance with lead limit values. As the method is nondestructive, further analysis of air samples with analytical results near decision points is possible.
JF  - Journal of occupational and environmental hygiene
AU  - Bartley, David L
AU  - Slaven, James E
AU  - Rose, Mike C
AU  - Andrew, Michael E
AU  - Harper, Martin
AD  - National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 931
EP  - 942
VL  - 4
IS  - 12
SN  - 1545-9624, 1545-9624
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Lead
KW  - 2P299V784P
KW  - Index Medicus
KW  - Threshold Limit Values
KW  - Sensitivity and Specificity
KW  - Humans
KW  - Confidence Intervals
KW  - Metallurgy
KW  - Spectrometry, X-Ray Emission -- instrumentation
KW  - Air Pollutants, Occupational -- analysis
KW  - Lead -- analysis
KW  - Occupational Exposure -- analysis
KW  - Environmental Monitoring -- methods
KW  - Environmental Monitoring -- instrumentation
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-31
N1  - Date created - 2007-10-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Identification and characterization of potential sources of worker exposure to carbon nanofibers during polymer composite laboratory operations.
AN  - 68417358; 17943583
JF  - Journal of occupational and environmental hygiene
AU  - Methner, Mark M
AU  - Birch, M Eileen
AU  - Evans, Douglas E
AU  - Ku, Bon-Ki
AU  - Crouch, Keith
AU  - Hoover, Mark D
AD  - National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - D125
EP  - D130
VL  - 4
IS  - 12
SN  - 1545-9624, 1545-9624
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Particulate Matter
KW  - Carbon
KW  - 7440-44-0
KW  - Index Medicus
KW  - Protective Clothing
KW  - Manufactured Materials -- analysis
KW  - Humans
KW  - Environmental Exposure
KW  - Occupational Exposure -- analysis
KW  - Risk Assessment
KW  - Air Pollutants, Occupational -- analysis
KW  - Metal Nanoparticles -- analysis
KW  - Carbon -- analysis
KW  - Particulate Matter -- analysis
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Identification+and+characterization+of+potential+sources+of+worker+exposure+to+carbon+nanofibers+during+polymer+composite+laboratory+operations.&rft.au=Methner%2C+Mark+M%3BBirch%2C+M+Eileen%3BEvans%2C+Douglas+E%3BKu%2C+Bon-Ki%3BCrouch%2C+Keith%3BHoover%2C+Mark+D&rft.aulast=Methner&rft.aufirst=Mark&rft.date=2007-12-01&rft.volume=4&rft.issue=12&rft.spage=D125&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-31
N1  - Date created - 2007-10-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The Nanoparticle Information Library (NIL): a prototype for linking and sharing emerging data.
AN  - 68364845; 17924276
JF  - Journal of occupational and environmental hygiene
AU  - Miller, Arthur L
AU  - Hoover, Mark D
AU  - Mitchell, David M
AU  - Stapleton, Brian P
AD  - National Institute for Occupational Safety and Health, Spokane, WA, USA.
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - D131
EP  - D134
VL  - 4
IS  - 12
SN  - 1545-9624, 1545-9624
KW  - Index Medicus
KW  - United States
KW  - Registries
KW  - Cooperative Behavior
KW  - Humans
KW  - Information Dissemination
KW  - Databases, Factual
KW  - Manufactured Materials
KW  - Information Storage and Retrieval
KW  - Internet
KW  - Nanoparticles -- statistics & numerical data
KW  - Libraries
KW  - Nanoparticles -- adverse effects
KW  - National Institute for Occupational Safety and Health (U.S.)
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-31
N1  - Date created - 2007-10-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Chronic lymphocytic leukemia radiogenicity: a systematic review.
AN  - 68332371; 17694421
AB  - Chronic lymphocytic leukemia (CLL) is generally considered to be non-radiogenic and is excluded from several programs that compensate workers for illnesses resulting from occupational exposures. Questions about whether this exclusion is justified prompted a Congressional mandate to the National Institute for Occupational Safety and Health (NIOSH) to, further, examine the radiogenicity of CLL. This study revisits the question of CLL radiogenicity by examining epidemiologic evidence from occupationally and medically-exposed populations.
          A systematic review of radiation-exposed cohorts was conducted to investigate the association between radiation and CLL. Exploratory power calculations for a pooled occupational study were performed to examine the feasibility of assessing CLL radiogenicity epidemiologically. There is a bias against reporting CLL results, because of the disease's presumed non-radiogenicity. In medical cohort studies that provide risk estimates for CLL, risk is elevated, though non-significantly, in almost all studies with more than 15 years average follow-up. The results of occupational studies are less consistent.
          Studies with adequate follow-up time and power are needed to better understand CLL radiogenicity. Power analyses show that a pooled study might detect risk on the order of radiation induced non-CLL leukemia, but is unlikely to detect smaller risks.
JF  - Cancer causes & control : CCC
AU  - Silver, Sharon R
AU  - Hiratzka, Shannon L
AU  - Schubauer-Berigan, Mary K
AU  - Daniels, Robert D
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, USA. ssilver@cdc.gov
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 1077
EP  - 1093
VL  - 18
IS  - 10
SN  - 0957-5243, 0957-5243
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - National Institute for Occupational Safety and Health (U.S.)
KW  - Leukemia, Lymphocytic, Chronic, B-Cell -- epidemiology
KW  - Neoplasms, Radiation-Induced -- epidemiology
KW  - Occupational Exposure -- adverse effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Chronic+lymphocytic+leukemia+radiogenicity%3A+a+systematic+review.&rft.au=Silver%2C+Sharon+R%3BHiratzka%2C+Shannon+L%3BSchubauer-Berigan%2C+Mary+K%3BDaniels%2C+Robert+D&rft.aulast=Silver&rft.aufirst=Sharon&rft.date=2007-12-01&rft.volume=18&rft.issue=10&rft.spage=1077&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=09575243&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-11
N1  - Date created - 2007-10-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Spousal concordance for substance use and anxiety disorders.
AN  - 68182937; 17204289
AB  - Assortative mating -- the tendency for mate selection to occur on the basis of similar traits -- plays an essential role in understanding the genetic contribution to psychiatric illness. It also carries significant impact on clinical prognosis and is an important mechanism explaining spousal concordance. This study uses a family study design ascertaining 225 probands with substance abuse/dependence, anxiety disorders, and controls to address: (1) Is there spousal concordance or cross-concordance for substance use and/or anxiety disorders? (2) Is the spousal concordance or cross-concordance associated with worse clinical outcomes? (3) What is the mechanism of the concordance or cross-concordance? Results show a high magnitude of spousal concordance for substance use disorders with a third of the substance probands' spouses also substance dependent. In contrast, there was no spousal concordance for anxiety disorders. Couples were also concordant for having "no disorders." Both substance use and anxiety disorder concordance were associated with poorer global functioning and persistent illness. Assortative mating is a likely mechanism for spousal concordance given the elevated rate of substance use disorders among the relatives of spouses' of substance probands. Implications for family/genetic studies and the transmission of substance use disorders and "no disorders" include: (1) at the individual level, spousal concordance influences probands' course of illness, couples' marital functioning, and offspring's genetic and environmental context; and (2) at the population level, it shifts the general distribution of substance use disorders and "no disorders" by reducing the "average" couple concordance and increasing the number concordant and discordant couples at extremes of the distribution.
JF  - Journal of psychiatric research
AU  - Low, Nancy
AU  - Cui, Lihong
AU  - Merikangas, Kathleen R
AD  - Section on Developmental Genetic Epidemiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-3720, USA. Nancy.Low@nih.gov
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 942
EP  - 951
VL  - 41
IS  - 11
SN  - 0022-3956, 0022-3956
KW  - Index Medicus
KW  - Humans
KW  - Marriage -- statistics & numerical data
KW  - Comorbidity
KW  - Mood Disorders -- genetics
KW  - Phenotype
KW  - Interview, Psychological
KW  - Marriage -- psychology
KW  - Genetic Predisposition to Disease -- genetics
KW  - Risk Factors
KW  - Adult
KW  - Middle Aged
KW  - Mood Disorders -- epidemiology
KW  - Mood Disorders -- psychology
KW  - Female
KW  - Male
KW  - Anxiety Disorders -- genetics
KW  - Alcoholism -- epidemiology
KW  - Anxiety Disorders -- psychology
KW  - Spouses -- statistics & numerical data
KW  - Spouses -- psychology
KW  - Substance-Related Disorders -- psychology
KW  - Anxiety Disorders -- epidemiology
KW  - Alcoholism -- genetics
KW  - Alcoholism -- psychology
KW  - Substance-Related Disorders -- genetics
KW  - Substance-Related Disorders -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-30
N1  - Date created - 2007-08-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Understanding the Relative Influence of Neighborhood, Family, and Youth on Adolescent Drug Use
AN  - 61432843; 200804746
AB  - In the United States, a variety of programs have been developed to prevent substance use among youth. These programs often target youth directly, and may also have components that address the relational influence of families, schools, and communities. We discuss clustering of youth marijuana use within and between households and neighborhoods. As often discussed in the literature, we consider analyzing 'components of variance' in a hierarchical sample design with two or more levels. With a continuous outcome variable, the estimated relative size of variance components at each level can be interpreted as its relative 'importance.' We estimate variance components when the outcome is dichotomous, and find that for the use of marijuana in the past year, the role of the individual (individual adolescent vs. role of household vs. role of neighborhood) is quite prominent (79% of variation). A similar result is observed for the continuous scale variable of individual positive attitudes toward drug use (83%). For continuous constructs related to either household (parental monitoring) or neighborhood (neighborhood disorganization) the majority of variation still occurs at the individual level (67% and 51%, respectively), although they reveal significant percent variation (about 30%) at the corresponding family or neighborhood levels as well. We discuss the use of variance component methodology and the relevance for prevention programs. Adapted from the source document.
JF  - Substance Use & Misuse
AU  - Wright, Douglas A
AU  - Bobashev, Georgiy
AU  - Folsom, Ralph
AD  - Office of Applied Studies (OAS), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, Maryland, USA
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 2159
EP  - 2171
PB  - Taylor & Francis, Philadelphia PA
VL  - 42
IS  - 14
SN  - 1082-6084, 1082-6084
KW  - Prevention
KW  - Substance Abuse
KW  - Family Relations
KW  - United States of America
KW  - Marijuana
KW  - article
KW  - 6129: addiction
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61432843?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Understanding+the+Relative+Influence+of+Neighborhood%2C+Family%2C+and+Youth+on+Adolescent+Drug+Use&rft.au=Wright%2C+Douglas+A%3BBobashev%2C+Georgiy%3BFolsom%2C+Ralph&rft.aulast=Wright&rft.aufirst=Douglas&rft.date=2007-12-01&rft.volume=42&rft.issue=14&rft.spage=2159&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1080%2F10826080701212675
LA  - English
DB  - Social Services Abstracts
N1  - Date revised - 2008-09-03
N1  - Number of references - 22
N1  - Last updated - 2016-09-28
N1  - CODEN - SUMIFL
N1  - SubjectsTermNotLitGenreText - Marijuana; Family Relations; United States of America; Substance Abuse; Prevention
DO  - http://dx.doi.org/10.1080/10826080701212675
ER  - 



TY  - JOUR
T1  - Crossing the Line: Observations from East Detroit, Michigan, USA
AN  - 61420955; 200907042
AB  - This is an experimental piece that reports on findings from a research project conducted from September to December 2006 on the border between a neighborhood on the east side of Detroit (Jefferson Chalmers) and Grosse Pointe Park, Michigan. The project addresses the stark racial, economic, and physical divides between two proximate communities, and the way that the boundary line between these communities is enacted. Alter Road, serves as this real and infrequently crossed border. The physical barriers put in place to reinforce the imaginary line between East Detroit,1 and Grosse Pointe Park and the conditions on either side of the border are prominent themes. For social workers, understanding how and why bordering communities remain insular, and the effect of that segregation, is important in understanding human behavior and better appreciating the circumstances from which people come. This qualitative piece illustrates these issues through the eyes of a graduate social work student walking again and again across that boundary. [Reprinted by permission of Sage Publications Ltd., copyright 2007.]
JF  - Qualitative Social Work
AU  - Martin, Megan C
AD  - Department of Health and Human Services, Washington, DC, USA megcmartin@gmail.com
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 465
EP  - 475
PB  - Sage Publications, London UK
VL  - 6
IS  - 4
SN  - 1473-3250, 1473-3250
KW  - borders neighborhood observational research race
KW  - Borders
KW  - Neighborhoods
KW  - Race
KW  - Detroit, Michigan
KW  - article
KW  - 6111: social work theory/research
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61420955?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Social+Work&rft.atitle=Crossing+the+Line%3A+Observations+from+East+Detroit%2C+Michigan%2C+USA&rft.au=Martin%2C+Megan+C&rft.aulast=Martin&rft.aufirst=Megan&rft.date=2007-12-01&rft.volume=6&rft.issue=4&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Qualitative+Social+Work&rft.issn=14733250&rft_id=info:doi/10.1177%2F1473325007083357
LA  - English
DB  - Social Services Abstracts
N1  - Date revised - 2009-10-02
N1  - Number of references - 4
N1  - Last updated - 2016-09-28
N1  - SubjectsTermNotLitGenreText - Detroit, Michigan; Race; Neighborhoods; Borders
DO  - http://dx.doi.org/10.1177/1473325007083357
ER  - 



TY  - JOUR
T1  - Selection into specialty training in public health: performance of the Medical Training Application Service shortlisting
AN  - 57253381; 200816438
AB  - Objective: To assess the performance of shortlisting against appointability to public health specialty training under the Medical Training Application Service (MTAS) selection methodology using multiple modality in person assessment. Methods: Candidates who had applied to public health specialty training programme in Wales and East of England and shortlisted were assessed in the first assessment round. Further to MTAS review, candidates not previously short listed were offered assessment in the second round. Receiver operating characteristic (ROC) analysis was done. Results: In both the programmes, the shortlisting scores of candidates considered appointable were substantially higher than those considered not appointable, a score difference of 13.0 (95% confidence interval (CI) 3.0-23.0) and 13.5 (95% CI 3.4-23.5) respectively. The area under the ROC curve (ROCAUC) was 0.88 (95% CI 0.63-1.00) in Wales and 0.77 (95% CI 0.57-0.97) in East of England. The shortlisting scores of the two programmes that gave an optimum performance (maximum sum of the sensitivity and specificity) were comparable (scores of 62 and 63 respectively). Conclusion: MTAS shortlisting undertaken in two independent public health specialty training programmes discriminated well between appointable and not appointable candidates. Adapted from the source document.
JF  - Journal of Public Health
AU  - Pashayan, Nora
AU  - Duff, Celia
AU  - Mason, Brendan W
AD  - National Public Health Service for Wales, The Temple of Peace and Health, Cathays Parks, Cardiff CF10 3NW, UK
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 331
EP  - 337
PB  - Oxford University Press
VL  - 29
IS  - 4
SN  - 1741-3842, 1741-3842
KW  - medical training application service (MTAS), specialty training, postgraduate medical education, assessment centre, receiver operating characteristic analysis
KW  - Assessment
KW  - Receiver operating characteristic analysis
KW  - Training
KW  - Application
KW  - Specialization
KW  - Medical education
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253381?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health&rft.atitle=Selection+into+specialty+training+in+public+health%3A+performance+of+the+Medical+Training+Application+Service+shortlisting&rft.au=Pashayan%2C+Nora%3BDuff%2C+Celia%3BMason%2C+Brendan+W&rft.aulast=Pashayan&rft.aufirst=Nora&rft.date=2007-12-01&rft.volume=29&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health&rft.issn=17413842&rft_id=info:doi/10.1093%2Fpubmed%2Ffdm060
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-08-04
N1  - Last updated - 2016-09-27
N1  - SubjectsTermNotLitGenreText - Receiver operating characteristic analysis; Specialization; Training; Medical education; Assessment; Application
DO  - http://dx.doi.org/10.1093/pubmed/fdm060
ER  - 



TY  - JOUR
T1  - Needle-stick injuries in primary care in Wales
AN  - 57251116; 200815765
AB  - Background: Accidental needle-stick injuries (NSIs) are a hazard for health-care workers and for the general public. Objectives: To estimate the presentation rate of NSIs to general medical practices, their relation to practice characteristics, and review practice policies for managing NSIs. Method: Descriptive study using logistic regression analysis. Results: Annual rates of 2.73 (95% CI 2.08, 3.50) occupational NSIs per 100 clinical practice staff and 2.14 (95% CI 1.39, 3.13) non-occupational NSIs per 100 000 practice population were recorded. Stepwise logistic regressions showed that chance of a practice reporting at least one occupational NSI in previous five years was best predicted by being a single-handed practice (decreased odds). In contrast, the chance of a practice reporting at least one non-occupational NSI was best predicted by being a rural practice (increased odds). About one in five practices possessed no written policy on managing NSIs. Stepwise logistic regressions showed that the chance of a practice owning a NSI policy was best predicted by being located in an LHB area with a coastline (increased odds). Conclusion: NSIs are an important public health issue in Wales. We have tried to address the lack of guidance by developing new guidelines in Wales. Adapted from the source document.
JF  - Journal of Public Health
AU  - Atenstaedt, R L
AU  - Payne, S
AU  - Roberts, R J
AU  - Russell, I T
AU  - Russell, D
AU  - Edwards, R T
AD  - National Public Health Service for Wales, UK robert.atenstaedt@nphs.wales.nhs.uk
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 434
EP  - 440
PB  - Oxford University Press
VL  - 29
IS  - 4
SN  - 1741-3842, 1741-3842
KW  - general practice, needle-stick injury, primary care, public health
KW  - Needles
KW  - Penetrating injuries
KW  - General practice
KW  - Primary health care
KW  - Wales
KW  - Public health
KW  - article
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health&rft.atitle=Needle-stick+injuries+in+primary+care+in+Wales&rft.au=Atenstaedt%2C+R+L%3BPayne%2C+S%3BRoberts%2C+R+J%3BRussell%2C+I+T%3BRussell%2C+D%3BEdwards%2C+R+T&rft.aulast=Atenstaedt&rft.aufirst=R&rft.date=2007-12-01&rft.volume=29&rft.issue=4&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health&rft.issn=17413842&rft_id=info:doi/10.1093%2Fpubmed%2Ffdm048
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-08-04
N1  - Last updated - 2016-09-27
N1  - SubjectsTermNotLitGenreText - Public health; Wales; Needles; Primary health care; General practice; Penetrating injuries
DO  - http://dx.doi.org/10.1093/pubmed/fdm048
ER  - 



TY  - JOUR
T1  - Occupational and Non-Occupational Injuries in the United States Army: Focus on Gender
AN  - 57231500; 200805319
AB  - Background The differences in occupational and non-occupational injuries between military men and women have not been documented. This study compares occupational and non-occupational injuries between male and female United States Army soldiers by examining injury hospitalization rates and characteristics. Methods The U.S. Army's Total Army Injury and Health Outcomes Database was searched for hospitalizations with ICD-9-CM codes for injury (800-959.9) between 1992 and 2002. Injury rates were calculated using yearly U.S. Army population data and compared using rate ratios. Injury characteristics were compared among categories of the Trauma Code (on duty; off duty; scheduled training, schemes, and exercises), stratified by gender. Results Included in this analysis were 792 women for an injury hospitalization rate of 11.0 per 1000 individuals (95% confidence interval [CI]=8.5-13.5) and 4879 men for a rate of 15.5 per 1000 individuals (95% CI=14.0-16.9). While women had significantly more injuries during scheduled training, schemes, and exercises than men (p<0.0001), there were few differences in the cause of those injuries. Women had longer average hospital stays compared to men due to these injuries (9.3 days vs 7.4 days, p=0.002), although these injuries were not more severe (average Injury Severity Score=3.5 for men vs average ISS for women=3.5, p=0.79). There was no difference between the genders in the percent of injuries that occurred off duty; however, men were more likely to get injured due to sports and athletics (p=0.001) and due to fighting (p=0.017) while off duty compared to women. Conclusions Injury prevention messages for military personnel should focus on reducing risk factors for both on- and off-duty injuries. [Copyright 2007 American Journal of Preventive Medicine; published by Elsevier Inc.]
JF  - American Journal of Preventive Medicine
AU  - Tiesman, Hope M
AU  - Peek-Asa, Corinne L
AU  - Zwerling, Craig S
AU  - Sprince, Nancy L
AU  - Amoroso, Paul J
AD  - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia htiesman@cdc.gov
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 464
EP  - 470
PB  - Elsevier Science, New York NY
VL  - 33
IS  - 6
SN  - 0749-3797, 0749-3797
KW  - Hospitalization
KW  - Injuries
KW  - Industrial accidents
KW  - Soldiers
KW  - Out of working hours
KW  - Gender differences
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57231500?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Occupational+and+Non-Occupational+Injuries+in+the+United+States+Army%3A+Focus+on+Gender&rft.au=Tiesman%2C+Hope+M%3BPeek-Asa%2C+Corinne+L%3BZwerling%2C+Craig+S%3BSprince%2C+Nancy+L%3BAmoroso%2C+Paul+J&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2007-12-01&rft.volume=33&rft.issue=6&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2007.07.034
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-03-04
N1  - Last updated - 2016-09-27
N1  - CODEN - AJPMEA
N1  - SubjectsTermNotLitGenreText - Industrial accidents; Injuries; Soldiers; Gender differences; Out of working hours; Hospitalization
DO  - http://dx.doi.org/10.1016/j.amepre.2007.07.034
ER  - 



TY  - CPAPER
T1  - Cbl-dependent Regulation of LAT-nucleated Signaling Complexes
T2  - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007)
AN  - 39582675; 4738737
JF  - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007)
AU  - Balagopalan, L
AU  - Barr, V A
AU  - Sommers, C L
AU  - Barda-Saad, M
AU  - Goyal, A
AU  - Isakowitz, M E
AU  - Samelson, L E
Y1  - 2007/12/01/
PY  - 2007
DA  - 2007 Dec 01
KW  - Signal transduction
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39582675?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cbl-dependent+Regulation+of+LAT-nucleated+Signaling+Complexes&rft.au=Balagopalan%2C+L%3BBarr%2C+V+A%3BSommers%2C+C+L%3BBarda-Saad%2C+M%3BGoyal%2C+A%3BIsakowitz%2C+M+E%3BSamelson%2C+L+E&rft.aulast=Balagopalan&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.ascb.org/meetings/index.cfm?ID=103
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - RPRT
T1  - Table of contents
AN  - 236493173
JF  - Technical Report Series. National Toxicology Program
AU  - Anonymous
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 4
CY  - Research Triangle Park
PB  - U.S. Public Health Service, National Toxicology Program
KW  - Environmental Studies
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LA  - English
DB  - ProQuest Central; ProQuest Environmental Science Collection
N1  - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2007
N1  - Last updated - 2015-03-22
ER  - 



TY  - RPRT
T1  - TOXICOLOGY AND CARCINOGENESIS STUDY OF GENISTEIN (CAS NO. 446-72-0) IN SPRAGUE-DAWLEY RATS (FEED STUDY)
AN  - 236471144; 18685716
AB  - Genistein is an isoflavone that occurs in soy products including soy-based infant formulas. Genistein is one of a class of chemicals known as "environmental estrogens" which can affect the homione activities and possibly reproductive function of wildlife and humans through exposure. The NTP conducted a series of studies on three such chemicals to detect if exposure to such chemicals over the course of multiple generations could have any cumulative effect on animals' reproductive systems or development of cancers. This report describes the results of a set of studies in which rats were exposed to genistein for part or all of the study period and examined at the end of two years. The study consisted of three separate study components; in each, animals were exposed to genistein from the time of conception and through weaning through theft mothers, who were given genistein in their feed. In one study, we gave feed containing 5, 100, or 500 parts per million (ppm) of genistein to groups of 50 male and female rats from conception through two years. In the second study, groups of 50 male and female rats were given the same feed concentrations up to 20 weeks following birth, followed by untreated feed for the remainder of the two years. In the third study, groups of 50 male and female rats were exposed from conception through weaning, and then given untreated feed for the duration of the study. Control animals received the same feed with no chemical added. At the end of the study, tissues from more than 40 sites were examined for every animal. In none of the three studies were there any increased rates of cancer in male rats. In female rats exposed to genistein from conception and throughout two years, the rates of adenoma or adenocarcinoma of the mammary gland and pituitary gland adenoma or carcinoma were increased. In female rats exposed to genistein for 20 weeks following birth, the rates of pituitary gland adenoma or carcinoma were slightly increased, and in female rats exposed to genistein just from conception through weaning, the rates of mammary gland adenoma or adenocarcinoma were slightly increased. We conclude that exposure to genistein for two years caused tumors of the mammary gland and pituitary gland in female rats. Exposure to genistein for shorter durations following birth was also possibly associated with increased rates of pituitary gland and mammary gland tumors.
JF  - Technical Report Series. National Toxicology Program
AU  - Anonymous
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 1
EP  - 240
CY  - Research Triangle Park
PB  - U.S. Public Health Service, National Toxicology Program
KW  - Environmental Studies
KW  - Phytoestrogens
KW  - Xenobiotics
KW  - Genistein
KW  - Toxicology
KW  - Carcinogens
KW  - Rodents
KW  - Chemicals
KW  - Pituitary gland
KW  - Pituitary Neoplasms -- chemically induced
KW  - Animals
KW  - Litter Size -- drug effects
KW  - Kidney -- pathology
KW  - Mammary Glands, Animal -- drug effects
KW  - Mammary Neoplasms, Animal -- pathology
KW  - Longevity -- drug effects
KW  - Kidney -- drug effects
KW  - Mammary Neoplasms, Animal -- chemically induced
KW  - Neoplasms, Experimental -- pathology
KW  - Estrous Cycle -- drug effects
KW  - Pregnancy
KW  - Rats
KW  - Prenatal Exposure Delayed Effects -- pathology
KW  - Rats, Sprague-Dawley
KW  - Pituitary Neoplasms -- pathology
KW  - Prenatal Exposure Delayed Effects -- chemically induced
KW  - Mammary Glands, Animal -- pathology
KW  - Body Weight -- drug effects
KW  - Female
KW  - Male
KW  - Phytoestrogens -- toxicity
KW  - Reproduction -- drug effects
KW  - Neoplasms, Experimental -- etiology
KW  - Toxicity Tests, Chronic
KW  - Genistein -- toxicity
KW  - Xenobiotics -- toxicity
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LA  - English
DB  - ProQuest Central; ProQuest Environmental Science Collection
N1  - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2007
N1  - Document feature - Tables; Graphs; References
N1  - Last updated - 2015-03-22
ER  - 



TY  - RPRT
T1  - FOREWORD
AN  - 236458206
AB  - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public.
JF  - Technical Report Series. National Toxicology Program
AU  - Anonymous
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 1
CY  - Research Triangle Park
PB  - U.S. Public Health Service, National Toxicology Program
KW  - Environmental Studies
KW  - Environmental health
KW  - Public health
KW  - Laboratory animals
KW  - Human exposure
KW  - Health services
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LA  - English
DB  - ProQuest Central; ProQuest Environmental Science Collection
N1  - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2007
N1  - Last updated - 2015-03-22
ER  - 



TY  - JOUR
T1  - A Laboratory Preparation of Aspartame Analogs Using Simultaneous Multiple Parallel Synthesis Methodology
AN  - 211952861
AB  - Solid-phase peptide synthesis (SPPS), pioneered by Merrifield in 1963, is an essential method for synthesizing peptides in the laboratory. In SPPS the "solid state" is a polymeric resin bead with a functional group to which amino acids are chemically attached one-by-one until the desired peptide sequence is achieved. Here, Qvit et al detail how the synthesis and characterization of three dipeptide analogs of aspartame is demonstrated using the tea bag methodology, and how solid-phase methodology using the Fmoc chemistry is employed in this experiment.
JF  - Journal of Chemical Education
AU  - Qvit, Nir
AU  - Barda, Yaniv
AU  - Gilon, Chaim
AU  - Shalev, Deborah E
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 1988
CY  - Easton
PB  - American Chemical Society
VL  - 84
IS  - 12
SN  - 00219584
KW  - Chemistry
KW  - Peptides
KW  - Amino acids
KW  - Chemical synthesis
KW  - Biochemistry
KW  - Artificial sweeteners
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LA  - English
DB  - ProQuest Central
N1  - Copyright - Copyright American Chemical Society Dec 2007
N1  - Document feature - References; Diagrams
N1  - Last updated - 2014-05-18
N1  - CODEN - JCEDA8
ER  - 



TY  - JOUR
T1  - Litterfall production in the Brazilian mid-western Amazonia-Cerrado transition forest
TT  - Producao de serrapilheira no Cerrado e Floresta de Transicao Amazonia-Cerrado do Centro-Oeste Brasileiro
AN  - 20973035; 8542956
AB  - (Litterfall production in the Brazilian mid-western Amazonia-Cerrado transition forest). The objective of the present work was to verify the variation of litterfall production of different biomass: a cerrado ("savanna") with vegetation types Cerrado sensu stricto ("orchard-like vegetation") and Cerradao ("woodland-like vegetation") and Amazonia-Cerrado transition forest in a tropical climate. To determine the litterfall production, we used nylon screen traps. Micrometereologic data was collected in both areas of study. The litterfall in two biomass revealed diemselves as seasonal, with the highest productions occurring during the dry season and the lowest during the wet. The biggest litterfall occurred in the Transition Forest, followed by the Cerrado biome. Leaf fraction was more representative than twigs, flowers, fruits in both areas studied.
JF  - Acta Amazonica
AU  - da Silva, CJ
AU  - Sanches, L
AU  - Bleich, ME
AU  - Lobo, FDA
AU  - Nogueira, JDS
AD  - Universidade do Estado de Mato Grosso, Campus de Alta Floresta, Departamento de Engenharia Florestal, cjsnx@yahoo.com.br
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 543
EP  - 548
VL  - 37
IS  - 4
SN  - 0044-5967, 0044-5967
KW  - Ecology Abstracts
KW  - Fruits
KW  - Flowers
KW  - Data processing
KW  - Climate
KW  - Traps
KW  - Vegetation
KW  - Forests
KW  - Biomass
KW  - D 04040:Ecosystem and Ecology Studies
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LA  - Portuguese
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-10-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Forests; Vegetation; Biomass; Traps; Data processing; Fruits; Climate; Flowers
ER  - 



TY  - JOUR
T1  - Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma
AN  - 20724372; 7933525
AB  - A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma.
JF  - Carcinogenesis
AU  - Brenner, A V
AU  - Butler, MA
AU  - Wang, S S
AU  - Ruder, A M
AU  - Rothman, N
AU  - Schulte, P A
AU  - Chanock, S J
AU  - Fine, HA
AU  - Linet
AU  - Inskip, P D
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. Division of Applied Research and Technology, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Education and Information Division, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Core Genotyping Facility, Advanced Technology Corporation, National Cancer Institute, NIH, DHHS, Gaithersburg, MD, 20892-4605, USA. Neurooncology Branch, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD, 20892-8200, USA
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 2543
EP  - 2547
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 28
IS  - 12
SN  - 0143-3334, 0143-3334
KW  - Health & Safety Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts
KW  - Interleukin 6
KW  - Historical account
KW  - Interleukin 4
KW  - Etiology
KW  - Occupational safety
KW  - Autoimmune diseases
KW  - autoimmune diseases
KW  - Population studies
KW  - Allergies
KW  - Cancer
KW  - Brain tumors
KW  - glioma
KW  - Hypersensitivity
KW  - Single-nucleotide polymorphism
KW  - Carcinogenesis
KW  - Cytokines
KW  - Glioma
KW  - G 07720:Immunogenetics
KW  - F 06925:Hypersensitivity
KW  - H 1000:Occupational Safety and Health
KW  - N 14845:Miscellaneous
KW  - N3 11024:Neuroimmunology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Interleukin 6; Brain tumors; Etiology; Hypersensitivity; Interleukin 4; Single-nucleotide polymorphism; Autoimmune diseases; Carcinogenesis; Population studies; Cytokines; Glioma; Historical account; glioma; Occupational safety; autoimmune diseases; Allergies; Cancer
ER  - 



TY  - JOUR
T1  - beta -Ionone reactions with ozone and OH radical: Rate constants and gas-phase products
AN  - 20692308; 8182568
AB  - The bimolecular rate constants, k sub(O) sub(H) sub(?) sub(+) sub( beta ) sub(-) sub(i) sub(o) sub(n) sub(o) sub(n) sub(e) (118+/-30)x10 super(-) super(1) super(2)cm super(3)molecule super(-) super(1)s super(-) super(1) and k sub(O) sub(3) sub(+) sub( beta ) sub( approximately equal to ) sub(i) sub(o) sub(n) sub(o) sub(n) sub(e), (0.19+ /-0.05)x10 super(-) super(1) super(6)cm super(3)molecule super(-) super(1)s super(-) super(1), were measured using the relative rate technique for the reaction of the hydroxyl radical (OH) and ozone (O sub(3)) with 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one ( beta -ionone) at 297+/-3K and 1atm total pressure. To more clearly define part of beta -ionone's indoor environment degradation mechanism, the products of the beta -ionone+OH? and beta -ionone+O sub(3) reactions were also investigated. The identified beta -ionone+OH? reaction products were: glyoxal (ethanedial, HC(=O)C(=O)H), and methylglyoxal (2-oxopropanal, CH sub(3)C(=O)C(=O)H) and the identified beta -ionone+O sub(3) reaction product was 2-oxopropanal. The derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) were used to propose 2,6,6-trimethylcyclohex-1-ene-1-carbaldehyde as the other major beta -ionone+OH? and beta -ionone+O sub(3) reaction product. The elucidation of this other reaction product was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible beta -ionone+OH? and beta -ionone+O sub(3) reaction mechanisms based on previously published volatile organic compound+OH? and volatile organic compound+O sub(3) gas-phase reaction mechanisms. The additional gas-phase products observed from the beta -ionone+OH? reaction are proposed to be the result of cyclization through a radical intermediate.
JF  - Atmospheric Environment
AU  - Forester, C D
AU  - Ham, JE
AU  - Wells, J R
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, ozw0@cdc.gov
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 8758
EP  - 8771
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 41
IS  - 38
SN  - 1352-2310, 1352-2310
KW  - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts
KW  - Ozone measurements
KW  - Mass spectrometry
KW  - Hydroxyl radicals
KW  - Hydroxyl photochemistry
KW  - Indoor environments
KW  - Ozone
KW  - M2 551.510.42:Air Pollution (551.510.42)
KW  - P 0000:AIR POLLUTION
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Ozone measurements; Mass spectrometry; Hydroxyl photochemistry; Ozone; Indoor environments; Hydroxyl radicals
DO  - http://dx.doi.org/10.1016/j.atmosenv.2007.07.047
ER  - 



TY  - JOUR
T1  - Overview of monoclonal B-cell lymphocytosis
AN  - 20588748; 7978368
AB  - Monoclonal B-cell lymphocytosis (MBL) has been the subject of more intensive investigation for the last 10 years. The increased presence of MBL in unaffected, first-degree relatives with familial chronic lymphocytic leukaemia (CLL) suggest that it is surrogate marker for early disease. In normal population studies, MBL is found to be increased in ageing subjects. Consensus criteria for the diagnosis of MBL have been proposed. The differential diagnosis has been further clarified and the prevalence of MBL is most prominent in the elderly. The aetiology of MBL is unknown but probably involves immune mechanism of senescence or altered response. Environmental health studies suggest that exposure to certain toxins may lead to MBL but further work is needed. MBL is a precursor to CLL but may also regress, remain stable or progress to clinical CLL.
JF  - British Journal of Haematology
AU  - Marti, Gerald
AU  - Abbasi, Fatima
AU  - Raveche, Elizabeth
AU  - Rawstron, Andy C
AU  - Ghia, Paolo
AU  - Aurran, Therese
AU  - Caporaso, Neil
AU  - Shim, Youn K
AU  - Vogt, Robert F
AD  - Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), NIH, Bethesda, MD, gemarti@helix.nih.gov
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 701
EP  - 708
PB  - Blackwell Publishing Ltd., 9600 Garsington Road
VL  - 139
IS  - 5
SN  - 0007-1048, 0007-1048
KW  - Health & Safety Science Abstracts; Immunology Abstracts
KW  - chronic lymphocytic leukaemia
KW  - monoclonal B-cell lymphocytosis
KW  - Lymphocytes B
KW  - Aging
KW  - Environmental health
KW  - Population studies
KW  - Toxins
KW  - population studies
KW  - Leukemia
KW  - Lymphocytosis
KW  - Differential diagnosis
KW  - Reviews
KW  - senescence
KW  - Geriatrics
KW  - Senescence
KW  - elderly
KW  - Chronic lymphatic leukemia
KW  - F 06915:Cancer Immunology
KW  - H 12000:Epidemiology and Public Health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Differential diagnosis; Lymphocytosis; Lymphocytes B; Reviews; Aging; Geriatrics; Population studies; Senescence; Chronic lymphatic leukemia; Toxins; population studies; Leukemia; senescence; Environmental health; elderly
DO  - http://dx.doi.org/10.1111/j.1365-2141.2007.06865.x
ER  - 



TY  - JOUR
T1  - Gastroenteritis Outbreak Caused by Waterborne Norovirus at a New Zealand Ski Resort
AN  - 20552086; 7932127
AB  - In July 2006, public health services investigated an outbreak of acute gastroenteritis among staff and visitors of a popular ski resort in southern New Zealand. The source of the outbreak was a drinking water supply contaminated by human sewage. The virological component of the investigation played a major role in confirming the source of the outbreak. Drinking water, source stream water, and 31 fecal specimens from gastroenteritis outbreak cases were analyzed for the presence of norovirus (NoV). Water samples were concentrated by ultrafiltration, and real-time reverse transcription-PCR (RT-PCR) was used for rapid detection of NoV from both water and fecal samples. The implicated NoV strain was further characterized by DNA sequencing. NoV genogroup GI/5 was identified in water samples and linked case fecal specimens, providing clear evidence of the predominant pathogen and route of exposure. A retrospective cohort study demonstrated that staff who consumed drinking water from the resort supply were twice as likely to have gastroenteritis than those who did not. This is the first time that an outbreak of gastroenteritis in New Zealand has been conclusively linked to NoV detected in a community water supply. To our knowledge, this is the first report of the use of ultrafiltration combined with quantitative real-time RT-PCR and DNA sequencing for investigation of a waterborne NoV outbreak.
JF  - Applied and Environmental Microbiology
AU  - Hewitt, Joanne
AU  - Bell, Derek
AU  - Simmons, Greg C
AU  - Rivera-Aban, Malet
AU  - Wolf, Sandro
AU  - Greening, Gail E
AD  - Communicable Disease Group, Institute of Environmental Science & Research Ltd., Kenepuru Science Centre, P.O. Box 50-348, Porirua, New Zealand. Public Health South, P.O. Box 2180, Queenstown, New Zealand. Auckland Regional Public Health Service, Private Bag 92605, Auckland, New Zealand
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 7853
EP  - 7857
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 73
IS  - 24
SN  - 0099-2240, 0099-2240
KW  - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - Ultrafiltration
KW  - Norovirus
KW  - Pathogens
KW  - Streams
KW  - Water supplies
KW  - Ski protein
KW  - Public health
KW  - DNA sequencing
KW  - Sewage
KW  - Polymerase chain reaction
KW  - Gastroenteritis
KW  - Drinking water
KW  - V 22490:Miscellaneous
KW  - A 01450:Environmental Pollution & Waste Treatment
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-02-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Ultrafiltration; DNA sequencing; Sewage; Polymerase chain reaction; Pathogens; Drinking water; Gastroenteritis; Water supplies; Streams; Public health; Ski protein; Norovirus
ER  - 



TY  - JOUR
T1  - Anaerobic Metabolism of 1-Amino-2-Naphthol-Based Azo Dyes (Sudan Dyes) by Human Intestinal Microflora
AN  - 20550202; 7928276
AB  - The rates of metabolism of Sudan I and II and Para Red by human intestinal microflora were high compared to those of Sudan III and IV under anaerobic conditions. Metabolites of the dyes were identified as aniline, 2,4-dimethylaniline, o-toluidine, and 4-nitroaniline through high-performance liquid chromatography and liquid chromatography electrospray ionization tandem mass spectrometry analyses. These data indicate that human intestinal bacteria are able to reduce Sudan dyes to form potentially carcinogenic aromatic amines.
JF  - Applied and Environmental Microbiology
AU  - Xu, Haiyan
AU  - Heinze, Thomas M
AU  - Chen, Siwei
AU  - Cerniglia, Carl E
AU  - Chen, Huizhong
AD  - Division of Microbiology. Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079-9502
Y1  - 2007/12/01/
PY  - 2007
DA  - 2007 Dec 01
SP  - 7759
EP  - 7762
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 73
IS  - 23
SN  - 0099-2240, 0099-2240
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - High-performance liquid chromatography
KW  - Data processing
KW  - Azo dyes
KW  - o-toluidine
KW  - Metabolites
KW  - Anaerobic conditions
KW  - Mass spectroscopy
KW  - Intestinal microflora
KW  - amines
KW  - Dyes
KW  - Liquid chromatography
KW  - Intestine
KW  - Aromatics
KW  - Aniline
KW  - A 01450:Environmental Pollution & Waste Treatment
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-02-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Data processing; Azo dyes; o-toluidine; Metabolites; Anaerobic conditions; Mass spectroscopy; Intestinal microflora; amines; Dyes; Liquid chromatography; Intestine; Aromatics; Aniline
ER  - 



TY  - JOUR
T1  - Serious Psychological Distress Among Parenting and Nonparenting Adults
AN  - 20522255; 7928565
AB  - OBJECTIVES: We compared the prevalence of serious psychological distress among parenting adults with the prevalence among nonparenting adults and the sociodemographic correlates of serious psychological distress between these 2 populations. METHODS: We drew data from 14240 parenting adults and 19224 nonparenting adults who responded to the 2002 National Survey on Drug Use and Health. We used logistic regression procedures in our analysis. RESULTS: An estimated 8.9% of parenting adults had serious psychological distress in the prior year compared with 12.0% of nonparenting adults of similar age. In both groups, the adjusted odds of having serious psychological distress were higher among adults who were women, younger (between the ages of 18 and 44 years), low income, or receiving Medicaid. We found some differences in the correlates of serious psychological distress between parenting adults and nonparenting adults. The odds of having serious psychological distress were lower among parenting adults after we controlled for demographic characteristics. CONCLUSIONS: Serious psychological distress is fairly prevalent among parenting adults, and high-risk sociodemographic groups of parenting adults should be targeted to ensure access to coordination of services.
JF  - American Journal of Public Health
AU  - Herman-Stahl, Mindy
AU  - Ashley, Olivia Silber
AU  - Penne, Michael A
AU  - Bauman, Karl E
AU  - Weitzenkamp, David
AU  - Aldridge, Molly
AU  - Gfroerer, Joseph C
AD  - Mindy Herman-Stahl, Olivia Silber Ashley, Michael A. Penne, Karl E. Bauman, and David Weitzenkamp are with RTI International, Research Triangle Park, NC. At the time of the study, Molly Aldridge was with RTI International, Research Triangle Park, NC. Joseph C. Gfroerer is with the Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, Md
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 2222
EP  - 2229
PB  - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA
VL  - 97
IS  - 12
SN  - 0090-0036, 0090-0036
KW  - Sustainability Science Abstracts
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2011-12-13
ER  - 



TY  - JOUR
T1  - Association of Smoking Cessation With Financial Stress and Material Well-Being: Results From a Prospective Study of a Population-Based National Survey
AN  - 20521906; 7928573
AB  - OBJECTIVES: We used 4 waves of prospective data to examine the association of smoking cessation with financial stress and material well-being. METHODS: Data (n = 5699 at baseline) came from 4 consecutive waves (2001-2005) of the Household Income and Labour Dynamics in Australia survey. We used mixed models to examine the participant-specific association of smoking cessation with financial stress and material well-being. RESULTS: On average, a smoker who quits is expected to have a 25% reduction (P<.001; odds ratio [OR]=0.75; 95% confidence interaval [CI]=0.69, 0.81) in the odds of financial stress. Similarly, the data provided strong evidence (P<.001) that a smoker who quits is likely to experience an enhanced level of material well-being. CONCLUSIONS: Our findings indicate that interventions to encourage smoking cessation are likely to improve standards of living and reduce deprivation. The findings provide grounds for encouraging the social services sector to incorporate smoking cessation efforts into their programs to enhance the material or financial conditions of disadvantaged groups. The findings also provide additional incentives for smokers to stop smoking and as such can be used in antismoking campaigns and by smoking cessation services.
JF  - American Journal of Public Health
AU  - Siahpush, Mohammad
AU  - Spittal, Matt
AU  - Singh, Gopal K
AD  - At the time of this study, Mohammad Siahpush and Matt Spittal were with the Centre for Behavioural Research in Cancer, Cancer Council Victoria, Victoria, Australia. Gopal K. Singh is with the Maternal and Child Health Bureau, Health Resources and Service Administration, Rockville, Md
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 2281
EP  - 2287
PB  - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA
VL  - 97
IS  - 12
SN  - 0090-0036, 0090-0036
KW  - Sustainability Science Abstracts
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2011-12-13
ER  - 



TY  - JOUR
T1  - The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance-linked ATP binding cassette drug transporter ABCG2
AN  - 20472676; 7936730
AB  - Vitamin K3 (menadione; 2-methyl-1,4-naphthoquinone) is a structural precursor of vitamins K1 and K2, which are essential for blood clotting. The naturally occurring structural analogue of this vitamin, plumbagin (5-hydroxy-menadione), is known to modulate cellular proliferation, apoptosis, carcinogenesis, and radioresistance. We here report that both vitamin K3 and plumbagin are substrates of the multidrug resistance-linked ATP binding cassette drug transporter, ABCG2. Vitamin K3 and plumbagin specifically inhibited the ABCG2-mediated efflux of mitoxantrone but did not have any effect on the ABCB1-mediated efflux of rhodamine 123. This inhibition of ABCG2 function was due to their interaction at the substrate-binding site(s). Vitamin K3 and plumbagin inhibited the binding of [ super(125)I]iodoarylazidoprazosin, a substrate of ABCG2, to this transporter in a concentration-dependent manner with IC sub(50) values of 7.3 and 22.6 mu mol/L, respectively, but had no effect on the binding of the photoaffinity analogue to ABCB1. Both compounds stimulated ABCG2-mediated ATP hydrolysis and also inhibited the mitoxantrone-stimulated ATPase activity of the ABCG2 transporter, but did not have any significant effect on the ATPase activity of ABCB1. In a cytotoxicity assay, ABCG2-expressing HEK cells were 2.8- and 2.3-fold resistant to plumbagin and vitamin K3, respectively, compared with the control cells, suggesting that they are substrates of this transporter. Collectively, these data show for the first time that vitamin K3 is a substrate of the ABCG2 transporter. Thus, ABCG2 may have a role in the regulation of vitamin K3 levels in the body. In addition, vitamin K3 and its structural derivative, plumbagin, could potentially be used to modulate ABCG2 function. [Mol Cancer Ther 2007; 6(12):3279-86]
JF  - Molecular Cancer Therapeutics
AU  - Shukla, Suneet
AU  - Wu, Chung-Pu
AU  - Nandigama, Krishnamachary
AU  - Ambudkar, Suresh V
AD  - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 3279
EP  - 3286
PB  - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/]
VL  - 6
IS  - 12
SN  - 1535-7163, 1535-7163
KW  - Biotechnology and Bioengineering Abstracts
KW  - Adenosinetriphosphatase
KW  - Apoptosis
KW  - ATP
KW  - Hydrolysis
KW  - Cancer
KW  - Blood coagulation
KW  - Stem cells
KW  - Cytotoxicity
KW  - Vitamins
KW  - Carcinogenesis
KW  - Menadione
KW  - Hemopoiesis
KW  - Plumbagin
KW  - Radioresistance
KW  - rhodamine
KW  - mitoxantrone
KW  - Drugs
KW  - W 30915:Pharmaceuticals & Vaccines
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-02-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Apoptosis; Adenosinetriphosphatase; ATP; Hydrolysis; Cancer; Cytotoxicity; Stem cells; Blood coagulation; Vitamins; Carcinogenesis; Menadione; Plumbagin; Hemopoiesis; Radioresistance; Drugs; mitoxantrone; rhodamine
ER  - 



TY  - JOUR
T1  - Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models
AN  - 20427212; 7938622
AB  - This report presents a comparison of the predictive performance of MC4PC and MDL-QSAR software as well as a method for combining the predictions from both programs to increase overall accuracy. The conclusions are based on 10x10% leave-many-out internal cross-validation studies using 1540 training set compounds with 2-year rodent carcinogenicity findings. The models were generated using the same weight of evidence scoring method previously developed [Matthews, E.J., Contrera, J.F., 1998. A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software. Regul. Toxicol. Pharmacol. 28, 242-264.]. Although MC4PC and MDL-QSAR use different algorithms, their overall predictive performance was remarkably similar. Respectively, the sensitivity of MC4PC and MDL-QSAR was 61 and 63%, specificity was 71 and 75%, and concordance was 66 and 69%. Coverage for both programs was over 95% and receiver operator characteristic (ROC) intercept statistic values were above 2.00. The software programs had complimentary coverage with none of the 1540 compounds being uncovered by both MC4PC and MDL-QSAR. Merging MC4PC and MDL-QSAR predictions improved the overall predictive performance. Consensus sensitivity increased to 67%, specificity to 84%, concordance to 76%, and ROC to 4.31. Consensus rules can be tuned to reflect the priorities of the user, so that greater emphasis may be placed on predictions with high sensitivity/low false negative rates or high specificity/low false positive rates. Sensitivity was optimized to 75% by reclassifying all compounds predicted to be positive in MC4PC or MDL-QSAR as positive, and specificity was optimized to 89% by reclassifying all compounds predicted negative in MC4PC or MDL-QSAR as negative.
JF  - Regulatory Toxicology and Pharmacology
AU  - Contrera, J F
AU  - Kruhlak, N L
AU  - Matthews, E J
AU  - Benz, R D
AD  - Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff, Mail Drop 1603, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA, Joseph.Contrera@fda.hhs.gov
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 172
EP  - 182
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 49
IS  - 3
SN  - 0273-2300, 0273-2300
KW  - Toxicology Abstracts
KW  - Computer programs
KW  - software
KW  - Carcinogenicity
KW  - Algorithms
KW  - Pharmaceuticals
KW  - X 24310:Pharmaceuticals
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Comparison+of+MC4PC+and+MDL-QSAR+rodent+carcinogenicity+predictions+and+the+enhancement+of+predictive+performance+by+combining+QSAR+models&rft.au=Contrera%2C+J+F%3BKruhlak%2C+N+L%3BMatthews%2C+E+J%3BBenz%2C+R+D&rft.aulast=Contrera&rft.aufirst=J&rft.date=2007-12-01&rft.volume=49&rft.issue=3&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2007.07.001
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Computer programs; software; Carcinogenicity; Algorithms; Pharmaceuticals
DO  - http://dx.doi.org/10.1016/j.yrtph.2007.07.001
ER  - 



TY  - JOUR
T1  - Assessment of Child and Adolescent Overweight and Obesity
AN  - 20375804; 7745308
AB  - Accurate appropriate assessment of overweight and obesity in children and adolescents is a critical aspect of contemporary medical care. However, physicians and other health care professionals may find this a somewhat thorny field to enter. The BMI has become the standard as a reliable indicator of overweight and obesity. The BMI is incomplete, however, without consideration of the complex behavioral factors that influence obesity.Because of limited time and resources, clinicians need to have quick, evidence-based interventions that can help patients and their families recognize the importance of reducing overweight and obesity and take action. In an era of fast food, computers, and DVDs, it is not easy to persuade patients to modify their diets and to become more physically active. Because research concerning effective assessment of childhood obesity contains many gaps, this report is intended to provide a comprehensive approach to assessment and to present the evidence available to support key aspects of assessment. The discussion and recommendations are based on >300 studies published since 1995, which examined an array of assessment tools. With this information, clinicians should find themselves better equipped to face the challenges of assessing childhood overweight and obesity accurately.
JF  - Pediatrics
AU  - Krebs, Nancy F
AU  - Himes, John H
AU  - Jacobson, Dawn
AU  - Nicklas, Theresa A
AU  - Guilday, Patricia
AU  - Styne, Dennis
AD  - Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota. Office of Disease Prevention and Health Promotion, Department of Health and Human Services, Rockville, Maryland. Department of Pediatrics, Baylor College of Medicine, Houston, Texas. PS duPont Elementary School, Wilmington, Delaware. Department of Pediatrics, University of California, Davis, Sacramento, California
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - S193
EP  - S228
PB  - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org]
VL  - 120
SN  - 0031-4005, 0031-4005
KW  - Physical Education Index
KW  - Obesity
KW  - Health (care)
KW  - Diet (effects)
KW  - Pediatrics
KW  - Adolescence
KW  - Body mass
KW  - Computers
KW  - Patients
KW  - Children
KW  - Evaluation
KW  - Family
KW  - Physicians
KW  - PE 030:Exercise, Health & Physical Fitness
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Assessment+of+Child+and+Adolescent+Overweight+and+Obesity&rft.au=Krebs%2C+Nancy+F%3BHimes%2C+John+H%3BJacobson%2C+Dawn%3BNicklas%2C+Theresa+A%3BGuilday%2C+Patricia%3BStyne%2C+Dennis&rft.aulast=Krebs&rft.aufirst=Nancy&rft.date=2007-12-01&rft.volume=120&rft.issue=&rft.spage=S193&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/
LA  - English
DB  - Physical Education Index
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Evaluation; Obesity; Diet (effects); Health (care); Pediatrics; Computers; Body mass; Adolescence; Family; Physicians; Patients; Children
ER  - 



TY  - JOUR
T1  - AUC/MIC: a PK/PD index for antibiotics with a time dimension or simply a dimensionless scoring factor?
AN  - 20373139; 7741463
AB  - A previous article on standardization of pharmacokinetic/pharmacodynamic terminology for anti-infective drugs recommended deletion of the units of the AUC/MIC ratio (actually h). We express here the difficulties presented by this proposal and we propose expressing AUC/MIC as a scaling factor corresponding to the current index divided now by 24 h. This is the scaling factor without units by which the targeted MIC should be multiplied to estimate the average in vivo plasma concentration to be achieved. Associated with this proposal, we address the specific issue of veterinary drug products for which steady conditions are seldom achieved. To accommodate the need for dose prediction during these novel therapeutic situations, we propose a general approach that is based on the targeted time interval over which some desired average concentration should be maintained.
JF  - Journal of Antimicrobial Chemotherapy
AU  - Toutain, Pierre-Louis
AU  - Bousquet-Melou, Alain
AU  - Martinez, Marilyn
AD  - UMR181 Physiopathologie et Toxicologie Experimentales INRA, ENVT, 23 Chemin des Capelles, 31076 Toulouse cedex 03, France. FDA, Center for Veterinary Medicine, Rockville, MD, USA
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 1185
EP  - 1188
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 60
IS  - 6
SN  - 0305-7453, 0305-7453
KW  - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - Standardization
KW  - Antibiotics
KW  - Minimum inhibitory concentration
KW  - Drugs
KW  - Pharmacokinetics
KW  - Pharmacodynamics
KW  - A 01350:Microbial Resistance
KW  - J 02340:Antibiotics & Antimicrobials
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373139?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=AUC%2FMIC%3A+a+PK%2FPD+index+for+antibiotics+with+a+time+dimension+or+simply+a+dimensionless+scoring+factor%3F&rft.au=Toutain%2C+Pierre-Louis%3BBousquet-Melou%2C+Alain%3BMartinez%2C+Marilyn&rft.aulast=Toutain&rft.aufirst=Pierre-Louis&rft.date=2007-12-01&rft.volume=60&rft.issue=6&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Standardization; Antibiotics; Drugs; Minimum inhibitory concentration; Pharmacodynamics; Pharmacokinetics
ER  - 



TY  - JOUR
T1  - Differential Requirements by CD4 super(+) and CD8 super(+) T Cells for Soluble and Membrane TNF in Control of Francisella tularensis Live Vaccine Strain Intramacrophage Growth
AN  - 20324339; 7743272
AB  - During primary infection with intracellular bacteria, the membrane-associated form of TNF provides some TNF functions, but the relative contributions during memory responses are not well-characterized. In this study, we determined the role of T cell-derived secreted and membrane-bound TNF (memTNF) during adaptive immunity to Francisella tularensis live vaccine strain (LVS). Although transgenic mice expressing only the memTNF were more susceptible to primary LVS infection than wild-type (WT) mice, LVS-immune WT and memTNF mice both survived maximal lethal secondary Francisella challenge. Generation of CD44 super(high) memory T cells and clearance of bacteria were similar, although more IFN- gamma and IL-12(p40) were produced by memTNF mice. To examine T cell function, we used an in vitro tissue coculture system that measures control of LVS intramacrophage growth by LVS-immune WT and memTNF-T cells. LVS-immune CD4 super(+) and CD8 super(+) T cells isolated from WT and memTNF mice exhibited comparable control of LVS growth in either normal or TNF- alpha knockout macrophages. Although the magnitude of CD4 super(+) T cell-induced macrophage NO production clearly depended on TNF, control of LVS growth by both CD4 super(+) and CD8 super(+) T cells did not correlate with levels of nitrite. Importantly, intramacrophage LVS growth control by CD8 super(+) T cells, but not CD4 super(+) T cells, was almost entirely dependent on T cell-expressed TNF, and required stimulation through macrophage TNFRs. Collectively, these data demonstrate that T cell-expressed memTNF is necessary and sufficient for memory T cell responses to this intracellular pathogen, and is particularly important for intramacrophage control of bacterial growth by CD8 super(+) T cells.
JF  - Journal of Immunology
AU  - Cowley, Siobhan C
AU  - Sedgwick, Jonathon D
AU  - Elkins, Karen L
AD  - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, U.S. Food and Drug Administration, Rockville, MD 20852. Eli Lilly and Company, Indianapolis, IN 46285
Y1  - 2007/12/01/
PY  - 2007
DA  - 2007 Dec 01
SP  - 7709
EP  - 7719
PB  - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/]
VL  - 179
IS  - 11
SN  - 0022-1767, 0022-1767
KW  - Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW  - Macrophages
KW  - gamma -Interferon
KW  - Memory cells
KW  - Immunological memory
KW  - Francisella tularensis
KW  - Pathogens
KW  - CD8 antigen
KW  - Transgenic mice
KW  - Infection
KW  - Tumor necrosis factor receptors
KW  - CD4 antigen
KW  - Lymphocytes T
KW  - Nitric oxide
KW  - Tumor necrosis factor- alpha
KW  - Vaccines
KW  - Nitrite
KW  - F 06905:Vaccines
KW  - J 02350:Immunology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Macrophages; gamma -Interferon; Immunological memory; Memory cells; CD8 antigen; Pathogens; Infection; Transgenic mice; Tumor necrosis factor receptors; CD4 antigen; Lymphocytes T; Nitric oxide; Vaccines; Tumor necrosis factor- alpha; Nitrite; Francisella tularensis
ER  - 



TY  - JOUR
T1  - ANTIMICROBIAL SUSCEPTIBILITY AND DISTRIBUTION OF ANTIMICROBIAL-RESISTANCE GENES AMONG ENTEROCOCCUS AND COAGULASE-NEGATIVE STAPHYLOCOCCUS ISOLATES RECOVERED FROM POULTRY LITTER
AN  - 20216882; 8698549
JF  - Avian Diseases Digest
AU  - Simjee, Shabbir
AU  - McDermott, Patrick F
AU  - White, David G
AU  - Hofacre, Charles
AU  - Berghaus, Roy D
AU  - Carter, Peggy J
AU  - Stewart, Leigh
AU  - LIU, TONGRUI
AU  - Maier, Marie
AU  - Maurer, John J
AD  - Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - e23
PB  - American Association of Avian Pathologists
VL  - 2
IS  - 4
SN  - 1933-5334, 1933-5334
KW  - Microbiology Abstracts B: Bacteriology; Genetics Abstracts
KW  - Litter
KW  - Poultry
KW  - Enterococcus
KW  - Staphylococcus
KW  - Antimicrobial agents
KW  - J 02410:Animal Diseases
KW  - G 07770:Bacteria
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Avian+Diseases+Digest&rft.atitle=ANTIMICROBIAL+SUSCEPTIBILITY+AND+DISTRIBUTION+OF+ANTIMICROBIAL-RESISTANCE+GENES+AMONG+ENTEROCOCCUS+AND+COAGULASE-NEGATIVE+STAPHYLOCOCCUS+ISOLATES+RECOVERED+FROM+POULTRY+LITTER&rft.au=Simjee%2C+Shabbir%3BMcDermott%2C+Patrick+F%3BWhite%2C+David+G%3BHofacre%2C+Charles%3BBerghaus%2C+Roy+D%3BCarter%2C+Peggy+J%3BStewart%2C+Leigh%3BLIU%2C+TONGRUI%3BMaier%2C+Marie%3BMaurer%2C+John+J&rft.aulast=Simjee&rft.aufirst=Shabbir&rft.date=2007-12-01&rft.volume=2&rft.issue=4&rft.spage=e23&rft.isbn=&rft.btitle=&rft.title=Avian+Diseases+Digest&rft.issn=19335334&rft_id=info:doi/10.1637%2F1933-5334%282007%2922.0.CO%3B2
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-07-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Staphylococcus; Enterococcus; Poultry; Antimicrobial agents; Litter
DO  - http://dx.doi.org/10.1637/1933-5334(2007)2[e23:ASADOA]2.0.CO;2
ER  - 



TY  - JOUR
T1  - Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes III. An Efficient Method of Monitoring Chromosomal Damage in the Beagle Dog
AN  - 20046077; 7746661
AB  - Erythrocyte-based micronucleus tests have traditionally analyzed bone marrow because splenic filtration in most species removes micronucleated cells from peripheral blood. We have evaluated a flow cytometric method for monitoring micronucleated reticulocyte frequencies (%MN-RET) in the peripheral blood of beagle dogs treated with cyclophosphamide (CP) and have found that analysis of micronucleated reticulocytes (MN-RETs) in peripheral blood is a suitable surrogate for bone marrow analysis. The three-color flow cytometric method uses anti-CD71 labeling to identify reticulocytes and Plasmodium berghei-containing erythrocytes as a calibration standard. The spontaneous %MN-RET determined by flow cytometry was 0.31 plus or minus 0.09% (n = 22) for peripheral blood, compared with 0.38 plus or minus 0.13% (SD, n = 12) for bone marrow, and 0.27 plus or minus 0.08% (n = 12) for peripheral blood by microscopic scoring with acridine orange staining. The kinetics of appearance and disappearance of MN-RETs in blood were determined by collecting daily samples after iv treatment with CP. The maximum frequency occurred similar to 48 h after dosing. Frequencies of MN-RETs in peripheral blood at steady state following daily CP treatment were 55-68% of corresponding bone marrow values assessed by microscopy and 55-112% as assessed by flow cytometry. This difference is presumably due to splenic removal, which appears slightly less stringent than that previously reported for CP-treated Sprague-Dawley rats. Responses in bone marrow and peripheral blood were highly correlated and similar to or greater than those reported in mice and rats at equitoxic doses.
JF  - Toxicological Sciences
AU  - Harper, Susan B
AU  - Dertinger, Stephen D
AU  - Bishop, Michelle E
AU  - Lynch, Anthony M
AU  - Lorenzo, Maria
AU  - Saylor, Michelle
AU  - MacGregor, James T
AD  - Department of Veterans Affairs, Washington, DC 20422. Litron Laboratories, Rochester, NY 14623. National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079. GlaxoSmithKline Research & Development, Herts, SG12 0DP, UK. U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Laurel, MD 20708. Toxicology Consulting Services, Arnold, MD 21012
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 406
EP  - 414
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 100
IS  - 2
SN  - 1096-6080, 1096-6080
KW  - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts
KW  - Acridine orange
KW  - Micronuclei
KW  - Erythrocytes
KW  - Bone marrow
KW  - Spleen
KW  - Peripheral blood
KW  - Cyclophosphamide
KW  - Flow cytometry
KW  - Plasmodium
KW  - Filtration
KW  - Kinetics
KW  - Microscopy
KW  - Reticulocytes
KW  - K 03410:Animal Diseases
KW  - G 07870:Mammals
KW  - X 24300:Methods
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20046077?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Flow+Cytometric+Analysis+of+Micronuclei+in+Peripheral+Blood+Reticulocytes+III.+An+Efficient+Method+of+Monitoring+Chromosomal+Damage+in+the+Beagle+Dog&rft.au=Harper%2C+Susan+B%3BDertinger%2C+Stephen+D%3BBishop%2C+Michelle+E%3BLynch%2C+Anthony+M%3BLorenzo%2C+Maria%3BSaylor%2C+Michelle%3BMacGregor%2C+James+T&rft.aulast=Harper&rft.aufirst=Susan&rft.date=2007-12-01&rft.volume=100&rft.issue=2&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Acridine orange; Flow cytometry; Filtration; Kinetics; Microscopy; Erythrocytes; Micronuclei; Bone marrow; Spleen; Peripheral blood; Cyclophosphamide; Reticulocytes; Plasmodium
ER  - 



TY  - JOUR
T1  - Variability of Total and Pathogenic Vibrio parahaemolyticus Densities in Northern Gulf of Mexico Water and Oysters
AN  - 19993264; 7928254
AB  - Vibrio parahaemolyticus is indigenous to coastal environments and a frequent cause of seafood-borne gastroenteritis in the United States, primarily due to raw-oyster consumption. Previous seasonal-cycle studies of V. parahaemolyticus have identified water temperature as the strongest environmental predictor. Salinity has also been identified, although it is evident that its effect on annual variation is not as pronounced. The effects of other environmental factors, both with respect to the seasonal cycle and intraseasonal variation, are uncertain. This study investigated intraseasonal variations of densities of total and pathogenic V. parahaemolyticus organisms in oysters and overlying waters during the summer of 2004 at two sites in the northern Gulf of Mexico. Regression analyses indicated significant associations (P < 0.001) between total V. parahaemolyticus densities and salinity, as well as turbidity in water and in oysters at the Mississippi site but not at the Alabama site. Pathogenic V. parahaemolyticus organisms in Mississippi oyster and water samples were detected in 56% (9 out of 16) and 78% (43 out of 55) of samples, respectively. In contrast, 44% (7 out of 16) of oyster samples and 30% (14 out of 47) of water samples from Alabama were positive. At both sites, there was greater sample-to-sample variability in pathogenic V. parahaemolyticus densities than in total V. parahaemolyticus densities. These data suggest that, although total V. parahaemolyticus densities may be very informative, there is greater uncertainty when total V. parahaemolyticus densities are used to predict the risk of infection by pathogenic V. parahaemolyticus than previously recognized.
JF  - Applied and Environmental Microbiology
AU  - Zimmerman, A M
AU  - DePaola, A
AU  - Bowers, J C
AU  - Krantz, JA
AU  - Nordstrom, J L
AU  - Johnson, C N
AU  - Grimes, D J
AD  - University of Southern Mississippi, Gulf Coast Research Laboratory, Ocean Springs, Mississippi. Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama. Food and Drug Administration, College Park, Maryland
Y1  - 2007/12/01/
PY  - 2007
DA  - 2007 Dec 01
SP  - 7589
EP  - 7596
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA
VL  - 73
IS  - 23
SN  - 0099-2240, 0099-2240
KW  - Ecology Abstracts; Aqualine Abstracts; Pollution Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts A: Industrial & Applied Microbiology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources
KW  - ASW, USA, Alabama
KW  - Coastal environments
KW  - Water Sampling
KW  - Gulfs
KW  - Public health
KW  - Salinity
KW  - Vibrio parahaemolyticus
KW  - Seasonal variations
KW  - environmental factors
KW  - annual variations
KW  - Pathogenic bacteria
KW  - Water temperature
KW  - Vibrio
KW  - Coastal zone
KW  - Oysters
KW  - Marine molluscs
KW  - Turbidity
KW  - Variability
KW  - Geographical distribution
KW  - Water sampling
KW  - Water Analysis
KW  - Infection
KW  - Environmental factors
KW  - Sulfur dioxide
KW  - oysters
KW  - Salinity effects
KW  - infection
KW  - Regression analysis
KW  - Marine
KW  - Data processing
KW  - Annual variations
KW  - Density
KW  - ASW, Mexico Gulf
KW  - ASW, USA, Mississippi
KW  - gastroenteritis
KW  - Water wells
KW  - summer
KW  - Gastroenteritis
KW  - water temperature
KW  - AQ 00001:Water Resources and Supplies
KW  - O 4020:Pollution - Organisms/Ecology/Toxicology
KW  - SW 0810:General
KW  - A 01450:Environmental Pollution & Waste Treatment
KW  - D 04040:Ecosystem and Ecology Studies
KW  - P 1000:MARINE POLLUTION
KW  - Q1 08484:Species interactions: parasites and diseases
KW  - Q5 08524:Public health, medicines, dangerous organisms
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2016-05-27
N1  - SubjectsTermNotLitGenreText - Coastal zone; Geographical distribution; Pathogenic bacteria; Annual variations; Marine molluscs; Seasonal variations; Turbidity; Public health; Data processing; Coastal environments; Salinity effects; Regression analysis; Water temperature; Gastroenteritis; Infection; Environmental factors; environmental factors; Water sampling; annual variations; Salinity; oysters; Sulfur dioxide; gastroenteritis; infection; summer; Water wells; water temperature; Variability; Vibrio; Water Analysis; Oysters; Density; Water Sampling; Gulfs; Vibrio parahaemolyticus; ASW, Mexico Gulf; ASW, USA, Mississippi; ASW, USA, Alabama; Marine
ER  - 



TY  - JOUR
T1  - Genome Sequence Analysis of the Emerging Human Pathogenic Acetic Acid Bacterium Granulibacter bethesdensis
AN  - 19900078; 7741959
AB  - Chronic granulomatous disease (CGD) is an inherited immune deficiency characterized by increased susceptibility to infection with Staphylococcus, certain gram-negative bacteria, and fungi. Granulibacter bethesdensis, a newly described genus and species within the family Acetobacteraceae, was recently isolated from four CGD patients residing in geographically distinct locales who presented with fever and lymphadenitis. We sequenced the genome of the reference strain of Granulibacter bethesdensis, which was isolated from lymph nodes of the original patient. The genome contains 2,708,355 base pairs in a single circular chromosome, in which 2,437 putative open reading frames (ORFs) were identified, 1,470 of which share sequence similarity with ORFs in the nonpathogenic but related Gluconobacter oxydans genome. Included in the 967 ORFs that are unique to G. bethesdensis are ORFs potentially important for virulence, adherence, DNA uptake, and methanol utilization. GC% values and best BLAST analysis suggested that some of these unique ORFs were recently acquired. Comparison of G. bethesdensis to other known CGD pathogens demonstrated conservation of some putative virulence factors, suggesting possible common mechanisms involved in pathogenesis in CGD. Genotyping of the four patient isolates by use of a custom microarray demonstrated genome-wide variations in regions encoding DNA uptake systems and transcriptional regulators and in hypothetical ORFs. G. bethesdensis is a genetically diverse emerging human pathogen that may have recently acquired virulence factors new to this family of organisms.
JF  - Journal of Bacteriology
AU  - Greenberg, David E
AU  - Porcella, Stephen F
AU  - Zelazny, Adrian M
AU  - Virtaneva, Kimmo
AU  - Sturdevant, Dan E
AU  - Kupko, John JIII
AU  - Barbian, Kent D
AU  - Babar, Amenah
AU  - Dorward, David W
AU  - Holland, Steven M
AD  - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892. Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Hamilton, Montana 59840. Research Technologies Section, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Hamilton, Montana 59840
Y1  - 2007/12/01/
PY  - 2007
DA  - 2007 Dec 01
SP  - 8727
EP  - 8736
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 189
IS  - 23
SN  - 0021-9193, 0021-9193
KW  - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Genetics Abstracts
KW  - Genomes
KW  - virulence factors
KW  - Genotyping
KW  - Nucleotide sequence
KW  - Fungi
KW  - Staphylococcus
KW  - Methanol
KW  - Transcription
KW  - Gluconobacter oxydans
KW  - Pathogens
KW  - DNA microarrays
KW  - Acetic acid
KW  - Lymph nodes
KW  - Fever
KW  - Guanylate cyclase
KW  - Lymphadenitis
KW  - Gram-negative bacteria
KW  - Chronic infection
KW  - DNA
KW  - Conservation
KW  - Chronic granulomatous disease
KW  - Open reading frames
KW  - J 02400:Human Diseases
KW  - N 14810:Methods
KW  - G 07770:Bacteria
KW  - K 03420:Plant Diseases
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Genome+Sequence+Analysis+of+the+Emerging+Human+Pathogenic+Acetic+Acid+Bacterium+Granulibacter+bethesdensis&rft.au=Greenberg%2C+David+E%3BPorcella%2C+Stephen+F%3BZelazny%2C+Adrian+M%3BVirtaneva%2C+Kimmo%3BSturdevant%2C+Dan+E%3BKupko%2C+John+JIII%3BBarbian%2C+Kent+D%3BBabar%2C+Amenah%3BDorward%2C+David+W%3BHolland%2C+Steven+M&rft.aulast=Greenberg&rft.aufirst=David&rft.date=2007-12-01&rft.volume=189&rft.issue=23&rft.spage=8727&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Genomes; virulence factors; Fungi; Nucleotide sequence; Genotyping; Methanol; Transcription; Pathogens; Acetic acid; DNA microarrays; Lymph nodes; Fever; Guanylate cyclase; Lymphadenitis; Gram-negative bacteria; Chronic infection; DNA; Conservation; Chronic granulomatous disease; Open reading frames; Staphylococcus; Gluconobacter oxydans
ER  - 



TY  - JOUR
T1  - Intrauterine exposures and risk of endometriosis
AN  - 19716427; 7931849
AB  - BACKGROUND: Intrauterine environmental exposures have been adversely associated with male reproductive health in contrast to limited investigation of such exposures and female reproductive health. METHODS: To address this research gap, a cohort comprising 84 women aged 18-40 years undergoing laparoscopy was recruited prior to surgery and followed through the post-operative period for endometriosis diagnosis. Women were interviewed about environmental exposures and those of their mothers while pregnant with them (use of alcohol, caffeinated beverages and cigarettes). Endometriosis was diagnosed in 32 women from the laparoscopy cohort; 52 women had no endometriosis visualized. Using unconditional logistic regression, odds ratios (OR) and 95% confidence intervals (CIs) were estimated for the intrauterine exposures adjusting for potential confounders. RESULTS: No significant associations were seen between intrauterine exposure to alcohol or caffeine and a diagnosis of endometriosis. Adjusting for age, significant reductions in odds of an endometriosis diagnosis were observed for intrauterine cigarette exposure both in the absence (OR 0.22, 95% CI 0.06-0.82) or presence (OR 0.05, 95% CI 0.01-0.42) of women's current smoking. CONCLUSIONS: While speculative, in utero cigarette exposure may be associated with a lower risk of surgically diagnosed adult-onset endometriosis, possibly as a result of alterations in hormonal milieu or pathologic angiogensis.
JF  - Human Reproduction
AU  - Buck Louis, Germaine M
AU  - Hediger, Mary L
AU  - Pena, Josefa B
AD  - Department of Health and Human Services, Epidemiology Branch, National Institute of Child Health & Human Development, 6100 Executive Blvd., Room 7B03, Rockville, Maryland 20852, USA. Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A & M University Health Science Center, College Station, Texas 77843, USA
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 3232
EP  - 3236
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 22
IS  - 12
SN  - 0268-1161, 0268-1161
KW  - Sustainability Science Abstracts
KW  - Alcohol
KW  - Age
KW  - Cigarettes
KW  - laparoscopy
KW  - Reproduction
KW  - surgery
KW  - M3 1010:Issues in Sustainable Development
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19716427?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Intrauterine+exposures+and+risk+of+endometriosis&rft.au=Buck+Louis%2C+Germaine+M%3BHediger%2C+Mary+L%3BPena%2C+Josefa+B&rft.aulast=Buck+Louis&rft.aufirst=Germaine&rft.date=2007-12-01&rft.volume=22&rft.issue=12&rft.spage=3232&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Alcohol; Age; Cigarettes; Reproduction; laparoscopy; surgery
ER  - 



TY  - JOUR
T1  - Short communication: Occurrence of multidrug resistant Salmonella in antimicrobial-free (ABF) swine production systems
AN  - 19539994; 8338366
AB  - This cross-sectional study was conducted to determine the prevalence and antimicrobial resistance of Salmonella species in swine reared in the intensive (indoor) and extensive (outdoor) ABF production systems at farm and slaughter in North Carolina, U.S.A. We sampled a total of 279 pigs at farm (extensive 107; intensive 172) and collected 274 carcass swabs (extensive 124; intensive 150) at slaughter. Salmonella species were tested for their susceptibility against 12 antimicrobial agents using the Kirby-Bauer disk diffusion method. Serogrouping was done using polyvalent and group specific antisera. A total of 400 salmonellae were isolated in this study with a significantly higher Salmonella prevalence from the intensive (30%) than the extensive farms (0.9%) (P < 0.001). At slaughter, significantly higher Salmonella was isolated at the pre- and post-evisceration stages from extensively (29% pre-evisceration and 33.3% post-evisceration) than the intensively (2% pre-evisceration and 6% post-evisceration) reared swine (P < 0.001). The isolates were clustered in six serogroups including B, C, E1, E4, G and R. Highest frequency of antimicrobial resistance was observed against tetracycline (78.5%) and streptomycin (31.5%). A total of 13 antimicrobial resistance patterns were observed including the pentaresistant strains with ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, tetracycline resistance pattern observed only among isolates from the intensive farms (n = 28) and all were serotype Salmonella typhimurium var. Copenhagen. In conclusion, this study shows that multidrug resistant Salmonella are prevalent in ABF production systems despite the absence of antimicrobial selection pressure. In addition, it also highlights the possible role played by slaughterhouse and other environmental factors in the contamination and dissemination of antimicrobial resistant Salmonella in ABF production systems.
JF  - Veterinary Microbiology
AU  - Thakur, Siddhartha
AU  - Tadesse, Daniel A
AU  - Morrow, Morgan
AU  - Gebreyes, Wondwossen A
AD  - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, United States, gebreyes.1@osu.edu
Y1  - 2007/12//
PY  - 2007
DA  - Dec 2007
SP  - 362
EP  - 367
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 125
IS  - 3-4
SN  - 0378-1135, 0378-1135
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology
KW  - Swine
KW  - Salmonella species
KW  - Antimicrobial-free production system
KW  - Antimicrobials
KW  - Multidrug resistance
KW  - Chloramphenicol
KW  - Serotypes
KW  - Farms
KW  - Sulfamethoxazole
KW  - Contamination
KW  - Drug resistance
KW  - Ampicillin
KW  - Streptomycin
KW  - Salmonella typhimurium
KW  - Tetracyclines
KW  - Environmental factors
KW  - Antimicrobial agents
KW  - Antisera
KW  - Carcasses
KW  - Diffusion
KW  - Slaughter
KW  - J 02410:Animal Diseases
KW  - A 01340:Antibiotics & Antimicrobials
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+Microbiology&rft.atitle=Short+communication%3A+Occurrence+of+multidrug+resistant+Salmonella+in+antimicrobial-free+%28ABF%29+swine+production+systems&rft.au=Thakur%2C+Siddhartha%3BTadesse%2C+Daniel+A%3BMorrow%2C+Morgan%3BGebreyes%2C+Wondwossen+A&rft.aulast=Thakur&rft.aufirst=Siddhartha&rft.date=2007-12-01&rft.volume=125&rft.issue=3-4&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Veterinary+Microbiology&rft.issn=03781135&rft_id=info:doi/10.1016%2Fj.vetmic.2007.05.025
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Chloramphenicol; Farms; Serotypes; Contamination; Sulfamethoxazole; Drug resistance; Ampicillin; Streptomycin; Tetracyclines; Environmental factors; Antimicrobial agents; Antisera; Carcasses; Slaughter; Diffusion; Salmonella typhimurium
DO  - http://dx.doi.org/10.1016/j.vetmic.2007.05.025
ER  - 



TY  - JOUR
T1  - Chronic lymphocytic leukaemia and radiation: findings among workers at five US nuclear facilities and a review of the recent literature
AN  - 1516751783; 7978354
AB  - The aetiology of chronic lymphocytic leukaemia (CLL) is largely unknown. Despite compelling evidence for ionising radiation as a cause of most forms of leukaemia, CLL was not found to be radiogenic in early studies. Herein we describe the recent evidence for causation of CLL by ionising and non-ionising radiation, including a nested case-control study conducted within a cohort of 94 517 US workers at four nuclear weapons facilities and a nuclear naval shipyard. Forty-three cases of CLL deaths and 172 age-matched controls were identified with follow-up up to between 1990 and 1996. Radiation exposure from external sources and plutonium (lagged 10 years) was assessed for each worker, based on monitoring records. The excess relative rate (ERR) was estimated for workers receiving elevated doses compared to unexposed workers, controlling for possible risk factors. The ERR per 10 mSv was -0.020 (95% confidence interval: <0, 0.14) based on all exposed workers. However, for workers receiving <100 mSv, the ERR per 10 mSv was 0.20 (-0.035, 0.96). Recent studies of uranium miners and other populations have shown elevations of CLL possibly associated with ionising and non-ionising radiation. New studies should use incident cases and sufficient latency to account for the expected lengthy induction period for CLL.
JF  - British Journal of Haematology
AU  - Schubauer-Berigan, Mary K
AU  - Daniels, Robert D
AU  - Fleming, Donald A
AU  - Markey, Andrea M
AU  - Couch, James R
AU  - Ahrenholz, Steven H
AU  - Burphy, Jenneh S
AU  - Anderson, Jeri L
AU  - Tseng, Chih-Yu
AD  - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, OH, USA, zcg3@cdc.gov
Y1  - 2007/12//
PY  - 2007
DA  - December 2007
SP  - 799
EP  - 808
PB  - Blackwell Publishing Ltd., 9600 Garsington Road
VL  - 139
IS  - 5
SN  - 0007-1048, 0007-1048
KW  - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Immunology Abstracts
KW  - chronic lymphocytic leukaemia
KW  - aetiology
KW  - epidemiology
KW  - Plutonium
KW  - Aetiology
KW  - Haematology
KW  - Workers
KW  - USA
KW  - Radiation
KW  - Literature reviews
KW  - Risk factors
KW  - Uranium
KW  - Chronic lymphatic leukemia
KW  - Occupational exposure
KW  - O 7020:Ships and Shipbuilding
KW  - F 06915:Cancer Immunology
KW  - Q5 08502:Methods and instruments
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2014-04-01
N1  - Last updated - 2016-02-04
N1  - SubjectsTermNotLitGenreText - Plutonium; Literature reviews; Uranium; Aetiology; Haematology; Workers; Radiation; Risk factors; Chronic lymphatic leukemia; Occupational exposure; USA
DO  - http://dx.doi.org/10.1111/j.1365-2141.2007.06843.x
ER  - 



TY  - JOUR
T1  - Electromagnetic compatibility of pacemakers and implantable cardiac defibrillators exposed to RFID readers
AN  - 20502502; 9196294
JF  - International Journal of Radio Frequency Identification Technology and Applications
AU  - Seidman, Seth J
AU  - Ruggera, Paul S
AU  - Brockman, Randall G
AU  - Lewis, Brian
AU  - Shein, Mitchell J
AD  - Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD 20993, USA.
Y1  - 2007/11/25/
PY  - 2007
DA  - 2007 Nov 25
SP  - 237
EP  - 246
PB  - Inderscience Publishers Ltd., PO Box 735
VL  - 1
IS  - 3
SN  - 1745-3216, 1745-3216
KW  - Biotechnology and Bioengineering Abstracts
KW  - COMPUTING JOURNALS
KW  - TECHNICAL JOURNALS
KW  - Communications and Mobile Technology
KW  - Information Systems and Technology
KW  - Materials and Manufacturing
KW  - Heart
KW  - Pacemakers
KW  - W 30965:Miscellaneous, Reviews
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20502502?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radio+Frequency+Identification+Technology+and+Applications&rft.atitle=Electromagnetic+compatibility+of+pacemakers+and+implantable+cardiac+defibrillators+exposed+to+RFID+readers&rft.au=Seidman%2C+Seth+J%3BRuggera%2C+Paul+S%3BBrockman%2C+Randall+G%3BLewis%2C+Brian%3BShein%2C+Mitchell+J&rft.aulast=Seidman&rft.aufirst=Seth&rft.date=2007-11-25&rft.volume=1&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radio+Frequency+Identification+Technology+and+Applications&rft.issn=17453216&rft_id=info:doi/10.1504%2FIJRFITA.2007.015848
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-05-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Heart; Pacemakers
DO  - http://dx.doi.org/10.1504/IJRFITA.2007.015848
ER  - 



TY  - JOUR
T1  - Brief communication: characteristics of spontaneous cases of tuberculosis associated with infliximab.
AN  - 68522532; 18025446
AB  - A warning for tuberculosis was added to the approved labeling for infliximab in October 2001.
          To describe adverse event reports of tuberculosis during infliximab therapy after labeling changes. Case series.
          Spontaneous adverse event reports maintained in the Adverse Event Reporting System database in the United States. 130 patients with infliximab-associated tuberculosis.
          Clinical and laboratory data. The U.S. Food and Drug Administration received 130 domestic, spontaneous reports of tuberculosis in patients treated with infliximab between 1 November 2001 and 30 May 2006, including 59 (45%) with extrapulmonary disease. The most commonly reported risk factors included concomitant immunosuppressant use (n = 89), history of latent or active tuberculosis (n = 33), and being born into or having spent extensive time in an area where tuberculosis is endemic (n = 25). In the subset of 67 cases with documented initiation of infliximab therapy after the drug labeling change, 34 patients with a negative tuberculin skin test result before initiation of infliximab therapy developed tuberculosis after receiving infliximab.
          Conclusions from spontaneous case reports may not be generalizable to the entire infliximab-receiving population. Clinicians should be vigilant in screening and monitoring for tuberculosis in patients receiving infliximab.
JF  - Annals of internal medicine
AU  - Raval, Angela
AU  - Akhavan-Toyserkani, Gita
AU  - Brinker, Allen
AU  - Avigan, Mark
AD  - U. S. Food and Drug Administration, Silver Spring, Maryland, USA.
Y1  - 2007/11/20/
PY  - 2007
DA  - 2007 Nov 20
SP  - 699
EP  - 702
VL  - 147
IS  - 10
KW  - Anti-Inflammatory Agents
KW  - 0
KW  - Antibodies, Monoclonal
KW  - Infliximab
KW  - B72HH48FLU
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Aged
KW  - False Negative Reactions
KW  - Adverse Drug Reaction Reporting Systems
KW  - Aged, 80 and over
KW  - Risk Factors
KW  - Adult
KW  - Immunocompromised Host
KW  - Middle Aged
KW  - Adolescent
KW  - Tuberculin Test
KW  - Female
KW  - Male
KW  - Tuberculosis -- etiology
KW  - Anti-Inflammatory Agents -- adverse effects
KW  - Tuberculosis -- immunology
KW  - Tuberculosis -- diagnosis
KW  - Antibodies, Monoclonal -- adverse effects
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68522532?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Brief+communication%3A+characteristics+of+spontaneous+cases+of+tuberculosis+associated+with+infliximab.&rft.au=Raval%2C+Angela%3BAkhavan-Toyserkani%2C+Gita%3BBrinker%2C+Allen%3BAvigan%2C+Mark&rft.aulast=Raval&rft.aufirst=Angela&rft.date=2007-11-20&rft.volume=147&rft.issue=10&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-28
N1  - Date created - 2007-11-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - Elimination Plan of Measles in Canary Islands 2001-2005
T2  - 5th World Congress of the World Society for Pediatric Infectious Diseases (WSPID 2007)
AN  - 40754856; 4771715
JF  - 5th World Congress of the World Society for Pediatric Infectious Diseases (WSPID 2007)
AU  - Rojas, A Garcia
AU  - Castellano, P Garcia
AU  - Herrera, M Trujillo
AU  - Romero, J Solis
AU  - Cruz, P Matute
AU  - Benitez, N Abadia
AU  - Santacruz, L Gonzalez
AU  - Gallo, D Nunez
AU  - Gonzalez, M.C. Perez
AU  - Capuz, B Lafarga
Y1  - 2007/11/15/
PY  - 2007
DA  - 2007 Nov 15
KW  - Atlantic, Canary Is.
KW  - Islands
KW  - Measles
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754856?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+World+Congress+of+the+World+Society+for+Pediatric+Infectious+Diseases+%28WSPID+2007%29&rft.atitle=Elimination+Plan+of+Measles+in+Canary+Islands+2001-2005&rft.au=Rojas%2C+A+Garcia%3BCastellano%2C+P+Garcia%3BHerrera%2C+M+Trujillo%3BRomero%2C+J+Solis%3BCruz%2C+P+Matute%3BBenitez%2C+N+Abadia%3BSantacruz%2C+L+Gonzalez%3BGallo%2C+D+Nunez%3BGonzalez%2C+M.C.+Perez%3BCapuz%2C+B+Lafarga&rft.aulast=Rojas&rft.aufirst=A&rft.date=2007-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+World+Congress+of+the+World+Society+for+Pediatric+Infectious+Diseases+%28WSPID+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.kenes.com/wspid2007/program/SessionIndex.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis
AN  - 19898747; 7786582
AB  - Tamoxifen is a widely used anti-estrogenic drug for chemotherapy and, more recently, for the chemoprevention of breast cancer. Despite the indisputable benefits of tamoxifen in preventing the occurrence and re-occurrence of breast cancer, the use of tamoxifen has been shown to induce non-alcoholic steatohepatitis, which is a life-threatening fatty liver disease with a risk of progression to cirrhosis and hepatocellular carcinoma. In recent years, the high-throughput microarray technology for large-scale analysis of gene expression has become a powerful tool for increasing the understanding of the molecular mechanisms of carcinogenesis and for identifying new biomarkers with diagnostic and predictive values. In the present study, we used the high-throughput microarray technology to determine the gene expression profiles in the liver during early stages of tamoxifen-induced rat hepatocarcinogenesis. Female Fisher 344 rats were fed a 420 ppm tamoxifen containing diet for 12 or 24 weeks, and gene expression profiles were determined in liver of control and tamoxifen-exposed rats. The results indicate that early stages of tamoxifen-induced liver carcinogenesis are characterized by alterations in several major cellular pathways, specifically those involved in the tamoxifen metabolism, lipid metabolism, cell cycle signaling, and apoptosis/cell proliferation control. One of the most prominent changes during early stages of tamoxifen-induced hepatocarcinogenesis is dysregulation of signaling pathways in cell cycle progression from the G sub(1) to S phase, evidenced by the progressive and sustained increase in expression of the Pdgfc, Calb3, Ets1, and Ccnd1 genes accompanied by the elevated level of the PI3K, p-PI3K, Akt1/2, Akt3, and cyclin B, D1, and D3 proteins. The early appearance of these alterations suggests their importance in the mechanism of neoplastic cell transformation induced by tamoxifen.
JF  - Toxicology and Applied Pharmacology
AU  - Pogribny, I P
AU  - Bagnyukova, T V
AU  - Tryndyak, V P
AU  - Muskhelishvili, L
AU  - Rodriguez-Juarez, R
AU  - Kovalchuk, O
AU  - Han, T
AU  - Fuscoe, J C
AU  - Ross, SA
AU  - Beland, F A
AD  - National Center for Toxicological Research, Jefferson, AR 72079, USA, igor.pogribny@fda.hhs.gov
Y1  - 2007/11/15/
PY  - 2007
DA  - 2007 Nov 15
SP  - 61
EP  - 69
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 225
IS  - 1
SN  - 0041-008X, 0041-008X
KW  - Genetics Abstracts; Toxicology Abstracts
KW  - Diets
KW  - Transformation
KW  - Molecular modelling
KW  - Apoptosis
KW  - Cirrhosis
KW  - Ets-1 protein
KW  - Chemotherapy
KW  - Cell cycle
KW  - biomarkers
KW  - Tamoxifen
KW  - Lipid metabolism
KW  - Gene expression
KW  - Cyclin B
KW  - 1-Phosphatidylinositol 3-kinase
KW  - S phase
KW  - Carcinogenesis
KW  - Fatty liver
KW  - Breast cancer
KW  - AKT1 protein
KW  - Cell proliferation
KW  - Signal transduction
KW  - Hepatocellular carcinoma
KW  - X 24310:Pharmaceuticals
KW  - G 07730:Development & Cell Cycle
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Gene+expression+profiling+reveals+underlying+molecular+mechanisms+of+the+early+stages+of+tamoxifen-induced+rat+hepatocarcinogenesis&rft.au=Pogribny%2C+I+P%3BBagnyukova%2C+T+V%3BTryndyak%2C+V+P%3BMuskhelishvili%2C+L%3BRodriguez-Juarez%2C+R%3BKovalchuk%2C+O%3BHan%2C+T%3BFuscoe%2C+J+C%3BRoss%2C+SA%3BBeland%2C+F+A&rft.aulast=Pogribny&rft.aufirst=I&rft.date=2007-11-15&rft.volume=225&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.07.001
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Transformation; Diets; Molecular modelling; Cirrhosis; Apoptosis; Ets-1 protein; Chemotherapy; Cell cycle; Tamoxifen; biomarkers; Lipid metabolism; Gene expression; 1-Phosphatidylinositol 3-kinase; Cyclin B; S phase; Carcinogenesis; AKT1 protein; Breast cancer; Fatty liver; Cell proliferation; Hepatocellular carcinoma; Signal transduction
DO  - http://dx.doi.org/10.1016/j.taap.2007.07.001
ER  - 



TY  - JOUR
T1  - Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues.
AN  - 68509434; 18003845
AB  - In humans, exposure to environmental contexts previously associated with heroin intake can provoke drug relapse, but the neuronal mechanisms mediating this relapse are unknown. Using a drug relapse model, we found previously that reexposing rats to heroin-associated contexts, after extinction of drug-reinforced responding in different contexts, reinstates heroin seeking. This effect is attenuated by inhibition of glutamate transmission in the ventral tegmental area and medial accumbens shell, components of the mesolimbic dopamine system. Here, we explored the role of dopamine of the accumbens in context-induced reinstatement by using the D1-family receptor antagonist SCH 23390 [R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride]. Rats were trained to self-administer heroin for 12 d; drug infusions were paired with a discrete tone-light cue. Subsequently, the heroin-reinforced lever pressing was extinguished in the presence of the discrete cue in a context that differed from the drug self-administration context in terms of visual, auditory, tactile, and circadian cues. When tested in the original drug self-administration context, systemic and medial or lateral accumbens shell SCH 23390 injections attenuated context-induced reinstatement of heroin seeking, whereas accumbens core SCH 23390 injections were ineffective. In contrast, core but not lateral or medial shell SCH 23390 injections attenuated discrete-cue-induced reinstatement in a nondrug context after extinction of lever presses without this cue. Results indicate that activation of medial and lateral accumbens shell D1-family dopamine receptors mediate context-induced reinstatement of heroin seeking and provide the first demonstration for a role of lateral shell dopamine in conditioned drug effects. Results also demonstrate novel dissociable roles of accumbens core and shell in context- versus discrete-cue-induced reinstatement of heroin seeking.
JF  - The Journal of neuroscience : the official journal of the Society for Neuroscience
AU  - Bossert, Jennifer M
AU  - Poles, Gabriela C
AU  - Wihbey, Kristina A
AU  - Koya, Eisuke
AU  - Shaham, Yavin
AD  - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224, USA.
Y1  - 2007/11/14/
PY  - 2007
DA  - 2007 Nov 14
SP  - 12655
EP  - 12663
VL  - 27
IS  - 46
KW  - Benzazepines
KW  - 0
KW  - Dopamine Antagonists
KW  - Receptors, Dopamine D1
KW  - Index Medicus
KW  - Animals
KW  - Benzazepines -- pharmacology
KW  - Rats, Long-Evans
KW  - Disease Models, Animal
KW  - Extinction, Psychological -- physiology
KW  - Conditioning (Psychology) -- drug effects
KW  - Rats
KW  - Behavior, Animal -- drug effects
KW  - Self Administration
KW  - Conditioning (Psychology) -- physiology
KW  - Cues
KW  - Behavior, Animal -- physiology
KW  - Benzazepines -- therapeutic use
KW  - Extinction, Psychological -- drug effects
KW  - Secondary Prevention
KW  - Male
KW  - Reward
KW  - Heroin Dependence -- metabolism
KW  - Dopamine Antagonists -- therapeutic use
KW  - Nucleus Accumbens -- drug effects
KW  - Receptors, Dopamine D1 -- antagonists & inhibitors
KW  - Heroin Dependence -- physiopathology
KW  - Dopamine Antagonists -- pharmacology
KW  - Heroin Dependence -- prevention & control
KW  - Nucleus Accumbens -- metabolism
KW  - Behavior, Addictive -- physiopathology
KW  - Nucleus Accumbens -- physiopathology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-19
N1  - Date created - 2007-11-16
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - Role of Cofilin-1 in Taurine Chloramine-Induced Premature Senescence of Human Lung Fibroblasts.
T2  - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007)
AN  - 40707161; 4755904
JF  - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007)
AU  - Zdanov, Stephanie
AU  - Shacter, Emily
Y1  - 2007/11/14/
PY  - 2007
DA  - 2007 Nov 14
KW  - Lung
KW  - Senescence
KW  - Fibroblasts
KW  - Taurine
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40707161?accountid=14244
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L2  - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - The Mitochondrially-Targeted Redox Agent Mitoquinone Enhances Doxorubicin-Induced Toxicity to Breast Cancer Cells While Protecting Cardiac Myocytes
T2  - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007)
AN  - 40705413; 4755903
JF  - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007)
AU  - Rao, V Ashutosh
AU  - Klein, Sarah
AU  - Zielonka, Jacek
AU  - Kalyanaraman, B
AU  - Shacter, Emily
Y1  - 2007/11/14/
PY  - 2007
DA  - 2007 Nov 14
KW  - Toxicity
KW  - Breast cancer
KW  - Cardiomyocytes
KW  - Mitochondria
KW  - Redox reactions
KW  - U 2000:Biological Sciences
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L2  - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Determination of Phototoxicity, Crystalline Form and Light-Induced Free Radical Formation for Tattoo Inks Containing TiO2
T2  - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007)
AN  - 40704945; 4755817
JF  - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007)
AU  - Wamer, Wayne
AU  - Yin, Jun Jie
Y1  - 2007/11/14/
PY  - 2007
DA  - 2007 Nov 14
KW  - Tattoos
KW  - Phototoxicity
KW  - Free radicals
KW  - Light effects
KW  - U 2000:Biological Sciences
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L2  - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Development of In Vitro Assay for Rapid Evaluation of Activity and Safety of New Adjuvants.
T2  - Second International Conference on Modern Vaccine / Adjuvant Formulation (MVAF 2007)
AN  - 40739101; 4770403
JF  - Second International Conference on Modern Vaccine / Adjuvant Formulation (MVAF 2007)
AU  - Zaitseva, Marina
AU  - Romantseva, Tatiana
AU  - Golding, Hana
Y1  - 2007/11/07/
PY  - 2007
DA  - 2007 Nov 07
KW  - Adjuvants
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L2  - http://www.meetingsmanagement.com/mvaf_2007/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Second Cancers Among 104760 Survivors of Cervical Cancer: Evaluation of Long-Term Risk
AN  - 20374165; 7743536
AB  - BACKGROUND: Given the extended survival of patients diagnosed with cervical cancer, the large number of these women treated with radiotherapy, and the presence in this population of established cancer risk factors such as human papillomavirus (HPV) infection and cigarette smoking, it is important to clarify long-term trends in second cancer risk. METHODS: Using data from 104760 one-year survivors of cervical cancer reported to 13 population-based cancer registries in Denmark, Finland, Norway, Sweden, and the United States, we calculated standardized incidence ratios (SIRs) for second cancers overall and cancers at particular sites among women with cervical cancer, including cervical cancer patients who were treated or not treated with radiation, over more than 40 years of follow-up. Cox regression models were used to assess the time-varying association of radiotherapy with risk of second cancers and to assess the interaction of radiation treatment with age at diagnosis. All statistical tests were two-sided. RESULTS: Among 104760 one-year survivors of cervical cancer, the risk of all second cancers taken together was increased to a statistically significant extent (n = 12496; SIR = 1.30; 95% confidence interval [CI] = 1.28 to 1.33). Compared with the general population, in both radiotherapy (N = 52613) and no-radiotherapy groups (N = 27382), risks for HPV-related cancers (of the pharynx, genital sites, and rectum/anus) and smoking-related cancers (of the pharynx, trachea/bronchus/lung, pancreas, and urinary bladder) were elevated to a statistically significant extent. Cervical cancer patients treated with radiotherapy, but not those who did not receive radiotherapy, were at increased risk for all second cancers and cancers at heavily irradiated sites (colon, rectum/anus, urinary bladder, ovary, and genital sites) beyond 40 years of follow-up compared with women in the general population. The association of radiotherapy with second cancer risk was modified by age at cervical cancer diagnosis for rectum/anus, genital sites, and urinary bladder, with higher hazard ratios for second cancer at younger ages of cervical cancer. After adjustment for competing mortality, the 40-year cumulative risk of any second cancer was higher among women diagnosed with cervical cancer before age 50 (22.2%; 95% CI = 21.5% to 22.8%) than among women diagnosed after age 50 (16.4%; 95% CI = 16.1% to 16.9%). CONCLUSION: Cervical cancer patients treated with radiotherapy are at increased risk of second cancers at sites in close proximity to the cervix beyond 40 years of follow-up.
JF  - Journal of the National Cancer Institute
AU  - Chaturvedi, Anil K
AU  - Engels, Eric A
AU  - Gilbert, Ethel S
AU  - Chen, Bingshu E
AU  - Storm, Hans
AU  - Lynch, Charles F
AU  - Hall, Per
AU  - Langmark, Froydis
AU  - Pukkala, Eero
AU  - Kaijser, Magnus
AU  - Andersson, Michael
AU  - Fossaa, Sophie D
AU  - Joensuu, Heikki
AU  - Boice, John D
AU  - Kleinerman, Ruth A
AU  - Travis, Lois B
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (AKC, EAE, ESG, BEC, RAK, LBT)
Y1  - 2007/11/07/
PY  - 2007
DA  - 2007 Nov 07
SP  - 1634
EP  - 1643
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 99
IS  - 21
SN  - 0027-8874, 0027-8874
KW  - Risk Abstracts
KW  - Mortality
KW  - Age
KW  - Finland
KW  - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir
KW  - radiotherapy
KW  - Cancer
KW  - urinary bladder
KW  - USA
KW  - Lung
KW  - Cigarette smoking
KW  - infection
KW  - Denmark
KW  - Norway
KW  - survival
KW  - Sweden
KW  - Human papillomavirus
KW  - R2 23060:Medical and environmental health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Mortality; urinary bladder; Age; Lung; Cigarette smoking; infection; survival; radiotherapy; Cancer; Human papillomavirus; USA; Finland; ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir; Denmark; Norway; Sweden
ER  - 



TY  - JOUR
T1  - Prospective Study of Serum Vitamin D and Cancer Mortality in the United States
AN  - 20373976; 7743532
AB  - BACKGROUND: Vitamin D has been hypothesized to reduce cancer mortality through its effects on incidence and/or survival. Epidemiologic studies of the association of 25-hydroxyvitamin D [25(OH)D] and the risk of cancer, however, have been largely limited to incident cancers at a few sites. METHODS: A total of 16818 participants in the Third National Health and Nutrition Examination Survey who were 17 years or older at enrollment were followed from 1988-1994 through 2000. Levels of serum 25(OH)D were measured at baseline by radioimmunoassay. Cox proportional hazards regression models were used to examine the relationship between serum 25(OH)D levels and total cancer mortality (in the entire population or according to race/ethnicity, sex, age, and retinol status) and mortality from specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season. All statistical tests were two-sided. RESULTS: We identified 536 cancer deaths in 146578 person-years. Total cancer mortality was unrelated to baseline vitamin D status in the entire population, men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans, and in persons younger than 70 or 70 years or older. We found no interaction between vitamin D and season or vitamin D and serum retinol. Colorectal cancer mortality was inversely related to serum 25(OH)D level, with levels 80 nmol/L or higher associated with a 72% risk reduction (95% confidence interval = 32% to 89%) compared with lower than 50 nmol/L, P sub(trend) = .02. CONCLUSIONS: Our results do not support an association between 25(OH)D and total cancer mortality, although there was an inverse relationship between 25(OH)D levels and colorectal cancer mortality.
JF  - Journal of the National Cancer Institute
AU  - Freedman, DMichal
AU  - Looker, Anne C
AU  - Chang, Shih-Chen
AU  - Graubard, Barry I
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (DMF, SCC, BIG)
Y1  - 2007/11/07/
PY  - 2007
DA  - 2007 Nov 07
SP  - 1594
EP  - 1602
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 99
IS  - 21
SN  - 0027-8874, 0027-8874
KW  - Risk Abstracts
KW  - Mortality
KW  - risk reduction
KW  - USA
KW  - Age
KW  - vitamins
KW  - survival
KW  - Nutrition
KW  - Cancer
KW  - Ethnic groups
KW  - R2 23060:Medical and environmental health
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N1  - SubjectsTermNotLitGenreText - risk reduction; Mortality; Age; vitamins; survival; Nutrition; Ethnic groups; Cancer; USA
ER  - 



TY  - JOUR
T1  - FDA's application of toxicological thresholds and structure activity analysis
AN  - 19466451; 8237703
JF  - Toxicology
AU  - Cheeseman, MA
AU  - Dowla, N
AU  - McDougal, A J
AU  - Yang, C
AD  - HFS-200, 5100 Paint Branch Pkwy, College Park, MD 20740, USA, Mitchell.Cheeseman@fda.hhs.gov
Y1  - 2007/11/06/
PY  - 2007
DA  - 2007 Nov 06
SP  - 130
EP  - 131
PB  - Elsevier Science, P.O. Box 85 Limerick Ireland
VL  - 240
IS  - 3
SN  - 0300-483X, 0300-483X
KW  - Toxicology Abstracts
KW  - Toxicology
KW  - X 24300:Methods
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N1  - SubjectsTermNotLitGenreText - Toxicology
DO  - http://dx.doi.org/10.1016/j.tox.2007.06.006
ER  - 



TY  - CPAPER
T1  - Glycosylation of the Dengue 2 Virus E Protein at N67 is Critical for Virus Growth in Vitro but not for Growth in Intrathoracically-Inoculated Aedes aegypti Mosquitoes
T2  - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007)
AN  - 40747873; 4776812
JF  - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007)
AU  - Roehrig, John T
AU  - Bryant, Juliet E
AU  - Calvert, Amanda E
AU  - Mesesan, Kyeen
AU  - Crabtree, Mary B
AU  - Volpe, Katharine E
AU  - Silengo, Shawn
AU  - Kinney, Richard M
AU  - Huang, Claire Y
AU  - Miller, Barry R
Y1  - 2007/11/04/
PY  - 2007
DA  - 2007 Nov 04
KW  - Dengue
KW  - E protein
KW  - Glycosylation
KW  - Public health
KW  - Aquatic insects
KW  - Growth
KW  - Aedes aegypti
KW  - Dengue virus type 2
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Innovative Health Education: Using Media and Technology to Get Today's Youth to Eat Healthy and be Physically Active
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40782194; 4784015
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Dobday, Christine
AU  - Penn, Cecilia
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Education
KW  - Technology
KW  - U 2000:Biological Sciences
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T1  - Evaluating the WOMAN Challenge: Women and Girls Out Moving Across the Nation
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40782175; 4784008 DE:
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Hoersch, Michelle D
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - U 2000:Biological Sciences
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T1  - Using Health Promoters, as Part of a School-Based Health Center Health Promotion Program, to Gain Access to Underserved and Hard-to-Reach Families
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40781940; 4784447
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Hodge, Mark
AU  - Covich, Judith
AU  - Glick, Joan
AU  - Chin, Jonathan
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Health promotion
KW  - Promoters
KW  - U 2000:Biological Sciences
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T1  - HIV/AIDS Protective Factors among Sexually Active African and Hispanic/Latino Adolescents
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40780440; 4784412
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Bellamy, Nikki D
AU  - Wang, Min Qi
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Africa
KW  - Ethnic groups
KW  - Human immunodeficiency virus
KW  - Adolescents
KW  - Acquired immune deficiency syndrome
KW  - U 2000:Biological Sciences
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T1  - Challenges of Evaluating Health Marketing Campaigns: A Look at SPOT THE BLOCK
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40777483; 4784115
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Davidson, Marjorie
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Marketing
KW  - U 2000:Biological Sciences
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T1  - Communicating Disease Prevention Information to the Public: Research-Based Guidelines for Creating Effective Web Content
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40777278; 4784014
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Hilfiker, Sandra Williams
AU  - Robison, Stacy
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Prevention
KW  - Guidelines
KW  - Public health
KW  - U 2000:Biological Sciences
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T1  - What's the Mix between Policy Decisions and Alcohol Damage: International, National, and State Perspectives
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40777165; 4784410
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Mahony, Ann
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Alcohols
KW  - Policies
KW  - U 2000:Biological Sciences
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T1  - Healthy Start: Learning Communities for Interconceptional Health
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40777116; 4783954
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Badura, Maribeth
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Learning
KW  - U 2000:Biological Sciences
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T1  - Lead Exposure among Women of Child-Bearing Age United States, 2004.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40775801; 4782024
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Luckhaupt, Sara E
AU  - Calvert, Geoffrey M
AU  - Roscoe, Robert J
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA
KW  - Lead
KW  - Age
KW  - U 2000:Biological Sciences
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T1  - Protecting Workers who Spray-On Truck Bed Liners: Understanding Audience Perceptions and Information Dissemination.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40775772; 4782021
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Hudson, Heidi
AU  - Stirnkorb, Anne
AU  - Almaguer, Dan
AU  - Ernst, Kathy
AU  - Jones, Brenda J
AU  - Ziegler, Tom E
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Perception
KW  - Trucks
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Garrett Lee Smith Memorial Campus Suicide Prevention Program: Lessons Learned and Unique Successes during the First Year
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40775427; 4784044
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Zeller, Eileen F
AU  - Davis, Nancy J
AU  - Hansen, Cynthia K
AU  - McKeon, Richard
AU  - Ritchie, Gail F
AU  - Mannix, Danyelle
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Suicide
KW  - Prevention
KW  - U 2000:Biological Sciences
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DB  - ProQuest Environmental Science Collection
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TY  - CPAPER
T1  - An Update on the OWH Pregnancy Exposure Registry Listing
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40774847; 4784009
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Sharma, Pellavi
AU  - Parekh, Ameeta
AU  - Duvall-Miller, Elizabeth
AU  - O'Leary, Connie
AU  - Uhl, Kathleen
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Pregnancy
KW  - U 2000:Biological Sciences
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DB  - ProQuest Environmental Science Collection
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TY  - CPAPER
T1  - Medicaid Asthma-Related Prescription Fills and the Associated Program Expenditures for Individuals Who had a Current Diagnosis of Asthma and an Ambulatory Service in CY 2002 Using the HHS/NIH/NHLBI NAEPP Guidelines: Age, Gender, and Race/Ethnicity Variations
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40773580; 4783834
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Benedict, M Beth
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Sex
KW  - Respiratory diseases
KW  - Asthma
KW  - Ethnic groups
KW  - Guidelines
KW  - Age
KW  - Races
KW  - Subpopulations
KW  - U 2000:Biological Sciences
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DB  - ProQuest Environmental Science Collection
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TY  - CPAPER
T1  - Dietary Supplements Labels Information for Consumers
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40771653; 4781380
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Goshorn, Jeanne C
AU  - Chang, H Florence
AU  - Moore, Dorothy R
AU  - Sun, Ying
AU  - Hudson, Vera H
AU  - Hazard, George F
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Dietary supplements
KW  - Consumers
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - How Do U.S. Consumers Handle Precut Bagged Lettuce?
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40771534; 4781450
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Lin, Chung-Tung Jordan
AU  - Verrill, Linda A
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA
KW  - Consumers
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771534?accountid=14244
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DB  - ProQuest Environmental Science Collection
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TY  - CPAPER
T1  - Environmental Justice for Immigrant Workers: Research Methods to Promote Public Health
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40770116; 4780528
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Baron, Sherry L
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Public health
KW  - Immigrants
KW  - Research methods
KW  - Environmental equity
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40770116?accountid=14244
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DB  - ProQuest Environmental Science Collection
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TY  - CPAPER
T1  - Public Reporting of HCAHPS in Context.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40769542; 4781994
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Miranda, David J
AU  - Carman, Kristin L
AU  - McGee, Jeanne
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Hospitals
KW  - U 2000:Biological Sciences
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DB  - ProQuest Environmental Science Collection
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TY  - CPAPER
T1  - Physical Workload and Low Back Disorders: Does Fairness Matter?
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40769400; 4782037
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Fujishiro, Kaori
AU  - Heaney, Catherine A
AU  - Ferguson, Sue A
AU  - Allread, W Gary
AU  - Marras, William S
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Working conditions
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769400?accountid=14244
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DB  - ProQuest Environmental Science Collection
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TY  - CPAPER
T1  - Development of a Workplace Lactation Lounge in Chicago
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40769313; 4784318
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Hoersch, Michelle D
AU  - Dolgin, Amy F
AU  - Rosenthal, Emily Gerson
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA, Illinois, Chicago
KW  - Lactation
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769313?accountid=14244
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DB  - ProQuest Environmental Science Collection
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TY  - CPAPER
T1  - Conducting an Assessment and Intervention in Houston's Inner City
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40769195; 4780427
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Vassallo, Angela
AU  - Hickenbotham, Algia
AU  - Gamble, Rick
AU  - Patterson, Pam
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Inner cities
KW  - Intervention
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769195?accountid=14244
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DB  - ProQuest Environmental Science Collection
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TY  - CPAPER
T1  - Employee Assistance and Health/Wellness Programs
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40769085; 4780144
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Galvin, Deborah
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Personnel
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Quality of Inpatient Care Provided for Older Patients with Acute Myocardial Infarction (AMI): Findings from the National Healthcare Quality Report (NHQR).
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40768627; 4781989
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Gray, Darryl T
AU  - Brady, P Jeffrey
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Myocardial infarction
KW  - Health care
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768627?accountid=14244
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TY  - CPAPER
T1  - Missed Opportunities for Prevention: Overview of Findings from the 2006 National Healthcare Quality Report.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40768591; 4781987
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Brady, P Jeffrey
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Prevention
KW  - Health care
KW  - Reviews
KW  - U 2000:Biological Sciences
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T1  - Ventilator-Associated Pneumonia among Medicare Beneficiaries in Long-Term Care Hospitals.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40768418; 4781975
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Buczko, William
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Hospitals
KW  - Ventilator-associated pneumonia
KW  - U 2000:Biological Sciences
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T1  - Variation of the Supply and Cost of Treat-and-Release Visits to Hospital Emergency Departments
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40768307; 4783721
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Friedman, Bernard
AU  - Owens, Pamela J
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Hospitals
KW  - Emergencies
KW  - U 2000:Biological Sciences
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T1  - Flu Shots at Polling Sites: Partisan Politics or Public Health?
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40767986; 4783676
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Akyea, Oyeba
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Politics
KW  - Public health
KW  - U 2000:Biological Sciences
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T1  - Evaluation of the National Breastfeeding Awareness Campaign (Babies Were Born to be Breastfed): Is Risk Susceptibility Associated with Higher Breastfeeding Rates?
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40767876; 4781400
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Haynes, Suzanne G
AU  - Merewood, Anne
AU  - Chaudhuri, Jana
AU  - Fein, Sara B
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Breast feeding
KW  - U 2000:Biological Sciences
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T1  - Prevalence and Profile of HIV Antibody Testing among High Risk Adults
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40767843; 4783600
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Bellamy, Nikki D
AU  - Wang, Min Qi
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Human immunodeficiency virus
KW  - Antibodies
KW  - Risk factors
KW  - U 2000:Biological Sciences
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T1  - Healthy People 2020: Developing National Objectives for the Next Decade
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40767828; 4784291 DE:
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Royall, Penelope
AU  - Blakey, Carter
AU  - Paxman, Dalton G
AU  - Klein, Richard
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Infant Formula use Education and Safety
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40767744; 4781451
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Labiner-Wolfe, Judith
AU  - Fein, Sara B
AU  - Shealy, Katherine
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Education
KW  - Infant formulas
KW  - U 2000:Biological Sciences
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T1  - Infant Feeding Practices Study: Methods and Sample Characteristics
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40767641; 4781395
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Fein, Sara B
AU  - Labiner-Wolfe, Judith
AU  - Shealy, Katherine
AU  - Grummer-Strawn, Laurence
AU  - Li, Ruowei
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Infants
KW  - Feeding
KW  - U 2000:Biological Sciences
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T1  - Public Health Infrastructure at Ports of Entry: Developing Effective Training Materials for U.S. Customs and Border Protection Officers
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40767446; 4780464
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Hunter, David
AU  - Benenson, Gabrielle
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA
KW  - Customs
KW  - Public health
KW  - Training
KW  - Port installations
KW  - Infrastructure
KW  - U 2000:Biological Sciences
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T1  - An Overview of the International Health Regulations (IHR): The U.S National Perspective
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40767382; 4784308
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Jajosky, Ruth
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA
KW  - Reviews
KW  - U 2000:Biological Sciences
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T1  - Healthy People 2010: Oral Health and Looking Ahead
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40767130; 4782841 DE:
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Ochiai, Emmeline
AU  - Royall, Penelope
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Widening Disparities in Infant, Neonatal, and Postneonatal Mortality among Major US Metropolitan Cities, 1985-2002
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40767074; 4783573
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Singh, Gopal K
AU  - Kogan, Michael D
AU  - Hummer, Robert A
AU  - Van Dyck, Peter C
AU  - Badura, Maribeth
AU  - Hench, Karen
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Urban areas
KW  - Mortality
KW  - Infants
KW  - Neonates
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Criminalization Hypothesis: An Historical Policy Analysis
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40766984; 4783731
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Morabito, Melissa Schaefer
AU  - Draine, Jeff
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Historical account
KW  - Policies
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Concordance of Household and Provider Reported Medical Conditions in the Medical Expenditure Panel Survey.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40766587; 4782127
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Machlin, Steven
AU  - Beauregard, Karen M
AU  - Cohen, Joel
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Households
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Health Disparities in Cancer Screening among US Women Workers.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40766524; 4782091
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Fleming, Lora E
AU  - Lee, David
AU  - Christ, Sharon L
AU  - McCollister, Kathryn E
AU  - Arheart, Kristopher L
AU  - LeBlanc, William G
AU  - Caban-Martinez, Alberto J
AU  - Chung-Bridges, Katherine
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Cancer
KW  - Screening
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Enrollment of Women and Racial Minorities in Clinical Trials for Diabetes Medications
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40766358; 4783331
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Pinnow, Ellen
AU  - Sharma, Pellavi
AU  - Parekh, Ameeta
AU  - Thomas, Kimberly
AU  - Aljuburi, Lina
AU  - Uhl, Kathleen
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Clinical trials
KW  - Diabetes mellitus
KW  - U 2000:Biological Sciences
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T1  - NIOSH Brings Industry Sector Approach to Agriculture, Forestry and Fishing Safety and Health.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40766348; 4782059
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Conway, George A
AU  - Husberg, Bradley J
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Forestry
KW  - Fishing
KW  - Agriculture
KW  - Health and safety
KW  - U 2000:Biological Sciences
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T1  - Oil and Gas Exploration and Extraction Injury Deaths: A Re-Emerging Hazard.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40766289; 4782023
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Conway, George A
AU  - Mode, Nicolle A
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Oil and gas exploration
KW  - Mortality
KW  - Injuries
KW  - Hazards
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Maternal and Child Health Initiatives in Sickle Cell Disease
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40766209; 4780843
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Lloyd-Puryear, Michele
AU  - Mann, Marie
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Sickle cell disease
KW  - U 2000:Biological Sciences
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T1  - Breast Pump use at Two, Five, and Seven Months Postpartum
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40766164; 4781398
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Labiner-Wolfe, Judith
AU  - Wang, Cunlin
AU  - Fein, Sara B
AU  - Shealy, Katherine
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Pumps
KW  - Postpartum
KW  - U 2000:Biological Sciences
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T1  - Tri Community a and I Project
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40766004; 4782416 DE:
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Gamble, Rick
AU  - Hickenbotham, Algia
AU  - Vassallo, Angela
AU  - Patterson, Pam
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Trajectories of Criminal Justice Involvement among a State Mental Health Agency's Clientele: Findings from a 10-Year Cohort Study
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40765905; 4783729
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Fisher, William H
AU  - Banks, Steven M
AU  - Roy-Bujnowski, Kristen
AU  - Clayfield, Jonathan
AU  - Grudzinskas, Albert J
AU  - Wolff, Nancy
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Mental disorders
KW  - U 2000:Biological Sciences
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T1  - A Screening and Brief Intervention Program with Alaskan Natives: The Connections SBIRT Experience
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40765770; 4780107
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Stegbauer, Thomas
AU  - Kleinschmidt, Erich
AU  - Sommer, Shannon
AU  - Naquin, Valerie
AU  - Trojan, Jodi
AU  - Cage, Brandi
AU  - Nelson, Travette
AU  - Brady, Thomas M
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Intervention
KW  - Screening
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Using Community Based Participatory Approaches to Provide Genetics Education
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40765684; 4782532
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Kyler, Panelpha
AU  - Puryear, Michele
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Genetics
KW  - Education
KW  - Community involvement
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Can the Vitamin D Needs of the North American Public be Met by Current Supplementation and Fortification Practices in the Absence of Sun Exposure?
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40765544; 4780258
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Calvo, Mona S
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - North America
KW  - Vitamin D
KW  - Sun
KW  - Supplementation
KW  - U 2000:Biological Sciences
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T1  - Smoking in the Home and Children's Health
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40765350; 4780019
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Hill, Steven C
AU  - Liang, Lan
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Smoking
KW  - Public health
KW  - U 2000:Biological Sciences
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T1  - Mental Health Issues and SAMHSA Resources
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40765255; 4782476
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Power, A.Kathryn
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Mental disorders
KW  - U 2000:Biological Sciences
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T1  - Using the IHI-Model for Improvement and a Brief Encounter Education Format to Implement Best Practices in Long Term Care Settings
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40764793; 4782644
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Bigley, Mary Beth
AU  - Simon, Lin Noyes
AU  - Lunsford, Beverly
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Education
KW  - Best practices
KW  - U 2000:Biological Sciences
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T1  - Fall-Related Hospitalizations among Elderly Medicare Beneficiaries
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40764713; 4782795
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Buczko, William
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Elderly
KW  - Geriatrics
KW  - U 2000:Biological Sciences
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T1  - Recent Developments in the National, Standardized, Publicly Reported Survey of Patients' Perspectives of Hospital Care (HCAHPS).
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40764677; 4781990
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Lehrman, William G
AU  - Goldstein, Elizabeth
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Hospitals
KW  - U 2000:Biological Sciences
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T1  - Bringing Science to Consumers: Designing Appropriate Health Education Materials
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40764612; 4784147
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Lemon, Alison
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Education
KW  - Consumers
KW  - U 2000:Biological Sciences
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T1  - Gender Differential in National Estimates for Medical Device-Associated Adverse Events from Emergency Departments
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40764266; 4783206
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Wang, Cunlin
AU  - Hefflin, Brockton
AU  - Marinica-Dabic, Danic
AU  - Loyo-Berrios, Nilsa
AU  - Zhou, Jie
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Sex
KW  - Emergencies
KW  - U 2000:Biological Sciences
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T1  - Using National Outcomes Data to Improve the Health of Seniors
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40763947; 4782773
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Bowen, Sonya E
AU  - Haffer, Samuel C
AU  - Long, William
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Aging
KW  - U 2000:Biological Sciences
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T1  - Health and Safety for Home Healthcare Workers: Politics, Policy and Public Health for a Unique Worker Population
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40763905; 4782766
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Gong, Fang
AU  - Baron, Sherry L
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Politics
KW  - Public health
KW  - Medical personnel
KW  - Policies
KW  - Health and safety
KW  - U 2000:Biological Sciences
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T1  - HRSA Funded Grantees Convened in a Strategic Process Intended to Enhance Funding Impact through Collaboration
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40763886; 4783618
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Alos, Victor
AU  - Alston, Kenneth
AU  - Roberts, Alma
AU  - Williams, Jackie
AU  - Reed-Vance, Maxine
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Financing
KW  - U 2000:Biological Sciences
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T1  - Impact of Hurricanes Katrina and Rita and their Aftermath on Substance use and Mental Illness
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40763649; 4779944
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Colpe, Lisa J
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Mental disorders
KW  - Substance use
KW  - Hurricanes
KW  - U 2000:Biological Sciences
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T1  - Disparities in Children's Health Care Quality: Findings from the 2006 National Healthcare Disparities Report
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40763497; 4783298
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Ho, Karen
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Health care
KW  - Children
KW  - U 2000:Biological Sciences
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T1  - Infant Feeding Practices Study II: Methods and Sample Characteristics
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40763471; 4783661
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Fein, Sara B
AU  - Labiner-Wolfe, Judith
AU  - Shealy, Katherine
AU  - Grummer-Strawn, Laurence
AU  - Li, Ruowei
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Infants
KW  - Feeding
KW  - U 2000:Biological Sciences
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T1  - Childrens' Pathways to Care
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40763270; 4783228
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Pfefferle, Susan G
AU  - Spitznagel, Edward L
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Mental disorders
KW  - U 2000:Biological Sciences
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T1  - U.S./Vietnam Scientific Cooperation: Building Capacity to Evaluate Agent Orange/Dioxin Soil Contamination
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40762816; 4783522
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Sweeney, Marie Haring
AU  - Farland, William H
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA
KW  - Vietnam
KW  - 2,4,5-T
KW  - Soil pollution
KW  - Dioxin
KW  - Contamination
KW  - Agent Orange
KW  - Cooperation
KW  - Chlorinated hydrocarbons
KW  - U 2000:Biological Sciences
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T1  - Lack of Planned Subgroup Analysis: Review of Drug Protocols Submitted to the Food and Drug Administration
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40762701; 4783596
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Sharma, Pellavi
AU  - Pinnow, Ellen
AU  - Scott, Pamela
AU  - Derbis, Janelle
AU  - Toigo, Theresa
AU  - Uhl, Kathleen
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Drugs
KW  - Reviews
KW  - U 2000:Biological Sciences
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T1  - Morbidity and Mortality Associated with the Nonmedical use of Dextromethorphan
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40762345; 4779946
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Crane, Elizabeth H
AU  - Poneleit, Kathy
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Mortality
KW  - Morbidity
KW  - Dextromethorphan
KW  - U 2000:Biological Sciences
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T1  - Misuse of OTC Cold and Cough Medications: New Data from NSDUH
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40762055; 4779945
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Colliver, James D
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Cough
KW  - U 2000:Biological Sciences
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T1  - Epidemiology of Invasive Pneumococcal Disease in the Era of Childhood Vaccination: Newark, New Jersey
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40761986; 4781047
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Sison, Erica J
AU  - Sinha, Anushua
AU  - Tasslimi, Azadeh
AU  - Leszczyniecka, Zofia
AU  - McGowan, Marsha
AU  - McHugh, Lisa A
AU  - Thomas, Polly
AU  - Wenger, Peter
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA, New Jersey
KW  - Children
KW  - Vaccination
KW  - Epidemiology
KW  - Streptococcus pneumoniae
KW  - U 2000:Biological Sciences
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T1  - Planning for an Urban Community Health Survey - Insights from Focus Groups in Newark, NJ
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40761030; 4781114
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Springer, M
AU  - Thomas, P A
AU  - Edwards, D
AU  - McGowan, M
AU  - Passannante, M
AU  - Rosenblum, D M
AU  - Holland, B K
AU  - Houston, S
AU  - Brown, D R
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Urban areas
KW  - U 2000:Biological Sciences
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T1  - They're Either Prepared or They're Not! Prevalence and Risk Factors for the Presence of Carbon Monoxide Alarms in Maine Households
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40760913; 4781062
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Graber, Judith M
AU  - Mittal, Prashant
AU  - Smith, Andrew E
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA, Maine
KW  - Carbon monoxide
KW  - Households
KW  - Risk factors
KW  - U 2000:Biological Sciences
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T1  - Current and Future Workforce Issues in Substance Abuse Prevention and Early Intervention in the Workplace
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40760716; 4779912
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Galvin, Deborah
AU  - Schlenger, William
AU  - Karuntzos, Georgia
AU  - Bray, Jeremy
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Prevention
KW  - Intervention
KW  - Substance abuse
KW  - Drug abuse
KW  - U 2000:Biological Sciences
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T1  - Burn Casualty Preparedness: A Program Evaluation of the Burn Asset Resource Tracking System.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40760258; 4781642
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Hsu, Sophia
AU  - Lavin, Roberta
AU  - Borden, Cheryl Ann
AU  - Bardack, Stephanie
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Burns
KW  - Tracking
KW  - U 2000:Biological Sciences
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T1  - Oral Health Takes Priority with Head Start
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40759992; 4782856
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Rossetti, John
AU  - Goodman, Harry
AU  - Jackson, Beverly Roberson
AU  - Holt, Katrina A
AU  - Geurink, Kathy
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Head
KW  - U 2000:Biological Sciences
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T1  - Premigration Factors and Mental Health among Asian Immigrants
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40759476; 4782996
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Gong, Fang
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Immigrants
KW  - Mental disorders
KW  - U 2000:Biological Sciences
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T1  - Prevalence of Obesity in Newark Adults 18 Years and Older: Using State and National Data
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40759444; 4780948
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Springer, M
AU  - Thomas, P A
AU  - O'Dowd, K J
AU  - McGowan, M
AU  - Halperin, W E
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Obesity
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Refining Estimates of Public Health Spending as Measured in National Health Expenditures Accounts.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40758908; 4781582
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Sensenig, Arthur L
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Public health
KW  - U 2000:Biological Sciences
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T1  - A Survival Comparison between HIV Positive U.S. Born Hispanics and Foreign-Born Hispanics in Houston, Texas 1990 - 2001
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40758552; 4780811
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Arafat, Raouf
AU  - Awosika-Olumo, Adebowale
AU  - Gomez, James
AU  - Wolverton, Marcia
AU  - Anderson, Lydwina
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA, Texas
KW  - USA, Texas, Houston
KW  - Ethnic groups
KW  - Human immunodeficiency virus
KW  - Survival
KW  - U 2000:Biological Sciences
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T1  - Health Disparities among Aged Hispanic Medicare Beneficiaries: The Current Perspective
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40757819; 4780889
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Greenberg, Linda G
AU  - Moy, Ernest
AU  - Borsky, Amanda E
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Ethnic groups
KW  - U 2000:Biological Sciences
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T1  - Disparities in Chronic Disease Management and Prevention: Findings from the 2006 National Healthcare Disparities Report
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40757785; 4780891
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Ho, Karen
AU  - Hines, Anika L
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Prevention
KW  - Health care
KW  - U 2000:Biological Sciences
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T1  - Evaluation of Occupation and Industry Data Collection in the NH State Cancer Registry (NHSCR)
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40757753; 4781327
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Armenti, Karla R
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Cancer
KW  - Data collection
KW  - U 2000:Biological Sciences
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T1  - Effects of Re-Injury on Military Discharge from the US Army.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40757745; 4781770
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Tiesman, Hope
AU  - Peek-Asa, Corinne
AU  - Zwerling, Craig
AU  - Whitten, Paul
AU  - Amoroso, Paul J
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Military
KW  - U 2000:Biological Sciences
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T1  - Do U.S. Consumers Know the Differences between Fats and their Relationships with Heart Disease.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40757274; 4781874
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Lin, Chung-Tung Jordan
AU  - Yen, Steven T
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA
KW  - Heart diseases
KW  - Consumers
KW  - Fats
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Gender Differences in Occupational and Non-Occupational Injuries in the U.S. Army.
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40757089; 4781769
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Tiesman, Hope
AU  - Peek-Asa, Corinne
AU  - Zwerling, Craig
AU  - Yang, Jingzhen
AU  - Amoroso, Paul J
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA
KW  - Sex
KW  - Injuries
KW  - Sex differences
KW  - U 2000:Biological Sciences
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T1  - Relationship between Illicit Drug use and Health Conditions: Results from the 2005 and 2006 National Survey on Drug use and Health
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40757059; 4779911
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Han, Beth
AU  - Colliver, James
AU  - Gfroerer, Joe
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Drug abuse
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Interdependence of Mental Health, Physical Health and Health Risk from the Maine BRFSS
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40756629; 4781188
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Freeman, Elsie
AU  - Neale, Kip
AU  - Yoe, James
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - USA, Maine
KW  - Mental disorders
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Community-Based Survey Methods and Knowledge
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40755602; 4780719
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Manning, Thomas L
AU  - Seschillie, Bess K
AU  - Elwood, Jerry
AU  - Norton, Bernice
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Community involvement
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Prevalence of Autism Spectrum Disorders in Medicaid and Associated Health Care Utilization
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40754738; 4781301
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Anderson, Karyn Kai
AU  - Mandell, David S
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Health care
KW  - Autism
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Racial and Ethnic Minority Primary Care Providers: Improving Access and Patient-Provider Communication
T2  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AN  - 40754411; 4781322
JF  - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007)
AU  - Moy, Ernest
AU  - Hogan, Sara
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Communication
KW  - U 2000:Biological Sciences
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Morris Water Maze Performance of Adult Rats Appears Insensitive to Lifetime Acrylamide Treatment
T2  - 2007 Annual Meeting of the Society for Neuroscience
AN  - 39622795; 4711321
JF  - 2007 Annual Meeting of the Society for Neuroscience
AU  - Smith, M E
AU  - Paule, M G
AU  - Garey, J D
AU  - Ferguson, S A
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Rats
KW  - Acrylamide
KW  - U 2000:Biological Sciences
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - A Chronic Stress Regimen with Unpredictable Stressor Presentation Decreases the Density of Spines on the CA3 Pyramidal Neurons of the Hippocampus in the Adult C57BL/6J Male Mouse
T2  - 2007 Annual Meeting of the Society for Neuroscience
AN  - 39619968; 4718872
JF  - 2007 Annual Meeting of the Society for Neuroscience
AU  - Miller, D B
AU  - Bachstetter, A D
AU  - Mervis, R J
AU  - Benkovic, S A
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Stress
KW  - Spine
KW  - Pyramidal cells
KW  - Hippocampus
KW  - Spines
KW  - Neurons
KW  - U 2000:Biological Sciences
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LA  - English
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N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Developmental Phencyclidine or Ketamine Treatment Significantly Slows Body Weight Gain and Alters Early Preweaning Behaviors in Sprague-Dawley Rats
T2  - 2007 Annual Meeting of the Society for Neuroscience
AN  - 39598072; 4717302
JF  - 2007 Annual Meeting of the Society for Neuroscience
AU  - Boctor, S Y
AU  - Sadovova, N
AU  - Zou, X
AU  - Wang, C
AU  - Ferguson, S
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Body weight
KW  - Rats
KW  - Body weight gain
KW  - Phencyclidine
KW  - Ketamine
KW  - U 2000:Biological Sciences
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LA  - English
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N1  - Date revised - 2007-12-18
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TY  - CPAPER
T1  - The Effects of Exogenous Activation of Proteinase-activated Receptors in the Capsaicin Induced Central Sensitization of Rats
T2  - 2007 Annual Meeting of the Society for Neuroscience
AN  - 39572016; 4706563
JF  - 2007 Annual Meeting of the Society for Neuroscience
AU  - Zhang, X
AU  - Lei, Y
AU  - Fang, L
AU  - Willis, W D
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Rats
KW  - Capsaicin
KW  - U 2000:Biological Sciences
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LA  - English
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N1  - Date revised - 2007-12-18
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ER  - 



TY  - CPAPER
T1  - Sodium Titanate Nanowires: Fabrication and Interaction with PC-12 Cells
T2  - 2007 Annual Meeting of the Society for Neuroscience
AN  - 39567421; 4711953
JF  - 2007 Annual Meeting of the Society for Neuroscience
AU  - Ali, H K
AU  - Padilla, C S
AU  - Tian, R
AU  - Duhart, H L
AU  - Ali, S F
AU  - Patterson, T A
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Sodium
KW  - U 2000:Biological Sciences
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LA  - English
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N1  - Date revised - 2007-12-18
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TY  - CPAPER
T1  - Effects of Acrylamide and Acetyl-L-carnitine on Motor Nerve Conduction Velocity and Grip Strength in Adult Rats
T2  - 2007 Annual Meeting of the Society for Neuroscience
AN  - 39563333; 4710011
JF  - 2007 Annual Meeting of the Society for Neuroscience
AU  - Garey, J D
AU  - Beaudoin, M A
AU  - Paule, M G
AU  - Skinner, R D
AU  - Binienda, Z K
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Velocity
KW  - Rats
KW  - Acrylamide
KW  - Acetyl-L-carnitine
KW  - Nerve conduction
KW  - Nerves
KW  - U 2000:Biological Sciences
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LA  - English
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N1  - Date revised - 2007-12-18
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TY  - CPAPER
T1  - Supraphysiological Levels of Corticosterone Attenuate Glial Activation and Provide Protection Against Excitotoxicity
T2  - 2007 Annual Meeting of the Society for Neuroscience
AN  - 39560358; 4706160
JF  - 2007 Annual Meeting of the Society for Neuroscience
AU  - Benkovic, S A
AU  - O'callaghan, J P
AU  - Miller, D B
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Excitotoxicity
KW  - Corticosterone
KW  - U 2000:Biological Sciences
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LA  - English
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N1  - Date revised - 2007-12-18
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ER  - 



TY  - CPAPER
T1  - Methamphetamine Dysregulates Astrocytes Functions, Increasing Oxidative Stress
T2  - 2007 Annual Meeting of the Society for Neuroscience
AN  - 39536584; 4716810
JF  - 2007 Annual Meeting of the Society for Neuroscience
AU  - Ali, S F
AU  - Jiang, H
AU  - Rongzhu, L
AU  - Milatovic, D
AU  - Aschner, M
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Oxidative stress
KW  - Methamphetamine
KW  - Astrocytes
KW  - U 2000:Biological Sciences
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
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TY  - CPAPER
T1  - The Time Course of the Scavenging of Axons in Caudate/Putamen after a Neurotoxic Amphetamine Exposure Indicates Many are of Thalamic Origin
T2  - 2007 Annual Meeting of the Society for Neuroscience
AN  - 39530415; 4711920
JF  - 2007 Annual Meeting of the Society for Neuroscience
AU  - Bowyer, J F
AU  - Schmued, L C
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Neurotoxicity
KW  - Putamen
KW  - Amphetamine
KW  - Thalamus
KW  - Axons
KW  - Neurons
KW  - U 2000:Biological Sciences
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Activation of the JAK-STAT3 Pathway is Associated with the Induction of Astrogliosis in Multiple Models of Neurotoxicity
T2  - 2007 Annual Meeting of the Society for Neuroscience
AN  - 39515255; 4713320
JF  - 2007 Annual Meeting of the Society for Neuroscience
AU  - O'callaghan, J P
AU  - Sriram, K
AU  - Benkovic, S A
AU  - Miller, D B
Y1  - 2007/11/03/
PY  - 2007
DA  - 2007 Nov 03
KW  - Neurotoxicity
KW  - Gliosis
KW  - U 2000:Biological Sciences
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Evaluation of Bone and Mineral Metabolism in Patients Recently Diagnosed With Leprosy
AN  - 746010624; 13136920
AB  - This study was conducted to evaluate patients recently diagnosed with the tuberculoid and lepromatous forms of leprosy for bone mass, bone remodeling, and hormones related to mineral control. Eleven normal control individuals (CG) and 12 patients with leprosy (LG) matched for physical characteristics were submitted to evaluation of bone mass density (BMD) and to the determination of serum levels of PTH, 25-hydroxyvitamin D [25(OH)D], testosterone, LH, FSH, osteocalcin (OC), and urinary levels of deoxypyridinoline (DPD). The T score of lumbar spine and total radius (mean c SD) were significantly lower in leprosy patients (L1-L4: CG = -0.7 c 1.5 vs LG = -1.8 c 1.0 SD, P < 0.04, and total radius: CG = -1.43 c 0.6 vs LG = -2.1 c 0.8 SD, P < 0.02), whereas no significant differences were observed in total hip or femoral neck T score. However, at all sites, the rate of low bone mass (T score < -1.0) was higher in LG (femoral neck: CG = 18% vs LG = 50%, total hip: CG = 27% vs LG = 42%). There was a significant difference in albumin and PTH levels between groups but not in serum 25(OH)D and OC levels or urinary DPD levels. The present results indicate that bone mass loss is an early event in leprosy patients and frequently is already present at diagnosis. Its etiopathogenesis is multifactorial, and further studies are needed to determine the most efficient way to prevent fractures in this condition. The data obtained in the present study need confirmation by the evaluation of a larger sample.
JF  - American Journal of the Medical Sciences
AU  - Ribeiro, F B
AU  - Pereira, FDA
AU  - Muller, E
AU  - Foss, N T
AU  - de Paula, FJA
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 322
EP  - 326
VL  - 334
IS  - 5
SN  - 0002-9629, 0002-9629
KW  - Microbiology Abstracts B: Bacteriology; Calcium & Calcified Tissue Abstracts
KW  - Physical characteristics
KW  - Data processing
KW  - Follicle-stimulating hormone
KW  - Osteocalcin
KW  - Fractures
KW  - 25-Hydroxyvitamin D
KW  - Hormones
KW  - Femur
KW  - Leprosy
KW  - Serum levels
KW  - Spine (lumbar)
KW  - Testosterone
KW  - Bone mineral density
KW  - Radius
KW  - Luteinizing hormone
KW  - Albumin
KW  - Parathyroid hormone
KW  - Bone mass
KW  - Bone remodelling
KW  - deoxypyridinoline
KW  - Metabolism
KW  - Hip
KW  - J 02400:Human Diseases
KW  - T 2025:Bone and Bone Diseases
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-07-01
N1  - Last updated - 2015-03-31
N1  - SubjectsTermNotLitGenreText - Physical characteristics; Follicle-stimulating hormone; Data processing; Osteocalcin; 25-Hydroxyvitamin D; Fractures; Femur; Hormones; Leprosy; Serum levels; Spine (lumbar); Testosterone; Bone mineral density; Radius; Luteinizing hormone; Albumin; Parathyroid hormone; Bone mass; Bone remodelling; deoxypyridinoline; Metabolism; Hip
DO  - http://dx.doi.org/10.1097/MAJ.0b013e318142bafb
ER  - 



TY  - JOUR
T1  - Gaussian representation of high-intensity focused ultrasound beams.
AN  - 742780707; pmid-18189543
AB  - A method for fast numerical simulation of high-intensity focused ultrasound beams is derived. The method is based on the frequency-domain representation of the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation, and assumes for each harmonic a Gaussian transverse pressure distribution at all distances from the transducer face. The beamwidths of the harmonics are constrained to vary inversely with the square root of the harmonic number, and as such this method may be viewed as an extension of a quasilinear approximation. The technique is capable of determining pressure or intensity fields of moderately nonlinear high-intensity focused ultrasound beams in water or biological tissue, usually requiring less than a minute of computer time on a modern workstation. Moreover, this method is particularly well suited to high-gain simulations since, unlike traditional finite-difference methods, it is not subject to resolution limitations in the transverse direction. Results are shown to be in reasonable agreement with numerical solutions of the full KZK equation in both tissue and water for moderately nonlinear beams.
JF  - The Journal of the Acoustical Society of America
AU  - Soneson, Joshua E
AU  - Myers, Matthew R
AD  - Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. joshua.soneson@fda.hhs.gov
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 2526
EP  - 2531
VL  - 122
IS  - 5
SN  - 0001-4966, 0001-4966
KW  - Index Medicus
KW  - National Library of Medicine
KW  - Computer Simulation
KW  - Humans
KW  - Algorithms
KW  - Normal Distribution
KW  - Ultrasonic Therapy
KW  - Models, Theoretical
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LA  - English (eng)
DB  - ComDisDome
N1  - Date revised - 2010-04-13
N1  - Last updated - 2010-09-25
ER  - 



TY  - JOUR
T1  - A method to quantify hand-transmitted vibration exposure based on the biodynamic stress concept.
AN  - 69086657; 18161245
AB  - This study generally hypothesized that the vibration-induced biodynamic stress and number of its cycles in a substructure of the hand-arm system play an important role in the development of vibration-induced disorders in the substructure. As the first step to test this hypothesis, the specific aims of this study were to develop a practical method to quantify the biodynamic stress-cycle measure, to compare it with ISO-weighted and unweighted accelerations, and to assess its potential for applications. A mechanical-equivalent model of the system was established using reported experimental data. The model was used to estimate the average stresses in the fingers and palm. The frequency weightings of the stresses in these substructures were derived using the proposed stress-cycle measure. This study found the frequency dependence of the average stress distributed in the fingers is different from that in the palm. Therefore, this study predicted that the frequency dependencies of finger disorders could also be different from those of the disorders in the palm, wrist, and arms. If vibration-induced white finger (VWF) is correlated better with unweighted acceleration than with ISO-weighted acceleration, the biodynamic stress distributed in the fingers is likely to play a more important role in the development of VWF than is th e biodynamic stressdistributed in the other substructures of the hand-arm system. The results of this study also suggest that the ISO weighting underestimates the high-frequency effect on the finger disorder development but it may provide a reasonable risk assessment of the disorders in the wrist and arm.
JF  - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
AU  - Dong, R G
AU  - Welcome, D E
AU  - Wu, J Z
AD  - Engineering and Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop L-2027, Morgantown, WV 26505, USA. rkd6@cdc.gov
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 847
EP  - 861
VL  - 221
IS  - 8
SN  - 0954-4119, 0954-4119
KW  - Index Medicus
KW  - Hand-Arm Vibration Syndrome -- physiopathology
KW  - Computer Simulation
KW  - Vibration
KW  - Stress, Mechanical
KW  - Humans
KW  - Energy Transfer -- physiology
KW  - Hand -- physiology
KW  - Movement -- physiology
KW  - Environmental Exposure -- analysis
KW  - Models, Biological
KW  - Biomechanical Phenomena -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-22
N1  - Date created - 2007-12-28
N1  - Date revised - 2017-02-15
N1  - Last updated - 2017-02-15
ER  - 



TY  - JOUR
T1  - Liposomal doxorubicin in combination with bortezomib for relapsed or refractory multiple myeloma.
AN  - 69062390; 18077994
AB  - On May 17, 2007, doxorubicin HCl liposome injection (Doxil) in combination with bortezomib (Velcade) received approval from the US Food and Drug Administration (FDA) for the treatment of relapsed or refractory multiple myeloma after at least one prior therapy that has not included bortezomib. Liposomal doxorubicin's efficacy and safety were demonstrated in a phase III, randomized, multicenter, international trial comparing the combination of this agent plus bortezomib vs bortezomib alone in multiple myeloma patients who had not previously received bortezomib and had received at least one prior therapy. Here we summarize the FDA review of the data that support this approval.
          An interim analysis of time to disease progression (TTP), the primary endpoint, was conducted after 249 TTP events in this study that randomized 324 patients to liposomal doxorubicin plus bortezomib treatment and 322 patients to bortezomib monotherapy. Time to progression was significantly prolonged in the combination arm (median TTP = 9.3 months) compared with bortezomib monotherapy (median TTP = 6.5 months), P < .0001 (log-rank test); hazard ratio = 0.55 (95% confidence interval = 0.43-0.71). The response rates were similar between the two arms and not statistically different; however, among responding patients, the median duration of response was longer with the combination--10.2 months compared to 7.0 months in the monotherapy arm. Adverse reactions occurred more frequently with the combination therapy. As compared to the monotherapy, frequent grade 3/4 adverse reactions with the combination were neutropenia and thrombocytopenia.
          Liposomal doxorubicin received FDA approval for use in combination with bortezomib in patients with multiple myeloma who have not previously received bortezomib and have received at least one prior therapy.
JF  - Oncology (Williston Park, N.Y.)
AU  - Ning, Yang-Min
AU  - He, Kun
AU  - Dagher, Ramzi
AU  - Sridhara, Rajeshwari
AU  - Farrell, Ann T
AU  - Justice, Robert
AU  - Pazdur, Richard
AD  - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration Silver Spring, Maryland 20993-0004, USA. ningy@cder.fda.gov
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 1503
EP  - 8; discussion 1511, 1513, 1516 passim
VL  - 21
IS  - 12
SN  - 0890-9091, 0890-9091
KW  - Antibiotics, Antineoplastic
KW  - 0
KW  - Boronic Acids
KW  - Pyrazines
KW  - Bortezomib
KW  - 69G8BD63PP
KW  - Doxorubicin
KW  - 80168379AG
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Salvage Therapy
KW  - Disease Progression
KW  - Aged
KW  - Kaplan-Meier Estimate
KW  - Aged, 80 and over
KW  - Drug Approval
KW  - Adult
KW  - Middle Aged
KW  - Female
KW  - Male
KW  - Doxorubicin -- adverse effects
KW  - Neoplasm Recurrence, Local -- drug therapy
KW  - Pyrazines -- therapeutic use
KW  - Multiple Myeloma -- drug therapy
KW  - Doxorubicin -- therapeutic use
KW  - Boronic Acids -- adverse effects
KW  - Antineoplastic Combined Chemotherapy Protocols -- adverse effects
KW  - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
KW  - Boronic Acids -- therapeutic use
KW  - Pyrazines -- adverse effects
KW  - Antibiotics, Antineoplastic -- adverse effects
KW  - Antibiotics, Antineoplastic -- therapeutic use
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-05
N1  - Date created - 2007-12-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Noise exposures during potato processing and manufacture of animal feed.
AN  - 69059213; 18075013
AB  - A noise exposure survey was conducted at an agricultural facility to evaluate noise exposures during potato processing and during the manufacture of alfalfa pellets. Of the 19 employees monitored, five reached or exceeded the National Institute for Occupational Safety and Health recommended exposure limit for occupational noise. Four of these employees were from the potato processing area, and one was from the alfalfa pellet-mill operation. Two of the five (bagger and pellet-mill operator) also exceeded the Occupational Safety and Health Administration action level. The facility has a well-managed hearing conservation program for employees in the potato processing area, but not in the alfalfa manufacturing area.
JF  - Journal of agricultural safety and health
AU  - Achutan, C
AU  - Tubbs, R L
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. cma4@cdc.gov
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 367
EP  - 374
VL  - 13
IS  - 4
SN  - 1074-7583, 1074-7583
KW  - Index Medicus
KW  - Occupational Exposure
KW  - Animals
KW  - Ear Protective Devices
KW  - Solanum tuberosum
KW  - Humans
KW  - Medicago sativa
KW  - Animal Feed
KW  - Hearing Loss, Noise-Induced -- etiology
KW  - Agricultural Workers' Diseases -- prevention & control
KW  - Agricultural Workers' Diseases -- etiology
KW  - Hearing Loss, Noise-Induced -- prevention & control
KW  - Noise, Occupational -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-15
N1  - Date created - 2007-12-13
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Erratum In:
J Agric Saf Health. 2008 Jan;14(1):table of contents
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats.
AN  - 68562892; 18047727
AB  - Pyrrolizidine alkaloids (PAs) are probably the most common plant constituents that poison livestock, wildlife, and humans worldwide. Riddelliine is isolated from plants grown in the western United States and is a prototype of genotoxic PAs. Riddelliine was used to investigate the genotoxic effects of PAs via analysis of gene expression in the target tissue of rats in this study. Previously we observed that the mutant frequency in the liver of rats gavaged with riddelliine was 3-fold higher than that in the control group. Molecular analysis of the mutants indicated that there was a statistically significant difference between the mutational spectra from riddelliine-treated and control rats.
          Riddelliine-induced gene expression profiles in livers of Big Blue transgenic rats were determined. The female rats were gavaged with riddelliine at a dose of 1 mg/kg body weight 5 days a week for 12 weeks. Rat whole genome microarray was used to perform genome-wide gene expression studies. When a cutoff value of a two-fold change and a P-value less than 0.01 were used as gene selection criteria, 919 genes were identified as differentially expressed in riddelliine-treated rats compared to the control animals. By analysis with the Ingenuity Pathway Analysis Network, we found that these significantly changed genes were mainly involved in cancer, cell death, tissue development, cellular movement, tissue morphology, cell-to-cell signaling and interaction, and cellular growth and proliferation. We further analyzed the genes involved in metabolism, injury of endothelial cells, liver abnormalities, and cancer development in detail. The alterations in gene expression were directly related to the pathological outcomes reported previously. These results provided further insight into the mechanisms involved in toxicity and carcinogenesis after exposure to riddelliine, and permitted us to investigate the interaction of gene products inside the signaling networks.
JF  - BMC bioinformatics
AU  - Mei, Nan
AU  - Guo, Lei
AU  - Liu, Ruqing
AU  - Fuscoe, James C
AU  - Chen, Tao
AD  - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. nan.mei@fda.hhs.gov
Y1  - 2007/11/01/
PY  - 2007
DA  - 2007 Nov 01
SP  - 1
VL  - 8 Suppl 7
KW  - Carcinogens
KW  - 0
KW  - Proteome
KW  - Pyrrolizidine Alkaloids
KW  - riddelliine
KW  - 23246-96-0
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Carcinogens -- administration & dosage
KW  - Carcinogenicity Tests
KW  - Liver -- drug effects
KW  - Signal Transduction -- drug effects
KW  - Proteome -- metabolism
KW  - Liver -- metabolism
KW  - Gene Expression Regulation -- drug effects
KW  - Pyrrolizidine Alkaloids -- toxicity
KW  - Gene Expression Profiling -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-29
N1  - Date created - 2007-11-30
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
BMC Bioinformatics. 2006;7 Suppl 2:S16 [17118137]
Nat Genet. 2004 Sep;36(9):969-77 [15322543]
Cancer Lett. 2004 Nov 25;215(2):151-8 [15488633]
Carcinogenesis. 1991 Mar;12(3):515-9 [2009596]
Toxicon. 1994 Aug;32(8):891-908 [7985194]
Immunol Lett. 2005 Jan 31;96(2):155-62 [15585319]
Carcinogenesis. 2005 Mar;26(3):689-99 [15618236]
Cancer Lett. 2005 Aug 8;226(1):27-35 [16004930]
Antioxid Redox Signal. 2005 Sep-Oct;7(9-10):1346-55 [16115040]
Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2480-7 [16141406]
Cancer Lett. 2006 Jan 8;231(1):138-45 [16356839]
Gene. 2006 Jan  17;366(1):128-44 [16337094]
Exp Biol Med (Maywood). 2006 Oct;231(9):1555-63 [17018880]
Nat Biotechnol. 2006 Sep;24(9):1162-9 [17061323]
Exp Clin Endocrinol Diabetes. 2006 Nov;114(10):584-9 [17177141]
Cancer Lett. 2007 Aug 8;253(1):138-43 [17324501]
BMC Bioinformatics. 2006;7 Suppl 2:S20 [17118142]
Exp Mol Pathol. 2000 Aug;69(1):17-26 [10891289]
Free Radic Biol Med. 2000 Aug;29(3-4):254-62 [11035254]
Chem Res Toxicol. 2001 Jan;14(1):91-100 [11170512]
Chem Res Toxicol. 2001 Jan;14(1):101-9 [11170513]
Clin Cancer Res. 2002 Mar;8(3):636-40 [11895890]
Int J Toxicol. 2002 Jan-Feb;21(1):7-12 [11936902]
Toxicol Appl Pharmacol. 2002 Jul 15;182(2):98-104 [12140173]
Chem Res Toxicol. 2003 Jan;16(1):66-73 [12693032]
Cancer Lett. 2003 Apr 25;193(2):119-25 [12706867]
Natl Toxicol Program Tech Rep Ser. 2003 May;(508):1-280 [12844193]
Trends Biochem Sci. 2003 Jul;28(7):377-83 [12878005]
Toxicol Lett. 2003 Oct 15;144(3):295-311 [12927348]
Chem Res Toxicol. 2003 Sep;16(9):1130-7 [12971801]
Horm Res. 2003;60(4):174-80 [14530605]
Toxicol Lett. 2003 Dec 10;145(3):239-47 [14580895]
Environ Health Perspect. 2003 Nov;111(15):1819-26 [14630514]
Mutat Res. 2003 Dec 10;533(1-2):201-9 [14643421]
Life Sci. 2004 Jan 9;74(8):935-68 [14672753]
Front Biosci. 2004 Jan 1;9:139-44 [14766353]
Drug Metab Rev. 2004 Feb;36(1):1-55 [15072438]
Chem Res Toxicol. 2004 Jun;17(6):814-8 [15206902]
Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1640-5 [15178563]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver.
AN  - 68561499; 18047722
AB  - Comfrey (Symphytum officinale) is a perennial plant and has been consumed by humans as a vegetable, a tea and an herbal medicine for more than 2000 years. It, however, is hepatotoxic and carcinogenic in experimental animals and hepatotoxic in humans. Pyrrolizidine alkaloids (PAs) exist in many plants and many of them cause liver toxicity and/or cancer in humans and experimental animals. In our previous study, we found that the mutagenicity of comfrey was associated with the PAs contained in the plant. Therefore, we suggest that carcinogenicity of comfrey result from those PAs. To confirm our hypothesis, we compared the expression of genes and processes of biological functions that were altered by comfrey (mixture of the plant with PAs) and riddelliine (a prototype of carcinogenic PA) in rat liver for carcinogenesis in this study.
          Groups of 6 Big Blue Fisher 344 rats were treated with riddelliine at 1 mg/kg body weight by gavage five times a week for 12 weeks or fed a diet containing 8% comfrey root for 12 weeks. Animals were sacrificed one day after the last treatment and the livers were isolated for gene expression analysis. The gene expressions were investigated using Applied Biosystems Rat Whole Genome Survey Microarrays and the biological functions were analyzed with Ingenuity Analysis Pathway software. Although there were large differences between the significant genes and between the biological processes that were altered by comfrey and riddelliine, there were a number of common genes and function processes that were related to carcinogenesis. There was a strong correlation between the two treatments for fold-change alterations in expression of drug metabolizing and cancer-related genes. Our results suggest that the carcinogenesis-related gene expression patterns resulting from the treatments of comfrey and riddelliine are very similar, and PAs contained in comfrey are the main active components responsible for carcinogenicity of the plant.
JF  - BMC bioinformatics
AU  - Guo, Lei
AU  - Mei, Nan
AU  - Dial, Stacey
AU  - Fuscoe, James
AU  - Chen, Tao
AD  - Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. lei.guo@fda.hhs.gov
Y1  - 2007/11/01/
PY  - 2007
DA  - 2007 Nov 01
SP  - 1
VL  - 8 Suppl 7
KW  - Carcinogens
KW  - 0
KW  - Proteome
KW  - Pyrrolizidine Alkaloids
KW  - riddelliine
KW  - 23246-96-0
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Carcinogens -- administration & dosage
KW  - Carcinogenicity Tests
KW  - Liver -- drug effects
KW  - Comfrey -- toxicity
KW  - Signal Transduction -- drug effects
KW  - Proteome -- metabolism
KW  - Liver -- metabolism
KW  - Gene Expression Regulation -- drug effects
KW  - Pyrrolizidine Alkaloids -- toxicity
KW  - Gene Expression Profiling -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-29
N1  - Date created - 2007-11-30
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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Environ Health Perspect. 2006 Jan;114(1):4-9 [16393650]
Nature. 2007 Mar 8;446(7132):153-8 [17344846]
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N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Oral treatment with ACCUTANE does not increase measures of anhedonia or depression in rats.
AN  - 68532188; 17933491
AB  - Reports of depression and/or suicide with ACCUTANE (13-cis-retinoic acid (13-cis-RA)) use prompted studies in a rodent model to ascertain its potential effects. Previously, there were no effects on measures of anhedonia (intake of a saccharin-flavored solution) and depression (forced swim test (FST) behaviors) in rats treated with 7.5 or 22.5 mg/kg 13-cis-RA [S.A. Ferguson, F.J. Cisneros, B. Gough, J.P. Hanig, K.J. Berry, Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats, Toxicol. Sci. 87 (2005) 451-459.]. Here, dose and temporal thresholds were investigated by increasing the maximum 13-cis-RA dose to 30 mg/kg, extending treatment duration, and measuring behaviors repeatedly. Beginning on post-natal day 59, male and female Sprague-Dawley rats were gavaged with soybean oil, 7.5 or 30 mg/kg/day of 13-cis-RA for approximately 19 weeks. FST behaviors were measured after 24, 82, and 131 treatment days and saccharin intake (0.03% solution) was measured at baseline and after 14, 35, 56, and 112 treatment days. Body weight and food intake were not altered by treatment. FST durations of swim, climb/struggle, and immobility were unaffected by 13-cis-RA at any time during treatment. More males than females required "rescue" in the FST but there was no treatment effect on number of rats requiring early removal. 13-cis-RA treatment had no effects on saccharin intake at any time. Given that the 7.5 mg/kg dose produces serum levels which parallel those of humans [S.A. Ferguson, P.H. Siitonen, F.J. Cisneros, B. Gough, J.F. Young, Steady state pharmacokinetics of oral treatment with 13-cis-retinoic acid or all-trans-retinoic acid in male and female adult rats, Basic Clin. Pharmacol. Toxicol 98 (2006) 582-587.], these results are quite relevant. Combined with previous results, these results provide further evidence that 13-cis-RA does not produce behavioral alterations indicative of depression in rats.
JF  - Neurotoxicology and teratology
AU  - Ferguson, Sherry A
AU  - Cisneros, F Javier
AU  - Hanig, Joseph P
AU  - Berry, Kimberly J
AD  - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079 USA. Sherry.Ferguson@fda.hhs.gov
PY  - 2007
SP  - 642
EP  - 651
VL  - 29
IS  - 6
SN  - 0892-0362, 0892-0362
KW  - Teratogens
KW  - 0
KW  - Isotretinoin
KW  - EH28UP18IF
KW  - Index Medicus
KW  - Administration, Oral
KW  - Eating -- drug effects
KW  - Animals
KW  - Swimming
KW  - Analysis of Variance
KW  - Sex Factors
KW  - Dose-Response Relationship, Drug
KW  - Disease Models, Animal
KW  - Rats
KW  - Animals, Newborn
KW  - Behavior, Animal -- drug effects
KW  - Rats, Sprague-Dawley
KW  - Drinking -- drug effects
KW  - Time Factors
KW  - Female
KW  - Male
KW  - Isotretinoin -- administration & dosage
KW  - Depression -- physiopathology
KW  - Depression -- drug therapy
KW  - Food Preferences -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-25
N1  - Date created - 2007-11-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Evaluation of a proposed area equation for improved exothermic process control.
AN  - 68522118; 17982158
AB  - Our understanding of heat transfer and meteorological theories and their applications for engineering control design have been refined since the collective work in ventilation engineering for manufacturing process was published by Hemeon in 1955. These refined theories were reviewed and used to develop a newly proposed equation to estimate buoyant plume area (A). The area is a key parameter in estimating the plume volumetric flow (Q=UA) required for exothermic process control. Subsequent to developing a theoretical equation for plume area (A), plume velocity and area data were collected in the laboratory using a thermal anemometer and a scale-model exothermic process. Laboratory results were compared to solutions provided by the proposed, American Conference of Governmental Industrial Hygienists (ACGIH) and Hemeon plume area equations to determine which equation most closely matched the laboratory data. To make this determination, either t-tests or Wilcoxon signed-rank tests were conducted (based on examination of data normality) to determine the difference between collected data and solutions from the proposed, ACGIH and Hemeon equations. Median differences and P-values from Wilcoxon signed-rank tests (non-parametric) indicate that the ACGIH and Hemeon plume area equations provide significantly lower values than the laboratory data. However, the proposed equation provided solutions that were not significantly different from the collected data. Results indicate that the plume area equations currently recommended by the ACGIH and Hemeon are not as accurate as the proposed equation over the range of parameters investigated.
JF  - The Annals of occupational hygiene
AU  - McKernan, John L
AU  - Ellenbecker, Michael J
AU  - Holcroft, Christina A
AU  - Petersen, Martin R
AD  - Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R14, Cincinnati, OH 45226, USA. jmckernan@cdc.gov
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 725
EP  - 738
VL  - 51
IS  - 8
SN  - 0003-4878, 0003-4878
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Index Medicus
KW  - Occupational Health
KW  - Equipment Design
KW  - Engineering
KW  - Air Pollutants, Occupational -- analysis
KW  - Humans
KW  - Temperature
KW  - Occupational Exposure -- prevention & control
KW  - Ventilation -- instrumentation
KW  - Models, Theoretical
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-16
N1  - Date created - 2007-11-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Evaluation of two DNA template preparation methods for post-immunomagnetic separation detection of Cryptosporidium parvum in foods and beverages by PCR.
AN  - 68487547; 17890339
AB  - Cryptosporidium parvum oocysts were recovered by immunomagnetic separation from six artificially contaminated foods. Two DNA isolation methods were subsequently evaluated by PCR. The FTA Concentrator-PS filter provided rapid and reproducible detection, although variability increased at lower inoculum levels (88% and 15% detection in high- and low-inoculum-level samples, respectively). Total DNA extraction generated consistent results at all oocyst levels but resulted in longer analysis time (100% and 59% detection in high- and low-inoculum-level samples, respectively). Also reflected in this study was that the matrix played an important role in the ability to recover oocysts, as sample turbidity, pH, and PCR inhibitors all influenced detection.
JF  - Applied and environmental microbiology
AU  - Frazar, Christian D
AU  - Orlandi, Palmer A
AD  - Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA.
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 7474
EP  - 7476
VL  - 73
IS  - 22
SN  - 0099-2240, 0099-2240
KW  - DNA, Protozoan
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Reproducibility of Results
KW  - Hydrogen-Ion Concentration
KW  - Oocysts -- metabolism
KW  - Food Parasitology
KW  - Templates, Genetic
KW  - Oocysts -- growth & development
KW  - Immunomagnetic Separation -- methods
KW  - Cryptosporidium parvum -- isolation & purification
KW  - Beverages -- parasitology
KW  - Polymerase Chain Reaction -- methods
KW  - DNA, Protozoan -- genetics
KW  - Cryptosporidium parvum -- genetics
KW  - DNA, Protozoan -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-11
N1  - Date created - 2007-11-12
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Int J Food Microbiol. 2000 Mar 25;54(3):155-62 [10777065]
MMWR Morb Mortal Wkly Rep. 2007 Mar 30;54(53):1-92 [17392681]
Vet Parasitol. 2000 Nov 10;93(2):103-12 [11035228]
J Clin Microbiol. 2000 Nov;38(11):3984-90 [11060056]
Appl Environ Microbiol. 2001 Jun;67(6):2665-8 [11375178]
J Food Prot. 2001 Nov;64(11):1793-8 [11726161]
J Microbiol Methods. 2002 May;49(3):209-24 [11869786]
J Food Prot. 2002 Aug;65(8):1345-8 [12182493]
J Microbiol Methods. 2004 Sep;58(3):375-86 [15279942]
MMWR Morb Mortal Wkly Rep. 1987 Aug 28;36(33):561-3 [3112550]
Am J Trop Med Hyg. 1991 Dec;45(6):688-94 [1763795]
N Engl J Med. 1994 Jul 21;331(3):161-7 [7818640]
Int J Food Microbiol. 1996 Sep;32(1-2):1-26 [8880324]
MMWR Morb Mortal Wkly Rep. 1997 Jan 10;46(1):4-8 [9011776]
Appl Environ Microbiol. 1997 May;63(5):2029-37 [9143132]
Am J Trop Med Hyg. 1997 Dec;57(6):683-6 [9430527]
FEMS Immunol Med Microbiol. 1999 Mar;23(3):213-20 [10219593]
Appl Environ Microbiol. 2005 Feb;71(2):898-903 [15691946]
Foodborne Pathog Dis. 2004 Winter;1(4):216-22 [15992283]
J Clin Microbiol. 2000 Jun;38(6):2271-7 [10834988]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Haff disease after eating salmon.
AN  - 68481584; 17984750
AB  - While fish consumption is considered a component of a heart-healthy diet, many illnesses have been associated with eating contaminated fish. The authors describe two cases of muscle weakness and rhabdomyolysis that occurred after eating salmon. Cases of rhabdomyolysis and muscle weakness after consumption of fresh water fish have rarely been reported in the United States but have been frequently reported from the Baltic region. This illness is known as Haff disease. While the etiology is unknown, it is felt to be a toxin. Palytoxin, found in marine fish, has been associated with rhabdomyolysis, and may serve as a model for further study of the suspected toxin responsible for rhabdomyolysis after consumption of fresh water fish. If a case of Haff disease is suspected, contact the Centers for Disease Control and Prevention and collect any uneaten fish, which may be sent for laboratory analysis.
JF  - Southern medical journal
AU  - Langley, Ricky L
AU  - Bobbitt, William H
AD  - North Carolina Department of Health and Human Services, Raleigh, North Carolina, USA. rick.langley@ncmail.net
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 1147
EP  - 1150
VL  - 100
IS  - 11
SN  - 0038-4348, 0038-4348
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Animals
KW  - Diagnosis, Differential
KW  - Humans
KW  - Aged
KW  - Middle Aged
KW  - Male
KW  - Female
KW  - Salmon
KW  - Rhabdomyolysis -- etiology
KW  - Foodborne Diseases -- etiology
KW  - Foodborne Diseases -- diagnosis
KW  - Rhabdomyolysis -- diagnosis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-08
N1  - Date created - 2007-11-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Modulation of the endocannabinoid system: therapeutic potential against cocaine dependence.
AN  - 68479251; 17945506
AB  - Dependence on cocaine is still a main unresolved medical and social concern, and in spite of research efforts, no pharmacological therapy against cocaine dependence is yet available. Recent studies have shown that the endocannabinoid system participates in specific stages and aspects of drug dependence in general, and some of this evidence suggests an involvement of the cannabinoid system in cocaine effects. For example, cocaine administration has been shown to alter brain endocannabinoid levels, and the endocannabinoid system has been involved in long-term modifications of brain processes that might play a role in neuro/behavioral effects of psychostimulant drugs like cocaine. Human studies show that marijuana dependence is frequently associated with cocaine dependence, and that the cannabinoid receptor CNR1 gene polymorphism might be related to cocaine addiction. This article will review the main papers in the field showing how a modulation of different components of the cannabinoid system might interact with some of the neurobiological/behavioral effects of cocaine related to its reinforcing effects, evaluated in preclinical models or in clinical settings. The goal of this review will be to provide insights into the complex picture of cocaine abuse and addiction, and to extrapolate from such endocannabinoid-cocaine interactions useful information to test the therapeutic potential of cannabinoid ligands and endocannabinoid-level enhancers against cocaine dependence for future preclinical/clinical trials.
JF  - Pharmacological research
AU  - Tanda, Gianluigi
AD  - Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. gtanda@intra.nida.nih.gov
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 406
EP  - 417
VL  - 56
IS  - 5
SN  - 1043-6618, 1043-6618
KW  - Cannabinoid Receptor Modulators
KW  - 0
KW  - Central Nervous System Agents
KW  - Endocannabinoids
KW  - Index Medicus
KW  - Animals
KW  - Humans
KW  - Cannabinoid Receptor Modulators -- metabolism
KW  - Cocaine-Related Disorders -- drug therapy
KW  - Central Nervous System Agents -- therapeutic use
KW  - Cocaine-Related Disorders -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-08
N1  - Date created - 2007-11-06
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Contact lens safety and the FDA: 1976 to the present.
AN  - 68462414; 17975433
AB  - The U.S. Food and Drug Administration (FDA) performs many different functions to fulfill its responsibility of regulating medical devices. The various roles in premarket and postmarket safety are discussed with representative historic events involving the regulation of contact lenses and lens care products. Current challenges facing the contact lens industry to maintain safe use of these medical devices are explained, and future pathways to address these challenges are considered.
JF  - Eye & contact lens
AU  - Saviola, James F
AD  - Office of Device Evaluation, Division of Ophthalmic and Ear, Nose, and Throat Devices, Center for Divices and Radiological Health, U.S. Food and Drug Administration, Rockville, MD 20850, USA. james.saviola@fda.hhs.gov
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 404
EP  - 9; discussion 410-1
VL  - 33
IS  - 6 Pt 2
SN  - 1542-2321, 1542-2321
KW  - Contact Lens Solutions
KW  - 0
KW  - Index Medicus
KW  - United States
KW  - Information Dissemination -- methods
KW  - Consumer Product Safety
KW  - Contact Lens Solutions -- adverse effects
KW  - Humans
KW  - Drug-Related Side Effects and Adverse Reactions
KW  - Equipment Safety
KW  - Internet
KW  - United States Food and Drug Administration -- trends
KW  - Contact Lenses -- standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-10
N1  - Date created - 2007-11-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Portable XRF analysis of occupational air filter samples from different workplaces using different samplers: final results, summary and conclusions.
AN  - 68449743; 17968454
AB  - This paper concludes a five-year program on research into the use of a portable X-ray fluorescence (XRF) analyzer for analyzing lead in air sampling filters from different industrial environments, including mining, manufacturing and recycling. The results from four of these environments have already been reported. The results from two additional metal processes are presented here. At both of these sites, lead was a minor component of the total airborne metals and interferences from other elements were minimal. Nevertheless, only results from the three sites where lead was the most abundant metal were used in the overall calculation of method accuracy. The XRF analyzer was used to interrogate the filters, which were then subjected to acid digestion and analysis by inductively-coupled plasma optical-emission spectroscopy (ICP-OES). The filter samples were collected using different filter-holders or "samplers" where the size (diameter), depth and homogeneity of aerosol deposit varied from sampler to sampler. The aerosol collection efficiencies of the samplers were expected to differ, especially for larger particles. The distribution of particles once having entered the sampler was also expected to differ between samplers. Samplers were paired to allow the between-sampler variability to be addressed, and, in some cases, internal sampler wall deposits were evaluated and compared to the filter catch. It was found, rather surprisingly, that analysis of the filter deposits (by ICP-OES) of all the samplers gave equivalent results. It was also found that deposits on some of the sampler walls, which in some protocols are considered part of the sample, could be significant in comparison to the filter deposit. If it is concluded that wall-deposits should be analyzed, then XRF analysis of the filter can only give a minimum estimate of the concentration. Techniques for the statistical analysis of field data were also developed as part of this program and have been reported elsewhere. The results, based on data from the three workplaces where lead was the major element present in the samples, are summarized here. A limit of detection and a limit of quantitation are provided. Analysis of some samples using a second analyzer with a different X-ray source technology indicated reasonable agreement for some metals (but this was not evaluated for lead). Provided it is only necessary to analyze the filters, most personal samplers will provide acceptable results when used with portable XRF analysis for lead around applicable limit values.
JF  - Journal of environmental monitoring : JEM
AU  - Harper, Martin
AU  - Pacolay, Bruce
AU  - Hintz, Patrick
AU  - Bartley, David L
AU  - Slaven, James E
AU  - Andrew, Michael E
AD  - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-3030, Morgantown, WV 26505, USA.
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 1263
EP  - 1270
VL  - 9
IS  - 11
SN  - 1464-0325, 1464-0325
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Metals
KW  - Index Medicus
KW  - Fluorescence
KW  - Filtration -- instrumentation
KW  - Metals -- analysis
KW  - Occupational Exposure
KW  - Spectrometry, X-Ray Emission -- methods
KW  - Air Pollutants, Occupational -- analysis
KW  - Workplace
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-11
N1  - Date created - 2007-10-30
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Development of a field method for measuring manganese in welding fume.
AN  - 68446802; 17968446
AB  - Workers who perform routine welding tasks are potentially exposed to fume that may contain manganese. Manganese may cause respiratory problems and is implicated in causing the occurrence of Parkinson-like symptoms. In this study, a field colorimetric method for extracting and measuring manganese in welding fume was developed. The method uses ultrasonic extraction with an acidic hydrogen peroxide solution to extract welding fume collected on polyvinyl chloride filters. Commercially available pre-packaged reagents are used to produce a colored solution, created by a reaction of manganese(ii) with 1-(2-pyridylazo)-2-naphthol. Absorbance measurements are then made using a portable spectrophotometer. The method detection limit and limit of quantification (LOQ) were 5.2 microg filter(-1) and 17 microg filter(-1), respectively, with a dynamic range up to 400 microg filter(-1). When the results are above the LOQ for the colorimetric method, the manganese masses are equivalent to those measured by the International Organization for Standardization Method 15202-2, which employs a strong acid digestion and analysis using inductively coupled plasma-optical emission spectrometry.
JF  - Journal of environmental monitoring : JEM
AU  - Dale Marcy, A
AU  - Drake, Pamela L
AD  - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Spokane Research Laboratory, 315 E. Montgomery Ave, Spokane, WA 99207, USA.
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 1199
EP  - 1204
VL  - 9
IS  - 11
SN  - 1464-0325, 1464-0325
KW  - Manganese
KW  - 42Z2K6ZL8P
KW  - Index Medicus
KW  - Sensitivity and Specificity
KW  - Occupational Exposure
KW  - Humans
KW  - Colorimetry
KW  - Manganese -- analysis
KW  - Welding
KW  - Spectrophotometry -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-11
N1  - Date created - 2007-10-30
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Pesticide dose estimates for children of Iowa farmers and non-farmers.
AN  - 68368426; 17659274
AB  - Farm children have the potential to be exposed to pesticides. Biological monitoring is often employed to assess this exposure; however, the significance of the exposure is uncertain unless doses are estimated. In the spring and summer of 2001, 118 children (66 farm, 52 non-farm) of Iowa farm and non-farm households were recruited to participate in a study investigating potential take-home pesticide exposure. Each child provided an evening and morning urine sample at two visits spaced approximately 1 month apart, with the first sample collection taken within a few days after pesticide application. Estimated doses were calculated for atrazine, metolachlor, chlorpyrifos, and glyphosate from urinary metabolite concentrations derived from the spot urine samples and compared to EPA reference doses. For all pesticides except glyphosate, the doses from farm children were higher than doses from the non-farm children. The difference was statistically significant for atrazine (p<0.0001) but only marginally significant for chlorpyrifos and metolachlor (p = 0.07 and 0.1, respectively). Among farm children, geometric mean doses were higher for children on farms where a particular pesticide was applied compared to farms where that pesticide was not applied for all pesticides except glyphosate; results were significant for atrazine (p = 0.030) and metolachlor (p = 0.042), and marginally significant for chlorpyrifos (p = 0.057). The highest estimated doses for atrazine, chlorpyrifos, metolachlor, and glyphosate were 0.085, 1.96, 3.16, and 0.34 microg/kg/day, respectively. None of the doses exceeded any of the EPA reference values for atrazine, metolachlor, and glyphosate; however, all of the doses for chlorpyrifos exceeded the EPA chronic population adjusted reference value. Doses were similar for male and female children. A trend of decreasing dose with increasing age was observed for chlorpyrifos.
JF  - Environmental research
AU  - Curwin, Brian D
AU  - Hein, Misty J
AU  - Sanderson, Wayne T
AU  - Striley, Cynthia
AU  - Heederik, Dick
AU  - Kromhout, Hans
AU  - Reynolds, Stephen J
AU  - Alavanja, Michael C
AD  - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-14, Cincinnati, OH 45226, USA. bcurwin@cdc.gov
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 307
EP  - 315
VL  - 105
IS  - 3
SN  - 0013-9351, 0013-9351
KW  - Acetamides
KW  - 0
KW  - Environmental Pollutants
KW  - Pesticides
KW  - glyphosate
KW  - 4632WW1X5A
KW  - Chlorpyrifos
KW  - JCS58I644W
KW  - Atrazine
KW  - QJA9M5H4IM
KW  - Glycine
KW  - TE7660XO1C
KW  - metolachlor
KW  - X0I01K05X2
KW  - Index Medicus
KW  - Reference Values
KW  - Humans
KW  - Child
KW  - Glycine -- analogs & derivatives
KW  - Iowa
KW  - Child, Preschool
KW  - Acetamides -- urine
KW  - Atrazine -- urine
KW  - Case-Control Studies
KW  - Glycine -- urine
KW  - Urinalysis
KW  - Adolescent
KW  - Male
KW  - Female
KW  - Chlorpyrifos -- urine
KW  - Pesticides -- analysis
KW  - Agriculture -- methods
KW  - Pesticides -- urine
KW  - Environmental Exposure -- analysis
KW  - Environmental Pollutants -- urine
KW  - Environmental Exposure -- adverse effects
KW  - Environmental Monitoring -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-03
N1  - Date created - 2007-10-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Malathion exposure and the incidence of cancer in the agricultural health study.
AN  - 68364044; 17720683
AB  - Malathion is the most common organophosphate insecticide applied in the United States, and while some studies suggest that it may be clastogenic, its carcinogenicity has not been demonstrated in rodents. However, malathion has been associated with non-Hodgkin's lymphoma in several epidemiologic studies. The authors investigated associations between malathion exposure and cancer among 19,717 pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Information on lifetime years and days per year of use and intensity of malathion exposure was obtained with self-administered questionnaires prior to the onset of any cancer. The average follow-up time was 7.5 years (1993-2002). Rate ratios and 95% confidence intervals were calculated using Poisson regression, adjusting for potential confounders. Overall, lifetime days of malathion use (top tertile of exposure, >39 days) was not associated with all cancers combined (rate ratio = 0.97, 95% confidence interval: 0.81, 1.15). The risk of non-Hodgkin's lymphoma was not associated with malathion use, although the number of cases was small. The risk of melanoma with more than 39 lifetime exposure-days was 0.39 (95% confidence interval: 0.14, 1.03). In summary, malathion exposure was not clearly associated with cancer at any of the sites examined. Although the rate ratios for melanoma were reduced, small numbers and lack of experimental evidence suggest that the observed reductions may have arisen by chance.
JF  - American journal of epidemiology
AU  - Bonner, Matthew R
AU  - Coble, Joseph
AU  - Blair, Aaron
AU  - Beane Freeman, Laura E
AU  - Hoppin, Jane A
AU  - Sandler, Dale P
AU  - Alavanja, Michael C R
AD  - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA.
Y1  - 2007/11/01/
PY  - 2007
DA  - 2007 Nov 01
SP  - 1023
EP  - 1034
VL  - 166
IS  - 9
SN  - 0002-9262, 0002-9262
KW  - Insecticides
KW  - 0
KW  - Malathion
KW  - U5N7SU872W
KW  - Index Medicus
KW  - Agriculture
KW  - Odds Ratio
KW  - Prospective Studies
KW  - International Classification of Diseases
KW  - Humans
KW  - Cohort Studies
KW  - Adult
KW  - Surveys and Questionnaires
KW  - Incidence
KW  - Confidence Intervals
KW  - Middle Aged
KW  - North Carolina -- epidemiology
KW  - Male
KW  - Iowa -- epidemiology
KW  - Female
KW  - Insecticides -- adverse effects
KW  - Malathion -- adverse effects
KW  - Agricultural Workers' Diseases -- epidemiology
KW  - Neoplasms -- chemically induced
KW  - Agricultural Workers' Diseases -- chemically induced
KW  - Neoplasms -- epidemiology
KW  - Occupational Exposure -- adverse effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Malathion+exposure+and+the+incidence+of+cancer+in+the+agricultural+health+study.&rft.au=Bonner%2C+Matthew+R%3BCoble%2C+Joseph%3BBlair%2C+Aaron%3BBeane+Freeman%2C+Laura+E%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+C+R&rft.aulast=Bonner&rft.aufirst=Matthew&rft.date=2007-11-01&rft.volume=166&rft.issue=9&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-12
N1  - Date created - 2007-10-10
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Leukemia following breast cancer: an international population-based study of 376,825 women.
AN  - 68328672; 17221155
AB  - To quantify long-term temporal trends in the excess absolute risk (EAR) of secondary leukemia among breast cancer (BC) survivors, using multivariate analyses to evaluate the effects of subtype, age at BC diagnosis, attained age, and calendar year.
          We identified 376,825 1-year survivors of BC within 4 nationwide, population-based cancer registries in Sweden, Denmark, Finland, and Norway (1943-2001). Estimates of EAR (per 100,000 person-years) were modeled using Poisson regression methods and cumulative risks calculated using a competing risk model. A total of 687 non-chronic lymphocytic leukemias (EAR = 9.05; 95% confidence interval (CI) = 7.5-10.7) was reported. Significantly elevated risks were observed for the first time for chronic myeloid leukemia (CML) (EAR = 2.06; 95% CI = 1.3-2.9) and acute lymphoblastic leukemia (ALL) (EAR = 0.62; 95% CI = 0.2-1.1), in addition to acute myeloid leukemia (AML) (EAR = 5.00; 95% CI = 3.9-6.2). Excesses of CML, ALL, AML and all leukemias combined persisted over 25 years after BC diagnosis. For all leukemias, EAR decreased with increasing calendar year (P = 0.04) of BC diagnosis. Risk for all leukemia and AML by calendar year of BC diagnosis depended on age at diagnosis. For women diagnosed with BC after 1985, the 10-year cumulative risk of leukemia for those diagnosed before and after age 50 was small, 0.10% and 0.14%, respectively.
          Although secondary leukemia is a rare event, BC survivors experience statistically significant excesses for at least 25 years after diagnosis, including CML and ALL. Decreasing leukemia risks in recent calendar years likely reflect changes in treatment.
JF  - Breast cancer research and treatment
AU  - Howard, Regan A
AU  - Gilbert, Ethel S
AU  - Chen, Bingshu E
AU  - Hall, Per
AU  - Storm, Hans
AU  - Pukkala, Eero
AU  - Langmark, Froydis
AU  - Kaijser, Magnus
AU  - Andersson, Michael
AU  - Joensuu, Heikki
AU  - Fossa, Sophie D
AU  - Travis, Lois B
AD  - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Executive Plaza South, Suite 7091, Bethesda, MD 20892, USA. reganho@mail.nih.gov
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 359
EP  - 368
VL  - 105
IS  - 3
SN  - 0167-6806, 0167-6806
KW  - Index Medicus
KW  - Leukemia, Radiation-Induced -- epidemiology
KW  - Aged, 80 and over
KW  - Risk Factors
KW  - Leukemia, Radiation-Induced -- complications
KW  - Humans
KW  - Adult
KW  - Aged
KW  - Middle Aged
KW  - Leukemia, Radiation-Induced -- diagnosis
KW  - Female
KW  - Neoplasms, Second Primary -- complications
KW  - Leukemia -- diagnosis
KW  - Neoplasms, Second Primary -- epidemiology
KW  - Breast Neoplasms -- diagnosis
KW  - Leukemia -- epidemiology
KW  - Neoplasms, Second Primary -- diagnosis
KW  - Leukemia -- complications
KW  - Breast Neoplasms -- epidemiology
KW  - Breast Neoplasms -- complications
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-09
N1  - Date created - 2007-09-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The role of exposure versus body burden data in deriving health guidance values.
AN  - 68184492; 17710608
AB  - The Agency for Toxic Substances and Disease Registry (ATSDR) derives health-based guidance values to estimate daily human exposure to hazardous substances that are likely to be without appreciable risk of adverse noncancer effects for specific routes and durations of exposure. Most of these guidance values are derived from data showing external dose/health effect relationships. However, for chemicals that persist in the body, information on body burdens may provide more accurate understanding of their toxicity. This article evaluates the exposure versus body burden approaches using 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and lead as examples.
JF  - Journal of toxicology and environmental health. Part B, Critical reviews
AU  - Pohl, Hana R
AU  - Abadin, Henry G
AU  - Jones, Dennis E
AU  - De Rosa, Christopher T
AD  - U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA. hpohl@cdc.gov
PY  - 2007
SP  - 401
EP  - 415
VL  - 10
IS  - 6
KW  - Environmental Pollutants
KW  - 0
KW  - Polychlorinated Dibenzodioxins
KW  - Lead
KW  - 2P299V784P
KW  - Index Medicus
KW  - Uncertainty
KW  - Animals
KW  - No-Observed-Adverse-Effect Level
KW  - Humans
KW  - Risk Assessment
KW  - Environmental Pollutants -- standards
KW  - Environmental Pollutants -- toxicity
KW  - Lead -- toxicity
KW  - Body Burden
KW  - Environmental Exposure -- analysis
KW  - Polychlorinated Dibenzodioxins -- toxicity
KW  - Lead -- standards
KW  - Polychlorinated Dibenzodioxins -- standards
KW  - Environmental Exposure -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-30
N1  - Date created - 2007-08-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The joint demand for health care, leisure, and commodities: Implications for health care finance and access in Vietnam
AN  - 61696439; 200813441
AB  - This paper explores linkages between the demand for health care providers and the consumption of food, non-food goods, and leisure in Vietnam, using a mixed continuous/discrete dependent variable model. Cross-price elasticities calculated from the model suggest there are strong substitution effects between health care, leisure, and certain commodities. The model allows us to explore the implications of replacing user fees with alternative forms of health care finance, such as commodity taxes. In particular, the results suggest financing public health care services with a non-food sales tax rather than user fees would be more progressive and would improve access to care. Adapted from the source document.
JF  - The Journal of Development Studies
AU  - Meyerhoefer, Chad D
AU  - Sahn, David E
AU  - Younger, Stephen D
AD  - Agency for Healthcare Research and Quality, USA
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 1475
EP  - 1500
PB  - Taylor & Francis, Abingdon UK
VL  - 43
IS  - 8
SN  - 0022-0388, 0022-0388
KW  - Taxation
KW  - Leisure
KW  - Commodities
KW  - Health Care Services
KW  - Supply and Demand
KW  - Vietnam
KW  - article
KW  - 2045: sociology of health and medicine; sociology of medicine & health care
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LA  - English
DB  - Sociological Abstracts
N1  - Date revised - 2008-05-02
N1  - Number of references - 30
N1  - Last updated - 2016-09-28
N1  - CODEN - JDVSA9
N1  - SubjectsTermNotLitGenreText - Vietnam; Supply and Demand; Health Care Services; Leisure; Commodities; Taxation
DO  - http://dx.doi.org/10.1080/00220380701611527
ER  - 



TY  - JOUR
T1  - Perceptions of Americans and the Iraq Invasion: Implications for Understanding National Character Stereotypes
AN  - 57231745; 200809432
AB  - This study examines perceptions of the 'typical American' from 49 cultures around the world. Contrary to the ethnocentric bias hypothesis, a strong agreement was found between in-group and out-group ratings on the American profile (assertive, open-minded, but antagonistic). In fact, Americans had a somewhat less desirable view of Americans than did others. Within cultures, in-group ratings were not systematically more favorable than out-group ratings. The Iraq invasion had a slight negative effect on perceptions of the typical American, but people around the world seem to draw a clear distinction between U.S. foreign policy and the character of the American people. National character stereotypes appear to have a variety of sources and to be perpetuated by both cognitive mechanisms and sociocultural forces. [Reprinted by permission of Sage Publications Inc., copyright 2007.]
JF  - Journal of Cross-Cultural Psychology
AU  - Terracciano, Antonio
AU  - McCrae, Robert R
AD  - National Institute on Aging, National Institutes of Health, Department of Health and Human Services terraccianoa@grc.nia.nih.gov
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 695
EP  - 710
PB  - Sage Publications, Thousand Oaks
VL  - 38
IS  - 6
SN  - 0022-0221, 0022-0221
KW  - Foreign policy
KW  - American people
KW  - Perceptions
KW  - Wars
KW  - National identity
KW  - Stereotypes
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57231745?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Psychology&rft.atitle=Perceptions+of+Americans+and+the+Iraq+Invasion%3A+Implications+for+Understanding+National+Character+Stereotypes&rft.au=Terracciano%2C+Antonio%3BMcCrae%2C+Robert+R&rft.aulast=Terracciano&rft.aufirst=Antonio&rft.date=2007-11-01&rft.volume=38&rft.issue=6&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Psychology&rft.issn=00220221&rft_id=info:doi/10.1177%2F0022022107308586
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-05-02
N1  - Last updated - 2016-09-27
N1  - CODEN - JCPGB5
N1  - SubjectsTermNotLitGenreText - National identity; Wars; Perceptions; American people; Stereotypes; Foreign policy
DO  - http://dx.doi.org/10.1177/0022022107308586
ER  - 



TY  - JOUR
T1  - Assessment, Authorization and Access to Medicaid Managed Mental Health Care
AN  - 57218660; 200804663
AB  - Examined were effects on access of managed care assessment and authorization processes in California's 57 county mental health plans. Primary data on managed care implementation were collected from surveys of county plan administrators; secondary data were from Medicaid claims and enrollment files. Using multivariate fixed effects regression, we found that following implementation of managed care, greater access occurred in county plans where assessments and treatment were performed by the same clinician, and where service authorizations were made more rapidly. Lower access occurred in county plans where treating clinicians authorized services themselves. Results confirm the significant effects of managed care processes on outcomes and highlight the importance of system capacity. Adapted from the source document.
JF  - Administration and Policy in Mental Health AND Mental Health Services Research
AU  - Masland, Mary C
AU  - Snowden, Lonnie R
AU  - Wallace, Neal T
AD  - Department of Psychology, Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, 2140 Shattuck Ave, #409, Berkeley, CA 94720-1414, USA mmasland@berkeley.edu
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 548
EP  - 562
PB  - Springer, Dordrecht The Netherlands
VL  - 34
IS  - 6
SN  - 0894-587X, 0894-587X
KW  - Assessment
KW  - Managed care
KW  - Managed mental health care
KW  - Enrollment
KW  - Medicaid
KW  - Access
KW  - article
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Assessment%2C+Authorization+and+Access+to+Medicaid+Managed+Mental+Health+Care&rft.au=Masland%2C+Mary+C%3BSnowden%2C+Lonnie+R%3BWallace%2C+Neal+T&rft.aulast=Masland&rft.aufirst=Mary&rft.date=2007-11-01&rft.volume=34&rft.issue=6&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-007-0138-7
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-03-04
N1  - Last updated - 2016-09-27
N1  - CODEN - APMHEM
N1  - SubjectsTermNotLitGenreText - Managed care; Assessment; Access; Medicaid; Enrollment; Managed mental health care
DO  - http://dx.doi.org/10.1007/s10488-007-0138-7
ER  - 



TY  - JOUR
T1  - Development and application of reservoir models and artificial neural networks for optimizing ventilation air requirements in development mining of coal seams
AN  - 51244734; 2008-069547
AB  - In longwall development mining of coal seams, planning, optimizing and providing adequate ventilation are very important steps to eliminate the accumulation of explosive methane-air mixtures in the working environment. Mine operators usually try to supply maximum ventilation air based on the capacity of the system and the predicted need underground. This approach is neither economical nor safer as ventilation capacity may decrease in time depending on various mining and coalbed parameters. Thus, it is important to develop better engineered approaches to optimize mine ventilation effectiveness and, therefore, to ensure a safer work environment. This study presents an approach using coalbed methane reservoir modeling and an artificial neural network (ANN) design for prediction and optimization of methane inflows and ventilation air requirements to maintain methane concentrations below statutory limits. A coalbed reservoir model of a three-entry development section, which is typical of Pittsburgh Coalbed mines in the Southwestern Pennsylvania section of Northern Appalachian Basin, was developed taking into account the presence and absence of shielding boreholes around the entries against methane inflow. In the model, grids were dynamically controlled to simulate the advance of mining for parametric simulations. Development and application of artificial neural networks as an optimization tool for ventilation requirements are introduced. Model predictions are used to develop, train, and test artificial neural networks to optimize ventilation requirements. The sensitivity and applications of proposed networks for predicting simulator data are presented and discussed. Results show that reservoir simulations and integrated ANN models can be practical and powerful tools for predicting methane emissions and optimization of ventilation air requirements.
JF  - International Journal of Coal Geology
AU  - Karacan, C Ozgen
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 221
EP  - 239
PB  - Elsevier, Amsterdam
VL  - 72
IS  - 3-4
SN  - 0166-5162, 0166-5162
KW  - United States
KW  - North America
KW  - mining
KW  - mines
KW  - numerical models
KW  - underground mining
KW  - natural gas
KW  - coal mines
KW  - optimization
KW  - Appalachians
KW  - petroleum
KW  - coal seams
KW  - reservoir rocks
KW  - ventilation
KW  - artificial intelligence
KW  - boreholes
KW  - Appalachian Basin
KW  - coalbed methane
KW  - applications
KW  - neural networks
KW  - Pennsylvania
KW  - 29A:Economic geology, geology of energy sources
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Development+and+application+of+reservoir+models+and+artificial+neural+networks+for+optimizing+ventilation+air+requirements+in+development+mining+of+coal+seams&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2007-11-01&rft.volume=72&rft.issue=3-4&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2007.02.003
L2  - http://www.sciencedirect.com/science/journal/01665162
LA  - English
DB  - GeoRef
N1  - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands
N1  - Date revised - 2008-01-01
N1  - Number of references - 24
N1  - Document feature - illus. incl. 6 tables
N1  - Last updated - 2012-06-07
N1  - SubjectsTermNotLitGenreText - Appalachian Basin; Appalachians; applications; artificial intelligence; boreholes; coal mines; coal seams; coalbed methane; mines; mining; natural gas; neural networks; North America; numerical models; optimization; Pennsylvania; petroleum; reservoir rocks; underground mining; United States; ventilation
DO  - http://dx.doi.org/10.1016/j.coal.2007.02.003
ER  - 



TY  - JOUR
T1  - Swelling-induced volumetric strains internal to a stressed coal associated with CO (sub 2) sorption
AN  - 51244710; 2008-069546
AB  - It is generally accepted that typical coalbed gases (methane and carbon dioxide) are sorbed (both adsorbed and absorbed) in the coal matrix causing it to swell and resulting in local stress and strain variations in a coalbed confined under overburden pressure. The swelling, interactions of gases within the coal matrix and the resultant changes in the permeability, sorption, gas flow mechanics in the reservoir, and stress state of the coal can impact a number of reservoir-related factors. These include effective production of coalbed methane, degasification of future mining areas by drilling horizontal and vertical degasification wells, injection of CO (sub 2) as an enhanced coalbed methane recovery technique, and concurrent CO (sub 2) sequestration. Such information can also provide an understanding of the mechanisms behind gas outbursts in underground coal mines. The spatio-temporal volumetric strains in a consolidated Pittsburgh seam coal sample were evaluated while both confining pressure and carbon dioxide (CO (sub 2) ) pore pressure were increased to keep a constant positive effective stress on the sample. The changes internal to the sample were evaluated by maps of density and atomic number determined by dual-energy X-ray computed tomography (X-ray CT). Early-time images, as soon as CO (sub 2) was introduced, were also used to calculate the macroporosity in the coal sample. Scanning electron microscopy (SEM) and photographic images of the polished section of the coal sample at X-ray CT image location were used to identify the microlithotypes and microstructures. The CO (sub 2) sorption-associated swelling and volumetric strains in consolidated coal under constant effective stress are heterogeneous processes depending on the lithotypes present. In the time scale of the experiment, vitrite showed the highest degree of swelling due to dissolution of CO (sub 2) , while the clay (kaolinite) and inertite region was compressed in response. The volumetric strains associated with swelling and compression were between + or -15% depending on the location. Although the effective stress on the sample was constant, it varied within the sample as a result of the internal stresses created by gas sorption-related structural changes. SEM images and porosity calculations revealed that the kaolinite and inertite bearing layer was highly porous, which enabled the fastest CO (sub 2) uptake and the highest degree of compression.
JF  - International Journal of Coal Geology
AU  - Karacan, C Ozgen
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 209
EP  - 220
PB  - Elsevier, Amsterdam
VL  - 72
IS  - 3-4
SN  - 0166-5162, 0166-5162
KW  - United States
KW  - silicates
KW  - horizontal drilling
KW  - sorption
KW  - Pittsburgh Coal
KW  - strain
KW  - Pennsylvanian
KW  - natural gas
KW  - petroleum
KW  - carbon dioxide
KW  - sedimentary rocks
KW  - coal
KW  - directional drilling
KW  - drilling
KW  - degassing
KW  - mines
KW  - inertite
KW  - carbon sequestration
KW  - Paleozoic
KW  - stress
KW  - coal mines
KW  - Carboniferous
KW  - kaolinite
KW  - recovery
KW  - gases
KW  - clay minerals
KW  - X-ray data
KW  - volume
KW  - coalbed methane
KW  - petrography
KW  - sheet silicates
KW  - Pennsylvania
KW  - computed tomography data
KW  - SEM data
KW  - 29A:Economic geology, geology of energy sources
KW  - 06B:Petrology of coal
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L2  - http://www.sciencedirect.com/science/journal/01665162
LA  - English
DB  - GeoRef
N1  - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands
N1  - Date revised - 2008-01-01
N1  - Number of references - 31
N1  - Document feature - illus. incl. 1 table
N1  - Last updated - 2012-06-07
N1  - SubjectsTermNotLitGenreText - carbon dioxide; carbon sequestration; Carboniferous; clay minerals; coal; coal mines; coalbed methane; computed tomography data; degassing; directional drilling; drilling; gases; horizontal drilling; inertite; kaolinite; mines; natural gas; Paleozoic; Pennsylvania; Pennsylvanian; petrography; petroleum; Pittsburgh Coal; recovery; sedimentary rocks; SEM data; sheet silicates; silicates; sorption; strain; stress; United States; volume; X-ray data
DO  - http://dx.doi.org/10.1016/j.coal.2007.01.003
ER  - 



TY  - JOUR
T1  - Methods for determining roof fall risk in underground mines
AN  - 51017188; 2008-088171
AB  - Reducing the number of roof fall injuries is a goal of the NIOSH mine safety research program. Central to this effort is the development of assessment techniques to help identify the nature of the risks associated with working under potentially hazardous roof conditions. This paper discusses a method to determine the roof fall risk using a qualitative risk-analysis technique. The ability to determine roof fall risk has been a long-standing goal of safety professionals and could provide the kind of information needed by on-site personnel responsible for worker safety to mitigate roof fall injuries.
JF  - Mining Engineering
AU  - Iannacchione, A
AU  - Prosser, I
AU  - Esterhuizen, G
AU  - Bajpayee, T
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 47
EP  - 53
PB  - Society for Mining, Metallurgy, and Exploration, Littleton, CO
VL  - 59
IS  - 11
SN  - 0026-5187, 0026-5187
KW  - mining
KW  - mines
KW  - monitoring
KW  - geologic hazards
KW  - underground mining
KW  - roof control
KW  - statistical analysis
KW  - prediction
KW  - standardization
KW  - safety
KW  - risk assessment
KW  - probability
KW  - 30:Engineering geology
KW  - 22:Environmental geology
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L2  - http://me.smenet.org/
LA  - English
DB  - GeoRef
N1  - Copyright - GeoRef, Copyright 2012, American Geosciences Institute.
N1  - Date revised - 2008-01-01
N1  - Number of references - 19
N1  - PubXState - CO
N1  - Document feature - illus. incl. 6 tables
N1  - Last updated - 2012-06-07
N1  - CODEN - MIENAB
N1  - SubjectsTermNotLitGenreText - geologic hazards; mines; mining; monitoring; prediction; probability; risk assessment; roof control; safety; standardization; statistical analysis; underground mining
ER  - 



TY  - JOUR
T1  - Outcomes of a randomized trial of continuum of care services for children in a child welfare system
AN  - 37023345; 3803945
AB  - The Connecticut Department of Children and Families Title IV-E waiver demonstration evaluated whether the well-being of children approved for residential mental health services could be improved, and lengths of stay in restrictive placements reduced, by providing case rate payments to community agencies to provide continuum of care services. Children between ages 7 and 15 were randomly assigned to either the demonstration group (n = 78) or to usual state-supported services (n = 79). One-year outcome results indicated that in a situation that is less costly, improvement in outcomes occurred in less restrictive settings. Continuum of care services were more effective in 1) returning children to in-home placements, 2) reducing the length of stay in restrictive placements, and (3) utilizing higher levels of case management through coordination among agencies and family support services. © (2007) Child Welfare League of America. Reprinted by permission
JF  - Child welfare
AU  - Holden, E Wayne
AU  - O'Connell, Susan Rousseau
AU  - Liao, Qinghong
AU  - Krivelyova, Anna
AU  - Connor, Tim
AU  - Blau, Gary M
AU  - Long, Dorian
AD  - RTI International ; Community Health Resources, Connecticut ; MACRO International, Atlanta ; University of Wisconsin ; US Substance Abuse and Mental Health Services Administration
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 89
EP  - 114
VL  - 86
IS  - 6
SN  - 0009-4021, 0009-4021
KW  - Sociology
KW  - U.S.A.
KW  - Evaluation
KW  - Family policy
KW  - Surveys
KW  - Mental health
KW  - Social policy
KW  - Child care
KW  - Connecticut
KW  - Child welfare
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+welfare&rft.atitle=Outcomes+of+a+randomized+trial+of+continuum+of+care+services+for+children+in+a+child+welfare+system&rft.au=Holden%2C+E+Wayne%3BO%27Connell%2C+Susan+Rousseau%3BLiao%2C+Qinghong%3BKrivelyova%2C+Anna%3BConnor%2C+Tim%3BBlau%2C+Gary+M%3BLong%2C+Dorian&rft.aulast=Holden&rft.aufirst=E&rft.date=2007-11-01&rft.volume=86&rft.issue=6&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Child+welfare&rft.issn=00094021&rft_id=info:doi/
LA  - English
DB  - International Bibliography of the Social Sciences (IBSS)
N1  - Date revised - 2013-06-12
N1  - Last updated - 2013-09-16
N1  - SubjectsTermNotLitGenreText - 7947 5772 7954; 4774 9874 5574 10472 11888; 12429; 4551; 2192; 2208 2212; 11888 10472; 97 433 293 14
ER  - 



TY  - RPRT
T1  - TOXICOLOGY AND CARCINOGENESIS: STUDIES OF [alpha]-METHYLSTYRENE (CAS NO. 98-83-9) IN F344/N RATS AND B6C3F^sub 1^ MICE (INHALATION STUDIES)
AN  - 236521020; 18685715
AB  - α-Methylstyrene is used to make heat-resistant acrylonitrile-butathene-styrene resins and polymers. We studied the effects of a-methylstyrene on male and female rats and mice to identify potential toxic or cancer-related hazards. We exposed groups of 50 male and female rats to atmospheres containing 100, 300, or 1,000 parts per million (ppm) of a-methylstyrene 6 hours per day, 5 days a week for 2 years. Groups of 50 male and female mice were similarly exposed to atmospheres containing 100, 300, or 600 ppm a-methylstyrene. Control animals were housed in exposure chambers for similar periods but with no test chemical in their air. At the end of the study, tissues from more than 40 sites were examined for every animal. Survival was similar for animals receiving a-methylstyrene and the controls, but the average body weight for each animal group receiving the highest concentration of a-methylstyrene was less than that for the control group. Male rats exposed to a-methylstyrene had increased rates of tumors of the kidney and a slightly increased rate of mononuclear cell leukemia. Female mice exposed to a-methylstyrene had increased rates of a variety of liver cancers, and male mice also had slightly increased rates of liver tumors. We conclude that exposure to a-methylstyrene in the air caused kidney tumors, and possibly mononuclear cell leukemia, in male rats. We conclude that a-methylstyrene caused liver cancer in female mice, and also possibly in male mice.
JF  - Technical Report Series. National Toxicology Program
AU  - Anonymous
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 1
EP  - 210
CY  - Research Triangle Park
PB  - U.S. Public Health Service, National Toxicology Program
KW  - Environmental Studies
KW  - Air Pollutants, Occupational
KW  - Carcinogens
KW  - Mutagens
KW  - Styrenes
KW  - alpha-methylstyrol
KW  - Toxicology
KW  - Leukemia
KW  - Rodents
KW  - Kidney Neoplasms -- pathology
KW  - Animals
KW  - Kidney Neoplasms -- chemically induced
KW  - DNA Damage
KW  - Nose Diseases -- chemically induced
KW  - Mutagens -- administration & dosage
KW  - Neoplasms, Experimental -- pathology
KW  - Rats
KW  - Rats, Inbred F344
KW  - Liver Neoplasms -- pathology
KW  - Styrenes -- administration & dosage
KW  - CHO Cells
KW  - Leukemia, Myeloid -- pathology
KW  - Male
KW  - Kidney -- pathology
KW  - Cricetulus
KW  - Micronuclei, Chromosome-Defective -- chemically induced
KW  - Kidney -- drug effects
KW  - Liver Neoplasms -- chemically induced
KW  - Mice
KW  - Leukemia, Myeloid -- chemically induced
KW  - Mice, Inbred Strains
KW  - Inhalation Exposure
KW  - Body Weight -- drug effects
KW  - Female
KW  - Cricetinae
KW  - Neoplasms, Experimental -- etiology
KW  - Toxicity Tests
KW  - Carcinogens -- toxicity
KW  - Mutagens -- toxicity
KW  - Air Pollutants, Occupational -- toxicity
KW  - Styrenes -- toxicity
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LA  - English
DB  - ProQuest Central; ProQuest Environmental Science Collection
N1  - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2007
N1  - Document feature - Tables; Graphs; Photographs; References
N1  - Last updated - 2015-03-22
ER  - 



TY  - RPRT
T1  - FOREWORD
AN  - 236491904
AB  - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public.
JF  - Technical Report Series. National Toxicology Program
AU  - Anonymous
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 1
CY  - Research Triangle Park
PB  - U.S. Public Health Service, National Toxicology Program
KW  - Environmental Studies
KW  - Environmental health
KW  - Public health
KW  - Laboratory animals
KW  - Human exposure
KW  - Health services
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LA  - English
DB  - ProQuest Central; ProQuest Environmental Science Collection
N1  - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2007
N1  - Last updated - 2015-03-22
ER  - 



TY  - RPRT
T1  - Table of contents
AN  - 236445513
JF  - Technical Report Series. National Toxicology Program
AU  - Anonymous
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 4
CY  - Research Triangle Park
PB  - U.S. Public Health Service, National Toxicology Program
KW  - Environmental Studies
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LA  - English
DB  - ProQuest Central; ProQuest Environmental Science Collection
N1  - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2007
N1  - Last updated - 2015-03-22
ER  - 



TY  - JOUR
T1  - Two Domains of Cytotoxic Necrotizing Factor Type 1 Bind the Cellular Receptor, Laminin Receptor Precursor Protein
AN  - 21008620; 7931944
AB  - Cytotoxic necrotizing factor type 1 (CNF1) and CNF2 are highly homologous toxins that are produced by certain pathogenic strains of Escherichia coli. These 1,014-amino-acid toxins catalyze the deamidation of a specific glutamine residue in RhoA, Rac1, and Cdc42 and consist of a putative N-terminal binding domain, a transmembrane region, and a C-terminal catalytic domain. To define the regions of CNF1 that are responsible for binding of the toxin to its cellular receptor, the laminin receptor precursor protein (LRP), a series of CNF1 truncated toxins were characterized and assessed for toxin binding. In particular, three truncated toxins, Delta N63, Delta N545, and Delta C469, retained conformational integrity and in vitro enzymatic activity and were immunologically reactive against a panel of anti-CNF1 monoclonal antibodies (MAbs). Based on a comparison of these truncated toxins with wild-type CNF1 and CNF2 in LRP and HEp-2 cell binding assays and in MAb and LRP competitive binding inhibition assays and based on the results of confocal microscopy, we concluded that CNF1 contains two major binding regions: one located within the N terminus, which contained amino acids 135 to 164, and one which resided in the C terminus and included amino acids 683 to 730. The data further indicate that CNF1 can bind to an additional receptor(s) on HEp-2 cells and that LRP can also serve as a cellular receptor for CNF2.
JF  - Infection and Immunity
AU  - McNichol, Beth A
AU  - Rasmussen, Susan B
AU  - Carvalho, Humberto M
AU  - Meysick, Karen C
AU  - O'Brien, Alison D
AD  - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. FDA/CBER, Bethesda, Maryland 20892
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 5095
EP  - 5104
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 75
IS  - 11
SN  - 0019-9567, 0019-9567
KW  - Immunology Abstracts; Microbiology Abstracts B: Bacteriology
KW  - Glutamine
KW  - Amino acids
KW  - Data processing
KW  - Monoclonal antibodies
KW  - Rac1 protein
KW  - Cdc42 protein
KW  - laminin receptors
KW  - Toxins
KW  - RhoA protein
KW  - Cytotoxic necrotizing factor
KW  - Confocal microscopy
KW  - Escherichia coli
KW  - Enzymatic activity
KW  - J 02350:Immunology
KW  - F 06910:Microorganisms & Parasites
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Glutamine; Data processing; Amino acids; Monoclonal antibodies; Rac1 protein; Cytotoxic necrotizing factor; Confocal microscopy; Cdc42 protein; Enzymatic activity; laminin receptors; Toxins; RhoA protein; Escherichia coli
ER  - 



TY  - JOUR
T1  - Levels of retinyl palmitate and retinol in the skin of SKH-1 mice topically treated with retinyl palmitate and concomitant exposure to simulated solar light for thirteen weeks
AN  - 20891036; 8398077
AB  - Retinyl esters account for more than 70% of the endogenous vitamin A found in human skin, and retinyl palmitate is one of the retinyl esters in this pool. Human skin is also exposed to retinyl palmitate exogenously through the topical application of cosmetic and skin care products that contain retinyl palmitate. To date, there is limited information on the penetration and distribution of retinyl palmitate and vitamin A within in the skin. In this study, the accumulation of retinyl palmitate and generation of retinol in the skin of male and female SKH-1 mice that received repeated topical applications of creams containing 0.0%, 0.1%, 0.5%, 1.0%, 5.0%, 10%, or 13% of retinyl palmitate 5 days a week for a period of 13 weeks were studied. Because products containing retinyl palmitate are frequently applied to sun-exposed skin, and because it is well established that exposure to sunlight and UV light can alter cutaneous levels of retinoids, mice in this study were additionally exposed 5 days a week to simulated solar light. The results showed that retinyl palmitate diffused into the skin and was partially hydrolyzed to retinol. The levels of retinyl palmitate in the skin of mice that were administered retinyl palmitate cream were higher than control values, and levels of both retinyl palmitate and retinol increased with the application of higher concentrations of retinyl palmitate in the cream. Our results indicate that topically applied retinyl palmitate may alter the normal physiological levels of retinyl palmitate and retinol in the skin of SKH-1 mice and may have a significant impact on vitamin A homeostasis in the skin.
JF  - Toxicology and Industrial Health
AU  - Yan, J
AU  - Xia, Q
AU  - Warner, W G
AU  - Boudreau, MD
AU  - Warbritton, A
AU  - Howard, P C
AU  - Fu, P P
AD  - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA, peterfu@fda.hhs.gov
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 581
EP  - 589
VL  - 23
IS  - 10
SN  - 0748-2337, 0748-2337
KW  - Toxicology Abstracts
KW  - Skin
KW  - Cosmetics
KW  - Homeostasis
KW  - Esters
KW  - Light effects
KW  - Topical application
KW  - U.V. radiation
KW  - Palmitic acid
KW  - Vitamin A
KW  - Cream
KW  - Sunlight
KW  - Retinoids
KW  - X 24340:Cosmetics, Toiletries & Household Products
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Levels+of+retinyl+palmitate+and+retinol+in+the+skin+of+SKH-1+mice+topically+treated+with+retinyl+palmitate+and+concomitant+exposure+to+simulated+solar+light+for+thirteen+weeks&rft.au=Yan%2C+J%3BXia%2C+Q%3BWarner%2C+W+G%3BBoudreau%2C+MD%3BWarbritton%2C+A%3BHoward%2C+P+C%3BFu%2C+P+P&rft.aulast=Yan&rft.aufirst=J&rft.date=2007-11-01&rft.volume=23&rft.issue=10&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233708090904
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-08-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - U.V. radiation; Skin; Vitamin A; Palmitic acid; Cream; Sunlight; Cosmetics; Homeostasis; Retinoids; Esters; Topical application; Light effects
DO  - http://dx.doi.org/10.1177/0748233708090904
ER  - 



TY  - JOUR
T1  - UVA photoirradiation of anhydroretinol - formation of singlet oxygen and superoxide
AN  - 20889850; 8398082
AB  - Anhydroretinol is a metabolite of vitamin A (retinol) and a major photodecomposition product of retinyl palmitate and retinyl acetate. Anhydroretinol is biologically active, inducing cell death in lymphoblastoid cells, prevention of N-methyl-N-nitrosourea-induced mammary cancer, and inhibition of cell growth in lymphocytes. We have previously determined that photoirradiation of anhydroretinol in the presence of a lipid, methyl linoleate, with UVA light-induced lipid peroxidation. In the present study, electron spin resonance (ESR) spin-trap techniques were employed to explore the mechanism of lipid peroxidation initiation. Irradiation of anhydroretinol by UVA in the presence of 2,2,6,6-tetramethylpiperidine (TEMP), a specific probe for singlet oxygen, resulted in the formation of TEMPO, indicating that singlet oxygen was generated. During photoirradiation in the presence of 5,5-dimethyl N-oxide pyrroline (DMPO), a specific probe for superoxide, ESR signals for DMPO-OOH were formed, and these signals were quenched by superoxide dismutase. The involvement of singlet oxygen on the induction of lipid peroxidation was also evidenced by the observation that lipid peroxidation was inhibited by sodium azide and enhanced by deuterium oxide. Our overall results provide evidence that photoirradiation of anhydroretinol with UVA light generates reactive oxygen species, e.g. singlet oxygen and superoxide, which mediate the induction of lipid peroxidation.
JF  - Toxicology and Industrial Health
AU  - Yin, J J
AU  - Xia, Q
AU  - Fu, P P
AD  - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA, junjie.yin@fda.hhs.gov
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 625
EP  - 631
VL  - 23
IS  - 10
SN  - 0748-2337, 0748-2337
KW  - Toxicology Abstracts
KW  - Sodium azide
KW  - N-Oxides
KW  - Probes
KW  - Metabolites
KW  - Lymphocytes
KW  - Acetic acid
KW  - Cancer
KW  - Lipid peroxidation
KW  - Light effects
KW  - Cell death
KW  - U.V. radiation
KW  - Reactive oxygen species
KW  - Radiation
KW  - Superoxide dismutase
KW  - Palmitic acid
KW  - Vitamin A
KW  - oxides
KW  - X 24390:Radioactive Materials
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-08-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Sodium azide; Probes; N-Oxides; Metabolites; Lymphocytes; Acetic acid; Lipid peroxidation; Cancer; Light effects; Cell death; U.V. radiation; Radiation; Reactive oxygen species; Superoxide dismutase; Vitamin A; Palmitic acid; oxides
DO  - http://dx.doi.org/10.1177/0748233708090909
ER  - 



TY  - JOUR
T1  - The NIOSH Total Inward Leakage Project
AN  - 20883452; 8416021
AB  - The National Institute for Occupational Safety and Health (NIOSH) conducts a range of efforts in the areas of research, information, and service. The NIOSH program portfolio focuses on relevance, quality, and impact. This is achieved through strong involvement of partners and stakeholders through the entire research continuum (conceiving, planning, conducting, translating, disseminating, and evaluating). The programmatic and support structures provide a foundation for staff to carry out its mission to provide national and world leadership to prevent work-related illnesses and injuries.
JF  - Occupational Health & Safety
AU  - Ann, R B
AD  - National Institute for Occupational Safety and Health's National Personal Protective Technology Laboratory, West Virginia University, USA
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 34
EP  - 38
VL  - 76
IS  - 11
SN  - 0362-4064, 0362-4064
KW  - Health & Safety Science Abstracts
KW  - Leakage
KW  - Injuries
KW  - Occupational safety
KW  - foundations
KW  - portfolios
KW  - stakeholders
KW  - H 1000:Occupational Safety and Health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20883452?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+Health+%26+Safety&rft.atitle=The+NIOSH+Total+Inward+Leakage+Project&rft.au=Ann%2C+R+B&rft.aulast=Ann&rft.aufirst=R&rft.date=2007-11-01&rft.volume=76&rft.issue=11&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Occupational+Health+%26+Safety&rft.issn=03624064&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-09-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - stakeholders; Leakage; Occupational safety; Injuries; foundations; portfolios
ER  - 



TY  - JOUR
T1  - Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease
AN  - 20704872; 7630838
AB  - Bacterial super-infection of influenza patients is the primary cause of excess mortality during influenza pandemics, with Staphylococcus aureus (S. aureus) having the highest fatality rate. The cotton rat (Sigmodon hispidus) is an excellent model for both influenza and S. aureus pathogenesis, and therefore a potential tool to model co-infection. We compared physiologic and pathologic changes in cotton rats infected with both S. aureus and influenza A/Wuhan/359 /95 (H3N2), with animals infected with each pathogen alone. Co-infected cotton rats demonstrated significantly higher mortality, lower temperatures on 2 and 3 days post-inoculation (p.i.), higher levels of bacteremia and pulmonary bacterial load 4 days p.i., and worse pathology 7 days p.i. Early indicators of exacerbated disease coincided with higher pulmonary mRNA levels for IL-1 beta , IL-6, IL-10 and IFNy, supporting the idea that these may contribute to disease severity. Our results demonstrate that the cotton rat is a good model of influenza and S. aureus co-infection, with increased mortality and hypothermia as well as prolonged bacterial duration indicative of synergistic disease that may be the result of increased induction of both pro- and anti-inflammatory cytokines.
JF  - Microbial Pathogenesis
AU  - Braun, LE
AU  - Sutter, DE
AU  - Eichelberger, M C
AU  - Pletneva, L
AU  - Kokai-Kun, J F
AU  - Blanco, JCG
AU  - Prince, G A
AU  - Ottolini, M G
AD  - Inc., Rockville, MD 20850, USA, Maryna.Eichelberger@fda.hhs.gov
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 208
EP  - 216
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 43
IS  - 5-6
SN  - 0882-4010, 0882-4010
KW  - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology
KW  - Temperature effects
KW  - Interleukin 6
KW  - Hypothermia
KW  - Mortality
KW  - Influenza A
KW  - Interleukin 1
KW  - Animal models
KW  - Sigmodon hispidus
KW  - Bacteremia
KW  - Pathogens
KW  - Superinfection
KW  - Interleukin 10
KW  - mRNA
KW  - Inflammation
KW  - pandemics
KW  - Lung
KW  - Influenza A virus
KW  - Cytokines
KW  - Staphylococcus aureus
KW  - J 02410:Animal Diseases
KW  - V 22410:Animal Diseases
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20704872?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Co-infection+of+the+cotton+rat+%28Sigmodon+hispidus%29+with+Staphylococcus+aureus+and+influenza+A+virus+results+in+synergistic+disease&rft.au=Braun%2C+LE%3BSutter%2C+DE%3BEichelberger%2C+M+C%3BPletneva%2C+L%3BKokai-Kun%2C+J+F%3BBlanco%2C+JCG%3BPrince%2C+G+A%3BOttolini%2C+M+G&rft.aulast=Braun&rft.aufirst=LE&rft.date=2007-11-01&rft.volume=43&rft.issue=5-6&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2007.03.005
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Interleukin 6; Temperature effects; Mortality; Hypothermia; Influenza A; Interleukin 1; Animal models; Bacteremia; Pathogens; Superinfection; Interleukin 10; Inflammation; mRNA; pandemics; Lung; Cytokines; Influenza A virus; Sigmodon hispidus; Staphylococcus aureus
DO  - http://dx.doi.org/10.1016/j.micpath.2007.03.005
ER  - 



TY  - JOUR
T1  - Comparison of Direct Genome Restriction Enzyme Analysis and Pulsed-Field Gel Electrophoresis for Typing of Vibrio vulnificus and Their Correspondence with Multilocus Sequence Typing Data
AN  - 20551099; 7928240
AB  - We compared the potential of direct genome restriction enzyme analysis (DGREA) and pulsed-field gel electrophoresis (PFGE) for discriminating Vibrio vulnificus isolates from clinical (23) and environmental (17) sources. The genotypes generated by both methodologies were compared to previous multilocus sequence typing (MLST) data. DGREA established clearer relationships among V. vulnificus strains and was more consistent with MLST than with PFGE. DGREA is a very promising tool for epidemiological and ecological studies of V. vulnificus.
JF  - Applied and Environmental Microbiology
AU  - Gonzalez-Escalona, Narjol
AU  - Whitney, Brooke
AU  - Jaykus, Lee-Ann
AU  - DePaola, Angelo
AD  - Department of Food Science, North Carolina State University, Raleigh, North Carolina. FDA Gulf Coast Seafood Laboratory, Dauphin Island, Alabama
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 7494
EP  - 7500
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 73
IS  - 22
SN  - 0099-2240, 0099-2240
KW  - Genetics Abstracts; Microbiology Abstracts B: Bacteriology
KW  - Genomes
KW  - Vibrio vulnificus
KW  - Pulsed-field gel electrophoresis
KW  - Enzymes
KW  - Genotypes
KW  - multilocus sequence typing
KW  - J 02310:Genetics & Taxonomy
KW  - G 07770:Bacteria
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20551099?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Comparison+of+Direct+Genome+Restriction+Enzyme+Analysis+and+Pulsed-Field+Gel+Electrophoresis+for+Typing+of+Vibrio+vulnificus+and+Their+Correspondence+with+Multilocus+Sequence+Typing+Data&rft.au=Gonzalez-Escalona%2C+Narjol%3BWhitney%2C+Brooke%3BJaykus%2C+Lee-Ann%3BDePaola%2C+Angelo&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2007-11-01&rft.volume=73&rft.issue=22&rft.spage=7494&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-02-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Genomes; Pulsed-field gel electrophoresis; Enzymes; Genotypes; multilocus sequence typing; Vibrio vulnificus
ER  - 



TY  - JOUR
T1  - A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis
AN  - 20527752; 7745882
AB  - Conventional diagnostic tests for tuberculosis have several limitations and are often unhelpful in establishing the diagnosis of extrapulmonary tuberculosis. Although commercial serological antibody based tests are available, their usefulness in the diagnosis of extrapulmonary tuberculosis is unknown. A systematic review was conducted to assess the accuracy of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis. In a comprehensive search, 21 studies that reported data on sensitivity and specificity for extrapulmonary tuberculosis were identified. These studies evaluated seven different commercial tests, with Anda-TB IgG accounting for 48% of the studies. The results showed that (1) all commercial tests provided highly variable estimates of sensitivity (range 0.00-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (2) the Anda-TB IgG kit showed highly variable sensitivity (range 0.26-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (3) for all tests combined, sensitivity estimates for both lymph node tuberculosis (range 0.23-1.00) and pleural tuberculosis (range 0.26-0.59) were poor and inconsistent; and (4) there were no data to determine the accuracy of the tests in children or in patients with HIV infection, the two groups for which the test would be most useful. At present, commercial antibody detection tests for extrapulmonary tuberculosis have no role in clinical care or case detection.
JF  - Postgraduate Medical Journal
AU  - Steingart, Karen R
AU  - Henry, Megan
AU  - Laal, Suman
AU  - Hopewell, Philip C
AU  - Ramsay, Andrew
AU  - Menzies, Dick
AU  - Cunningham, Jane
AU  - Weldingh, Karin
AU  - Pai, Madhukar
AD  - Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, and Francis J Curry National Tuberculosis Center, San Francisco, California, USA County of Sacramento Department of Health and Human Services, Sacramento, California, USA Veterans Affairs Medical Center and Departments of Pathology and Microbiology, New York University School of Medicine, New York, USA UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen S, Denmark
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 705
EP  - 712
PB  - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/]
VL  - 83
IS  - 985
SN  - 0032-5473, 0032-5473
KW  - Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW  - Human immunodeficiency virus
KW  - Immunoglobulin G
KW  - Tuberculosis
KW  - Infection
KW  - Children
KW  - Lymph nodes
KW  - J 02310:Genetics & Taxonomy
KW  - F 06910:Microorganisms & Parasites
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20527752?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+Medical+Journal&rft.atitle=A+systematic+review+of+commercial+serological+antibody+detection+tests+for+the+diagnosis+of+extrapulmonary+tuberculosis&rft.au=Steingart%2C+Karen+R%3BHenry%2C+Megan%3BLaal%2C+Suman%3BHopewell%2C+Philip+C%3BRamsay%2C+Andrew%3BMenzies%2C+Dick%3BCunningham%2C+Jane%3BWeldingh%2C+Karin%3BPai%2C+Madhukar&rft.aulast=Steingart&rft.aufirst=Karen&rft.date=2007-11-01&rft.volume=83&rft.issue=985&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Postgraduate+Medical+Journal&rft.issn=00325473&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Immunoglobulin G; Tuberculosis; Children; Infection; Lymph nodes; Human immunodeficiency virus
ER  - 



TY  - JOUR
T1  - Effects on Outpatient and Emergency Mental Health Care of Strict Medicaid Early Periodic Screening, Diagnosis, and Treatment Enforcement
AN  - 20521864; 7928520
AB  - We investigated enforcement of mental health benefits provided by California Medicaid's Early Periodic Screening, Diagnosis, and Treatment (EPSDT) program. Enforcement, compelled by a consumer-driven lawsuit, resulted in an almost 4-fold funding increase over a 5-year period. We evaluated the impact of enforcement on outpatient treatment intensity (number of visits per child) and rates of emergency care treatment. Using fixed-effects regression, we examined the number of outpatient mental health visits per client and the percentage of all clients using crisis care across 53 autonomous California county mental health plans over 32 three-month periods (quarters; emergency crisis care rates) and 36 quarters (out-patient mental health visits). Enforcement of EPSDT benefits in accordance with federal law produced favorable changes in patterns of mental health service use, consistent with policy aims.
JF  - American Journal of Public Health
AU  - Snowden, Lonnie R
AU  - Masland, Mary C
AU  - Wallace, Neal T
AU  - Evans-Cuellar, Allison
AD  - Lonnie R. Snowden is with the School of Social Welfare and the Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, Berkeley. Mary C. Masland is with the Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, Berkeley. Neal T. Wallace is with the Division of Public Administration, Mark O. Hatfield School of Government, Portland State University, Portland, Ore. Allison Evans-Cuellar is with the Department of Health Policy and Management, Joseph P. Mailman School of Public Health, Columbia University, New York, NY
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 1951
EP  - 1956
PB  - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA
VL  - 97
IS  - 11
SN  - 0090-0036, 0090-0036
KW  - Sustainability Science Abstracts
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20521864?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Effects+on+Outpatient+and+Emergency+Mental+Health+Care+of+Strict+Medicaid+Early+Periodic+Screening%2C+Diagnosis%2C+and+Treatment+Enforcement&rft.au=Snowden%2C+Lonnie+R%3BMasland%2C+Mary+C%3BWallace%2C+Neal+T%3BEvans-Cuellar%2C+Allison&rft.aulast=Snowden&rft.aufirst=Lonnie&rft.date=2007-11-01&rft.volume=97&rft.issue=11&rft.spage=1951&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2011-12-13
ER  - 



TY  - JOUR
T1  - Improved BLAST searches using longer words for protein seeding
AN  - 20498081; 7929366
AB  - MOTIVATION: The blastp and tblastn modules of BLAST are widely used methods for searching protein queries against protein and nucleotide databases, respectively. One heuristic used in BLAST is to consider only database sequences that contain a high-scoring match of length at most 5 to the query. We implemented the capability to use words of length 6 or 7. We demonstrate an improved trade-off between running time and retrieval accuracy, controlled by the score threshold used for short word matches. For example, the running time can be reduced by 20-30% while achieving ROC (receiver operator characteristic) scores similar to those obtained with current default parameters. AVAILABILITY: The option to use long words is in the NCBI C and C++ toolkit code for BLAST, starting with version 2.2.16 of blastall. A Linux executable used to produce the results herein is available at: ftp://ftp.ncbi.nlm.nih.gov/pub/agarwala/protein_longwords.
JF  - Bioinformatics
AU  - Shiryev, Sergey A
AU  - Papadopoulos, Jason S
AU  - Schaeffer, Alejandro A
AU  - Agarwala, Richa
AD  - Department of Health and Human Services, National Center for Biotechnology Information, National Institutes of Health, richa@helix.nih.gov
Y1  - 2007/11/01/
PY  - 2007
DA  - 2007 Nov 01
SP  - 2949
EP  - 2951
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples[at]oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 23
IS  - 21
SN  - 1367-4803, 1367-4803
KW  - Biotechnology and Bioengineering Abstracts
KW  - Databases
KW  - Seeding
KW  - Problem solving
KW  - Bioinformatics
KW  - Nucleotides
KW  - W 30960:Bioinformatics & Computer Applications
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20498081?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Improved+BLAST+searches+using+longer+words+for+protein+seeding&rft.au=Shiryev%2C+Sergey+A%3BPapadopoulos%2C+Jason+S%3BSchaeffer%2C+Alejandro+A%3BAgarwala%2C+Richa&rft.aulast=Shiryev&rft.aufirst=Sergey&rft.date=2007-11-01&rft.volume=23&rft.issue=21&rft.spage=2949&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Databases; Problem solving; Seeding; Bioinformatics; Nucleotides
ER  - 



TY  - JOUR
T1  - Quantitative measurement of cyanide released from Prussian Blue
AN  - 20437617; 7828214
AB  - Background. Prussian Blue (PB), ferric hexacyanoferrate is indicated for (oral) treatment of internal contamination with radioisotopes of cesium or thallium. Cyanide is 35-40% of PB's molecular composition, thus cyanide may be released during transit through the digestive tract under physiological pH. The U.S. Food and Drug Administration investigated the issue of cyanide release prior to drug approval to ensure the drug's benefits exceeded risks. Objectives. To determine cyanide released from PB under pH conditions that bracket human physiological exposure. Methods. PB was incubated in situ at pH 1.0-12, 37 degree C for 1-48 hours. Cyanide was measured using a validated colorimetric method by UV-VIS spectroscopy. Results. PB had the highest cyanide release at pH 1 (135 ug/g) and lowest release at pH 5.0-7.0 from the highest daily dose of PB (17.5 g) (21 ug/g). Considering the minimal lethal dose of cyanide is approximately 50 mg, the maximal cyanide released (1.6 mg) does not present a safety concern.
JF  - Clinical Toxicology
AU  - Yang, Y
AU  - Brownell, C
AU  - Sadrieh, N
AU  - May, J
AU  - Del Grosso, A
AU  - Place, D
AU  - Leutzinger, E
AU  - Duffy, E
AU  - He, R
AU  - Houn, F
AU  - Lyon, R
AU  - Faustino, P
AD  - Division of Product Quality Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Life Science Building-64, Room 1078, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA, patrick.faustino@fda.hhs.gov
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 776
EP  - 781
VL  - 45
IS  - 7
SN  - 1556-3650, 1556-3650
KW  - Toxicology Abstracts
KW  - Drug delivery
KW  - Cesium
KW  - Colorimetry
KW  - Spectroscopy
KW  - Food contamination
KW  - Lead
KW  - Cyanide
KW  - Digestive tract
KW  - Radioisotopes
KW  - Thallium
KW  - pH effects
KW  - Lethal dose
KW  - X 24360:Metals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20437617?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Toxicology&rft.atitle=Quantitative+measurement+of+cyanide+released+from+Prussian+Blue&rft.au=Yang%2C+Y%3BBrownell%2C+C%3BSadrieh%2C+N%3BMay%2C+J%3BDel+Grosso%2C+A%3BPlace%2C+D%3BLeutzinger%2C+E%3BDuffy%2C+E%3BHe%2C+R%3BHoun%2C+F%3BLyon%2C+R%3BFaustino%2C+P&rft.aulast=Yang&rft.aufirst=Y&rft.date=2007-11-01&rft.volume=45&rft.issue=7&rft.spage=776&rft.isbn=&rft.btitle=&rft.title=Clinical+Toxicology&rft.issn=15563650&rft_id=info:doi/10.1080%2F15563650601181562
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Drug delivery; Cesium; Digestive tract; Cyanide; Radioisotopes; Colorimetry; Thallium; Food contamination; Spectroscopy; pH effects; Lead; Lethal dose
DO  - http://dx.doi.org/10.1080/15563650601181562
ER  - 



TY  - JOUR
T1  - Spatial and temporal patterns of alkaloid variation in the poison frog Oophaga pumilio in Costa Rica and Panama over 30 years
AN  - 20410406; 7637489
AB  - A total of 232 alkaloids, representing 21 structural classes were detected in skin extracts from the dendrobatid poison frog Oophaga pumilio, collected from 53 different populations from over 30 years of research. The highly toxic pumiliotoxins and allopumiliotoxins, along with 5,8-disubstitiuted and 5,6,8-trisubstituted indolizidines, all of which are proposed to be of dietary mite origin, were common constituents in most extracts. One decahydroquinoline (DHQ), previously shown be of ant origin, occurred in many extracts often as a major alkaloid, while other DHQs occurred rather infrequently. Histrionicotoxins, thought to be of ant origin, did not appear to possess a specific pattern of occurrence among the populations, but when present, were usually found as major components. Certain 3,5-disubstituted pyrrolizidines and indolizidines, known to be of ant origin, did occur in extracts, but infrequently. Alkaloid composition differed with regard to geographic location of frog populations, and for populations that were sampled two or more times during the 30-year period significant changes in alkaloid profiles sometimes occurred. The results of this study indicate that chemical defense in a dendrobatid poison frog is dependent on geographic location and habitat type, which presumably controls the abundance and nature of alkaloid-containing arthropods.
JF  - Toxicon
AU  - Saporito, R A
AU  - Donnelly, MA
AU  - Jain, P
AU  - Martin Garraffo, H
AU  - Spande, T F
AU  - Daly, J W
AD  - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA, jdaly@nih.gov
Y1  - 2007/11//
PY  - 2007
DA  - November 2007
SP  - 757
EP  - 778
PB  - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl]
VL  - 50
IS  - 6
SN  - 0041-0101, 0041-0101
KW  - Ants
KW  - ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts
KW  - Panama
KW  - Geographical distribution
KW  - Skin
KW  - Amphibiotic species
KW  - Biochemistry
KW  - Biological poisons
KW  - Costa Rica
KW  - Abundance
KW  - Anura
KW  - Formicidae
KW  - Animal physiology
KW  - Freshwater
KW  - Habitat
KW  - Alkaloids
KW  - Arthropoda
KW  - Oophaga pumilio
KW  - X 24370:Natural Toxins
KW  - Q1 08326:Physiology, biochemistry, biophysics
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20410406?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Spatial+and+temporal+patterns+of+alkaloid+variation+in+the+poison+frog+Oophaga+pumilio+in+Costa+Rica+and+Panama+over+30+years&rft.au=Saporito%2C+R+A%3BDonnelly%2C+MA%3BJain%2C+P%3BMartin+Garraffo%2C+H%3BSpande%2C+T+F%3BDaly%2C+J+W&rft.aulast=Saporito&rft.aufirst=R&rft.date=2007-11-01&rft.volume=50&rft.issue=6&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2007.06.022
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2016-05-27
N1  - SubjectsTermNotLitGenreText - Geographical distribution; Alkaloids; Biochemistry; Amphibiotic species; Biological poisons; Animal physiology; Skin; Abundance; Habitat; Arthropoda; Oophaga pumilio; Formicidae; Anura; Panama; Costa Rica; Freshwater
DO  - http://dx.doi.org/10.1016/j.toxicon.2007.06.022
ER  - 



TY  - JOUR
T1  - Diffuse-interface theory for structure formation and release behavior in controlled drug release systems
AN  - 20339270; 7637284
AB  - A common method of controlling drug release has been to incorporate the drug into a polymer matrix, thereby creating a diffusion barrier that slows the rate of drug release. It has been demonstrated that the internal microstructure of these drug-polymer composites can significantly impact the drug release rate. However, the effect of processing conditions during manufacture on the composite structure and the subsequent effects on release behavior are not well understood. We have developed a diffuse-interface theory for microstructure evolution that is based on interactions between drug, polymer and solvent species, all of which may be present in either crystalline or amorphous states. Because the theory can be applied to almost any specific combination of material species and over a wide range of environmental conditions, it can be used to elucidate and quantify the relationships between processing, microstructure and release response in controlled drug release systems. Calculations based on the theory have now demonstrated that, for a characteristic delivery system, variations in microstructure arising due to changes in either drug loading or processing time, i.e. evaporation rate, could have a significant impact on both the bulk release kinetics and the uniformity of release across the system. In fact, we observed that changes in process time alone can induce differences in bulk release of almost a factor of two and typical non-uniformities of +/-30% during the initial periods of release. Because these substantial variations may have deleterious clinical ramifications, it is critical that both the system microstructure and the control of that microstructure are considered to ensure the device will be both safe and effective in clinical use.
JF  - Acta Biomaterialia
AU  - Saylor, D M
AU  - Kim, C S
AU  - Patwardhan, D V
AU  - Warren, JA
AD  - Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Silver Spring, MD 20903, USA, david.saylor@fda.hhs.gov
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 851
EP  - 864
PB  - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl]
VL  - 3
IS  - 6
SN  - 1742-7061, 1742-7061
KW  - Biotechnology and Bioengineering Abstracts
KW  - Drug delivery
KW  - Evaporation
KW  - Kinetics
KW  - Solvents
KW  - Diffusion
KW  - Environmental conditions
KW  - W 30915:Pharmaceuticals & Vaccines
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20339270?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Biomaterialia&rft.atitle=Diffuse-interface+theory+for+structure+formation+and+release+behavior+in+controlled+drug+release+systems&rft.au=Saylor%2C+D+M%3BKim%2C+C+S%3BPatwardhan%2C+D+V%3BWarren%2C+JA&rft.aulast=Saylor&rft.aufirst=D&rft.date=2007-11-01&rft.volume=3&rft.issue=6&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Acta+Biomaterialia&rft.issn=17427061&rft_id=info:doi/10.1016%2Fj.actbio.2007.03.011
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2011-12-13
N1  - SubjectsTermNotLitGenreText - Drug delivery; Environmental conditions; Kinetics; Evaporation; Solvents; Diffusion
DO  - http://dx.doi.org/10.1016/j.actbio.2007.03.011
ER  - 



TY  - JOUR
T1  - Mammalian Iron Metabolism
AN  - 20253887; 8883035
AB  - Iron is an essential transition metal for mammalian cellular and tissue viability. It is critical to supplying oxygen through heme, the mitochondrial respiratory chain, and enzymes such as ribonucleotide reductase. Mammalian organisms have evolved with the means of regulating the metabolism of iron, because if left unregulated, the resulting excess amounts of iron may induce chronic toxicities affecting multiple organ systems. Several homeostatic mechanisms exist to control the amount of intestinal dietary iron uptake, cellular iron uptake, distribution, and export. Within these processes, numerous molecular participants have been identified because of advancements in basic cell biology and efforts in disease-based research of iron storage abnormalities. For example, dietary iron uptake across the intestinal duodenal mucosa is mediated by an intramembrane divalent metal transporter 1 (DMT1), and cellular iron efflux involves ferroportin, the only known iron exporter. In addition to duodenal enterocytes, ferroportin is present in other cell types, and exports iron into plasma. Ferroportin was recently discovered to be regulated by the expression of the circulating hormone hepcidin, a small peptide synthesized in hepatocytes. These recent studies on the role of hepcidin in the regulation of dietary, cellular, and extracellular iron have led to a better understanding of the pathways by which iron balance in humans is influenced, especially its involvement in human genetic diseases of iron overload. Other important molecular pathways include iron binding to transferrin in the bloodstream for cellular delivery through the plasma membrane transferrin receptor (TfR1). In the cytosol, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a prominent role in sensing the presence of iron in order to posttranscriptionally regulate the expression of TfR1 and ferritin, two important participants in iron metabolism. From a toxicological standpoint, posttranscriptional regulation of these genes aids in the sequestration, control, and hence prevention of cytotoxic effects from free-floating nontransferrin-bound iron. Given the importance of dietary iron in normal physiology, its potential to induce chronic toxicity, and recent discoveries in the regulation of human iron metabolism by hepcidin, this review will address the regulatory mechanisms of normal iron metabolism in mammals with emphasis on dietary exposure. It is the goal of this review that this information may provide in a concise format our current understanding of major pathways and mechanisms involved in mammalian iron metabolism, which is a basis for control of iron toxicity. Such a discussion is intended to facilitate the identification of deficiencies so that future metabolic or toxicological studies may be appropriately focused. A better knowledge of iron metabolism from normal to pathophysiological conditions will ultimately broaden the spectrum of the usefulness of this information in biomedical and toxicological sciences for improving and protecting human health.
JF  - Toxicology Mechanisms and Methods
AU  - Valerio Jr, Luis G
AD  - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition,Office of Food Additive Safety, Division of Biotechnology and GRAS Notice Review, College Park, MD, USA
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 497
EP  - 517
PB  - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk]
VL  - 17
IS  - 9
SN  - 1537-6516, 1537-6516
KW  - Toxicology Abstracts; Genetics Abstracts
KW  - Heme
KW  - Hepatocytes
KW  - Mucosa
KW  - Mitochondria
KW  - Transition metals
KW  - Hormones
KW  - Iron regulatory protein
KW  - Transferrin receptors
KW  - Plasma membranes
KW  - Chronic toxicity
KW  - Hepcidin
KW  - Enterocytes
KW  - Enzymes
KW  - Transcription
KW  - Toxicity
KW  - Oxygen
KW  - Cytotoxicity
KW  - Divalent metal transporter-1
KW  - Transferrin
KW  - Reviews
KW  - Gene regulation
KW  - Intestine
KW  - Cytosol
KW  - Ribonucleoside-triphosphate reductase
KW  - Ferritin
KW  - Post-transcription
KW  - Electron transport
KW  - Iron
KW  - Metabolism
KW  - G 07880:Human Genetics
KW  - X 24360:Metals
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20253887?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=A+comparison+of+the+pulmonary+inflammatory+potential+of+different+components+of+yeast+cell+wall.&rft.au=Young%2C+Shih-Houng%3BOstroff%2C+Gary+R%3BZeidler-Erdely%2C+Patti+C%3BRoberts%2C+Jenny+R%3BAntonini%2C+James+M%3BCastranova%2C+Vincent&rft.aulast=Young&rft.aufirst=Shih-Houng&rft.date=2007-07-01&rft.volume=70&rft.issue=13&rft.spage=1116&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-02-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Heme; Hepatocytes; Mucosa; Mitochondria; Transition metals; Iron regulatory protein; Hormones; Plasma membranes; Transferrin receptors; Chronic toxicity; Hepcidin; Enterocytes; Transcription; Enzymes; Toxicity; Oxygen; Transferrin; Divalent metal transporter-1; Cytotoxicity; Gene regulation; Reviews; Cytosol; Intestine; Ribonucleoside-triphosphate reductase; Ferritin; Electron transport; Post-transcription; Iron; Metabolism
DO  - http://dx.doi.org/10.1080/15376510701556690
ER  - 



TY  - JOUR
T1  - Bacterial endospore inactivation caused by outgassing of vapourous hydrogen peroxide from polymethyl methacrylate (Plexiglas super( registered ))
AN  - 19863317; 7997339
AB  - Aims: To investigate the cause and to eliminate the inactivation of Bacillus anthracis strain Sterne spores settled onto agar and stainless steel surfaces in plastic holders. Methods and Results: In an experimental chamber in which spores settled onto sampling surfaces, vapourous hydrogen peroxide (VHP) was used for decontamination between experiments. It was demonstrated that hydrogen peroxide (H sub(2)O sub(2)) absorbed into plastic (Plexiglas super( registered )) surfaces and could outgas in the sample holders. Further experiments demonstrated that H sub(2)O sub(2) was released from Plexiglas super( registered ) sample holders in sufficient quantity to inactivate spores. High temperature degassing (30-35 degree C) for several days or aluminum coating of the surfaces were two remedies found to be effective in preventing inadvertent spore inactivation. Conclusions: H sub(2)O sub(2) can be absorbed into plastic and released after an extended period of time (weeks), allowing a sufficient concentration to accumulate in small volumes to inactivate spores. Outgassing the plastic or coating the surface with an impermeable layer are potential solutions to reduce spore inactivation. Significance and Impact of the Study: Many studies with bacilli and other organisms are carried out using small plastic containers that may have been sterilized using H sub(2)O sub(2) or other agents. This study presents a cautionary note to ensure elimination of H sub(2)O sub(2) or other sterilizing agents to prevent spurious results.
JF  - Letters in Applied Microbiology
AU  - Baron, P A
AU  - Estill, C F
AU  - Beard, J K
AU  - Hein, MJ
AU  - Larsen, L
AD  - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA, pbaron@cdc.gov
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 485
EP  - 490
PB  - Blackwell Publishing Ltd., 9600 Garsington Road
VL  - 45
IS  - 5
SN  - 0266-8254, 0266-8254
KW  - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - Bacillus anthracis
KW  - decontamination
KW  - hydrogen peroxide
KW  - outgassing
KW  - Plexiglas
KW  - spore
KW  - sterilization
KW  - VHP
KW  - Temperature effects
KW  - Agar
KW  - Bacilli
KW  - Decontamination
KW  - Hydrogen peroxide
KW  - Aluminum
KW  - Plastics
KW  - Sampling
KW  - Spores
KW  - polymethylmethacrylate
KW  - Coatings
KW  - stainless steel
KW  - A 01490:Miscellaneous
KW  - J 02320:Cell Biology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19863317?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Letters+in+Applied+Microbiology&rft.atitle=Bacterial+endospore+inactivation+caused+by+outgassing+of+vapourous+hydrogen+peroxide+from+polymethyl+methacrylate+%28Plexiglas+super%28+registered+%29%29&rft.au=Baron%2C+P+A%3BEstill%2C+C+F%3BBeard%2C+J+K%3BHein%2C+MJ%3BLarsen%2C+L&rft.aulast=Baron&rft.aufirst=P&rft.date=2007-11-01&rft.volume=45&rft.issue=5&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Letters+in+Applied+Microbiology&rft.issn=02668254&rft_id=info:doi/10.1111%2Fj.1472-765X.2007.02209.x
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-02-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Temperature effects; Bacilli; Agar; Hydrogen peroxide; Aluminum; Decontamination; Sampling; Plastics; polymethylmethacrylate; Spores; stainless steel; Coatings; Bacillus anthracis
DO  - http://dx.doi.org/10.1111/j.1472-765X.2007.02209.x
ER  - 



TY  - JOUR
T1  - Annexin A2 is a soluble mediator of macrophage activation
AN  - 19810224; 8124708
AB  - On the surface of the macrophage, annexin A2 tetramer (A2t) serves as a docking protein or recognition element for bacterial and viral pathogens. Plasma levels of free A2t have been reported to increase following infection, although the mechanistic significance of this observation is unclear. Although annexin A2 had generally been thought to play an anti-inflammatory role, soluble A2t stimulates MAP kinase activity in bone marrow stromal cells downstream of a recently cloned receptor. This raises the question of whether A2t activates human macrophages via MAP kinases and whether it might be capable of acting as an inflammatory mediator. To this end, human monocyte-derived macrophages were treated with soluble A2t and MAP kinase phosphorylation, p65 NF- Kappa B activation, and inflammatory mRNA and protein levels were measured. It was found that A2t caused rapid phosphorylation of several MAP kinases, as well as translocation of p65 NF- Kappa B to the nucleus. A2t stimulated the production of TNF- alpha , IL-1 beta , and IL-6, as well as several members of the chemokine family within 24 h, which are capable of recruitment and/or activation of a broad range of leukocyte classes. Furthermore, A2t-activated macrophages demonstrated enhanced phagocytic ability for the ingestion of GFP-expressing Escherichia coli. These data are the first to suggest the participation of an annexin in microbial clearance, as well as the establishment of inflammation and the immune response, including the recruitment and activation of immune cells to the site of infection.
JF  - Journal of Leukocyte Biology
AU  - Swisher, JFA
AU  - Khatri, U
AU  - Feldman, G M
AD  - Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bldg. 29A, Rm. 3C22, 29 Lincoln Dr., HFD-123, Bethesda, MD 20892, USA, gerald.feldman@fda.hhs.gov
Y1  - 2007/11/01/
PY  - 2007
DA  - 2007 Nov 01
SP  - 1174
EP  - 1184
VL  - 82
IS  - 5
SN  - 0741-5400, 0741-5400
KW  - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts
KW  - Macrophages
KW  - Interleukin 6
KW  - Chemokines
KW  - stromal cells
KW  - Interleukin 1
KW  - Bone marrow
KW  - Infection
KW  - NF- Kappa B protein
KW  - Cell activation
KW  - Nuclear transport
KW  - Phosphorylation
KW  - Phagocytes
KW  - Escherichia coli
KW  - Monocytes
KW  - MAP kinase
KW  - Data processing
KW  - Leukocytes
KW  - Pathogens
KW  - Inflammation
KW  - mRNA
KW  - Plasma levels
KW  - Annexins
KW  - Tumor necrosis factor- alpha
KW  - Immune response
KW  - V 22350:Immunology
KW  - J 02350:Immunology
KW  - F 06910:Microorganisms & Parasites
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19810224?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Annexin+A2+is+a+soluble+mediator+of+macrophage+activation&rft.au=Swisher%2C+JFA%3BKhatri%2C+U%3BFeldman%2C+G+M&rft.aulast=Swisher&rft.aufirst=JFA&rft.date=2007-11-01&rft.volume=82&rft.issue=5&rft.spage=1174&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.0307154
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Interleukin 6; Macrophages; Chemokines; MAP kinase; Data processing; stromal cells; Interleukin 1; Leukocytes; Bone marrow; Pathogens; Infection; mRNA; Cell activation; Inflammation; NF- Kappa B protein; Nuclear transport; Plasma levels; Annexins; Phosphorylation; Phagocytes; Monocytes; Immune response; Tumor necrosis factor- alpha; Escherichia coli
DO  - http://dx.doi.org/10.1189/jlb.0307154
ER  - 



TY  - JOUR
T1  - Comparison of Neisseria meningitidis serogroup W135 polysaccharide- tetanus toxoid conjugate vaccines made by periodate activation of O- acetylated, non-O-acetylated and chemically de-O-acetylated polysaccharide
AN  - 19634852; 8767953
AB  - Polysaccharide (PS) and tetanus toxoid (TT) protein conjugate vaccines were prepared using O-acetylated (OAc super(+)), O-acetyl negative (OAc super(-)) and chemically de-O-acetylated (de-OAc) meningococcal W135 PS. The PSs were activated by periodate oxidation and coupled to hydrazine derivatized TT. High performance anion exchange chromatography of acid hydrolysates of periodate activated W135 PSs, showed that galactose residues in OAc super(+) PS were more sensitive to the periodate oxidation step than they were in the OAc super(-) PS or de-OAc PS. Mouse antisera against OAc super(-)-TT conjugate vaccines recognized both OAc super(-) and OAc super(+) PS by ELISAs and had high bactericidal titers against both OAc super(+) and OAc super(-) W135 strains. Purified high molecular weight (HMW) conjugates showed higher PS to protein ratios in OAc super(-)-TT sub((HMW)) and de-OAc-TT sub((HMW)) indicating better conjugation efficiency than OAc super(+)-TT sub((HMW)) conjugate. Antisera against the HMW fractions gave higher bactericidal titers than antisera against unfractionated conjugates. Inhibition ELISAs indicated that OAc super(-) and OAc super(+) HMW conjugates induced antibodies that bound both OAc super(+) and OAc super(-) PS. Thus, for W135, PS O-acetylation does not contribute a dominant immunogenic epitope. The OAc super(-) PS may be a good starting material for preparing W135 PS-TT conjugate vaccines using periodate oxidation.
JF  - Vaccine
AU  - Gudlavalleti, Seshu K
AU  - Lee, Che-Hung
AU  - Norris, Scott E
AU  - Paul-Satyaseela, Maneesh
AU  - Vann, Willie F
AU  - Frasch, Carl E
AD  - Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Bethesda, MD, USA, gudlavalletis@yahoo.com
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 7972
EP  - 7980
PB  - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl]
VL  - 25
IS  - 46
SN  - 0264-410X, 0264-410X
KW  - Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW  - Neisseria meningitidis serogroup W135
KW  - Polysaccharide O-acetylation
KW  - Conjugate vaccines
KW  - Galactose
KW  - Enzyme-linked immunosorbent assay
KW  - Anions
KW  - Hydrazine
KW  - Chromatography
KW  - Neisseria meningitidis
KW  - Polysaccharides
KW  - Tetanus
KW  - Antibodies
KW  - Antisera
KW  - Immunogenicity
KW  - Oxidation
KW  - Vaccines
KW  - Epitopes
KW  - Hydrolysates
KW  - F 06905:Vaccines
KW  - J 02340:Antibiotics & Antimicrobials
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Comparison+of+Neisseria+meningitidis+serogroup+W135+polysaccharide-+tetanus+toxoid+conjugate+vaccines+made+by+periodate+activation+of+O-+acetylated%2C+non-O-acetylated+and+chemically+de-O-acetylated+polysaccharide&rft.au=Gudlavalleti%2C+Seshu+K%3BLee%2C+Che-Hung%3BNorris%2C+Scott+E%3BPaul-Satyaseela%2C+Maneesh%3BVann%2C+Willie+F%3BFrasch%2C+Carl+E&rft.aulast=Gudlavalleti&rft.aufirst=Seshu&rft.date=2007-11-01&rft.volume=25&rft.issue=46&rft.spage=7972&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.06.018
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Galactose; Enzyme-linked immunosorbent assay; Anions; Hydrazine; Chromatography; Tetanus; Polysaccharides; Antisera; Antibodies; Immunogenicity; Oxidation; Vaccines; Hydrolysates; Epitopes; Neisseria meningitidis
DO  - http://dx.doi.org/10.1016/j.vaccine.2007.06.018
ER  - 



TY  - JOUR
T1  - New procedure for assessing sequential manual lifting jobs using the revised NIOSH lifting equation
AN  - 19549034; 8681501
AB  - A sequential manual lifting job is defined as a job where workers rotate between a series of manual lifting rotation slots or elements at specified time intervals during the course of a work shift. The original NIOSH lifting equation lacked a method for assessing the physical demands of these types of jobs. This paper presents the sequential lifting index (SLI), a new conceptual method for assessing the physical demands for sequential manual lifting jobs. The new method is similar to the composite lifting index (CLI) method that was provided by NIOSH for assessing multi-task jobs. The SLI method expands upon the methods originally provided by NIOSH by providing a simple method for estimating the relative magnitude of physical stress for sequential manual lifting jobs. It should also be useful in assisting safety and health specialists to prioritize or rank hazardous jobs within a plant.
JF  - Ergonomics
AU  - Waters, T R
AU  - Lu, M-L
AU  - Occhipinti, E
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 1761
EP  - 1770
PB  - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk]
VL  - 50
IS  - 11
SN  - 0014-0139, 0014-0139
KW  - Health & Safety Science Abstracts
KW  - shift work
KW  - composite materials
KW  - Stress
KW  - working conditions
KW  - lifting
KW  - Ergonomics
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19549034?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=New+procedure+for+assessing+sequential+manual+lifting+jobs+using+the+revised+NIOSH+lifting+equation&rft.au=Waters%2C+T+R%3BLu%2C+M-L%3BOcchipinti%2C+E&rft.aulast=Waters&rft.aufirst=T&rft.date=2007-11-01&rft.volume=50&rft.issue=11&rft.spage=1761&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130701674364
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - lifting; Ergonomics; Stress; working conditions; composite materials; shift work
DO  - http://dx.doi.org/10.1080/00140130701674364
ER  - 



TY  - JOUR
T1  - Race, Occupation, and Lung Cancer: Detecting Disparities With Death Certificate Data
AN  - 19522672; 7768320
AB  - Objectives: To determine whether the analysis of death certificate data would reveal the same relationship among race, occupational exposure, and lung cancer mortality observed by a large cohort study. Methods: An occupation-specific mortality odds ratio (MOR) for lung cancer (ICD-162) versus all other causes was calculated for 218, 341 black men and white men who had been employed in the metal industries. Results: Black men were at increased risk for lung cancer mortality when compared with white men among the 4668 oven workers (MOR = 1.38, 95% CI = 1.10 to 1.73), but not among the 33, 605 white-collar workers (MOR = 0.95, 95% CI = 0.74 to 1.23). Conclusions: Our findings corroborate a previously demonstrated association among exposure to carcinogenic coke oven emissions, race, and lung cancer mortality, and support the use of death certificate data to help identify occupations with racial disparities in lung cancer mortality.
JF  - Journal of Occupational and Environmental Medicine
AU  - Birdsey, J
AU  - Alterman, T
AU  - Petersen, M R
AD  - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R17, Cincinnati, OH 45226, USA, JBirdsey@cdc.gov
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
SP  - 1257
EP  - 1263
VL  - 49
IS  - 11
SN  - 1076-2752, 1076-2752
KW  - Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts
KW  - Mortality
KW  - Carcinogenicity
KW  - Emissions
KW  - Coke
KW  - Metal industry
KW  - Ethnic groups
KW  - Occupational exposure
KW  - Lung cancer
KW  - R2 23080:Industrial and labor
KW  - H 1000:Occupational Safety and Health
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-01-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Mortality; Carcinogenicity; Emissions; Coke; Metal industry; Occupational exposure; Ethnic groups; Lung cancer
DO  - http://dx.doi.org/10.1097/JOM.0b013e318154c094
ER  - 



TY  - JOUR
T1  - Genetic Diversity among Clonal Lineages within Escherichia coli O157:H7 Stepwise Evolutionary Model
AN  - 19464930; 8044006
AB  - Escherichia coli O157:H7 variants were examined for trait mutations and by molecular subtyping to better define clonal complexes postulated on the O157:H7 evolution model. Strains of beta -glucuronidase-positive, sorbitol-negative O157:H7 isolated in United States and Japan were identical to A5 clonal strain and shared sequence type (ST)-65 by multilocus sequence typing (MLST); thus, they belong in A5. However, these strains exhibited pulsed-field gel electrophoresis (PFGE) profile differences that suggested genomic divergence between populations. Sorbitol-fermenting O157 (SFO157) strains from Finland, Scotland, and Germany were identical to A4 clonal strain and belong in A4. Some SFO157 strains, isolated years apart and from different countries, had identical PFGE profiles, suggesting a common origin. Despite similarities, some Finnish and Scottish and all of the German strains have ST-75 ("German clone"), whereas others have ST-76, a new variant ("Scottish clone"). MLST of strains in other clonal complexes also discriminated strains thought to be identical and showed that genetic differences will further distinguish clonal populations into subclones.
JF  - Emerging Infectious Diseases
AU  - Feng, PCH
AU  - Monday
AU  - Lacher, D W
AU  - Allison, L
AU  - Siitonen, A
AU  - Keys, C
AU  - Eklund, M
AU  - Nagano, H
AU  - Karch, H
AU  - Keen, J
AU  - Whittam, T S
AD  - Food and Drug Administration, College Park, Maryland, USA
Y1  - 2007/11//
PY  - 2007
DA  - Nov 2007
VL  - 13
IS  - 11
SN  - 1080-6040, 1080-6040
KW  - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts
KW  - Molecular modelling
KW  - Escherichia coli
KW  - Pulsed-field gel electrophoresis
KW  - Genetic diversity
KW  - genomics
KW  - Mutation
KW  - Evolution
KW  - multilocus sequence typing
KW  - Models
KW  - J 02310:Genetics & Taxonomy
KW  - W 30900:Methods
KW  - G 07770:Bacteria
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-03-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Molecular modelling; Pulsed-field gel electrophoresis; Genetic diversity; genomics; Mutation; Evolution; Models; multilocus sequence typing; Escherichia coli
ER  - 



TY  - JOUR
T1  - A New Zealand outbreak of norovirus gastroenteritis linked to the consumption of imported raw Korean oysters.
AN  - 68455409; 17972982
AB  - To investigate an outbreak of gastroenteritis that occurred following an international rugby test at Eden Park (Auckland, New Zealand) on 17 June 2006.
          387 patrons were interviewed. Cases were defined as those from one of four hospitality areas who consumed food or beverage at Eden Park on the evening of 17 June 2006 and subsequently suffered from diarrhoea or vomiting; or, stomach cramps and nausea. A case-control study was conducted and food and beverage items associated with illness were identified. Clinical specimens were requested from patrons and food handlers, and leftover foods were analysed for pathogens. A food safety assessment was conducted at the implicated catering premises. A total of 115 cases were identified. Attack rates varied between the four hospitality areas from 8% to 47%. Predominant symptoms among cases included nausea, vomiting, diarrhoea, stomach cramps, fever, and chills. The consumption of several foods was associated with an increased risk of illness but the strongest was for raw oysters consumed in Hospitality Area 1 (Risk Ratio 11.9; 95%CI 3.9-36.1; p<0.00001), attack rate 65%. Norovirus (genogroups I and II) was detected in samples provided by four of the cases and three unopened packets of implicated batches of imported Korean Pacific oysters (Crassostrea gigas) linked to the outbreak. This outbreak resulted from consumption of raw imported Korean oysters contaminated by norovirus. Labelling recommending cooking prior to consumption failed to prevent the outbreak.
JF  - The New Zealand medical journal
AU  - Simmons, Greg
AU  - Garbutt, Claire
AU  - Hewitt, Joanne
AU  - Greening, Gail
AD  - Population Protection Group, Auckland Regional Public Health Service, Auckland. gregs@adhb.govt.nz
Y1  - 2007/10/26/
PY  - 2007
DA  - 2007 Oct 26
SP  - 1
VL  - 120
IS  - 1264
KW  - Index Medicus
KW  - Animals
KW  - Humans
KW  - Feces -- virology
KW  - Case-Control Studies
KW  - Salmon -- virology
KW  - Korea
KW  - New Zealand -- epidemiology
KW  - Disease Reservoirs -- virology
KW  - Risk Assessment
KW  - Ostreidae -- virology
KW  - Gastroenteritis -- virology
KW  - Food Microbiology
KW  - Norovirus -- isolation & purification
KW  - Disease Outbreaks
KW  - Gastroenteritis -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-07
N1  - Date created - 2007-11-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - Anti-TNFa Therapy Rescues Neonatal Mice from Lethal Arenavirus -Induced Meningoencephalitis.
T2  - Fifteenth Annual Meeting of the International Cytokine Society
AN  - 40715478; 4756348
JF  - Fifteenth Annual Meeting of the International Cytokine Society
AU  - Pedras-Vasconcelos, Joao A
AU  - Puig, Montserrat
AU  - Sauder, Christian
AU  - Verthelyi, Daniela
Y1  - 2007/10/26/
PY  - 2007
DA  - 2007 Oct 26
KW  - Mice
KW  - Meningoencephalitis
KW  - Neonates
KW  - Therapy
KW  - Arenavirus
KW  - U 2000:Biological Sciences
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Anti-TNFa+Therapy+Rescues+Neonatal+Mice+from+Lethal+Arenavirus+-Induced+Meningoencephalitis.&rft.au=Pedras-Vasconcelos%2C+Joao+A%3BPuig%2C+Montserrat%3BSauder%2C+Christian%3BVerthelyi%2C+Daniela&rft.aulast=Pedras-Vasconcelos&rft.aufirst=Joao&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/
L2  - http://www.cytokines2007.org/abstracts2.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Human Genotyping Using Next Generation Sequencing Technology.
T2  - 2007 International Conference of the American Society of Human Genetics (ASHG 2007)
AN  - 40707112; 4752276
JF  - 2007 International Conference of the American Society of Human Genetics (ASHG 2007)
AU  - Xiao, N
AU  - Desany, B
AU  - Bouffard, P
AU  - Burdett, L A
AU  - Welch, R
AU  - Yeager, M
AU  - Jarvie, T P
AU  - Harkins, T T
AU  - Qi, L.
AU  - Lu, J.
AU  - Chanock, S J
Y1  - 2007/10/23/
PY  - 2007
DA  - 2007 Oct 23
KW  - Technology
KW  - Genotyping
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40707112?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Human+Genotyping+Using+Next+Generation+Sequencing+Technology.&rft.au=Xiao%2C+N%3BDesany%2C+B%3BBouffard%2C+P%3BBurdett%2C+L+A%3BWelch%2C+R%3BYeager%2C+M%3BJarvie%2C+T+P%3BHarkins%2C+T+T%3BQi%2C+L.%3BLu%2C+J.%3BChanock%2C+S+J&rft.aulast=Xiao&rft.aufirst=N&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Common Variation at 8q24 and Prostate Cancer Risk.
T2  - 2007 International Conference of the American Society of Human Genetics (ASHG 2007)
AN  - 40706416; 4752302
JF  - 2007 International Conference of the American Society of Human Genetics (ASHG 2007)
AU  - Yeager-Jeffery, M
AU  - Welch, R
AU  - Hayes, R B
AU  - Bouffard, P
AU  - Xiao, N
AU  - Burdett, L
AU  - Orr, N
AU  - Crenshaw, A
AU  - Markovic, Z
AU  - Jacobs, K B
AU  - Jarvie, T P
AU  - Hunter, D
AU  - Hoover, R
AU  - Thomas, G
AU  - Harkins, T T
AU  - Chanock, S J
Y1  - 2007/10/23/
PY  - 2007
DA  - 2007 Oct 23
KW  - Prostate cancer
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40706416?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Common+Variation+at+8q24+and+Prostate+Cancer+Risk.&rft.au=Yeager-Jeffery%2C+M%3BWelch%2C+R%3BHayes%2C+R+B%3BBouffard%2C+P%3BXiao%2C+N%3BBurdett%2C+L%3BOrr%2C+N%3BCrenshaw%2C+A%3BMarkovic%2C+Z%3BJacobs%2C+K+B%3BJarvie%2C+T+P%3BHunter%2C+D%3BHoover%2C+R%3BThomas%2C+G%3BHarkins%2C+T+T%3BChanock%2C+S+J&rft.aulast=Yeager-Jeffery&rft.aufirst=M&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-27
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma.
AN  - 68403958; 17942922
AB  - Targeting cell surface receptors with cytotoxins or immunotoxins provides a unique opportunity for tumor therapy. Here, we show the efficacy of the combination therapy of gemcitabine with an interleukin-4 (IL-4) cytotoxin composed of IL-4 and truncated Pseudomonas exotoxin in animal models of pancreatic ductal adenocarcinoma (PDA). We have observed that 42 of 70 (60%) tumor samples from patients with PDA express moderate- to high-density surface IL-4 receptor (IL-4R), whereas normal pancreatic samples express no or low-density IL-4R. IL-4 cytotoxin was specifically and highly cytotoxic [50% protein synthesis inhibition (IC50) ranging from >0.1 to 13 ng/mL] to six of eight pancreatic cancer cell lines, whereas no cytotoxicity (IC50>1,000 ng/mL) was observed in normal human pancreatic duct epithelium cells, fibroblasts, and human umbilical vein endothelial cells (HUVEC). We also showed that IL-4 cytotoxin in combination with gemcitabine exhibited synergistic antitumor activity in vitro. To confirm synergistic antitumor activity in vivo and monitor precise real-time disease progression, we used a novel metastatic and orthotopic mouse model using green fluorescent protein-transfected cancer cells and whole-body imaging system. The combination of both agents caused complete eradication of tumors in 40% of nude mice with small established PDA tumors. In addition, combined treatment significantly prolonged the survival of nude mice bearing day 14 advanced distant metastatic PDA tumors. Similar results were observed in mice xenografted with PDA obtained from a patient undergoing surgical resection. These results indicate that IL-4 cytotoxin combined with gemcitabine may provide effective therapy for the treatment of patients with PDA.
JF  - Cancer research
AU  - Shimamura, Takeshi
AU  - Royal, Richard E
AU  - Kioi, Mitomu
AU  - Nakajima, Atsushi
AU  - Husain, Syed R
AU  - Puri, Raj K
AD  - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH, Bethesda, MD 20892, USA.
Y1  - 2007/10/15/
PY  - 2007
DA  - 2007 Oct 15
SP  - 9903
EP  - 9912
VL  - 67
IS  - 20
SN  - 0008-5472, 0008-5472
KW  - Leukocidins
KW  - 0
KW  - Pseudomonas aeruginosa Cytotoxins
KW  - Receptors, Interleukin-4
KW  - Recombinant Fusion Proteins
KW  - Deoxycytidine
KW  - 0W860991D6
KW  - Green Fluorescent Proteins
KW  - 147336-22-9
KW  - Interleukin-4
KW  - 207137-56-2
KW  - gemcitabine
KW  - B76N6SBZ8R
KW  - Index Medicus
KW  - Recombinant Fusion Proteins -- metabolism
KW  - Receptors, Interleukin-4 -- biosynthesis
KW  - Animals
KW  - Receptors, Interleukin-4 -- metabolism
KW  - Transfection
KW  - Humans
KW  - Recombinant Fusion Proteins -- genetics
KW  - Xenograft Model Antitumor Assays
KW  - Mice, Nude
KW  - Mice
KW  - Cell Line, Tumor
KW  - Drug Synergism
KW  - Recombinant Fusion Proteins -- administration & dosage
KW  - Green Fluorescent Proteins -- genetics
KW  - Interleukin-4 -- genetics
KW  - Interleukin-4 -- metabolism
KW  - Pancreatic Neoplasms -- metabolism
KW  - Carcinoma, Pancreatic Ductal -- metabolism
KW  - Deoxycytidine -- analogs & derivatives
KW  - Carcinoma, Pancreatic Ductal -- drug therapy
KW  - Leukocidins -- administration & dosage
KW  - Leukocidins -- genetics
KW  - Deoxycytidine -- administration & dosage
KW  - Antineoplastic Combined Chemotherapy Protocols -- pharmacology
KW  - Pancreatic Neoplasms -- drug therapy
KW  - Interleukin-4 -- administration & dosage
KW  - Deoxycytidine -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-12
N1  - Date created - 2007-10-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Carbaryl exposure and incident cancer in the Agricultural Health Study.
AN  - 68202203; 17534892
AB  - Carbaryl is a carbamate insecticide with a broad spectrum of uses in agricultural, commercial and household settings. It has previously been linked with non-Hodgkin lymphoma (NHL) but studies of cancer risk in humans are limited. We examined occupational carbaryl use and risk of all cancers in the Agricultural Health Study, a prospective study of a cohort of pesticide applicators in North Carolina and Iowa. This analysis included 21,416 subjects (1,291 cases) enrolled from 1993-1997 and followed for cancer incidence through 2003. Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs) while controlling for potential confounders. Carbaryl was not associated with cancer risk overall. Relative to subjects who never used carbaryl, melanoma risk was elevated with >175 lifetime exposure-days (RR = 4.11; 95%CI, 1.33-12.75; p-trend = 0.07), >10 years of use (RR = 3.19; 95%CI, 1.28-7.92; p-trend = 0.04), or >or=10 days of use per year (RR = 5.50; 95%CI, 2.19-13.84; p-trend < 0.001). Risk remained after adjusting for sunlight exposure. Although not significant, there appeared to be a trend of decreasing prostate cancer risk with increasing level of exposure. A small increase in NHL risk was observed using some, but not all, exposure measures. No associations were observed with other examined cancer sites. Because the observed results were not hypothesized a priori and because of limited study of their biological plausibility, they should be interpreted with caution.
          (c) 2007 Wiley-Liss, Inc.
JF  - International journal of cancer
AU  - Mahajan, Rajeev
AU  - Blair, Aaron
AU  - Coble, Joseph
AU  - Lynch, Charles F
AU  - Hoppin, Jane A
AU  - Sandler, Dale P
AU  - Alavanja, Michael C R
AD  - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA.
Y1  - 2007/10/15/
PY  - 2007
DA  - 2007 Oct 15
SP  - 1799
EP  - 1805
VL  - 121
IS  - 8
SN  - 0020-7136, 0020-7136
KW  - Insecticides
KW  - 0
KW  - Carbaryl
KW  - R890C8J3N1
KW  - Index Medicus
KW  - Odds Ratio
KW  - Prostatic Neoplasms -- epidemiology
KW  - Humans
KW  - Aged
KW  - Poisson Distribution
KW  - North Carolina -- epidemiology
KW  - Melanoma -- epidemiology
KW  - Lymphoma, Non-Hodgkin -- epidemiology
KW  - Prospective Studies
KW  - Adult
KW  - Confounding Factors (Epidemiology)
KW  - Skin Neoplasms -- epidemiology
KW  - Incidence
KW  - Middle Aged
KW  - Female
KW  - Iowa -- epidemiology
KW  - Male
KW  - Insecticides -- toxicity
KW  - Neoplasms -- chemically induced
KW  - Neoplasms -- epidemiology
KW  - Occupational Exposure -- adverse effects
KW  - Occupational Diseases -- epidemiology
KW  - Carbaryl -- toxicity
KW  - Occupational Diseases -- chemically induced
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68202203?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Carbaryl+exposure+and+incident+cancer+in+the+Agricultural+Health+Study.&rft.au=Mahajan%2C+Rajeev%3BBlair%2C+Aaron%3BCoble%2C+Joseph%3BLynch%2C+Charles+F%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+C+R&rft.aulast=Mahajan&rft.aufirst=Rajeev&rft.date=2007-10-15&rft.volume=121&rft.issue=8&rft.spage=1799&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-29
N1  - Date created - 2007-08-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - Lived Mental Stress of Adolescents of Color in Foster Care.
T2  - 6th World Congress on Stress
AN  - 39477248; 4675004
JF  - 6th World Congress on Stress
AU  - Scott, Ella M
Y1  - 2007/10/11/
PY  - 2007
DA  - 2007 Oct 11
KW  - Adolescents
KW  - Stress
KW  - Color
KW  - U 2000:Biological Sciences
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Stress&rft.atitle=Lived+Mental+Stress+of+Adolescents+of+Color+in+Foster+Care.&rft.au=Scott%2C+Ella+M&rft.aulast=Scott&rft.aufirst=Ella&rft.date=2007-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Stress&rft.issn=&rft_id=info:doi/
L2  - http://www.icms.com.au/stress2007/grid.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Antisocial behavioral syndromes and DSM-IV drug use disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions
AN  - 57234062; 200804150
AB  - Background Antisocial behavioral syndromes, including antisocial personality disorder (ASPD), syndromal adult antisocial behavior (AABS) without conduct disorder (CD) before age 15, and CD without progression to ASPD ('CD only') are highly comorbid with drug use disorders (DUDs). Among patients in DUD treatment, antisocial syndromes are associated with greater severity and poorer outcomes. Comparative data concerning associations of antisocial syndromes with clinical characteristics of DUDs among general population adults have not previously been available. This study describes associations of antisocial syndromes with clinical characteristics of lifetime Diagnostic and Statistical Manual-Version IV DUDs in the general U.S. adult population. Methods This report is based on the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (n=43,093, response rate=81%). Respondents (n=4068) with lifetime DUDs were classified according to whether they met criteria for ASPD, AABS, 'CD only,' or no antisocial syndrome. Associations of antisocial syndromes with clinical characteristics of DUDs were examined using logistic regression. Results Antisocial syndromes were significantly associated with the phenomenology of DUDs, particularly ASPD with the most severe clinical presentations. Associations with AABS were similar to those with ASPD; those with 'CD only' were weak, inconsistent, and not statistically significant. Patterns of associations differed little between men and women. Conclusions Both ASPD and AABS, but not 'CD only,' appear to identify greater clinical severity of DUDs among adults in the general U.S. population. [Copyright 2007 Elsevier Ireland Ltd.]
JF  - Drug and Alcohol Dependence
AU  - Goldstein, Rise B
AU  - Compton, Wilson M
AU  - Pulay, Attila J
AU  - Ruan, W June
AU  - Pickering, Roger P
AU  - Stinson, Frederick S
AU  - Grant, Bridget F
AD  - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Y1  - 2007/10/08/
PY  - 2007
DA  - 2007 Oct 08
SP  - 145
EP  - 158
PB  - Elsevier Ireland, Amsterdam The Netherlands
VL  - 90
IS  - 2-3
SN  - 0376-8716, 0376-8716
KW  - Antisocial personality disorder
KW  - Conduct disorder
KW  - Drug use disorders
KW  - Conduct disorders
KW  - Antisocial behaviour
KW  - Drug abuse
KW  - article
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Antisocial+behavioral+syndromes+and+DSM-IV+drug+use+disorders+in+the+United+States%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Goldstein%2C+Rise+B%3BCompton%2C+Wilson+M%3BPulay%2C+Attila+J%3BRuan%2C+W+June%3BPickering%2C+Roger+P%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Goldstein&rft.aufirst=Rise&rft.date=2007-10-08&rft.volume=90&rft.issue=2-3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.02.023
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-03-04
N1  - Last updated - 2016-09-27
N1  - CODEN - DADEDV
N1  - SubjectsTermNotLitGenreText - Antisocial behaviour; Conduct disorders; Drug abuse
DO  - http://dx.doi.org/10.1016/j.drugalcdep.2007.02.023
ER  - 



TY  - CPAPER
T1  - Differences in Adult and Neonatal BAFF/APRIL System: Implications for Polysaccharide Vaccines
T2  - 2007 Keystone Symposia on Challenges of Global Vaccine Development (T1)
AN  - 39576600; 4721942
JF  - 2007 Keystone Symposia on Challenges of Global Vaccine Development (T1)
AU  - Akkoyunlu, Mustafa
Y1  - 2007/10/08/
PY  - 2007
DA  - 2007 Oct 08
KW  - Vaccines
KW  - BLyS protein
KW  - Neonates
KW  - Polysaccharides
KW  - APRIL protein
KW  - Disease control
KW  - U 2000:Biological Sciences
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L2  - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=90 5&subTab=program
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Statistics for risk assessment of chemical carcinogens.
AN  - 68504199; 18000784
AB  - Risk assessment is a scientific process of evaluation of potential health risks of chemical exposures to humans from available information. It involves analysis of the relationship between exposure and health related outcomes to derive an allowable exposure level. Because of lack of human exposure data, the major source of information for studying potential health effects of chemicals on humans is generally obtained from animal dose response experiments. Animal data are often evaluated in two aspects via statistical analysis: qualitative testing and quantitative estimation. The qualitative testing is to determine if the chemical causes an adverse health effect, i.e., if there is a statistically significant difference between treated and control animals. Quantitative estimation involves fitting a dose-response model to derive an allowable exposure level for humans. This paper reviews statistical principles and procedures for qualitative and quantitative approaches to human risk assessment.
JF  - Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
AU  - Chen, James J
AU  - Chen, Yi-Ju
AU  - Cheng, Kuang Fu
AD  - Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. jamesj.chen@fda.hhs.gov
PY  - 2007
SP  - 281
EP  - 312
VL  - 25
IS  - 4
SN  - 1059-0501, 1059-0501
KW  - Carcinogens
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Risk Assessment -- statistics & numerical data
KW  - Neoplasms -- chemically induced
KW  - Carcinogens -- toxicity
KW  - Models, Statistical
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.atitle=Statistics+for+risk+assessment+of+chemical+carcinogens.&rft.au=Chen%2C+James+J%3BChen%2C+Yi-Ju%3BCheng%2C+Kuang+Fu&rft.aulast=Chen&rft.aufirst=James&rft.date=2007-10-01&rft.volume=25&rft.issue=4&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.issn=10590501&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-18
N1  - Date created - 2007-11-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Role of lubrication oil in particulate emissions from a hydrogen-powered internal combustion engine.
AN  - 68445684; 17969702
AB  - Recent studies suggest that trace metals emitted by internal combustion engines are derived mainly from combustion of lubrication oil. This hypothesis was examined by investigation of the formation of particulate matter emitted from an internal combustion engine in the absence of fuel-derived soot. Emissions from a modified CAT 3304 diesel engine fueled with hydrogen gas were characterized. The role of organic carbon and metals from lubrication oil on particle formation was investigated under selected engine conditions. The engine produced exhaust aerosol with log normal-size distributions and particle concentrations between 10(5) and 10(7) cm(-3) with geometric mean diameters from 18 to 31 nm. The particles contained organic carbon, little or no elemental carbon, and a much larger percentage of metals than particles from diesel engines. The maximum total carbon emission rate was estimated at 1.08 g h(-1), which is much lower than the emission rate of the original diesel engine. There was also evidence that less volatile elements, such as iron, self-nucleated to form nanoparticles, some of which survive the coagulation process.
JF  - Environmental science & technology
AU  - Miller, Arthur L
AU  - Stipe, Christopher B
AU  - Habjan, Matthew C
AU  - Ahlstrand, Gilbert G
AD  - National Institute for Occupational Safety and Health, Spokane, Washington 99207 Mechanical Engineering Department, Seattle University, Seattle, Washington 98122, USA. ALMiller@cdc.gov
Y1  - 2007/10/01/
PY  - 2007
DA  - 2007 Oct 01
SP  - 6828
EP  - 6835
VL  - 41
IS  - 19
SN  - 0013-936X, 0013-936X
KW  - Air Pollutants
KW  - 0
KW  - Metals
KW  - Particulate Matter
KW  - Vehicle Emissions
KW  - Carbon
KW  - 7440-44-0
KW  - Hydrogen
KW  - 7YNJ3PO35Z
KW  - Index Medicus
KW  - Lubrication
KW  - Particle Size
KW  - Carbon -- analysis
KW  - Metals -- analysis
KW  - Industrial Oils
KW  - Air Pollutants -- analysis
KW  - Particulate Matter -- analysis
KW  - Vehicle Emissions -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-24
N1  - Date created - 2007-10-30
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Evaluation of an in vitro bioassay for the detection of purified ricin and castor bean in beverages and liquid food matrices.
AN  - 68443943; 17969621
AB  - The potential use of ricin as a biological weapon in food highlights the necessity for the development of food-specific detection methods. Current methods for the detection of ricin consist of various immunoassays, which detect only one subunit of the ricin toxin and therefore may not be indicative of a biologically active molecule. An in vivo assay, such as a mouse bioassay, can indicate the biological activity of the toxin; however, this method is not feasible for laboratories that do not have animal testing facilities. The purpose of this study was to develop an in vitro assay for the detection of biologically active ricin in beverages and liquid foods. Acidic and high-protein beverages were spiked with either purified ricin or ground castor beans and added to cultured human Jurkat cells. After an overnight incubation, the supernatant was tested for lactate dehydrogenase (LDH) activity with a colorimetric assay. LDH was released from the cytosol upon cell damage and was positively correlated with cell death. Ricin was detectable in all the matrices tested, with a sensitivity of 10 to 100 pg/ml. Biologically active ricin was detectable in all the matrices incubated with ground castor bean material. This method provides a confirmatory way to detect biologically active ricin that can be utilized by laboratories lacking animal facilities.
JF  - Journal of food protection
AU  - Brzezinski, Jennifer L
AU  - Craft, David L
AD  - U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, Ohio 45237, USA. jennifer.brzezinski@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 2377
EP  - 2382
VL  - 70
IS  - 10
SN  - 0362-028X, 0362-028X
KW  - Ricin
KW  - 9009-86-3
KW  - L-Lactate Dehydrogenase
KW  - EC 1.1.1.27
KW  - Index Medicus
KW  - Sensitivity and Specificity
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Biological Assay
KW  - Colorimetry
KW  - Bioterrorism
KW  - L-Lactate Dehydrogenase -- metabolism
KW  - Jurkat Cells -- drug effects
KW  - Castor Bean -- chemistry
KW  - Beverages -- analysis
KW  - Jurkat Cells -- enzymology
KW  - Food Contamination -- analysis
KW  - Ricin -- isolation & purification
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-06
N1  - Date created - 2007-10-30
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma.
AN  - 68440943; 17962618
AB  - On October 6, 2006, the U.S. Food and Drug Administration granted regular approval to vorinostat (Zolinza(R); Merck & Co., Inc., Whitehouse Station, NJ), a histone deacetylase inhibitor, for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma (CTCL) in patients with progressive, persistent, or recurrent disease on or following two systemic therapies. The pivotal study supporting approval was a single-arm open-label phase II trial that enrolled 74 patients with stage IB and higher CTCL who had failed two systemic therapies (one of which must have contained bexarotene). Patients received vorinostat at a dose of 400 mg orally once daily, which could be reduced for toxicity to 300 mg daily or 300 mg 5 days a week. The median age of patients was 61 years. Sixty-one patients (82%) had stage IIB or higher CTCL and 30 patients (41%) had Sézary syndrome. The median duration of protocol treatment was 118 days. The primary efficacy endpoint was objective response assessed by the Severity-Weighted Assessment Tool. The objective response rate was 30% (95% confidence interval [CI], 19.7%-41.5%), the estimated median response duration was 168 days, and the median time to tumor progression was 202 days. An additional single-center study enrolled 33 patients with similar baseline and demographic features as the pivotal trial. Thirteen of the 33 received vorinostat (400 mg/day). The response rate in these 13 patients was 31% (95% CI, 9.1%-61.4%). The most common clinical adverse events (AEs) of any grade were diarrhea (52%), fatigue (52%), nausea (41%), and anorexia (24%). Grade 3 or 4 clinical AEs included fatigue (4%) and pulmonary embolism (5%). Hematologic laboratory abnormalities included thrombocytopenia (26%) and anemia (14%). Chemistry laboratory abnormalities included increased creatinine (16%), increased serum glucose (69%), and proteinuria (51%). Most abnormalities were National Cancer Institute Common Terminology Criteria for Adverse Events grade 1 or 2. Grade 3 or greater chemistry abnormalities included hyperglycemia, hypertriglyceridemia, and hyperuricemia, hypoglycemia, hypokalemia, hyponatremia, hyperkalemia, hypercholesterolemia, hypophosphatemia, and increased creatinine.
JF  - The oncologist
AU  - Mann, Bhupinder S
AU  - Johnson, John R
AU  - Cohen, Martin H
AU  - Justice, Robert
AU  - Pazdur, Richard
AD  - Division of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, USA. bhupinder.mann@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 1247
EP  - 1252
VL  - 12
IS  - 10
SN  - 1083-7159, 1083-7159
KW  - Antineoplastic Agents
KW  - 0
KW  - Histone Deacetylase Inhibitors
KW  - Hydroxamic Acids
KW  - vorinostat
KW  - 58IFB293JI
KW  - Index Medicus
KW  - United States
KW  - Administration, Oral
KW  - Neoplasm Staging
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Salvage Therapy
KW  - Aged
KW  - Drug Resistance, Neoplasm
KW  - United States Food and Drug Administration
KW  - Survival Rate
KW  - Aged, 80 and over
KW  - Drug Approval
KW  - Adult
KW  - Treatment Outcome
KW  - Middle Aged
KW  - Follow-Up Studies
KW  - Maximum Tolerated Dose
KW  - Female
KW  - Male
KW  - Skin Neoplasms -- drug therapy
KW  - Hydroxamic Acids -- therapeutic use
KW  - Skin Neoplasms -- pathology
KW  - Lymphoma, T-Cell, Cutaneous -- pathology
KW  - Antineoplastic Agents -- therapeutic use
KW  - Lymphoma, T-Cell, Cutaneous -- drug therapy
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-06
N1  - Date created - 2007-10-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Inter-rater agreement for a retrospective exposure assessment of asbestos, chromium, nickel and welding fumes in a study of lung cancer and ionizing radiation.
AN  - 68402303; 17846032
AB  - A retrospective exposure assessment of asbestos, welding fumes, chromium and nickel (in welding fumes) was conducted at the Portsmouth Naval Shipyard for a nested case-control study of lung cancer risk from external ionizing radiation. These four contaminants were included because of their potential to confound or modify the effect of a lung cancer-radiation relationship. The exposure assessment included three experienced industrial hygienists from the shipyard who independently assessed exposures for 3519 shop/job/time period combinations. A consensus process was used to resolve estimates with large differences. Final exposure estimates were linked to employment histories of the 4388 study subjects to calculate their cumulative exposures. Inter-rater agreement analyses were performed on the original estimates to better understand the estimation process. Although concordance was good to excellent (78-99%) for intensity estimates and excellent (96-99%) for frequency estimates, overall simple kappa statistics indicated only slight agreement beyond chance (kappa < 0.2). Unbalanced distributions of exposure estimates partly contributed to the weak observed overall inter-rater agreement. Pairwise weighted kappa statistics revealed better agreement between two of the three panelists (kappa = 0.19-0.65). The final consensus estimates were similar to the estimates made by these same two panelists. Overall welding fume exposures were fairly stable across time at the shipyard while asbestos exposures were higher in the early years and fell in the mid-1970s. Mean cumulative exposure for all study subjects was 520 fiber-days cc(-1) for asbestos and 1000 mg-days m(-3) for welding fumes. Mean exposure was much lower for nickel (140 microg-days m(-3)) and chromium (45 microg-days m(-3)). Asbestos and welding fume exposure estimates were positively associated with lung cancer in the nested case-control study. The radiation-lung cancer relationship was attenuated by the inclusion of these two confounders. This exposure assessment provided exposure estimates that aided in understanding of the lung cancer-radiation relationship at the shipyard.
JF  - The Annals of occupational hygiene
AU  - Seel, E A
AU  - Zaebst, D D
AU  - Hein, M J
AU  - Liu, J
AU  - Nowlin, S J
AU  - Chen, P
AD  - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. lseel@cdc.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 601
EP  - 610
VL  - 51
IS  - 7
SN  - 0003-4878, 0003-4878
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Chromium
KW  - 0R0008Q3JB
KW  - Asbestos
KW  - 1332-21-4
KW  - Index Medicus
KW  - Asbestos -- analysis
KW  - Chromium -- analysis
KW  - Humans
KW  - Confounding Factors (Epidemiology)
KW  - Case-Control Studies
KW  - Welding
KW  - Observer Variation
KW  - Lung Neoplasms -- etiology
KW  - Neoplasms, Radiation-Induced -- etiology
KW  - Air Pollutants, Occupational -- analysis
KW  - Occupational Diseases -- etiology
KW  - Occupational Exposure -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-04-16
N1  - Date created - 2007-10-17
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase.
AN  - 68396079; 17938735
AB  - Aberrant DNA methylation is common in carcinogenesis. The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation.
          During cadmium-induced malignant transformation, an unusual pattern of genomic hypermethylation occurred that we studied to provide insight into the roles of specific DNMTs in oncogenesis. Gene expression and DNA methylation were assessed in control and chronic cadmium-transformed prostate epithelial cells (CTPE) using reverse transcription-polymerase chain reaction (RT-PCR), Western blot analysis, methylation-specific PCR, and methyl acceptance assay.
          During the 10-weeks of cadmium exposure that induced malignant transformation, progressive increases in generalized DNMT enzymatic activity occurred that were associated with over-expression of DNMT3b without changes in DNMT1 expression. Increased DNMT3b expression preceded increased DNMT enzymatic activity. Procainamide, a specific DNMT1 inhibitor, reversed cadmium-induced genomic DNA hypermethylation. Reduced expression of the tumor suppressor genes, RASSF1A and p16, began about the time DNMT3b overexpression first occurred and progressively decreased thereafter. RASSF1A and p16 promoter regions were heavily methylated in CTPE cells, indicating silencing by hypermethylation, while the DNA demethylating agent, 5-aza-2'-deoxycytidine, reversed this silencing. DNMT1 inhibition only modestly increased RASSF1A and p16 expression in CTPE cells and did not completely reverse silencing. These data indicate that DNMT3b overexpression can result in generalized DNA hypermethylation and gene silencing but that DNMT1 is required to maintain these effects. The pattern of genomic DNA hypermethylation together with up-regulation of DNMT3b may provide a unique set of biomarkers to specifically identify cadmium-induced human prostate cancers.
JF  - Environmental health perspectives
AU  - Benbrahim-Tallaa, Lamia
AU  - Waterland, Robert A
AU  - Dill, Anna L
AU  - Webber, Mukta M
AU  - Waalkes, Michael P
AD  - Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 1454
EP  - 1459
VL  - 115
IS  - 10
SN  - 0091-6765, 0091-6765
KW  - Carcinogens, Environmental
KW  - 0
KW  - Cadmium
KW  - 00BH33GNGH
KW  - DNA (Cytosine-5-)-Methyltransferase
KW  - EC 2.1.1.37
KW  - DNA (cytosine-5-)-methyltransferase 1
KW  - DNA methyltransferase 3B
KW  - Index Medicus
KW  - prostate
KW  - p16
KW  - carcinogenesis
KW  - DNMT3b
KW  - cadmium
KW  - DNA methylation
KW  - RASSF1A
KW  - Gene Expression Profiling
KW  - Epithelial Cells -- drug effects
KW  - Genes, Tumor Suppressor -- drug effects
KW  - DNA (Cytosine-5-)-Methyltransferase -- drug effects
KW  - Cells, Cultured
KW  - Humans
KW  - Case-Control Studies
KW  - Up-Regulation
KW  - DNA (Cytosine-5-)-Methyltransferase -- metabolism
KW  - Male
KW  - Prostate -- drug effects
KW  - DNA Methylation -- drug effects
KW  - Cell Transformation, Neoplastic -- chemically induced
KW  - Cadmium -- toxicity
KW  - Gene Expression Regulation -- drug effects
KW  - Carcinogens, Environmental -- toxicity
KW  - Prostate -- cytology
KW  - Cell Transformation, Neoplastic -- genetics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-26
N1  - Date created - 2007-10-16
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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Int J Cancer. 2005 Apr 10;114(3):346-55 [15551354]
Cancer Lett. 2005 Aug 8;226(1):77-84 [16004934]
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Cancer Res. 2006 Jan 15;66(2):729-35 [16424002]
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J Environ Pathol Toxicol Oncol. 2000;19(3):307-18 [10983897]
Cancer Res. 2001 Jan 15;61(2):455-8 [11212230]
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Mutat Res. 2003 Dec 10;533(1-2):107-20 [14643415]
Cancer Res. 2002 Jun 15;62(12):3498-502 [12067994]
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Exp Cell Res. 2003 Jun 10;286(2):355-65 [12749863]
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Cancer Cells. 1991 Oct;3(10):383-90 [1777359]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The US national antimicrobial resistance monitoring system.
AN  - 68374886; 17927472
AB  - The use of antimicrobial agents in food animals can select for resistant bacterial pathogens that may be transmitted to humans via the commercial meat supply. In the USA, the FDA's Center for Veterinary Medicine regulatory duties require a determination that antimicrobial drugs are safe and effective for use in food animals. In addition, a qualitative assessment of risks to human health from antimicrobial resistance requires development. This risk assessment process is supported by data generated by the FDA's National Antimicrobial Resistance Monitoring System (NARMS) for enteric bacteria. NARMS data on antimicrobial susceptibility among Salmonella, Campylobacter, Escherichia coli and Enterococcus is collected. Research activities defining the genetic bases of resistance helps to understand the potential public health risks posed by the spread of antimicrobial resistance from food animal antimicrobial use. These activities help insure that antimicrobials are used judiciously to promote human and animal health.
JF  - Future microbiology
AU  - Gilbert, Jeffrey M
AU  - White, David G
AU  - McDermott, Patrick F
AD  - Center for Veterinary Medicine, US FDA, Office of New Animal Drug Evaluation 7500 Standish Place Rockville, MD 20855, USA. jeff.gilbert@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 493
EP  - 500
VL  - 2
IS  - 5
KW  - Anti-Infective Agents
KW  - 0
KW  - Index Medicus
KW  - United States
KW  - Animals
KW  - Animal Feed
KW  - United States Food and Drug Administration
KW  - Gram-Positive Bacterial Infections -- microbiology
KW  - Humans
KW  - Gram-Positive Bacteria -- growth & development
KW  - Gram-Negative Bacteria -- growth & development
KW  - Food Contamination
KW  - Gram-Negative Bacterial Infections -- microbiology
KW  - Food Microbiology
KW  - Drug Resistance, Microbial
KW  - Anti-Infective Agents -- administration & dosage
KW  - Meat -- microbiology
KW  - Food -- standards
KW  - Animals, Domestic -- microbiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68374886?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Future+microbiology&rft.atitle=The+US+national+antimicrobial+resistance+monitoring+system.&rft.au=Gilbert%2C+Jeffrey+M%3BWhite%2C+David+G%3BMcDermott%2C+Patrick+F&rft.aulast=Gilbert&rft.aufirst=Jeffrey&rft.date=2007-10-01&rft.volume=2&rft.issue=5&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Future+microbiology&rft.issn=1746-0921&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-27
N1  - Date created - 2007-10-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Investigation of reagent distributions on glass fiber membrane filters used in air sampling.
AN  - 68338770; 17909647
AB  - This project has arisen from the need to produce GFFs (glass fiber filters) bearing a thin and evenly distributed coating of a selected reagent in the equatorial plane for breakthrough studies. However, it has been discovered that today's two general techniques for coating GFFs (total immersion and application of reagent solution to GFFs) have usually produced unevenly distributed coatings of reagent in the equatorial plane. In addition, quantities of reagent on GFFs from commercial sources may vary widely in the same lot of coated GFFs. Consequences are variability in capacity of coated filters at the point of breakthrough and, perhaps, wasted reagent. Although today's reagent-coated filters may be satisfactory for routine air sampling, such filters may be unacceptable for precise breakthrough studies. Research has been conducted successfully to produce nearly evenly distributed coatings of reagents in the equatorial plane of GFFs by application of reagent solutions to the centers of GFFs which are resting on crisscrossing, fine, stainless-steel wire. Distributions of coatings have been determined by punching out twenty-one 5-mm circles from each GFF and analyzing each circle by flow-injection with a UV detector. Lowest achievable relative standard deviations of measurement (RSDs) for reagents in 5-mm circles have been 5 to 7%. Reagents studied have included 1-(2-pyridyl)piperazine (1-2PP), 2,4-dinitrophenylhydrazine (DNPH), and 1-(9-anthracenylmethyl)piperazine (MAP). Factors affecting the distribution of such coatings include choice of reagent and choice of solvent for the reagent solution.
JF  - Journal of environmental monitoring : JEM
AU  - Tucker, Samuel P
AD  - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. spt1@cdc.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 1122
EP  - 1130
VL  - 9
IS  - 10
SN  - 1464-0325, 1464-0325
KW  - 1-(9-anthracenylmethyl)piperazine
KW  - 0
KW  - Anthracenes
KW  - Indicators and Reagents
KW  - Membranes, Artificial
KW  - Phenylhydrazines
KW  - Phosphoric Acids
KW  - Piperazines
KW  - Solutions
KW  - fiberglass
KW  - 2,4-dinitrophenylhydrazine
KW  - 1N39KD7QPJ
KW  - phosphoric acid
KW  - E4GA8884NN
KW  - Index Medicus
KW  - Filtration
KW  - Piperazines -- chemistry
KW  - Anthracenes -- chemistry
KW  - Phenylhydrazines -- chemistry
KW  - Indicators and Reagents -- chemistry
KW  - Wettability
KW  - Phosphoric Acids -- chemistry
KW  - Glass -- chemistry
KW  - Air -- analysis
KW  - Environmental Monitoring -- instrumentation
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-25
N1  - Date created - 2007-10-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Improving depiction of benefits and harms: analyses of studies of well-known therapeutics and review of high-impact medical journals.
AN  - 68337221; 17909378
AB  - The issues of weighing benefits and harms and of shared decision-making have become increasingly important in recent years. There is limited knowledge and lack of adequate data on the most transparent method of communicating the information. In this article we discuss examples of communicating benefits and harms for well-known therapeutics, illustrating that relative risk estimates are not helpful for communicating the chance of experiencing adverse events. In addition, we show that asymmetric presentation of the data for benefits and harms is likely to bias toward showing greater benefits and diminishing the importance of the harms (or vice versa). We also present preliminary results of a brief review of high-impact medical journals that show limitations of current systematic reviews. In the review we found that every second published study does not discuss frequency data and 1 in 3 studies that report information on both benefits and harms does not report information in the same metric. We conclude that consistently depicting benefit and harm information in frequencies can substantially improve the communication of benefits and harms. Investigators should be requested to provide frequency data along with relative risk information in the publication of their scientific findings. Currently, even in the highest impact medical journals, evidence of benefits and harms is not consistently presented in ways that facilitate accurate interpretation.
JF  - Medical care
AU  - Sedrakyan, Artyom
AU  - Shih, Chuck
AD  - Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland, USA. asedraky@ahrq.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - S23
EP  - S28
VL  - 45
IS  - 10 Supl 2
SN  - 0025-7079, 0025-7079
KW  - Antipsychotic Agents
KW  - 0
KW  - Appetite Depressants
KW  - Aspirin, Dipyridamole Drug Combination
KW  - Contraceptives, Oral
KW  - Drug Combinations
KW  - Fibrinolytic Agents
KW  - Phenylpropanolamine
KW  - 33RU150WUN
KW  - Dipyridamole
KW  - 64ALC7F90C
KW  - Tissue Plasminogen Activator
KW  - EC 3.4.21.68
KW  - Aspirin
KW  - R16CO5Y76E
KW  - Index Medicus
KW  - Contraceptives, Oral -- adverse effects
KW  - Fibrinolytic Agents -- therapeutic use
KW  - Phenylpropanolamine -- adverse effects
KW  - Stroke -- therapy
KW  - Appetite Depressants -- adverse effects
KW  - Humans
KW  - Pharmacoepidemiology
KW  - Risk Assessment
KW  - Stroke -- epidemiology
KW  - Tissue Plasminogen Activator -- therapeutic use
KW  - Hormone Replacement Therapy -- adverse effects
KW  - Aspirin -- therapeutic use
KW  - Dipyridamole -- therapeutic use
KW  - Antipsychotic Agents -- adverse effects
KW  - Stroke -- chemically induced
KW  - Review Literature as Topic
KW  - Drug Evaluation
KW  - Evidence-Based Medicine
KW  - Information Dissemination
KW  - Decision Making
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-20
N1  - Date created - 2007-10-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The concomitant prescribing of ethinyl estradiol/drospirenone and potentially interacting drugs.
AN  - 68324295; 17900437
AB  - Ethinyl estradiol 0.03 mg/drospirenone 3 mg (EE/DRSP) contains a progestin drospirenone with antimineralocorticoid properties that may cause potassium retention leading to hyperkalemia. We estimated the percentage of EE/DRSP users prescribed concomitant potassium-sparing drugs [nonsteroidal antiinflammatory drugs, diuretics, angiotensin-converting enzyme inhibitors (with diuretics), angiotensin II agonists (with diuretics), and potassium chloride] between January 1, 2002, and March 31, 2005. We analyzed a population-based data set of 62,527 EE/DRSP users (Dimension Rx, Caremark). We compared the fill date and end date for each prescription (Rx) for an interacting drug to the start and end date for each EE/DRSP episode (linked Rxs). If a day of an interacting Rx overlapped with an EE/DRSP episode, concomitant prescribing was recorded.
          A total of 17.6% of the women concomitantly used EE/DRSP and an interacting drug. Twenty-nine percent of concomitant use occurred within a month of EE/DRSP initiation. Nonsteroidal antiinflammatory drugs and diuretics were most frequently used concomitantly with EE/DRSP. Forty percent of the women with concomitant use were 35 yearsof age or older at EE/DRSP initiation compared with 29% without concomitant use (p<.001). Obstetricians/gynecologists and family practitioners were the most common prescribers of EE/DRSP and potassium-sparing drugs, respectively.
          Concomitant prescribing of EE/DRSP and potassium-sparing drugs occurred frequently in our study population. As EE/DRSP becomes more widely used, physicians prescribing it should monitor patients for potassium-sparing drug use.
JF  - Contraception
AU  - McAdams, Mara
AU  - Staffa, Judy A
AU  - Dal Pan, Gerald J
AD  - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. mara.mcadams@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 278
EP  - 281
VL  - 76
IS  - 4
SN  - 0010-7824, 0010-7824
KW  - Androstenes
KW  - 0
KW  - Anti-Inflammatory Agents, Non-Steroidal
KW  - Contraceptives, Oral, Hormonal
KW  - Drug Combinations
KW  - Mineralocorticoid Receptor Antagonists
KW  - Sodium Channel Blockers
KW  - Ethinyl Estradiol
KW  - 423D2T571U
KW  - drospirenone
KW  - N295J34A25
KW  - Index Medicus
KW  - Drug Interactions
KW  - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use
KW  - Humans
KW  - Retrospective Studies
KW  - Contraceptives, Oral, Hormonal -- adverse effects
KW  - Practice Patterns, Physicians' -- statistics & numerical data
KW  - Medical Audit
KW  - Adult
KW  - Cohort Studies
KW  - Databases, Factual
KW  - Contraceptives, Oral, Hormonal -- therapeutic use
KW  - Female
KW  - Sodium Channel Blockers -- therapeutic use
KW  - Androstenes -- therapeutic use
KW  - Mineralocorticoid Receptor Antagonists -- therapeutic use
KW  - Ethinyl Estradiol -- adverse effects
KW  - Androstenes -- adverse effects
KW  - Hyperkalemia -- prevention & control
KW  - Hyperkalemia -- chemically induced
KW  - Ethinyl Estradiol -- therapeutic use
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-15
N1  - Date created - 2007-09-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig.
AN  - 68294441; 17622572
AB  - Chemically modified hemoglobin (Hb) solutions are promising oxygen therapeutics; however, these agents are prone to intravascular oxidation. Using a 50% exchange transfusion (ET) model with bovine polymerized hemoglobin (PolyHbBv), we examined heme oxidation, oxygenation markers, and toxicokinetics in rats, an ascorbic acid (AA)-producing species, and in guinea pigs, a non-AA-producing species. Plasma AA decreased by 50% in guinea pigs after ET, but it was unchanged in rats for the first 20 h post-ET. Both species cleared PolyHbBv from the circulation at similar rates. However, exposure to ferric PolyHbBv over time was 5-fold greater in the guinea pig. Mass spectrometry analysis of plasma revealed oxidative modifications within the tetrameric fraction of PolyHbBv in guinea pig. Oxygen equilibrium curves of PolyHbBv measured in plasma after ET were more left-shifted in guinea pigs compared with rats, consistent with increased ferric PolyHbBv formation. Renal hypoxia-inducible factor (HIF)-1alpha, whose activity strictly depends on the partial pressure of oxygen increased over time, and it correlated inversely with circulating ferrous PolyHbBv in both species. Interestingly, HIF-1alpha activity was greater in guinea pigs compared with rats at 72 h post-ET. Mean arterial pressure increases were also greater in guinea pigs; however, minimal differences in cardiac and renal pathology were observed in either species. The present findings suggest the importance of plasma AA in maintaining the stability of acellular Hb susceptible to oxidation, and they may be relevant to humans, which display a similar plasma/tissue antioxidant status to guinea pig.
JF  - The Journal of pharmacology and experimental therapeutics
AU  - Buehler, Paul W
AU  - D'Agnillo, Felice
AU  - Hoffman, Victoria
AU  - Alayash, Abdu I
AD  - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. paul.buehler@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 49
EP  - 60
VL  - 323
IS  - 1
SN  - 0022-3565, 0022-3565
KW  - Blood Substitutes
KW  - 0
KW  - Hemoglobins
KW  - Hypoxia-Inducible Factor 1, alpha Subunit
KW  - polyhemoglobin
KW  - Ascorbic Acid
KW  - PQ6CK8PD0R
KW  - Oxygen
KW  - S88TT14065
KW  - Index Medicus
KW  - Animals
KW  - Drug Stability
KW  - Kidney -- pathology
KW  - Guinea Pigs
KW  - Myocardium -- pathology
KW  - Kidney -- drug effects
KW  - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
KW  - Rats
KW  - Oxidation-Reduction
KW  - Rats, Sprague-Dawley
KW  - Cattle
KW  - Heart Rate -- drug effects
KW  - Blood Pressure -- drug effects
KW  - Male
KW  - Cell-Free System
KW  - Hemoglobins -- pharmacokinetics
KW  - Blood Substitutes -- pharmacokinetics
KW  - Hemoglobins -- toxicity
KW  - Blood Substitutes -- pharmacology
KW  - Oxygen -- blood
KW  - Plasma Exchange
KW  - Hemoglobins -- pharmacology
KW  - Ascorbic Acid -- blood
KW  - Blood Substitutes -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-05
N1  - Date created - 2007-09-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The utility of a rodent model in detecting pediatric drug-induced nephrotoxicity.
AN  - 68293315; 17636248
AB  - A multi-age rat model was used to identify potential age-related differences in renal injury following exposure to gentamicin (GM). In this study, 10-, 25-, 40-, and 80-day-old Sprague-Dawley rats were dosed with GM at 0, 50, or 100 mg kg(-1) body weight per day (mkd) sc for 6 or 14 days. Urine samples were collected up to 72 h after initial dosing. The maximum tolerated dose was lower in 10-day-old rats than for other ages (none survived 11 days of treatment). Eighty-day-old rats given the highest dose showed a diminished rate of growth and an increase in serum creatinine, blood urea nitrogen (BUN), urinary kidney injury molecule-1 (Kim-1), and renal pathology. Ten- and 40-day-old rats given 100 mkd of GM for 6- or 14 days also had increased levels of serum BUN and Cr and renal pathology, whereas only mild renal alterations were found in 25-day-old rats. After 6 days of treatment with 100 mkd GM, significant increases in Havcr-1 (Kim-1) gene expression were detected only in 10- and 80-day-old rats. In urine samples, nuclear magnetic resonance and ultra performance liquid chromatography/mass spectrometry analysis detected changes related to GM efficacy (e.g., hippurate) and increases in metabolites related to antioxidant activity, which was greatest in the 80-day-old rats. The magnitude of the genomic, metabonomic, and serum chemistry changes appeared to correlate with the degree of nephropathy. These findings indicate that an experimental animal model that includes several developmental stages can detect age-related differences in drug-induced organ toxicities and may be a useful predictor of pediatric drug safety in preclinical studies.
JF  - Toxicological sciences : an official journal of the Society of Toxicology
AU  - Espandiari, Parvaneh
AU  - Zhang, Jun
AU  - Rosenzweig, Barry A
AU  - Vaidya, Vishal S
AU  - Sun, Jinchun
AU  - Schnackenberg, Laura
AU  - Herman, Eugene H
AU  - Knapton, Alan
AU  - Bonventre, Joseph V
AU  - Beger, Richard D
AU  - Thompson, Karol L
AU  - Hanig, Joseph
AD  - Center for Drug Evaluation and Research, Silver Spring, Maryland 20993, USA. parvaneh.espandiari@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 637
EP  - 648
VL  - 99
IS  - 2
SN  - 1096-6080, 1096-6080
KW  - Receptors, Tumor Necrosis Factor
KW  - 0
KW  - Spp1 protein, rat
KW  - TWEAK receptor
KW  - Osteopontin
KW  - 106441-73-0
KW  - Index Medicus
KW  - Rats
KW  - Models, Animal
KW  - Mass Spectrometry
KW  - Animals
KW  - Rats, Sprague-Dawley
KW  - Age Factors
KW  - Liver -- drug effects
KW  - Heart -- drug effects
KW  - Osteopontin -- genetics
KW  - Spleen -- drug effects
KW  - Receptors, Tumor Necrosis Factor -- genetics
KW  - Kidney -- pathology
KW  - Pediatrics
KW  - Kidney -- drug effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-29
N1  - Date created - 2007-09-19
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Environ Health Perspect. 2000 Mar;108 Suppl 1:13-21 [10698720]
J Vet Med Sci. 2000 Sep;62(9):971-5 [11039593]
Environ Health Perspect. 2004 Mar;112(4):465-79 [15033597]
Br J Clin Pharmacol. 2001 Jul;52(1):77-83 [11453893]
Pediatrics. 2001 Oct;108(4):1020-4 [11581462]
J Pineal Res. 2002 May;32(4):231-6 [11982792]
Pediatr Med Chir. 2002 Mar-Apr;24(2):150-6 [11987523]
Birth Defects Res B Dev Reprod Toxicol. 2003 Apr;68(2):111-20 [12866702]
Chem Res Toxicol. 2003 Oct;16(10):1207-16 [14565762]
Pol J Pharmacol. 2003 Jul-Aug;55(4):631-7 [14581723]
Environ Health Perspect. 2004 Mar;112(4):488-94 [15033599]
Analyst. 2004 Jun;129(6):535-41 [15152332]
Drug Metab Pharmacokinet. 2004 Jun;19(3):159-70 [15499183]
Eur J Biochem. 1985 Sep 2;151(2):345-50 [2411555]
Lancet. 1987 Jan 3;1(8523):47-8 [2879132]
J Pharmacol Exp Ther. 1992 Feb;260(2):444-9 [1738093]
Antimicrob Agents Chemother. 1993 Jul;37(7):1510-7 [8363384]
Gen Pharmacol. 1995 Nov;26(7):1477-87 [8690234]
J Biol Chem. 1998 Feb 13;273(7):4135-42 [9461608]
J Am Soc Nephrol. 1998 Apr;9(4):710-8 [9555674]
BMJ. 1998 Apr 25;316(7140):1295-8 [9554902]
J Nucl Med. 1998 May;39(5):865-9 [9591590]
Nephrologie. 1998;19(2):49-55 [9592773]
Kidney Int. 1998 Dec;54(6):1817-31 [9853246]
Antimicrob Agents Chemother. 1999 May;43(5):1003-12 [10223907]
Epilepsia. 1999 Jul;40(7):985-91 [10403224]
J Toxicol Environ Health B Crit Rev. 2004 Nov-Dec;7(6):417-35 [15586877]
Br J Clin Pharmacol. 2005 Jun;59(6):670-3 [15948930]
Biomarkers. 2005 Mar-Jun;10(2-3):173-87 [16076731]
Am J Physiol Renal Physiol. 2006 Feb;290(2):F517-29 [16174863]
J Pineal Res. 2006 May;40(4):343-9 [16635022]
Ren Fail. 2006;28(5):435-40 [16825094]
Expert Opin Drug Metab Toxicol. 2006 Feb;2(1):95-101 [16863471]
Expert Opin Drug Metab Toxicol. 2006 Oct;2(5):697-713 [17014390]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Investigation of protein expression in magnetic field-treated human glioma cells.
AN  - 68292419; 17570505
AB  - We previously reported phenotypic changes in human breast cancer cells following low-level magnetic field (MF) exposure. Here proteomic methods were used to investigate the biochemical effect of MF exposure in SF767 human glioma cells. Protein alterations were studied after exposure to 1.2 microTesla (microT) MF [12 milliGauss (mG), 60 Hertz (Hz)] +/- epidermal growth factor (EGF). SF767 cells were exposed for 3 h to sham conditions (<0.2 microT ambient field strength) or 1.2 microT MF (+/-EGF; 10 ng/ml). Solubilized protein fractions (sham; 1.2 microT; sham + EGF; 1.2 microT + EGF) were loaded for electrophoresis by 2D-PAGE and stained using a colloidal Coomassie blue technique to resolve and characterize the proteins. Protein patterns were compared across groups via Student's t-test using PDQUEST software. Cell profiles revealed significant alterations in the spot density of a subset of treated cells. Automated spot excision and processing was performed prior to peptide mass fingerprinting proteins of interest. Fifty-seven proteins from the detectable pool were identified and/or found to differ significantly across treatment groups. The mean abundance of 10 identified proteins was altered following 1.2 microT exposure. In the presence of EGF six proteins were altered after low magnetic field treatment by increasing (4) or decreasing (2) in abundance. The results suggest that the analysis of differentially expressed proteins in SF767 cells may be useful as biomarkers for biological changes caused by exposure to magnetic fields. (c) 2007 Wiley-Liss, Inc.
JF  - Bioelectromagnetics
AU  - Kanitz, M H
AU  - Witzmann, F A
AU  - Lotz, W G
AU  - Conover, D
AU  - Savage, R E
AD  - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998, USA. mhk2@cdc.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 546
EP  - 552
VL  - 28
IS  - 7
SN  - 0197-8462, 0197-8462
KW  - Neoplasm Proteins
KW  - 0
KW  - Index Medicus
KW  - Radiation Dosage
KW  - Electromagnetic Fields
KW  - Humans
KW  - Cell Line, Tumor
KW  - Dose-Response Relationship, Radiation
KW  - Gene Expression Regulation, Neoplastic -- radiation effects
KW  - Glioma -- metabolism
KW  - Neoplasm Proteins -- metabolism
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-06
N1  - Date created - 2007-09-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - GEN
T1  - The Alcohol Dependence Syndrome, 30 years later: a commentary. the 2006 H. David Archibald lecture.
AN  - 68275691; 17680851
AB  - Major classification systems for alcohol use disorders (DSM-IV and ICD-10) contain elements of the 1976 Edwards and Gross formulation of the Alcohol Dependence Syndrome (ADS). However, issues remain about the criteria that identify Alcohol Dependence (AD) as distinct from Alcohol Abuse (AA) in DSM-IV and Harmful Use in ICD-10. These issues, in part, have their roots in changing historical perceptions of alcohol use and its problems. We discuss current diagnostic criteria for AA and AD, collectively called Alcohol Use Disorders (AUDs), in the context of their historical evolution; research progress in understanding alcohol problems, including alcohol dependence; new findings on the severity of AUDs as classified by DSM-IV; and the role of alcohol consumption patterns in future classifications of AUDs.
          This paper is based largely on the 2006 H. David Archibald Lecture. Parts of the original lecture have been modified to reflect more recent findings from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) of the US National Institute on Alcohol Abuse and Alcoholism (NIAAA). The original Edwards and Gross ADS construct is supported by advances in biological and behavioral science over the past 30 years. New findings indicate that DSM-IV AA and AD are not diagnostically distinct entities, but represent a continuum of severity of AUDs. The ADS criteria may best represent one quantifiable dimension of alcohol use problems and this scale can be related to that of the frequency of harmful patterns of drinking.
          The Edwards and Gross ADS criteria can be used as the basis for beginning the development of scalable multi-dimensional criteria for diagnosing AUDs in new initiatives to revise DSM-IV and ICD-10.
JF  - Addiction (Abingdon, England)
AU  - Li, Ting-Kai
AU  - Hewitt, Brenda G
AU  - Grant, Bridget F
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 1522
EP  - 1530
VL  - 102
IS  - 10
KW  - Index Medicus
KW  - Factor Analysis, Statistical
KW  - Reproducibility of Results
KW  - Alcoholism -- epidemiology
KW  - Alcoholism -- diagnosis
KW  - Humans
KW  - Alcoholism -- classification
KW  - Terminology as Topic
KW  - Male
KW  - Female
KW  - Alcohol-Related Disorders -- diagnosis
KW  - Alcohol-Related Disorders -- classification
KW  - International Classification of Diseases
KW  - Alcohol Drinking -- adverse effects
KW  - Alcohol Drinking -- epidemiology
KW  - Diagnostic and Statistical Manual of Mental Disorders
KW  - Alcohol-Related Disorders -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-12
N1  - Date created - 2007-09-14
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
Addiction. 2008 Feb;103(2):179-80 [18199296]
Addiction. 2007 Oct;102(10):1531-2; discussion 1537-8 [17854327]
Addiction. 2007 Oct;102(10):1535-7; discussion 1537-8 [17854331]
Addiction. 2007 Oct;102(10):1534-5; discussion 1537-8 [17854330]
Addiction. 2007 Oct;102(10):1533-4; discussion 1537-8 [17854329]
Addiction. 2007 Oct;102(10):1532-3; discussion 1537-8 [17854328]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - A Qualitative Study of Programs for Parents with Serious Mental Illness and Their Children: Building Practice-Based Evidence
AN  - 57306734; 200916227
AB  - The rationale for the development of effective programs for parents with serious mental illness and their children is compelling. Using qualitative methods and a grounded theory approach with data obtained in site visits, seven existing programs for parents with mental illness and their children in the United States are described and compared across core components: target population, theory and assumptions, funding, community and agency contexts, essential services and intervention strategies, moderators, and outcomes. The diversity across programs is strongly complemented by shared characteristics, the identification of which provides the foundation for future testing and the development of an evidence base. Challenges in program implementation and sustainability are identified. Qualitative methods are useful, particularly when studying existing programs, in taking steps toward building the evidence base for effective programs for parents with serious mental illness and their children. Adapted from the source document.
JF  - The Journal of Behavioral Health Services & Research
AU  - Nicholson, Joanne
AU  - Hinden, Beth R
AU  - Biebel, Kathleen
AU  - Henry, Alexis D
AU  - Katz-Leavy, Judith
AD  - Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 395
EP  - 413
PB  - Lippincott Williams & Wilkins, Philadelphia PA
VL  - 34
IS  - 4
SN  - 1094-3412, 1094-3412
KW  - Mental health services
KW  - Qualitative methods
KW  - Mentally ill parents
KW  - Children
KW  - Service provision
KW  - article
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LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2009-07-06
N1  - Last updated - 2016-09-27
N1  - SubjectsTermNotLitGenreText - Children; Qualitative methods; Mental health services; Service provision; Mentally ill parents
DO  - http://dx.doi.org/10.1007/s11414-007-9063-5
ER  - 



TY  - JOUR
T1  - Drug Use Patterns and Trends in Rural Communities
AN  - 57232737; 200809694
AB  - Context and Purpose: This study examines the prevalence of tobacco, alcohol, and illicit drug use among adolescents and adults in 3 types of counties: 'rural' (nonmetropolitan counties with urban population less than 20,000), 'urbanized nonmetropolitan' (nonmetropolitan counties with urban population 20,000 or higher), and 'metropolitan' (counties in metropolitan areas). Methods: Data from the 2002-2004 National Surveys on Drug Use and Health are used to compare residents of the 3 county types. Descriptive findings and a multivariate model of marijuana use among adolescents are presented by county type. Findings: Past year illicit drug use is generally similar among adolescents in rural, urbanized nonmetropolitan, and metropolitan counties, except that Ecstasy use is higher among youth in metropolitan and urbanized nonmetropolitan counties than rural counties, while rural youth have a higher prevalence of stimulant and methamphetamine use than metropolitan youth. Gender, race/ethnicity, and family income functioned differentially across the 3 county types as predictors of youth marijuana use during the past year. Rural adults had generally lower rates of illicit drug use than metropolitan adults, but adults in rural and urbanized nonmetropolitan areas had higher rates of methamphetamine use than those in metropolitan areas. Rural youth had a higher prevalence of past month use of tobacco and alcohol. Rural adults had higher rates of tobacco use but lower rates of alcohol use. Conclusions: This study dispels the notion that substance abuse is only an urban problem and provides information useful in developing and implementing interventions that consider the unique characteristics of rural residents. Adapted from the source document.
JF  - The Journal of Rural Health
AU  - Gfroerer, Joseph C
AU  - Larson, Sharon L
AU  - Colliver, James D
AD  - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, Md
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 10
EP  - 15
PB  - National Rural Health Association, Kansas City MO
VL  - 23
IS  - s1
SN  - 0890-765X, 0890-765X
KW  - Tobacco
KW  - Young people
KW  - Drug abuse
KW  - Rural communities
KW  - Adolescents
KW  - Prevalence
KW  - article
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LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-05-02
N1  - Last updated - 2016-09-27
N1  - CODEN - JRHEEX
N1  - SubjectsTermNotLitGenreText - Rural communities; Young people; Drug abuse; Prevalence; Tobacco; Adolescents
DO  - http://dx.doi.org/10.1111/j.1748-0361.2007.00118.x
ER  - 



TY  - JOUR
T1  - Rural Populations Are Not Protected From Drug Use and Abuse
AN  - 57232701; 200809692
AB  - The authors provide data and analysis of drug use by geographic region in the U.S., ethnicity, and type of drug.
JF  - The Journal of Rural Health
AU  - Thomas, Yonette F
AU  - Compton, Wilson M
AD  - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, Md
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 1
EP  - 3
PB  - National Rural Health Association, Kansas City MO
VL  - 23
IS  - s1
SN  - 0890-765X, 0890-765X
KW  - Ethnicity
KW  - Rural communities
KW  - Drug abuse
KW  - Substance abuse
KW  - article
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Rural+Populations+Are+Not+Protected+From+Drug+Use+and+Abuse&rft.au=Thomas%2C+Yonette+F%3BCompton%2C+Wilson+M&rft.aulast=Thomas&rft.aufirst=Yonette&rft.date=2007-10-01&rft.volume=23&rft.issue=s1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2007.00116.x
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-05-02
N1  - Last updated - 2016-09-27
N1  - CODEN - JRHEEX
N1  - SubjectsTermNotLitGenreText - Drug abuse; Rural communities; Substance abuse; Ethnicity
DO  - http://dx.doi.org/10.1111/j.1748-0361.2007.00116.x
ER  - 



TY  - JOUR
T1  - Do HMOs Reduce Preventable Hospitalizations for Medicare Beneficiaries?
AN  - 57230897; 200805721
AB  - This study assesses the association of HMO enrollment with preventable hospitalizations among the elderly in four states. Using 2001 hospital discharge abstracts for elderly Medicare enrollees (age 65 and above) residing in four states (New York, Pennsylvania, Florida, and California), from the Healthcare Cost and Utilization Project (HCUP-SID) database of the Agency for Healthcare Research and Quality, we use a multivariate cross-sectional design with patient-level data for each state. Holding other factors such as demographics and illness severity constant, we find that in three out of four states, Medicare HMO patients had lower odds of a preventable admission versus marker admission than Medicare fee-for-service (FFS) patients. Moreover, in the two states with longest tenure and greatest Medicare HMO penetration, California and Florida, the reduction in preventable admissions among Medicare HMO patients was mainly concentrated among more ill patients. These findings add to the evidence that managed care outperforms traditional care among the elderly, rather than simply skimming off the healthiest populations. [Copyright 2007 Sage Publications, Inc.]
JF  - Medical Care Research and Review
AU  - Basu, Jayasree
AU  - Mobley, Lee R
AD  - Agency for Healthcare Research and Quality jayasree.basu@ahrq.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 544
EP  - 567
PB  - Sage Publications, Thousand Oaks CA
VL  - 64
IS  - 5
SN  - 1077-5587, 1077-5587
KW  - Admissions
KW  - Managed care
KW  - Elderly people
KW  - Medicare
KW  - Health maintenance organizations
KW  - Hospitals
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57230897?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=Do+HMOs+Reduce+Preventable+Hospitalizations+for+Medicare+Beneficiaries%3F&rft.au=Basu%2C+Jayasree%3BMobley%2C+Lee+R&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2007-10-01&rft.volume=64&rft.issue=5&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558707301955
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-04-02
N1  - Last updated - 2016-09-27
N1  - CODEN - MCRRFH
N1  - SubjectsTermNotLitGenreText - Elderly people; Managed care; Health maintenance organizations; Hospitals; Admissions; Medicare
DO  - http://dx.doi.org/10.1177/1077558707301955
ER  - 



TY  - JOUR
T1  - Biased Emotional Attention in Post-Traumatic Stress Disorder: A Help As Well As a Hindrance?
AN  - 57212902; 200808713
AB  - Background From a cognitive neuroscience perspective, the emotional attentional bias in post-traumatic stress disorder (PTSD) could be conceptualized either as emotional hyper-responsiveness or as reduced priming of task-relevant representations due to dysfunction in top-down regulatory systems. We investigated these possibilities both with respect to threatening and positive stimuli among traumatized individuals with and without PTSD. Method: Twenty-two patients with PTSD, 21 trauma controls and 20 non- traumatized healthy participants were evaluated on two tasks. For one of these tasks, the affective Stroop task (aST), the emotional stimuli act as distracters and interfere with task performance. For the other, the emotional lexical decision task (eLDT), emotional information facilitates task performance. Results: Compared to trauma controls and healthy participants, patients with PTSD showed increased interference for negative but not positive distracters on the aST and increased emotional facilitation for negative words on the eLDT. Conclusions: These findings document that hyper-responsiveness to threat but not to positive stimuli is specific for patients with PTSD. Adapted from the source document.
JF  - Psychological Medicine
AU  - Vythilingam, M
AU  - Blair, K S
AU  - McCaffrey, D
AU  - Scaramozza, M
AU  - Jones, M
AU  - Nakic, M
AU  - Mondillo, K
AU  - Hadd, K
AU  - Bonne, O
AU  - Mitchell, D G V
AU  - Pine, D S
AU  - Charney, D S
AU  - Blair, R J R
AD  - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 1445
EP  - 1455
PB  - Cambridge University Press, UK
VL  - 37
IS  - 10
SN  - 0033-2917, 0033-2917
KW  - Hypersensitivity
KW  - Posttraumatic stress disorder
KW  - Attentional bias
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57212902?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Biased+Emotional+Attention+in+Post-Traumatic+Stress+Disorder%3A+A+Help+As+Well+As+a+Hindrance%3F&rft.au=Vythilingam%2C+M%3BBlair%2C+K+S%3BMcCaffrey%2C+D%3BScaramozza%2C+M%3BJones%2C+M%3BNakic%2C+M%3BMondillo%2C+K%3BHadd%2C+K%3BBonne%2C+O%3BMitchell%2C+D+G+V%3BPine%2C+D+S%3BCharney%2C+D+S%3BBlair%2C+R+J+R&rft.aulast=Vythilingam&rft.aufirst=M&rft.date=2007-10-01&rft.volume=37&rft.issue=10&rft.spage=1445&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS003329170700092X
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-04-02
N1  - Last updated - 2016-09-27
N1  - CODEN - PSMDCO
N1  - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Attentional bias; Hypersensitivity
DO  - http://dx.doi.org/10.1017/S003329170700092X
ER  - 



TY  - JOUR
T1  - Randomized trial of prize-based reinforcement density for simultaneous abstinence from cocaine and heroin
AN  - 57092654; 200802038
AB  - To examine the effect of reinforcer density in prize-based abstinence reinforcement, heroin/cocaine users (N = 116) in methadone maintenance (100 mg/day) were randomly assigned to a noncontingent control group (NonC) or to 1 of 3 groups that earned prize draws for abstinence: manual drawing with standard prize density (MS) or computerized drawing with standard (CS) or high (CH) density. Probabilities (prizes/draw) were standard (50%) and high (78%); prize density was double blind. Mean prize values were CH, $286; CS, $167; MS, $139; and NonC, $171. Outcomes were % opioid/cocaine-negative urines during the 12-week intervention and then 8 weeks postintervention as well as diagnosis of dependence up to 6 months poststudy. CH had significantly more negative specimens than did NonC during intervention and had more than all groups during postintervention treatment: Mean % negative (95% confidence interval) during postintervention treatment adjusted for baseline drug use and dropout were CH, 55% (14%-90%); CS, 7% (1%-27%); MS, 4% (1%-12%); and NonC, 3% (1%-10%). Current cocaine dependence diagnoses after treatment were significantly lower in contingent compared with noncontingent groups. Computerized drawing with higher-density prizes enhanced reduction of cocaine use; abstinence reinforcement had long-term therapeutic benefits. [Copyright 2007 American Psychological Association]
JF  - Journal of Consulting and Clinical Psychology
AU  - Ghitza, Udi E
AU  - Epstein, David H
AU  - Schmittner, John
AU  - Vahabzadeh, Massoud
AU  - Lin, Jia-Ling
AU  - Preston, Kenzie L
AD  - Treatment Section, Clinical Pharmacology and Therapeutics Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institute of Health (NIH)/Department of Health and Human Services (DHHS), Baltimore, MD, US
Y1  - 2007/10//
PY  - 2007
DA  - October 2007
SP  - 765
EP  - 774
PB  - American Psychological Association, Washington DC
VL  - 75
IS  - 5
SN  - 0022-006X, 0022-006X
KW  - Abstinence
KW  - Heroin
KW  - Interventions
KW  - Reinforcement
KW  - Cocaine
KW  - article
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Randomized+trial+of+prize-based+reinforcement+density+for+simultaneous+abstinence+from+cocaine+and+heroin&rft.au=Ghitza%2C+Udi+E%3BEpstein%2C+David+H%3BSchmittner%2C+John%3BVahabzadeh%2C+Massoud%3BLin%2C+Jia-Ling%3BPreston%2C+Kenzie+L&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2007-10-01&rft.volume=75&rft.issue=5&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-02-04
N1  - Last updated - 2016-09-27
N1  - CODEN - JCLPBC
N1  - SubjectsTermNotLitGenreText - Reinforcement; Abstinence; Cocaine; Heroin; Interventions
ER  - 



TY  - JOUR
T1  - The correlation of youth physical activity with state policies
AN  - 36942577; 3756927
AB  - Childhood overweight has risen dramatically in the United States during the past three decades. The search for policy solutions is limited by a lack of evidence regarding the effectiveness of state policies for increasing physical activity among youths. This paper estimates the correlation of student physical activity with a variety of state policies. We study nationwide data on high school students from the Youth Risk Behavior Surveillance System for 1999, 2001, and 2003 merged with data on state policies from several sources. We control for a variety of characteristics of states and students to mitigate bias due to the endogenous selection of policies, but we conservatively interpret our results as correlations, not causal impacts. Two policies are positively correlated with participation in physical education (PE) class for both boys and girls: a binding PE unit requirement and a state PE curriculum. We also find that state spending on parks and recreation is positively correlated with two measures of girls' overall physical activity. Reprinted by permission of Oxford University Press
JF  - Contemporary economic policy
AU  - Cawley, John
AU  - Meyerhoefer, Chad
AU  - Newhouse, David
AD  - Cornell University ; US Agency for Healthcare Research and Quality ; International Monetary Fund
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 506
EP  - 517
VL  - 25
IS  - 4
SN  - 1074-3529, 1074-3529
KW  - Economics
KW  - Political Science
KW  - Obesity
KW  - Education policy
KW  - Physical activity
KW  - Economics of sport
KW  - Health policy
KW  - U.S.A.
KW  - Students
KW  - Public health
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LA  - English
DB  - International Bibliography of the Social Sciences (IBSS)
N1  - Date revised - 2013-06-12
N1  - Last updated - 2013-09-16
N1  - SubjectsTermNotLitGenreText - 4035 7337 4032 3198 4025; 8823; 10449 5772; 9506; 12334 4049; 5788 11888 10472; 4056 11888 10472; 433 293 14
DO  - http://dx.doi.org/10.1111/j.1465-7287.2007.00070.x
ER  - 



TY  - JOUR
T1  - Sport and public policy
AN  - 36937324; 3756939
JF  - Contemporary economic policy
AU  - Stevenson, Betsey
AU  - Cawley, John
AU  - Meyerhoefer, Chad
AU  - Newhouse, David
AU  - Downward, Paul
AU  - Riordan, Joseph
AU  - Humphreys, Brad R
AU  - Ruseski, Jane E
AU  - Johnson, Bruce K
AU  - Whitehead, John C
AU  - Mason, Daniel S
AU  - Walker, Gordon J
AU  - Coates, Dennis
AU  - Maennig, Wolfgang
AU  - Plessis, Stan du
AU  - Baade, Robert A
AU  - Matheson, Victor A
AU  - Dilger, Alexander
AU  - Frick, Bernd
AU  - Tolsdorf, Frank
AU  - Szymanski, Stefan
AU  - Ross, Stephen F
AU  - Dehring, Carolyn A
AU  - Depken, Craig A
AU  - Ward, Michael R
AU  - Ross, Justin M
AU  - Dunn, Robert R
AD  - University of Pennsylvania ; Cornell University ; US Agency for Healthcare Research and Quality ; International Monetary Fund ; Loughborough University ; University of Hertfordshire ; University of Alberta ; Appalachian State University ; University of Maryland ; Universität Hamburg ; Stellenbosch University ; Lake Forest College ; College of the Holy Cross ; Westfälische Wilhelms-Universität Münster ; Universität Paderborn ; Universität Witten/Herdecke ; Imperial College London ; Penn State University ; University of Georgia ; University of North Carolina, Charlotte ; University of Texas, Arlington ; West Virginia University
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 483
EP  - 655
VL  - 25
IS  - 4
SN  - 1074-3529, 1074-3529
KW  - Economics
KW  - Hurricane Katrina
KW  - World Cup
KW  - Major League Baseball
KW  - Dallas
KW  - New Orleans
KW  - Canada
KW  - Public infrastructure
KW  - Secondary schools
KW  - Regulatory policy
KW  - Physical activity
KW  - Social interaction
KW  - Baseball
KW  - Public management
KW  - Drug abuse
KW  - Sports
KW  - Alberta
KW  - Real estate market
KW  - Project management
KW  - Public health
KW  - Education policy
KW  - Housing prices
KW  - Vertical integration
KW  - Civil rights
KW  - Housing market
KW  - South Africa
KW  - Louisiana
KW  - Regional development
KW  - Public spaces
KW  - Obesity
KW  - Income elasticity
KW  - Economic efficiency
KW  - Economics of sport
KW  - Texas
KW  - U.S.A.
KW  - Students
KW  - Willingness-to-pay
KW  - Natural disasters
KW  - Recreation
KW  - Schools
KW  - Local economy
KW  - Legislation
KW  - Athletes
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contemporary+economic+policy&rft.atitle=Sport+and+public+policy&rft.au=Stevenson%2C+Betsey%3BCawley%2C+John%3BMeyerhoefer%2C+Chad%3BNewhouse%2C+David%3BDownward%2C+Paul%3BRiordan%2C+Joseph%3BHumphreys%2C+Brad+R%3BRuseski%2C+Jane+E%3BJohnson%2C+Bruce+K%3BWhitehead%2C+John+C%3BMason%2C+Daniel+S%3BWalker%2C+Gordon+J%3BCoates%2C+Dennis%3BMaennig%2C+Wolfgang%3BPlessis%2C+Stan+du%3BBaade%2C+Robert+A%3BMatheson%2C+Victor+A%3BDilger%2C+Alexander%3BFrick%2C+Bernd%3BTolsdorf%2C+Frank%3BSzymanski%2C+Stefan%3BRoss%2C+Stephen+F%3BDehring%2C+Carolyn+A%3BDepken%2C+Craig+A%3BWard%2C+Michael+R%3BRoss%2C+Justin+M%3BDunn%2C+Robert+R&rft.aulast=Stevenson&rft.aufirst=Betsey&rft.date=2007-10-01&rft.volume=25&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Contemporary+economic+policy&rft.issn=10743529&rft_id=info:doi/
LA  - English
DB  - International Bibliography of the Social Sciences (IBSS)
N1  - Date revised - 2013-06-12
N1  - SuppNotes - Collection of 12 articles
N1  - Last updated - 2013-09-16
N1  - SubjectsTermNotLitGenreText - 4035 7337 4032 3198 4025; 12132 7336 3198; 11324; 11408 11324; 2309 11032 9705; 4056 11888 10472; 7321; 8823; 10449 5772; 9506; 12334 4049; 11860 11907; 10663 7336 3198; 10486; 13567 13219 13221; 7501 8503; 10453; 10709 3483; 3923; 10326 7625; 8559 3601; 10460 7625; 1365 556; 3742 1121 11776 3753 3755; 13288 6599; 10745 7584 3977 5574 10472; 6065 10107; 6060 7711; 10632 10630 10339; 1493 12132 7336 3198; 6275 6271; 433 293 14; 220 433 293 14; 419 433 293 14; 385 395 2; 7 75 293 14
ER  - 



TY  - JOUR
T1  - Gauge repeatability and reproducibility for accessing variability during dissolution testing: A technical note
AN  - 21127473; 11176475
AB  - Conclusions In this study, the gauge R&R method was used to analyze sources of variability for the paddle apparatus (USP apparatus 2). An initial evaluation of gauge R&R dissolution testing results using the amount dissolved at 30 minutes for a 10-mg prednisone tablet showed no instrument or operator contributions to variability but did highlight some vessel differences within an instrument. Based on this finding, a new mechanical calibration step was developed to improve the performance of the measurement system.
JF  - AAPS PharmSciTech
AU  - Gao, Zongming
AU  - Moore, Terry
AU  - Smith, Anjanette P
AU  - Doub, William
AU  - Westenberger, Benjamin
AU  - Buhse, Lucinda
AD  - Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, 63101 St Louis, MO, Zongming.Gao@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 11
EP  - 15
PB  - Springer New York LLC
VL  - 8
IS  - 4
SN  - 1530-9932, 1530-9932
KW  - Biotechnology and Bioengineering Abstracts
KW  - Prednisone
KW  - Tablets
KW  - Dissolution
KW  - W 30965:Miscellaneous, Reviews
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+PharmSciTech&rft.atitle=Gauge+repeatability+and+reproducibility+for+accessing+variability+during+dissolution+testing%3A+A+technical+note&rft.au=Gao%2C+Zongming%3BMoore%2C+Terry%3BSmith%2C+Anjanette+P%3BDoub%2C+William%3BWestenberger%2C+Benjamin%3BBuhse%2C+Lucinda&rft.aulast=Gao&rft.aufirst=Zongming&rft.date=2007-10-01&rft.volume=8&rft.issue=4&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=AAPS+PharmSciTech&rft.issn=15309932&rft_id=info:doi/10.1208%2Fpt0804082
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-11-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Prednisone; Tablets; Dissolution
DO  - http://dx.doi.org/10.1208/pt0804082
ER  - 



TY  - JOUR
T1  - High prevalence of CTX-M-15 extended-spectrum {szligbeta}-lactamase among contacts of patients with shigellosis due to Shigella flexneri carrying CTX-M-15
AN  - 21122524; 7613404
JF  - Journal of Antimicrobial Chemotherapy
AU  - Upton, Arlo
AU  - Mohiuddin, Jasmine
AU  - Bathgate, Tracy
AU  - Taylor, Susan
AU  - Simmons, Greg
AU  - Woodhouse, Rosemary
AU  - Heffernan, Helen
AD  - Clinical Microbiology, Lab Plus, Auckland City Hospital, Auckland, New Zealand. Population Protection Group, Auckland Regional Public Health Service, Auckland, New Zealand. Clinical Microbiology, Middlemore Hospital, Auckland, New Zealand. Antibiotic Reference Laboratory, Institute of Environmental Science and Research, Wellington, New Zealand
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 906
EP  - 908
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 60
IS  - 4
SN  - 0305-7453, 0305-7453
KW  - Microbiology Abstracts B: Bacteriology
KW  - Shigellosis
KW  - Shigella flexneri
KW  - J 02340:Antibiotics & Antimicrobials
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21122524?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=High+prevalence+of+CTX-M-15+extended-spectrum+%7Bszligbeta%7D-lactamase+among+contacts+of+patients+with+shigellosis+due+to+Shigella+flexneri+carrying+CTX-M-15&rft.au=Upton%2C+Arlo%3BMohiuddin%2C+Jasmine%3BBathgate%2C+Tracy%3BTaylor%2C+Susan%3BSimmons%2C+Greg%3BWoodhouse%2C+Rosemary%3BHeffernan%2C+Helen&rft.aulast=Upton&rft.aufirst=Arlo&rft.date=2007-10-01&rft.volume=60&rft.issue=4&rft.spage=906&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-01-01
N1  - Last updated - 2015-03-31
N1  - SubjectsTermNotLitGenreText - Shigellosis; Shigella flexneri
ER  - 



TY  - JOUR
T1  - Clinical significance of the presence of amniotic fluid sludge in asymptomatic patients at high risk for spontaneous preterm delivery
AN  - 21065728; 8635431
AB  - Objectives To determine the clinical significance of the presence of amniotic fluid (AF) sludge among asymptomatic patients at high risk for spontaneous preterm delivery. Methods This retrospective case-control study included 281 patients with (n = 66) or without (n = 215) AF sludge, who underwent transvaginal ultrasound examination between 13 and 29 completed weeks of gestation. Patients with threatened preterm labor, multiple gestation, fetal anomalies, placenta previa or uterine contractions were excluded. Results The prevalence of AF sludge in the study population was 23.5% (66/281). The rates of spontaneous preterm delivery at < 28 weeks, < 32 weeks, < 35 weeks and < 37 weeks of gestation were 14.7% (29/197), 21.3% (46/216), 28.7% (62/216) and 42.1% (91/216), respectively. Patients with sludge had: (1) a higher rate of spontaneous preterm delivery at < 28 weeks (46.5% (20/43) vs. 5.8% (9/154); P < 0.001), < 32 weeks (55.6% (25/45) vs. 12.3% (21/171); P < 0.001) and < 35 weeks (62.2% (28/45) vs. 19.9% (34/171); P < 0.001); (2) a higher frequency of clinical chorioamnionitis (15.2% (10/66) vs. 5.1% (11/215); P = 0.007), histologic chorioamnionitis (61.5% (40/65) vs. 28% (54/193); P < 0.001) and funisitis (32.3% (21/65) vs. 19.2% (37/193); P = 0.03); (3) a higher frequency of preterm prelabor rupture of membranes (PROM) (39.4% (26/66) vs. 13.5% (29/215); P < 0.001), lower gestational age at preterm PROM (median 24.7 (interquartile range (IQR), 22.3-28.1) weeks vs. 32.3 (IQR, 27.7-34.8) weeks; P < 0.001); and (4) shorter median ultrasound-to-delivery interval (sludge positive 127 days (95% CI, 120-134 days) vs. sludge negative 161 days (95% CI, 153-169 days); P < 0.001) and ultrasound-to-preterm PROM interval (sludge positive 23 days (95% CI, 7-39 days) vs. sludge negative 57 days (95% CI, 38-77 days); P = 0.003) than those without sludge. AF sludge was an independent explanatory variable for the occurrence of spontaneous preterm delivery at < 28 weeks, < 32 weeks and < 35 weeks, preterm PROM, microbial invasion of the amniotic cavity (MIAC) and histologic chorioamnionitis. Moreover, the combination of a cervical length < 25 mm and sludge conferred an odds ratio of 14.8 and 9.9 for spontaneous preterm delivery at < 28 weeks and < 32 weeks, respectively. Conclusions AF sludge is an independent risk factor for spontaneous preterm delivery, preterm PROM, MIAC and histologic chorioamnionitis in asymptomatic patients at high risk for spontaneous preterm delivery. Furthermore, the combination of sludge and a short cervix confers a higher risk for spontaneous preterm delivery at < 28 weeks and < 32 weeks than a short cervix alone.
JF  - Ultrasound in Obstetrics and Gynecology
AU  - Kusanovic, J P
AU  - Espinoza, J
AU  - Romero, R
AU  - Goncalves, L F
AU  - Nien, J K
AU  - Soto, E
AU  - Khalek, N
AU  - Camacho, N
AU  - Hendler, I
AU  - Mittal, P
AU  - Friel, L A
AU  - Gotsch, F
AU  - Erez, O
AU  - Than, N G
AU  - Mazaki-Tovi, S
AU  - Schoen, M L
AU  - Hassan, S S
AD  - Perinatology Research Branch, National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA, nichdprbchiefstaff@mail.nih.gov
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 706
EP  - 714
PB  - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/]
VL  - 30
IS  - 5
SN  - 0960-7692, 0960-7692
KW  - Biotechnology and Bioengineering Abstracts
KW  - Amniotic fluid
KW  - Cavities
KW  - Uterus
KW  - Gestational age
KW  - Gynecology
KW  - Sludges
KW  - Rupture
KW  - Population studies
KW  - Fetuses
KW  - Placenta
KW  - Risk factors
KW  - Chorioamnionitis
KW  - Cervix
KW  - Obstetrics
KW  - Ultrasound
KW  - W 30910:Imaging
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Clinical+significance+of+the+presence+of+amniotic+fluid+sludge+in+asymptomatic+patients+at+high+risk+for+spontaneous+preterm+delivery&rft.au=Kusanovic%2C+J+P%3BEspinoza%2C+J%3BRomero%2C+R%3BGoncalves%2C+L+F%3BNien%2C+J+K%3BSoto%2C+E%3BKhalek%2C+N%3BCamacho%2C+N%3BHendler%2C+I%3BMittal%2C+P%3BFriel%2C+L+A%3BGotsch%2C+F%3BErez%2C+O%3BThan%2C+N+G%3BMazaki-Tovi%2C+S%3BSchoen%2C+M+L%3BHassan%2C+S+S&rft.aulast=Kusanovic&rft.aufirst=J&rft.date=2007-10-01&rft.volume=30&rft.issue=5&rft.spage=706&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.4081
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Sludges; Risk factors; Chorioamnionitis; Ultrasound; Cervix; Amniotic fluid; Cavities; Gestational age; Placenta; Gynecology; Fetuses; Obstetrics; Population studies; Rupture; Uterus
DO  - http://dx.doi.org/10.1002/uog.4081
ER  - 



TY  - RPRT
T1  - A Hispanic Ironworker Dies When He Falls 50 Feet Through a Floor Opening
AN  - 20968649; 11069763
AB  - A 24 year-old Hispanic ironworker died after falling through a floor opening on a building platform. The victim and two co-workers were evaluating a job they were to undertake at a later date when the incident occurred. The platform on which they were standing was approximately 50 feet above the ground. The hole through which the victim fell had a cover, but it was not secured in place. The cover did not have any marking on it to indicate what it was being used for. The victim was wearing fall protective equipment but was not tied off. The CA/FACE investigator determined that, in order to prevent future occurrences, employers, as part of their Injury and Illness Prevention Program (IIPP) should: Ensure that proper procedures are followed when employees are working around elevated floor openings.
JF  - A Hispanic Ironworker Dies When He Falls 50 Feet Through a Floor Opening. [np]. 2007.
AU  - Anonymous
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
PB  - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html]
KW  - Health & Safety Science Abstracts
KW  - Injuries
KW  - prevention
KW  - Protective equipment
KW  - Ethnic groups
KW  - H 11000:Diseases/Injuries/Trauma
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Hispanic+Ironworker+Dies+When+He+Falls+50+Feet+Through+a+Floor+Opening&rft.title=A+Hispanic+Ironworker+Dies+When+He+Falls+50+Feet+Through+a+Floor+Opening&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-10-01
N1  - Last updated - 2011-12-14
ER  - 



TY  - RPRT
T1  - A Hispanic Maintenance Worker Dies after Falling Through a Skylight
AN  - 20968227; 11069762
AB  - A 39-year-old Hispanic maintenance worker died from injuries received after a fail through a skylight. The victim was using a broom to clean the debris off the skylight. As the victim was applying pressure to the broom, the broom handle broke. The victim lost his balance and fell through the skylight cover and opening approximately 17 feet to the floor below. The employer of the victim had no written employee safety or training programs. The CA/FACE investigator determined that, in order to prevent future occurrences, employers should: Develop and implement safe procedures for cleaning skylights. Establish and maintain an injury and Illness Prevention Program (IIPP).
JF  - A Hispanic Maintenance Worker Dies after Falling Through a Skylight. [np]. 2007.
AU  - Anonymous
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
PB  - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html]
KW  - Health & Safety Science Abstracts
KW  - Injuries
KW  - Training
KW  - prevention
KW  - Ethnic groups
KW  - Maintenance
KW  - H 11000:Diseases/Injuries/Trauma
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Hispanic+Maintenance+Worker+Dies+after+Falling+Through+a+Skylight&rft.title=A+Hispanic+Maintenance+Worker+Dies+after+Falling+Through+a+Skylight&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-10-01
N1  - Last updated - 2011-12-14
ER  - 



TY  - JOUR
T1  - Identification of Phenolic Dermal Sensitizers in a Wound Closure Tape
AN  - 20884266; 8403967
AB  - A latex-allergic patient presented with a severe local reaction to a non-latex wound closure bandage following surgery. Extracts of the bandage were analyzed by gas chromatograph-electron impact-mass spectrometry (GC EI-MS) in the total ion monitoring mode. Components were identified by their ion mass fingerprint and elution time as a corresponding standard from the GC column. The chemicals identified were 4,4'-thiobis-(6-tert-butyl-m-cresol) (TBBC), 6-tert-Butyl-m-cresol (BC), 2,4-di-tert-butylphenol (BP) and erucamide (EA). Sensitization potential of these chemicals was evaluated using two quantitative structure-activity relationship (QSAR) programs. The phenol 2,6-di-tert-butyl-4-(hydroxymethyl)phenol (BHP) was also included in the test series. It was initially thought to be present in the bandage but detectable levels could not be confirmed. The potential for TBBC to induce a sensitization response was predicted by both Derek for Windows and TOPKAT 6.2. The potential for BC and BP to induce a sensitization response was predicted by Derek for Windows, but not TOPKAT. BHP and EA were not predicted to be sensitizers by either QSAR program. Local lymph node assay (LLNA) analysis of the chemicals identified TBBC, BP, and BC as potential sensitizers with EC3 values between 0.2 and 4.5%. None of the animals exhibited body weight loss or skin irritation at the concentrations tested. In agreement with the toxicological modeling, BHP did not induce a sensitization response in the LLNA. Following a positive LLNA response, TBBC, BP, and BC were further characterized by phenotypic analysis of the draining lymph nodes. A positive LLNA result coupled with a lack of increase in B220+IgE+ cell and serum IgE characterize these chemicals as Type IV sensitizers. These studies used a multidisciplinary approach combining clinical observation, GC-EI-MS for chemical identification, QSAR modeling of chemicals prior to animal testing, and the LLNA for determination of the sensitization potential of chemicals in a manufactured product.
JF  - Journal of Immunotoxicology
AU  - Myers, L P
AU  - Law, B F
AU  - Fedorowicz, A
AU  - Siegel, P D
AU  - Butterworth, L F
AU  - Anderson, S E
AU  - Sussman, G
AU  - Shapiro, M
AU  - Meade, B J
AU  - Beezhold, D
AD  - National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 303
EP  - 310
PB  - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk]
VL  - 4
IS  - 4
SN  - 1547-691X, 1547-691X
KW  - Toxicology Abstracts; Immunology Abstracts
KW  - X 24310:Pharmaceuticals
KW  - F 06935:Development, Aging & Organ Systems
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunotoxicology&rft.atitle=Identification+of+Phenolic+Dermal+Sensitizers+in+a+Wound+Closure+Tape&rft.au=Myers%2C+L+P%3BLaw%2C+B+F%3BFedorowicz%2C+A%3BSiegel%2C+P+D%3BButterworth%2C+L+F%3BAnderson%2C+S+E%3BSussman%2C+G%3BShapiro%2C+M%3BMeade%2C+B+J%3BBeezhold%2C+D&rft.aulast=Myers&rft.aufirst=L&rft.date=2007-10-01&rft.volume=4&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunotoxicology&rft.issn=1547691X&rft_id=info:doi/10.1080%2F15476910701680236
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-09-01
N1  - Last updated - 2011-12-14
DO  - http://dx.doi.org/10.1080/15476910701680236
ER  - 



TY  - JOUR
T1  - Oxidative stress and antioxidant defenses in goldfish liver in response to short-term exposure to arsenite
AN  - 20837957; 7763418
AB  - Arsenic is an environmental pollutant capable of causing oxidative stress, disturbance of metabolism, and cancer development. The present study was undertaken to investigate the effects of exposure to sodium arsenite on the glutathione pool, lipid peroxidation, protein carbonyl levels, global DNA methylation, and activities of six antioxidant enzymes in goldfish liver. In a preliminary experiment, 7-day exposure to 200 M sodium arsenite, but not 10 or 100 M, disturbed the glutathione status. A detailed investigation of oxidative stress development and antioxidant responses was further examined during different periods of exposure to 200 M sodium arsenite. This treatment increased lipid peroxide levels after 1 and 4 days of exposure but did not affect thiobarbituric acid reactive substances and protein carbonyls. Oxidized glutathione and the oxidative stress index rose after 4 days, but de novo glutathione synthesis decreased both parameters after 7 days. Activities of the main antioxidant enzymes-superoxide dismutase, catalase, and glutathione peroxidase, were elevated after longer periods of exposure, indicating an enhanced antioxidant response. Arsenite exposure led to DNA hypomethylation, which is an early marker of disturbed epigenetic regulations. The findings suggest that goldfish livers cope with arsenic-induced oxidative stress mainly through adaptive changes in the glutathione pool and antioxidant enzymes.
JF  - Environmental and Molecular Mutagenesis
AU  - Bagnyukova, Tetyana V
AU  - Luzhna, Lidia I
AU  - Pogribny, Igor P
AU  - Lushchak, Volodymyr I
AD  - Department of Biochemistry, Precarpathian National University, Ivano-Frankivsk, Ukraine, Tetyana.Bagnyukova@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 658
EP  - 665
PB  - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/]
VL  - 48
IS  - 8
SN  - 0893-6692, 0893-6692
KW  - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Toxicology Abstracts
KW  - thiobarbituric acid
KW  - Arsenic
KW  - Sodium arsenite
KW  - Antioxidants
KW  - Arsenite
KW  - Enzymes
KW  - Carassius auratus
KW  - Cancer
KW  - Catalase
KW  - Lipid peroxidation
KW  - Mutagenesis
KW  - Pollutants
KW  - epigenetics
KW  - Oxidative stress
KW  - Glutathione peroxidase
KW  - DNA methylation
KW  - Liver
KW  - peroxide
KW  - carbonyls
KW  - Metabolism
KW  - N 14820:DNA Metabolism & Structure
KW  - X 24360:Metals
KW  - G 07730:Development & Cell Cycle
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Oxidative+stress+and+antioxidant+defenses+in+goldfish+liver+in+response+to+short-term+exposure+to+arsenite&rft.au=Bagnyukova%2C+Tetyana+V%3BLuzhna%2C+Lidia+I%3BPogribny%2C+Igor+P%3BLushchak%2C+Volodymyr+I&rft.aulast=Bagnyukova&rft.aufirst=Tetyana&rft.date=2007-10-01&rft.volume=48&rft.issue=8&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20328
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - thiobarbituric acid; Arsenic; Antioxidants; Sodium arsenite; Arsenite; Enzymes; Lipid peroxidation; Catalase; Cancer; Mutagenesis; Pollutants; Glutathione peroxidase; Oxidative stress; epigenetics; Liver; DNA methylation; peroxide; carbonyls; Metabolism; Carassius auratus
DO  - http://dx.doi.org/10.1002/em.20328
ER  - 



TY  - JOUR
T1  - 70-P: Immunological long-term evaluation of decellularized versus cryopreserved allografts during ROSS operation
AN  - 20764472; 8177885
JF  - Human Immunology
AU  - Silva, HA
AU  - Glehn, CQC
AU  - Costa, FDA
AU  - Contini-Duarte, D
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 1
PB  - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com]
VL  - 68
IS  - 1
SN  - 0198-8859, 0198-8859
KW  - Biotechnology and Bioengineering Abstracts; Immunology Abstracts
KW  - Transplantation
KW  - Allografts
KW  - Cryopreservation
KW  - W 30945:Fermentation & Cell Culture
KW  - F 06920:Transplantation
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Human+Immunology&rft.atitle=70-P%3A+Immunological+long-term+evaluation+of+decellularized+versus+cryopreserved+allografts+during+ROSS+operation&rft.au=Silva%2C+HA%3BGlehn%2C+CQC%3BCosta%2C+FDA%3BContini-Duarte%2C+D&rft.aulast=Silva&rft.aufirst=HA&rft.date=2007-10-01&rft.volume=68&rft.issue=1&rft.spage=S50&rft.isbn=&rft.btitle=&rft.title=Human+Immunology&rft.issn=01988859&rft_id=info:doi/10.1016%2Fj.humimm.2007.08.093
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-05-01
N1  - SuppNotes - 33rd Ann. ASHI Meeting Abstracts 2007.
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Transplantation; Allografts; Cryopreservation
DO  - http://dx.doi.org/10.1016/j.humimm.2007.08.093
ER  - 



TY  - JOUR
T1  - Book review of Bhuyan, M., Measurement and Control in Food Processing (2007), CRC Press, Taylor & Francis Group, 340 pp.
AN  - 20637793; 7539104
JF  - Food Microbiology
AU  - Schlesser, J
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 804
EP  - 805
PB  - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 24
IS  - 7-8
SN  - 0740-0020, 0740-0020
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - Food processing
KW  - Books
KW  - Reviews
KW  - A 01330:Food Microbiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20637793?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Book+review+of+Bhuyan%2C+M.%2C+Measurement+and+Control+in+Food+Processing+%282007%29%2C+CRC+Press%2C+Taylor+%26amp%3B+Francis+Group%2C+340+pp.&rft.au=Schlesser%2C+J&rft.aulast=Schlesser&rft.aufirst=J&rft.date=2007-10-01&rft.volume=24&rft.issue=7-8&rft.spage=804&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2007.03.007
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2011-12-13
N1  - SubjectsTermNotLitGenreText - Food processing; Reviews; Books
DO  - http://dx.doi.org/10.1016/j.fm.2007.03.007
ER  - 



TY  - JOUR
T1  - An Indoor Environmental Quality Investigation of the Fayette County (Pennsylvania) Courthouse
AN  - 20543819; 8105099
AB  - The National Institute for Occupational Safety and Health (NIOSH) conducted a health hazard evaluation (HHE) investigation in the basement of the Fayette County Courthouse in Uniontown, Pennsylvania. Employees had reported a variety of health complaints including headaches, throat irritation, eye irritation, nausea, fatigue and nasal/sinus symptoms. Potential causes of the complaints included excessive mould/mildew, lack of air flow, odours and high dust levels. A number of locations showing signs of water incursion or leakage were found to have mould growth. The air flow provided by the ventilation systems in most areas was inadequate, although temperature, relative humidity and carbon dioxide levels largely met published recommendations. Levels of common volatile organic compounds were all below established exposure limits, and only toluene was found in concentrations above established odour thresholds.
JF  - Indoor and Built Environment
AU  - Martin, SB Jr
AU  - Coffey, C C
AD  - Department of Health & Human Services, Centers for Disease Control and Prevention, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA, SMartin1@cdc.gov
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 456
EP  - 464
VL  - 16
IS  - 5
SN  - 1420-326X, 1420-326X
KW  - Microbiology Abstracts C: Algology, Mycology & Protozoology; Pollution Abstracts
KW  - Relative humidity
KW  - Odor thresholds
KW  - Pharynx
KW  - Eye
KW  - Ventilation
KW  - Toluene
KW  - Occupational safety
KW  - Threshold limits
KW  - Odors
KW  - fatigue
KW  - Dust
KW  - Air temperature
KW  - air flow
KW  - Headache
KW  - Mildew
KW  - Nausea
KW  - Air flow
KW  - Leakage
KW  - Fatigue
KW  - Temperature
KW  - Humidity
KW  - Sinus
KW  - Irritation
KW  - USA, Pennsylvania
KW  - volatile organic compounds
KW  - Environmental quality
KW  - Carbon dioxide
KW  - Volatile organic compounds
KW  - P 0000:AIR POLLUTION
KW  - K 03420:Plant Diseases
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20543819?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+and+Built+Environment&rft.atitle=An+Indoor+Environmental+Quality+Investigation+of+the+Fayette+County+%28Pennsylvania%29+Courthouse&rft.au=Martin%2C+SB+Jr%3BCoffey%2C+C+C&rft.aulast=Martin&rft.aufirst=SB&rft.date=2007-10-01&rft.volume=16&rft.issue=5&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=Indoor+and+Built+Environment&rft.issn=1420326X&rft_id=info:doi/10.1177%2F1420326X07082791
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Relative humidity; Odor thresholds; Pharynx; Fatigue; Leakage; Ventilation; Eye; Toluene; Threshold limits; Sinus; Air temperature; Irritation; Dust; Headache; volatile organic compounds; Mildew; Environmental quality; Nausea; Carbon dioxide; Air flow; Occupational safety; Temperature; Humidity; Odors; fatigue; air flow; Volatile organic compounds; USA, Pennsylvania
DO  - http://dx.doi.org/10.1177/1420326X07082791
ER  - 



TY  - JOUR
T1  - Baseline behavior, but not sensitivity to stimulant drugs, differs among Spontaneously Hypertensive, Wistar-Kyoto, and Sprague-Dawley rat strains
AN  - 20459286; 7785737
AB  - Deficits in temporal processing are implicated in Attention Deficit Hyperactivity Disorder (ADHD) for which the most common rodent model is the Spontaneously Hypertensive Rat (SHR). To assess strain differences in temporal processing, males and females of the SHR, Wistar-Kyoto (WKY), and Sprague-Dawley (SD) strains were compared on two timing tasks: one requiring maintenance of a lever press for 10-14 s (TRD, temporal response differentiation) and the other requiring withholding of a lever press for 10-14 s (DRL, differential reinforcement of low rates). Performance of the progressive ratio (PR) task more directly assessed food-motivated behavior. Strains did not differ in task acquisition; however, steady state TRD and DRL performance of the SHR and WKY strains was less accurate which was related to increased burst (non-timing related) responses in those strains relative to the SD. PR performance demonstrated that the SHR and WKY strains exhibited higher response rates and breakpoints than the SD. Subsequently, methylphenidate (1, 3.25, 4.50, 7.50, and 12.0 mg/kg) and d-amphetamine (0.1, 0.25, 0.65, 1.0, and 2.0 mg/kg) were administered intraperitoneally pre-testing. Both drugs disrupted TRD and DRL performances by increasing burst response frequency; however, the strains were not differentially sensitive to either drug. Strain differences were generally maintained throughout the drug and extinction portions of the study. These results indicate increased similarity between the SHR and WKY strains relative to the SD in performance of timing and motivation tasks. Further, the current results do not support continued use of the SHR as a model for ADHD.
JF  - Neurotoxicology and Teratology
AU  - Ferguson, SA
AU  - Paule, M G
AU  - Cada, A
AU  - Fogle, C M
AU  - Gray, E P
AU  - Berry, K J
AD  - National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, United States, Sherry.Ferguson@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 547
EP  - 561
PB  - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com]
VL  - 29
IS  - 5
SN  - 0892-0362, 0892-0362
KW  - CSA Neurosciences Abstracts; Toxicology Abstracts
KW  - Motivation
KW  - Extinction
KW  - Temporal variations
KW  - Food
KW  - Attention deficit hyperactivity disorder
KW  - Methylphenidate
KW  - Stimulants
KW  - Models
KW  - Breakpoints
KW  - Differentiation
KW  - Information processing
KW  - Reinforcement
KW  - Amphetamine
KW  - Drugs
KW  - N3 11028:Neuropharmacology & toxicology
KW  - X 24300:Methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Extinction; Motivation; Temporal variations; Food; Attention deficit hyperactivity disorder; Methylphenidate; Stimulants; Models; Differentiation; Breakpoints; Information processing; Reinforcement; Amphetamine; Drugs
DO  - http://dx.doi.org/10.1016/j.ntt.2007.07.001
ER  - 



TY  - JOUR
T1  - Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens: a multicentre study from Korea
AN  - 20331722; 7613390
AB  - OBJECTIVES: To investigate the prevalence of qnr determinants, their influence on quinolone susceptibility and their association with other plasmid-mediated genes in AmpC-producing Enterobacteriaceae without any selection criteria. METHODS: A total of 644 consecutive, non-duplicate isolates of Enterobacter cloacae (186), Enterobacter aerogenes (154), Citrobacter freundii (138) and Serratia marcescens (166) were examined. We performed antimicrobial susceptibility testing and PCR for qnr determinants (qnrA, qnrB and qnrS), extended-spectrum {szligbeta}-lactamase (ESBL) (bla sub(TEM), bla sub(SHV) and bla sub(CTX-M)), orf513, orf1005 and bla sub(DHA-1.) To differentiate qnr subtypes, restriction enzyme analysis and sequencing was performed. RESULTS: The prevalence of qnr determinants was high in C. freundii (38.4%) and E. cloacae (28.5%), but low in E. aerogenes (3.2%) and S. marcescens (2.4%). qnrA1 was most frequent in E. cloacae, and qnrB was prevalent in C. freundii. All the qnrA- and qnrB4-positive isolates showed ciprofloxacin MICs greater than or equal to 0.5 mg/L and nalidixic acid MICs greater than or equal to 16 mg/L. However, the B1 and B2 subtypes showed a wide range of quinolone MICs. In relation to ESBLs, we found that qnrA1, qnrB2 and qnrB4 producers were significantly more frequent among ESBL producers (P < 0.05). Twelve of 13 qnrB4 producers harboured bla sub(DHA-1). orf513 was detected in 43 isolates of the 47 isolates with co-resident qnr and ESBL genes. None of the qnr producers harboured orf1005. CONCLUSIONS: The prevalence of qnrA and qnrB was high among C. freundii and E. cloacae in Korea and there were characteristics unique to the qnr subtypes. Quinolones should be used cautiously in these species, especially when they are ESBL producers.
JF  - Journal of Antimicrobial Chemotherapy
AU  - Park, Yeon-Joon
AU  - Yu, Jin Kyung
AU  - Lee, Seungok
AU  - Oh, Eun-Jee
AU  - Woo, Gun-Jo
AD  - Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary's Hospital, 505 Banpo-dong, Seocho-ku, Seoul 137-701, Korea. Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Holy Family Hospital, Sosa-dong, Wonmi-gu, Bucheon, Kyunggi-do 420-717, Korea. Korea Food and Drug Administration, 231 Jinheungno, Eunpyeong-gu, Seoul 122-704, Korea
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 868
EP  - 871
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 60
IS  - 4
SN  - 0305-7453, 0305-7453
KW  - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology
KW  - Citrobacter freundii
KW  - Quinolones
KW  - Enzymes
KW  - Genetic diversity
KW  - Enterobacter aerogenes
KW  - Minimum inhibitory concentration
KW  - Antimicrobial agents
KW  - Ciprofloxacin
KW  - Enterobacter cloacae
KW  - Nalidixic acid
KW  - Serratia marcescens
KW  - Polymerase chain reaction
KW  - Enterobacteriaceae
KW  - A 01340:Antibiotics & Antimicrobials
KW  - G 07770:Bacteria
KW  - J 02340:Antibiotics & Antimicrobials
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Ciprofloxacin; Quinolones; Nalidixic acid; Genetic diversity; Enzymes; Polymerase chain reaction; Minimum inhibitory concentration; Antimicrobial agents; Enterobacter cloacae; Citrobacter freundii; Serratia marcescens; Enterobacter aerogenes; Enterobacteriaceae
ER  - 



TY  - JOUR
T1  - Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre-exposure to lipopolysaccharide
AN  - 20325013; 7516788
AB  - The oral toxicity of a single administration by gavage (10, 20 or 30 mg kg-1 body weight) of colchicine (COL) was determined in young, mature male and female Sprague-Dawley rats. The effect of COL was evaluated in the presence or absence of additional treatment variables that included vehicle and lipopolysaccharide (LPS) pre-exposure. The vehicle for COL was either Half and Half cream (H & H) or saline, and each group included pretreatment with either saline or a low, minimally toxic dose (83 µg kg-1 body weight) of LPS. Colchicine toxicity in both male and female age-matched rats was characterized by progressively more severe dose-related clinical signs of toxicity. These included mortality, decreased body weight and feed intake during the first several days after dosing, with recovery thereafter in surviving animals. There were differences in the severity of the toxic response to COL between male and female rats. The most notable sex-related difference was in COL lethality. Female rats were two times more susceptible to the lethal effects of COL than male rats. Saline or H & H delivery vehicles did not result in any apparent qualitative or quantitative differences in COL toxicity. LPS pretreatment significantly potentiated COL lethality in both males and females, although the potentiation in males was greater than in females. LPS pretreatment modestly increased the COL induced anorexic effect in surviving males, but not in surviving female animals. LPS did not appear to modulate either the body weights or clinical signs of COL induced toxicity in surviving males or females.
JF  - Journal of Applied Toxicology
AU  - Wiesenfeld, Paddy L
AU  - Garthoff, Larry H
AU  - Sobotka, Thomas J
AU  - Suagee, Jessica K
AU  - Barton, Curtis N
AD  - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, Neurotoxicity and In Vitro Toxicology Branch, Laurel, MD, USA, paddy.wiesenfeld@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 421
EP  - 433
PB  - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/]
VL  - 27
IS  - 5
SN  - 0260-437X, 0260-437X
KW  - Toxicology Abstracts
KW  - Mortality
KW  - Lethality
KW  - Body weight
KW  - Potentiation
KW  - Cream
KW  - Lipopolysaccharides
KW  - Colchicine
KW  - Toxicity
KW  - Sex differences
KW  - X 24310:Pharmaceuticals
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Acute+oral+toxicity+of+colchicine+in+rats%3A+effects+of+gender%2C+vehicle+matrix+and+pre-exposure+to+lipopolysaccharide&rft.au=Wiesenfeld%2C+Paddy+L%3BGarthoff%2C+Larry+H%3BSobotka%2C+Thomas+J%3BSuagee%2C+Jessica+K%3BBarton%2C+Curtis+N&rft.aulast=Wiesenfeld&rft.aufirst=Paddy&rft.date=2007-10-01&rft.volume=27&rft.issue=5&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.1198
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-08-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Mortality; Lethality; Body weight; Potentiation; Cream; Lipopolysaccharides; Colchicine; Toxicity; Sex differences
DO  - http://dx.doi.org/10.1002/jat.1198
ER  - 



TY  - JOUR
T1  - Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells
AN  - 20318566; 7610207
AB  - Nuclear factor of activated T cell (NFAT)-3 is a member of the transcription factor NFAT family, which has been demonstrated to be responsible for the up-regulation of the pro-inflammatory cytokine tumor necrosis factor (TNF) in the immune system. Our most recent studies have also shown that TNF is able to induce cell transformation in mouse epidermal Cl41 cells by induction of cyclooxygenase-2 (COX-2) expression. To provide direct evidence for NFAT3 in the environmental carcinogen-caused carcinogenic effect, ( plus or minus )-benzo[a]pyrene-7,8-diol-9,10-epoxide (B[a]PDE), an ultimate environmental carcinogen metabolized from benzo[a]pyrene, was utilized. We found that exposure of Cl41 cells to B[a]PDE was able to induce cell transformation in Cl41 cells, while specific knock-down of NFAT3 resulted in the dramatic inhibition of this cell transformation. The tumorigenicity of B[a]PDE-caused transformed cells was confirmed in nude mice, whereas the tumor formation of B[a]PDE-treated NFAT3 small interference RNA (siRNA) knock-down cells was significantly reduced. Further studies showed that the role of NFAT3 in B[a]PDE-caused cell transformation was mediated by up-regulation of its downstream targeted gene TNF. This conclusion was based on the findings that inhibition of NFAT3 activation by either FK506 or NFAT3 siRNA dramatically down-regulated the TNF induction upon B[a]PDE exposure, and that knock-down of TNF by its specific siRNA also led to abrogation of B[a]PDE-induced cell transformation in Cl41 cells and their tumorigenicity in nude mice. Collectively, these results provide direct evidence for the important role of NFAT3 activation in B[a]PDE-induced cell transformation by up-regulation of TNF expression in mouse epidermal Cl41 cells, further suggesting that B[a]PDE may exert its tumor promotion effect on skin carcinogenesis, at least partially, by inducing TNF expression.
JF  - Carcinogenesis
AU  - Ouyang, Weiming
AU  - Hu, Yu
AU  - Li, Jingxia
AU  - Ding, Min
AU  - Lu, Yongju
AU  - Zhang, Dongyun
AU  - Yan, Yan
AU  - Song, Lun
AU  - Qu, Qingshan
AU  - Desai, Dhimant
AU  - Amin, Shantu
AU  - Huang, Chuanshu
AD  - Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA. Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Department of Pharmacology, School of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 2218
EP  - 2226
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 28
IS  - 10
SN  - 0143-3334, 0143-3334
KW  - Toxicology Abstracts
KW  - Cyclooxygenase-2
KW  - Transformation
KW  - Skin
KW  - Tumor necrosis factor
KW  - Immune system
KW  - Tumorigenesis
KW  - Transformed cells
KW  - Tumorigenicity
KW  - Carcinogens
KW  - Tacrolimus
KW  - Cell activation
KW  - Inflammation
KW  - siRNA
KW  - Transcription factors
KW  - Carcinogenesis
KW  - RNA-mediated interference
KW  - Cytokines
KW  - Benzo(a)pyrene
KW  - NF-AT protein
KW  - X 24350:Industrial Chemicals
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Direct+evidence+for+the+critical+role+of+NFAT3+in+benzo%5Ba%5Dpyrene+diol-epoxide-induced+cell+transformation+through+mediation+of+inflammatory+cytokine+TNF+induction+in+mouse+epidermal+Cl41+cells&rft.au=Ouyang%2C+Weiming%3BHu%2C+Yu%3BLi%2C+Jingxia%3BDing%2C+Min%3BLu%2C+Yongju%3BZhang%2C+Dongyun%3BYan%2C+Yan%3BSong%2C+Lun%3BQu%2C+Qingshan%3BDesai%2C+Dhimant%3BAmin%2C+Shantu%3BHuang%2C+Chuanshu&rft.aulast=Ouyang&rft.aufirst=Weiming&rft.date=2007-10-01&rft.volume=28&rft.issue=10&rft.spage=2218&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Transformation; Cyclooxygenase-2; Skin; Immune system; Tumor necrosis factor; Transformed cells; Tumorigenesis; Tumorigenicity; Tacrolimus; Carcinogens; Inflammation; Cell activation; siRNA; Transcription factors; Carcinogenesis; Cytokines; RNA-mediated interference; Benzo(a)pyrene; NF-AT protein
ER  - 



TY  - JOUR
T1  - A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis
AN  - 20312457; 7617498
AB  - Conventional diagnostic tests for tuberculosis have several limitations and are often unhelpful in establishing the diagnosis of extrapulmonary tuberculosis. Although commercial serological antibody based tests are available, their usefulness in the diagnosis of extrapulmonary tuberculosis is unknown. A systematic review was conducted to assess the accuracy of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis. In a comprehensive search, 21 studies that reported data on sensitivity and specificity for extrapulmonary tuberculosis were identified. These studies evaluated seven different commercial tests, with Anda-TB IgG accounting for 48% of the studies. The results showed that (1) all commercial tests provided highly variable estimates of sensitivity (range 0.00-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (2) the Anda-TB IgG kit showed highly variable sensitivity (range 0.26-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (3) for all tests combined, sensitivity estimates for both lymph node tuberculosis (range 0.23-1.00) and pleural tuberculosis (range 0.26-0.59) were poor and inconsistent; and (4) there were no data to determine the accuracy of the tests in children or in patients with HIV infection, the two groups for which the test would be most useful. At present, commercial antibody detection tests for extrapulmonary tuberculosis have no role in clinical care or case detection.
JF  - Thorax
AU  - Steingart, Karen R
AU  - Henry, Megan
AU  - Laal, Suman
AU  - Hopewell, Philip C
AU  - Ramsay, Andrew
AU  - Menzies, Dick
AU  - Cunningham, Jane
AU  - Weldingh, Karin
AU  - Pai, Madhukar
AD  - Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, and Francis J Curry National Tuberculosis Center, San Francisco, California, USA. County of Sacramento Department of Health and Human Services, Sacramento, California, USA. Veterans Affairs Medical Center and Departments of Pathology and Microbiology, New York University School of Medicine, New York, USA. UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland. Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada. Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen S, Denmark
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 911
EP  - 918
PB  - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK
VL  - 62
IS  - 10
SN  - 0040-6376, 0040-6376
KW  - HIV
KW  - Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW  - Human immunodeficiency virus
KW  - Immunoglobulin G
KW  - Tuberculosis
KW  - Infection
KW  - Children
KW  - Lymph nodes
KW  - J 02350:Immunology
KW  - F 06910:Microorganisms & Parasites
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thorax&rft.atitle=A+systematic+review+of+commercial+serological+antibody+detection+tests+for+the+diagnosis+of+extrapulmonary+tuberculosis&rft.au=Steingart%2C+Karen+R%3BHenry%2C+Megan%3BLaal%2C+Suman%3BHopewell%2C+Philip+C%3BRamsay%2C+Andrew%3BMenzies%2C+Dick%3BCunningham%2C+Jane%3BWeldingh%2C+Karin%3BPai%2C+Madhukar&rft.aulast=Steingart&rft.aufirst=Karen&rft.date=2007-10-01&rft.volume=62&rft.issue=10&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Thorax&rft.issn=00406376&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Immunoglobulin G; Tuberculosis; Children; Infection; Lymph nodes; Human immunodeficiency virus
ER  - 



TY  - JOUR
T1  - Limits of longitudinal decline for the interpretation of annual changes in FEV sub(1) in individuals
AN  - 20309371; 7616406
AB  - OBJECTIVE: Spirometry-based screening programmes often conduct annual assessment of longitudinal changes in forced expiratory volume in 1 second (FEV sub(1)) to identify individuals with excessive rates of decline. Both the American Thoracic Society (ATS) and the American College of Occupational and Environmental Medicine (ACOEM) recommend a reference limit value of greater than or equal to 15% for excessive annual decline. Neither the ATS nor the ACOEM adjust this limit for the precision of the existing spirometry data. The authors propose an improved method of defining the reference limit of longitudinal annual FEV sub(1) decline (LLD) based on the precision of the spirometry data. METHOD: The authors used data from four monitoring programmes and measured their data precision using a pair-wise within-person variation statistic. They then derived programme- and gender-specific absolute and relative LLD values and validated these against the 95th percentiles for observed yearly changes in FEV sub(1). RESULTS: The relative limit for annual decline was more practical than the absolute limit as it adjusted for gender differences in the magnitude of FEV sub(1). The programme-specific relative limit values were in good agreement with 95th percentiles for year-to-year FEV sub(1) changes and ranged from 6.6% to 15.8%. For individuals with COPD and bronchial hyperreactivity the 95th percentiles for year-to-year changes were about 15% and higher. CONCLUSIONS: The relative longitudinal limit for annual FEV sub(1) decline based upon precision of measurements is valid and can be generalised to different gender and population groups. A relative limit of approximately 10% appears appropriate for good quality workplace monitoring programmes, whereas a limit of about 15% appears appropriate for clinical evaluation of individuals with an obstructive airway disease. Computer software based on the method described is available from the corresponding author.
JF  - Occupational and Environmental Medicine
AU  - Hnizdo, Eva
AU  - Sircar, Kanta
AU  - Yan, Tieliang
AU  - Harber, Philip
AU  - Fleming, James
AU  - Glindmeyer, Henry W
AD  - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA Constella Group, Morgantown, WV, USA Division of Occupational and Environmental Medicine, Department of Family Medicine, University of California Los Angeles, Los Angeles, CA, USA Phoenix Fire Department, Phoenix, AZ, USA Section of Pulmonary, Critical Care, and Environmental Medicine, Department of Medicine, Tulane Medical School, New Orleans, LA, USA
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 701
EP  - 707
PB  - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK
VL  - 64
IS  - 10
SN  - 1351-0711, 1351-0711
KW  - Health & Safety Science Abstracts
KW  - Computer programs
KW  - Gender
KW  - Occupational exposure
KW  - Occupational health
KW  - H 1000:Occupational Safety and Health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Computer programs; Gender; Occupational exposure; Occupational health
ER  - 



TY  - JOUR
T1  - Mortality among shipyard Coast Guard workers: a retrospective cohort study
AN  - 20306037; 7616398
AB  - BACKGROUND: The mortality experience of 4702 (4413 men and 289 women) civilian workers in a US Coast Guard shipyard was evaluated. METHODS: All workers employed at the shipyard between 1 January 1950 and 31 December 1964 were included in the study and were followed through 31 December 2001 for vital status. Detailed shipyard and lifetime work histories found in the shipyard personnel records and job descriptions were evaluated. Workers were classified as likely exposed to any potential hazardous substances. In addition, 20 job groups were created on likely similar exposures. Standardised mortality ratios (SMRs) were calculated based on the general population of the state and adjusted for age, calendar period, sex and race. RESULTS: The follow-up was successful for 93.3% of the workers. Among all men employed in the shipyard, there was an excess of mortality from all causes of death (SMR 1.08; 95% CI 1.04 to 1.12), respiratory cancers (SMR 1.29; 95% CI 1.15 to 1.43), lung cancer (SMR 1.26; 95% CI 1.12 to 1.41), mesothelioma (SMR 5.07; 95% CI 1.85 to 11.03) and emphysema (SMR 1.44; 95% CI 1.01 to 1.99) and a decrease for cardiovascular diseases (OR 0.95; 95% CI 0.90 to 1.00), vascular lesions of the central nervous system (SMR 0.80; 95% CI 0.67 to 0.96), cirrhosis of the liver (SMR 0.38; 95% CI 0.25 to 0.57) and external causes of death (SMR 0.55; 95% CI 0.44 to 0.68). A similar pattern was observed for the men classified as exposed. No increasing trend of mortality was found with duration of employment in the shipyard, with the exception of mesothelioma (SMRs of 4.23 and 6.27 for <10 years and greater than or equal to 10 years, respectively). In occupations with at least three cases and with an SMR of greater than or equal to 1.3, the authors observed a significantly elevated mortality for lung cancer among machinists (SMR 1.60; 95% CI 1.08 to 2.29) and shipfitters, welders and cutters (SMR 1.34; 95% CI 1.07 to 1.65) and for oral and nasopharyngeal cancers among wood workers (SMR 6.20; 95% CI 2.27 to 13.50). CONCLUSION: Employment in this Coast Guard shipyard revealed a small but significant excess mortality from all causes, lung cancer and mesothelioma, most of which is probably related to asbestos exposure.
JF  - Occupational and Environmental Medicine
AU  - Krstev, S
AU  - Stewart, P
AU  - Rusiecki, J
AU  - Blair, A
AD  - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland, USA Clinical Center of Serbia, Institute of Occupational and Radiological Health, Belgrade, Serbia and Montenegro Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 651
EP  - 658
PB  - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK
VL  - 64
IS  - 10
SN  - 1351-0711, 1351-0711
KW  - Coast Guard
KW  - Health & Safety Science Abstracts
KW  - Historical account
KW  - Central nervous system
KW  - Mortality
KW  - Asbestos
KW  - Wood
KW  - Cancer
KW  - Liver
KW  - Lesions
KW  - mesothelioma
KW  - Cardiovascular diseases
KW  - Military
KW  - Occupational exposure
KW  - Lung cancer
KW  - H 1000:Occupational Safety and Health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Mortality; Central nervous system; Historical account; Asbestos; Wood; Cancer; Liver; mesothelioma; Lesions; Cardiovascular diseases; Military; Occupational exposure; Lung cancer
ER  - 



TY  - JOUR
T1  - Development and evaluation of an ELISA for quantification of human alpha-1-proteinase inhibitor in complex biological mixtures
AN  - 20250018; 7785784
AB  - Human alpha-1-proteinase inhibitor ( alpha sub(1)-PI) is the most abundant serine protease inhibitor in plasma. Its major function is inhibition of neutrophil elastase in lungs. alpha sub(1)-PI deficiency may result in severe, ultimately fatal emphysema. Three plasma-derived (pd-) alpha sub(1)-PI products are licensed in the US for replacement therapy of deficient patients. The recombinant versions (r- alpha sub(1)-PI), proposed as alternatives to pd- alpha sub(1)-PI products, have been under intensive investigation. For accurate determination of alpha sub(1)-PI from different sources and in various forms, there is an obvious need for reliable standardized assays for alpha sub(1)-PI quantification and potency measurements. As a part of our multi-step research focused on alpha sub(1)-PI structure-function investigation, we have established a simple and reproducible double-sandwich ELISA based on commercially available polyclonal antibodies. The developed ELISA allows the quantification of both pd- alpha sub(1)-PI and r- alpha sub(1)-PI in various complex matrices. A validation of the ELISA was performed with the working range of the assay (3.1-50ng/ml) established on the bases of the following parameters: linearity (3-100ng/ml, r super(2)=0.995); accuracy (87.3-114.6% recovery); intra-assay precision (%CV, 2.8%); inter-assay plate-to-plate precision (3.9% per day and 4.1% day-to-day); detection limit (1.10ng/ml); and quantification limit (3.34ng/ml). The analytical performance of the alpha sub(1)-PI ELISA indicates that this assay can be used for monitoring concentration levels of alpha sub(1)-PI in multi-component biological matrices, based on the following: (a) quantification of r- alpha sub(1)-PI in various fermentation mixtures (E. coli and A. niger); (b) investigation of alpha sub(1)-PI enzymatically digested in the conditions of harsh fungal proteolysis; (c) evaluation of thermally polymerized alpha sub(1)-PI; (d) quantification of alpha sub(1)-PI in human serum; and (e) comparative quantification of alpha sub(1)-PI in commercially available products.
JF  - Biologicals
AU  - Karnaukhova, E
AU  - Golding, B
AU  - Ophir, Y
AD  - Center for Biologics Evaluation and Research, United States Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA, elena.karnaukhova@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 285
EP  - 295
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 35
IS  - 4
SN  - 1045-1056, 1045-1056
KW  - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts
KW  - Proteolysis
KW  - Emphysema
KW  - Enzyme-linked immunosorbent assay
KW  - Antibodies
KW  - Serine proteinase
KW  - Fermentation
KW  - Lung
KW  - Elastase
KW  - Escherichia coli
KW  - Leukocytes (neutrophilic)
KW  - K 03300:Methods
KW  - F 06900:Methods
KW  - W 30915:Pharmaceuticals & Vaccines
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biologicals&rft.atitle=Development+and+evaluation+of+an+ELISA+for+quantification+of+human+alpha-1-proteinase+inhibitor+in+complex+biological+mixtures&rft.au=Karnaukhova%2C+E%3BGolding%2C+B%3BOphir%2C+Y&rft.aulast=Karnaukhova&rft.aufirst=E&rft.date=2007-10-01&rft.volume=35&rft.issue=4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Biologicals&rft.issn=10451056&rft_id=info:doi/10.1016%2Fj.biologicals.2006.11.002
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Proteolysis; Emphysema; Antibodies; Enzyme-linked immunosorbent assay; Serine proteinase; Lung; Fermentation; Elastase; Leukocytes (neutrophilic); Escherichia coli
DO  - http://dx.doi.org/10.1016/j.biologicals.2006.11.002
ER  - 



TY  - JOUR
T1  - Optimising piperacillin/tazobactam dosing in paediatrics
AN  - 20200457; 7584876
AB  - Piperacillin/tazobactam, an intravenous antibacterial combination product, has recently been approved for paediatric (age 2 months to 17 years) use in the USA. The purpose of this analysis is to describe the basis for the dosing recommendations in this age group. Pharmacokinetic (PK) parameters and demographic covariates from 53 children enrolled in two paediatric studies were used in the analysis. Individual drug clearance (CL) values calculated by non-compartmental methods were available. The influence of demographic covariates on CL was investigated by non-linear regression. The analysis identified CL to be dependent on body weight. CL was also found to be influenced by age in paediatric patients =9 months, a dose of 100/12.5mg/kg every 8h showed exposures similar to adults; for paediatric patients aged 2-9 months, the dose of 100/12.5mg/kg should be reduced by a factor of 0.8 (i.e. 80/10mg/kg), likely due to immature renal function. Based upon this analysis, dosing recommendations for paediatric patients down to 2 months of age were incorporated in the labelling. No data were available to allow additional recommendations for paediatric patients <2 months of age to be made.
JF  - International Journal of Antimicrobial Agents
AU  - Tornoe, Christoffer W
AU  - Tworzyanski, Jeffrey J
AU  - Imoisili, Menfo A
AU  - Alexander, John J
AU  - Korth-Bradley, Joan M
AU  - Gobburu, Jogarao V S
AD  - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA, christoffer.tornoe@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 320
EP  - 324
PB  - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 30
IS  - 4
SN  - 0924-8579, 0924-8579
KW  - Microbiology Abstracts B: Bacteriology
KW  - Paediatric dosing
KW  - Anti-infectives
KW  - Pharmacometric analysis
KW  - Age
KW  - Intravenous administration
KW  - Data processing
KW  - Pediatrics
KW  - Tazobactam
KW  - Children
KW  - Pharmacokinetics
KW  - Demography
KW  - Renal function
KW  - Body weight
KW  - Piperacillin
KW  - Drugs
KW  - J 02340:Antibiotics & Antimicrobials
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-08-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Demography; Intravenous administration; Age; Data processing; Body weight; Renal function; Pediatrics; Piperacillin; Tazobactam; Children; Drugs; Pharmacokinetics
DO  - http://dx.doi.org/10.1016/j.ijantimicag.2007.05.014
ER  - 



TY  - JOUR
T1  - Traffic exposure and lung function in adults: the Atherosclerosis Risk in Communities study
AN  - 20166841; 7617491
AB  - BACKGROUND: Traffic exposure is a major contributor to ambient air pollution for people living close to busy roads. The relationship between traffic exposure and lung function remains inconclusive in adults. METHODS: A cross-sectional study was conducted to investigate the association between traffic exposure and lung function in the Atherosclerosis Risk in Communities (ARIC) study, a community based cohort of 15 792 middle aged men and women. Traffic density and distance to major roads were used as measures of traffic exposure. RESULTS: After controlling for potential confounders including demographic factors, personal and neighbourhood level socioeconomic characteristics, cigarette smoking and background air pollution, higher traffic density was significantly associated with lower forced expiratory volume in 1 s (FEV sub(1)) and forced vital capacity (FVC) in women. Relative to the lowest quartile of traffic density, the adjusted differences across increasing quartiles were 5.1, -15.4 and -21.5 ml for FEV sub(1) (p value of linear trend across the quartiles = 0.041) and 1.2, -23.4 and -34.8 ml for FVC (p trend = 0.010). Using distance from major roads as a simpler index of traffic related air pollution exposure, the FEV sub(1) was -15.7 ml (95% CI -34.4 to 2.9) lower and the FVC was -24.2 ml (95% CI -46.2 to -2.3) lower for women living within 150 m compared with subjects living further away. There was no significant effect of traffic density or distance to major roads on lung function in men. The FEV sub(1)/FVC ratio was not significantly associated with traffic exposure in either men or women. CONCLUSIONS: This is the largest published study of traffic exposure and pulmonary function in adults to date. These results add to growing evidence that chronic exposure to traffic related air pollution may adversely affect respiratory health.
JF  - Thorax
AU  - Kan, Haidong
AU  - Heiss, Gerardo
AU  - Rose, Kathryn M
AU  - Whitsel, Eric
AU  - Lurmann, Fred
AU  - London, Stephanie J
AD  - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, North Carolina, USA. Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, North Carolina, USA. Sonoma Technology Inc, Petaluma, California, USA
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 873
EP  - 879
PB  - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK
VL  - 62
IS  - 10
SN  - 0040-6376, 0040-6376
KW  - Pollution Abstracts; Toxicology Abstracts
KW  - demography
KW  - Socioeconomics
KW  - Arteriosclerosis
KW  - community involvement
KW  - Traffic
KW  - Air pollution
KW  - Demography
KW  - Socio-economic aspects
KW  - traffic
KW  - Lung
KW  - Chronic exposure
KW  - Cigarette smoking
KW  - Respiratory function
KW  - P 0000:AIR POLLUTION
KW  - X 24490:Other
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thorax&rft.atitle=Traffic+exposure+and+lung+function+in+adults%3A+the+Atherosclerosis+Risk+in+Communities+study&rft.au=Kan%2C+Haidong%3BHeiss%2C+Gerardo%3BRose%2C+Kathryn+M%3BWhitsel%2C+Eric%3BLurmann%2C+Fred%3BLondon%2C+Stephanie+J&rft.aulast=Kan&rft.aufirst=Haidong&rft.date=2007-10-01&rft.volume=62&rft.issue=10&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=Thorax&rft.issn=00406376&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Demography; Air pollution; Socio-economic aspects; Chronic exposure; Lung; Cigarette smoking; Arteriosclerosis; Traffic; demography; traffic; Socioeconomics; Respiratory function; community involvement
ER  - 



TY  - JOUR
T1  - Two Cases of Uveal Amelanotic Melanoma in Transgenic Tyr-HRAS+ Ink4a/Arf Heterozygous Mice
AN  - 19884450; 7692106
AB  - Uveal melanoma (UM) is uncommon among wild type mice. Efforts to develop transgenic mice to study this disease have resulted in pigmented tumors derived from the retinal pigment epithelium (RPE) or mixed tumors of RPE and UM complicating the study of UM specifically. Reported here are two early stage intraocular amelanotic melanomas discovered in 2 Tyr-HRAS+ Ink4a/Arf heterozygous (1 normal CKDN2A allele) transgenic FVB/n mice. These tumors were morphologically and immunohistochemically similar to spontaneous UM recently reported in the Ink4a/Arf homozygous (CKDN2A knockout) parent strain. The tumors originated in the posterior uveal tract. The neoplasms were comprised of bundles of spindle-shaped melanocytes admixed with some epithelioid cells. Tumors were immunohistochemically positive for neuron-specific enolase, S-100, pan-ras, but negative for cytokeratin and Melan-A. The development of early lenticular opacity and bilateral cataracts is a consistent phenotype of transgenic mice in which the retinoblastoma signaling pathway has been disrupted. Lenticular opacity and cataracts are rarely observed clinically in Tyr-HRAS+ Ink4a/Arf heterozygotes, rendering this strain suitable for ophthalmoscopy. Consequently, Tyr-HRAS+ Ink4a/Arf heterozygotes provide practical advantages, compared to the cataract-prone CKDN2A knockout strains, for real-time ophthalomoscopic detection and monitoring of UM while developing chemotherapeutic regimens and other research to understand the biology of UM.
JF  - Toxicologic Pathology
AU  - Latendresse, John R
AU  - Muskhelishvili, Levan
AU  - Warbritton, Alan
AU  - Tolleson, William H
AD  - Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, Arkansas, USA
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 825
EP  - 830
PB  - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk]
VL  - 35
IS  - 6
SN  - 0192-6233, 0192-6233
KW  - Biotechnology and Bioengineering Abstracts
KW  - cyclin-dependent kinase inhibitors
KW  - Cataracts
KW  - Melanocytes
KW  - Tumors
KW  - Transgenic mice
KW  - retinoblastoma
KW  - Melanoma
KW  - retinal pigment epithelium
KW  - Heterozygotes
KW  - Phosphopyruvate hydratase
KW  - Signal transduction
KW  - Cytokeratin
KW  - INK4 protein
KW  - W 30925:Genetic Engineering
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Two+Cases+of+Uveal+Amelanotic+Melanoma+in+Transgenic+Tyr-HRAS%2B+Ink4a%2FArf+Heterozygous+Mice&rft.au=Latendresse%2C+John+R%3BMuskhelishvili%2C+Levan%3BWarbritton%2C+Alan%3BTolleson%2C+William+H&rft.aulast=Latendresse&rft.aufirst=John&rft.date=2007-10-01&rft.volume=35&rft.issue=6&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1080%2F01926230701584221
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-05-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - cyclin-dependent kinase inhibitors; Cataracts; Tumors; Melanocytes; Transgenic mice; Melanoma; retinoblastoma; retinal pigment epithelium; Heterozygotes; Phosphopyruvate hydratase; INK4 protein; Cytokeratin; Signal transduction
DO  - http://dx.doi.org/10.1080/01926230701584221
ER  - 



TY  - JOUR
T1  - On the use of the T-RExTM tetracycline-inducible gene expression system in vivo
AN  - 19872604; 7586557
AB  - Components of the commercially available T-RExTM system were used to create two types of transgenic mice. The first contained the tetracycline-repressor transgene under the control of the CMV promoter/enhancer; the second type contained a green fluorescent protein (GFP) reporter transgene under the control of the CMV promoter/enhancer with a tetracycline repressor operator sequence. Transgene expression was unpredictable in animals containing the individual transgenes. Animals with the reporter transgene expressed GFP in only some tissues (e.g., pancreas, kidney), and one line of reporter transgenic animals developed kidney disease, presumably due to expression of the transgene. The two types of transgenic animals were crossbred to produce double-transgenic animals with the object of regulating the expression of the reporter in vivo. When a similar double-transgenic system was constructed in cultured cells, the repressor protein suppressed the transcription of the reporter transgene. The presence of the repressor in double-transgenic animals had no effect on the expression of the reporter; double transgenic animals developed the same kidney disease that was seen in singly transgenic mice with the reporter. Our results indicate that transgenes under the control of the CMV promoter in the T-REx system express somewhat unpredictably and in only a limited number of tissues, making the use of this system for the development of in vivo models problematical. Biotechnol. Bioeng. 2007; 98:719-723.
JF  - Biotechnology and Bioengineering
AU  - Dobrovolsky, Vasily N
AU  - Heflich, Robert H
AD  - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, HFT-120, Jefferson, Arkansas 72079, vasily.dobrovolsky@fda.hhs.gov
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 719
EP  - 723
PB  - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/]
VL  - 98
IS  - 3
SN  - 0006-3592, 0006-3592
KW  - Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW  - Pancreas
KW  - Kidney diseases
KW  - Animal models
KW  - Green fluorescent protein
KW  - Transcription
KW  - Transgenic mice
KW  - Tetracyclines
KW  - Cytomegalovirus
KW  - Gene expression
KW  - Operators
KW  - Promoters
KW  - Enhancers
KW  - Repressors
KW  - G 07730:Development & Cell Cycle
KW  - W 30920:Tissue Engineering
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Operators; Gene expression; Enhancers; Promoters; Pancreas; Green fluorescent protein; Animal models; Kidney diseases; Transcription; Tetracyclines; Transgenic mice; Repressors; Cytomegalovirus
DO  - http://dx.doi.org/10.1002/bit.21454
ER  - 



TY  - JOUR
T1  - Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer
AN  - 19790572; 7930188
AB  - Polymorphisms in the human genome contribute to wide variations in how individuals respond to medications, either by changing the pharmacokinetics of drugs or by altering the cellular response to therapeutic agents. The goal of the emerging discipline of pharmacogenomics is to personalize therapy based on an individual's genotype. Due to the relatively large frequency of single-nucleotide polymorphisms (SNP) in the human genome, synonymous SNPs are often disregarded in many pharmacogenomic studies based on the assumption that these are silent. We have shown recently that synonymous SNPs in ABCB1 (P-glycoprotein), which is implicated both in determining drug pharmacokinetics and multidrug resistance in human cancer cells, can affect protein conformation and function. We discuss the importance of polymorphisms in drug metabolizing enzymes and transporters in anticancer therapy and suggest that synonymous polymorphisms may play a more significant role than is currently assumed. [Cancer Res 2007; 67(20):9609-12]
JF  - Cancer Research
AU  - Sauna, Zuben E
AU  - Kimchi-Sarfaty, Chava
AU  - Ambudkar, Suresh V
AU  - Gottesman, Michael M
AD  - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH and Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 9609
EP  - 9612
PB  - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/]
VL  - 67
IS  - 20
SN  - 0008-5472, 0008-5472
KW  - Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW  - Genomes
KW  - Protein structure
KW  - P-Glycoprotein
KW  - Single-nucleotide polymorphism
KW  - pharmacogenomics
KW  - Enzymes
KW  - Multidrug resistance
KW  - Cancer
KW  - Pharmacokinetics
KW  - G 07880:Human Genetics
KW  - W 30940:Products
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-02-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Protein structure; Genomes; P-Glycoprotein; pharmacogenomics; Single-nucleotide polymorphism; Enzymes; Multidrug resistance; Pharmacokinetics; Cancer
ER  - 



TY  - JOUR
T1  - Polymorphisms in Apoptosis- and Proliferation-Related Genes, Ionizing Radiation Exposure, and Risk of Breast Cancer among U.S. Radiologic Technologists
AN  - 19789544; 7610307
AB  - Background: Although genes involved in apoptosis pathways and DNA repair pathways are both essential for maintaining genomic integrity, genetic variants in DNA repair have been thought to increase susceptibility to radiation carcinogenesis, but similar hypotheses have not generally been raised about apoptosis genes. For this reason, potential modification of the relationship between ionizing radiation exposure and breast cancer risk by polymorphic apoptosis gene variants have not been investigated among radiation-exposed women. Methods: In a case-control study of 859 cases and 1,083 controls within the U.S. Radiologic Technologists cohort, we assessed breast cancer risk with respect to 16 candidate variants in eight genes involved in apoptosis, inflammation, and proliferation. Using carefully reconstructed cumulative breast dose estimates from occupational and personal diagnostic ionizing radiation, we also investigated the joint effects of these polymorphisms on the risk of breast cancer. Results: In multivariate analyses, we observed a significantly decreased risk of breast cancer associated with the homozygous minor allele of CASP8 D302H [rs1045485, odds ratio (OR), 0.3; 95% confidence interval (95% CI), 0.1-0.8]. We found a significantly increased breast cancer risk with increasing minor alleles for IL1A A114S (rs17561); heterozygote OR 1.2 (95% CI, 1.0-1.4) and homozygote OR 1.5 (95% CI, 1.1-2.0), P sub(trend) = 0.008. Assuming a dominant genetic model, IL1A A114S significantly modified the dose-response relationship between cumulative personal diagnostic radiation and breast cancer risk, adjusted for occupational dose (P sub(interaction) = 0.004). Conclusion: The U.S. Radiologic Technologists breast cancer study provided a unique opportunity to examine the joint effects of common genetic variation and ionizing radiation exposure to the breast using detailed occupational and personal diagnostic dose data. We found evidence of effect modification of the radiation and breast cancer dose-response relationship that should be confirmed in studies with more cases and controls and quantified radiation breast doses in the low-to-moderate range. (Cancer Epidemiol Biomarkers Prev 2007; 16(10):2000-7)
JF  - Cancer Epidemiology, Biomarkers & Prevention
AU  - Sigurdson, Alice J
AU  - Bhatti, Parveen
AU  - Doody, Michele M
AU  - Hauptmann, Michael
AU  - Bowen, Laura
AU  - Simon, Steven L
AU  - Weinstock, Robert M
AU  - Linet, Martha S
AU  - Rosenstein, Marvin
AU  - Stovall, Marilyn
AU  - Alexander, Bruce H
AU  - Preston, Dale L
AU  - Struewing, Jeffrey P
AU  - Rajaraman, Preetha
AD  - Radiation Epidemiology Branch and Biostatistics Branch, Division of Cancer Epidemiology and Genetics, and Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services
Y1  - 2007/10//
PY  - 2007
DA  - Oct 2007
SP  - 2000
EP  - 2007
PB  - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/]
VL  - 16
IS  - 10
SN  - 1055-9965, 1055-9965
KW  - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts
KW  - Apoptosis
KW  - Gene polymorphism
KW  - Interleukin 1
KW  - Joint diseases
KW  - Genetic diversity
KW  - Homozygotes
KW  - Models
KW  - Multivariate analysis
KW  - Dose-response effects
KW  - prevention
KW  - genomics
KW  - occupational exposure
KW  - Occupational exposure
KW  - Bioindicators
KW  - Data processing
KW  - genetic diversity
KW  - DNA repair
KW  - biomarkers
KW  - Cancer
KW  - Inflammation
KW  - USA
KW  - Ionizing radiation
KW  - Carcinogenesis
KW  - Heterozygotes
KW  - DNA
KW  - Breast cancer
KW  - X 24390:Radioactive Materials
KW  - R2 23080:Industrial and labor
KW  - N 14820:DNA Metabolism & Structure
KW  - G 07710:Chemical Mutagenesis & Radiation
KW  - H 1000:Occupational Safety and Health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Data processing; Apoptosis; Gene polymorphism; Interleukin 1; Joint diseases; Genetic diversity; DNA repair; biomarkers; Homozygotes; Inflammation; Models; Multivariate analysis; Ionizing radiation; Dose-response effects; Heterozygotes; Carcinogenesis; Breast cancer; genomics; Occupational exposure; Bioindicators; prevention; DNA; genetic diversity; occupational exposure; Cancer; USA
ER  - 



TY  - JOUR
T1  - Glycosylation of the dengue 2 virus E protein at N67 is critical for virus growth in vitro but not for growth in intrathoracically inoculated Aedes aegypti mosquitoes.
AN  - 68285611; 17543367
AB  - To determine the importance of dengue 2 virus (DEN2V) envelope (E) protein glycosylation, virus mutants in one or both of the N-linked glycosylation motifs were prepared. We found that while the E2 mutant virus (N153Q) replicated in mammalian and mosquito cells, the E1 (N67Q) and E1/2 (N67Q and N153Q) mutant viruses were unable to grow in mammalian cells. Infection of C6/36 mosquito cells with either the E1 or E1/2 mutants resulted in the introduction of a compensatory mutation, K64N, restoring glycosylation in the area. All mutants replicated similarly in inoculated Aedes aegypti mosquitoes, with no change in their mutations. These results suggest that N-linked glycosylation of the E protein is not necessary for DEN2V replication in mosquitoes, however N-linked glycosylation at amino acid N67 (or nearby N64) is critical for the survival of the virus in either mammalian or insect cell culture.
JF  - Virology
AU  - Bryant, Juliet E
AU  - Calvert, Amanda E
AU  - Mesesan, Kyeen
AU  - Crabtree, Mary B
AU  - Volpe, Katharine E
AU  - Silengo, Shawn
AU  - Kinney, Richard M
AU  - Huang, Claire Y-H
AU  - Miller, Barry R
AU  - Roehrig, John T
AD  - Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Fort Collins, CO 80522, USA.
Y1  - 2007/09/30/
PY  - 2007
DA  - 2007 Sep 30
SP  - 415
EP  - 423
VL  - 366
IS  - 2
SN  - 0042-6822, 0042-6822
KW  - E-glycoprotein, Dengue virus type 2
KW  - 0
KW  - Viral Envelope Proteins
KW  - Index Medicus
KW  - Mutagenesis, Site-Directed
KW  - Animals
KW  - Amino Acid Substitution -- genetics
KW  - Humans
KW  - Glycosylation
KW  - Cell Line
KW  - Dengue Virus -- growth & development
KW  - Aedes -- virology
KW  - Viral Envelope Proteins -- metabolism
KW  - Dengue Virus -- genetics
KW  - Viral Envelope Proteins -- genetics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-30
N1  - Date created - 2007-09-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Bortezomib for the treatment of mantle cell lymphoma.
AN  - 68282766; 17875757
AB  - To describe the Food and Drug Administration review and marketing approval considerations for bortezomib (Velcade) for the treatment of patients with mantle cell lymphoma.
          Food and Drug Administration reviewed a multicenter study of bortezomib in 155 patients with progressive mantle cell lymphoma after at least one prior therapy. Seventy-seven percent were stage IV, and 75% had one or more extranodal sites of disease. Prior therapy included an anthracycline or mitoxantrone, cyclophosphamide, and rituximab. Median age was 65 years. All received bortezomib 1.3 mg/m(2) i.v. on days 1, 4, 8, and 11 of each 3-week cycle. The primary end point was response. Response and progression were determined by independent review of serial computed tomography scans using International Lymphoma Workshop Response Criteria. The overall response rate was 31%, including complete response (CR) plus CR unconfirmed (CRu) plus partial response; median response duration was 9.3 months. The CR plus CRu response rate was 8% with a median duration of 15.4 months. Adverse events were similar to those observed previously for bortezomib. The most commonly reported treatment-emergent adverse events were asthenia (72%), peripheral neuropathies (55%), constipation (50%), diarrhea (47%), nausea (44%), and anorexia (39%). The most common adverse event leading to discontinuation was neuropathy.
          Bortezomib received regular approval for the treatment of patients with mantle cell lymphoma in relapse after prior therapy.
JF  - Clinical cancer research : an official journal of the American Association for Cancer Research
AU  - Kane, Robert C
AU  - Dagher, Ramzi
AU  - Farrell, Ann
AU  - Ko, Chia-Wen
AU  - Sridhara, Rajeshwari
AU  - Justice, Robert
AU  - Pazdur, Richard
AD  - Division of Drug Oncology Products, Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. robert.kane@fda.hhs.gov
Y1  - 2007/09/15/
PY  - 2007
DA  - 2007 Sep 15
SP  - 5291
EP  - 5294
VL  - 13
IS  - 18 Pt 1
SN  - 1078-0432, 1078-0432
KW  - Antineoplastic Agents
KW  - 0
KW  - Boronic Acids
KW  - Pyrazines
KW  - Bortezomib
KW  - 69G8BD63PP
KW  - Index Medicus
KW  - United States
KW  - United States Food and Drug Administration
KW  - Prospective Studies
KW  - Humans
KW  - Drug Approval
KW  - Aged
KW  - Male
KW  - Female
KW  - Pyrazines -- therapeutic use
KW  - Lymphoma, Mantle-Cell -- drug therapy
KW  - Boronic Acids -- adverse effects
KW  - Antineoplastic Agents -- therapeutic use
KW  - Boronic Acids -- therapeutic use
KW  - Pyrazines -- adverse effects
KW  - Antineoplastic Agents -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-14
N1  - Date created - 2007-09-18
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats
AN  - 20352007; 7611060
AB  - Many welders have experienced bronchitis, metal fume fever, lung function changes, and an increase in the incidence of lung infection. Questions remain regarding the possible mechanisms associated with the potential pulmonary effects of welding fume exposure. The objective was to assess the early effects of stainless steel (SS) welding fume inhalation on lung injury, inflammation, and defense responses. Male Sprague-Dawley rats were exposed to gas metal arc-SS welding fume at a concentration of 15 or 40 mg/m super(3)x3 h/day for 1, 3, or 10 days. The control group was exposed to filtered air. To assess lung defense responses, some animals were intratracheally inoculated with 5x10 super(4)Listeria monocytogenes 1 day after the last exposure. Welding particles were collected during exposure, and elemental composition and particle size were determined. At 1, 4, 6, 11, 14, and 30 days after the final exposure, parameters of lung injury (lactate dehydrogenase and albumin) and inflammation (PMN influx) were measured in the bronchoalveolar lavage fluid. In addition, particle-induced effects on pulmonary clearance of bacteria and macrophage function were assessed. SS particles were composed of Fe, Cr, Mn, and Ni. Particle size distribution analysis indicated the mass median aerodynamic diameter of the generated fume to be 0.255 mu m. Parameters of lung injury were significantly elevated at all time points post-exposure compared to controls except for 30 days. Interestingly, no significant difference in lung PMNs was observed between the SS and control groups at 1, 4, and 6 days post-exposure. After 6 days post-exposure, a dramatic increase in lung PMNs was observed in the SS group compared to air controls. Lung bacteria clearance and macrophage function were reduced and immune and inflammatory cytokines were altered in the SS group. In summary, short-term exposure of rats to SS welding fume caused significant lung damage and suppressed lung defense responses to bacterial infection, but had a delayed effect on pulmonary inflammation. Additional chronic inhalation studies are needed to further examine the lung effects associated with SS welding fume exposure.
JF  - Toxicology and Applied Pharmacology
AU  - Antonini, J M
AU  - Stone, S
AU  - Roberts, J R
AU  - Chen, B
AU  - Schwegler-Berry, D
AU  - Afshari, A A
AU  - Frazer, D G
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA, jga6@cdc.gov
Y1  - 2007/09/15/
PY  - 2007
DA  - 2007 Sep 15
SP  - 234
EP  - 245
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 223
IS  - 3
SN  - 0041-008X, 0041-008X
KW  - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Immunology Abstracts
KW  - Macrophages
KW  - Inhalation
KW  - Metals
KW  - Fumes
KW  - Injuries
KW  - Chromium
KW  - Infection
KW  - Alveoli
KW  - L-Lactate dehydrogenase
KW  - Inflammation
KW  - Fever
KW  - Bronchus
KW  - Lung
KW  - Albumin
KW  - Cytokines
KW  - Welding
KW  - Bronchitis
KW  - Manganese
KW  - Size distribution
KW  - stainless steel
KW  - F 06955:Immunomodulation & Immunopharmacology
KW  - J 02320:Cell Biology
KW  - X 24350:Industrial Chemicals
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Inhalation; Macrophages; Metals; Fumes; Chromium; Injuries; Infection; Alveoli; Inflammation; L-Lactate dehydrogenase; Fever; Bronchus; Lung; Albumin; Welding; Cytokines; Bronchitis; Manganese; Size distribution; stainless steel
DO  - http://dx.doi.org/10.1016/j.taap.2007.06.020
ER  - 



TY  - JOUR
T1  - Human papillomavirus and cervical cancer.
AN  - 68249069; 17826171
AB  - Cervical cancer is the second most common cancer in women worldwide, and knowledge regarding its cause and pathogenesis is expanding rapidly. Persistent infection with one of about 15 genotypes of carcinogenic human papillomavirus (HPV) causes almost all cases. There are four major steps in cervical cancer development: infection of metaplastic epithelium at the cervical transformation zone, viral persistence, progression of persistently infected epithelium to cervical precancer, and invasion through the basement membrane of the epithelium. Infection is extremely common in young women in their first decade of sexual activity. Persistent infections and precancer are established, typically within 5-10 years, from less than 10% of new infections. Invasive cancer arises over many years, even decades, in a minority of women with precancer, with a peak or plateau in risk at about 35-55 years of age. Each genotype of HPV acts as an independent infection, with differing carcinogenic risks linked to evolutionary species. Our understanding has led to improved prevention and clinical management strategies, including improved screening tests and vaccines. The new HPV-oriented model of cervical carcinogenesis should gradually replace older morphological models based only on cytology and histology. If applied wisely, HPV-related technology can minimise the incidence of cervical cancer, and the morbidity and mortality it causes, even in low-resource settings.
JF  - Lancet (London, England)
AU  - Schiffman, Mark
AU  - Castle, Philip E
AU  - Jeronimo, Jose
AU  - Rodriguez, Ana C
AU  - Wacholder, Sholom
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. schiffmm@mail.nih.gov
Y1  - 2007/09/08/
PY  - 2007
DA  - 2007 Sep 08
SP  - 890
EP  - 907
VL  - 370
IS  - 9590
KW  - Papillomavirus Vaccines
KW  - 0
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Humans
KW  - Adult
KW  - Female
KW  - Uterine Cervical Neoplasms -- prevention & control
KW  - Human papillomavirus 16 -- pathogenicity
KW  - Carcinoma, Squamous Cell -- etiology
KW  - Carcinoma, Squamous Cell -- pathology
KW  - Uterine Cervical Neoplasms -- mortality
KW  - Papillomavirus Infections -- complications
KW  - Papillomavirus Vaccines -- therapeutic use
KW  - Human papillomavirus 16 -- genetics
KW  - Papillomavirus Vaccines -- adverse effects
KW  - Uterine Cervical Neoplasms -- virology
KW  - Papillomavirus Infections -- immunology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Human+papillomavirus+and+cervical+cancer.&rft.au=Schiffman%2C+Mark%3BCastle%2C+Philip+E%3BJeronimo%2C+Jose%3BRodriguez%2C+Ana+C%3BWacholder%2C+Sholom&rft.aulast=Schiffman&rft.aufirst=Mark&rft.date=2007-09-08&rft.volume=370&rft.issue=9590&rft.spage=890&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-20
N1  - Date created - 2007-09-10
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - FDA Perspectives on Validation of Multiplex Proteomic Biomarkers.
T2  - 2007 Conference on Protein Discovery and Development
AN  - 39420182; 4662328
JF  - 2007 Conference on Protein Discovery and Development
AU  - Philip, Reena
Y1  - 2007/09/06/
PY  - 2007
DA  - 2007 Sep 06
KW  - Bioindicators
KW  - FDA
KW  - Proteomics
KW  - Biomarkers
KW  - U 2000:Biological Sciences
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L2  - http://www.gtcbio.com/conference/userAgenda.aspx?id=92
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Offered Paper Detection and Characterisation of Cryptosporidium sp. Seeing the Whole Picture through Evidence Based Methodology
T2  - 61st Meeting of the Society for General Microbiology (SGM 2007)
AN  - 39512509; 4674888
JF  - 61st Meeting of the Society for General Microbiology (SGM 2007)
AU  - Elwin, K
Y1  - 2007/09/03/
PY  - 2007
DA  - 2007 Sep 03
KW  - Pathogens
KW  - Food
KW  - Cryptosporidium
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39512509?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Meeting+of+the+Society+for+General+Microbiology+%28SGM+2007%29&rft.atitle=Offered+Paper+Detection+and+Characterisation+of+Cryptosporidium+sp.+Seeing+the+Whole+Picture+through+Evidence+Based+Methodology&rft.au=Elwin%2C+K&rft.aulast=Elwin&rft.aufirst=K&rft.date=2007-09-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Meeting+of+the+Society+for+General+Microbiology+%28SGM+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.socgenmicrobiol.org.uk/meetings/MTGPAGES/Edinburgh07.cfm
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - A population-based job exposure matrix for power-frequency magnetic fields.
AN  - 70749419; 17654227
AB  - A population-based job exposure matrix (JEM) was developed to assess personal exposures to power-frequency magnetic fields (MF) for epidemiologic studies. The JEM compiled 2,317 MF measurements taken on or near workers by 10 studies in the United States, Sweden, New Zealand, Finland, and Italy. A database was assembled from the original data for six studies plus summary statistics grouped by occupation from four other published studies. The job descriptions were coded into the 1980 Standard Occupational Classification system (SOC) and then translated to the 1980 job categories of the U.S. Bureau of the Census (BOC). For each job category, the JEM database calculated the arithmetic mean, standard deviation, geometric mean, and geometric standard deviation of the workday-average MF magnitude from the combined data. Analysis of variance demonstrated that the combining of MF data from the different sources was justified, and that the homogeneity of MF exposures in the SOC occupations was comparable to JEMs for solvents and particulates. BOC occupation accounted for 30% of the MF variance (p << 10(-6)), and the contrast (ratio of the between-job variance to the total of within- and between-job variances) was 88%. Jobs lacking data had their exposures inferred from measurements on similar occupations. The JEM provided MF exposures for 97% of the person-months in a population-based case-control study and 95% of the jobs on death certificates in a registry study covering 22 states. Therefore, we expect this JEM to be useful in other population-based epidemiologic studies.
JF  - Journal of occupational and environmental hygiene
AU  - Bowman, Joseph D
AU  - Touchstone, Jennifer A
AU  - Yost, Michael G
AD  - NIOSH, Engineering and Physical Hazards Branch, Cincinnati, Ohio 45226, USA. jdb0@cdc.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 715
EP  - 728
VL  - 4
IS  - 9
SN  - 1545-9624, 1545-9624
KW  - Index Medicus
KW  - United States
KW  - Finland
KW  - Epidemiologic Methods
KW  - Humans
KW  - Job Description
KW  - Databases, Factual
KW  - Models, Biological
KW  - New Zealand
KW  - Italy
KW  - Sweden
KW  - Electromagnetic Fields
KW  - Occupations
KW  - Occupational Exposure -- analysis
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70749419?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=A+population-based+job+exposure+matrix+for+power-frequency+magnetic+fields.&rft.au=Bowman%2C+Joseph+D%3BTouchstone%2C+Jennifer+A%3BYost%2C+Michael+G&rft.aulast=Bowman&rft.aufirst=Joseph&rft.date=2007-09-01&rft.volume=4&rft.issue=9&rft.spage=715&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-23
N1  - Date created - 2007-07-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Assessment of noise exposure for indoor and outdoor firing ranges.
AN  - 70744371; 17654224
AB  - The National Institute for Occupational Safety and Health (NIOSH) received an employee request for a health hazard evaluation of a Special Weapons Assault Team (SWAT) in January 2002. The department was concerned about noise exposures and potential hearing damage from weapons training on their indoor and outdoor firing ranges. NIOSH investigators conducted noise sampling with an acoustic mannequin head and 1/4 -inch microphone to characterize the noise exposures that officers might experience during small arms qualification and training when wearing a variety of hearing protection devices provided by the department. The peak sound pressure levels for the various weapons ranged from 156 to 170 decibels (dB SPL), which are greater than the recommended allowable 140 dB SPL exposure guideline from NIOSH. The earplugs, ear muffs, and customized SWAT team hearing protectors provided between 25 and 35 dB of peak reduction. Double hearing protection (plugs plus muffs) added 15-20 dB of peak reduction.
JF  - Journal of occupational and environmental hygiene
AU  - Murphy, William J
AU  - Tubbs, Randy L
AD  - Division of Applied Research and Technology, Hearing Loss Prevention Team, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. wmurphy@cdc.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 688
EP  - 697
VL  - 4
IS  - 9
SN  - 1545-9624, 1545-9624
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Hearing Loss, Noise-Induced -- prevention & control
KW  - National Institute for Occupational Safety and Health (U.S.)
KW  - Firearms
KW  - Ear Protective Devices -- standards
KW  - Noise, Occupational
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70744371?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Assessment+of+noise+exposure+for+indoor+and+outdoor+firing+ranges.&rft.au=Murphy%2C+William+J%3BTubbs%2C+Randy+L&rft.aulast=Murphy&rft.aufirst=William&rft.date=2007-09-01&rft.volume=4&rft.issue=9&rft.spage=688&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-23
N1  - Date created - 2007-07-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Concerning sampler wall deposits in the chemical analysis of airborne metals.
AN  - 70712235; 17613720
JF  - Journal of occupational and environmental hygiene
AU  - Harper, Martin
AU  - Demange, Martine
AD  - National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA.
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - D81
EP  - D86
VL  - 4
IS  - 9
SN  - 1545-9624, 1545-9624
KW  - Aerosols
KW  - 0
KW  - Air Pollutants, Occupational
KW  - Metals
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Reference Standards
KW  - National Institute for Occupational Safety and Health (U.S.) -- standards
KW  - United States Occupational Safety and Health Administration -- standards
KW  - Facility Design and Construction
KW  - Ultrafiltration -- methods
KW  - Aerosols -- analysis
KW  - Environmental Monitoring -- legislation & jurisprudence
KW  - Air Pollutants, Occupational -- analysis
KW  - Occupational Exposure -- legislation & jurisprudence
KW  - Occupational Exposure -- analysis
KW  - Metals -- analysis
KW  - Environmental Monitoring -- methods
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70712235?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=A+re-examination+of+distance+as+a+proxy+for+severity+of+illness+and+the+implications+for+differences+in+utilization+by+race%2Fethnicity&rft.au=Basu%2C+Jayasree%3BFriedman%2C+Bernard&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2007-07-01&rft.volume=16&rft.issue=7&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1192
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-23
N1  - Date created - 2007-07-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Determining the spatial variability of personal sampler inlet locations.
AN  - 70710411; 17654226
AB  - This article examines the spatial variability of dust concentrations within a coal miner's breathing zone and the impact of sampling location at the cap lamp, nose, and lapel. Tests were conducted in the National Institute for Safety and Health Pittsburgh Research Laboratory full-scale, continuous miner gallery using three prototype personal dust monitors (PDM). The dust masses detected by the PDMs were used to calculate the percentage difference of dust mass between the cap lamp and the nose and between the lapel and the nose. The calculated percentage differences of the masses ranged from plus 12% to minus 25%. Breathing zone tests were also conducted in four underground coal mines using the torso of a mannequin to simulate a miner. Coal mine dust was sampled with multi-cyclone sampling cans mounted directly in front of the mannequin near the cap lamp, nose, and lapel. These four coal mine tests found that the spatial variability of dust levels and imprecision of the current personal sampler is a greater influence than the sampler location within the breathing zone. However, a one-sample t-test of this data did find that the overall mean value of the cap lamp/nose ratio was not significantly different than 1 (p-value = 0.21). However, when applied to the overall mean value of the lapel/nose ratio there was a significant difference from 1 (p-value < .0001). This finding is important because the lapel has always been the sampling location for coal mine dust samples. But these results suggest that the cap location is slightly more indicative of what is breathed through the nose area.
JF  - Journal of occupational and environmental hygiene
AU  - Vinson, Robert
AU  - Volkwein, Jon
AU  - McWilliams, Linda
AD  - NIOSH, Pittsburgh Research Laboratory, Pittsburgh, Pennsylvania 15236, USA.
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 708
EP  - 714
VL  - 4
IS  - 9
SN  - 1545-9624, 1545-9624
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Coal
KW  - Dust
KW  - Index Medicus
KW  - Dust -- analysis
KW  - Humans
KW  - Manikins
KW  - Coal -- analysis
KW  - Inhalation Exposure -- analysis
KW  - Air Pollutants, Occupational -- analysis
KW  - Coal Mining
KW  - Occupational Exposure -- analysis
KW  - Environmental Monitoring -- instrumentation
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-23
N1  - Date created - 2007-07-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - New respirator fit test panels representing the current U.S. civilian work force.
AN  - 70691398; 17613722
AB  - The fit test panels currently used for respirator research, design, and certification are 25-subject panels developed by Los Alamos National Laboratory (LANL) and are based on data from the 1967 and 1968 anthropometric surveys of U.S. Air Force personnel. Military data do not represent the great diversity in face size and shape seen in civilian populations. In addition, the demographics of the U.S. population have changed over the last 30 years. Thus, it is necessary to assess and refine the LANL fit test panels. This paper presents the development of new respirator fit test panels representative of current U.S. civilian workers based on an anthropometric survey of 3,997 respirator users conducted in 2003. One panel was developed using face length and face width (bivariate approach) and weighting subjects to match the age and race distribution of the U.S. population as determined from the 2000 census. Another panel was developed using the first two principal components obtained from a set of 10 facial dimensions (age and race adjusted). These 10 dimensions are associated with respirator fit and leakage and can predict the remaining face dimensions well. Respirators designed to fit these panels are expected to accommodate more than 95% of the current U.S. civilian workers. Both panels are more representative of the U.S. population than the existing LANL panel and may be appropriate for testing both half-masks and full-face piece respirators. Respirator manufacturers, standards development organizations, and government respirator certification bodies need to select the appropriate fit test panel for their particular needs. The bivariate panel is simpler to use than the principal component analysis (PCA) panel and is most similar to the LANL panel currently used. The inclusion of the eight additional facial measurements allows the PCA panel to provide better criteria for excluding extreme face sizes from being used. Because the boundaries of the two new panels are significantly different from the LANL panel, it may be necessary to develop new respirator sizing systems. A new five-category sizing system is proposed.
JF  - Journal of occupational and environmental hygiene
AU  - Zhuang, Ziqing
AU  - Bradtmiller, Bruce
AU  - Shaffer, Ronald E
AD  - National Institute for Occupational Safety and Health, National Personal ProtectiveTechnology Laboratory, 626 Cochran's Mill Road, Pittsburgh, PA 15236, USA. zaz3@cdc.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 647
EP  - 659
VL  - 4
IS  - 9
SN  - 1545-9624, 1545-9624
KW  - Index Medicus
KW  - United States
KW  - Anthropometry
KW  - Occupational Exposure -- prevention & control
KW  - Inhalation Exposure -- prevention & control
KW  - Humans
KW  - National Institute for Occupational Safety and Health (U.S.)
KW  - Male
KW  - Female
KW  - Face -- anatomy & histology
KW  - Equipment Design -- standards
KW  - Cephalometry
KW  - Respiratory Protective Devices -- standards
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=New+respirator+fit+test+panels+representing+the+current+U.S.+civilian+work+force.&rft.au=Zhuang%2C+Ziqing%3BBradtmiller%2C+Bruce%3BShaffer%2C+Ronald+E&rft.aulast=Zhuang&rft.aufirst=Ziqing&rft.date=2007-09-01&rft.volume=4&rft.issue=9&rft.spage=647&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-23
N1  - Date created - 2007-07-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Ethical and scientific issues of nanotechnology in the workplace.
AN  - 70143533; 18813467
AB  - In the absence of scientific clarity about the potential health effects of occupational exposure to nanoparticles, a need exists for guidance in decision making about hazards, risks, and controls. An identification of the ethical issues involved may be useful to decision makers, particularly employers, workers, investors, and health authorities. Because the goal of occupational safety and health is the prevention of disease in workers, the situations that have ethical implications that most affect workers have been identified. These situations include the a) identification and communication of hazards and risks by scientists, authorities, and employers; b) workers' acceptance of risk; c) selection and implementation of controls; d) establishment of medical screening programs; and e) investment in toxicologic and control research. The ethical issues involve the unbiased determination of hazards and risks, nonmaleficence (doing no harm), autonomy, justice, privacy, and promoting respect for persons. As the ethical issues are identified and explored, options for decision makers can be developed. Additionally, societal deliberations about workplace risks of nanotechnologies may be enhanced by special emphasis on small businesses and adoption of a global perspective.
JF  - Ciencia & saude coletiva
AU  - Schulte, Paul A
AU  - Salamanca-Buentello, Fabio
AD  - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA. pschulte@cdc.gov
PY  - 2007
SP  - 1319
EP  - 1332
VL  - 12
IS  - 5
KW  - Index Medicus
KW  - Humans
KW  - Risk Management
KW  - Workplace
KW  - Safety Management
KW  - Occupational Health
KW  - Nanotechnology -- ethics
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70143533?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ciencia+%26+saude+coletiva&rft.atitle=Ethical+and+scientific+issues+of+nanotechnology+in+the+workplace.&rft.au=Schulte%2C+Paul+A%3BSalamanca-Buentello%2C+Fabio&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2007-09-01&rft.volume=12&rft.issue=5&rft.spage=1319&rft.isbn=&rft.btitle=&rft.title=Ciencia+%26+saude+coletiva&rft.issn=1678-4561&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-12-18
N1  - Date created - 2008-09-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Direct method for determination of Sudan I in FD&C Yellow No. 6 and D&C Orange No. 4 by reversed-phase liquid chromatography.
AN  - 68429174; 17955981
AB  - A reversed-phase liquid chromatographic method was developed to determine parts-per-million and higher levels of Sudan 1, 1-(phenylazo)-2-naphthalenol, in the disulfo monoazo color additive FD&C Yellow No. 6 and in a related monosulfo monoazo color additive, D&C Orange No. 4. Sudan I, the corresponding unsulfonated monoazo dye, is a known impurity in these color additives. The color additives are dissolved in water and methanol, and the filtered solutions are directly chromatographed, without extraction or concentration, by using gradient elution at 0.25 mL/min. Calibrations from peak areas at 485 nm were linear. At a 99% confidence level, the limits of determination were 0.008 microg Sudan I/mL (0.4 ppm) in FD&C Yellow No. 6 and 0.011 microg Sudan I/mL (0.00011%) in D&C Orange No. 4. The confidence intervals were 0.202 +/- 0.002 microg Sudan I/mL (10.1 +/- 0.1 ppm) near the specification level for Sudan I in FD&C Yellow No. 6 and 20.0 +/- 0.2 microg Sudan I/mL (0.200 +/- 0.002%) near the highest concentration of Sudan I found in D&C Orange No. 4. A survey was conducted to determine Sudan I in 28 samples of FD&C Yellow No. 6 from 17 international manufacturers over 3 years, and in a pharmacology-tested sample. These samples were found to contain undetected levels (16 samples), 0.5-9.7 ppm Sudan I (0.01-0.194 microg Sudan I/mL in analyzed solutions; 11 samples including the pharmacology sample), and > or =10 ppm Sudan I (> or = 0.2 microg Sudan I/mL; 2 samples). Analyses of 21 samples of D&C Orange No. 4 from 8 international manufacturers over 4 years found Sudan I at undetected levels (8 samples), 0.0005 to < 0.005% Sudan I (0.05 to < 0.5 microg Sudan I/mL in analyzed solutions; 3 samples, including a pharmacology batch), 0.005 to <0.05% Sudan I (0.5 to <5 microg Sudan I/mL; 9 samples), and 0.18% Sudan I (18 microg Sudan I/mL; 1 sample).
JF  - Journal of AOAC International
AU  - Petigara, Bhakti R
AU  - Scher, Alan L
AD  - U.S. Food and Drug Administration, Office of Cosmetics and Colors, HFS-106, 5100 Paint Branch Pkwy, College Park, MD 20740, USA.
PY  - 2007
SP  - 1373
EP  - 1378
VL  - 90
IS  - 5
SN  - 1060-3271, 1060-3271
KW  - Azo Compounds
KW  - 0
KW  - Naphthols
KW  - C.I. Solvent Orange 2
KW  - 2646-17-5
KW  - 1-phenylazo-2-naphthol
KW  - 48I7IBB68J
KW  - FD & C Yellow No. 6
KW  - H77VEI93A8
KW  - Index Medicus
KW  - Reproducibility of Results
KW  - Spectrophotometry, Ultraviolet -- methods
KW  - Calibration
KW  - Models, Chemical
KW  - Time Factors
KW  - Naphthols -- analysis
KW  - Chromatography, Liquid -- methods
KW  - Technology, Pharmaceutical -- methods
KW  - Azo Compounds -- analysis
KW  - Chemistry, Pharmaceutical -- methods
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68429174?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Direct+method+for+determination+of+Sudan+I+in+FD%26amp%3BC+Yellow+No.+6+and+D%26amp%3BC+Orange+No.+4+by+reversed-phase+liquid+chromatography.&rft.au=Petigara%2C+Bhakti+R%3BScher%2C+Alan+L&rft.aulast=Petigara&rft.aufirst=Bhakti&rft.date=2007-09-01&rft.volume=90&rft.issue=5&rft.spage=1373&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-28
N1  - Date created - 2007-10-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - A second transient prostate-specific antigen elevation after external-beam radiation therapy and fractionated magnetic resonance imaging-guided high-dose rate brachytherapy boost.
AN  - 68426389; 17956716
AB  - A 63-year-old man with a T1c adenocarcinoma of the prostate, Gleason score of 7 (4+3), and a pretreatment prostate-specific antigen (PSA) level of 9.5 ng/mL was treated with external-beam radiation therapy (45 Gy) and 2 magnetic resonance imaging-guided high-dose rate brachytherapy boosts (10 Gy each.) The patient also received neoadjuvant, concurrent, and adjuvant hormonal treatment with leuprolide for 7 months total. Without any further intervention the patient had 2 separate and prolonged PSA increases and decreases 12-35 months after therapy. His PSA nadir was <0.2 ng/mL and rose slowly over several months to 4.2 ng/mL, resolved, and then rose 2.3 ng/mL before again slowly resolving. After prostate irradiation, many patients experience a transient rise in serum PSA levels and a subsequent decline without any treatment. This is known as a PSA "bounce" or "bump." Some patients experience a second transient rise in PSA levels after irradiation. To our knowledge, this case report is the first documentation of a second PSA bump in a patient treated with external-beam radiation therapy and high-dose rate boost therapy and provides context to address concerns and therapeutic decisions confronting physicians and patients.
JF  - Clinical genitourinary cancer
AU  - Mishra, Mark V
AU  - Singh, Anurag K
AD  - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 406
EP  - 408
VL  - 5
IS  - 6
SN  - 1558-7673, 1558-7673
KW  - Antineoplastic Agents, Hormonal
KW  - 0
KW  - Prostate-Specific Antigen
KW  - EC 3.4.21.77
KW  - Leuprolide
KW  - EFY6W0M8TG
KW  - Index Medicus
KW  - Radiotherapy Dosage
KW  - Humans
KW  - Treatment Outcome
KW  - Middle Aged
KW  - Follow-Up Studies
KW  - Antineoplastic Agents, Hormonal -- therapeutic use
KW  - Male
KW  - Magnetic Resonance Imaging
KW  - Adenocarcinoma -- blood
KW  - Radiotherapy, Conformal
KW  - Brachytherapy -- adverse effects
KW  - Prostatic Neoplasms -- blood
KW  - Prostate-Specific Antigen -- blood
KW  - Prostatic Neoplasms -- drug therapy
KW  - Adenocarcinoma -- drug therapy
KW  - Prostatic Neoplasms -- radiotherapy
KW  - Adenocarcinoma -- radiotherapy
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+genitourinary+cancer&rft.atitle=A+second+transient+prostate-specific+antigen+elevation+after+external-beam+radiation+therapy+and+fractionated+magnetic+resonance+imaging-guided+high-dose+rate+brachytherapy+boost.&rft.au=Mishra%2C+Mark+V%3BSingh%2C+Anurag+K&rft.aulast=Mishra&rft.aufirst=Mark&rft.date=2007-09-01&rft.volume=5&rft.issue=6&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Clinical+genitourinary+cancer&rft.issn=15587673&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-03
N1  - Date created - 2007-10-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Thymosin alpha1 as a chemopreventive agent in lung and breast cancer.
AN  - 68406532; 17567944
AB  - The ability of thymosin alpha1 (Talpha1) to prevent lung and breast cancer was investigated. Lung adenomas developed in A/J mice injected with carcinogens, such as urethane. The lung adenoma number was reduced by 15-45% if animals were daily treated subcutaneously (s.c.) with Talpha1 (0.4 mg/kg). Talpha1 (1 microM) directly inhibited the growth of mouse lung cell lines. These results suggest that Talpha1 may prevent mouse lung carcinogenesis because it directly inhibits the growth of lung cancer cells. Talpha1 prevented mammary carcinogenesis in two animal models. In the Fisher rat, an animal model of mammary cancer that is estrogen receptor dependent, tumors were initiated by the injection of N-methylurea (NMU). The rat survival was significantly increased by the daily injection of Talpha1. In the SV40T antigen mouse, a transgenic female mouse that spontaneously gets mammary cancer in an estrogen receptor-independent manner, survival was increased and tumor burden was significantly decreased by daily injection of Talpha1. These results indicate that Talpha1 is a chemopreventive agent in animal models for lung and breast carcinogenesis.
JF  - Annals of the New York Academy of Sciences
AU  - Moody, Terry W
AD  - Department of Health and Human Services, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. moodyt@mail.nih.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 297
EP  - 304
VL  - 1112
SN  - 0077-8923, 0077-8923
KW  - Anticarcinogenic Agents
KW  - 0
KW  - Thymosin
KW  - 61512-21-8
KW  - thymalfasin
KW  - W0B22ISQ1C
KW  - Index Medicus
KW  - Rats
KW  - Mice, Inbred A
KW  - Animals
KW  - Rats, Inbred F344
KW  - Adenoma -- prevention & control
KW  - Mice
KW  - Female
KW  - Lung Neoplasms -- prevention & control
KW  - Anticarcinogenic Agents -- therapeutic use
KW  - Thymosin -- therapeutic use
KW  - Mammary Neoplasms, Animal -- prevention & control
KW  - Thymosin -- analogs & derivatives
KW  - Mammary Neoplasms, Animal -- chemically induced
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Thymosin+alpha1+as+a+chemopreventive+agent+in+lung+and+breast+cancer.&rft.au=Moody%2C+Terry+W&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2007-09-01&rft.volume=1112&rft.issue=&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-27
N1  - Date created - 2007-10-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Gene expression profiling of MPP+-treated MN9D cells: a mechanism of toxicity study.
AN  - 68369030; 17475336
AB  - Parkinson's disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons with unknown etiology. MPP+ (1-methyl-4-phenylpyridinium) is the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which induces Parkinson's-like syndromes in humans and animals. MPTP/MPP+ treatment produces selective dopaminergic neuronal degeneration, therefore, these agents are commonly used to study the pathogenesis of PD. However, the mechanisms of their toxicity have not been elucidated. In order to gain insights into MPP+-induced neurotoxicity, a gene expression microarray study was performed using a midbrain-derived dopaminergic neuronal cell line, MN9D. Utilizing a two-color reference design, Agilent mouse oligonucleotide microarrays were used to examine relative gene expression changes in MN9D cells treated with 40microM MPP+ compared with controls. Bioinformatics tools were used for data evaluation. Briefly, raw data were imported into the NCTR ArrayTrack database, normalized using a Lowess method and data quality was assessed. The Student's t-test was used to determine significant changes in gene expression (set as p1.5). Gene Ontology for Function Analysis (GOFFA) and Ingenuity Pathway Analysis were employed to analyze the functions and roles of significant genes in biological processes. Of the 51 significant genes identified, 44 were present in the GOFFA or Ingenuity database. These data indicate that multiple pathways are involved in the underlying mechanisms of MPP+-induced neurotoxicity, including apoptosis, oxidative stress, iron binding, cellular metabolism, and signal transduction. These data also indicate that MPP+-induced toxicity shares common molecular mechanisms with the pathogenesis of PD and further pathway analyses will be conducted to explore these mechanisms.
JF  - Neurotoxicology
AU  - Wang, Jianyong
AU  - Xu, Zengjun
AU  - Fang, Hong
AU  - Duhart, Helen M
AU  - Patterson, Tucker A
AU  - Ali, Syed F
AD  - Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA.
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 979
EP  - 987
VL  - 28
IS  - 5
SN  - 0161-813X, 0161-813X
KW  - Dopamine Agents
KW  - 0
KW  - Neurotransmitter Transport Proteins
KW  - 1-Methyl-4-phenylpyridinium
KW  - R865A5OY8J
KW  - Index Medicus
KW  - Animals
KW  - Neurotransmitter Transport Proteins -- drug effects
KW  - Oligonucleotide Array Sequence Analysis
KW  - Cell Division -- physiology
KW  - Oxidative Stress -- genetics
KW  - Mice
KW  - Electric Stimulation
KW  - Neurotransmitter Transport Proteins -- genetics
KW  - Gene Expression Profiling
KW  - Apoptosis -- genetics
KW  - Cells, Cultured
KW  - Signal Transduction -- drug effects
KW  - Apoptosis -- drug effects
KW  - Signal Transduction -- genetics
KW  - Oxidative Stress -- drug effects
KW  - Data Interpretation, Statistical
KW  - Cluster Analysis
KW  - Cell Division -- genetics
KW  - Dopamine Agents -- toxicity
KW  - 1-Methyl-4-phenylpyridinium -- toxicity
KW  - Neurons -- drug effects
KW  - Neurons -- pathology
KW  - MPTP Poisoning -- genetics
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Gene+expression+profiling+of+MPP%2B-treated+MN9D+cells%3A+a+mechanism+of+toxicity+study.&rft.au=Wang%2C+Jianyong%3BXu%2C+Zengjun%3BFang%2C+Hong%3BDuhart%2C+Helen+M%3BPatterson%2C+Tucker+A%3BAli%2C+Syed+F&rft.aulast=Wang&rft.aufirst=Jianyong&rft.date=2007-09-01&rft.volume=28&rft.issue=5&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-26
N1  - Date created - 2007-10-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Effects of chronic low-dose acrylamide exposure on progressive ratio performance in adolescent rats.
AN  - 68360204; 17720246
AB  - Acrylamide (ACR) is a neurotoxicant known to produce peripheral neuropathy in rats and humans, but little is known of its potential for producing cognitive or motivational alterations. Chronic exposure to low doses of ACR as a food contaminant is known to occur widely in humans. This research evaluated the effects of daily ACR exposure on food-motivated behavior, with exposures beginning prenatally on gestation day 6 and continuing through approximately postnatal day (PND) 85. Plug-positive Fischer 344 dams (9-10 per dose) were gavaged daily with 0, 0.1, 0.3, 1.0 or 5.0mg/kg/day ACR. On PNDs 1-22, pups were gavaged with the same dose their dam had received. On PND 22, pups were weaned and pair-housed with a same-sex littermate and ACR exposure continued at 0, 1, 3, 10 and 50ppm via drinking water. One male and one female pup per litter were tested in an operant chamber under a progressive ratio (PR) schedule of food reinforcement from approximately 6 to 12 weeks of age. Results over 6 weeks of testing indicated a significant treatment effect of ACR on number of reinforcers earned, with Tukey HSD post hoc tests revealing significantly fewer reinforcers earned in the 5.0mg/kg/day dose group than in controls. A significant effect of ACR on response rate was also observed, with the Tukey HSD post hoc tests revealing a significantly lower response rate in the 5.0mg/kg/day group than in controls. No effects of ACR were observed on post-reinforcement pause. These data suggest that daily ACR exposure at 5.0mg/kg/day can produce measurable decrements on aspects of food-motivated behavior.
JF  - Neurotoxicology
AU  - Garey, Joan
AU  - Paule, Merle G
AD  - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, HFT-132, Jefferson, AR 72079, USA. joan.garey@fda.hhs.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 998
EP  - 1002
VL  - 28
IS  - 5
SN  - 0161-813X, 0161-813X
KW  - Acrylamide
KW  - 20R035KLCI
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Rats, Inbred F344
KW  - Reinforcement Schedule
KW  - Motivation
KW  - Body Weight -- drug effects
KW  - Male
KW  - Female
KW  - Pregnancy
KW  - Conditioning, Operant -- drug effects
KW  - Psychomotor Performance -- drug effects
KW  - Acrylamide -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-26
N1  - Date created - 2007-10-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - What is being done to address the new drug epidemic?
AN  - 68333604; 17908827
AB  - As osteopathic physicians care for patients with complaints of pain, they commonly prescribe controlled substances. The use of these agents presents special challenges for providers, patients, and communities. The US Drug Enforcement Administration (DEA) has provided testimony to the US Congress in regard to the growing problem of diversion and misuse of such medications. Joseph T. Rannazzisi, the deputy assistant administrator in the Office of Diversion Control, appeared before the House Government Reform Committee's Subcommittee on Criminal Justice, Drug Policy, and Human Resources on July 26, 2006.
JF  - The Journal of the American Osteopathic Association
AU  - Dekker, Anthony H
AD  - Phoenix Indian Medical Center, Indian Health Service, USPHS, 4212 N 16th Street, Phoenix, AZ 85016-5319, USA. Anthony.Dekker@ihs.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - ES21
EP  - ES26
VL  - 107
IS  - 9 Suppl 5
KW  - Analgesics, Opioid
KW  - 0
KW  - Index Medicus
KW  - Humans
KW  - United States -- epidemiology
KW  - Opioid-Related Disorders -- epidemiology
KW  - Pain, Intractable -- drug therapy
KW  - Drug and Narcotic Control -- trends
KW  - Drug Prescriptions -- standards
KW  - Drug and Narcotic Control -- legislation & jurisprudence
KW  - Analgesics, Opioid -- therapeutic use
KW  - Analgesics, Opioid -- adverse effects
KW  - Opioid-Related Disorders -- prevention & control
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68333604?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+American+Osteopathic+Association&rft.atitle=What+is+being+done+to+address+the+new+drug+epidemic%3F&rft.au=Dekker%2C+Anthony+H&rft.aulast=Dekker&rft.aufirst=Anthony&rft.date=2007-09-01&rft.volume=107&rft.issue=9+Suppl+5&rft.spage=ES21&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+American+Osteopathic+Association&rft.issn=1945-1997&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-01
N1  - Date created - 2007-10-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study.
AN  - 68327410; 17617661
AB  - High consumption of cruciferous vegetables has been associated with reduced kidney cancer risk in many studies. Isothiocyanates, thought to be responsible for the chemopreventive properties of this food group, are conjugated to glutathione by glutathione S-transferases (GSTs) before urinary excretion. Modification of this relationship by host genetic factors is unknown. We investigated cruciferous vegetable intake in 1097 cases and 1555 controls enrolled in a multicentric case-control study from the Czech Republic, Poland, Romania and Russia. To assess possible gene-diet interactions, genotyped cases (N = 925) and controls (N = 1247) for selected functional or non-synonymous polymorphisms including the GSTM1 deletion, GSTM3 3 bp deletion (IVS6 + 22-AGG) and V224I G>A substitution, GSTT1 deletion and the GSTP1 I105V A>G substitution. The odds ratio (OR) for low (less than once per month) versus high (at least once per week) intake of cruciferous vegetables was 1.29 [95% confidence interval (CI): 1.02-1.62; P-trend = 0.03]. When low intake of cruciferous vegetables (less than once per month) was stratified by GST genotype, higher kidney cancer risks were observed among individuals with the GSTT1 null (OR = 1.86; 95% CI: 1.07-3.23; P-interaction = 0.05) or with both GSTM1/T1 null genotypes (OR = 2.49; 95% CI: 1.08-5.77; P-interaction = 0.05). These data provide additional evidence for the role of cruciferous vegetables in cancer prevention among individuals with common, functional genetic polymorphisms.
JF  - Carcinogenesis
AU  - Moore, L E
AU  - Brennan, P
AU  - Karami, S
AU  - Hung, R J
AU  - Hsu, C
AU  - Boffetta, P
AU  - Toro, J
AU  - Zaridze, D
AU  - Janout, V
AU  - Bencko, V
AU  - Navratilova, M
AU  - Szeszenia-Dabrowska, N
AU  - Mates, D
AU  - Mukeria, A
AU  - Holcatova, I
AU  - Welch, R
AU  - Chanock, S
AU  - Rothman, N
AU  - Chow, W-H
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. moorele@mail.nih.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 1960
EP  - 1964
VL  - 28
IS  - 9
SN  - 0143-3334, 0143-3334
KW  - DNA
KW  - 9007-49-2
KW  - Glutathione Transferase
KW  - EC 2.5.1.18
KW  - Index Medicus
KW  - Polymorphism, Single Nucleotide
KW  - Humans
KW  - Aged
KW  - Europe -- epidemiology
KW  - Feeding Behavior
KW  - Genotype
KW  - DNA -- isolation & purification
KW  - Europe, Eastern -- epidemiology
KW  - Risk Factors
KW  - DNA -- blood
KW  - Adult
KW  - DNA -- genetics
KW  - Interviews as Topic
KW  - Middle Aged
KW  - Male
KW  - Female
KW  - Sequence Deletion
KW  - Kidney Neoplasms -- genetics
KW  - Vegetables
KW  - Brassicaceae
KW  - Polymorphism, Genetic
KW  - Kidney Neoplasms -- epidemiology
KW  - Glutathione Transferase -- genetics
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Glutathione+S-transferase+polymorphisms%2C+cruciferous+vegetable+intake+and+cancer+risk+in+the+Central+and+Eastern+European+Kidney+Cancer+Study.&rft.au=Moore%2C+L+E%3BBrennan%2C+P%3BKarami%2C+S%3BHung%2C+R+J%3BHsu%2C+C%3BBoffetta%2C+P%3BToro%2C+J%3BZaridze%2C+D%3BJanout%2C+V%3BBencko%2C+V%3BNavratilova%2C+M%3BSzeszenia-Dabrowska%2C+N%3BMates%2C+D%3BMukeria%2C+A%3BHolcatova%2C+I%3BWelch%2C+R%3BChanock%2C+S%3BRothman%2C+N%3BChow%2C+W-H&rft.aulast=Moore&rft.aufirst=L&rft.date=2007-09-01&rft.volume=28&rft.issue=9&rft.spage=1960&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-03-14
N1  - Date created - 2007-09-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Toxicity assessment of unintentional exposure to multiple chemicals.
AN  - 68247386; 17599373
AB  - Typically exposure to environmental chemicals is unintentional, and often the exposure is to chemical mixtures, either simultaneously or sequentially. When exposure occurs, in public health practice, it is prudent to ascertain if thresholds for harmful health effects are exceeded, whether by individual chemicals or by chemicals in combination. Three alternative approaches are available for assessing the toxicity of chemical mixtures. Each approach, however, has shortcomings. As the procedures of each approach are described in this paper, at various steps research needs are identified. Recently, reliance has increased on computational toxicology methods for predicting toxicological effects when data are limited. Advances in molecular biology, identification of biomarkers, and availability of accurate and sensitive methods allow us to more precisely define the relationships between multiple chemical exposures and health effects, both qualitatively and quantitatively. Key research needs are best fulfilled through collaborative research. It is through such collaborations that resources are most effectively leveraged to further develop and apply toxicity assessment methods that advance public health practices in vulnerable communities.
JF  - Toxicology and applied pharmacology
AU  - Mumtaz, M M
AU  - Ruiz, P
AU  - De Rosa, C T
AD  - Division of Toxicology and Environmental Medicine Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA. mgm4@cdc.gov
Y1  - 2007/09/01/
PY  - 2007
DA  - 2007 Sep 01
SP  - 104
EP  - 113
VL  - 223
IS  - 2
SN  - 0041-008X, 0041-008X
KW  - Hazardous Substances
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Systems Integration
KW  - Humans
KW  - Computational Biology
KW  - Risk Assessment -- methods
KW  - Models, Theoretical
KW  - Toxicology -- trends
KW  - Environmental Exposure -- analysis
KW  - Hazardous Substances -- poisoning
KW  - Toxicology -- methods
KW  - Environmental Exposure -- prevention & control
KW  - Hazardous Substances -- analysis
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Toxicity+assessment+of+unintentional+exposure+to+multiple+chemicals.&rft.au=Mumtaz%2C+M+M%3BRuiz%2C+P%3BDe+Rosa%2C+C+T&rft.aulast=Mumtaz&rft.aufirst=M&rft.date=2007-09-01&rft.volume=223&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-30
N1  - Date created - 2007-09-07
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Maternal serum polychlorinated biphenyl concentrations across critical windows of human development.
AN  - 68241658; 17805422
AB  - Few data are available on polychlorinated biphenyl (PCB) concentrations over critical windows of human reproduction and development inclusive of the periconception window.
          Our goal was to measure changes in PCB concentrations from preconception to pregnancy, through pregnancy, or after a year without becoming pregnant. Seventy-nine women planning pregnancies were prospectively enrolled and followed for up to 12 menstrual cycles of attempting pregnancy. Blood specimens were obtained from participating women preconceptionally (n = 79), after a positive pregnancy test leading to a live birth (n = 54) or pregnancy loss (n = 10), at approximately 6 weeks postpartum (n = 53), and after 12 unsuccessful cycles (n = 9) for toxicologic analysis of 76 PCB congeners. We estimated overall and daily rate of change in PCB concentration (nanograms per gram serum) adjusting for relevant covariates, serum lipids, and baseline PCB concentration.
          Significant (p < 0.0001) decreases in the mean overall and daily rate of change in PCB concentrations were observed between the preconception and first pregnancy samples for total (-1.012 and -0.034, respectively), estrogenic (-0.444 and -0.016, respectively), and antiestrogenic (-0.106 and -0.004, respectively) PCBs among women with live births. Similar significant decreases in total (-1.452 and -0.085), estrogenic (-0.647 and -0.040), and antiestrogenic (-0.093 and -0.004) PCB concentrations were seen for women with pregnancy losses. No significant changes were observed for PCB congener 153.
          These data suggest that PCB concentrations may change during the periconception interval, questioning the stability of persistent compounds during this critical window.
JF  - Environmental health perspectives
AU  - Bloom, Michael S
AU  - Buck Louis, Germaine M
AU  - Schisterman, Enrique F
AU  - Liu, Aiyi
AU  - Kostyniak, Paul J
AD  - Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 1320
EP  - 1324
VL  - 115
IS  - 9
SN  - 0091-6765, 0091-6765
KW  - Environmental Pollutants
KW  - 0
KW  - Polychlorinated Biphenyls
KW  - DFC2HB4I0K
KW  - Index Medicus
KW  - critical windows
KW  - polychlorinated biphenyls (PCBs)
KW  - persistent organic pollutants
KW  - infertility
KW  - periconception
KW  - pregnancy loss
KW  - Infant
KW  - Embryonic Development
KW  - Postpartum Period -- blood
KW  - Humans
KW  - Adult
KW  - Child Development
KW  - Fetal Development
KW  - Female
KW  - Pregnancy
KW  - Polychlorinated Biphenyls -- blood
KW  - Environmental Pollutants -- blood
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-15
N1  - Date created - 2007-09-06
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Epidemiology. 2000 Jul;11(4):388-93 [10874544]
Am J Epidemiol. 2006 Feb 15;163(4):374-83 [16394206]
Environ Sci Technol. 2001 Feb 1;35(3):435-40 [11351711]
Environ Res. 2001 Jun;86(2):128-39 [11437459]
J Toxicol Environ Health A. 2001 Nov 23;64(6):485-98 [11732699]
Am J Epidemiol. 2003 Feb 15;157(4):355-63 [12578806]
Environ Health Perspect. 2003 Mar;111(3):349-55 [12611665]
Environ Health Perspect. 2003 Jul;111(9):1253-8 [12842782]
Environ Health Perspect. 2004 Jan;112(1):69-78 [14698934]
Environ Health Perspect. 2004 Jan;112(1):79-86 [14698935]
Environ Health Perspect. 2004 Feb;112(2):266-71 [14754582]
Epidemiology. 2004 Sep;15(5):615-25 [15308962]
Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495-500 [2505694]
Sci Total Environ. 1995 Jan 15;160-161:529-37 [7892583]
Toxicol Ind Health. 1996 May-Aug;12(3-4):327-34 [8843550]
Arch Environ Contam Toxicol. 1997 Apr;32(3):329-36 [9096084]
Teratology. 1997 May;55(5):338-47 [9261928]
J Anal Toxicol. 1997 Nov-Dec;21(7):558-66 [9399126]
Arch Environ Health. 1999 Mar-Apr;54(2):110-4 [10094288]
Environ Res. 1999 Feb;80(2 Pt 2):S166-S174 [10092430]
Environ Res. 2005 Feb;97(2):134-41 [15533329]
Environ Res. 2005 Feb;97(2):178-94 [15533334]
Environ Health Perspect. 2005 Jul;113(7):853-7 [16002372]
Environ Health. 2005;4:10 [15927085]
Obstet Gynecol. 2001 May;97(5 Pt 1):669-72 [11339913]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Workgroup report: National Toxicology Program workshop on Hormonally Induced Reproductive Tumors - Relevance of Rodent Bioassays.
AN  - 68239502; 17805427
AB  - The National Toxicology Program (NTP) is currently reviewing its research portfolio as part of its efforts to implement the NTP Roadmap to achieve the NTP Vision for the 21st century. This review includes a recent workshop, "Hormonally Induced Reproductive Tumors-Relevance of Rodent Bioassays," held 22-24 May 2006, that was organized to determine the adequacy and relevance to human disease outcome of rodent models currently used in the 2-year bioassay for four types of hormonally induced reproductive tumors (ovary, mammary gland, prostate, and testis). In brief, none of the workshop's breakout groups felt the currently used models are sufficient. For some types of tumors such as prostate, no adequate animal models exist, and for others such as ovary, the predominant tumors in humans are of different cellular origins than those induced by chemicals in rodents. This inadequacy of current models also applies to the testis, although our more complete understanding of the responses of Leydig cells to hormonal changes in rats may prove predictive for effects in humans other than cancer. All breakout groups recommended that the NTP consider modifying its testing protocols (i.e., age at exposure, additional end points, etc.) and/or using alternative models (i.e., genetically engineered models, in vitro systems, etc.) to improve sensitivity. In this article we briefly review the workshop's outcome and outline some next steps forward in pursuing the workshop's recommendations. Breakout group reports and additional information on the workshop, including participants, presentations, public comments and background materials, are posted on the NTP website.
JF  - Environmental health perspectives
AU  - Thayer, Kristina A
AU  - Foster, Paul M
AD  - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 1351
EP  - 1356
VL  - 115
IS  - 9
SN  - 0091-6765, 0091-6765
KW  - Carcinogens
KW  - 0
KW  - Hormones
KW  - Index Medicus
KW  - breast
KW  - prostate
KW  - species differences
KW  - ovary
KW  - reproductive tumors
KW  - National Toxicology Program
KW  - animal models
KW  - testis
KW  - endocrine
KW  - mammary gland
KW  - hormone
KW  - Rats
KW  - Animals
KW  - Rats, Inbred F344
KW  - Government Programs
KW  - Carcinogenicity Tests
KW  - Mice
KW  - Federal Government
KW  - Models, Animal
KW  - Urogenital Neoplasms -- chemically induced
KW  - Carcinogens -- toxicity
KW  - Breast Neoplasms -- chemically induced
KW  - Hormones -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-15
N1  - Date created - 2007-09-06
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
J Mammary Gland Biol Neoplasia. 1998 Jan;3(1):49-61 [10819504]
Toxicol Pathol. 2006;34(6):802-5 [17162538]
J Pathol. 2003 Mar;199(3):378-86 [12579540]
Toxicol Sci. 2004 Oct;81(2):401-7 [15240895]
Fundam Appl Toxicol. 1993 Aug;21(2):174-86 [8405780]
Fundam Appl Toxicol. 1993 Nov;21(4):451-60 [8253298]
Neoplasma. 1998;45(6):373-6 [10210111]
Crit Rev Toxicol. 1999 Mar;29(2):169-261 [10213111]
Toxicol Pathol. 2005;33(3):386-97 [15805078]
J Appl Toxicol. 2005 Nov-Dec;25(6):514-21 [16158390]
Prostate. 2006 Jan 1;66(1):57-69 [16114064]
J Appl Toxicol. 2006 Jan-Feb;26(1):72-80 [16193534]
Environ Health Perspect. 2006 Jun;114(6):A348-9 [16759971]
Natl Toxicol Program Tech Rep Ser. 2006 Apr;(521):4-232 [16835633]
Natl Toxicol Program Tech Rep Ser. 2006 May;(529):4-168 [16835634]
Toxicol Pathol. 2001 Nov-Dec;29(6):639-52 [11794380]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Stimulating the development of mechanism-based, individualized pain therapies.
AN  - 68225050; 17762885
AB  - Biomedical science has greatly improved our understanding of pain in recent decades, but few novel molecular entities that address fundamentally new pain mechanisms have entered the clinic, despite dramatically increased pharmaceutical investment. Indeed, virtually all new analgesics approved over the past 25 years are derivatives or reformulations of opioids or aspirin-like drugs, existing drugs given for a new indication or older drugs given by a different route of administration. Here, we discuss factors contributing to this lack of innovation in therapies for pain and advocate public-private partnerships (PPPs) to translate new knowledge into more efficacious and safer treatments.
JF  - Nature reviews. Drug discovery
AU  - Woodcock, Janet
AU  - Witter, James
AU  - Dionne, Raymond A
AD  - Food and Drug Administration, Department of Health and Human Services, Rockville, Maryland, USA.
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 703
EP  - 710
VL  - 6
IS  - 9
SN  - 1474-1776, 1474-1776
KW  - Analgesics
KW  - 0
KW  - Index Medicus
KW  - Drug Therapy, Combination
KW  - Animals
KW  - Drug Interactions
KW  - Humans
KW  - Clinical Trials as Topic
KW  - Disease Models, Animal
KW  - Pain -- drug therapy
KW  - Analgesics -- pharmacology
KW  - Drug Design
KW  - Analgesics -- therapeutic use
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-12
N1  - Date created - 2007-08-31
N1  - Date revised - 2017-02-10
N1  - Last updated - 2017-02-10
DO  - http://dx.doi.org/10.1038/nrd2335
ER  - 



TY  - JOUR
T1  - Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR.
AN  - 68223253; 17526437
AB  - This study describes the development of a mitochondria-specific microarray, MitoChip, to measure transcripts of mitochondria-associated genes in various diseases and drug-induced toxicities in the mouse. The array consists of 542 oligonucleotides that represent genes from the mitochondrial and nuclear genomes associated with mitochondrial structure and functions. The expression of mitochondrial genes was measured in the liver of both p53 haplodeficient (+/-) and wild-type (+/+) C3B6F(1) female mice exposed to antiretroviral agents, Zidovudine (AZT) and Lamivudine (3TC). Among genes whose expression was significantly altered, a set was selected for real-time PCR analysis to verify their differential gene expression. The real-time PCR data confirmed the observations by microarray analysis suggesting that the MitoChip may be an important tool for examining mitochondrial involvement in diseases and drug-induced toxicities.
JF  - Mitochondrion
AU  - Desai, Varsha G
AU  - Lee, Taewon
AU  - Delongchamp, Robert R
AU  - Moland, Carrie L
AU  - Branham, William S
AU  - Fuscoe, James C
AU  - Leakey, Julian E A
AD  - Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. varsha.desai@fda.hhs.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 322
EP  - 329
VL  - 7
IS  - 5
SN  - 1567-7249, 1567-7249
KW  - Lamivudine
KW  - 2T8Q726O95
KW  - Zidovudine
KW  - 4B9XT59T7S
KW  - Index Medicus
KW  - Polymerase Chain Reaction
KW  - Animals
KW  - Zidovudine -- pharmacology
KW  - Lamivudine -- pharmacology
KW  - Mice
KW  - Male
KW  - Gene Expression Profiling -- methods
KW  - Female
KW  - Mitochondria -- physiology
KW  - Mitochondria -- drug effects
KW  - Oligonucleotide Array Sequence Analysis -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-05
N1  - Date created - 2007-08-31
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Analysis of food for toxic elements.
AN  - 68196079; 17609933
AB  - The levels of the toxic elements Al, As, Cd, Hg, Pb and Sn are routinely monitored in food to protect the consumer. Increasingly, the chemical forms of As and Hg are also monitored. Analyses are performed to enforce regulatory standards and to accumulate background levels for assessing long-term exposure. The analytical procedures used for these activities evolve as requirements to determine lower levels arise and as both the types and sheer number of different foods that need to be analyzed increase. This review highlights recent work addressing improvements in the analysis of toxic elements in food. The topics covered include contamination control, analytical sample treatment and the common analytical techniques used for food analysis.
JF  - Analytical and bioanalytical chemistry
AU  - Capar, Stephen G
AU  - Mindak, William R
AU  - Cheng, John
AD  - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Harvey W. Wiley Federal Building, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA. stephen.capar@fda.hhs.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 159
EP  - 169
VL  - 389
IS  - 1
SN  - 1618-2642, 1618-2642
KW  - Hazardous Substances
KW  - 0
KW  - Metals
KW  - Index Medicus
KW  - Hazardous Substances -- administration & dosage
KW  - Animals
KW  - Metals -- administration & dosage
KW  - Humans
KW  - Metals -- analysis
KW  - Hazardous Substances -- analysis
KW  - Food Analysis
KW  - Food Contamination -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-17
N1  - Date created - 2007-08-23
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Recent studies on selected botanical dietary supplement ingredients.
AN  - 68195924; 17390125
AB  - The market for botanical dietary supplements in the US has grown rapidly during the last 15 years. Use of newly introduced botanical ingredients has often outpaced an adequate scientific understanding of the ingredients themselves. This may lead to problems, including misidentification, mislabeling, adulteration, and toxicity related to the intended ingredient or one substituted for it. This article reviews recent work with several botanical ingredients (Ephedra, Citrus species, Hoodia gordonii, Teucrium, isoflavones) that illustrates the complexity of the current situation and approaches that contribute to ensuring the quality of botanical ingredients. Recent work with contamination of botanical products by mycotoxins is also reviewed. The need for tools for botanical authentication and methods for reproducible extraction of bioactive constituents is critical. Such tools, and improved analytical techniques for identifying potentially bioactive constituents in fresh plant material and in concentrated extracts and for detection of hazardous contaminants, are expected to improve the overall quality and safety of botanical dietary supplement ingredients.
JF  - Analytical and bioanalytical chemistry
AU  - Rader, Jeanne I
AU  - Delmonte, Pierluigi
AU  - Trucksess, Mary W
AD  - Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Jeanne.Rader@fda.hhs.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 27
EP  - 35
VL  - 389
IS  - 1
SN  - 1618-2642, 1618-2642
KW  - Isoflavones
KW  - 0
KW  - Mycotoxins
KW  - Plant Extracts
KW  - Index Medicus
KW  - Isoflavones -- analysis
KW  - Isoflavones -- chemistry
KW  - Mycotoxins -- chemistry
KW  - Mycotoxins -- analysis
KW  - Dietary Supplements -- standards
KW  - Plant Extracts -- chemistry
KW  - Dietary Supplements -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-17
N1  - Date created - 2007-08-23
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Follow-up study of chrysotile textile workers: cohort mortality and exposure-response.
AN  - 68183340; 17449563
AB  - This report provides an update of the mortality experience of a cohort of South Carolina asbestos textile workers.
          A cohort of 3072 workers exposed to chrysotile in a South Carolina asbestos textile plant (1916-77) was followed up for mortality through 2001. Standardised mortality ratios (SMRs) were computed using US and South Carolina mortality rates. A job exposure matrix provided calendar time dependent estimates of chrysotile exposure concentrations. Poisson regression models were fitted for lung cancer and asbestosis. Covariates considered included sex, race, age, calendar time, birth cohort and time since first exposure. Cumulative exposure lags of 5 and 10 years were considered by disregarding exposure in the most recent 5 and 10 years, respectively.
          A majority of the cohort was deceased (64%) and 702 of the 1961 deaths occurred since the previous update. Mortality was elevated based on US referent rates for a priori causes of interest including all causes combined (SMR 1.33, 95% CI 1.28 to 1.39); all cancers (SMR 1.27, 95% CI 1.16 to 1.39); oesophageal cancer (SMR 1.87, 95% CI 1.09 to 2.99); lung cancer (SMR 1.95, 95% CI 1.68 to 2.24); ischaemic heart disease (SMR 1.20, 95% CI 1.10 to 1.32); and pneumoconiosis and other respiratory diseases (SMR 4.81, 95% CI 3.84 to 5.94). Mortality remained elevated for these causes when South Carolina referent rates were used. Three cases of mesothelioma were observed among cohort members. Exposure-response modelling for lung cancer, using a linear relative risk model, produced a slope coefficient of 0.0198 (fibre-years/ml) (standard error 0.00496), when cumulative exposure was lagged 10 years. Poisson regression modelling confirmed significant positive relations between estimated chrysotile exposure and lung cancer and asbestosis mortality observed in previous updates of this cohort. This study confirms the findings from previous investigations of excess mortality from lung cancer and asbestosis and a strong exposure-response relation between estimated exposure to chrysotile and mortality from lung cancer and asbestosis.
JF  - Occupational and environmental medicine
AU  - Hein, Misty J
AU  - Stayner, Leslie T
AU  - Lehman, Everett
AU  - Dement, John M
AD  - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. MHein@cdc.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 616
EP  - 625
VL  - 64
IS  - 9
KW  - Asbestos, Serpentine
KW  - 0
KW  - Index Medicus
KW  - Epidemiologic Methods
KW  - Humans
KW  - Adult
KW  - Aged
KW  - Middle Aged
KW  - Male
KW  - Female
KW  - Lung Neoplasms -- etiology
KW  - Asbestos, Serpentine -- toxicity
KW  - Occupational Diseases -- etiology
KW  - Occupational Exposure -- adverse effects
KW  - Textile Industry -- statistics & numerical data
KW  - Lung Neoplasms -- mortality
KW  - Occupational Diseases -- mortality
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-17
N1  - Date created - 2007-08-20
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Ann Occup Hyg. 2000 Dec;44(8):565-601 [11108782]
J Occup Environ Med. 2006 Jul;48(7):662-7 [16832222]
Ann Epidemiol. 2002 Aug;12(6):363-9 [12160594]
Ann Epidemiol. 2004 Oct;14(9):633-9 [15380793]
Int J Epidemiol. 2004 Oct;33(5):1040-5 [15155700]
Occup Environ Med. 2004 Nov;61(11):930-5 [15477287]
Am J Epidemiol. 1982 Jul;116(1):177-88 [7102651]
J Occup Med. 1983 Feb;25(2):115-24 [6687607]
Am J Ind Med. 1983;4(3):399-419 [6846338]
Am J Ind Med. 1983;4(3):421-33 [6846339]
J Occup Med. 1990 Nov;32(11):1091-8 [2258764]
J Occup Med. 1994 Aug;36(8):882-8 [7807269]
Am J Ind Med. 1994 Oct;26(4):431-47 [7810543]
Risk Anal. 1995 Apr;15(2):181-95 [7597255]
Stat Med. 1995 Oct 15;14(19):2119-29 [8552891]
Am J Public Health. 1996 Feb;86(2):179-86 [8633733]
Am J Public Health. 1996 Feb;86(2):231-6 [8633741]
Ann Occup Hyg. 1997 Dec;41(6):699-705 [9375528]
Occup Environ Med. 1997 Sep;54(9):646-52 [9423577]
Am J Epidemiol. 1999 Feb 15;149(4):347-52 [10025477]
Ind Health. 1999 Jul;37(3):271-80 [10441898]
Radiat Res. 1999 Oct;152(4):339-51 [10477911]
Am J Epidemiol. 2001 Sep 15;154(6):538-43 [11549559]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Role of the catalytic metal during polymerization by DNA polymerase lambda.
AN  - 68177083; 17475573
AB  - The incorporation of dNMPs into DNA by polymerases involves a phosphoryl transfer reaction hypothesized to require two divalent metal ions. Here we investigate this hypothesis using as a model human DNA polymerase lambda (Pol lambda), an enzyme suggested to be activated in vivo by manganese. We report the crystal structures of four complexes of human Pol lambda. In a 1.9 A structure of Pol lambda containing a 3'-OH and the non-hydrolyzable analog dUpnpp, a non-catalytic Na+ ion occupies the site for metal A and the ribose of the primer-terminal nucleotide is found in a conformation that positions the acceptor 3'-OH out of line with the alpha-phosphate and the bridging oxygen of the pyrophosphate leaving group. Soaking this crystal in MnCl2 yielded a 2.0 A structure with Mn2+ occupying the site for metal A. In the presence of Mn2+, the conformation of the ribose is C3'-endo and the 3'-oxygen is in line with the leaving oxygen, at a distance from the phosphorus atom of the alpha-phosphate (3.69 A) consistent with and supporting a catalytic mechanism involving two divalent metal ions. Finally, soaking with MnCl2 converted a pre-catalytic Pol lambda/Na+ complex with unreacted dCTP in the active site into a product complex via catalysis in the crystal. These data provide pre- and post-transition state information and outline in a single crystal the pathway for the phosphoryl transfer reaction carried out by DNA polymerases.
JF  - DNA repair
AU  - Garcia-Diaz, Miguel
AU  - Bebenek, Katarzyna
AU  - Krahn, Joseph M
AU  - Pedersen, Lars C
AU  - Kunkel, Thomas A
AD  - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Y1  - 2007/09/01/
PY  - 2007
DA  - 2007 Sep 01
SP  - 1333
EP  - 1340
VL  - 6
IS  - 9
SN  - 1568-7864, 1568-7864
KW  - Phosphates
KW  - 0
KW  - Manganese
KW  - 42Z2K6ZL8P
KW  - DNA
KW  - 9007-49-2
KW  - DNA Polymerase beta
KW  - EC 2.7.7.-
KW  - DNA polymerase beta2
KW  - Index Medicus
KW  - Phosphates -- metabolism
KW  - Crystallization
KW  - Models, Molecular
KW  - Humans
KW  - Crystallography, X-Ray
KW  - Protein Binding
KW  - Protein Conformation
KW  - Catalysis
KW  - Binding Sites
KW  - Manganese -- pharmacology
KW  - DNA Polymerase beta -- genetics
KW  - DNA -- metabolism
KW  - DNA Polymerase beta -- chemistry
KW  - DNA -- chemistry
KW  - DNA Polymerase beta -- metabolism
KW  - Mutagenesis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-25
N1  - Date created - 2007-08-20
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
J Biol Chem. 2001 Sep 14;276(37):34659-63 [11457865]
Mol Cell. 2005 Aug 5;19(3):357-66 [16061182]
Proteins. 2003 Feb 15;50(3):437-50 [12557186]
Biochemistry. 2003 Jun 24;42(24):7467-76 [12809503]
Biochemistry. 2003 Aug 19;42(32):9564-74 [12911298]
J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698]
J Biol Chem. 2004 Jan 2;279(1):805-11 [14561766]
Mol Cell. 2004 Feb 27;13(4):561-72 [14992725]
Biochemistry. 2004 Jun 1;43(21):6751-62 [15157109]
J Biol Chem. 1972 Nov 10;247(21):6784-94 [4343158]
J Biol Chem. 1979 Aug 10;254(15):6889-93 [378995]
J Biol Chem. 1990 Aug 25;265(24):14327-34 [2201684]
EMBO J. 1991 Jan;10(1):25-33 [1989886]
Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413]
Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107]
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765]
Mol Cell. 2004 Dec 3;16(5):701-13 [15574326]
Nat Struct Mol Biol. 2005 Jan;12(1):97-8 [15608652]
J Biol Chem. 2005 May 6;280(18):18469-75 [15749700]
EMBO J. 2005 Sep 7;24(17):2957-67 [16107880]
J Biol Chem. 2005 Sep 9;280(36):31641-7 [16002405]
DNA Repair (Amst). 2005 Dec 8;4(12):1358-67 [16213194]
Cell. 2006 Jan 27;124(2):331-42 [16439207]
Mol Cell. 2006 Apr 7;22(1):5-13 [16600865]
Structure. 2006 Apr;14(4):757-66 [16615916]
Nucleic Acids Res. 2006;34(11):3259-66 [16807316]
Immunity. 2006 Jul;25(1):31-41 [16860755]
Radiat Res. 2006 Nov;166(5):693-714 [17067213]
Annu Rev Biochem. 2002;71:133-63 [12045093]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - US FDA's revised consumption factor for polystyrene used in food-contact applications.
AN  - 68146477; 17691017
AB  - US FDA's continual effort to evaluate the safety of food-contact materials includes periodically re-examining our established packaging factors, such as consumption and food-type distribution factors. The use of polystyrene in food-contact and disposable food-packaging applications has expanded and is expected to continue to increase in the future. Therefore, it is important to revise the polystyrene consumption factor to account for increases in consumer exposure to substances migrating from styrenic food packaging. The currently used consumption factor for polystyrene is 0.1, which is based on market data collected around 1980. US FDA has revised the polystyrene consumption factor utilizing three different sources of market data. Using consumption and population data, US FDA calculated a new consumption factor of 0.14 for polystyrene. This consumption factor has been further subdivided to allow for the refinement of exposure estimates for uses limited to specific subcategories of polystyrene packaging.
JF  - Food additives and contaminants
AU  - Cassidy, K
AU  - Elyashiv-Barad, S
AD  - Division of Food Contact Notifications, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA.
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 1026
EP  - 1031
VL  - 24
IS  - 9
SN  - 0265-203X, 0265-203X
KW  - Environmental Pollutants
KW  - 0
KW  - Polystyrenes
KW  - Index Medicus
KW  - United States
KW  - Food Contamination -- prevention & control
KW  - Humans
KW  - Food Contamination -- legislation & jurisprudence
KW  - Environmental Exposure -- legislation & jurisprudence
KW  - Diet
KW  - Environmental Exposure -- adverse effects
KW  - Environmental Pollutants -- administration & dosage
KW  - Environmental Pollutants -- adverse effects
KW  - Household Articles
KW  - Food Packaging -- standards
KW  - Polystyrenes -- adverse effects
KW  - United States Food and Drug Administration -- legislation & jurisprudence
KW  - Polystyrenes -- administration & dosage
KW  - Food Packaging -- legislation & jurisprudence
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-25
N1  - Date created - 2007-08-10
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Acute toxicity of sodium arsenite in a complex food matrix.
AN  - 68110374; 17418926
AB  - Acute toxicity of a single oral dose of sodium arsenite (As), administered in half and half cream (HH), was assessed in male and non-pregnant female rats (0.41, 4.1, 41.0 and 410.0mg/kg body weight) and pregnant rats (0.41, 4.1 and 41.0mg/kg body weight). Control rats received deionized water alone, HH alone or 41.0mg/kg As in deionized water (41 mg/kg As-water). Male and non-pregnant rats were monitored for 14 consecutive days post-dosing. Pregnant rats, dosed on gestation day 10 (GD-10), were monitored until fetuses were collected on GD 20. High mortality (100%) was observed in male and non-pregnant female rats exposed to 410.0mg/kg As-HH. Low mortality (25%) was observed in non-pregnant female rats exposed to 41 mg/kg As-water. No mortality was observed in other control or treated groups. Reduced female fetal numbers were observed in the 41 mg/kg As-water group but not in the other control groups. Developmental effects were not observed in the controls or the As-HH treatment groups. In conclusion, As toxicity was not reduced when a high dose (410 mg/kg) was administered in HH however, at lower doses (41 mg/kg), HH reduced acute As oral toxicity in the female and developing fetus.
JF  - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
AU  - Sprando, R L
AU  - Collins, T F X
AU  - Black, T
AU  - Olejnik, N
AU  - Ramos-Valle, M
AU  - Ruggles, D
AD  - Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, 8301 Muirkirk Road, Laurel, MD 20708, United States. rsprando@cfsan.fda.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 1606
EP  - 1613
VL  - 45
IS  - 9
SN  - 0278-6915, 0278-6915
KW  - Arsenites
KW  - 0
KW  - Dietary Fats
KW  - Enzyme Inhibitors
KW  - Sodium Compounds
KW  - Water
KW  - 059QF0KO0R
KW  - sodium arsenite
KW  - 48OVY2OC72
KW  - Index Medicus
KW  - Administration, Oral
KW  - Animals
KW  - Dose-Response Relationship, Drug
KW  - Fetal Resorption -- pathology
KW  - Gestational Age
KW  - Fetal Resorption -- chemically induced
KW  - Pregnancy
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Survival Rate
KW  - Toxicity Tests, Acute
KW  - Water -- pharmacology
KW  - Female
KW  - Male
KW  - Dietary Fats -- pharmacology
KW  - Sodium Compounds -- administration & dosage
KW  - Fetus -- drug effects
KW  - Fetus -- embryology
KW  - Enzyme Inhibitors -- administration & dosage
KW  - Enzyme Inhibitors -- toxicity
KW  - Arsenites -- toxicity
KW  - Sodium Compounds -- toxicity
KW  - Food Contamination
KW  - Arsenites -- administration & dosage
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-03
N1  - Date created - 2007-08-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Explaining Mental Health Treatment Disparities: Ethnic and Cultural Differences in Family Involvement
AN  - 61682748; 200806506
AB  - In a large, representative sample of persons receiving public mental health treatment, we examined whether ethnic minority consumers were more likely than white consumers to live with their families and to receive family support. We then evaluated whether differences observed in family involvement explained treatment disparities observed in outpatient and inpatient mental health services. Results indicated that Asian American and Latino consumers, especially, were considerably more likely than white consumers to live with family members and to receive family support. Ethnocultural differences in living with family did explain treatment intensity disparities whether or not consumers described themselves as dependent on family support. The results support the hypothesis that cultural differences in family involvement and support play a role in explaining mental health treatment disparities. Adapted from the source document.
JF  - Culture, Medicine and Psychiatry
AU  - Snowden, Lonnie R
AD  - Center for Mental Health Services Research, School of Social Welfare, University of California, Berkeley, Berkeley, CA 94720, USA snowden@berkeley.edu
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 389
EP  - 402
PB  - Springer, Dordrecht The Netherlands
VL  - 31
IS  - 3
SN  - 0165-005X, 0165-005X
KW  - Minority Groups
KW  - Ethnic Groups
KW  - Sociocultural Factors
KW  - Family Life
KW  - Racial Differences
KW  - Mental Health Services
KW  - Treatment
KW  - article
KW  - 2046: sociology of health and medicine; social psychiatry (mental health)
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LA  - English
DB  - Sociological Abstracts
N1  - Date revised - 2008-03-04
N1  - Number of references - 25
N1  - Last updated - 2016-09-28
N1  - CODEN - CMPSD2
N1  - SubjectsTermNotLitGenreText - Mental Health Services; Treatment; Racial Differences; Family Life; Sociocultural Factors; Ethnic Groups; Minority Groups
DO  - http://dx.doi.org/10.1007/s11013-007-9057-z
ER  - 



TY  - JOUR
T1  - Evolution of the Special Projects of National Significance Prevention with HIV-Infected Persons Seen in Primary Care Settings Initiative
AN  - 61408497; 200802102
AB  - Abstract not available.
JF  - AIDS and Behavior
AU  - Malitz, Faye E
AU  - Eldred, Lois
AD  - HIV/AIDS Bureau, Health Resources and Services Administration, Rockville, USA fmalitz@hrsa.gov
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 1
EP  - 5
PB  - Springer, Dordrecht, The Netherlands
VL  - 11
IS  - Supplement 1
SN  - 1090-7165, 1090-7165
KW  - Prevention
KW  - Acquired Immune Deficiency Syndrome
KW  - Health Care Services
KW  - article
KW  - 6126: acquired immune deficiency syndrome (AIDS)
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LA  - English
DB  - Social Services Abstracts
N1  - Date revised - 2008-04-02
N1  - Number of references - 22
N1  - Last updated - 2016-09-28
N1  - CODEN - AIBEFC
N1  - SubjectsTermNotLitGenreText - Prevention; Health Care Services; Acquired Immune Deficiency Syndrome
DO  - http://dx.doi.org/10.1007/s10461-007-9252-5
ER  - 



TY  - JOUR
T1  - Pediatrician Perspectives on Children's Access to Mental Health Services: Consequences and Potential Solutions
AN  - 61402425; 200801024
AB  - This paper examines pediatricians' perspectives regarding access to children's mental health care. In response to a question about factors that help or hinder coordination of care 190 respondents voluminously wrote about mental health access barriers. Responses were qualitatively analyzed to understand pediatricians' perspectives. Four thematic areas emerged: Insurance issues, availability of mental health specialty providers, state mental health systems, and pediatricians' attempts to improve access to mental health services. Pediatricians' responses included educating themselves, using telemedicine, and hiring co-located mental health specialists. Recommendations are made to address pediatricians' treatment of children with mental illnesses and their access to treatment resources. Adapted from the source document.
JF  - Administration and Policy in Mental Health AND Mental Health Services Research
AU  - Pfefferle, Susan G
AD  - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, 4 Brookings Dr., Campus Box 1093, St. Louis, MO 63130, USA spfefferle@gwbmail.wustl.edu
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 425
EP  - 434
PB  - Springer, Dordrecht The Netherlands
VL  - 34
IS  - 5
SN  - 0894-587X, 0894-587X
KW  - Child and adolescent mental health, Mental health policy, Pediatrics, Access
KW  - Constraints
KW  - Specialists
KW  - Access
KW  - Mental Health Services
KW  - Children
KW  - article
KW  - 6143: child & family welfare
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LA  - English
DB  - Social Services Abstracts
N1  - Date revised - 2008-02-04
N1  - Last updated - 2016-09-28
N1  - CODEN - APMHEM
N1  - SubjectsTermNotLitGenreText - Mental Health Services; Access; Children; Specialists; Constraints
DO  - http://dx.doi.org/10.1007/s10488-007-0122-2
ER  - 



TY  - BOOK
T1  - Mining Facts 2004
AN  - 58774182; 2008-150288
AB  - Gives statistics for employment, fatalities and injuries in the mining industry in 2004. Tables, Figures, References.
JF  - United States National Institute for Occupational Safety and Health (NIOSH), Sep 2007, 4 pp.
AU  - National Institute Occupational Safety and Health
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
EP  - 4p
PB  - United States National Institute for Occupational Safety and Health (NIOSH)
KW  - Labor conditions and policy - Employment and labor supply
KW  - Science and technology policy - Biology and biotechnology
KW  - Social conditions and policy - Public safety and security
KW  - Environment and environmental policy - Mining and mineral resources
KW  - Accidents
KW  - Death
KW  - Personal injuries
KW  - Miners
KW  - Employment
KW  - Mining industry
KW  - book
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58774182?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Institute+Occupational+Safety+and+Health&rft.aulast=National+Institute+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=4p&rft.isbn=&rft.btitle=Mining+Facts+2004&rft.title=Mining+Facts+2004&rft.issn=&rft_id=info:doi/
L2  - http://www.cdc.gov/niosh/mining/pubs/pdfs/2007-166.pdf
LA  - English
DB  - PAIS Index
N1  - Date revised - 2008-06-04
N1  - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007
N1  - SuppNotes - NIOSH Publication No. 2007-166
N1  - Last updated - 2016-09-28
ER  - 



TY  - BOOK
T1  - Reducing Pesticide Exposure at Schools
AN  - 58762521; 2008-150287
AB  - Pesticides play an important role in food supply protection and disease control, but they can also be harmful to human health. The term pesticide applies to insecticides, herbicides, fungicides, disinfectants and various other substances used to control pests. Pesticides are often applied at schools to help maintain sanitary conditions and suppress rodents and insect populations. Exposures and potential health risks to children and school staff can be reduced by avoiding routine pesticide applications through an Integrated Pest Management (IPM) program. Figures, References.
JF  - United States National Institute for Occupational Safety and Health (NIOSH), Sep 2007, 4 pp.
AU  - National Inst Occupational Safety and Health
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
EP  - 4p
PB  - United States National Institute for Occupational Safety and Health (NIOSH)
KW  - Education and education policy - Schools
KW  - Environment and environmental policy - Radioactive and dangerous substances
KW  - Schools
KW  - Hazardous materials
KW  - Pesticides
KW  - book
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58762521?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Inst+Occupational+Safety+and+Health&rft.aulast=National+Inst+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=4p&rft.isbn=&rft.btitle=Reducing+Pesticide+Exposure+at+Schools&rft.title=Reducing+Pesticide+Exposure+at+Schools&rft.issn=&rft_id=info:doi/
L2  - http://www.cdc.gov/niosh/docs/2007-150/pdfs/2007-150.pdf
LA  - English
DB  - PAIS Index
N1  - Date revised - 2008-06-04
N1  - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007
N1  - SuppNotes - Niosh Publication No. 2007-150
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - Area Under the Curve and Other Summary Indicators of Repeated Waking Cortisol Measurements
AN  - 57314145; 200811472
AB  - Objective: To derive the area under the curve and related summary measures of stress from saliva samples collected over time and to provide insight into the interpretation of the derived parameters. In research designed to assess the health consequences of stress these samples are often used as a physiologic indicator of the responsiveness of the hypothalamic-pituitary-adrenal (HPA) axis. To make these repeated measurements of salivary cortisol more useful in defining the relationships between stress and health there is a need to derive two forms of area under the curve that summarize the measurements: area under the curve with respect to ground (AUCG) and area under the curve with respect to increase (AUCI). The latter parameters, AUCI, however, is seldom used by research scientists. Methods: In this study, interpretation and generic definition of the area under the curve was provided through graphical analyses and examination of its association with other summary measures using data from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Pilot Study. In generic form, AUCI is derived as the area under the curve above the baseline value minus the area above the curve below the baseline value. Results: The sign and magnitude of AUCI are related to the profile and the rate of change of the measurements over time. The parameter showed significant associations with other summary indicators that measure pattern or rate of change of the measurements over time. Conclusion: Principal components analyses revealed that summary parameters derived from repeated cortisol measurements can be grouped into two meaningful general categories: measures of the magnitude of response and measures of the pattern of response over time. Adapted from the source document.
JF  - Psychosomatic Medicine
AU  - Fekedulegn, Desta B
AU  - Andrew, Michael E
AU  - Burchfiel, Cecil M
AU  - Violanti, John M
AU  - Hartley, Tara A
AU  - Charles, Luenda E
AU  - Miller, Diane B
AD  - Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, HELD/BEB, MS 4050, 1095 Willowdale Rd., Morgantown, WV 26505
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 651
EP  - 659
PB  - Lippincott Williams & Wilkins, Philadelphia PA
VL  - 69
IS  - 7
SN  - 0033-3174, 0033-3174
KW  - repeated cortisol measurements, area under the curve, principal component analysis, total hormonal secretion, time course of salivary cortisol
KW  - Parameters
KW  - Measurement
KW  - Magnitude
KW  - Cortisol
KW  - Salivary cortisol
KW  - Stress
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57314145?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Area+Under+the+Curve+and+Other+Summary+Indicators+of+Repeated+Waking+Cortisol+Measurements&rft.au=Fekedulegn%2C+Desta+B%3BAndrew%2C+Michael+E%3BBurchfiel%2C+Cecil+M%3BViolanti%2C+John+M%3BHartley%2C+Tara+A%3BCharles%2C+Luenda+E%3BMiller%2C+Diane+B&rft.aulast=Fekedulegn&rft.aufirst=Desta&rft.date=2007-09-01&rft.volume=69&rft.issue=7&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/10.1097%2FPSY.0b013e31814c405c
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2010-02-03
N1  - Last updated - 2016-09-27
N1  - CODEN - PSMEAP
N1  - SubjectsTermNotLitGenreText - Measurement; Stress; Parameters; Magnitude; Cortisol; Salivary cortisol
DO  - http://dx.doi.org/10.1097/PSY.0b013e31814c405c
ER  - 



TY  - JOUR
T1  - Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study
AN  - 57216321; 200803987
AB  - Background: Despite increasing awareness of the extent and severity of cognitive deficits in major depressive disorder (MDD), trials of cognitive remediation have not been conducted. We conducted a 10-week course of cognitive remediation in patients with long-term MDD to probe whether deficits in four targeted cognitive domains, (i) memory, (ii) attention, (iii) executive functioning and (iv)psychomotor speed, could be improved by this intervention. Method: We administered a computerized cognitive retraining package (PSSCogReHab) with demonstrated efficacy to 12 stable patients with recurrent MDD. Twelve matched patients with MDD and a group of healthy control participants were included for comparison; neither comparator group received the intervention that involved stimulation of cognitive functions through targeted, repetitive exercises in each domain. Results: Patients who received cognitive training improved on a range of neuropsychological tests targeting attention, verbal learning and memory, psychomotor speed and executive function. This improvement exceeded that observed over the same time period in a group of matched comparisons. There was no change in depressive symptom scores over the course of the trial, thus improvement in cognitive performance occurred independent of other illness variables. Conclusions: These results provide preliminary evidence that improvement of cognitive functions through targeted, repetitive exercises is a viable method of cognitive remediation in patients with recurrent MDD. Adapted from the source document.
JF  - Psychological Medicine
AU  - Elgamal, Safa
AU  - McKinnon, Margaret C
AU  - Ramakrishnan, Karun
AU  - Joffe, Russell T
AU  - MacQueen, Glenda
AD  - St Joseph's Center for Mental Health Services, DI, Mood Disorders Program, 100 West 5th St, Hamilton, ON, Canada L8N 3K7
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 1229
EP  - 1238
PB  - Cambridge University Press, UK
VL  - 37
IS  - 9
SN  - 0033-2917, 0033-2917
KW  - Memory
KW  - Cognitive deficits
KW  - Depression
KW  - Computer assisted training
KW  - Attention
KW  - Executive function
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57216321?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Successful+computer-assisted+cognitive+remediation+therapy+in+patients+with+unipolar+depression%3A+a+proof+of+principle+study&rft.au=Elgamal%2C+Safa%3BMcKinnon%2C+Margaret+C%3BRamakrishnan%2C+Karun%3BJoffe%2C+Russell+T%3BMacQueen%2C+Glenda&rft.aulast=Elgamal&rft.aufirst=Safa&rft.date=2007-09-01&rft.volume=37&rft.issue=9&rft.spage=1229&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291707001110
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-03-04
N1  - Last updated - 2016-09-27
N1  - CODEN - PSMDCO
N1  - SubjectsTermNotLitGenreText - Depression; Computer assisted training; Cognitive deficits; Attention; Memory; Executive function
DO  - http://dx.doi.org/10.1017/S0033291707001110
ER  - 



TY  - JOUR
T1  - Numerical analysis of the influence of in-seam horizontal methane drainage boreholes on longwall face emission rates
AN  - 51232140; 2008-075295
AB  - High methane emissions originating from the active face areas and from the fractured formations overlying and underlying the mined coalbed can adversely affect both safety and productivity in underground coal mines. Since ventilation alone may not be sufficient to control the methane levels in the longwall mining environment, gob gas ventholes have become a standard supplementary methane control option in many mines. As mines progress into deeper and gassier coalbeds, or as longwall panel size increases, ventilation and gob gas ventholes together may not be sufficient to maintain methane levels within statutory limits. To decrease the risk associated with methane emissions under these circumstances, in-seam horizontal methane drainage is often used to reduce the gas content of the coalbed prior to mining. Horizontal methane drainage borehole completion designs, drilling strategies, and degasification lead times may need to be adjusted for site-specific conditions due to mine design, geology, and the gas content of the coalbed. This study investigates different horizontal methane drainage borehole patterns, borehole lengths, and degasification times prior to and during panel extraction to evaluate their effectiveness in reducing methane emissions using a "dynamic" 3D reservoir modeling of a 381-m wide longwall panel operating in the Pittsburgh coalbed. Results of this study showed that dual and tri-lateral boreholes are more effective in decreasing emissions and in shielding the entries compared to fewer shorter, cross-panel, horizontal boreholes parallel to the longwall face. Modeling results showed that after 12 months of pre-mining methane drainage, the average longwall face emission rates can be reduced by as much as 10.3 m (super 3) /min and 6.8 m (super 3) /min using tri- and dual-lateral boreholes, respectively. It was also shown that if pre-mining methane drainage time is short, it is important to continue methane drainage during the panel extraction to maximize reductions in longwall face emissions since additional face emission reductions achieved during this period can be comparable to pre-mining degasification.
JF  - International Journal of Coal Geology
AU  - Karacan, C O
AU  - Diamond, W P
AU  - Schatzel, S J
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 15
EP  - 32
PB  - Elsevier, Amsterdam
VL  - 72
IS  - 1
SN  - 0166-5162, 0166-5162
KW  - mining
KW  - mines
KW  - degasification
KW  - underground mining
KW  - numerical analysis
KW  - natural gas
KW  - drainage
KW  - data processing
KW  - coal mines
KW  - petroleum
KW  - coal seams
KW  - preventive measures
KW  - safety
KW  - longwall mining
KW  - boreholes
KW  - mining geology
KW  - digital simulation
KW  - coalbed methane
KW  - 29A:Economic geology, geology of energy sources
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51232140?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Numerical+analysis+of+the+influence+of+in-seam+horizontal+methane+drainage+boreholes+on+longwall+face+emission+rates&rft.au=Karacan%2C+C+O%3BDiamond%2C+W+P%3BSchatzel%2C+S+J&rft.aulast=Karacan&rft.aufirst=C&rft.date=2007-09-01&rft.volume=72&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2006.12.007
L2  - http://www.sciencedirect.com/science/journal/01665162
LA  - English
DB  - GeoRef
N1  - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands
N1  - Date revised - 2008-01-01
N1  - Number of references - 29
N1  - Document feature - illus. incl. 5 tables
N1  - Last updated - 2012-06-07
N1  - SubjectsTermNotLitGenreText - boreholes; coal mines; coal seams; coalbed methane; data processing; degasification; digital simulation; drainage; longwall mining; mines; mining; mining geology; natural gas; numerical analysis; petroleum; preventive measures; safety; underground mining
DO  - http://dx.doi.org/10.1016/j.coal.2006.12.007
ER  - 



TY  - CPAPER
T1  - Universal Virus Detection.
T2  - 3rd European Congress of Virology
AN  - 39558919; 4649857
JF  - 3rd European Congress of Virology
AU  - Uhlenhaut, Christine
AU  - Nanda, Santosh
AU  - Sierra-Honigmann, Ana
AU  - Krause, Philip R
Y1  - 2007/09/01/
PY  - 2007
DA  - 2007 Sep 01
KW  - Polymerase chain reaction
KW  - Nucleotide sequence
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39558919?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+European+Congress+of+Virology&rft.atitle=Universal+Virus+Detection.&rft.au=Uhlenhaut%2C+Christine%3BNanda%2C+Santosh%3BSierra-Honigmann%2C+Ana%3BKrause%2C+Philip+R&rft.aulast=Uhlenhaut&rft.aufirst=Christine&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+European+Congress+of+Virology&rft.issn=&rft_id=info:doi/
L2  - http://www.eurovirology.org/program.html
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Suppression of EBV Encoded microRNA Abrogates Viral Infection.
T2  - 3rd European Congress of Virology
AN  - 39449225; 4649724
JF  - 3rd European Congress of Virology
AU  - Avni, Yonat Shemer
AU  - Keren-Naus, Ayelet
AU  - Tsurumi, Tatsuya
AU  - Ayzenberg, Natalie
AU  - Meiri, Eti
AU  - Barda, Einat
AU  - Bentwich, Zvi
Y1  - 2007/09/01/
PY  - 2007
DA  - 2007 Sep 01
KW  - Infection
KW  - MiRNA
KW  - Viral diseases
KW  - Epstein-Barr virus
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39449225?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+European+Congress+of+Virology&rft.atitle=Suppression+of+EBV+Encoded+microRNA+Abrogates+Viral+Infection.&rft.au=Avni%2C+Yonat+Shemer%3BKeren-Naus%2C+Ayelet%3BTsurumi%2C+Tatsuya%3BAyzenberg%2C+Natalie%3BMeiri%2C+Eti%3BBarda%2C+Einat%3BBentwich%2C+Zvi&rft.aulast=Avni&rft.aufirst=Yonat&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+European+Congress+of+Virology&rft.issn=&rft_id=info:doi/
L2  - http://www.eurovirology.org/program.html
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Effect of different Vaccination Schedules on the Excretion and Reversion of Attenuated Poliovirus.
T2  - 3rd European Congress of Virology
AN  - 39411896; 4650110
JF  - 3rd European Congress of Virology
AU  - Laassri, Majid
AU  - Lottenbach, Kathleen
AU  - Belshe, Robert
AU  - Plotkin, Stanley
AU  - Chumakov, Konstantin
Y1  - 2007/09/01/
PY  - 2007
DA  - 2007 Sep 01
KW  - Excretion
KW  - Vaccination
KW  - Reversion
KW  - Poliovirus
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39411896?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+European+Congress+of+Virology&rft.atitle=Effect+of+different+Vaccination+Schedules+on+the+Excretion+and+Reversion+of+Attenuated+Poliovirus.&rft.au=Laassri%2C+Majid%3BLottenbach%2C+Kathleen%3BBelshe%2C+Robert%3BPlotkin%2C+Stanley%3BChumakov%2C+Konstantin&rft.aulast=Laassri&rft.aufirst=Majid&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+European+Congress+of+Virology&rft.issn=&rft_id=info:doi/
L2  - http://www.eurovirology.org/program.html
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Infections and human tissue transplants: review of FDA MedWatch reports 2001-2004
AN  - 20725522; 8310675
AB  - Background: More than 1.5 million tissue allografts are transplanted annually in the U.S. As part of the federal effort to improve tissue safety, FDA's May 2005 Current Good Tissue Practices (CGTP) Rule requires tissue establishments to report to FDA serious infectious adverse events following allograft transplantation. To provide baseline data, we summarize reports of such infections received by FDA prior to the CGTP Rule. Methods: We reviewed reports received by FDA's MedWatch adverse event reporting system during 2001-2004. Our case definition was a reported infection in a human tissue transplant recipient within 1 year of transplantation. We examined demographics, tissue type, clinical outcomes and interventions, infectious organism(s), time from transplant to infection and reporter characteristics. Results: We identified 83 reports of infections following allograft transplantations. Median patient age was 40 years (range: 1 month-87 years). The allografts included heart valves (42%), tendons (33%), bones (8%), blood vessels (6%), ocular tissues (5%), and skin (4%). Commonly reported outcomes and interventions were hospitalization (72%), antibiotic therapy (46%) and graft removal (42%). Nine of 11 patients who expired had received heart valves. In 65 reports that identified suspected organisms, bacteria were most common (42), followed by fungi (25) and prions (1). The median time from transplant to infection was 5.5 weeks (range: 3 days-52 weeks). Tissue manufacturers submitted 26% of reports. Among the remaining 74%, the reporters were quality assurance staff, infection control or risk management personnel (45%); physicians (15%); consumers (15%); nurses (13%); and surgical staff (12%). Conclusion: This is the first review of reports to FDA for infections following allograft tissue transplantations. Infections led to serious outcomes and involved many tissue types. Although we were unable to confirm that reported infections were caused by the suspected tissue product, required reporting by tissue establishments and improvements in adverse event investigation will help to improve tissue safety surveillance.
JF  - Cell and Tissue Banking
AU  - Wang, Su
AU  - Zinderman, Craig
AU  - Wise, Robert
AU  - Braun, Miles
AD  - U.S. Food and Drug Administration/Center for Biologics Evaluation and Research/Office of Biostatistics and Epidemiology, 1401 Rockville Pike, Rockville, MD, 20852, USA, Craig.zinderman@fda.hhs.gov
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 211
EP  - 219
PB  - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/]
VL  - 8
IS  - 3
SN  - 1389-9333, 1389-9333
KW  - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts
KW  - Heart
KW  - Age
KW  - Skin
KW  - Data processing
KW  - Fungi
KW  - Heart transplantation
KW  - Antibiotics
KW  - Infection
KW  - Demography
KW  - Bone
KW  - Blood vessels
KW  - Personnel
KW  - Reviews
KW  - Quality control
KW  - Prion protein
KW  - Consumers
KW  - Tendons
KW  - K 03400:Human Diseases
KW  - W 30920:Tissue Engineering
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20725522?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+and+Tissue+Banking&rft.atitle=Infections+and+human+tissue+transplants%3A+review+of+FDA+MedWatch+reports+2001-2004&rft.au=Wang%2C+Su%3BZinderman%2C+Craig%3BWise%2C+Robert%3BBraun%2C+Miles&rft.aulast=Wang&rft.aufirst=Su&rft.date=2007-09-01&rft.volume=8&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Cell+and+Tissue+Banking&rft.issn=13899333&rft_id=info:doi/10.1007%2Fs10561-007-9034-3
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Heart; Age; Data processing; Skin; Fungi; Heart transplantation; Antibiotics; Infection; Bone; Demography; Blood vessels; Personnel; Quality control; Reviews; Prion protein; Consumers; Tendons
DO  - http://dx.doi.org/10.1007/s10561-007-9034-3
ER  - 



TY  - JOUR
T1  - Alcohol, Smoking, and Body Size in Relation to Incident Hodgkin's and Non-Hodgkin's Lymphoma Risk
AN  - 20723319; 7554738
AB  - Studies associate alcohol consumption, cigarette smoking, and body size with the risk of overall or subtype lymphoma. Current data come mostly from case-control studies or prospective studies with few cases. In the prospective National Institutes of Health-former American Association of Retired Persons (NIH-AARP) Diet and Health Study, the authors assessed the above lifestyle factors via baseline questionnaire among 285,079 men and 188,905 women aged 50-71 years and ascertained histologically confirmed Hodgkin's lymphoma (n = 58) and non-Hodgkin's lymphoma (n = 1,381) cases through linkage with cancer registries from 1995 to 2000. Compared with nondrinkers, alcohol consumers had a lower risk for non-Hodgkin's lymphoma overall (for >28 drinks/week: adjusted relative risk (RR) = 0.77, 95% confidence interval (CI): 0.59, 1.00; p sub(trend) among drinkers = 0.02) and for its main subtypes. Compared with never smokers, current smokers and recent quitters ( less than or equal to 4 years ago) had higher risk of Hodgkin's lymphoma (RR = 2.25, 95% CI: 1.04, 4.89; RR = 4.20, 95% CI: 1.94, 9.09, respectively), whereas current or former smokers had lower risk of follicular non-Hodgkin's lymphoma (RR = 0.67, 95% CI: 0.52, 0.86). Severe obesity (body mass index of greater than or equal to 35: RR = 1.29, 95% CI: 1.02, 1.64) and taller height (RR = 1.19, 95% CI: 1.03, 1.38) were associated moderately with non-Hodgkin's lymphoma. These findings add to the evidence that lifestyle factors and relevant anthropometric characteristics play a role in lymphoma etiology.
JF  - American Journal of Epidemiology
AU  - Lim, Unhee
AU  - Morton, Lindsay M
AU  - Subar, Amy F
AU  - Baris, Dalsu
AU  - Stolzenberg-Solomon, Rachael
AU  - Leitzmann, Michael
AU  - Kipnis, Victor
AU  - Mouw, Traci
AU  - Carroll, Leslie
AU  - Schatzkin, Arthur
AU  - Hartge, Patricia
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 697
EP  - 708
PB  - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 166
IS  - 6
SN  - 0002-9262, 0002-9262
KW  - Risk Abstracts; Immunology Abstracts; Toxicology Abstracts
KW  - non-Hodgkin's lymphoma
KW  - Risk assessment
KW  - Hodgkin's disease
KW  - obesity
KW  - body size
KW  - Non-Hodgkin's lymphoma
KW  - body mass
KW  - Risk factors
KW  - Cigarette smoking
KW  - Body size
KW  - Consumers
KW  - Ethanol
KW  - Diets
KW  - Alcohol
KW  - Inventories
KW  - Obesity
KW  - Etiology
KW  - Beverages
KW  - Data processing
KW  - Cancer
KW  - Body mass index
KW  - lymphoma
KW  - X 24380:Social Poisons & Drug Abuse
KW  - F 06915:Cancer Immunology
KW  - R2 23060:Medical and environmental health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Diets; Risk assessment; Obesity; Inventories; Etiology; Data processing; Hodgkin's disease; Beverages; Cancer; Non-Hodgkin's lymphoma; Risk factors; Cigarette smoking; Body size; Consumers; Body mass index; Ethanol; non-Hodgkin's lymphoma; Alcohol; body mass; obesity; body size; lymphoma
ER  - 



TY  - JOUR
T1  - Emergence of a Virulent Clade of Vibrio vulnificus and Correlation with the Presence of a 33-Kilobase Genomic Island
AN  - 20614316; 7554105
AB  - Vibrio vulnificus is a ubiquitous inhabitant of the marine coastal environment, and an important pathogen of humans. We characterized a globally distributed sample of environmental isolates from a range of habitats and hosts and compared these with isolates recovered from cases of human infection. Multilocus sequence typing data using six housekeeping genes divided 63 of the 67 isolates into the two main lineages previously noted for this species, and this division was also confirmed using the 16S rRNA and open reading frame VV0401 markers. Lineage I was comprised exclusively of biotype 1 isolates, whereas lineage II contained biotype 1 and all biotype 2 isolates. Four isolates did not cluster within either lineage: two biotype 3 and two biotype 1 isolates. The proportion of isolates recovered from a clinical setting was noted to be higher in lineage I than in lineage II. Lineage I isolates were also associated with a 33-kb genomic island (region XII), one of three regions identified by genome comparisons as unique to the species. Region XII contained an arylsulfatase gene cluster, a sulfate reduction system, two chondroitinase genes, and an oligopeptide ABC transport system, all of which are absent from the majority of lineage II isolates. Arylsulfatases and the sulfate reduction system, along with performing a scavenging role, have been hypothesized to play a role in pathogenic processes in other bacteria. Our data suggest that lineage I may have a higher pathogenic potential and that region XII, along with other regions, may give isolates a selective advantage either in the human host or in the aquatic environment or both.
JF  - Applied and Environmental Microbiology
AU  - Cohen, Ana Luisa V
AU  - Oliver, James D
AU  - DePaola, Angelo
AU  - Feil, Edward J
AU  - Fidelma Boyd, E
AD  - Department of Biological Sciences, University of Delaware, Newark, Delaware 19716. Department of Microbiology, National University of Ireland, Cork, Ireland. Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223. Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, Alabama 36528. Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
Y1  - 2007/09/01/
PY  - 2007
DA  - 2007 Sep 01
SP  - 5553
EP  - 5565
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA
VL  - 73
IS  - 17
SN  - 0099-2240, 0099-2240
KW  - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources
KW  - Genomes
KW  - Marine
KW  - Biotypes
KW  - Coastal environments
KW  - Pathogenic bacteria
KW  - Sulfate reduction
KW  - Bacterial diseases
KW  - Arylsulfatase
KW  - Pathogens
KW  - Infection
KW  - Habitat
KW  - Aquatic environment
KW  - multilocus sequence typing
KW  - Public health
KW  - Coastal zone
KW  - Vibrio vulnificus
KW  - Microorganisms
KW  - genomics
KW  - Oligopeptides
KW  - rRNA 16S
KW  - Open reading frames
KW  - J 02310:Genetics & Taxonomy
KW  - Q1 08484:Species interactions: parasites and diseases
KW  - Q5 08524:Public health, medicines, dangerous organisms
KW  - G 07770:Bacteria
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2016-05-27
N1  - SubjectsTermNotLitGenreText - Genomes; Coastal zone; Pathogenic bacteria; Bacterial diseases; Microorganisms; Public health; Biotypes; Coastal environments; Sulfate reduction; Arylsulfatase; Pathogens; Habitat; Infection; Aquatic environment; multilocus sequence typing; genomics; rRNA 16S; Oligopeptides; Open reading frames; Vibrio vulnificus; Marine
ER  - 



TY  - JOUR
T1  - Regional Differences in African Americans' High Risk for Stroke: The Remarkable Burden of Stroke for Southern African Americans
AN  - 20561267; 9271085
AB  - Purpose The stroke mortality rate for African Americans aged 45 to 64 years is 3 to 4 times higher than for whites of the same age, with a decreasing black-to-white mortality ratio with increasing age. There is also a 'STROKE BELT' with higher stroke mortality in the southeastern United States. This study assesses if there are also geographic variations in the magnitude of the excess stroke mortality for African Americans. Methods The age- and sex-specific black-to-white mortality ratio was calculated for each of 26 states with a sufficient African American population for stable estimates. The southern excess was calculated as the percentage excess of southern over nonsouthern rates. Results Across age and sex strata, the black-to-white stroke mortality ratio was consistently higher for southern states, with an average black-to-white stroke mortality ratio that ranged from 6% to 21% higher among southern states than in nonsouthern states. Conclusions The increase in stroke mortality rates for African Americans in southern states is even larger than expected. That southern states that are not part of the 'STROKE BELT' (Virginia and Florida) also have an elevated black-to-white mortality ratio suggests the mechanism of higher risk for African Americans may be independent of the causes contributing to 'STROKE BELT.' Key Words: Cerebrovascular Accident; Mortality; Continental Population Groups; African Americans; Geography
JF  - Annals of Epidemiology
AU  - Howard, George
AU  - Labarthe, Darwin R
AU  - Hu, Jianfang
AU  - Yoon, Sarah
AU  - Howard, Virginia J
AD  - From the University of Alabama School of Public Health, Departments of Biostatistics (G.H., J.H.) and Epidemiology (V.J.H.), Birmingham; and the Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA (D.R.L., S.Y.), ghoward@uab.edu
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 689
EP  - 696
PB  - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com]
VL  - 17
IS  - 9
SN  - 1047-2797, 1047-2797
KW  - Risk Abstracts
KW  - stroke
KW  - Mortality
KW  - Age
KW  - Accidents
KW  - USA, Florida
KW  - Africa
KW  - USA, Virginia
KW  - USA, Southeast
KW  - Geography
KW  - Ethnic groups
KW  - R2 23060:Medical and environmental health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-05-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Mortality; stroke; Accidents; Age; Geography; Ethnic groups; USA, Florida; Africa; USA, Virginia; USA, Southeast
ER  - 



TY  - JOUR
T1  - Relative and Combined Performance of Mammography and Ultrasonography for Breast Cancer Screening in the General Population: a Pilot Study in Tochigi Prefecture, Japan
AN  - 20404967; 7743412
AB  - BACKGROUND: Breast cancer screening by mammography is thought to be effective in reducing breast cancer mortality while ultrasonography is not accepted as a population screening modality, although the latter has been suggested to be useful in detection of cancer in the dense breast, relatively more typical for a younger woman. METHODS: Mammography with medio-lateral oblique view was offered on trial in 1999-2000 for 3453 female residents in Tochigi prefecture who also underwent clinical breast examination and ultrasonography. The municipalities that provided cancer screening were informed of the final diagnosis for women with positive findings in the screening trial by doctors who performed the diagnostic evaluation. Linkage was also made between the list of participants in the trial and registrations at Tochigi Cancer Registry for breast cancer cases diagnosed during 1999-2001. RESULTS: Thirteen cases with breast cancer were identified during a 2-year follow-up period: 10 were diagnosed subsequent to positive finding in the trial; two were negative in the trial and diagnosed 23 and 24 months after, respectively; and one had a positive finding at the trial but was undiagnosed at first and then diagnosed 18 months after the trial. Among the 11 cases judged as positive in the trial, four were judged only by mammography while three were judged only by ultrasonography. Those mammography alone-detected cases were relatively young, at 36, 40, 47 and 54 years of age, respectively, while the ultrasonography alone-detected cases were aged 50, 55 and 68, respectively. CONCLUSIONS: Combined screening with mammography and ultrasonography may be feasible. A larger study is required to evaluate relative performance of mammography and ultrasonography in detail by characteristics of examinees and their breasts.
JF  - Japanese Journal of Clinical Oncology
AU  - Honjo, Satoshi
AU  - Ando, Jiro
AU  - Tsukioka, Takeo
AU  - Morikubo, Hiroshi
AU  - Ichimura, Miyuki
AU  - Sunagawa, Masakatsu
AU  - Hasegawa, Toshihiko
AU  - Watanabe, Teruki
AU  - Kodama, Tetsuro
AU  - Tominaga, Keigo
AU  - Sasagawa, Michizo
AU  - Koyama, Yasuo
AD  - Epidemiology Unit, Research Institute, Tochigi Cancer Center. Pediatrics Unit, Oomuta National Hospital, Omuta, Fukuoka. Department of Surgery. Department of Diagnostic Imaging, Tochigi Cancer Center. Medical Director. Department of Health Checkup and Examination, Tochigi Public Health Service Association. First Department of Surgery, Dokkyo Medical College, Shimotsuga-gun, Tochigi. Tochigi National Hospital, Utsunomiya. Health Promotion Division, Tochigi Prefectural Government, Utsunomiya. Tochigi Public Health Service Association, Utsunomiya. Tochigi Cancer Center, Utsunomiya, Japan
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 715
EP  - 720
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 37
IS  - 9
SN  - 0368-2811, 0368-2811
KW  - Biotechnology and Bioengineering Abstracts
KW  - Mortality
KW  - Age
KW  - Mammography
KW  - Population studies
KW  - Breast cancer
KW  - Ultrasonography
KW  - Clinical trials
KW  - W 30910:Imaging
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-01
N1  - Last updated - 2011-12-13
N1  - SubjectsTermNotLitGenreText - Clinical trials; Mammography; Ultrasonography; Breast cancer; Mortality; Population studies; Age
ER  - 



TY  - JOUR
T1  - Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome
AN  - 20338177; 7616787
AB  - Little is known about genetic regulation of the development of white matter. This knowledge is critical in understanding the pathophysiology of neurodevelopmental syndromes associated with altered cognition as well as in elucidating the genetics of normal human cognition. The hemideletion of approximately 25 genes on chromosome 7q11.23 that causes Williams syndrome (WS) includes genes that regulate cytoskeletal dynamics in neurons, especially LIMK1 and CYLN2, and therefore offers the opportunity to investigate the role of these genes in the formation of white matter tracts. We used diffusion tensor imaging to demonstrate alteration in white matter fiber directionality, deviation in posterior fiber tract course, and reduced lateralization of fiber coherence in WS. These abnormalities are consistent with an alteration of the late stages of neuronal migration, define alterations of white matter structures underlying dissociable behavioral phenotypes in WS, and provide human in vivo information about genetic control of white matter tract formation.
JF  - Proceedings of the National Academy of Sciences, USA
AU  - Marenco, Stefano
AU  - Siuta, Michael A
AU  - Kippenhan, JShane
AU  - Grodofsky, Samuel
AU  - Chang, Wei-li
AU  - Kohn, Philip
AU  - Mervis, Carolyn B
AU  - Morris, Colleen A
AU  - Weinberger, Daniel R
AU  - Meyer-Lindenberg, Andreas
AU  - Pierpaoli, Carlo
AU  - Berman, Karen Faith
AD  - Clinical Brain Disorders Branch (CBDB), Genes Cognition and Psychosis Program (GCAP), Intramural Research Program (IRP), National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD 20892
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 15117
EP  - 15122
PB  - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA
VL  - 104
IS  - 38
SN  - 0027-8424, 0027-8424
KW  - CSA Neurosciences Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW  - Neurodevelopmental disorders
KW  - Magnetic resonance imaging
KW  - LIM kinase
KW  - Substantia alba
KW  - Cognition
KW  - chromosome 7
KW  - Cytoskeleton
KW  - Fibers
KW  - Neurons
KW  - Genetic control
KW  - Cell migration
KW  - Williams syndrome
KW  - W 30910:Imaging
KW  - N3 11023:Neurogenetics
KW  - G 07730:Development & Cell Cycle
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Cytoskeleton; Neurodevelopmental disorders; Fibers; Neurons; LIM kinase; Magnetic resonance imaging; Substantia alba; Genetic control; Cell migration; Williams syndrome; Cognition; chromosome 7
ER  - 



TY  - JOUR
T1  - Exploring the Underlying Hormonal Mechanisms of Prenatal Risk Factors for Breast Cancer: A Review and Commentary
AN  - 20332449; 7610337
AB  - Prenatal factors have been hypothesized to influence subsequent breast cancer development. Directly evaluating the associations of in utero exposures with risk, however, presents several methodologic and theoretical challenges, including the long induction period between exposure and disease and the lack of certainty regarding the critical timing of exposure. Indirect evaluation of these associations has been achieved by use of proxies such as gestational and neonatal characteristics. Evidence suggests that preeclampsia is associated with a reduced breast cancer risk, whereas high birth weight and dizygotic twinning seem associated with an increased risk. Asians born in Asia have substantially lower breast cancer risks than women born in the West. Although data thus far are few, what exists is not consistent with a unifying hypothesis for a particular biological exposure (such as estrogens or androgens) during pregnancy as mediating the observed associations between pregnancy factors and breast cancer risk. This suggests that additional studies of prenatal factors should seek to broaden the range of hormones, growth, and other endocrine factors that are evaluated in utero. Once candidate biomarkers are identified, assessing them with respect to breast cancer and with intermediate end points in carcinogenesis should be a priority. In addition, investigations should explore the possibility that in utero exposures may not act directly on the breast, but may alter other physiologic pathways such as hormone metabolism that have their effect on risk later in life. (Cancer Epidemiol Biomarkers Prev 2007; 16(9):1700-12)
JF  - Cancer Epidemiology, Biomarkers & Prevention
AU  - Troisi, Rebecca
AU  - Potischman, Nancy
AU  - Hoover, Robert N
AD  - Divisions of Cancer Epidemiology and Genetics and Cancer Control and Population Science, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 1700
EP  - 1712
PB  - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/]
VL  - 16
IS  - 9
SN  - 1055-9965, 1055-9965
KW  - Risk Abstracts
KW  - Bioindicators
KW  - Prenatal experience
KW  - Hormones
KW  - Pregnancy
KW  - Reviews
KW  - Carcinogenesis
KW  - prevention
KW  - Breast cancer
KW  - birth weight
KW  - Asia
KW  - Metabolism
KW  - estrogens
KW  - R2 23060:Medical and environmental health
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Exploring+the+Underlying+Hormonal+Mechanisms+of+Prenatal+Risk+Factors+for+Breast+Cancer%3A+A+Review+and+Commentary&rft.au=Troisi%2C+Rebecca%3BPotischman%2C+Nancy%3BHoover%2C+Robert+N&rft.aulast=Troisi&rft.aufirst=Rebecca&rft.date=2007-09-01&rft.volume=16&rft.issue=9&rft.spage=1700&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Bioindicators; Prenatal experience; Reviews; Carcinogenesis; prevention; birth weight; Breast cancer; Hormones; Metabolism; estrogens; Pregnancy; Asia
ER  - 



TY  - JOUR
T1  - Development of a Multiplex Real-Time PCR Assay with an Internal Amplification Control for the Detection of Total and Pathogenic Vibrio parahaemolyticus Bacteria in Oysters
AN  - 20001590; 7608105
AB  - Vibrio parahaemolyticus is an estuarine bacterium that is the leading cause of shellfish-associated cases of bacterial gastroenteritis in the United States. Our laboratory developed a real-time multiplex PCR assay for the simultaneous detection of the thermolabile hemolysin (tlh), thermostable direct hemolysin (tdh), and thermostable-related hemolysin (trh) genes of V. parahaemolyticus. The tlh gene is a species-specific marker, while the tdh and trh genes are pathogenicity markers. An internal amplification control (IAC) was incorporated to ensure PCR integrity and eliminate false-negative reporting. The assay was tested for specificity against >150 strains representing eight bacterial species. Only V. parahaemolyticus strains possessing the appropriate target genes generated a fluorescent signal, except for a late tdh signal generated by three strains of V. hollisae. The multiplex assay detected 10 super(4) CFU/reaction of total V. parahaemolyticus bacteria. The real-time PCR assay was utilized with a most-probable-number format, and its results were compared to standard V. parahaemolyticus isolation methodology during an environmental survey of Alaskan oysters. The IAC was occasionally inhibited by the oyster matrix, and this usually corresponded to negative results for V. parahaemolyticus targets. V. parahaemolyticus tlh, tdh, and trh were detected in 44, 44, and 52% of the oyster samples, respectively. V. parahaemolyticus was isolated from 33% of the samples, and tdh super(+) and trh super(+) strains were isolated from 19 and 26%, respectively. These results demonstrate the utility of the real-time PCR assay in environmental surveys and its possible application to outbreak investigations for the detection of total and pathogenic V. parahaemolyticus.
JF  - Applied and Environmental Microbiology
AU  - Nordstrom, Jessica L
AU  - Vickery, Michael CL
AU  - Blackstone, George M
AU  - Murray, Shelley L
AU  - DePaola, Angelo
AD  - Gulf Coast Seafood Laboratory, Division of Seafood Science and Technology, U.S. Food and Drug Administration, Dauphin Island, Alabama 36528. Alaska Department of Environmental Conservation, Anchorage, Alaska 99501
Y1  - 2007/09//
PY  - 2007
DA  - September 2007
SP  - 5840
EP  - 5847
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA
VL  - 73
IS  - 18
SN  - 0099-2240, 0099-2240
KW  - Microbiology Abstracts B: Bacteriology; ASFA Marine Biotechnology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources
KW  - Pathogenic bacteria
KW  - Nucleotide sequence
KW  - Estuaries
KW  - Brackish
KW  - tlh gene
KW  - Pathogenicity
KW  - Vibrio parahaemolyticus
KW  - Colony-forming cells
KW  - DNA
KW  - Polymerase chain reaction
KW  - Marine molluscs
KW  - Shellfish
KW  - Disease detection
KW  - Gastroenteritis
KW  - Hemolysins
KW  - Environmental surveys
KW  - Q1 08484:Species interactions: parasites and diseases
KW  - Q4 27700:Molecular Techniques
KW  - A 01300:Methods
KW  - J 02450:Ecology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2016-05-27
N1  - SubjectsTermNotLitGenreText - Pathogenic bacteria; Nucleotide sequence; Estuaries; DNA; Marine molluscs; Polymerase chain reaction; Shellfish; Disease detection; tlh gene; Pathogenicity; Colony-forming cells; Gastroenteritis; Hemolysins; Environmental surveys; Vibrio parahaemolyticus; Brackish
ER  - 



TY  - JOUR
T1  - Application of allometric principles for the prediction of pharmacokinetics in human and veterinary drug development
AN  - 19909906; 8768007
AB  - The concept of correlating pharmacokinetic parameters with body weight (termed as pharmacokinetic interspecies scaling) from different animal species has become a useful tool in drug development. Interspecies scaling is based on the power function, where the body weight of the species is plotted against the pharmacokinetic parameter of interest. Clearance, volume of distribution, and elimination half-life are the three most frequently extrapolated pharmacokinetic parameters. The predicted pharmacokinetic parameter clearance can be used for estimating a first-in-human dose. Over the years, many approaches have been suggested to improve the prediction of aforementioned pharmacokinetic parameters in humans from animal data. A literature review indicates that there are different degrees of success with different methods for different drugs. Interspecies scaling is also a very useful tool in veterinary medicine. The knowledge of pharmacokinetics in veterinary medicine is important for dosage selection, particularly in the treatment of large animals such as horses, camels, elephants, or other large zoo animals. Despite the potential for extrapolation error, the reality is that interspecies scaling is needed across many veterinary practice situations, and therefore will be used. For this reason, it is important to consider mechanisms for reducing the risk of extrapolation errors that can seriously affect animal safety and therapeutic response. Overall, although interspecies scaling requires continuous refinement and better understanding, the rationale approach of interspecies scaling has a lot of potential during the drug development process.
JF  - Advanced Drug Delivery Reviews
AU  - Mahmood, Iftekhar
AD  - Office of Blood Review & Research (OBRR), Center for Biologic Evaluation and Research, Food & Drug Administration, 1451 Rockville Pike, MD, USA, Iftekhar.mahmood@fda.hhs.gov
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 1177
EP  - 1192
PB  - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl]
VL  - 59
IS  - 11
SN  - 0169-409X, 0169-409X
KW  - Biotechnology and Bioengineering Abstracts
KW  - Drug delivery
KW  - Veterinary medicine
KW  - Data processing
KW  - Body weight
KW  - Elephantidae
KW  - Drug development
KW  - Scaling
KW  - Pharmacokinetics
KW  - W 30915:Pharmaceuticals & Vaccines
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Application+of+allometric+principles+for+the+prediction+of+pharmacokinetics+in+human+and+veterinary+drug+development&rft.au=Mahmood%2C+Iftekhar&rft.aulast=Mahmood&rft.aufirst=Iftekhar&rft.date=2007-09-01&rft.volume=59&rft.issue=11&rft.spage=1177&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2007.05.015
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - Elephantidae; Pharmacokinetics; Scaling; Drug development; Veterinary medicine; Body weight; Data processing; Drug delivery
DO  - http://dx.doi.org/10.1016/j.addr.2007.05.015
ER  - 



TY  - JOUR
T1  - Toward a Checklist for Exchange and Interpretation of Data from a Toxicology Study
AN  - 19747088; 7561131
AB  - Data from toxicology and toxicogenomics studies are valuable, and can be combined for meta-analysis using public data repositories such as Chemical Effects in Biological Systems Knowledgebase, ArrayExpress, and Gene Expression Omnibus. In order to fully utilize the data for secondary analysis, it is necessary to have a description of the study and good annotation of the accompanying data. This study annotation permits sophisticated cross-study comparison and analysis, and allows data from comparable subjects to be identified and fully understood. The Minimal Information About a Microarray Experiment Standard was proposed to permit deposition and sharing of microarray data. We propose the first step toward an analogous standard for a toxicogenomics/toxicology study, by describing a checklist of information that best practices would suggest be included with the study data. When the information in this checklist is deposited together with the study data, the checklist information helps the public explore the study data in context of time, or identify data from similarly treated subjects, and also explore/identify potential sources of experimental variability. The proposed checklist summarizes useful information to include when sharing study data for publication, deposition into a database, or electronic exchange with collaborators. It is not a description of how to carry out an experiment, but a definition of how to describe an experiment. It is anticipated that once a toxicology checklist is accepted and put into use, then toxicology databases can be configured to require and output these fields, making it straightforward to annotate data for interpretation by others.
JF  - Toxicological Sciences
AU  - Fostel, Jennifer M
AU  - Burgoon, Lyle
AU  - Zwickl, Craig
AU  - Lord, Peter
AU  - Corton, JChristopher
AU  - Bushel, Pierre R
AU  - Cunningham, Michael
AU  - Fan, Liju
AU  - Edwards, Stephen W
AU  - Hester, Susan
AU  - Stevens, James
AU  - Tong, Weida
AU  - Waters, Michael
AU  - Yang, ChiHae
AU  - Tennant, Raymond
AD  - NIEHS, LMIT ITSS Contract, Research Triangle Park, North Carolina 27709-2233. Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824. Lilly Research Laboratory, Greenfield, Indiana 46140. Johnson and Johnson PRD, Raritan, New Jersey 08869. National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711. NIEHS, Research Triangle Park, North Carolina 27709-2233. National Toxicology Program, Research Triangle Park, North Carolina 27709. Ontology Workshop, LLC, Columbia, Maryland 21045-9998. National Center for Toxicological Research, Jefferson, Arkansas 72079. Integrated Life Sciences, Research Triangle Park, North Carolina 27709. Leadscope, Columbus, Ohio 43212
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 26
EP  - 34
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 99
IS  - 1
SN  - 1096-6080, 1096-6080
KW  - Toxicology Abstracts
KW  - Gene expression
KW  - Databases
KW  - Data processing
KW  - Reviews
KW  - Check lists
KW  - X 24300:Methods
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19747088?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Toward+a+Checklist+for+Exchange+and+Interpretation+of+Data+from+a+Toxicology+Study&rft.au=Fostel%2C+Jennifer+M%3BBurgoon%2C+Lyle%3BZwickl%2C+Craig%3BLord%2C+Peter%3BCorton%2C+JChristopher%3BBushel%2C+Pierre+R%3BCunningham%2C+Michael%3BFan%2C+Liju%3BEdwards%2C+Stephen+W%3BHester%2C+Susan%3BStevens%2C+James%3BTong%2C+Weida%3BWaters%2C+Michael%3BYang%2C+ChiHae%3BTennant%2C+Raymond&rft.aulast=Fostel&rft.aufirst=Jennifer&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Gene expression; Databases; Data processing; Reviews; Check lists
ER  - 



TY  - JOUR
T1  - Widening Socioeconomic Disparities in US Childhood Mortality, 1969-2000
AN  - 19741720; 7554421
AB  - OBJECTIVES: We examined the extent to which area socioeconomic inequalities in overall and cause-specific mortality among US children aged 1-14 years changed between 1969 and 2000. METHODS: We linked a census-based deprivation index to US county mortality data from 1969 to 2000. We used Poisson and log-linear regression and inequality indices to analyze temporal disparities. RESULTS: Despite marked declines in child mortality, socioeconomic gradients (relative mortality risks) in overall child mortality increased substantially during the study period. During 1969-1971, children in the most deprived socioeconomic quintile had 52%, 13%, 69%, and 76% higher risks of all-cause, birth defect, unintentional injury, and homicide mortality, respectively, than did children in the least deprived socioeconomic quintile. The corresponding relative risks increased to 86%, 44%, 177%, 159%, respectively from 1998-2000. CONCLUSIONS: Dramatic reductions in mortality among children in all socioeconomic quintiles represent a major public health success. However, children in higher socioeconomic quintiles experienced much larger declines in overall, injury, and natural-cause mortality than did those in more deprived socioeconomic quintiles, which contributed to the widening socioeconomic gap in mortality. Widening disparities in child mortality may reflect increasing polarization among deprivation quintiles in material and social conditions.
JF  - American Journal of Public Health
AU  - Singh, Gopal K
AU  - Kogan, Michael D
AD  - Gopal K. Singh and Michael D. Kogan are with the Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, Md
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 1658
EP  - 1665
PB  - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA
VL  - 97
IS  - 9
SN  - 0090-0036, 0090-0036
KW  - Sustainability Science Abstracts; Health & Safety Science Abstracts; Risk Abstracts
KW  - Mortality
KW  - homicide
KW  - Injuries
KW  - Socioeconomics
KW  - Congenital defects
KW  - social conditions
KW  - Children
KW  - Polarization
KW  - Public health
KW  - M3 1010:Issues in Sustainable Development
KW  - R2 23060:Medical and environmental health
KW  - H 12000:Epidemiology and Public Health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19741720?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Widening+Socioeconomic+Disparities+in+US+Childhood+Mortality%2C+1969-2000&rft.au=Singh%2C+Gopal+K%3BKogan%2C+Michael+D&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2007-09-01&rft.volume=97&rft.issue=9&rft.spage=1658&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Mortality; homicide; Injuries; Congenital defects; Socioeconomics; social conditions; Polarization; Children; Public health
ER  - 



TY  - JOUR
T1  - A Nested Case-Control Study of Lung Cancer Risk and Ionizing Radiation Exposure at the Portsmouth Naval Shipyard
AN  - 19714069; 8196269
AB  - Results have been inconsistent between studies of lung cancer risk and ionizing radiation exposures among workers at the Portsmouth Naval Shipyard (PNS). The purpose of this nested case-control study was to evaluate the relationship between lung cancer risk and external ionizing radiation exposure while adjusting for potential confounders that included gender, radiation monitoring status, smoking habit surrogates (socioeconomic status and birth cohort), welding fumes and asbestos. By incidence density sampling, we age-matched 3,291 controls selected from a cohort of 37,853 civilian workers employed at PNS between 1952 and 1992 with 1,097 lung cancer deaths from among the same cohort. Analyses using conditional logistic regression were conducted in various model forms: log-linear (main), linear excess relative risk (ERR), and categorical. Lung cancer risk was positively associated with occupational dose (OR = 1.02 at 10 mSv; 95% CI 0.99- 1.04) but flattened after the inclusion of work-related medical X-ray doses (OR = 1.00; 95% CI 0.98-1.03) in multivariate analyses. Similar risk estimates were observed in the linear ERR model at 10 mSv of cumulative exposure with a 15-year lag.
JF  - Radiation Research
AU  - Yiin, J H
AU  - Silver
AU  - Daniels, R D
AU  - Zaebst, D D
AU  - Seel, E A
AU  - Kubale, T L
AD  - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 341
EP  - 348
PB  - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com]
VL  - 168
IS  - 3
SN  - 0033-7587, 0033-7587
KW  - Health & Safety Science Abstracts; Toxicology Abstracts
KW  - Risk assessment
KW  - Socioeconomics
KW  - Models
KW  - Smoking
KW  - Workers
KW  - Multivariate analysis
KW  - Regression analysis
KW  - Welding
KW  - Sampling
KW  - Occupational exposure
KW  - Lung cancer
KW  - Mortality
KW  - Asbestos
KW  - Fumes
KW  - Cancer
KW  - Socio-economic aspects
KW  - Ionizing radiation
KW  - Gender
KW  - USA, New Hampshire, Portsmouth
KW  - X 24390:Radioactive Materials
KW  - H 1000:Occupational Safety and Health
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L2  - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=168&issue=3&page=341
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-06-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Risk assessment; Asbestos; Fumes; Models; Workers; Socio-economic aspects; Smoking; Multivariate analysis; Ionizing radiation; Regression analysis; Welding; Sampling; Occupational exposure; Lung cancer; Mortality; Gender; Socioeconomics; Cancer; USA, New Hampshire, Portsmouth
DO  - http://dx.doi.org/10.1667/RR0843.1
ER  - 



TY  - JOUR
T1  - Update of US FDA's Total Diet Study food list and diets
AN  - 19568960; 8831897
AB  - The US Food and Drug Administration's (FDA) Total Diet Study (TDS) has been conducted continuously since the early 1960s to measures levels of various pesticide residues, contaminants, and nutrients in foods and to estimate the dietary exposures to these compounds. Both the TDS food list and the consumption amounts used for estimating exposures are based on results of nationwide food consumption surveys, and they are updated periodically to reflect changes in food consumption patterns. The most recent update was completed in 2003 using the same methodology employed in the previous update (1990). The updated food list includes approximately the same number of foods (285) as the previous list (290). Although most (75%) foods are the same in both versions, the new list reflects trends in consumption of foods containing less fat. The updated diets reflect an increase in total food consumption, with most notable increases in consumption of grains and beverages. A case study comparing cadmium exposures calculated from both the 1990 and 2003 versions of the TDS demonstrated the potential impact of changes in both the food list and consumption amounts on TDS exposure estimates.
JF  - Journal of Exposure Science and Environmental Epidemiology
AU  - Egan, S K
AU  - Bolger, P M
AU  - Carrington, C D
AD  - HFS-301, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA, Katie.Egan@fda.hhs.gov
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 573
EP  - 582
VL  - 17
IS  - 6
SN  - 1559-0631, 1559-0631
KW  - Pollution Abstracts
KW  - Diets
KW  - Pesticide residues
KW  - case studies
KW  - nutrients
KW  - USA
KW  - FDA
KW  - cadmium
KW  - Drugs
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19568960?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Update+of+US+FDA%27s+Total+Diet+Study+food+list+and+diets&rft.au=Egan%2C+S+K%3BBolger%2C+P+M%3BCarrington%2C+C+D&rft.aulast=Egan&rft.aufirst=S&rft.date=2007-09-01&rft.volume=17&rft.issue=6&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fsj.jes.7500554
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-12-01
N1  - Last updated - 2011-12-14
N1  - SubjectsTermNotLitGenreText - nutrients; case studies; Diets; Pesticide residues; cadmium; FDA; Drugs; USA
DO  - http://dx.doi.org/10.1038/sj.jes.7500554
ER  - 



TY  - JOUR
T1  - Water separator shows potential for reducing respirable dust generated on small-diameter rotary blasthole drills
AN  - 17695423; 7605460
AB  - Drilling with water has the potential to significantly reduce the respirable dust concentrations generated from small-diameter rotary drills when drilling blastholes on surface mining operations. However, water adversely affects tri-cone drill bits commonly used in surface drilling operations, causing excessive wear and premature replacement. Consequently, dry drilling with a dust collector system has the most widespread use in the industry. Tests have been conducted by the National Institute of Occupational Safety and Health (NIOSH), Pittsburgh Research Laboratory (PRL) on a newly designed device for smaller diameter drills that separates the water from the bailing air before it reaches the bit and thus provides the cost benefit of dry drilling while providing the benefit of wet drilling for dust suppression. The water that is delivered to the hole with the bailing air is separated from the air by a proprietary mechanical device that is encased in a drill sub (short section of drill rod/pipe) located immediately behind the cutting bit. A cascade cyclone and a real-time dust monitor were used to sample dust emissions from the holes. Dust concentrations and silica content were measured when drilling dry versus drilling wet. The tests show that drilling with this water separating sub can reduce both measured dust emissions from the boreholes and visible dust around the drill rig.
JF  - International Journal of Mining, Reclamation and Environment
AU  - Listak, J M
AU  - Reed, W R
AD  - Pittsburgh Research Laboratory, Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, PO Box 18070, Pittsburgh, PA 15236, USA, jlistak@cdc.gov
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 160
EP  - 172
VL  - 21
IS  - 3
SN  - 1748-0930, 1748-0930
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - Inhalation
KW  - Pipes
KW  - boreholes
KW  - silica
KW  - reclamation
KW  - Emissions
KW  - Mining
KW  - wear
KW  - Dust collectors
KW  - Occupational exposure
KW  - H 1000:Occupational Safety and Health
KW  - P 6000:TOXICOLOGY AND HEALTH
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17695423?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Mining%2C+Reclamation+and+Environment&rft.atitle=Water+separator+shows+potential+for+reducing+respirable+dust+generated+on+small-diameter+rotary+blasthole+drills&rft.au=Listak%2C+J+M%3BReed%2C+W+R&rft.aulast=Listak&rft.aufirst=J&rft.date=2007-09-01&rft.volume=21&rft.issue=3&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Mining%2C+Reclamation+and+Environment&rft.issn=17480930&rft_id=info:doi/10.1080%2F17480930601176846
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Inhalation; Pipes; boreholes; silica; reclamation; Emissions; Mining; Dust collectors; wear; Occupational exposure
DO  - http://dx.doi.org/10.1080/17480930601176846
ER  - 



TY  - JOUR
T1  - Unintended Consequences of Information Technologies in Health Care-An Interactive Sociotechnical Analysis
AN  - 17274449; 7613683
AB  - Many unintended and undesired consequences of Healthcare Information Technologies (HIT) flow from interactions between the HIT and the healthcare organization's sociotechnical system-its workflows, culture, social interactions, and technologies. This paper develops and illustrates a conceptual model of these processes that we call Interactive Sociotechnical Analysis (ISTA). ISTA captures common types of interaction with special emphasis on recursive processes, i.e., feedback loops that alter the newly introduced HIT and promote second-level changes in the social system. ISTA draws on prior studies of unintended consequences, along with research in sociotechnical systems, ergonomics, social informatics, technology-in-practice, and social construction of technology. We present five types of sociotechnical interaction and illustrate each with cases from published research. The ISTA model should further research on emergent and recursive processes in HIT implementation and their unintended consequences. Familiarity with the model can also foster practitioners' awareness of unanticipated consequences that only become evident during HIT implementation.
JF  - Journal of the American Medical Informatics Association
AU  - Harrison, Michael I
AU  - Koppel, Ross
AU  - Bar-Lev, Shirly
AD  - Agency for Healthcare Research and Quality, Rockville, MD. University of Pennsylvania, Philadelphia, PA. Ruppin Academic Center, Emek Hefer, Israel
Y1  - 2007/09//
PY  - 2007
DA  - Sep 2007
SP  - 542
EP  - 549
PB  - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org]
VL  - 14
IS  - 5
SN  - 1067-5027, 1067-5027
KW  - Biotechnology and Bioengineering Abstracts
KW  - Feedback
KW  - Models
KW  - Social interactions
KW  - W 30960:Bioinformatics & Computer Applications
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Feedback; Social interactions; Models
ER  - 



TY  - CPAPER
T1  - Fabry Disease: What Pediatric Nephrologists should Know?
T2  - 14th Congress of the International Pediatric Nephrology Association (IPNA 2007)
AN  - 39422996; 4646330
JF  - 14th Congress of the International Pediatric Nephrology Association (IPNA 2007)
AU  - Cho, M
Y1  - 2007/08/31/
PY  - 2007
DA  - 2007 Aug 31
KW  - Pediatrics
KW  - Fabry's disease
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39422996?accountid=14244
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L2  - http://www.ipna2007.com/final_programme/index.html
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Repetitive Exposures of Stretch-Shortening Cycles Affects Muscle Performance Differentially with Age
T2  - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007)
AN  - 39670129; 4698997
JF  - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007)
AU  - Cutlip, R G
AU  - Baker, B A
AU  - Mercer, R R
AU  - Kashon, M L
AU  - Alway, S E
Y1  - 2007/08/27/
PY  - 2007
DA  - 2007 Aug 27
KW  - Muscles
KW  - Age
KW  - U 2000:Biological Sciences
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Prospective Study of Risk Factors for Low Back Disorders due to Manual Lifting: Exposure Assessment Methods
T2  - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007)
AN  - 39537133; 4699303
JF  - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007)
AU  - Waters, T
AU  - Piacitelli, L
AU  - Lu, M.
AU  - Werren, D
Y1  - 2007/08/27/
PY  - 2007
DA  - 2007 Aug 27
KW  - Lifting
KW  - Risk factors
KW  - Manuals
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537133?accountid=14244
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L2  - http://www.premus2007.org/conference-program.htm
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Accuracy and Reliability of Human Postural Simulation for Assessing Physical Risk Factors Associated with Low Back Disorders
T2  - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007)
AN  - 39530098; 4699062
JF  - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007)
AU  - Lu, M.
AU  - Waters, T
AU  - Piacitelli, L
AU  - Werren, D
Y1  - 2007/08/27/
PY  - 2007
DA  - 2007 Aug 27
KW  - Simulation
KW  - Posture
KW  - Risk factors
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39530098?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.atitle=Accuracy+and+Reliability+of+Human+Postural+Simulation+for+Assessing+Physical+Risk+Factors+Associated+with+Low+Back+Disorders&rft.au=Lu%2C+M.%3BWaters%2C+T%3BPiacitelli%2C+L%3BWerren%2C+D&rft.aulast=Lu&rft.aufirst=M.&rft.date=2007-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.issn=&rft_id=info:doi/
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - The NIOSH Musculoskeletal Disorder Consortium
T2  - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007)
AN  - 39529675; 4698978
JF  - Sixth International Scientific Conference on Prevention of Work-Related Musculoskeletal Disorders (PREMUS 2007)
AU  - Burt, S
AU  - Waters, T
AU  - Piacitelli, L
AU  - Fine, L
AU  - Silverstein, B
AU  - Marras, W
AU  - Garg, A
AU  - Hegmann, K
AU  - Rempel, D
AU  - Gerr, F
AU  - Cherniak, M
AU  - Evanoff, B
Y1  - 2007/08/27/
PY  - 2007
DA  - 2007 Aug 27
KW  - Musculoskeletal system
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39529675?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.atitle=The+NIOSH+Musculoskeletal+Disorder+Consortium&rft.au=Burt%2C+S%3BWaters%2C+T%3BPiacitelli%2C+L%3BFine%2C+L%3BSilverstein%2C+B%3BMarras%2C+W%3BGarg%2C+A%3BHegmann%2C+K%3BRempel%2C+D%3BGerr%2C+F%3BCherniak%2C+M%3BEvanoff%2C+B&rft.aulast=Burt&rft.aufirst=S&rft.date=2007-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+International+Scientific+Conference+on+Prevention+of+Work-Related+Musculoskeletal+Disorders+%28PREMUS+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.premus2007.org/conference-program.htm
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Impact of Systems Toxicology on the 3Rs
T2  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AN  - 39725296; 4721562
JF  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AU  - Fuscoe, James C
Y1  - 2007/08/21/
PY  - 2007
DA  - 2007 Aug 21
KW  - Toxicology
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39725296?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Impact+of+Systems+Toxicology+on+the+3Rs&rft.au=Fuscoe%2C+James+C&rft.aulast=Fuscoe&rft.aufirst=James&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/
L2  - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Toxicity Screening of Herbal Extracts Using Transcriptional Activation System
T2  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AN  - 39605734; 4721744
JF  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AU  - Lim, Chaehyung
Y1  - 2007/08/21/
PY  - 2007
DA  - 2007 Aug 21
KW  - Toxicity
KW  - Transcription activation
KW  - Screening
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39605734?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Toxicity+Screening+of+Herbal+Extracts+Using+Transcriptional+Activation+System&rft.au=Lim%2C+Chaehyung&rft.aulast=Lim&rft.aufirst=Chaehyung&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/
L2  - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Current Status of the Developmental and Reproductive Toxicity Tests in NITR, Korea
T2  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AN  - 39591872; 4721479
JF  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AU  - Park, Kui Lea
Y1  - 2007/08/21/
PY  - 2007
DA  - 2007 Aug 21
KW  - Korea, Rep.
KW  - Toxicity testing
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39591872?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Current+Status+of+the+Developmental+and+Reproductive+Toxicity+Tests+in+NITR%2C+Korea&rft.au=Park%2C+Kui+Lea&rft.aulast=Park&rft.aufirst=Kui&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/
L2  - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Databases and QSARs for Chemical Toxicities in Animals and Adverse Effects in Humans
T2  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AN  - 39580994; 4721844
JF  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AU  - Benz, Daniel R
Y1  - 2007/08/21/
PY  - 2007
DA  - 2007 Aug 21
KW  - Toxicity
KW  - Side effects
KW  - Databases
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580994?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Databases+and+QSARs+for+Chemical+Toxicities+in+Animals+and+Adverse+Effects+in+Humans&rft.au=Benz%2C+Daniel+R&rft.aulast=Benz&rft.aufirst=Daniel&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/
L2  - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Toxicological and Clinical Computational Analyis and the US FDA/CDER
T2  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AN  - 39578033; 4721500
JF  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AU  - Benz, Daniel R
Y1  - 2007/08/21/
PY  - 2007
DA  - 2007 Aug 21
KW  - FDA
KW  - Computer applications
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39578033?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Toxicological+and+Clinical+Computational+Analyis+and+the+US+FDA%2FCDER&rft.au=Benz%2C+Daniel+R&rft.aulast=Benz&rft.aufirst=Daniel&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/
L2  - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - ICCVAM Revised Recommended Substances for the Validation of In Vitro Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Test Methods
T2  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AN  - 39576362; 4721859
JF  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AU  - Hattan, David
Y1  - 2007/08/21/
PY  - 2007
DA  - 2007 Aug 21
KW  - Estrogen receptors
KW  - Transcription activation
KW  - Androgen receptors
KW  - Sex hormones
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39576362?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=The+identification+of+antibacterial+compounds+for+the+development+of+enhanced+media+for+the+detection+of+foodborne+fungi&rft.au=Tournas%2C+V+H%3BKohn%2C+J+S%3BKatsoudas%2C+E+J&rft.aulast=Tournas&rft.aufirst=V&rft.date=2007-08-01&rft.volume=118&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2007.04.013
L2  - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - NICEATM and ICCVAM Evaluation of Five In Vitro Test Methods for Assessing Potential Pyrogenicity of Pharmaceuticals and other Products
T2  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AN  - 39532303; 4721881
JF  - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6)
AU  - McFarland, Richard
Y1  - 2007/08/21/
PY  - 2007
DA  - 2007 Aug 21
KW  - Pharmaceuticals
KW  - Pyrogenicity
KW  - U 2000:Biological Sciences
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N1  - Date revised - 2007-12-18
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TY  - CPAPER
T1  - Analysis of Usnic Acid from Usnea sp. Dispersed in Rodent Diet by HPLC
T2  - 234th National Meeting and Exposition of the American Chemical Society
AN  - 39492669; 4629620
JF  - 234th National Meeting and Exposition of the American Chemical Society
AU  - Evans, Ronald L
AU  - Siitonen, Paul H
Y1  - 2007/08/19/
PY  - 2007
DA  - 2007 Aug 19
KW  - Diets
KW  - Rodents
KW  - Usnic acid
KW  - High-performance liquid chromatography
KW  - Usnea
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Role of Dietary Components on Acrylamide Induced Neurotransmitter Turnover Alterations in Pc 12 Cells
T2  - 234th National Meeting and Exposition of the American Chemical Society
AN  - 39459224; 4635277
JF  - 234th National Meeting and Exposition of the American Chemical Society
AU  - Tareke, Eden
AU  - Ali, Syed
AU  - Lyn-Cook, Beverly
AU  - Duhart, Helen M
Y1  - 2007/08/19/
PY  - 2007
DA  - 2007 Aug 19
KW  - Diets
KW  - Neurotransmitters
KW  - Acrylamide
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Irradiation of Retinol in Ethanol with UVA Light: Formation of Photodecomposition Products, Reactive Oxygen Species, and Lipid Peroxides
T2  - 234th National Meeting and Exposition of the American Chemical Society
AN  - 39455857; 4635243
JF  - 234th National Meeting and Exposition of the American Chemical Society
AU  - Xia, Qingsu
AU  - Yin, Jun Jie
AU  - Cherng, Shu-Hui
AU  - Freeman, James P
AU  - Yu, Hongtao
AU  - Boudreau, Mary D
AU  - Wamer, Wayne G
AU  - Fu, Peter P
Y1  - 2007/08/19/
PY  - 2007
DA  - 2007 Aug 19
KW  - Ethanol
KW  - Reactive oxygen species
KW  - Lipid peroxidation
KW  - Irradiation
KW  - U.V. radiation
KW  - Radiation
KW  - Peroxide
KW  - Vitamin A
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Characterization of Perfluorochemicals in Food Packaging by Direct Analysis in Real Time-mass Spectrometry (dart-MS)
T2  - 234th National Meeting and Exposition of the American Chemical Society
AN  - 39432614; 4629511
JF  - 234th National Meeting and Exposition of the American Chemical Society
AU  - Noonan, Gregory O
AU  - Begley, Timothy H
AU  - Diachenko, Gregory W
Y1  - 2007/08/19/
PY  - 2007
DA  - 2007 Aug 19
KW  - Spectrometry
KW  - Packaging
KW  - Perfluorochemicals
KW  - Food
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Evaluation of Modern Extraction Methods for the Analysis of Tetramethylene Disulfotetramine in Foods
T2  - 234th National Meeting and Exposition of the American Chemical Society
AN  - 39432560; 4629505
JF  - 234th National Meeting and Exposition of the American Chemical Society
AU  - Dejager, Lowri
AU  - Perfetti, Gracia A
AU  - Diachenko, Gregory W
Y1  - 2007/08/19/
PY  - 2007
DA  - 2007 Aug 19
KW  - Food
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Analysis of Nitrofuran Residues in Shrimp, Channel Catfish, and Milk using Liquid Chromatography-Tandem Mass Spectrometry
T2  - 234th National Meeting and Exposition of the American Chemical Society
AN  - 39429379; 4636250
JF  - 234th National Meeting and Exposition of the American Chemical Society
AU  - Chu, Pak-Sin
AU  - Lopez, Mayda I
AU  - Abraham, Ann
AU  - El Said, Kathleen R
AU  - Plakas, Steven M
Y1  - 2007/08/19/
PY  - 2007
DA  - 2007 Aug 19
KW  - Mass spectroscopy
KW  - Residues
KW  - Milk
KW  - Nitrofurans
KW  - Freshwater fish
KW  - Ictalurus punctatus
KW  - U 2000:Biological Sciences
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N1  - Date revised - 2007-12-18
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TY  - CPAPER
T1  - Niosh: Nanotechnologies Safety and Health Initiatives
T2  - 234th National Meeting and Exposition of the American Chemical Society
AN  - 39412712; 4632658
JF  - 234th National Meeting and Exposition of the American Chemical Society
AU  - Hoover, Mark
Y1  - 2007/08/19/
PY  - 2007
DA  - 2007 Aug 19
KW  - Nanotechnology
KW  - Health and safety
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - PBPK/PD Modeling of Acrylamide: Integration of Kinetic and Biomarker Data for Use in Risk Assessment
T2  - 234th National Meeting and Exposition of the American Chemical Society
AN  - 39375623; 4629694
JF  - 234th National Meeting and Exposition of the American Chemical Society
AU  - Doerge, Daniel R
Y1  - 2007/08/19/
PY  - 2007
DA  - 2007 Aug 19
KW  - Bioindicators
KW  - Risk assessment
KW  - Kinetics
KW  - Integration
KW  - Acrylamide
KW  - Biomarkers
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Some Applications of GC-MS/MS and LC-MS/MS to Analyze Pesticides and Chemical Contaminants in Foods
T2  - 234th National Meeting and Exposition of the American Chemical Society
AN  - 39370574; 4629528
JF  - 234th National Meeting and Exposition of the American Chemical Society
AU  - Wong, Jon W
AU  - Krynitsky, Alexander J
Y1  - 2007/08/19/
PY  - 2007
DA  - 2007 Aug 19
KW  - Pesticides
KW  - Chemical pollution
KW  - Contaminants
KW  - Food contamination
KW  - U 2000:Biological Sciences
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TY  - CPAPER
T1  - Microstructure Characterization of Drug-polymer Composite Coatings
T2  - 234th National Meeting and Exposition of the American Chemical Society
AN  - 39363078; 4631314
JF  - 234th National Meeting and Exposition of the American Chemical Society
AU  - McDermott, Martin K
AU  - Patwardhan, Dinesh V
AU  - Casas, Rachel
AU  - Dair, Benita J
AU  - Kim, Chang-Soo
AU  - Pollack, Steven K
AU  - Saylor, Dave M
AU  - Soffer, Jeffrey M
AU  - Toy, Jeff
AU  - Wang, Christine X
Y1  - 2007/08/19/
PY  - 2007
DA  - 2007 Aug 19
KW  - Coating materials
KW  - Composite materials
KW  - U 2000:Biological Sciences
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TY  - JOUR
T1  - The identification of antibacterial compounds for the development of enhanced media for the detection of foodborne fungi.
AN  - 68131044; 17574697
AB  - In an effort to identify a more suitable antibiotic for utilization in mycological media, 12 food borne fungal species from various genera including Alternaria alternata, Aspergillus flavus, A. niger, Eurotium chevalieri, Fusarium moniliforme, Penicillium sp., Rhizopus stolonifer, Saccharomyces cerevisiae, Candida tropicalis, Geotrichum candidum, Rhodotorula glutinis and Kluyveromyces thermotolerans along with 21 chloramphenicol-resistant bacterial isolates from fresh produce and ATCC cultures of Pseudomonas aeruginosa, P. fluorescens, E. coli, Pectobacterium carotovorum, Bacillus cereus and Staphylococcus spp. were tested for their abilities to grow on dichloran rose bengal agar containing various levels of gentamicin, chlortetracycline or chloramphenicol. Results indicated that all fungal isolates except for Rh. glutinis and R. stolonifer grew well on all media tested. Rh. glutinis did not grow on media containing gentamicin whereas R. stolonifer produced very restricted or no growth on these media. All bacterial isolates from fresh produce, P. aeruginosa (ATCC 27853) and P. fluorescens (ATCC BAA-477) grew well at 100, 125 and 150 mg chloramphenicol/liter medium, but they did not grow on media containing chlortetracycline (100, 125, or 150 mg/L) or gentamicin (15, 25, or 35 mg/L). P. aeruginosa (ATCC 10145) grew well on media containing chloramphenicol or gentamicin, but not in the presence of chlortetracycline. P. carotovorum, E. coli, B. cereus and Staphylococcus spp. did not grow on any of the selective media tested.
JF  - International journal of food microbiology
AU  - Tournas, V H
AU  - Kohn, J S
AU  - Katsoudas, E J
AD  - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA. valerie.tournas@fda.hhs.gov
Y1  - 2007/08/15/
PY  - 2007
DA  - 2007 Aug 15
SP  - 83
EP  - 86
VL  - 118
IS  - 1
SN  - 0168-1605, 0168-1605
KW  - Anti-Bacterial Agents
KW  - 0
KW  - Culture Media
KW  - Gentamicins
KW  - Chloramphenicol
KW  - 66974FR9Q1
KW  - Chlortetracycline
KW  - WCK1KIQ23Q
KW  - Index Medicus
KW  - Chloramphenicol -- pharmacology
KW  - Chlortetracycline -- pharmacology
KW  - Mitosporic Fungi -- growth & development
KW  - Dose-Response Relationship, Drug
KW  - Mitosporic Fungi -- isolation & purification
KW  - Colony Count, Microbial
KW  - Microbial Sensitivity Tests
KW  - Gentamicins -- pharmacology
KW  - Food Microbiology
KW  - Anti-Bacterial Agents -- pharmacology
KW  - Fungi -- isolation & purification
KW  - Fungi -- growth & development
KW  - Culture Media -- chemistry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-09
N1  - Date created - 2007-08-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Adult mesenchymal stem cells: biological properties, characteristics, and applications in maxillofacial surgery.
AN  - 85395728; pmid-17656295
JF  - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
AU  - Shanti, Rabie M
AU  - Li, Wan-Ju
AU  - Nesti, Leon J
AU  - Wang, Xibin
AU  - Tuan, Rocky S
AD  - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 1640
EP  - 1647
VL  - 65
IS  - 8
SN  - 0278-2391, 0278-2391
KW  - National Library of Medicine
KW  - Adult Stem Cells: cytology
KW  - *Adult Stem Cells: physiology
KW  - Biocompatible Materials
KW  - Bone Substitutes
KW  - Cells, Cultured
KW  - Hematopoietic Stem Cells: cytology
KW  - Hematopoietic Stem Cells: physiology
KW  - Humans
KW  - Mesenchymal Stem Cells: cytology
KW  - *Mesenchymal Stem Cells: physiology
KW  - *Prosthesis Design: methods
KW  - *Reconstructive Surgical Procedures: methods
KW  - *Surgery, Oral: methods
KW  - *Tissue Engineering: methods
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LA  - English (eng)
DB  - ComDisDome
N1  - Date revised - 2011-12-15
N1  - Last updated - 2012-07-13
ER  - 



TY  - JOUR
T1  - Duration of therapy with metoclopramide: a prescription claims data study.
AN  - 70759161; 17436356
AB  - Metoclopramide-induced tardive dyskinesia is associated with cumulative drug exposure, which can result from prolonged use of the drug. We estimated therapy duration with metoclopramide, and measured the extent of therapy beyond the maximum time period of 12 weeks evaluated in the clinical trials and recommended in the label.
          Prescription claims for metoclopramide from 2002 to 2004 were extracted for participants residing throughout the US and contained within the Caremark pharmacy benefit manager (PBM) database. An episode of therapy was defined as one or a series of consecutive claims with no more than a 30-day lag between the dispensing date of a new claim and the ending date of the preceding claim. Episode duration was calculated by subtracting the start date from the end date for each episode. During the study period, almost 80% of participants (total = 200 907) had only one episode of therapy. The length of the longest episode for most patients (85%) varied from 1 to 90 days, yet 15% of the patients appeared to have received prescriptions for metoclopramide for a period longer than 90 days. Cumulative therapy for longer than 90 days was recorded for almost 20% of the patients.
          These results suggest that despite the known risk of tardive dyskinesia and the labeled recommendations on duration of metoclopramide use, many patients appear to use the drug for relatively long time periods beyond the labeled recommendations. Physicians should carefully consider the risk-benefit profile of the drug and, if possible, avoid increased risk of tardive dyskinesia due to prolonged exposure.
JF  - Pharmacoepidemiology and drug safety
AU  - Kaplan, Sigal
AU  - Staffa, Judy A
AU  - Dal Pan, Gerald J
AD  - Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, MD 20993, USA. sigal.kaplan@fda.hhs.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 878
EP  - 881
VL  - 16
IS  - 8
SN  - 1053-8569, 1053-8569
KW  - Antiemetics
KW  - 0
KW  - Metoclopramide
KW  - L4YEB44I46
KW  - Index Medicus
KW  - Risk
KW  - Drug Administration Schedule
KW  - Insurance, Pharmaceutical Services -- statistics & numerical data
KW  - Humans
KW  - Adult
KW  - Practice Guidelines as Topic
KW  - Databases, Factual
KW  - Aged
KW  - Middle Aged
KW  - Drug Labeling
KW  - Drug Prescriptions
KW  - Antiemetics -- administration & dosage
KW  - Metoclopramide -- administration & dosage
KW  - Dyskinesia, Drug-Induced -- etiology
KW  - Antiemetics -- adverse effects
KW  - Practice Patterns, Physicians' -- standards
KW  - Metoclopramide -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-23
N1  - Date created - 2007-07-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase.
AN  - 70745663; 17550941
AB  - Huntingon's disease is a progressive neurodegenerative disease arising from expansion of a polyglutamine (polyQ) tract in the protein huntingtin (Htt) resulting in aggregation of mutant Htt into nuclear and/or cytosolic inclusions in neurons. Mutant Htt affects multiple processes including protein degradation, transcription, signal transduction, fast axonal transport and endocytosis [reviewed in Ross, C.A. and Poirier, M.A. (2005) Opinion: what is the role of protein aggregation in neurodegeneration? Nat. Rev. Mol. Cell. Biol., 6, 891-898]. Here, we report that the endocytic and signal transduction scaffold intersectin (ITSN) increased aggregate formation by mutant Htt through activation of the c-Jun-NH(2)-terminal kinase (JNK)-MAPK pathway. Conversely, silencing ITSN or inhibiting JNK attenuated aggregate formation. Using a Drosophila model for polyQ repeat disease, we observed that ITSN enhanced polyQ-mediated neurotoxicity. A reciprocal relationship was observed between ITSN and Htt. While ITSN enhanced Htt aggregation and toxicity, Htt, in turn, inhibited the cooperativity between ITSN and the epidermal growth factor receptor signal transduction pathway. Finally, we observed that ITSN overexpression enhanced aggregation of polyQ-expanded androgen receptor (AR) as well as wild-type versions of both Htt and AR suggesting a broader involvement of ITSN in neurodegenerative diseases through destabilization of polyQ-containing proteins.
JF  - Human molecular genetics
AU  - Scappini, Erica
AU  - Koh, Tong-Wey
AU  - Martin, Negin P
AU  - O'Bryan, John P
AD  - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Y1  - 2007/08/01/
PY  - 2007
DA  - 2007 Aug 01
SP  - 1862
EP  - 1871
VL  - 16
IS  - 15
SN  - 0964-6906, 0964-6906
KW  - Adaptor Proteins, Vesicular Transport
KW  - 0
KW  - HTT protein, human
KW  - Huntingtin Protein
KW  - Nerve Tissue Proteins
KW  - Nuclear Proteins
KW  - Peptides
KW  - Recombinant Fusion Proteins
KW  - intersectin 1
KW  - polyglutamine
KW  - 26700-71-0
KW  - JNK Mitogen-Activated Protein Kinases
KW  - EC 2.7.11.24
KW  - Index Medicus
KW  - Microscopy, Confocal
KW  - Animals
KW  - Neurons -- metabolism
KW  - COS Cells
KW  - Enzyme Activation
KW  - Humans
KW  - Drosophila -- metabolism
KW  - Peptides -- metabolism
KW  - Mice
KW  - Recombinant Fusion Proteins -- metabolism
KW  - Cells, Cultured
KW  - Cercopithecus aethiops
KW  - Recombinant Fusion Proteins -- genetics
KW  - Drosophila -- genetics
KW  - Mutation
KW  - Signal Transduction
KW  - Nuclear Proteins -- analysis
KW  - Nerve Tissue Proteins -- analysis
KW  - Huntington Disease -- metabolism
KW  - Adaptor Proteins, Vesicular Transport -- metabolism
KW  - Nerve Tissue Proteins -- metabolism
KW  - Nuclear Proteins -- metabolism
KW  - JNK Mitogen-Activated Protein Kinases -- metabolism
KW  - Huntington Disease -- enzymology
KW  - Adaptor Proteins, Vesicular Transport -- genetics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-18
N1  - Date created - 2007-07-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Evaluation of immunotoxicity induced by pirimiphos-methyl in male Balb/c mice following exposure to for 28 days.
AN  - 70742113; 17654245
AB  - Pirimiphos-methyl (O-2-diethylamino-6-methylpyrimidin-4-yl O,O-dimethyl phosphorothioate: POM) is widely used organophosphorous (OP) insecticide as a grain protectant to control insects during storage. This study was carried out to assess the immunologic effects of POM in Balb/c mice after 28-day oral exposure. Three dose levels of POM (10, 60, or 120 mg/kg/day) were administered orally to mice for 4 weeks. At autopsy after 28-day exposure, there were significant decreases in relative spleen weight and splenic cellularity found at 120 mg POM, but body weight, relative thymic weight, thymic cellularity, and splenic and thymic subsets were not affected. T cell proliferation response induced by Con A was significantly decreased at all dosages though no statistical differences were observed in splenic B cell proliferation. Significant increases in the production of cytokines (IL-2, IL-4, IL-6, IFN-gamma, and IL-10) were evident on the whole, but the increase in production of inflammatory cytokines overwhelmed that of the T(H)1 cell suppressive cytokine (IL-10). The relative levels of three types of autoantibodies, anti-dsDNA, anti-histone, and antinuclear antibody (ANA) were dose-dependently decreased in serum. Oral exposure to POM induced a significant decrease in Immunoglobulin M production capability in Balb/c mice. This decrease in antibody production capability may result from disturbances in cytokine balance produced by splenic immune cells. These results show that POM may induce allergic responses by relatively enhancing T(H)2 development and additionally contribute to chronic inflammation by attracting macrophage by IFN-gamma.
JF  - Journal of toxicology and environmental health. Part A
AU  - Kim, Hyung Soo
AU  - Eom, Juno H
AU  - Cho, Hye-young
AU  - Cho, Young Joo
AU  - Kim, Ji Young
AU  - Lee, Jong Kwon
AU  - Kim, Seung-Hee
AU  - Park, Kui Lea
AD  - Immunotoxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea. kim_hs@kfda.go.kr
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 1278
EP  - 1287
VL  - 70
IS  - 15-16
SN  - 1528-7394, 1528-7394
KW  - Autoantibodies
KW  - 0
KW  - Cytokines
KW  - Immunoglobulin M
KW  - Insecticides
KW  - Organothiophosphorus Compounds
KW  - pirimiphos methyl
KW  - 29232-93-7
KW  - Index Medicus
KW  - Administration, Oral
KW  - Animals
KW  - Down-Regulation
KW  - Autoantibodies -- metabolism
KW  - Dose-Response Relationship, Drug
KW  - Autoantibodies -- blood
KW  - Disease Models, Animal
KW  - Mice
KW  - Up-Regulation
KW  - Mice, Inbred BALB C
KW  - Male
KW  - Organothiophosphorus Compounds -- immunology
KW  - Insecticides -- toxicity
KW  - Insecticides -- immunology
KW  - Cytokines -- drug effects
KW  - Insecticides -- administration & dosage
KW  - Immunoglobulin M -- metabolism
KW  - Cytokines -- metabolism
KW  - Organothiophosphorus Compounds -- administration & dosage
KW  - Spleen -- drug effects
KW  - Organothiophosphorus Compounds -- toxicity
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-21
N1  - Date created - 2007-07-26
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Inhalation of toluene diisocyanate vapor induces allergic rhinitis in mice.
AN  - 70726777; 17641053
AB  - Diisocyanates are the leading cause of occupational asthma, and epidemiological evidence suggests that occupational rhinitis is a comorbid and preceding condition in patients who develop asthma. The goal of the present studies was to develop and characterize a murine model of toluene diisocyanate (TDI)-induced rhinitis. Female C57BL/6 mice were exposed to workplace-relevant concentrations of TDI vapor via inhalation for 4 h/day for 12 days with or without a 2-wk rest period and TDI challenge. Mice exposed 12 consecutive weekdays to 50 parts per billion TDI vapor showed elevated total serum IgE and increased TDI-specific IgG titers. Breathing rates were decreased corresponding with increased inspiratory time. TDI exposure elevated IL-4, IL-5, IL-13, and IFN-gamma mRNA expression in the nasal mucosa, suggesting a mixed Th1/Th2 immune response. Expressions of mRNA for proinflammatory cytokines and adhesion molecules were also up-regulated. These cytokine changes corresponded with a marked influx of inflammatory cells into the nasal mucosa, eosinophils being the predominant cell type. Removal from exposure for 2 wk resulted in reduced Ab production, cytokine mRNA expression, and cellular inflammation. Subsequent challenge with 50 parts per billion TDI vapor resulted in robust up-regulation of Ab production, cytokine gene expression, as well as eosinophilic inflammation in the nasal mucosa. There were no associated changes in the lung. The present model shows that TDI inhalation induces immune-mediated allergic rhinitis, displaying the major features observed in human disease. Future studies will use this model to define disease mechanisms and examine the temporal/dose relationship between TDI-induced rhinitis and asthma.
JF  - Journal of immunology (Baltimore, Md. : 1950)
AU  - Johnson, Victor J
AU  - Yucesoy, Berran
AU  - Reynolds, Jeff S
AU  - Fluharty, Kara
AU  - Wang, Wei
AU  - Richardson, Diana
AU  - Luster, Michael I
AD  - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. vjohnson3@cdc.gov
Y1  - 2007/08/01/
PY  - 2007
DA  - 2007 Aug 01
SP  - 1864
EP  - 1871
VL  - 179
IS  - 3
SN  - 0022-1767, 0022-1767
KW  - Aerosols
KW  - 0
KW  - Cytokines
KW  - Immunoglobulin G
KW  - Toluene 2,4-Diisocyanate
KW  - 17X7AFZ1GH
KW  - Immunoglobulin E
KW  - 37341-29-0
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Th1 Cells -- immunology
KW  - Nasal Mucosa -- pathology
KW  - Animals
KW  - Occupational Diseases -- immunology
KW  - Immunoglobulin E -- blood
KW  - Random Allocation
KW  - Cytokines -- biosynthesis
KW  - Nasal Mucosa -- immunology
KW  - Th1 Cells -- metabolism
KW  - Mice
KW  - Nasal Mucosa -- metabolism
KW  - Immunoglobulin E -- biosynthesis
KW  - Th2 Cells -- pathology
KW  - Occupational Diseases -- chemically induced
KW  - Th2 Cells -- metabolism
KW  - Antibody Specificity
KW  - Th1 Cells -- pathology
KW  - Mice, Inbred C57BL
KW  - Occupational Diseases -- pathology
KW  - Administration, Inhalation
KW  - Th2 Cells -- immunology
KW  - Immunoglobulin G -- biosynthesis
KW  - Female
KW  - Toluene 2,4-Diisocyanate -- administration & dosage
KW  - Rhinitis, Allergic, Perennial -- immunology
KW  - Toluene 2,4-Diisocyanate -- immunology
KW  - Rhinitis, Allergic, Perennial -- pathology
KW  - Disease Models, Animal
KW  - Rhinitis, Allergic, Perennial -- chemically induced
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-17
N1  - Date created - 2007-07-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Estimating active bone marrow dose from occupational exposure to uranium at a former gaseous diffusion plant.
AN  - 70703885; 17622815
AB  - Active bone marrow absorbed doses were estimated for 581 workers as part of a nested case-control study of multiple myeloma mortality at the Oak Ridge Gaseous Diffusion Plant (K-25). Uranium urinalysis results obtained by fluorometric and gross alpha measurements were available for about 20% of the 581 study subjects. These data were used to determine intakes of uranium as a result of occupational exposure during operation of the K-25 facility. Uranium solubility was inferred from the observed urinary excretion rate, job titles, and department codes. Data suggest that most study subjects were exposed to uranyl fluoride, a relatively soluble uranium compound. The median cumulative bone marrow dose determined for subjects with bioassay data was 0.06 mGy with a geometric standard deviation of 4.48. Subjects without bioassay data were assigned cumulative bone marrow dose based upon job titles and department codes.
JF  - Health physics
AU  - Anderson, J L
AU  - Spitz, H B
AU  - Yiin, J H
AD  - Division of Surveillance, Hazard Evaluation, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH 45226, USA. JLAnderson@cdc.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 113
EP  - 119
VL  - 93
IS  - 2
SN  - 0017-9078, 0017-9078
KW  - Uranium
KW  - 4OC371KSTK
KW  - Index Medicus
KW  - Radiation Dosage
KW  - Humans
KW  - Body Burden
KW  - Occupational Exposure
KW  - Uranium -- urine
KW  - Bone Marrow -- radiation effects
KW  - Bone Marrow -- chemistry
KW  - Uranium -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-05
N1  - Date created - 2007-07-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Safety monitoring of drugs granted exclusivity under the Best Pharmaceuticals for Children Act: what the FDA has learned.
AN  - 70703666; 17632537
AB  - The Best Pharmaceuticals for Children Act (BPCA) was signed into law on 4 January 2002, shortly after the pediatric exclusivity provision of the Food and Drug Administration (FDA) Modernization Act expired on 1 January 2002. This Act provides six months of marketing exclusivity for a drug when a pharmaceutical company studies that drug for use in the pediatric population as requested by the FDA. Section 17 of the BPCA specifically requires that the FDA review all adverse events reported for drugs that receive pediatric exclusivity. In most of the cases, no unexpected adverse events were reported in the pediatric population; however, in some cases, this focused safety review provided information important to the safety of medication use in children.
JF  - Clinical pharmacology and therapeutics
AU  - Mathis, L L
AU  - Iyasu, S
AD  - Office of New Drugs, US Public Health Service, Silver Spring, Maryland, USA. Lisa.Mathis@fda.hhs.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 133
EP  - 134
VL  - 82
IS  - 2
SN  - 0009-9236, 0009-9236
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States
KW  - United States Food and Drug Administration
KW  - Humans
KW  - Child
KW  - Product Surveillance, Postmarketing -- methods
KW  - Government Regulation
KW  - Drug-Related Side Effects and Adverse Reactions -- prevention & control
KW  - Legislation, Drug
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-11
N1  - Date created - 2007-07-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Performance testing of NIOSH Method 5524/ASTM Method D-7049-04, for determination of metalworking fluids.
AN  - 70622748; 17577749
AB  - A performance test of NIOSH Method 5524/ASTM Method D-7049-04 for analysis of metalworking fluids (MWF) was conducted. These methods involve determination of the total and extractable weights of MWF samples; extractions are performed using a ternary blend of toluene:dichloromethane:methanol and a binary blend of methanol:water. Six laboratories participated in this study. A preliminary analysis of 20 blank samples was made to familiarize the laboratories with the procedure(s) and to estimate the methods' limits of detection/quantitation (LODs/LOQs). Synthetically generated samples of a semisynthetic MWF aerosol were then collected on tared polytetrafluoroethylene (PTFE) filters and analyzed according to the methods by all participants. Sample masses deposited (approximately 400-500 micro g) corresponded to amounts expected in an 8-hr shift at the NIOSH recommended exposure levels (REL) of 0.4 mg/m(3) (thoracic) and 0.5 mg/m(3) (total particulate). The generator output was monitored with a calibrated laser particle counter. One laboratory significantly underreported the sampled masses relative to the other five labs. A follow-up study compared only gravimetric results of this laboratory with those of two other labs. In the preliminary analysis of blanks; the average LOQs were 0.094 mg for the total weight analysis and 0.136 mg for the extracted weight analyses. For the six-lab study, the average LOQs were 0.064 mg for the total weight analyses and 0.067 mg for the extracted weight analyses. Using ASTM conventions, h and k statistics were computed to determine the degree of consistency of each laboratory with the others. One laboratory experienced problems with precision but not bias. The precision estimates for the remaining five labs were not different statistically (alpha = 0.005) for either the total or extractable weights. For all six labs, the average fraction extracted was > or =0.94 (CV = 0.025). Pooled estimates of the total coefficients of variation of analysis were 0.13 for the total weight samples and 0.13 for the extracted weight samples. An overall method bias of -5% was determined by comparing the overall mean concentration reported by the participants to that determined by the particle counter. In the three-lab follow-up study, the nonconsistent lab reported results that were unbiased but statistically less precise than the others; the average LOQ was 0.133 mg for the total weight analyses. It is concluded that aerosolized MWF sampled at concentrations corresponding to either of the NIOSH RELs can generally be shipped unrefrigerated, stored refrigerated up to 7 days, and then analyzed quantitatively and precisely for MWF using the NIOSH/ASTM procedures.
JF  - Journal of occupational and environmental hygiene
AU  - Glaser, Robert
AU  - Kurimo, Robert
AU  - Shulman, Stanley
AD  - National Institute for Occupational Safety and Health. Cincinnati, OH 45226, USA. rag3@cdc,gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 583
EP  - 595
VL  - 4
IS  - 8
SN  - 1545-9624, 1545-9624
KW  - Aerosols
KW  - 0
KW  - Air Pollutants, Occupational
KW  - Index Medicus
KW  - United States
KW  - Lubrication
KW  - Reproducibility of Results
KW  - National Institute for Occupational Safety and Health (U.S.)
KW  - Metallurgy
KW  - Industrial Oils -- analysis
KW  - Air Pollutants, Occupational -- analysis
KW  - Environmental Monitoring -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-04
N1  - Date created - 2007-06-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Hexavalent chromium exposures and exposure-control technologies in American enterprise: results of a NIOSH field research study.
AN  - 70619896; 17577750
AB  - The National Institute for Occupational Safety and Health (NIOSH) conducted 21 field surveys in selected industries to characterize workers' exposures to hexavalent chromium-containing airborne particulate and to evaluate existing technologies for controlling these exposures. Hexavalent chromium Cr(VI) is a respiratory irritant and chronic inhalation may cause lung cancer. Primary evaluation methods included collection of full work shift, personal breathing-zone (PBZ) air samples for Cr(VI), measurement of ventilation system parameters, and documentation of processes and work practices. This study emphasized evaluation of engineering exposure control measures, so PBZ exposures were measured on the outside of personal protective equipment, for example, respirators. Field surveys were conducted in two chromium electroplating facilities, including one where full-shift PBZ exposures to Cr(VI) ranged from 3.0 to 16 times the 1 micro g/m(3)NIOSH recommended exposure limit (REL) despite several engineering controls on the plating tanks. At a painting and coating facility that used Cr(VI)-containing products, full-shift exposures of painters and helpers (2.4 to 55 micro g/m(3)) exceeded the REL, but LEV effectiveness was limited. Other operations evaluated included welding in construction; metal cutting operations on chromium-containing materials in ship breaking; chromate-paint removal with abrasive blasting; atomized alloy-spray coating; foundry operations; printing; and the manufacture of refractory brick, colored glass, prefabricated concrete products, and treated wood products. NIOSH researchers concluded that, in many of the evaluated processes, Cr(VI) exposures at or below the current NIOSH REL are achievable. However, for some processes, it is unclear whether controlling exposures to this range is consistently achievable without respirator use. Some operations involving the application of coatings and finishes may be among those most difficult to control to this range. Most operations judged to be moderately difficult to control to this range involve joining and cutting metals with relatively high chromium content. Nonetheless, exposures in a wide variety of other processes were judged more easily controllable to the current REL or below, or were found to be minimal, including some operations meeting the general descriptions named above but with different specific operating parameters producing lower Cr(VI) exposures.
JF  - Journal of occupational and environmental hygiene
AU  - Blade, L M
AU  - Yencken, M Story
AU  - Wallace, M E
AU  - Catalano, J D
AU  - Khan, A
AU  - Topmiller, J L
AU  - Shulman, S A
AU  - Martinez, A
AU  - Crouch, K G
AU  - Bennett, J S
AD  - National Institute for Occupational Safety and Health. Cincinnati, OH 45226, USA. LMB1@cdc,gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 596
EP  - 618
VL  - 4
IS  - 8
SN  - 1545-9624, 1545-9624
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Chromium
KW  - 0R0008Q3JB
KW  - chromium hexavalent ion
KW  - 18540-29-9
KW  - Index Medicus
KW  - United States
KW  - Environmental Monitoring
KW  - Respiratory Protective Devices
KW  - Ventilation
KW  - Inhalation Exposure -- prevention & control
KW  - Inhalation Exposure -- analysis
KW  - Skin Absorption
KW  - Humans
KW  - Paint
KW  - Electroplating
KW  - National Institute for Occupational Safety and Health (U.S.)
KW  - Industry
KW  - Occupational Exposure -- prevention & control
KW  - Chromium -- analysis
KW  - Air Pollutants, Occupational -- analysis
KW  - Occupational Exposure -- analysis
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-04
N1  - Date created - 2007-06-19
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Review of chamber design requirements for testing of personal protective clothing ensembles.
AN  - 70612251; 17558802
AB  - This review focuses on the physical requirements for conducting ensemble testing and describes the salient issues that organizations involved in the design, test, or certification of personal protective equipment (PPE) and protective clothing ensembles need to consider for strategic planning. Several current and proposed PPE ensemble test practices and standards were identified. The man-in-simulant test (MIST) is the primary procedure used by the military to evaluate clothing ensembles for protection against chemical and biological warfare agents. MIST has been incorporated into the current editions of protective clothing and equipment standards promulgated by the National Fire Protection Association (NFPA). ASTM has recently developed a new test method (ASTM F 2588-06) for MIST evaluation of protective ensembles. Other relevant test methods include those described in International Organization for Standardization (ISO) standards. The primary differences among the test methods were the choice of test challenge material (e.g., sulfur hexafluoride, methyl salicylate, sodium chloride particles, corn oil, fluorophore-impregnated silica) and the exercise protocol for the subject(s). Although ensemble test methods and standards provide detailed descriptions of the test procedures, none give specific requirements for chamber design. A literature survey identified 28 whole-body exposure chambers that have been or could potentially be used for testing protective clothing ensembles using human test subjects. Median chamber size, median floor space, and median volume per subject were calculated from 15 chambers (involving human test subjects), where size information is available. Based on the literature survey of existing chambers and the review of the current and proposed standards and test methods, chamber design requirements will be dictated by the test methods selected. Due to widely different test conditions for aerosol/particulate and vapor ensemble testing, it is unlikely that a single chamber could accommodate all types of ensemble testing. With increasing use of the MIST protocol by NFPA for CBRN certification of structural firefighting gear and protective ensembles for first responders, the need for MIST laboratory capability is clear. However, existing chambers can likely be adapted to accommodate MIST with some modifications.
JF  - Journal of occupational and environmental hygiene
AU  - Gao, Pengfei
AU  - King, William P
AU  - Shaffer, Ronald
AD  - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health. Pittsburgh, PA 15236, USA.
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 562
EP  - 571
VL  - 4
IS  - 8
SN  - 1545-9624, 1545-9624
KW  - Aerosols
KW  - 0
KW  - Air Pollutants
KW  - Allergens
KW  - Index Medicus
KW  - Air Pollutants -- pharmacokinetics
KW  - Humans
KW  - Allergens -- toxicity
KW  - Equipment Failure
KW  - Environmental Exposure -- prevention & control
KW  - Air Pollutants -- toxicity
KW  - Materials Testing -- methods
KW  - Materials Testing -- instrumentation
KW  - Protective Clothing -- standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-04
N1  - Date created - 2007-06-11
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
J Occup Environ Hyg. 2007 Dec;4(12):D135; author reply D135 [17943584]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Identification of Shiga toxigenic Escherichia coli seropathotypes A and B by multiplex PCR.
AN  - 70506913; 17383154
AB  - A multiplex PCR assay was developed to identify the six clinically important enterohemorrhagic Escherichia coli (EHEC) serotypes classified in seropathotypes A and B and to differentiate these from Shiga toxigenic E. coli. The assay simultaneously detects genes for Shiga toxin (stx) and intimin (eae), including allelic variants of both genes, 16S internal amplification control, as well as unique sequences in the wzx genes that are specific for serotypes O157, O26, O111, O103, O121 and O145. PCR analysis of 40 representative strains showed that the assay correctly identified the virulence genes, if present, and the respective O antigen type of all the strains, including some atypical EHEC, as well as enteropathogenic E. coli and E. coli strains examined.
JF  - Molecular and cellular probes
AU  - Monday, S R
AU  - Beisaw, A
AU  - Feng, P C H
AD  - Division of Microbiological Studies, US Food and Drug Administration, College Park, MD 20740, USA.
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 308
EP  - 311
VL  - 21
IS  - 4
SN  - 0890-8508, 0890-8508
KW  - DNA, Bacterial
KW  - 0
KW  - Shiga Toxin
KW  - 75757-64-1
KW  - Index Medicus
KW  - Escherichia coli -- isolation & purification
KW  - Shiga Toxin -- genetics
KW  - Escherichia coli -- classification
KW  - DNA, Bacterial -- genetics
KW  - Polymerase Chain Reaction -- methods
KW  - Escherichia coli -- genetics
KW  - DNA, Bacterial -- analysis
KW  - Bacterial Typing Techniques
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-31
N1  - Date created - 2007-05-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Occurrence of Listeria monocytogenes in sandwiches available to hospital patients in Wales, United Kingdom.
AN  - 68239567; 17803157
AB  - A survey for the presence of Listeria monocytogenes in hospital sandwiches was carried out in Wales, United Kingdom, between October 2005 and March 2006. The main aim of the survey was to establish the baseline rate of L. monocytogenes in hospital sandwiches after an outbreak of listeriosis among hospital patients in 2004 was epidemiologically linked to the consumption of contaminated sandwiches. The overall positive rate found in hospital sandwiches was 2.84% for enriched culture and 0.21% for direct counts. The unsatisfactory rate (> 100 CFU/g) for hospital sandwiches was 0.1%. The conclusion was that hospital sandwiches generally presented a low hazard to consumers. In addition to establishing the overall baseline and the unsatisfactory rates in hospital sandwiches in Wales for this period, the study compared the rates found in hospital sandwiches with the rates found in sandwiches simultaneously sampled from general retailers. The aim of this part of the study was to compare the relative rates associated with hospital and retail sandwiches to ascertain if there were any differences in the positive rate. The conclusion of this part of the survey was that there was not a statistically significant difference in rates between sandwiches sampled from hospitals and those sampled from general retailers.
JF  - Journal of food protection
AU  - Meldrum, R J
AU  - Smith, R M M
AD  - Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK. richard.meldrum@nphs.wales.nhs.uk
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 1958
EP  - 1960
VL  - 70
IS  - 8
SN  - 0362-028X, 0362-028X
KW  - Index Medicus
KW  - Humans
KW  - Colony Count, Microbial
KW  - Wales
KW  - Disease Outbreaks
KW  - Prevalence
KW  - Listeria monocytogenes -- isolation & purification
KW  - Food Microbiology
KW  - Consumer Product Safety
KW  - Food Contamination -- analysis
KW  - Food Service, Hospital -- standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-25
N1  - Date created - 2007-09-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Salmonella and Campylobacter in United Kingdom retail raw chicken in 2005.
AN  - 68238188; 17803153
AB  - The United Kingdom Food Standards Agency commissioned a survey of Salmonella and Campylobacter in raw, whole chickens at retail in Wales and Northern Ireland between March and December 2005 to measure the baseline prevalence rates of these two significant pathogens. In total, 877 retail samples were examined for Campylobacter and Salmonella by enrichment methods. Overall contamination rates of 70.2% for Campylobacter and 4.0% for Salmonella were found. There was a statistically significant difference in Campylobacter rates between fresh and frozen samples, with fresh samples having a higher rate. There was no statistically significant difference between samples taken from retailers and butchers. Campylobacter was significantly more common in Northern Ireland than in Wales. Salmonella was significantly more common in Wales. The findings indicate the need for further investigation to explore why measures that have been successful in reducing Salmonella in the United Kingdom in recent years have failed to contribute to the control of Campylobacter. Identifying the factors responsible could lead to the introduction of more effective controls throughout the industry.
JF  - Journal of food protection
AU  - Meldrum, Richard J
AU  - Wilson, Ian G
AD  - Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth, CF64 2XX, UK. richard.meldrum@nphs.wales.nhs.uk
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 1937
EP  - 1939
VL  - 70
IS  - 8
SN  - 0362-028X, 0362-028X
KW  - Index Medicus
KW  - Animals
KW  - Humans
KW  - Colony Count, Microbial
KW  - Meat -- microbiology
KW  - United Kingdom
KW  - Prevalence
KW  - Consumer Product Safety
KW  - Food Contamination -- analysis
KW  - Chickens -- microbiology
KW  - Salmonella -- isolation & purification
KW  - Campylobacter -- isolation & purification
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-25
N1  - Date created - 2007-09-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - FDA drug approval summary: pegaspargase (oncaspar) for the first-line treatment of children with acute lymphoblastic leukemia (ALL).
AN  - 68230663; 17766659
AB  - On July 24, 2006, the U.S. Food and Drug Administration granted approval to pegaspargase (Oncaspar; Enzon Pharmaceuticals, Inc., Bridgewater, NJ; hereafter, O) for the first-line treatment of patients with acute lymphoblastic leukemia (ALL) as a component of a multiagent chemotherapy regimen. O was previously approved in February 1994 for the treatment of patients with ALL who were hypersensitive to native forms of L-asparaginase. The trial supporting this new indication was an open label, randomized, multicenter clinical trial that enrolled 118 children (age, 1-9 years) with previously untreated, standard risk ALL. Patients received either native Escherichia coli asparaginase (Elspar; Merck, Whitehouse Station, NJ; hereafter, E) or O along with multiagent chemotherapy during remission induction and delayed intensification (DI) phases of treatment. O, at a dose of 2,500 IU/m(2), was administered i.m. on day 3 of the 4-week induction phase and on day 3 of each of two 8-week DI phases. E, at a dose of 6,000 IU/m(2), was administered i.m. three times weekly for nine doses during induction and for six doses during each DI phase. This study allowed direct comparison of O and E for asparagine depletion, asparaginase activity, and development of asparaginase antibodies. An unplanned comparison of event-free survival (EFS) was conducted to rule out a deleterious O efficacy effect. Following induction and DI treatment there was complete (0.03 IU/ml in O-treated subjects was greater than the number of days in E-treated subjects during both the induction and DI phases of treatment. There was no correlation, however, between asparaginase activity and serum asparagine levels, making the former determination less clinically relevant. Using the protocol-prespecified threshold for a positive result of >2.5 times the control, 7 of 56 (12%) O subjects tested at any time during the study demonstrated antiasparaginase antibodies and 16 of 57 (28%) E subjects tested at any time during the study had antiasparaginase antibodies. In both study arms EFS was in the range of 80% at 3 years. The most serious, sometimes fatal, O toxicities were anaphylaxis, other serious allergic reactions, thrombosis (including sagittal sinus thrombosis), pancreatitis, glucose intolerance, and coagulopathy. The most common adverse events were allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, central nervous system thrombosis, coagulopathy, hyperbilirubinemia, and elevated transaminases. Disclosure of potential conflicts of interest is found at the end of this article.
JF  - The oncologist
AU  - Dinndorf, Patricia Anne
AU  - Gootenberg, Joseph
AU  - Cohen, Martin H
AU  - Keegan, Patricia
AU  - Pazdur, Richard
AD  - U.S. Food and Drug Administration, White Oak Campus, 10903 New Hampshire Avenue, Building 22, Room 2102, Silver Spring, Maryland 20993-0002, USA. martin.cohen@fda.hhs.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 991
EP  - 998
VL  - 12
IS  - 8
SN  - 1083-7159, 1083-7159
KW  - Antibodies
KW  - 0
KW  - Antineoplastic Agents
KW  - Polyethylene Glycols
KW  - 30IQX730WE
KW  - Asparagine
KW  - 7006-34-0
KW  - pegaspargase
KW  - 7D96IR0PPM
KW  - Asparaginase
KW  - EC 3.5.1.1
KW  - Index Medicus
KW  - United States
KW  - Disease-Free Survival
KW  - Humans
KW  - Asparagine -- blood
KW  - Child
KW  - Child, Preschool
KW  - Infant
KW  - United States Food and Drug Administration
KW  - Antibodies -- blood
KW  - Drug Approval
KW  - Asparagine -- cerebrospinal fluid
KW  - Treatment Outcome
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - Female
KW  - Male
KW  - Asparaginase -- adverse effects
KW  - Polyethylene Glycols -- therapeutic use
KW  - Asparaginase -- antagonists & inhibitors
KW  - Polyethylene Glycols -- adverse effects
KW  - Asparaginase -- blood
KW  - Asparaginase -- immunology
KW  - Antineoplastic Agents -- therapeutic use
KW  - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
KW  - Asparaginase -- therapeutic use
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+drug+approval+summary%3A+pegaspargase+%28oncaspar%29+for+the+first-line+treatment+of+children+with+acute+lymphoblastic+leukemia+%28ALL%29.&rft.au=Dinndorf%2C+Patricia+Anne%3BGootenberg%2C+Joseph%3BCohen%2C+Martin+H%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Dinndorf&rft.aufirst=Patricia&rft.date=2007-08-01&rft.volume=12&rft.issue=8&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-31
N1  - Date created - 2007-09-03
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Pulmonary toxicity of Expancel microspheres in the rat.
AN  - 68222586; 17763284
AB  - Expancel microspheres are thermoplastic microspheres enclosing hydrocarbon. These microspheres expand when heated, producing many applications. Because they have unknown biological persistence and toxicity, we investigated the toxicity of two unexpanded (11.1 and 15.4 micro m mean diameter) and two expanded (3.1 and 5.5 micro m mass median aerodynamic diameter) Expancel microspheres in intratracheally-instilled, male, Sprague-Dawley rats. Pulmonary histopathology was evaluated at 28 days postexposure. Bronchoalveolar lavage fluid was evaluated at days 1, 7, 14, and 28 days postexposure. Crystalline silica was the positive control. By histopathology, both unexpanded and expanded microspheres caused granulomatous bronchopneumonia characterized by macrophages and giants cells, suggesting a persistent foreign body response. Expanded, but not unexpanded microspheres, also caused eosinophilic bronchitis and bronchiolitis, mucous metaplasia of airways and organized granulomatous inflammation with associated fibrosis and frequent airway obstruction. In contrast, alveolar macrophage activation, polymorphonuclear leukocytes, LDH and albumin in bronchoalveolar laveage fluid were initially elevated but returned to near control levels at 28 days, and did not reflect the persistent granulomatous bronchopneumonia caused by Expancel microspheres. These findings emphasize the importance of histopathology for evaluating pulmonary toxicity, suggest that Expancel microspheres are a potential occupational hazard, and indicate a need for additional studies on their potential pulmonary toxicity. [Supplementary materials are available for this article. Go to the publisher's online edition of Toxicology Pathology for the following free supplemental resources: motion within unexpected microspheres in H&E-stained lung (supplementary Figure 1); broncholar epithelium 28 days following exposure to 551 DE 20 microspheres (supplementary Figure 2); membrane ruffling and some instances of phagocytosis within the microspheres (supplementary Figure 3)]
JF  - Toxicologic pathology
AU  - Porter, Dale W
AU  - Hubbs, Ann F
AU  - Baron, Paul A
AU  - Millecchia, Lyndell L
AU  - Wolfarth, Michael G
AU  - Battelli, Lori A
AU  - Schwegler-Berry, Diane E
AU  - Beighley, Christopher M
AU  - Andrew, Michael E
AU  - Castranova, Vincent
AD  - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA. DPorter@cdc.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 702
EP  - 714
VL  - 35
IS  - 5
SN  - 0192-6233, 0192-6233
KW  - Air Pollutants, Occupational
KW  - 0
KW  - Albumins
KW  - L-Lactate Dehydrogenase
KW  - EC 1.1.1.27
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Rats, Sprague-Dawley
KW  - Neutrophils -- pathology
KW  - Albumins -- analysis
KW  - Bronchoalveolar Lavage Fluid -- chemistry
KW  - Particle Size
KW  - L-Lactate Dehydrogenase -- analysis
KW  - Lymph Nodes -- pathology
KW  - Cell Differentiation -- drug effects
KW  - Bronchoalveolar Lavage Fluid -- cytology
KW  - Male
KW  - Lung -- drug effects
KW  - Lung -- pathology
KW  - Air Pollutants, Occupational -- toxicity
KW  - Microspheres
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Incorporation+of+an+Internal+Ribosome+Entry+Site-Dependent+Mechanism+in+Arsenic-Induced+GADD45+alpha+Expression&rft.au=Chang%2C+Qingshan%3BBhatia%2C+Deepak%3BZhang%2C+Yadong%3BMeighan%2C+Terry%3BCastranova%2C+Vince%3BShi%2C+Xianglin%3BChen%2C+Fei&rft.aulast=Chang&rft.aufirst=Qingshan&rft.date=2007-07-01&rft.volume=67&rft.issue=13&rft.spage=6146&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-02
N1  - Date created - 2007-08-31
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Development of a gas chromatographic test for the quantitation of the biomarker 2-butoxyacetic acid in urine samples.
AN  - 68215033; 17725869
AB  - An accurate and precise method is developed and evaluated for the detection and quantitation of 2-butoxyacetic acid (2-BAA), a metabolite and biomarker for human exposure to 2-butoxyethanol. The solvent 2-butoxyethanol (2-BE) is extensively used in various industrial and domestic applications, and it is a health concern owing to its toxicity. Sample preparation consists of liquid-liquid extraction (LLE) of urine, then esterification of 2-BAA to produce the ethyl ester analog. The gas chromatographic conditions utilize a dimethyl polysiloxane phase (HP-1) capillary column and a mass spectrometer (MS) for detection of the analyte. Validation of this method includes a recovery study using fortified urine samples, which demonstrated good accuracy and precision; recovery varied between 100% and 102% of theory, with relative standard deviations of replicate samples at 2.8% and less. The detection limit of this method ranges from 0.005 to 0.015 microg/mL equivalent level of 2-BAA in urine.
JF  - Journal of chromatographic science
AU  - B'Hymer, C
AD  - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Taft Laboratory, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. cbhymer@cdc.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 422
EP  - 427
VL  - 45
IS  - 7
SN  - 0021-9665, 0021-9665
KW  - Biomarkers
KW  - 0
KW  - Glycolates
KW  - n-butoxyacetic acid
KW  - 2516-93-0
KW  - Index Medicus
KW  - Sensitivity and Specificity
KW  - Humans
KW  - Reference Standards
KW  - Biomarkers -- urine
KW  - Glycolates -- urine
KW  - Chromatography, Gas -- methods
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68215033?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatographic+science&rft.atitle=Development+of+a+gas+chromatographic+test+for+the+quantitation+of+the+biomarker+2-butoxyacetic+acid+in+urine+samples.&rft.au=B%27Hymer%2C+C&rft.aulast=B%27Hymer&rft.aufirst=C&rft.date=2007-08-01&rft.volume=45&rft.issue=7&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatographic+science&rft.issn=00219665&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-01
N1  - Date created - 2007-08-29
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Drug hepatotoxicity from a regulatory perspective.
AN  - 68204370; 17723917
AB  - This article summarizes problems of drug-induced liver injury (DILI), as seen from the perspective of the Food and Drug Administration (FDA). After brief consideration of the scope of FDA activities and processes of new drug development and review for possible approval of products for clinical use and marketing, some of the perceived current problems in detection, confirmation, close observation, differential diagnosis, and follow-up of cases of possible DILI in controlled clinical trials are described. Readers are invited to consider possible solutions to the many problems of DILI, propose ways to support research in the field, and keep abreast of progress by visiting the web site at www.fda.gov/cder/livertox.
JF  - Clinics in liver disease
AU  - Senior, John R
AD  - Center for Drug Evaluation and Research, Food and Drug Administration, Federal Research Center at White Oak, Building 22:3482, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA. john.senior@fda.hhs.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 507
EP  - 24, vi
VL  - 11
IS  - 3
SN  - 1089-3261, 1089-3261
KW  - Index Medicus
KW  - United States
KW  - Drug Evaluation
KW  - United States Food and Drug Administration
KW  - Humans
KW  - Clinical Trials as Topic
KW  - Drug Design
KW  - Drug and Narcotic Control
KW  - Drug-Related Side Effects and Adverse Reactions
KW  - Chemical and Drug Induced Liver Injury
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68204370?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+liver+disease&rft.atitle=Drug+hepatotoxicity+from+a+regulatory+perspective.&rft.au=Senior%2C+John+R&rft.aulast=Senior&rft.aufirst=John&rft.date=2007-08-01&rft.volume=11&rft.issue=3&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Clinics+in+liver+disease&rft.issn=10893261&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-08
N1  - Date created - 2007-08-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Oxidation of 2-mercaptobenzothiazole in latex gloves and its possible haptenation pathway.
AN  - 68182083; 17630704
AB  - The rubber accelerator, 2-mercaptobenzothiazole (MBT), has been reported to cause allergic contact dermatitis from gloves and other rubber products, but its chemical fate when exposed to occupational oxidants and the mechanism of its pathogenesis are not known. It was hypothesized that the thiol group is critical to MBT's (its oxidation products or metabolites) covalent binding and/or haptenation to nucleophilic protein residues. Oxidative transformation of MBT to the disulfide 2,2'-dithiobis(benzothiazole) (MBTS) was observed within the glove matrix when hypochlorous acid, iodine, and hydrogen peroxide were used as oxidants. Cysteine reduced MBTS to MBT with subsequent formation of the mixed disulfide 2-amino-3-(benzothiazol-2-yl disulfanyl)propionic acid which was identified and characterized. Spectrophotometry and mass spectrometry experiments demonstrated the simultaneous reduction of MBTS and disulfide formation with Cys34 on bovine serum albumin, suggesting a potential route of protein haptenation through covalent bonding between protein cysteinyl residues and the MBT/MBTS thiol moiety. Metabolism of MBT using isoniazid and dexamethasone-induced rat liver microsomes, to give a protein reactive epoxide intermediate and provide an alternative protein haptenation mechanism, was not observed. The data suggest that the critical functional group on MBT is the thiol, and haptenation is via the formation of mixed disulfides between the thiol group on MBT and a protein sulfhydryl group.
JF  - Chemical research in toxicology
AU  - Chipinda, Itai
AU  - Hettick, Justin M
AU  - Simoyi, Reuben H
AU  - Siegel, Paul D
AD  - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA.
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 1084
EP  - 1092
VL  - 20
IS  - 8
SN  - 0893-228X, 0893-228X
KW  - Benzothiazoles
KW  - 0
KW  - Disulfides
KW  - Haptens
KW  - Latex
KW  - captax
KW  - 5RLR54Z22K
KW  - Cysteine
KW  - K848JZ4886
KW  - Index Medicus
KW  - Rats
KW  - Oxidation-Reduction
KW  - Animals
KW  - Rats, Sprague-Dawley
KW  - Disulfides -- chemistry
KW  - Cysteine -- chemistry
KW  - Spectrophotometry
KW  - Time Factors
KW  - Chromatography, High Pressure Liquid
KW  - Binding Sites
KW  - Gloves, Protective
KW  - Haptens -- metabolism
KW  - Haptens -- chemistry
KW  - Metabolic Networks and Pathways
KW  - Latex -- toxicity
KW  - Benzothiazoles -- toxicity
KW  - Dermatitis, Allergic Contact -- pathology
KW  - Latex -- chemistry
KW  - Benzothiazoles -- chemistry
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68182083?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Oxidation+of+2-mercaptobenzothiazole+in+latex+gloves+and+its+possible+haptenation+pathway.&rft.au=Chipinda%2C+Itai%3BHettick%2C+Justin+M%3BSimoyi%2C+Reuben+H%3BSiegel%2C+Paul+D&rft.aulast=Chipinda&rft.aufirst=Itai&rft.date=2007-08-01&rft.volume=20&rft.issue=8&rft.spage=1084&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-28
N1  - Date created - 2007-08-21
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk.
AN  - 68179865; 17557904
AB  - The double-strand break DNA repair (DSBR) pathway is implicated in maintaining genomic stability and therefore could affect bladder cancer risk. Here we present data evaluating 39 single-nucleotide polymorphisms (SNPs) in seven candidate genes whose products are involved in DNA break sensing (NBS1, BRCA1 interacting genes BRIP1 and ZNF350), non-homologous end-joining (NHEJ) DNA repair (XRCC4) and homologous recombination (HR) repair (RAD51, XRCC2 and XRCC3). SNPs for RAD51 and XRCC2 covered most of the common variation. Associations with bladder cancer risk were evaluated in 1,150 newly diagnosed cases of urinary bladder transitional cell carcinomas and 1,149 controls conducted in Spain during 1997-2001. We found that the genetic variants evaluated significantly contributed to bladder cancer risk (global likelihood ratio test P = 0.01). Subjects with the ZNF350 R501S (rs2,278,415) variant allele showed significantly reduced risk compared with common homozygote variants, odds ratio (OR) [95% confidence interval (95% CI)]: 0.76 (0.62-0.93) per variant allele. Carriers of a putative functional SNP in intron 7 of XRCC4 (rs1,805,377) had significantly increased bladder cancer risk compared with common homozygotes: 1.33 (1.08-1.64) per variant allele. Lastly, XRCC2 homozygote variants for three promoter SNPs (rs10,234,749, rs6,464,268, rs3,218,373) and one non-synonymous SNP (rs3,218,536, R188H) were associated with reduced bladder cancer risk (ORs ranging from 0.36 to 0.50 compared with common homozygotes). Meta-analysis for XRCC3 T241M (rs861,539) had a significant small increase in risk among homozygote variants: OR (95% CI) = 1.17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations.
JF  - Carcinogenesis
AU  - Figueroa, Jonine D
AU  - Malats, Núria
AU  - Rothman, Nathaniel
AU  - Real, Francisco X
AU  - Silverman, Debra
AU  - Kogevinas, Manolis
AU  - Chanock, Stephen
AU  - Yeager, Meredith
AU  - Welch, Robert
AU  - Dosemeci, Mustafa
AU  - Tardón, Adonina
AU  - Serra, Consol
AU  - Carrato, Alfredo
AU  - García-Closas, Reina
AU  - Castaño-Vinyals, Gemma
AU  - García-Closas, Montserrat
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. figueroaj@mail.nih.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 1788
EP  - 1793
VL  - 28
IS  - 8
SN  - 0143-3334, 0143-3334
KW  - Index Medicus
KW  - Polymorphism, Single Nucleotide
KW  - Aged, 80 and over
KW  - Risk Factors
KW  - Humans
KW  - Adult
KW  - Aged
KW  - Middle Aged
KW  - Male
KW  - Female
KW  - DNA Repair -- genetics
KW  - Genetic Variation
KW  - Urinary Bladder Neoplasms -- genetics
KW  - Genetic Predisposition to Disease
KW  - DNA Breaks, Double-Stranded
KW  - Carcinoma, Transitional Cell -- genetics
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Evaluation+of+genetic+variation+in+the+double-strand+break+repair+pathway+and+bladder+cancer+risk.&rft.au=Figueroa%2C+Jonine+D%3BMalats%2C+N%C3%BAria%3BRothman%2C+Nathaniel%3BReal%2C+Francisco+X%3BSilverman%2C+Debra%3BKogevinas%2C+Manolis%3BChanock%2C+Stephen%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BDosemeci%2C+Mustafa%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BCasta%C3%B1o-Vinyals%2C+Gemma%3BGarc%C3%ADa-Closas%2C+Montserrat&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2007-08-01&rft.volume=28&rft.issue=8&rft.spage=1788&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-19
N1  - Date created - 2007-08-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Effect of particulate matter air pollution on hospital admissions and medical visits for lung and heart disease in two southeast Idaho cities.
AN  - 68149095; 17299531
AB  - Few, if any, published time series studies have evaluated the effects of particulate matter air exposures by combining hospital admissions with medical visit data for smaller populations. We investigated the relationship between daily particulate matter (<10 microm in aerometric diameter or PM10) exposures with admissions and medical visits (emergency room, urgent care, and family practice) for respiratory and cardiovascular disease in Pocatello and Chubbuck, Idaho (population about 60,000), from November 1994 through March 2000. Within generalized linear models, time, weather, influenza, and day-of-week effects were controlled. In single-pollutant models, respiratory disease admissions and visits increased (7.1-15.4% per 50 microg/m3 PM10) for each age group analyzed, with the highest increases in two groups, children and especially the elderly. Statistical analyses suggest that the results probably did not occur by chance. Sensitivity analyses did not provide strong evidence that the respiratory disease effect estimates were sensitive to reasonable changes in the final degrees of freedom choice for time and weather effects. No strong evidence of confounding by NO2 and SO2 was found from results of multi-pollutant models. Ozone and carbon monoxide data were not available to include multi-pollutant models, but evidence suggests that they were not a problem. Unexpectedly, evidence of an association between PM10 with cardiovascular disease was not found, possibly due to the lifestyles of the mostly Mormon study population. Successful time series analyses can be performed on smaller populations if diverse, centralized databases are available. Hospitals that offer urgent or other primary care services may be a rich source of data for researchers. Using data that potentially represented a wide-range of disease severity, the findings provide evidence that evaluating only hospital admissions or emergency room visit effects may underestimate the overall morbidity due to acute particulate matter exposures. Further work is planned to test this conclusion.
JF  - Journal of exposure science & environmental epidemiology
AU  - Ulirsch, Gregory V
AU  - Ball, Louise M
AU  - Kaye, Wendy
AU  - Shy, Carl M
AU  - Lee, Carolyn V
AU  - Crawford-Brown, Douglas
AU  - Symons, Michael
AU  - Holloway, Tracey
AD  - Division of Health Assessment and Consultation, Agency for Toxic Substances and Disease Registry, Public Health Service, Atlanta, GA 30345, USA. gulirsch@cdc.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 478
EP  - 487
VL  - 17
IS  - 5
SN  - 1559-0631, 1559-0631
KW  - Air Pollutants
KW  - 0
KW  - Particulate Matter
KW  - Carbon Dioxide
KW  - 142M471B3J
KW  - Nitrogen Dioxide
KW  - S7G510RUBH
KW  - Index Medicus
KW  - Age Factors
KW  - Nitrogen Dioxide -- toxicity
KW  - Humans
KW  - Linear Models
KW  - Infant, Newborn
KW  - Aged
KW  - Child
KW  - Models, Biological
KW  - Infant
KW  - Seasons
KW  - Adult
KW  - Idaho -- epidemiology
KW  - Middle Aged
KW  - Adolescent
KW  - Time Factors
KW  - Cities -- epidemiology
KW  - Carbon Dioxide -- toxicity
KW  - Particulate Matter -- toxicity
KW  - Lung Diseases -- etiology
KW  - Air Pollution -- adverse effects
KW  - Hospitalization -- statistics & numerical data
KW  - Air Pollutants -- toxicity
KW  - Heart Diseases -- etiology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Effect+of+particulate+matter+air+pollution+on+hospital+admissions+and+medical+visits+for+lung+and+heart+disease+in+two+southeast+Idaho+cities.&rft.au=Ulirsch%2C+Gregory+V%3BBall%2C+Louise+M%3BKaye%2C+Wendy%3BShy%2C+Carl+M%3BLee%2C+Carolyn+V%3BCrawford-Brown%2C+Douglas%3BSymons%2C+Michael%3BHolloway%2C+Tracey&rft.aulast=Ulirsch&rft.aufirst=Gregory&rft.date=2007-08-01&rft.volume=17&rft.issue=5&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=15590631&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-04
N1  - Date created - 2007-08-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma.
AN  - 68147812; 17684125
AB  - alpha-Methylacyl-CoA racemase (AMACR), an enzyme involved in oxidation of branched chain fatty acids and cholesterol metabolites, as well as ibuprofen metabolism, is overexpressed in colorectal adenomas and cancer. AMACR gene variants have been associated with hereditary prostate cancer, but no studies have evaluated their etiologic role in colorectal carcinogenesis.
          We conducted a case-control study of 725 advanced distal colorectal adenoma cases and 729 frequency-matched controls from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Seven AMACR polymorphisms were genotyped. Unconditional logistic regression models were used to evaluate the associations adjusting for age at randomization and gender. The 201L allele of S201L [TT versus CC: odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.15-2.62; TC versus CC: OR, 1.17; 95% CI, 0.93-1.49] and the 277E allele of K277E (GG versus AA: OR, 1.66; 95% CI, 1.03-2.68; GA versus AA: OR, 1.21; 95% CI, 0.96-1.53) were associated with increased risk of advanced distal colorectal adenoma (both P(trend) </= 0.02); the TGTGCG haplotype of six informative single nucleotide polymorphisms was also associated with increased risk (OR, 1.27; 95% CI, 1.03-1.55). Regular ibuprofen users who were homozygous for the variant allele at either M9V or D175G were at reduced risk for adenoma (both P(interaction) < 0.05).
          Our study identified variants in AMACR associated with advanced distal colorectal adenoma and pointed to potential interactions with ibuprofen use.
JF  - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
AU  - Daugherty, Sarah E
AU  - Platz, Elizabeth A
AU  - Shugart, Yin Yao
AU  - Fallin, M Daniele
AU  - Isaacs, William B
AU  - Chatterjee, Nilanjin
AU  - Welch, Robert
AU  - Huang, Wen-Yi
AU  - Hayes, Richard B
AD  - Divison of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, 6120 Executive Boulevard, EPS Rm 8113, Bethesda, MD 20892, USA. daughers@mail.nih.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 1536
EP  - 1542
VL  - 16
IS  - 8
SN  - 1055-9965, 1055-9965
KW  - Anti-Inflammatory Agents, Non-Steroidal
KW  - 0
KW  - Aspartic Acid
KW  - 30KYC7MIAI
KW  - Glutamic Acid
KW  - 3KX376GY7L
KW  - Serine
KW  - 452VLY9402
KW  - Methionine
KW  - AE28F7PNPL
KW  - Racemases and Epimerases
KW  - EC 5.1.-
KW  - alpha-methylacyl-CoA racemase
KW  - EC 5.1.99.4
KW  - Leucine
KW  - GMW67QNF9C
KW  - Valine
KW  - HG18B9YRS7
KW  - Lysine
KW  - K3Z4F929H6
KW  - Glycine
KW  - TE7660XO1C
KW  - Ibuprofen
KW  - WK2XYI10QM
KW  - Index Medicus
KW  - Aspartic Acid -- genetics
KW  - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use
KW  - Polymorphism, Genetic -- genetics
KW  - Humans
KW  - Leucine -- genetics
KW  - Aged
KW  - Valine -- genetics
KW  - Lysine -- genetics
KW  - Serine -- genetics
KW  - Glutamic Acid -- genetics
KW  - Genotype
KW  - Methionine -- genetics
KW  - Alleles
KW  - Glycine -- genetics
KW  - Haplotypes
KW  - Ibuprofen -- therapeutic use
KW  - Case-Control Studies
KW  - Middle Aged
KW  - Polymorphism, Single Nucleotide -- genetics
KW  - Male
KW  - Female
KW  - Rectal Neoplasms -- genetics
KW  - Racemases and Epimerases -- genetics
KW  - Colonic Neoplasms -- genetics
KW  - Adenoma -- enzymology
KW  - Rectal Neoplasms -- enzymology
KW  - Genetic Variation -- genetics
KW  - Adenoma -- genetics
KW  - Colonic Neoplasms -- enzymology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-11
N1  - Date created - 2007-08-08
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Role of nitric oxide in chick embryonic organogenesis and dysmorphogenesis.
AN  - 68143490; 17676596
AB  - Nitric oxide (NO), produced by the nitric oxide synthase family of enzymes, mediates multiple signaling functions, and when unchecked, NO causes pathological damage. Exposure of embryos to a variety of teratogens, including carbon monoxide (CO), has been shown to increase reactive intermediates, such as NO, and recent work showed that either the excess or absence of NO caused morphological defects. While endogenous NO is known to regulate many adult tissues, its role during embryonic organogenesis and/or in mediating responses to teratogen exposure has not been explored.
          We have examined here the presence of NO during normal chick embryonic organogenesis, and investigated the teratogenicity of NO through the application of sodium nitroprusside (SNP), which mimics NO overproduction, and NG-monomethyl-L-arginine (L-NMMA), which inhibits endogenous NOS activity. Topical treatment with SNP or L-NMMA for 18 h resulted in morphological defects, specifically in the neural tube and somites, which corresponded to sites of altered apoptosis. The location of NO was histochemically correlated with the observed morphological defects. Coadministration of SNP or L-NMMA with CO showed functional coregulation and interaction between NO and CO in chick embryonic development.
          Our results showed that regulation of NO is essential for normal axial development, that sites of altered NO expression correlate to those of altered apoptosis and dysmorphogenesis, and that CO coadministration resulted in a rectification of normal NO expression. Collectively, these results suggest that alteration in endogenous NO/CO signaling is responsible, at least in part, for the observed NO-induced teratogenesis. 2007 Wiley-Liss, Inc.
JF  - Birth defects research. Part A, Clinical and molecular teratology
AU  - Alexander, Peter G
AU  - Chau, Lillian
AU  - Tuan, Rocky S
AD  - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-8022, USA.
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 581
EP  - 594
VL  - 79
IS  - 8
SN  - 1542-0752, 1542-0752
KW  - Drug Combinations
KW  - 0
KW  - Enzyme Inhibitors
KW  - Teratogens
KW  - Nitroprusside
KW  - 169D1260KM
KW  - omega-N-Methylarginine
KW  - 27JT06E6GR
KW  - Nitric Oxide
KW  - 31C4KY9ESH
KW  - Carbon Monoxide
KW  - 7U1EE4V452
KW  - Nitric Oxide Synthase Type I
KW  - EC 1.14.13.39
KW  - Index Medicus
KW  - Animals
KW  - Somites -- drug effects
KW  - Chick Embryo
KW  - Enzyme Inhibitors -- toxicity
KW  - Somites -- metabolism
KW  - Somites -- pathology
KW  - Embryo Loss -- chemically induced
KW  - Nitric Oxide Synthase Type I -- metabolism
KW  - Embryo Loss -- pathology
KW  - Nitric Oxide Synthase Type I -- antagonists & inhibitors
KW  - Nitroprusside -- toxicity
KW  - Apoptosis -- drug effects
KW  - Carbon Monoxide -- toxicity
KW  - Teratogens -- toxicity
KW  - omega-N-Methylarginine -- toxicity
KW  - Organogenesis -- physiology
KW  - Organogenesis -- drug effects
KW  - Neural Tube Defects -- metabolism
KW  - Neural Tube Defects -- pathology
KW  - Neural Tube Defects -- chemically induced
KW  - Nitric Oxide -- metabolism
KW  - Embryonic Development -- drug effects
KW  - Embryonic Development -- physiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-02
N1  - Date created - 2007-08-09
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review.
AN  - 68128896; 17675030
AB  - Oxcarbazepine, a carbamazepine analog, was approved for use as an antiepileptic agent in the United States in 2000. A search of the United States Food and Drug Administration's Adverse Event Reporting System identified nine cases of oxcarbazepine-associated angioedema in pediatric patients aged 16 years and younger. We describe in detail the first U.S. case report, of a 4(1/2)-year-old boy who experienced angioedema during treatment with oxcarbazepine. The reporting rate for angioedema was calculated to be 9.8 cases per 1,000,000 pediatric patients. Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital.
JF  - Pediatric neurology
AU  - Knudsen, James F
AU  - Flowers, Charlene M
AU  - Kortepeter, Cindy
AU  - Awaad, Yasser
AD  - Office of Drug Evaluation I, Division of Neurology Products, Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. james.knudsen@fda.hhs.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 134
EP  - 137
VL  - 37
IS  - 2
SN  - 0887-8994, 0887-8994
KW  - Anticonvulsants
KW  - 0
KW  - Carbamazepine
KW  - 33CM23913M
KW  - oxcarbazepine
KW  - VZI5B1W380
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Male
KW  - Child, Preschool
KW  - Carbamazepine -- adverse effects
KW  - Carbamazepine -- analogs & derivatives
KW  - Anticonvulsants -- adverse effects
KW  - Epilepsy -- drug therapy
KW  - Angioedema -- chemically induced
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Niosh%3A+Nanotechnologies+Safety+and+Health+Initiatives&rft.au=Hoover%2C+Mark&rft.aulast=Hoover&rft.aufirst=Mark&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-26
N1  - Date created - 2007-08-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - When is it safe to manually lift a patient?
AN  - 68110502; 17667392
AB  - In 1994 the National Institute for Occupational Safety and Health (NIOSH) released the Revised NIOSH Lifting Equation-an ergonomics assessment tool that can be used to calculate the recommended weight limit for two-handed manual-lifting tasks. However, NIOSH excluded assessment of patient-handling tasks from the uses of the revised equation, arguing that such tasks involve too many variables. The equation in fact can be used to calculate a recommended weight limit for a limited range of patient-handling tasks in which the patient is cooperative and unlikely to move suddenly during the task. In general, the revised equation yields a recommended 35-lb. maximum weight limit for use in patient-handling tasks. When weight to be lifted exceeds this limit, assistive devices should be used.
JF  - The American journal of nursing
AU  - Waters, Thomas R
AD  - Division of Applied Research and Technology at National Institute for Occupational Safety and Health, Cincinnati, OH, USA. trw1@cdc.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 53
EP  - 8; quiz 59
VL  - 107
IS  - 8
SN  - 0002-936X, 0002-936X
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Nursing
KW  - United States
KW  - Human Engineering
KW  - Humans
KW  - Organizational Policy
KW  - Occupational Diseases -- prevention & control
KW  - Occupational Diseases -- etiology
KW  - National Institute for Occupational Safety and Health (U.S.)
KW  - Musculoskeletal Diseases -- etiology
KW  - Musculoskeletal Diseases -- prevention & control
KW  - Work Capacity Evaluation
KW  - Nursing Assessment
KW  - Biomechanical Phenomena
KW  - Nursing Staff -- organization & administration
KW  - Guidelines as Topic
KW  - Body Weight
KW  - Occupational Health
KW  - Risk Assessment -- organization & administration
KW  - Lifting -- adverse effects
KW  - Safety Management -- organization & administration
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-30
N1  - Date created - 2007-08-01
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Agency Ownership, Patient -2000nt Source, and Length of Service in Home Care, 19922000
AN  - 61752038; 200936472
AB  - Purpose: Little is known about whether an association exists between agency ownership and length of service among home care patients with different payment sources. This study investigated how for-profit and not-for-profit agencies responded to policy changes in the 1990s with respect to length of service. Design and Methods: We examined length of service among 37,364 home care patients using the 1992, 1994, 1996, 1998, and 2000 National Home and Hospice Care Surveys. We used Kaplan Meier methods and Cox regression models. Results: After we adjusted for patient and agency characteristics, our results revealed that agency ownership was not associated with length of service for patients with private insurance, Medicare, Medicaid, Medicare plus Medicaid, or Medicare plus private insurance. This finding was consistent from 1992 through 2000. Length of service among patients with Medicare decreased significantly from 1998 through 2000, but length of service among patients with Medicaid did not change significantly from 1992 through 2000. Implications: Agency ownership is not associated with patient length of service in home care. Regardless of the policy changes in the home care arena in the 1990s, for-profit and not-for-profit home health agencies behaved similarly with regard to length of service among patients within differently structured payment systems. Adapted from the source document.
JF  - The Gerontologist
AU  - Han, Beth
AU  - McAuley, William J
AU  - Remsburg, Robin E
AD  - Choke Cherry Road, Room 7-1010, Rockville, MD 20857. E-mail: beth.han@samhsa.hhs.gov
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 438
EP  - 446
PB  - Gerontological Society of America, Washington DC
VL  - 47
IS  - 4
SN  - 0016-9013, 0016-9013
KW  - Home care
KW  - Length of service in home care
KW  - Home health agency ownership
KW  - Medicare home health patients
KW  - Medicaid home health patients
KW  - Private health insurance patients in home care
KW  - Private Sector
KW  - Health Insurance
KW  - Social Agencies
KW  - Medicare
KW  - Medicaid
KW  - Nonprofit Organizations
KW  - Home Care
KW  - Health Care Costs
KW  - article
KW  - 2143: social problems and social welfare; social gerontology
KW  - 2045: sociology of health and medicine; sociology of medicine & health care
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LA  - English
DB  - Sociological Abstracts
N1  - Date revised - 2009-08-31
N1  - Last updated - 2016-09-28
N1  - CODEN - GRNTA3
N1  - SubjectsTermNotLitGenreText - Home Care; Private Sector; Health Care Costs; Social Agencies; Nonprofit Organizations; Health Insurance; Medicare; Medicaid
ER  - 



TY  - BOOK
T1  - The NIOSH Fire Fighter Fatality Investigation and Prevention Program
AN  - 58776100; 2008-150289
AB  - The United States currently depends on approximately 1.1 million fire fighters to protect its citizens and property from losses caused by fire. Of these fire fighters, approximately 313,000 are career and 823,000 are volunteers. The National Fire Protection Association (NFPA) and the U.S. Fire Administration estimate that on average, 100 fire fighters die in the line-of duty each year. In fiscal year 1998, Congress recognized the need for further efforts to address the continuing national problem of occupational fire fighter fatalities and funded NIOSH to implement a fire fighter safety initiative.
JF  - United States National Institute for Occupational Safety and Health (NIOSH), Aug 2007, 2 pp.
AU  - National Inst Occupational Safety and Health
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
EP  - 2p
PB  - United States National Institute for Occupational Safety and Health (NIOSH)
KW  - Social conditions and policy - Public safety and security
KW  - Science and technology policy - Biology and biotechnology
KW  - United States
KW  - Death
KW  - Safety measures
KW  - Firefighters
KW  - book
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Inst+Occupational+Safety+and+Health&rft.aulast=National+Inst+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2007-08-01&rft.volume=&rft.issue=&rft.spage=2p&rft.isbn=&rft.btitle=The+NIOSH+Fire+Fighter+Fatality+Investigation+and+Prevention+Program&rft.title=The+NIOSH+Fire+Fighter+Fatality+Investigation+and+Prevention+Program&rft.issn=&rft_id=info:doi/
L2  - http://www.cdc.gov/niosh/docs/2007-154/pdfs/2007-154.pdf
LA  - English
DB  - PAIS Index
N1  - Date revised - 2008-06-04
N1  - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007
N1  - SuppNotes - NIOSH Publication No. 2007-154
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - CARE Act Planning for Unmet Need
AN  - 58763025; 2008-95913
AB  - The Ryan White CARE Act, a safety net program first enacted in 1990, provides health and support services to people living with HIV (PLWH) in the U.S. through several Titles. Recipients of CARE Act funds-particularly metropolitan areas and States under Titles I and II, respectively-prioritize and allocate funds to cover unmet service needs. In the 2000 reauthorization of the CARE Act, Title I and II grantees were directed to determine unmet needs for services. This paper describes a process by which the HIV/AIDS Bureau of the Health Resources and Services Administration of the U.S. Department of Health and Human Services has assisted grantees in developing tools to make quantitative estimates of the unmet need for HIV primary care services. The process enables grantees to identify underserved populations and implement strategies to bring them into regular primary care. The Care System Assessment Demonstration Project supplements these tools. Adapted from the source document.
JF  - Journal of Health Care for the Poor and Underserved
AU  - Hopson, Deborah Parham
AU  - Morgan, Douglas H
AU  - Gray, Sonya Hunt
AU  - Conviser, Richard
AD  - HIV/AIDS Bureau, Health Resources and Services Administration, Department of Health and Human Services, Ryan White HIV/AIDS Programs
Y1  - 2007/08//
PY  - 2007
DA  - August 2007
SP  - 1
EP  - 7
PB  - John Hopkins University Press, Baltimore MD
VL  - 18
IS  - Supplement 3
SN  - 1049-2089, 1049-2089
KW  - Health conditions and policy - Diseases and disorders
KW  - Health conditions and policy - Health and health policy
KW  - Health conditions and policy - Medicine and health care
KW  - Law and ethics - Law and jurisprudence
KW  - CARE Act, HIV, unmet need.
KW  - United States
KW  - Human immunodeficiency virus
KW  - Medical service
KW  - Legislation
KW  - Public health
KW  - article
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=CARE+Act+Planning+for+Unmet+Need&rft.au=Hopson%2C+Deborah+Parham%3BMorgan%2C+Douglas+H%3BGray%2C+Sonya+Hunt%3BConviser%2C+Richard&rft.aulast=Dejager&rft.aufirst=Lowri&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/
LA  - English
DB  - PAIS Index
N1  - Date revised - 2008-01-14
N1  - Last updated - 2016-09-28
N1  - CODEN - JHCUEK
N1  - SubjectsTermNotLitGenreText - Human immunodeficiency virus; United States; Public health; Medical service; Legislation
ER  - 



TY  - JOUR
T1  - Latent variable models under misspecification: two-stage least squares (2SLS) and maximum likelihood(ML) estimators
AN  - 36855372; 3531385
AB  - This article compares maximum likelihood (ML) estimation to three variants of two-stage least squares (2SLS) estimation in structural equation models. The authors use models that are both correctly and incorrectly specified. Simulated data are used to assess bias, efficiency, and accuracy of hypothesis tests. Generally, 2SLS with reduced sets of instrumental variables performs similarly to ML when models are correctly specified. Under correct specification, both estimators have little bias except at the smallest sample sizes and are approximately equally efficient. As predicted, when models are incorrectly specified, 2SLS generally performs better, with less bias and more accurate hypothesis tests. Unless a researcher has tremendous confidence in the correctness of his or her model, these results suggest that a 2SLS estimator should be considered. Reprinted by permission of Sage Publications, Inc.
JF  - Sociological methods and research
AU  - Bollen, Kenneth A
AU  - Kirby, James B
AU  - Curran, Patrick J
AU  - Paxton, Pamela M
AU  - Chen, Feinian
AD  - University of North Carolina, Chapel Hill ; Agency for Healthcare Research and Quality, Rockville ; Ohio State University ; North Carolina State University, Raleigh
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 48
EP  - 86
VL  - 36
IS  - 1
SN  - 0049-1241, 0049-1241
KW  - Sociology
KW  - Comparative analysis
KW  - Sociological research
KW  - Research methods
KW  - Bias
KW  - Models
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Some+Applications+of+GC-MS%2FMS+and+LC-MS%2FMS+to+Analyze+Pesticides+and+Chemical+Contaminants+in+Foods&rft.au=Wong%2C+Jon+W%3BKrynitsky%2C+Alexander+J&rft.aulast=Wong&rft.aufirst=Jon&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/
LA  - English
DB  - International Bibliography of the Social Sciences (IBSS)
N1  - Date revised - 2013-06-12
N1  - Last updated - 2013-09-16
N1  - SubjectsTermNotLitGenreText - 8163; 2630 971; 1565 1362 2688 2449 10404; 12002 10902; 10919
DO  - http://dx.doi.org/10.1177/0049124107301947
ER  - 



TY  - JOUR
T1  - Serotonergic influences on life-history outcomes in free-ranging male rhesus macaques
AN  - 36846510; 3526061
AB  - Several studies have demonstrated that nonhuman primate males with low cerebrospinal fluid (CSF) levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) exhibit antisocial behavior patterns. Included in these deleterious patterns are impulse control deficits associated with violence and premature death. No studies to date have longitudinally studied the long-term outcome of young subjects with low CSF 5-HIAA concentrations as they mature into adults. In this study we examined longitudinal relations among serotonergic and dopaminergic functioning, as reflected in CSF metabolite concentrations, aggression, age at emigration, dominance rank, and mortality in free-ranging rhesus macaque (Macaca mulatta) males. Our results indicate long-term consistency of individual differences in levels of 5-HIAA in CSF in the subject population from the juvenile period of development through adulthood. We found a significant negative correlation between 5-HIAA concentrations measured in juveniles and rates of high-intensity aggression in the same animals as adults. Further, CSF 5-HIAA concentrations were lower in juveniles that died than in animals that survived. For the young animals that migrated there was a positive correlation between CSF 5-HIAA concentration and age at emigration, whereas for the animals that remained in their troop until later in sexual maturity there was a negative correlation between CSF 5-HIAA concentration and age of emigration. After animals emigrated to a new troop, social dominance rank in the new troop was positively correlated with early family social dominance rank, but inversely correlated with juvenile CSF 5-HIAA concentrations. Taken together, our findings suggest that males with low central serotonin levels early in life delay migration and show high levels of violence and premature death, but the males that survive achieve high rank. These findings indicate that longitudinal measures of serotonergic and dopaminergic functioning are predictive of major life-history outcomes in nonhuman primate males. Low concentrations of CSF 5-HIAA are associated with negative life-history patterns characterized by social instability and excessive aggression, and positive life-history patterns characterized by higher dominance rank. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com
JF  - American journal of primatology
AU  - Howell, Sue
AU  - Westergaard, Greg
AU  - Hoos, Beth
AU  - Chavanne, Tara J
AU  - Shoaf, Susan E
AU  - Cleveland, Allison
AU  - Snoy, Philip J
AU  - Suomi, Stephen J
AU  - Higley, J Dee
AD  - Division of Research and Development, Alpha Genesis, Inc., Yemassee ; Division of Research and Development, Alpha Genesis, Inc., Yemasee ; National Institute on Alcohol Abuse and Alcoholism ; Center for Biologics Evaluation and Research, Rockville ; National Institute of Child Health and Human Development
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 851
EP  - 865
VL  - 69
IS  - 8
SN  - 0275-2565, 0275-2565
KW  - Anthropology
KW  - Macaques
KW  - Longitudinal studies
KW  - Mortality
KW  - Life history
KW  - Physical anthropology
KW  - Primatology
KW  - Primate behaviour
KW  - Migration
KW  - Hormones
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LA  - English
DB  - International Bibliography of the Social Sciences (IBSS)
N1  - Date revised - 2013-06-12
N1  - Last updated - 2013-09-16
N1  - SubjectsTermNotLitGenreText - 9507 1077; 5983 9524 1615 8573 11325; 7541 7537 971; 8040; 7398 5889; 8291 3409 6306; 10144 10148 10149 1542 11325; 10149
DO  - http://dx.doi.org/10.1002/ajp.20369
ER  - 



TY  - JOUR
T1  - Agar Dilution and Disk Diffusion Susceptibility Testing of Campylobacter spp.
AN  - 21125382; 7558245
JF  - Journal of Clinical Microbiology
AU  - Fritsche, Thomas R
AU  - McDermott, Patrick F
AU  - Shryock, Thomas R
AU  - Walker, Robert D
AD  - JMI Laboratories , 345 Beaver Kreek Centre, Suite A , North Liberty, Iowa 52317. U.S. Food and Drug Administration , Center for Veterinary Medicine , Laurel, Maryland 20708. Elanco Animal Health , Greenfield, Indiana 46140. Mesa State College , Grand Junction, Colorado 81501
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 2758
EP  - 2759
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 45
IS  - 8
SN  - 0095-1137, 0095-1137
KW  - Microbiology Abstracts B: Bacteriology
KW  - Agar
KW  - Campylobacter
KW  - Diffusion
KW  - J 02340:Antibiotics & Antimicrobials
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-01-01
N1  - Last updated - 2015-03-31
N1  - SubjectsTermNotLitGenreText - Agar; Diffusion; Campylobacter
ER  - 



TY  - JOUR
T1  - A prospective study of polymorphisms of DNA repair genes XRCC1, XPD23 and APE/ref-1 and risk of stroke in Linxian, China
AN  - 20756886; 7531528
AB  - BACKGROUND: Stroke is the leading cause of death in Linxian, China. Although there is evidence of DNA damage in experimental stroke, no data exist on DNA repair and stroke in human populations. Aim: To assess the risk of stroke conferred by polymorphisms in the DNA repair genes, XRCC1, XPD23 and APE/ref-1 in a cohort of individuals originally assembled as subjects in two cancer prevention trials in Linxian, China. METHODS: The subjects for this prospective study were sampled from a cohort of 4005 eligible subjects who were alive and cancer free in 1991 and had blood samples available for DNA extraction. Using real-time Taqman analyses, all incident cases of stroke (n = 118) that developed from May 1996, and an age- and a sex-stratified random sample (n = 454) drawn from all eligible subjects were genotyped. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% CIs. RESULTS: No association was observed between polymorphisms in APE/ref-1 codon 148 and XRCC1*6 codon 194, and stroke. Polymorphisms in XRCC1*10 codon 399 were associated with a significantly reduced risk of stroke (RR 0.59, 95% CI 0.36 to 0.96, p = 0.033), whereas XPD23 codon 312 was associated with a significantly increased risk of stroke (RR 2.18, 95% CI 1.14 to 4.17, p = 0.010). CONCLUSIONS: Polymorphisms in DNA repair genes may be important in the aetiology of stroke. These data should stimulate research on DNA damage and repair in stroke.
JF  - Journal of Epidemiology and Community Health
AU  - Mahabir, Somdat
AU  - Abnet, Christian C
AU  - Qiao, You-Lin
AU  - Ratnasinghe, Luke D
AU  - Dawsey, Sanford M
AU  - Dong, Zhi-Wei
AU  - Taylor, Philip R
AU  - Mark, Steven D
AD  - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. Department of Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. Center for Structural Genomics, NCTR, Food and Drug Administration, Jefferson and Arkansas Cancer Research Center, UAMS, Little Rock, Arkansas, USA. Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 737
EP  - 741
PB  - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/]
VL  - 61
IS  - 8
SN  - 0143-005X, 0143-005X
KW  - stroke
KW  - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts
KW  - Risk assessment
KW  - Mortality
KW  - Gene polymorphism
KW  - Stroke
KW  - X chromosome
KW  - XRCC1 protein
KW  - DNA repair
KW  - Cancer
KW  - Models
KW  - risk reduction
KW  - DNA damage
KW  - DNA
KW  - prevention
KW  - Codons
KW  - China, People's Rep.
KW  - human populations
KW  - G 07880:Human Genetics
KW  - N 14820:DNA Metabolism & Structure
KW  - R2 23060:Medical and environmental health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-08-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Risk assessment; DNA damage; Gene polymorphism; X chromosome; Stroke; Codons; XRCC1 protein; DNA repair; Cancer; Models; Mortality; risk reduction; prevention; DNA; human populations; China, People's Rep.
ER  - 



TY  - JOUR
T1  - Polymorphisms in Apoptosis and Cell Cycle Control Genes and Risk of Brain Tumors in Adults
AN  - 20720908; 7555870
AB  - Despite the potential importance of the cell cycle and apoptosis pathways in brain tumor etiology, little has been published regarding brain tumor risk associated with common gene variants in these pathways. Using data from a hospital-based case-control study conducted by the National Cancer Institute between 1994 and 1998, we evaluated risk of glioma (n = 388), meningioma (n = 162), and acoustic neuroma (n = 73) with respect to 12 single nucleotide polymorphisms from 10 genes involved in apoptosis and cell cycle control: CASP8, CCND1, CCNH, CDKN1A, CDKN2A, CHEK1, CHEK2, MDM2, PTEN, and TP53. We observed significantly decreased risk of meningioma with the CASP8 Ex14-271A>T variant [odds ratio (OR) sub(AT), 0.8; 95% confidence interval (95% CI), 0.5-1.2; OR sub(AA), 0.5; 95% CI, 0.3-0.9; P sub(trend) = 0.03] and increased risk of meningioma with the CASP8 Ex13+51G>C variant (OR sub(GC), 1.4; 95% CI, 0.9-2.1; OR sub(CC), 3.6; 95% CI, 1.0-13.1; P sub(trend) = 0.04). The CT haplotype of the two CASP8 polymorphisms was associated with significantly increased risk of meningioma (OR, 1.7; 95% CI, 1.1-2.6), but was not associated with risk of glioma or acoustic neuroma. The CCND1 Ex4-1G>A variant was associated with increased risk for glioma, and the Ex8+49T>C variant of CCNH was associated with increased risk of glioma and acoustic neuroma. The MDM2 Ex12+162A>G variant was associated with significantly reduced risk of glioma. Our results suggest that common variants in the CASP8, CCND1, CCNH, and MDM2 genes may influence brain tumor risk. Future research in this area should include more detailed coverage of genes in the apoptosis/cell cycle control pathways. (Cancer Epidemiol Biomarkers Prev 2007; 16(8):1655-61)
JF  - Cancer Epidemiology, Biomarkers & Prevention
AU  - Rajaraman, Preetha
AU  - Wang, Sophia S
AU  - Rothman, Nathaniel
AU  - Brown, Merideth M
AU  - Black, Peter M
AU  - Fine, Howard A
AU  - Loeffler, Jay S
AU  - Selker, Robert G
AU  - Shapiro, William R
AU  - Chanock, Stephen J
AU  - Inskip, Peter D
AD  - Division of Cancer Epidemiology and Genetics, Core Genotyping Facility, Neuro-oncology Branch, and Pediatric Oncology Branch, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 1655
EP  - 1661
PB  - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/]
VL  - 16
IS  - 8
SN  - 1055-9965, 1055-9965
KW  - Genetics Abstracts; Risk Abstracts; CSA Neurosciences Abstracts
KW  - Apoptosis
KW  - Gene polymorphism
KW  - Cell cycle
KW  - PTEN protein
KW  - Neoplasia
KW  - glioma
KW  - risk reduction
KW  - Haplotypes
KW  - prevention
KW  - Glioma
KW  - brain tumors
KW  - Bioindicators
KW  - MDM2 protein
KW  - Etiology
KW  - Data processing
KW  - haplotypes
KW  - biomarkers
KW  - Cancer
KW  - p53 protein
KW  - Brain tumors
KW  - Single-nucleotide polymorphism
KW  - France, Aquitaine, Oraas
KW  - meningioma
KW  - N3 11023:Neurogenetics
KW  - R2 23060:Medical and environmental health
KW  - G 07730:Development & Cell Cycle
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Polymorphisms+in+Apoptosis+and+Cell+Cycle+Control+Genes+and+Risk+of+Brain+Tumors+in+Adults&rft.au=Rajaraman%2C+Preetha%3BWang%2C+Sophia+S%3BRothman%2C+Nathaniel%3BBrown%2C+Merideth+M%3BBlack%2C+Peter+M%3BFine%2C+Howard+A%3BLoeffler%2C+Jay+S%3BSelker%2C+Robert+G%3BShapiro%2C+William+R%3BChanock%2C+Stephen+J%3BInskip%2C+Peter+D&rft.aulast=Rajaraman&rft.aufirst=Preetha&rft.date=2007-08-01&rft.volume=16&rft.issue=8&rft.spage=1655&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - MDM2 protein; Etiology; Data processing; Apoptosis; Gene polymorphism; Cell cycle; PTEN protein; biomarkers; Neoplasia; p53 protein; Brain tumors; Haplotypes; Single-nucleotide polymorphism; Glioma; meningioma; Bioindicators; risk reduction; glioma; prevention; haplotypes; brain tumors; Cancer; France, Aquitaine, Oraas
ER  - 



TY  - JOUR
T1  - Phage passage after extended processing in small-virus-retentive filters
AN  - 20700483; 7566324
AB  - Retention of a two small phages (X-174 and pp7) by direct-flow small-virus-retentive filters [Viresolve NFP (normal-flow parvovims), Virosart CPV (canine parvo-virus), Ultipor DV20 and Planova 20N] was studied using a commercial-process fluid. Phage passage occurred in each filter type, particularly when overloaded with phage. Clearances of pp7 and X-174 were similar for any given filter brand, arguing that the two phages are equivalent for testing small-virus-retentive filters. The patterns of flux under constant pressure and instantaneous LRV (log reduction value) in relationship to cumulative phage load differed between brands, consistent with the current industry understanding that each brand possesses specific performance attributes. Phages are a powerful and universal tool for evaluating filter performance. Validation of filter performance with phages such as pp7 or X-174 as models for small mammalian viruses represents an attractive alternative to the current practice.
JF  - Biotechnology and Applied Biochemistry
AU  - Lute, S
AU  - Bailey, M
AU  - Combs, J
AU  - Sukumar, M
AU  - Brorson, K
AD  - Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA, kurt.brorson@fda.hhs.gov
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 141
EP  - 151
PB  - Portland Press Ltd., 59 Portland Place London W1N 3AJ UK, [mailto:sales@portlandpress.co.uk]
VL  - 47
IS  - 3-4
SN  - 0885-4513, 0885-4513
KW  - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts
KW  - Phages
KW  - Filters
KW  - Training
KW  - Pressure
KW  - Models
KW  - W 30925:Genetic Engineering
KW  - V 22410:Animal Diseases
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Filters; Phages; Training; Pressure; Models
DO  - http://dx.doi.org/10.1042/BA20060254
ER  - 



TY  - JOUR
T1  - ATSDR evaluation of potential for human exposure to zinc
AN  - 20564547; 8071484
AB  - As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxico-logical profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the toxicological profile for zinc. The primary purpose of this article is to provide interested individuals with environmental information on zinc that includes production data, environmental fate, potential for human exposure, analytical methods and a listing of regulations and advisories.
JF  - Toxicology and Industrial Health
AU  - Roney, N
AU  - Osier, M
AU  - Paikoff, S J
AU  - Smith, C V
AU  - Williams, M
AU  - De Rosa, CT
AD  - Agency for Toxic Substances and Disease Registry (ATSDR), DTEM, U.S. Department of Health and Human Services, 1600 Clifton Road, Mailstop F32, Atlanta, GA 30333. USA, nroney@cdc.gov
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 247
EP  - 308
VL  - 23
IS  - 5-6
SN  - 0748-2337, 0748-2337
KW  - Pollution Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts
KW  - Chemicals
KW  - Federal regulations
KW  - Pollution clean-up
KW  - Superfund
KW  - CERCLA
KW  - Liability
KW  - Environmental protection
KW  - Public health
KW  - EPA
KW  - Environmental information
KW  - Zinc
KW  - Environmental restoration
KW  - Legislation
KW  - Hazardous wastes
KW  - P 9000:ENVIRONMENTAL ACTION
KW  - H 14000:Toxicology
KW  - X 24360:Metals
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-03-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Zinc; Public health; Chemicals; Federal regulations; Pollution clean-up; Superfund; CERCLA; Liability; Environmental protection; EPA; Environmental information; Environmental restoration; Hazardous wastes; Legislation
DO  - http://dx.doi.org/10.1177/0748233707083761
ER  - 



TY  - JOUR
T1  - A field investigation of manual forces associated with trigger and push to start electric screwdrivers
AN  - 20477994; 7961047
AB  - This study investigated manual forces associated with trigger start (TS) and push to start (PTS) activation in-line electric screwdriver designs. The vertically directed axial screwdriver force transmitted with the driver to the fastener and the grip/finger forces on the driver handle were measured from 13 employees in an electronics assembly manufacturing facility. The PTS driver was associated with significantly ( p < .01) higher axial force than the TS driver at two of the four workstations, where the difference was as high as a 184% increase (36.5 vs. 103.8 N). Total finger force on the screwdriver handle was also higher for the PTS screwdriver ( p < .01). The PTS screwdriver may reduce instances of fastener head damage (cam out) by requiring a minimum level of axial force to ensure better contact between the screwdriver bit and the fastener. However, this appears to come at the expense of greater manual forces exerted by the operator.
JF  - Human Factors and Ergonomics in Manufacturing
AU  - Lowe, Brian D
AU  - Kong, Yong-Ku
AU  - Krieg, Edward
AU  - Wurzelbacher, Steven
AU  - Lee, Soo-Jin
AD  - National Institute for Occupational Safety and Health, Cincinnati, OH, USA, blowe@cdc.gov
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 367
EP  - 382
PB  - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/]
VL  - 17
IS  - 4
SN  - 1090-8471, 1090-8471
KW  - Health & Safety Science Abstracts
KW  - Manufacturing industry
KW  - Human factors
KW  - Ergonomics
KW  - hand tools
KW  - H 10000:Ergonomics/Human Factors
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Impact+of+Systems+Toxicology+on+the+3Rs&rft.au=Fuscoe%2C+James+C&rft.aulast=Fuscoe&rft.aufirst=James&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-02-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Manufacturing industry; Human factors; hand tools; Ergonomics
DO  - http://dx.doi.org/10.1002/hfm.20079
ER  - 



TY  - JOUR
T1  - A synthetic polypeptide based on human E-cadherin inhibits invasion of human intestinal and liver cell lines by Listeria monocytogenes
AN  - 20468858; 7647626
AB  - Internalin A is a surface protein of the facultative intracellular pathogen Listeria monocytogenes that interacts with the human host cell protein E-cadherin to facilitate invasion of epithelial cells. A single amino acid substitution at position 16 in mouse E-cadherin prevents this interaction. Synthetic polypeptides of 30 aa encompassing position 16 of human and mouse E-cadherin were tested for their ability to inhibit in vitro invasion of Caco-2, HepG2 and TIB73 cell lines by L monocytogenes. Only the human-derived peptide was capable of inhibiting invasion in the human-origin Caco-2 and HepG2 cell lines. These findings demonstrate that small polypeptides can inhibit invasion of biologically relevant cell types by L monocytogenes in vitro and may be potentially useful as therapeutic agents in vivo.
JF  - Journal of Medical Microbiology
AU  - Sahu, S C
AU  - Gaines, D W
AU  - Williams, K M
AU  - Raybourne, R B
AD  - Immunobiology Branch, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD 20708, USA, richard.raybourne@fda.hhs.gov
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 1011
EP  - 1016
VL  - 56
IS  - 8
SN  - 0022-2615, 0022-2615
KW  - Microbiology Abstracts B: Bacteriology
KW  - Listeria monocytogenes
KW  - Epithelial cells
KW  - internalin
KW  - Amino acid substitution
KW  - Hepatocytes
KW  - E- double prime Cadherin
KW  - Intestine
KW  - Pathogens
KW  - J 02340:Antibiotics & Antimicrobials
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Epithelial cells; Amino acid substitution; internalin; Hepatocytes; E- double prime Cadherin; Intestine; Pathogens; Listeria monocytogenes
DO  - http://dx.doi.org/10.1099/jmm.0.47194-0
ER  - 



TY  - JOUR
T1  - A Community Outbreak of Campylobacter Jejuni Infection from a Chlorinated Public Water Supply
AN  - 20364145; 7663155
AB  - An outbreak of Campylobacter jejuni infection occurred in a South Wales Valleys housing estate. Illness in estate residents was associated with tap water consumption [population attributable risk (PAR) 50%, relative risk (RR) 2.53, 95% confidence interval (CI) 1.9-3.37] and residence in the upper estate (PAR 49%, RR 2.44, 95% CI 1.83-3.24). Amongst upper estate residents, rates of diarrhoeal illness increased with rates of water consumption (OR 18, 95% CI 3.5-92.4 for heaviest consumers, X sub(2) trend P<0.0001). The upper estate received mains water via a covered holding reservoir. A crack in the wall of the holding reservoir was identified. Contamination with surface water from nearby pasture land was the likely cause of this outbreak. Service reservoirs are common in rural communities and need regular maintenance and inspection. The role of water in sporadic cases of campylobacter enteritis may be underestimated. (Accepted December 16 2006) (Online publication February 09 2007)
JF  - Epidemiology and Infection
AU  - Richardson, G
AU  - Thomas, DRh
AU  - Smith, RMM
AU  - Nehaul, L
AU  - Ribeiro, C D
AU  - Brown, A G
AU  - Salmon, R L
AD  - National Public Health Service, Communicable Disease Surveillance Centre, Cardiff, UK
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 1151
EP  - 1158
PB  - Cambridge University Press, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org]
VL  - 135
IS  - 7
SN  - 0950-2688, 0950-2688
KW  - Risk Abstracts; Aqualine Abstracts; Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Pollution Abstracts
KW  - Risk assessment
KW  - Housing
KW  - Contamination
KW  - Surface water
KW  - Surface Water
KW  - inspection
KW  - Infection
KW  - Pasture
KW  - Water supplies
KW  - Drinking Water
KW  - Campylobacter jejuni
KW  - Water-borne diseases
KW  - infection
KW  - Consumers
KW  - Reservoirs
KW  - water use
KW  - British Isles, Wales, South Wales
KW  - valleys
KW  - Enteritis
KW  - Publications
KW  - outbreaks
KW  - Maintenance
KW  - Risk
KW  - Inspection
KW  - Drinking water
KW  - H 12000:Epidemiology and Public Health
KW  - AQ 00005:Underground Services and Water Use
KW  - J 02400:Human Diseases
KW  - R2 23060:Medical and environmental health
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=A+Community+Outbreak+of+Campylobacter+Jejuni+Infection+from+a+Chlorinated+Public+Water+Supply&rft.au=Richardson%2C+G%3BThomas%2C+DRh%3BSmith%2C+RMM%3BNehaul%2C+L%3BRibeiro%2C+C+D%3BBrown%2C+A+G%3BSalmon%2C+R+L&rft.aulast=Richardson&rft.aufirst=G&rft.date=2007-08-01&rft.volume=135&rft.issue=7&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268807007960
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Risk assessment; Contamination; Housing; Surface water; Enteritis; Consumers; Infection; Water supplies; Pasture; water use; valleys; infection; Water-borne diseases; outbreaks; Drinking water; inspection; Maintenance; Risk; Drinking Water; Surface Water; Publications; Inspection; Reservoirs; Campylobacter jejuni; British Isles, Wales, South Wales
DO  - http://dx.doi.org/10.1017/S0950268807007960
ER  - 



TY  - JOUR
T1  - Estimation of sound pressure level exposures from sound power level measurements of powered hand-tools
AN  - 20329500; 7646439
AB  - As part of a long-term goal to reduce noise-induced hearing loss in the construction industry, the National Institute for Occupational Safety and Health (NIOSH) estimated the A-weighted sound pressure level at the operator's ear (L sub(pA,est)) from the A-weighted sound power (L sub(wa)) measurements of 118 various model powered hand tools using the diffuse-field point source model Eyring theory. L sub(pA,est) from the model are compared to sound pressure measurements (L sub(pA,meas)) acquired from a microphone located in the nominal hearing zone of a simulated powered hand tool operator. This paper provides a basis for the direct substitution of L sub(WA) for L sub(pA,meas) and a comparison of L sub(pA,est), to L sub(pA,meas). The magnitude of L sub(WA) is found to be a reasonable predictor of the magnitude of sound pressure level exposure, or L sub(pA,meas), that a powered hand tool operator might experience across a variety of acoustical environments. As such, L sub(WA) can be used directly to select appropriate hearing protection and estimate worker' noise exposure. L sub(WA) can be measured for all power tools with appropriate loading conditions; however, measuring the sound pressure levels for all combinations of powered hand tools and acoustical environments in the construction industry is not feasible. Purchasers and users of those tools deserve a viable method of estimating noise exposure.
JF  - Noise Control Engineering Journal
AU  - Hayden, C S
AU  - Zechmann, EL
AD  - NIOSH, 4676 Columbia Parkway C27, Cincinnati OH 45226, USA, CHayden@cdc.gov
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 379
EP  - 389
VL  - 55
IS  - 4
SN  - 0736-2501, 0736-2501
KW  - Pollution Abstracts; Health & Safety Science Abstracts
KW  - Noise levels
KW  - Hearing loss
KW  - hand tools
KW  - Construction industry
KW  - Occupational exposure
KW  - Sound pressure
KW  - P 7000:NOISE
KW  - H 1000:Occupational Safety and Health
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+Control+Engineering+Journal&rft.atitle=Estimation+of+sound+pressure+level+exposures+from+sound+power+level+measurements+of+powered+hand-tools&rft.au=Hayden%2C+C+S%3BZechmann%2C+EL&rft.aulast=Hayden&rft.aufirst=C&rft.date=2007-08-01&rft.volume=55&rft.issue=4&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Noise+Control+Engineering+Journal&rft.issn=07362501&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Noise levels; Hearing loss; Occupational exposure; Construction industry; hand tools; Sound pressure
ER  - 



TY  - JOUR
T1  - Thrombocytopenia: Case definition and guidelines for collection, analysis, and presentation of immunization safety data
AN  - 20307993; 7640909
AB  - Disclaimer: The findings, opinions, and assertions contained in this consensus document are those of the individual scientific professional members of the Working Group. They do not necessarily represent the official positions of each participant's organization (e.g., government, university, or corporation). Specifically, the findings and conclusions in this paper are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention or the Food and Drug Administration.Corresponding author at: University Children's Hospital, Basel, Switzerland. Tel.: +41 61 6856565.1Currently employed by Eli Lilly and Company, Indianapolis, IN, USA.2Brighton Collaboration homepage: http://www.brightoncollaboration.org.
JF  - Vaccine
AU  - Wise, Robert P
AU  - Bonhoeffer, Jan
AU  - Beeler, Judy
AU  - Donato, Hugo
AU  - Downie, Peter
AU  - Matthews, Dana
AU  - Pool, Vitali
AU  - Riise-Bergsaker, Marianne
AU  - Tapiainen, Terhi
AU  - Varricchio, Frederick
AD  - Food and Drug Administration, Rockville, MD, USA, secretariat@brightoncollaboration.org
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 5717
EP  - 5724
PB  - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl]
VL  - 25
IS  - 31
SN  - 0264-410X, 0264-410X
KW  - thrombocytopenia
KW  - Health & Safety Science Abstracts; Immunology Abstracts
KW  - Thrombocytopenia
KW  - Adverse event
KW  - Immunization
KW  - Guidelines
KW  - Case definition
KW  - vaccines
KW  - Food
KW  - Disease control
KW  - disease control
KW  - Children
KW  - immunization
KW  - guidelines
KW  - prevention
KW  - Drugs
KW  - Hospitals
KW  - F 06905:Vaccines
KW  - H 4000:Food and Drugs
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Thrombocytopenia; Food; Disease control; Children; Drugs; Immunization; Hospitals; immunization; vaccines; guidelines; prevention; disease control
DO  - http://dx.doi.org/10.1016/j.vaccine.2007.02.067
ER  - 



TY  - JOUR
T1  - Influence of Mycobacterium avium subsp. paratuberculosis on Colitis Development and Specific Immune Responses during Disease
AN  - 20303548; 7530462
AB  - The granulomatous and intramural inflammation observed in cases of inflammatory bowel diseases (IBD) and veterinary Johne's disease suggests that Mycobacterium avium subsp. paratuberculosis is a causative agent. However, an incomplete understanding of the immunological steps responsible for the pathologies of IBD makes this conclusion uncertain. Sera from interleukin-10-deficient (IL-10 super(-/-)) mice with spontaneous colitis displayed significantly higher M. avium subsp. paratuberculosis-specific immunoglobulin G2a antibody responses than did sera from similar mice without disease. Pathogen-free IL-10 super(-/-) mice received control vehicle or the vehicle containing heat-killed or live M. avium subsp. paratuberculosis. Mucosal CD4 super(+) T cells from the mice that developed colitis proliferated and secreted higher levels of gamma interferon and tumor necrosis factor alpha after ex vivo stimulation with a V{szligbeta}11 super(+) T-cell receptor-restricted peptide from the MPT59 antigen (Ag85B) than those secreted from cells from mice before the onset of colitis. The data from this study provide important information regarding the mechanisms of colitis in IL-10 super(-/-) mice, which are driven in part by Ag85B-specific T cells. The data suggest a plausible mechanism of Ag-specific T-cell responses in colitis driven by potent Ags conserved in Mycobacterium species.
JF  - Infection and Immunity
AU  - Singh, Udai P
AU  - Singh, Shailesh
AU  - Singh, Rajesh
AU  - Karls, Russell K
AU  - Quinn, Frederick D
AU  - Potter, Morris E
AU  - Lillard, James WJr
AD  - Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia. Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky. Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia. Center for Food Safety and Applied Nutrition, Food and Drug Administration, Atlanta, Georgia
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 3722
EP  - 3728
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 75
IS  - 8
SN  - 0019-9567, 0019-9567
KW  - Immunology Abstracts; Microbiology Abstracts B: Bacteriology
KW  - gamma -Interferon
KW  - CD4 antigen
KW  - Mycobacterium avium
KW  - Inflammatory bowel diseases
KW  - Paratuberculosis
KW  - Mucosa
KW  - Lymphocytes T
KW  - Immunoglobulin G
KW  - Tumor necrosis factor- alpha
KW  - Colitis
KW  - J 02350:Immunology
KW  - F 06910:Microorganisms & Parasites
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-08-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - gamma -Interferon; CD4 antigen; Inflammatory bowel diseases; Mucosa; Paratuberculosis; Immunoglobulin G; Lymphocytes T; Tumor necrosis factor- alpha; Colitis; Mycobacterium avium
ER  - 



TY  - JOUR
T1  - Recombinant human parainfluenza virus type 2 vaccine candidates containing a 3' genomic promoter mutation and L polymerase mutations are attenuated and protective in non-human primates
AN  - 20302787; 7640983
AB  - Previously, we identified several attenuating mutations in the L polymerase protein of human parainfluenza virus type 2 (HPIV2) and genetically stabilized those mutations using reverse genetics [Nolan SM, Surman S, Amaro-Carambot E, Collins PL, Murphy BR, Skiadopoulos MH. Live-attenuated intranasal parainfluenza virus type 2 vaccine candidates developed by reverse genetics containing L polymerase protein mutations imported from heterologous paramyxoviruses. Vaccine 2005; 39(23):4765-74]. Here we describe the discovery of an attenuating mutation at nucleotide 15 (15T->C) in the 3' genomic promoter that was also present in the previously characterized mutants. We evaluated the properties of this promoter mutation alone and in various combinations with the L polymerase mutations. Amino acid substitutions at L protein positions 460 (460A or 460P) or 948 (948L), or deletion of amino acids 1724 and 1725 ( Delta 1724), each conferred a temperature sensitivity (ts) phenotype whereas the 15T->C mutation did not. The 460A and 948L mutations each contributed to restricted replication in the lower respiratory tract of African green monkeys, but the Delta 1724 mutation increased attenuation only in certain combinations with other mutations. We constructed two highly attenuated viruses, rV94(15C)/460A/948L and rV94(15C)/948L/ Delta 1724, that were immunogenic and protective against challenge with wild-type HPIV2 in African green monkeys and, therefore, appear to be suitable for evaluation in humans.
JF  - Vaccine
AU  - Nolan, Sheila M
AU  - Skiadopoulos, Mario H
AU  - Bradley, Konrad
AU  - Kim, Olivia S
AU  - Bier, Stacia
AU  - Amaro-Carambot, Emerito
AU  - Surman, Sonja R
AU  - Davis, Stephanie
AU  - Claire, Marisa St
AU  - Elkins, Randy
AU  - Collins, Peter L
AU  - Murphy, Brian R
AU  - Schaap-Nutt, Anne
AD  - Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, schaapa@niaid.nih.gov
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 6409
EP  - 6422
PB  - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl]
VL  - 25
IS  - 34
SN  - 0264-410X, 0264-410X
KW  - Primates
KW  - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts
KW  - Human parainfluenza virus
KW  - Live attenuated vaccine candidates
KW  - Non-human primate study
KW  - Temperature effects
KW  - double prime L protein
KW  - Amino acid substitution
KW  - Replication
KW  - Nucleotides
KW  - Parainfluenza virus
KW  - Parainfluenza
KW  - Promoters
KW  - Gene deletion
KW  - Immunogenicity
KW  - genomics
KW  - Vaccines
KW  - Mutation
KW  - Respiratory tract
KW  - V 22350:Immunology
KW  - F 06905:Vaccines
KW  - W 30915:Pharmaceuticals & Vaccines
KW  - G 07780:Fungi
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Temperature effects; double prime L protein; Amino acid substitution; Replication; Nucleotides; Parainfluenza; Promoters; Gene deletion; Immunogenicity; Vaccines; genomics; Mutation; Respiratory tract; Primates; Parainfluenza virus
DO  - http://dx.doi.org/10.1016/j.vaccine.2007.06.028
ER  - 



TY  - JOUR
T1  - Core-linked LPS expression of Shigella dysenteriae serotype 1 O-antigen in live Salmonella Typhi vaccine vector Ty21a: Preclinical evidence of immunogenicity and protection
AN  - 20301772; 7640953
AB  - Shigella dysenteriae serotype 1 (S. dysenteriae 1) causes severe shigellosis that is typically associated with high mortality. Antibodies against Shigella serotype-specific O-polysaccharide (O-Ps) have been shown to be host protective. In this study, the rfb locus and the rfp gene with their cognate promoter regions were PCR-amplified from S. dysenteriae 1, cloned, and sequenced. Deletion analysis showed that eight rfb ORFs plus rfp are necessary for biosynthesis of this O-Ps. A tandemly-linked rfb-rfp gene cassette was cloned into low copy plasmid pGB2 to create pSd1. Avirulent Salmonella enterica serovar Typhi (S. Typhi) Ty21a harboring pSd1 synthesized S. Typhi 9, 12 LPS as well as typical core-linked S. dysenteriae 1 LPS. Animal immunization studies showed that Ty21a (pSd1) induces protective immunity against high stringency challenge with virulent S. dysenteriae 1 strain 1617. These data further demonstrate the utility of S. Typhi Ty21a as a live, bacterial vaccine delivery system for heterologous O-antigens, supporting the promise of a bifunctional oral vaccine for prevention of shigellosis and typhoid fever.
JF  - Vaccine
AU  - Xu, De Qi
AU  - Cisar, John O
AU  - Osorio, Manuel
AU  - Wai, Tint T
AU  - Kopecko, Dennis J
AD  - Laboratory of Enteric and Sexually Transmitted Diseases, FDA-CBER, Bethesda, MD 20892, United States, dennis.kopecko@fda.hhs.gov
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 6167
EP  - 6175
PB  - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl]
VL  - 25
IS  - 33
SN  - 0264-410X, 0264-410X
KW  - Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW  - Bifunctional vaccine
KW  - Oral vaccine
KW  - Typhoid-Shigella vaccine
KW  - Heterologous LPS expression
KW  - Shigella dysenteriae 1
KW  - Salmonella Typhi Ty21a
KW  - Live bacterial vector
KW  - Mortality
KW  - Serotypes
KW  - Salmonella typhi
KW  - Shigella
KW  - Immunity
KW  - Plasmids
KW  - Immunization
KW  - Shigella dysenteriae
KW  - Expression vectors
KW  - Promoters
KW  - Antibodies
KW  - Immunogenicity
KW  - Shigellosis
KW  - Salmonella enterica
KW  - Lipopolysaccharides
KW  - Vaccines
KW  - Typhoid fever
KW  - F 06905:Vaccines
KW  - J 02350:Immunology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Mortality; Serotypes; Immunity; Plasmids; Immunization; Expression vectors; Promoters; Antibodies; Shigellosis; Immunogenicity; Lipopolysaccharides; Vaccines; Typhoid fever; Salmonella typhi; Salmonella enterica; Shigella; Shigella dysenteriae
DO  - http://dx.doi.org/10.1016/j.vaccine.2007.06.003
ER  - 



TY  - JOUR
T1  - Rapid and widespread dissemination of multidrug-resistant bla sub(CMY-2) Salmonella Typhimurium in Mexico
AN  - 20299574; 7530557
AB  - OBJECTIVES: We describe the emergence and dissemination of multidrug-resistant (MDR) Salmonella Typhimurium in humans, retail meat and food animals from Yucatan, Mexico. METHODS: Salmonella Typhimurium isolates were collected through an active surveillance system and tested for susceptibility to 12 antimicrobial agents. Isolates that were non-susceptible to ceftriaxone were tested with 10 additional antimicrobials and assayed by PCR for the presence of CMY, CTX-M, SHV, TEM and OXA {szligbeta}-lactamase genes. Plasmid-borne phenotypes were identified by transfer to susceptible Escherichia coli. Isolates from humans, retail meat and food animals were compared by PFGE to determine genetic relatedness. RESULTS: MDR Salmonella Typhimurium containing a plasmid-mediated bla sub(CMY-2) AmpC {szligbeta}-lactamase rose from 0% (0/27) during 2000 and 2001 to 75% (63/84) in 2004 and 2005 (P < 0.0001). MDR bla sub(CMY-2) Salmonella Typhimurium (n = 115) was most common in ill children (44.3%) and pork or swine intestine (36.5%). In several cities, MDR bla sub(CMY-2) Salmonella Typhimurium from retail meat or swine intestine exhibited PFGE patterns and antibiograms indistinguishable from those in strains recovered from hospitalized children. The CMY gene was transferred to E. coli by electroporation, along with resistance to three to six other antimicrobials. Children with MDR bla sub(CMY-2) Salmonella Typhimurium infection (n = 39) had a higher frequency of systemic infection (13% versus 0%), mortality (8% versus 0%) and hospital re-admission due to protracted diarrhoea (28% versus 17%) than children with non-MDR-Salmonella Typhimurium (n = 24), although the difference was not statistically significant. CONCLUSIONS: The rapid and widespread dissemination of MDR bla sub(CMY-2) Salmonella Typhimurium in Mexico calls for urgent interventions to contain this potentially fatal pathogen.
JF  - Journal of Antimicrobial Chemotherapy
AU  - Zaidi, Mussaret B
AU  - Leon, Veronica
AU  - Canche, Claudia
AU  - Perez, Carolina
AU  - Zhao, Shaohua
AU  - Hubert, Susannah K
AU  - Abbott, Jason
AU  - Blickenstaff, Karen
AU  - McDermott, Patrick F
AD  - Depto. de Investigacion, Laboratorio de Investigacion, Hospital General O'Horan, Av. Itzaes x Jacinto Canek, Merida C.P. 97000, Yucatan, Mexico. Center for Veterinary Medicine, Food and Drug Administration, Laurel, MD, USA
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 398
EP  - 401
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 60
IS  - 2
SN  - 0305-7453, 0305-7453
KW  - Microbiology Abstracts B: Bacteriology
KW  - Mortality
KW  - Diarrhea
KW  - Electroporation
KW  - Food
KW  - Disseminated infection
KW  - Pork
KW  - Statistical analysis
KW  - Pathogens
KW  - Ceftriaxone
KW  - Salmonella typhimurium
KW  - Children
KW  - Antimicrobial agents
KW  - Meat
KW  - Escherichia coli
KW  - Intestine
KW  - Polymerase chain reaction
KW  - Hospitals
KW  - J 02340:Antibiotics & Antimicrobials
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Mortality; Diarrhea; Electroporation; Food; Disseminated infection; Statistical analysis; Pork; Ceftriaxone; Pathogens; Children; Antimicrobial agents; Meat; Intestine; Polymerase chain reaction; Hospitals; Escherichia coli; Salmonella typhimurium
ER  - 



TY  - JOUR
T1  - Toll-Like Receptor 2-Mediated Signaling Requirements for Francisella tularensis Live Vaccine Strain Infection of Murine Macrophages
AN  - 20298806; 7530505
AB  - Francisella tularensis, an aerobic, non-spore-forming, gram-negative coccobacillus, is the causative agent of tularemia. We reported previously that F. tularensis live vaccine strain (LVS) elicited strong, dose-dependent NF- Kappa B reporter activity in Toll-like receptor 2 (TLR2)-expressing HEK293T cells and proinflammatory gene expression in primary murine macrophages. Herein, we report that F. tularensis LVS-induced murine macrophage proinflammatory cytokine gene and protein expression are overwhelmingly TLR2 dependent, as evidenced by the abrogated responses of TLR2 super(-/-) macrophages. F. tularensis LVS infection also increased expression of TLR2 both in vitro, in mouse macrophages, and in vivo, in livers from F. tularensis LVS-infected mice. Colocalization of intracellular F. tularensis LVS, TLR2, and MyD88 was visualized by confocal microscopy. Signaling was abrogated if the F. tularensis LVS organisms were heat or formalin killed or treated with chloramphenicol, indicating that the TLR2 agonist activity is dependent on new bacterial protein synthesis. F. tularensis LVS replicates in macrophages; however, bacterial replication was not required for TLR2 signaling because LVS Delta guaA, an F. tularensis LVS guanine auxotroph that fails to replicate in the absence of exogenous guanine, activated NF- Kappa B in TLR2-transfected HEK293T cells and induced cytokine expression in wild-type macrophages comparably to wild-type F. tularensis LVS. Collectively, these data indicate that the primary macrophage response to F. tularensis LVS is overwhelmingly TLR2 dependent, requires de novo bacterial protein synthesis, and is independent of intracellular F. tularensis replication.
JF  - Infection and Immunity
AU  - Cole, Leah E
AU  - Shirey, Kari Ann
AU  - Barry, Eileen
AU  - Santiago, Araceli
AU  - Rallabhandi, Prasad
AU  - Elkins, Karen L
AU  - Puche, Adam C
AU  - Michalek, Suzanne M
AU  - Vogel, Stefanie N
AD  - Department of Microbiology and Immunology. Center for Vaccine Development. Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201. Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Allergenic, and Parasitic Products, CBER, Food and Drug Administration, Bethesda, Maryland 20852. Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 4127
EP  - 4137
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 75
IS  - 8
SN  - 0019-9567, 0019-9567
KW  - Immunology Abstracts; Microbiology Abstracts B: Bacteriology
KW  - Macrophages
KW  - Chloramphenicol
KW  - Protein biosynthesis
KW  - Replication
KW  - Auxotrophs
KW  - MyD88 protein
KW  - TLR2 protein
KW  - Formaldehyde
KW  - Francisella tularensis
KW  - Infection
KW  - Inflammation
KW  - NF- Kappa B protein
KW  - Gene expression
KW  - Tularemia
KW  - Guanine
KW  - Heat
KW  - Confocal microscopy
KW  - Liver
KW  - Cytokines
KW  - Vaccines
KW  - Toll-like receptors
KW  - Signal transduction
KW  - J 02350:Immunology
KW  - F 06910:Microorganisms & Parasites
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-08-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Macrophages; Chloramphenicol; Protein biosynthesis; MyD88 protein; Auxotrophs; Replication; TLR2 protein; Formaldehyde; Infection; NF- Kappa B protein; Inflammation; Gene expression; Guanine; Tularemia; Heat; Confocal microscopy; Liver; Cytokines; Vaccines; Toll-like receptors; Signal transduction; Francisella tularensis
ER  - 



TY  - JOUR
T1  - The Large Clostridial Toxins from Clostridium sordellii and C. difficile Repress Glucocorticoid Receptor Activity
AN  - 20297720; 7530484
AB  - We have previously shown that Bacillus anthracis lethal toxin represses glucocorticoid receptor (GR) transactivation. We now report that repression of GR activity also occurs with the large clostridial toxins produced by Clostridium sordellii and C. difficile. This was demonstrated using a transient transfection assay system for GR transactivation. We also report that C. sordellii lethal toxin inhibited GR function in an ex vivo assay, where toxin reduced the dexamethasone suppression of the proinflammatory cytokine tumor necrosis factor alpha (TNF- alpha ). Furthermore, the glucocorticoid antagonist RU-486 in combination with C. sordellii lethal toxin additively prevented glucocorticoid suppression of TNF- alpha . These findings corroborate the fact that GR is a target for the toxin and suggest a physiological role for toxin-associated GR repression in inflammation. Finally, we show that this repression is associated with toxins that inactivate p38 mitogen-activated protein kinase (MAPK).
JF  - Infection and Immunity
AU  - Tait, ASasha
AU  - Dalton, Monique
AU  - Geny, Blandine
AU  - D'Agnillo, Felice
AU  - Popoff, Michel R
AU  - Sternberg, Esther M
AD  - Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, NIH, Rockville, Maryland. Unite des Bacteries Anaerobes et Toxines, Institut Pasteur, Paris, France. Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 3935
EP  - 3940
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 75
IS  - 8
SN  - 0019-9567, 0019-9567
KW  - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW  - Dexamethasone
KW  - MAP kinase
KW  - Glucocorticoid receptors
KW  - Clostridium sordellii
KW  - Transfection
KW  - Cytokines
KW  - Tumor necrosis factor- alpha
KW  - Bacillus anthracis
KW  - Glucocorticoids
KW  - Toxins
KW  - Inflammation
KW  - X 24370:Natural Toxins
KW  - J 02330:Biochemistry
KW  - F 06910:Microorganisms & Parasites
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-08-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Dexamethasone; MAP kinase; Glucocorticoid receptors; Transfection; Cytokines; Tumor necrosis factor- alpha; Glucocorticoids; Toxins; Inflammation; Clostridium sordellii; Bacillus anthracis
ER  - 



TY  - JOUR
T1  - Development and Validation of DNA Microarray for Genotyping Group A Rotavirus VP4 (P[4], P[6], P[8], P[9], and P[14]) and VP7 (G1 to G6, G8 to G10, and G12) Genes
AN  - 20091633; 7558216
AB  - Previously, we reported the development of a microarray-based method for the identification of five clinically relevant G genotypes (G1 to G4 and G9) (V. Chizhikov et al., J. Clin. Microbiol. 40:2398-2407, 2002). The expanded version of the rotavirus microarray assay presented herein is capable of identifying (i) five clinically relevant human rotavirus VP4 genotypes (P[4], P[6], P[8], P[9], and P[14]) and (ii) five additional human rotavirus VP7 genotypes (G5, G6, G8, G10, and G12) on one chip. Initially, a total of 80 cell culture-adapted human and animal reference rotavirus strains of known P (P[1] to P[12], P[14], P[16], and P[20]) and G (G1-6, G8 to G12, and G14) genotypes isolated in various parts of the world were employed to evaluate the new microarray assay. All rotavirus strains bearing P[4], P[6], P[8], P[9], or P[14] and/or G1 to G6, G8 to G10, or G12 specificity were identified correctly. In addition, cross-reactivity to viruses of genotype G11, G13, or G14 or P[1] to P[3], P[5], P[7], P[10] to P[12], P[16], or P[20] was not observed. Next, we analyzed a total of 128 rotavirus-positive human stool samples collected in three countries (Brazil, Ghana, and the United States) by this assay and validated its usefulness. The results of this study showed that the assay was sensitive and specific and capable of unambiguously discriminating mixed rotavirus infections from nonspecific cross-reactivity; the inability to discriminate mixed infections from nonspecific cross-reactivity is one of the inherent shortcomings of traditional multiplex reverse transcription-PCR genotyping. Moreover, because the hybridization patterns exhibited by rotavirus strains of different genotypes can vary, this method may be ideal for analyzing the genetic polymorphisms of the VP7 or VP4 genes of rotaviruses.
JF  - Journal of Clinical Microbiology
AU  - Honma, Shinjiro
AU  - Chizhikov, Vladimir
AU  - Santos, Norma
AU  - Tatsumi, Masatoshi
AU  - do Carmo S. T. Timenetsky, Maria
AU  - Linhares, Alexandre C
AU  - Mascarenhas, Joana D'Arc P
AU  - Ushijima, Hiroshi
AU  - Armah, George E
AU  - Gentsch, Jon R
AU  - Hoshino, Yasutaka
AD  - Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Laboratory of Method Development, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland. Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janerio, Brazil. Instituto Adolfo Lutz, Sao Paulo, Brazil. Instituto Evandro Chagas, Secretaria de Vigilancia em Saude, Belem, Brazil. University of Tokyo, Tokyo, Japan. University of Ghana, Legon, Ghana. Gastroenteritis and Respiratory Viruses Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 2641
EP  - 2648
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 45
IS  - 8
SN  - 0095-1137, 0095-1137
KW  - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts
KW  - Rotavirus
KW  - Cross-reactivity
KW  - Human rotavirus
KW  - Genotyping
KW  - Gene polymorphism
KW  - Genotypes
KW  - Feces
KW  - Group a rotavirus
KW  - DNA microarrays
KW  - Mixed infection
KW  - W 30910:Imaging
KW  - V 22300:Methods
KW  - G 07730:Development & Cell Cycle
KW  - N 14810:Methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Cross-reactivity; Gene polymorphism; Genotyping; Genotypes; Feces; DNA microarrays; Mixed infection; Rotavirus; Human rotavirus; Group a rotavirus
ER  - 



TY  - JOUR
T1  - Significance analysis of groups of genes in expression profiling studies
AN  - 20043296; 7609323
AB  - MOTIVATION: Gene class testing (GCT) is a statistical approach to determine whether some functionally predefined classes of genes express differently under two experimental conditions. GCT computes the P-value of each gene class based on the null distribution and the gene classes are ranked for importance in accordance with their P-values. Currently, two null hypotheses have been considered: the Q1 hypothesis tests the relative strength of association with the phenotypes among the gene classes, and the Q2 hypothesis assesses the statistical significance. These two hypotheses are related but not equivalent. METHOD: We investigate three one-sided and two two-sided test statistics under Q1 and Q2. The null distributions of gene classes under Q1 are generated by permuting gene labels and the null distributions under Q2 are generated by permuting samples. RESULTS: We applied the five statistics to a diabetes dataset with 143 gene classes and to a breast cancer dataset with 508 GO (Gene Ontology) terms. In each statistic, the null distributions of the gene classes under Q1 are different from those under Q2 in both datasets, and their rankings can be different too. We clarify the one-sided and two-sided hypotheses, and discuss some issues regarding the Q1 and Q2 hypotheses for gene class ranking in the GCT. Because Q1 does not deal with correlations among genes, we prefer test based on Q2. CONTACT: jchenatnctr.fda.gov Supplementary information: Supplementary data are available at Bioinformatics online.
JF  - Bioinformatics
AU  - Chen, James J
AU  - Lee, Taewon
AU  - Delongchamp, Robert R
AU  - Chen, Tao
AU  - Tsai, Chen-An
AD  - Division of Personalized Nutrition and Medicine, Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA Institute of Statistical Science, Academia Sinica, Taipei, Taiwan and Biostatistics Center, China Medical University, Taichung, Taiwan
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 2104
EP  - 2112
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 23
IS  - 16
SN  - 1367-4803, 1367-4803
KW  - Genetics Abstracts; Biotechnology and Bioengineering Abstracts
KW  - Diabetes mellitus
KW  - Statistics
KW  - Data processing
KW  - Statistical analysis
KW  - Breast cancer
KW  - Bioinformatics
KW  - double prime GO gene
KW  - G 07880:Human Genetics
KW  - W 30960:Bioinformatics & Computer Applications
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-10-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Diabetes mellitus; Data processing; Statistics; Statistical analysis; Breast cancer; Bioinformatics; double prime GO gene
ER  - 



TY  - JOUR
T1  - Identification and molecular characterization of Salmonella spp. from unpasteurized orange juices and identification of new serotype Salmonella strain S. enterica serovar Tempe
AN  - 19991466; 7428919
AB  - Several Salmonella enterica serotypes were isolated from unpasteurized orange juice samples analysed as a follow-up to an outbreak in 1999 of S. enterica serotype Muenchen in the Pacific Northwest regions of United States. Eleven S. enterica strains were serotyped and identified as S. enterica serotype Muenchen (2), S. enterica serotype Hidalgo (2), S. enterica serotype Alamo (1), S. enterica serotype Gaminera (2), S. enterica serotype Javiana (2) and a new serotyped strain S. enterica serotype Tempe (2). The identity of the new serotype S. enterica serovar Tempe serotype 30:b:1,7:z33 was confirmed by the National Salmonella Reference Laboratory at NCID/CDC, Atlanta. These strains were sensitive to ampicillin, chloramphenicol, kanamycin, tetracycline, streptomycin and sulfisoxazole antibiotics. Isolates were screened for invasion (invA) and virulence (spvC) genes using specific primers for these two genes by polymerase chain reaction. All strains were positive for invA gene giving 321-bp fragment, however negative to virulence spvC gene. For pulsed-field gel electrophoresis (PFGE) analysis, Salmonella strain plugs were made and digested with XbaI and subjected to 18-h electrophoresis. The PFGE patterns were different for each S. enterica serotypes suggesting the several origins of contamination in outbreak. S. enterica serotype.
JF  - Food Microbiology
AU  - Khan, A A
AU  - Melvin, C D
AU  - Dagdag, E B
AD  - US Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA, Ashraf.khan@fda.hhs.gov
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 539
EP  - 543
PB  - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 24
IS  - 5
SN  - 0740-0020, 0740-0020
KW  - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - Citrus
KW  - Chloramphenicol
KW  - Serotypes
KW  - Ampicillin
KW  - Sulfisoxazole
KW  - Kanamycin
KW  - Antibiotics
KW  - Streptomycin
KW  - Food contamination
KW  - Tetracyclines
KW  - Virulence
KW  - Fruit juices
KW  - Salmonella enterica
KW  - Pulsed-field gel electrophoresis
KW  - Polymerase chain reaction
KW  - Primers
KW  - J 02310:Genetics & Taxonomy
KW  - A 01330:Food Microbiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-06-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Chloramphenicol; Serotypes; Sulfisoxazole; Ampicillin; Antibiotics; Kanamycin; Streptomycin; Tetracyclines; Food contamination; Virulence; Fruit juices; Pulsed-field gel electrophoresis; Polymerase chain reaction; Primers; Citrus; Salmonella enterica
DO  - http://dx.doi.org/10.1016/j.fm.2006.09.002
ER  - 



TY  - JOUR
T1  - Comparative Mortality for 621 Second Cancers in 29356 Testicular Cancer Survivors and 12420 Matched First Cancers
AN  - 19743285; 7558835
AB  - BACKGROUND: Testicular cancer survivors, many of whom have undergone radiotherapy, are at substantial risk of second cancers. Treatment for testicular cancer may limit treatment options for second cancers, thereby adversely affecting survival after the second cancer. However, no data on outcomes of testicular cancer survivors with second cancers compared to patients with comparable first cancers exist. METHODS: Among 29356 white testicular cancer patients reported to the Surveillance, Epidemiology, and End Results (SEER) program (1973-2002), 621 developed a second cancer with known stage and were matched to a random sample of 12420 white male first cancer patients in the SEER program by cancer site, stage, diagnosis year, and age at diagnosis. Mortality was ascertained through 2002. Cancer-specific and all-cause mortality following second cancers were compared with those of matched first cancers, and rate ratios (RRs) were estimated using proportional hazards analysis. Survival functions were calculated using product-limit estimates. RESULTS: During the study period, 284 testicular cancer survivors with second cancers died, 191 from their second cancer; 5443 matched first cancer patients died, 3929 from their first cancer. Rate ratios for cancer-specific and all-cause mortality for second cancers compared with matched first cancers were 1.05 (95% confidence interval [CI] = 0.90 to 1.23) and 1.09 (95% CI = 0.96 to 1.23), respectively. However, among testicular cancer patients who were diagnosed during 1973-1979, an era in which radiation therapy was given at high doses and to the chest area, all-cause mortality following second cancers at sites below the diaphragm (79 deaths) and second lung cancers (29 deaths) was statistically significantly higher than that from matched first cancers (RR = 1.44, 95% CI = 1.13 to 1.83, and RR = 1.65, 95% CI = 1.12 to 2.42, respectively). CONCLUSIONS: Mortality from second cancers following testicular cancer was similar to matched first cancers, except for selected tumors in the radiotherapy field among testicular cancer patients who were diagnosed during 1973-1979, a time when radiotherapy doses for treatment of testicular cancer were high and chest irradiation was an option in standard practice.
JF  - Journal of the National Cancer Institute
AU  - Schairer, Catherine
AU  - Hisada, Michie
AU  - Chen, Bingshu E
AU  - Brown, Linda M
AU  - Howard, Regan
AU  - Fossaa, Sophie D
AU  - Gail, Mitchell
AU  - Travis, Lois B
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (CS, MH, BEC, LMB, RH, MG, LBT)
Y1  - 2007/08//
PY  - 2007
DA  - Aug 2007
SP  - 1248
EP  - 1256
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 99
IS  - 16
SN  - 0027-8874, 0027-8874
KW  - Risk Abstracts
KW  - Radiation therapy
KW  - Mortality
KW  - survival
KW  - Lung cancer
KW  - R2 23060:Medical and environmental health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Radiation therapy; Mortality; survival; Lung cancer
ER  - 



TY  - RPRT
T1  - NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) CINCINNATI LABORATORY CONSOLIDATION, HAMILTON AND CLERMONT COUNTIES, OHIO. [Part 2 of 2]
T2  - NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) CINCINNATI LABORATORY CONSOLIDATION, HAMILTON AND CLERMONT COUNTIES, OHIO.
AN  - 756824416; 12872-070329_0002
AB  - PURPOSE: Six parcels of land, including three in the vicinity of Cincinnati in Hamilton County and three in Clermont County, Ohio are identified analyzed as sites for the construction and operation of facilities that would allow for consolidation the National Institute of Occupations Safety and Health (NIOSH) Laboratories. NIOSH is a subdivision of the Centers for Disease Control and prevention. The NIOSH Laboratories are currently operated within 334,000 gross square feet (gsf) of space located at the Robert A. Taft and Taft North buildings and at the Alice Hamilton Laboratory building, both of which lie in the city of Cincinnati. These existing facilities, which are separated by a distance of five miles, are outdated and inefficient, hence, cannot meet current NIOSH mission requirements. The proposed facility would have a minimum of 350,000 gsf and an additional 250,00 gsf of parking space. The candidate sites in Hamilton County include a 19-acre within the 143-acre TechSolve Business Park, located in the Bond Hill neighborhood of Cincinnati; the 25-acre Millcreek Psychiatric Center site, located less than one mile from access to Interstate 75 (I-75) and State Route 42 and six miles from the Cincinnati central business district; and the 15-acre Summit Outparcel site, located within the grounds of the Summit Behavioral State Hospital on Seymour Road in Cincinnati. The candidate sites in Clermont County include a 36-acre site within the 100-acre Ivy Pointe Commerce Park, located immediately east of I-275 on Ferguson Drive in Union Township; the 202-acre Ridgewood Corporate Center on Summit Drive in the Miami Township; and the 102-acre Miami Commons sites in the Miami Township. In addition to the site alternatives associated with the proposed action, this final EIS considers a No Action Alternative. POSITIVE IMPACTS: Consolidation of all NIOSH Laboratories facilities at one site would improve communication among researchers, centralize related projects, and improve program efficiency and effectiveness. The new facilities would offer a safer environment for storing and handling biological and chemical agents used by the laboratories in their research efforts. By maintaining the NIOSH facilities in Cincinnati, the proposed consolidation would maintain the valuable research partnership with the University of Cincinnati and the U.S. Environmental Protection Agency, both of whom have associated facilities in the city. In addition, continuation of siting the laboratories in Cincinnati would avoid severe long-term disruption of NIOSH programs due to relocation, ensure the flexibility of continued operations and surge capacity, and avoid the significant costs related to long-distance relocations. If the Ivy Point Commerce Park site were chosen, the city of Milford would benefit from an additional $539,500 in annual tax revenues. NEGATIVE IMPACTS: All candidate sites, excepting the Summit Outparcel site, contain wetlands that could be affected by laboratory development and operations. Depending on the site chosen, the project would displace woodland and old field, vacant buildings, recently graded vacant land, or farmland. The Ridgewood and Miami Commons sites have yet to be surveyed for occurrence of endangered species; the other sites have been surveyed and contain no significant habitat for protected species. No cultural resource survey has been completed for an site. Development at any sites would increase stormwater runoff into local receiving surface flows. Movement of the laboratories outside Cincinnati would reduce annual municipal tax revenues by $1.4 million. Noise emitted at the Ridgewood Corporate Center or Miami Commons site would affect one or more local resident. LEGAL MANDATES: Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.).
JF  - EPA number: 070329, 722 pages, July 30, 2007
PY  - 2007
VL  - 2
KW  - Land Use
KW  - Buildings
KW  - Farmlands
KW  - Forests
KW  - Health Hazard Analyses
KW  - Health Hazards
KW  - Noise
KW  - Research Facilities
KW  - Safety
KW  - Safety Analyses
KW  - Wetlands
KW  - Ohio
KW  - Federal Water Pollution Control Act of 1972, Section 404 Permits
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Name - General Services Administration, Atlanta, Georgia and Chicago, Illinois; GSA
N1  - Date revised - 2008-04-01
N1  - SuppNotes - Final. Preparation date: July 30, 2007
N1  - Last updated - 2011-12-16
ER  - 



TY  - RPRT
T1  - NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) CINCINNATI LABORATORY CONSOLIDATION, HAMILTON AND CLERMONT COUNTIES, OHIO. [Part 1 of 2]
T2  - NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) CINCINNATI LABORATORY CONSOLIDATION, HAMILTON AND CLERMONT COUNTIES, OHIO.
AN  - 756824382; 12872-070329_0001
AB  - PURPOSE: Six parcels of land, including three in the vicinity of Cincinnati in Hamilton County and three in Clermont County, Ohio are identified analyzed as sites for the construction and operation of facilities that would allow for consolidation the National Institute of Occupations Safety and Health (NIOSH) Laboratories. NIOSH is a subdivision of the Centers for Disease Control and prevention. The NIOSH Laboratories are currently operated within 334,000 gross square feet (gsf) of space located at the Robert A. Taft and Taft North buildings and at the Alice Hamilton Laboratory building, both of which lie in the city of Cincinnati. These existing facilities, which are separated by a distance of five miles, are outdated and inefficient, hence, cannot meet current NIOSH mission requirements. The proposed facility would have a minimum of 350,000 gsf and an additional 250,00 gsf of parking space. The candidate sites in Hamilton County include a 19-acre within the 143-acre TechSolve Business Park, located in the Bond Hill neighborhood of Cincinnati; the 25-acre Millcreek Psychiatric Center site, located less than one mile from access to Interstate 75 (I-75) and State Route 42 and six miles from the Cincinnati central business district; and the 15-acre Summit Outparcel site, located within the grounds of the Summit Behavioral State Hospital on Seymour Road in Cincinnati. The candidate sites in Clermont County include a 36-acre site within the 100-acre Ivy Pointe Commerce Park, located immediately east of I-275 on Ferguson Drive in Union Township; the 202-acre Ridgewood Corporate Center on Summit Drive in the Miami Township; and the 102-acre Miami Commons sites in the Miami Township. In addition to the site alternatives associated with the proposed action, this final EIS considers a No Action Alternative. POSITIVE IMPACTS: Consolidation of all NIOSH Laboratories facilities at one site would improve communication among researchers, centralize related projects, and improve program efficiency and effectiveness. The new facilities would offer a safer environment for storing and handling biological and chemical agents used by the laboratories in their research efforts. By maintaining the NIOSH facilities in Cincinnati, the proposed consolidation would maintain the valuable research partnership with the University of Cincinnati and the U.S. Environmental Protection Agency, both of whom have associated facilities in the city. In addition, continuation of siting the laboratories in Cincinnati would avoid severe long-term disruption of NIOSH programs due to relocation, ensure the flexibility of continued operations and surge capacity, and avoid the significant costs related to long-distance relocations. If the Ivy Point Commerce Park site were chosen, the city of Milford would benefit from an additional $539,500 in annual tax revenues. NEGATIVE IMPACTS: All candidate sites, excepting the Summit Outparcel site, contain wetlands that could be affected by laboratory development and operations. Depending on the site chosen, the project would displace woodland and old field, vacant buildings, recently graded vacant land, or farmland. The Ridgewood and Miami Commons sites have yet to be surveyed for occurrence of endangered species; the other sites have been surveyed and contain no significant habitat for protected species. No cultural resource survey has been completed for an site. Development at any sites would increase stormwater runoff into local receiving surface flows. Movement of the laboratories outside Cincinnati would reduce annual municipal tax revenues by $1.4 million. Noise emitted at the Ridgewood Corporate Center or Miami Commons site would affect one or more local resident. LEGAL MANDATES: Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.).
JF  - EPA number: 070329, 722 pages, July 30, 2007
PY  - 2007
VL  - 1
KW  - Land Use
KW  - Buildings
KW  - Farmlands
KW  - Forests
KW  - Health Hazard Analyses
KW  - Health Hazards
KW  - Noise
KW  - Research Facilities
KW  - Safety
KW  - Safety Analyses
KW  - Wetlands
KW  - Ohio
KW  - Federal Water Pollution Control Act of 1972, Section 404 Permits
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Name - General Services Administration, Atlanta, Georgia and Chicago, Illinois; GSA
N1  - Date revised - 2008-04-01
N1  - SuppNotes - Final. Preparation date: July 30, 2007
N1  - Last updated - 2011-12-16
ER  - 



TY  - RPRT
T1  - NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) CINCINNATI LABORATORY CONSOLIDATION, HAMILTON AND CLERMONT COUNTIES, OHIO.
AN  - 36343617; 12872
AB  - PURPOSE: Six parcels of land, including three in the vicinity of Cincinnati in Hamilton County and three in Clermont County, Ohio are identified analyzed as sites for the construction and operation of facilities that would allow for consolidation the National Institute of Occupations Safety and Health (NIOSH) Laboratories. NIOSH is a subdivision of the Centers for Disease Control and prevention. The NIOSH Laboratories are currently operated within 334,000 gross square feet (gsf) of space located at the Robert A. Taft and Taft North buildings and at the Alice Hamilton Laboratory building, both of which lie in the city of Cincinnati. These existing facilities, which are separated by a distance of five miles, are outdated and inefficient, hence, cannot meet current NIOSH mission requirements. The proposed facility would have a minimum of 350,000 gsf and an additional 250,00 gsf of parking space. The candidate sites in Hamilton County include a 19-acre within the 143-acre TechSolve Business Park, located in the Bond Hill neighborhood of Cincinnati; the 25-acre Millcreek Psychiatric Center site, located less than one mile from access to Interstate 75 (I-75) and State Route 42 and six miles from the Cincinnati central business district; and the 15-acre Summit Outparcel site, located within the grounds of the Summit Behavioral State Hospital on Seymour Road in Cincinnati. The candidate sites in Clermont County include a 36-acre site within the 100-acre Ivy Pointe Commerce Park, located immediately east of I-275 on Ferguson Drive in Union Township; the 202-acre Ridgewood Corporate Center on Summit Drive in the Miami Township; and the 102-acre Miami Commons sites in the Miami Township. In addition to the site alternatives associated with the proposed action, this final EIS considers a No Action Alternative. POSITIVE IMPACTS: Consolidation of all NIOSH Laboratories facilities at one site would improve communication among researchers, centralize related projects, and improve program efficiency and effectiveness. The new facilities would offer a safer environment for storing and handling biological and chemical agents used by the laboratories in their research efforts. By maintaining the NIOSH facilities in Cincinnati, the proposed consolidation would maintain the valuable research partnership with the University of Cincinnati and the U.S. Environmental Protection Agency, both of whom have associated facilities in the city. In addition, continuation of siting the laboratories in Cincinnati would avoid severe long-term disruption of NIOSH programs due to relocation, ensure the flexibility of continued operations and surge capacity, and avoid the significant costs related to long-distance relocations. If the Ivy Point Commerce Park site were chosen, the city of Milford would benefit from an additional $539,500 in annual tax revenues. NEGATIVE IMPACTS: All candidate sites, excepting the Summit Outparcel site, contain wetlands that could be affected by laboratory development and operations. Depending on the site chosen, the project would displace woodland and old field, vacant buildings, recently graded vacant land, or farmland. The Ridgewood and Miami Commons sites have yet to be surveyed for occurrence of endangered species; the other sites have been surveyed and contain no significant habitat for protected species. No cultural resource survey has been completed for an site. Development at any sites would increase stormwater runoff into local receiving surface flows. Movement of the laboratories outside Cincinnati would reduce annual municipal tax revenues by $1.4 million. Noise emitted at the Ridgewood Corporate Center or Miami Commons site would affect one or more local resident. LEGAL MANDATES: Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.).
JF  - EPA number: 070329, 722 pages, July 30, 2007
PY  - 2007
KW  - Land Use
KW  - Buildings
KW  - Farmlands
KW  - Forests
KW  - Health Hazard Analyses
KW  - Health Hazards
KW  - Noise
KW  - Research Facilities
KW  - Safety
KW  - Safety Analyses
KW  - Wetlands
KW  - Ohio
KW  - Federal Water Pollution Control Act of 1972, Section 404 Permits
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Name - General Services Administration, Atlanta, Georgia and Chicago, Illinois; GSA
N1  - Date revised - 2008-04-01
N1  - SuppNotes - Final. Preparation date: July 30, 2007
N1  - Last updated - 2011-12-16
ER  - 



TY  - CPAPER
T1  - The U.S. Perspective on the Global Strategy for Diet, Physical Activity and Health
T2  - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007)
AN  - 39426545; 4599467
JF  - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007)
AU  - Schneeman, Barbara O
Y1  - 2007/07/28/
PY  - 2007
DA  - 2007 Jul 28
KW  - USA
KW  - Physical activity
KW  - Diets
KW  - U 2000:Biological Sciences
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L2  - http://www.abstractsonline.com/viewer/?mkey=%7B50521FFC%2D4C00%2D4561% 2DAEBA%2D632C1175F44C%7D
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - When is a New Dietary Supplement Reasonably Expected to be Safe?
T2  - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007)
AN  - 39356493; 4599440
JF  - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007)
AU  - Frankos, Vasilios
Y1  - 2007/07/28/
PY  - 2007
DA  - 2007 Jul 28
KW  - Dietary supplements
KW  - U 2000:Biological Sciences
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L2  - http://www.abstractsonline.com/viewer/?mkey=%7B50521FFC%2D4C00%2D4561% 2DAEBA%2D632C1175F44C%7D
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Scientific Evidence for Making Health Claims on Foods and Food Ingredients
T2  - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007)
AN  - 39345860; 4599713
JF  - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007)
AU  - Kavanaugh, C
Y1  - 2007/07/28/
PY  - 2007
DA  - 2007 Jul 28
KW  - Food
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39345860?accountid=14244
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L2  - http://www.abstractsonline.com/viewer/?mkey=%7B50521FFC%2D4C00%2D4561% 2DAEBA%2D632C1175F44C%7D
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Comparison of Survival of Francisella tularensis in Various Beverages
T2  - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007)
AN  - 39338946; 4598616
JF  - 2007 Annual Meeting and Food Expo of the Institute of Food Technologists (IFT 2007)
AU  - Laird, David T
AU  - Stewart, Diana
AU  - Reineke, Karl
AU  - Tortorello, Mary Lou
Y1  - 2007/07/28/
PY  - 2007
DA  - 2007 Jul 28
KW  - Survival
KW  - Beverages
KW  - Francisella tularensis
KW  - U 2000:Biological Sciences
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L2  - http://www.abstractsonline.com/viewer/?mkey=%7B50521FFC%2D4C00%2D4561% 2DAEBA%2D632C1175F44C%7D
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - National Ambulatory Medical Care Survey: terrorism preparedness among office-based physicians, United States, 2003-2004.
AN  - 68174803; 17702147
AB  - This investigation describes terrorism preparedness among U.S. office-based physicians and their staffs in identification and diagnosis of terrorism-related conditions, training methods and sources, and assistance with diagnosis and reporting.
          The National Ambulatory Medical Care Survey (NAMCS) is an annual national probability survey of approximately 3,000 U.S. nonfederal, office-based physicians. Terrorism preparedness items were added in 2003 and 2004. About 40 percent of physicians or their staffs received training for anthrax or smallpox, but less than one-third received training for any of the other exposures. About 42.2 percent of physicians, 13.5 percent of nurses, and 9.4 percent of physician assistants and nurse practitioners received training in at least one exposure. Approximately 56.2 percent of physicians indicated that they would contact state or local public health officials for diagnostic assistance more frequently than federal agencies and other sources. About 67.1 percent of physicians indicated that they would report a suspected terrorism-related condition to the state or local health department, 50.9 percent to the Centers for Disease Control and Prevention (CDC), 27.5 percent to the local hospital, and 1.8 percent to a local elected official's office. Approximately 78.8 percent of physicians had contact information for the local health department readily available. About 53.7 percent had reviewed the diseases reportable to health departments since September 2001, 11.3 percent had reviewed them before that month, and 35 percent had never reviewed them.
JF  - Advance data
AU  - Niska, Richard W
AU  - Burt, Catharine W
AD  - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, MD 20782, USA.
Y1  - 2007/07/24/
PY  - 2007
DA  - 2007 Jul 24
SP  - 1
EP  - 10
IS  - 390
SN  - 0147-3956, 0147-3956
KW  - Health administration
KW  - United States
KW  - Teaching
KW  - Health Care Surveys
KW  - Humans
KW  - Ambulatory Care
KW  - Physicians' Offices
KW  - Chemical Terrorism
KW  - Disaster Planning
KW  - Bioterrorism
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advance+data&rft.atitle=National+Ambulatory+Medical+Care+Survey%3A+terrorism+preparedness+among+office-based+physicians%2C+United+States%2C+2003-2004.&rft.au=Niska%2C+Richard+W%3BBurt%2C+Catharine+W&rft.aulast=Niska&rft.aufirst=Richard&rft.date=2007-07-24&rft.volume=&rft.issue=390&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Advance+data&rft.issn=01473956&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-12
N1  - Date created - 2007-08-17
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Determination of quinolone residues in shrimp using liquid chromatography with fluorescence detection and residue confirmation by mass spectrometry.
AN  - 70688962; 17631104
AB  - The quinolones, oxolinic acid (OXO), flumequine (FLU), and nalidixic acid (NAL), are antibacterial drugs effective against gram-negative bacteria. Quinolones are used in both human and veterinary medicine, but are currently not approved by the U.S. Food and Drug Administration for use in food fish. A liquid chromatography-fluorescence (LC-FL) method was developed to determine OXO, FLU, and NAL residues in shrimp. An additional liquid chromatography-mass spectrometry (LC-MS(n)) method was created to confirm these residues using the same sample extract. Samples were prepared with a simple ethyl acetate extraction followed by solvent exchange into 0.2% formic acid and cleaned-up with hexane. Reverse phase chromatography was used to separate the three compounds in both procedures. For the LC-FL determinative method, fluorescence emission was monitored at 369 nm with excitation at 327 nm. With electrospray ionization, the three most abundant ions from the MS3 product ion spectrum were used to identify OXO, FLU, and NAL in the confirmation procedure. Shrimp samples fortified at levels ranging from 7.5 to 100 ng g(-1) were used to validate both methods.
JF  - Analytica chimica acta
AU  - Karbiwnyk, Christine M
AU  - Carr, Lori E
AU  - Turnipseed, Sherri B
AU  - Andersen, Wendy C
AU  - Miller, Keith E
AD  - Animal Drugs Research Center, Food and Drug Administration, Denver, CO, United States. christine.karbiwnyk@fda.hhs.gov
Y1  - 2007/07/23/
PY  - 2007
DA  - 2007 Jul 23
SP  - 257
EP  - 263
VL  - 596
IS  - 2
KW  - Quinolones
KW  - 0
KW  - Index Medicus
KW  - Animals
KW  - Chromatography, Liquid -- methods
KW  - Spectrometry, Fluorescence -- methods
KW  - Mass Spectrometry -- methods
KW  - Quinolones -- analysis
KW  - Decapoda (Crustacea) -- chemistry
KW  - Drug Residues -- analysis
KW  - Drug Residues -- chemistry
KW  - Quinolones -- chemistry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-07
N1  - Date created - 2007-07-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Impact of mobile radiographic screening on tuberculosis among drug users and homeless persons.
AN  - 70703610; 17413123
AB  - In 2002, a mobile radiographic screening program was started in Rotterdam to respond to high rates of tuberculosis (TB) among illicit drug users and homeless persons.
          We studied trends and characteristics of TB among these risk groups and assessed the impact of the screening program on transmission, using molecular typing. Description of trends, and of demographic and disease-related characteristics of tuberculosis cases among these risk groups between 1993 and 2005. TB was considered to result from recent transmission if the mycobacterial DNA fingerprints of cases were identical to those of other cases in the risk groups in the previous 2 years.
          During the study period, 206 individuals with TB among illicit drug users and homeless persons were notified, representing 11.4% of the total case load of 1,811 in Rotterdam. The annual number of tuberculosis cases declined from 24 at the start of the screening program to 11 cases in 2005. The screening program identified 28 cases (a prevalence rate of 327 per 100,000 radiographs), of which 12 were smear positive. In 1997-2002, more than 80% of the illicit drug users or homeless persons with TB were infected with one of the Mycobacterium tuberculosis strains prevalent among these risk groups. After nearly 4 years of systematic radiographic screening this proportion declined to 45% in 2005. DNA fingerprinting can be a useful tool to evaluate the impact of a TB screening program. We advocate that screening of illicit drug users and homeless persons should be continued to prevent a resurgence of TB.
JF  - American journal of respiratory and critical care medicine
AU  - de Vries, Gerard
AU  - van Hest, Rob A H
AU  - Richardus, Jan H
AD  - Department of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, P.O. Box 70032, 3000 LP Rotterdam, The Netherlands. devriesg@ggd.rotterdam.nl
Y1  - 2007/07/15/
PY  - 2007
DA  - 2007 Jul 15
SP  - 201
EP  - 207
VL  - 176
IS  - 2
SN  - 1073-449X, 1073-449X
KW  - Street Drugs
KW  - 0
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Netherlands -- epidemiology
KW  - Humans
KW  - Child
KW  - DNA Fingerprinting
KW  - Adult
KW  - Follow-Up Studies
KW  - Middle Aged
KW  - Radiography
KW  - Adolescent
KW  - Cluster Analysis
KW  - Female
KW  - Male
KW  - Mass Screening
KW  - Tuberculosis, Pulmonary -- transmission
KW  - Substance-Related Disorders -- microbiology
KW  - Substance-Related Disorders -- diagnostic imaging
KW  - Tuberculosis, Pulmonary -- diagnostic imaging
KW  - Mobile Health Units
KW  - Tuberculosis, Pulmonary -- epidemiology
KW  - Homeless Persons
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Impact+of+mobile+radiographic+screening+on+tuberculosis+among+drug+users+and+homeless+persons.&rft.au=de+Vries%2C+Gerard%3Bvan+Hest%2C+Rob+A+H%3BRichardus%2C+Jan+H&rft.aulast=de+Vries&rft.aufirst=Gerard&rft.date=2007-07-15&rft.volume=176&rft.issue=2&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-18
N1  - Date created - 2007-07-09
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
Am J Respir Crit Care Med. 2008 Mar 1;177(5):557-8 [18296473]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Cancer risk in women prenatally exposed to diethylstilbestrol.
AN  - 70537382; 17390375
AB  - Prenatal diethylstilbestrol (DES) exposure is associated with excess risks of clear cell adenocarcinoma (CCA), and breast cancer in older women. Whether overall cancer risk is also elevated is unclear. Total and site-specific cancer risks were evaluated in the DES Combined Cohort Follow-up Study using age- and calendar-year specific standardized incidence rate ratios (SIR), and age-adjusted incidence rate ratios (RR) comparing DES exposed and unexposed women. A total of 143 and 49 cancer cases occurred in 97,831 and 34,810 person-years among the exposed and unexposed, respectively. There was no overall excess risk among exposed women when compared with external rates (SIR 1.01; 95% confidence interval [CI] 0.86-1.2). The overall RR comparing exposed with unexposed women was 1.32 (95% CI 0.94-1.8). Breast cancer risk was elevated only among women over 40 years (RR 1.83; 95% CI 1.1-3.2). The CCA SIR among exposed women was nearly 40, and the estimated attack rate through age 39 was 1.6/1,000 women. CCA incidence decreased by over 80% after age 25 when compared with 20-24 years. Excluding CCA and breast cancer, the overall RR was 1.21 (95% CI 0.74-2.0). DES was not associated with excess risks of either endometrial or ovarian cancer. These data suggest that the DES associated increase in CCA incidence remains elevated through the reproductive years. There was no consistent evidence of risk excesses for cancers other than CCA, and breast cancer in older women. Given that the population is still young, continued follow-up is necessary to assess the overall carcinogenic impact of prenatal DES exposure. (c) 2007 Wiley-Liss, Inc.
JF  - International journal of cancer
AU  - Troisi, Rebecca
AU  - Hatch, Elizabeth E
AU  - Titus-Ernstoff, Linda
AU  - Hyer, Marianne
AU  - Palmer, Julie R
AU  - Robboy, Stanley J
AU  - Strohsnitter, William C
AU  - Kaufman, Raymond
AU  - Herbst, Arthur L
AU  - Hoover, Robert N
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. troisir@mail.nih.gov
Y1  - 2007/07/15/
PY  - 2007
DA  - 2007 Jul 15
SP  - 356
EP  - 360
VL  - 121
IS  - 2
SN  - 0020-7136, 0020-7136
KW  - Estrogens, Non-Steroidal
KW  - 0
KW  - Diethylstilbestrol
KW  - 731DCA35BT
KW  - Index Medicus
KW  - Regression Analysis
KW  - Risk Factors
KW  - Humans
KW  - Cohort Studies
KW  - Adult
KW  - Estrogens, Non-Steroidal -- therapeutic use
KW  - Incidence
KW  - Middle Aged
KW  - Follow-Up Studies
KW  - Estrogens, Non-Steroidal -- adverse effects
KW  - United States -- epidemiology
KW  - Female
KW  - Pregnancy
KW  - Diethylstilbestrol -- therapeutic use
KW  - Diethylstilbestrol -- adverse effects
KW  - Neoplasms -- chemically induced
KW  - Neoplasms -- epidemiology
KW  - Prenatal Exposure Delayed Effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Cancer+risk+in+women+prenatally+exposed+to+diethylstilbestrol.&rft.au=Troisi%2C+Rebecca%3BHatch%2C+Elizabeth+E%3BTitus-Ernstoff%2C+Linda%3BHyer%2C+Marianne%3BPalmer%2C+Julie+R%3BRobboy%2C+Stanley+J%3BStrohsnitter%2C+William+C%3BKaufman%2C+Raymond%3BHerbst%2C+Arthur+L%3BHoover%2C+Robert+N&rft.aulast=Troisi&rft.aufirst=Rebecca&rft.date=2007-07-15&rft.volume=121&rft.issue=2&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-06
N1  - Date created - 2007-05-24
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - Attenuation and Efficacy of Human Parainfluenza Virus Type 1 (HPIV1) Vaccine Candidates Containing Stabilized Mutations in the P/C and L Genes.
T2  - 26th Annual Meeting of the American Society for Virology (ASV 2007)
AN  - 39502073; 4677927
JF  - 26th Annual Meeting of the American Society for Virology (ASV 2007)
AU  - Bartlett, Emmalene J
AU  - Castano, Adam
AU  - Surman, Sonja R
AU  - Collins, Peter L
AU  - Skiadopoulos, Mario H
AU  - Murphy, Brian R
Y1  - 2007/07/14/
PY  - 2007
DA  - 2007 Jul 14
KW  - Mutation
KW  - Vaccines
KW  - Parainfluenza
KW  - Disease control
KW  - Parainfluenza virus
KW  - U 2000:Biological Sciences
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Attenuation+and+Efficacy+of+Human+Parainfluenza+Virus+Type+1+%28HPIV1%29+Vaccine+Candidates+Containing+Stabilized+Mutations+in+the+P%2FC+and+L+Genes.&rft.au=Bartlett%2C+Emmalene+J%3BCastano%2C+Adam%3BSurman%2C+Sonja+R%3BCollins%2C+Peter+L%3BSkiadopoulos%2C+Mario+H%3BMurphy%2C+Brian+R&rft.aulast=Bartlett&rft.aufirst=Emmalene&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - An Influenza a Matrix Gene Mutant Protected Mice Against Both Homologous and Heterologous Wild Type Influenza Viruses
T2  - 26th Annual Meeting of the American Society for Virology (ASV 2007)
AN  - 39501757; 4677816
JF  - 26th Annual Meeting of the American Society for Virology (ASV 2007)
AU  - Xie, Hang
AU  - Liu, Teresa
AU  - Ye, Zhiping
Y1  - 2007/07/14/
PY  - 2007
DA  - 2007 Jul 14
KW  - Influenza
KW  - Mice
KW  - Mutants
KW  - Viruses
KW  - Influenza A
KW  - U 2000:Biological Sciences
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L2  - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Mumps Virus Strain-Specific Antibody Neutralization and Waning Immunity Following Vaccination
T2  - 26th Annual Meeting of the American Society for Virology (ASV 2007)
AN  - 39488096; 4677925
JF  - 26th Annual Meeting of the American Society for Virology (ASV 2007)
AU  - Rubin, Steven
AU  - Li, Qi
AU  - Audet, Susette
AU  - Lebaron, Charles
AU  - Bellini, William
AU  - Rota, Paul
AU  - Carbone, Kathryn
AU  - Beeler, Judy
Y1  - 2007/07/14/
PY  - 2007
DA  - 2007 Jul 14
KW  - Neutralization
KW  - Vaccination
KW  - Antibodies
KW  - Mumps
KW  - Immunity
KW  - Mumps virus
KW  - U 2000:Biological Sciences
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L2  - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Single Amino Acid Changes within the Mumps Virus Hemagglutinin-Neuraminidase, Fusion and Polymerase Proteins Affect Protein Function and are Associated with Reduced Neurovirulence.
T2  - 26th Annual Meeting of the American Society for Virology (ASV 2007)
AN  - 39415692; 4677309
JF  - 26th Annual Meeting of the American Society for Virology (ASV 2007)
AU  - Malik, Tahir H
AU  - Wolbert, Candie
AU  - Mauldin, Jeremy
AU  - Sauder, Christian
AU  - Carbone, Kathryn M
AU  - Rubin, Steven A
Y1  - 2007/07/14/
PY  - 2007
DA  - 2007 Jul 14
KW  - Amino acids
KW  - Mumps
KW  - Amino acid sequence
KW  - Neurovirulence
KW  - Mumps virus
KW  - U 2000:Biological Sciences
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L2  - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory action.
AN  - 70722121; 17620536
AB  - Warfarin sodium is widely used and causes bleeding; a review might suggest the need for regulatory action by the US Food and Drug Administration (FDA).
          We accessed warfarin prescriptions from the National Prescription Audit Plus database of IMS Health (Plymouth Meeting, Pennsylvania), adverse event reports submitted to the FDA, deaths due to therapeutic use of anticoagulants from vital statistics data, and warfarin bleeding complications from national hospital emergency department data. The number of dispensed outpatient prescriptions for warfarin increased 45%, from 21 million in 1998 to nearly 31 million in 2004. The FDA's Adverse Event Reporting System indicated that warfarin is among the top 10 drugs with the largest number of serious adverse event reports submitted during the 1990 and 2000 decades. From US death certificates, anticoagulants ranked first in 2003 and 2004 in the number of total mentions of deaths for drugs causing "adverse effects in therapeutic use." Data from hospital emergency departments for 1999 through 2003 indicated that warfarin was associated with about 29 000 visits for bleeding complications per year, and it was among the drugs with the most visits. These data are consistent with literature reports of major bleeding frequencies for warfarin as high as 10% to 16%.
          Use of warfarin has increased, and bleeding from warfarin use is a prevalent reaction and an important cause of mortality. Consequently, a "black box" warning about warfarin's bleeding risk was added to the US product labeling in 2006. Physicians and nurses should tell patients to immediately report signs and symptoms of bleeding. A Medication Guide, which is required to be provided with each prescription, reinforces this message.
JF  - Archives of internal medicine
AU  - Wysowski, Diane K
AU  - Nourjah, Parivash
AU  - Swartz, Lynette
AD  - Division of Drug Risk Evaluation, Food and Drug Administration, White Oak, Bldg 22, Room 3424, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. diane.wysowski@fda.hhs.gov
Y1  - 2007/07/09/
PY  - 2007
DA  - 2007 Jul 09
SP  - 1414
EP  - 1419
VL  - 167
IS  - 13
SN  - 0003-9926, 0003-9926
KW  - Anticoagulants
KW  - 0
KW  - Warfarin
KW  - 5Q7ZVV76EI
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - United States Food and Drug Administration
KW  - Drug and Narcotic Control
KW  - Humans
KW  - International Normalized Ratio
KW  - Death Certificates
KW  - United States -- epidemiology
KW  - Cause of Death
KW  - Drug Prescriptions -- statistics & numerical data
KW  - Hemorrhage -- epidemiology
KW  - Hemorrhage -- chemically induced
KW  - Anticoagulants -- adverse effects
KW  - Warfarin -- adverse effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Bleeding+complications+with+warfarin+use%3A+a+prevalent+adverse+effect+resulting+in+regulatory+action.&rft.au=Wysowski%2C+Diane+K%3BNourjah%2C+Parivash%3BSwartz%2C+Lynette&rft.aulast=Wysowski&rft.aufirst=Diane&rft.date=2007-07-09&rft.volume=167&rft.issue=13&rft.spage=1414&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-17
N1  - Date created - 2007-07-10
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
Nat Clin Pract Cardiovasc Med. 2008 Jan;5(1):14-5 [17940514]
Arch Intern Med. 2008 Jan 28;168(2):236-7; author reply 237 [18227374]
N1  - Last updated - 2017-01-18
ER  - 



TY  - CPAPER
T1  - Produce Time Temperature Control for Safety Where Do Lettuce and Leafy Greens Fits?
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39542791; 4647959
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Bohm, Shirley B
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Temperature effects
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39542791?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Produce+Time+Temperature+Control+for+Safety+Where+Do+Lettuce+and+Leafy+Greens+Fits%3F&rft.au=Bohm%2C+Shirley+B&rft.aulast=Bohm&rft.aufirst=Shirley&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Cancer Risk Estimation Derived from Studies of Nuclear Workers.
T2  - 13th International Congress of Radiation Research (ICRR 2007)
AN  - 39496512; 4659301
JF  - 13th International Congress of Radiation Research (ICRR 2007)
AU  - Schubauer-Berigan, Mary K
AU  - Daniels, Robert D
AU  - Silver, Sharon R
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Cancer
KW  - U 2000:Biological Sciences
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L2  - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Ecological Problems in the Shallow Eutrophic Latvian Lakes
T2  - Fifth Symposium for European Freshwater Sciences (SEFS 5)
AN  - 39475756; 4677056
JF  - Fifth Symposium for European Freshwater Sciences (SEFS 5)
AU  - Balode, Maija
AU  - Barda, Ieva
AU  - Purina, Ingrida
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Eutrophication
KW  - Lakes
KW  - Eutrophic waters
KW  - U 2000:Biological Sciences
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L2  - http://www.sefs5.it/Programme_1.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Prevalence and Antimicrobial Resistance of Salmonella Isolated from Retail Meat: National Antimicrobial Resistance Monitoring System (NARMS): 20022005
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39472866; 4647972
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Zhao, Shaohua
AU  - White, D G
AU  - Hall-Robinson, E
AU  - Ayers, L
AU  - Glenn, A
AU  - Friedman, S L
AU  - Abbott, J W
AU  - Harbottle, H
AU  - McDermott, P F
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Antimicrobial agents
KW  - Antimicrobial resistance
KW  - Meat
KW  - Monitoring systems
KW  - Anadromous species
KW  - Salmonella
KW  - U 2000:Biological Sciences
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L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - A Model for Assessing the Training Needs of Retail Food Safety Inspection Officers
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39464624; 4647598
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Tart, Alan M
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Inspection
KW  - Training
KW  - Food
KW  - Models
KW  - Public health
KW  - U 2000:Biological Sciences
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=A+Model+for+Assessing+the+Training+Needs+of+Retail+Food+Safety+Inspection+Officers&rft.au=Tart%2C+Alan+M&rft.aulast=Tart&rft.aufirst=Alan&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Genetic Diversity of Salmonella enterica Serovar Weltevreden Isolates from Imported Seafood
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39462841; 4647555
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Ponce, Elizabeth
AU  - Khan, Ashaf
AU  - Cheng, Chorng-Ming
AU  - Summage, Christine
AU  - Cerniglia, Carl E
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Seafood
KW  - Genetic diversity
KW  - Anadromous species
KW  - Salmonella enterica
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39462841?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Genetic+Diversity+of+Salmonella+enterica+Serovar+Weltevreden+Isolates+from+Imported+Seafood&rft.au=Ponce%2C+Elizabeth%3BKhan%2C+Ashaf%3BCheng%2C+Chorng-Ming%3BSummage%2C+Christine%3BCerniglia%2C+Carl+E&rft.aulast=Ponce&rft.aufirst=Elizabeth&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Recovery of Staphylococcal Enterotoxin in Multiple Phase Foods
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39456055; 4647949
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Bennett, Reginald W
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Food
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39456055?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Emergence+of+a+Virulent+Clade+of+Vibrio+vulnificus+and+Correlation+with+the+Presence+of+a+33-Kilobase+Genomic+Island&rft.au=Cohen%2C+Ana+Luisa+V%3BOliver%2C+James+D%3BDePaola%2C+Angelo%3BFeil%2C+Edward+J%3BFidelma+Boyd%2C+E&rft.aulast=Cohen&rft.aufirst=Ana+Luisa&rft.date=2007-09-01&rft.volume=73&rft.issue=17&rft.spage=5553&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Efficiency of Transport Media for Recovery of Listeria from Milk Biofilm and Meat Processing Plant Environmental Swabs
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39455633; 4647822
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Reineke, Karl
AU  - Stewart, Diana
AU  - Tortorello, Mary Lou
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Milk
KW  - Biofilms
KW  - Meat
KW  - Media (transport)
KW  - Listeria
KW  - U 2000:Biological Sciences
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L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
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DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Identification and Molecular Characterization of Class 1 Integron Resistance Genes Cassettes among Salmonella Strains from Imported Seafood
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39454607; 4647998
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Khan, Ashaf A
AU  - Cheng, Chorng-Ming
AU  - Ponce, Elizabeth
AU  - Khan, Junaid A
AU  - West, Christine S
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Seafood
KW  - Anadromous species
KW  - Strains
KW  - Salmonella
KW  - U 2000:Biological Sciences
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L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Effect of Heat Treatment on the Quantitation of Peanut Allergens by ELISA Test Kits
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39451609; 4647941
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Fu, Tong-Jen
AU  - Maks, Nicole
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Allergens
KW  - ELISA
KW  - Heat treatments
KW  - Nuts
KW  - Quantitation
KW  - Arachis hypogaea
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39451609?accountid=14244
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L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Food Allergy Regulatory Update
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39450323; 4647729
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Harden, Elizabeth L
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Food hypersensitivity
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39450323?accountid=14244
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L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Effect of the Combination of pH, Water Activity and Temperature on the Growth of Bacillus anthracis
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39449748; 4647981
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Hao, Yun-Yun D
AU  - Whiting, Richard C
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Temperature effects
KW  - PH
KW  - PH effects
KW  - Water temperature
KW  - Water activity
KW  - Abiotic factors
KW  - Growth
KW  - Bacillus anthracis
KW  - U 2000:Biological Sciences
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Other May 2007 Critical Decisions
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39440529; 4647624
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Sims, Steven
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Milk
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39440529?accountid=14244
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L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Microarrays for Analysis and Detection of Microbial Pathogens and Their Toxins
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39440242; 4647962
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Rasooly, Avraham
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Pathogens
KW  - Toxins
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39440242?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Microarrays+for+Analysis+and+Detection+of+Microbial+Pathogens+and+Their+Toxins&rft.au=Rasooly%2C+Avraham&rft.aulast=Rasooly&rft.aufirst=Avraham&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - A Safety Strategic Plan to Open Estuary
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39437121; 4647738
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Depaola, Angelo
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Estuaries
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39437121?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=A+Safety+Strategic+Plan+to+Open+Estuary&rft.au=Depaola%2C+Angelo&rft.aulast=Depaola&rft.aufirst=Angelo&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Asian Traditional Food Safety Case Study Georgia
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39432780; 4647851
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Livsey, Kimberly
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - USA, Georgia
KW  - Case studies
KW  - Food
KW  - Public health
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39432780?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Asian+Traditional+Food+Safety+Case+Study+Georgia&rft.au=Livsey%2C+Kimberly&rft.aulast=Livsey&rft.aufirst=Kimberly&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Developing Risk Profiles to Assist Regulatory Decision Making
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39429227; 4648067
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Miliotis, Marianne
AU  - Dennis, Sherri
AU  - Buchanan, Robert
AU  - Hicks, John
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Decision making
KW  - Risk factors
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39429227?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Developing+Risk+Profiles+to+Assist+Regulatory+Decision+Making&rft.au=Miliotis%2C+Marianne%3BDennis%2C+Sherri%3BBuchanan%2C+Robert%3BHicks%2C+John&rft.aulast=Miliotis&rft.aufirst=Marianne&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - FDAs Use of Epidemiologic Data, Traceback Investigations and Farm Investigations as Regulatory Tools during Outbreaks of Cyclospora cayetanensis Associated with Produce, 19952005
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39428333; 4647756
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Timbo, Babgaleh B
AU  - Ross, Marianne P
AU  - Street, Debra A
AU  - Guzewich, Jack J
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Farms
KW  - Outbreaks
KW  - FDA
KW  - Cyclospora cayetanensis
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39428333?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=FDAs+Use+of+Epidemiologic+Data%2C+Traceback+Investigations+and+Farm+Investigations+as+Regulatory+Tools+during+Outbreaks+of+Cyclospora+cayetanensis+Associated+with+Produce%2C+19952005&rft.au=Timbo%2C+Babgaleh+B%3BRoss%2C+Marianne+P%3BStreet%2C+Debra+A%3BGuzewich%2C+Jack+J&rft.aulast=Timbo&rft.aufirst=Babgaleh&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Survival of Bacillus anthracis Vegetative Cells in Beverages
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39404943; 4647887
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Hao, Yun-Yun D
AU  - Whiting, Richard C
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Survival
KW  - Vegetative cells
KW  - Beverages
KW  - Cell survival
KW  - Bacillus anthracis
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39404943?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Survival+of+Bacillus+anthracis+Vegetative+Cells+in+Beverages&rft.au=Hao%2C+Yun-Yun+D%3BWhiting%2C+Richard+C&rft.aulast=Hao&rft.aufirst=Yun-Yun&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Comparison of Real-time PCR with Conventional Culture for Detection of Yersinia enterocolitica in Environmental Swabs
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39404686; 4647802
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Stewart, Diana
AU  - Laird, David
AU  - Reineke, Karl
AU  - Tortorello, Mary Lou
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Polymerase chain reaction
KW  - Nucleotide sequence
KW  - Yersinia enterocolitica
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39404686?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ciencia+%26+saude+coletiva&rft.atitle=Ethical+and+scientific+issues+of+nanotechnology+in+the+workplace.&rft.au=Schulte%2C+Paul+A%3BSalamanca-Buentello%2C+Fabio&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2007-09-01&rft.volume=12&rft.issue=5&rft.spage=1319&rft.isbn=&rft.btitle=&rft.title=Ciencia+%26+saude+coletiva&rft.issn=1678-4561&rft_id=info:doi/
L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Simultaneous Determination of Three Macrolide Antibiotics in Foodstuffs by High-performance Liquid Chromatography
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39361608; 4647945
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Kim, Su-Ok
AU  - Bhan, K N
AU  - Lee, S H
AU  - Won, S Y
AU  - Lee, H J
AU  - Park, S W
AU  - Ok, H M
AU  - Kang, H I
AU  - Kim, S H
AU  - Kim, D B
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Antibiotics
KW  - Liquid chromatography
KW  - High-performance liquid chromatography
KW  - Food
KW  - Macrolide antibiotics
KW  - U 2000:Biological Sciences
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39361608?accountid=14244
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L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Managing an Outbreak Investigation: The Role of an Enforcement Officer: Two Perspectives
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39361381; 4647847
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Bohm, Shirley B
AU  - Sprenger, Richard
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Outbreaks
KW  - U 2000:Biological Sciences
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L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Universal M13 Tailed Primers for Use in Sequencing PCR Products with Degenerative Primers or Short Amplicons
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39361294; 4647797
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Woods, Jacquelina W
AU  - Gonzalez-Escalona, Narjol
AU  - Burkhardt III, William
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Primers
KW  - Polymerase chain reaction
KW  - Nucleotide sequence
KW  - U 2000:Biological Sciences
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L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - CPAPER
T1  - Environmental Investigation of Carrot Juice Processor and Regulatory Response
T2  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AN  - 39352499; 4647501
JF  - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007)
AU  - Zink, Donald
Y1  - 2007/07/08/
PY  - 2007
DA  - 2007 Jul 08
KW  - Juices
KW  - Daucus
KW  - U 2000:Biological Sciences
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L2  - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-12-18
N1  - Last updated - 2010-05-03
ER  - 



TY  - JOUR
T1  - Developmental regression and autism reported to the Vaccine Adverse Event Reporting System.
AN  - 85395444; pmid-17656395
AB  - We report demographic and clinical characteristics of children reported to the US Vaccine Adverse Event Reporting System (VAERS) as having autism or another developmental disorder after vaccination. We completed 124 interviews with parents and reviewed medical records for 31 children whose records contained sufficient information to evaluate the child's developmental history. Medical record review indicated that 27 of 31 (87%) children had autism/ASD and 19 (61.3%) had evidence of developmental regression (loss of social, language, or motor skills). The proportion of VAERS cases of autism with regression was greater than that reported in population-based studies, based on the subset of VAERS cases with medical record confirmation. This difference may reflect preferential reporting to VAERS of autism with regression. In other respects, the children in this study appear to be similar to other children with autism. Further research might determine whether the pathogenesis of autism with developmental regression differs from that of autism without regression.
JF  - Autism : the international journal of research and practice
AU  - Woo, Emily Jane
AU  - Ball, Robert
AU  - Landa, Rebecca
AU  - Zimmerman, Andrew W
AU  - Braun, M Miles
AD  - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. jane.woo@fda.hhs.gov
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 301
EP  - 310
VL  - 11
IS  - 4
SN  - 1362-3613, 1362-3613
KW  - Index Medicus
KW  - National Library of Medicine
KW  - *Adverse Drug Reaction Reporting Systems: statistics & numerical data
KW  - Autistic Disorder: diagnosis
KW  - *Autistic Disorder: epidemiology
KW  - Comorbidity
KW  - Databases, Factual: statistics & numerical data
KW  - Developmental Disabilities: diagnosis
KW  - *Developmental Disabilities: epidemiology
KW  - Female
KW  - Humans
KW  - Infant
KW  - Interviews as Topic
KW  - Male
KW  - Parents
KW  - United States: epidemiology
KW  - *Vaccines: adverse effects
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LA  - English (eng)
DB  - ComDisDome
N1  - Date revised - 2011-12-15
N1  - Last updated - 2012-07-13
ER  - 



TY  - JOUR
T1  - The dependence of time-domain speed-of-sound measurements on center frequency, bandwidth, and transit-time marker in human calcaneus in vitro.
AN  - 742772857; pmid-17614520
AB  - Time-domain speed-of-sound (SOS) measurements in calcaneus are effective predictors of osteoporotic fracture risk. High attenuation and dispersion in bone, however, produce severe distortion of transmitted pulses that leads to ambiguity of time-domain SOS measurements. An equation to predict the effects of system parameters (center frequency and bandwidth), algorithm parameters (pulse arrival-time marker), and bone properties (attenuation coefficient and thickness) on time-domain SOS estimates is derived for media with attenuation that varies linearly with frequency. The equation is validated using data from a bone-mimicking phantom and from 30 human calcaneus samples in vitro. The data suggest that the effects of dispersion are small compared with the effects of frequency-dependent attenuation. The equation can be used to retroactively compensate data. System-related variations in SOS are shown to decrease as the pulse-arrival-time marker is moved toward the pulse center. Therefore, compared with other time-domain measures of SOS, group velocity exhibits the minimum system dependence.
JF  - The Journal of the Acoustical Society of America
AU  - Wear, Keith A
AD  - U.S. Food and Drug Administration, Center for Devices and Radiological Health, HFZ-140, Rockville, Maryland 20852, USA. kaw@cdrh.fda.gov
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 636
EP  - 644
VL  - 122
IS  - 1
SN  - 0001-4966, 0001-4966
KW  - Index Medicus
KW  - National Library of Medicine
KW  - Osteoporosis -- diagnosis
KW  - Computer Simulation
KW  - Reproducibility of Results
KW  - Ultrasonography -- instrumentation
KW  - Humans
KW  - Fractures, Bone -- etiology
KW  - Algorithms
KW  - Time Factors
KW  - Models, Biological
KW  - Male
KW  - Female
KW  - Osteoporosis -- complications
KW  - Phantoms, Imaging
KW  - Artifacts
KW  - Calcaneus -- ultrasonography
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LA  - English (eng)
DB  - ComDisDome
N1  - Date revised - 2010-04-13
N1  - Last updated - 2010-09-25
ER  - 



TY  - JOUR
T1  - Lack of evidence for contact sensitization by Pfiesteria extract.
AN  - 70726704; 17637917
AB  - Members of the estuarine dinoflagellate genus Pfiesteria are reported to have been responsible for massive fish kills in the southeastern United States. Some reports suggest that exposure to waters having Pfiesteria blooms or occupation-related exposure might result in Pfiesteria-induced dermal irritation and inflammation. Although the toxin has not been isolated and purified, the original data suggested both hydrophilic and hydrophobic toxic components. Some investigators propose that dermonecrotic properties are associated with a hydrophobic fraction.
          A bioactive C18-bound putative toxin (CPE) extracted from Pfiesteria-laden aquarium water during active fish-killing conditions was examined in the present study to evaluate its potential to produce inflammation and dermal sensitization and to determine whether the inflammation and dermatitis reported in early human exposure studies were allergic or irritant in nature. This fraction was cytotoxic to mouse Neuro-2A cells and primary human epidermal keratinocytes (NHEK) at a concentration of 1 mg/mL. Balb/C mice exposed to 50-200% CPE by skin painting exhibited a 6-10% increase in ear swelling relative to vehicle-treated mice in a primary irritancy assay. There was no increase in lymph node cell proliferation as measured using the local lymph node assay. Exposure to CPE in culture up-regulated interleukin-8 in NHEK, whereas granulocyte macrophage-colony-stimulating factor and tumor necrosis factor alpha were only minimally altered. This study suggests that CPE is cytotoxic to keratinocytes in culture at high concentrations and that it induces mild, localized irritation but not dermal sensitization.
JF  - Environmental health perspectives
AU  - Patterson, Rachel M
AU  - Noga, Edward
AU  - Germolec, Dori
AD  - Toxicology Operations Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 1023
EP  - 1028
VL  - 115
IS  - 7
SN  - 0091-6765, 0091-6765
KW  - Index Medicus
KW  - Animals
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Female
KW  - Cell Line
KW  - Pfiesteria piscicida -- immunology
KW  - Dermatitis, Contact
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-14
N1  - Date created - 2007-07-19
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Toxicology. 2000 Jan 17;142(3):203-11 [10667891]
Environ Health Perspect. 2006 Jul;114(7):1038-43 [16835056]
J Toxicol Environ Health A. 2001 Aug 24;63(8):553-64 [11549115]
Environ Health Perspect. 2001 Oct;109 Suppl 5:731-7 [11677182]
Environ Health Perspect. 2001 Oct;109 Suppl 5:739-43 [11677183]
Environ Health Perspect. 2001 Oct;109 Suppl 5:745-56 [11677184]
Environ Health Perspect. 2001 Oct;109 Suppl 5:781-6 [11677189]
Environ Health Perspect. 2001 Oct;109 Suppl 5:639-59 [11687383]
Regul Toxicol Pharmacol. 2001 Dec;34(3):258-73 [11754530]
Neurotoxicol Teratol. 2001 Nov-Dec;23(6):609-16 [11792529]
Clin Exp Dermatol. 2002 Mar;27(2):138-46 [11952708]
South Med J. 2002 Jul;95(7):720-6 [12144078]
Food Chem Toxicol. 2002 Nov;40(11):1719-25 [12176099]
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):10970-5 [12163648]
Nature. 2002 Aug 29;418(6901):967-70 [12198545]
Environ Health Perspect. 2002 Oct;110 Suppl 5:761-6 [12426128]
Neurotoxicol Teratol. 2003 Jul-Aug;25(4):419-26 [12798959]
Toxicol In Vitro. 2004 Jun;18(3):231-43 [15046769]
Nature. 1992 Jul 30;358(6385):407-10 [1641022]
J Toxicol Environ Health. 1995 Dec;46(4):501-22 [8523474]
Md Med J. 1997 Nov-Dec;46(10):521-3 [9392940]
Environ Health Perspect. 1997 Dec;105(12):1320-5 [9405328]
Md Med J. 1998 Feb-Mar;47(2):64-6 [9524412]
Md Med J. 1998 May;47(3):124-6 [9601197]
Md Med J. 1998 May;47(3):137-43 [9601201]
Lancet. 1998 Aug 15;352(9127):532-9 [9716058]
Sci Am. 1999 Aug;281(2):42-9 [10443037]
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Appl Environ Microbiol. 2005 Jan;71(1):519-29 [15640229]
Neurotoxicol Teratol. 2005 Sep-Oct;27(5):701-10 [16198085]
J Immunol. 2000 Mar 15;164(6):3392-401 [10706735]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China.
AN  - 70725176; 17637929
AB  - Because metallothionein (MT) is a metal-binding protein that protects against metal intoxication, it could be a biomarker for individual sensitivity to metal toxicity.
          We assessed the use of bloodborne MT transcript as a reflection of tissue MT levels and examined the potential role of MT in arsenic toxicity in an environmentally exposed human population. Rodents were treated with zinc or nonmetallic MT inducers for 4 days, and the blood and tissues were collected for MT transcript analysis by real-time reverse transcriptase-polymerase chain reaction and MT protein determination by the cadmium-hemoglobin assay. Blood and buccal cell samples were collected from arsenicosis patients and healthy subjects residing in Guizhou, China, and total RNA was isolated for MT transcript analysis.
          There was a positive correlation between blood MT-1 and MT-2 transcripts and corresponding hepatic or renal MT transcript levels in rats and mice. Furthermore, there was a positive correlation between blood MT-1 and MT-2 transcript and tissue MT protein levels in these animals. A positive correlation also occurred between human blood MT and buccal cell MT transcript levels. MT-1A and MT-2A were the major isoform transcripts in human blood and buccal cells, and significantly lower MT levels were seen in arsenicosis patients compared with healthy subjects. Blood MT transcript appears to be a useful biomarker of tissue MT levels. Arsenicosis patients in Guizhou show significantly lower MT transcript levels in blood, which may have predisposed this population to arsenic intoxication.
JF  - Environmental health perspectives
AU  - Liu, Jie
AU  - Cheng, Min-Liang
AU  - Yang, Qin
AU  - Shan, Ke-Ren
AU  - Shen, Jun
AU  - Zhou, Yushu
AU  - Zhang, Xinjiang
AU  - Dill, Anna L
AU  - Waalkes, Michael P
AD  - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA.
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 1101
EP  - 1106
VL  - 115
IS  - 7
SN  - 0091-6765, 0091-6765
KW  - Biomarkers
KW  - 0
KW  - DNA Primers
KW  - RNA, Messenger
KW  - Metallothionein
KW  - 9038-94-2
KW  - Arsenic
KW  - N712M78A8G
KW  - Index Medicus
KW  - Rats
KW  - Polymerase Chain Reaction
KW  - Animals
KW  - Rats, Inbred F344
KW  - Base Sequence
KW  - Humans
KW  - Male
KW  - Female
KW  - China
KW  - Arsenic -- toxicity
KW  - RNA, Messenger -- blood
KW  - Metallothionein -- genetics
KW  - Biomarkers -- blood
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-14
N1  - Date created - 2007-07-19
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
J Toxicol Environ Health A. 1999 Nov 12;58(5):313-27 [10598956]
Toxicol Appl Pharmacol. 1985 Mar 30;78(1):63-8 [4035673]
Toxicol Sci. 2000 Jun;55(2):460-7 [10828279]
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Toxicol Sci. 2001 Jan;59(1):185-92 [11134558]
Br J Nutr. 2000 Nov;84(5):747-56 [11177190]
Toxicology. 2001 Jun 21;163(2-3):93-100 [11516518]
J Toxicol Environ Health A. 2001 Nov 23;64(6):473-84 [11732698]
J Prev Soc Med. 1999 Jun;18(1):35-40 [12179653]
Environ Health Perspect. 2002 Feb;110(2):119-22 [11836136]
J Biochem. 2002 Aug;132(2):217-21 [12153718]
Environ Health Perspect. 2002 Oct;110 Suppl 5:827-30 [12426140]
Carcinogenesis. 2003 Jan;24(1):25-9 [12538345]
Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 [12583988]
Int J Cancer. 2003 May 10;104(6):735-44 [12640681]
Mutat Res. 2003 Dec 10;533(1-2):201-9 [14643421]
Pathol Oncol Res. 2004;10(2):74-9 [15188022]
Toxicol Sci. 2004 Jul;80(1):69-73 [15071173]
Int J Oncol. 2004 Aug;25(2):325-33 [15254729]
Yale J Biol Med. 2003;76(2):55-62 [15369632]
Cell. 1981 Jul;25(1):233-40 [6168387]
Toxicology. 1986 Mar;38(3):261-8 [3952754]
Experientia Suppl. 1987;52:519-23 [2959543]
Int Arch Occup Environ Health. 1988;60(6):413-7 [3410551]
Methods Enzymol. 1991;205:613-26 [1779825]
Arch Neurol. 1992 Jul;49(7):721-4 [1497498]
Chem Biol Interact. 1992 Dec;85(2-3):127-40 [1493605]
Fundam Appl Toxicol. 1993 Feb;20(2):184-9 [8449390]
Biochemistry. 1994 Jun 14;33(23):7250-9 [8003488]
J Pharmacol Exp Ther. 1996 May;277(2):1026-33 [8627513]
Cancer Chemother Pharmacol. 1997;40(4):358-62 [9225956]
Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085]
Cancer Res. 2004 Nov 1;64(21):7766-72 [15520181]
Toxicol Lett. 2005 Feb 15;155(2):319-27 [15603927]
Toxicol Sci. 2005 Feb;83(2):372-9 [15509664]
Environ Health Perspect. 2006 Mar;114(3):404-11 [16507464]
Int J Cancer. 2006 Jul 1;119(1):28-32 [16432836]
Biomed Environ Sci. 2006 Apr;19(2):104-9 [16827180]
J Am Chem Soc. 2006 Sep 27;128(38):12473-83 [16984198]
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Toxicol Appl Pharmacol. 1982 Oct;66(1):134-42 [7157381]
Cell Mol Biol (Noisy-le-grand). 2000 Mar;46(2):419-33 [10774930]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Gene-air pollution interactions in asthma.
AN  - 70672060; 17607002
AB  - Genetic and environmental factors interact to cause asthma. However, genetic studies have generally ignored environmental factors and environmental studies have generally ignored genetics. Thus, there are few examples from the literature of specific gene-environment interactions in relation to asthma. The clearest examples of genetic interactions for inhaled pollutants exist for endotoxin, environmental tobacco smoke, and ozone. Endotoxin-genetic interactions in asthma are the focus of two other manuscripts from this conference, so this review focuses on environmental tobacco smoke and ozone. In the sparse literature, there is evidence for the role of specific genes involved in oxidative stress, notably GSTM1 and TNF, in the respiratory responses to ozone and environmental tobacco smoke. There are few data on genes involved in innate immune pathways, which are crucial in response to endotoxin and may play a role in response to ozone and environmental tobacco smoke. Genes involved in oxidative stress may interact with both air pollutants and diet in relation to asthma phenotypes. Future directions to advance the field include whole genome association studies, better assessment of exposure and phenotypes, and consideration of joint interactions with diet and other co-factors that influence individual susceptibility.
JF  - Proceedings of the American Thoracic Society
AU  - London, Stephanie J
AD  - Epidemiology Branch and Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. London2@niehs.nih.gov
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 217
EP  - 220
VL  - 4
IS  - 3
SN  - 1546-3222, 1546-3222
KW  - Tobacco Smoke Pollution
KW  - 0
KW  - Tumor Necrosis Factor-alpha
KW  - Ozone
KW  - 66H7ZZK23N
KW  - GSTP1 protein, human
KW  - EC 2.5.1.18
KW  - Glutathione S-Transferase pi
KW  - Glutathione Transferase
KW  - glutathione S-transferase M1
KW  - Index Medicus
KW  - Phenotype
KW  - Glutathione S-Transferase pi -- genetics
KW  - Genotype
KW  - Polymorphism, Genetic
KW  - Humans
KW  - Glutathione Transferase -- genetics
KW  - Genetic Predisposition to Disease
KW  - Tumor Necrosis Factor-alpha -- genetics
KW  - Asthma -- genetics
KW  - Tobacco Smoke Pollution -- adverse effects
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70672060?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+American+Thoracic+Society&rft.atitle=Gene-air+pollution+interactions+in+asthma.&rft.au=London%2C+Stephanie+J&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2007-07-01&rft.volume=4&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+American+Thoracic+Society&rft.issn=15463222&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-18
N1  - Date created - 2007-07-03
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Am J Respir Crit Care Med. 2001 May;163(6):1426-31 [11371413]
Am J Respir Crit Care Med. 2006 Dec 15;174(12):1335-41 [17023730]
Am J Respir Crit Care Med. 2002 Aug 15;166(4):457-63 [12186820]
Toxicol Lett. 2002 Aug 5;134(1-3):219-25 [12191881]
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J Allergy Clin Immunol. 2003 Apr;111(4):840-6 [12704367]
JAMA. 2003 Oct 8;290(14):1859-67 [14532314]
JAMA. 2003 Oct 8;290(14):1915-7 [14532321]
Am J Respir Crit Care Med. 2003 Nov 15;168(10):1199-204 [12969868]
Thorax. 2004 Jan;59(1):8-10 [14694237]
Thorax. 2004 Apr;59(4):295-302 [15047948]
Am J Respir Cell Mol Biol. 2004 Jul;31(1):69-77 [14975936]
Am J Respir Crit Care Med. 2004 Jul 15;170(2):126-32 [15020293]
Am J Respir Crit Care Med. 2004 Aug 1;170(3):279-87 [15117740]
Pharmacogenetics. 1991 Nov;1(2):110-3 [1844868]
Am J Respir Crit Care Med. 1996 Jan;153(1):3-50 [8542133]
Environ Health Perspect. 2007 Apr;115(4):616-22 [17450233]
Nat Genet. 1997 Dec;17(4):471-4 [9398853] Nat Genet. 1997 Dec;17(4):475-8 [9398854]
Am J Respir Crit Care Med. 1998 Jul;158(1):226-32 [9655734]
Am J Respir Crit Care Med. 2005 Jan 15;171(2):171-6 [15486341]
J Allergy Clin Immunol. 2005 Jun;115(6):1169-75 [15940130]
Am J Respir Crit Care Med. 2005 Jul 15;172(2):173-82 [15879416]
Thorax. 2005 Dec;60(12):1052-8 [16131525]
Am J Respir Crit Care Med. 2005 Dec 15;172(12):1563-8 [16166621]
Am J Respir Crit Care Med. 2006 Feb 1;173(3):264-70 [16239624]
Genes Immun. 2006 Mar;7(2):95-100 [16395390]
Environ Health Perspect. 2006 Apr;114(4):627-33 [16581557]
Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L931-45 [16361358]
Am J Respir Crit Care Med. 2006 May 1;173(9):970-6 [16456144]
Pediatrics. 2006 Aug;118(2):710-6 [16882827]
Lancet. 2006 Aug 26;368(9537):733-43 [16935684]
Eur Respir J. 2006 Nov;28(5):953-9 [16870661]
Epidemiology. 2001 Sep;12(5):577-83 [11505179]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Preeclampsia risk in women exposed in utero to diethylstilbestrol.
AN  - 70667429; 17601905
AB  - To assess whether preeclampsia risk is elevated in pregnancies of diethylstilbestrol (DES)-exposed daughters.
          This study used data from the National Cancer Institute DES Combined Cohorts Follow-up Study. A total of 285 preeclampsia cases (210 exposed and 75 unexposed) occurred in 7,313 live births (4,759 DES exposed and 2,554 unexposed). Poisson regression analysis estimated relative risks and 95% confidence intervals (CI) for preeclampsia adjusted for age at the index pregnancy, parity, education, smoking, body mass index, year of diagnosis, and cohort. In utero DES exposure was associated with nearly a 50% elevation in preeclampsia risk. Adjustment for preeclampsia risk factors attenuated the relative risk slightly (1.42, 95% CI 1.04-1.94). The excess risk with DES was concentrated among women who developed preeclampsia in their first pregnancies (relative risk 1.81, 95% CI 1.17-2.79), who were exposed before 15 weeks of gestation (relative risk 1.57, 95% CI 1.11-2.23), and who were treated with magnesium sulfate (relative risk 2.10, 95% CI 0.82-5.42). Among DES-exposed women who had a prior hysterosalpingogram, preeclampsia prevalence was higher in those with uterine abnormalities (12.4%) than in those without (7.7%).
          These data suggest that in utero exposure to DES is associated with a slightly elevated risk of preeclampsia, and that one possible biological mechanism involves uterine abnormalities.
JF  - Obstetrics and gynecology
AU  - Troisi, Rebecca
AU  - Titus-Ernstoff, Linda
AU  - Hyer, Marianne
AU  - Hatch, Elizabeth E
AU  - Robboy, Stanley J
AU  - Strohsnitter, William
AU  - Palmer, Julie R
AU  - Øglaend, Bjørn
AU  - Adam, Ervin
AU  - Kaufman, Raymond
AU  - Herbst, Arthur L
AU  - Hoover, Robert N
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. troisir@mail.nih.gov
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 113
EP  - 120
VL  - 110
IS  - 1
SN  - 0029-7844, 0029-7844
KW  - Estrogens, Non-Steroidal
KW  - 0
KW  - Diethylstilbestrol
KW  - 731DCA35BT
KW  - Abridged Index Medicus
KW  - Index Medicus
KW  - Risk Factors
KW  - Humans
KW  - Health Surveys
KW  - Cohort Studies
KW  - Adult
KW  - Uterus -- abnormalities
KW  - Follow-Up Studies
KW  - Uterus -- drug effects
KW  - Female
KW  - Proportional Hazards Models
KW  - Pregnancy
KW  - Diethylstilbestrol -- adverse effects
KW  - Pre-Eclampsia -- epidemiology
KW  - Pre-Eclampsia -- chemically induced
KW  - Estrogens, Non-Steroidal -- adverse effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Preeclampsia+risk+in+women+exposed+in+utero+to+diethylstilbestrol.&rft.au=Troisi%2C+Rebecca%3BTitus-Ernstoff%2C+Linda%3BHyer%2C+Marianne%3BHatch%2C+Elizabeth+E%3BRobboy%2C+Stanley+J%3BStrohsnitter%2C+William%3BPalmer%2C+Julie+R%3B%C3%98glaend%2C+Bj%C3%B8rn%3BAdam%2C+Ervin%3BKaufman%2C+Raymond%3BHerbst%2C+Arthur+L%3BHoover%2C+Robert+N&rft.aulast=Troisi&rft.aufirst=Rebecca&rft.date=2007-07-01&rft.volume=110&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-07-31
N1  - Date created - 2007-07-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The epidemiology of DSM-IV specific phobia in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
AN  - 70658413; 17335637
AB  - There is a lack of current detailed national data on the prevalence, correlates, disability and co-morbidity of DSM-IV specific phobia (SP), the prevalence of specific objects and situations feared, and associations between impairment, treatment and co-morbidity and the number of specific situations and objects feared, among adults in the USA.
          The data were derived from a large (43093) representative sample of the adult population in the USA. Prevalences of 12-month and lifetime DSM-IV SP were 7.1% and 9.4% respectively. Being female, young, and low income increased risk, while being Asian or Hispanic decreased risk (p<0.05). The mean age at onset of SP was 9.7 years, the mean duration of episode was 20.1 years and only 8.0% reported treatment specifically for SP. Most specific phobias involved multiple fears, and an increasing number of fears, regardless of content, was associated with greater disability and impairment, treatment seeking and co-morbidity with other Axis I and II disorders.
          SP is a highly prevalent, disabling and co-morbid disorder in the US adult population. The early onset of SP and the disorders most strongly associated with it highlights the need for longitudinal studies beginning in early childhood. Results suggest the existence of a generalized subtype of SP much like social phobia, which, once revealed, may lead to a classification of SP that is more etiologically and therapeutically meaningful.
JF  - Psychological medicine
AU  - Stinson, Frederick S
AU  - Dawson, Deborah A
AU  - Patricia Chou, S
AU  - Smith, Sharon
AU  - Goldstein, Rise B
AU  - June Ruan, W
AU  - Grant, Bridget F
AD  - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA.
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 1047
EP  - 1059
VL  - 37
IS  - 7
SN  - 0033-2917, 0033-2917
KW  - Index Medicus
KW  - Age Factors
KW  - Sex Factors
KW  - Age of Onset
KW  - Humans
KW  - Aged
KW  - Comorbidity
KW  - Psychiatric Status Rating Scales
KW  - Adult
KW  - Health Surveys
KW  - Middle Aged
KW  - Adolescent
KW  - United States -- epidemiology
KW  - Female
KW  - Male
KW  - Prevalence
KW  - Phobic Disorders -- therapy
KW  - Phobic Disorders -- epidemiology
KW  - Phobic Disorders -- diagnosis
KW  - Diagnostic and Statistical Manual of Mental Disorders
KW  - Alcohol-Related Disorders -- epidemiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-29
N1  - Date created - 2007-06-25
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - A polyomic approach to elucidate the fluoranthene-degradative pathway in Mycobacterium vanbaalenii PYR-1.
AN  - 70628075; 17449607
AB  - Mycobacterium vanbaalenii PYR-1 is capable of degrading a wide range of high-molecular-weight polycyclic aromatic hydrocarbons (PAHs), including fluoranthene. We used a combination of metabolomic, genomic, and proteomic technologies to investigate fluoranthene degradation in this strain. Thirty-seven fluoranthene metabolites including potential isomers were isolated from the culture medium and analyzed by high-performance liquid chromatography, gas chromatography-mass spectrometry, and UV-visible absorption. Total proteins were separated by one-dimensional gel and analyzed by liquid chromatography-tandem mass spectrometry in conjunction with the M. vanbaalenii PYR-1 genome sequence (http://jgi.doe.gov), which resulted in the identification of 1,122 proteins. Among them, 53 enzymes were determined to be likely involved in fluoranthene degradation. We integrated the metabolic information with the genomic and proteomic results and proposed pathways for the degradation of fluoranthene. According to our hypothesis, the oxidation of fluoranthene is initiated by dioxygenation at the C-1,2, C-2,3, and C-7,8 positions. The C-1,2 and C-2,3 dioxygenation routes degrade fluoranthene via fluorene-type metabolites, whereas the C-7,8 routes oxidize fluoranthene via acenaphthylene-type metabolites. The major site of dioxygenation is the C-2,3 dioxygenation route, which consists of 18 enzymatic steps via 9-fluorenone-1-carboxylic acid and phthalate with the initial ring-hydroxylating oxygenase, NidA3B3, oxidizing fluoranthene to fluoranthene cis-2,3-dihydrodiol. Nonspecific monooxygenation of fluoranthene with subsequent O methylation of dihydroxyfluoranthene also occurs as a detoxification reaction.
JF  - Journal of bacteriology
AU  - Kweon, Ohgew
AU  - Kim, Seong-Jae
AU  - Jones, Richard C
AU  - Freeman, James P
AU  - Adjei, Michael D
AU  - Edmondson, Ricky D
AU  - Cerniglia, Carl E
AD  - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 4635
EP  - 4647
VL  - 189
IS  - 13
SN  - 0021-9193, 0021-9193
KW  - Acyl Coenzyme A
KW  - 0
KW  - Bacterial Proteins
KW  - Fluorenes
KW  - Proteome
KW  - fluoranthene
KW  - 360UOL779Z
KW  - succinyl-coenzyme A
KW  - 604-98-8
KW  - Acetyl Coenzyme A
KW  - 72-89-9
KW  - Index Medicus
KW  - Molecular Structure
KW  - Gene Expression Regulation, Bacterial
KW  - Genomics -- methods
KW  - Metabolic Networks and Pathways
KW  - Bacterial Proteins -- metabolism
KW  - Spectrophotometry, Ultraviolet
KW  - Models, Biological
KW  - Chromatography, High Pressure Liquid
KW  - Gene Order
KW  - Proteomics -- methods
KW  - Proteome -- metabolism
KW  - Bacterial Proteins -- analysis
KW  - Gas Chromatography-Mass Spectrometry
KW  - Biodegradation, Environmental
KW  - Acetyl Coenzyme A -- metabolism
KW  - Proteome -- analysis
KW  - Acyl Coenzyme A -- metabolism
KW  - Mycobacterium -- genetics
KW  - Fluorenes -- metabolism
KW  - Mycobacterium -- metabolism
KW  - Fluorenes -- chemistry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-10-04
N1  - Date created - 2007-06-20
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Carcinogenesis. 2004 Sep;25(9):1727-33 [15117810]
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Chem Res Toxicol. 1999 Jan;12(1):1-18 [9894013]
Microbiology. 2004 Nov;150(Pt 11):3749-61 [15528661]
Syst Appl Microbiol. 2004 Nov;27(6):653-60 [15612622]
J Ind Microbiol Biotechnol. 2004 Dec;31(11):507-16 [15549609]
Biodegradation. 2005 Dec;16(6):513-26 [15865344]
Microb Ecol. 2005 Jul;50(1):110-9 [16132428]
J Ind Microbiol Biotechnol. 2005 Oct;32(10):455-64 [16133098]
Appl Environ Microbiol. 2006 Feb;72(2):1045-54 [16461648]
Ecotoxicology. 2006 Mar;15(2):121-31 [16317483]
Nat Cell Biol. 2006 Apr;8(4):358-66 [16531994]
Appl Microbiol Biotechnol. 2006 May;70(6):747-56 [16133330]
Appl Microbiol Biotechnol. 2006 Jul;71(4):522-32 [16317545]
Crit Rev Biochem Mol Biol. 2006 Jul-Aug;41(4):241-67 [16849108]
Chemosphere. 2006 Oct;65(3):489-96 [16516947]
J Bacteriol. 2007 Jan;189(2):464-72 [17085566]
J Bacteriol. 2000 Apr;182(8):2059-67 [10735846]
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Eur J Biochem. 2001 May;268(9):2547-57 [11322873]
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Microbiology. 2001 Oct;147(Pt 10):2783-94 [11577157]
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Int J Syst Evol Microbiol. 2002 Nov;52(Pt 6):1997-2002 [12508859]
Eur J Biochem. 2003 Feb;270(3):486-94 [12542698]
Appl Environ Microbiol. 2003 Jul;69(7):3924-31 [12839762]
Arch Biochem Biophys. 2003 Aug 15;416(2):209-17 [12893299]
Int J Toxicol. 2003 Jul-Aug;22(4):263-76 [12933321]
BMC Bioinformatics. 2003 Sep 11;4:41 [12969510]
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Environ Toxicol Chem. 2003 Dec;22(12):2977-85 [14713039]
J Pharmacol Exp Ther. 2004 Feb;308(2):651-7 [14610244]
Anal Chem. 2004 Jul 15;76(14):4193-201 [15253663]
J Bacteriol. 2004 Sep;186(17):5938-44 [15317800]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies.
AN  - 70627209; 17431034
AB  - CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, to electrophilic reactive intermediates, leading to toxicity and cancer. CYP1As are highly inducible by PAHs and halogenated aromatic hydrocarbons via aryl hydrocarbon receptor-mediated gene transcription. The impact of CYP1A induction on the carcinogenic and toxic potentials of environmental, occupational, dietary, and therapeutic chemicals has been a central focus of human risk evaluation and has broadly influenced the fields of cancer research, toxicology, pharmacology, and risk assessment over the past half-century. From the early discovery of CYP1A induction and its role in protection against chemical carcinogenesis in intact animals, to the establishment of CYP1A enzymes as the principal cytochromes P450 for bioactivation of PAHs and HAAs in in vitro assays, to the recent realization of an essential protective role of CYP1A in benzo[a]pyrene-induced lethality and carcinogenesis with CYP1A knockout mice, the understanding of the interrelation between CYP1A induction and chemical safety has followed a full circle. This unique path of CYP1A research underscores the importance of whole animal and human studies in chemical safety evaluation.
JF  - Drug metabolism and disposition: the biological fate of chemicals
AU  - Ma, Qiang
AU  - Lu, Anthony Y H
AD  - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. qam1@cdc.gov
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 1009
EP  - 1016
VL  - 35
IS  - 7
SN  - 0090-9556, 0090-9556
KW  - Amines
KW  - 0
KW  - Anti-Ulcer Agents
KW  - Carcinogens
KW  - Heterocyclic Compounds
KW  - Polycyclic Aromatic Hydrocarbons
KW  - Receptors, Aryl Hydrocarbon
KW  - Benzo(a)pyrene
KW  - 3417WMA06D
KW  - Cytochrome P-450 CYP1A1
KW  - EC 1.14.14.1
KW  - Cytochrome P-450 CYP1A2
KW  - Omeprazole
KW  - KG60484QX9
KW  - Index Medicus
KW  - Receptors, Aryl Hydrocarbon -- drug effects
KW  - Polycyclic Aromatic Hydrocarbons -- toxicity
KW  - Animals
KW  - Drug Interactions
KW  - Anti-Ulcer Agents -- adverse effects
KW  - Omeprazole -- adverse effects
KW  - Humans
KW  - Mice
KW  - Gene Expression Regulation, Neoplastic -- drug effects
KW  - Risk Assessment
KW  - Mice, Knockout
KW  - Enzyme Induction -- drug effects
KW  - Biotransformation
KW  - Amines -- toxicity
KW  - Benzo(a)pyrene -- toxicity
KW  - Toxicity Tests -- methods
KW  - Heterocyclic Compounds -- toxicity
KW  - Receptors, Aryl Hydrocarbon -- metabolism
KW  - Cytochrome P-450 CYP1A1 -- genetics
KW  - Neoplasms -- enzymology
KW  - Carcinogens -- metabolism
KW  - Cytochrome P-450 CYP1A2 -- genetics
KW  - Cell Transformation, Neoplastic -- metabolism
KW  - Neoplasms -- chemically induced
KW  - Carcinogens -- toxicity
KW  - Cell Transformation, Neoplastic -- drug effects
KW  - Cytochrome P-450 CYP1A2 -- biosynthesis
KW  - Neoplasms -- genetics
KW  - Cytochrome P-450 CYP1A1 -- biosynthesis
KW  - Cell Transformation, Neoplastic -- genetics
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=CYP1A+induction+and+human+risk+assessment%3A+an+evolving+tale+of+in+vitro+and+in+vivo+studies.&rft.au=Ma%2C+Qiang%3BLu%2C+Anthony+Y+H&rft.aulast=Ma&rft.aufirst=Qiang&rft.date=2007-07-01&rft.volume=35&rft.issue=7&rft.spage=1009&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=00909556&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-07-24
N1  - Date created - 2007-06-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association.
AN  - 70623769; 17420218
AB  - Chromium (Cr) (VI) is a major environmental toxic metal and a human carcinogen. The molecular events mediating cellular responses to Cr(VI) are not clear at present. We show that Cr(VI) potently induced apoptosis and production of reactive oxygen species (ROS) in mouse hepa1c1c7 cells in a concentration-dependent manner. Mouse embryonic fibroblast cells lacking Nrf2 exhibited elevated ROS production and apoptosis, which were markedly further increased by Cr(VI), suggesting a protective role of Nrf2 against Cr(VI) toxicity. Protection by Nrf2 correlated with induction of cytoprotective genes Ho-1 and Nqo1. Induction of the genes by Cr(VI) involved inhibition of ubiquitination of Nrf2 and accumulation of Nrf2 into the nucleus. In the nucleus, treatment with Cr(VI), but not phenolic antioxidant tert-butylhydroquinone, librates Nrf2 from the Nrf2/Keap1 association and recruits Nrf2 to the antioxidant response elements (ARE) located in the enhancers of Ho-1 and Nqo1. Activation of Nrf2 by Cr(VI) was accompanied by the nuclear translocation and deubiquitination of Keap1 implicating recycling of Keap1 in Nrf2 signaling. Thus, protection against Cr(VI) toxicity involves a transcriptional signaling loop that includes activation of Nrf2 by the toxic metal, transcription of ARE-driven genes, and reduction of ROS production.
JF  - Toxicological sciences : an official journal of the Society of Toxicology
AU  - He, Xiaoqing
AU  - Lin, Gary X
AU  - Chen, Michael G
AU  - Zhang, Jennifer X
AU  - Ma, Qiang
AD  - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA.
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 298
EP  - 309
VL  - 98
IS  - 1
SN  - 1096-6080, 1096-6080
KW  - Adaptor Proteins, Signal Transducing
KW  - 0
KW  - Antioxidants
KW  - Chromatin
KW  - Cytoskeletal Proteins
KW  - Keap1 protein, mouse
KW  - Kelch-Like ECH-Associated Protein 1
KW  - NF-E2-Related Factor 2
KW  - Nfe2l2 protein, mouse
KW  - Chromium
KW  - 0R0008Q3JB
KW  - RNA
KW  - 63231-63-0
KW  - Cytochromes c
KW  - 9007-43-6
KW  - Heme Oxygenase-1
KW  - EC 1.14.14.18
KW  - Index Medicus
KW  - Animals
KW  - Blotting, Northern
KW  - Chromatin -- metabolism
KW  - Cytochromes c -- metabolism
KW  - Plasmids -- genetics
KW  - Immunoprecipitation
KW  - Mice
KW  - RNA -- biosynthesis
KW  - Cell Fractionation
KW  - Blotting, Western
KW  - Antioxidants -- pharmacology
KW  - Transfection
KW  - Heme Oxygenase-1 -- metabolism
KW  - Fluorescent Antibody Technique
KW  - RNA -- genetics
KW  - Adaptor Proteins, Signal Transducing -- physiology
KW  - Cell Nucleus -- metabolism
KW  - Cell Nucleus -- ultrastructure
KW  - NF-E2-Related Factor 2 -- physiology
KW  - NF-E2-Related Factor 2 -- genetics
KW  - NF-E2-Related Factor 2 -- antagonists & inhibitors
KW  - Cell Nucleus -- drug effects
KW  - Adaptor Proteins, Signal Transducing -- antagonists & inhibitors
KW  - Chromium -- toxicity
KW  - Chromium -- antagonists & inhibitors
KW  - Cytoskeletal Proteins -- physiology
KW  - Apoptosis -- drug effects
KW  - Cytoskeletal Proteins -- antagonists & inhibitors
KW  - Oxidative Stress -- drug effects
KW  - Adaptor Proteins, Signal Transducing -- genetics
KW  - Cytoskeletal Proteins -- genetics
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Protection+against+chromium+%28VI%29-induced+oxidative+stress+and+apoptosis+by+Nrf2.+Recruiting+Nrf2+into+the+nucleus+and+disrupting+the+nuclear+Nrf2%2FKeap1+association.&rft.au=He%2C+Xiaoqing%3BLin%2C+Gary+X%3BChen%2C+Michael+G%3BZhang%2C+Jennifer+X%3BMa%2C+Qiang&rft.aulast=He&rft.aufirst=Xiaoqing&rft.date=2007-07-01&rft.volume=98&rft.issue=1&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-06
N1  - Date created - 2007-06-15
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Smoking cigarettes before first childbirth and risk of breast cancer.
AN  - 70621877; 17426039
AB  - Inconsistent epidemiologic findings on cigarette smoking and female breast cancer risk may reflect insufficient assessment of smoking onset and amount relative to reproductive events. To determine the risk of breast cancer associated with smoking during different periods of reproductive life, the authors evaluated 906 incident breast cancer cases in a nationwide cohort of 56,042 female US radiologic technologists (1983-1998) who responded to two questionnaire surveys. After they accounted for age, birth cohort, and established breast cancer risk factors, smoking-related breast cancer risks differed by smoking during three reproductive time periods (p = 0.003), with a statistically significant 3% increase per pack-year of smoking between menarche and first childbirth (relative risk = 1.03, 95% confidence interval: 1.02, 1.05) and no significant association for smoking after first childbirth. Risk also increased with younger age at smoking initiation (p-trend = 0.06), after adjustment for pack-years of smoking before and after first childbirth, indicating an independent effect of age at smoking initiation. The findings from this study suggest that sensitivity of the female breast to tobacco carcinogens is increased during adolescence and early adulthood but decreases after first childbirth, when most breast tissue has terminally differentiated.
JF  - American journal of epidemiology
AU  - Ha, Mina
AU  - Mabuchi, Kiyohiko
AU  - Sigurdson, Alice J
AU  - Freedman, D Michal
AU  - Linet, Martha S
AU  - Doody, Michele Morin
AU  - Hauptmann, Michael
AD  - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. minaha@dankook.ac.kr
Y1  - 2007/07/01/
PY  - 2007
DA  - 2007 Jul 01
SP  - 55
EP  - 61
VL  - 166
IS  - 1
SN  - 0002-9262, 0002-9262
KW  - Index Medicus
KW  - Parity
KW  - Humans
KW  - Premenopause
KW  - Aged
KW  - Pregnancy
KW  - Postmenopause
KW  - Risk Factors
KW  - Adult
KW  - Health Surveys
KW  - Surveys and Questionnaires
KW  - Confidence Intervals
KW  - Incidence
KW  - Middle Aged
KW  - United States -- epidemiology
KW  - Female
KW  - Breast Neoplasms -- etiology
KW  - Smoking -- adverse effects
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Smoking+cigarettes+before+first+childbirth+and+risk+of+breast+cancer.&rft.au=Ha%2C+Mina%3BMabuchi%2C+Kiyohiko%3BSigurdson%2C+Alice+J%3BFreedman%2C+D+Michal%3BLinet%2C+Martha+S%3BDoody%2C+Michele+Morin%3BHauptmann%2C+Michael&rft.aulast=Ha&rft.aufirst=Mina&rft.date=2007-07-01&rft.volume=166&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-02
N1  - Date created - 2007-06-14
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Ketamine-induced neuronal cell death in the perinatal rhesus monkey.
AN  - 70620101; 17426105
AB  - Ketamine is widely used as a pediatric anesthetic. Studies in developing rodents have indicated that ketamine-induced anesthesia results in brain cell death. Additional studies are needed to determine if ketamine anesthesia results in brain cell death in the nonhuman primate and if so, to begin to define the stage of development and the duration of ketamine anesthesia necessary to produce brain cell death. Rhesus monkeys (N = 3 for each treatment and control group) at three stages of development (122 days of gestation and 5 and 35 postnatal days [PNDs]) were administered ketamine intravenously for 24 h to maintain a surgical anesthetic plane, followed by a 6-h withdrawal period. Similar studies were performed in PND 5 animals with 3 h of ketamine anesthesia. Animals were subsequently perfused and brain tissue processed for analyses. Ketamine (24-h infusion) produced a significant increase in the number of caspase 3-, Fluoro-Jade C- and silver stain-positive cells in the cortex of gestational and PND 5 animals but not in PND 35 animals. Electron microscopy indicated typical nuclear condensation and fragmentation in some neuronal cells, and cell body swelling was observed in others indicating that ketamine-induced neuronal cell death is most likely both apoptotic and necrotic in nature. Ketamine increased N-methyl-D-aspartate (NMDA) receptor NR1 subunit messenger RNA in the frontal cortex where enhanced cell death was apparent. Earlier developmental stages (122 days of gestation and 5 PNDs) appear more sensitive to ketamine-induced neuronal cell death than later in development (35 PNDs). However, a shorter duration of ketamine anesthesia (3 h) did not result in neuronal cell death in the 5-day-old monkey.
JF  - Toxicological sciences : an official journal of the Society of Toxicology
AU  - Slikker, William
AU  - Zou, Xiaoju
AU  - Hotchkiss, Charlotte E
AU  - Divine, Rebecca L
AU  - Sadovova, Natalya
AU  - Twaddle, Nathan C
AU  - Doerge, Daniel R
AU  - Scallet, Andrew C
AU  - Patterson, Tucker A
AU  - Hanig, Joseph P
AU  - Paule, Merle G
AU  - Wang, Cheng
AD  - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079-0502, USA. william.slikker@fda.hhs.gov
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 145
EP  - 158
VL  - 98
IS  - 1
SN  - 1096-6080, 1096-6080
KW  - Anesthetics, Dissociative
KW  - 0
KW  - Excitatory Amino Acid Antagonists
KW  - Fluoresceins
KW  - Organic Chemicals
KW  - RNA, Messenger
KW  - Receptors, N-Methyl-D-Aspartate
KW  - fluoro jade
KW  - Ketamine
KW  - 690G0D6V8H
KW  - Caspase 3
KW  - EC 3.4.22.-
KW  - Index Medicus
KW  - Oximetry
KW  - Animals
KW  - Mass Spectrometry
KW  - Reference Standards
KW  - RNA, Messenger -- genetics
KW  - Autoradiography
KW  - Cell Death -- drug effects
KW  - RNA, Messenger -- biosynthesis
KW  - In Situ Nick-End Labeling
KW  - In Situ Hybridization
KW  - Receptors, N-Methyl-D-Aspartate -- drug effects
KW  - Macaca mulatta
KW  - Microscopy, Electron
KW  - Silver Staining
KW  - Immunohistochemistry
KW  - Caspase 3 -- metabolism
KW  - Ketamine -- pharmacokinetics
KW  - Excitatory Amino Acid Antagonists -- toxicity
KW  - Ketamine -- toxicity
KW  - Neurons -- drug effects
KW  - Anesthetics, Dissociative -- toxicity
KW  - Anesthetics, Dissociative -- pharmacokinetics
KW  - Animals, Newborn -- physiology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-06
N1  - Date created - 2007-06-15
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - A comparison of the pulmonary inflammatory potential of different components of yeast cell wall.
AN  - 70613602; 17558806
AB  - 1-->3-Beta-glucan has been associated with pulmonary inflammation induced by exposure to fungal or yeast cell wall dust. 1-->3-Beta-glucan is the major cell wall component of yeast or fungi. However, the yeast cell wall contains several other components besides 1-->3-beta-glucans, such as mannan and chitin. Few studies evaluated the contribution of these other cell wall components to pulmonary inflammation. The present study compares a crude particulate yeast cell wall preparation (zymosan A) to purified yeast glucan, purified yeast glucan mannan, or purified yeast glucan chitin particles for their potency to induce mouse pulmonary inflammation after in vivo exposure. Mannan is the second most abundant polysaccharide in the yeast cell wall, whereas chitin content is a minor component. The results show that pulmonary injury is mediated by both chitin and 1-->3-beta-glucan and to a lesser degree by mannan. There is also evidence that zymosan is more potent than purified 1-->3-beta-glucan alone. Evidence indicates that 1-->3-beta-glucan is the major inflammatory component in yeast and fungal cell walls.
JF  - Journal of toxicology and environmental health. Part A
AU  - Young, Shih-Houng
AU  - Ostroff, Gary R
AU  - Zeidler-Erdely, Patti C
AU  - Roberts, Jenny R
AU  - Antonini, James M
AU  - Castranova, Vincent
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. sby5@cdc.gov
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 1116
EP  - 1124
VL  - 70
IS  - 13
SN  - 1528-7394, 1528-7394
KW  - beta-Glucans
KW  - 0
KW  - Chitin
KW  - 1398-61-4
KW  - Zymosan
KW  - 9010-72-4
KW  - beta-1,3-glucan
KW  - 9051-97-2
KW  - Index Medicus
KW  - Animals
KW  - Lung -- drug effects
KW  - Cell Wall -- chemistry
KW  - Mice
KW  - Zymosan -- toxicity
KW  - Chitin -- toxicity
KW  - beta-Glucans -- toxicity
KW  - Inflammation -- chemically induced
KW  - Yeasts -- chemistry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-06-20
N1  - Date created - 2007-06-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the third National Health and Nutrition Examination Survey.
AN  - 70603817; 17084837
AB  - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the third National Health and Nutrition Examination Survey. The blood lead levels of the women ranged from 0.7 to 31.1 microg/dl. The estimated geometric mean was 2.2 microg/dl, and the estimated arithmetic mean was 2.8 microg/dl. As the blood lead level increased across women, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of follicle stimulating hormone decreased in pre-menopausal women who were taking birth control pills. The concentration of luteinizing hormone increased as blood lead level increased in post-menopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 1.7 microg/dl for follicle stimulating hormone and 2.8 microg/dl for luteinizing hormone. The increase in follicle stimulating hormone and luteinizing hormone in women with no ovaries indicates that lead may act at a non-ovarian site in the female reproductive system, along with a possible effect on the ovaries.
JF  - Environmental research
AU  - Krieg, Edward F
AD  - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, MS C-22, Cincinnati, OH 45226, USA. erk3@cdc.gov
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 374
EP  - 382
VL  - 104
IS  - 3
SN  - 0013-9351, 0013-9351
KW  - Follicle Stimulating Hormone, Human
KW  - 0
KW  - Lead
KW  - 2P299V784P
KW  - Luteinizing Hormone
KW  - 9002-67-9
KW  - Index Medicus
KW  - United States
KW  - Regression Analysis
KW  - Humans
KW  - Premenopause
KW  - Aged
KW  - Nutrition Surveys
KW  - Multivariate Analysis
KW  - Postmenopause
KW  - Adult
KW  - Surveys and Questionnaires
KW  - Bone Density
KW  - Middle Aged
KW  - Ovariectomy
KW  - Female
KW  - Environmental Monitoring
KW  - Health Surveys
KW  - Luteinizing Hormone -- blood
KW  - Lead -- blood
KW  - Follicle Stimulating Hormone, Human -- blood
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Acute+oral+toxicity+of+colchicine+in+rats%3A+effects+of+gender%2C+vehicle+matrix+and+pre-exposure+to+lipopolysaccharide.&rft.au=Wiesenfeld%2C+Paddy+L%3BGarthoff%2C+Larry+H%3BSobotka%2C+Thomas+J%3BSuagee%2C+Jessica+K%3BBarton%2C+Curtis+N&rft.aulast=Wiesenfeld&rft.aufirst=Paddy&rft.date=2007-09-01&rft.volume=27&rft.issue=5&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-03
N1  - Date created - 2007-06-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain.
AN  - 70569688; 17182183
AB  - Although lumbar radicular pain is the most common chronic neuropathic pain syndrome, there have been few randomized studies of drug treatments. We compared the efficacy of morphine (15-90 mg), nortriptyline (25-100 mg), their combination, and a benztropine "active placebo" (0.25-1 mg) in patients with chronic sciatica. Each period consisted of 5 weeks of dose escalation, 2 weeks of maintenance at the highest tolerated doses, and 2 weeks of dose tapering. The primary outcome was the mean daily leg pain score on a 0-10 scale during the maintenance period. Secondary outcomes included a 6-point ordinal global pain relief scale, the Beck Depression Inventory (BDI), the Oswestry Back Pain Disability Index (ODI) and the SF-36. In the 28 out of 61 patients who completed the study, none of the treatments produced significant reductions in average leg pain or other leg or back pain scores. Pain reduction, relative to placebo treatment was, 14% for nortriptyline (95% CI=[-2%, 30%]), 7% for morphine (95% CI=[-8%, 22%]), and 7% for the combination treatment (95% CI=[-4%, 18%]). Mean doses were: nortriptyline alone, 84+/-24.44 (SD) mg/day; morphine alone, 62+/-29 mg/day; and combination, morphine, 49+/-27 mg/day plus nortriptyline, 55 mg+/-33.18 mg/day. Over half of the study completers reported some adverse effect with morphine, nortriptyline or their combination. Within the limitations of the modest sample size and high dropout rate, these results suggest that nortriptyline, morphine and their combination may have limited effectiveness in the treatment of chronic sciatica.
JF  - Pain
AU  - Khoromi, Suzan
AU  - Cui, Lihong
AU  - Nackers, Lisa
AU  - Max, Mitchell B
AD  - Section on Developmental Genetic Epidemiology, National Institute of Mental Health, Department of Health and Human Services, Bethesda, MD 20892-3720, USA. khoromisu@mail.nih.gov
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 66
EP  - 75
VL  - 130
IS  - 1-2
KW  - Analgesics, Opioid
KW  - 0
KW  - Antidepressive Agents, Tricyclic
KW  - Placebos
KW  - Morphine
KW  - 76I7G6D29C
KW  - Nortriptyline
KW  - BL03SY4LXB
KW  - Index Medicus
KW  - Spinal Nerve Roots
KW  - Humans
KW  - Aged
KW  - Drug Therapy, Combination
KW  - Adult
KW  - Treatment Outcome
KW  - Cross-Over Studies
KW  - Chronic Disease
KW  - Middle Aged
KW  - Female
KW  - Male
KW  - Lumbar Vertebrae
KW  - Antidepressive Agents, Tricyclic -- administration & dosage
KW  - Sciatica -- drug therapy
KW  - Morphine -- adverse effects
KW  - Nortriptyline -- adverse effects
KW  - Antidepressive Agents, Tricyclic -- adverse effects
KW  - Analgesics, Opioid -- adverse effects
KW  - Analgesics, Opioid -- administration & dosage
KW  - Morphine -- administration & dosage
KW  - Nortriptyline -- administration & dosage
KW  - Radiculopathy -- drug therapy
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70569688?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain&rft.atitle=Morphine%2C+nortriptyline+and+their+combination+vs.+placebo+in+patients+with+chronic+lumbar+root+pain.&rft.au=Khoromi%2C+Suzan%3BCui%2C+Lihong%3BNackers%2C+Lisa%3BMax%2C+Mitchell+B&rft.aulast=Khoromi&rft.aufirst=Suzan&rft.date=2007-07-01&rft.volume=130&rft.issue=1-2&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Pain&rft.issn=1872-6623&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-06-27
N1  - Date created - 2007-06-05
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Curr Med Res Opin. 2006 Feb;22(2):375-84 [16466610]
Pain. 2005 Dec 5;118(3):289-305 [16213659]
J Rheumatol. 2000 Mar;27(3):772-8 [10743823]
Spine (Phila Pa 1976). 2000 Dec 15;25(24):3130-9 [11124729]
Spine (Phila Pa 1976). 2001 Mar 1;26(5):E93-E113 [11242399]
Pain. 2001 Nov;94(2):149-58 [11690728]
Anesthesiology. 2002 May;96(5):1053-61 [11981142]
Neurology. 2002 Oct 8;59(7):1015-21 [12370455]
Neurology. 2003 Mar 25;60(6):927-34 [12654955]
N Engl J Med. 2003 Mar 27;348(13):1223-32 [12660386]
Neurology. 2003 Apr 22;60(8):1274-83 [12707429]
Neurology. 2003 Apr 22;60(8):1284-9 [12707430]
Pain. 2003 Sep;105(1-2):71-8 [14499422]
Arch Neurol. 2003 Nov;60(11):1524-34 [14623723]
Am J Med. 2004 Sep 6;117 Suppl 5A:2S-7S [15478846]
Br J Clin Pharmacol. 1979 Jul;8(1):7-20 [552299]
Physiotherapy. 1980 Aug;66(8):271-3 [6450426]
Neurology. 1982 Jun;32(6):671-3 [6283422]
Pain. 1986 Oct;27(1):117-26 [3785962]
J Chronic Dis. 1987;40(3):251-8 [3818881]
Pain. 1988 Apr;33(1):11-23 [2454440]
Neurology. 1988 Sep;38(9):1427-32 [3412591]
Arthritis Rheum. 1990 Feb;33(2):160-72 [2306288]
Clin Pharmacol Ther. 1990 Mar;47(3):305-12 [2178851]
Neurology. 1991 Jul;41(7):1024-8 [1712433]
N Engl J Med. 1992 May 7;326(19):1250-6 [1560801]
Pain. 1993 Nov;55(2):259-66 [8309713]
Lancet. 1996 Jan 20;347(8995):143-7 [8544547]
Lancet. 1997 Mar 15;349(9054):753-8 [9074573]
Neurology. 1998 Jun;50(6):1837-41 [9633737]
Psychosomatics. 1998 May-Jun;39(3):263-72 [9664773]
Pain. 1998 Jun;76(3):287-96 [9718247]
Neurology. 1998 Oct;51(4):1166-71 [9781549]
Pain. 1999 Dec;83(3):389-400 [10568846]
J Pain Symptom Manage. 1998 Oct;16(4):220-9 [9803049]
Neurology. 2004 Dec 14;63(11):2104-10 [15596757]
N Engl J Med. 2005 Mar 31;352(13):1324-34 [15800228]
J Pain. 2005 Apr;6(4):253-60 [15820913]
JAMA. 2005 Jun 22;293(24):3043-52 [15972567]
Expert Rev Neurother. 2005 Nov;5(6):823-30 [16274339]
J Pain. 2005 Dec;6(12):829-36 [16326371]
Anesthesiology. 2006 Jun;104(6):1283-92 [16732101]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - ATSDR evaluation of potential for human exposure to tungsten.
AN  - 70121562; 18386524
AB  - As part of its mandate, the Agency for Toxic Substances and Disease Registry prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation and Liability Act, National Priorities List sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for Tungsten. The primary purpose of this article is to provide interested individuals with environmental information on tungsten that includes production data, environmental fate, potential for human exposure, analytical methods and a listing of regulations and advisories.
JF  - Toxicology and industrial health
AU  - Keith, L Samuel
AU  - Wohlers, David W
AU  - Moffett, Daphne B
AU  - Rosemond, Zemoria A
AU  - Agency for Toxic Substances and Disease Registry
AD  - Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA. skeith@cdc.gov ; Agency for Toxic Substances and Disease Registry
PY  - 2007
SP  - 309
EP  - 345
VL  - 23
IS  - 5-6
SN  - 0748-2337, 0748-2337
KW  - Environmental Pollutants
KW  - 0
KW  - Hazardous Waste
KW  - Tungsten
KW  - V9306CXO6G
KW  - Index Medicus
KW  - United States
KW  - Registries
KW  - Hazardous Waste -- legislation & jurisprudence
KW  - Humans
KW  - United States Dept. of Health and Human Services
KW  - Environmental Pollutants -- analysis
KW  - Environmental Monitoring
KW  - Environmental Exposure
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70121562?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=ATSDR+evaluation+of+potential+for+human+exposure+to+tungsten.&rft.au=Keith%2C+L+Samuel%3BWohlers%2C+David+W%3BMoffett%2C+Daphne+B%3BRosemond%2C+Zemoria+A%3BAgency+for+Toxic+Substances+and+Disease+Registry&rft.aulast=Keith&rft.aufirst=L&rft.date=2007-07-01&rft.volume=23&rft.issue=5-6&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-05-20
N1  - Date created - 2008-04-04
N1  - Date revised - 2017-02-15
N1  - Last updated - 2017-02-15
ER  - 



TY  - JOUR
T1  - Use of multitoxin immunoaffinity columns for determination of aflatoxins and ochratoxin A in ginseng and ginger.
AN  - 68217539; 17760342
AB  - Conditions were optimized for the simultaneous, alkaline, aqueous methanol extraction of aflatoxins (AFL), i.e., B1 (AFB1), B2 (AFB2), G1 (AFG1), and G2 (AFG2), and ochratoxin A (OTA) with subsequent purification, isolation, and determination of the toxins in ginseng and ginger. Powdered roots were extracted with methanol-0.5% NaHCO3 solution (7 + 3). After shaking and centrifugation, the supernatant was diluted with 100 mM phosphate buffer containing 1% Tween 20 and filtered through glass microfiber filter paper. The filtrate was then passed through an immunoaffinity column, and the toxins were eluted with methanol. The AFL were separated and determined by reversed-phase liquid chromatography (RPLC) with fluorescence detection after postcolumn UV photochemical derivatization. OTA was separated and determined by RPLC with fluorescence detection. Recoveries of AFL added at 2-16 ng/g and OTA added at 1-8 ng/g to ginseng were 72-80 and 86-95%, respectively. Recoveries of AFL and OTA added to ginger were similar to those for ginseng. A total of 39 commercially available ginger products from 6 manufacturers were analyzed. Twenty-six samples were found to be contaminated with AFL at 1-31 ng/g and 29 samples, with OTA at 1-10 ng/g. Ten samples contained no AFL or OTA. Ten ginseng finished products were also analyzed; 3 contained AFL at 0.1 ng/g and 4 contained OTA at levels ranging from 0.4 to 1.8 ng/g. LC/tandem mass spectrometry with multiple-reaction monitoring of 3 collisionally induced product ions from the protonated molecular ions of OTA, AFB1, and AFG1 was used to confirm the identities of the toxins in extracts of the finished products.
JF  - Journal of AOAC International
AU  - Trucksess, Mary W
AU  - Weaver, Carol M
AU  - Oles, Carolyn J
AU  - Rump, Lydia V
AU  - White, Kevin D
AU  - Betz, Joseph M
AU  - Rader, Jeanne I
AD  - U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. mary.trucksess@fda.hhs.gov
PY  - 2007
SP  - 1042
EP  - 1049
VL  - 90
IS  - 4
SN  - 1060-3271, 1060-3271
KW  - Aflatoxins
KW  - 0
KW  - Ochratoxins
KW  - Plant Extracts
KW  - Solvents
KW  - ochratoxin A
KW  - 1779SX6LUY
KW  - Index Medicus
KW  - Mass Spectrometry
KW  - Centrifugation
KW  - Chromatography, Liquid -- methods
KW  - Plant Extracts -- metabolism
KW  - Panax -- metabolism
KW  - Spectrophotometry, Ultraviolet -- methods
KW  - Food Contamination
KW  - Plant Roots -- metabolism
KW  - Ochratoxins -- analysis
KW  - Food Analysis -- methods
KW  - Aflatoxins -- analysis
KW  - Ginger -- metabolism
KW  - Immunoassay -- methods
KW  - Chromatography, Ion Exchange -- methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-29
N1  - Date created - 2007-08-31
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The Food and Drug Administration Office of Women's Health: impact of science on regulatory policy.
AN  - 68128542; 17678451
AB  - In 1994, the Food and Drug Administration Office of Women's Health (FDA-OWH) was created to provide leadership and policy direction for the Agency regarding issues of women's health. Within its first year, the FDA-OWH established a science program for women's health research, promoting the development of sound policy and regulation. In a little over a decade, the program has provided approximately 14 million dollars to fund more than 100 women's health research studies covering a broad range of health topics affecting women across their lifespan. Some studies, such as those elucidating drug effects on QT prolongation in women and drug-dietary supplement interaction, have had significant influence on regulatory decisions. Other studies have provided sound scientific data on sex and gender differences supporting FDA guidelines to protect women's health. This paper describes the science program at the FDA-OWH, providing examples of how funded research impacts regulatory policy.
JF  - Journal of women's health (2002)
AU  - Obias-Manno, Dulce
AU  - Scott, Pamela E
AU  - Kaczmarczyk, Joseph
AU  - Miller, Margaret
AU  - Pinnow, Ellen
AU  - Lee-Bishop, Lynda
AU  - Jones-London, Michelle
AU  - Chapman, Kennerly
AU  - Kallgren, Deborah
AU  - Uhl, Kathleen
AD  - Food and Drug Administration, FDA/OC/Office of Women's Health, Rockville, Maryland 20857, USA.
PY  - 2007
SP  - 807
EP  - 817
VL  - 16
IS  - 6
SN  - 1540-9996, 1540-9996
KW  - Index Medicus
KW  - United States
KW  - Policy Making
KW  - Adverse Drug Reaction Reporting Systems -- legislation & jurisprudence
KW  - Humans
KW  - Budgets
KW  - Leadership
KW  - Female
KW  - Women's Health
KW  - Research -- legislation & jurisprudence
KW  - United States Food and Drug Administration -- economics
KW  - Research -- economics
KW  - Health Policy -- legislation & jurisprudence
KW  - United States Food and Drug Administration -- organization & administration
KW  - Health Policy -- trends
KW  - Health Policy -- economics
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-18
N1  - Date created - 2007-08-06
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
J Womens Health (Larchmt). 2007 Jul-Aug;16(6):818-21 [17678452]
N1  - Last updated - 2017-01-18
ER  - 



TY  - BOOK
T1  - Explosion Pressure Design Criteria for New Seals in U.S. Coal Mines
AN  - 58755850; 2007-23621
AB  - Seals are used in underground coal mines throughout the United States to isolate abandoned mining areas from the active workings. Prior to the Sago Mine disaster in 2006, mining regulations required seals to withstand a 140-kPa (20-psig) explosion pressure (30 CFR4 75.335). However, Program Information Bulletin No. P06-16 issued by MSHA on July 19, 2006, requires seals to withstand a 345-kPa (50-psig) explosion pressure. The recently enacted MINER Act requires MSHA to increase this design standard by the end of 2007. This report provides a sound scientific and engineering justification to recommend a three-tiered explosion pressure design criterion for new seals in coal mines in response to the MINER Act. The recommendations contained herein apply to new seal design and construction in U.S. coal mines. Tables, Figures, References.
JF  - United States National Institute for Occupational Safety and Health (NIOSH), July 2007, 84 pp.
AU  - Brune, Jurgen
AU  - Sapko, Michael
AU  - Zipf, Karl
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
EP  - 84p
PB  - United States <span class="hit">National</span> <span class="hit">Institute</span> <span class="hit">for</span> <span class="hit">Occupational</span> <span class="hit">Safety</span> <span class="hit">and</span> <span class="hit">Health</span> (<span class="hit">NIOSH</span>)
KW  - Energy resources and policy - Coal and synthetic gas industry
KW  - Environment and environmental policy - Mining and mineral resources
KW  - Social conditions and policy - Public safety and security
KW  - Mining industry - Accidents - Prevention
KW  - Coal industry - Safety measures
KW  - Explosions
KW  - book
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Brune%2C+Jurgen%3BSapko%2C+Michael%3BZipf%2C+Karl&rft.aulast=Brune&rft.aufirst=Jurgen&rft.date=2007-07-01&rft.volume=&rft.issue=&rft.spage=84p&rft.isbn=&rft.btitle=Explosion+Pressure+Design+Criteria+for+New+Seals+in+U.S.+Coal+Mines&rft.title=Explosion+Pressure+Design+Criteria+for+New+Seals+in+U.S.+Coal+Mines&rft.issn=&rft_id=info:doi/
L2  - http://www.cdc.gov/niosh/mining/pubs/pdfs/2007-144.pdf
LA  - English
DB  - PAIS Index
N1  - Date revised - 2007-12-07
N1  - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - Mental Health Benefits in Employer-sponsored Health Plans, 1997--2003
AN  - 57305639; 200917160
AB  - Data drawn from the Mercer National Survey of Employer-sponsored Health Plans in 1997 and 2003 indicate that a large majority of employers continue to provide some level of coverage for mental health (MH) services in their primary plans. However, a majority of plans continue to impose different benefit limitations for MH than for other medical treatment. Among plans with limitations on MH coverage, there was a sharp increase in the use of limits on inpatient days and outpatient visits between 1997 and 2003. The proportion of employers providing coverage for some MH services decreased; e.g., among small employers, 88% provided coverage for inpatient MH care in 2003, compared with 94% in 1997. These results suggest that parity legislation has had a noticeable but limited effect, but that, at least in the short-term, it is unlikely that universal parity in employer-based plans will be achieved through a legislative strategy. Adapted from the source document.
JF  - The Journal of Behavioral Health Services & Research
AU  - Teich, Judith L
AU  - Buck, Jeffrey A
AD  - Office of Organization and Financing, Center for Mental Health Services, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Room 6-1065, Rockville, MD 20857, USA judith.teich@samhsa.hhs.gov
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 343
EP  - 348
PB  - Lippincott Williams & Wilkins, Philadelphia PA
VL  - 34
IS  - 3
SN  - 1094-3412, 1094-3412
KW  - Coverage
KW  - Mental health services
KW  - Corporate health insurance
KW  - Health insurance
KW  - article
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LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2009-07-06
N1  - Last updated - 2016-09-27
N1  - SubjectsTermNotLitGenreText - Coverage; Health insurance; Corporate health insurance; Mental health services
DO  - http://dx.doi.org/10.1007/s11414-006-9050-2
ER  - 



TY  - JOUR
T1  - A re-examination of distance as a proxy for severity of illness and the implications for differences in utilization by race/ethnicity
AN  - 57137450; 200801484
AB  - The study analyzes the hospitalization patterns of elderly residents to examine whether the relation between distant travel and severity of illness is uniform across racial/ethnic subgroups. A hypothesis is made that severity thresholds could be higher for minorities than whites. Hospital discharge data from the Healthcare Cost and Utilization Project (HCUP-SID) of the Agency for Health Care Research and Quality for New York residents is used, with a link to the Area Resource File and American Hospital Association's survey files. Logistic models compare the association of distant admission with severity corresponding to each local threshold level, race, and type of hospital admission. The study uses four discrete distance thresholds in contrast to recent work. Also, an examination of severity thresholds for distant travel for different types of admission may clarify different sources of disparities in health care utilization. The findings indicate that minorities are likely to have higher severity thresholds than whites in seeking distant hospital care, although these conclusions depend on the type of condition. The study results imply that if costly elective services were regionalized to get the advantages of high volume for both cost and quality of care, some extra effort at outreach may be desirable to reduce disparities in appropriate care. [Copyright 2006 John Wiley and Sons, Ltd.]
JF  - Health Economics
AU  - Basu, Jayasree
AU  - Friedman, Bernard
AD  - Agency for Healthcare Research and Quality, Rockville, USA Jbasu@ahrq.gov
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 687
EP  - 701
PB  - John Wiley, Chichester UK
VL  - 16
IS  - 7
SN  - 1057-9230, 1057-9230
KW  - Travel
KW  - Health costs
KW  - Quality of care
KW  - Health care
KW  - Hospitalization
KW  - Ethnicity
KW  - article
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=A+re-examination+of+distance+as+a+proxy+for+severity+of+illness+and+the+implications+for+differences+in+utilization+by+race%2Fethnicity&rft.au=Basu%2C+Jayasree%3BFriedman%2C+Bernard&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2007-07-01&rft.volume=16&rft.issue=7&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1192
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2008-02-04
N1  - Last updated - 2016-09-27
N1  - CODEN - HEECEZ
N1  - SubjectsTermNotLitGenreText - Hospitalization; Health care; Quality of care; Ethnicity; Health costs; Travel
DO  - http://dx.doi.org/10.1002/hec.1192
ER  - 



TY  - JOUR
T1  - Reservoir simulation-based modeling for characterizing longwall methane emissions and gob gas venthole production
AN  - 50257419; 2007-098286
AB  - Longwall mining alters the fluid-flow-related reservoir properties of the rocks overlying and underlying an extracted panel due to fracturing and relaxation of the strata. These mining-related disturbances create new pressure depletion zones and new flow paths for gas migration and may cause unexpected or uncontrolled migration of gas into the underground workplace. One common technique to control methane emissions in longwall mines is to drill vertical gob gas ventholes into each longwall panel to capture the methane within the overlying fractured strata before it enters the work environment. Thus, it is important to optimize the well parameters, e.g., the borehole diameter, and the length and position of the slotted casing interval relative to the fractured gas-bearing zones. This paper presents the development and results of a comprehensive, "dynamic," three-dimensional reservoir model of a typical multi-panel Pittsburgh coalbed longwall mine. The alteration of permeability fields in and above the panels as a result of the mining-induced disturbances has been estimated from mechanical modeling of the overlying rock mass. Model calibration was performed through history matching the gas production from gob gas ventholes in the study area. Results presented in this paper include a simulation of gas flow patterns from the gas-bearing zones in the overlying strata to the mine environment, as well as the influence of completion practices on optimizing gas production from gob gas ventholes.
JF  - International Journal of Coal Geology
AU  - Karacan, C O
AU  - Esterhuizen, G S
AU  - Schatzel, S J
AU  - Diamond, W P
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 225
EP  - 245
PB  - Elsevier, Amsterdam
VL  - 71
IS  - 2-3
SN  - 0166-5162, 0166-5162
KW  - United States
KW  - mining
KW  - Pittsburgh Coal
KW  - geologic hazards
KW  - underground mining
KW  - Pennsylvanian
KW  - natural gas
KW  - data processing
KW  - petroleum
KW  - rock mechanics
KW  - reservoir rocks
KW  - ventilation
KW  - digital simulation
KW  - numerical models
KW  - Paleozoic
KW  - Carboniferous
KW  - relaxation
KW  - gases
KW  - Allegheny County Pennsylvania
KW  - safety
KW  - longwall mining
KW  - coalbed methane
KW  - Pennsylvania
KW  - Pittsburgh Pennsylvania
KW  - 30:Engineering geology
KW  - 22:Environmental geology
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L2  - http://www.sciencedirect.com/science/journal/01665162
LA  - English
DB  - GeoRef
N1  - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands
N1  - Date revised - 2007-01-01
N1  - Number of references - 33
N1  - Document feature - illus. incl. 4 tables
N1  - Last updated - 2012-06-07
N1  - SubjectsTermNotLitGenreText - Allegheny County Pennsylvania; Carboniferous; coalbed methane; data processing; digital simulation; gases; geologic hazards; longwall mining; mining; natural gas; numerical models; Paleozoic; Pennsylvania; Pennsylvanian; petroleum; Pittsburgh Coal; Pittsburgh Pennsylvania; relaxation; reservoir rocks; rock mechanics; safety; underground mining; United States; ventilation
DO  - http://dx.doi.org/10.1016/j.coal.2006.08.003
ER  - 



TY  - JOUR
T1  - Incorporation of an Internal Ribosome Entry Site-Dependent Mechanism in Arsenic-Induced GADD45 alpha Expression
AN  - 20753839; 7529303
AB  - We have previously shown that trivalent arsenic (arsenite, As super(3+)) is able to induce GADD45 alpha expression in human bronchial epithelial cells through activation of c-Jun NH sub(2)-terminal kinase and nucleolin-dependent mRNA stabilization. In the present report, we show that As super(3+) is capable of inducing translation of the GADD45 alpha protein through a cap-independent, or rather, an internal ribosome entry site (IRES)-dependent mechanism. In growth-arrested cells, As super(3+) elevated the GADD45 alpha protein level in a dose- and time-dependent manner which did not correlate with the GADD45 alpha mRNA expression. Pretreatment of the cells with rapamycin, an inhibitor for the cap-dependent translation machinery through the suppression of mTOR and p70S6 kinase, failed to affect the induction of the GADD45 alpha protein induced by As super(3+). Sequence analysis revealed a potential IRES element in the 5'-untranslated region of the GADD45 alpha mRNA. This IRES element in the 5'-untranslated region of the GADD45 alpha mRNA is functional in mediating As super(3+)-induced translation of the GADD45 alpha protein in a dicistronic reporter gene activity assay. Immunoprecipitation and proteomic studies suggest that As super(3+) impairs the assembly of the cap-dependent initiating complex for general protein translation but increases the association of human elongation factor 2 and human heterogeneous nuclear ribonucleoprotin with this complex. Thus, these results suggest that in growth-arrested cells, As super(3+) is still capable of inducing GADD45 alpha expression through an IRES-dependent translational regulation. [Cancer Res 2007; 67(13):6146-54]
JF  - Cancer Research
AU  - Chang, Qingshan
AU  - Bhatia, Deepak
AU  - Zhang, Yadong
AU  - Meighan, Terry
AU  - Castranova, Vince
AU  - Shi, Xianglin
AU  - Chen, Fei
AD  - The Health Effects Laboratory Division, National Institute for Occupational Safety and Health
Y1  - 2007/07/01/
PY  - 2007
DA  - 2007 Jul 01
SP  - 6146
EP  - 6154
PB  - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/]
VL  - 67
IS  - 13
SN  - 0008-5472, 0008-5472
KW  - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts
KW  - Epithelial cells
KW  - Translation
KW  - Gadd45A protein
KW  - Arsenic
KW  - c-Jun amino-terminal kinase
KW  - Immunoprecipitation
KW  - Arsenite
KW  - Ribosomes
KW  - Cancer
KW  - Gene expression
KW  - Elongation
KW  - Reporter gene
KW  - Ribosomal protein S6 kinase
KW  - Internal ribosome entry site
KW  - proteomics
KW  - 5' Untranslated Regions
KW  - Rapamycin
KW  - X 24360:Metals
KW  - N 14830:RNA
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-08-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Gadd45A protein; Translation; Epithelial cells; Arsenic; c-Jun amino-terminal kinase; Arsenite; Immunoprecipitation; Ribosomes; Cancer; Gene expression; Elongation; Reporter gene; Ribosomal protein S6 kinase; Internal ribosome entry site; proteomics; 5' Untranslated Regions; Rapamycin
ER  - 



TY  - JOUR
T1  - Body Mass and Colorectal Cancer Risk in the NIH-AARP Cohort
AN  - 20729798; 7460162
AB  - In most studies, body mass index (BMI) has been associated with increased risk of colorectal or colon cancer in men, but the relation is weaker and less consistent for women, possibly because of interactions with age or hormone replacement therapy. The authors examined the relation between BMI and colorectal cancer incidence in a large, prospective US cohort of 307,708 men and 209,436 women from the NIH-AARP Diet and Health Study. During follow-up of the cohort from 1995 to 2000, 2,314 cases of colorectal cancer were observed in men and 1,029 in women. BMI was related to increased risk of incident colon cancer, but not rectal cancer, for both men and women. For men, relative risks of colon cancer for a BMI of 18.5-<23, 23-<25, 25-<27.5, 27.5-<30, 30-<32.5, 32.5-<35, 35-<40, and greater than or equal to 40 kg/m super(2) were 1.0 (referent), 1.11, 1.22, 1.44, 1.53, 1.57, 1.71, and 2.39, respectively (95% confidence interval: 1.59, 3.58; p-trend < 0.0005). Corresponding relative risks for women were 1.0, 1.20, 1.29, 1.31, 1.28, 1.13, 1.46, and 1.49 (95% confidence interval: 0.98, 2.25; p-trend = 0.02). BMI was related to colon cancer risk for younger (aged 50-66 years) but not older (aged 67-71 years) women. The association was not modified by hormone replacement therapy in women or physical activity in men or women.
JF  - American Journal of Epidemiology
AU  - Adams, Kenneth F
AU  - Leitzmann, Michael F
AU  - Albanes, Demetrius
AU  - Kipnis, Victor
AU  - Mouw, Traci
AU  - Hollenbeck, Al
AU  - Schatzkin, Arthur
AD  - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD
Y1  - 2007/07/01/
PY  - 2007
DA  - 2007 Jul 01
SP  - 36
EP  - 45
PB  - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 166
IS  - 1
SN  - 0002-9262, 0002-9262
KW  - Risk Abstracts
KW  - Diets
KW  - Age
KW  - colorectal carcinoma
KW  - body mass
KW  - physical activity
KW  - Cancer
KW  - hormone replacement therapy
KW  - R2 23060:Medical and environmental health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729798?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Body+Mass+and+Colorectal+Cancer+Risk+in+the+NIH-AARP+Cohort&rft.au=Adams%2C+Kenneth+F%3BLeitzmann%2C+Michael+F%3BAlbanes%2C+Demetrius%3BKipnis%2C+Victor%3BMouw%2C+Traci%3BHollenbeck%2C+Al%3BSchatzkin%2C+Arthur&rft.aulast=Adams&rft.aufirst=Kenneth&rft.date=2007-07-01&rft.volume=166&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-10-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Diets; Age; body mass; colorectal carcinoma; physical activity; hormone replacement therapy; Cancer
ER  - 



TY  - JOUR
T1  - Regulatory perspectives of Type II prodrug development and time-dependent toxicity management: Nonclinical Pharm/Tox analysis and the role of comparative toxicology
AN  - 20479722; 7499744
AB  - Many therapeutic agents are prepared in prodrug forms, which are classified into Type I, II and subtypes A, B based on their sites of conversion. Recently, an increasing number of INDs have appeared as Type II prodrugs that often contain dual tracks of toxicity profile exploration, one on the prodrug and another on the active drug. A comparative toxicology analysis is introduced here to assist reviewers to evaluate the dual toxicity profiles effectively. The analysis helps determine which toxicity is contributed by the prodrug itself, its intermediates, or the active drug itself. As prodrug INDs, or any other new molecular entity (NME) INDs progress into advanced phases of toxicology development, analysis of time-dependent component of toxicity expression, regarding the emergence of new target organs over time, becomes more significant. A strategy is developed to address Pharm/Tox issues such as what duration is required for a toxicity to emerge at the exposure level achieved or dose studied, how many animals in the group are affected, whether the toxicity is a cross-species phenomenon, and whether it is reversible, etc. In conclusion, dual-track comparative toxicology can be useful in the understanding of Type II prodrug's mechanism of toxicity, and that time-dependent toxicology analysis offers means to detecting new toxicity emergence over time. Both approaches could significantly facilitate secondary and tertiary review processes during IND development of a prodrug or NME.
JF  - Toxicology
AU  - Wu, K M
AU  - Farrelly, J G
AD  - Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States, kueimeng.wu@fda.hhs.gov
Y1  - 2007/07/01/
PY  - 2007
DA  - 2007 Jul 01
SP  - 1
EP  - 6
PB  - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland
VL  - 236
IS  - 1-2
SN  - 0300-483X, 0300-483X
KW  - Toxicology Abstracts
KW  - prodrugs
KW  - Reviews
KW  - Exploration
KW  - Toxicity
KW  - Drugs
KW  - X 24310:Pharmaceuticals
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - prodrugs; Reviews; Exploration; Toxicity; Drugs
DO  - http://dx.doi.org/10.1016/j.tox.2007.04.005
ER  - 



TY  - JOUR
T1  - Successive glycosyltransfer of sialic acid by Escherichia coli K92 polysialyltransferase in elongation of oligosialic acceptors
AN  - 20463923; 9145628
AB  - Escherichia coli K92 produces a capsular polysialic acid with alternating alpha 2,8 alpha 2,9 NeuNAc linkages. This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages by the transfer of NeuNAc from CMP-NeuNAc to the nonreducing end of the growing polymer. We used a fluorescent-based high-performance liquid chromatography assay to characterize the process of chain extension. The PST elongates the acceptor GT3-FCHASE in a biphasic fashion. The initial phase polymers are characterized by accumulation of product containing 1-8 additional sialic acid residues. This phase is followed by a very rapid formation of high-molecular weight (MW) polymer as the accumulated oligosaccharides containing 8-10 sialic acids are consumed. The high-MW polymer contains 90-100 sialic acids and is sensitive to degradation by periodate and K1-5 endoneuraminidase, suggesting that the polymer contains the alternating structure. The polymerization reaction does not appear to be strictly processive, since oligosaccharides of each intermediate size were detected before accumulation of high-molecular weight polymer. Synthesis can be blocked by CMP-9-azido-NeuNAc. These results suggest that the K92 PST forms both alpha 2,8 and alpha 2,9 linkages in a successive and nonprocessive fashion.
JF  - Glycobiology
AU  - Vionnet, Justine
AU  - Vann, Willie F
AD  - Laboratory of Bacterial Polysaccharides , Center for Biologics Evaluation and Research, FDA , Bethesda, MD 20892, wvann@helix.nih.gov
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 735
EP  - 743
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street
VL  - 17
IS  - 7
SN  - 0959-6658, 0959-6658
KW  - Microbiology Abstracts B: Bacteriology
KW  - capsular polysaccharide
KW  - chain extension
KW  - polysialyltransferase
KW  - processivity
KW  - sialic acid
KW  - High-performance liquid chromatography
KW  - Invasiveness
KW  - oligosaccharides
KW  - Polymerization
KW  - Neisseria meningitidis
KW  - Pathogens
KW  - Polysaccharides
KW  - Elongation
KW  - Escherichia coli
KW  - polysialic acid
KW  - Sialic acids
KW  - J 02330:Biochemistry
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-04-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Elongation; Invasiveness; Polymerization; oligosaccharides; polysialyltransferase; Pathogens; polysialic acid; Polysaccharides; Sialic acids; Escherichia coli; Neisseria meningitidis
DO  - http://dx.doi.org/10.1093/glycob/cwm032
ER  - 



TY  - JOUR
T1  - Completeness of Notification of Tuberculosis in the Netherlands: How Reliable Is Record-Linkage and Capture-Recapture Analysis?
AN  - 20462163; 7663136
AB  - The aim of this study was to describe a systematic process of record-linkage, cross-validation, case- ascertainment and capture-recapture analysis to assess the quality of tuberculosis registers and to estimate the completeness of notification of incident tuberculosis cases in The Netherlands in 1998. After record- linkage and cross-validation 1499 tuberculosis patients were identified, of whom 1298 were notified, resulting in an observed under-notification of 13.4%. After adjustment for possible imperfect record-linkage and remaining false-positive hospital cases observed under-notification was 7.3%. Log-linear capture- recapture analysis initially estimated a total number of 2053 (95% CI 1871-2443) tuberculosis cases, resulting in an estimated under-notification of 36.8%. After adjustment for possible imperfect record- linkage and remaining false-positive hospital cases various capture-recapture models estimated under- notification at 13.6%. One of the reasons for the higher than expected estimated under-notification in a country with a well-organized system of tuberculosis control might be that some tuberculosis cases, e.g. extrapulmonary tuberculosis, are managed by clinicians less familiar with notification of infectious diseases. This study demonstrates the possible impact of violation of assumptions underlying capture- recapture analysis, especially the perfect record-linkage, perfect positive predictive value and absent three-way interaction assumptions.
JF  - Epidemiology and Infection
AU  - van hest, NAH
AU  - Smit, F
AU  - Baars, HWM
AU  - de Vries, G
AU  - de Haas, PEW
AU  - Westenend, P J
AU  - Nagelkerke, NJD
AU  - Richardus, J H
AD  - Department of Infectious Disease Control, Rotterdam Public Health Service, Rotterdam, The Netherlands, vanhestr@ggd.rotterdam.nl
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 1021
EP  - 1029
PB  - Cambridge University Press, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org]
VL  - 135
IS  - 6
SN  - 0950-2688, 0950-2688
KW  - Microbiology Abstracts B: Bacteriology
KW  - Infectious diseases
KW  - Mycobacterium
KW  - Tuberculosis
KW  - Hospitals
KW  - Models
KW  - J 02400:Human Diseases
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Completeness+of+Notification+of+Tuberculosis+in+the+Netherlands%3A+How+Reliable+Is+Record-Linkage+and+Capture-Recapture+Analysis%3F&rft.au=van+hest%2C+NAH%3BSmit%2C+F%3BBaars%2C+HWM%3Bde+Vries%2C+G%3Bde+Haas%2C+PEW%3BWestenend%2C+P+J%3BNagelkerke%2C+NJD%3BRichardus%2C+J+H&rft.aulast=van+hest&rft.aufirst=NAH&rft.date=2007-07-01&rft.volume=135&rft.issue=6&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268806007540
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Infectious diseases; Tuberculosis; Models; Hospitals; Mycobacterium
DO  - http://dx.doi.org/10.1017/S0950268806007540
ER  - 



TY  - JOUR
T1  - Characterization of multidrug resistant Salmonella recovered from diseased animals
AN  - 20440225; 7641286
AB  - Three hundred and eighty Salmonella isolates recovered from animal diagnostic samples obtained from four state veterinary diagnostic laboratories (AZ, NC, MO, and TN) between 2002 and 2003 were tested for antimicrobial susceptibilities and further characterized for blaCMY beta-lactamase genes, class 1 integrons and genetic relatedness using PFGE. Forty-seven serovars were identified, the most common being S. Typhimurium (26%), S. Heidelberg (9%), S, Dublin (8%), S. Newport (8%), S. Derby (7%), and S. Choleraesuis (7%). Three hundred and thirteen (82%) isolates were resistant to at least one antimicrobial, and 265 (70%) to three or more antimicrobials. Resistance was most often observed to tetracycline (78%), followed by streptomycin (73%), sulfamethoxazole (68%), and ampicillin (54%), and to a lesser extent chloramphenicol (37%), kanamycin (37%), amoxicillin-clavulanic acid (20%), and ceftiofur (17%). With regards to animal of origin, swine Salmonella isolates displayed the highest rate of resistance, being resistant to at least one antimicrobial (92%), followed by those recovered from turkey (91%), cattle (77%), chicken (68%), and equine (20%). Serovars commonly showing multidrug resistance (MDR) to >=9 antimicrobials were S. Uganda (100%), S. Agona (79%), and S. Newport (62%), compared to S. Heidelberg (11%) and S. Typhimurium (7%). Class-1 integrons were detected in 43% of all isolates, and were found to contain aadA, aadB, dhfr, cmlA and sat1 gene cassettes alone or in various combinations. All ceftiofur resistant isolates (n=66) carried the blaCMY beta-lactamase gene. A total of 230 PFGE patterns were generated among the 380 isolates tested using XbaI, indicating extensive genetic diversity across recovered Salmonella serovars, however, several MDR clones were repeatedly recovered from different diseased animals.
JF  - Veterinary Microbiology
AU  - Zhao, S
AU  - McDermott, P F
AU  - White, D G
AU  - Qaiyumi, S
AU  - Friedman, S L
AU  - Abbott, J W
AU  - Glenn, A
AU  - Ayers, S L
AU  - Post, K W
AU  - Fales, W H
AU  - Wilson, R B
AU  - Reggiardo, C
AU  - Walker, R D
AD  - Office of Research, Center for Veterinary Medicine, U.S. Food & Drug Administration, Laurel, MD 20708, United States, shaohua.zhao@FDA.HHS.GOV
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 122
EP  - 132
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 123
IS  - 1-3
SN  - 0378-1135, 0378-1135
KW  - Microbiology Abstracts B: Bacteriology
KW  - Salmonella
KW  - Antimicrobial resistance
KW  - Diseased animals
KW  - Chloramphenicol
KW  - Sulfamethoxazole
KW  - Genetic diversity
KW  - Ampicillin
KW  - Kanamycin
KW  - Multidrug resistance
KW  - Streptomycin
KW  - Tetracyclines
KW  - J 02410:Animal Diseases
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20440225?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+Microbiology&rft.atitle=Characterization+of+multidrug+resistant+Salmonella+recovered+from+diseased+animals&rft.au=Zhao%2C+S%3BMcDermott%2C+P+F%3BWhite%2C+D+G%3BQaiyumi%2C+S%3BFriedman%2C+S+L%3BAbbott%2C+J+W%3BGlenn%2C+A%3BAyers%2C+S+L%3BPost%2C+K+W%3BFales%2C+W+H%3BWilson%2C+R+B%3BReggiardo%2C+C%3BWalker%2C+R+D&rft.aulast=Zhao&rft.aufirst=S&rft.date=2007-07-01&rft.volume=123&rft.issue=1-3&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Veterinary+Microbiology&rft.issn=03781135&rft_id=info:doi/10.1016%2Fj.vetmic.2007.03.001
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-11-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Chloramphenicol; Sulfamethoxazole; Ampicillin; Genetic diversity; Multidrug resistance; Kanamycin; Streptomycin; Tetracyclines; Salmonella
DO  - http://dx.doi.org/10.1016/j.vetmic.2007.03.001
ER  - 



TY  - JOUR
T1  - Thermally induced filter bias in TEOM mass measurement
AN  - 20397227; 7553320
AB  - Researchers at the National Institute for Occupational Safety and Health (NIOSH) have long used stationary tapered element oscillating microbalances (TEOMs registered ) in laboratory settings. They have served to assess the mass concentration of laboratory-generated particulates in experimental dust chambers and they provide a reference method for comparison with other particulate-measuring instruments. Current NIOSH research is focused on further adapting TEOM technology as a wearable personal dust monitor (PDM) for coal mining occupations. This investigation's goal is to help identify, quantify, and provide means for resolving certain TEOM-related error. The present research investigated bias caused by thermal effects on filter assemblies. New filters used in the PDM for 8 h tests show an average positive bias of 25.5 mu g, while similar tests of equivalent filters used in two 1400A model TEOMs show an average positive bias of 34.3 mu g. The derived bias values allow correction of previously collected biased data. Also, preheating the filters for 24 h at 46 degree C shows significant bias reduction, with PDM pre-heated filters subsequently averaging -3.3 mu g and 1400A TEOM filters averaging 5.9 mu g. On a single-point comparison to gravimetric sampling, a 25.5 mu g bias is only significant at low mass loadings. At 2.5 mg, this bias represents a negligible 1% of the mass measurement. If ordinary linear regression is used, the bias is still insignificant. However, if the more valid weighted linear regression is used, it gives more weight to the smaller dependent variable values, which are more impacted by the bias. Consequently, what is 1% bias on a single high-mass value can translate into a larger bias percentage at high-mass values when performing a weighted regression on data that include a large number of low-mass values.
JF  - Journal of Environmental Monitoring
AU  - Page, S J
AU  - Tuchman, D P
AU  - Vinson, R P
AD  - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 760
EP  - 767
VL  - 9
IS  - 7
SN  - 1464-0325, 1464-0325
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - Filters
KW  - Occupational safety
KW  - Coal
KW  - Particulates
KW  - Mining
KW  - Dust
KW  - Technology
KW  - H 1000:Occupational Safety and Health
KW  - P 6000:TOXICOLOGY AND HEALTH
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Thermally+induced+filter+bias+in+TEOM+mass+measurement&rft.au=Page%2C+S+J%3BTuchman%2C+D+P%3BVinson%2C+R+P&rft.aulast=Page&rft.aufirst=S&rft.date=2007-07-01&rft.volume=9&rft.issue=7&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb704424k
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Filters; Occupational safety; Mining; Particulates; Coal; Dust; Technology
DO  - http://dx.doi.org/10.1039/b704424k
ER  - 



TY  - JOUR
T1  - Citronellal reactions with ozone and OH radical: Rate constants and gas-phase products detected using PFBHA derivatization
AN  - 20358902; 7499358
AB  - The bimolecular rate constants, k sub(O) sub(H) sub(+) sub(c) sub(i) sub(t) sub(r) sub(o) sub(n) sub(e) sub(l) sub(l) sub(a) sub(l), (150+ /-40)x10 super(-) super(1) super(2)cm super(3)molecule super(-) super(1)s super(-) super(1) and, k sub(O) sub(3) sub(+) sub(c) sub(i) sub(t) sub(r) sub(o) sub(n) sub(e) sub(l) sub(l) sub(a) sub(l), (3.5+ /-1.2)x10 super(-) super(1) super(6)cm super(3)molecule super(-) super(1)s super(-) super(1), were measured using the relative rate technique for the reactions of the hydroxyl radical (OH) and ozone (O sub(3)) with 3,7-dimethyl-6-octen-1-al ((R)-(+)-citronellal) at (297+/-3)K and 1atm total pressure. To more clearly define part of citronellal's indoor environment degradation mechanism, the products of the citronellal+OH and citronellal+O sub(3) reactions were also investigated. The positively identified citronellal/OH and citronellal/O sub(3) reaction products were: 3-methylhexanedial HC(?O)CH sub(2)CH sub(2)CH(CH sub(3))CH sub(2)C(?O)H and 2-oxopropanal (methylglyoxal, CH sub(3)C(?O)C(?O)H). The use of derivatizing agent O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) was used to propose 3-methylhexanedial as a major citronellal/OH and citronellal/O sub(3) reaction product. The elucidation of this reaction product was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible citronellal/OH and citronellal/O sub(3) reaction mechanisms based on previously published volatile organic compound/OH and volatile organic compound/O sub(3) gas-phase reaction mechanisms.
JF  - Atmospheric Environment
AU  - Harrison, J C
AU  - Ham, JE
AU  - Wells, J R
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road Morgantown, WV 26505, USA, ozw0@cdc.gov
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 4482
EP  - 4491
PB  - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 41
IS  - 21
SN  - 1352-2310, 1352-2310
KW  - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts
KW  - Ozone measurements
KW  - Mass spectrometry
KW  - Hydroxyl photochemistry
KW  - Indoor environments
KW  - Volatile organic compounds
KW  - Hydroxyl radicals
KW  - Ozone
KW  - M2 551.510.42:Air Pollution (551.510.42)
KW  - P 0000:AIR POLLUTION
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Citronellal+reactions+with+ozone+and+OH+radical%3A+Rate+constants+and+gas-phase+products+detected+using+PFBHA+derivatization&rft.au=Harrison%2C+J+C%3BHam%2C+JE%3BWells%2C+J+R&rft.aulast=Harrison&rft.aufirst=J&rft.date=2007-07-01&rft.volume=41&rft.issue=21&rft.spage=4482&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2007.01.042
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Ozone measurements; Mass spectrometry; Hydroxyl photochemistry; Ozone; Indoor environments; Volatile organic compounds; Hydroxyl radicals
DO  - http://dx.doi.org/10.1016/j.atmosenv.2007.01.042
ER  - 



TY  - JOUR
T1  - Characterization and expansion of baboon CD4 super(+)CD25 super(+) Treg cells for potential use in a non-human primate xenotransplantation model
AN  - 20253217; 8009459
AB  - Abstract: Background: It is well established that CD4 super(+)CD25 super(+) regulatory T (Treg) cells can modulate allogeneic immune responses. Xenotransplantation, proposed as a means to address the critical shortage of human organs, may also benefit from similar approaches to avert rejection. Baboons are a preferred preclinical animal model for xenogeneic organ transplantation experiments, and the characterization of baboon Treg cells will be beneficial to future tolerance studies in this animal model. Methods: We analyzed CD4 super(+)CD25 super(+) T cells from baboon lymph nodes, spleens, and blood by flow cytometry, then purified and expanded porcine antigen-specific baboon CD4 super(+)CD25 super(high) cells in vitro to evaluate their regulatory activity in the baboon anti-pig xenogeneic responses. Results: CD4 super(+)CD25 super(high) T cells were 1.7%, 3.1%, and 1.9% of baboon splenic, lymph node, and blood T cells, respectively. The CD4 super(+)CD25 super(high) T cells expressed the Treg cell-associated transcription factor, FoxP3. Proliferation-suppression assays using irradiated pig peripheral blood mononuclear cells as stimulators showed that Treg cells suppressed the vigorous baboon CD4 super(+)CD25 super(-) T-cell anti-pig proliferation response and cytokine secretion. Expanded baboon Treg cells suppressed baboon anti-pig CD4 super(+)CD25 super(-) T-cell proliferation similar to 4- to 10-fold more than freshly isolated Treg cells. Expanded Treg cells suppressed proliferation to primary cells from the same pig used for expansion more effectively than proliferation to stimulators from a different strain of pig, suggesting a level of antigen specificity. Conclusion: We demonstrate that baboon Treg cells suppress immune responses to xenogeneic stimulation. These studies suggest that adoptive transfer of expanded Treg cells into transplant recipients may provide an approach to prevent cell-mediated rejection of grafts and potentially induce tolerance in the pig to baboon xenotransplantation preclinical model.
JF  - Xenotransplantation
AU  - Porter, Cynthia M
AU  - Horvath-Arcidiacono, Judith A
AU  - Singh, Avneesh K
AU  - Horvath, Keith A
AU  - Bloom, Eda T
AU  - Mohiuddin, Muhammad M
AD  - Division of Cellular and Gene Therapy, CBER, FDA, Bethesda, cynthia.porter@fda.hhs.gov
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 298
EP  - 308
PB  - Blackwell Publishing Ltd., 9600 Garsington Road
VL  - 14
IS  - 4
SN  - 0908-665X, 0908-665X
KW  - Biotechnology and Bioengineering Abstracts; Immunology Abstracts
KW  - baboon
KW  - immune tolerance
KW  - regulatory T cells
KW  - transplantation tolerance
KW  - xenotransplantation
KW  - Papio
KW  - Graft rejection
KW  - Animal models
KW  - Spleen
KW  - CD25 antigen
KW  - Primates
KW  - Immunological tolerance
KW  - Lymph nodes
KW  - Flow cytometry
KW  - CD4 antigen
KW  - Peripheral blood mononuclear cells
KW  - Foxp3 protein
KW  - Transcription factors
KW  - Adoptive transfer
KW  - Lymphocytes T
KW  - Cytokines
KW  - Xenografts
KW  - Immune response
KW  - Cell proliferation
KW  - F 06920:Transplantation
KW  - W 30900:Methods
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenotransplantation&rft.atitle=Characterization+and+expansion+of+baboon+CD4+super%28%2B%29CD25+super%28%2B%29+Treg+cells+for+potential+use+in+a+non-human+primate+xenotransplantation+model&rft.au=Porter%2C+Cynthia+M%3BHorvath-Arcidiacono%2C+Judith+A%3BSingh%2C+Avneesh+K%3BHorvath%2C+Keith+A%3BBloom%2C+Eda+T%3BMohiuddin%2C+Muhammad+M&rft.aulast=Porter&rft.aufirst=Cynthia&rft.date=2007-07-01&rft.volume=14&rft.issue=4&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Xenotransplantation&rft.issn=0908665X&rft_id=info:doi/10.1111%2Fj.1399-3089.2007.00416.x
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Graft rejection; Animal models; Spleen; CD25 antigen; Immunological tolerance; Lymph nodes; Flow cytometry; Peripheral blood mononuclear cells; CD4 antigen; Foxp3 protein; Transcription factors; Lymphocytes T; Adoptive transfer; Cytokines; Immune response; Xenografts; Cell proliferation; Papio; Primates
DO  - http://dx.doi.org/10.1111/j.1399-3089.2007.00416.x
ER  - 



TY  - JOUR
T1  - National policies for xenotransplantation in the USA
AN  - 20253192; 8009443
AB  - Abstract: An overview of xenotransplantation regulatory policies in the USA was presented at the Satellite Symposium, ''Xenotransplantation - Current Standards for Clinical Trials,'' held in conjunction with the World Transplant Congress, Boston, MA, USA 2006. This article summarizes that overview.
JF  - Xenotransplantation
AU  - Bloom, Eda T
AD  - Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA, eda.bloom@fda.hhs.gov
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 345
EP  - 346
PB  - Blackwell Publishing Ltd., 9600 Garsington Road
VL  - 14
IS  - 4
SN  - 0908-665X, 0908-665X
KW  - Biotechnology and Bioengineering Abstracts
KW  - Reviews
KW  - Xenografts
KW  - Clinical trials
KW  - Satellites
KW  - W 30965:Miscellaneous, Reviews
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20253192?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenotransplantation&rft.atitle=National+policies+for+xenotransplantation+in+the+USA&rft.au=Bloom%2C+Eda+T&rft.aulast=Bloom&rft.aufirst=Eda&rft.date=2007-07-01&rft.volume=14&rft.issue=4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Xenotransplantation&rft.issn=0908665X&rft_id=info:doi/10.1111%2Fj.1399-3089.2007.00396.x
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-09-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Reviews; Xenografts; Satellites; Clinical trials
DO  - http://dx.doi.org/10.1111/j.1399-3089.2007.00396.x
ER  - 



TY  - JOUR
T1  - Particle size-dependent radical generation from wildland fire smoke
AN  - 20168149; 7499745
AB  - Firefighting, along with construction, mining and agriculture, ranks among the most dangerous occupations. In addition, the work environment of firefighters is unlike that of any other occupation, not only because of the obvious physical hazards but also due to the respiratory and systemic health hazards of smoke inhalation resulting from combustion. A significant amount of research has been devoted to studying municipal firefighters; however, these studies may not be useful in wildland firefighter exposures, because the two work environments are so different. Not only are wildland firefighters exposed to different combustion products, but their exposure profiles are different. The combustion products wildland firefighters are exposed to can vary greatly in characteristics due to the type and amount of material being burned, soil conditions, temperature and exposure time. Smoke inhalation is one of the greatest concerns for firefighter health and it has been shown that the smoke consists of a large number of particles. These smoke particles contain intermediates of hydrogen, carbon and oxygen free radicals, which may pose a potential health risk. Our investigation looked into the involvement of free radicals in smoke toxicity and the relationship between particle size and radical generation. Samples were collected in discrete aerodynamic particle sizes from a wildfire in Alaska, preserved and then shipped to our laboratory for analysis. Electron spin resonance was used to measure carbon-centered as well as hydroxyl radicals produced by a Fenton-like reaction with wildfire smoke. Further study of reactive oxygen species was conducted using analysis of cellular H sub(2)O sub(2) generation, lipid peroxidation of cellular membranes and DNA damage. Results demonstrate that coarse size-range particles contained more carbon radicals per unit mass than the ultrafine particles; however, the ultrafine particles generated more ?OH radicals in the acellular Fenton-like reaction. The ultrafine particles also caused significant increases in H sub(2)O sub(2) production by monocytes and lipid peroxidation. All particle sizes showed the ability to cause DNA damage. These results indicate that the radical generation and the damage caused by them is not only a function of surface area but is also influenced by changing chemical and other characteristics due to particle size.
JF  - Toxicology
AU  - Leonard, S S
AU  - Castranova, V
AU  - Chen, B T
AU  - Schwegler-Berry, D
AU  - Hoover, M
AU  - Piacitelli, C
AU  - Gaughan, D M
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA, SEL5@cdc.gov
Y1  - 2007/07/01/
PY  - 2007
DA  - 2007 Jul 01
SP  - 103
EP  - 113
PB  - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland
VL  - 236
IS  - 1-2
SN  - 0300-483X, 0300-483X
KW  - Sustainability Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts
KW  - Inhalation
KW  - Agriculture
KW  - wildfire
KW  - firefighter services
KW  - Combustion products
KW  - Lipids
KW  - Soil temperature
KW  - Particulates
KW  - Hydrogen
KW  - Soil
KW  - Carbon
KW  - Reactive oxygen species
KW  - Hydrogen peroxide
KW  - Monocytes
KW  - USA, Alaska
KW  - Particle size
KW  - Fires
KW  - Free radicals
KW  - Surface area
KW  - Temperature
KW  - agriculture
KW  - oxygen free radicals
KW  - Toxicity
KW  - peroxidation
KW  - Lipid peroxidation
KW  - Hydroxyl radicals
KW  - Combustion
KW  - Smoke
KW  - Oxygen
KW  - DNA damage
KW  - Wildfire
KW  - DNA
KW  - Mining
KW  - surface area
KW  - M3 1010:Issues in Sustainable Development
KW  - X 24490:Other
KW  - N 14845:Miscellaneous
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Particle+size-dependent+radical+generation+from+wildland+fire+smoke&rft.au=Leonard%2C+S+S%3BCastranova%2C+V%3BChen%2C+B+T%3BSchwegler-Berry%2C+D%3BHoover%2C+M%3BPiacitelli%2C+C%3BGaughan%2C+D+M&rft.aulast=Leonard&rft.aufirst=S&rft.date=2007-07-01&rft.volume=236&rft.issue=1-2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2007.04.008
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Agriculture; Particle size; Inhalation; Fires; Combustion products; Surface area; Free radicals; Soil temperature; oxygen free radicals; Hydrogen; Toxicity; Lipid peroxidation; Combustion; Soil; Smoke; DNA damage; Wildfire; Carbon; Reactive oxygen species; Hydrogen peroxide; Mining; Monocytes; wildfire; firefighter services; Lipids; agriculture; Temperature; Particulates; peroxidation; Hydroxyl radicals; Oxygen; DNA; surface area; USA, Alaska
DO  - http://dx.doi.org/10.1016/j.tox.2007.04.008
ER  - 



TY  - JOUR
T1  - Antibacterial activities of some mosses including Hylocomium splendens from South Western British Columbia
AN  - 19975896; 7580605
AB  - The antibacterial activity of methanol extracts of ten moss species and fractions prepared from 80% methanol extract of Hylocomium splendens were evaluated by disk diffusion method. Nine moss species showed antibacterial activity against Gram (+) bacteria, in particular H. splendens and its ethyl acetate fractions showed stronger activity. Enhancement of antibacterial activity against Staphylococci by UV-A light irradiation was demonstrated in the extracts of Bartramia pomiformis, Ceratodon purpureus and Neckera douglasii.
JF  - Fitoterapia
AU  - Kang, S J
AU  - Kim, SH
AU  - Liu, P
AU  - Jovel, E
AU  - Towers, GHN
AD  - Korea Food and Drug Administration, Jinheungno, Seoul, 122-704, Republic of Korea, sapium@yahoo.com
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 373
EP  - 376
VL  - 78
IS  - 5
SN  - 0367-326X, 0367-326X
KW  - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - Hylocomium splendens
KW  - U.V. radiation
KW  - Antibacterial activity
KW  - Ceratodon purpureus
KW  - Neckera
KW  - Methanol
KW  - Ethyl acetate
KW  - Bartramia pomiformis
KW  - Diffusion
KW  - Light effects
KW  - A 01340:Antibiotics & Antimicrobials
KW  - J 02340:Antibiotics & Antimicrobials
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19975896?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fitoterapia&rft.atitle=Antibacterial+activities+of+some+mosses+including+Hylocomium+splendens+from+South+Western+British+Columbia&rft.au=Kang%2C+S+J%3BKim%2C+SH%3BLiu%2C+P%3BJovel%2C+E%3BTowers%2C+GHN&rft.aulast=Kang&rft.aufirst=S&rft.date=2007-07-01&rft.volume=78&rft.issue=5&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Fitoterapia&rft.issn=0367326X&rft_id=info:doi/10.1016%2Fj.fitote.2007.03.008
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - U.V. radiation; Antibacterial activity; Ethyl acetate; Methanol; Diffusion; Light effects; Hylocomium splendens; Ceratodon purpureus; Neckera; Bartramia pomiformis
DO  - http://dx.doi.org/10.1016/j.fitote.2007.03.008
ER  - 



TY  - JOUR
T1  - Genome Sequence of a Clinical Isolate of Campylobacter jejuni from Thailand
AN  - 19861413; 7462134
AB  - Campylobacter jejuni CG8486, which belongs to the HS4 complex, was isolated from a patient with inflammatory diarrhea in Thailand. This strain caused a diarrheal disease in ferrets comparable to that caused by C. jejuni strain 81-176, but it was much less invasive for epithelial cells in vitro than 81-176. Complete genome sequencing of CG8486 revealed a 1.65-Mb genome that was very similar to the other two published genomes of clinical isolates of C. jejuni, the genomes of 81-176 and NCTC 11168, with a limited number of CG8486-specific genes mapping outside the hypervariable carbohydrate biosynthesis loci. These data suggest that the genes required for induction of inflammatory diarrhea are among the genes shared by CG8486 and 81-176 but that either major changes in the carbohydrate loci and/or more subtle changes in other genes may modulate virulence.
JF  - Infection and Immunity
AU  - Poly, Frederic
AU  - Read, Timothy
AU  - Tribble, David R
AU  - Baqar, Shahida
AU  - Lorenzo, Maria
AU  - Guerry, Patricia
AD  - Enteric Diseases. Biological Defense Research Directorates, Naval Medical Research Center, Silver Spring, Maryland. Food and Drug Administration, Beltsville, Maryland
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 3425
EP  - 3433
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 75
IS  - 7
SN  - 0019-9567, 0019-9567
KW  - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts
KW  - Genomes
KW  - Clinical isolates
KW  - Epithelial cells
KW  - Diarrhea
KW  - Data processing
KW  - Nucleotide sequence
KW  - Inflammation
KW  - Virulence
KW  - Mustela
KW  - Campylobacter jejuni
KW  - Carbohydrates
KW  - Gene mapping
KW  - N 14845:Miscellaneous
KW  - J 02350:Immunology
KW  - F 06910:Microorganisms & Parasites
KW  - G 07770:Bacteria
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Genome+Sequence+of+a+Clinical+Isolate+of+Campylobacter+jejuni+from+Thailand&rft.au=Poly%2C+Frederic%3BRead%2C+Timothy%3BTribble%2C+David+R%3BBaqar%2C+Shahida%3BLorenzo%2C+Maria%3BGuerry%2C+Patricia&rft.aulast=Poly&rft.aufirst=Frederic&rft.date=2007-07-01&rft.volume=75&rft.issue=7&rft.spage=3425&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Virulence; Clinical isolates; Genomes; Epithelial cells; Data processing; Diarrhea; Nucleotide sequence; Carbohydrates; Gene mapping; Inflammation; Mustela; Campylobacter jejuni
ER  - 



TY  - JOUR
T1  - Characterization of the Zinc-Containing Metalloprotease Encoded by zpx and Development of a Species-Specific Detection Method for Enterobacter sakazakii
AN  - 19861283; 7459696
AB  - Enterobacter sakazakii causes a severe form of neonatal meningitis that occurs as sporadic cases as well as outbreaks. The disease has been epidemiologically associated with consumption of reconstituted, dried infant formulas. Very little information is available regarding pathogenicity of the organism and production of virulence factors. Clinical and environmental strains were screened for production of factors which have activity against Chinese hamster ovary (CHO) cells in tissue culture. Polymyxin B lysate and sonicate preparations but not culture supernatants from the strains caused "rounding" of CHO cells. Subsequent studies showed that the CHO cell-rounding factor is a proteolytic enzyme that has activity against azocasein. The cell-bound protease was isolated by using a combination of polymyxin B lysis, followed by sonication of cells harvested from tryptone broth. The protease was purified to homogeneity by sequential ammonium sulfate precipitation, gel filtration chromatography with Sephadex G-100, hydrophobic interaction chromatography with phenyl-Sepharose CL-4B, and a second gel filtration with Sephadex G-100. In addition to activity against azocasein, the purified protease also exhibits activity against azocoll and insoluble casein but not elastin. The protease has a molecular weight of 38,000 and an isoelectric point of 4.4. It is heat labile and for maximal activity against azocasein has an optimum temperature of 37 degree C and a pH range of 5 to 7. Proteolytic activity is inhibited by ortho-phenanthroline and Zincov but is not affected by phenylmethylsulfonyl fluoride, N-ethylmaleimide, and trypsin inhibitors, which demonstrates that the protease is a zinc-containing metalloprotease. The metalloprotease does not hemagglutinate chicken or sheep erythrocytes. Twenty-three to 27 of the first 42 N-terminal amino acid residues of the metalloprotease are identical to proteases produced by Serratia proteamaculans, Pectobacterium carotovorum, and Anabaena sp. PCR analysis using primers designed from a consensus nucleotide sequence showed that 135 E. sakazakii strains possessed the metalloprotease gene, zpx, and 25 non-E. sakazakii strains did not. The cloned zpx gene of strain 29544 consists of 1,026 nucleotides, and the deduced amino acid sequence of the metalloprotease has 341 amino acid residues, which corresponds to a theoretical protein size of 37,782 with a theoretical pI of 5.23. The sequence possesses three well-characterized zinc-binding and active-site motifs present in other bacterial zinc metalloproteases.
JF  - Applied and Environmental Microbiology
AU  - Kothary, M H
AU  - McCardell, BA
AU  - Frazar, C D
AU  - Deer, D
AU  - Tall, B D
AD  - U.S. Food and Drug Administration, Laurel, Maryland 20708
Y1  - 2007/07/01/
PY  - 2007
DA  - 2007 Jul 01
SP  - 4142
EP  - 4151
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 73
IS  - 13
SN  - 0099-2240, 0099-2240
KW  - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology
KW  - Proteolysis
KW  - Infant formulas
KW  - virulence factors
KW  - Nucleotide sequence
KW  - Erythrocytes
KW  - Anabaena
KW  - Cell culture
KW  - Hydrophobicity
KW  - Serratia proteamaculans
KW  - Azocasein
KW  - Meningitis
KW  - Pectobacterium
KW  - Pathogenicity
KW  - Ammonium sulfate
KW  - Molecular weight
KW  - phenylmethylsulfonyl fluoride
KW  - Polymerase chain reaction
KW  - Elastin
KW  - pH effects
KW  - Proteolytic enzymes
KW  - Temperature effects
KW  - Isoelectric points
KW  - Trypsin
KW  - Chromatography
KW  - Enterobacter sakazakii
KW  - polymyxin B
KW  - Tissue culture
KW  - Precipitation
KW  - Sonication
KW  - Metalloproteinase
KW  - Filtration
KW  - Heat
KW  - Primers
KW  - Amino acid sequence
KW  - N 14810:Methods
KW  - A 01300:Methods
KW  - J 02300:Methods
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Proteolysis; Infant formulas; virulence factors; Nucleotide sequence; Erythrocytes; Hydrophobicity; Cell culture; Azocasein; Meningitis; Ammonium sulfate; Pathogenicity; Molecular weight; Elastin; Polymerase chain reaction; phenylmethylsulfonyl fluoride; pH effects; Proteolytic enzymes; Temperature effects; Isoelectric points; Trypsin; Chromatography; Precipitation; Tissue culture; polymyxin B; Sonication; Metalloproteinase; Filtration; Heat; Primers; Amino acid sequence; Pectobacterium; Enterobacter sakazakii; Anabaena; Serratia proteamaculans
ER  - 



TY  - JOUR
T1  - Extracellular structure of polysialic acid explored by on cell solution NMR
AN  - 19780324; 7533167
AB  - The capsular polysaccharide of the pathogens Neisseria meningitidis serogroup B and of Escherichia coli K1, alpha (2 arrow right 8) polysialic acid (PSA), is unusual, because when injected into adult humans, it generates little or no antibody. In contrast, people infected with these pathogens generate specific serum antibodies. A structural study on cells is used to address this anomaly by characterizing antigen structures in vivo. We introduce on cell multidimensional solution NMR spectroscopy for direct observation of PSA on E. coli bacteria. Using super(13)C, super(15)N-labeled PSA, we applied a combination of heteronuclear NMR methods, such as heteronuclear single quantum coherence, HNCA, and HNCO, in vivo. Analysis reveals that free and cell-bound PSA are structurally similar, indicating that the poor immunogenicity of PSA is not due to major structural differences between cells and purified PSA. The super(13)C linewidths of PSA on cells are 2 to 3 times larger than the corresponding ones in free PSA. The possible implications of the differences between free and on cell PSA are discussed. In addition, we demonstrate the suitability of the method for in vivo kinetic studies.
JF  - Proceedings of the National Academy of Sciences, USA
AU  - Azurmendi, Hugo F
AU  - Vionnet, Justine
AU  - Wrightson, Lauren
AU  - Trinh, Loc B
AU  - Shiloach, Joseph
AU  - Freedberg, Daron I
AD  - Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 11557
EP  - 11561
PB  - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA
VL  - 104
IS  - 28
SN  - 0027-8424, 0027-8424
KW  - Microbiology Abstracts B: Bacteriology
KW  - Antibodies
KW  - Immunogenicity
KW  - Kinetics
KW  - Magnetic resonance spectroscopy
KW  - Escherichia coli
KW  - N.M.R.
KW  - Neisseria meningitidis
KW  - Pathogens
KW  - polysialic acid
KW  - Capsular polysaccharides
KW  - J 02350:Immunology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Extracellular+structure+of+polysialic+acid+explored+by+on+cell+solution+NMR&rft.au=Azurmendi%2C+Hugo+F%3BVionnet%2C+Justine%3BWrightson%2C+Lauren%3BTrinh%2C+Loc+B%3BShiloach%2C+Joseph%3BFreedberg%2C+Daron+I&rft.aulast=Azurmendi&rft.aufirst=Hugo&rft.date=2007-07-01&rft.volume=104&rft.issue=28&rft.spage=11557&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-05-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Antibodies; Immunogenicity; Magnetic resonance spectroscopy; Kinetics; N.M.R.; polysialic acid; Pathogens; Capsular polysaccharides; Escherichia coli; Neisseria meningitidis
ER  - 



TY  - JOUR
T1  - Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling
AN  - 19737198; 7538916
AB  - Consistent with the U.S. Food and Drug Administration (FDA) Critical Path Initiative, predictive toxicology software programs employing quantitative structure-activity relationship (QSAR) models are currently under evaluation for regulatory risk assessment and scientific decision support for highly sensitive endpoints such as carcinogenicity, mutagenicity and reproductive toxicity. At the FDA's Center for Food Safety and Applied Nutrition's Office of Food Additive Safety and the Center for Drug Evaluation and Research's Informatics and Computational Safety Analysis Staff (ICSAS), the use of computational SAR tools for both qualitative and quantitative risk assessment applications are being developed and evaluated. One tool of current interest is MDL-QSAR predictive discriminant analysis modeling of rodent carcinogenicity, which has been previously evaluated for pharmaceutical applications by the FDA ICSAS. The study described in this paper aims to evaluate the utility of this software to estimate the carcinogenic potential of small, organic, naturally occurring chemicals found in the human diet. In addition, a group of 19 known synthetic dietary constituents that were positive in rodent carcinogenicity studies served as a control group. In the test group of naturally occurring chemicals, 101 were found to be suitable for predictive modeling using this software's discriminant analysis modeling approach. Predictions performed on these compounds were compared to published experimental evidence of each compound's carcinogenic potential. Experimental evidence included relevant toxicological studies such as rodent cancer bioassays, rodent anti-carcinogenicity studies, genotoxic studies, and the presence of chemical structural alerts. Statistical indices of predictive performance were calculated to assess the utility of the predictive modeling method. Results revealed good predictive performance using this software's rodent carcinogenicity module of over 1200 chemicals, comprised primarily of pharmaceutical, industrial and some natural products developed under an FDA-MDL cooperative research and development agreement (CRADA). The predictive performance for this group of dietary natural products and the control group was 97% sensitivity and 80% concordance. Specificity was marginal at 53%. This study finds that the in silico QSAR analysis employing this software's rodent carcinogenicity database is capable of identifying the rodent carcinogenic potential of naturally occurring organic molecules found in the human diet with a high degree of sensitivity. It is the first study to demonstrate successful QSAR predictive modeling of naturally occurring carcinogens found in the human diet using an external validation test. Further test validation of this software and expansion of the training data set for dietary chemicals will help to support the future use of such QSAR methods for screening and prioritizing the risk of dietary chemicals when actual animal data are inadequate, equivocal, or absent.
JF  - Toxicology and Applied Pharmacology
AU  - Valerio, L G
AU  - Arvidson, K B
AU  - Chanderbhan, R F
AU  - Contrera, J F
AD  - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-255, 5100 Paint Branch Parkway, College Park, MD 20740, USA, luis.valerio@FDA.HHS.gov
Y1  - 2007/07/01/
PY  - 2007
DA  - 2007 Jul 01
SP  - 1
EP  - 16
PB  - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 222
IS  - 1
SN  - 0041-008X, 0041-008X
KW  - Toxicology Abstracts
KW  - Risk assessment
KW  - Diets
KW  - Mutagenicity
KW  - Genotoxicity
KW  - Animal models
KW  - natural products
KW  - Drug development
KW  - Carcinogens
KW  - Toxicity
KW  - Computer applications
KW  - Nutrition
KW  - Cancer
KW  - Computer programs
KW  - Databases
KW  - Food additives
KW  - software
KW  - Carcinogenicity
KW  - Pharmaceuticals
KW  - Structure-activity relationships
KW  - X 24320:Food Additives & Contaminants
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Diets; Risk assessment; Mutagenicity; Genotoxicity; Animal models; Drug development; natural products; Toxicity; Carcinogens; Computer applications; Nutrition; Cancer; Databases; Computer programs; software; Food additives; Carcinogenicity; Pharmaceuticals; Structure-activity relationships
DO  - http://dx.doi.org/10.1016/j.taap.2007.03.012
ER  - 



TY  - JOUR
T1  - Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine
AN  - 19735891; 7531670
AB  - Flagellin is a key component of the flagella of many pathogens, including Pseudomonas aeruginosa. Flagellin is an attractive vaccine candidate because it is readily produced and manipulated as a recombinant protein and has intrinsic adjuvant activity mediated through TLR5. Although DNA vaccines encoding native Pseudomonas B-type (FliC) or A-type (FlaA) flagellin are strongly immunogenic, the resultant Ab response interferes with the interaction of homologous flagellin with TLR5. This reduces the ability of the host to clear homologous, but not heterologous, flagellin-expressing P. aeruginosa. To circumvent this problem, a DNA vaccine encoding a mutant FliC R90A flagellin was developed. The mutant Ag encoded by this vaccine was highly immunogenic, but its ability to interact with TLR5 was reduced by >100-fold. Vaccination with this flagellin mutant DNA vaccine induced cross-reactive Abs against both FliC and FlaA, but few Abs capable of interfering with TLR5 activation. The flagellin mutant DNA vaccine provided excellent protection against both FliC- and FlaA-expressing P. aeruginosa. These findings suggest that vaccines against flagellated pathogens should avoid inducing Abs against TLR5 and raise the possibility that flagellated bacteria evade host elimination by facilitating the production of Abs that reduce the host's ability to mount an innate immune response.
JF  - Journal of Immunology
AU  - Saha, Sukumar
AU  - Takeshita, Fumihiko
AU  - Matsuda, Tomoko
AU  - Jounai, Nao
AU  - Kobiyama, Kouji
AU  - Matsumoto, Tetsuya
AU  - Sasaki, Shin
AU  - Yoshida, Atsushi
AU  - Xin, Ke-Qin
AU  - Klinman, Dennis M
AU  - Uematsu, Satoshi
AU  - Ishii, Ken J
AU  - Akira, Shizuo
AU  - Okuda, Kenji
AD  - Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. Department of Microbiology, Tokyo Medical University School of Medicine, Tokyo, Japan. Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Department of Host Defense, Research Institute for Microbial Diseases, Osaka, Japan. Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka, Japan
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 1147
EP  - 1154
PB  - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/]
VL  - 179
IS  - 2
SN  - 0022-1767, 0022-1767
KW  - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Immunology Abstracts
KW  - FlaA protein
KW  - Pathogens
KW  - Adjuvants
KW  - Antibody response
KW  - DNA vaccines
KW  - TLR5 protein
KW  - Immunogenicity
KW  - Immune response
KW  - Pseudomonas aeruginosa
KW  - Flagellin
KW  - Toll-like receptors
KW  - Flagella
KW  - F 06905:Vaccines
KW  - N 14845:Miscellaneous
KW  - J 02350:Immunology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - FlaA protein; TLR5 protein; DNA vaccines; Immunogenicity; Antibody response; Immune response; Adjuvants; Pathogens; Flagellin; Toll-like receptors; Flagella; Pseudomonas aeruginosa
ER  - 



TY  - JOUR
T1  - Pro/antioxidant status and AP-1 transcription factor in murine skin following topical exposure to cumene hydroperoxide
AN  - 19734207; 7529437
AB  - Organic peroxides, widely used in the chemical and pharmaceutical industries, can act as skin tumor promoters and cause epidermal hyperplasia. They are also known to trigger free radical generation. The present study evaluated the effect of cumene hydroperoxide (Cum-OOH) on the induction of activator protein-1 (AP-1), which is linked to the expression of genes regulating cell proliferation, growth and transformation. Previously, we reported that topical exposure to Cum-OOH caused formation of free radicals and oxidative stress in the skin of vitamin E-deficient mice. The present study used JB6 P+ mouse epidermal cells and AP-1-luciferase reporter transgenic mice to identify whether exposure to Cum-OOH caused activation of AP-1, oxidative stress, depletion of antioxidants and tumor formation during two-stage carcinogenesis. In vitro studies found that exposure to Cum-OOH reduced the level of glutathione (GSH) in mouse epidermal cells (JB6 P+) and caused the induction of AP-1. Mice primed with dimethyl-benz[a]anthracene (DMBA) were topically exposed to Cum-OOH (82.6 mu mol) or the positive control, 12-O-tetradecanoylphorbol-13-acetate (TPA, 17 nmol), twice weekly for 29 weeks. Activation of AP-1 in skin was detected as early as 2 weeks following Cum-OOH or TPA exposure. No AP-1 expression was found 19 weeks after initiation. Papilloma formation was observed in both the DMBA-TPA- and DMBA-Cum-OOH-exposed animals, whereas skin carcinomas were found only in the DMBA-Cum-OOH-treated mice. A greater accumulation of peroxidative products (thiobarbituric acid-reactive substances), inflammation and decreased levels of GSH and total antioxidant reserves were also observed in the skin of DMBA-Cum-OOH-exposed mice. These results suggest that Cum-OOH-induced carcinogenesis is accompanied by increased AP-1 activation and changes in antioxidant status.
JF  - Carcinogenesis
AU  - Murray, A R
AU  - Kisin, E R
AU  - Kommineni, C
AU  - Vallyathan, V
AU  - Castranova, V
AU  - Shvedova, A A
AD  - Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26505, USA. Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, m/s 2015, 1095 Willowdale Road, Morgantown, WV 26505, USA
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 1582
EP  - 1588
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 28
IS  - 7
SN  - 0143-3334, 0143-3334
KW  - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids
KW  - Transformation
KW  - Antioxidants
KW  - Glutathione
KW  - Free radicals
KW  - Activator protein 1
KW  - Tumors
KW  - Transgenic mice
KW  - cumene hydroperoxide
KW  - TPA
KW  - 12-O-Tetradecanoylphorbol-13-acetate
KW  - skin carcinoma
KW  - Inflammation
KW  - Promoters
KW  - Hyperplasia
KW  - Oxidative stress
KW  - Vitamins
KW  - Transcription factors
KW  - 9,10-Dimethyl-1,2-benzanthracene
KW  - Carcinogenesis
KW  - peroxide
KW  - Pharmaceuticals
KW  - Papilloma
KW  - Cell proliferation
KW  - X 24310:Pharmaceuticals
KW  - N 14835:Protein-Nucleic Acids Association
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-08-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Transformation; Antioxidants; Glutathione; Free radicals; Activator protein 1; Tumors; Transgenic mice; cumene hydroperoxide; 12-O-Tetradecanoylphorbol-13-acetate; TPA; Inflammation; skin carcinoma; Promoters; Hyperplasia; Oxidative stress; 9,10-Dimethyl-1,2-benzanthracene; Transcription factors; Vitamins; Carcinogenesis; Pharmaceuticals; peroxide; Cell proliferation; Papilloma
ER  - 



TY  - JOUR
T1  - Organisms Designated as Nocardia asteroides Drug Pattern Type VI Are Members of the Species Nocardia cyriacigeorgica
AN  - 19728639; 7531482
AB  - Nocardia cyriacigeorgica has recently been described as an "emerging" pathogen. However, DNA-DNA hybridization results confirm that Nocardia asteroides drug pattern type VI, which has long been recognized as a common and significant pathogen in the United States, belongs to the species N. cyriacigeorgica.
JF  - Journal of Clinical Microbiology
AU  - Conville, Patricia S
AU  - Witebsky, Frank G
AD  - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, 10 Center Drive, MSC 1508, Bethesda, Maryland 20892-1508
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 2257
EP  - 2259
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 45
IS  - 7
SN  - 0095-1137, 0095-1137
KW  - Microbiology Abstracts B: Bacteriology
KW  - Pathogens
KW  - Drugs
KW  - Nocardia asteroides
KW  - J 02310:Genetics & Taxonomy
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Pathogens; Drugs; Nocardia asteroides
ER  - 



TY  - JOUR
T1  - Urban Feral Pigeons (Columba livia) as a Source for Air- and Waterborne Contamination with Enterocytozoon bieneusi Spores
AN  - 19714830; 7459724
AB  - This study demonstrated that a person with 30 min of occupational or nonoccupational exposure to urban feral pigeons, such as exposure through the cleaning of surfaces contaminated with pigeon excrement, could inhale approximately 3.5 x 10 super(3) Enterocytozoon bieneusi spores and that 1.3 x 10 super(3) spores could be inhaled by a nearby person.
JF  - Applied and Environmental Microbiology
AU  - Graczyk, Thaddeus K
AU  - Sunderland, Deirdre
AU  - Rule, Ana M
AU  - da Silva, Alexandre J
AU  - Moura, Iaci NS
AU  - Tamang, Leena
AU  - Girouard, Autumn S
AU  - Schwab, Kellogg J
AU  - Breysse, Patrick N
AD  - Division of Environmental Health Engineering, Department of Environmental Health Sciences. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205. Division of Parasitic Diseases, National Center for Zoonotic, Vector-borne, and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Public Services, Atlanta, Georgia 30341. Atlanta Research and Education Foundation and Atlanta VA Medical Center, Decatur, Georgia 30333
Y1  - 2007/07/01/
PY  - 2007
DA  - 2007 Jul 01
SP  - 4357
EP  - 4358
PB  - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/]
VL  - 73
IS  - 13
SN  - 0099-2240, 0099-2240
KW  - Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology
KW  - Contamination
KW  - Enterocytozoon bieneusi
KW  - Spores
KW  - occupational exposure
KW  - Columba livia
KW  - Occupational exposure
KW  - K 03410:Animal Diseases
KW  - H 1000:Occupational Safety and Health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Contamination; Spores; Occupational exposure; occupational exposure; Enterocytozoon bieneusi; Columba livia
ER  - 



TY  - JOUR
T1  - Supplementary breaks and stretching exercises for data entry operators: A follow-up field study
AN  - 19710780; 7512418
AB  - Background This study expanded previous NIOSH-IRS research examining the effects of rest breaks and stretching exercises on symptoms and performance in data-entry workers. Methods All workers spent 4 weeks with conventional breaks (two 15 min breaks per day) and 4 weeks with supplementary breaks (two 15 min breaks plus four 5 min breaks per day). One-half were assigned at random to a group instructed to perform brief stretching exercises during breaks. The remainder comprised the no stretching (control) group. Results 51 workers (stretch group n=21; no stretch group n=30) completed the study symptom questionnaires. Discomfort and eyestrain were significantly lower with supplementary breaks, and supplementary breaks attenuated accumulation of discomfort and eyestrain during work sessions. Data-entry speed was significantly faster with supplementary breaks so that work output was maintained, despite replacing 20 min of work time with break time. In the stretch group, workers reported stretching during only 25% of conventional breaks and 39% of supplementary breaks, and no significant effects of stretching on discomfort or performance were observed. Conclusions These results provide further converging evidence that supplementary breaks reliably minimize discomfort and eyestrain without impairing productivity. Low compliance in performing stretches prevented valid assessment of stretching effects. Further research on stretching exercises and exercise compliance is warranted. Am. J. Ind. Med. 50:519-527, 2007. Published 2007 Wiley-Liss, Inc.
JF  - American Journal of Industrial Medicine
AU  - Galinsky, Traci
AU  - Swanson, Naomi
AU  - Sauter, Steven
AU  - Dunkin, Robin
AU  - Hurrell, Joseph
AU  - Schleifer, Lawrence
AD  - National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, tgalinsky@cdc.gov
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 519
EP  - 527
PB  - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/]
VL  - 50
IS  - 7
SN  - 0271-3586, 0271-3586
KW  - data entry
KW  - Physical Education Index; Health & Safety Science Abstracts
KW  - Work capacity
KW  - Physical activity
KW  - Compliance
KW  - Automation
KW  - Surveys
KW  - Exercise
KW  - Working conditions
KW  - Stretching
KW  - Evaluation
KW  - Speed
KW  - Rest
KW  - Performance
KW  - Ergonomics
KW  - Occupational health
KW  - H 10000:Ergonomics/Human Factors
KW  - PE 030:Exercise, Health & Physical Fitness
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LA  - English
DB  - Physical Education Index; ProQuest Environmental Science Collection
N1  - Date revised - 2007-08-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Evaluation; Speed; Work capacity; Compliance; Rest; Surveys; Performance; Exercise; Stretching; Physical activity; Automation; Working conditions; Ergonomics; Occupational health
DO  - http://dx.doi.org/10.1002/ajim.20472
ER  - 



TY  - JOUR
T1  - Decline in lung function and mortality: implications for medical monitoring
AN  - 19692727; 7464332
AB  - Aim: To investigate the risk of death associated with selected cut-off points for rate of decline of forced expiratory volume in one second (FEV sub(1)). METHODS: Mortality rates of a cohort of 1730 coal miners who had performed two pulmonary function tests 12.8 years apart were followed up for an additional 12 years. Based on previous studies, cut-off points for FEV sub(1) rate of decline (ml/year) were selected as 30, 60 and 90 ml/year. Cox proportional hazard regression was used to estimate multivariate risk ratio of death in each category. RESULTS: The risk ratios (compared to "below 30 ml/year") were 1.39 (95% CI 0.99 to 1.97) in the "60 to less than 90 ml/year" category and 1.90 (95% CI 1.32 to 2.76) in the "90 ml/year and above" category. Rates of decline above 90 ml/year were consistently related to excess mortality. In non-smokers and those with neither restrictive nor obstructive patterns at the first survey, rates of decline above 60 ml/year were significantly associated with increased mortality. CONCLUSIONS: Risk of death increases in individuals with rates of decline above about 60 ml/year and is statistically significant with declines of 90 ml/year or more. These results should be useful to healthcare providers in assessing lung function declines observed in individuals.
JF  - Occupational and Environmental Medicine
AU  - Sircar, Kanta
AU  - Hnizdo, Eva
AU  - Petsonk, Edward
AU  - Attfield, Michael
AD  - National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 461
EP  - 466
PB  - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK
VL  - 64
IS  - 7
SN  - 1351-0711, 1351-0711
KW  - Health & Safety Science Abstracts; Risk Abstracts; Pollution Abstracts
KW  - Mortality
KW  - Occupational safety
KW  - Respiratory function
KW  - Coal
KW  - Mining
KW  - Occupational exposure
KW  - R2 23080:Industrial and labor
KW  - H 1000:Occupational Safety and Health
KW  - P 6000:TOXICOLOGY AND HEALTH
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Mortality; Occupational safety; Mining; Coal; Respiratory function; Occupational exposure
ER  - 



TY  - JOUR
T1  - Prior antibiotics and risk of antibiotic-resistant community-acquired urinary tract infection: a case-control study
AN  - 19688640; 7462238
AB  - BACKGROUND: To assess the effect of previous antibiotic use on the risk of a resistant Escherichia coli urinary tract infection (UTI), we undertook a case-control study with prospective measurement of outcomes in 10 general practices in the UK. METHODS: Urinary samples from all patients with symptoms suggestive of UTIs were sought, and those with a laboratory-proven E. coli infection were interviewed and their medical records examined. Case patients were those with ampicillin- or trimethoprim-resistant infections and control patients had infections that were susceptible to antibiotics, including ampicillin and trimethoprim. RESULTS: Risk of ampicillin-resistant E. coli infection in 903 patients was associated with amoxicillin prescriptions of greater than or equal to 7 days duration in the previous 1 month [odds ratio (OR) = 3.91, 95% CI 1.64-9.34] and previous 2-3 months (2.29, 1.12-4.70) before illness onset. For prescriptions <7 days duration, there was no statistically significant association. Higher doses of amoxicillin were associated with lower risk of ampicillin resistance. For trimethoprim-resistant E. coli infections, the OR was 8.44 (3.12-22.86) for prescriptions of trimethoprim of greater than or equal to 7 days in the previous month and 13.91 (3.32-58.31) for the previous 2-3 months. For trimethoprim prescriptions of <7 days, the OR was 4.03 (1.69-9.59) for the previous month but prescribing in earlier periods was not significantly associated with resistance. CONCLUSIONS: Within the community setting, exposure to antibiotics is a strong risk factor for a resistant E. coli UTI. High-dose, shorter-duration antibiotic regimens may reduce the pressure on the emergence of antibiotic resistance.
JF  - Journal of Antimicrobial Chemotherapy
AU  - Hillier, Sharon
AU  - Roberts, Zoe
AU  - Dunstan, Frank
AU  - Butler, Chris
AU  - Howard, Anthony
AU  - Palmer, Stephen
AD  - Department of Epidemiology, Statistics and Public Health, Centre for Health Sciences Research, Cardiff University, Neuadd Meirionydd, Heath Park, Cardiff CF14 4YS, UK. Department of General Practice, Centre for Health Sciences Research, Cardiff University, Neuadd Meirionydd, Heath Park, Cardiff CF14 4YS, UK. National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, UK
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 92
EP  - 99
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 60
IS  - 1
SN  - 0305-7453, 0305-7453
KW  - Microbiology Abstracts B: Bacteriology
KW  - Trimethoprim
KW  - Amoxicillin
KW  - medical records
KW  - Training
KW  - Statistical analysis
KW  - Ampicillin
KW  - Antibiotics
KW  - Urinary tract
KW  - Infection
KW  - Risk factors
KW  - Escherichia coli
KW  - Pressure
KW  - Antibiotic resistance
KW  - J 02340:Antibiotics & Antimicrobials
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Amoxicillin; Trimethoprim; Training; medical records; Risk factors; Statistical analysis; Ampicillin; Antibiotics; Urinary tract; Pressure; Infection; Antibiotic resistance; Escherichia coli
ER  - 



TY  - JOUR
T1  - Migration of Intradermally Injected Quantum Dots to Sentinel Organs in Mice
AN  - 19687312; 7465391
AB  - Topical exposure to nanoscale materials is likely from a variety of sources including sunscreens and cosmetics. Because the in vivo disposition of nanoscale materials is not well understood, we have evaluated the distribution of quantum dots (QDs) following intradermal injection into female SKH-1 hairless mice as a model system for determining tissue localization following intradermal infiltration. The QD (CdSe core, CdS capped, poly[ethylene glycol] coated, 37 nm diameter, 621 nm fluorescence emission) were injected intradermally (ID) on the right dorsal flank. Within minutes following intradermal injection, the highly UV fluorescent QD could be observed moving from the injection sites apparently through the lymphatic duct system to regional lymph nodes. Residual fluorescent QD remained at the site of injection until necropsy at 24 h. Quantification of cadmium and selenium levels after 0, 4, 8, 12, or 24 h in multiple tissues, using inductively coupled plasma mass spectrometry (ICP-MS), showed a time-dependent loss of cadmium from the injection site, and accumulation in the liver, regional draining lymph nodes, kidney, spleen, and hepatic lymph node. Fluorescence microscopy corroborated the ICP-MS results regarding the tissue distribution of QD. The results indicated that (1) ID injected nanoscale QD remained as a deposit in skin and penetrated the surrounding viable subcutis, (2) QD were distributed to draining lymph nodes through the sc lymphatics and to the liver and other organs, and (3) sentinel organs are effective locations for monitoring transdermal penetration of nanoscale materials into animals.
JF  - Toxicological Sciences
AU  - Gopee, Neera V
AU  - Roberts, Dean W
AU  - Webb, Peggy
AU  - Cozart, Christy R
AU  - Siitonen, Paul H
AU  - Warbritton, Alan R
AU  - Yu, William W
AU  - Colvin, Vicki L
AU  - Walker, Nigel J
AU  - Howard, Paul C
AD  - National Center for Toxicological Research. National Toxicology Program Center for Phototoxicology, U.S. Food and Drug Administration, Jefferson, Arkansas 72079. Toxicology Pathology Associates, Jefferson, Arkansas 72079. Center for Biological and Environmental Nanotechnology and Department of Chemistry, Rice University, Houston, Texas, 77251. National Institute of Environmental Health Sciences, National Institutes of Health, and the National Toxicology Program, Research Triangle Park, North Carolina, 27709
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 249
EP  - 257
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 98
IS  - 1
SN  - 1096-6080, 1096-6080
KW  - Toxicology Abstracts
KW  - Deposits
KW  - Autopsy
KW  - Fluorescence
KW  - Skin
KW  - Spleen
KW  - Cosmetics
KW  - Disposition
KW  - Mass spectroscopy
KW  - Lymph nodes
KW  - Selenium
KW  - Quantum dots
KW  - Kidney
KW  - Liver
KW  - Sunscreens
KW  - Cadmium
KW  - Hairless
KW  - X 24340:Cosmetics, Toiletries & Household Products
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Autopsy; Deposits; Skin; Fluorescence; Spleen; Disposition; Cosmetics; Lymph nodes; Mass spectroscopy; Selenium; Quantum dots; Liver; Kidney; Sunscreens; Hairless; Cadmium
ER  - 



TY  - JOUR
T1  - Lead in pharmaceutical products and dietary supplements
AN  - 19673680; 7435516
AB  - The objective of this study is to determine lead concentrations in a variety of widely used pharmaceutical products, and to assess the risk of lead exposure from using these products. Lead concentrations of 45 products were measured with inductively-coupled plasma mass spectrometry. Six products had lead concentrations greater than 100 parts per billion (ppb), and the highest measured concentration was 500ppb. The average mass of lead delivered to consumers by all products examined in this study when taken as directed was 0.22 micrograms per day, which is expected to increase the blood lead level of an adult by less than 1%. Five products were found to deliver more than 1 mu g of lead per day when used as directed. Current tolerable lead limits in pharmaceutical substances vary widely, and in some cases exceed 10,000ppb. The products examined in this study have lead concentrations far below these levels. However, in light of recent research demonstrating adverse effects in both children and adults from low level lead exposure, current lead limits for pharmaceutical substances are unacceptably high. Uniform lead limits that reflect current manufacturing capabilities are needed to insure the lowest achievable exposure to lead from these products.
JF  - Regulatory Toxicology and Pharmacology
AU  - Kauffman, J F
AU  - Westenberger, B J
AU  - Robertson, J D
AU  - Guthrie, J
AU  - Jacobs, A
AU  - Cummins, S K
AD  - Center for Drug Evaluation and Research, Office of Pharmaceutical Sciences, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, MO 63101, USA, John.Kauffman@fda.hhs.gov
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 128
EP  - 134
PB  - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 48
IS  - 2
SN  - 0273-2300, 0273-2300
KW  - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts
KW  - Consumer products
KW  - dietary supplements
KW  - Heavy metals
KW  - Mass spectrometry
KW  - Children
KW  - Lead
KW  - Mass spectroscopy
KW  - Blood
KW  - Dietary supplements
KW  - Pharmaceuticals
KW  - Consumers
KW  - Side effects
KW  - H 14000:Toxicology
KW  - X 24360:Metals
KW  - R2 23060:Medical and environmental health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-06-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Blood; Dietary supplements; Pharmaceuticals; Consumers; Children; Side effects; Mass spectroscopy; Lead; dietary supplements; Consumer products; Heavy metals; Mass spectrometry
DO  - http://dx.doi.org/10.1016/j.yrtph.2007.03.001
ER  - 



TY  - JOUR
T1  - Dinitrophenol and obesity: An early twentieth-century regulatory dilemma
AN  - 19603084; 7435514
AB  - In the early 1930s, the industrial chemical dinitrophenol found widespread favor as a weight-loss drug, due principally to the work of Maurice Tainter, a clinical pharmacologist from Stanford University. Unfortunately the compound's therapeutic index was razor thin and it was not until thousands of people suffered irreversible harm that mainstream physicians realized that dinitrophenol's risks outweighed its benefits and abandoned its use. Yet, it took passage of the Food, Drug, and Cosmetic Act in 1938 before federal regulators had the ability to stop patent medicine men from selling dinitrophenol to Americans lured by the promise of a drug that would safely melt one's fat away.
JF  - Regulatory Toxicology and Pharmacology
AU  - Colman, E
AD  - Office of Drug Evaluation II, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 22, Room 3360, Silver Spring, MD 20993, USA, eric.colman@fda.hhs.gov
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 115
EP  - 117
PB  - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 48
IS  - 2
SN  - 0273-2300, 0273-2300
KW  - Dinitrophenol
KW  - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts
KW  - Hazards
KW  - Obesity
KW  - Patents
KW  - obesity
KW  - Drugs
KW  - Side effects
KW  - R2 23060:Medical and environmental health
KW  - X 24350:Industrial Chemicals
KW  - H 4000:Food and Drugs
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Dinitrophenol+and+obesity%3A+An+early+twentieth-century+regulatory+dilemma&rft.au=Colman%2C+E&rft.aulast=Colman&rft.aufirst=E&rft.date=2007-07-01&rft.volume=48&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2007.03.006
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-06-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Obesity; Patents; Hazards; obesity; Drugs; Side effects
DO  - http://dx.doi.org/10.1016/j.yrtph.2007.03.006
ER  - 



TY  - JOUR
T1  - Research article: Tuberculosis Control Among People in U.S. Immigration and Customs Enforcement Custody
AN  - 19562314; 8791305
AB  - Abstract not available.
JF  - American Journal of Preventive Medicine
AU  - Schneider, Diana L
AU  - Lobato, Mark N
AD  - Division of Immigration Health Services, U.S. Public Health Service, Washington, DC, Diana.Schneider@dhs.gov
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 9
EP  - 14
PB  - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl]
VL  - 33
IS  - 1
SN  - 0749-3797, 0749-3797
KW  - Microbiology Abstracts B: Bacteriology
KW  - Immigration
KW  - Mycobacterium
KW  - Tuberculosis
KW  - J 02400:Human Diseases
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19562314?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Research+article%3A+Tuberculosis+Control+Among+People+in+U.S.+Immigration+and+Customs+Enforcement+Custody&rft.au=Schneider%2C+Diana+L%3BLobato%2C+Mark+N&rft.aulast=Schneider&rft.aufirst=Diana&rft.date=2007-07-01&rft.volume=33&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2007.02.044
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2009-01-01
N1  - Last updated - 2015-03-30
N1  - SubjectsTermNotLitGenreText - Immigration; Tuberculosis; Mycobacterium
DO  - http://dx.doi.org/10.1016/j.amepre.2007.02.044
ER  - 



TY  - JOUR
T1  - The U.S. Food and Drug Administration's Evidence-Based Review for Qualified Health Claims: Tomatoes, Lycopene, and Cancer
AN  - 19454440; 7531918
AB  - Several studies have reported an inverse association between tomato and/or lycopene intake and the risk of some types of cancer. In 2004, the U.S. Food and Drug Administration (FDA) received two petitions for qualified health claims regarding tomatoes, lycopene, and the risk reduction for some forms of cancer. Health claims that characterize the relationship between a food or food component and a disease or health-related condition require premarket approval by FDA to be included on the labels of conventional foods and dietary supplements. Here we describe FDA's review of the scientific data for tomato and/or lycopene intake with respect to risk reduction for certain forms of cancer. The FDA found no credible evidence to support an association between lycopene intake and a reduced risk of prostate, lung, colorectal, gastric, breast, ovarian, endometrial, or pancreatic cancer. The FDA also found no credible evidence for an assocaition between tomato consumption and a reduced risk of lung, colorectal, breast, cervical, or endometrial cancer. The FDA found very limited evidence to support an association between tomato consumption and reduced risks of prostate, ovarian, gastric, and pancreatic cancers.
JF  - Journal of the National Cancer Institute
AU  - Kavanaugh, Claudine J
AU  - Trumbo, Paula R
AU  - Ellwood, Kathleen C
AD  - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD
Y1  - 2007/07//
PY  - 2007
DA  - Jul 2007
SP  - 1074
EP  - 1085
PB  - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/]
VL  - 99
IS  - 14
SN  - 0027-8874, 0027-8874
KW  - Risk Abstracts
KW  - Lycopersicon esculentum
KW  - risk reduction
KW  - USA
KW  - dietary supplements
KW  - Reviews
KW  - FDA
KW  - Nutrients
KW  - Drugs
KW  - Cancer
KW  - R2 23060:Medical and environmental health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19454440?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=The+U.S.+Food+and+Drug+Administration%27s+Evidence-Based+Review+for+Qualified+Health+Claims%3A+Tomatoes%2C+Lycopene%2C+and+Cancer&rft.au=Kavanaugh%2C+Claudine+J%3BTrumbo%2C+Paula+R%3BEllwood%2C+Kathleen+C&rft.aulast=Kavanaugh&rft.aufirst=Claudine&rft.date=2007-07-01&rft.volume=99&rft.issue=14&rft.spage=1074&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-09-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - risk reduction; dietary supplements; Reviews; FDA; Nutrients; Drugs; Cancer; Lycopersicon esculentum; USA
ER  - 



TY  - JOUR
T1  - Leveraging Philanthropic Investments To Advance Policy Change
AN  - 1504420908; 201401533
AB  - The current Assistant Secretary for Aging, of the U.S. Department of Health and Human Services, describes how the department's Administration on Aging has leveraged the investments of a number of private foundations and entered into a partnership with them to develop, test, and support the initiatives that were eventually included in the Bush administration's Choices for Independence Reauthorization Proposal. An important example of government-foundation partnerships, Choices for Independence was embraced by Congress, and incorporated into the federal Older Americans Act. Adapted from the source document.
JF  - Generations
AU  - Carbonell, Josefina G
AD  - Department of Health and Human Services, Washington, D.C.
Y1  - 2007/07//
PY  - 2007
DA  - July 2007
SP  - 29
EP  - 34
PB  - American Society on Aging, San Francisco CA
VL  - 31
IS  - 2
SN  - 0738-7806, 0738-7806
KW  - Human Services
KW  - Bush Administration
KW  - Aging
KW  - Choices
KW  - Health Behavior
KW  - Legislative Bodies
KW  - article
KW  - 6130: philanthropic/volunteer efforts in social welfare
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504420908?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Generations&rft.atitle=Leveraging+Philanthropic+Investments+To+Advance+Policy+Change&rft.au=Carbonell%2C+Josefina+G&rft.aulast=Carbonell&rft.aufirst=Josefina&rft.date=2007-07-01&rft.volume=31&rft.issue=2&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Generations&rft.issn=07387806&rft_id=info:doi/
LA  - English
DB  - Social Services Abstracts
N1  - Date revised - 2014-03-01
N1  - Last updated - 2016-09-28
N1  - CODEN - GENREC
N1  - SubjectsTermNotLitGenreText - Choices; Aging; Legislative Bodies; Human Services; Health Behavior; Bush Administration
ER  - 



TY  - JOUR
T1  - Petition to request an exemption from 100 percent identity testing of dietary ingredients: Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements. Interim final rule.
AN  - 68123238; 17674485
AB  - The Food and Drug Administration (FDA) is issuing an interim final rule (IFR) that sets forth a procedure for requesting an exemption from the requirement in the final rule "Current Good Manufacturing Practice in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements," published elsewhere in this issue of the Federal Register, that the manufacturer conduct at least one appropriate test or examination to verify the identity of any component that is a dietary ingredient. This IFR allows for submission to, and review by, FDA of an alternative to the required 100 percent identity testing of components that are dietary ingredients, provided certain conditions are met and establishes a requirement for retention of records relating to the FDA's response to an exemption request.
JF  - Federal register
AU  - Food and Drug Administration, HHS
AD  - Food and Drug Administration, HHS
Y1  - 2007/06/25/
PY  - 2007
DA  - 2007 Jun 25
SP  - 34959
EP  - 34969
VL  - 72
IS  - 121
SN  - 0097-6326, 0097-6326
KW  - Health technology assessment
KW  - United States
KW  - Food Contamination -- prevention & control
KW  - Food Handling -- legislation & jurisprudence
KW  - Humans
KW  - Food Packaging -- legislation & jurisprudence
KW  - Food Labeling -- legislation & jurisprudence
KW  - Food Industry -- legislation & jurisprudence
KW  - United States Food and Drug Administration -- legislation & jurisprudence
KW  - Dietary Supplements -- standards
KW  - Quality Control
KW  - Dietary Supplements -- analysis
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68123238?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Petition+to+request+an+exemption+from+100+percent+identity+testing+of+dietary+ingredients%3A+Current+Good+Manufacturing+Practice+in+Manufacturing%2C+Packaging%2C+Labeling%2C+or+Holding+Operations+for+Dietary+Supplements.+Interim+final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2007-06-25&rft.volume=72&rft.issue=121&rft.spage=34959&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-17
N1  - Date created - 2007-08-03
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Current good manufacturing practice in manufacturing, packaging, labeling, or holding operations for dietary supplements. Final rule.
AN  - 68123085; 17674484
AB  - The Food and Drug Administration (FDA) is issuing a final rule regarding current good manufacturing practice (CGMP) for dietary supplements. The final rule establishes the minimum CGMPs necessary for activities related to manufacturing, packaging, labeling, or holding dietary supplements to ensure the quality of the dietary supplement. The final rule is one of many actions related to dietary supplements that we are taking to promote and protect the public health.
JF  - Federal register
AU  - Food and Drug Administration, HHS
AD  - Food and Drug Administration, HHS
Y1  - 2007/06/25/
PY  - 2007
DA  - 2007 Jun 25
SP  - 34751
EP  - 34958
VL  - 72
IS  - 121
SN  - 0097-6326, 0097-6326
KW  - Health technology assessment
KW  - United States
KW  - Food Contamination -- prevention & control
KW  - Public Health
KW  - Sanitation -- legislation & jurisprudence
KW  - Humans
KW  - Food Handling -- legislation & jurisprudence
KW  - Food Industry -- legislation & jurisprudence
KW  - United States Food and Drug Administration -- legislation & jurisprudence
KW  - Food Packaging -- legislation & jurisprudence
KW  - Dietary Supplements -- standards
KW  - Quality Control
KW  - Food Labeling -- legislation & jurisprudence
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Current+good+manufacturing+practice+in+manufacturing%2C+packaging%2C+labeling%2C+or+holding+operations+for+dietary+supplements.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2007-06-25&rft.volume=72&rft.issue=121&rft.spage=34751&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-17
N1  - Date created - 2007-08-03
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice.
AN  - 70605547; 17482224
AB  - Exposure of mice to single-walled carbon nanotubes (SWCNTs) induces an unusually robust pulmonary inflammatory response with an early onset of fibrosis, which is accompanied by oxidative stress and antioxidant depletion. The role of specific components of the antioxidant protective system, specifically vitamin E, the major lipid-soluble antioxidant, in the SWCNT-induced reactions has not been characterized. We used C57BL/6 mice, maintained on vitamin E-sufficient or vitamin E-deficient diets, to explore and compare the pulmonary inflammatory reactions to aspired SWCNTs. The vitamin E-deficient diet caused a 90-fold depletion of alpha-tocopherol in the lung tissue and resulted in a significant decline of other antioxidants (GSH, ascorbate) as well as accumulation of lipid peroxidation products. A greater decrease of pulmonary antioxidants was detected in SWCNT-treated vitamin E-deficient mice as compared to controls. Lowered levels of antioxidants in vitamin E-deficient mice were associated with a higher sensitivity to SWCNT-induced acute inflammation (total number of inflammatory cells, number of polymorphonuclear leukocytes, released LDH, total protein content and levels of pro-inflammatory cytokines, TNF-alpha and IL-6) and enhanced profibrotic responses (elevation of TGF-beta and collagen deposition). Exposure to SWCNTs markedly shifted the ratio of cleaved to full-length extracellular superoxide dismutase (EC-SOD). Given that pulmonary levels of vitamin E can be manipulated through diet, its effects on SWCNT-induced inflammation may be of practical importance in optimizing protective strategies.
JF  - Toxicology and applied pharmacology
AU  - Shvedova, Anna A
AU  - Kisin, Elena R
AU  - Murray, Ashley R
AU  - Gorelik, Olga
AU  - Arepalli, Sivaram
AU  - Castranova, Vincent
AU  - Young, Shih-Hong
AU  - Gao, Fei
AU  - Tyurina, Yulia Y
AU  - Oury, Tim D
AU  - Kagan, Valerian E
AD  - Pathology/Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA. ats1@cdc.gov
Y1  - 2007/06/15/
PY  - 2007
DA  - 2007 Jun 15
SP  - 339
EP  - 348
VL  - 221
IS  - 3
SN  - 0041-008X, 0041-008X
KW  - Antioxidants
KW  - 0
KW  - Cytokines
KW  - Nanotubes, Carbon
KW  - Particulate Matter
KW  - Sod3 protein, mouse
KW  - EC 1.15.1.1
KW  - Superoxide Dismutase
KW  - Glutathione
KW  - GAN16C9B8O
KW  - Ascorbic Acid
KW  - PQ6CK8PD0R
KW  - Index Medicus
KW  - Animals
KW  - Lipid Peroxidation -- immunology
KW  - Glutathione -- metabolism
KW  - Cytokines -- immunology
KW  - Lipid Peroxidation -- drug effects
KW  - Superoxide Dismutase -- metabolism
KW  - Superoxide Dismutase -- drug effects
KW  - Cytokines -- metabolism
KW  - Mice
KW  - Glutathione -- drug effects
KW  - Antioxidants -- metabolism
KW  - Oxidative Stress -- drug effects
KW  - Mice, Inbred C57BL
KW  - Ascorbic Acid -- metabolism
KW  - Oxidative Stress -- immunology
KW  - Female
KW  - Vitamin E Deficiency -- complications
KW  - Particulate Matter -- toxicity
KW  - Vitamin E Deficiency -- immunology
KW  - Lung Diseases -- chemically induced
KW  - Foreign-Body Reaction -- immunology
KW  - Foreign-Body Reaction -- chemically induced
KW  - Foreign-Body Reaction -- metabolism
KW  - Lung Diseases -- metabolism
KW  - Particulate Matter -- immunology
KW  - Lung Diseases -- complications
KW  - Nanotubes, Carbon -- toxicity
KW  - Lung Diseases -- immunology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-07-25
N1  - Date created - 2007-06-08
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Cell shrinkage and monovalent cation fluxes: role in apoptosis.
AN  - 70602753; 17321483
AB  - The loss of cell volume or cell shrinkage has been a morphological hallmark of the programmed cell death process known as apoptosis. This isotonic loss of cell volume has recently been term apoptotic volume decrease or AVD to distinguish it from inherent volume regulatory responses that occurs in cells under anisotonic conditions. Recent studies examining the intracellular signaling pathways that result in this unique cellular characteristic have determined that a fundamental movement of ions, particularly monovalent ions, underlie the AVD process and plays an important role on controlling the cell death process. An efflux of intracellular potassium was shown to be a critical aspect of the AVD process, as preventing this ion loss could protect cells from apoptosis. However, potassium plays a complex role as a loss of intracellular potassium has also been shown to be beneficial to the health of the cell. Additionally, the mechanisms that a cell employs to achieve this loss of intracellular potassium vary depending on the cell type and stimulus used to induce apoptosis, suggesting multiple ways exist to accomplish the same goal of AVD. Additionally, sodium and chloride have been shown to play a vital role during cell death in both the signaling and control of AVD in various apoptotic model systems. This review examines the relationship between this morphological change and intracellular monovalent ions during apoptosis.
JF  - Archives of biochemistry and biophysics
AU  - Bortner, Carl D
AU  - Cidlowski, John A
AD  - The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, NC 27709, USA. bortner@neihs.nih.gov
Y1  - 2007/06/15/
PY  - 2007
DA  - 2007 Jun 15
SP  - 176
EP  - 188
VL  - 462
IS  - 2
SN  - 0003-9861, 0003-9861
KW  - Apoptosis Regulatory Proteins
KW  - 0
KW  - Cations
KW  - Ion Channels
KW  - Chlorine
KW  - 4R7X1O2820
KW  - Sodium
KW  - 9NEZ333N27
KW  - Potassium
KW  - RWP5GA015D
KW  - Index Medicus
KW  - Oxidative Stress -- physiology
KW  - Models, Biological
KW  - Chlorine -- metabolism
KW  - Potassium -- metabolism
KW  - Cytoprotection -- physiology
KW  - Sodium -- metabolism
KW  - Ion Channel Gating -- physiology
KW  - Cell Size
KW  - Apoptosis -- physiology
KW  - Apoptosis Regulatory Proteins -- metabolism
KW  - Ion Channels -- physiology
KW  - Water-Electrolyte Balance -- physiology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70602753?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Cell+shrinkage+and+monovalent+cation+fluxes%3A+role+in+apoptosis.&rft.au=Bortner%2C+Carl+D%3BCidlowski%2C+John+A&rft.aulast=Bortner&rft.aufirst=Carl&rft.date=2007-06-15&rft.volume=462&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-07-31
N1  - Date created - 2007-06-11
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Soluble metals in residual oil fly ash alter innate and adaptive pulmonary immune responses to bacterial infection in rats
AN  - 20607357; 7435552
AB  - The soluble metals of the pollutant, residual oil fly ash (ROFA), have been shown to alter pulmonary bacterial clearance in rats. The goal of this study was to determine the potential effects on both the innate and adaptive lung immune responses after bacterial infection in rats pre-exposed to the soluble metals in ROFA. Sprague-Dawley rats were intratracheally dosed (i.t.) at day 0 with ROFA (R-Total) (1.0 mg/100 g body weight), the soluble fraction of ROFA (R-Soluble), the soluble sample subject to a chelator (R-Chelex), or phosphate-buffered saline (Saline). On day 3, rats were administered an i.t. dose of 5x10 super(4)Listeria monocytogenes. On days 6, 8, and 10, bacterial pulmonary clearance was monitored and bronchoalveolar lavage (BAL) was performed on days 3 (pre-infection), 6, 8, and 10. A concentrated first fraction of lavage fluid was retained for analysis of lactate dehydrogenase and albumin to assess lung injury. BAL cell number, phenotype, and production of reactive oxygen (ROS) and nitrogen species (RNS) were assessed, and a variety of cytokines were measured in the BAL fluid. Rats pre-treated with R-Soluble showed elevated lung injury /cytotoxicity and increased cellular influx into the lungs. R-Soluble-treatment also altered ROS, RNS, and cytokine levels, and caused a degree of macrophage and T cell inhibition. These effects of R-Soluble result in increased pulmonary bacterial burden after infection. The results suggest that soluble metals in ROFA increase lung injury and inflammation, and alter both innate and adaptive pulmonary immune responses.
JF  - Toxicology and Applied Pharmacology
AU  - Roberts, J R
AU  - Young, SH
AU  - Castranova, V
AU  - Antonini, J M
AD  - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA, jur6@cdc.gov
Y1  - 2007/06/15/
PY  - 2007
DA  - 2007 Jun 15
SP  - 306
EP  - 319
PB  - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 221
IS  - 3
SN  - 0041-008X, 0041-008X
KW  - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Immunology Abstracts
KW  - Macrophages
KW  - Bacteria
KW  - Metals
KW  - Injuries
KW  - Cell number
KW  - Fly ash
KW  - Chelating agents
KW  - Infection
KW  - Alveoli
KW  - L-Lactate dehydrogenase
KW  - Inflammation
KW  - Oil
KW  - Oxygen
KW  - Cytotoxicity
KW  - Bronchus
KW  - Pollutants
KW  - Body weight
KW  - Lung
KW  - Albumin
KW  - Lymphocytes T
KW  - Cytokines
KW  - Immune response
KW  - Nitrogen
KW  - F 06955:Immunomodulation & Immunopharmacology
KW  - J 02350:Immunology
KW  - X 24360:Metals
KW  - A 01300:Methods
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20607357?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Soluble+metals+in+residual+oil+fly+ash+alter+innate+and+adaptive+pulmonary+immune+responses+to+bacterial+infection+in+rats&rft.au=Roberts%2C+J+R%3BYoung%2C+SH%3BCastranova%2C+V%3BAntonini%2C+J+M&rft.aulast=Roberts&rft.aufirst=J&rft.date=2007-06-15&rft.volume=221&rft.issue=3&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.03.022
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-06-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Macrophages; Metals; Cell number; Injuries; Fly ash; Infection; Chelating agents; Alveoli; Inflammation; L-Lactate dehydrogenase; Oil; Oxygen; Cytotoxicity; Body weight; Pollutants; Bronchus; Lung; Albumin; Lymphocytes T; Cytokines; Immune response; Nitrogen; Bacteria
DO  - http://dx.doi.org/10.1016/j.taap.2007.03.022
ER  - 



TY  - JOUR
T1  - Backpropagation Artificial Neural Network Classifier to Detect Changes in Heart Sound due to Mitral Valve Regurgitation
AN  - 757014938; 17622023
AB  - The phonocardiograph (PCG) can provide a non-invasive diagnostic ability to the clinicians and technicians to compare the heart acoustic signal obtained from normal and that of pathological heart (cardiac patient). This instrument was connected to the computer through the analog to digital (A/D) converter. The digital data stored for the normal and diseased (mitral valve regurgitation) heart in the computer were decomposed through the Coifman 4th order wavelet kernel. The decomposed phonocardiographic (PCG) data were tested by backpropagation artificial neural network (ANN). The network was containing 64 nodes in the input layer, weighted from the decomposed components of the PCG in the input layer, 16 nodes in the hidden layer and an output node. The ANN was found effective in differentiating the wavelet components of the PCG from mitral valve regurgitation confirmed person (93%) to normal subjects (98%) with an overall performance of 95.5%. This system can also be used to detect the defects in cardiac valves especially, and other several cardiac disorders in general.[PUBLICATION ABSTRACT]
JF  - Journal of Medical Systems
AU  - Sinha, Rakesh Kumar
AU  - Aggarwal, Yogender
AU  - Das, Barda Nand
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 205
EP  - 9
CY  - New York
PB  - Springer Science & Business Media
VL  - 31
IS  - 3
SN  - 0148-5598
KW  - Medical Sciences--Computer Applications
KW  - Neural networks
KW  - Cardiology
KW  - Back propagation
KW  - Humans
KW  - Mitral Valve Insufficiency -- diagnosis
KW  - Neural Networks (Computer)
KW  - Signal Processing, Computer-Assisted -- instrumentation
KW  - Phonocardiography -- methods
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757014938?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomputing&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Systems&rft.atitle=Backpropagation+Artificial+Neural+Network+Classifier+to+Detect+Changes+in+Heart+Sound+due+to+Mitral+Valve+Regurgitation&rft.au=Sinha%2C+Rakesh+Kumar%3BAggarwal%2C+Yogender%3BDas%2C+Barda+Nand&rft.aulast=Sinha&rft.aufirst=Rakesh&rft.date=2007-06-01&rft.volume=31&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Systems&rft.issn=01485598&rft_id=info:doi/10.1007%2Fs10916-007-9056-1
LA  - English
DB  - ProQuest Central
N1  - Copyright - Springer Science+Business Media, LLC 2007
N1  - Last updated - 2014-07-26
DO  - http://dx.doi.org/10.1007/s10916-007-9056-1
ER  - 



TY  - JOUR
T1  - Evaluation of NMR spectral data of urine in conjunction with measured clinical chemistry and histopathology parameters to assess the effects of liver and kidney toxicants
AN  - 745976533; 8638526
AB  - Single low and high doses of several compounds with known renal toxic effects (para-aminophenol, puromycin aminonucleoside, sodium chromate, and hexachlorobutadiene,) or known liver toxic effects (galactosamine, allyl alcohol, and thioacetamide) were administered to male Wistar rats in groups of 4 or 8 for each compound. Predose urine samples (Day 0) and samples from post-dosing (Days 1-4) were collected for each rat and monitored by 1D super(1)H NMR. Principal component analysis (PCA) of the NMR spectra was used to investigate differences between dose levels for each compound individually. The findings from PCA at both dose levels for each compound were examined in the context of the corresponding clinical chemistry and pathology data collected during the study. The PCA clustering of NMR spectra from rats dosed with each individual compound were shown to be associated with the measured levels of creatinine, BUN, AST, ALT and histopathology findings. Finally, scaled-to-maximum, aligned, and reduced trajectories (SMART) analysis was applied to compare the temporal metabolic trajectories obtained for each animal at each dose level of the administered compounds. By day 4, the SMART trajectories for allyl alcohol and hexachlorobutadiene had returned to predose levels indicating a recovery response, however, the high dose SMART trajectories for para-aminophenol, puromycin aminonucleoside, sodium chromate, and galactosamine did not appear to return to predose levels indicating a prolonged toxic effect.
JF  - Metabolomics
AU  - Schnackenberg, Laura K
AU  - Dragan, Yvonne P
AU  - Reily, Michael D
AU  - Robertson, Donald G
AU  - Beger, Richard D
AD  - Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA, richard.beger@fda.hhs.gov
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 87
EP  - 100
PB  - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/]
VL  - 3
IS  - 2
SN  - 1573-3882, 1573-3882
KW  - Toxicology Abstracts
KW  - metabonomics
KW  - metabolic trajectory
KW  - NMR
KW  - renal toxicity
KW  - hepatotoxicity
KW  - sodium chromate
KW  - Data processing
KW  - Toxicants
KW  - Thioacetamide
KW  - Creatinine
KW  - Urine
KW  - Principal components analysis
KW  - allyl alcohol
KW  - Liver
KW  - Kidney
KW  - N.M.R.
KW  - metabolomics
KW  - puromycin
KW  - X 24380:Social Poisons & Drug Abuse
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745976533?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Evaluation+of+NMR+spectral+data+of+urine+in+conjunction+with+measured+clinical+chemistry+and+histopathology+parameters+to+assess+the+effects+of+liver+and+kidney+toxicants&rft.au=Schnackenberg%2C+Laura+K%3BDragan%2C+Yvonne+P%3BReily%2C+Michael+D%3BRobertson%2C+Donald+G%3BBeger%2C+Richard+D&rft.aulast=Schnackenberg&rft.aufirst=Laura&rft.date=2007-06-01&rft.volume=3&rft.issue=2&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-006-0046-y
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2010-05-01
N1  - Last updated - 2015-03-31
N1  - SubjectsTermNotLitGenreText - sodium chromate; Data processing; Toxicants; Thioacetamide; Creatinine; Urine; Principal components analysis; allyl alcohol; Kidney; Liver; N.M.R.; metabolomics; puromycin
DO  - http://dx.doi.org/10.1007/s11306-006-0046-y
ER  - 



TY  - JOUR
T1  - Properties of model-averaged BMDLs: a study of model averaging in dichotomous response risk estimation.
AN  - 70741193; 17640214
AB  - Model averaging (MA) has been proposed as a method of accounting for model uncertainty in benchmark dose (BMD) estimation. The technique has been used to average BMD dose estimates derived from dichotomous dose-response experiments, microbial dose-response experiments, as well as observational epidemiological studies. While MA is a promising tool for the risk assessor, a previous study suggested that the simple strategy of averaging individual models' BMD lower limits did not yield interval estimators that met nominal coverage levels in certain situations, and this performance was very sensitive to the underlying model space chosen. We present a different, more computationally intensive, approach in which the BMD is estimated using the average dose-response model and the corresponding benchmark dose lower bound (BMDL) is computed by bootstrapping. This method is illustrated with TiO(2) dose-response rat lung cancer data, and then systematically studied through an extensive Monte Carlo simulation. The results of this study suggest that the MA-BMD, estimated using this technique, performs better, in terms of bias and coverage, than the previous MA methodology. Further, the MA-BMDL achieves nominal coverage in most cases, and is superior to picking the "best fitting model" when estimating the benchmark dose. Although these results show utility of MA for benchmark dose risk estimation, they continue to highlight the importance of choosing an adequate model space as well as proper model fit diagnostics.
JF  - Risk analysis : an official publication of the Society for Risk Analysis
AU  - Wheeler, Matthew W
AU  - Bailer, A John
AD  - National Institute for Occupational Safety and Health, Risk Evaluation Branch, Cincinnati, OH 45226, USA. MWheeler@cdc.gov
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 659
EP  - 670
VL  - 27
IS  - 3
SN  - 0272-4332, 0272-4332
KW  - titanium dioxide
KW  - 15FIX9V2JP
KW  - Titanium
KW  - D1JT611TNE
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Titanium -- toxicity
KW  - Titanium -- administration & dosage
KW  - Dose-Response Relationship, Drug
KW  - Lung Neoplasms -- chemically induced
KW  - Monte Carlo Method
KW  - Models, Statistical
KW  - Risk Assessment -- statistics & numerical data
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Properties+of+model-averaged+BMDLs%3A+a+study+of+model+averaging+in+dichotomous+response+risk+estimation.&rft.au=Wheeler%2C+Matthew+W%3BBailer%2C+A+John&rft.aulast=Wheeler&rft.aufirst=Matthew&rft.date=2007-06-01&rft.volume=27&rft.issue=3&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=02724332&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-14
N1  - Date created - 2007-07-20
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Antimicrobial susceptibility of Salmonella isolated from various products, from 1999 to 2003.
AN  - 70692693; 17612060
AB  - Foodborne salmonellosis continues to be a major health concern worldwide; thus, detection and tracking of antimicrobial resistance in Salmonella isolates is of interest. The U.S. Food and Drug Administration initiated antimicrobial sensitivity screening of Salmonella isolates from food and related samples in 1999. This paper summarizes the antimicrobial resistance data for Salmonella isolates obtained from 1999 to 2003. A total of 22,231 imported and domestic samples were analyzed for Salmonella, of which 1,319 (5.9%) yielded the pathogen. Since more than one culture was isolated from some samples, the total number of isolates obtained and tested for antimicrobial sensitivity was 1,382. Antimicrobial sensitivity screening was performed with the disc diffusion assay on 11 antimicrobial agents. Of the 1,108 food isolates screened, 42.1% (n = 467) were serotypes Weltevreden, Newport, Lexington, Senftenberg, Typhimurium, Saint Paul, Paratyphi, Enteritidis, Thompson, and Bareilly. A total of 249 (18.0%) isolates from all sources were resistant to two or more antimicrobials. Resistance to sulfisoxazole, streptomycin, and tetracycline was most common, whereas resistance to ciprofloxacin was least common. Weltevreden (n = 148) was the most common serotype isolated from food, but only nine (6.1%) of these isolates were resistant to two or more antimicrobials. In contrast, although Derby was recovered only 19 times, 11 (57.9 %) of these isolates were resistant to two or more antimicrobials. Of the 274 isolates from animal feed, dog treats and environmental swabs, 49.6% (n = 136) belonged to serotypes Infantis, Mbandaka, Anatum, Senftenberg, Typhimurium, Montevideo, Cerro, Enteritidis, and Bredeney, with 76 (27.7%) of these isolates resistant to two or more antimicrobials. Only limited trends in antimicrobial resistance were observed over time, with resistance to sulfisoxazole increasing, resistance to tetracycline decreasing, and resistance to streptomycin fluctuating.
JF  - Journal of food protection
AU  - Kiessling, Connie R
AU  - Jackson, Marc
AU  - Watts, Kathleen A
AU  - Loftis, Mercedes H
AU  - Kiessling, William M
AU  - Buen, Marie B
AU  - Laster, Ebony W
AU  - Sofos, John N
AD  - Denver District Laboratory, U.S. Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, Colorado 80225-0087, USA. connie.kiessling@fda.hhs.gov
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 1334
EP  - 1338
VL  - 70
IS  - 6
SN  - 0362-028X, 0362-028X
KW  - Anti-Bacterial Agents
KW  - 0
KW  - Index Medicus
KW  - Phylogeny
KW  - Animals
KW  - Salmonella Food Poisoning -- prevention & control
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Serotyping
KW  - Colony Count, Microbial
KW  - Drug Resistance, Multiple, Bacterial
KW  - Salmonella -- drug effects
KW  - Food Microbiology
KW  - Drug Resistance, Bacterial
KW  - Food Contamination -- analysis
KW  - Anti-Bacterial Agents -- pharmacology
KW  - Salmonella -- isolation & purification
KW  - Salmonella -- classification
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-14
N1  - Date created - 2007-07-06
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Synthesis and photoirradiation of isomeric ethylchrysenes by UVA light leading to lipid peroxidation.
AN  - 70681366; 17617678
AB  - Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants. We have recently demonstrated that photoirradiation of PAHs leads to cytotoxicity, DNA damage, and induction of lipid peroxidation. In this paper we report the synthesis of all the six isomeric ethylchrysenes and the study of light-induced lipid peroxidation by these ethylchrysenes. 5-Ethylchrysene was synthesized by reaction of 5-keto-5,6,6a,7,8,9,10,10a-octahydrochrysene with CH3CH2MgBr followed by dehydration catalyzed by p-toluenesulfonic acid and dehydrogenation with DDQ in benzene. 1- and 4-Ethylchrysenes were similarly prepared by reaction of 1-keto-1,2,3,4,5,6-hexahydrochrysene and 4-keto-1,2,3,4-tetrahydrochrysenes, respectively with CH3CH2MgBr followed by dehydration and dehydrogenation. Direct acetylation of chrysene followed by Wolff-Kishner or Clemmensen reduction resulted in the formation of 2-, 3-, and 6-ethylchrysenes in 4%, 16%, and 43% yields, respectively. Photoirradiation of these compounds with 7 and 21 J/cm2 UVA light in the presence of methyl linoleate all resulted in lipid peroxidation. For comparison, photoirradiation of 4-methylchrysene and 5-methylchrysene was similarly conducted. For irradiation at a UVA light dose of 21 J/cm2, the level of induced lipid peroxidation is in the order 4-methylchrysene = 5-methylchrysene = 5-ethylchrysene = 4-ethylchrysene = chrysene > 1-ethylchrysene = 2-ethylchrysene > 3-ethylchrysene > 6-ethylchrysene. Compared with chrysene, these results indicate that the ethyl group at C4 or C5 position either slightly enhances or has no effect on the light-induced lipid peroxidation, while at C1-, C2-, C3-, or C6 position reduces light-induced lipid peroxidation.
JF  - International journal of environmental research and public health
AU  - Chen, Hui-Chan
AU  - Xia, Qingsu
AU  - Cherng, Shu-Hui
AU  - Chen, Shoujun
AU  - Lai, Ching-Cheng
AU  - Yu, Hongtao
AU  - Fu, Peter P
AD  - National Center for Toxicological Research, Jefferson, AR 72079, USA.
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 145
EP  - 152
VL  - 4
IS  - 2
SN  - 1661-7827, 1661-7827
KW  - Chrysenes
KW  - 0
KW  - Lipid Peroxides
KW  - Polycyclic Aromatic Hydrocarbons
KW  - Reactive Oxygen Species
KW  - ethylchrysene
KW  - hexahydrochrysene
KW  - octahydrochrysene
KW  - chrysene
KW  - 084HCM49PT
KW  - Index Medicus
KW  - DNA Damage
KW  - Humans
KW  - Phototherapy
KW  - Polycyclic Aromatic Hydrocarbons -- toxicity
KW  - Chrysenes -- toxicity
KW  - Ultraviolet Rays -- adverse effects
KW  - Lipid Peroxidation
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-08
N1  - Date created - 2007-07-09
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
Biosci Biotechnol Biochem. 2000 May;64(5):1044-6 [10879477]
Int J Environ Res Public Health. 2006 Dec;3(4):348-54 [17159277]
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2002 Nov;20(2):149-83 [12515673]
Methods Enzymol. 1984;105:539-50 [6328205]
Anal Biochem. 1987 Jun;163(2):343-9 [3116881]
Chem Res Toxicol. 1992 Mar-Apr;5(2):220-6 [1643251]
Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7491-5 [8052609]
Carcinogenesis. 1995 Aug;16(8):1941-5 [7634425]
Ecotoxicol Environ Saf. 1996 Feb;33(1):1-24 [8744919]
J Mol Med (Berl). 1996 Jun;74(6):297-312 [8862511]
Solid State Nucl Magn Reson. 1998 Oct;12(4):251-6 [9800270]
Chem Res Toxicol. 1999 Jan;12(1):1-18 [9894013]
Chem Res Toxicol. 2005 Feb;18(2):129-38 [15720116]
Toxicol Ind Health. 2006 May;22(4):147-56 [16786836]
Eye (Lond). 2001 Jun;15(Pt 3):371-5 [11450760]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - FDA drug approval summary: bevacizumab (Avastin) plus Carboplatin and Paclitaxel as first-line treatment of advanced/metastatic recurrent nonsquamous non-small cell lung cancer.
AN  - 70663652; 17602060
AB  - On October 11, 2006, the U.S. Food and Drug Administration granted approval for bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA), administered in combination with carboplatin and paclitaxel, for the initial treatment of patients with unresectable, locally advanced, recurrent, or metastatic, nonsquamous, non-small cell lung cancer (NSCLC). Approval is based on a significant improvement in overall survival (OS). A randomized, open label, multicenter clinical trial, conducted by the Eastern Cooperative Oncology Group (ECOG), in chemotherapy-naïve patients with stage IIIB/IV nonsquamous NSCLC, evaluated bevacizumab plus carboplatin and paclitaxel (BV/CP, n = 434) versus carboplatin and paclitaxel alone (CP, n = 444). Exclusion of patients with squamous or predominantly squamous histology was based on life-threatening or fatal hemoptysis occurring in 4 of 13 patients with squamous histology who received a BV/CP regimen in a phase II study. Among the 878 randomized patients, the median age was 63, 46% were female, 76% had stage IV disease, 12% had stage IIIB disease with malignant pleural effusion, 11% had recurrent disease, and 40% had an ECOG performance status score of 0. OS was significantly longer in patients receiving BV/CP than in those receiving CP alone (median OS, 12.3 versus 10.3 months; hazard ratio [HR], 0.80; p = .013, stratified log rank test). Although a consistent effect was observed across most subgroups, in an exploratory analysis, evidence of a survival benefit was not observed in women (HR, 0.99; 95% confidence interval, 0.79-1.25). Severe and life-threatening adverse events occurring more frequently in patients receiving BV/CP were neutropenia (27% versus 17%), fatigue (16% versus 13%), hypertension (8% versus 0.7%), infection without neutropenia (7% versus 3%), thrombosis/embolism (5% versus 3%), pneumonitis or pulmonary infiltrate (5% versus 3%), infection with grade 3 or 4 neutropenia (5% versus 2%), febrile neutropenia (5% versus 2%), hyponatremia (4% versus 1%), proteinuria (3% versus 0), and headache (3% versus 0.5%). Fatal, treatment-related adverse events in patients receiving bevacizumab were pulmonary hemorrhage (2.3% versus 0.5%), gastrointestinal hemorrhage, central nervous system infarction, gastrointestinal perforation, myocardial infarction, and neutropenic sepsis. The most serious, and sometimes fatal, bevacizumab toxicities are gastrointestinal perforation, wound healing complications, hemorrhage, arterial thromboembolic events, hypertensive crisis, nephrotic syndrome, congestive heart failure, and neutropenic sepsis. The most common adverse events in patients receiving bevacizumab are asthenia, pain, abdominal pain, headache, hypertension, diarrhea, nausea, vomiting, anorexia, stomatitis, constipation, upper respiratory infection, epistaxis, dyspnea, exfoliative dermatitis, and proteinuria.
JF  - The oncologist
AU  - Cohen, Martin H
AU  - Gootenberg, Joe
AU  - Keegan, Patricia
AU  - Pazdur, Richard
AD  - Division of Biological Oncology Products, Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. martin.cohen@fda.hhs.gov
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 713
EP  - 718
VL  - 12
IS  - 6
SN  - 1083-7159, 1083-7159
KW  - Antibodies, Monoclonal
KW  - 0
KW  - Antibodies, Monoclonal, Humanized
KW  - Bevacizumab
KW  - 2S9ZZM9Q9V
KW  - Carboplatin
KW  - BG3F62OND5
KW  - Paclitaxel
KW  - P88XT4IS4D
KW  - Index Medicus
KW  - Paclitaxel -- administration & dosage
KW  - United States
KW  - Multicenter Studies as Topic
KW  - Humans
KW  - Vomiting -- chemically induced
KW  - Aged
KW  - Carboplatin -- administration & dosage
KW  - Aged, 80 and over
KW  - Drug Approval
KW  - Adult
KW  - Neoplasm Metastasis
KW  - Treatment Outcome
KW  - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
KW  - Randomized Controlled Trials as Topic
KW  - Neoplasm Staging
KW  - Antineoplastic Combined Chemotherapy Protocols -- adverse effects
KW  - Carboplatin -- adverse effects
KW  - Antibodies, Monoclonal -- administration & dosage
KW  - Headache -- chemically induced
KW  - United States Food and Drug Administration
KW  - Paclitaxel -- adverse effects
KW  - Pain -- chemically induced
KW  - Antibodies, Monoclonal -- adverse effects
KW  - Middle Aged
KW  - Lung Neoplasms -- drug therapy
KW  - Carcinoma, Non-Small-Cell Lung -- drug therapy
KW  - Lung Neoplasms -- pathology
KW  - Carcinoma, Non-Small-Cell Lung -- pathology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-20
N1  - Date created - 2007-07-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Medical fitness evaluation for respirator users: results of a national survey of private sector employers.
AN  - 70610984; 17563613
AB  - To provide information on medical evaluation procedures for respirator use in private sector establishments.
          In 2001, data on respirator use and practices were collected in a survey of private sector establishments. Of establishments where respirators were required, 46% did not evaluate employees' medical fitness. Evaluations for fitness increased with establishment size, ranging from 35% in small establishments (1-10 workers) to 95% in large establishments (>or=1000 workers). Questionnaire with a follow-up examination, as needed, was the most common method of evaluating medical fitness (48%).
          Results suggest that about half of all private sector establishments where respirators are required do not comply with Occupational Safety and Health Administration requirements for medical fitness evaluations. Improved awareness among employers and workers and identification of methods to increase medical evaluation practices, especially among smaller establishments, is needed.
JF  - Journal of occupational and environmental medicine
AU  - Syamlal, Girija
AU  - Doney, Brent
AU  - Bang, Ki Moon
AU  - Greskevitch, Mark
AU  - Groce, Dennis
AU  - Ganocy, Stephen
AU  - Hoffman, William
AD  - National Institute for Occupational Safety and Health (NIOSH), Division of Respiratory Disease Studies, Morgantown, WV 26505, USA. gsyamlal@cdc.gov
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 691
EP  - 699
VL  - 49
IS  - 6
SN  - 1076-2752, 1076-2752
KW  - Index Medicus
KW  - United States
KW  - Humans
KW  - Health Status
KW  - Surveys and Questionnaires
KW  - Equipment Safety -- utilization
KW  - United States Occupational Safety and Health Administration -- standards
KW  - Respiratory Protective Devices -- utilization
KW  - Private Sector
KW  - Occupational Diseases -- prevention & control
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-07-19
N1  - Date created - 2007-06-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Comparison of military and civilian reporting rates for smallpox vaccine adverse events.
AN  - 70598745; 17154344
AB  - US smallpox vaccination (SMA) started most recently in December 2002. Military and civilian personnel report adverse events (AEs) to the Vaccine Adverse Event Reporting System (VAERS), a surveillance system that relies on spontaneous reports. Although reported rates of probable myo/pericarditis after SMA in the literature are similar between military personnel and civilian healthcare workers, some civilian AE reporting rates after SMA appeared higher than those in the military.
          Determine if SMA-associated reporting rates are different in civilians than in the military, considering age, sex, seriousness, and expectedness of the AE, as well as self-reporting. Numerators were SMA reports in VAERS from 12/12/02 to 3/1/04. Limitations of VAERS include underreporting and lack of diagnostic confirmation. Denominators were number of military and civilian vaccinees.
          Reporting rates stratified by age and sex of serious and non-serious AEs were significantly higher in civilian than military personnel ages <55 years (rate ratios 4-27). These rate ratios decreased with increasing age.
          Reporting rates in VAERS differed significantly and substantially in civilians compared to military personnel <55 years of age. Differences in stimulated passive surveillance systems, and AE reporting practices, including the 'threshold' for reporting most likely explain these findings. These results suggest that in the case of smallpox vaccine AEs, there may be systematic differences in reporting completeness between the civilian and military sectors, and that passive surveillance data should be interpreted with caution.
          Copyright (c) 2006 John Wiley & Sons, Ltd.
JF  - Pharmacoepidemiology and drug safety
AU  - McMahon, A W
AU  - Zinderman, C
AU  - Ball, R
AU  - Gupta, G
AU  - Braun, M M
AD  - Office of Biostatistics and Epidemiology, Food and Drug Administration, Rockville, MD, USA. ann.mcmahon@fda.hhs.gov
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 597
EP  - 604
VL  - 16
IS  - 6
SN  - 1053-8569, 1053-8569
KW  - Smallpox Vaccine
KW  - 0
KW  - Index Medicus
KW  - Adverse Drug Reaction Reporting Systems
KW  - Humans
KW  - Adult
KW  - Aged
KW  - Middle Aged
KW  - Vaccination
KW  - Male
KW  - Female
KW  - Military Personnel
KW  - Smallpox Vaccine -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-09
N1  - Date created - 2007-06-11
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - The simultaneous analysis of discrete and continuous outcomes in a dose-response study: using desirability functions.
AN  - 70563668; 17331631
AB  - Multiple types of outcomes are sometimes measured on each animal in toxicology dose-response experiments. The potential false-positive rate from statistical tests on each endpoint may be inflated. We introduce a method of deriving a composite score that combines information from discrete and continuous outcomes through the use of desirability functions. These functions transform observed responses of any type to a 0-to-1 unitless scale. The geometric mean is used to combine the scores and then a statistical model is fit to the dose-response curve of the overall score. The overall desirability score is more sensitive to toxicity evident in only a few endpoints than other composite scores that are based on sums of components. We analyze the overall score using a nonlinear exponential model with a threshold parameter. In this example, the threshold parameter was statistically significant and its estimate was less than the lowest dose. Compared to the vehicle control, the lower overall scores at this dose group were due to lower levels of brain and blood cholinesterase (90% and 82% of control, respectively) whereas other endpoints were not altered, thus demonstrating the sensitivity of the desirability function to detect low levels of toxicity in a small number of outcomes.
JF  - Regulatory toxicology and pharmacology : RTP
AU  - Coffey, Todd
AU  - Gennings, Chris
AU  - Moser, Virginia C
AD  - Department of Biostatistics, Virginia Commonwealth University, PO Box 980032, Richmond, VA 23298, USA. jchen@nctr.fda.gov
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 51
EP  - 58
VL  - 48
IS  - 1
SN  - 0273-2300, 0273-2300
KW  - Cholinesterases
KW  - EC 3.1.1.8
KW  - Index Medicus
KW  - Sensitivity and Specificity
KW  - Rats
KW  - Animals
KW  - Rats, Long-Evans
KW  - Dose-Response Relationship, Drug
KW  - Surveys and Questionnaires
KW  - Male
KW  - Toxicity Tests -- methods
KW  - Models, Statistical
KW  - Toxicity Tests -- standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-09-20
N1  - Date created - 2007-05-28
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Increases in expression of 14-3-3 eta and 14-3-3 zeta transcripts during neuroprotection induced by delta9-tetrahydrocannabinol in AF5 cells.
AN  - 70547093; 17455326
AB  - The molecular mechanisms involved in N-methyl-D-aspartate (NMDA)-induced cell death and Delta9-tetrahydrocannabinol (THC)-induced neuroprotection were investigated in vitro with an AF5 neural progenitor cell line model. By microarray analysis, Ywhah, CK1, Hsp60, Pdcd 4, and Pdcd 7 were identified as being strongly regulated by both NMDA toxicity and THC neuroprotection. The 14-3-3 eta (14-3-3eta; gene symbol Ywhah) and 14-3-3 zeta (14-3-3zeta; gene symbol Ywhaz) transcripts were deceased by NMDA treatment and increased by THC treatment prior to NMDA, as measured by cDNA microarray analysis and quantitative real-time RT-PCR. Other 14-3-3 isoforms were unchanged. Whereas up-regulation of 14-3-3zeta expression was observed 30 min after treatment with THC plus NMDA, down-regulation by NMDA alone was not seen until 16 hr after treatment. By Western blotting, THC increased 14-3-3 protein only in cells that were also treated with NMDA. Overexpression of 14-3-3eta or 14-3-3zeta by transient plasmid transfection increased 14-3-3 protein levels and decreased NMDA-induced cell death. These data suggest that increases in 14-3-3 proteins mediate THC-induced neuroprotection under conditions of NMDA-induced cellular stress.
          Copyright (c) 2007 Wiley-Liss, Inc.
JF  - Journal of neuroscience research
AU  - Chen, Jia
AU  - Lee, Chun-Ting
AU  - Errico, Stacie L
AU  - Becker, Kevin G
AU  - Freed, William J
AD  - Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. jichen@mail.nih.gov
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 1724
EP  - 1733
VL  - 85
IS  - 8
SN  - 0360-4012, 0360-4012
KW  - 14-3-3 Proteins
KW  - 0
KW  - Neuroprotective Agents
KW  - N-Methylaspartate
KW  - 6384-92-5
KW  - Dronabinol
KW  - 7J8897W37S
KW  - Index Medicus
KW  - Rats
KW  - Animals
KW  - Oligonucleotide Array Sequence Analysis
KW  - Transfection
KW  - Plasmids
KW  - Mesencephalon -- cytology
KW  - Cell Line
KW  - N-Methylaspartate -- physiology
KW  - Dronabinol -- pharmacology
KW  - 14-3-3 Proteins -- biosynthesis
KW  - N-Methylaspartate -- toxicity
KW  - N-Methylaspartate -- antagonists & inhibitors
KW  - 14-3-3 Proteins -- genetics
KW  - Neuroprotective Agents -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-11-05
N1  - Date created - 2007-05-24
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Cited By:
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N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Evaluation of the contact and respiratory sensitization potential of volatile organic compounds generated by simulated indoor air chemistry.
AN  - 70519083; 17347135
AB  - Up to 60 million people working indoors experience symptoms such as eye, nose and throat irritation, headache, and fatigue. Investigations into these complaints have ascribed the effects to volatile organic compounds (VOCs) emitted from building materials, cleaning formulations, or other consumer products. New compounds can result when the VOCs react with hydroxyl or nitrate radicals or ozone present in indoor environments. Several oxygenated organic compounds, such as glyoxal, methylglyoxal, glycolaldehyde, and diacetyl, have been identified as possible reaction products of indoor environment chemistry. Although research has previously identified diacetyl and glyoxal as sensitizers, additional experiments were conducted in these studies to further classify their sensitization potential. Sensitization potential of these four compounds was assessed using quantitative structure-activity relationship (QSAR) programs. Derek for Windows and National Institute for Occupational Safety and Health logistic regression predicted all compounds to be sensitizers, while TOPKAT 6.2 predicted all compounds except for methylglyoxal. All compounds were tested in a combined irritancy and local lymph node assay (LLNA). All compounds except for glyoxal were found to be irritants and all tested positive in the LLNA with EC3 values ranging from 0.42 to 1.9%. Methylglyoxal significantly increased both the B220(+) and IgE(+)B220(+) cell populations in the draining lymph nodes and total serum IgE levels. The four compounds generated by indoor air chemistry were predicted by QSAR and animal modeling to be sensitizers, with the potential for methylglyoxal to induce IgE. The identification of these compounds as sensitizers may help to explain some of the health effects associated with indoor air complaints.
JF  - Toxicological sciences : an official journal of the Society of Toxicology
AU  - Anderson, Stacey E
AU  - Wells, J  R
AU  - Fedorowicz, Adam
AU  - Butterworth, Leon F
AU  - Meade, B  J
AU  - Munson, Albert E
AD  - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. sanderson4@cdc.gov
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 355
EP  - 363
VL  - 97
IS  - 2
SN  - 1096-6080, 1096-6080
KW  - Irritants
KW  - 0
KW  - Organic Chemicals
KW  - Immunoglobulin E
KW  - 37341-29-0
KW  - Glyoxal
KW  - 50NP6JJ975
KW  - Pyruvaldehyde
KW  - 722KLD7415
KW  - Acetaldehyde
KW  - GO1N1ZPR3B
KW  - Diacetyl
KW  - K324J5K4HM
KW  - glycolaldehyde
KW  - W0A0XPU08U
KW  - Index Medicus
KW  - Acetaldehyde -- analogs & derivatives
KW  - Animals
KW  - Immunoglobulin E -- blood
KW  - Dose-Response Relationship, Drug
KW  - Diacetyl -- toxicity
KW  - Lymph Nodes -- pathology
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Glyoxal -- toxicity
KW  - Phenotype
KW  - Ear, External -- pathology
KW  - Quantitative Structure-Activity Relationship
KW  - Irritants -- toxicity
KW  - Body Weight -- drug effects
KW  - Acetaldehyde -- toxicity
KW  - Pyruvaldehyde -- toxicity
KW  - Lymph Nodes -- drug effects
KW  - Female
KW  - Organ Size -- drug effects
KW  - Dermatitis, Contact -- pathology
KW  - Air Pollution, Indoor -- adverse effects
KW  - Organic Chemicals -- toxicity
KW  - Organic Chemicals -- administration & dosage
KW  - Respiratory Tract Diseases -- chemically induced
KW  - Respiratory Tract Diseases -- pathology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-06
N1  - Date created - 2007-05-22
N1  - Date revised - 2017-01-13
N1  - SuppNotes - Comment In:
Food Chem Toxicol. 2014 Aug;70:260-1 [24857818]
Food Chem Toxicol. 2014 Aug;70:262-3 [24857816]
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Exposure to the immunosuppressant, perfluorooctanoic acid, enhances the murine IgE and airway hyperreactivity response to ovalbumin.
AN  - 70516933; 17369199
AB  - These studies were conducted to investigate the role of dermal exposure to perfluorooctanoic acid (PFOA), a known immunosuppressant, on the hypersensitivity response to ovalbumin (OVA) in a murine model of asthma. PFOA has had widespread use as a carpet and fabric protectant. BALB/c mice were exposed dermally, on the dorsal surface of each ear, to concentrations of PFOA ranging from 0.01 to 1.5% (applied dose 0.25-50 mg/kg) for 4 days. In hypersensitivity studies, mice were also ip injected with 7.5 microg OVA and 2 mg alum on days 1 and 10 and in some studies challenged with 250 microg OVA by pharyngeal aspiration on days 17 and 26. Following exposure to PFOA, an increase in liver weights and a decrease in thymus and spleen weights and cellularities were observed. Similar immunomodulatory trends were demonstrated in mice coadministered PFOA and OVA. Compared to the OVA alone-exposed animals, an increase in total IgE was demonstrated when mice were coexposed to OVA and concentrations of PFOA ranging from 0.75 to 1.5%, while the OVA-specific IgE response peaked with 0.75% PFOA coexposure (p < or = 0.05). OVA-specific airway hyperreactivity was increased in the 1.0% PFOA coexposed group (p < or = 0.05), with an increased pleiotropic cell response characterized by eosinophilia and mucin production, in animals coexposed to concentrations of PFOA up to 1.0%, as compared to the OVA alone-exposed animals. In a murine model, PFOA was demonstrated to be immunotoxic following dermal exposure, with an enhancement of the hypersensitivity response to OVA, suggesting that PFOA exposure may augment the IgE response to environmental allergens.
JF  - Toxicological sciences : an official journal of the Society of Toxicology
AU  - Fairley, Kimberly J
AU  - Purdy, Rich
AU  - Kearns, Shaun
AU  - Anderson, Stacey E
AU  - Meade, B  J
AD  - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 375
EP  - 383
VL  - 97
IS  - 2
SN  - 1096-6080, 1096-6080
KW  - Antigens
KW  - 0
KW  - Caprylates
KW  - Fluorocarbons
KW  - Immunosuppressive Agents
KW  - Immunoglobulin E
KW  - 37341-29-0
KW  - Ovalbumin
KW  - 9006-59-1
KW  - perfluorooctanoic acid
KW  - 947VD76D3L
KW  - Index Medicus
KW  - Animals
KW  - Hypersensitivity -- physiopathology
KW  - Dose-Response Relationship, Drug
KW  - Respiratory Hypersensitivity -- pathology
KW  - Mice
KW  - Asthma -- chemically induced
KW  - Lung -- pathology
KW  - Mice, Inbred BALB C
KW  - Asthma -- physiopathology
KW  - Phenotype
KW  - Respiratory Hypersensitivity -- physiopathology
KW  - Body Weight -- drug effects
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Antigens -- immunology
KW  - Administration, Topical
KW  - Asthma -- pathology
KW  - Female
KW  - Organ Size -- drug effects
KW  - Ovalbumin -- immunology
KW  - Fluorocarbons -- pharmacology
KW  - Bronchial Hyperreactivity -- chemically induced
KW  - Immunoglobulin E -- immunology
KW  - Immunoglobulin E -- blood
KW  - Bronchial Hyperreactivity -- physiopathology
KW  - Immunoglobulin E -- biosynthesis
KW  - Caprylates -- pharmacology
KW  - Bronchial Hyperreactivity -- pathology
KW  - Immunosuppressive Agents -- pharmacology
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-08-06
N1  - Date created - 2007-05-22
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Simulated workplace protection factors for half-facepiece respiratory protective devices.
AN  - 70457739; 17474032
AB  - This study investigates two different methods (random effects model and 5th percentile) for determining the performance of three types of respiratory protective devices (elastomeric N95 respirators, N95 filtering-facepiece respirators, and surgical masks) during a simulated workplace test. This study recalculated the protection level of three types of respiratory protective devices using the random effects model, compared the two methods with each other and the APF of 10 for half-facepiece respirators, and determined the value of each of the fit test protocols in attaining the desired level of simulated workplace protection factor (SWPF). Twenty-five test subjects with varying face sizes tested 15 models of elastomeric N95 respirators, 15 models of N95 filtering-facepiece respirators, and 6 models of surgical masks. Simulated workplace testing was conducted using a TSI PORTACOUNT Plus model 8020 and consisted of a series of seven exercises. Six simulated workplace tests were performed with redonning of the respirator/mask occurring between each test. Each of the six tests produced an SWPF. To determine the level of protection provided by the respiratory protective devices, a 90% lower confidence limit for the simulated workplace protection factor (SWPF(LCL90%)) and the 5th percentile of simulated workplace protection factor were computed. The 5th percentile method values could be up to seven times higher than the SWPF(LCL90%) values. Without fit testing, all half-facepiece N95 respirators had a 5th percentile of 4.6 and an SWPF(LCL90%) value of 2.7. N95 filtering-facepiece respirators as a class had values of 3.3 and 2.0, respectively, whereas N95 elastomeric respirators had values of 7.3 and 4.6, respectively. Surgical masks did not provide any protection, with values of 1.2 and 1.4, respectively. Passing either the Bitrex, saccharin, or Companion fit test resulted in the respirators providing the expected level of protection with 5th percentiles greater than or equal to 10 except when passing the Bitrex test with N95 filtering-facepiece respirators, which resulted in a 5th percentile of only 7.9. No substantial difference was seen between the three fit tests. All of the SWPF(LCL90%) values after passing a fit test were less than 10. The random model method provides a more conservative estimate of the protection provided by a respirator because it takes into account both between- and within-wearer variability.
JF  - Journal of occupational and environmental hygiene
AU  - Duling, Matthew G
AU  - Lawrence, Robert B
AU  - Slaven, James E
AU  - Coffey, Christopher C
AD  - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA. mwd1@cdc.gov
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 420
EP  - 431
VL  - 4
IS  - 6
SN  - 1545-9624, 1545-9624
KW  - Index Medicus
KW  - Equipment Failure Analysis
KW  - Humans
KW  - Adult
KW  - Models, Statistical
KW  - Middle Aged
KW  - Workplace
KW  - Male
KW  - Female
KW  - Environmental Monitoring -- instrumentation
KW  - Occupational Exposure -- prevention & control
KW  - Respiratory Protective Devices -- standards
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-07-30
N1  - Date created - 2007-05-02
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin B6.
AN  - 70413252; 17374475
AB  - We previously demonstrated that high doses of environmental cigarette smoke (ECS) induce alopecia in mice. This effect was prevented by the oral administration of N-acetylcysteine (NAC), an analogue and precursor of L-cysteine and reduced glutathione.
          The present study aimed at assessing whether L-cystine, the oxidized form of L-cysteine, which is a key hair component, may behave like NAC in inhibiting ECS-induced alopecia and modulating the mechanisms responsible for this condition. C57BL/6 mice were exposed whole-body to ECS in a smoking machine. Groups of mice received in the diet, at three dose levels, a mixture of L-cystine with vitamin B6, which plays a role in L-cystine incorporation in hair cells. Occurrence of alopecia areas and apoptosis of hair bulb cells were evaluated for up to 6 months of exposure, and the time course induction of micronucleated erythrocytes in peripheral blood was investigated. The frequency of micronucleated erythrocytes was increased by ECS, irrespective of treatment with L-cystine/vitamin B6. ECS-induced alopecia and apoptosis of hair bulb cells in all exposed mice. L-Cystine/vitamin B6 inhibited alopecia in a dose-dependent fashion.
          High-dose ECS induces apoptosis-related alopecia in mice, and oral administration of L-cystine/vitamin B6 is an effective preventive treatment.
JF  - Journal of dermatological science
AU  - D'Agostini, Francesco
AU  - Fiallo, Paolo
AU  - Pennisi, Tanya M
AU  - De Flora, Silvio
AD  - Section of Hygiene and Preventive Medicine, Department of Health Sciences, University of Genoa, Via A. Pastore 1, I-16132 Genoa, Italy. fda@unige.it
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 189
EP  - 198
VL  - 46
IS  - 3
SN  - 0923-1811, 0923-1811
KW  - Tobacco Smoke Pollution
KW  - 0
KW  - Cystine
KW  - 48TCX9A1VT
KW  - Vitamin B 6
KW  - 8059-24-3
KW  - Acetylcysteine
KW  - WYQ7N0BPYC
KW  - Index Medicus
KW  - Body Weight
KW  - Administration, Oral
KW  - Animals
KW  - Hair Follicle -- pathology
KW  - Apoptosis
KW  - Hair Follicle -- metabolism
KW  - Dose-Response Relationship, Drug
KW  - Acetylcysteine -- administration & dosage
KW  - Mice, Inbred C57BL
KW  - Mice
KW  - Acetylcysteine -- pharmacology
KW  - Female
KW  - Cystine -- metabolism
KW  - Alopecia -- pathology
KW  - Cystine -- pharmacology
KW  - Alopecia -- etiology
KW  - Vitamin B 6 -- administration & dosage
KW  - Tobacco Smoke Pollution -- adverse effects
KW  - Chemoprevention -- methods
KW  - Cystine -- administration & dosage
KW  - Alopecia -- prevention & control
KW  - Vitamin B 6 -- pharmacology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+dermatological+science&rft.atitle=Chemoprevention+of+smoke-induced+alopecia+in+mice+by+oral+administration+of+L-cystine+and+vitamin+B6.&rft.au=D%27Agostini%2C+Francesco%3BFiallo%2C+Paolo%3BPennisi%2C+Tanya+M%3BDe+Flora%2C+Silvio&rft.aulast=D%27Agostini&rft.aufirst=Francesco&rft.date=2007-06-01&rft.volume=46&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Journal+of+dermatological+science&rft.issn=09231811&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-07-03
N1  - Date created - 2007-04-23
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Noninvasive assessment of cytokines in occupational respiratory diseases.
AN  - 70146158; 19075972
AB  - A major goal in studying occupational respiratory diseases is to show relationships between occupational exposures and health outcomes. Due to the nature of these diseases, accurate, practical, and objective measurement techniques are needed in field investigations. Pulmonary function tests, such as spirometry, are important objective health outcome measures. However, they reflect the functional changes of the lung, often in relatively late stages, which may be irreversible. Direct monitoring of airways inflammations, in response to occupational exposures, are receiving an increasing attention since they may pick up inflammatory changes before the injury becomes irreversible. Invasive approaches such as bronchoalveolar lavage and bronchial biopsies have been used to assess airways inflammation: but these methods are not practical for use in occupational field investigations. Thus, much work has focused on the development of noninvasive methods for monitoring inflammation in occupational respiratory diseases. The three recent most commonly used noninvasive techniques in occupational respiratory diseases investigations are induced sputum, exhaled breath condensate, and nasal lavage. In this review, we discuss the practical application of these techniques, patents and cytokines measured with them. Since variation of cytokine genes contribute to the inflammatory processes, we briefly discuss the genetic polymorphisms on the expression of occupational respiratory diseases. Details of genetic polymorphism were beyond the focus of this review. Our primary focus was cytokines measured with these three noninvasive techniques in occupational respiratory investigations.
JF  - Recent patents on inflammation & allergy drug discovery
AU  - Akpinar-Elci, Muge
AU  - Yucesoy, Berran
AU  - Elci, Omur Cinar
AU  - Weissman, David N
AD  - CDC/NIOSH Division of Respiratory Diseases Studies, Morgantown WV, USA. akpinarelcim@ecu.edu
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 100
EP  - 107
VL  - 1
IS  - 2
SN  - 1872-213X, 1872-213X
KW  - Cytokines
KW  - 0
KW  - Index Medicus
KW  - Sputum -- chemistry
KW  - Inflammation -- physiopathology
KW  - Polymorphism, Genetic
KW  - Humans
KW  - Breath Tests -- methods
KW  - Inflammation -- genetics
KW  - Gene Expression Regulation
KW  - Patents as Topic
KW  - Nasal Lavage Fluid -- chemistry
KW  - Inflammation -- diagnosis
KW  - Occupational Diseases -- diagnosis
KW  - Cytokines -- analysis
KW  - Occupational Diseases -- genetics
KW  - Cytokines -- genetics
KW  - Respiratory Tract Diseases -- diagnosis
KW  - Respiratory Tract Diseases -- genetics
KW  - Occupational Diseases -- physiopathology
KW  - Cytokines -- metabolism
KW  - Respiratory Tract Diseases -- physiopathology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+patents+on+inflammation+%26+allergy+drug+discovery&rft.atitle=Noninvasive+assessment+of+cytokines+in+occupational+respiratory+diseases.&rft.au=Akpinar-Elci%2C+Muge%3BYucesoy%2C+Berran%3BElci%2C+Omur+Cinar%3BWeissman%2C+David+N&rft.aulast=Akpinar-Elci&rft.aufirst=Muge&rft.date=2007-06-01&rft.volume=1&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Recent+patents+on+inflammation+%26+allergy+drug+discovery&rft.issn=1872213X&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2009-03-02
N1  - Date created - 2008-12-16
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Medical toxicology and public health--update on research and activities at the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry.
AN  - 69057803; 18074626
JF  - Journal of medical toxicology : official journal of the American College of Medical Toxicology
AU  - Schier, Joshua
AU  - Algren, Adam
AD  - US Public Health Service, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, USA.
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 85
VL  - 3
IS  - 2
SN  - 1556-9039, 1556-9039
KW  - Fentanyl
KW  - UF599785JZ
KW  - Index Medicus
KW  - United States
KW  - Public Health
KW  - Centers for Disease Control and Prevention (U.S.)
KW  - Humans
KW  - Disease Outbreaks
KW  - Fentanyl -- poisoning
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+toxicology+%3A+official+journal+of+the+American+College+of+Medical+Toxicology&rft.atitle=Medical+toxicology+and+public+health--update+on+research+and+activities+at+the+Centers+for+Disease+Control+and+Prevention+and+the+Agency+for+Toxic+Substances+and+Disease+Registry.&rft.au=Schier%2C+Joshua%3BAlgren%2C+Adam&rft.aulast=Schier&rft.aufirst=Joshua&rft.date=2007-06-01&rft.volume=3&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+toxicology+%3A+official+journal+of+the+American+College+of+Medical+Toxicology&rft.issn=15569039&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-01-03
N1  - Date created - 2007-12-12
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Divergent roles for tumor necrosis factor-alpha in the brain.
AN  - 68542302; 18040839
AB  - Proinflammatory cytokines and chemokines have been implicated in the pathogenesis of several neurological and neurodegenerative disorders. Prominent among such factors is the pleiotropic cytokine, tumor necrosis factor (TNF)-alpha. Under normal physiological conditions, TNF-alpha orchestrates a diverse array of functions involved in immune surveillance and defense, cellular homeostasis, and protection against certain neurological insults. However, paradoxical effects of this cytokine have been observed. TNF-alpha is elicited in the brain following injury (ischemia, trauma), infection (HIV, meningitis), neurodegeneration (Alzheimer's, Parkinson's), and chemically induced neurotoxicity. The multifarious identity for this cytokine appears to be influenced by several mechanisms. Among the most prominent are the regulation of TNFalpha-induced NF-kappaB activation by adapter proteins such as TRADD and TRAF, and second, the heterogeneity of microglia and their distribution pattern across brain regions. Here, we review the differential role of TNF-alpha in response to brain injury, with emphasis on neurodegeneration, and discuss the possible mechanisms for such diverse and region-specific effects.
JF  - Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
AU  - Sriram, Krishnan
AU  - O'Callaghan, James P
AD  - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, CDC-NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA.
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 140
EP  - 153
VL  - 2
IS  - 2
KW  - Inflammation Mediators
KW  - 0
KW  - Tumor Necrosis Factor-alpha
KW  - Index Medicus
KW  - Immunologic Surveillance -- immunology
KW  - Animals
KW  - Homeostasis -- immunology
KW  - Humans
KW  - Immunity, Cellular -- immunology
KW  - Inflammation Mediators -- toxicity
KW  - Tumor Necrosis Factor-alpha -- toxicity
KW  - Brain Chemistry -- immunology
KW  - Brain Injuries -- immunology
KW  - Inflammation Mediators -- adverse effects
KW  - Tumor Necrosis Factor-alpha -- physiology
KW  - Tumor Necrosis Factor-alpha -- adverse effects
KW  - Brain Injuries -- prevention & control
KW  - Inflammation Mediators -- physiology
KW  - Brain Injuries -- pathology
KW  - Brain Injuries -- metabolism
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroimmune+pharmacology+%3A+the+official+journal+of+the+Society+on+NeuroImmune+Pharmacology&rft.atitle=Divergent+roles+for+tumor+necrosis+factor-alpha+in+the+brain.&rft.au=Sriram%2C+Krishnan%3BO%27Callaghan%2C+James+P&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2007-06-01&rft.volume=2&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroimmune+pharmacology+%3A+the+official+journal+of+the+Society+on+NeuroImmune+Pharmacology&rft.issn=1557-1904&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2008-02-25
N1  - Date created - 2007-11-27
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - JOUR
T1  - Evaluation of a proposed velocity equation for improved exothermic process control.
AN  - 68193951; 17519275
AB  - Exothermic or heated processes create potentially unsafe work environments for an estimated 5-10 million American workers each year. Excessive heat and process contaminants have the potential to cause adverse health effects in exposed workers. Owing to the potential hazards, engineering controls are recommended for these processes. Our understanding of heat transfer and meteorological theories, and their applications for engineering controls have evolved since seminal work was published by Hemeon in 1955. These refined theories were reviewed and used to develop a proposed equation to estimate buoyant plume mean velocity. Mean velocity is a key parameter used to estimate the plume volumetric flow required for controlling effluents from exothermic processes. Subsequent to developing the proposed equation, plume velocity data were collected with a thermal anemometer for a model exothermic process in the laboratory, and an actual exothermic process in the field. Laboratory and field results were then compared to solutions provided by the proposed, American Conference of Governmental Industrial Hygienists (ACGIH), and Hemeon mean velocity equations. To determine which equation most closely matched the laboratory and field data, either t-tests or Wilcoxon Signed Rank tests were conducted (based on examination of data normality) to determine the difference between collected data and solutions from the proposed, ACGIH, and Hemeon equations. Median differences and P-values from Wilcoxon Signed Rank tests (nonparametric) indicate that the ACGIH mean velocity equation provides significantly different estimates from the laboratory and the field mean velocity data. However, the proposed and Hemeon equation provided solutions that were not significantly different from the collected data. These results were unexpected due to the similar developmental backgrounds between the ACGIH and Hemeon equations. Findings indicate that radiant heat flux is an important consideration when using horizontal plate heat transfer equations to estimate plume mean velocity over the range of parameters investigated. Results indicate that the mean velocity equation currently recommended by ACGIH is not as accurate as either the proposed or Hemeon equations over the range of parameters investigated.
JF  - The Annals of occupational hygiene
AU  - McKernan, John L
AU  - Ellenbecker, Michael J
AU  - Holcroft, Christina A
AU  - Petersen, Martin R
AD  - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluation and Field Studies, 4676 Columbia Parkway, MS-R14, Cincinnati, OH 45226, USA. JMcKernan@cdc.gov
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 357
EP  - 369
VL  - 51
IS  - 4
SN  - 0003-4878, 0003-4878
KW  - Index Medicus
KW  - Occupational Exposure
KW  - Engineering
KW  - Humans
KW  - Ventilation
KW  - Hot Temperature -- adverse effects
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date completed - 2007-12-18
N1  - Date created - 2007-08-23
N1  - Date revised - 2017-01-13
N1  - Last updated - 2017-01-18
ER  - 



TY  - BOOK
T1  - Preventing Fire Fighter Fatalities Due to Heart Attacks and Other Sudden Cardiovascular Events
AN  - 58757082; 2007-23622
AB  - The National Institute for Occupational Safety and Health (NIOSH) requests assistance in preventing on-duty cardiovascular deaths among U.S. fire fighters. To reduce these deaths, NIOSH recommends that fire departments and fire fighters follow established medical screening guidelines, adopt risk reduction measures during fire fighting operations, and develop and participate in comprehensive wellness/fitness programs. To bring the information and recommendations in this Alert to the attention of the fire service community, NIOSH requests help from the following individuals and organizations: fire commissioners, fire chiefs, State and local fire district administrators, State fire marshals, safety and health officials, health care providers (physicians, nurses, etc.), human resource specialists, unions, labor organizations, insurance companies and editors of trade journals and other publications. Figures.
JF  - United States National Institute for Occupational Safety and Health (NIOSH), Jun 2007, 32 pp.
AU  - Baldwin, Tommy
AU  - Hales, Thomas
AU  - Jackson, Scott
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
EP  - 32p
PB  - United States National Institute for Occupational Safety and Health (NIOSH)
KW  - Social conditions and policy - Public safety and security
KW  - Health conditions and policy - Diseases and disorders
KW  - Firefighters - Physical and mental fitness
KW  - Heart disease - Prevention
KW  - United States - National institute of occupational safety and health
KW  - book
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58757082?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Baldwin%2C+Tommy%3BHales%2C+Thomas%3BJackson%2C+Scott&rft.aulast=Baldwin&rft.aufirst=Tommy&rft.date=2007-06-01&rft.volume=&rft.issue=&rft.spage=32p&rft.isbn=&rft.btitle=Preventing+Fire+Fighter+Fatalities+Due+to+Heart+Attacks+and+Other+Sudden+Cardiovascular+Events&rft.title=Preventing+Fire+Fighter+Fatalities+Due+to+Heart+Attacks+and+Other+Sudden+Cardiovascular+Events&rft.issn=&rft_id=info:doi/
L2  - http://www.cdc.gov/niosh/docs/2007-133/pdfs/2007-133.pdf
LA  - English
DB  - PAIS Index
N1  - Date revised - 2007-12-07
N1  - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2007
N1  - Last updated - 2016-09-28
ER  - 



TY  - JOUR
T1  - Challenges in Replicating Interventions
AN  - 57076038; 200720161
AB  - Purpose To describe and reflect on an effort to document, through a set of 6 interventions, the process of adapting effective youth risk behavior interventions for new settings, and to provide insights into how this might best be accomplished. Methods Six studies were funded by the NIH, starting in 1999. The studies were funded in response to a Request for Applications (RFA) to replicate HIV prevention interventions for youth. Researchers were to select an HIV risk reduction intervention program shown to be effective in one adolescent population and to replicate it in a new community or different adolescent population. This was to be done while systematically documenting those processes and aspects of the intervention hypothesized to be critical to the development of community-based, culturally sensitive programs. The replication was to assess the variations necessary to gain cooperation, implement a locally feasible and meaningful intervention, and evaluate the outcomes in the new setting. The rationale for this initiative and description of the goals and approaches to adaptation of the funded researchers are described. Results Issues relevant to all interventions are discussed, in addition to those unique to replication. The processes and the consequences of the adaptations are then discussed. The further challenges in taking a successful intervention 'to scale' are not discussed. Conclusions Replications of effective interventions face all of the challenges of implementation design, plus additional challenges of balancing fidelity to the original intervention and sensitivity to the needs of new populations. [Copyright 2007 The Society for Adolescent Medicine; published by Elsevier Inc.]
JF  - Journal of Adolescent Health
AU  - Bell, Stephanie G
AU  - Newcomer, Susan F
AU  - Bachrach, Christine
AU  - Borawski, Elaine
AU  - Jemmott, John B, III
AU  - Morrison, Diane
AU  - Stanton, Bonita
AU  - Tortolero, Susan
AU  - Zimmerman, Richard
AD  - Agency for Healthcare Research and Quality, Rockville, Maryland
Y1  - 2007/06//
PY  - 2007
DA  - June 2007
SP  - 514
EP  - 520
PB  - Elsevier, New York NY
VL  - 40
IS  - 6
SN  - 1054-139X, 1054-139X
KW  - Adolescents
KW  - Interventions
KW  - Sexual behavior
KW  - HIV risk
KW  - Health risks
KW  - Sexual behaviour
KW  - Risk behaviour
KW  - HIV
KW  - article
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57076038?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Challenges+in+Replicating+Interventions&rft.au=Bell%2C+Stephanie+G%3BNewcomer%2C+Susan+F%3BBachrach%2C+Christine%3BBorawski%2C+Elaine%3BJemmott%2C+John+B%2C+III%3BMorrison%2C+Diane%3BStanton%2C+Bonita%3BTortolero%2C+Susan%3BZimmerman%2C+Richard&rft.aulast=Bell&rft.aufirst=Stephanie&rft.date=2007-06-01&rft.volume=40&rft.issue=6&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2006.09.005
LA  - English
DB  - Applied Social Sciences Index & Abstracts (ASSIA)
N1  - Date revised - 2007-12-10
N1  - Last updated - 2016-09-27
N1  - CODEN - JAHCD9
N1  - SubjectsTermNotLitGenreText - Adolescents; Interventions; Risk behaviour; Health risks; HIV; Sexual behaviour
DO  - http://dx.doi.org/10.1016/j.jadohealth.2006.09.005
ER  - 



TY  - JOUR
T1  - A probabilistic framework for non-cancer risk assessment
AN  - 20850370; 8253472
AB  - Risk assessment involves an analysis of the relationship between exposure and health related outcomes to derive an allowable exposure level or to estimate a low-dose risk. Acceptable levels of human exposure for non-cancer effects generally are derived by dividing an experimental no-observed-adverse-effect-level or a lower confidence limit benchmark dose by a product of several uncertainty factors. This paper presents a hierarchical modeling framework for a probabilistic approach to non-cancer risk assessment. The hierarchical model integrates the distributions of uncertainty factors and the distribution of the actual exposure level to construct the dose-response model for the proportion of population at risk and the dose-response model for the expected proportion of population at risk for a given exposure distribution. The proposed approach is based on the use of the BMDL (lower confidence limit on the benchmark dose) as a POD (point of departure) for risk assessment of non-cancer effects.
JF  - Regulatory Toxicology and Pharmacology
AU  - Chen, J J
AU  - Moon, H
AU  - Kodell, R L
AD  - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA, jchen@nctr.fda.gov
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 45
EP  - 50
PB  - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 48
IS  - 1
SN  - 0273-2300, 0273-2300
KW  - Toxicology Abstracts; Risk Abstracts
KW  - Risk assessment
KW  - benchmarks
KW  - Dose-response effects
KW  - Risk factors
KW  - Models
KW  - X 24310:Pharmaceuticals
KW  - R2 23060:Medical and environmental health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20850370?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=A+probabilistic+framework+for+non-cancer+risk+assessment&rft.au=Chen%2C+J+J%3BMoon%2C+H%3BKodell%2C+R+L&rft.aulast=Chen&rft.aufirst=J&rft.date=2007-06-01&rft.volume=48&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2006.10.008
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Risk assessment; Risk factors; Models; benchmarks; Dose-response effects
DO  - http://dx.doi.org/10.1016/j.yrtph.2006.10.008
ER  - 



TY  - JOUR
T1  - Behavioral effects associated with chronic ketamine or remacemide exposure in rats
AN  - 20845234; 8253002
AB  - The effects of chronic exposure to ketamine or remacemide on the acquisition and performance of food-reinforced operant behaviors was assessed in female Sprague-Dawley rats. Ketamine is an anesthetic N-methyl-d-aspartate (NMDA) receptor antagonist, whereas remacemide is an active central nervous system compound with both NMDA receptor antagonist and sodium channel blocking properties. Learning, audio/visual discrimination and motivation were modeled using incremental repeated acquisition (IRA), audio/visual discrimination (AVD) and progressive ratio (PR) tasks, respectively. Ketamine (10 or 100 mg/kg/day), remacemide (100 or 150 mg/kg/day) or water was administered daily (7 days/week) via orogastric gavage beginning on postnatal day (PND) 23 and continuing until PND 257. Monday through Friday behavioral assessments began on PND 27 and continued until PND 383. Chronic treatment with the high dose of ketamine decreased response rate in all tasks suggesting decreased motivation or motoric capabilities. Chronic treatment with ketamine or remacemide had no effect on the acquisition of IRA task performance at any dose tested. While chronic treatment with either high-dose ketamine or low-dose remacemide only delayed the acquisition of AVD task performance for a brief period midway through treatment, chronic treatment with high-dose remacemide delayed the acquisition of AVD task performance until late in treatment. The findings for ketamine are quite different from those of MK-801 (the prototypic NMDA receptor antagonist) in a previous rat study in which MK-801 severely disrupted the acquisition of both IRA and AVD task performances. These observations suggest important differences in the mechanism of action between ketamine and MK-801. For example, ketamine has a much lower binding affinity than MK-801 for the NMDA receptor, the dopamine transporter and the dopamine D2 receptor. In addition, the findings for remacemide observed in rats are in marked contrast with those seen in monkeys where chronic remacemide had profound disruptive effects on the acquisition of both IRA and AVD task performances and suggest important species differences.
JF  - Neurotoxicology and Teratology
AU  - Wright, LKM
AU  - Pearson, E C
AU  - Hammond, T G
AU  - Paule, M G
AD  - National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079-9502, USA, merle.paule@fda.hhs.gov
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 348
EP  - 359
PB  - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com]
VL  - 29
IS  - 3
SN  - 0892-0362, 0892-0362
KW  - Toxicology Abstracts; CSA Neurosciences Abstracts
KW  - Dopamine D2 receptors
KW  - Central nervous system
KW  - N-Methyl-D-aspartic acid receptors
KW  - Motivation
KW  - Receptor mechanisms
KW  - Operant conditioning
KW  - Food
KW  - Anesthetics
KW  - Glutamic acid receptors
KW  - MK-801
KW  - Glutamic acid receptors (ionotropic)
KW  - Visual discrimination learning
KW  - Dopamine transporter
KW  - Chronic exposure
KW  - Ketamine
KW  - Sodium channels
KW  - Visual discrimination
KW  - X 24310:Pharmaceuticals
KW  - N3 11028:Neuropharmacology & toxicology
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20845234?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Behavioral+effects+associated+with+chronic+ketamine+or+remacemide+exposure+in+rats&rft.au=Wright%2C+LKM%3BPearson%2C+E+C%3BHammond%2C+T+G%3BPaule%2C+M+G&rft.aulast=Wright&rft.aufirst=LKM&rft.date=2007-06-01&rft.volume=29&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2006.12.004
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-07-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Central nervous system; N-Methyl-D-aspartic acid receptors; Operant conditioning; Receptor mechanisms; Motivation; Food; Anesthetics; Glutamic acid receptors; Glutamic acid receptors (ionotropic); MK-801; Visual discrimination learning; Dopamine transporter; Chronic exposure; Ketamine; Sodium channels; Visual discrimination
DO  - http://dx.doi.org/10.1016/j.ntt.2006.12.004
ER  - 



TY  - JOUR
T1  - Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer
AN  - 20651412; 8079390
AB  - We have previously reported significant inverse associations between bladder cancer risk and dietary intake of vitamins B2, B6, B12, folate and protein in a hospital-based bladder cancer case-control study conducted in Spain (1,150 cases; 1,149 controls). Because these dietary factors are involved in the one-carbon metabolism pathway, we evaluated associations between bladder cancer risk and 33 single nucleotide polymorphisms (SNPs) in 8 genes (CBS, CTH, MTHFR, MTR, MTRR, SHMT1, SLC19A1 and TYMS) and interactions with dietary variables involved in this pathway. Two SNPs in the CTH gene were significantly associated with bladder cancer risk. OR (95% CI) for heterozygous and the homozygous variants compared to homozygous wild-type individuals were: 1.37 (1.04-1.80) IVS3-66 A > C and 1.22 (1.02-1.45) IVS10-430 C > T. Because the CTH gene is important for glutathione synthesis, we examined interactions with the GSTM1 gene, which codes for glutathione S-transferase u. Increased risk for individuals with the IVS10-430 CT or TT genotype was limited to those with the GSTM1 null genotype (p-interaction = 0.02). No other SNPs were associated with risk of bladder cancer. These findings suggest that common genetic variants in the one-carbon pathway may not play an important role in the etiology of bladder cancer. However, our results provide some evidence that variation in glutathione synthesis may contribute to risk, particularly among individuals who carry a deletion in GSTM1. Additional work is needed to comprehensively evaluate genomic variation in CTH and related genes in the trans-sulfuration pathway and bladder cancer risk.
JF  - International Journal of Cancer
AU  - Moore, Lee E
AU  - Malats, Nuria
AU  - Rothman, Nathaniel
AU  - Real, Francisco X
AU  - Kogevinas, Manolis
AU  - Karami, Sara
AU  - Garcia-Closas, Reina
AU  - Silverman, Debra
AU  - Chanock, Stephen
AU  - Welch, Robert
AU  - Tardon, Adonina
AU  - Serra, Consol
AU  - Carrato, Alfredo
AU  - Dosemeci, Mustafa
AU  - Garcia-Closas, Montserrat
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, moorele@mail.nih.gov
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 2452
EP  - 2458
PB  - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/]
VL  - 120
IS  - 11
SN  - 0020-7136, 0020-7136
KW  - Genetics Abstracts; Risk Abstracts
KW  - Spain
KW  - Gene polymorphism
KW  - Vitamin B6
KW  - Methylenetetrahydrofolate reductase
KW  - Genotypes
KW  - Glutathione transferase
KW  - Dietary intake
KW  - GSTM1 protein
KW  - vitamins
KW  - genomics
KW  - Folic acid
KW  - GSTM1 gene
KW  - Diets
KW  - Etiology
KW  - Urinary bladder
KW  - Ingestion
KW  - Cancer
KW  - Vitamin B12
KW  - Single-nucleotide polymorphism
KW  - Proteins
KW  - Metabolism
KW  - G 07880:Human Genetics
KW  - R2 23060:Medical and environmental health
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Polymorphisms+in+one-carbon+metabolism+and+trans-sulfuration+pathway+genes+and+susceptibility+to+bladder+cancer&rft.au=Moore%2C+Lee+E%3BMalats%2C+Nuria%3BRothman%2C+Nathaniel%3BReal%2C+Francisco+X%3BKogevinas%2C+Manolis%3BKarami%2C+Sara%3BGarcia-Closas%2C+Reina%3BSilverman%2C+Debra%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BDosemeci%2C+Mustafa%3BGarcia-Closas%2C+Montserrat&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2007-06-01&rft.volume=120&rft.issue=11&rft.spage=2452&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22565
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Etiology; Urinary bladder; Gene polymorphism; Vitamin B6; Methylenetetrahydrofolate reductase; Glutathione transferase; Dietary intake; Cancer; GSTM1 protein; Vitamin B12; Single-nucleotide polymorphism; genomics; Folic acid; GSTM1 gene; Metabolism; Diets; vitamins; Proteins; Genotypes; Ingestion; Spain
DO  - http://dx.doi.org/10.1002/ijc.22565
ER  - 



TY  - JOUR
T1  - Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity
AN  - 20479453; 8017914
AB  - Nanoparticles agglomerate and clump in solution, making it difficult to accurately deliver them for in vivo or in vitro experiments. Thus, experiments were conducted to determine the best method to suspend nanosized particles. Ultrafine and fine carbon black and titanium dioxide were suspended in phosphate buffered saline (PBS), rat and mouse bronchoalveolar lavage fluid (BALF), and PBS containing dipalmitoyl phosphatidylcholine (DPPC) and/or mouse serum albumin. To assess and compare how these various suspension media dispersed the nanoparticles, images were taken using light microscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The results of this study show that PBS is not a satisfactory medium to prepare nanoparticle suspensions. However, BALF was an excellent media in which to suspend nanoparticles. The use of PBS containing protein or DPPC alone, in concentrations found in BALF, did not result in satisfactory particle dispersion. However, PBS-containing protein plus DPPC was satisfactory, although less effective than BALF.
JF  - Nanotoxicology
AU  - Sager, Tina M
AU  - Porter, Dale W
AU  - Robinson, Victor A
AU  - Lindsley, William G
AU  - Schwegler-Berry, Diane E
AU  - Castranova, Vincent
AD  - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 118
EP  - 129
PB  - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk]
VL  - 1
IS  - 2
SN  - 1743-5390, 1743-5390
KW  - Toxicology Abstracts
KW  - Scanning electron microscopy
KW  - Carbon
KW  - Titanium dioxide
KW  - Bronchus
KW  - Phosphate
KW  - Transmission electron microscopy
KW  - Albumin
KW  - Lecithin
KW  - Toxicity
KW  - nanoparticles
KW  - Alveoli
KW  - X 24300:Methods
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20479453?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Improved+method+to+disperse+nanoparticles+for+in+vitro+and+in+vivo+investigation+of+toxicity&rft.au=Sager%2C+Tina+M%3BPorter%2C+Dale+W%3BRobinson%2C+Victor+A%3BLindsley%2C+William+G%3BSchwegler-Berry%2C+Diane+E%3BCastranova%2C+Vincent&rft.aulast=Sager&rft.aufirst=Tina&rft.date=2007-06-01&rft.volume=1&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.1080%2F17435390701381596
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-03-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Scanning electron microscopy; Titanium dioxide; Carbon; Phosphate; Bronchus; Transmission electron microscopy; Albumin; Lecithin; Toxicity; nanoparticles; Alveoli
DO  - http://dx.doi.org/10.1080/17435390701381596
ER  - 



TY  - JOUR
T1  - Selection of differentially expressed genes in microarray data analysis
AN  - 20457159; 7520884
AB  - One common objective in microarray experiments is to identify a subset of genes that express differentially among different experimental conditions, for example, between drug treatment and no drug treatment. Often, the goal is to determine the underlying relationship between poor versus good gene signatures for identifying biological functions or predicting specific therapeutic outcomes. Because of the complexity in studying hundreds or thousands of genes in an experiment, selection of a subset of genes to enhance relationships among the underlying biological structures or to improve prediction accuracy of clinical outcomes has been an important issue in microarray data analysis. Selection of differentially expressed genes is a two-step process. The first step is to select an appropriate test statistic and compute the P-value. The genes are ranked according to their P-values as evidence of differential expression. The second step is to assign a significance level, that is, to determine a cutoff threshold from the P-values in accordance with the study objective. In this paper, we consider four commonly used statistics, t-, S- (SAM), U-(Mann-Whitney) and M-statistics to compute the P-values for gene ranking. We consider the family-wise error and false discovery rate false-positive error-controlled procedures to select a limited number of genes, and a receiver-operating characteristic (ROC) approach to select a larger number of genes for assigning the significance level. The ROC approach is particularly useful in genomic/genetic profiling studies. The well-known colon cancer data containing 22 normal and 40 tumor tissues are used to illustrate different gene ranking and significance level assignment methods for applications to genomic/genetic profiling studies. The P-values computed from the t-, U- and M-statistics are very similar. We discuss the common practice that uses the P-value, false-positive error probability, as the primary criterion, and then uses the fold-change as a surrogate measure of biological significance for gene selection. The P-value and the fold-change can be pictorially shown simultaneously in a volcano plot. We also address several issues on gene selection.
JF  - Pharmacogenomics Journal
AU  - Chen, J J
AU  - Wang, S-J
AU  - Tsai, C-A
AU  - Lin, C-J
AD  - Division of Biometry and Risk Assessment, National Center for Toxicological Research, US Food and Drug Administration, HFT-20, Jefferson, AR 72079, USA, jchen@nctr.fda.gov
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 212
EP  - 220
VL  - 7
IS  - 3
SN  - 1470-269X, 1470-269X
KW  - Biotechnology and Bioengineering Abstracts; Genetics Abstracts
KW  - Data processing
KW  - Training
KW  - genomics
KW  - Colon cancer
KW  - Tumors
KW  - Drugs
KW  - W 30915:Pharmaceuticals & Vaccines
KW  - G 07700:Molecular Genetics
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20457159?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics+Journal&rft.atitle=Selection+of+differentially+expressed+genes+in+microarray+data+analysis&rft.au=Chen%2C+J+J%3BWang%2C+S-J%3BTsai%2C+C-A%3BLin%2C+C-J&rft.aulast=Chen&rft.aufirst=J&rft.date=2007-06-01&rft.volume=7&rft.issue=3&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics+Journal&rft.issn=1470269X&rft_id=info:doi/10.1038%2Fsj.tpj.6500412
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-08-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Data processing; Training; Tumors; Colon cancer; genomics; Drugs
DO  - http://dx.doi.org/10.1038/sj.tpj.6500412
ER  - 



TY  - JOUR
T1  - Tubulin Is a Neuronal Target of Autoantibodies in Sydenham's Chorea
AN  - 19878698; 7419321
AB  - Sydenham's chorea is a CNS disorder and sequela of group A streptococcal infection where deposition of Abs in brain may result in movement and neuropsychiatric abnormalities. We studied human mAbs 24.3.1, 31.1.1, and 37.2.1 derived from chorea and selected for cross-reactivity with group A streptococci and brain Ags. Our novel findings reveal that Sydenham's chorea mAbs target a 55-kDa brain protein with an N-terminal amino acid sequence of MREIVHLQ corresponding to beta -tubulin. Chorea mAb specificity for purified brain tubulin was confirmed in ELISA and Western immunoblot, and significant levels of anti-tubulin IgG were found in acute chorea sera and cerebrospinal fluid. Lysoganglioside G sub(M1) inhibited binding of chorea mAbs to tubulin and mAb reactivity with human caudate and putamen brain sections was blocked by anti-tubulin mAb. The chorea mAbs labeled both intra- and extracellular Ags of a neuronal cell line providing evidence suggesting mimicry between intracellular brain protein tubulin and extracellular lysoganglioside. In addition, chorea mAb 24.3.1 and acute chorea sera induced calcium/calmodulin-dependent protein kinase II activity in human neuronal cells. Nucleotide sequence analysis of the chorea mAb V sub(H) genes revealed that mAb 24.3.1 V sub(H) gene was encoded by the V sub(H)1 germline gene family which encodes other anti-ganglioside V sub(H) genes associated with motor neuropathies. mAb recognition of tubulin and the neuronal cell surface with initiation of cell signaling and dopamine release supports an emerging theme in autoimmunity whereby cross-reactive or polyreactive autoantibodies against intracellular Ags recognize cell surface epitopes potentially leading to disease.
JF  - Journal of Immunology
AU  - Kirvan, Christine A
AU  - Cox, Carol J
AU  - Swedo, Susan E
AU  - Cunningham, Madeleine W
AD  - Department of Biological Sciences, California State University, Sacramento, CA 95819. Department of Microbiology and Immunology, University of Oklahoma, Oklahoma, City, OK 73104. Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892
Y1  - 2007/06/01/
PY  - 2007
DA  - 2007 Jun 01
SP  - 7412
EP  - 7421
PB  - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/]
VL  - 178
IS  - 11
SN  - 0022-1767, 0022-1767
KW  - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; CSA Neurosciences Abstracts
KW  - Cell surface
KW  - Central nervous system
KW  - Cross-reactivity
KW  - Calcium
KW  - Nucleotide sequence
KW  - Autoimmune diseases
KW  - Infection
KW  - Putamen
KW  - Mental disorders
KW  - Cerebrospinal fluid
KW  - Dopamine
KW  - Ca super(2+)/calmodulin-dependent protein kinase II
KW  - Epitopes
KW  - Neuropathy
KW  - Streptococcus
KW  - Intracellular signalling
KW  - Mimicry
KW  - Enzyme-linked immunosorbent assay
KW  - Monoclonal antibodies
KW  - Brain
KW  - Chorea
KW  - Autoantibodies
KW  - Ca super(2+)/calmodulin-dependent protein kinase
KW  - Immunoglobulin G
KW  - Tubulin
KW  - Amino acid sequence
KW  - N 14815:Nucleotide Sequence
KW  - J 02350:Immunology
KW  - F 06930:Autoimmunity
KW  - N3 11024:Neuroimmunology
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Tubulin+Is+a+Neuronal+Target+of+Autoantibodies+in+Sydenham%27s+Chorea&rft.au=Kirvan%2C+Christine+A%3BCox%2C+Carol+J%3BSwedo%2C+Susan+E%3BCunningham%2C+Madeleine+W&rft.aulast=Kirvan&rft.aufirst=Christine&rft.date=2007-06-01&rft.volume=178&rft.issue=11&rft.spage=7412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-06-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Central nervous system; Cell surface; Calcium; Cross-reactivity; Nucleotide sequence; Autoimmune diseases; Infection; Putamen; Cerebrospinal fluid; Mental disorders; Dopamine; Ca super(2+)/calmodulin-dependent protein kinase II; Epitopes; Neuropathy; Mimicry; Intracellular signalling; Enzyme-linked immunosorbent assay; Monoclonal antibodies; Brain; Chorea; Autoantibodies; Ca super(2+)/calmodulin-dependent protein kinase; Immunoglobulin G; Tubulin; Amino acid sequence; Streptococcus
ER  - 



TY  - JOUR
T1  - In-cab noise reduction on an air-rotary drill rig
AN  - 19711300; 7520143
AB  - The National Institute for Occupational Safety and Health (NIOSH) has investigated engineering noise controls to reduce sound levels in cabs on air-rotary drill rigs. A recent investigation revealed that some drillers are exposed to A-weighted sound levels exceeding 85 dB even though a cab is used. NIOSH studied the in-cab sound levels of one such rig. First, preliminary tests were conducted in a controlled environment using accelerometers and microphones with spectral analysis to identify the dominant noise sources for in-cab sound levels. The results indicate that vibration transmitted from multiple hydraulic pumps to the control panel produces a dominant spike in the sound level spectrum in the 400 Hz 1/3-octave band. Next, field tests were performed in a production environment to evaluate noise controls to reduce in-cab sound levels. It was found that utilizing hydraulic noise suppressors reduces the structure-borne noise transmitted to the control panel. Further, using hydraulic noise suppressors and enhancing soundproofing reduced the in-cab A-weighted sound levels by as much as 4 dB.
JF  - Noise Control Engineering Journal
AU  - Yantek, D S
AU  - Ingram, D K
AU  - Matetic, R J
AD  - NIOSH Pittsburgh Research Laboratory, P.O. Box 18070, Pittsburgh PA 15236, USA, DYantek@cdc.gov
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 294
EP  - 310
VL  - 55
IS  - 3
SN  - 0736-2501, 0736-2501
KW  - Health & Safety Science Abstracts; Pollution Abstracts
KW  - Hydraulics
KW  - Vibration
KW  - Machinery
KW  - microphones
KW  - accelerometers
KW  - Noise reduction
KW  - Occupational exposure
KW  - P 7000:NOISE
KW  - H 1000:Occupational Safety and Health
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19711300?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+Control+Engineering+Journal&rft.atitle=In-cab+noise+reduction+on+an+air-rotary+drill+rig&rft.au=Yantek%2C+D+S%3BIngram%2C+D+K%3BMatetic%2C+R+J&rft.aulast=Yantek&rft.aufirst=D&rft.date=2007-06-01&rft.volume=55&rft.issue=3&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Noise+Control+Engineering+Journal&rft.issn=07362501&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-08-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Hydraulics; Machinery; Vibration; microphones; accelerometers; Noise reduction; Occupational exposure
ER  - 



TY  - JOUR
T1  - Preventing Excessive Weight Gain in Adolescents: Interpersonal Psychotherapy for Binge Eating
AN  - 19695341; 7464276
AB  - The most prevalent disordered eating pattern described in overweight youth is loss of control (LOC) eating, during which individuals experience an inability to control the type or amount of food they consume. LOC eating is associated cross-sectionally with greater adiposity in children and adolescents and seems to predispose youth to gain weight or body fat above that expected during normal growth, thus likely contributing to obesity in susceptible individuals. No prior studies have examined whether LOC eating can be decreased by interventions in children or adolescents without full-syndrome eating disorders or whether programs reducing LOC eating prevent inappropriate weight gain attributable to LOC eating. Interpersonal psychotherapy, a form of therapy that was designed to treat depression and has been adapted for the treatment of eating disorders, has shown efficacy in reducing binge eating episodes and inducing weight stabilization among adults diagnosed with binge eating disorder. In this paper, we propose a theoretical model of excessive weight gain in adolescents at high risk for adult obesity who engage in LOC eating and associated overeating patterns. A rationale is provided for interpersonal psychotherapy as an intervention to slow the trajectory of weight gain in at-risk youth, with the aim of preventing or ameliorating obesity in adulthood.
JF  - Obesity Research
AU  - Tanofsky-Kraff, Marian
AU  - Wilfley, Denise E
AU  - Young, Jami F
AU  - Mufson, Laura
AU  - Yanovski, Susan Z
AU  - Glasofer, Deborah R
AU  - Salaita, Christine G
AD  - Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Department of Health and Human Services, Bethesda, Maryland. Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Weight Management and Eating Disorders Program, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York. Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 1345
EP  - 1355
PB  - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org]
VL  - 15
IS  - 6
SN  - 1071-7323, 1071-7323
KW  - Physical Education Index
KW  - Obesity
KW  - Programs
KW  - Depression
KW  - Eating disorders
KW  - Adolescence
KW  - Diet (weight control)
KW  - Therapy
KW  - Adults
KW  - Children
KW  - Experience
KW  - Youth
KW  - Self efficacy
KW  - PE 030:Exercise, Health & Physical Fitness
UR  - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19695341?accountid=14244
L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Preventing+Excessive+Weight+Gain+in+Adolescents%3A+Interpersonal+Psychotherapy+for+Binge+Eating&rft.au=Tanofsky-Kraff%2C+Marian%3BWilfley%2C+Denise+E%3BYoung%2C+Jami+F%3BMufson%2C+Laura%3BYanovski%2C+Susan+Z%3BGlasofer%2C+Deborah+R%3BSalaita%2C+Christine+G&rft.aulast=Tanofsky-Kraff&rft.aufirst=Marian&rft.date=2007-06-01&rft.volume=15&rft.issue=6&rft.spage=1345&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/
LA  - English
DB  - Physical Education Index
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Experience; Obesity; Programs; Depression; Eating disorders; Adolescence; Therapy; Diet (weight control); Adults; Children; Youth; Self efficacy
ER  - 



TY  - JOUR
T1  - Birth Weight, Postnatal Growth, and Risk for High Blood Pressure at 7 Years of Age: Results From the Collaborative Perinatal Project
AN  - 19687763; 7464414
AB  - OBJECTIVE. A physiologic predisposition toward hypertension is theorized to result from the combination of intrauterine growth restriction followed by rapid catch-up growth. The objective of this study was to evaluate the effects of birth weight and weight gain during childhood on the risk for high blood pressure in childhood and to identify discrete periods of catch-up growth that put children with intrauterine growth restriction at increased risk for the development of high blood pressure later in life. METHODS. The US Collaborative Perinatal Project (1959-1974) studied 55908 pregnancies in an observational cohort at 12 medical centers in the United States and followed the offspring through 7 years of age. All white or black children who were born at term and completed the follow-up without kidney or heart disease were included in this posthoc analysis. z scores were calculated for weight at birth, 4 months, 1 year, 4 years, and 7 years on the basis of study means and SD. Changes in z scores were calculated for each interval. RESULTS. Each 1-kg increase in birth weight increased the odds for high systolic blood pressure by 2.19 and high diastolic blood pressure by 1.82 when race and change in weight z scores were also included in the regression model. An increase in weight z score of 1 SD above the previous weight z score increased the odds for high systolic blood pressure at 7 years by 1.65 (birth to 4 months), 1.79 (4 months to 1 year), 1.71 (1-4 years), and 1.94 (4-7 years) in the full model. White race increased the odds for high systolic blood pressure by 1.51. CONCLUSIONS. In this large biracial US cohort, infants who were small for gestational age were not at increased risk for high blood pressure at 7 years of age. However, children who crossed weight percentiles upward during early childhood did demonstrate an increased risk.
JF  - Pediatrics
AU  - Hemachandra, Anusha H
AU  - Howards, Penelope P
AU  - Furth, Susan L
AU  - Klebanoff, Mark A
AD  - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Divisions of Neonatology. Pediatric Nephrology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - e1264
EP  - e1270
PB  - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org]
VL  - 119
IS  - 6
SN  - 0031-4005, 0031-4005
KW  - Risk Abstracts
KW  - USA
KW  - Growth
KW  - Age
KW  - low-birth-weight
KW  - hypertension
KW  - Kidney
KW  - birth weight
KW  - Children
KW  - offspring
KW  - Infants
KW  - Pregnancy
KW  - R2 23060:Medical and environmental health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Age; Growth; hypertension; low-birth-weight; Kidney; birth weight; Children; Pregnancy; Infants; offspring; USA
ER  - 



TY  - JOUR
T1  - Comparison of Proliferative and Multilineage Differentiation Potential of Human Mesenchymal Stem Cells Derived from Umbilical Cord and Bone Marrow
AN  - 19687284; 7465189
AB  - Human umbilical cord perivascular cells (HUCPVCs) have been shown to have a high proliferative potential and the capacity to differentiate into an osteogenic phenotype. HUCPVCs have thus been considered a possible extra-embryonic mesenchymal stem cell (MSC) source for cell-based therapies. To assess this potential, we compared HUCPVCs to the "gold standard" bone marrow mesenchymal stromal cells (BMSCs) with respect to their proliferation, differentiation, and transfection capacities. HUCPVCs showed a higher proliferative potential than BMSCs and were capable of osteogenic, chondrogenic, and adipogenic differentiation. Interestingly, osteogenic differentiation of HUCPVCs proceeded more rapidly than BMSCs. Additionally, HUCPVCs expressed higher levels of CD146, a putative MSC marker, relative to BMSCs. HUCPVCs showed comparable transfection efficiency as BMSCs using a nucleofection method but were more amenable to transfection with liposomal methods (FuGENE). Gene array analysis showed that HUCPVCs also expressed Wnt signaling pathway genes that have been implicated in the regulation of MSCs. The similar characteristics between HUCPVCs and MSCs support the applicability of HUCPVCs for cell-based therapies. Disclosure of potential conflicts of interest is found at the end of this article.
JF  - Stem Cells
AU  - Baksh, Dolores
AU  - Yao, Raphael
AU  - Tuan, Rocky S
AD  - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 1384
EP  - 1392
PB  - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA
VL  - 25
IS  - 6
SN  - 1066-5099, 1066-5099
KW  - Biotechnology and Bioengineering Abstracts
KW  - Differentiation
KW  - Stem cells
KW  - Wnt protein
KW  - stromal cells
KW  - Transfection
KW  - Bone marrow
KW  - Mesenchyme
KW  - Cell proliferation
KW  - Umbilical cord
KW  - Signal transduction
KW  - W 30905:Medical Applications
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Comparison+of+Proliferative+and+Multilineage+Differentiation+Potential+of+Human+Mesenchymal+Stem+Cells+Derived+from+Umbilical+Cord+and+Bone+Marrow&rft.au=Baksh%2C+Dolores%3BYao%2C+Raphael%3BTuan%2C+Rocky+S&rft.aulast=Baksh&rft.aufirst=Dolores&rft.date=2007-06-01&rft.volume=25&rft.issue=6&rft.spage=1384&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-07-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Wnt protein; stromal cells; Transfection; Bone marrow; Cell proliferation; Mesenchyme; Umbilical cord; Signal transduction
ER  - 



TY  - JOUR
T1  - Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure
AN  - 19669884; 7430855
AB  - Micro RNAs (miRNAs) are small non-coding RNA molecules that function as negative regulators of gene expression. They play a crucial role in the regulation of genes involved in the control of development, cell proliferation, apoptosis, and stress response. Although miRNA levels are substantially altered in tumors, their role in carcinogenesis, specifically at the early pre-cancerous stages, has not been established. Here we report that exposure of Fisher 344 rats to tamoxifen, a potent hepatocarcinogen in rats, for 24 weeks leads to substantial changes in the expression of miRNA genes in the liver. We noted a significant up-regulation of known oncogenic miRNAs, such as the 17-92 cluster, miR-106a, and miR-34. Furthermore, we confirmed the corresponding changes in the expression of proteins targeted by these miRNAs, which include important cell cycle regulators, chromatin modifiers, and expression regulators implicated in carcinogenesis. All these miRNA changes correspond to previously reported alterations in full-fledged tumors, including hepatocellular carcinomas. Thus, our findings indicate that miRNA changes occur prior to tumor formation and are not merely a consequence of a transformed state.
JF  - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis
AU  - Pogribny, I P
AU  - Tryndyak, V P
AU  - Boyko, A
AU  - Rodriguez-Juarez, R
AU  - Beland, F A
AU  - Kovalchuk, O
AD  - National Center for Toxicological Research, Jefferson, AR 72079, United States, igor.pogribny@fda.hhs.gov
Y1  - 2007/06/01/
PY  - 2007
DA  - 2007 Jun 01
SP  - 30
EP  - 37
PB  - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/]
VL  - 619
IS  - 1-2
SN  - 1386-1964, 1386-1964
KW  - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts
KW  - Molecular modelling
KW  - Apoptosis
KW  - Chromatin
KW  - Cell cycle
KW  - miRNA
KW  - non-coding RNA
KW  - Stress
KW  - Transcription
KW  - Tumors
KW  - Tamoxifen
KW  - Mutagenesis
KW  - Gene expression
KW  - Gene regulation
KW  - Carcinogenesis
KW  - Cell proliferation
KW  - Hepatocellular carcinoma
KW  - X 24310:Pharmaceuticals
KW  - N 14830:RNA
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2007-06-01
N1  - Last updated - 2015-04-01
N1  - SubjectsTermNotLitGenreText - Molecular modelling; Apoptosis; Chromatin; miRNA; Cell cycle; non-coding RNA; Transcription; Stress; Tumors; Tamoxifen; Mutagenesis; Gene expression; Gene regulation; Carcinogenesis; Cell proliferation; Hepatocellular carcinoma
DO  - http://dx.doi.org/10.1016/j.mrfmmm.2006.12.006
ER  - 



TY  - JOUR
T1  - Microarray assay for evaluation of the genetic stability of modified vaccinia virus Ankara B5R gene
AN  - 19527221; 8029528
AB  - Adverse events associated with the use of live smallpox vaccines have led to the development of a new generation of attenuated smallpox vaccines that are prepared in cultured cells as alternatives. The inability to conduct direct clinical evaluation of their efficacy in humans demands that licensure be based on animal studies and exhaustive evaluation of their in vitro properties. One of the most important characteristics of live viral vaccines is their genetic stability, including reversion of the vaccine strain to more virulent forms, recombination with other viral sequences to produce potentially pathogenic viruses, and genetic drift that can result in decrease of immunogenicity and efficacy. To study genetic stability of an immunoessential vaccinia virus gene in a new generation smallpox vaccine, an advanced oligonucleotide microchip was developed and used to assay for mutations that could emerge in B5R gene, a vaccinia virus gene encoding for a protein that contains very important neutralizing epitopes. This microarray contained overlapping oligonucleotides covering the B5R gene of modified vaccinia virus Ankara (MVA), a well-studied candidate smallpox vaccine. The microarray assay was shown to be able to detect even a single point mutation, and to differentiate between vaccinia strains. At the same time, it could detect newly emerged mutations in clones of vaccinia strains. In the work described here, it was shown that MVA B5R gene was stable after 34 passages in Vero and MRC-5 cells that were proposed for use as cell substrates for vaccine manufacture. Potentially, the proposed method could be used as an identity test and could be extended for the entire viral genome and used to monitor consistency of vaccine production. J. Med. Virol. 79: 791-802, 2007.
JF  - Journal of Medical Virology
AU  - Laassri, Majid
AU  - Meseda, Clement A
AU  - Williams, Ollie
AU  - Merchlinsky, Michael
AU  - Weir, Jerry P
AU  - Chumakov, Konstantin
AD  - Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM 470, Rockville, Maryland 20852, majid.laassri@fda.hhs.gov
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 791
EP  - 802
PB  - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/]
VL  - 79
IS  - 6
SN  - 0146-6615, 0146-6615
KW  - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts
KW  - Genomes
KW  - Vaccinia
KW  - Point mutation
KW  - Reversion
KW  - Oligonucleotides
KW  - Smallpox
KW  - Recombination
KW  - Vaccinia virus
KW  - Immunogenicity
KW  - microchips
KW  - Vaccines
KW  - Genetic drift
KW  - Epitopes
KW  - V 22300:Methods
KW  - W 30915:Pharmaceuticals & Vaccines
KW  - G 07780:Fungi
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L2  - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Virology&rft.atitle=Microarray+assay+for+evaluation+of+the+genetic+stability+of+modified+vaccinia+virus+Ankara+B5R+gene&rft.au=Laassri%2C+Majid%3BMeseda%2C+Clement+A%3BWilliams%2C+Ollie%3BMerchlinsky%2C+Michael%3BWeir%2C+Jerry+P%3BChumakov%2C+Konstantin&rft.aulast=Laassri&rft.aufirst=Majid&rft.date=2007-06-01&rft.volume=79&rft.issue=6&rft.spage=791&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Virology&rft.issn=01466615&rft_id=info:doi/10.1002%2Fjmv.20889
LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Genomes; Smallpox; Recombination; Immunogenicity; Vaccinia; Point mutation; microchips; Reversion; Vaccines; Genetic drift; Oligonucleotides; Epitopes; Vaccinia virus
DO  - http://dx.doi.org/10.1002/jmv.20889
ER  - 



TY  - JOUR
T1  - Common variants in genes that mediate immunity and risk of multiple myeloma
AN  - 19521735; 8079427
AB  - Multiple myeloma (MM) is a B-cell malignancy characterized by aberrant immune function. Using genomic DNA extracted from 127 MM cases aged 21-84 years and 545 population-based controls, we examined the risk of MM associated with 82 common variants in 45 genes that mediate immunity among women of European American descent. Genotyping was determined using validated and optimized TaqMan assays. We estimated haplotype frequencies from unphased genotype data for 20 of these genes using the expectation-maximization progressive insertion algorithm. Compared with controls, MM risk was positively associated with homozygotes of single loci, IL4R (-28120T, rs2107356) and FCGR2A (-120G, rs1801274) (OR = 1.91, 95% CI 1.08-3.38 and 1.95, 95% CI 1.06-3.60, respectively). For genes in which linkage disequilibrium was observed between multiple loci, MM risk was positively associated with the haplotype block covering part of the LTA*TNF complex (LTA -82C/-90G *TNF -1036C/-487G/-417G, OR = 1.63, 95% CI 1.02-2.16) compared with the most frequently occurring haplotype observed among controls (LTA -82A/-90A *TNF -1036C/-487G/-417G). Our findings provide preliminary evidence that common genetic variants in specific immune-mediated pathways could influence the risk of MM.
JF  - International Journal of Cancer
AU  - Brown, Elizabeth E
AU  - Lan, Qing
AU  - Zheng, Tongzhang
AU  - Zhang, Yawei
AU  - Wang, Sophia S
AU  - Hoar-Zahm, Shelia
AU  - Chanock, Stephen J
AU  - Rothman, Nathaniel
AU  - Baris, Dalsu
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, elbrown@uab.edu
Y1  - 2007/06//
PY  - 2007
DA  - Jun 2007
SP  - 2715
EP  - 2722
PB  - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/]
VL  - 120
IS  - 12
SN  - 0020-7136, 0020-7136
KW  - Genetics Abstracts; Risk Abstracts; Immunology Abstracts
KW  - Data processing
KW  - double prime Fc receptors
KW  - multiple myeloma
KW  - Lymphocytes B
KW  - Genotyping
KW  - Tumor necrosis factor
KW  - Algorithms
KW  - haplotypes
KW  - Immunity
KW  - Genotypes
KW  - Interleukin 4 receptors
KW  - Cancer
KW  - Homozygotes
KW  - Linkage disequilibrium
KW  - Malignancy
KW  - Multiple myeloma
KW  - Haplotypes
KW  - Insertion
KW  - DNA
KW  - Immune response
KW  - genomics
KW  - G 07720:Immunogenetics
KW  - F 06915:Cancer Immunology
KW  - R2 23060:Medical and environmental health
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LA  - English
DB  - ProQuest Environmental Science Collection
N1  - Date revised - 2008-04-01
N1  - Last updated - 2015-03-27
N1  - SubjectsTermNotLitGenreText - Data processing; double prime Fc receptors; Lymphocytes B; Tumor necrosis factor; Genotyping; Algorithms; Genotypes; Immunity; Interleukin 4 receptors; Homozygotes; Linkage disequilibrium; Malignancy; Haplotypes; Multiple myeloma; Insertion; genomics; Immune response; multiple myeloma; DNA; haplotypes; Cancer
DO  - http://dx.doi.org/10.1002/ijc.22618
ER  -