TY - JOUR T1 - The U.S. Mandatory Guidelines for Federal Workplace Drug Testing Programs: current status and future considerations. AN - 70194762; 17434274 AB - The U.S. Department of Health and Human Services (HHS) drug testing standards were published in 1988 and revised in 1994, 1998, and 2004. In 2004, significant revisions defining, standardizing, and requiring specimen validity testing on Federal employee donor urine specimens were included. In a separate notice, HHS proposed to establish scientific and technical guidelines for the Federal Workplace Drug Testing Program to: (1) permit laboratory testing of hair, oral fluid, and sweat patch specimens in addition to urine specimens for marijuana, cocaine, phencyclidine, opiates (with focus on heroin), and amphetamines [including methylenedioxymethamphetamine (MDMA), methylenedioxyethamphetamine (MDEA), methylenedioxyamphetamine (MDA)]; (2) permit use of on-site point of collection test (POCT) devices to test urine and oral fluid at collection sites; (3) permit use of instrumented initial test (screening only) facilities [IITF] to quickly identify negative specimens; and (4) add training requirement for collectors, on-site testers, and MROs. This proposal was published in the Federal Register on 13 April 2004, with a 90-day public comment period. The Substance Abuse and Mental Health Services Administration, HHS, reviewed those comments and is preparing the Final Notice that will define the requirements for such testing, including: specimen collection procedures, custody and control procedures that ensure donor specimen identity and integrity, testing facility, initial and confirmatory test cutoff concentrations, analytical testing methods, result review and reporting, evaluation of alternative medical explanations for presence of drug or metabolite in the donor's specimen, and laboratory certification issues. Voluntary pilot performance testing (PT) programs for each specimen type are on-going since April 2000 to determine how to prepare PT materials for specimens other than urine to evaluate laboratories' ability to routinely achieve accuracy and precision required. Certification programs will be developed using the current urine drug testing National Laboratory Certification Program model. The addition of accurate and reliable workplace drug testing using hair, oral fluid, and sweat patch specimens will complement urine drug testing, and aid in combating industries devoted to suborning drug testing through adulteration, substitution, and dilution. For example, hair testing may detect chronic drug use for up to 90 days and be useful in pre-employment situations; oral fluid testing may detect drug use in past hours and be useful in post-accident situations; sweat patch testing may be useful in follow-up drug testing and treatment programs; POCTs and IITFs may be most useful for quickly identifying specimens that are negative for drugs and indicate that the specimen is valid. JF - Forensic science international AU - Bush, Donna M AD - Division of Workplace Programs, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, One Choke Cherry Road, Room 2-1033, Rockville, MD 20857, USA. Donna.Bush@samhsa.hhs.gov Y1 - 2008/01/30/ PY - 2008 DA - 2008 Jan 30 SP - 111 EP - 119 VL - 174 IS - 2-3 KW - Index Medicus KW - United States KW - Substance-Related Disorders -- diagnosis KW - Sweat -- chemistry KW - Saliva -- chemistry KW - Organizational Policy KW - Humans KW - Hair -- chemistry KW - United States Dept. of Health and Human Services KW - Occupational Health Services KW - Workplace KW - Mandatory Programs KW - Substance Abuse Detection -- legislation & jurisprudence KW - Substance Abuse Detection -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70194762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Forensic+science+international&rft.atitle=The+U.S.+Mandatory+Guidelines+for+Federal+Workplace+Drug+Testing+Programs%3A+current+status+and+future+considerations.&rft.au=Bush%2C+Donna+M&rft.aulast=Bush&rft.aufirst=Donna&rft.date=2008-01-30&rft.volume=174&rft.issue=2-3&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Forensic+science+international&rft.issn=1872-6283&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Evaluation of Modern Extraction Methods for the Analysis of Analytes Related to Food Defence T2 - 10th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers and 10th International Symposium on Advances in Extraction Techniques (HTC - ExTech 10) AN - 40686062; 4746495 JF - 10th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers and 10th International Symposium on Advances in Extraction Techniques (HTC - ExTech 10) AU - De Jager, L.S. AU - Perfetti, G A AU - Begley, T H AU - Diachenko, G W Y1 - 2008/01/28/ PY - 2008 DA - 2008 Jan 28 KW - Food KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40686062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Symposium+on+Hyphenated+Techniques+in+Chromatography+and+Hyphenated+Chromatographic+Analyzers+and+10th+International+Symposium+on+Advances+in+Extraction+Techniques+%28HTC+-+ExTech+10%29&rft.atitle=Evaluation+of+Modern+Extraction+Methods+for+the+Analysis+of+Analytes+Related+to+Food+Defence&rft.au=De+Jager%2C+L.S.%3BPerfetti%2C+G+A%3BBegley%2C+T+H%3BDiachenko%2C+G+W&rft.aulast=De+Jager&rft.aufirst=L.S.&rft.date=2008-01-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Symposium+on+Hyphenated+Techniques+in+Chromatography+and+Hyphenated+Chromatographic+Analyzers+and+10th+International+Symposium+on+Advances+in+Extraction+Techniques+%28HTC+-+ExTech+10%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ordibo.be/htc/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Survey results of benzene in soft drinks and other beverages by headspace gas chromatography/mass spectrometry. AN - 70209758; 18072742 AB - Benzene, a carcinogen that can cause cancer in humans, may form at nanogram per gram levels in some beverages containing both benzoate salts and ascorbic or erythorbic acids. Through a series of reactions, a hydroxyl radical forms that can decarboxylate benzoate to form benzene. Elevated temperatures and light stimulate these reactions, while sugar and ethylenediaminetetraacetic acid (EDTA) can inhibit them. A headspace gas chromatography/mass spectrometry method for the determination of benzene in beverages was developed and validated. The method was used to conduct a survey of 199 soft drinks and other beverages. The vast majority of beverages sampled contained either no detectable benzene or levels below the U.S. Environmental Protection Agency's drinking water limit of 5 ng/g. Beverages found to contain 5 ng/g benzene or more were reformulated by the manufacturers. The amount of benzene found in the reformulated beverages ranged from none detected to 1.1 ng/g. JF - Journal of agricultural and food chemistry AU - Nyman, Patricia J AU - Diachenko, Gregory W AU - Perfetti, Gracia A AU - McNeal, Timothy P AU - Hiatt, Michael H AU - Morehouse, Kim M AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-706, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Patricia.Nyman@fda.hhs.gov Y1 - 2008/01/23/ PY - 2008 DA - 2008 Jan 23 SP - 571 EP - 576 VL - 56 IS - 2 SN - 0021-8561, 0021-8561 KW - Carcinogens KW - 0 KW - Benzene KW - J64922108F KW - Index Medicus KW - Reproducibility of Results KW - Maximum Allowable Concentration KW - Carcinogens -- analysis KW - Carbonated Beverages -- analysis KW - Benzene -- analysis KW - Beverages -- analysis KW - Gas Chromatography-Mass Spectrometry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70209758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Survey+results+of+benzene+in+soft+drinks+and+other+beverages+by+headspace+gas+chromatography%2Fmass+spectrometry.&rft.au=Nyman%2C+Patricia+J%3BDiachenko%2C+Gregory+W%3BPerfetti%2C+Gracia+A%3BMcNeal%2C+Timothy+P%3BHiatt%2C+Michael+H%3BMorehouse%2C+Kim+M&rft.aulast=Nyman&rft.aufirst=Patricia&rft.date=2008-01-23&rft.volume=56&rft.issue=2&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Comparison of Cold-adapted and DNA Prime-Adenovirus Boost Vaccines for Induction of Heterosubtypic Immunity to Influenza A Virus T2 - 2008 Keystone Symposia on Viral Immunity (A5) AN - 40721949; 4762565 JF - 2008 Keystone Symposia on Viral Immunity (A5) AU - Epstein, Suzanne L Y1 - 2008/01/20/ PY - 2008 DA - 2008 Jan 20 KW - Vaccines KW - Influenza KW - DNA vaccines KW - Immunity KW - Disease control KW - Influenza A virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40721949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.atitle=Comparison+of+Cold-adapted+and+DNA+Prime-Adenovirus+Boost+Vaccines+for+Induction+of+Heterosubtypic+Immunity+to+Influenza+A+Virus&rft.au=Epstein%2C+Suzanne+L&rft.aulast=Epstein&rft.aufirst=Suzanne&rft.date=2008-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 4&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Inactivated influenza vaccine (IIV) in children <2 years of age: examination of selected adverse events reported to the Vaccine Adverse Event Reporting System (VAERS) after thimerosal-free or thimerosal-containing vaccine. AN - 70190886; 18093701 AB - Thimerosal as a preservative (in all but trace amounts) was removed from vaccines used in infants starting in the late 1990s, though the preservative-including inactivated influenza vaccine is still available for use in individuals >or=6 months of age. We compared the proportion of injection site reactions, rash, and infections reported to the Vaccine Adverse Event Reporting System (VAERS) after preservative-free (PFV), preservative-including (PIV), and preservative unknown (PUV) vaccines in reports from 7/1/2004 to 1/4/2006. There were 145, 175, and 216 reports after vaccination with PFV, PIV, and PUV, respectively. The most frequently reported coding terms (fever, rash, and urticaria) were seen in similar proportions in the PFV, PIV, and PUV groups. No difference was detected in the proportion of injection site reactions (ISR), rash, or infections in the PIV, PFV, and PUV reports. Keeping in mind the inherent limitations of VAERS, including underreporting and potential reporting biases, we conclude that there were no substantial differences in the proportion of rash, ISR, and infection reports in the PIV, PFV and PUV reports in infants. JF - Vaccine AU - McMahon, A W AU - Iskander, J K AU - Haber, P AU - Braun, M M AU - Ball, R AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, USA. ann.mcmahon@fda.hhs.gov Y1 - 2008/01/17/ PY - 2008 DA - 2008 Jan 17 SP - 427 EP - 429 VL - 26 IS - 3 SN - 0264-410X, 0264-410X KW - Influenza Vaccines KW - 0 KW - Preservatives, Pharmaceutical KW - Vaccines, Inactivated KW - Thimerosal KW - 2225PI3MOV KW - Index Medicus KW - Infant KW - Fever -- etiology KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Infant, Newborn KW - Databases, Factual KW - Urticaria -- etiology KW - Exanthema -- etiology KW - Vaccination KW - Child, Preschool KW - Thimerosal -- adverse effects KW - Thimerosal -- administration & dosage KW - Vaccines, Inactivated -- administration & dosage KW - Vaccines, Inactivated -- adverse effects KW - Influenza Vaccines -- adverse effects KW - Preservatives, Pharmaceutical -- adverse effects KW - Preservatives, Pharmaceutical -- administration & dosage KW - Influenza Vaccines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70190886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Inactivated+influenza+vaccine+%28IIV%29+in+children+%26lt%3B2+years+of+age%3A+examination+of+selected+adverse+events+reported+to+the+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29+after+thimerosal-free+or+thimerosal-containing+vaccine.&rft.au=McMahon%2C+A+W%3BIskander%2C+J+K%3BHaber%2C+P%3BBraun%2C+M+M%3BBall%2C+R&rft.aulast=McMahon&rft.aufirst=A&rft.date=2008-01-17&rft.volume=26&rft.issue=3&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-31 N1 - Date created - 2008-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate. AN - 70248296; 18223208 AB - On June 28, 2006, the U.S. Food and Drug Administration approved dasatinib (Sprycel; Bristol-Myers Squibb), a new small-molecule inhibitor of multiple tyrosine kinases, for the treatment of adults with chronic phase, accelerated phase, or myeloid or lymphoid blast phase chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) with resistance or intolerance to prior therapy including imatinib. This summary reviews the database supporting this approval. Four single-arm multicenter studies supported the efficacy and safety of dasatinib. The primary efficacy end point in chronic phase CML was major cytogenetic response. The primary end point in accelerated phase, myeloid phase, and lymphoid blast phase CML, and Ph(+) ALL was major hematologic response. The four studies combined enrolled 445 patients. In patients with chronic phase CML, the major cytogenetic response rate was 45% with a complete cytogenetic response rate of 33%. Major hematologic response rates in patients with accelerated phase CML, myeloid CML, lymphoid blast CML, and Ph(+) ALL were 59%, 32%, 31%, and 42%, respectively. Median response durations in chronic phase, accelerated phase, and myeloid phase CML had not been reached. The median durations of major hematologic response were 3.7 months in lymphoid blast CML and 4.8 months in Ph(+) ALL. Common toxicities with dasatinib included myelosuppression, bleeding, and fluid retention. This report describes the Food and Drug Administration review supporting the approval of dasatinib for CML and Ph(+) ALL based on the rates and durability of cytogenetic and hematologic responses. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Brave, Michael AU - Goodman, Vicki AU - Kaminskas, Edvardas AU - Farrell, Ann AU - Timmer, William AU - Pope, Sarah AU - Harapanhalli, Ravi AU - Saber, Haleh AU - Morse, David AU - Bullock, Julie AU - Men, Angela AU - Noory, Carol AU - Ramchandani, Roshni AU - Kenna, Leslie AU - Booth, Brian AU - Gobburu, Joga AU - Jiang, Xiaoping AU - Sridhara, Rajeshwari AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Office of New Drugs, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA. michael.brave@fda.hhs.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 352 EP - 359 VL - 14 IS - 2 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Benzamides KW - Piperazines KW - Protein Kinase Inhibitors KW - Pyrimidines KW - Thiazoles KW - Imatinib Mesylate KW - 8A1O1M485B KW - Dasatinib KW - RBZ1571X5H KW - Index Medicus KW - United States KW - Multicenter Studies as Topic KW - Clinical Trials, Phase II as Topic KW - Protein Kinase Inhibitors -- pharmacology KW - Humans KW - Drug Resistance, Neoplasm KW - United States Food and Drug Administration KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- adverse effects KW - Clinical Trials, Phase I as Topic KW - Drug Approval KW - Protein Kinase Inhibitors -- chemistry KW - Pyrimidines -- chemistry KW - Thiazoles -- chemistry KW - Pyrimidines -- adverse effects KW - Pyrimidines -- therapeutic use KW - Piperazines -- therapeutic use KW - Pyrimidines -- pharmacology KW - Thiazoles -- adverse effects KW - Leukemia, Myeloid, Chronic-Phase -- drug therapy KW - Antineoplastic Agents -- adverse effects KW - Thiazoles -- pharmacology KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Thiazoles -- therapeutic use KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70248296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Sprycel+for+chronic+myeloid+leukemia+and+Philadelphia+chromosome-positive+acute+lymphoblastic+leukemia+resistant+to+or+intolerant+of+imatinib+mesylate.&rft.au=Brave%2C+Michael%3BGoodman%2C+Vicki%3BKaminskas%2C+Edvardas%3BFarrell%2C+Ann%3BTimmer%2C+William%3BPope%2C+Sarah%3BHarapanhalli%2C+Ravi%3BSaber%2C+Haleh%3BMorse%2C+David%3BBullock%2C+Julie%3BMen%2C+Angela%3BNoory%2C+Carol%3BRamchandani%2C+Roshni%3BKenna%2C+Leslie%3BBooth%2C+Brian%3BGobburu%2C+Joga%3BJiang%2C+Xiaoping%3BSridhara%2C+Rajeshwari%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Brave&rft.aufirst=Michael&rft.date=2008-01-15&rft.volume=14&rft.issue=2&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-4175 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-4175 ER - TY - JOUR T1 - Risk of testicular germ-cell tumours in relation to childhood physical activity AN - 20620530; 8074890 AB - The US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case-control study of testicular germ-cell tumours (TGCTs) enrolled participants and their mothers in 2002-2005. Hours of sports or vigorous childhood physical activity per week were ascertained for three time periods; 1st-5th grades, 6th-8th grades and 9th-12th grades. Son- and mother-reports were analysed separately and included 539 control son-mother pairs and 499 case son-mother pairs. Odds ratios and 95% confidence intervals were produced. The analysis of the sons' responses found no relationship between childhood physical activity and TGCT, while the mothers' analysis found an inverse association, which was solely due to nonseminoma. Future studies should seek to validate responses further using recorded information sources such as school records. JF - British Journal of Cancer AU - Cook, M B AU - Zhang, Y AU - Graubard, B I AU - Rubertone, M V AU - Erickson, R L AU - McGlynn, KA AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS/5005, 6120 Executive Boulevard, Rockville, MD 20892-7234, USA, cookmich@mail.nih.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 174 EP - 178 VL - 98 IS - 1 SN - 0007-0920, 0007-0920 KW - Physical Education Index; Risk Abstracts KW - Tumors KW - Exercise KW - Children KW - Sports KW - Cancer KW - Grading KW - Schools KW - Analysis KW - physical activity KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20620530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Risk+of+testicular+germ-cell+tumours+in+relation+to+childhood+physical+activity&rft.au=Cook%2C+M+B%3BZhang%2C+Y%3BGraubard%2C+B+I%3BRubertone%2C+M+V%3BErickson%2C+R+L%3BMcGlynn%2C+KA&rft.aulast=Cook&rft.aufirst=M&rft.date=2008-01-15&rft.volume=98&rft.issue=1&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604109 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Grading; Exercise; Analysis; Tumors; Sports; Schools; Cancer; physical activity; Children DO - http://dx.doi.org/10.1038/sj.bjc.6604109 ER - TY - JOUR T1 - Toll-free number for reporting adverse events on labeling for human drug products. Interim final rule. AN - 70478173; 18389912 AB - The Food and Drug Administration (FDA) is issuing an interim final rule to codify the provisions of the proposed rule entitled "Toll-Free Number for Reporting Adverse Events on Labeling for Human Drug Products" (69 FR 21778, April 22, 2004) (the toll-free number proposed rule or proposed rule) that, under the Food and Drug Administration Amendments Act of 2007 (FDAAA), became effective by operation of law on January 1, 2008. This interim final rule requires the addition of a statement on the labeling of certain human drug products for which an application is approved under the Federal Food, Drug, and Cosmetic Act (the act). The added statement includes a toll-free number and advises that the number is to be used only for reporting side effects and is not intended for medical advice (the side effects statement). As mandated by FDAAA, this interim final rule does not apply to over-the-counter drug products approved as new drugs under the act if the product packaging includes a manufacturer's or distributor's toll-free number for reporting complaints. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2008/01/03/ PY - 2008 DA - 2008 Jan 03 SP - 402 EP - 404 VL - 73 IS - 2 SN - 0097-6326, 0097-6326 KW - Health technology assessment KW - United States KW - Humans KW - Adverse Drug Reaction Reporting Systems -- legislation & jurisprudence KW - Drug Labeling -- legislation & jurisprudence KW - Hotlines -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70478173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Toll-free+number+for+reporting+adverse+events+on+labeling+for+human+drug+products.+Interim+final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2008-01-03&rft.volume=73&rft.issue=2&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-25 N1 - Date created - 2008-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD AN - 19468490; 7936212 AB - The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) and its amyloidogenic beta -amyloid (A beta ) product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ( beta -site APP cleaving enzyme 1)] as well as their transcriptional regulator (Sp1) were elevated in aged (23-year-old) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of A beta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. JF - Journal of Neuroscience AU - Wu, Jinfang AU - Basha, MdRiyaz AU - Brock, Brian AU - Cox, David P AU - Cardozo-Pelaez, Fernando AU - McPherson, Christopher A AU - Harry, Jean AU - Rice, Deborah C AU - Maloney, Bryan AU - Chen, Demao AU - Lahiri, Debomoy K AU - Zawia, Nasser H AD - Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana 59812, National Institutes of Health, Research Triangle Park, North Carolina 27709, Maine Department of Health and Human Services, Augusta, Maine 04333, and Laboratory for Molecular Neurogenetics, Institute for Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 Y1 - 2008/01/02/ PY - 2008 DA - 2008 Jan 02 SP - 3 EP - 9 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 28 IS - 1 SN - 0270-6474, 0270-6474 KW - Genetics Abstracts; Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Data processing KW - Chromium KW - Heavy metals KW - Alzheimer's disease KW - Brain KW - Cortex (frontal) KW - Transcription KW - Imprinting KW - Lead KW - Amyloidogenesis KW - Amyloid precursor protein KW - DNA damage KW - Neurodegenerative diseases KW - Sp1 protein KW - Cortex KW - beta -Site APP cleaving enzyme 1 KW - epigenetics KW - Geriatrics KW - DNA methyltransferase KW - Plaques KW - beta -Amyloid KW - Secretase KW - Infants KW - N 14820:DNA Metabolism & Structure KW - N3 11028:Neuropharmacology & toxicology KW - X 24360:Metals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19468490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Alzheimer%27s+Disease+%28AD%29-Like+Pathology+in+Aged+Monkeys+after+Infantile+Exposure+to+Environmental+Metal+Lead+%28Pb%29%3A+Evidence+for+a+Developmental+Origin+and+Environmental+Link+for+AD&rft.au=Wu%2C+Jinfang%3BBasha%2C+MdRiyaz%3BBrock%2C+Brian%3BCox%2C+David+P%3BCardozo-Pelaez%2C+Fernando%3BMcPherson%2C+Christopher+A%3BHarry%2C+Jean%3BRice%2C+Deborah+C%3BMaloney%2C+Bryan%3BChen%2C+Demao%3BLahiri%2C+Debomoy+K%3BZawia%2C+Nasser+H&rft.aulast=Wu&rft.aufirst=Jinfang&rft.date=2008-01-02&rft.volume=28&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Chromium; Heavy metals; Alzheimer's disease; Brain; Transcription; Cortex (frontal); Imprinting; Amyloidogenesis; Lead; Amyloid precursor protein; Sp1 protein; Neurodegenerative diseases; DNA damage; Cortex; beta -Site APP cleaving enzyme 1; epigenetics; Geriatrics; DNA methyltransferase; Plaques; Secretase; beta -Amyloid; Infants ER - TY - JOUR T1 - Development of a taxonomy for indexing Web-based mining safety and health research AN - 753846500; 2010-075077 JF - Publication Series - Australasian Institute of Mining and Metallurgy AU - Glowacki, A F A2 - Saydam, Serkan Y1 - 2008 PY - 2008 DA - 2008 SP - 125 EP - 129 PB - AusIMM - Australasian Institute of Mining and Metallurgy, Carlton, Victoria VL - 10/2008 SN - 1324-6240, 1324-6240 KW - occupational safety KW - mining legislation KW - mining KW - safety KW - regulations KW - data processing KW - taxonomy KW - computer networks KW - research KW - information management KW - Internet KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753846500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Publication+Series+-+Australasian+Institute+of+Mining+and+Metallurgy&rft.atitle=Development+of+a+taxonomy+for+indexing+Web-based+mining+safety+and+health+research&rft.au=Glowacki%2C+A+F&rft.aulast=Glowacki&rft.aufirst=A&rft.date=2008-01-01&rft.volume=10%2F2008&rft.issue=&rft.spage=125&rft.isbn=9781920806927&rft.btitle=&rft.title=Publication+Series+-+Australasian+Institute+of+Mining+and+Metallurgy&rft.issn=13246240&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Future mining 2008, first international Future mining conference and exhibition 2008 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Produced under license from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia N1 - Date revised - 2010-01-01 N1 - Number of references - 27 N1 - PubXState - Victoria N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - computer networks; data processing; information management; Internet; mining; mining legislation; occupational safety; regulations; research; safety; taxonomy ER - TY - JOUR T1 - Possible impact of new safety technology developments on the future of the United States mining industry AN - 753845073; 2010-075071 JF - Publication Series - Australasian Institute of Mining and Metallurgy AU - Gurtunca, R G A2 - Saydam, Serkan Y1 - 2008 PY - 2008 DA - 2008 SP - 3 EP - 9 PB - AusIMM - Australasian Institute of Mining and Metallurgy, Carlton, Victoria VL - 10/2008 SN - 1324-6240, 1324-6240 KW - United States KW - occupational safety KW - mining legislation KW - mining KW - mines KW - explosions KW - natural gas KW - safety management systems KW - legislation KW - coal mines KW - petroleum KW - preventive measures KW - new methods KW - communication systems KW - ventilation KW - safety KW - future KW - coalbed methane KW - industry KW - coal deposits KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753845073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Publication+Series+-+Australasian+Institute+of+Mining+and+Metallurgy&rft.atitle=Possible+impact+of+new+safety+technology+developments+on+the+future+of+the+United+States+mining+industry&rft.au=Gurtunca%2C+R+G&rft.aulast=Gurtunca&rft.aufirst=R&rft.date=2008-01-01&rft.volume=10%2F2008&rft.issue=&rft.spage=3&rft.isbn=9781920806927&rft.btitle=&rft.title=Publication+Series+-+Australasian+Institute+of+Mining+and+Metallurgy&rft.issn=13246240&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Future mining 2008, first international Future mining conference and exhibition 2008 N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Produced under license from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia N1 - Date revised - 2010-01-01 N1 - Number of references - 8 N1 - PubXState - Victoria N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - coal deposits; coal mines; coalbed methane; communication systems; explosions; future; industry; legislation; mines; mining; mining legislation; natural gas; new methods; occupational safety; petroleum; preventive measures; safety; safety management systems; United States; ventilation ER - TY - JOUR T1 - Respiratory Disease in Agricultural Workers: Mortality and Morbidity Statistics AN - 746162964; 13054597 AB - To quantify the respiratory disease burden among agricultural workers, we examined the 1988-1998 National Center for Health Statistics (NCHS) "Multiple Cause of Death Data" and the 1988-1994 Third National Health and Nutrition Examination Survey data (NHANES III). Proportionate mortality ratios (PMRs) were determined for 11 respiratory conditions among 6 agricultural groups: crop farm workers, livestock farm workers, farm managers, landscape and horticultural workers, forestry workers, and fishery workers. Prevalence ratios (PRs) were determined for 12 respiratory conditions among 3 agricultural groups: farm workers, farm managers, and other agricultural workers. Disease categories groups were based on the 9th International Classification of Diseases and the agricultural groups on the NCHS or NHANES III industry and occupation codes, respectively. Crop farm workers and livestock farm workers had significantly elevated mortality for several respiratory conditions, with mortality for hypersensitivity pneumonitis being 10 and 50 times higher than expected. Landscape and horticultural workers had significantly elevated mortality for abscess of the lung and mediastinum and chronic airways obstruction. Forestry workers had significantly elevated mortality for pulmonary tuberculosis, chronic airways obstruction, and pneumonia. Prevalence of wheeze was elevated for female farm workers, shortness of breath was elevated for farm workers who had ever smoked, and hay fever was elevated for black, non-Hispanic farm workers. Prevalence of asthma was elevated for other agricultural workers who had ever smoked. Farm workers had a PR of 173 for obstructive respiratory abnormality. Continued improvement in occupational health surveillance systems for agriculture is essential to help guide prevention efforts for respiratory disease. JF - Journal of Agromedicine AU - Greskevitch, M AU - Kullman, G AU - Bang, K M AU - Mazurek, J M AD - Division of Respiratory Disease Studies (DRDS), National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC) Y1 - 2008 PY - 2008 DA - 2008 SP - 5 EP - 10 VL - 12 IS - 3 SN - 1059-924X, 1059-924X KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Agriculture KW - Statistics KW - Farms KW - Mycobacterium KW - Respiratory diseases KW - Nutrition KW - Crops KW - Morbidity KW - Workers KW - Classification KW - hay fever KW - farms KW - Fisheries KW - prevention KW - Tuberculosis KW - Forestry KW - Respiratory tract KW - Mortality KW - Data processing KW - Landscape KW - agriculture KW - Asthma KW - Abscesses KW - Mediastinum KW - Livestock KW - tuberculosis KW - hypersensitivity KW - Lung KW - classification KW - Hay fever KW - Pneumonia KW - Alveolitis KW - Occupational health KW - J 02320:Cell Biology KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746162964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=Respiratory+Disease+in+Agricultural+Workers%3A+Mortality+and+Morbidity+Statistics&rft.au=Greskevitch%2C+M%3BKullman%2C+G%3BBang%2C+K+M%3BMazurek%2C+J+M&rft.aulast=Greskevitch&rft.aufirst=M&rft.date=2008-01-01&rft.volume=12&rft.issue=3&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F10599240701881482 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Agriculture; Mortality; Farms; Statistics; Data processing; Landscape; Asthma; Abscesses; Mediastinum; Nutrition; Morbidity; Crops; Livestock; Workers; Classification; Lung; Fisheries; Tuberculosis; Hay fever; Alveolitis; Pneumonia; Respiratory tract; Forestry; agriculture; Respiratory diseases; tuberculosis; hypersensitivity; hay fever; farms; classification; prevention; Occupational health; Mycobacterium DO - http://dx.doi.org/10.1080/10599240701881482 ER - TY - JOUR T1 - Respirator Use and Practices in Agricultural Crop Production Establishments AN - 746161866; 13054599 AB - The risk of developing respiratory diseases can be reduced by either wearing respiratory protection under the guidance of an effective respiratory protection program or using controls. In 2001, the Survey of Respirator Use and Practices gathered information on the types of respirators used, respirator use practices, and the respirator program characteristics from 40,002 randomly selected US establishments. This report presents findings of the Survey of Respirator Use and Practices for the Agricultural Production--Crops industry and compares them with National Institute for Occupational Safety and Health (NIOSH) recommendations. Approximately one third of all Agricultural Production--Crops establishments required respirator use. Of the Agricultural Production--Crops establishments that required respirator use, (1) a written program to determine what type of respirator to use was not adopted by management in 73% of the establishments; (2) 21% did not know whether air sampling was conducted for substances for which employees were required to use respirators; (3) 29.5% did not provide respirator training for employees; (4) employees were not assessed for medical fitness to wear a respirator or it was not known whether the employees were assessed, in 49.4%; and (5) the program administrator had received no respirator training in 29.5%. Of the Agricultural Production--Crops establishments that required respirator use, 69.5% had at least 3 indicators of a potentially inadequate respiratory protection program. The high rates of indicators of potential inadequacies suggest widespread problems with respiratory protection programs in the Agricultural Production--Crops industry, indicating a potential for improvement. JF - Journal of Agromedicine AU - Greskevitch, M AU - Doney, B AU - Groce, D AU - Syamlal, G AU - Bang, K M AD - National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 25 EP - 31 VL - 12 IS - 3 SN - 1059-924X, 1059-924X KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746161866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=Respirator+Use+and+Practices+in+Agricultural+Crop+Production+Establishments&rft.au=Greskevitch%2C+M%3BDoney%2C+B%3BGroce%2C+D%3BSyamlal%2C+G%3BBang%2C+K+M&rft.aulast=Greskevitch&rft.aufirst=M&rft.date=2008-01-01&rft.volume=12&rft.issue=3&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F10599240801887801 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/10599240801887801 ER - TY - JOUR T1 - Adverse effects of fullerenes on endothelial cells: fullerenol C60(OH)24 induced tissue factor and ICAM-I membrane expression and apoptosis in vitro. AN - 70755088; 18488416 AB - We studied the effects of a C60 water suspension at 4 microg/mL (nC60) and the water soluble fullerenol C60(OH)24 at final concentrations of 1-100 microg/mL on human umbilical vein endothelial cells (HUVECs) in culture. We found that a 24 hr treatment of HUVECs with C60(OH)24 at 100 microg/mL significantly increased cell surface expression of ICAM-1(CD54) (67 +/- 4% CD54+ cells vs. 19 +/- 2 % CD540 cells in control; p < 0.001). In addition, this treatment induced the expression of tissue factor (CD142) on HUVECs (54 +/- 20% CD142+ cells vs 4 +/- 2% CD142+ cells in control; p = 0.008) and increased exposure of phosphatidylserine (PS) (29 +/- 2% PS+ cells vs. 12 +/- 5% PS+ cells in control; p < 0.001). Analysis of cell cycle and DNA fragmentation (TUNEL) showed that both nC60 and C60(OH)24 caused G1 arrest of HUVECs and C60(OH)24 induced significant apoptosis (21 +/- 2% TUNEL+ cells at 100 microg/mL of C60(OH)24 vs. 4 +/- 2% TUNEL+ cells in control; p < 0.001). We also demonstrated that both nC60 and C60(OH)24 induced a rapid concentration dependent elevation of intracellular calcium [Ca2+]i. This could be inhibited by EGTA, suggesting that the source of [Ca2+]i in fullerene stimulated calcium flux is predominantly from the extracellular environment. In conclusion, fullerenol C60(OH)24 had both pro-inflammatory and pro-apoptotic effects on HUVECs, indicating possible adverse effects of fullerenes on the endothelium. JF - International journal of nanomedicine AU - Gelderman, Monique P AU - Simakova, Olga AU - Clogston, Jeffrey D AU - Patri, Anil K AU - Siddiqui, Sheena F AU - Vostal, Alexander C AU - Simak, Jan AD - CBER, FDA, 1401 Rockville Pike, HFM 335, Rockville, MD 20852-1448, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 59 EP - 68 VL - 3 IS - 1 SN - 1176-9114, 1176-9114 KW - Fullerenes KW - 0 KW - Intercellular Adhesion Molecule-1 KW - 126547-89-5 KW - fullerenol KW - 182024-42-6 KW - Thromboplastin KW - 9035-58-9 KW - Index Medicus KW - Gene Expression -- drug effects KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Cell Membrane -- drug effects KW - Humans KW - Apoptosis -- drug effects KW - Cell Membrane -- metabolism KW - Endothelial Cells -- drug effects KW - Endothelial Cells -- cytology KW - Thromboplastin -- metabolism KW - Fullerenes -- adverse effects KW - Intercellular Adhesion Molecule-1 -- metabolism KW - Endothelial Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70755088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+nanomedicine&rft.atitle=Adverse+effects+of+fullerenes+on+endothelial+cells%3A+fullerenol+C60%28OH%2924+induced+tissue+factor+and+ICAM-I+membrane+expression+and+apoptosis+in+vitro.&rft.au=Gelderman%2C+Monique+P%3BSimakova%2C+Olga%3BClogston%2C+Jeffrey+D%3BPatri%2C+Anil+K%3BSiddiqui%2C+Sheena+F%3BVostal%2C+Alexander+C%3BSimak%2C+Jan&rft.aulast=Gelderman&rft.aufirst=Monique&rft.date=2008-01-01&rft.volume=3&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=International+journal+of+nanomedicine&rft.issn=11769114&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Mol Life Sci. 2005 May;62(9):971-88 [15761668] Antimicrob Agents Chemother. 1999 Sep;43(9):2273-7 [10471578] Biomaterials. 2005 Dec;26(36):7587-95 [16005959] IEEE Trans Nanobioscience. 2005 Jun;4(2):180-95 [16117026] Curr Opin Chem Biol. 2005 Dec;9(6):674-9 [16233988] Nano Lett. 2005 Dec;5(12):2578-85 [16351219] Circulation. 2006 Feb 7;113(5):722-31 [16461845] Toxicol Sci. 2006 May;91(1):173-83 [16476688] Am J Physiol Cell Physiol. 2006 Jun;290(6):C1495-502 [16407415] Mar Environ Res. 2006 Jul;62 Suppl:S5-9 [16709433] Environ Sci Technol. 2006 Jul 15;40(14):4360-6 [16903271] J Nanosci Nanotechnol. 2006 Jul;6(7):1883-904 [17025102] Biomaterials. 2007 Jan;28(2):344-53 [16934866] Adv Drug Deliv Rev. 2006 Dec 1;58(14):1460-70 [17113677] Clin Cancer Res. 2006 Dec 1;12(23):7086-91 [17145832] J BUON. 2006 Oct-Dec;11(4):391-404 [17309168] Eur J Biochem. 1998 May 15;254(1):38-43 [9652391] J Med Chem. 1999 Nov 4;42(22):4614-20 [10579823] World J Surg. 2000 Apr;24(4):450-4 [10706918] Arch Biochem Biophys. 2000 Jun 15;378(2):216-23 [10860539] J Neurosci Res. 2000 Nov 15;62(4):600-7 [11070504] Transfusion. 2002 Mar;42(3):334-42 [11961239] BMC Cell Biol. 2002 May 28;3:11 [12052248] Eur J Med Chem. 2003 Nov-Dec;38(11-12):913-23 [14642323] Environ Health Perspect. 2004 Jul;112(10):1058-62 [15238277] Philos Trans A Math Phys Eng Sci. 2004 Oct 15;362(1823):2223-38 [15370479] Carcinogenesis. 1996 Oct;17(10):2163-9 [8895484] Antiviral Res. 1997 Mar;34(1):65-70 [9107386] J Pharm Pharmacol. 1997 Apr;49(4):438-45 [9232545] Neurobiol Dis. 1996 Apr;3(2):129-35 [9173920] Tissue Antigens. 1997 Nov;50(5):449-58 [9389318] Jpn J Cancer Res. 1997 Nov;88(11):1108-16 [9439687] Toxicol Pathol. 1998 Jan-Feb;26(1):143-51 [9502397] Br J Pharmacol. 1998 Mar;123(6):1097-102 [9559892] Chem Biol Interact. 1998 Jul 24;114(3):145-59 [9839628] J Neurochem. 1999 Apr;72(4):1634-40 [10098871] FEBS Lett. 1999 Jul 9;454(3):335-40 [10431834] Environ Sci Technol. 2005 Jun 1;39(11):4307-16 [15984814] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clostridium difficile: from obscurity to superbug. AN - 70737461; 18476496 AB - According to the UK media and popular press, Clostridium difficile is now a fully fledged member of that notorious but ill-defined group of microorganisms portrayed to the general public as superbugs. Following the trail blazed by methicillin-resistant Staphylococcus aureus (MRSA), C. difficile has made the transition from being an obscure anaerobic bacterium, mainly of interest to specialist anaerobic microbiologists, to that of an infamous superbug responsible for outbreaks of hospital-acquired infection that commonly result in serious disease and death. This review tracks the rise in scientific knowledge and public awareness of this organism. JF - British journal of biomedical science AU - Brazier, J S AD - Anaerobe Reference Laboratory, National Public Health Service for Wales Microbiology, Cardiff, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, UK. brazier@cardiff.ac.uk Y1 - 2008 PY - 2008 DA - 2008 SP - 39 EP - 44 VL - 65 IS - 1 SN - 0967-4845, 0967-4845 KW - Cytotoxins KW - 0 KW - Nucleic Acids KW - Index Medicus KW - Animals KW - Newspapers as Topic KW - United Kingdom -- epidemiology KW - Molecular Epidemiology KW - Guinea Pigs KW - Humans KW - Nucleic Acids -- genetics KW - Cytotoxins -- analysis KW - Cricetinae KW - Feces -- microbiology KW - Enterocolitis, Pseudomembranous -- diagnosis KW - Clostridium difficile -- isolation & purification KW - Enterocolitis, Pseudomembranous -- epidemiology KW - Clostridium difficile -- pathogenicity KW - Cross Infection -- epidemiology KW - Clostridium difficile -- genetics KW - Disease Outbreaks KW - Feces -- chemistry KW - Enterocolitis, Pseudomembranous -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70737461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+biomedical+science&rft.atitle=Clostridium+difficile%3A+from+obscurity+to+superbug.&rft.au=Brazier%2C+J+S&rft.aulast=Brazier&rft.aufirst=J&rft.date=2008-01-01&rft.volume=65&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=British+journal+of+biomedical+science&rft.issn=09674845&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-01 N1 - Date created - 2008-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicity of kava kava. AN - 70373909; 18322868 AB - Kava is a traditional beverage of various Pacific Basin countries. Kava has been introduced into the mainstream U.S. market principally as an anti-anxiety preparation. The effects of the long-term consumption of kava have not been documented adequately. Preliminary studies suggest possible serious organ system effects. The potential carcinogenicity of kava and its principal constituents are unknown. As such, kava extract was nominated for the chronic tumorigenicity bioassay conducted by the National Toxicology Program (NTP). At present toxicological evaluation of kava extract is being conducted by the NTP. The present review focuses on the recent findings on kava toxicity and the mechanisms by which kava induces hepatotoxicity. JF - Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews AU - Fu, Peter P AU - Xia, Qingsu AU - Guo, Lei AU - Yu, Hongtao AU - Chan, Po-Chuen AD - National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. peter.fu@fda.hhs.gov PY - 2008 SP - 89 EP - 112 VL - 26 IS - 1 KW - Plant Extracts KW - 0 KW - Index Medicus KW - Rats KW - Animals KW - Drug and Narcotic Control KW - Humans KW - Cats KW - Toxicity Tests KW - Dogs KW - Rabbits KW - Mice KW - Liver -- pathology KW - Plant Extracts -- metabolism KW - Liver -- drug effects KW - Plant Extracts -- toxicity KW - Plant Extracts -- pharmacokinetics KW - Kava -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70373909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.atitle=Toxicity+of+kava+kava.&rft.au=Fu%2C+Peter+P%3BXia%2C+Qingsu%3BGuo%2C+Lei%3BYu%2C+Hongtao%3BChan%2C+Po-Chuen&rft.aulast=Fu&rft.aufirst=Peter&rft.date=2008-01-01&rft.volume=26&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.issn=1532-4095&rft_id=info:doi/10.1080%2F10590500801907407 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-12 N1 - Date created - 2008-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10590500801907407 ER - TY - JOUR T1 - Violent behavior and DSM-IV psychiatric disorders: results from the national epidemiologic survey on alcohol and related conditions. AN - 70351342; 18312033 AB - To present nationally representative data on the lifetime prevalence and population estimates of violent behavior among individuals with DSM-IV psychiatric disorders. The data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions. Prevalences, population estimates, and associations of violent behavior occurring among individuals with pure, comorbid, and specific DSM-IV psychiatric disorders were examined. After controlling for sociodemographic characteristics and other comorbidity, it was found that the odds of violent behavior were significantly increased (p < .05) among individuals with substance use disorders; pathological gambling; major depressive disorder; bipolar disorders; panic disorder without agoraphobia; specific phobia; and paranoid, schizoid, histrionic, and obsessive-compulsive personality disorders. Percentages of violent behavior among individuals with each comorbid disorder were, with few exceptions, significantly greater (p < .05-p < .001) than the corresponding percentages among those presenting with the pure form of each disorder. Alcohol and drug use disorders were the most significant contributors to the public health burden of violent behavior. The majority of individuals with psychiatric disorders do not engage in violent behavior, and public perception associated with stereotypic violence among individuals with psychiatric disorders appears unwarranted. Elevated risks and burden of violent behavior were not equally shared across the spectrum of psychiatric disorders, with particular disorders, especially substance use disorders, contributing disproportionately to the burden. Future research should examine the circumstances under which violence among individuals with psychiatric disorders occurs with a view toward improving clinical prediction and developing more effective prevention strategies. JF - The Journal of clinical psychiatry AU - Pulay, Attila J AU - Dawson, Deborah A AU - Hasin, Deborah S AU - Goldstein, Risë B AU - Ruan, W June AU - Pickering, Roger P AU - Huang, Boji AU - Chou, S Patricia AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, Md. 20892-9304, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 12 EP - 22 VL - 69 IS - 1 KW - Index Medicus KW - Severity of Illness Index KW - Age Factors KW - Alcoholism -- diagnosis KW - Humans KW - Alcoholism -- psychology KW - Ethnic Groups -- psychology KW - Ethnic Groups -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Adult KW - Surveys and Questionnaires KW - Incidence KW - Adolescent KW - United States -- epidemiology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Prevalence KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Violence -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Mental Disorders -- psychology KW - Substance-Related Disorders -- psychology KW - Violence -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70351342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Violent+behavior+and+DSM-IV+psychiatric+disorders%3A+results+from+the+national+epidemiologic+survey+on+alcohol+and+related+conditions.&rft.au=Pulay%2C+Attila+J%3BDawson%2C+Deborah+A%3BHasin%2C+Deborah+S%3BGoldstein%2C+Ris%C3%AB+B%3BRuan%2C+W+June%3BPickering%2C+Roger+P%3BHuang%2C+Boji%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Pulay&rft.aufirst=Attila&rft.date=2008-01-01&rft.volume=69&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Subst Abuse. 1997;9:127-35 [9494944] Am J Psychiatry. 1998 Feb;155(2):226-31 [9464202] Eur Addict Res. 1998 Dec;4(4):144-9 [9852366] Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S1-6 [9857773] Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S13-23 [9857775] Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S55-60 [9857780] Alcohol Clin Exp Res. 1999 Jan;23(1):144-50 [10029216] Arch Gen Psychiatry. 2004 Nov;61(11):1107-15 [15520358] J Consult Clin Psychol. 2004 Dec;72(6):1114-21 [15612857] J Clin Psychiatry. 2005 May;66(5):564-74 [15889941] J Clin Psychiatry. 2005 Jun;66(6):677-85 [15960559] J Subst Abuse Treat. 2005 Jul;29(1):5-17 [15979527] Psychiatry Res. 2005 Sep 15;136(2-3):153-62 [16125786] Arch Gen Psychiatry. 2005 Oct;62(10):1097-106 [16203955] J Clin Psychiatry. 2005 Oct;66(10):1205-15 [16259532] Psychol Med. 2005 Dec;35(12):1747-59 [16202187] J Clin Psychiatry. 2005 Nov;66(11):1351-61 [16420070] J Clin Psychiatry. 2006 Mar;67(3):363-74 [16649821] Am J Epidemiol. 2006 Dec 15;164(12):1199-208 [17032695] Arch Gen Psychiatry. 2007 May;64(5):566-76 [17485608] Arch Gen Psychiatry. 2007 Jul;64(7):830-42 [17606817] J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491] Addiction. 1999 Jun;94(6):843-55 [10665074] Am J Drug Alcohol Abuse. 2000 May;26(2):161-77 [10852354] Arch Gen Psychiatry. 2000 Oct;57(10):979-86 [11015816] Alcohol Res Health. 2001;25(1):58-65 [11496968] Alcohol Clin Exp Res. 2003 Feb;27(2):244-52 [12605073] Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] J Clin Psychiatry. 2004 Jul;65(7):948-58 [15291684] Acta Psychiatr Scand Suppl. 2004;(424):5-59 [15447785] J Psychiatr Res. 2005 Jan;39(1):1-9 [15504418] Hosp Community Psychiatry. 1990 Jul;41(7):761-70 [2142118] Am J Psychiatry. 1990 Nov;147(11):1537-41 [2221170] Arch Gen Psychiatry. 1994 Mar;51(3):225-45 [8122959] Addiction. 1994 May;89(5):573-9 [8044123] J Consult Clin Psychol. 1995 Apr;63(2):256-62 [7751486] Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973] Epidemiol Rev. 1995;17(1):172-81 [8521935] Drug Alcohol Depend. 1997 Mar 14;44(2-3):133-41 [9088785] Psychiatry. 1997 Spring;60(1):1-22 [9130311] Drug Alcohol Depend. 1997 Sep 25;47(3):161-9 [9306042] Drug Alcohol Depend. 1997 Sep 25;47(3):171-85 [9306043] Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045] Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046] Drug Alcohol Depend. 1997 Sep 25;47(3):217-26 [9306047] Arch Gen Psychiatry. 1998 May;55(5):393-401 [9596041] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - How useful are voluntary medication error reports? The case of warfarin-related medication errors. AN - 70300757; 18277800 AB - A study was conducted to explore the value and limitations of voluntary medical error reports and to learn about common errors in warfarin use. Voluntary reports of 8,837 inpatient errors and 820 outpatient errors in warfarin use submitted by 445 hospitals and 192 outpatient facilities participating in MEDMARX, a voluntary medication error reporting system, from 2002 to 2004, were gathered. Overall, errors occurred most often during transcription/documentation (35%) and administration (30%) in hospitals, and during prescribing (31%) and dispensing (39%) in outpatient settings. Dosing errors were the most common type. In hospitals, more than 50% of reported errors were initiated by nurses, and 50% were intercepted by nurses, whereas in outpatient settings, about 50% of reported errors occurred in pharmacies and 50% were intercepted by pharmacists. About 17% of inpatient and 13% of outpatient warfarin errors resulted in changes in patient care, and 42% of inpatient and 62% of outpatient errors resulted in procedural changes. Cascade analysis and textual descriptions further located specific, correctible safety lapses. Voluntary medical error reporting systems can, to some extent, provide meaningful and actionable information to guide patient safety improvement, but their usefulness is limited because of a lack of details, incomplete reporting, underreporting, and various reporting biases. JF - Joint Commission journal on quality and patient safety AU - Zhan, Chunliu AU - Smith, Scott R AU - Keyes, Margaret A AU - Hicks, Rodney W AU - Cousins, Diane D AU - Clancy, Carolyn M AD - Agency for Healthcare Research and Quality (AHRQ), Department of Health and Human Services, Rockville, Maryland, USA. czhan@ahrq.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 36 EP - 45 VL - 34 IS - 1 SN - 1553-7250, 1553-7250 KW - Warfarin KW - 5Q7ZVV76EI KW - Index Medicus KW - United States KW - Hospitals -- standards KW - Humans KW - Quality Assurance, Health Care -- methods KW - Program Evaluation KW - Ambulatory Care Facilities -- standards KW - Truth Disclosure KW - Safety Management KW - Male KW - Female KW - Medication Errors -- classification KW - Warfarin -- adverse effects KW - Risk Management KW - Warfarin -- administration & dosage KW - Medication Errors -- statistics & numerical data KW - Voluntary Programs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70300757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Joint+Commission+journal+on+quality+and+patient+safety&rft.atitle=How+useful+are+voluntary+medication+error+reports%3F+The+case+of+warfarin-related+medication+errors.&rft.au=Zhan%2C+Chunliu%3BSmith%2C+Scott+R%3BKeyes%2C+Margaret+A%3BHicks%2C+Rodney+W%3BCousins%2C+Diane+D%3BClancy%2C+Carolyn+M&rft.aulast=Zhan&rft.aufirst=Chunliu&rft.date=2008-01-01&rft.volume=34&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Joint+Commission+journal+on+quality+and+patient+safety&rft.issn=15537250&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The potential utility of HPV genotyping in screening and clinical management. AN - 70285584; 18267061 AB - Detection of specific human papillomavirus (HPV) genotypes, or HPV genotyping, may be useful for differentiating between those women who are carcinogenic HPV-positive at lower and higher risk for cervical precancer and cancer. Considerable evidence already exists that the absolute risk for cervical precancer and cancer varies considerably among specific HPV genotypes, and that detection of HPV-16 and -18 may have clinical usefulness, especially among women who tested positive for carcinogenic HPV and have negative cytology. Detection of persistent carcinogenic HPV is strongly associated with cervical precancer and cancer and strongly predicts its development, and might be used to monitor the outcomes of HPV infections. However, several practical considerations must be addressed before HPV genotyping can be used in screening and clinical management. JF - Journal of the National Comprehensive Cancer Network : JNCCN AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 5004, EPS MSC 7234, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 83 EP - 95 VL - 6 IS - 1 SN - 1540-1405, 1540-1405 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Genotype KW - Mass Screening KW - DNA, Viral -- analysis KW - Humans KW - Decision Trees KW - Female KW - Uterine Cervical Neoplasms -- therapy KW - Cervical Intraepithelial Neoplasia -- pathology KW - Papillomavirus Infections -- diagnosis KW - Papillomavirus Infections -- virology KW - Uterine Cervical Neoplasms -- diagnosis KW - Papillomavirus Infections -- pathology KW - Cervical Intraepithelial Neoplasia -- therapy KW - Papillomaviridae -- classification KW - Papillomaviridae -- isolation & purification KW - Papillomavirus Infections -- therapy KW - Cervical Intraepithelial Neoplasia -- virology KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70285584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Comprehensive+Cancer+Network+%3A+JNCCN&rft.atitle=The+potential+utility+of+HPV+genotyping+in+screening+and+clinical+management.&rft.au=Castle%2C+Philip+E&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-01-01&rft.volume=6&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Comprehensive+Cancer+Network+%3A+JNCCN&rft.issn=15401405&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Computer-controlled ozone inhalation exposure system. AN - 70254802; 18236221 AB - Accurate systems designed to expose laboratory animals to carefully controlled concentrations of gases and aerosols are an important tool in inhalation toxicology studies. These systems are necessary for determining the dose-response relationship of toxicants under a variety of exposure conditions. The objective of this project was to develop a system, employing feedback control, to expose small laboratory animals to precise concentrations of ozone. This system needed the capability of maintaining exposures at selected levels between 0.2 to 3.0 ppm over specified periods ranging between 1 and 8 h in order to evaluate health risks associated with ozone. The overall goals of this study were (1) to develop a system capable of automatically controlling the ozone exposure levels so the steady-state error remained less than 1% and (2) to optimize the system's response time. By employing a tuned control algorithm, gas monitors, data acquisition, and a custom computer software program, these two goals were realized. JF - Inhalation toxicology AU - McKinney, Walter AU - Frazer, Dave AD - Centers for Disease Control/National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. wdm9@cdc.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 43 EP - 48 VL - 20 IS - 1 KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Software KW - Animals KW - Computer Systems KW - Atmosphere Exposure Chambers KW - Ozone -- administration & dosage KW - Ozone -- adverse effects KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70254802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Computer-controlled+ozone+inhalation+exposure+system.&rft.au=McKinney%2C+Walter%3BFrazer%2C+Dave&rft.aulast=McKinney&rft.aufirst=Walter&rft.date=2008-01-01&rft.volume=20&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958370701758544 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08958370701758544 ER - TY - JOUR T1 - Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China. AN - 70247730; 17984110 AB - Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER genes-x-ray repair cross-complementing group 1 (XRCC1) (R194W, rs1799782; R280H, rs25489 and R399Q, rs25487), apurinic/apyrimidinic endonuclease (APEX1) (D148E, rs3136820) and 8-oxoguanine DNA glycosylase (OGG1) (S326C, rs1052133), in a population-based study of 411 biliary tract cancer cases (237 gallbladder, 127 bile duct and 47 ampulla of Vater), 891 biliary (gallbladder or bile duct) stone cases and 786 population controls conducted in Shanghai, China. Compared with subjects carrying the XRCC1 194RR genotype, those with the WW genotype had a 1.9-fold risk of bile duct cancer [odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.5, P(trend) = 0.03], and compared with subjects carrying the XRCC1 280RR genotype, those with the XRCC1 280H allele had a 50% reduced risk of bile duct cancer (OR = 0.5, 95% CI = 0.3-0.9, P(trend) = 0.05). The effect of the R280H polymorphism persisted (P(trend) = 0.03), when all three XRCC1 polymorphisms were jointly considered in the model, a finding supported by the haplotype results (covariate-adjusted global permutation P = 0.03). We also found an inverse association between the APEX1 148E allele and gallbladder stones (P(trend) = 0.03), but no association for the OGG1 polymorphism. This study suggests that genetic variants in XRCC1 and APEX1 may alter susceptibility to biliary tract cancer and stones. Further studies are required to confirm the reported associations. JF - Carcinogenesis AU - Huang, Wen-Yi AU - Gao, Yu-Tang AU - Rashid, Asif AU - Sakoda, Lori C AU - Deng, Jie AU - Shen, Ming-Chang AU - Wang, Bin-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Chen, Bingshu E AU - Rosenberg, Philip S AU - Chanock, Stephen J AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 100 EP - 105 VL - 29 IS - 1 KW - Index Medicus KW - Genotype KW - Humans KW - China -- epidemiology KW - Case-Control Studies KW - DNA Repair -- genetics KW - Gallstones -- epidemiology KW - Biliary Tract Neoplasms -- epidemiology KW - Polymorphism, Genetic KW - Biliary Tract Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - Gallstones -- genetics KW - Population Surveillance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70247730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Selected+base+excision+repair+gene+polymorphisms+and+susceptibility+to+biliary+tract+cancer+and+biliary+stones%3A+a+population-based+case-control+study+in+China.&rft.au=Huang%2C+Wen-Yi%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BSakoda%2C+Lori+C%3BDeng%2C+Jie%3BShen%2C+Ming-Chang%3BWang%2C+Bin-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip+S%3BChanock%2C+Stephen+J%3BHsing%2C+Ann+W&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2008-01-01&rft.volume=29&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-31 N1 - Date created - 2008-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Application of oligonucleotide microarray technology to toxic occupational exposures. AN - 70242100; 18214805 AB - Microarray technology has advanced toward analysis of toxic occupational exposures in biological systems. Microarray analysis is an ideal way to search for biomarkers of exposure, even if no specific gene or pathway has been identified. Analysis may now be performed on thousands of genes simultaneously, as opposed to small numbers of genes as in the past. This ability has been put to use to analyze gene expression profiles of a variety of occupational toxins in animal models to classify toxins into specific categories based on response. Analysis of normal human cell strains allows an extension of this analysis to investigate the role of interindividual variation in response to various toxins. This methodology was used to analyze four occupationally related toxins in our lab: oxythioquinox (OTQ), a quinoxaline pesticide; malathion, an organophosphate pesticide; di-n-butyl phthalate (DBP), a chemical commonly found in personal care and cosmetic items; and benzo[a]pyrene (BaP), an environmental and occupational carcinogen. The results for each exposure highlighted signaling pathways involved in response to these occupational exposures. Both pesticides showed increase in metabolic enzymes, while DBP showed alterations in genes related to fertility. BaP exposure showed alterations in two cytochrome P450s related to carcinogenicity. When used with occupational exposure information, these data may be used to augment risk assessment to make the workplace safer for a greater proportion of the workforce, including individuals susceptible to disease related to exposures. JF - Journal of toxicology and environmental health. Part A AU - Gwinn, Maureen R AU - Weston, Ainsley AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 315 EP - 324 VL - 71 IS - 5 SN - 1528-7394, 1528-7394 KW - Carcinogens, Environmental KW - 0 KW - Pesticides KW - Plasticizers KW - Quinoxalines KW - Dibutyl Phthalate KW - 2286E5R2KE KW - quinomethionate KW - 2439-01-2 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Malathion KW - U5N7SU872W KW - Index Medicus KW - Benzo(a)pyrene -- pharmacology KW - Cytochrome P-450 Enzyme System -- genetics KW - Humans KW - Pesticides -- pharmacology KW - Risk Assessment KW - Environmental Monitoring KW - Malathion -- pharmacology KW - Genes, p53 KW - Signal Transduction -- genetics KW - Dibutyl Phthalate -- pharmacology KW - Plasticizers -- pharmacology KW - Quinoxalines -- pharmacology KW - Cell Line KW - Mammary Glands, Human -- drug effects KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis KW - Occupational Exposure -- adverse effects KW - Carcinogens, Environmental -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70242100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Application+of+oligonucleotide+microarray+technology+to+toxic+occupational+exposures.&rft.au=Gwinn%2C+Maureen+R%3BWeston%2C+Ainsley&rft.aulast=Gwinn&rft.aufirst=Maureen&rft.date=2008-01-01&rft.volume=71&rft.issue=5&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390701738509 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-06 N1 - Date created - 2008-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15287390701738509 ER - TY - JOUR T1 - Determination of caffeine and sympathomimetic alkaloids in weight loss supplements by high-performance liquid chromatography. AN - 70240570; 18218190 AB - Reversed-phase high-performance liquid chromatography utilizing photodiode array detection is used for the simultaneous determination of caffeine and nine alkaloids from Citrus aurantium (CA) and ephedra (EA) contained in dietary weight loss products. Since the Food and Drug Administration (FDA) ban of EA, manufacturers have substituted CA in their weight loss formulations, usually combined with high levels of caffeine. The alkaloids contained in CA have some physiological effects similar to those of the EA alkaloids and are, therefore, cause for concern. Caffeine has been shown to potentiate the toxicity of the EA alkaloids. Recently, a federal judge overturned the absolute ban and allowed marketing of low levels (<10 mg/day) of total EA alkaloids. To support an absolute ban, the FDA is now compelled to perform dose-dependent toxicology studies to determine the toxic dose(s) of EA. The toxicity of the CA compounds is largely unknown, especially in combination with caffeine. The described method enables quantitation over a wide range of product formulations. Recoveries range from 91% to 100% from a variety of fortified plant matrices. JF - Journal of chromatographic science AU - Evans, Ronald L AU - Siitonen, Paul H AD - National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Division of Biochemical Toxicology, Jefferson, AR 72079, USA. ronald.evans@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 61 EP - 67 VL - 46 IS - 1 SN - 0021-9665, 0021-9665 KW - Alkaloids KW - 0 KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Reproducibility of Results KW - Chromatography, High Pressure Liquid -- methods KW - Caffeine -- analysis KW - Alkaloids -- analysis KW - Dietary Supplements -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70240570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatographic+science&rft.atitle=Determination+of+caffeine+and+sympathomimetic+alkaloids+in+weight+loss+supplements+by+high-performance+liquid+chromatography.&rft.au=Evans%2C+Ronald+L%3BSiitonen%2C+Paul+H&rft.aulast=Evans&rft.aufirst=Ronald&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatographic+science&rft.issn=00219665&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-05 N1 - Date created - 2008-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents. AN - 70239595; 17879298 AB - Hepatocellular carcinoma, which is one of the most prevalent life-threatening human cancers, is showing an increased incidence worldwide. Recent evidence indicates that the development of hepatocellular carcinoma is associated with not only genetic alterations, but also with profound epigenetic changes. This review summarizes the current knowledge about epigenetic alterations during rodent hepatocarcinogenesis, considers the similarities and differences in epigenetic effects of genotoxic and non-genotoxic rodent liver carcinogens, and discusses the possible role of these effects in the causality of liver tumor development. JF - Environmental and molecular mutagenesis AU - Pogribny, Igor P AU - Rusyn, Ivan AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. igor.pogribny@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 9 EP - 15 VL - 49 IS - 1 SN - 0893-6692, 0893-6692 KW - Index Medicus KW - Animals KW - DNA Damage KW - Humans KW - Disease Models, Animal KW - Rodentia KW - Carcinoma, Hepatocellular -- genetics KW - Liver Neoplasms -- physiopathology KW - Carcinoma, Hepatocellular -- physiopathology KW - Epigenesis, Genetic KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70239595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Epigenetic+aspects+of+genotoxic+and+non-genotoxic+hepatocarcinogenesis%3A+studies+in+rodents.&rft.au=Pogribny%2C+Igor+P%3BRusyn%2C+Ivan%3BBeland%2C+Frederick+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2008-01-01&rft.volume=49&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-28 N1 - Date created - 2008-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Surg Res. 2006 Nov;136(1):125-35 [17023002] Pathol Int. 1999 Dec;49(12):1028-42 [10632923] Cell. 2007 Feb 23;128(4):683-92 [17320506] Mol Carcinog. 2007 Mar;46(3):187-97 [17219426] Cell. 2000 Jan 7;100(1):57-70 [10647931] Toxicol Sci. 2000 Apr;54(2):399-407 [10774822] J Environ Pathol Toxicol Oncol. 2000;19(3):281-6 [10983894] Regul Toxicol Pharmacol. 2000 Oct;32(2):135-43 [11067770] Mol Carcinog. 2001 Mar;30(3):138-50 [11301474] Toxicol Sci. 2001 Jul;62(1):28-35 [11399790] Annu Rev Pharmacol Toxicol. 2002;42:501-25 [11807181] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Toxicol Lett. 2002 Aug 5;134(1-3):51-6 [12191860] Cancer Lett. 2002 Dec 10;187(1-2):69-75 [12359353] Int J Cancer. 2003 Jul 1;105(4):527-32 [12712445] Exp Cell Res. 2003 Jun 10;286(2):355-65 [12749863] Am J Pathol. 2003 Sep;163(3):1101-7 [12937151] Am J Pathol. 2003 Oct;163(4):1371-8 [14507645] Oncogene. 2003 Sep 25;22(41):6319-31 [14508512] J Nutr. 2003 Nov;133(11 Suppl 1):3740S-3747S [14608108] J Natl Cancer Inst. 2003 Dec 3;95(23):1747-57 [14652236] Mutat Res. 2003 Dec 10;533(1-2):37-65 [14643412] Adv Cancer Res. 2003;90:209-30 [14710952] Nat Rev Cancer. 2004 Feb;4(2):143-53 [14732866] EMBO J. 2004 Feb 11;23(3):605-15 [14765126] Science. 2004 Mar 12;303(5664):1626-32 [15016989] Mutat Res. 2004 Apr 14;548(1-2):53-9 [15063136] Toxicol Lett. 2004 Apr 1;149(1-3):51-8 [15093248] Carcinogenesis. 2004 Sep;25(9):1779-86 [15073043] Lab Invest. 2004 Sep;84(9):1137-47 [15220935] Semin Cancer Biol. 2004 Dec;14(6):427-32 [15489135] Carcinogenesis. 1989 May;10(5):933-7 [2650909] Biochem Pharmacol. 1991 Jul 5;42(2):365-71 [1859451] Cancer Res. 1992 Apr 1;52(7 Suppl):2071s-2077s [1544143] Cancer Res. 1992 Sep 15;52(18):5042-5 [1516060] Trends Genet. 1997 Aug;13(8):335-40 [9260521] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10907-12 [9380733] Hepatogastroenterology. 1998 Sep-Oct;45(23):1753-9 [9840141] Mutat Res. 1999 Mar 8;424(1-2):97-106 [10064853] Cell. 2004 Nov 24;119(5):603-14 [15550243] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] Liver Int. 2005 Feb;25(1):16-27 [15698394] Nat Genet. 2005 Apr;37(4):391-400 [15765097] Eur J Gastroenterol Hepatol. 2005 May;17(5):477-83 [15827436] Annu Rev Biochem. 2005;74:481-514 [15952895] Carcinogenesis. 2005 Aug;26(8):1323-34 [15802302] Hepatology. 2005 Nov;42(5):1137-47 [16250055] EXS. 2006;(96):321-49 [16383025] Mutat Res. 2006 Jan 29;593(1-2):80-7 [16144704] Cancer Lett. 2006 Feb 28;233(2):271-8 [15885882] Toxicol Sci. 2006 Apr;90(2):317-25 [16396840] J Nutr. 2006 Jun;136(6):1522-7 [16702315] Carcinogenesis. 2006 Jun;27(6):1180-6 [16497704] FEBS J. 2006 Jul;273(14):3121-35 [16857008] Curr Top Microbiol Immunol. 2006;310:211-50 [16909913] Mol Carcinog. 2007 Apr;46(4):269-74 [17295234] Oncogene. 2007 Apr 2;26(15):2166-76 [17401425] Hum Mol Genet. 2007 Jun 1;16(11):1335-42 [17412760] Cancer Res. 2007 Jun 15;67(12):5583-6 [17575120] Mutagenesis. 2007 Jul;22(4):247-53 [17412712] Mutat Res. 2007 Dec 1;625(1-2):62-71 [17586532] Toxicol Sci. 2007 Mar;96(1):72-82 [17172636] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of food-allergic and anaphylactic events in the National Electronic Injury Surveillance System. AN - 70219372; 18206508 AB - The National Electronic Injury Surveillance System (NEISS) captures a nationally representative probability sample from hospital emergency departments (EDs) in the United States. Emergency department data from NEISS were analyzed to assess the magnitude and severity of adverse events attributable to food allergies. Emergency department events describing food-related allergic symptomatology were identified from 34 participating EDs from August 1 to September 30, 2003. Extrapolation of NEISS event data predicts a total of 20,821 hospital ED visits, 2333 visits for anaphylaxis, and 520 hospitalizations caused by food allergy in the United States during the 2-month study period. The median age was 26 years; 24% of visits involved children or =6 years old, whereas children < or =5 years old experienced more events from eggs, fruit, peanuts, and tree nuts. There were no reported deaths. Review of medical records found that only 19% of patients received epinephrine, and, using criteria established by a 2005 anaphylaxis symposium, 57% of likely anaphylactic events did not have an ED diagnosis of anaphylaxis. Analysis of NEISS data may be a useful tool for assessing the magnitude and severity of food-allergic events. A criteria-based review of medical records suggests underdiagnosis of anaphylactic events in EDs. JF - The Journal of allergy and clinical immunology AU - Ross, Marianne Phelan AU - Ferguson, Martine AU - Street, Debra AU - Klontz, Karl AU - Schroeder, Tom AU - Luccioli, Stefano AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA. Marianne.Ross@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 166 EP - 171 VL - 121 IS - 1 KW - Abridged Index Medicus KW - Index Medicus KW - Anaphylaxis -- epidemiology KW - Nuts -- adverse effects KW - Food Hypersensitivity -- etiology KW - Food Hypersensitivity -- epidemiology KW - Humans KW - Child KW - Fruit -- adverse effects KW - Child, Preschool KW - Infant KW - Shellfish -- adverse effects KW - Eggs -- adverse effects KW - Peanut Hypersensitivity KW - Adult KW - Anaphylaxis -- etiology KW - Emergency Service, Hospital -- statistics & numerical data KW - Adolescent KW - Hospitalization -- statistics & numerical data KW - United States -- epidemiology KW - Adverse Drug Reaction Reporting Systems KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70219372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Analysis+of+food-allergic+and+anaphylactic+events+in+the+National+Electronic+Injury+Surveillance+System.&rft.au=Ross%2C+Marianne+Phelan%3BFerguson%2C+Martine%3BStreet%2C+Debra%3BKlontz%2C+Karl%3BSchroeder%2C+Tom%3BLuccioli%2C+Stefano&rft.aulast=Ross&rft.aufirst=Marianne&rft.date=2008-01-01&rft.volume=121&rft.issue=1&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/10.1016%2Fj.jaci.2007.10.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-25 N1 - Date created - 2008-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jaci.2007.10.012 ER - TY - JOUR T1 - Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies. AN - 70211274; 18197312 AB - Conflicting views have been expressed frequently on assessments of human cancer risk of environmental agents based on animal carcinogenicity data; this is primarily because of uncertainties associated with extrapolations of toxicologic findings from studies in experimental animals to human circumstances. Underlying these uncertainties are issues related to how experiments are designed, how rigorously hypotheses are tested, and to what extent assertions extend beyond actual findings. National and international health agencies regard carcinogenicity findings in well-conducted experimental animal studies as evidence of potential carcinogenic risk to humans. Controversies arise when both positive and negative carcinogenicity data exist for a specific agent or when incomplete mechanistic data suggest a possible species difference in response. Issues of experimental design and evaluation that might contribute to disparate results are addressed in this article. To serve as reliable sources of data for the evaluation of the carcinogenic potential of environmental agents, experimental studies must include a) animal models that are sensitive to the end points under investigation; b) detailed characterization of the agent and the administered doses; c) challenging doses and durations of exposure (at least 2 years for rats and mice); d) sufficient numbers of animals per dose group to be capable of detecting a true effect; e) multiple dose groups to allow characterization of dose-response relationships, f) complete and peer-reviewed histopathologic evaluations; and g) pairwise comparisons and analyses of trends based on survival-adjusted tumor incidence. Pharmacokinetic models and mechanistic hypotheses may provide insights into the biological behavior of the agent; however, they must be adequately tested before being used to evaluate human cancer risk. JF - Environmental health perspectives AU - Melnick, Ronald L AU - Thayer, Kristina A AU - Bucher, John R AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. melnickr@niehs.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 130 EP - 135 VL - 116 IS - 1 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - tumor pathology KW - maximally tolerated dose KW - statistical power KW - mode of action KW - rodent cancer bioassay KW - dose selection KW - Rats KW - Animals KW - Public Health KW - Dose-Response Relationship, Drug KW - Humans KW - Carcinogenicity Tests -- methods KW - Mice KW - Research Design KW - Risk Assessment KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70211274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Conflicting+views+on+chemical+carcinogenesis+arising+from+the+design+and+evaluation+of+rodent+carcinogenicity+studies.&rft.au=Melnick%2C+Ronald+L%3BThayer%2C+Kristina+A%3BBucher%2C+John+R&rft.aulast=Melnick&rft.aufirst=Ronald&rft.date=2008-01-01&rft.volume=116&rft.issue=1&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9989 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Natl Toxicol Program Tech Rep Ser. 2006 Feb;(533):1-264 [16741556] J Cancer Res Clin Oncol. 1999;125(3-4):219-25 [10235477] Carcinogenesis. 2000 Apr;21(4):823-6 [10753222] J Cancer Res Clin Oncol. 2000 Apr;126(4):246 [10782899] IARC Monogr Eval Carcinog Risks Hum. 1999;73:339-83 [10804962] Environ Health Perspect. 2000 May;108 Suppl 2:265-73 [10807557] Environ Health Perspect. 2000 May;108 Suppl 2:283-305 [10807559] Toxicol Sci. 2000 Jun;55(2):433-43 [10828276] IARC Monogr Eval Carcinog Risks Hum. 2000;77:41-148 [11100399] FASEB J. 2001 Jan;15(1):195-203 [11149907] Food Chem Toxicol. 2001 Jul;39(7):739-44 [11397520] Environ Health Perspect. 2001 May;109(5):437-42 [11401753] Toxicol Pathol. 1984;12(2):126-35 [11478313] Int J Occup Environ Health. 2002 Apr-Jun;8(2):144-52 [12019681] Br J Cancer. 2003 Jan 13;88(1):84-9 [12556964] Ann N Y Acad Sci. 2002 Dec;982:177-89 [12562636] Toxicol Sci. 2003 Sep;75(1):7-15 [12805639] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] Environ Health Perspect. 2004 Sep;112(13):1269-74 [15345338] Arch Toxicol. 1977 Jul 19;37(3):233-6 [332116] Natl Cancer Inst Monogr. 1979 May;(51):25-35 [481577] Food Chem Toxicol. 1983 Dec;21(6):825-32 [6363233] Arch Toxicol. 1984 Oct;55(4):213-8 [6517696] Environ Health Perspect. 1984 Dec;58:385-92 [6525993] Toxicol Pathol. 1983;11(1):77-82 [6681400] J Natl Cancer Inst. 1986 Feb;76(2):283-9 [3456066] Am Ind Hyg Assoc J. 1987 May;48(5):407-13 [3591659] Fundam Appl Toxicol. 1988 Apr;10(3):385-94 [3286346] Cancer Res. 1988 Dec 1;48(23):6739-44 [3180084] Environ Health Perspect. 1989 Jul;82:109-24 [2792037] Environ Health Perspect. 1989 Jul;82:125-63 [2676495] IARC Sci Publ. 1989;(96):17-34 [2553598] Occup Environ Med. 1999 Mar;56(3):181-90 [10448327] IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 1:109-225 [10476446] N Engl J Med. 2005 Jul 14;353(2):116-8 [16014880] Natl Toxicol Program Tech Rep Ser. 2005 Sep;(494):1-358 [16362060] Natl Toxicol Program Tech Rep Ser. 2005 Dec;(517):1-255 [16362061] Cancer Res. 1990 Oct 15;50(20):6592-9 [2208121] Rev Environ Contam Toxicol. 1992;124:111-44 [1732994] Chem Res Toxicol. 1991 Mar-Apr;4(2):168-79 [1664256] Biochemistry. 1993 Jun 1;32(21):5598-604 [7684926] IARC Monogr Eval Carcinog Risks Hum. 1994;60:73-159 [7869582] Toxicol Pathol. 1994 Sep-Oct;22(5):457-72 [7899775] Fundam Appl Toxicol. 1995 Aug;27(1):95-105 [7589934] Toxicol Lett. 1995 Sep;79(1-3):107-14 [7570646] Biochim Biophys Acta. 1996 Jul 26;1302(2):93-109 [8695669] Fundam Appl Toxicol. 1996 May;31(1):1-8 [8998945] Ann N Y Acad Sci. 1996 Dec 27;804:252-65 [8993548] J Appl Toxicol. 1997 May;17 Suppl 1:S45-55 [9179727] IARC Monogr Eval Carcinog Risks Hum. 1997;69:33-343 [9336729] Med Hypotheses. 1998 Jun;50(6):525-9 [9710329] J Occup Health. 2007 May;49(3):172-82 [17575397] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.9989 ER - TY - JOUR T1 - Ultrafine and respirable particles in an automotive grey iron foundry. AN - 70206585; 18056626 AB - Ultrafine particle number and respirable particle mass concentrations were measured throughout an automotive grey iron foundry during winter, spring and summer using a particle concentration mapping procedure. Substantial temporal and spatial variability was observed in all seasons and attributed, in part, to the batch nature of operations, process emission variability and frequent work interruptions. The need for fine mapping grids was demonstrated, where elevations in particle concentrations were highly localized. Ultrafine particle concentrations were generally greatest during winter when incoming make-up air was heated with direct fire, natural gas burners. Make-up air drawn from roof level had elevated respirable mass and ultrafine number concentrations above ambient outdoor levels, suggesting inadvertent recirculation of foundry process emissions. Elevated respirable mass concentrations were highly localized on occasions (e.g. abrasive blasting and grinding), depended on the area within the facility where measurements were obtained, but were largely unaffected by season. Particle sources were further characterized by measuring their respective number and mass concentrations by particle size. Sources that contributed to ultrafine particles included process-specific sources (e.g. melting and pouring operations), and non-process sources (e.g. direct fire natural gas heating units, a liquid propane-fuelled sweeper and cigarette smoking) were additionally identified. JF - The Annals of occupational hygiene AU - Evans, Douglas E AU - Heitbrink, William A AU - Slavin, Thomas J AU - Peters, Thomas M AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R3, Cincinnati, OH 45226, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 9 EP - 21 VL - 52 IS - 1 SN - 0003-4878, 0003-4878 KW - Air Pollutants, Occupational KW - 0 KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Inhalation Exposure -- analysis KW - Particle Size KW - Humans KW - Seasons KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- methods KW - Air Pollutants, Occupational -- analysis KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70206585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Ultrafine+and+respirable+particles+in+an+automotive+grey+iron+foundry.&rft.au=Evans%2C+Douglas+E%3BHeitbrink%2C+William+A%3BSlavin%2C+Thomas+J%3BPeters%2C+Thomas+M&rft.aulast=Evans&rft.aufirst=Douglas&rft.date=2008-01-01&rft.volume=52&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of the CATHIA-T sampler, the GK2.69 cyclone and the standard cowled sampler for thoracic fiber concentrations at a Taconite (iron ore)-processing mill. AN - 70205767; 18195326 AB - Several recommendations have been made to the effect that the most appropriate health-based size-selective criterion for fibers is the thoracic convention of the International Organization for Standardization (ISO). The performance of two thoracic samplers, the CATHIA-T (37-mm filter) and the GK2.69 cyclone (37-mm filter), was investigated against the standard 25-mm cowled sampler (current NIOSH 7400 standard method) to determine the effect of thoracic sampling on field results. A total of 270 samples: 80 field and 10 field blank samples for each sampler type, were taken from seven stations in the processing mill of an iron ore mine whose ore contains amphibole minerals. Slides were prepared using the dimethyl formamide/Euparal technique and relocatable cover slips. Two counters examined the slides according to NIOSH 7400 counting A rules with phase contrast microscopes. Prior to counting the sample slides, four reference slides were randomly selected and counted three times on different days to compare the coefficient of variation (CV) between and within counters. Also, seven reference slides were chosen to explore variability between the two microscopes. The average CV between counters (0.148) showed slightly higher than the average CVs within counters (0.072 for Counter 1 and 0.119 for Counter 2). The average CV between the two microscopes was 0.147. Compared to the standard cowled sampler, the overall fiber concentration was lower for the CATHIA-T sampler (CATHIA-T/Cowled = 0.63) and higher for the GK2.69 cyclone (GK2.69/Cowled = 1.66). The result for the CATHIA-T sampler is as expected from laboratory trials, but the result for the GK2.69 cyclone is not as expected. In conclusion, the CATHIA-T sampler has a potential advantage as a high-flow static sampler for screening coarse particles. However, these findings resulted from one field sampling site that contains amphibole minerals, not all of which are asbestiform. Thus, additional field samples from other environments might be helpful to confirm the performance of these samplers. JF - The Annals of occupational hygiene AU - Lee, Eun Gyung AU - Harper, Martin AU - Nelson, John AU - Hintz, Patrick J AU - Andrew, Michael E AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS-3030, Morgantown, WV 26505, USA. elee2@cdc.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 55 EP - 62 VL - 52 IS - 1 SN - 0003-4878, 0003-4878 KW - Air Pollutants, Occupational KW - 0 KW - Mineral Fibers KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Reproducibility of Results KW - Inhalation Exposure -- analysis KW - Particle Size KW - Humans KW - Mineral Fibers -- analysis KW - Air Pollutants, Occupational -- analysis KW - Metallurgy KW - Environmental Monitoring -- methods KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70205767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=A+comparison+of+the+CATHIA-T+sampler%2C+the+GK2.69+cyclone+and+the+standard+cowled+sampler+for+thoracic+fiber+concentrations+at+a+Taconite+%28iron+ore%29-processing+mill.&rft.au=Lee%2C+Eun+Gyung%3BHarper%2C+Martin%3BNelson%2C+John%3BHintz%2C+Patrick+J%3BAndrew%2C+Michael+E&rft.aulast=Lee&rft.aufirst=Eun&rft.date=2008-01-01&rft.volume=52&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/10.1093%2Fannhyg%2Fmem062 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mem062 ER - TY - JOUR T1 - Identification of mold and dampness-associated respiratory morbidity in 2 schools: comparison of questionnaire survey responses to national data. AN - 70188533; 18177298 AB - Dampness and mold problems are frequently encountered in schools. Approximately one third of US public schools require extensive repairs or need at least 1 building replaced. This study illustrates how national data can be used to identify building-related health risks in school employees and students. School employees (n = 309) in 2 elementary schools (schools A and B) with dampness and mold problems completed standardized questionnaires. Responses were compared with participant responses from the 3rd National Health and Nutrition Examination Survey and were indirectly standardized for gender, age, smoking status, and (for school B) race. Uncontrolled comparisons were made to responses from a study of office workers, as well as between responses from school employees in different sections of the school buildings designated by decade of construction. Employees from both schools had excess work-related throat and lower respiratory symptoms, as well as eye, nasal, sinus, and wheezing symptoms. School B employees also had excess physician-diagnosed asthma and work-related fatigue, headache, and skin irritation. Employees in sections of the school buildings that were categorized as having greater dampness and mold contamination had more frequent upper and lower respiratory symptoms than employees working in other building sections. This noncostly type of analysis of indoor air quality complaints can be used to motivate and prioritize building remediation in public schools where funds for building remediation are usually limited. JF - The Journal of school health AU - Sahakian, Nancy M AU - White, Sandra K AU - Park, Ju-Hyeong AU - Cox-Ganser, Jean M AU - Kreiss, Kathleen AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505, USA. nsahakian@cdc.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 32 EP - 37 VL - 78 IS - 1 SN - 0022-4391, 0022-4391 KW - Index Medicus KW - Nursing KW - Air Pollution, Indoor -- adverse effects KW - Humans KW - Adult KW - Middle Aged KW - Environmental Exposure -- adverse effects KW - Male KW - Female KW - Schools KW - Fungi KW - Respiratory Tract Diseases -- etiology KW - Humidity -- adverse effects KW - Health Surveys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70188533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+school+health&rft.atitle=Identification+of+mold+and+dampness-associated+respiratory+morbidity+in+2+schools%3A+comparison+of+questionnaire+survey+responses+to+national+data.&rft.au=Sahakian%2C+Nancy+M%3BWhite%2C+Sandra+K%3BPark%2C+Ju-Hyeong%3BCox-Ganser%2C+Jean+M%3BKreiss%2C+Kathleen&rft.aulast=Sahakian&rft.aufirst=Nancy&rft.date=2008-01-01&rft.volume=78&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+school+health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fj.1746-1561.2007.00263.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2008-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1746-1561.2007.00263.x ER - TY - JOUR T1 - NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation. AN - 70182404; 17986233 AB - A novel radioligand, 6-chloro-3-((2-(S)-azetidinyl)methoxy)-5-(2-fluoropyridin-4-yl)pyridine (NIDA522131), for imaging extrathalamic nicotinic acetylcholine receptors (nAChRs) was characterized in vitro and in vivo using positron emission tomography. The K(d) and T(1/2) of dissociation of NIDA522131 binding measured at 37 degrees C in vitro were 4.9 +/- 0.4 pmol/L and 81 +/- 5 min, respectively. The patterns of radioactivity distribution in monkey brain in vivo was similar to that of 2-[(18)F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2FA), a radioligand that has been successfully used in humans, and matched the alpha(4)beta(2)* nAChRs distribution. Comparison between [(18)F]NIDA522131 and 2FA demonstrated better in vivo binding properties of the new radioligand and substantially greater radioactivity accumulation in brain. Consistent with [(18)F]NIDA522131 elevated affinity for nAChRs and its increased lipophilicity, both, the total and non-displaceable distribution volumes were substantially higher than those of 2FA. Estimated binding potential values in different brain regions, characterizing the specificity of receptor binding, were 3-4 fold higher for [(18)F]NIDA522131 than those of 2FA. Pharmacological evaluation in mice demonstrated a toxicity that was comparable to 2FA and is in agreement with a 2300 fold higher affinity at alpha(4)beta(2)* versus alpha(3)beta(4)* nAChRs. These results suggest that [(18)F]NIDA522131 is a promising positron emission tomography radioligand for studying extrathalamic nAChR in humans. JF - Journal of neurochemistry AU - Chefer, Svetlana I AU - Pavlova, Olga A AU - Zhang, Yi AU - Vaupel, D Bruce AU - Kimes, Alane S AU - Horti, Andrew G AU - Stein, Elliot AU - Mukhin, Alexey G AD - Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 306 EP - 315 VL - 104 IS - 2 KW - 6-chloro-3-((2-azetidinyl)methoxy)-5-(2-fluoropyridin-5-yl)pyridine KW - 0 KW - Azetidines KW - Fluorine Radioisotopes KW - Pyridines KW - Radiopharmaceuticals KW - Receptors, Nicotinic KW - Index Medicus KW - Animals KW - Positron-Emission Tomography -- methods KW - Dose-Response Relationship, Drug KW - Binding, Competitive -- drug effects KW - Mice KW - Autoradiography KW - Rats KW - Evaluation Studies as Topic KW - Behavior, Animal -- drug effects KW - Plasma -- drug effects KW - In Vitro Techniques KW - Macaca mulatta KW - Motor Activity -- drug effects KW - Male KW - Azetidines -- chemistry KW - Thalamus -- diagnostic imaging KW - Pyridines -- chemistry KW - Fluorine Radioisotopes -- pharmacokinetics KW - Radiopharmaceuticals -- pharmacology KW - Radiopharmaceuticals -- chemical synthesis KW - Receptors, Nicotinic -- drug effects KW - Radiopharmaceuticals -- chemistry KW - Azetidines -- pharmacology KW - Pyridines -- pharmacology KW - Fluorine Radioisotopes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70182404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=NIDA522131%2C+a+new+radioligand+for+imaging+extrathalamic+nicotinic+acetylcholine+receptors%3A+in+vitro+and+in+vivo+evaluation.&rft.au=Chefer%2C+Svetlana+I%3BPavlova%2C+Olga+A%3BZhang%2C+Yi%3BVaupel%2C+D+Bruce%3BKimes%2C+Alane+S%3BHorti%2C+Andrew+G%3BStein%2C+Elliot%3BMukhin%2C+Alexey+G&rft.aulast=Chefer&rft.aufirst=Svetlana&rft.date=2008-01-01&rft.volume=104&rft.issue=2&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2008-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improving women's health through modernization of our bioinformatics infrastructure. AN - 70167949; 17987048 AB - Our nationwide bioinformatics infrastructure used to detect important sex differences associated with medical product use is antiquated. The Food and Drug Administration (FDA) has embarked on an ambitious bioinformatics modernization effort that will improve our ability to assess the safety and effectiveness of new medical products. This, in turn, will improve our ability to detect important sex differences. JF - Clinical pharmacology and therapeutics AU - Oliva, A AU - Pinnow, E AU - Levin, R AU - Uhl, K AD - Office of Critical Path Programs, Food and Drug Administration, Rockville, Maryland, USA. armando.oliva@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 192 EP - 195 VL - 83 IS - 1 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Consumer Product Safety KW - Sex Factors KW - Humans KW - Information Dissemination KW - Program Development KW - Health Knowledge, Attitudes, Practice KW - Clinical Trials as Topic KW - Patient Selection KW - Male KW - Female KW - Risk Assessment KW - Women's Health KW - Drug-Related Side Effects and Adverse Reactions KW - United States Food and Drug Administration -- organization & administration KW - Computational Biology -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70167949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Improving+women%27s+health+through+modernization+of+our+bioinformatics+infrastructure.&rft.au=Oliva%2C+A%3BPinnow%2C+E%3BLevin%2C+R%3BUhl%2C+K&rft.aulast=Oliva&rft.aufirst=A&rft.date=2008-01-01&rft.volume=83&rft.issue=1&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-24 N1 - Date created - 2007-12-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score. AN - 70166527; 17855015 AB - To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) score. Patients with localized prostate cancer received amifostine as a rectal suspension 30-45 minutes before daily three-dimensional conformal radiation therapy. The first 18 patients received 1 g of amifostine, and the next 12 patients received 2 g. Toxicity was assessed at baseline, during treatment, and at follow-up visits by using RTOG grading and the EPIC Quality of Life (QoL) 50-item questionnaire. The Bowel Function subset of the bowel domain (EPIC-BF), which targets symptom severity, and the Bowel Bother subset of the bowel domain (EPIC-BB), which assesses QoL, were evaluated and compared with the RTOG GI toxicity score. Median follow-up was 30 months (range, 18-36 months). Overall, EPIC-BF and EPIC-BB scores both tracked closely with the RTOG GI toxicity score. Seven weeks after the start of radiation therapy, the incidence of RTOG Grade 2 toxicity was 33% in the 1-g group (6/18 patients) compared with 0% (0/12 patients) in the 2-g group and tended toward statistical significance (p = 0.06). A significant difference between amifostine groups was observed using the EPIC-BF score at 7 weeks (p = 0.04). A difference in EPIC-BB scores between dose groups was evident at 7 weeks (p = 0.07) and was significant at 12 months (p = 0.04). Higher doses of amifostine produced significant improvements in acute and late bowel QoL (up to 1 year after therapy), measured using the EPIC score. JF - International journal of radiation oncology, biology, physics AU - Simone, Nicole L AU - Ménard, Cynthia AU - Soule, Benjamin P AU - Albert, Paul S AU - Guion, Peter AU - Smith, Sharon AU - Godette, Denise AU - Crouse, Nancy S AU - Sciuto, Linda C AU - Cooley-Zgela, Theresa AU - Camphausen, Kevin AU - Coleman, C Norman AU - Singh, Anurag K AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 90 EP - 95 VL - 70 IS - 1 SN - 0360-3016, 0360-3016 KW - Radiation-Protective Agents KW - 0 KW - Amifostine KW - M487QF2F4V KW - Index Medicus KW - Severity of Illness Index KW - Dose-Response Relationship, Drug KW - Radiation Injuries -- prevention & control KW - Humans KW - Rectum -- radiation effects KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Administration, Rectal KW - Male KW - Adenocarcinoma -- radiotherapy KW - Radiation-Protective Agents -- administration & dosage KW - Quality of Life KW - Proctitis -- prevention & control KW - Amifostine -- administration & dosage KW - Prostatic Neoplasms -- radiotherapy KW - Radiotherapy, Conformal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70166527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Intrarectal+amifostine+during+external+beam+radiation+therapy+for+prostate+cancer+produces+significant+improvements+in+Quality+of+Life+measured+by+EPIC+score.&rft.au=Simone%2C+Nicole+L%3BM%C3%A9nard%2C+Cynthia%3BSoule%2C+Benjamin+P%3BAlbert%2C+Paul+S%3BGuion%2C+Peter%3BSmith%2C+Sharon%3BGodette%2C+Denise%3BCrouse%2C+Nancy+S%3BSciuto%2C+Linda+C%3BCooley-Zgela%2C+Theresa%3BCamphausen%2C+Kevin%3BColeman%2C+C+Norman%3BSingh%2C+Anurag+K&rft.aulast=Simone&rft.aufirst=Nicole&rft.date=2008-01-01&rft.volume=70&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-07 N1 - Date created - 2007-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Radiat Oncol Biol Phys. 2005 Jun 1;62(2):486-93 [15890591] Radiat Res. 1995 Jul;143(1):107-10 [7597137] JAMA. 2005 Sep 14;294(10):1233-9 [16160131] Int J Impot Res. 2006 Jan-Feb;18(1):69-76 [16094413] Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1008-13 [16730138] Strahlenther Onkol. 1999 Nov;175 Suppl 4:27-9 [10584137] Radiother Oncol. 2000 Jan;54(1):11-9 [10719695] J Clin Oncol. 2000 Jun;18(11):2226-33 [10829042] Int J Radiat Oncol Biol Phys. 1978 Jul-Aug;4(7-8):643-7 [213406] Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):735-42 [14967428] Urology. 2000 Dec 20;56(6):899-905 [11113727] Radiat Res. 1978 Oct;76(1):172-9 [216048] Int J Radiat Oncol Biol Phys. 1983 Apr;9(4):507-13 [6303992] Radiobiol Radiother (Berl). 1983;24(3):357-64 [6314424] Int J Radiat Oncol Biol Phys. 2003 Jun 1;56(2):454-61 [12738320] Int J Radiat Oncol Biol Phys. 2003 Jul 15;56(4):1154-60 [12829154] CA Cancer J Clin. 2001 Jan-Feb;51(1):15-36 [11577478] Int J Radiat Oncol Biol Phys. 2001 Nov 15;51(4):988-93 [11704322] Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1097-105 [12128107] Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1160-4 [12128116] Semin Oncol. 2002 Dec;29(6 Suppl 19):57-60 [12577246] Gastroenterology. 1986 Sep;91(3):644-50 [3015711] Int J Radiat Oncol Biol Phys. 1991 Oct;21(5):1241-6 [1657841] Int J Radiat Oncol Biol Phys. 1992;22(4):799-802 [1312078] Cancer. 1992 Jun 1;69(11):2820-5 [1315211] Cancer. 1994 Oct 15;74(8):2379-84 [7922989] Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1316-21 [16029787] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk assessment to guide the prevention of cervical cancer. AN - 70164734; 18162804 AB - Advances in screening and diagnosis make it increasingly possible to prevent cervical cancer. However, if misused or poorly understood, these new tools will only increase costs and potentially harm patients without benefit. As a framework for standardized care that maximizes patient safety and well-being, we propose that a risk model be adopted to guide clinical management now and in the future. The model would use thresholds of increasing risk for cervical precancer and treatable cancer to guide clinical decision making for screening intensity, diagnostic evaluation, or treatment. Experts would decide on these risk thresholds and stratum based on the patient risk to benefit, independent of current (e.g., cytology, carcinogenic human papillomavirus testing, and colposcopy) and future methods of measuring risk. A risk management model for cervical cancer prevention, based on appropriate clinical actions that correspond to risk stratum, can result in better allocation of resources to and increased safety for women at the greatest risk and increased well-being for women at the lowest risk. JF - Journal of lower genital tract disease AU - Castle, Philip E AU - Sideri, Mario AU - Jeronimo, Jose AU - Solomon, Diane AU - Schiffman, Mark AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 1 EP - 7 VL - 12 IS - 1 SN - 1089-2591, 1089-2591 KW - Index Medicus KW - Risk Factors KW - Papillomaviridae -- isolation & purification KW - Humans KW - Vaginal Smears KW - Female KW - Colposcopy KW - Risk Assessment KW - Neoplasms, Squamous Cell -- prevention & control KW - Uterine Cervical Neoplasms -- prevention & control KW - Papillomavirus Infections -- diagnosis KW - Cervical Intraepithelial Neoplasia -- surgery KW - Uterine Cervical Neoplasms -- diagnosis KW - Algorithms KW - Neoplasms, Squamous Cell -- diagnosis KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Uterine Cervical Dysplasia -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70164734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lower+genital+tract+disease&rft.atitle=Risk+assessment+to+guide+the+prevention+of+cervical+cancer.&rft.au=Castle%2C+Philip+E%3BSideri%2C+Mario%3BJeronimo%2C+Jose%3BSolomon%2C+Diane%3BSchiffman%2C+Mark&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-01-01&rft.volume=12&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+lower+genital+tract+disease&rft.issn=10892591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-27 N1 - Date created - 2007-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Conservation of the pro-apoptotic nuclease activity of endonuclease G in unicellular trypanosomatid parasites. AN - 70156521; 18073240 AB - Endonuclease G is a mitochondrial protein implicated in DNA fragmentation during apoptosis in cell types ranging from fungi to mammals. Features of programmed cell death have been reported in a number of single-celled organisms, including the human trypanosomatid parasites Leishmania and Trypanosoma. However, the protozoan cell death pathways and the effector molecules involved in such processes remain to be identified. In this report, we describe the pro-apoptotic function of endonuclease G in trypanosomatid parasites. Similar to metazoans, trypanosome endoG showed intrinsic nuclease activity, is localized in mitochondria and is released from this organelle when cell death is triggered. Overexpression of endoG strongly promoted apoptotic cell death under oxidant or differentiation-related stress in Leishmania and, conversely, loss of endoG expression conferred robust resistance to oxidant-induced cell death in T. brucei. These data demonstrate the conservation of the pro-apoptotic endonuclease activity of endoG in these evolutionarily ancient eukaryotic organisms. Furthermore, nuclear DNA degradation by endoG upon release from mitochondria might represent a caspase-independent cell death mechanism in trypanosomatid parasites as genes encoding caspase-like proteins have not been identified in their genomes. JF - Journal of cell science AU - Gannavaram, Sreenivas AU - Vedvyas, Chetan AU - Debrabant, Alain AD - Laboratory of Bacterial, Parasitic and Unconventional Agents, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda MD 20892, USA. Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 99 EP - 109 VL - 121 SN - 0021-9533, 0021-9533 KW - Oxidants KW - 0 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Endodeoxyribonucleases KW - EC 3.1.- KW - endonuclease G KW - EC 3.1.21.- KW - Index Medicus KW - Leishmania donovani -- enzymology KW - Animals KW - Trypanosoma brucei brucei -- growth & development KW - Leishmania donovani -- growth & development KW - Humans KW - Mitochondria -- enzymology KW - Macrophages -- parasitology KW - Amino Acid Sequence KW - Leishmania donovani -- genetics KW - Genome, Protozoan KW - Hydrogen Peroxide -- toxicity KW - In Situ Nick-End Labeling KW - Sequence Alignment KW - Trypanosoma brucei brucei -- enzymology KW - Oxidants -- toxicity KW - Molecular Sequence Data KW - RNA Interference KW - Fluorescent Antibody Technique KW - Trypanosomatina -- enzymology KW - Apoptosis -- genetics KW - Endodeoxyribonucleases -- chemistry KW - Endodeoxyribonucleases -- isolation & purification KW - Trypanosomatina -- pathogenicity KW - Endodeoxyribonucleases -- genetics KW - Endodeoxyribonucleases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70156521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cell+science&rft.atitle=Conservation+of+the+pro-apoptotic+nuclease+activity+of+endonuclease+G+in+unicellular+trypanosomatid+parasites.&rft.au=Gannavaram%2C+Sreenivas%3BVedvyas%2C+Chetan%3BDebrabant%2C+Alain&rft.aulast=Gannavaram&rft.aufirst=Sreenivas&rft.date=2008-01-01&rft.volume=121&rft.issue=&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+cell+science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-05 N1 - Date created - 2007-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concentration-QT relationships play a key role in the evaluation of proarrhythmic risk during regulatory review. AN - 70155875; 18094216 AB - The criterion for assessing whether a drug prolongs QT as described in the International Conference on Harmonization topic E14 guideline does not explicitly account for individual drug concentrations. The authors' experience with reviewing QT studies indicates that understanding the relationship, if any, between individual drug concentration and QT change provides important additional information to support regulatory decision making. Therefore, regulatory reviews of "thorough QT" studies routinely include a characterization of the concentration-QT relationship. The authors provide examples to illustrate how the concentration-QT relationship has been used to plan and interpret the thorough QT study, to evaluate QT risk for drugs that have no thorough QT studies, to assess QT risk in subpopulations, to make dose adjustments, and to write informative drug labels. JF - Journal of clinical pharmacology AU - Garnett, Christine E AU - Beasley, Nhi AU - Bhattaram, V Atul AU - Jadhav, Pravin R AU - Madabushi, Rajanikanth AU - Stockbridge, Norman AU - Tornøe, Christoffer W AU - Wang, Yaning AU - Zhu, Hao AU - Gobburu, Jogarao V AD - Office of Clinical Pharmacology, Center of Drug Evaluation and Reseach, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20903-0002, USA. christine.garnett@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 13 EP - 18 VL - 48 IS - 1 SN - 0091-2700, 0091-2700 KW - Drugs, Investigational KW - 0 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Risk Factors KW - Humans KW - Clinical Trials as Topic KW - Guidelines as Topic KW - Risk Assessment -- methods KW - Arrhythmias, Cardiac -- diagnosis KW - Arrhythmias, Cardiac -- chemically induced KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- diagnosis KW - Drugs, Investigational -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70155875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Concentration-QT+relationships+play+a+key+role+in+the+evaluation+of+proarrhythmic+risk+during+regulatory+review.&rft.au=Garnett%2C+Christine+E%3BBeasley%2C+Nhi%3BBhattaram%2C+V+Atul%3BJadhav%2C+Pravin+R%3BMadabushi%2C+Rajanikanth%3BStockbridge%2C+Norman%3BTorn%C3%B8e%2C+Christoffer+W%3BWang%2C+Yaning%3BZhu%2C+Hao%3BGobburu%2C+Jogarao+V&rft.aulast=Garnett&rft.aufirst=Christine&rft.date=2008-01-01&rft.volume=48&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-18 N1 - Date created - 2007-12-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Pharmacol. 2008 Jan;48(1):9-12 [18094215] J Clin Pharmacol. 2008 Jan;48(1):6-8 [18094214] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Work-related asthma in the educational services industry: California, Massachusetts, Michigan, and New Jersey, 1993-2000. AN - 70152531; 18033692 AB - To characterize work-related asthma (WRA) cases working in the educational services industry identified by state-based occupational disease surveillance systems. We examined 2,995 WRA cases reported from 1993 to 2000 to four states: California, Massachusetts, Michigan, and New Jersey. A total of 265 (9%) WRA cases were employed in the educational services industry; 69% of cases were classified as new-onset asthma and 31% as work-aggravated asthma. New-onset asthma cases were further classified as occupational asthma (61%) or as reactive airways dysfunction syndrome (8%). The most frequently reported occupation was teachers and teachers' aides (54%). The most frequently reported agents were indoor air pollutants (28%), unspecified mold (16%), dusts (14%), and cleaning products (7%). Asthma within the educational services industry is an occupational health problem. The health of school employees should also be considered when initiatives addressing asthma among schoolchildren are instituted. The identification, elimination, and/or control of respiratory hazards are important factors for the protection of staff and students alike. 2007 Wiley-Liss, Inc JF - American journal of industrial medicine AU - Mazurek, Jacek M AU - Filios, Margaret AU - Willis, Ruth AU - Rosenman, Kenneth D AU - Reilly, Mary Jo AU - McGreevy, Katharine AU - Schill, Donald P AU - Valiante, David AU - Pechter, Elise AU - Davis, Letitia AU - Flattery, Jennifer AU - Harrison, Robert AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. acq8@cdc.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 47 EP - 59 VL - 51 IS - 1 SN - 0271-3586, 0271-3586 KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Workplace KW - Adolescent KW - United States -- epidemiology KW - Schools -- statistics & numerical data KW - Male KW - Female KW - Prevalence KW - Asthma -- epidemiology KW - Faculty -- statistics & numerical data KW - Air Pollutants, Occupational -- adverse effects KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70152531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Work-related+asthma+in+the+educational+services+industry%3A+California%2C+Massachusetts%2C+Michigan%2C+and+New+Jersey%2C+1993-2000.&rft.au=Mazurek%2C+Jacek+M%3BFilios%2C+Margaret%3BWillis%2C+Ruth%3BRosenman%2C+Kenneth+D%3BReilly%2C+Mary+Jo%3BMcGreevy%2C+Katharine%3BSchill%2C+Donald+P%3BValiante%2C+David%3BPechter%2C+Elise%3BDavis%2C+Letitia%3BFlattery%2C+Jennifer%3BHarrison%2C+Robert&rft.aulast=Mazurek&rft.aufirst=Jacek&rft.date=2008-01-01&rft.volume=51&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2007-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay. AN - 70147226; 17707568 AB - The Brazilian mushroom Agaricus blazei Murill has antimutagenic, antioxidant, immunostimulatory and antitumorigenic activities, and is increasingly consumed as a health food worldwide. We undertook the present study to evaluate the chronic toxicity and oncogenicity of A. blazei Murill in F344 rats. To establish a no-observed-adverse-effect level (NOAEL), four treatment groups of 100 rats each (50 males and 50 females) were fed a powder diet containing lyophilized A. blazei aqueous extract at 0, 6250, 12,500, and 25,000 ppm for up to 2 years. During this period, there was no remarkable change in mean body weight, body weight gain, hematologic or serum chemistry parameters, or absolute or relative organ weights in control or treatment groups. Mortality in male treatment groups (26%, 16%, and 30%), however, was significantly lower than in controls (48%). Histopathological studies showed no increased incidence of tumors in any treatment group, and total tumor incidence across all groups was comparable to historical data. In conclusion, an A. blazei Murill lyophilized powder diet even at 25,000 ppm (1176 mg/kgb x w x /day for male rats and 1518 mg/kgb.w./day for female rats) resulted in no remarkable carcinogenic effects in F344 rats over a 2-year period. Therefore, the dietary NOAEL is 25,000 ppm. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Lee, I P AU - Kang, B H AU - Roh, J K AU - Kim, J R AD - Laboratory of Molecular Toxicology, Toxicological Research Center, Korea Food and Drug Administration, 5 Nokbun-Dong, Unpyong-Ku, Seoul 122-704, Republic of Korea. iplee0823@aol.com Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 87 EP - 95 VL - 46 IS - 1 SN - 0278-6915, 0278-6915 KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Sex Characteristics KW - Freeze Drying KW - Eye Diseases -- chemically induced KW - Organ Size KW - Blood Cell Count KW - Rats KW - Eating KW - Rats, Inbred F344 KW - No-Observed-Adverse-Effect Level KW - Neoplasms -- pathology KW - Body Weight -- drug effects KW - Neoplasms -- chemically induced KW - Carcinogenicity Tests KW - Eye Diseases -- pathology KW - Diet KW - Female KW - Male KW - Agaricales -- chemistry KW - Carcinogens -- chemistry KW - Carcinogens -- toxicity KW - Agaricus -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70147226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Lack+of+carcinogenicity+of+lyophilized+Agaricus+blazei+Murill+in+a+F344+rat+two+year+bioassay.&rft.au=Lee%2C+I+P%3BKang%2C+B+H%3BRoh%2C+J+K%3BKim%2C+J+R&rft.aulast=Lee&rft.aufirst=I&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. AN - 70090625; 17934191 AB - Sensitive biomarkers are needed to detect kidney injury at the earliest stages. The objective of this study was to determine whether the appearance of kidney injury molecule-1 (Kim-1) protein ectodomain in urine and kidney injury molecule-1/hepatitis A viral cellular receptor-1 (Kim-1/Havcr1) gene expression in kidney tissue may be more predictive of renal injury after exposure to nephrotoxicants when compared to traditionally used biomarkers. Male Sprague-Dawley rats were injected with a range of doses of gentamicin, mercury (Hg; HgCl2), or chromium (Cr; K2Cr2O7). The results showed that increases in urinary Kim-1 and kidney Kim-1/Havcr1 gene expression paralleled the degree of severity of renal histopathology and were detected at lower doses of nephrotoxicants when compared to blood urea nitrogen (BUN), serum creatinine, and urinary N-acetyl-beta-D-glucosaminidase (NAG). In a time course study, urinary Kim-1 was elevated within 24 h after exposure to gentamicin (100 mg/kg), Hg (0.25 mg/kg), or Cr (5 mg/kg) and remained elevated through 72 h. NAG responses were nephrotoxicant dependent with elevations occurring early (gentamicin), late (Cr), or no change (Hg). At 72 h, after treatment with any of the three nephrotoxicants, there was increased Kim-1 immunoreactivity and necrosis involving approximately 50% of the proximal tubules; however, only urinary Kim-1 was significantly increased, while BUN, serum creatinine, and NAG were not different from controls. In rats treated with the hepatotoxicant galactosamine (1.1 mg/kg), serum alanine aminotransferase was increased, but no increase in urinary Kim-1 was observed. Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury following exposure to nephrotoxic chemicals and drugs. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Zhou, Yuzhao AU - Vaidya, Vishal S AU - Brown, Ronald P AU - Zhang, Jun AU - Rosenzweig, Barry A AU - Thompson, Karol L AU - Miller, Terry J AU - Bonventre, Joseph V AU - Goering, Peter L AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, White Oak Life Sciences Laboratory, Silver Spring, MD 20993, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 159 EP - 170 VL - 101 IS - 1 SN - 1096-6080, 1096-6080 KW - Biomarkers KW - 0 KW - Cell Adhesion Molecules KW - Gentamicins KW - Havcr1protein, rat KW - Membrane Proteins KW - Protein Synthesis Inhibitors KW - Chromium KW - 0R0008Q3JB KW - RNA KW - 63231-63-0 KW - Galactosamine KW - 7535-00-4 KW - Mercury KW - FXS1BY2PGL KW - Acetylglucosamine KW - V956696549 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Kidney Function Tests KW - Chemical and Drug Induced Liver Injury -- urine KW - Dose-Response Relationship, Drug KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA -- biosynthesis KW - Rats KW - Acetylglucosamine -- urine KW - Rats, Sprague-Dawley KW - Galactosamine -- toxicity KW - RNA -- isolation & purification KW - Immunohistochemistry KW - Male KW - Kidney Diseases -- pathology KW - Kidney -- pathology KW - Membrane Proteins -- metabolism KW - Kidney Diseases -- urine KW - Cell Adhesion Molecules -- analysis KW - Membrane Proteins -- analysis KW - Chromium -- toxicity KW - Kidney -- chemistry KW - Cell Adhesion Molecules -- urine KW - Gentamicins -- toxicity KW - Protein Synthesis Inhibitors -- toxicity KW - Membrane Proteins -- urine KW - Cell Adhesion Molecules -- metabolism KW - Mercury -- toxicity KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70090625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Comparison+of+kidney+injury+molecule-1+and+other+nephrotoxicity+biomarkers+in+urine+and+kidney+following+acute+exposure+to+gentamicin%2C+mercury%2C+and+chromium.&rft.au=Zhou%2C+Yuzhao%3BVaidya%2C+Vishal+S%3BBrown%2C+Ronald+P%3BZhang%2C+Jun%3BRosenzweig%2C+Barry+A%3BThompson%2C+Karol+L%3BMiller%2C+Terry+J%3BBonventre%2C+Joseph+V%3BGoering%2C+Peter+L&rft.aulast=Zhou&rft.aufirst=Yuzhao&rft.date=2008-01-01&rft.volume=101&rft.issue=1&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-20 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Acta Vitaminol Enzymol. 1984;6(2):103-7 [6496253] Am J Physiol Renal Physiol. 2007 Jan;292(1):F313-20 [16896183] Environ Health Perspect. 1991 May;92:71-4 [1935854] Pharmacol Toxicol. 1991 May;68(5):317-21 [1946176] Gen Pharmacol. 1995 Nov;26(7):1477-87 [8690234] EMBO J. 1996 Aug 15;15(16):4282-96 [8861957] Drug Saf. 1997 Mar;16(3):205-31 [9098657] J Biol Chem. 1998 Feb 13;273(7):4135-42 [9461608] Toxicol Pathol. 1998 Jan-Feb;26(1):92-103 [9502391] J Virol. 1998 Aug;72(8):6621-8 [9658108] J Am Soc Nephrol. 2005 Apr;16(4):1126-34 [15744000] BMC Nephrol. 2005;6:4 [15854231] J Am Soc Nephrol. 2005 Nov;16(11):3365-70 [16177006] Am J Physiol Renal Physiol. 2006 Feb;290(2):F517-29 [16174863] J Am Soc Nephrol. 2007 Mar;18(3):904-12 [17267747] Am J Surg Pathol. 2007 Mar;31(3):371-81 [17325478] Ren Fail. 2002 Nov;24(6):687-90 [12472192] Free Radic Biol Med. 2003 Jun 1;34(11):1390-8 [12757849] Toxicol Sci. 2003 Sep;75(1):208-22 [12832660] Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63 [14600030] Am J Med. 1968 May;44(5):664-705 [5646427] Toxicol Appl Pharmacol. 1980 Jul;54(3):443-53 [6446781] J Toxicol Environ Health. 1982 Jan;9(1):119-26 [6460873] Biochem Pharmacol. 1982 Oct 1;31(19):3093-100 [6216890] Pharmacol Rev. 2000 Mar;52(1):113-43 [10699157] Therapie. 2000 Jan-Feb;55(1):91-6 [10860006] J Environ Sci Health B. 2001 Sep;36(5):687-97 [11599730] Kidney Int. 2002 Jul;62(1):237-44 [12081583] Cleve Clin J Med. 2002 Jul;69(7):569-74 [12109642] J Biol Chem. 2002 Oct 18;277(42):39739-48 [12138159] Kidney Int. 1991 Apr;39(4):639-46 [1711136] Am J Physiol Renal Physiol. 2006 Aug;291(2):F456-64 [16467126] Am J Physiol Renal Physiol. 2007 Jan;292(1):F131-9 [16835406] Am J Physiol Renal Physiol. 2002 Dec;283(6):F1326-36 [12388382] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessing total fungal concentrations on commercial passenger aircraft using mixed-effects modeling. AN - 70089826; 18041644 AB - The primary objective of this study was to compare airborne fungal concentrations onboard commercial passenger aircraft at various in-flight times with concentrations measured inside and outside airport terminals. A secondary objective was to investigate the use of mixed-effects modeling of repeat measures from multiple sampling intervals and locations. Sequential triplicate culturable and total spore samples were collected on wide-body commercial passenger aircraft (n = 12) in the front and rear of coach class during six sampling intervals: boarding, midclimb, early cruise, midcruise, late cruise, and deplaning. Comparison samples were collected inside and outside airport terminals at the origin and destination cities. The MIXED procedure in SAS was used to model the mean and the covariance matrix of the natural log transformed fungal concentrations. Five covariance structures were tested to determine the appropriate models for analysis. Fixed effects considered included the sampling interval and, for samples obtained onboard the aircraft, location (front/rear of coach section), occupancy rate, and carbon dioxide concentrations. Overall, both total culturable and total spore fungal concentrations were low while the aircraft were in flight. No statistical difference was observed between measurements made in the front and rear sections of the coach cabin for either culturable or total spore concentrations. Both culturable and total spore concentrations were significantly higher outside the airport terminal compared with inside the airport terminal (p-value < 0.0001) and inside the aircraft (p-value < 0.0001). On the aircraft, the majority of total fungal exposure occurred during the boarding and deplaning processes, when the aircraft utilized ancillary ventilation and passenger activity was at its peak. JF - Journal of occupational and environmental hygiene AU - McKernan, Lauralynn Taylor AU - Hein, Misty J AU - Wallingford, Kenneth M AU - Burge, Harriet AU - Herrick, Robert AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio 45226, USA. lmckernan@cdc.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 48 EP - 58 VL - 5 IS - 1 SN - 1545-9624, 1545-9624 KW - Air Pollutants KW - 0 KW - Index Medicus KW - Air Pollution, Indoor -- analysis KW - Colony Count, Microbial KW - Models, Statistical KW - Environmental Monitoring -- statistics & numerical data KW - Aircraft KW - Air Pollutants -- isolation & purification KW - Fungi -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70089826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Assessing+total+fungal+concentrations+on+commercial+passenger+aircraft+using+mixed-effects+modeling.&rft.au=McKernan%2C+Lauralynn+Taylor%3BHein%2C+Misty+J%3BWallingford%2C+Kenneth+M%3BBurge%2C+Harriet%3BHerrick%2C+Robert&rft.aulast=McKernan&rft.aufirst=Lauralynn&rft.date=2008-01-01&rft.volume=5&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence of asthma among youth on Hispanic-operated farms in the United States-2000. AN - 69877518; 19064420 AB - The objective of this study was to estimate prevalence of asthma and asthma attacks among youth (0-19 years old) working and/or living on Hispanic-operated farms. The 2000 U.S. Minority Farm Operator Childhood Agricultural Injury Survey (M-CAIS) data were used to calculate prevalence of asthma, asthma attacks and serious asthma attacks among youth (0 to 19 years) living on Hispanic-operated farms. Age-specific asthma prevalence rates with corresponding 95% confidence intervals (CIs) were calculated for working and nonworking youth. In 2000, an estimated 17,573 youth lived on Hispanic-operated farms; 7.4% had asthma ever diagnosed, 8.1% had an asthma attack while at work in the last year, and 1.4% had a serious asthma attack. Asthma prevalence was highest among youth aged 16-19 (9.1%), males (8.6%), and those driving tractors (9.7%). Serious asthma attacks that required an emergency room visit or hospitalization in the last year were most prevalent among youth aged 0-9 years (1.8%), males (1.7%), and those riding horses (1.7%). Compared with nonworking youth, prevalence of asthma (8.9% versus 6.1%; p p > .05) was higher among working youth. Prevalence of asthma attacks in the last year while at work was also significantly higher among males than females (8.6% versus 6.0%; p p < .05). These findings contribute to the limited information on asthma among youth working on Hispanic-operated farms, and indicate the need for asthma prevention programs on farms and intervention studies targeting farming youth populations. JF - Journal of agromedicine AU - Syamlal, Girija AU - Mazurek, Jacek M AD - Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morganton, West Virginia, USA. gos2@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 155 EP - 164 VL - 13 IS - 3 SN - 1059-924X, 1059-924X KW - Index Medicus KW - Occupational Exposure KW - Young Adult KW - Occupational Health KW - Age Factors KW - Sex Factors KW - Humans KW - Infant, Newborn KW - Child KW - Child, Preschool KW - Infant KW - Off-Road Motor Vehicles KW - Risk Factors KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Prevalence KW - Agriculture KW - Asthma -- epidemiology KW - Hispanic Americans -- statistics & numerical data KW - Asthma -- ethnology KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- ethnology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69877518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Prevalence+of+asthma+among+youth+on+Hispanic-operated+farms+in+the+United+States-2000.&rft.au=Syamlal%2C+Girija%3BMazurek%2C+Jacek+M&rft.aulast=Syamlal&rft.aufirst=Girija&rft.date=2008-01-01&rft.volume=13&rft.issue=3&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F10599240802397875 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-06 N1 - Date created - 2008-12-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10599240802397875 ER - TY - JOUR T1 - Safety alert for fentanyl buccal tablets. AN - 69874373; 19062355 AB - On September 13, 2007, the United States Food and Drug Administration posted a safety alert for fentanyl buccal tablets (Fentora). The announcement and hyperlinks to the Dear Doctor and Dear Healthcare Professional Letters that were distributed by the sponsor are presented. JF - Journal of pain & palliative care pharmacotherapy AU - U.S. Food and Drug Administration AD - U.S. Food and Drug Administration Y1 - 2008 PY - 2008 DA - 2008 SP - 47 VL - 22 IS - 1 KW - Analgesics, Opioid KW - 0 KW - Tablets KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - United States KW - Pain -- etiology KW - Pain -- drug therapy KW - United States Food and Drug Administration KW - Neoplasms -- complications KW - Humans KW - Administration, Buccal KW - Palliative Care KW - Respiratory Insufficiency -- chemically induced KW - Adverse Drug Reaction Reporting Systems KW - Fentanyl -- adverse effects KW - Analgesics, Opioid -- therapeutic use KW - Fentanyl -- therapeutic use KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage KW - Fentanyl -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69874373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.atitle=Safety+alert+for+fentanyl+buccal+tablets.&rft.au=U.S.+Food+and+Drug+Administration&rft.aulast=U.S.+Food+and+Drug+Administration&rft.aufirst=&rft.date=2008-01-01&rft.volume=22&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.issn=1536-0539&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Marijuana neurobiology and treatment. AN - 69849778; 19042204 AB - Marijuana is the number one illicit drug of abuse worldwide and a major public health problem, especially in the younger population. The objective of this article is to update and review the state of the science and treatments available for marijuana dependence based on a pre-meeting workshop that was presented at ISAM 2006. At the workshop, several papers were presented addressing the neurobiology and pharmacology of marijuana and treatment approaches, both psychotherapy and medications, for marijuana withdrawal. Medicolegal and ethical issues concerning marijuana medical use were also discussed. Concise summaries of these presentations are incorporated in this article, which is meant to be an updated review of the state of the science. Major advances have been made in understanding the underpinning of marijuana dependence and the role of the CNS cannabinoid system, which is a major area for targeting medications to treat marijuana withdrawal and dependence, as well as other addictions. Behavioral therapies are efficacious for facilitating abstinence from marijuana. Nefazadone, Marinol, and buspirone are showing early positive signals for efficacy in ameliorating marijuana withdrawal symptoms. Effective psychotherapeutic approaches are available and promising medications studies need to be confirmed in outpatient trials. The next few years looking promising for translational research efforts to make treatment widely accessible to patients with marijuana dependence. JF - Substance abuse AU - Elkashef, Ahmed AU - Vocci, Frank AU - Huestis, Marilyn AU - Haney, Margaret AU - Budney, Alan AU - Gruber, Amanda AU - el-Guebaly, Nady AD - Clinical Medical Branch, Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. ae8a@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 17 EP - 29 VL - 29 IS - 3 SN - 0889-7077, 0889-7077 KW - Narcotic Antagonists KW - 0 KW - Triazoles KW - nefazodone KW - 59H4FCV1TF KW - Dronabinol KW - 7J8897W37S KW - Buspirone KW - TK65WKS8HL KW - Index Medicus KW - Cognitive Therapy KW - Humans KW - Social Facilitation KW - Dronabinol -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Buspirone -- therapeutic use KW - Marijuana Abuse -- rehabilitation KW - Brain -- drug effects KW - Marijuana Abuse -- therapy KW - Triazoles -- therapeutic use KW - Cannabis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69849778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Marijuana+neurobiology+and+treatment.&rft.au=Elkashef%2C+Ahmed%3BVocci%2C+Frank%3BHuestis%2C+Marilyn%3BHaney%2C+Margaret%3BBudney%2C+Alan%3BGruber%2C+Amanda%3Bel-Guebaly%2C+Nady&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2008-01-01&rft.volume=29&rft.issue=3&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/10.1080%2F08897070802218166 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Consult Clin Psychol. 2004 Jun;72(3):455-66 [15279529] Am J Addict. 2004 Jan-Feb;13(1):21-32 [14766435] J Subst Abuse Treat. 2004 Oct;27(3):195-6 [15501372] J Subst Abuse Treat. 2004 Oct;27(3):197-213 [15501373] Am J Psychiatry. 2004 Nov;161(11):1967-77 [15514394] Psychopharmacology (Berl). 1981;74(3):208-12 [6267648] J Pharmacol Exp Ther. 1986 Nov;239(2):311-9 [3021952] Int J Addict. 1987 Jul;22(7):639-51 [3497886] Nature. 1990 Aug 9;346(6284):561-4 [2165569] J Anal Toxicol. 1992 Sep-Oct;16(5):302-6 [1338218] J Consult Clin Psychol. 1993 Dec;61(6):1100-4 [8113490] Arch Gen Psychiatry. 1994 Jul;51(7):568-76 [8031230] J Consult Clin Psychol. 1994 Feb;62(1):92-9 [8034835] Drug Alcohol Depend. 1995 Nov;40(1):9-15 [8746919] Psychopharmacology (Berl). 1999 Feb;141(4):395-404 [10090647] Addict Behav. 1999 Jan-Feb;24(1):111-4 [10189977] Psychopharmacology (Berl). 1999 Apr;143(3):302-8 [10353434] J Am Acad Child Adolesc Psychiatry. 2005 Jun;44(6):513-21 [15908833] Am Heart J. 2006 Mar;151(3):754.e1-754.e5 [16504646] J Consult Clin Psychol. 2006 Feb;74(1):42-54 [16551142] J Consult Clin Psychol. 2006 Apr;74(2):307-16 [16649875] Am J Addict. 2006 Sep-Oct;15(5):404 [16966201] Addict Behav. 2007 Jun;32(6):1220-36 [16996224] Neuropsychopharmacology. 2007 Jun;32(6):1391-403 [17091128] Drug Alcohol Depend. 2007 Oct 8;90(2-3):210-23 [17481828] Drug Alcohol Depend. 2005 Jul;79(1):11-22 [15943940] Curr Psychiatry Rep. 2005 Oct;7(5):360-6 [16216154] Addiction. 1999 Sep;94(9):1311-22 [10615717] Ann Emerg Med. 2000 Apr;35(4):398-9 [10736129] Nat Neurosci. 2000 Nov;3(11):1073-4 [11036260] J Consult Clin Psychol. 2000 Oct;68(5):898-908 [11068976] J Consult Clin Psychol. 2000 Dec;68(6):1051-61 [11142539] Arch Gen Psychiatry. 2001 Apr;58(4):322-8 [11296091] Psychopharmacology (Berl). 2001 May;155(2):171-9 [11401006] J Subst Abuse Treat. 2001 Sep;21(2):55-64; discussion 65-6 [11551733] Arch Gen Psychiatry. 2001 Oct;58(10):909-15 [11576028] Arch Gen Psychiatry. 2001 Oct;58(10):917-24 [11576029] Nat Med. 2001 Oct;7(10):1151-4 [11590440] J Consult Clin Psychol. 2001 Oct;69(5):802-13 [11680557] Am J Drug Alcohol Abuse. 2001 Nov;27(4):651-88 [11727882] J Neurosci. 2001 Dec 15;21(24):9867-76 [11739594] Neuropsychopharmacology. 2002 Apr;26(4):479-88 [11927172] Drug Alcohol Depend. 2002 Aug 1;67(3):301-9 [12127201] Psychopharmacology (Berl). 2002 Dec;164(4):407-15 [12457271] Psychopharmacology (Berl). 2003 Jan;165(2):157-65 [12439626] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1393-8 [12538878] J Subst Abuse Treat. 2003 Jun;24(4):369-76 [12867212] J Int Neuropsychol Soc. 2003 Jul;9(5):679-89 [12901774] J Abnorm Psychol. 2003 Aug;112(3):393-402 [12943018] J Subst Abuse Treat. 2003 Sep;25(2):85-9 [14629990] Psychol Med. 2003 Nov;33(8):1415-22 [14672250] Neuropsychopharmacology. 2004 Jan;29(1):158-70 [14560320] Prog Neuropsychopharmacol Biol Psychiatry. 2004 Aug;28(5):849-63 [15363608] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08897070802218166 ER - TY - JOUR T1 - Pharmacotherapy of methamphetamine addiction: an update. AN - 69839698; 19042205 AB - Methamphetamine dependence is a serious public health problem worldwide for which there are no approved pharmacological treatments. Psychotherapy is still the mainstay of treatment; however, relapse rates are high. The search for effective pharmacological treatment has intensified in the last decade. This review will highlight progress in pharmacological interventions to treat methamphetamine dependence as well as explore new pharmacological targets. Published data from clinical trials for stimulant addiction were searched using PubMed and summarized, as well as highlights from a recent symposium on methamphetamine pharmacotherapy presented at the ISAM 2006 meeting, including interim analysis data from an ongoing D-amphetamine study in Australia. Early pilot data are encouraging for administering D-amphetamine and methylphenidate as treatment for heavy amphetamine users. Abilify at 15 mg/day dose increased amphetamine use in an outpatient pilot study. Sertraline, ondansetron, baclofen, tyrosine, and imipramine were ineffective in proof-of-concept studies. Development of pharmacotherapy for methamphetamine dependence is still in an early stage. Data suggesting D-amphetamine and methylphenidate as effective pharmacotherapy for methamphetamine addiction will need to be confirmed by larger trials. Preclinical data suggest that use of GVG, CB1 antagonist, and lobeline are also promising therapeutic strategies. JF - Substance abuse AU - Elkashef, Ahmed AU - Vocci, Frank AU - Hanson, Glen AU - White, Jason AU - Wickes, Wendy AU - Tiihonen, Jari AD - Clinical Medical Branch, Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. ae8a@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 31 EP - 49 VL - 29 IS - 3 SN - 0889-7077, 0889-7077 KW - Antipsychotic Agents KW - 0 KW - Central Nervous System Stimulants KW - Narcotic Antagonists KW - Nicotinic Agonists KW - Piperazines KW - Quinolones KW - Bupropion KW - 01ZG3TPX31 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Methamphetamine KW - 44RAL3456C KW - Aripiprazole KW - 82VFR53I78 KW - Lobeline KW - D0P25S3P81 KW - Dextroamphetamine KW - TZ47U051FI KW - Index Medicus KW - Dextroamphetamine -- therapeutic use KW - Nicotinic Agonists -- therapeutic use KW - Quinolones -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Bupropion -- therapeutic use KW - Piperazines -- therapeutic use KW - Humans KW - Antipsychotic Agents -- therapeutic use KW - Methylphenidate -- therapeutic use KW - Lobeline -- therapeutic use KW - Recurrence KW - Prevalence KW - Drug Therapy -- methods KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Pharmacotherapy+of+methamphetamine+addiction%3A+an+update.&rft.au=Elkashef%2C+Ahmed%3BVocci%2C+Frank%3BHanson%2C+Glen%3BWhite%2C+Jason%3BWickes%2C+Wendy%3BTiihonen%2C+Jari&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2008-01-01&rft.volume=29&rft.issue=3&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/10.1080%2F08897070802218554 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Synapse. 2001 Jul;41(1):22-8 [11354010] Pharmacol Rev. 2001 Jun;53(2):209-43 [11356984] J Pharmacol Exp Ther. 2001 Jul;298(1):172-9 [11408539] Nat Neurosci. 2001 Sep;4(9):873-4 [11528416] Addiction. 2001 Sep;96(9):1289-96 [11672493] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] J Neurosci. 2000 Aug 1;20(15):RC89 [10899176] Cochrane Database Syst Rev. 2002;(2):CD002025 [12076434] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11452-7 [12154229] J Neurochem. 2002 Sep;82(5):1171-8 [12358764] J Neurosci. 2002 Nov 1;22(21):9595-603 [12417684] Neuropsychopharmacology. 2003 Feb;28(2):329-38 [12589386] Synapse. 2003 Jun 1;48(3):154-6 [12645041] Mol Psychiatry. 2003 Apr;8(4):373-82 [12740594] Physiol Behav. 2003 Jun;79(1):121-8 [12818717] Neuropsychopharmacology. 2003 Jul;28(7):1272-80 [12700694] J Neurosci Res. 2003 Oct 1;74(1):91-6 [13130510] Ann N Y Acad Sci. 2003 Nov;1003:415-8 [14684476] Am J Psychiatry. 2004 Feb;161(2):242-8 [14754772] Psychopharmacology (Berl). 2004 Mar;172(2):170-8 [14624331] Alcohol Clin Exp Res. 2004 Apr;28(4):558-65 [15100606] Trends Pharmacol Sci. 2004 May;25(5):265-72 [15120493] J Neurosci. 2004 May 19;24(20):4723-7 [15152032] Am J Addict. 2004 May-Jun;13(3):248-55 [15370944] Psychopharmacology (Berl). 2004 Oct;176(1):57-65 [15083257] Med J Aust. 1990 Sep 3;153(5):306 [2392087] Nature. 1990 Sep 13;347(6289):146-51 [1975644] NIDA Res Monogr. 1991;115:84-98 [1758486] Br J Addict. 1992 Mar;87(3):439-46 [1559042] Addiction. 1994 Jan;89(1):79-85 [8148747] Acta Psychiatr Scand. 1994 Jun;89(6):428-32 [8085475] J R Soc Health. 1994 Jun;114(3):127-31 [7932481] Eur J Pharmacol. 1995 Aug 4;281(2):R7-9 [7589197] J Pharmacol Exp Ther. 1996 Sep;278(3):1128-37 [8819495] J Neurosci. 1997 Apr 1;17(7):2605-14 [9065520] Synapse. 1997 Apr;25(4):393-8 [9097399] Mol Psychiatry. 1997 Jan;2(1):5-6 [9154208] J Subst Abuse Treat. 1996 Nov-Dec;13(6):493-7 [9219147] Neuroreport. 1997 Jul 7;8(9-10):2373-7 [9243643] Pediatrics. 1997 Oct;100(4):662-6 [9310521] J Pharmacol Exp Ther. 1997 Oct;283(1):7-15 [9336302] Drug Alcohol Depend. 1997 Nov 25;48(2):113-8 [9363410] Psychopharmacology (Berl). 1998 May;137(2):184-90 [9630005] J Neurosci. 1998 Jul 15;18(14):5529-36 [9651233] Drug Alcohol Depend. 1998 Sep 1;52(1):79-84 [9788010] Nature. 1999 Jul 22;400(6742):371-5 [10432116] Aust N Z J Psychiatry. 1999 Aug;33(4):494-502 [10483843] J Clin Psychopharmacol. 2004 Dec;24(6):665-9 [15538132] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Psychopharmacology (Berl). 2005 Mar;178(2-3):296-302 [15452681] Neuron. 2005 Mar 3;45(5):647-50 [15748840] Neuropsychopharmacology. 2005 Apr;30(4):720-30 [15562293] Int J Neuropsychopharmacol. 2005 Jun;8(2):203-13 [15850499] Synapse. 2005 Jul;57(1):17-28 [15858839] J Med Chem. 2005 Jun 2;48(11):3663-79 [15916415] Am J Hypertens. 2005 Jun;18(6):813-22 [15925741] Neuroreport. 2005 Jun 21;16(9):1013-6 [15931079] Brain Res Brain Res Rev. 2005 Jul;49(1):77-105 [15960988] Drug Discov Today. 2005 Jul 1;10(13):917-25 [15993811] Behav Pharmacol. 2005 Sep;16(5-6):275-96 [16148435] Nature. 2005 Sep 22;437(7058):556-9 [16100511] Psychopharmacology (Berl). 2005 Nov;182(3):426-35 [16163531] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19168-73 [16357203] Pharmacol Biochem Behav. 2005 Dec;82(4):704-11 [16413604] Drug Alcohol Depend. 2006 Oct 15;85(1):12-8 [16621339] Drug Alcohol Depend. 2006 Dec 1;85(3):177-84 [16740370] Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):123-30 [16978753] Am J Psychiatry. 2007 Jan;164(1):160-2 [17202560] Int J Neuropsychopharmacol. 2007 Feb;10(1):85-98 [16448579] Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):455-61 [17184890] Synapse. 2005 Feb;55(2):122-5 [15543630] Mol Pharmacol. 2005 Feb;67(2):349-55 [15548766] Ann N Y Acad Sci. 1999;897:27-45 [10676433] Addiction. 2000 Feb;95(2):229-38 [10723851] J Psychiatry Neurosci. 2000 Mar;25(2):125-36 [10740986] Neurology. 2000 Mar 28;54(6):1344-9 [10746608] Ann N Y Acad Sci. 2000;909:260-3 [10911936] Psychopharmacology (Berl). 2000 Jun;150(3):317-24 [10923760] Am J Addict. 2000 Summer;9(3):222-31 [11000918] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08897070802218554 ER - TY - JOUR T1 - Long-term consequences of drugs on the paediatric cardiovascular system. AN - 69819328; 19026026 AB - Many pharmacological and toxicological actions of drugs in children cannot be fully predicted from adult clinical experience or from standard non-clinical toxicology studies. Numerous drugs have direct or indirect pharmacological effects on the heart and are prescribed for children of all ages. Toxicity or secondary effects may be immediate or delayed for years after drug exposure has ceased. Originally, the aim of this review was to compile information on the effect of specific drugs on the post-natal development of the cardiovascular system and to examine long-term follow-up of the use of cardio-active drugs in children. The limited database of published information caused the original question to evolve into an examination of the medical literature for three areas of information: (i) whether vulnerable developmental windows have been identified that reflect the substantial functional development that the cardiovascular system undergoes after birth; (ii) what is known about pharmacological perturbation of development; and (iii) what the likelihood is of drug exposure during childhood. We examined different scenarios for exposure including random, isolated exposure, conditions historically associated with adults, primary or secondary cardiac disease, psychiatric and neurological conditions, asthma, cancer and HIV. Except for random, isolated drug exposures, each category of possible exposure contained numerous drugs known to have either primary or secondary effects on the cardiovascular system or to influence factors associated with atherosclerosis. It is likely that a significant number of children will be prescribed drugs having either direct or indirect effects upon the immature cardiovascular system. A confounding factor is the simultaneous use of over-the-counter medications and herbal or nutraceutical preparations that a patient, parent or guardian does not mention to a prescribing physician. Metabolism is also important in assessing drug effects in children. Differences in body water : body fat ratio, age-related gastrointestinal absorption, distribution, excretion, renal function and drug metabolizing capabilities make it possible for children to have a different metabolite profile for a drug compared with adults. There is little examination of drug effects on the interdependent processes of cardiac maturation and less examination of metabolite effects. It is difficult to identify delayed toxicities in children as these adverse events may take years to manifest with many patients lost to follow-up. Clearly this is an area of study where intermediate endpoints and surrogate markers would be of great benefit. Pharmacogenomics may be useful in providing markers of increased risk or susceptibility. A perspective must be kept in balancing the possibility of a problem with the very real benefits that many children experience from the use of these pharmaceuticals. JF - Drug safety AU - Hausner, Elizabeth AU - Fiszman, Monica L AU - Hanig, Joseph AU - Harlow, Patricia AU - Zornberg, Gwen AU - Sobel, Solomon AD - Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 1083 EP - 1096 VL - 31 IS - 12 SN - 0114-5916, 0114-5916 KW - Anti-Asthmatic Agents KW - 0 KW - Anti-HIV Agents KW - Anticonvulsants KW - Antineoplastic Agents KW - Glucocorticoids KW - Nonprescription Drugs KW - Prescription Drugs KW - Psychotropic Drugs KW - Index Medicus KW - Age Factors KW - Biomedical Research -- organization & administration KW - Humans KW - Anti-HIV Agents -- adverse effects KW - Anticonvulsants -- adverse effects KW - Complementary Therapies -- adverse effects KW - Child KW - Glucocorticoids -- adverse effects KW - Psychotropic Drugs -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Nonprescription Drugs -- adverse effects KW - Polypharmacy KW - Clinical Trials as Topic -- legislation & jurisprudence KW - Prescription Drugs -- adverse effects KW - Pediatrics KW - Child Development -- drug effects KW - Cardiovascular System -- drug effects KW - Prescription Drugs -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69819328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Long-term+consequences+of+drugs+on+the+paediatric+cardiovascular+system.&rft.au=Hausner%2C+Elizabeth%3BFiszman%2C+Monica+L%3BHanig%2C+Joseph%3BHarlow%2C+Patricia%3BZornberg%2C+Gwen%3BSobel%2C+Solomon&rft.aulast=Hausner&rft.aufirst=Elizabeth&rft.date=2008-01-01&rft.volume=31&rft.issue=12&rft.spage=1083&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/10.2165%2F0002018-200831120-00005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-05 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2165/0002018-200831120-00005 ER - TY - JOUR T1 - Ergonomics interventions at Badger Mining Corporation. AN - 69720219; 18954545 AB - In 2005, the National Institute for Occupational Safety and Health (NIOSH) and Badger Mining Corporation entered a partnership to implement ergonomics interventions, including a systematic process, to address exposure to risk factors that may result in musculoskeletal disorders or other types of injuries/illnesses. As a result of this partnership, an ergonomics process was integrated with the existing safety and health programme to promote an on-going application of ergonomics principles, and over 40 task-specific interventions were implemented during the first year of the process. This paper presents details of the process integration, and several examples of task-specific interventions that reduced exposure to risk factors. JF - International journal of occupational safety and ergonomics : JOSE AU - Torma-Krajewski, Janet AD - National Institute for Occupational Safety and Health (NIOSH), Pittsburgh, PA, USA. jtorma@mines.edu Y1 - 2008 PY - 2008 DA - 2008 SP - 351 EP - 359 VL - 14 IS - 3 SN - 1080-3548, 1080-3548 KW - Index Medicus KW - Musculoskeletal Diseases -- prevention & control KW - Humans KW - Occupational Diseases -- prevention & control KW - Program Development KW - Wisconsin KW - Occupational Health KW - Task Performance and Analysis KW - Mining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69720219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+safety+and+ergonomics+%3A+JOSE&rft.atitle=Ergonomics+interventions+at+Badger+Mining+Corporation.&rft.au=Torma-Krajewski%2C+Janet&rft.aulast=Torma-Krajewski&rft.aufirst=Janet&rft.date=2008-01-01&rft.volume=14&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+safety+and+ergonomics+%3A+JOSE&rft.issn=10803548&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preventable mix-ups of tuberculin and vaccines: reports to the US Vaccine and Drug Safety Reporting Systems. AN - 69646565; 18840022 AB - Errors involving the mix-up of tuberculin purified protein derivative (PPD) and vaccines leading to adverse reactions and unnecessary medical management have been reported previously. To determine the frequency of PPD-vaccine mix-ups reported to the US Vaccine Adverse Event Reporting System (VAERS) and the Adverse Event Reporting System (AERS), characterize adverse events and clusters involving mix-ups and describe reported contributory factors. We reviewed AERS reports from 1969 to 2005 and VAERS reports from 1990 to 2005. We defined a mix-up error event as an incident in which a single patient or a cluster of patients inadvertently received vaccine instead of a PPD product or received a PPD product instead of vaccine. We defined a cluster as inadvertent administration of PPD or vaccine products to more than one patient in the same facility within 1 month. Of 115 mix-up events identified, 101 involved inadvertent administration of vaccines instead of PPD. Product confusion involved PPD and multiple vaccines. The annual number of reported mix-ups increased from an average of one event per year in the early 1990s to an average of ten events per year in the early part of this decade. More than 240 adults and children were affected and the majority reported local injection site reactions. Four individuals were hospitalized (all recovered) after receiving the wrong products. Several patients were inappropriately started on tuberculosis prophylaxis as a result of a vaccine local reaction being interpreted as a positive tuberculin skin test. Reported potential contributory factors involved both system factors (e.g. similar packaging) and human errors (e.g. failure to read label before product administration). To prevent PPD-vaccine mix-ups, proper storage, handling and administration of vaccine and PPD products is necessary. JF - Drug safety AU - Chang, Soju AU - Pool, Vitali AU - O'Connell, Kathryn AU - Polder, Jacquelyn A AU - Iskander, John AU - Sweeney, Colleen AU - Ball, Robert AU - Braun, M Miles AD - Office of Biostatistics and Epidemiology, US Food and Drug Administration (FDA), 1401 Rockville Pike, Rockville, MD 20852, USA. sojuchang@hotmail.com Y1 - 2008 PY - 2008 DA - 2008 SP - 1027 EP - 1033 VL - 31 IS - 11 SN - 0114-5916, 0114-5916 KW - Tuberculin KW - 0 KW - Vaccines KW - Index Medicus KW - Young Adult KW - Humans KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - Adverse Drug Reaction Reporting Systems KW - Aged, 80 and over KW - Adult KW - Product Surveillance, Postmarketing KW - Databases, Factual KW - Middle Aged KW - Adolescent KW - Hospitalization -- statistics & numerical data KW - United States -- epidemiology KW - Male KW - Female KW - Vaccines -- adverse effects KW - Tuberculin -- adverse effects KW - Medication Errors -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69646565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Preventable+mix-ups+of+tuberculin+and+vaccines%3A+reports+to+the+US+Vaccine+and+Drug+Safety+Reporting+Systems.&rft.au=Chang%2C+Soju%3BPool%2C+Vitali%3BO%27Connell%2C+Kathryn%3BPolder%2C+Jacquelyn+A%3BIskander%2C+John%3BSweeney%2C+Colleen%3BBall%2C+Robert%3BBraun%2C+M+Miles&rft.aulast=Chang&rft.aufirst=Soju&rft.date=2008-01-01&rft.volume=31&rft.issue=11&rft.spage=1027&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-30 N1 - Date created - 2008-10-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of false positive rates of peto and poly-3 methods for long-term carcinogenicity data analysis using multiple comparison adjustment method suggested by Lin and Rahman. AN - 69536085; 18781527 AB - Statistical analyses of two-year carcinogenicity data include tests for dose-response relationship (positive trend) among the increasing doses and pairwise comparisons of treated groups with control in tumor incidence by organ/tumor combination. There are two major concerns in analyzing carcinogenicity data, namely, adjustment for the difference in mortality due to drug toxicity and adjustment for the multiplicity due to multiple testing of trends and pairwise differences by organ tumor combination. A widely used method for testing dose-response relationship is the method suggested by Peto et al. (Peto test). The Peto test adjusts the mortality differences among treatment groups by partitioning the entire study period into several intervals, analyzing the data separately for each interval, and then combining them using the Mantel-Haenszel procedure. The denominator for the calculation of the proportion of tumor bearing animals is determined from the cause of death information tumor data. In later works, researchers have expressed concerns regarding the construction of suitable intervals for mortality adjustment. Also according to the opinion of many pathologists it is difficult to accurately specify retrospectively if a tumor is the real cause of death of an animal. This information may be imprecise. Hence, many times results of analysis using the Peto test are questioned due to the inaccurate cause of death information. An alternative to the Peto test was suggested by Bailer and Portier, popularly known as Poly-K test. Unlike the Peto test, this test does not need any arbitrary partitioning of the study period or the cause of death information. This test for trend in tumor incidence adjusts the differences in mortality among treatment groups by assigning a weight of less than one to an animal that died early without developing the tumor; and a weight of one to an animal that died with the tumor or survived to the end of the study. The sum of the assigned weights of animals in a treatment group is then used as the denominator for the calculation of proportion of tumor-bearing animals for the group. The less-than-one weight assigned to an animal is the fraction of the animal's surviving time in the study over the maximum time of the study with a power k. The power k of the fraction is determined by the distribution of tumor onset times of the tumor. The Poly-K test may have some advantages over the Peto test in the sense that it does not require the cause of death information, which is an essential part for the Peto test. However, the performance of the Poly-K test in controlling the false positive rate in comparison to the Peto test is unknown and of great interest in the regulatory environment. In this work the authors compared the overall false positive rates of the Peto and Poly-K tests using the Lin-Rahman multiple comparison adjustment based on some simulation results. JF - Journal of biopharmaceutical statistics AU - Rahman, Mohammad A AU - Lin, Karl K AD - Division of Biometrics 6, Office of Biostatistics/Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. mohammad.rahman@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 949 EP - 958 VL - 18 IS - 5 KW - Index Medicus KW - Animals KW - Neoplasms, Experimental -- chemically induced KW - Dose-Response Relationship, Drug KW - Neoplasms, Experimental -- mortality KW - Carcinogenicity Tests -- methods KW - Data Interpretation, Statistical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69536085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=A+comparison+of+false+positive+rates+of+peto+and+poly-3+methods+for+long-term+carcinogenicity+data+analysis+using+multiple+comparison+adjustment+method+suggested+by+Lin+and+Rahman.&rft.au=Rahman%2C+Mohammad+A%3BLin%2C+Karl+K&rft.aulast=Rahman&rft.aufirst=Mohammad&rft.date=2008-01-01&rft.volume=18&rft.issue=5&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400802287628 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400802287628 ER - TY - JOUR T1 - Identifying high-dimensional biomarkers for personalized medicine via variable importance ranking. AN - 69534717; 18781521 AB - We apply robust classification algorithms to high-dimensional genomic data to find biomarkers, by analyzing variable importance, that enable a better diagnosis of disease, an earlier intervention, or a more effective assignment of therapies. The goal is to use variable importance ranking to isolate a set of important genes that can be used to classify life-threatening diseases with respect to prognosis or type to maximize efficacy or minimize toxicity in personalized treatment of such diseases. A ranking method and present several other methods to select a set of important genes to use as genomic biomarkers is proposed, and the performance of the selection procedures in patient classification by cross-validation is evaluated. The various selection algorithms are applied to published high-dimensional genomic data sets using several well-known classification methods. For each data set, a set of genes selected on the basis of variable importance that performed the best in classification is reported. That classification algorithm with the proposed ranking method is shown to be competitive with other selection methods for discovering genomic biomarkers underlying both adverse and efficacious outcomes for improving individualized treatment of patients for life-threatening diseases. JF - Journal of biopharmaceutical statistics AU - Baek, Songjoon AU - Moon, Hojin AU - Ahn, Hongshik AU - Kodell, Ralph L AU - Lin, Chien-Ju AU - Chen, James J AD - Division of Personalized Nutrition and Medicine-Biometry Branch, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 853 EP - 868 VL - 18 IS - 5 KW - Biomarkers KW - 0 KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Prognosis KW - Leukemia, Myeloid, Acute -- mortality KW - Lymphoma -- classification KW - Lymphoma -- genetics KW - Leukemia, Myeloid, Acute -- genetics KW - Algorithms KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69534717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Identifying+high-dimensional+biomarkers+for+personalized+medicine+via+variable+importance+ranking.&rft.au=Baek%2C+Songjoon%3BMoon%2C+Hojin%3BAhn%2C+Hongshik%3BKodell%2C+Ralph+L%3BLin%2C+Chien-Ju%3BChen%2C+James+J&rft.aulast=Baek&rft.aufirst=Songjoon&rft.date=2008-01-01&rft.volume=18&rft.issue=5&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400802278023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400802278023 ER - TY - JOUR T1 - Summary health statistics for the U.S. population: National Health Interview Survey, 2006. AN - 69317928; 18624012 AB - This report presents both age-adjusted and unadjusted health statistics from the 2006 National Health Interview Survey (NHIS) for the civilian noninstitutionalized population of the United States, classified by sex, age, race, Hispanic or Latino origin and race, education, family income, poverty status, health insurance coverage (where appropriate), place of residence, and region of residence. The topics covered are respondent-assessed health status, limitations in activities, special education or early intervention services, injury and poisoning episodes, health care access and utilization, and health insurance coverage. NHIS is a household, multistage probability sample survey conducted annually by interviewers of the U.S. Census Bureau for the Centers for Disease Control and Prevention's National Center for Health Statistics. In 2006, household interviews were completed for 75,716 persons living in 29,204 households, reflecting a household response rate of 87.3%. Nearly 7 in 10 persons were in excellent or very good health in 2006. About 36 million persons (12%) were limited in their usual activities due to one or more chronic health conditions. About 4 million persons (2%) required the help of another person with activities of daily living, and about 8 million persons (4%) required the help of another person with instrumental activities of daily living. About 6% of children received special education or early intervention services. Among persons under age 65 years, about 43 million (17%) did not have any health insurance coverage. The most common reason for lacking health insurance was cost, followed by a change in employment. JF - Vital and health statistics. Series 10, Data from the National Health Survey AU - Adams, Patricia F AU - Lucas, Jacqueline Wilson AU - Barnes, Patricia M AD - Division of Health Interview Statistics, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, Maryland 20782, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 1 EP - 104 IS - 236 SN - 0083-1972, 0083-1972 KW - Index Medicus KW - Wounds and Injuries -- epidemiology KW - Humans KW - Poisoning -- epidemiology KW - Activities of Daily Living KW - Aged KW - Child KW - Child, Preschool KW - Demography KW - Infant KW - Education, Special -- statistics & numerical data KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Insurance Coverage -- statistics & numerical data KW - Health Surveys KW - Health Status KW - Health Services Accessibility -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69317928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vital+and+health+statistics.+Series+10%2C+Data+from+the+National+Health+Survey&rft.atitle=Summary+health+statistics+for+the+U.S.+population%3A+National+Health+Interview+Survey%2C+2006.&rft.au=Adams%2C+Patricia+F%3BLucas%2C+Jacqueline+Wilson%3BBarnes%2C+Patricia+M&rft.aulast=Adams&rft.aufirst=Patricia&rft.date=2008-01-01&rft.volume=&rft.issue=236&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Vital+and+health+statistics.+Series+10%2C+Data+from+the+National+Health+Survey&rft.issn=00831972&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-05 N1 - Date created - 2008-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - To ban or not to ban--that is the question: the constitutionality of a moratorium on consumer drug advertising. AN - 69221723; 18561453 JF - Food and drug law journal AU - Schwartz, Mark I AD - Food and Drug Administration, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 1 EP - 33 VL - 63 IS - 1 SN - 1064-590X, 1064-590X KW - Pharmaceutical Preparations KW - 0 KW - Health technology assessment KW - United States KW - United States Food and Drug Administration KW - Supreme Court Decisions KW - Government Regulation KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Pharmaceutical Preparations -- economics KW - Community Participation KW - International Agencies KW - Guidelines as Topic KW - Patient Education as Topic -- legislation & jurisprudence KW - Drug Industry -- standards KW - Civil Rights -- legislation & jurisprudence KW - Advertising as Topic -- legislation & jurisprudence KW - Advertising as Topic -- standards KW - Legislation, Drug KW - Drug Industry -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69221723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+drug+law+journal&rft.atitle=To+ban+or+not+to+ban--that+is+the+question%3A+the+constitutionality+of+a+moratorium+on+consumer+drug+advertising.&rft.au=Schwartz%2C+Mark+I&rft.aulast=Schwartz&rft.aufirst=Mark&rft.date=2008-01-01&rft.volume=63&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Food+and+drug+law+journal&rft.issn=1064590X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-26 N1 - Date created - 2008-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Statistical issues including design and sample size calculation in thorough QT/QTc studies. AN - 69205031; 18470755 AB - After several drugs were removed from the market in recent years because of death due to ventricular tachycardia resulting from drug-induced QT prolongation (Khongphatthanayothin et al., 1998; Lasser et al., 2002; Pratt et al., 1994; Wysowski et al., 2001), the ICH Regulatory agencies requested all sponsors of new drugs to conduct a clinical study, named a Thorough QT/QTc (TQT) study, to assess any possible QT prolongation due to the study drug. The final version of the ICH E14 guidance (ICH, 2005) for "The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Nonantiarrhythmic Drugs" was released in May 2005. The purpose of the ICH E14 guidance (ICH, 2005) is to provide recommendations to sponsors concerning the design, conduct, analysis, and interpretation of clinical studies to assess the potential of a drug to delay cardiac repolarization. The guideline, however, is not specific on several issues. In this paper, we try to address some statistical issues, including study design, primary statistical analysis, assay sensitivity analysis, and the calculation of the sample size for a TQT study. JF - Journal of biopharmaceutical statistics AU - Zhang, Joanne AU - Machado, Stella G AD - Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Joanne.Zhang@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 451 EP - 467 VL - 18 IS - 3 KW - Drugs, Investigational KW - 0 KW - Index Medicus KW - International Cooperation KW - Humans KW - Sample Size KW - Electrocardiography -- statistics & numerical data KW - Research Design -- statistics & numerical data KW - Heart Rate -- drug effects KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- diagnosis KW - Heart Rate -- physiology KW - Drugs, Investigational -- adverse effects KW - Long QT Syndrome -- physiopathology KW - Guidelines as Topic KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69205031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Statistical+issues+including+design+and+sample+size+calculation+in+thorough+QT%2FQTc+studies.&rft.au=Zhang%2C+Joanne%3BMachado%2C+Stella+G&rft.aulast=Zhang&rft.aufirst=Joanne&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400802020938 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400802020938 ER - TY - JOUR T1 - Validation testing in thorough QT/QTc clinical trials. AN - 69204374; 18470761 AB - In order to validate the results of a thorough QT/QTc (the duration of depolarization and repolarization of ventricles or the duration corrected for heart rate) clinical trial, ICH E14 recommended to include a concurrent positive control treatment in the trial. It further recommended that validation is achieved if the positive control has an effect on the mean QT/QTc interval of about 5 ms. Zhang (2008) discussed the intersection-union test approach for testing the validation hypotheses and an alternative global average test approach. In this article, we further discuss the difference and relationship of the two sets of hypotheses and the difference in the efficiencies of the two approaches. We conclude that validation can be achieved if either one test rejects the null hypotheses without inflating the family-wise Type I error rate. However, using both approaches may improve the efficiency in validation assessment. JF - Journal of biopharmaceutical statistics AU - Tsong, Yi AU - Zhong, Jinglin AU - Chen, Wen Jen AD - Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. yi.tsong@cder.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 529 EP - 541 VL - 18 IS - 3 KW - Anti-Infective Agents KW - 0 KW - Aza Compounds KW - Fluoroquinolones KW - Placebos KW - Quinolines KW - moxifloxacin KW - U188XYD42P KW - Index Medicus KW - Control Groups KW - Anti-Infective Agents -- adverse effects KW - Humans KW - Aza Compounds -- adverse effects KW - Guidelines as Topic KW - Quinolines -- adverse effects KW - Validation Studies as Topic KW - Electrocardiography -- standards KW - Heart Rate -- drug effects KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- diagnosis KW - Heart Rate -- physiology KW - Long QT Syndrome -- physiopathology KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69204374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Validation+testing+in+thorough+QT%2FQTc+clinical+trials.&rft.au=Tsong%2C+Yi%3BZhong%2C+Jinglin%3BChen%2C+Wen+Jen&rft.aulast=Tsong&rft.aufirst=Yi&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400801995486 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Biopharm Stat. 2010 May;20(3):683-7; author reply 688 [20358445] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400801995486 ER - TY - JOUR T1 - Statistical issues of QT prolongation assessment based on linear concentration modeling. AN - 69203431; 18470764 AB - The ICH (2005) defined drug-induced prolongation of QT interval, i.e., the duration of depolarization and repolarization of ventricles, as evidenced by an upper bound of the 95% confidence interval around the mean effect on QTc (QT corrected for heart rate) of 10 ms. Furthermore, it defined that a negative thorough QT/QTc study is one in which the upper bound of the 95% one-sided confidence interval for the largest time-matched mean effect of the drug on the QTc interval excludes 10 ms. This objective leads to the application of intersection-union tests by testing the mean difference between test treatment and placebo of QTc change from baseline at each of the matched time points at which the observations are collected. The nature of the higher false positive rate due to more observational time points leads to the concern of study efficiency. Based on the concept of clinical pharmacology, a concentration-response modeling approach is often adopted to assess the prolongation size of QTc interval induced by a drug without carefully examining the validity of the assumptions involved. In most of the applications, the model is assumed either to be linear, log-linear, or logistic. The supporter of the modeling often emphasizes the advantage of power improvement and reduction in estimation error. However, it has been often pointed out by statisticians and pharmacologists that modeling under an invalid uniformity assumption across study population often leads to severe bias in testing and estimation. In this article, we examine data sets of New Drug Applications to illustrate the bias and lack of validity of the linearity assumptions. JF - Journal of biopharmaceutical statistics AU - Tsong, Yi AU - Shen, Meiyu AU - Zhong, Jinglin AU - Zhang, Joanne AD - Division of Biometrics VI, Office of Biostatistics/Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. yi.tsong@cder.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 564 EP - 584 VL - 18 IS - 3 KW - Anti-Infective Agents KW - 0 KW - Aza Compounds KW - Fluoroquinolones KW - Quinolines KW - moxifloxacin KW - U188XYD42P KW - Index Medicus KW - Humans KW - Linear Models KW - Aza Compounds -- administration & dosage KW - Quinolines -- adverse effects KW - Quinolines -- administration & dosage KW - Anti-Infective Agents -- adverse effects KW - International Cooperation KW - Anti-Infective Agents -- administration & dosage KW - Aza Compounds -- adverse effects KW - Guidelines as Topic KW - Sample Size KW - Time Factors KW - Electrocardiography -- standards KW - Heart Rate -- drug effects KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- diagnosis KW - Heart Rate -- physiology KW - Long QT Syndrome -- physiopathology KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69203431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Statistical+issues+of+QT+prolongation+assessment+based+on+linear+concentration+modeling.&rft.au=Tsong%2C+Yi%3BShen%2C+Meiyu%3BZhong%2C+Jinglin%3BZhang%2C+Joanne&rft.aulast=Tsong&rft.aufirst=Yi&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400801995502 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Biopharm Stat. 2010 May;20(3):689-92; author reply 693-7 [20358447] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400801995502 ER - TY - JOUR T1 - Testing for positive control activity in a thorough QTc study. AN - 69202550; 18470760 AB - The ICH E14 guidance (ICH, 2005) recommend that a concurrent positive control should be included in a thorough QTc clinical trial to validate the study. The ICH E14 guidance (ICH, 2005) state that "The positive control should have an effect on the mean QTc interval of about 5 ms (i.e., an effect that is close to the QTc effect that represents the threshold of regulatory concern, around 5 ms)". This task may be carried out through some statistical tests. The current practice is to test at each time point where QT measurements are collected. This method is usually not efficient. In this article, I discuss two types of statistical procedures. The first one is a local statistical test to make a time-point-specific claim, i.e., to claim a mild QTc effect due to the positive control at some specific time points. A different approach, named as a global test, is also proposed, to make a general claim that the mean difference of the positive control and placebo after baseline adjustment will be about 5 ms without specifying at which time points. An example will be used to illustrate how to apply the two procedures. How to best allocate sample size in a parallel QTc study is also discussed in this paper. JF - Journal of biopharmaceutical statistics AU - Zhang, Joanne AD - Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Joanne.Zhang@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 517 EP - 528 VL - 18 IS - 3 KW - Index Medicus KW - Humans KW - Electrocardiography -- standards KW - Research Design -- statistics & numerical data KW - Heart Rate -- drug effects KW - Long QT Syndrome -- chemically induced KW - Control Groups KW - Long QT Syndrome -- diagnosis KW - Heart Rate -- physiology KW - Long QT Syndrome -- physiopathology KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69202550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Testing+for+positive+control+activity+in+a+thorough+QTc+study.&rft.au=Zhang%2C+Joanne&rft.aulast=Zhang&rft.aufirst=Joanne&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400801995478 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400801995478 ER - TY - JOUR T1 - Guest editors' notes on statistical issues in design and analysis of thorough QTc studies. AN - 69202047; 18470752 JF - Journal of biopharmaceutical statistics AU - Tsong, Yi AU - Zhang, Joanne AD - Division of Biometrics VI, Office of Biostatistics/Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. yi.tsong@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 405 EP - 407 VL - 18 IS - 3 KW - Placebos KW - 0 KW - Index Medicus KW - Heart Rate -- drug effects KW - Humans KW - Heart Rate -- physiology KW - Electrocardiography -- statistics & numerical data KW - Research Design -- statistics & numerical data KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- diagnosis KW - Long QT Syndrome -- physiopathology KW - Clinical Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69202047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Guest+editors%27+notes+on+statistical+issues+in+design+and+analysis+of+thorough+QTc+studies.&rft.au=Tsong%2C+Yi%3BZhang%2C+Joanne&rft.aulast=Tsong&rft.aufirst=Yi&rft.date=2008-01-01&rft.volume=18&rft.issue=3&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543400802029509 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543400802029509 ER - TY - JOUR T1 - Mining sector. AN - 69180082; 18454967 JF - Journal of safety research AU - Bealko, Susan B AU - Kovalchik, Peter G AU - Matetic, Rudy J AD - National Institute for Occupational Safety and Health (NIOSH), USA. sbealko@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 187 EP - 189 VL - 39 IS - 2 SN - 0022-4375, 0022-4375 KW - Index Medicus KW - Organizational Policy KW - Humans KW - Organizational Culture KW - Occupational Health KW - Environment Design KW - Accidents, Occupational -- prevention & control KW - Workplace KW - Mining KW - Safety Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69180082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+safety+research&rft.atitle=Mining+sector.&rft.au=Bealko%2C+Susan+B%3BKovalchik%2C+Peter+G%3BMatetic%2C+Rudy+J&rft.aulast=Bealko&rft.aufirst=Susan&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Journal+of+safety+research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-15 N1 - Date created - 2008-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jsr.2008.02.004 ER - TY - JOUR T1 - National Prevention through Design (PtD) Initiative. AN - 69174412; 18454950 AB - The most effective means of preventing and controlling occupational injuries, illness, and fatalities is to "design out" hazards and hazardous exposures from the workplace. There is a long history of designing for safety for the general public and to a lesser degree for workers. We now have the experience and insight from thoughtful, previous efforts to call for a comprehensive national strategy to implement a Prevention through Design (PtD) Initiative. This paper describes that initiative in terms of four overarching areas where action can be directed: practice, policy, research, and education. To obtain stakeholder input for issues in these four areas and to focus implementation efforts, eight sector divisions of the economy will be addressed. A seven year strategy is envisioned. JF - Journal of safety research AU - Schulte, Paul A AU - Rinehart, Richard AU - Okun, Andrea AU - Geraci, Charles L AU - Heidel, Donna S AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, USA. pas4@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 115 EP - 121 VL - 39 IS - 2 SN - 0022-4375, 0022-4375 KW - Index Medicus KW - United States KW - Humans KW - Public Policy KW - Occupational Health KW - Accidents, Occupational -- prevention & control KW - Safety Management -- standards KW - Environment Design -- standards KW - Workplace -- standards KW - Program Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69174412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+safety+research&rft.atitle=National+Prevention+through+Design+%28PtD%29+Initiative.&rft.au=Schulte%2C+Paul+A%3BRinehart%2C+Richard%3BOkun%2C+Andrea%3BGeraci%2C+Charles+L%3BHeidel%2C+Donna+S&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Journal+of+safety+research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-15 N1 - Date created - 2008-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jsr.2008.02.021 ER - TY - JOUR T1 - Quality control of microarray assays for toxicogenomic and in vitro diagnostic applications. AN - 69160134; 18449482 AB - The generation of high-quality microarray data for toxicogenomics can be affected by the study design and methods used for sample acquisition, preparation, and processing. Bias can be introduced during animal treatment, tissue handling, and sample preparation. Metrics and controls used in assessing RNA integrity and the quality of microarray sample generation are reviewed in this chapter. Regulations and guidelines involved in the application of microarrays as a commercial in vitro diagnostic device are also described. JF - Methods in molecular biology (Clifton, N.J.) AU - Thompson, Karol L AU - Hackett, Joseph AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 45 EP - 68 VL - 460 SN - 1064-3745, 1064-3745 KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - In Vitro Techniques KW - Diagnostic Tests, Routine KW - Quality Control KW - Toxicology KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69160134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Quality+control+of+microarray+assays+for+toxicogenomic+and+in+vitro+diagnostic+applications.&rft.au=Thompson%2C+Karol+L%3BHackett%2C+Joseph&rft.aulast=Thompson&rft.aufirst=Karol&rft.date=2008-01-01&rft.volume=460&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-60327-048-9_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-05 N1 - Date created - 2008-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-048-9_3 ER - TY - JOUR T1 - Informatic tools and approaches in postmarketing pharmacovigilance used by FDA. AN - 69157025; 18446503 AB - The safety profile of newly approved drugs and therapeutic biologics is less well developed by pre-marketing clinical testing than is the efficacy profile. The full safety profile of an approved product is established during years of clinical use. For nearly 40 years, the FDA has relied on the voluntary reporting of adverse events by healthcare practitioners and patients to help establish the safety of marketed products. Epidemiologic studies, including case series, secular trends, case-control and cohort studies, are used to supplement the investigation of a safety signal. Ideally, active surveillance systems would supplement the identification and exploration of safety signals. The FDA has implemented a number of initiatives to help identify safety problems with drugs and continues to evaluate their efforts. JF - The AAPS journal AU - Weaver, Joyce AU - Willy, Mary AU - Avigan, Mark AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20903-0002, USA. joyce.weaver@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 35 EP - 41 VL - 10 IS - 1 KW - Drugs, Investigational KW - 0 KW - Index Medicus KW - United States KW - Drugs, Investigational -- pharmacology KW - Animals KW - Adverse Drug Reaction Reporting Systems -- standards KW - Humans KW - Adverse Drug Reaction Reporting Systems -- trends KW - Drugs, Investigational -- adverse effects KW - Medical Informatics -- trends KW - United States Food and Drug Administration -- trends KW - Medical Informatics -- standards KW - United States Food and Drug Administration -- standards KW - Product Surveillance, Postmarketing -- trends KW - Product Surveillance, Postmarketing -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69157025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Informatic+tools+and+approaches+in+postmarketing+pharmacovigilance+used+by+FDA.&rft.au=Weaver%2C+Joyce%3BWilly%2C+Mary%3BAvigan%2C+Mark&rft.aulast=Weaver&rft.aufirst=Joyce&rft.date=2008-01-01&rft.volume=10&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-007-9004-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-22 N1 - Date created - 2008-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Saf. 2002;25(6):381-92 [12071774] Drug Saf. 2003;26(3):159-86 [12580646] Hepatology. 2004 Oct;40(4):773 [15382161] J R Soc Med. 1991 Jun;84(6):341-4 [2061900] JAMA. 2006 Oct 18;296(15):1858-66 [17047216] Chest. 2006 Jan;129(1):15-26 [16424409] N Engl J Med. 2006 Mar 2;354(9):924-33 [16510746] Arch Gen Psychiatry. 2006 Mar;63(3):332-9 [16520440] Basic Clin Pharmacol Toxicol. 2006 Mar;98(3):311-3 [16611207] Drug Saf. 2005;28(10):917-24 [16180941] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1208/s12248-007-9004-5 ER - TY - RPRT T1 - National Survey of Child and Adolescent Well-Being, No. 12: Estimates of Supplemental Security Income Eligibility for Children in Out-of-Home Placements. Research Brief: Findings from the NSCAW Study AN - 61960813; ED501307 AB - Children who have been placed in foster care have been found to be at a high risk of having a medical, social or behavioral disability. This brief, one in a series of briefs addressing access to services for children in the child welfare system, examines Supplemental Security Income (SSI) eligibility among children living in out-of-home placements in the child welfare system, using data from the National Survey of Child and Adolescent Well-Being. The analysis indicates that a large number of children living in foster care may be eligible for SSI. The rates of SSI eligibility we estimate vary depending on children's age, race/ethnicity, gender and locality of placement. (Contains 4 tables and 11 notes.) Y1 - 2008 PY - 2008 DA - 2008 SP - 8 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - At Risk Persons KW - Gender Differences KW - Place of Residence KW - Welfare Services KW - Racial Differences KW - Foster Care KW - Child Welfare KW - Age Differences KW - Eligibility KW - Placement KW - Income UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61960813?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - BOOK T1 - Monitoring and Technical Assistance Review System Notebook AN - 61959051; ED501839 AB - This notebook provides guidance on the Monitoring and Technical Assistance Review System (MTARS). The manual is intended for use by Administration on Developmental Disabilities (ADD) staff who manage MTARS and by MTARS reviewers who conduct site visit activities. The notebook is also designed to help Councils, Protection and Advocacy Systems, and University Centers for Excellence in Developmental Disabilities prepare for and participate in MTARS activities. The notebook describes procedures for each stage of the MTARS process and is organized into seven sections: (1) Overview of the Developmental Disabilities Assistance and Bill of Rights Act of 2000 (DD Act) and ADD; (2) Monitoring and Technical Assistance Review System; (3) MTARS Team; (4) Planning Activities; (5) Pre-Site Visit Activities; (6) MTARS Site Visit; and (7) Post-Site Visit Activities. Tables, checklists, glossary and additional information are appended. (Contains 31 tables.) Y1 - 2008 PY - 2008 DA - 2008 SP - 223 PB - Administration for Children & Families. U.S. Department of Health and Human Services, 380 L'Enfant Promenade SW, Washington, DC 20447. KW - Developmental Disabilities Act KW - Developmental Disabled Assist Bill of Rights Act KW - ERIC, Resources in Education (RIE) KW - Administrators KW - Self Evaluation (Individuals) KW - Developmental Disabilities KW - Grants KW - Observation KW - Evaluators KW - Accountability KW - Human Services KW - Federal Legislation KW - Public Agencies KW - Innovation KW - Planning KW - Check Lists KW - Compliance (Legal) KW - Program Evaluation KW - Technical Assistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61959051?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - More about the Dads: Exploring Associations between Nonresident Father Involvement and Child Welfare Case Outcomes AN - 61947640; ED501299 AB - This study follows up on a prior study of child welfare agencies' efforts to identify, locate, and involve nonresident fathers of children in foster care. These analyses use information from the original survey and administrative data on case outcomes to explore three research questions: (1) Is nonresident father involvement associated with case length? (2) Is nonresident father involvement associated with foster care discharge outcomes? and (3) Is nonresident father involvement associated with subsequent child maltreatment allegations? The study finds that having an involved father is associated with shorter case length and a greater likelihood of reunification. Findings also indicate that, contrary to some caseworkers' fears, nonresident fathers' contact with the child welfare agency and involvement with their children is not associated with subsequent maltreatment allegations. The results, though exploratory, suggest that engaging the nonresident fathers of children in foster care could potentially improve outcomes for the children. Further research is needed to better understand the association between nonresident fathers' involvement and a greater likelihood of reunification. (Contains 2 tables, 7 figures, and 34 footnotes.) [This report was prepared by the Urban Institute under contract to the Office of the Assistant Secretary for Planning and Evaluation of the U.S. Department of Health and Human Services.] AU - Malm, Karin AU - Zielewski, Erica AU - Chen, Henry Y1 - 2008 PY - 2008 DA - 2008 SP - 30 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Followup Studies KW - Parent Child Relationship KW - Welfare Services KW - Child Abuse KW - Fathers KW - Child Welfare KW - Foster Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61947640?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Substance Abuse and Mental Health Services Administration. March/April 2008 AN - 61947049; ED501549 AB - "SAMHSA News" is the national newsletter of the Substance Abuse and Mental Health Services Administration. Published six times a year (bimonthly) by SAMHSA's Office of Communications, SAMHSA News contains information about the latest substance abuse and mental health treatment and prevention practices, recent statistics on mental health and addictive disorders, related Federal policies, and available resources. Articles in this issue include: (1) Screening Works: Update from the Field (Rebecca A. Clay); (2) Administrator's Message: Behavioral Health Screening and Primary Care (Terry L. Cline); (3) Screening in Action: For SBIRT Grantees Across the Nation, Flexibility Helps (Rebecca A. Clay); (4) President's Budget Focuses on Priority Initiatives; (5) Teens and Drug Use: Stimulant Use and Delinquent Behavior; (6) Statistics on Inhalants Show Young Teens at Risk; (7) State by State: Substance Use, Mental Health Statistics; (8) New Data on Treatment Admissions: Alcohol Abuse Highest, but Methamphetamine, Marijuana, Prescription Painkillers on the Rise; (9) Study Helps Dispel Substance Use Myth: Rural Communities at Risk (Erin Bryant); and (10) Making Workplaces Drug-Free. AU - Goodman, Deborah Y1 - 2008 PY - 2008 DA - 2008 SP - 16 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov VL - 16 IS - 2 KW - ERIC, Resources in Education (RIE) KW - At Risk Persons KW - Substance Abuse KW - Statistics KW - Delinquency KW - Grants KW - Mental Health Programs KW - Stimulants KW - Mental Health KW - Marijuana KW - Behavior Problems KW - Rural Areas KW - Screening Tests KW - Health Services KW - Alcohol Abuse KW - Inhalants KW - Misconceptions KW - Occupational Safety and Health KW - Incidence KW - Budgets KW - Work Environment KW - Adolescents KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61947049?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Connecting Social and Emotional Learning with Mental Health AN - 61893862; ED505361 AB - As knowledge of effective treatments for mental disorders has grown, so too has the field of mental health promotion and positive development. Studies completed during the last two decades have synthesized the state of mental health promotion and documented that universal mental health supports positively affect child and adolescent developmental outcomes. Given schools' ability to access large numbers of children, they are commonly identified as the best place to provide supports to promote the universal mental health of children. This report explains the relationship between mental health and the promotion of social and emotional learning (SEL). Strategies for connecting mental health and SEL in the school setting include: (1) Implementing supportive public policies; (2) Developing safe, caring, and supportive environments; (3) Providing direct instruction for students on skills and strategies; (4) Creating infrastructure for community action; and (5) Coordinating with community agencies, schools, families, and students to create a common vision, language, and coordinated services to support healthy outcomes. A list of resources is included. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 9 PB - Collaborative for Academic, Social, and Emotional Learning. 815 West Van Buren Street Suite 210, Chicago, IL 60607. KW - ERIC, Resources in Education (RIE) KW - Elementary Secondary Education KW - Program Effectiveness KW - Community Action KW - Guidelines KW - Child Health KW - Mental Health KW - Public Policy KW - Emotional Development KW - Health Promotion KW - Educational Environment KW - Public Health KW - Public Agencies KW - Mental Disorders KW - Program Implementation KW - School Role KW - Program Development KW - Social Development KW - Program Evaluation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61893862?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Social and Emotional Learning (SEL) and Student Benefits: Implications for the Safe Schools/Healthy Students Core Elements AN - 61890878; ED505369 AB - This brief shares the latest research on the effects of social and emotional learning (SEL) on students and includes strategies for implementing SEL. It explains how SEL works, elaborates on how SEL can be an integrative prevention framework that addresses the Safe Schools/Healthy Students (SS/HS) core elements, and spells out implications of the research for SS/HS grantees. Several hundred well-designed studies have documented the effects of SEL programming on students of diverse backgrounds, from preschool through high school, in urban, suburban, and rural settings. The research indicates that well-planned and well-implemented SEL programming can positively affect a broad range of student social, health, behavioral, and academic outcomes. (Contains 22 endnotes, 1 figure and 1 table.) Y1 - 2008 PY - 2008 DA - 2008 SP - 12 PB - Collaborative for Academic, Social, and Emotional Learning. 815 West Van Buren Street Suite 210, Chicago, IL 60607. KW - ERIC, Resources in Education (RIE) KW - Elementary Secondary Education KW - Program Effectiveness KW - Research Reports KW - Child Health KW - School Safety KW - Emotional Development KW - Outcomes of Education KW - Prevention KW - Educational Environment KW - Program Implementation KW - Federal Programs KW - Program Development KW - Social Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61890878?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - U.S. Health Spending By Age, Selected Years Through 2004: Recent trends indicate that per person spending for the oldest elderly is growing more slowly than spending for all other age groups AN - 58774822; 2008-171174 AB - This paper examines variations in health spending by children, working-age adults, and seniors for selected years between 1987 and 2004. Seniors spent far more per person than children or working-age adults, but the relative gap between the age groups has not changed much since 1987 except for those age eighty-five and older. Since the inception of the State Children's Health Insurance Program (SCHIP) in 1997, the proportion of children's health spending financed by public sources has increased, while the share paid for out of pocket has decreased. The future age-mix is expected to have a major impact on nursing home spending growth while minimally affecting overall Medicare spending growth. Adapted from the source document. JF - Health Affairs AU - Hartman, Micah AU - Catlin, Aaron AU - Lassman, David AU - Cylus, Jonathan AU - Heffler, Stephen AD - National Health Statistics Group, Office of the Actuary, Centers for Medicare and Medicaid Services, Baltimore, Maryland micah.hartman@cms.hhs.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - w1 EP - w12 PB - Project HOPE, Bethesda MD VL - 27 IS - Supplement SN - 0278-2715, 0278-2715 KW - Population groups, population policy, and demographics - Children and youth KW - Population groups, population policy, and demographics - Demography and census KW - Health conditions and policy - Health and health policy KW - Medicare KW - Old age KW - Health policy KW - Adults KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58774822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=U.S.+Health+Spending+By+Age%2C+Selected+Years+Through+2004%3A+Recent+trends+indicate+that+per+person+spending+for+the+oldest+elderly+is+growing+more+slowly+than+spending+for+all+other+age+groups&rft.au=Hartman%2C+Micah%3BCatlin%2C+Aaron%3BLassman%2C+David%3BCylus%2C+Jonathan%3BHeffler%2C+Stephen&rft.aulast=Hartman&rft.aufirst=Micah&rft.date=2008-01-01&rft.volume=27&rft.issue=Supplement&rft.spage=w1&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.27.1.w1 LA - English DB - PAIS Index N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health policy; Children; Adults; Old age; Medicare DO - http://dx.doi.org/10.1377/hlthaff.27.1.w1 ER - TY - BOOK T1 - Guidelines for the Development of a New Miner Training Curriculum AN - 58769727; 2008-150286 AB - This report is intended to help mine safety trainers better prepare to teach the influx of new underground coal miners who are entering the industry. This is done by identifying two different approaches to instruction and discussing the ways they may affect how well prepared new hires are to deal with a dynamic and hazardous workplace. One approach is based on the use of a syllabus. Those using a syllabus are more likely to rely on lecturing or direct instruction. This is a good way to get across factual information, but does not provide a context within which miners can fit the discrete facts so that they form an integrated whole set of concepts, principles, and skills. The other approach is based on the use of a curriculum. Those using a curriculum may be more likely to help miners integrate concepts and skills that give them an overall picture of the complex mining environment and how they fit into the workplace. Tables, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Jan 2008, 30 pp. AU - Mallett, Launa G AU - Vaught, Charles Y1 - 2008/01// PY - 2008 DA - January 2008 EP - 30p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Mining and mineral resources KW - Education and education policy - Curriculum KW - Business and service sector - Business operations, practices, and workplaces KW - Social conditions and policy - Public safety and security KW - Curriculum KW - Miners KW - Safety measures KW - Workplaces KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58769727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Mallett%2C+Launa+G%3BVaught%2C+Charles&rft.aulast=Mallett&rft.aufirst=Launa&rft.date=2008-01-01&rft.volume=&rft.issue=&rft.spage=30p&rft.isbn=&rft.btitle=Guidelines+for+the+Development+of+a+New+Miner+Training+Curriculum&rft.title=Guidelines+for+the+Development+of+a+New+Miner+Training+Curriculum&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2008-105.pdf LA - English DB - PAIS Index N1 - Date revised - 2008-06-04 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - SuppNotes - NIOSH Publication No. 2008-105 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Health Spending Projections through 2017: The Baby-Boom Generation is Coming to Medicare. Accelerating growth in Medicare spending by the end of the projection period is the first sign of the coming demographic shift. AN - 58768017; 2008-173726 AB - The outlook for national health spending calls for continued steady growth. Spending growth is projected to be 6.7 percent in 2007, similar to its rate in 2006. Average annual growth over the projection period is expected to be 6.7 percent. Slower growth in private spending toward the end of the period is expected to be offset by stronger growth in public spending. The health share of gross domestic product (GDP) is expected to increase to 16.3 percent in 2007 & then rise throughout the projection period, reaching 19.5 percent of GDP by 2017. Tables, Graphs. Adapted from the source document. JF - Health Affairs AU - Keehan, Sean AU - Sisko, Andrea AU - Truffer, Christopher AU - Smith, Sheila AU - Cowan, Cathy AU - Poisal, John AU - Clemens, M Kent AU - National Health Expenditure Accounts Projections Team AD - NHSG e-mail:DNHS@cms.hhs.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - w145 EP - w155 PB - Project HOPE, Bethesda MD VL - 27 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Economic conditions and policy - Economic conditions KW - Medicare KW - Health policy KW - Economic conditions KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58768017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Health+Spending+Projections+through+2017%3A+The+Baby-Boom+Generation+is+Coming+to+Medicare.+Accelerating+growth+in+Medicare+spending+by+the+end+of+the+projection+period+is+the+first+sign+of+the+coming+demographic+shift.&rft.au=Keehan%2C+Sean%3BSisko%2C+Andrea%3BTruffer%2C+Christopher%3BSmith%2C+Sheila%3BCowan%2C+Cathy%3BPoisal%2C+John%3BClemens%2C+M+Kent%3BNational+Health+Expenditure+Accounts+Projections+Team&rft.aulast=Keehan&rft.aufirst=Sean&rft.date=2008-01-01&rft.volume=27&rft.issue=&rft.spage=w145&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medicare; Health policy; Economic conditions ER - TY - JOUR T1 - National Health Spending In 2006: A Year Of Change For Prescription Drugs AN - 58755374; 2008-127806 AB - In 2006, U.S. health care spending increased 6.7 percent to $.1 trillion, or $7,026 per person. The health care portion of gross domestic product (GDP) was 16.0 percent, slightly higher than in 2005. Prescription drug spending growth accelerated in 2006 to 8.5 percent, partly as a result of Medicare Part D's impact. Most of the other major health care services and public payers experienced slower growth in 2006 than in prior years. The implementation of Medicare Part D caused a major shift in the distribution of payers for prescription drugs, as Medicare played a larger role in drug purchases than it had before. Adapted from the source document. JF - Health Affairs AU - Catlin, Aaron AU - Cowan, Cathy AU - Hartman, Micah AU - Heffler, Stephen AD - National Health Statistics Group, CMS Office, Actuary, Catlin aaron.catlin@cms.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 14 EP - 29 PB - Project HOPE, Bethesda MD VL - 27 IS - 1 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Business and service sector - Business finance KW - Health conditions and policy - Medicine and health care KW - Manufacturing and heavy industry - Pharmaceutical industry KW - Prescriptions KW - Public health administration KW - United States KW - Finance KW - Appropriations and expenditures KW - Medicare KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58755374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=National+Health+Spending+In+2006%3A+A+Year+Of+Change+For+Prescription+Drugs&rft.au=Catlin%2C+Aaron%3BCowan%2C+Cathy%3BHartman%2C+Micah%3BHeffler%2C+Stephen&rft.aulast=Catlin&rft.aufirst=Aaron&rft.date=2008-01-01&rft.volume=27&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.27.1.14 LA - English DB - PAIS Index N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States; Public health administration; Finance; Prescriptions; Medicare; Appropriations and expenditures DO - http://dx.doi.org/10.1377/hlthaff.27.1.14 ER - TY - JOUR T1 - Laws, leaders, and legends of the modern National Library of Medicine. AN - 57708135; 200804798 AB - Purpose: The paper is an expanded version of the 2007 Joseph Leiter National Library of Medicine (NLM)/Medical Library Association Lecture presented at MLA '07, the Medical Library Association annual meeting in Philadelphia in May 2007. It presents an historical accounting of four major pieces of legislation, beginning with the NLM Act of 1956 up through the creation of the National Center for Biotechnology Information. Brief Description: The transition from the United States Armed Forces Medical Library to the United States National Library of Medicine in 1956 was a major turning point in NLM's history, scope, and direction. The succeeding landmark legislative achievements - namely, the 1965 Medical Library Assistance Act, the 1968 Joint Resolution forming the Lister Hill National Center for Biomedical Communications, and the 1988 authorization for the National Center for Biotechnology Information - transformed the library into a major biomedical communications institution and a leader and supporter of an effective national network of libraries of medicine. The leaders of the library and its major advocates - including Dr. Michael DeBakey, Senator Lister Hill, and Senator Claude Pepper - together contributed to the creation of the modern NLM. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Smith, Kent A AD - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894 ksmith@kasenterprise.com Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 121 EP - 133 PB - Medical Library Association, Chicago, IL VL - 96 IS - 2 SN - 1536-5050, 1536-5050 KW - National Library of Medicine, USA KW - Law KW - Library history KW - Medical libraries KW - article KW - 3.19: SCIENCE, TECHNOLOGY, MEDICINE LIBRARIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57708135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Laws%2C+leaders%2C+and+legends+of+the+modern+National+Library+of+Medicine.&rft.au=Smith%2C+Kent+A&rft.aulast=Smith&rft.aufirst=Kent&rft.date=2008-01-01&rft.volume=96&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.96.2.121 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical libraries; Library history; Law; National Library of Medicine, USA DO - http://dx.doi.org/10.3163/1536-5050.96.2.121 ER - TY - JOUR T1 - A Concept Analysis: Adherence and Weight Loss AN - 57299521; 200916884 AB - There are numerous factors that influence an individual's ability to adhere to a healthy behavior. The literature cites common events that must take place prior to maintaining an exercise plan, a medication regimen, and a healthy diet. The purpose of this paper is to examine the concept of adherence in relation to weight loss using Walker and Avant's (1995) framework for concept analysis. This analysis revealed an extensive list of events or antecedents that may prove to be important when considering new strategies for weight management. Adapted from the source document. JF - Nursing Forum AU - Shay, Laura E AD - Uniformed Services University, Bethesda, MD laura.shay@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 42 EP - 52 PB - Wiley-Blackwell, UK VL - 43 IS - 1 SN - 0029-6473, 0029-6473 KW - Healthy habits KW - Concept analysis KW - Adherence KW - Weight loss KW - Exercise KW - Diet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57299521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Forum&rft.atitle=A+Concept+Analysis%3A+Adherence+and+Weight+Loss&rft.au=Shay%2C+Laura+E&rft.aulast=Shay&rft.aufirst=Laura&rft.date=2008-01-01&rft.volume=43&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Nursing+Forum&rft.issn=00296473&rft_id=info:doi/10.1111%2Fj.1744-6198.2008.00095.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Weight loss; Adherence; Concept analysis; Diet; Exercise; Healthy habits DO - http://dx.doi.org/10.1111/j.1744-6198.2008.00095.x ER - TY - JOUR T1 - Perspective: Eyes on the prize: Federal Alzheimer's research effort aims to facilitate interventions AN - 57290372; 200915133 AB - The public Alzheimer's disease (AD) research enterprise began in earnest in the mid-1970s with the creation by Congress of the National Institute on Aging at the National Institutes of Health. Today, AD research is a maturing field of study, with federal effort seeking to encourage the creativity and insights of individual investigators, and targeting special areas for emphasis. It is inspired by the legacy of our friend and colleague Leon Thal, whose innovative and collaborative approach to scientific research serves as a guidepost as we move toward the discovery of new and effective ways to prevent AD or slow its progression. This article describes the progress to date and potentially promising areas of study from the vantage point of the National Institute on Aging. [Copyright Elsevier B.V.] JF - Alzheimer's & Dementia AU - Hodes, Richard J AU - Buckholtz, Neil AU - Cahan, Vicky AU - Morrison-Bogorad, Marcelle AD - National Institute on Aging, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA Y1 - 2008/01// PY - 2008 DA - January 2008 SP - S37 EP - S47 PB - Elsevier Ltd, The Netherlands VL - 4 IS - 1S1 SN - 1552-5260, 1552-5260 KW - Alzheimer's disease National Institute on Aging Dementia KW - Ageing KW - Congress KW - Alzheimer's disease KW - Creativity KW - Enterprises KW - Eyes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57290372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alzheimer%27s+%26+Dementia&rft.atitle=Perspective%3A+Eyes+on+the+prize%3A+Federal+Alzheimer%27s+research+effort+aims+to+facilitate+interventions&rft.au=Hodes%2C+Richard+J%3BBuckholtz%2C+Neil%3BCahan%2C+Vicky%3BMorrison-Bogorad%2C+Marcelle&rft.aulast=Hodes&rft.aufirst=Richard&rft.date=2008-01-01&rft.volume=4&rft.issue=1S1&rft.spage=S37&rft.isbn=&rft.btitle=&rft.title=Alzheimer%27s+%26+Dementia&rft.issn=15525260&rft_id=info:doi/10.1016%2Fj.jalz.2007.11.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alzheimer's disease; Ageing; Enterprises; Congress; Eyes; Creativity DO - http://dx.doi.org/10.1016/j.jalz.2007.11.002 ER - TY - JOUR T1 - Depression in Public Community Long-Term Care: Implications for Intervention Development AN - 57274785; 200916114 AB - The objective of this paper is to increase understanding of geriatric depression in the public community long-term care system to guide intervention development. Protocols included screening 1,170 new clients of a public community long-term care agency and interviewing all clients with major, dysthymia, or subthreshold depression (n=299) and a randomly selected subset of nondepressed older adults (n=315) at baseline, 6-month, and 1 year. Six percent had major depression, one-half of a percent had dysthymia only, and another 19% had subthreshold depression. Over the year observation period, 40% were persistently depressed; 32% were assessed as depressed only at the first observation; and the remainder was intermittently depressed. There were high levels of comorbid medical, functional, and psychosocial conditions. Mental health service use was low, and clients reported attitudinal and other barriers to depression treatment. Findings suggest the need for universal screening for depression with some strategies for triaging the most severely and persistently depressed for treatment. Although there will be challenges to the development of depression interventions, the public community long-term care system has high potential to assist vulnerable older adults receive help with depression. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Morrow-Howell, Nancy AU - Proctor, Enola AU - Choi, Sunha AU - Lawrence, Lisa AU - Brooks, Ashley AU - Hasche, Leslie AU - Dore, Peter AU - Blinne, Wayne AD - Center for Mental Health Services Research, Washington University, Campus Box 1196, St. Louis, MO 63130, USA morrow-howell@wustl.edu Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 37 EP - 51 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 35 IS - 1 SN - 1094-3412, 1094-3412 KW - Screening KW - Elderly people KW - Depression KW - Long term care KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57274785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Depression+in+Public+Community+Long-Term+Care%3A+Implications+for+Intervention+Development&rft.au=Morrow-Howell%2C+Nancy%3BProctor%2C+Enola%3BChoi%2C+Sunha%3BLawrence%2C+Lisa%3BBrooks%2C+Ashley%3BHasche%2C+Leslie%3BDore%2C+Peter%3BBlinne%2C+Wayne&rft.aulast=Morrow-Howell&rft.aufirst=Nancy&rft.date=2008-01-01&rft.volume=35&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-007-9098-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Depression; Long term care; Elderly people; Screening; Comorbidity DO - http://dx.doi.org/10.1007/s11414-007-9098-7 ER - TY - JOUR T1 - Policy and practice implications of epidemiological surveys on co-occurring mental and substance use disorders AN - 57259587; 200813506 AB - This article describes factors that influence national policy and practice, with particular focus on the implications of epidemiological survey research. Examples of areas of concern to policymakers include treatment-seeking patterns, access to care at points of service in public health and social service systems, evidence-based practices, workforce development, and the complexities of reimbursement. In responding to data on systemic barriers to care, the Substance Abuse and Mental Health Services Administration (SAMHSA) has sought to promote a no wrong door strategy to address the needs of persons with co-occurring disorders (CODs) involving their mental health and substance use. Examples of SAMHSA programs and policies addressing CODs discussed in this article include targeted partnerships with the states, mechanisms to enhance system infrastructure, technical assistance, and initiatives with special populations. [Copyright 2006 Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - Clark, H Westley AU - Power, A Kathryn AU - Le Fauve, Charlene E AU - Lopez, Elizabeth I AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, US Department of Health and Human Services, Rockville, MD westley.clark@samhsa.hhs.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 3 EP - 13 PB - Elsevier, New York NY VL - 34 IS - 1 SN - 0740-5472, 0740-5472 KW - Co-occurring disorders KW - SAMHSA KW - Epidemiology KW - NSDUH KW - Policy KW - Substance abuse disorders KW - Psychiatric disorders KW - Policy making KW - Comorbidity KW - Evidence based medicine KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57259587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Policy+and+practice+implications+of+epidemiological+surveys+on+co-occurring+mental+and+substance+use+disorders&rft.au=Clark%2C+H+Westley%3BPower%2C+A+Kathryn%3BLe+Fauve%2C+Charlene+E%3BLopez%2C+Elizabeth+I&rft.aulast=Clark&rft.aufirst=H&rft.date=2008-01-01&rft.volume=34&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2006.12.032 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Substance abuse disorders; Comorbidity; Psychiatric disorders; Helpseeking; Evidence based medicine; Policy making DO - http://dx.doi.org/10.1016/j.jsat.2006.12.032 ER - TY - JOUR T1 - The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of new psychiatric diagnostic modules and risk factors in a general population sample AN - 57229447; 200812587 AB - This study presents test-retest reliability statistics and information on internal consistency for new diagnostic modules and risk factors for alcohol, drug, and psychiatric disorders from the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV). Test-retest statistics were derived from a random sample of 1899 adults selected from 34,653 respondents who participated in the 2004-2005 Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Internal consistency of continuous scales was assessed using the entire Wave 2 NESARC. Both test and retest interviews were conducted face-to-face. Test-retest and internal consistency results for diagnoses and symptom scales associated with posttraumatic stress disorder, attention-deficit/hyperactivity disorder, and borderline, narcissistic, and schizotypal personality disorders were predominantly good (kappa>0.63; ICC>0.69; alpha>0.75) and reliability for risk factor measures fell within the good to excellent range (intraclass correlations=0.50-0.94; alpha=0.64-0.90). The high degree of reliability found in this study suggests that new AUDADIS-IV diagnostic measures can be useful tools in research settings. The availability of highly reliable measures of risk factors for alcohol, drug, and psychiatric disorders will contribute to the validity of conclusions drawn from future research in the domains of substance use disorder and psychiatric epidemiology. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Ruan, W June AU - Goldstein, Rise B AU - Chou, S Patricia AU - Smith, Sharon M AU - Saha, Tulshi D AU - Pickering, Roger P AU - Dawson, Deborah A AU - Huang, Boji AU - Stinson, Frederick S AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, United States Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 27 EP - 36 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 92 IS - 1-3 SN - 0376-8716, 0376-8716 KW - Reliability KW - Alcohol and drug use disorders KW - Risk factors KW - Test-retest reliability KW - General population KW - Internal consistency KW - Diagnostic testing KW - Test-Retest reliability KW - Psychiatric disorders KW - Alcohol related disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57229447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=The+Alcohol+Use+Disorder+and+Associated+Disabilities+Interview+Schedule-IV+%28AUDADIS-IV%29%3A+Reliability+of+new+psychiatric+diagnostic+modules+and+risk+factors+in+a+general+population+sample&rft.au=Ruan%2C+W+June%3BGoldstein%2C+Rise+B%3BChou%2C+S+Patricia%3BSmith%2C+Sharon+M%3BSaha%2C+Tulshi+D%3BPickering%2C+Roger+P%3BDawson%2C+Deborah+A%3BHuang%2C+Boji%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Ruan&rft.aufirst=W&rft.date=2008-01-01&rft.volume=92&rft.issue=1-3&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.06.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Diagnostic testing; Reliability; Psychiatric disorders; Alcohol related disorders; Risk factors; Test-Retest reliability DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.06.001 ER - TY - JOUR T1 - Reinforcing coal mine roof with polyurethane injection; 4 case studies AN - 50539003; 2009-006474 JF - Geotechnical and Geological Engineering AU - Molinda, Gregory Y1 - 2008 PY - 2008 DA - 2008 SP - 553 EP - 566 PB - Springer, Dordrecht VL - 26 IS - 5 SN - 0960-3182, 0960-3182 KW - United States KW - mining KW - mines KW - underground mining KW - roof control KW - video methods KW - reinforced materials KW - rock mechanics KW - case studies KW - sedimentary rocks KW - mining geology KW - coal KW - West Virginia KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50539003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geotechnical+and+Geological+Engineering&rft.atitle=Reinforcing+coal+mine+roof+with+polyurethane+injection%3B+4+case+studies&rft.au=Molinda%2C+Gregory&rft.aulast=Molinda&rft.aufirst=Gregory&rft.date=2008-01-01&rft.volume=26&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Geotechnical+and+Geological+Engineering&rft.issn=09603182&rft_id=info:doi/10.1007%2Fs10706-008-9189-0 L2 - http://www.springerlink.com/app/home/journal.asp?wasp=f656ca91cf3b40e8868983de406060e5&referrer=parent&backto=linkingpublicationresults,1:100171,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - case studies; coal; mines; mining; mining geology; reinforced materials; rock mechanics; roof control; sedimentary rocks; underground mining; United States; video methods; West Virginia DO - http://dx.doi.org/10.1007/s10706-008-9189-0 ER - TY - JOUR T1 - Projecting long term medical spending growth AN - 36794457; 3491073 AB - We present a dynamic general equilibrium model of the U.S. economy and the medical sector in which the adoption of new medical treatments is endogenous and the demand for medical services is conditional on the state of technology. We use this model to prepare 75-year medical spending forecasts and a projection of the Medicare actuarial balance, and we compare our results to those obtained from a method that has been used by government actuaries. Our baseline forecast predicts slower health spending growth in the long run and a lower Medicare actuarial deficit relative to the previous projection methodology. All rights reserved, Elsevier JF - Journal of health economics AU - Borger, C AU - Rutherford, T F AU - Won, Gregory Y AD - US Department of Health and Human Services Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 69 EP - 88 VL - 27 IS - 1 SN - 0167-6296, 0167-6296 KW - Economics KW - Medicare KW - Medical care KW - Public expenditure KW - Economic forecasts KW - Health policy KW - General economic equilibrium KW - U.S.A. UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36794457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+economics&rft.atitle=Projecting+long+term+medical+spending+growth&rft.au=Borger%2C+C%3BRutherford%2C+T+F%3BWon%2C+Gregory+Y&rft.aulast=Borger&rft.aufirst=C&rft.date=2008-01-01&rft.volume=27&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+economics&rft.issn=01676296&rft_id=info:doi/10.1016%2Fj.jhealeco.2007.03.003 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3937 5163; 5788 11888 10472; 5436 4375; 7875 5775 13521; 10443 4618; 433 293 14 DO - http://dx.doi.org/10.1016/j.jhealeco.2007.03.003 ER - TY - JOUR T1 - Emerging Enteric and Potentially Waterborne Pathogens AN - 21241382; 11188379 AB - Infectious water-borne pathogens are a major cause of morbidity and mortality. A substantial proportion of water-borne disease is caused by established pathogens. However, emerging pathogens present important challenges to the water and health sectors. The last 30 to 40 years has seen the initial identification of a number of significant pathogens that can be water-borne including rotavirus, norovirus, V.cholerae 0139, Cryptosporidium, Campylobacter and Legionella. Many more are classified as emerging due to detection of increased incidence of disease or detection in areas where they were not previously established. The emergence of infectious diseases, including those that are water-borne, is caused by a number of factors such as population growth, migration, travel, new environments, climate change, improved methodology and drug resistance. Understanding these factors is an important component of establishing effective management of water resources and drinking water safety plans. JF - Water Practice and Technology AU - Cunliffe, DA AD - Public Health Service, Department of Health, PO Box 6, Rundle Mall, South Australia 5001, david.cunime@health.sa.gov.au Y1 - 2008 PY - 2008 DA - 2008 VL - 3 IS - 4 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Aqualine Abstracts; Water Resources Abstracts KW - Rotavirus KW - Travel KW - Population growth KW - Drug resistance KW - Viruses KW - Climatic changes KW - Water resources KW - Migration KW - Morbidity KW - Drinking Water KW - Infectious diseases KW - Water-borne diseases KW - Climatic Changes KW - Diseases KW - Legionella KW - Mortality KW - Campylobacter KW - Norovirus KW - Pathogens KW - Cryptosporidium KW - Drinking water KW - AQ 00001:Water Resources and Supplies KW - V 22300:Methods KW - SW 0810:General KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21241382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Practice+and+Technology&rft.atitle=Emerging+Enteric+and+Potentially+Waterborne+Pathogens&rft.au=Cunliffe%2C+DA&rft.aulast=Cunliffe&rft.aufirst=DA&rft.date=2008-01-01&rft.volume=3&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Water+Practice+and+Technology&rft.issn=&rft_id=info:doi/10.2166%2Fwpt.2008.092 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Travel; Mortality; Infectious diseases; Drug resistance; Population growth; Climatic changes; Water-borne diseases; Water resources; Pathogens; Drinking water; Migration; Morbidity; Drinking Water; Viruses; Cryptosporidium; Climatic Changes; Diseases; Rotavirus; Campylobacter; Norovirus; Legionella DO - http://dx.doi.org/10.2166/wpt.2008.092 ER - TY - BOOK T1 - Effects of Microbiota on GI Health: Gnotobiotic Research AN - 21239439; 11277202 AB - The complex interactions between the GI tract microbiota and the immune system can be simplified for study using gnotobiotic animal models. The importance of cytokines, such as IFN-*g, TNF-*a, TGF-*b, Interleukin-2, IL-4 and IL-10 in the host response to intestinal bacteria has been evaluated using gnotobiotic studies. Gnotobiotic experiments with immunodeficient animals have revealed insights into the relationships between innate, cell-mediated and antibody-mediated immune system components in resistance to infectious microorganisms. The development and maturation of the immune system is dependent on the presence of some members of the intestinal microbiota. The commensal microorganisms, in turn, are dependent on the environment and nutrients provided by the GI tract of the host. Gnotobiotic studies are starting to reveal how the microbiota influences oral tolerance to dietary and commensal bacterial antigens. The immunomodulatory effects of microbiota and probiotics for inflammatory bowel diseases and the role of bacteria in their etiologies are being studied in gnotobiotic systems. Many aspects of the host interaction with the microbiota have been and will continue to be best addressed in gnotobiotic experimental models. This chapter reviews the contributions that gnotobiology has made to our understanding of the microbiota and host GI tract health. JF - Advances in Experimental Medicine and Biology AU - Wagner, Robert Doug A2 - Huffnagle, Gary B A2 - Noverr, Mairi C (Eds) Y1 - 2008 PY - 2008 DA - 2008 SP - 16 EP - 56 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany SN - 9780387799896 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Interleukin 4 KW - Etiology KW - Interleukin 2 KW - Immune system KW - Immunodeficiency KW - Animal models KW - probiotics KW - Commensals KW - Nutrients KW - Immunomodulation KW - Immunological tolerance KW - Interleukin 10 KW - Oral cavity KW - Intestinal microflora KW - Inflammatory bowel diseases KW - Microorganisms KW - Gnotobiotics KW - Intestine KW - Gastrointestinal tract KW - A 01330:Food Microbiology KW - J 02350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21239439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Bacteriology+Abstracts+%28Microbiology+B%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Wagner%2C+Robert+Doug&rft.aulast=Wagner&rft.aufirst=Robert&rft.date=2008-01-01&rft.volume=&rft.issue=&rft.spage=41&rft.isbn=9780387799896&rft.btitle=Effects+of+Microbiota+on+GI+Health%3A+Gnotobiotic+Research&rft.title=Effects+of+Microbiota+on+GI+Health%3A+Gnotobiotic+Research&rft.issn=00652598&rft_id=info:doi/10.1007%2F978-0-387-09550-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 DO - http://dx.doi.org/10.1007/978-0-387-09550-9 ER - TY - JOUR T1 - Heteroresistance to vancomycin and novel point mutations in Tn1546 of Enterococcus faecium ATCC 51559 AN - 21043404; 8580666 AB - A clinical strain of Enterococcus faecium ATCC 51559 exhibits heteroresistance, i.e. a high level of resistance to vancomycin (minimum inhibitory concentration (MIC) > 256 kg/mL) by broth dilution but sensitivity to vancomycin by Etest (MIC = 1.8 kg/mL). Three variants of this strain, EF1, EF2 and EF3, exhibit high levels of resistance to vancomycin both by broth dilution and Etest assays. The four strains were used to study heteroresistance by pulsed-field gel electrophoresis (PFGE), polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP) and sequence analysis of a partial region of the van operon. Minor differences between SalI and SmaI restriction profiles of the variants and the parental strain were observed by PFGE analysis. PCR analysis confirmed the presence of the vancomycin resistance marker vanA (0.73 kb) and a larger than expected amplicon (8.2 kb vs. 6.7 kb) of the van operon in all the strains. The 8.2 kb van operon was cloned for EcoRI RFLP and sequence analysis. All of the clones exhibited distinctly different RFLP profiles when grown in the presence of kanamycin or vancomycin + kanamycin. The presence of these antibiotics during overnight growth of EF1 on plates also resulted in altered SalI PFGE profiles. Sequence analysis of the van operon clones revealed a 1.5 kb IS1251-like insertion element between the vanS and vanH genes in all the strains. Several novel point mutations in the vanR, vanS, vanH, vanA, vanX and vanY genes were also discovered. Some of these mutations were present in the parental strain only and included base substitutions T --> C, A --> G, T --> A and T - -> C at nucleotide positions 4202, 4597, 4763 and 6207 of Tn1546, resulting in amino acid replacements I76 --> T and K208 --> E of vanR, S19 --> T of vanS and L64 --> P of vanH genes, respectively. We believe that these are responsible for the observed heteroresistance. The present study clearly shows how independent novel mutations can give rise to polymorphism, heteroresistance and clonal diversity among vancomycin- resistant enterococci strains as a result of continuous exposure to antibiotics. JF - International Journal of Antimicrobial Agents AU - Khan, Saeed A AU - Sung, Kidon AU - Layton, Sherryll AU - Nawaz, Mohamed S AD - Division of Microbiology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA, saeed.khan@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 27 EP - 36 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 31 IS - 1 SN - 0924-8579, 0924-8579 KW - Microbiology Abstracts B: Bacteriology KW - Vancomycin-resistant enterococci KW - Polymerase chain reaction KW - Restriction fragment length polymorphism KW - Pulsed-field gel electrophoresis KW - Insertion element KW - Amino acids KW - Amino acid substitution KW - Point mutation KW - Antibiotics KW - Kanamycin KW - Minimum inhibitory concentration KW - Nucleotides KW - Enterococcus faecium KW - Vancomycin KW - Operons KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21043404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Heteroresistance+to+vancomycin+and+novel+point+mutations+in+Tn1546+of+Enterococcus+faecium+ATCC+51559&rft.au=Khan%2C+Saeed+A%3BSung%2C+Kidon%3BLayton%2C+Sherryll%3BNawaz%2C+Mohamed+S&rft.aulast=Khan&rft.aufirst=Saeed&rft.date=2008-01-01&rft.volume=31&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/10.1016%2Fj.ijantimicag.2007.08.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Amino acid substitution; Amino acids; Point mutation; Pulsed-field gel electrophoresis; Restriction fragment length polymorphism; Polymerase chain reaction; Vancomycin; Kanamycin; Antibiotics; Operons; Minimum inhibitory concentration; Nucleotides; Enterococcus faecium DO - http://dx.doi.org/10.1016/j.ijantimicag.2007.08.007 ER - TY - JOUR T1 - Application of Prevention through Design for Hearing Loss in the Mining Industry AN - 21034036; 8549653 AB - Introduction Overexposure to noise remains a widespread and serious health hazard in the U.S. service providing and goods producing industries. Excessive noise can lead to poor verbal communication and reduce the ability to recognize warning signals. These dangerous work conditions can also cause stress and fatigue. Occupational hearing loss is a permanent illness, with no recovery currently possible. Method National Institute for Occupational Safety and Health (NIOSH) has recognized Noise Induced Hearing Loss (NIHL) as one of the ten leading work-related diseases and injuries in the United States, and has emphasized its importance as one of the critical areas expressed in the National Occupational Research Agenda. Results One of the most serious noise problems in the goods producing industries is the operation of continuous mining machines during underground coal mining. In order to minimize occupational hearing loss, noise hazards are 'designed out' early in the design process. NIOSH is leading a national initiative called Prevention through Design (PTD) to promote this concept. This paper describes the quiet-by-design approach of a noise control that reduced noise exposures of continuous mining machine operators by 3dB(A) using the four functional areas of PTD, namely Practice, Policy, Research, and Education. JF - Journal of Safety Research AU - Kovalchik, Peter G AU - Matetic, Rudy J AU - Smith, Adam K AU - Bealko, Susan B AD - National Institute for Occupational Safety and Health, PKovalchik@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 251 EP - 254 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 2 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - Occupational safety KW - Noise reduction KW - Coal KW - fatigue KW - prevention KW - policy research KW - Noise levels KW - Stress KW - Hearing loss KW - Design KW - Education KW - USA KW - Communications KW - Mining KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21034036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Application+of+Prevention+through+Design+for+Hearing+Loss+in+the+Mining+Industry&rft.au=Kovalchik%2C+Peter+G%3BMatetic%2C+Rudy+J%3BSmith%2C+Adam+K%3BBealko%2C+Susan+B&rft.aulast=Kovalchik&rft.aufirst=Peter&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Noise levels; Hearing loss; Mining; Noise reduction; prevention; Communications; Design; Coal; Education; Stress; Occupational safety; policy research; fatigue DO - http://dx.doi.org/10.1016/j.jsr.2008.02.029 ER - TY - JOUR T1 - Problems of groundwater management and the need for its inclusion in the Brazilian national model of integrated water resources management AN - 21021577; 8190738 AB - This paper discusses certain issues related to groundwater management within the context of the Brazilian national policy for water resources management. In order to investigate the importance of this water supply source, we interviewed groundwater users in the city of Sao Paulo, where some 57% of the total water supply comes from this source, and surveyed some of the factors affecting the use of this alternative. These include the existence of a good supply of groundwater, an inadequate public water supply system unable to meet user demands, the degradation of fresh water sources and the reduction in costs involved. Preliminary conclusions suggest the inadequacy of the present system of water resources management, which has not yet integrated the use of groundwater reserves into an overall national program for water resources management. JF - Water Policy AU - Rodrigues, FdA AU - Pereira, SY AD - Department of Geology and Natural Resources, State University of Campinas, 51 Pandia Calogeras, Campinas, SP, P.A. 13083 - 970, Brazil, assis@ige.unicamp.br Y1 - 2008 PY - 2008 DA - 2008 SP - 165 EP - 171 VL - 10 IS - 2 SN - 1366-7017, 1366-7017 KW - Pollution Abstracts; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Water Resources Abstracts KW - Degradation KW - Water Costs KW - Groundwater management KW - Water Supply KW - Water resources KW - Public Waters KW - Water Resources Management KW - Water supplies KW - Potential resources KW - Water Policy KW - Ground water KW - Water sources KW - Groundwater Management KW - Urban areas KW - Modelling KW - water policy KW - Water resources management KW - Policies KW - Model Studies KW - Water supply KW - Brazil, Sao Paulo KW - Water management KW - Groundwater KW - Water policy KW - Q2 09122:Legislation KW - P 2000:FRESHWATER POLLUTION KW - M3 1010:Issues in Sustainable Development KW - M2 556.18:Water Management (556.18) KW - SW 3020:Sources and fate of pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21021577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Policy&rft.atitle=Problems+of+groundwater+management+and+the+need+for+its+inclusion+in+the+Brazilian+national+model+of+integrated+water+resources+management&rft.au=Rodrigues%2C+FdA%3BPereira%2C+SY&rft.aulast=Rodrigues&rft.aufirst=FdA&rft.date=2008-01-01&rft.volume=10&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Water+Policy&rft.issn=13667017&rft_id=info:doi/10.2166%2Fwp.2008.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Policies; Potential resources; Water management; Ground water; Water resources; Modelling; Water policy; Water supply; Water resources management; Groundwater management; Water sources; water policy; Degradation; Groundwater; Water supplies; Urban areas; Water Policy; Water Costs; Water Supply; Public Waters; Water Resources Management; Groundwater Management; Model Studies; Brazil, Sao Paulo DO - http://dx.doi.org/10.2166/wp.2008.038 ER - TY - JOUR T1 - Reducing Commercial Fishing Deck Hazards with Engineering Solutions for Winch Design AN - 21020455; 8549651 AB - Introduction The majority (67%) of hospitalized injuries among Alaska commercial fishermen are associated with deck machinery. This paper describes the 'Prevention Through Design' process to mitigate one serious machinery entanglement hazard posed by a capstan deck winch. Methods After observing that the capstan winch provides no entanglement protection and the hydraulic controls are usually out of reach of the entangled person, NIOSH personnel met with fishermen and winch manufacturers to discuss various design solutions to mitigate these hazards. Results An emergency-stop ('e-stop') system was developed that incorporated a momentary contact button that when pushed, switches a safety-relay that de-energizes the solenoid of an electro-hydraulic valve stopping the rotating winch. The vessel owners that had the e-stop installed enthusiastically recommend it to other fishermen. NIOSH entered into a Proprietary Technology Licensing Agreement with a company to develop the system for commercial use. Conclusions This is an example of a practical engineering control that effectively protects workers from a hazardous piece of equipment by preventing injuries due to entanglement. This solution could reduce these types of debilitating injuries and fatalities in this industry. JF - Journal of Safety Research AU - Lincoln, Jennifer M AU - Lucas, Devin L AU - McKibbin, Robert W AU - Woodward, Chelsea C AU - Bevan, John E AD - NIOSH Alaska Field Station, Anchorage Alaska, jlincoln@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 231 EP - 235 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 2 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - Hydraulics KW - Injuries KW - Occupational safety KW - Licensing KW - Hazards KW - Commercial fishing KW - Machinery KW - prevention KW - USA, Alaska KW - Mortality KW - Design KW - safety engineering KW - Technology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21020455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Reducing+Commercial+Fishing+Deck+Hazards+with+Engineering+Solutions+for+Winch+Design&rft.au=Lincoln%2C+Jennifer+M%3BLucas%2C+Devin+L%3BMcKibbin%2C+Robert+W%3BWoodward%2C+Chelsea+C%3BBevan%2C+John+E&rft.aulast=Lincoln&rft.aufirst=Jennifer&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Alaska; Injuries; Machinery; safety engineering; Design; Licensing; Mortality; Commercial fishing; Hydraulics; prevention; Technology; Occupational safety; Hazards DO - http://dx.doi.org/10.1016/j.jsr.2008.02.027 ER - TY - JOUR T1 - McCune-Albright syndrome AN - 20999332; 8819346 AB - McCune-Albright syndrome (MAS) is classically defined by the clinical triad of fibrous dysplasia of bone (FD), cafe-au-lait skin spots, and precocious puberty (PP). It is a rare disease with estimated prevalence between 1/100,000 and 1/1,000,000. FD can involve a single or multiple skeletal sites and presents with a limp and/or pain, and, occasionally, a pathologic fracture. Scoliosis is common and may be progressive. In addition to PP (vaginal bleeding or spotting and development of breast tissue in girls, testicular and penile enlargement and precocious sexual behavior in boys), other hyperfunctioning endocrinopathies may be involved including hyperthyroidism, growth hormone excess, Cushing syndrome, and renal phosphate wasting. Cafe-au-lait spots usually appear in the neonatal period, but it is most often PP or FD that brings the child to medical attention. Renal involvement is seen in approximately 50% of the patients with MAS. The disease results from somatic mutations of the GNAS gene, specifically mutations in the cAMP regulating protein, G sub(s )alpha. The extent of the disease is determined by the proliferation, migration and survival of the cell in which the mutation spontaneously occurs during embryonic development. Diagnosis of MAS is usually established on clinical grounds. Plain radiographs are often sufficient to make the diagnosis of FD and biopsy of FD lesions can confirm the diagnosis. The evaluation of patients with MAS should be guided by knowledge of the spectrum of tissues that may be involved, with specific testing for each. Genetic testing is possible, but is not routinely available. Genetic counseling, however, should be offered. Differential diagnoses include neurofibromatosis, osteofibrous dysplasia, non-ossifying fibromas, idiopathic central precocious puberty, and ovarian neoplasm. Treatment is dictated by the tissues affected, and the extent to which they are affected. Generally, some form of surgical intervention is recommended. Bisphosphonates are frequently used in the treatment of FD. Strengthening exercises are recommended to help maintaining the musculature around the FD bone and minimize the risk for fracture. Treatment of all endocrinopathies is required. Malignancies associated with MAS are distinctly rare occurrences. Malignant transformation of FD lesions occurs in probably less than 1% of the cases of MAS. JF - Orphanet Journal of Rare Diseases AU - Dumitrescu, Claudia E AU - Collins, Michael T AD - Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, mosteanuc@nidcr.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 12 PB - BioMed Central Ltd., Middlesex House VL - 3 SN - 1750-1172, 1750-1172 KW - Risk Abstracts KW - sexual behavior KW - pain KW - Hormones KW - surgery KW - risk reduction KW - genetic screening KW - intervention KW - enlargement KW - Lesions KW - plains KW - migration KW - Skin KW - Bone KW - Phosphates KW - Proteins KW - Neonates KW - survival KW - Mutation KW - bisphosphonates KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20999332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Orphanet+Journal+of+Rare+Diseases&rft.atitle=McCune-Albright+syndrome&rft.au=Dumitrescu%2C+Claudia+E%3BCollins%2C+Michael+T&rft.aulast=Dumitrescu&rft.aufirst=Claudia&rft.date=2008-01-01&rft.volume=3&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Orphanet+Journal+of+Rare+Diseases&rft.issn=17501172&rft_id=info:doi/10.1186%2F1750-1172-3-12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mutation; genetic screening; Bone; Lesions; sexual behavior; Phosphates; risk reduction; Hormones; enlargement; intervention; bisphosphonates; surgery; pain; survival; migration; Proteins; plains; Skin; Neonates DO - http://dx.doi.org/10.1186/1750-1172-3-12 ER - TY - JOUR T1 - Effects of Stratification on Data Mining in the US Vaccine Adverse Event Reporting System (VAERS) AN - 20978856; 8540473 AB - Background: Vaccines are administered differentially according to age and sex, and disease patterns also vary among people of different age and sex groups. Estimates of disproportionality should be calculated based on comparisons of groups that have a similar likelihood of receiving similar vaccines and experiencing similar adverse events, to prevent false disproportionality from occurring. Stratified empirical Bayesian (EB) methods have been compared with crude, but not stratified, proportional reporting ratios (PRRs) in their performance on adverse event data. Objectives: (i) to implement stratification of PRR; (ii) to quantify and compare vaccine-event pairs that are highlighted by PRR and EB05 (the lower bound of the 90% CI of the EB geometric mean), for both crude and stratified; and (iii) to evaluate the effects of stratification by age and sex, in identifying adverse events that are accepted to be caused by vaccines. Methods: We applied EB and PRR data mining methods to data from the US Vaccine Adverse Event Reporting System (VAERS). We stratified PRR and EB05 by age and sex. To study the effects of stratification, we compared the crude PRR and stratified PRR. We also assessed the crude EB05 and stratified EB05, and then compared the effects of stratification on EB05 and PRR. Results: Stratification not only changed the number of vaccine-event pairs that were highlighted, but also changed which pairs were highlighted. There were 283 vaccine-event pairs that were highlighted by the crude EB05, but not the stratified; 12 that were highlighted by the stratified EB05, but not the crude; and 162 that were highlighted by both. Similarly, there were 701 vaccine-event pairs that were highlighted by the crude PRR, but not the stratified; 139 that were highlighted by the stratified PRR, but not the crude; and 895 that were highlighted by both. There were 1466 vaccine-event pairs in which the effect of stratification was different for EB05 and PRR. Conclusion: To our knowledge, this is the first published analysis using stratified PRRs. In this analysis of passive surveillance data, stratification revealed and reduced confounding in EB and PRR, and also unmasked some vaccine-event pairs that the crude values did not highlight. Stratification should be applied if confounding is suspected. By decreasing the total number of highlighted vaccine-event pairs, stratification is likely to increase efficiency and therefore might reduce workload. JF - Drug Safety AU - Emily Jane Woo, AU - Ball, Robert AU - Burwen, Dale R AU - Braun, MMiles AD - US Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, Maryland, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 667 EP - 674 PB - Adis International Inc., [URL:http://www.adis.com] VL - 31 IS - 8 SN - 0114-5916, 0114-5916 KW - Health & Safety Science Abstracts KW - Adverse drug reactions KW - Adverse reaction monitoring KW - Data collection KW - Postmarketing surveillance KW - Vaccines KW - age groups KW - USA KW - vaccines KW - Age KW - Stratification KW - Drugs KW - Side effects KW - working conditions KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20978856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Safety&rft.atitle=Effects+of+Stratification+on+Data+Mining+in+the+US+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29&rft.au=Emily+Jane+Woo%2C%3BBall%2C+Robert%3BBurwen%2C+Dale+R%3BBraun%2C+MMiles&rft.aulast=Emily+Jane+Woo&rft.aufirst=&rft.date=2008-01-01&rft.volume=31&rft.issue=8&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Drug+Safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - age groups; Age; Data collection; vaccines; Stratification; Drugs; working conditions; Side effects; USA ER - TY - JOUR T1 - Intervention Effectiveness Evaluation Criteria: Promoting Competitions and Raising the Bar AN - 20978282; 8549422 AB - The Intervention Evaluation Competition at the Work, Stress, and Health conference in Miami (March 2006) highlighted the importance of intervention evaluation studies that promote safety and health at work. A retitled, 'Best Practices Evaluation Competition,' has been included in the March, 2008, Work, Stress, and Health conference, in Washington, DC. This brief note describes the development of the criteria used to evaluate the manuscripts. The criteria are discussed with respect to (a) improving the science of evaluation methodology, (b) promoting the highest ethical standards in intervention evaluation, and (c) using the current criteria as a starting point for continuing to raise the bar for evaluation methodology. The policy implications of the evaluation criteria are discussed as well. JF - Journal of Occupational Health Psychology AU - Scharf, Ted AU - Chapman, Larry AU - Collins, Jim AU - Limanowski, Julia AU - Heaney, Cathy AU - Goldenhar, Linda M AD - Division of Applied Research and Technology, NIOSH, Cincinnati, Ohio, tscharf@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 1 EP - 9 PB - American Psychological Association, 750 First St., N.E. Washington DC 20002-4242 USA, [mailto:journals@apa.org], [URL:http://www.apa.org/] VL - 13 IS - 1 SN - 1076-8998, 1076-8998 KW - Health & Safety Science Abstracts KW - Conferences KW - Occupational safety KW - Stress KW - best practices KW - Ethics KW - intervention KW - USA, Florida, Miami KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20978282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+Health+Psychology&rft.atitle=Intervention+Effectiveness+Evaluation+Criteria%3A+Promoting+Competitions+and+Raising+the+Bar&rft.au=Scharf%2C+Ted%3BChapman%2C+Larry%3BCollins%2C+Jim%3BLimanowski%2C+Julia%3BHeaney%2C+Cathy%3BGoldenhar%2C+Linda+M&rft.aulast=Scharf&rft.aufirst=Ted&rft.date=2008-01-01&rft.volume=13&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Health+Psychology&rft.issn=10768998&rft_id=info:doi/10.1037%2F1076-8998.13.1.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Florida, Miami; intervention; Occupational health; Stress; Conferences; best practices; Occupational safety; Ethics DO - http://dx.doi.org/10.1037/1076-8998.13.1.1 ER - TY - JOUR T1 - Prevention through Design - Introduction AN - 20975050; 8549623 AB - Abstract not available. JF - Journal of Safety Research AU - Howard, John AD - Director, National Institute for Occupational Safety and Health, jhoward1@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 113 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 2 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20975050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Prevention+through+Design+-+Introduction&rft.au=Howard%2C+John&rft.aulast=Howard&rft.aufirst=John&rft.date=2008-01-01&rft.volume=39&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.02.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.jsr.2008.02.022 ER - TY - RPRT T1 - A Tree Trimmer Dies When He is Pulled into a Wood Chipper AN - 20967607; 11069910 AB - A Hispanic male tree trimmer died after he was pulled into a wood chipper while feeding branches into the machine. The victim was part of a two-man crew that was trimming trees along a residential street when the incident occurred. The wood chipper had a built-in safety device called the feed control bar that was located on the top and both sides of the feed chute, however it is not known if it was working at the time of the incident. The CA/FACE investigator determined that, in order to prevent future occurrences, employers, as part of their Injury and Illness Prevention Program (IIPP), should: Ensure that employees never operate a wood chipper alone. Ensure that all employees stand to the side of the feed table when feeding trimmings into the wood chipper. Ensure that employees are thoroughly trained and tested on the operation of wood chippers. Ensure that a documented inspection report is completed every time a wood chipper is used and kept on file. JF - A Tree Trimmer Dies When He is Pulled into a Wood Chipper. [np]. 2008. AU - Anonymous Y1 - 2008 PY - 2008 DA - 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Trees KW - feeding KW - Wood KW - inspection KW - prevention KW - Ethnic groups KW - Feeds KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Tree+Trimmer+Dies+When+He+is+Pulled+into+a+Wood+Chipper&rft.title=A+Tree+Trimmer+Dies+When+He+is+Pulled+into+a+Wood+Chipper&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - A biocompatible medium for nanoparticle dispersion AN - 20944856; 8493288 AB - Our laboratory has reported that rat bronchoalveolar lavage (BAL) fluid is an effective nanoparticle (NP) dispersant. However, its utility is constrained by its cost and the lack of standardization to control for intra- and inter-laboratory variability in BAL fluid. In this study, we report the efficacy and biocompatibility of a dispersion medium (DM), which is a 'lung fluid mimic'. In vitro studies, which used dynamic light scattering and transmission electron microscopy, determined that ultrafine titanium dioxide and ultrafine carbon black are equally well dispersed by DM or BAL fluid. We also determined that DM was effective at dispersing multi-walled carbon nanotubes. In vivo, when used as a vehicle, DM per se did not elicit toxicity and did not influence or alter toxic responses to crystalline silica in either the lung or brain. Overall, these studies indicate that DM is an effective, biocompatible, and economical vehicle for nanotoxicological studies. JF - Nanotoxicology AU - Porter, D AU - Sriram, K AU - Wolfarth, M AU - Jefferson, A AU - Schwegler-Berry, D AU - Andrew, ME AU - Castranova, V AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 144 EP - 154 VL - 2 IS - 3 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Biocompatibility KW - Transmission electron microscopy KW - Brain KW - Light scattering KW - Toxicity KW - Dispersants KW - Alveoli KW - Standardization KW - Titanium dioxide KW - Silica KW - Carbon KW - Bronchus KW - Lung KW - nanotubes KW - nanoparticles KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20944856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=A+biocompatible+medium+for+nanoparticle+dispersion&rft.au=Porter%2C+D%3BSriram%2C+K%3BWolfarth%2C+M%3BJefferson%2C+A%3BSchwegler-Berry%2C+D%3BAndrew%2C+ME%3BCastranova%2C+V&rft.aulast=Porter&rft.aufirst=D&rft.date=2008-01-01&rft.volume=2&rft.issue=3&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.1080%2F17435390802318349 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Biocompatibility; Transmission electron microscopy; Light scattering; Brain; Toxicity; Dispersants; Alveoli; Standardization; Carbon; Silica; Titanium dioxide; Bronchus; Lung; nanotubes; nanoparticles DO - http://dx.doi.org/10.1080/17435390802318349 ER - TY - JOUR T1 - A regulatory viewpoint on transporter-based drug interactions AN - 20937743; 8493298 AB - 1. Pharmacokinetic drug interactions can lead to serious adverse events and the evaluation of a new molecular entity's (NME) drug-drug interaction potential is an integral part of drug development and regulatory review before its market approval. Clinically relevant interactions mediated by transporters are of increasing interest in clinical development and research in this emerging area and it has been revealed that drug transporters can play an important role in modulating drug absorption, distribution, metabolism and elimination. 2. Acting alone or in concert with drug-metabolizing enzymes transporters can affect the pharmacokinetics and/or pharmacodynamics of a drug. The newly released drug interaction guidance by the US Food and Drug Administration (USFDA) includes new information addressing drug transporter interactions with a primary focus on P-glycoprotein (P-gp, ABCB1). 3. This paper provides a regulatory viewpoint on transporters and their potential role in drug-drug interactions. It first outlines information that might be needed during drug development and ultimately included in new drug application (NDA) submissions to address potential transporter-mediated drug interactions. Next, it explains criteria that may warrant conduct of in vivo P-gp-mediated drug interaction studies based on in vitro assessment. In addition, it includes a review case that describes the evaluation of data suggesting a P-gp-based induction interaction. JF - Xenobiotica AU - Zhang, L AU - Zhang, Y AU - Strong, J M AU - Reynolds, K S AU - Huang, S-M AD - Offices of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 709 EP - 724 VL - 38 IS - 7/8 SN - 0049-8254, 0049-8254 KW - Toxicology Abstracts KW - Drug interaction KW - P-Glycoprotein KW - Data processing KW - Reviews KW - Drug metabolism KW - Enzymes KW - Drug development KW - Pharmacokinetics KW - Pharmacodynamics KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20937743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica&rft.atitle=A+regulatory+viewpoint+on+transporter-based+drug+interactions&rft.au=Zhang%2C+L%3BZhang%2C+Y%3BStrong%2C+J+M%3BReynolds%2C+K+S%3BHuang%2C+S-M&rft.aulast=Zhang&rft.aufirst=L&rft.date=2008-01-01&rft.volume=38&rft.issue=7%2F8&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Xenobiotica&rft.issn=00498254&rft_id=info:doi/10.1080%2F00498250802017715 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drug interaction; P-Glycoprotein; Data processing; Drug metabolism; Reviews; Enzymes; Drug development; Pharmacodynamics; Pharmacokinetics DO - http://dx.doi.org/10.1080/00498250802017715 ER - TY - JOUR T1 - Crystalline Silica is a Negative Modifier of Pulmonary Cytochrome P-4501A1 Induction AN - 20929287; 8173930 AB - Polycyclic aromatic hydrocarbons (PAHs) are products of incomplete combustion that are commonly inhaled by workers in the dusty trades. Many PAHs are metabolized by cytochrome P-4501A1 (CYP1A1), which may facilitate excretion but may activate pulmonary carcinogens. PAHs also stimulate their own metabolism by inducing CYP1A1. Recent studies suggest that respirable coal dust exposure inhibits induction of pulmonary CYP1A1 using the model PAH beta -naphthoflavone. The effect of the occupational particulate respirable crystalline silica was investigated on PAH-dependent pulmonary CYP1A1 induction. Male Sprague-Dawley rats were exposed to intratracheal silica or vehicle and then intraperitoneal beta -naphthoflavone, a CYP1A1 inducer, and/or phenobarbital, an inducer of hepatic CYP2B1, or vehicle. beta -Naphthoflavone induced pulmonary CYP1A1, but silica attenuated this beta -naphthoflavone-induced CYP1A1 activity and also suppressed the activity of CYP2B1, the major constitutive CYP in rat lung. The magnitude of CYP activity suppression was similar regardless of silica exposure dose within a range of 5 to 20 mg/rat. Phenobarbital and beta -naphthoflavone had no effect on pulmonary CYP2B1 activity. Both enzymatic immunohistochemistry and immunofluorescent staining for CYP1A1 indicated that sites of CYP1A1 induction were nonciliated airway epithelial cells, endothelial cells, and the alveolar septum. Using immunofluorescent colocalization of CYP1A1 with cytokeratin 8, a marker of alveolar type II cells, the proximal alveolar region was the site of both increased alveolar type II cells and decreased proportional CYP1A1 expression in alveolar type II cells. Our findings suggest that in PAH-exposed rat lung, silica is a negative modifier of CYP1A1 induction and CYP2B1 activity. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Battelli, LA AU - Ghanem, M M AU - Kashon, M L AU - Barger, M AU - Ma, JYC AU - Simoskevitz, R L AU - Miles, PR AU - Hubbs, A F AD - CDC/NIOSH, 1095 Willowdale Road, M/S L2015, Morgantown, WV 26505, USA, LBattelli@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 521 EP - 532 VL - 71 IS - 7-8 SN - 1528-7394, 1528-7394 KW - Toxicology Abstracts KW - Epithelial cells KW - Cytochromes KW - Phenobarbital KW - Polycyclic aromatic hydrocarbons KW - Carcinogens KW - Alveoli KW - Combustion KW - Endothelial cells KW - Workers KW - beta -Naphthoflavone KW - Silica KW - Lung KW - Liver KW - Excretion KW - Coal dust KW - Cytochrome P450 KW - Septum KW - Trachea KW - Immunohistochemistry KW - Metabolism KW - Cytokeratin KW - Respiratory tract KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20929287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Crystalline+Silica+is+a+Negative+Modifier+of+Pulmonary+Cytochrome+P-4501A1+Induction&rft.au=Battelli%2C+LA%3BGhanem%2C+M+M%3BKashon%2C+M+L%3BBarger%2C+M%3BMa%2C+JYC%3BSimoskevitz%2C+R+L%3BMiles%2C+PR%3BHubbs%2C+A+F&rft.aulast=Battelli&rft.aufirst=LA&rft.date=2008-01-01&rft.volume=71&rft.issue=7-8&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390801907483 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cytochromes; Epithelial cells; Polycyclic aromatic hydrocarbons; Phenobarbital; Carcinogens; Alveoli; Combustion; Endothelial cells; Workers; Silica; beta -Naphthoflavone; Lung; Liver; Coal dust; Excretion; Septum; Cytochrome P450; Immunohistochemistry; Trachea; Metabolism; Respiratory tract; Cytokeratin DO - http://dx.doi.org/10.1080/15287390801907483 ER - TY - JOUR T1 - Embryonic Stem Cells Cultured in Serum-Free Medium Acquire Bovine Apolipoprotein B-100 from Feeder Cell Layers and Serum Replacement Medium AN - 20927458; 8043025 AB - Previous studies have demonstrated that cell populations that are cultured with heterologous animal products can acquire xenoantigens, potentially limiting their clinical utility because of immune responses. Embryonic stem cells (ESCs) are an attractive source of multiple potential cellular therapies and are typically derived and routinely cultured on murine embryonic fibroblast (MEF) feeder cell layers in commercially available serum replacement (SR) medium or fetal calf serum (FCS)-containing medium. Recently, we found that a strong antibody response was generated in human subjects after the second infusion of therapeutic cells cultured in FCS-containing medium. This response was specific for bovine apolipoprotein B-100 (apoB-100), which is the major protein component of low-density lipoproteins (LDL) and which targets its binding to abundant low-density lipoprotein receptors on the cell surface, from which it is internalized. Here, we have shown that ESCs cultured on MEFs in SR medium acquired bovine apoB-100 from MEFs and from the SR medium as well. Our findings also suggest that bovine LDL are used as critical nutrients for ESC propagation. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Hisamatsu-Sakamoto, Michiko AU - Sakamoto, Norihisa AU - Rosenberg, Amy S AD - Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA. Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 72 EP - 78 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 26 IS - 1 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell surface KW - Fetal calf serum KW - xenoantigens KW - Nutrients KW - lipoprotein receptors KW - Antibody response KW - Lipoproteins (low density) KW - Stem cells KW - serum-free medium KW - Embryo cells KW - Embryo fibroblasts KW - Lipoproteins KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20927458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenotransplantation&rft.atitle=National+policies+for+xenotransplantation+in+the+USA&rft.au=Bloom%2C+Eda+T&rft.aulast=Bloom&rft.aufirst=Eda&rft.date=2007-07-01&rft.volume=14&rft.issue=4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Xenotransplantation&rft.issn=0908665X&rft_id=info:doi/10.1111%2Fj.1399-3089.2007.00396.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; serum-free medium; Stem cells; Embryo cells; Fetal calf serum; Lipoproteins; xenoantigens; Embryo fibroblasts; Nutrients; Antibody response; lipoprotein receptors; Lipoproteins (low density) ER - TY - JOUR T1 - Chemical Imaging of Pharmaceutical Materials: Fabrication of Micropatterned Resolution Targets AN - 20916306; 8424022 AB - Resolution targets composed of thick poly(ethylene glycol) (PEG) lines on silicon substrates have been fabricated using the method of micromolding in capillaries (MiMIC). Patterns of three parallel lines with equal width and spacing have been prepared, with widths between 5 and 25 mu m. Raman chemical images of the PEG-on-silicon devices as well as the metal-on-glass masks used to prepare the devices were measured. The Raman images were used to determine the impulse response of the instrument by comparing the measured images to model functions prepared by convolution of a test impulse function with the object functions of the devices. Impulse widths for PEG-on-silicon targets were approximately two times greater than impulse widths for metal-on-glass targets. The results provide a quantitative measure of the influence of light-matter interactions on the spatial resolution achievable with chemical imaging instruments. This work shows that microfluidic channels can be used to produce robust patterns of PEG on silicon, and these patterns are realistic resolution targets for spectroscopic chemical imaging of pharmaceutical materials. JF - Analytical Chemistry (Washington) AU - Gilliam, Sean J AU - Martin, RScott AU - Kauffman, John F AD - Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, Food and Drug Administration, 1114 Market Street, St. Louis, Missouri 63101 Y1 - 2008 PY - 2008 DA - 2008 SP - 5706 EP - 5712 PB - American Chemical Society, Box 3337 Columbus OH 43210 USA, [mailto:service@acs.org] VL - 80 IS - 15 SN - 0003-2700, 0003-2700 KW - Biotechnology and Bioengineering Abstracts KW - Silicon KW - Microfluidics KW - Pharmaceuticals KW - spatial discrimination KW - imaging KW - Polyethylene glycol KW - Capillaries KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20916306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=Chemical+Imaging+of+Pharmaceutical+Materials%3A+Fabrication+of+Micropatterned+Resolution+Targets&rft.au=Gilliam%2C+Sean+J%3BMartin%2C+RScott%3BKauffman%2C+John+F&rft.aulast=Gilliam&rft.aufirst=Sean&rft.date=2008-01-01&rft.volume=80&rft.issue=15&rft.spage=5706&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac800864x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Microfluidics; Silicon; Pharmaceuticals; spatial discrimination; Capillaries; Polyethylene glycol; imaging; Models DO - http://dx.doi.org/10.1021/ac800864x ER - TY - JOUR T1 - Projected Cost-effectiveness of New Vaccines for Adolescents in the United States AN - 20892463; 7937049 AB - BACKGROUND. Economic assessments that guide policy making on immunizations are becoming increasingly important in light of new and anticipated vaccines for adolescents. However, important considerations that limit the utility of these assessments, such as the diversity of approaches used, are often overlooked and should be better understood. OBJECTIVE. Our goal was to examine economic studies of adolescent vaccines and compare cost-effectiveness outcomes among studies on a particular vaccine, across adolescent vaccines, and between new adolescent vaccines versus vaccines that are recommended for young children. METHODS. A systematic review of economic studies on immunizations for adolescents was conducted. Studies were identified by searching the Medline, Embase, and EconLit databases. Each study was reviewed for appropriateness of model design, baseline setup, sensitivity analyses, and input variables (ie, epidemiologic, clinical, cost, and quality-of-life impact). For comparison, the cost-effectiveness outcomes reported in key studies on vaccines for younger children were selected. RESULTS. Vaccines for healthy adolescents were consistently found to be more costly than the health care or societal cost savings they produced and, in general, were less cost-effective than vaccines for younger children. Among the new vaccines, pertussis and human papillomavirus vaccines were more cost-effective than meningococcal vaccines. Including herd-immunity benefits in studies significantly improved the cost-effectiveness estimates for new vaccines. Differences in measurements or assumptions limited further comparisons. CONCLUSION. Although using the new adolescent vaccines is unlikely to be cost-saving, vaccination programs will result in sizable health benefits. JF - Pediatrics AU - Ortega-Sanchez, Ismael R AU - Lee, Grace M AU - Jacobs, RJake AU - Prosser, Lisa A AU - Molinari, Noelle-Angelique AU - Zhang, Xinzhi AU - Baine, William B AU - McCauley, Mary M AU - Miller, Ted AD - National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts. Division of Infectious Diseases, Children's Hospital Boston, Boston, Massachusetts. Capitol Outcomes Research, Inc, Alexandria, Virginia. National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Department of Health and Human Services, Rockville, Maryland. Pacific Institute for Research and Evaluation, Calverton, Maryland Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - S63 EP - S78 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - Supplement_1 SN - 0031-4005, 0031-4005 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Databases KW - Pertussis KW - Adolescence KW - Reviews KW - Economics KW - Neisseria meningitidis KW - Vaccines KW - Children KW - Human papillomavirus KW - Models KW - F 06905:Vaccines KW - J 02350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20892463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Projected+Cost-effectiveness+of+New+Vaccines+for+Adolescents+in+the+United+States&rft.au=Ortega-Sanchez%2C+Ismael+R%3BLee%2C+Grace+M%3BJacobs%2C+RJake%3BProsser%2C+Lisa+A%3BMolinari%2C+Noelle-Angelique%3BZhang%2C+Xinzhi%3BBaine%2C+William+B%3BMcCauley%2C+Mary+M%3BMiller%2C+Ted&rft.aulast=Ortega-Sanchez&rft.aufirst=Ismael&rft.date=2008-01-01&rft.volume=121&rft.issue=Supplement_1&rft.spage=S63&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pertussis; Databases; Reviews; Adolescence; Economics; Vaccines; Children; Models; Neisseria meningitidis; Human papillomavirus ER - TY - JOUR T1 - Unsupervised estimation of myocardial displacement from tagged MR sequences using nonrigid registration AN - 20857535; 8368679 AB - We propose a fully automatic cardiac motion estimation technique that uses nonrigid registration between temporally adjacent images to compute the myocardial displacement field from tagged MR sequences using as inputs (sources) both horizontally and vertically tagged images. We present a new multisource nonrigid registration algorithm employing a semilocal deformation model that provides controlled smoothness. The method requires no segmentation. We apply a multiresolution optimization strategy for better speed and robustness. The accuracy of the algorithm is assessed on experimental data (animal model) and healthy volunteer data by calculating the root mean square (RMS) difference in position between the estimated tag trajectories and manual tracings outlined by an expert. For the 20000 tag lines analyzed (45 slices over 20-40 time frames), the RMS difference between the automatic tag trajectories and the manually segmented tag trajectories was 0.51 pixels (0.25 mm) for the animal data and 0.49 pixels (0.49 mm) for the human volunteer data. The RMS difference in the separation between adjacent tag lines (RMS_TS) was also assessed, resulting in an RMS_TS of 0.40 pixels (0.19 mm) in the experimental data and 0.52 pixels (0.56 mm) in the volunteer data. These results confirm the subpixel accuracy achieved using the proposed methodology. Magn Reson Med 2007. JF - Magnetic Resonance in Medicine AU - Ledesma-Carbayo, Maria J AU - Derbyshire, J Andrew AU - Sampath, Smita AU - Santos, Andres AU - Desco, Manuel AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, emcveigh@nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 181 EP - 189 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Segmentation KW - Animal models KW - Algorithms KW - Image processing KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Unsupervised+estimation+of+myocardial+displacement+from+tagged+MR+sequences+using+nonrigid+registration&rft.au=Ledesma-Carbayo%2C+Maria+J%3BDerbyshire%2C+J+Andrew%3BSampath%2C+Smita%3BSantos%2C+Andres%3BDesco%2C+Manuel%3BMcVeigh%2C+Elliot+R&rft.aulast=Ledesma-Carbayo&rft.aufirst=Maria&rft.date=2008-01-01&rft.volume=59&rft.issue=1&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21444 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Algorithms; N.M.R.; Animal models; Segmentation; Image processing; Heart DO - http://dx.doi.org/10.1002/mrm.21444 ER - TY - JOUR T1 - Mercaptobenzothiazole allergenicity--role of the thiol group AN - 20853672; 8349363 AB - The rubber accelerator, 2-mercaptobenzothiazole (MBT), is known to cause allergic contact dermatitis (ACD), but the mechanism is unknown. The role of the thiol group in MBT's allergenicity was investigated in the present study. Guinea pigs were sensitized to MBT using a modified guinea pig maximization test (GPMT) and reactivity was assessed toward 2-mer-captobenzothiazole disulfide (MBTS), 2-hydroxybenzothiazole (HBT; thiol-substituted), 2-(methylthio)benzothiazok (MTBT; thiol-blocked), and benzothiazole (BT; thiol-lacking). MBT and MBTS, but not BT, HBT, or MTBT, elicited ACD in MBT-sensitized animals, demonstrating that the tliiol group is critical to MBT's allergenicity. In addition, both MBT and MBTS were shown to inhibit both glutathione reductase and thioredoxin reductase, and thus contribute to the stability of MBT-protein mixed disulfides. It is concluded that the probable haptenation mechanism of MBT is through initial oxidation to MBTS with subsequent reduction to form mixed disulfides with proteins. JF - Cutaneous and Ocular Toxicology AU - Chipinda, I AU - Zhang, X-D AU - Simoyi, R H AU - Siegel, P D AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA, pds3@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 103 EP - 116 VL - 27 IS - 2 SN - 1556-9527, 1556-9527 KW - mercaptobenzothiazole KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - glutathione reductase KW - Contact dermatitis KW - Allergenicity KW - Thioredoxin-disulfide reductase KW - Rubber KW - Mixed disulfides KW - contact dermatitis KW - Thiols KW - Oxidation KW - Benzothiazole KW - Proteins KW - H 14000:Toxicology KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20853672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenotransplantation&rft.atitle=Characterization+and+expansion+of+baboon+CD4+super%28%2B%29CD25+super%28%2B%29+Treg+cells+for+potential+use+in+a+non-human+primate+xenotransplantation+model&rft.au=Porter%2C+Cynthia+M%3BHorvath-Arcidiacono%2C+Judith+A%3BSingh%2C+Avneesh+K%3BHorvath%2C+Keith+A%3BBloom%2C+Eda+T%3BMohiuddin%2C+Muhammad+M&rft.aulast=Porter&rft.aufirst=Cynthia&rft.date=2007-07-01&rft.volume=14&rft.issue=4&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Xenotransplantation&rft.issn=0908665X&rft_id=info:doi/10.1111%2Fj.1399-3089.2007.00416.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - glutathione reductase; Mixed disulfides; Contact dermatitis; Allergenicity; Oxidation; Thiols; Benzothiazole; Rubber; Thioredoxin-disulfide reductase; contact dermatitis; Proteins DO - http://dx.doi.org/10.1080/15569520701713008 ER - TY - JOUR T1 - Comparison of Escherichia coli O157:H7 Enrichment in Spiked Produce Samples AN - 20845919; 8027180 AB - Two strains of Escherichia coli O157:H7 were spiked into six varieties of produce at approximately 0.5 CFU g super(-1). Samples were enriched by using the U.S. Food and Drug Administration (FDA) Bacteriological Analytical Manual (BAM) method and by using an experimental method incorporating acid shock. Target colonies were detectable on selective agars after 30 of 48 analyses with BAM enrichment and 48 of 48 analyses with acid enrichment. Real-time PCR screening of 24-h enrichment broths revealed the presence of the diagnostic stx sub(1) or stx sub(2) genes after 27 of 48 analyses with BAM enrichment and 42 of 48 analyses with acid enrichment. The efficiency of the enrichment varied with strain and type of produce spiked but overall was better with the experimental enrichment method. Modifications of both the acid enrichment and BAM enrichment methods also were tested. The acid method with a modified incubation temperature consistently yielded high rates of recovery (>10 super(8) CFU ml super(-1)), with no instances in which target cells could not be detected. Modification of the BAM procedure did not reproducibly improve enrichment efficiency. JF - Journal of Food Protection AU - Grant, Michael A AD - U.S. Food and Drug Administration, Pacific Regional Laboratory Northwest, 22201 23rd Drive S.E., Bothell, Washington 98021, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 139 EP - 145 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 71 IS - 1 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Temperature effects KW - Agar KW - Colonies KW - Shock KW - Colony-forming cells KW - Escherichia coli KW - Polymerase chain reaction KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20845919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Comparison+of+Escherichia+coli+O157%3AH7+Enrichment+in+Spiked+Produce+Samples&rft.au=Grant%2C+Michael+A&rft.aulast=Grant&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=71&rft.issue=1&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282008%2971%253C139%3ARNCOCO%253E2.3.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Agar; Colonies; Shock; Colony-forming cells; Polymerase chain reaction; Escherichia coli DO - http://dx.doi.org/10.1043/0362-028X(2008)71%3C139:RNCOCO%3E2.3.CO;2 ER - TY - JOUR T1 - A quantitative assay for measuring clearance of adenovirus vectors by Kupffer cells AN - 20819907; 8243987 AB - Kupffer cells are a major barrier to systemic adenovirus (Ad) gene therapy because they rapidly and efficiently clear virions from the circulation. The lack of a straightforward quantitative technique for selectively measuring uptake of Ad by Kupffer cells has made it difficult to study the mechanisms by which they recognize Ad. A new method was developed that relies on immunofluorescent detection of Ad within Kupffer cells in mouse liver sections, followed by confocal microscopy and computerized image analysis. The method is sensitive, quantitative and reproducible, with a linear range spanning two orders of magnitude. As an example of the utility of this method, it was found that pre-injecting mice with polyinosinic acid reduces accumulation of Ad in Kupffer cells by approximately 90%. JF - Journal of Virological Methods AU - Smith, J S AU - Xu, Z AU - Byrnes, A P AD - Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA, JeffreyS.Smith@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 54 EP - 60 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 147 IS - 1 SN - 0166-0934, 0166-0934 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Expression vectors KW - Virions KW - Kupffer cells KW - Gene therapy KW - Hepatocytes KW - Confocal microscopy KW - Adenovirus KW - Image processing KW - W 30905:Medical Applications KW - V 22300:Methods KW - F 06900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20819907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=A+quantitative+assay+for+measuring+clearance+of+adenovirus+vectors+by+Kupffer+cells&rft.au=Smith%2C+J+S%3BXu%2C+Z%3BByrnes%2C+A+P&rft.aulast=Smith&rft.aufirst=J&rft.date=2008-01-01&rft.volume=147&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2007.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Virions; Expression vectors; Kupffer cells; Gene therapy; Hepatocytes; Confocal microscopy; Image processing; Adenovirus DO - http://dx.doi.org/10.1016/j.jviromet.2007.08.009 ER - TY - JOUR T1 - The Fda Critical Path Initiative and Its Influence on New Drug Development AN - 20815063; 8190336 AB - Societal expectations about drug safety and efficacy are rising while productivity in the pharmaceutical industry is falling. In 2004, the US Food and Drug Administration introduced the Critical Path Initiative with the intent of modernizing drug development by incorporating recent scientific advances, such as genomics and advanced imaging technologies, into the process. An important part of the initiative is the use of public-private partnerships and consortia to accomplish the needed research. This article explicates the reasoning behind the Critical Path Initiative and discusses examples of successful consortia. JF - Annual Review of Medicine AU - Woodcock, Janet AU - Woosley, Raymond AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20857, Janet.Woodcock@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1 EP - 12 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 59 SN - 0066-4219, 0066-4219 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Pharmaceuticals KW - Drug development KW - genomics KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20815063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Medicine&rft.atitle=The+Fda+Critical+Path+Initiative+and+Its+Influence+on+New+Drug+Development&rft.au=Woodcock%2C+Janet%3BWoosley%2C+Raymond&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2008-01-01&rft.volume=59&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Medicine&rft.issn=00664219&rft_id=info:doi/10.1146%2Fannurev.med.59.090506.155819 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Reviews; Pharmaceuticals; Drug development; genomics; imaging DO - http://dx.doi.org/10.1146/annurev.med.59.090506.155819 ER - TY - JOUR T1 - Mesenchymal stem cells in arthritic diseases AN - 20795692; 10885666 AB - Mesenchymal stem cells (MSCs), the nonhematopoietic progenitor cells found in various adult tissues, are characterized by their ease of isolation and their rapid growth In vitro while maintaining their differentiation potential, allowing for extensive culture expansion to obtain large quantities suitable for therapeutic use. These properties make MSCs an ideal candidate cell type as building blocks for tissue engineering efforts to regenerate replacement tissues and repair damaged structures as encountered in various arthritic conditions. Osteoarthritis (OA) is the most common arthritic condition and, like rheumatoid arthritis (RA), presents an inflammatory environment with immunological involvement and this has been an enduring obstacle that can potentially limit the use of cartilage tissue engineering. Recent advances in our understanding of the functions of MSCs have shown that MSCs also possess potent immunosuppression and anti-inflammation effects. In addition, through secretion of various soluble factors, MSCs can influence the local tissue environment and exert protective effects with an end result of effectively stimulating regeneration in situ. This function of MSCs can be exploited for their therapeutic application in degenerative joint diseases such as RA and OA. This review surveys the advances made in the past decade which have led to our current understanding of stem cell biology as relevant to diseases of the joint. The potential involvement of MSCs in the pathophysiology of degenerative joint diseases will also be discussed. Specifically, we will explore the potential of MSC-based cell therapy of OA and RA by means of functional replacement of damaged cartilage via tissue engineering as well as their anti-inflammatory and immunosuppressive activities. JF - Arthritis Research & Therapy AU - Chen, F H AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Building 50, 50 South Dr., Bethesda, MD 20892, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 223 VL - 10 IS - 5 SN - 1478-6354, 1478-6354 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Cartilage diseases KW - Osteoarthritis KW - Joint diseases KW - Therapeutic applications KW - Cell culture KW - Inflammation KW - Differentiation KW - Stem cells KW - Rheumatoid arthritis KW - Reviews KW - Mesenchyme KW - Immunosuppression KW - T 2030:Cartilage and Cartilage Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20795692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=Mesenchymal+stem+cells+in+arthritic+diseases&rft.au=Chen%2C+F+H%3BTuan%2C+R+S&rft.aulast=Chen&rft.aufirst=F&rft.date=2008-01-01&rft.volume=10&rft.issue=5&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2514 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Differentiation; Rheumatoid arthritis; Stem cells; Cartilage diseases; Osteoarthritis; Reviews; Joint diseases; Therapeutic applications; Cell culture; Mesenchyme; Immunosuppression; Inflammation DO - http://dx.doi.org/10.1186/ar2514 ER - TY - JOUR T1 - The Role of Standards and Guidance in Advancing Device Technology AN - 20791189; 8334218 AB - Advancing medical device technology from the design to delivery to patients takes many steps, typically including design or modification of an existing device, bench or laboratory testing, risk analysis, clinical testing (if appropriate), review of the device by regulatory agencies, and post-market surveillance by both the regulatory agency and the manufacturer. The development of technical guidance documents or international standards has made this process more efficient in the United States, though these processes are both underutilized and underappreciated. The history of the use of these approaches will be described, as well as recent progress and how the future of guidance and standards may evolve. JF - Journal of Biolaw & Business AU - Kessler, L AU - Herman, CL AD - Office of Science and Engineering Laboratories of the Center for Devices and Radiological Health (CDRH), Food and Drug Administration Y1 - 2008 PY - 2008 DA - 2008 SP - 10 EP - 14 VL - 11 IS - 1 SN - 1095-5127, 1095-5127 KW - Risk Abstracts KW - Historical account KW - Laboratory testing KW - medical equipment KW - USA KW - Reviews KW - International standardization KW - Technology KW - R2 23020:Technological risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20791189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biolaw+%26+Business&rft.atitle=The+Role+of+Standards+and+Guidance+in+Advancing+Device+Technology&rft.au=Kessler%2C+L%3BHerman%2C+CL&rft.aulast=Kessler&rft.aufirst=L&rft.date=2008-01-01&rft.volume=11&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biolaw+%26+Business&rft.issn=10955127&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Technology; Reviews; Laboratory testing; Historical account; medical equipment; International standardization ER - TY - JOUR T1 - The Rules Are Old, But the Game Is Changing: Life Sciences and the Foreign Corrupt Practices Act AN - 20785977; 8334220 AB - The Foreign Corrupt Practices Act turned 30 this year. Historically life sciences companies have not focused extensively on compliance with this decades-old statute, as enforcement actions were relatively few and tended to target companies in other industries. But as the biotechnology industry and the FCPA enter their fourth decade the game is changing. Regulators are ramping up overall enforcement and increasing their scrutiny of life sciences companies. This increased enforcement coincides with industry trends towards increased cross-border relationships and access to emerging markets. This article discusses this environment of heightened risk and provides insights for companies looking to mitigate risk and play by the changing rules of the game. JF - Journal of Biolaw & Business AU - Acosta, T AD - U.S. Department of Health and Human Services (OIG) in Washington, DC, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 19 EP - 21 VL - 11 IS - 1 SN - 1095-5127, 1095-5127 KW - Foreign Corrupt Practices Act KW - Risk Abstracts KW - Historical account KW - emerging markets KW - Compliance KW - Biotechnology KW - Legislation KW - R2 23090:Policy and planning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20785977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biolaw+%26+Business&rft.atitle=The+Rules+Are+Old%2C+But+the+Game+Is+Changing%3A+Life+Sciences+and+the+Foreign+Corrupt+Practices+Act&rft.au=Acosta%2C+T&rft.aulast=Acosta&rft.aufirst=T&rft.date=2008-01-01&rft.volume=11&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biolaw+%26+Business&rft.issn=10955127&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Compliance; Legislation; Historical account; emerging markets; Biotechnology ER - TY - JOUR T1 - Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study AN - 20735944; 8035947 AB - Meats cooked at high temperatures, such as pan-frying or grilling, are a source of carcinogenic heterocyclic amines and polycyclic aromatic hydrocarbons. We prospectively examined the association between meat types, meat cooking methods, meat doneness, and meat mutagens and the risk for prostate cancer in the Agricultural Health Study. We estimated relative risks and 95% confidence intervals (95% CI) for prostate cancer using Cox proportional hazards regression using age as the underlying time metric and adjusting for state of residence, race, smoking status, and family history of prostate cancer. During 197,017 person-years of follow-up, we observed 668 incident prostate cancer cases (613 of these were diagnosed after the first year of follow-up and 140 were advanced cases) among 23,080 men with complete dietary data. We found no association between meat type or specific cooking method and prostate cancer risk. However, intake of well or very well done total meat was associated with a 1.26-fold increased risk of incident prostate cancer (95% CI, 1.02-1.54) and a 1.97-fold increased risk of advanced disease (95% CI, 1.26-3.08) when the highest tertile was compared with the lowest. Risks for the two heterocyclic amines 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline and 2-amino-3,8-dimethylimidazo-[4,5-b]quinoxaline were of borderline significance for incident disease [1.24 (95% CI, 0.96-1.59) and 1.20 (95% CI, 0.93-1.55), respectively] when the highest quintile was compared with the lowest. In conclusion, well and very well done meat was associated with an increased risk for prostate cancer in this cohort. (Cancer Epidemiol Biomarkers Prev 2008; 17(1):80-7) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Koutros, Stella AU - Cross, Amanda J AU - Sandler, Dale P AU - Hoppin, Jane A AU - Ma, Xiaomei AU - Zheng, Tongzhang AU - Alavanja, Michael CR AU - Sinha, Rashmi AD - Occupational and Environmental Epidemiology Branch and Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 80 EP - 87 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 1 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Mutagens KW - Age KW - Smoking KW - Genetics KW - Carcinogenicity KW - prevention KW - cooking KW - prostate cancer KW - Diets KW - Bioindicators KW - Amines KW - Cancer KW - polycyclic aromatic hydrocarbons KW - high temperature KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20735944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Meat+and+Meat+Mutagens+and+Risk+of+Prostate+Cancer+in+the+Agricultural+Health+Study&rft.au=Koutros%2C+Stella%3BCross%2C+Amanda+J%3BSandler%2C+Dale+P%3BHoppin%2C+Jane+A%3BMa%2C+Xiaomei%3BZheng%2C+Tongzhang%3BAlavanja%2C+Michael+CR%3BSinha%2C+Rashmi&rft.aulast=Koutros&rft.aufirst=Stella&rft.date=2008-01-01&rft.volume=17&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - prostate cancer; Cancer; Bioindicators; cooking; Mutagens; Amines; Genetics; Carcinogenicity; Diets; polycyclic aromatic hydrocarbons; prevention; high temperature; Smoking; Age ER - TY - JOUR T1 - A regulatory perspective on the development of gene therapy for Parkinson's disease AN - 20734385; 8750614 JF - Experimental Neurology AU - Havert, Michael B AD - Food and Drug Administration, Center for Biologics Evaluation and Review, Office of Cellular, Tissue, and Gene Therapies, Division of Cellular and Gene Therapies, 1401 Rockville Pike, HFM-720, Rockville, MD 20852, USA, mike.havert@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 48 EP - 50 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 209 IS - 1 SN - 0014-4886, 0014-4886 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neurodegenerative diseases KW - Movement disorders KW - Gene therapy KW - Parkinson's disease KW - W 30905:Medical Applications KW - N3 11023:Neurogenetics KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20734385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Neurology&rft.atitle=A+regulatory+perspective+on+the+development+of+gene+therapy+for+Parkinson%27s+disease&rft.au=Havert%2C+Michael+B&rft.aulast=Havert&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=209&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Experimental+Neurology&rft.issn=00144886&rft_id=info:doi/10.1016%2Fj.expneurol.2007.08.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Movement disorders; Gene therapy; Parkinson's disease DO - http://dx.doi.org/10.1016/j.expneurol.2007.08.010 ER - TY - JOUR T1 - Structure and Function of the Virulence-Associated High-Temperature Requirement A of Mycobacterium tuberculosis AN - 20712785; 8236740 AB - The high-temperature requirement A (HtrA) family of serine proteases has been shown to play an important role in the environmental and cellular stress damage control system in Escherichia coli. Mycobacterium tuberculosis (Mtb) has three putative HtrA-like proteases, HtrA1, HtrA2, and HtrA3. The deletion of htrA2 gives attenuated virulence in a mouse model of TB. Biochemical analysis reveals that HtrA2 can function both as a protease and as a chaperone. The three-dimensional structure of HtrA2 determined at 2.0 Aa resolution shows that the protease domains form the central core of the trimer and the PDZ domains extend to the periphery. Unlike E. coli DegS and DegP, the protease is naturally active due to the formation of the serine protease-like catalytic triad and its uniquely designed oxyanion hole. Both protease and PDZ binding pockets of each HtrA2 molecule are occupied by autoproteolytic peptide products and reveal clues for a novel autoregulatory mechanism that might have significant importance in HtrA-associated virulence of Mtb. JF - Biochemistry (Washington) AU - Russell, David H AU - Jacobs, William R AU - MohamedMohaideen, Nilofar N AU - Williams, Brad J AU - Sacchettini, James C AU - Palaninathan, Satheesh K AU - Morin, Paul M AU - Braunstein, Miriam AU - Tichy, Shane E AU - Locker, Joseph AD - Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843, Department of Chemistry, Texas A&M University, College Station, Texas 77842, Howard Hughes Medical Institute, Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, U.S. Food and Drug Administration, Microbiological Sciences Branch, Jamaica, New York 11433, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 6092 EP - 6102 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 47 IS - 23 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Virulence KW - Serine proteinase KW - Structure-function relationships KW - Escherichia coli KW - Animal models KW - Biochemical analysis KW - Stress KW - Tuberculosis KW - Chaperones KW - Serine KW - Mycobacterium tuberculosis KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20712785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Structure+and+Function+of+the+Virulence-Associated+High-Temperature+Requirement+A+of+Mycobacterium+tuberculosis&rft.au=Russell%2C+David+H%3BJacobs%2C+William+R%3BMohamedMohaideen%2C+Nilofar+N%3BWilliams%2C+Brad+J%3BSacchettini%2C+James+C%3BPalaninathan%2C+Satheesh+K%3BMorin%2C+Paul+M%3BBraunstein%2C+Miriam%3BTichy%2C+Shane+E%3BLocker%2C+Joseph&rft.aulast=Russell&rft.aufirst=David&rft.date=2008-01-01&rft.volume=47&rft.issue=23&rft.spage=6092&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi701929m LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Virulence; Serine proteinase; Structure-function relationships; Animal models; Stress; Biochemical analysis; Chaperones; Tuberculosis; Serine; Escherichia coli; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1021/bi701929m ER - TY - JOUR T1 - Potential Use of DNA Barcodes in Regulatory Science: Applications of the Regulatory Fish Encyclopedia AN - 20686448; 8027193 AB - The use of a DNA-based identification system (DNA barcoding) founded on the mitochondrial gene cytochrome c oxidase subunit I (COI) was investigated for updating the U.S. Food and Drug Administration Regulatory Fish Encyclopedia (RFE; http://www.cfsan.fda.gov/ similar to frf/rfe0.html). The RFE is a compilation of data used to identify fish species. It was compiled to help regulators identify species substitution that could result in potential adverse health consequences or could be a source of economic fraud. For each of many aquatic species commonly sold in the United States, the RFE includes high-resolution photographs of whole fish and their marketed product forms and species-specific biochemical patterns for authenticated fish species. These patterns currently include data from isoelectric focusing studies. In this article, we describe the generation of DNA barcodes for 172 individual authenticated fish representing 72 species from 27 families contained in the RFE. These barcode sequences can be used as an additional identification resource. In a blind study, 60 unknown fish muscle samples were barcoded, and the results were compared with the RFE barcode reference library. All 60 samples were correctly identified to species based on the barcoding data. Our study indicates that DNA barcoding can be a powerful tool for species identification and has broad potential applications. JF - Journal of Food Protection AU - Yancy, Haile F AU - Zemlak, Tyler S AU - Mason, Jacquline A AU - Washington, Jewell D AU - Tenge, Bradley J AU - Nguyen, Ngoc-Lan T AU - Barnett, James D AU - Savary, Warren E AU - Hill, Walter E AU - Moore, Michelle M AU - Fry, Frederick S AU - Randolph, Spring C AU - Rogers, Patricia L AU - Hebert, Paul DN AD - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, Maryland 20708, USA Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 210 EP - 217 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com] VL - 71 IS - 1 SN - 0362-028X, 0362-028X KW - ASFA Marine Biotechnology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Biochemistry Abstracts 2: Nucleic Acids KW - Biological surveys KW - Institutional resources KW - Nucleotide sequence KW - Muscles KW - Mitochondria KW - Cytochrome-c oxidase KW - Isoelectric focusing KW - Fishery biology KW - Pisces KW - Population genetics KW - USA KW - Encyclopaedias KW - Economics KW - Photographs KW - DNA KW - Nature conservation KW - Q5 08523:Conservation, wildlife management and recreation KW - Q4 27740:Products KW - Q1 08109:Books, atlases and charts KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20686448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Potential+Use+of+DNA+Barcodes+in+Regulatory+Science%3A+Applications+of+the+Regulatory+Fish+Encyclopedia&rft.au=Yancy%2C+Haile+F%3BZemlak%2C+Tyler+S%3BMason%2C+Jacquline+A%3BWashington%2C+Jewell+D%3BTenge%2C+Bradley+J%3BNguyen%2C+Ngoc-Lan+T%3BBarnett%2C+James+D%3BSavary%2C+Warren+E%3BHill%2C+Walter+E%3BMoore%2C+Michelle+M%3BFry%2C+Frederick+S%3BRandolph%2C+Spring+C%3BRogers%2C+Patricia+L%3BHebert%2C+Paul+DN&rft.aulast=Yancy&rft.aufirst=Haile&rft.date=2008-01-01&rft.volume=71&rft.issue=1&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282008%2971%253C210%3ARNPUOD%253E2.3.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Biological surveys; Population genetics; Institutional resources; Encyclopaedias; Nucleotide sequence; Photographs; Nature conservation; DNA; Fishery biology; Economics; Muscles; Mitochondria; Cytochrome-c oxidase; Isoelectric focusing; Pisces; USA DO - http://dx.doi.org/10.1043/0362-028X(2008)71%3C210:RNPUOD%3E2.3.CO;2 ER - TY - JOUR T1 - Equivalency of a personal dust monitor to the current United States coal mine respirable dust sampler AN - 20630633; 8045234 AB - The United States National Institute for Occupational Safety and Health, through an informal partnership with industry, labor, and the United States Mine Safety and Health Administration, has developed and tested a new instrument known as the Personal Dust Monitor (PDM). The new dust monitor is an integral part of the cap lamp that coal miners normally carry to work and provides continuous information about the concentration of respirable coal mine dust within the breathing zone of that individual. Previous laboratory testing demonstrated that there is a 95% confidence that greater than 95% of individual PDM measurements fall within plus or minus 25% of reference measurements. The work presented in this paper focuses on the relationship between the PDM and respirable dust concentrations currently measured by a coal mine dust personal sampler unit utilizing a 10 mm Dorr-Oliver nylon cyclone. The United Kingdom Mining Research Establishment instrument, used as the basis for coal mine respirable dust standards, had been designed specifically to match the United Kingdom British Medical Research Council (BMRC) criterion. The personal sampler is used with a 1.38 multiplier to convert readings to the BMRC criterion. A stratified random sampling design incorporating a proportionate allocation strategy was used to select a sample of mechanized mining units representative of all US underground coal mines. A sample of 180 mechanized mining units was chosen, representing approximately 20% of the mechanized mining units in production at the time the sample was selected. A total of 129 valid PDM/personal sampler dust sample sets were obtained. A weighted linear regression analysis of this data base shows that, in comparison with the personal sampler, the PDM requires a mass equivalency conversion multiplier of 1.05 [95% C.I. = (1.03, 1.08)] when the small intercept term is removed from the analysis. Removal of the intercept term results in a personal sampler-equivalent concentration increase of 2.9% at a PDM measurement of 2.0 mg m super(3). JF - Journal of Environmental Monitoring AU - Page, S J AU - Volkwein, J C AU - Vinson, R P AU - Joy, G J AU - Mischler, SE AU - Tuchman, D P AU - McWilliams, L J AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 96 EP - 101 VL - 10 IS - 1 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Safety regulations KW - Laboratory testing KW - Coal KW - medical research KW - Dust KW - USA KW - councils KW - Air sampling KW - Mining KW - Occupational exposure KW - Data bases KW - Monitoring instruments KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20630633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Equivalency+of+a+personal+dust+monitor+to+the+current+United+States+coal+mine+respirable+dust+sampler&rft.au=Page%2C+S+J%3BVolkwein%2C+J+C%3BVinson%2C+R+P%3BJoy%2C+G+J%3BMischler%2C+SE%3BTuchman%2C+D+P%3BMcWilliams%2C+L+J&rft.aulast=Page&rft.aufirst=S&rft.date=2008-01-01&rft.volume=10&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb714381h LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Safety regulations; Laboratory testing; councils; Air sampling; medical research; Mining; Coal; Data bases; Occupational exposure; Dust; Monitoring instruments; USA DO - http://dx.doi.org/10.1039/b714381h ER - TY - JOUR T1 - Chronic Inhalation of Short Asbestos: Lung Fiber Burdens and Histopathology for Monkeys Maintained for 11.5 Years after Exposure AN - 20536496; 8017403 AB - In an earlier report, Platek et al. (1985) presented the results of an 18-month inhalation exposure of rats and monkeys to short chrysotile asbestos. The mean chamber exposure level was 1.0 mg/m3with an average of 0.79 fibers/ml > 5 is a subset of m in length. Gross and histopathological examination of exposed and control rats indicated no treatment-related lesions. Asbestos bodies adjacent to the terminal bronchioles, but no fibrosis, were found in lung biopsy tissue taken from the exposed monkeys at 10 months post-exposure. Fifteen monkeys (9 exposed and 6 controls) from this study were maintained for 11.5 years following exposure. Lung fiber burdens were determined by transmission electron microscopy. The mean lung burden (± standard deviation) for 59 samples from exposed monkeys was 63 ± 30X 106 fibers/g dry lung (range, 18-139 X 106). The geometric mean fiber length was 3.5 is a subset of m with 35% of the fibers being > 5 is a subset of m in length. These data indicate some chrysotile fibers are durable in vivo for a significant period of time. Lungs were examined grossly and microscopically. No lesions attributable to the inhalation exposure were noted. Asbestos bodies were seen in the lungs of treated monkeys, primarily in the interstitium near bronchioles or small pulmonary blood vessels (which also may have been near to bronchioles just out of the plane of section). JF - Inhalation Toxicology AU - Stettler, Lloyd E AU - Sharpnack, Douglas D AU - Krieg, Edward F AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 63 EP - 73 PB - Taylor & Francis, 325 Chestnut Street Suite 800 Philadelphia PA 19106 USA, [URL:http://www.taylorandfrancis.com/] VL - 20 IS - 1 SN - 0895-8378, 0895-8378 KW - Toxicology Abstracts KW - Inhalation KW - Fibers KW - Asbestos KW - Standard deviation KW - Blood vessels KW - Lung KW - Fibrosis KW - Transmission electron microscopy KW - Biopsy KW - Chrysotile KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20536496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Brune%2C+Jurgen%3BSapko%2C+Michael%3BZipf%2C+Karl&rft.aulast=Brune&rft.aufirst=Jurgen&rft.date=2007-07-01&rft.volume=&rft.issue=&rft.spage=84p&rft.isbn=&rft.btitle=Explosion+Pressure+Design+Criteria+for+New+Seals+in+U.S.+Coal+Mines&rft.title=Explosion+Pressure+Design+Criteria+for+New+Seals+in+U.S.+Coal+Mines&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inhalation; Fibers; Asbestos; Standard deviation; Blood vessels; Fibrosis; Lung; Transmission electron microscopy; Biopsy; Chrysotile DO - http://dx.doi.org/10.1080/08958370701665566 ER - TY - JOUR T1 - Air pollution and risk of urinary bladder cancer in a case-control study in Spain AN - 20508662; 7936958 AB - OBJECTIVES: Air pollution has been associated with an increased risk for lung cancer. We examined whether long-term air pollution is associated with bladder cancer risk. METHODS: Information from a case-control study in Spain that included 1219 incident cases and 1271 hospital controls was used. Information on residential history including several indicators of exposure to air pollution and other potential risk factors was collected in a face-to-face computerised personal interview. Odds ratios (OR) and 95% confidence intervals (95% CI) were adjusted for age, gender, region, smoking, occupation, water contaminants and diet. RESULTS: Living more than 40 years in a city with a population of more than 100 000 was associated with an increased risk for bladder cancer overall (OR 1.30, 95% CI 1.04 to 1.63). Emissions of polycyclic aromatic hydrocarbons and diesel from industries near the residence, as evaluated by experts, were associated with an increased risk (OR 1.29, 95% CI 0.85 to 1.98), while lower or no excess risks were observed for other pollution-related variables. Odds ratios among never smokers tended to be higher than among smokers. CONCLUSIONS: The small to moderate positive associations found for several indices of air pollution and bladder cancer, while suggestive of excess risk, require further evaluation in other settings. JF - Occupational and Environmental Medicine AU - Castano-Vinyals, Gemma AU - Cantor, Kenneth P AU - Malats, Nuria AU - Tardon, Adonina AU - Garcia-Closas, Reina AU - Serra, Consol AU - Carrato, Alfredo AU - Rothman, Nathaniel AU - Vermeulen, Roel AU - Silverman, Debra AU - Dosemeci, Mustafa AU - Kogevinas, Manolis AD - Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Barcelona, Spain. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. Universidad de Oviedo, Oviedo, Spain. Unidad de Investigacion, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain. Universitat Pompeu Fabra, Barcelona, Spain. Consorci Hospitalari Parc Tauli, Sabadell, Spain. Hospital General de Elche, Elche, Spain. Institute of Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands. Department of Social Medicine, Medical School, University of Crete, Herakleion, Crete, Greece. CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 56 EP - 60 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 1 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts; Pollution Abstracts KW - Historical account KW - Age KW - Spain KW - Pollution effects KW - urinary bladder KW - Smoking KW - Risk factors KW - Emissions KW - Urban areas KW - Lung cancer KW - Diets KW - Polycyclic aromatic hydrocarbons KW - Urinary bladder KW - Cancer KW - Air pollution KW - Gender KW - polycyclic aromatic hydrocarbons KW - Diesel KW - Contaminants KW - emergency medical services KW - Hospitals KW - X 24490:Other KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20508662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Air+pollution+and+risk+of+urinary+bladder+cancer+in+a+case-control+study+in+Spain&rft.au=Castano-Vinyals%2C+Gemma%3BCantor%2C+Kenneth+P%3BMalats%2C+Nuria%3BTardon%2C+Adonina%3BGarcia-Closas%2C+Reina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BRothman%2C+Nathaniel%3BVermeulen%2C+Roel%3BSilverman%2C+Debra%3BDosemeci%2C+Mustafa%3BKogevinas%2C+Manolis&rft.aulast=Castano-Vinyals&rft.aufirst=Gemma&rft.date=2008-01-01&rft.volume=65&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; Air pollution; Smoking; Polycyclic aromatic hydrocarbons; Urinary bladder; Risk factors; Diesel; Contaminants; Lung cancer; Hospitals; Historical account; Age; Pollution effects; Cancer; urinary bladder; Gender; Emissions; polycyclic aromatic hydrocarbons; emergency medical services; Urban areas; Spain ER - TY - JOUR T1 - Dialysis Surveillance Report: National Healthcare Safety Network (NHSN)-Data Summary for 2006 AN - 20473995; 9154874 AB - AbstractThirty-two outpatient hemodialysis providers in the United States voluntarily reported 3699 adverse events to the Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN) during 2006. These providers were previously enrolled in the Dialysis Surveillance Network. The pooled mean rates of hospitalization among patients with arteriovenous fistulas, grafts, permanent and temporary central venous catheters were 7.7, 9.2, 15.7, and 34.7 per 100 patient-months, respectively. For bloodstream infection the pooled mean rates were 0.5, 0.9, 4.2, and 27.1 per 100 patient-months in these groups. Among the 599 isolates reported, 461 (77%) represented access-associated blood stream infections in patients with central lines, and 138 (23%) were in patients with fistulas or grafts. The microorganisms most frequently identified were common skin contaminants (e.g., coagulase-negative staphylococci). In 2007, enrollment in NHSN opened to all providers of outpatient hemodialysis. Specific information is available at http://www.cdc.gov/ncidod/dhqp/nhsn_FAQenrollment.html. JF - Seminars in Dialysis AU - Klevens, RMonina AU - Edwards, Jonathan R AU - Andrus, Mary L AU - Peterson, Kelly D AU - Dudeck, Margaret A AU - Horan, Teresa C AD - Division of Healthcare Quality Promotion, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, rmk2@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 24 EP - 28 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 21 IS - 1 SN - 0894-0959, 0894-0959 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Blood KW - Skin KW - Microorganisms KW - Disease control KW - Catheters KW - Infection KW - Contaminants KW - Hemodialysis KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20473995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Dialysis&rft.atitle=Dialysis+Surveillance+Report%3A+National+Healthcare+Safety+Network+%28NHSN%29-Data+Summary+for+2006&rft.au=Klevens%2C+RMonina%3BEdwards%2C+Jonathan+R%3BAndrus%2C+Mary+L%3BPeterson%2C+Kelly+D%3BDudeck%2C+Margaret+A%3BHoran%2C+Teresa+C&rft.aulast=Klevens&rft.aufirst=RMonina&rft.date=2008-01-01&rft.volume=21&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Dialysis&rft.issn=08940959&rft_id=info:doi/10.1111%2Fj.1525-139X.2007.00379.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Blood; Skin; Catheters; Disease control; Microorganisms; Contaminants; Infection; Hemodialysis DO - http://dx.doi.org/10.1111/j.1525-139X.2007.00379.x ER - TY - JOUR T1 - The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies AN - 20352121; 9023569 AB - Background Reproducibility is a fundamental requirement in scientific experiments. Some recent publications have claimed that microarrays are unreliable because lists of differentially expressed genes (DEGs) are not reproducible in similar experiments. Meanwhile, new statistical methods for identifying DEGs continue to appear in the scientific literature. The resultant variety of existing and emerging methods exacerbates confusion and continuing debate in the microarray community on the appropriate choice of methods for identifying reliable DEG lists. Results Using the data sets generated by the MicroArray Quality Control (MAQC) project, we investigated the impact on the reproducibility of DEG lists of a few widely used gene selection procedures. We present comprehensive results from inter-site comparisons using the same microarray platform, cross-platform comparisons using multiple microarray platforms, and comparisons between microarray results and those from TaqMan - the widely regarded "standard" gene expression platform. Our results demonstrate that (1) previously reported discordance between DEG lists could simply result from ranking and selecting DEGs solely by statistical significance (P) derived from widely used simple t-tests; (2) when fold change (FC) is used as the ranking criterion with a non-stringent P-value cutoff filtering, the DEG lists become much more reproducible, especially when fewer genes are selected as differentially expressed, as is the case in most microarray studies; and (3) the instability of short DEG lists solely based on P-value ranking is an expected mathematical consequence of the high variability of the t-values; the more stringent the P-value threshold, the less reproducible the DEG list is. These observations are also consistent with results from extensive simulation calculations. Conclusion We recommend the use of FC-ranking plus a non-stringent P cutoff as a straightforward and baseline practice in order to generate more reproducible DEG lists. Specifically, the P-value cutoff should not be stringent (too small) and FC should be as large as possible. Our results provide practical guidance to choose the appropriate FC and P-value cutoffs when selecting a given number of DEGs. The FC criterion enhances reproducibility, whereas the P criterion balances sensitivity and specificity. JF - BMC Bioinformatics AU - Shi, Leming AU - Jones, Wendell D AU - Jensen, Roderick V AU - Harris, Stephen C AU - Perkins, Roger G AU - Goodsaid, Federico M AU - Guo, Lei AU - Croner, Lisa J AU - Boysen, Cecilie AU - Fang, Hong AU - Qian, Feng AU - Amur, Shashi AU - Bao, Wenjun AU - Barbacioru, Catalin C AU - Bertholet, Vincent AU - Cao, Xiaoxi Megan AU - Chu, Tzu-Ming AU - Collins, Patrick J AU - Fan, Xiao-hui AU - Frueh, Felix W AU - Fuscoe, James C AU - Guo, Xu AU - Han, Jing AU - Herman, Damir AU - Hong, Huixiao AU - Kawasaki, Ernest S AU - Li, Quan-Zhen AU - Luo, Yuling AU - Ma, Yunqing AU - Mei, Nan AU - Peterson, Ron L AU - Puri, Raj K AU - Shippy, Richard AU - Su, Zhenqiang AU - Sun, Yongming Andrew AU - Sun, Hongmei AU - Thorn, Brett AU - Turpaz, Yaron AU - Wang, Charles AU - Wang, Sue Jane AU - Warrington, Janet A AU - Willey, James C AU - Wu, Jie AU - Xie, Qian AU - Zhang, Liang AU - Zhang, Lu AU - Zhong, Sheng AU - Wolfinger, Russell D AU - Tong, Weida AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, leming.shi@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - S10 PB - BioMed Central Ltd., Middlesex House VL - 9 IS - Suppl 9 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Statistics KW - Data processing KW - Quality control KW - Discordance KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20352121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=The+balance+of+reproducibility%2C+sensitivity%2C+and+specificity+of+lists+of+differentially+expressed+genes+in+microarray+studies&rft.au=Shi%2C+Leming%3BJones%2C+Wendell+D%3BJensen%2C+Roderick+V%3BHarris%2C+Stephen+C%3BPerkins%2C+Roger+G%3BGoodsaid%2C+Federico+M%3BGuo%2C+Lei%3BCroner%2C+Lisa+J%3BBoysen%2C+Cecilie%3BFang%2C+Hong%3BQian%2C+Feng%3BAmur%2C+Shashi%3BBao%2C+Wenjun%3BBarbacioru%2C+Catalin+C%3BBertholet%2C+Vincent%3BCao%2C+Xiaoxi+Megan%3BChu%2C+Tzu-Ming%3BCollins%2C+Patrick+J%3BFan%2C+Xiao-hui%3BFrueh%2C+Felix+W%3BFuscoe%2C+James+C%3BGuo%2C+Xu%3BHan%2C+Jing%3BHerman%2C+Damir%3BHong%2C+Huixiao%3BKawasaki%2C+Ernest+S%3BLi%2C+Quan-Zhen%3BLuo%2C+Yuling%3BMa%2C+Yunqing%3BMei%2C+Nan%3BPeterson%2C+Ron+L%3BPuri%2C+Raj+K%3BShippy%2C+Richard%3BSu%2C+Zhenqiang%3BSun%2C+Yongming+Andrew%3BSun%2C+Hongmei%3BThorn%2C+Brett%3BTurpaz%2C+Yaron%3BWang%2C+Charles%3BWang%2C+Sue+Jane%3BWarrington%2C+Janet+A%3BWilley%2C+James+C%3BWu%2C+Jie%3BXie%2C+Qian%3BZhang%2C+Liang%3BZhang%2C+Lu%3BZhong%2C+Sheng%3BWolfinger%2C+Russell+D%3BTong%2C+Weida&rft.aulast=Shi&rft.aufirst=Leming&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+9&rft.spage=S10&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S9-S10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Statistics; Quality control; Discordance; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-9-S9-S10 ER - TY - JOUR T1 - Application of bioinformatics-coupled experimental analysis reveals a new transport-competent nuclear localization signal in the nucleoprotein of Influenza A virus strain AN - 20349193; 9023642 AB - Background Two nuclear localization sequences (NLS) in influenza A virus nucleoprotein (NP) have been demonstrated to be critical for nuclear import of NP and viral ribonucleoprotein complexes. However, a deletion mutant lacking these two signals was still able to localize to the nucleus suggesting the presence of yet another (a third) potential NLS in the NP protein. In order to identify the nature of this potential NLS signal in the NP of a WS/33L influenza virus A strain, we utilized the tools of bioinformatics coupled with functional experimental analyses in the present study. Results Comparison of the deduced aa sequence of NP of WS/33L strain with the published WS/33 NP sequences revealed that a single amino acid (aa) change (Met to Arg) at position 105 results in converting the flanking regions (between aa position 90-121, a 32-residue stretch) into two classical overlapping bipartite NLS (obpNLS). GenBank search revealed that 9 out of 500 published NP sequences contain a similar Arg at position 105 (instead of Met) with a 100% homology to the obpNLS region. Various NP-green fluorescent protein (GFP) fusion constructs with and without the signal (obpNLS-Arg super(105)) were utilized to understand the functional nature of this signal. We analyzed the transport competency of the expressed chimeric proteins in terms of their cellular localization by confocal immunofluorescence assay. Our analysis revealed that all NP-GFP constructs containing the wild-type (R super(105)) sequence localized predominantly to the nucleus. Constructs lacking the obpNLS or constructs with reverse mutation (R super(105 )to M super(105)) on the other hand exhibited predominant cytoplasmic localization pattern. Interestingly, when the 32 aa obpNLS was fused with an unrelated viral protein (rotavirus NSP6) that has been known to be cytoplasmic protein, the chimeric protein (obpNLS-NSP6) was efficiently transported into the nucleus, indicating an efficient nuclear transport function of the 32-residue obpNLS in the NP of WS/33L strain of influenza A virus. Conclusion This report while not only establishing a new NLS in the influenza A virus strain, it also reinforces the idea that proper application of bioinformatics-coupled experimental analysis serves as a powerful tool in identifying new functional signals in proteins of interest. JF - BMC Cell Biology AU - Ketha, Krishna Mohan V AU - Atreya, Chintamani D AD - Section of Cell Biology, Laboratory of Cellular Hematology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research (F.D.A.) Bethesda, MD 20892, USA, krishna.ketha@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 22 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Rotavirus KW - Deletion mutant KW - double prime NP protein KW - Nucleoproteins KW - Immunofluorescence KW - Methionine KW - Nuclear transport KW - Homology KW - Influenza A virus KW - Ribonucleoproteins KW - Bioinformatics KW - Fusion protein KW - Mutation KW - Amino acid sequence KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20349193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Cell+Biology&rft.atitle=Application+of+bioinformatics-coupled+experimental+analysis+reveals+a+new+transport-competent+nuclear+localization+signal+in+the+nucleoprotein+of+Influenza+A+virus+strain&rft.au=Ketha%2C+Krishna+Mohan+V%3BAtreya%2C+Chintamani+D&rft.aulast=Ketha&rft.aufirst=Krishna+Mohan&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=BMC+Cell+Biology&rft.issn=1471-2121&rft_id=info:doi/10.1186%2F1471-2121-9-22 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nuclear transport; Deletion mutant; Homology; double prime NP protein; Nucleoproteins; Ribonucleoproteins; Fusion protein; Immunofluorescence; Bioinformatics; Mutation; Methionine; Amino acid sequence; Rotavirus; Influenza A virus DO - http://dx.doi.org/10.1186/1471-2121-9-22 ER - TY - JOUR T1 - Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270 HapMap samples AN - 20346885; 9023576 AB - Background Genome-wide association studies (GWAS) aim to identify genetic variants (usually single nucleotide polymorphisms [SNPs]) across the entire human genome that are associated with phenotypic traits such as disease status and drug response. Highly accurate and reproducible genotype calling are paramount since errors introduced by calling algorithms can lead to inflation of false associations between genotype and phenotype. Most genotype calling algorithms currently used for GWAS are based on multiple arrays. Because hundreds of gigabytes (GB) of raw data are generated from a GWAS, the samples are typically partitioned into batches containing subsets of the entire dataset for genotype calling. High call rates and accuracies have been achieved. However, the effects of batch size (i.e., number of chips analyzed together) and of batch composition (i.e., the choice of chips in a batch) on call rate and accuracy as well as the propagation of the effects into significantly associated SNPs identified have not been investigated. In this paper, we analyzed both the batch size and batch composition for effects on the genotype calling algorithm BRLMM using raw data of 270 HapMap samples analyzed with the Affymetrix Human Mapping 500 K array set. Results Using data from 270 HapMap samples interrogated with the Affymetrix Human Mapping 500 K array set, three different batch sizes and three different batch compositions were used for genotyping using the BRLMM algorithm. Comparative analysis of the calling results and the corresponding lists of significant SNPs identified through association analysis revealed that both batch size and composition affected genotype calling results and significantly associated SNPs. Batch size and batch composition effects were more severe on samples and SNPs with lower call rates than ones with higher call rates, and on heterozygous genotype calls compared to homozygous genotype calls. Conclusion Batch size and composition affect the genotype calling results in GWAS using BRLMM. The larger the differences in batch sizes, the larger the effect. The more homogenous the samples in the batches, the more consistent the genotype calls. The inconsistency propagates to the lists of significantly associated SNPs identified in downstream association analysis. Thus, uniform and large batch sizes should be used to make genotype calls for GWAS. In addition, samples of high homogeneity should be placed into the same batch. JF - BMC Bioinformatics AU - Hong, Huixiao AU - Su, Zhenqiang AU - Ge, Weigong AU - Shi, Leming AU - Perkins, Roger AU - Fang, Hong AU - Xu, Joshua AU - Chen, James J AU - Han, Tao AU - Kaput, Jim AU - Fuscoe, James C AU - Tong, Weida AD - Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, Huixiao.Hong@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - S17 PB - BioMed Central Ltd., Middlesex House VL - 9 IS - Suppl 9 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Association analysis KW - Data processing KW - Vocalization behavior KW - Single-nucleotide polymorphism KW - Genotyping KW - Algorithms KW - Genotypes KW - Bioinformatics KW - Drugs KW - Gene mapping KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Assessing+batch+effects+of+genotype+calling+algorithm+BRLMM+for+the+Affymetrix+GeneChip+Human+Mapping+500+K+array+set+using+270+HapMap+samples&rft.au=Hong%2C+Huixiao%3BSu%2C+Zhenqiang%3BGe%2C+Weigong%3BShi%2C+Leming%3BPerkins%2C+Roger%3BFang%2C+Hong%3BXu%2C+Joshua%3BChen%2C+James+J%3BHan%2C+Tao%3BKaput%2C+Jim%3BFuscoe%2C+James+C%3BTong%2C+Weida&rft.aulast=Hong&rft.aufirst=Huixiao&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+9&rft.spage=S17&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S9-S17 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Association analysis; Data processing; Vocalization behavior; Single-nucleotide polymorphism; Genotyping; Algorithms; Bioinformatics; Genotypes; Drugs; Gene mapping DO - http://dx.doi.org/10.1186/1471-2105-9-S9-S17 ER - TY - JOUR T1 - Very Important Pool (VIP) genes - an application for microarray-based molecular signatures AN - 20346609; 9023587 AB - Background Advances in DNA microarray technology portend that molecular signatures from which microarray will eventually be used in clinical environments and personalized medicine. Derivation of biomarkers is a large step beyond hypothesis generation and imposes considerably more stringency for accuracy in identifying informative gene subsets to differentiate phenotypes. The inherent nature of microarray data, with fewer samples and replicates compared to the large number of genes, requires identifying informative genes prior to classifier construction. However, improving the ability to identify differentiating genes remains a challenge in bioinformatics. Results A new hybrid gene selection approach was investigated and tested with nine publicly available microarray datasets. The new method identifies a Very Important Pool (VIP) of genes from the broad patterns of gene expression data. The method uses a bagging sampling principle, where the re-sampled arrays are used to identify the most informative genes. Frequency of selection is used in a repetitive process to identify the VIP genes. The putative informative genes are selected using two methods, t-statistic and discriminatory analysis. In the t-statistic, the informative genes are identified based on p-values. In the discriminatory analysis, disjoint Principal Component Analyses (PCAs) are conducted for each class of samples, and genes with high discrimination power (DP) are identified. The VIP gene selection approach was compared with the p-value ranking approach. The genes identified by the VIP method but not by the p-value ranking approach are also related to the disease investigated. More importantly, these genes are part of the pathways derived from the common genes shared by both the VIP and p-ranking methods. Moreover, the binary classifiers built from these genes are statistically equivalent to those built from the top 50 p-value ranked genes in distinguishing different types of samples. Conclusion The VIP gene selection approach could identify additional subsets of informative genes that would not always be selected by the p-value ranking method. These genes are likely to be additional true positives since they are a part of pathways identified by the p-value ranking method and expected to be related to the relevant biology. Therefore, these additional genes derived from the VIP method potentially provide valuable biological insights. JF - BMC Bioinformatics AU - Su, Zhenqiang AU - Hong, Huixiao AU - Fang, Hong AU - Shi, Leming AU - Perkins, Roger AU - Tong, Weida AD - Center for Toxicoinformatics, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), 3900 NCTR Road, Jefferson, AR 72079, USA, zhenqiang.su@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - S9 PB - BioMed Central Ltd., Middlesex House VL - 9 IS - Suppl 9 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Principal components analysis KW - Hybrids KW - Bioinformatics KW - Sampling KW - Vasoactive intestinal peptide KW - DNA microarrays KW - biomarkers KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Very+Important+Pool+%28VIP%29+genes+-+an+application+for+microarray-based+molecular+signatures&rft.au=Su%2C+Zhenqiang%3BHong%2C+Huixiao%3BFang%2C+Hong%3BShi%2C+Leming%3BPerkins%2C+Roger%3BTong%2C+Weida&rft.aulast=Su&rft.aufirst=Zhenqiang&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+9&rft.spage=S9&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S9-S9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Hybrids; Principal components analysis; Sampling; Bioinformatics; biomarkers; DNA microarrays; Vasoactive intestinal peptide DO - http://dx.doi.org/10.1186/1471-2105-9-S9-S9 ER - TY - JOUR T1 - Prospective study of physical activity and risk of postmenopausal breast cancer AN - 20270744; 8921933 AB - Introduction To prospectively examine the relation of total, vigorous and non-vigorous physical activity to postmenopausal breast cancer risk. Methods We studied 32,269 women enrolled in the Breast Cancer Detection Demonstration Project Follow-up Study. Usual physical activity (including household, occupational and leisure activities) throughout the previous year was assessed at baseline using a self-administered questionnaire. Postmenopausal breast cancer cases were identified through self-reports, death certificates and linkage to state cancer registries. A Cox proportional hazards regression was used to estimate the relative risk and 95% confidence intervals of postmenopausal breast cancer associated with physical activity. Results During 269,792 person-years of follow-up from 1987 to 1998, 1506 new incident cases of postmenopausal breast cancer were ascertained. After adjusting for potential risk factors of breast cancer, a weak inverse association between total physical activity and postmenopausal breast cancer was suggested (relative risk comparing extreme quintiles = 0.87; 95% confidence interval = 0.74 to 1.02; p for trend = 0.21). That relation was almost entirely contributed by vigorous activity (relative risk comparing extreme categories = 0.87; 95% confidence interval = 0.74 to 1.02; p for trend = 0.08). The inverse association with vigorous activity was limited to women who were lean (ie, body mass index &25.0 kg/m super(2): relative risk = 0.68; 95% confidence interval = 0.54 to 0.85). In contrast, no association with vigorous activity was noted among women who were overweight or obese (ie, body mass index greater than or equal to 25.0 kg/m super(2): relative risk = 1.18; 95% confidence interval = 0.93 to 1.49; p for interaction = 0.008). Non-vigorous activity showed no relation to breast cancer (relative risk comparing extreme quintiles = 1.02; 95% confidence interval = 0.87 to 1.19; p for trend = 0.86). The physical activity and breast cancer relation was not specific to a certain hormone receptor subtype. Conclusions In this cohort of postmenopausal women, breast cancer risk reduction appeared to be limited to vigorous forms of activity; it was apparent among normal weight women but not overweight women, and the relation did not vary by hormone receptor status. Our findings suggest that physical activity acts through underlying biological mechanisms that are independent of body weight control. JF - Breast Cancer Research AU - Leitzmann, Michael F AU - Moore, Steven C AU - Peters, Tricia M AU - Lacey, James V AU - Schatzkin, Arthur AU - Schairer, Catherine AU - Brinton, Louise A AU - Albanes, Demetrius AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 6120 Executive Blvd., MSC 7232, Bethesda, MD 20892, USA, michael.leitzmann@klinik.uni-regensburg.de Y1 - 2008 PY - 2008 DA - 2008 SP - R92 PB - BioMed Central Ltd., Middlesex House VL - 10 IS - 5 SN - 1465-5411, 1465-5411 KW - Physical Education Index KW - Obesity KW - Body mass KW - Women KW - Breasts KW - Exercise KW - Activities KW - Trends KW - Hormones KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20270744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+Cancer+Research&rft.atitle=Prospective+study+of+physical+activity+and+risk+of+postmenopausal+breast+cancer&rft.au=Leitzmann%2C+Michael+F%3BMoore%2C+Steven+C%3BPeters%2C+Tricia+M%3BLacey%2C+James+V%3BSchatzkin%2C+Arthur%3BSchairer%2C+Catherine%3BBrinton%2C+Louise+A%3BAlbanes%2C+Demetrius&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=10&rft.issue=5&rft.spage=R92&rft.isbn=&rft.btitle=&rft.title=Breast+Cancer+Research&rft.issn=14655411&rft_id=info:doi/10.1186%2Fbcr2190 LA - English DB - Physical Education Index N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Body mass; Women; Breasts; Exercise; Trends; Activities; Hormones; Cancer DO - http://dx.doi.org/10.1186/bcr2190 ER - TY - JOUR T1 - Physicochemical Characteristics of Aerosol Particles Generated During the Milling of Beryllium Silicate Ores: Implications for Risk Assessment AN - 20239663; 8762249 AB - Inhalation of beryllium dusts generated during milling of ores and cutting of beryl-containing gemstones is associated with development of beryllium sensitization and low prevalence of chronic beryllium disease (CBD). Inhalation of beryllium aerosols generated during primary beryllium production and machining of the metal, alloys, and ceramics are associated with sensitization and high rates of CBD, despite similar airborne beryllium mass concentrations among these industries. Understanding the physicochemical properties of exposure aerosols may help to understand the differential immunopathologic mechanisms of sensitization and CBD and lead to more biologically relevant exposure standards. Properties of aerosols generated during the industrial milling of bertrandite and beryl ores were evaluated. Airborne beryllium mass concentrations among work areas ranged from 0.001 kg/m super(3) (beryl ore grinding) to 2.1 kg/m super(3) (beryl ore crushing). Respirable mass fractions of airborne beryllium-containing particles were 80% in high-energy input areas (beryl melting, beryl grinding). Particle specific surface area decreased with processing from feedstock ores to drumming final product beryllium hydroxide. Among work areas, beryllium was identified in three crystalline forms: beryl, poorly crystalline beryllium oxide, and beryllium hydroxide. In comparison to aerosols generated by high-CBD risk primary production processes, aerosol particles encountered during milling had similar mass concentrations, generally lower number concentrations and surface area, and contained no identifiable highly crystalline beryllium oxide. One possible explanation for the apparent low prevalence of CBD among workers exposed to beryllium mineral dusts may be that characteristics of the exposure material do not contribute to the development of lung burdens sufficient for progression from sensitization to CBD. In comparison to high-CBD risk exposures where the chemical nature of aerosol particles may confer higher bioavailability, respirable ore dusts likely confer considerably less. While finished product beryllium hydroxide particles may confer bioavailability similar to that of high-CBD risk aerosols, physical exposure factors (i.e., large particle sizes) may limit development of alveolar lung burdens. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Stefaniak, AB AU - Chipera, S J AU - Day, G A AU - Sabey, P AU - Dickerson, R M AU - Sbarra, D C AU - Duling, M G AU - Lawrence, R B AU - Stanton, M L AU - Scripsick, R C AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, AStefaniak@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1468 EP - 1481 VL - 71 IS - 21 SN - 1528-7394, 1528-7394 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; Risk Abstracts; Environment Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Risk assessment KW - Aerosol particles KW - Heavy metals KW - Particulates KW - Primary production KW - Dust KW - Melting KW - Bioavailability KW - Ores KW - Risk factors KW - Alloys KW - oxides KW - alloys KW - Occupational exposure KW - Berylliosis KW - Metals KW - Aerosols KW - Surface area KW - Physicochemical properties KW - Silicic acid KW - Alveoli KW - hydroxides KW - Ceramics KW - Lung KW - Beryllium KW - Drumming KW - Minerals KW - surface area KW - R2 23080:Industrial and labor KW - M2 551.510.42:Air Pollution (551.510.42) KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20239663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Physicochemical+Characteristics+of+Aerosol+Particles+Generated+During+the+Milling+of+Beryllium+Silicate+Ores%3A+Implications+for+Risk+Assessment&rft.au=Stefaniak%2C+AB%3BChipera%2C+S+J%3BDay%2C+G+A%3BSabey%2C+P%3BDickerson%2C+R+M%3BSbarra%2C+D+C%3BDuling%2C+M+G%3BLawrence%2C+R+B%3BStanton%2C+M+L%3BScripsick%2C+R+C&rft.aulast=Stefaniak&rft.aufirst=AB&rft.date=2008-01-01&rft.volume=71&rft.issue=21&rft.spage=1468&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390802349883 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Berylliosis; Inhalation; Aerosols; Heavy metals; Surface area; Silicic acid; Physicochemical properties; Primary production; Dust; Alveoli; Ceramics; Melting; Bioavailability; Ores; Lung; Risk factors; Beryllium; Drumming; oxides; alloys; Minerals; Occupational exposure; Aerosol particles; Metals; Particulates; hydroxides; Alloys; surface area DO - http://dx.doi.org/10.1080/15287390802349883 ER - TY - JOUR T1 - Hydrophilic Fungi and Ergosterol Associated with Respiratory Illness in a Water-Damaged Building AN - 20197925; 8044956 AB - Background: Damp building-related respiratory illnesses are an important public health issue. Objective: We compared three respiratory case groups defined by questionnaire responses [200 respiratory cases, 123 of the respiratory cases who met the epidemiologic asthma definition, and 49 of the epidemiologic asthma cases who had current physician-diagnosed asthma with post-occupancy onset] to a comparison group of 152 asymptomatic employees in an office building with a history of water damage. Methods: We analyzed dust samples collected from floors and chairs of 323 cases and comparisons for culturable fungi, ergosterol, endotoxin, and cat and dog allergens. We examined associations of total fungi, hydrophilic fungi (requiring water activity greater than or equal to 0.9), and ergosterol with the health outcomes using logistic regression models. Results: In models adjusted for demographics, respiratory illnesses showed significant linear exposure-response relationships to total culturable fungi [interquartile range odds ratios (IQR-OR) = 1.37-1.72], hydrophilic fungi (IQR-OR = 1.45-2.19), and ergosterol (IQR-OR = 1.54-1.60) in floor and chair dusts. Of three outcomes analyzed, current asthma with postoccupancy physician diagnosis was most strongly associated with exposure to hydrophilic fungi in models adjusted for ergosterol, endotoxin, and demographics (IQR-OR = 2.09 for floor and 1.79 for chair dusts). Ergosterol levels in floor dust were significantly associated with epidemiologic asthma independent of culturable fungi (IQR-OR = 1.54-1.55). Conclusions: Our findings extend the 2004 conclusions of the Institute of Medicine [Human health effects associated with damp indoor environments. In: Damp Indoor Spaces and Health. Washington DC:National Academies Press, 183-269] by showing that mold levels in dust were associated with new-onset asthma in this damp indoor environment Hydrophilic fungi and ergosterol as measures of fungal biomass may have promise as markers of risk of building-related respiratory diseases in damp indoor environments. JF - Environmental Health Perspectives AU - Park, J-H AU - Cox-Ganser, J M AU - Kreiss, K AU - White, S K AU - Rao, CY AD - National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, MS 2800, 1095 Willowdale Rd., Morgantown, WV 26505 USA, gzp8@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 45 EP - 50 VL - 116 IS - 1 SN - 0091-6765, 0091-6765 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - demography KW - Endotoxins KW - Historical account KW - Water activity KW - Molds KW - Respiratory diseases KW - Dust KW - Public health KW - Models KW - Demography KW - USA, Washington KW - Dose-response effects KW - Allergens KW - Water-borne diseases KW - Regression analysis KW - Inventories KW - Fungi KW - Asthma KW - Biomass KW - Indoor environments KW - Ergosterol KW - K 03410:Animal Diseases KW - X 24370:Natural Toxins KW - A 01490:Miscellaneous KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20197925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Hydrophilic+Fungi+and+Ergosterol+Associated+with+Respiratory+Illness+in+a+Water-Damaged+Building&rft.au=Park%2C+J-H%3BCox-Ganser%2C+J+M%3BKreiss%2C+K%3BWhite%2C+S+K%3BRao%2C+CY&rft.aulast=Park&rft.aufirst=J-H&rft.date=2008-01-01&rft.volume=116&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10355 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Endotoxins; Inventories; Fungi; Water activity; Asthma; Molds; Biomass; Dust; Models; Public health; Demography; Allergens; Dose-response effects; Regression analysis; Ergosterol; demography; Historical account; Water-borne diseases; Respiratory diseases; Indoor environments; USA, Washington DO - http://dx.doi.org/10.1289/ehp.10355 ER - TY - JOUR T1 - Process analytical technology: Non-destructive assessment of anastrozole entrapment within PLGA microparticles by near infrared spectroscopy and chemical imaging AN - 20064105; 10062988 AB - The objective of this study was to evaluate near-infrared (NIR) spectroscopy and imaging as approaches to assess anastrozole entrapment within PLGA microparticles. By varying the polymer concentration, three batches containing the same amount of the drug were prepared. The spectral features that allow NIR drug quantitation were evaluated and compared with a best fit line algorithm. Actual entrapment efficiencies (EEF) determined via a destructive method were used for construction of calibration models using partial least square regression (PLS) or the algorithm. On the other hand, a chemical imaging system based on array detector technology was used to rapidly collect high contrast NIR images of the formulated microparticles. A quantitative measure of anastrozole entrapped was determined by calculating the percentage standard deviation of the distribution of pixel intensities in the PLS score images and histograms. Concerning conventional NIR analysis, both methods were equivalent for the prediction of EEF over the range of polymer levels studied. Correlation coefficients of more than 0.992 were obtained for either the calibration or prediction of EEF by the two methods; 0.392% and 0.374% were the standard errors of calibration and prediction (SEC and SEP) obtained for the prediction of EEF using the fit line, respectively, whereas the prediction of the EEF by the partial least square regression showed a SEC of 0.195% and SEP of 0.179%. As a result, the spectral best fit algorithm method compared favourably to the multivariate PLS method, but was easier to develop. In contrast, NIR spectral imaging was capable of clearly differentiating the three batches, both qualitatively and quantitatively. The percentage standard deviation increased progressively by increasing the ratio of drug-to-polymer concentrations. In conclusion, both NIR approaches were capable of accurate assessment of drug entrapment within microparticles. In addition, the NIR spectral imaging system provides a rapid approach for acquiring spatial and spectral information on microparticles. JF - Journal of Microencapsulation AU - Zidan, A S AU - Sammour, O A AU - Hammad, M A AU - Megrab, N A AU - Habib, M J AU - Khan, M A AD - Division of Product Quality Research, Food and Drug Administration, Maryland, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 145 EP - 153 PB - Taylor & Francis, 1 Gunpowder Sq. London EC4A UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 25 IS - 3 SN - 0265-2048, 0265-2048 KW - Biotechnology and Bioengineering Abstracts KW - Anastrozole KW - I.R. radiation KW - microparticles KW - polylactide-co-glycolide KW - microencapsulation KW - Algorithms KW - spatial discrimination KW - Drug development KW - Drug screening KW - imaging KW - Standard deviation KW - I.R. spectroscopy KW - Regression analysis KW - Drugs KW - Quantitation KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20064105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microencapsulation&rft.atitle=Process+analytical+technology%3A+Non-destructive+assessment+of+anastrozole+entrapment+within+PLGA+microparticles+by+near+infrared+spectroscopy+and+chemical+imaging&rft.au=Zidan%2C+A+S%3BSammour%2C+O+A%3BHammad%2C+M+A%3BMegrab%2C+N+A%3BHabib%2C+M+J%3BKhan%2C+M+A&rft.aulast=Zidan&rft.aufirst=A&rft.date=2008-01-01&rft.volume=25&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microencapsulation&rft.issn=02652048&rft_id=info:doi/10.1080%2F02652040601034963 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - imaging; microparticles; Anastrozole; Algorithms; Standard deviation; polylactide-co-glycolide; I.R. spectroscopy; Drug development; spatial discrimination; Drug screening; Regression analysis; I.R. radiation; microencapsulation; Quantitation; Drugs DO - http://dx.doi.org/10.1080/02652040601034963 ER - TY - JOUR T1 - Vancomycin-Resistant Lactococcus lactis 1A-1 Isolated from a Competitive Exclusion Product Transfers Vancomycin Resistance Genes to Staphylococcus aureus AN - 20051022; 8360124 AB - A vancomycin-resistant Lactococcus lactis isolate 1A-1 from a competitive exclusion (CE) product contained plasmid-encoded vanA, B, C1, and C2/3 genes. The L. lactis 1A-1 conjugatively transferred the genes to Staphylococcus aureus in vitro. CE product bacteria may be reservoirs for dissemination of vanA, B, and C genes to the human gastrointestinal microbiota. JF - Open Food Science Journal AU - Wagner, RDoug AU - Kurniasih-Rubin, Dedeh AU - Johnson, Shemedia J AD - Division of Microbiology, National Center for Toxicological Research, HFT-250, 3900 NCTR Rd., Jefferson, AR 72022, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 72 EP - 76 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [URL:http://www.bentham.org] VL - 2 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Lactococcus lactis KW - Vancomycin KW - Staphylococcus aureus KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20051022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open+Food+Science+Journal&rft.atitle=Vancomycin-Resistant+Lactococcus+lactis+1A-1+Isolated+from+a+Competitive+Exclusion+Product+Transfers+Vancomycin+Resistance+Genes+to+Staphylococcus+aureus&rft.au=Wagner%2C+RDoug%3BKurniasih-Rubin%2C+Dedeh%3BJohnson%2C+Shemedia+J&rft.aulast=Wagner&rft.aufirst=RDoug&rft.date=2008-01-01&rft.volume=2&rft.issue=&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Open+Food+Science+Journal&rft.issn=1874-2564&rft_id=info:doi/10.2174%2F1874256400802010072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Vancomycin; Lactococcus lactis; Staphylococcus aureus DO - http://dx.doi.org/10.2174/1874256400802010072 ER - TY - JOUR T1 - Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells AN - 19989349; 7944480 AB - Kava (Piper methysticum) is a member of the pepper family and has been cultivated by South Pacific islanders for centuries and used as a social and ceremonial drink. Traditionally, kava extracts are prepared by grinding or chewing the rhizome and mixing with water and coconut milk. The active constituents of kava are a group of approximately 18 compounds collectively referred to as kavalactones or kava pyrones. Kawain, dihydrokawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyangonin are the six major kavalactones. Kava beverages and other preparations are known to be anxiolytic and are used for anxiety disorders. Dietary supplements containing the root of the kava shrub have been implicated in several cases of liver toxicity in humans, including several who required liver transplants after using kava supplements. In order to study the toxicity and mutagenicity, two commercial samples of kava, Kaviar and KavaPure, and the six pure kavalactones including both d-kawain and dl-kawain, were evaluated in L5178Y mouse lymphoma cells. Neither the kava samples nor the kavalactones induced a mutagenic response in the L5178Y mouse lymphoma mutation assay with the addition of human liver S9 activation. JF - Food and Chemical Toxicology AU - Whittaker, P AU - Clarke, J J AU - San, RHC AU - Betz, J M AU - Seifried, HE AU - de Jager, LS AU - Dunkel, V C AD - Food and Drug Administration, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, United States, paul.whittaker@fda.hhs.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 168 EP - 174 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 1 SN - 0278-6915, 0278-6915 KW - Genetics Abstracts; Immunology Abstracts; Toxicology Abstracts KW - Shrubs KW - Mutagenicity KW - Chewing KW - Milk KW - Beverages KW - Anxiety KW - Rhizomes KW - Point mutation KW - Roots KW - Toxicity KW - Liver transplantation KW - Anxiolytics KW - Mammalian cells KW - Dietary supplements KW - Piper methysticum KW - Allografts KW - Liver KW - Lymphoma KW - F 06955:Immunomodulation & Immunopharmacology KW - G 07800:Plants and Algae KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19989349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Evaluation+of+commercial+kava+extracts+and+kavalactone+standards+for+mutagenicity+and+toxicity+using+the+mammalian+cell+gene+mutation+assay+in+L5178Y+mouse+lymphoma+cells&rft.au=Whittaker%2C+P%3BClarke%2C+J+J%3BSan%2C+RHC%3BBetz%2C+J+M%3BSeifried%2C+HE%3Bde+Jager%2C+LS%3BDunkel%2C+V+C&rft.aulast=Whittaker&rft.aufirst=P&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2007.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Shrubs; Mutagenicity; Beverages; Milk; Chewing; Anxiety; Rhizomes; Point mutation; Roots; Toxicity; Liver transplantation; Anxiolytics; Mammalian cells; Dietary supplements; Allografts; Liver; Lymphoma; Piper methysticum DO - http://dx.doi.org/10.1016/j.fct.2007.07.013 ER - TY - JOUR T1 - A new classification system for bacterial Rieske non-heme iron aromatic ring-hydroxylating oxygenases AN - 19900746; 8522270 AB - Background Rieske non-heme iron aromatic ring-hydroxylating oxygenases (RHOs) are multi-component enzyme systems that are remarkably diverse in bacteria isolated from diverse habitats. Since the first classification in 1990, there has been a need to devise a new classification scheme for these enzymes because many RHOs have been discovered, which do not belong to any group in the previous classification. Here, we present a scheme for classification of RHOs reflecting new sequence information and interactions between RHO enzyme components. Result We have analyzed a total of 130 RHO enzymes in which 25 well-characterized RHO enzymes were used as standards to test our hypothesis for the proposed classification system. From the sequence analysis of electron transport chain (ETC) components of the standard RHOs, we extracted classification keys that reflect not only the phylogenetic affiliation within each component but also relationship among components. Oxygenase components of standard RHOs were phylogenetically classified into 10 groups with the classification keys derived from ETC components. This phylogenetic classification scheme was converted to a new systematic classification consisting of 5 distinct types. The new classification system was statistically examined to justify its stability. Type I represents two-component RHO systems that consist of an oxygenase and an FNR sub(C)-type reductase. Type II contains other two-component RHO systems that consist of an oxygenase and an FNR sub(N)-type reductase. Type III represents a group of three-component RHO systems that consist of an oxygenase, a [2Fe-2S]-type ferredoxin and an FNR sub(N)-type reductase. Type IV represents another three-component systems that consist of oxygenase, [2Fe-2S]-type ferredoxin and GR-type reductase. Type V represents another different three-component systems that consist of an oxygenase, a [3Fe-4S]-type ferredoxin and a GR-type reductase. Conclusion The new classification system provides the following features. First, the new classification system analyzes RHO enzymes as a whole. RwithSecond, the new classification system is not static but responds dynamically to the growing pool of RHO enzymes. Third, our classification can be applied reliably to the classification of incomplete RHOs. Fourth, the classification has direct applicability to experimental work. Fifth, the system provides new insights into the evolution of RHO systems based on enzyme interaction. JF - BMC Biochemistry AU - Kweon, Ohgew AU - Kim, Seong-Jae AU - Baek, Songjoon AU - Chae, Jong-Chan AU - Adjei, Michael D AU - Baek, Dong-Heon AU - Kim, Young-Chang AU - Cerniglia, Carl E AD - Microbiology Division, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, USA, oh-gew.kweon@fda.hhs.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 11 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Phylogeny KW - Classification systems KW - Bacteria KW - Enzymes KW - Habitat KW - Ferredoxin KW - Keys KW - reductase KW - Classification KW - Iron KW - Oxygenase KW - Evolution KW - Aromatics KW - Electron transport chain KW - J 02310:Genetics & Taxonomy KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19900746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Biochemistry&rft.atitle=A+new+classification+system+for+bacterial+Rieske+non-heme+iron+aromatic+ring-hydroxylating+oxygenases&rft.au=Kweon%2C+Ohgew%3BKim%2C+Seong-Jae%3BBaek%2C+Songjoon%3BChae%2C+Jong-Chan%3BAdjei%2C+Michael+D%3BBaek%2C+Dong-Heon%3BKim%2C+Young-Chang%3BCerniglia%2C+Carl+E&rft.aulast=Kweon&rft.aufirst=Ohgew&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=BMC+Biochemistry&rft.issn=1471-2091&rft_id=info:doi/10.1186%2F1471-2091-9-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Classification systems; Phylogeny; Enzymes; Habitat; Ferredoxin; Keys; reductase; Classification; Oxygenase; Iron; Aromatics; Evolution; Electron transport chain; Bacteria DO - http://dx.doi.org/10.1186/1471-2091-9-11 ER - TY - JOUR T1 - An investigation of hand forces and postures for using selected mechanical pipettes AN - 19804331; 8549446 AB - The present study evaluated thumb, hand forces, wrist, forearm and shoulder postures used for pipetting with three selected mechanical pipettes. Twelve pipette users in a large university health system participated in pipetting simulation in their own laboratories to investigate the effects of pipette type, body posture (standing/seated), sample volume (200/1000 is a subset of L) and pipetting task on the physical risk factors. The thumb and hand forces were measured with 19 Flexiforce(TM) sensors. Wrist and forearm postures were measured with an electrogoniometer and a torsiometer, respectively. Humeral elevation as shoulder postural stress was assessed by observations from videos recorded during pipetting simulation. The study results showed several advantages of using the non-axial pipette over the traditional axial ones. The non-axial pipette was associated with approximately 2-6 times less thumb and hand force than the traditional axial pipettes. In addition, there were approximately 20-30% reductions in ulnar deviation and 30-70% reductions in humeral elevation to operate the non-axial pipette for most of the pipetting actions. One disadvantage of using the non-axial pipette appears to be increased forearm pronation by approximately 100-150% for the entire pipetting cycle, as compared to the axial pipettes. The results of the study may provide useful information regarding design of pipettes for reducing physical risk factors associated with pipetting. Relevance to industry This paper demonstrated hand forces and postures for common pipetting tasks with selected mechanical pipettes. The hand force and postural data for using axial and non-axial pipettes may provide key information for hand injury prevention due to pipetting in the industry. JF - International Journal of Industrial Ergonomics AU - Lu, Ming-Lun AU - James, Tamara AU - Lowe, Brian AU - Barrero, Marisol AU - Kong, Yong-Ku AD - National Institute for Occupational Safety and Health, Taft Laboratories, 4676 Columbia Parkway MS C-24, Cincinnati, OH 45226, USA, mlu@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 18 EP - 29 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 38 IS - 1 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Sensors KW - Injuries KW - prevention KW - Ergonomics KW - Stress KW - Simulation KW - Working conditions KW - Occupational health KW - posture KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19804331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=An+investigation+of+hand+forces+and+postures+for+using+selected+mechanical+pipettes&rft.au=Lu%2C+Ming-Lun%3BJames%2C+Tamara%3BLowe%2C+Brian%3BBarrero%2C+Marisol%3BKong%2C+Yong-Ku&rft.aulast=Lu&rft.aufirst=Ming-Lun&rft.date=2008-01-01&rft.volume=38&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2007.08.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - posture; Occupational health; Working conditions; Simulation; prevention; Ergonomics; Stress; Injuries; Sensors DO - http://dx.doi.org/10.1016/j.ergon.2007.08.006 ER - TY - JOUR T1 - Asthma arising in flavoring-exposed food production workers AN - 19803739; 8572082 AB - Objectives: While working for a small family-owned popcorn popping company, all of the three non-smoking workers developed a respiratory disease. Because of the newly identified associations between the flavoring chemicals and bronchiolitis obliterans, the specifics of these cases and their exposures were investigated to add to the body of knowledge of flavoring-related lung disease. Materials and Methods: We obtained data on work processes as well as full-shift personal and area air samples for diacetyl, acetoin, 2-nonanone, acetaldehyde, and total volatile organic compounds. Air samples were collected on thermal desorption tubes for analysis by gas chromatography mass spectrometry. We also reviewed medical records and conducted interview with the workers. Results: Air samples representative of the exposures that exacerbated asthma symptoms in two workers contained many different aldehydes. The data from interview and medical records and the high resolution computed tomograms of the chest indicated the presence of occupational asthma in all the three workers and possible bronchiolitis obliterans in two of them. This case series emphasizes a need for exposure reduction and medical surveillance among workers exposed to flavoring chemicals, and provides evidence for an increased risk of occupational asthma, as well as bronchiolitis obliterans, in flavoring-exposed workers. JF - International Journal of Occupational Medicine and Environmental Health AU - Sahakian, N AU - Kullman, G AU - Lynch, D AU - Kreiss, K AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Suite H2800, Morgantown, West Virginia, USA, 26505, KKreiss@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 173 EP - 177 VL - 21 IS - 2 SN - 1232-1087, 1232-1087 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Food KW - Acetaldehyde KW - Mass spectrometry KW - Flavorings KW - Respiratory diseases KW - Chest KW - Mass spectroscopy KW - Workers KW - occupational diseases KW - Gas chromatography KW - Air sampling KW - bronchiolitis obliterans KW - Occupational exposure KW - Data processing KW - Desorption KW - Acetoin KW - medical records KW - Lung diseases KW - Asthma KW - Diacetyl KW - Lung KW - Reviews KW - volatile organic compounds KW - Aldehydes KW - Volatile organic compounds KW - R2 23080:Industrial and labor KW - X 24320:Food Additives & Contaminants KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19803739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Occupational+Medicine+and+Environmental+Health&rft.atitle=Asthma+arising+in+flavoring-exposed+food+production+workers&rft.au=Sahakian%2C+N%3BKullman%2C+G%3BLynch%2C+D%3BKreiss%2C+K&rft.aulast=Sahakian&rft.aufirst=N&rft.date=2008-01-01&rft.volume=21&rft.issue=2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Occupational+Medicine+and+Environmental+Health&rft.issn=12321087&rft_id=info:doi/10.2478%2Fv10001-008-0019-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Desorption; Data processing; Acetoin; medical records; Acetaldehyde; Food; Lung diseases; Asthma; Flavorings; Chest; Diacetyl; Mass spectroscopy; Workers; Gas chromatography; Reviews; volatile organic compounds; bronchiolitis obliterans; Aldehydes; Occupational exposure; Chemicals; Mass spectrometry; Respiratory diseases; occupational diseases; Lung; Air sampling; Volatile organic compounds DO - http://dx.doi.org/10.2478/v10001-008-0019-1 ER - TY - JOUR T1 - Oxidative and molecular interactions of multi-wall carbon nanotubes (MWCNT) in normal and malignant human mesothelial cells AN - 19792685; 8493289 AB - Carbon nanotubes are new tools in industry and medicine with their potential applications in many uses. Multiwall carbon nanotubes (MWCNT) with their morphologic similarity to asbestos and wide commercial and biomedical applications necessitate these investigations. The present study investigated the biological reactivity of MWCNT in normal (NM) and malignant (MM) mesothelial cells. MWCNT containing low iron content generated only negligible amounts of reactive oxygen species with both cells. Exposure of both cell types to MWCNT caused cell death, cytotoxicity, DNA damage and apoptosis, which were greater in MM cells. Exposure of both cells to MWCNT caused a parallel activation of two important transcription factors, phosphorylation of H2AX, and PARP activation which were greater in NM cells. Phosphorylation of ERK1/2 and p38 was greater in MM cells than in NM cells. These findings demonstrate that MWCNT are biologically potent activators of molecular events in NM cells associated with mesothelioma development. JF - Nanotoxicology AU - Pacurari, M AU - Yin, X J AU - Ding, M AU - Leonard, S S AU - Schwegler-Berry, D AU - Ducatman, B S AU - Chirila, M AU - Endo, M AU - Castranova, V AU - Vallyathan, V AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 155 EP - 170 VL - 2 IS - 3 SN - 1743-5390, 1743-5390 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Asbestos KW - Apoptosis KW - Extracellular signal-regulated kinase KW - DNA damage KW - Cytotoxicity KW - Carbon KW - Reactive oxygen species KW - Phosphorylation KW - Poly(ADP-ribose) polymerase KW - Transcription factors KW - mesothelioma KW - nanotubes KW - Iron KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19792685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Oxidative+and+molecular+interactions+of+multi-wall+carbon+nanotubes+%28MWCNT%29+in+normal+and+malignant+human+mesothelial+cells&rft.au=Pacurari%2C+M%3BYin%2C+X+J%3BDing%2C+M%3BLeonard%2C+S+S%3BSchwegler-Berry%2C+D%3BDucatman%2C+B+S%3BChirila%2C+M%3BEndo%2C+M%3BCastranova%2C+V%3BVallyathan%2C+V&rft.aulast=Pacurari&rft.aufirst=M&rft.date=2008-01-01&rft.volume=2&rft.issue=3&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.1080%2F17435390802318356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Asbestos; Apoptosis; DNA damage; Extracellular signal-regulated kinase; Cytotoxicity; Carbon; Phosphorylation; Reactive oxygen species; Transcription factors; Poly(ADP-ribose) polymerase; nanotubes; mesothelioma; Iron DO - http://dx.doi.org/10.1080/17435390802318356 ER - TY - JOUR T1 - The change in weight perception of weight status among the overweight: comparison of NHANES III (1988-1994) and 1999-2004 NHANES AN - 19725741; 9042745 AB - Objectives This study seeks to determine whether perception of weight status among the overweight has changed with the increasing overweight/obesity prevalence. Methods The perception of weight status was compared between overweight participants (BMI between 25.0-29.9 kg/m super(2)) from NHANES III (1988-1994) and overweight participants from NHANES 1999-2004. Perception of weight status was assessed by asking participants to classify their weight as about the right weight, underweight or overweight. Comparisons were made across age groups, genders, race/ethnicities and various income levels. Results Fewer overweight people during the NHANES 1999-2004 survey perceived themselves as overweight when compared to overweight people during the NHANES III survey. The change in distortion between the survey periods was greatest among persons with lower income, males and African-Americans. Conclusion The increase in overweight/obesity between the survey years (NHANES III and NHANES 1999-2004 has been accompanied with fewer overweight people perceiving themselves as overweight. JF - International Journal of Behavioral Nutrition and Physical Activity AU - Johnson-Taylor, Wendy L AU - Fisher, Rachel A AU - Hubbard, Van S AU - Starke-Reed, Pamela AU - Eggers, Paul S AD - US Department of Health and Human Services, National Institutes of Health, Division of Nutrition Research Coordination, Bethesda, MD, USA, wj50v@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 9 PB - BioMed Central Ltd., Middlesex House VL - 5 SN - 1479-5868, 1479-5868 KW - Physical Education Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19725741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.atitle=The+change+in+weight+perception+of+weight+status+among+the+overweight%3A+comparison+of+NHANES+III+%281988-1994%29+and+1999-2004+NHANES&rft.au=Johnson-Taylor%2C+Wendy+L%3BFisher%2C+Rachel+A%3BHubbard%2C+Van+S%3BStarke-Reed%2C+Pamela%3BEggers%2C+Paul+S&rft.aulast=Johnson-Taylor&rft.aufirst=Wendy&rft.date=2008-01-01&rft.volume=5&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.issn=14795868&rft_id=info:doi/10.1186%2F1479-5868-5-9 LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1186/1479-5868-5-9 ER - TY - JOUR T1 - Racial/Ethnic Minority Children's Use of Psychiatric Emergency Care in California's Public Mental Health System AN - 19716016; 7932432 AB - OBJECTIVES: We examined rates and intensity of crisis services use by race/ethnicity for 351174 children younger than 18 years who received specialty mental health care from California's 57 county public mental health systems between July 1998 and June 2001. METHODS: We used fixed-effects regression for a controlled assessment of racial/ethnic disparities in children's use of hospital-based services for the most serious mental health crises (crisis stabilization services) and community-based services for other crises (crisis intervention services). RESULTS: African American children were more likely than were White children to use both kinds of crisis care and made more visits to hospital-based crisis stabilization services after initial use. Asian American/Pacific Islander and American Indian/Alaska Native children were more likely than were White children to use hospital-based crisis stabilization services but, along with Latino children, made fewer hospital-based crisis stabilization visits after an initial visit. CONCLUSIONS: African American children used both kinds of crisis services more than did White children, and Asian Americans/Pacific Islander and American Indians/Alaska Native children visited only when they experienced the most disruptive and troubling kind of crises, and made nonrecurring visits. JF - American Journal of Public Health AU - Snowden, Lonnie R AU - Masland, Mary C AU - Libby, Anne M AU - Wallace, Neal AU - Fawley, Kya AD - Lonnie R. Snowden, Mary C. Masland, and Kya Fawley are with the Center for Mental Health Services Research, School of Social Welfare, University of California, Berkeley. Anne M. Libby is with the Department of Psychiatry, School of Medicine, University of Colorado, Denver, and Health Sciences Center, Denver. Neal Wallace is with the Mark O. Hatfield School of Government, Portland State University, Portland, Ore Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 118 EP - 124 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 98 IS - 1 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts KW - Health care KW - INE, USA, California KW - crisis intervention KW - INE, USA, Alaska KW - Children KW - community involvement KW - Ethnic groups KW - Public health KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19716016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Racial%2FEthnic+Minority+Children%27s+Use+of+Psychiatric+Emergency+Care+in+California%27s+Public+Mental+Health+System&rft.au=Snowden%2C+Lonnie+R%3BMasland%2C+Mary+C%3BLibby%2C+Anne+M%3BWallace%2C+Neal%3BFawley%2C+Kya&rft.aulast=Snowden&rft.aufirst=Lonnie&rft.date=2008-01-01&rft.volume=98&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Health care; crisis intervention; Children; community involvement; Ethnic groups; Public health; INE, USA, California; INE, USA, Alaska ER - TY - JOUR T1 - Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections AN - 19715391; 8568580 AB - Infections with antimicrobial-resistant bacteria are a great challenge in both human and veterinary medicine. The purpose of this study was to determine antimicrobial susceptibility of 106 strains of Pseudomonas aeruginosa isolated from dogs with otitis and pyoderma from 2003 to 2006 in the United States. Three antimicrobial panels, including 6 classes and 32 antimicrobial agents, were used. A wide range of susceptibility patterns were noted with some isolates being resistant to between 8 and 28 (mean 16) of the antimicrobials tested. Among the b-lactams, all isolates were resistant to ampicillin, cefoxitin, cefpodoxime, cephalothin and cefazolin followed by amoxicillin/clavulanic acid (99%), ceftiofur (97%), ceftriaxone (39%), cefotaxime (26%), and cefotaxime/clavulanic acid (20%), whereas less than 7% of isolates were resistant to ceftazidime/clavulanic acid, ceftazidime, piperacillin/tazobactam or cefepime. Two isolates were resistant to the carbapenems. Among the quinolones and fluoroquinolones, the most isolates were resistant to naladixic acid (96%), followed by orbifloxacin (52%), difloxacin (43%), enrofloxacin (31%), marbofloxacin (27%), gatifloxacin (23%), levofloxacin (21%), and ciprofloxacin (16%). Among the aminoglycosides, the most resistance was seen to kanamycin (90%), followed by streptomycin (69%), gentamicin (7%), and amikacin (3%). Of the remaining antimicrobials 100% of the isolates were resistant to chloramphenicol followed by tetracycline (98%), trimethoprim/sulfamethoxazole (57%), and sulfisoxazole (51%). Point mutations were present in gyrA, gyrB, parC, and/or parE genes among 34 of the 102 naladixic acid-resistant isolates. Two isolates contained class 1 integrons carrying aadA gene conferring streptomycin and spectinomycin resistance. The findings suggest that many antimicrobial agents commonly used in companion animals may not constitute appropriate therapy for canine pseudomonas infections. JF - Veterinary Microbiology AU - Rubin, J AU - Walker, R D AU - Blickenstaff, K AU - Bodeis-Jones, S AU - Zhao, S AD - Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon S7N 5B4, Canada, shaohua.zhao@FDA.HHS.GOV Y1 - 2008 PY - 2008 DA - 2008 SP - 164 EP - 172 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 131 IS - 1-2 SN - 0378-1135, 0378-1135 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Pseudomonas aeruginosa KW - Antimicrobial resistance KW - Fluoroquinolones KW - Canine KW - Class 1 integron KW - QRDR KW - Trimethoprim KW - Amikacin KW - Difloxacin KW - Drug resistance KW - Levofloxacin KW - Quinolones KW - Streptomycin KW - Infection KW - Cefpodoxime KW - DNA topoisomerase IV KW - Ceftazidime KW - Ciprofloxacin KW - Clavulanic acid KW - Pyoderma KW - Cefoxitin KW - Chloramphenicol KW - Cefotaxime KW - Sulfamethoxazole KW - DNA topoisomerase KW - b-Lactam antibiotics KW - Tazobactam KW - Ceftriaxone KW - Antimicrobial agents KW - Gatifloxacin KW - Gentamicin KW - Cefazolin KW - Otitis KW - Spectinomycin KW - Piperacillin KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19715391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+Microbiology&rft.atitle=Antimicrobial+resistance+and+genetic+characterization+of+fluoroquinolone+resistance+of+Pseudomonas+aeruginosa+isolated+from+canine+infections&rft.au=Rubin%2C+J%3BWalker%2C+R+D%3BBlickenstaff%2C+K%3BBodeis-Jones%2C+S%3BZhao%2C+S&rft.aulast=Rubin&rft.aufirst=J&rft.date=2008-01-01&rft.volume=131&rft.issue=1-2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Veterinary+Microbiology&rft.issn=03781135&rft_id=info:doi/10.1016%2Fj.vetmic.2008.02.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Trimethoprim; Difloxacin; Amikacin; Levofloxacin; Drug resistance; Quinolones; Streptomycin; Infection; Cefpodoxime; DNA topoisomerase IV; Ceftazidime; Ciprofloxacin; Clavulanic acid; Pyoderma; Cefoxitin; Chloramphenicol; Cefotaxime; Sulfamethoxazole; Fluoroquinolones; b-Lactam antibiotics; DNA topoisomerase; Tazobactam; Ceftriaxone; Gatifloxacin; Antimicrobial agents; Gentamicin; Cefazolin; Otitis; Spectinomycin; Piperacillin; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1016/j.vetmic.2008.02.018 ER - TY - JOUR T1 - Analysis of musculoskeletal loading in an index finger during tapping AN - 19636099; 8793087 AB - Since musculoskeletal disorders of the upper extremities are believed to be associated with repetitive excessive muscle force production in the hands, understanding the time-dependent muscle forces during key tapping is essential for exploring the mechanisms of disease initiation and development. In the current study, we have simulated the time-dependent dynamic loading in the muscle/tendons in an index finger during tapping. The index finger model is developed using a commercial software package AnyBody, and it contains seven muscle/tendons that connect the three phalangeal finger sections. Our simulations indicate that the ratios of the maximal forces in flexor digitorum superficialis (FS) and flexor digitorum profundus (FP) tendons to the maximal force at the fingertip are 0.95 and 2.9, respectively, which agree well with recently published experimental data. The time sequence of the finger muscle activation predicted in the current study is consistent with the EMG data in the literature. The proposed model will be useful for bioengineers and ergonomic designers to improve keyboard design minimizing musculoskeletal loadings in the fingers. JF - Journal of Biomechanics AU - Wu, John Z AU - An, Kai-Nan AU - Cutlip, Robert G AU - Krajnak, Kristine AU - Welcome, Daniel AU - Dong, Ren G AD - National Institute for Occupational Safety and Health, NIOSH/CDC, 1095 Willowdale Road, MS-2027, Morgantown, WV 26505, USA, jwu@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 668 EP - 676 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 41 IS - 3 SN - 0021-9290, 0021-9290 KW - Health & Safety Science Abstracts KW - Index finger KW - Muscle force KW - Muscle-tendon excursion KW - Tapping KW - Simulations KW - biomechanics KW - Muscles KW - Simulation KW - musculoskeletal system KW - Ergonomics KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19636099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Analysis+of+musculoskeletal+loading+in+an+index+finger+during+tapping&rft.au=Wu%2C+John+Z%3BAn%2C+Kai-Nan%3BCutlip%2C+Robert+G%3BKrajnak%2C+Kristine%3BWelcome%2C+Daniel%3BDong%2C+Ren+G&rft.aulast=Wu&rft.aufirst=John&rft.date=2008-01-01&rft.volume=41&rft.issue=3&rft.spage=668&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/10.1016%2Fj.jbiomech.2007.09.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - biomechanics; Muscles; Simulation; Ergonomics; musculoskeletal system DO - http://dx.doi.org/10.1016/j.jbiomech.2007.09.025 ER - TY - JOUR T1 - Tracking the prevalence of rollover protective structures on U.S. farm tractors: 1993, 2001, and 2004 AN - 19626810; 8770130 AB - Problem - Between 1992 and 2005, 1412 workers on farms died from tractor overturns. A Rollover Protective Structure (ROPS) is a proven intervention to reduce overturn deaths. However, farm characteristics that are associated with the adoption of ROPS are not well understood. Methods - ROPS prevalence statistics were derived from National Institute for Occupational Safety and Health (NIOSH) surveys that tracked ROPS use on farms. Data were from the years 1993, 2001, and 2004. Results - In 1993, 38% of tractors were equipped with ROPS. This increased to 51% by 2004. ROPS prevalence rates were higher on farms in the Southern region of the United States, on farms where the operator was 25-34 years old, and on farms with $100,000 or more of farm sales. Low ROPS prevalence rates were associated with farm operators 65 years old or older and with farms with less than $10,000 of farm product sales. Summary - The increase in ROPS prevalence between 1993 and 2004 has not been sufficient to decrease the rate of tractor overturn deaths on farms. Incentive programs targeting older farm operators and low-income farm operations are suggested to increase ROPS use on tractors. Impact on Industry - The study provides farm characteristics associated with low ROPS prevalence rates. The results can be used to target farms for future ROPS promotion activities. JF - Journal of Safety Research AU - Loringer, Kelly A AU - Myers, John R AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA, JrMyers@cdc.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 509 EP - 517 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 5 SN - 0022-4375, 0022-4375 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Occupational safety KW - Socioeconomics KW - intervention KW - farms KW - rollover KW - Mortality KW - USA KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19626810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Tracking+the+prevalence+of+rollover+protective+structures+on+U.S.+farm+tractors%3A+1993%2C+2001%2C+and+2004&rft.au=Loringer%2C+Kelly+A%3BMyers%2C+John+R&rft.aulast=Loringer&rft.aufirst=Kelly&rft.date=2008-01-01&rft.volume=39&rft.issue=5&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2008.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; farms; Mortality; rollover; Socioeconomics; Occupational safety; intervention DO - http://dx.doi.org/10.1016/j.jsr.2008.08.003 ER - TY - JOUR T1 - Childhood overweight and obesity: is the gap closing the wrong way? AN - 19602419; 8201788 AB - BACKGROUND: Obesity is a significant public health issue. Obese children have an increased risk of developing chronic adult diseases. Knowledge of socio-economic distribution trends in childhood overweight/obesity is limited. METHODS: Body mass indices for 3-year-old children resident in three South Wales localities from 1995 to 2005 were derived from the National Community Child Health Database (NCCHD) and examined in relation to residence lower super output area (LSOA) Townsend Material Deprivation Score. RESULTS: Over 11 years, 53-69% of children had height/weight measurements recorded (with little difference observed across deprivation fifths). Amalgamating the data for all 11 years showed no significant association of prevalence with LSOA socio-economic status. Annual trends varied substantially: the most deprived fifth had the lowest proportion on five, and the highest on six, occasions. Linear regression analysis suggested a greater rate of increase of overweight/obesity in children from most-deprived LSOA areas compared with those from least deprived areas (not statistically significant). CONCLUSIONS: Socio-economic difference in overweight/obesity prevalence lessened between 1995 and 2005. Despite annual variation, this apparent closing of the gap has been the result of an increase in overweight/obesity prevalence in children from the most deprived areas who, initially, had a lower prevalence compared with children from least deprived areas, but by 2005, had overtaken them. JF - Journal of Public Health Medicine AU - Brunt, H AU - Lester, N AU - Davies, G AU - Williams, R AD - National Public Health Service for Wales, St. David's Park, Job's Well Road, Carmarthen SA31 3WY, UK Y1 - 2008 PY - 2008 DA - 2008 SP - 145 EP - 152 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 30 IS - 2 SN - 0957-4832, 0957-4832 KW - Risk Abstracts; Health & Safety Science Abstracts KW - obesity KW - Socioeconomics KW - Public health KW - body mass KW - British Isles, Wales, South Wales KW - annual variations KW - Children KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health+Medicine&rft.atitle=Childhood+overweight+and+obesity%3A+is+the+gap+closing+the+wrong+way%3F&rft.au=Brunt%2C+H%3BLester%2C+N%3BDavies%2C+G%3BWilliams%2C+R&rft.aulast=Brunt&rft.aufirst=H&rft.date=2008-01-01&rft.volume=30&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health+Medicine&rft.issn=09574832&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - British Isles, Wales, South Wales; obesity; Children; Socioeconomics; Public health; annual variations; body mass ER - TY - JOUR T1 - Issues When Modeling Benzene, Toluene, and Xylene Exposures Using a Literature Database AN - 19539753; 8502026 AB - A database of benzene, toluene, and xylene measurements was compiled from an extensive literature review that contained information on several exposure determinants, including job type, operation, mechanism of release, process type, ventilation, temperature, distance from the source, quantity, and location. The database was used to develop statistical models for benzene, toluene, and xylene exposure as a function of operation and other workplace determinants. These models can be used to predict exposure levels for subjects enrolled in community-based case-control studies. This article presents the derived parameter estimates for specific operations and additional workplace exposure determinants and describes a number of statistical and data limitation issues that are inherent in determinants modeling of historical published data. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resource(s): a PDF file of QQ plots and a Word file with references used in the benzene/toluene/xylene exposure database.] JF - Journal of Occupational and Environmental Hygiene AU - Hein, Misty J AU - Waters, Martha A AU - van Wijngaarden, Edwin AU - Deddens, James A AU - Stewart, Patricia A AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 36 EP - 47 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 1 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Historical account KW - Statistics KW - Ventilation KW - Toluene KW - Statistical analysis KW - Benzene KW - Models KW - Xylene KW - Occupational exposure KW - Environmental hygiene KW - Temperature effects KW - Data processing KW - Mathematical models KW - Temperature KW - community involvement KW - Databases KW - Reviews KW - Hygiene KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19539753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Issues+When+Modeling+Benzene%2C+Toluene%2C+and+Xylene+Exposures+Using+a+Literature+Database&rft.au=Hein%2C+Misty+J%3BWaters%2C+Martha+A%3Bvan+Wijngaarden%2C+Edwin%3BDeddens%2C+James+A%3BStewart%2C+Patricia+A&rft.aulast=Hein&rft.aufirst=Misty&rft.date=2008-01-01&rft.volume=5&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701763947 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Mathematical models; Data processing; Statistics; Ventilation; Toluene; Statistical analysis; Benzene; Models; Databases; Xylene; Reviews; Occupational exposure; Environmental hygiene; Historical account; Temperature; Hygiene; community involvement DO - http://dx.doi.org/10.1080/15459620701763947 ER - TY - JOUR T1 - Hearing Difficulty Attributable to Employment by Industry and Occupation: An Analysis of the National Health Interview Survey-- United States, 1997 to 2003 AN - 19528901; 8113439 AB - Objective: To estimate the national burden of hearing difficulty among workers in US industries and occupations. Methods: Data on 130,102 employed National Health Interview Survey respondents between the ages of 18 to 65 years who were interviewed between 1997 and 2003 were analyzed to estimate the population prevalence, adjusted prevalence ratios, and fractions of hearing difficulty attributable to employment. Results: The estimated population prevalence of hearing difficulty was 11.4% (24% attributable to employment). The adjusted prevalence ratios of hearing difficulty were highest for railroads, mining, and primary metal manufacturing industry. Occupations with increased risk of hearing difficulty were mechanics/repairers, machine operators, and transportation equipment operators. Conclusions: Hearing difficulty was differentially distributed across various industries. In industries with high rates, employers and workers should take preventive action to reduce the risk of occupational hearing loss. JF - Journal of Occupational and Environmental Medicine AU - Tak, S AU - Calvert, G M AD - Surveillance Branch, Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-17, Cincinnati, OH 45226, USA, stak@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 46 EP - 56 VL - 50 IS - 1 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - risk reduction KW - Transportation KW - Railroads KW - Metals KW - Noise levels KW - Hearing loss KW - Mining KW - Manufacturing industry KW - Age KW - Occupational exposure KW - USA KW - R2 23080:Industrial and labor KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19528901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Hearing+Difficulty+Attributable+to+Employment+by+Industry+and+Occupation%3A+An+Analysis+of+the+National+Health+Interview+Survey--+United+States%2C+1997+to+2003&rft.au=Tak%2C+S%3BCalvert%2C+G+M&rft.aulast=Tak&rft.aufirst=S&rft.date=2008-01-01&rft.volume=50&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181579316 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Hearing loss; risk reduction; Railroads; Metals; Noise levels; Occupational exposure; Transportation; Manufacturing industry; Mining; Age DO - http://dx.doi.org/10.1097/JOM.0b013e3181579316 ER - TY - JOUR T1 - Antimicrobial Resistance Genes Associated with Salmonella enterica Serovar Newport Isolates from Food Animals AN - 19526802; 7932106 AB - Salmonella enterica serotype Newport is an important cause of salmonellosis, with strains increasingly being resistant to multiple antimicrobial agents. The increase is associated with the acquisition of multiple resistance genes. This study characterizes the genetic basis of resistance of serotype Newport isolates collected from veterinary sources by PCR and DNA sequencing analysis. JF - Antimicrobial Agents & Chemotherapy AU - Lynne, Aaron M AU - Rhodes-Clark, Bobbie S AU - Bliven, Kimberly AU - Zhao, Shaohua AU - Foley, Steven L AD - National Farm Medicine Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449. Department of Biology, University of Central Arkansas, Conway, Arkansas 72035. Division of Animal and Food Microbiology, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 353 EP - 356 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - DNA sequencing KW - Serotypes KW - Salmonella enterica KW - Drug resistance KW - Food KW - Salmonellosis KW - Polymerase chain reaction KW - Antimicrobial agents KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19526802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Antimicrobial+Resistance+Genes+Associated+with+Salmonella+enterica+Serovar+Newport+Isolates+from+Food+Animals&rft.au=Lynne%2C+Aaron+M%3BRhodes-Clark%2C+Bobbie+S%3BBliven%2C+Kimberly%3BZhao%2C+Shaohua%3BFoley%2C+Steven+L&rft.aulast=Lynne&rft.aufirst=Aaron&rft.date=2008-01-01&rft.volume=52&rft.issue=1&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA sequencing; Serotypes; Salmonellosis; Food; Drug resistance; Polymerase chain reaction; Antimicrobial agents; Salmonella enterica ER - TY - JOUR T1 - The suicide mortality of working physicians and dentists AN - 19522441; 7936933 AB - BACKGROUND: Some studies have shown that physicians and dentists have elevated risks of suicide, while other studies have not. Aims Using all deaths and corresponding census data in 26 US states, we examine the suicide risk for working physicians and dentists. METHODS: Death and census data for working people were obtained from 1984 through 1992. Directly age-standardized suicide rate ratios (SRRs) were calculated for white male and white female physicians and white male dentists. RESULTS: For white female physicians, the suicide rate was elevated compared to the working US population (SRR = 2.39, 95% CI = 1.52-3.77). For white male physicians and dentists, the overall suicide rates were reduced (SRR = 0.80, 95% CI = 0.53-1.20 and 0.68, 95% CI = 0.52-0.89, respectively). For older white male physicians and dentists, however, observed suicide rates were elevated. CONCLUSIONS: White female physicians have an elevated suicide rate. Only older white male physicians and dentists have elevated suicide rates, which partially explains the varied conclusions in the literature. JF - Occupational Medicine AU - Petersen, Martin R AU - Burnett, Carol A AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 25 EP - 29 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 58 IS - 1 SN - 0962-7480, 0962-7480 KW - Risk Abstracts; Health & Safety Science Abstracts KW - census KW - Mortality KW - suicide KW - Working conditions KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19522441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+Medicine&rft.atitle=The+suicide+mortality+of+working+physicians+and+dentists&rft.au=Petersen%2C+Martin+R%3BBurnett%2C+Carol+A&rft.aulast=Petersen&rft.aufirst=Martin&rft.date=2008-01-01&rft.volume=58&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Occupational+Medicine&rft.issn=09627480&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - census; Mortality; Working conditions; suicide; Occupational health ER - TY - JOUR T1 - In Vitro Evaluation of the Protective Role of Human Antibodies to West Nile Virus (WNV) Produced during Natural WNV Infection AN - 19488016; 8585599 AB - Background. West Nile virus (WNV) is endemic in the United States and transmissible by transfusion. Since 2003, the US blood supply has been screened by nucleic-acid tests (NAT) for WNV in minipools (MP-NAT) of 6 or 16 specimens. WNV infection begins with low-level viremia detectable only by individual testing (ID-NAT) and no detectable WNV antibodies. Viremia then increases to levels detectable by MP-NAT, and antibodies become detectable; later, viremia decays to levels detectable only by ID-NAT before becoming undetectable. All but 1 documented WNV transmission by transfusion involved blood components negative for WNV antibodies, raising the question whether WNV antibody-positive blood components with low levels of WNV RNA are infectious. Methods. Specimens from 102 viremic donors with and without WNV antibodies were used to investigate infectivity in cultures of Vero cells and human monocyte-derived macrophages (MDMs). Results. In Vero cell culture, 54 (74%) of 73 WNV antibody-negative specimens and 10 (36%) of 28 WNV antibody- positive specimens were infectious. In a random subset of 20 specimens tested in MDM culture, 7 (88%) of 8 WNV antibody-positive specimens and 12 (100%) of 12 WNV antibody-negative specimens were infectious. Conclusion. WNV antibodies do not always protect susceptible cells from WNV infection in vitro. RNA positivity in the presence of antibody cannot be ignored as a theoretical risk for blood recipients and needs further investigation. JF - Journal of Infectious Diseases AU - Rios, M AU - Daniel, S AU - Dayton, AI AU - Wood, O AU - Hewlett, I K AU - Epstein, J S AU - Caglioti, S AU - Stramer, S L AD - Laboratory of Molecular Virology-Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, and American Red Cross, Gaithersburg, Maryland, Maria.Rios@fda.hhs.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 1300 EP - 1308 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu] VL - 198 IS - 9 SN - 0022-1899, 0022-1899 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts; Virology & AIDS Abstracts KW - Macrophages KW - Human diseases KW - Vero cells KW - Cell culture KW - Infection KW - Transfusion KW - Disease transmission KW - Public health KW - Blood KW - USA KW - Infectivity KW - Antibodies KW - Endemic species KW - RNA KW - Viral diseases KW - Infectious diseases KW - Viremia KW - Monocytes KW - West Nile virus KW - V 22350:Immunology KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19488016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=In+Vitro+Evaluation+of+the+Protective+Role+of+Human+Antibodies+to+West+Nile+Virus+%28WNV%29+Produced+during+Natural+WNV+Infection&rft.au=Rios%2C+M%3BDaniel%2C+S%3BDayton%2C+AI%3BWood%2C+O%3BHewlett%2C+I+K%3BEpstein%2C+J+S%3BCaglioti%2C+S%3BStramer%2C+S+L&rft.aulast=Rios&rft.aufirst=M&rft.date=2008-01-01&rft.volume=198&rft.issue=9&rft.spage=1300&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F592277 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Endemic species; Human diseases; Antibodies; Infectious diseases; Viral diseases; Public health; Disease transmission; Blood; Infectivity; RNA; Vero cells; Cell culture; Monocytes; Viremia; Transfusion; Infection; West Nile virus; USA DO - http://dx.doi.org/10.1086/592277 ER - TY - JOUR T1 - Compact and portable digitally controlled device for testing footwear materials: Technical note AN - 19425756; 8833338 AB - Little or no practical decision-making data are available to the foot-care provider regarding the selection of orthotic materials used in therapeutic footwear. A device for simulating in-shoe forefoot conditions for the testing of ortho-sis materials is described. Materials are tested for their effectiveness by evaluating and comparing stress-strain and dynamic compression fatigue characteristics. The device, called the Cyclical Compression Tester (CCT), has been optimized for size, simplicity of construction, and cost. Application of the device ranges from the clinician deciding the useful life of single- and multidensity orthosis materials to the researcher characterizing materials for finite-element analysis modeling. This real-time CCT device and custom user interface combine to make an evaluation tool useful for testing how the pressure distribution of in-shoe materials changes over time in therapeutic footwear for those with peripheral neuropathy at risk for foot injury. JF - Journal of Rehabilitation Research and Development AU - Foto, J G AD - National Hansen's Disease Programs, Paul W. Brand Biomechanics Laboratory, 1770 Physicians Park Dr, Baton Rouge, LA 70816, USA, jfoto@hrsa.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 893 EP - 900 VL - 45 IS - 6 SN - 0748-7711, 0748-7711 KW - Physical Education Index KW - Evaluation KW - Fatigue KW - Feet KW - Injuries KW - Analysis KW - Stress KW - Orthotics KW - Shoes KW - Modeling KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19425756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Compact+and+portable+digitally+controlled+device+for+testing+footwear+materials%3A+Technical+note&rft.au=Foto%2C+J+G&rft.aulast=Foto&rft.aufirst=J&rft.date=2008-01-01&rft.volume=45&rft.issue=6&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2007.07.0111 LA - English DB - Physical Education Index N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Shoes; Orthotics; Modeling; Analysis; Evaluation; Feet; Fatigue; Stress; Injuries DO - http://dx.doi.org/10.1682/JRRD.2007.07.0111 ER - TY - JOUR T1 - A new approach to characterize grip force applied to a cylindrical handle AN - 19419940; 8808321 AB - The grip force applied to a cylindrical handle is a function of the measurement reference axis. So far, however, no attempt has been made to fully describe the exact form of this function. The objectives of this study were to examine some fundamental characteristics of grip forces and to explore the basic pattern of the grip force function. Twenty subjects (10 males and 10 females) participated in the experiment. The subjects alternately used their left and right hands to apply maximum grip forces and medium grip forces (about 40% of maximum) to a 30 mm handle. A flexible pressure sensor mat was used to measure the grip pressure. The pressure was integrated with respect to different measurement axes; this resulted in the grip force function. This study found that every gripping action produces maximum and minimum force axes; these axes are separated by about 90 degree . The maximum force is correlated with the minimum force, but the former is generally about 1.42 times the latter. The principal grip direction is about 78 degree from the z sub(h)-axis of the hand biodynamic coordinate system defined in ISO 8727 [ISO 8727. Mechanical vibration and shock - human exposure - biodynamic coordinate systems. Geneva, Switzerland: International Organization for Standardization; 1997]. More interestingly, each of the 160 sets of experimental data reasonably fit this study's proposed elliptical model. The implications of the findings are discussed. JF - Medical Engineering & Physics AU - Dong, Ren G AU - Wu, John Z AU - Welcome, Daniel E AU - McDowell, Thomas W AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, MS L-2027, WV 26505, USA, rkd6@cdc.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 20 EP - 33 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 1 SN - 1350-4533, 1350-4533 KW - Biotechnology and Bioengineering Abstracts KW - Vibrations KW - Standardization KW - Mathematical models KW - Data processing KW - Shock KW - Grasping KW - International organizations KW - Hand KW - Pressure KW - Models KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19419940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Engineering+%26+Physics&rft.atitle=A+new+approach+to+characterize+grip+force+applied+to+a+cylindrical+handle&rft.au=Dong%2C+Ren+G%3BWu%2C+John+Z%3BWelcome%2C+Daniel+E%3BMcDowell%2C+Thomas+W&rft.aulast=Dong&rft.aufirst=Ren&rft.date=2008-01-01&rft.volume=30&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Medical+Engineering+%26+Physics&rft.issn=13504533&rft_id=info:doi/10.1016%2Fj.medengphy.2007.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Grasping; Pressure; Hand; Vibrations; International organizations; Data processing; Models; Mathematical models; Shock; Standardization DO - http://dx.doi.org/10.1016/j.medengphy.2007.01.002 ER - TY - JOUR T1 - Reduction of Fumonisin B sub(1) in Corn Grits by Single-Screw Extrusion AN - 19298428; 8133999 AB - This study was designed to determine the efficacy of extrusion in reducing fumonisin B sub(1) in corn flaking grits in the presence and absence of glucose. In addition, degradation products of fumonisin B sub(1) during extrusion were identified and quantitated with a mass balance approach. Uncontaminated clean corn grits, grits spiked with 30 kg/g fumonisin B sub(1), and grits fermented with Fusarium verticillioides M-2552 (40-50 kg/g fumonisin B sub(1)) were extruded in the presence and absence of glucose (10%, w/w) using a single-screw extruder. Extrusion decreased fumonisin B sub(1) by 21-37%, whereas the same process with added glucose further decreased fumonisin B sub(1) by 77-87%. LC-fluorescence and LC-MS showed that most fumonisin in the extruded samples without added glucose was the fumonisin B sub(1) form, whereas the main degradation product in grits extruded with glucose was N-(deoxy-D-fructos-1-yl)fumonisin B sub(1). The formation of hydrolyzed fumonisin B sub(1) was not significant during extrusion. Results suggest that extrusion in the presence of glucose may reduce fumonisin B sub(1) in corn grits significantly. KW: Fumonisin; reduction; N-(deoxy-D- fructos-1-yl)fumonisin; extrusion. JF - Journal of Agricultural and Food Chemistry AU - Jablonski, Joseph AU - Jackson, Lauren S AU - Ryu, Dojin AU - Hanna, Milford A AU - Bianchini, Andreia AU - Bullerman, Lloyd B AD - Department of Food Science and Technology, 143 Filley Hall, University of Nebraska, Lincoln, Nebraska 68583; National Center for Food Safety and Technology, U.S. Food and Drug Administration, 6502 South Archer Road, Summit-Argo, Illinois 60501; and Department of Nutrition and Food Sciences, Texas Woman's University, P.O. Box 425888, Denton, Texas 76204 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 2400 EP - 2405 PB - American Chemical Society, [mailto:service@acs.org] VL - 56 IS - 7 SN - 0021-8561, 0021-8561 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Glucose KW - Fumonisin B1 KW - Fusarium verticillioides KW - Degradation products KW - A 01330:Food Microbiology KW - W 30935:Food Biotechnology KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19298428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+and+Food+Chemistry&rft.atitle=Reduction+of+Fumonisin+B+sub%281%29+in+Corn+Grits+by+Single-Screw+Extrusion&rft.au=Jablonski%2C+Joseph%3BJackson%2C+Lauren+S%3BRyu%2C+Dojin%3BHanna%2C+Milford+A%3BBianchini%2C+Andreia%3BBullerman%2C+Lloyd+B&rft.aulast=Jablonski&rft.aufirst=Joseph&rft.date=2008-01-01&rft.volume=56&rft.issue=7&rft.spage=2400&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+and+Food+Chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf0729513 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Glucose; Fumonisin B1; Degradation products; Fusarium verticillioides DO - http://dx.doi.org/10.1021/jf0729513 ER - TY - JOUR T1 - Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells AN - 19288742; 8746616 AB - Introduction Mesenchymal progenitor cells (MPCs) are multipotent progenitor cells in adult tissues, for example, bone marrow (BM). Current challenges of clinical application of BM-derived MPCs include donor site morbidity and pain as well as low cell yields associated with an age-related decrease in cell number and differentiation potential, underscoring the need to identify alternative sources of MPCs. Recently, MPC sources have diversified; examples include adipose, placenta, umbilicus, trabecular bone, cartilage, and synovial tissue. In the present work, we report the presence of MPCs in human tonsillar tissue. Methods We performed comparative and quantitative analyses of BM-MPCs with a subpopulation of adherent cells isolated from this lymphoid tissue, termed tonsil-derived MPCs (T-MPCs). The expression of surface markers was assessed by fluorescent-activated cell sorting analysis. Differentiation potential of T-MPCs was analyzed histochemically and by reverse transcription-polymerase chain reaction for the expression of lineage-related marker genes. The immunosuppressive properties of MPCs were determined in vitro in mixed lymphocyte reactions. Results Surface epitope analysis revealed that T-MPCs were negative for CD14, CD31, CD34, and CD45 expression and positive for CD29, CD44, CD90, and CD105 expression, a characteristic phenotype of BM-MPCs. Similar to BM-MPCs, T-MPCs could be induced to undergo adipogenic differentiation and, to a lesser extent, osteogenic and chondrogenic differentiation. T-MPCs did not express class II major histocompatibility (MHC) antigens, and in a similar but less pronounced manner compared with BM-MPCs, T-MPCs were immunosuppressive, inhibiting the proliferation of T cells stimulated by allogeneic T cells or by non-specific mitogenic stimuli via an indoleamine 2,3-dioxygenase-dependent mechanism. JF - Arthritis Research & Therapy AU - Janjanin, S AU - Djouad, F AU - Shanti, R M AU - Baksh, D AU - Gollapudi, K AU - Prgomet, D AU - Rackwitz, L AU - Joshi, A AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 1 VL - 10 IS - 4 SN - 1478-6354, 1478-6354 KW - Biotechnology and Bioengineering Abstracts KW - Mixed leukocyte reaction KW - Age KW - Cartilage KW - CD44 antigen KW - Bone marrow KW - Therapeutic applications KW - Major histocompatibility complex KW - Pain KW - CD14 antigen KW - Morbidity KW - Differentiation KW - Stem cells KW - Tonsil KW - Placenta KW - Lymphocytes T KW - Mesenchyme KW - Epitopes KW - CD105 antigen KW - Cell number KW - CD45 antigen KW - CD34 antigen KW - Umbilicus KW - Lymphoid tissue KW - Bone (trabecular) KW - CD90 antigen KW - CD29 antigen KW - Cell proliferation KW - Surface markers KW - Adherent cells KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19288742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=Human+palatine+tonsil%3A+a+new+potential+tissue+source+of+multipotent+mesenchymal+progenitor+cells&rft.au=Janjanin%2C+S%3BDjouad%2C+F%3BShanti%2C+R+M%3BBaksh%2C+D%3BGollapudi%2C+K%3BPrgomet%2C+D%3BRackwitz%2C+L%3BJoshi%2C+A%3BTuan%2C+R+S&rft.aulast=Janjanin&rft.aufirst=S&rft.date=2008-01-01&rft.volume=10&rft.issue=4&rft.spage=R83&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2459 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Tonsil; Major histocompatibility complex; Lymphocytes T; Mesenchyme; Bone (trabecular); CD105 antigen; Bone marrow; CD45 antigen; Mixed leukocyte reaction; Cell proliferation; CD34 antigen; CD90 antigen; Cell number; Epitopes; CD14 antigen; Therapeutic applications; Adherent cells; Placenta; Morbidity; Umbilicus; CD44 antigen; Age; CD29 antigen; Surface markers; Lymphoid tissue; Pain; Cartilage DO - http://dx.doi.org/10.1186/ar2459 ER - TY - JOUR T1 - Incidence and Completeness of Notification of Legionnaires' Disease in the Netherlands: Covariate Capture-Recapture Analysis Acknowledging Regional Differences AN - 1667004777; 8189604 AB - To estimate incidence and completeness of notification of Legionnaires' disease (LD) in The Netherlands in 2000 and 2001, we performed a capture- recapture analysis using three registers: Notifications, Laboratory results and Hospital admissions. After record-linkage, 373 of the 780 LD patients identified were notified. Ascertained under-notification was 52 super(.)2%. Because of expected and observed regional differences in the incidence rate of LD, alternatively to conventional log-linear capture-recapture models, a covariate (region) capture-recapture model, not previously used for estimating infectious disease incidence, was specified and estimated 886 LD patients (95% confidence interval 827-1022). Estimated under-notification was 57 super(.)9%. Notified, ascertained and estimated average annual incidence rates of LD were 1 super(.)15, 2 super(.)42 and 2 super(.)77/100 000 inhabitants respectively, with the highest incidence in the southern region of The Netherlands. Covariate capture-recapture analysis acknowledging regional differences of LD incidence appears to reduce bias in the estimated national incidence rate. JF - Epidemiology and Infection AU - Van Hest, NAH AU - Hoebe, CJPA AU - Boer, JWDen AU - Vermunt, J K AU - Ijzerman, EPF AU - Boersma, W G AU - Richardus, J H AD - Department of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands, vanhestr@ggd.rotterdam.nl Y1 - 2008 PY - 2008 DA - 2008 SP - 540 EP - 550 PB - Cambridge University Press, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org] VL - 136 IS - 4 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology KW - Infectious diseases KW - Models KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667004777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Prediction+of+rodent+carcinogenic+potential+of+naturally+occurring+chemicals+in+the+human+diet+using+high-throughput+QSAR+predictive+modeling&rft.au=Valerio%2C+L+G%3BArvidson%2C+K+B%3BChanderbhan%2C+R+F%3BContrera%2C+J+F&rft.aulast=Valerio&rft.aufirst=L&rft.date=2007-07-01&rft.volume=222&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Infectious diseases; Hospitals; Models DO - http://dx.doi.org/10.1017/S0950268807008977 ER - TY - JOUR T1 - Diagnosing and controlling moisture-sensitive roof in coal mines AN - 1560085620; 2014-066486 AB - Historically, coal miners have known that roof shales can deteriorate in contact with humid mine air, causing massive roof falls and injuries from falling rock. It is critical to recognize rocks prone to weathering and to adequately support these rocks in order to ensure the long-term stability of the openings. In a recent study, NIOSH has used a wet/dry cycling test to determine the moisture sensitivity of over 800 specimens of roof rock from 25 U.S. coal mines. Fireclays and some gray shales are the most moisture-sensitive. Rocks with disturbed bedding, in contrast to flat-bedded rocks, are also more sensitive to water. Black shales are relatively un-reactive to moisture and serve to protect more reactive gray shales above. Mines that have roof rocks with moisture-sensitivity indexes above 40% can experience slaking roof conditions, and many require high coverage surface controls. Three case studies are presented in which the moisture-sensitivity index is correlated to roof conditions underground, and can be used to indicate long term deterioration. Engineering measures are described to control moisture-sensitive roof. In one case, roof screen not only reduces injuries from rock fall but also is shown to reduce roof falls. JF - The Electronic Journal of Geotechnical Engineering AU - Molinda, Greg AU - Klemetti, Ted Y1 - 2008 PY - 2008 DA - 2008 SP - 20 PB - Mete Oner, Stillwater, OK VL - 13 IS - Bundle A KW - United States KW - mines KW - shale KW - roof control KW - moisture KW - coal mines KW - stability KW - weathering KW - rock mechanics KW - case studies KW - black shale KW - sedimentary rocks KW - mining geology KW - clastic rocks KW - fireclay KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560085620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Electronic+Journal+of+Geotechnical+Engineering&rft.atitle=Diagnosing+and+controlling+moisture-sensitive+roof+in+coal+mines&rft.au=Molinda%2C+Greg%3BKlemetti%2C+Ted&rft.aulast=Molinda&rft.aufirst=Greg&rft.date=2008-01-01&rft.volume=13&rft.issue=Bundle+A&rft.spage=&rft.isbn=&rft.btitle=&rft.title=The+Electronic+Journal+of+Geotechnical+Engineering&rft.issn=1089-3032&rft_id=info:doi/ L2 - http://www.ejge.com/Index_ejge.htm LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2017, American Geosciences Institute. N1 - Date revised - 2014-01-01 N1 - Number of references - 21 N1 - PubXState - OK N1 - Document feature - illus. incl. 2 tables, sketch maps N1 - Last updated - 2017-01-19 N1 - SubjectsTermNotLitGenreText - black shale; case studies; clastic rocks; coal mines; fireclay; mines; mining geology; moisture; rock mechanics; roof control; sedimentary rocks; shale; stability; United States; weathering ER - TY - JOUR T1 - Over-the-counter vaginal contraceptive and spermicide drug products containing nonoxynol 9; required labeling. Final rule. AN - 69082878; 18159651 AB - The Food and Drug Administration (FDA) is issuing a final rule establishing new warning statements and other labeling information for all over-the-counter (OTC) vaginal contraceptive drug products (also known as spermicides, hereinafter referred to as vaginal contraceptives or vaginal contraceptives/spermicides) containing nonoxynol 9 (N9). These warning statements will advise consumers that vaginal contraceptives/spermicides containing N9 do not protect against infection from the human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), or against getting other sexually transmitted diseases (STDs). The warnings and labeling information will also advise consumers that use of vaginal contraceptives and spermicides containing N9 can irritate the vagina and rectum and may increase the risk of getting the AIDS virus (HIV) from an infected partner. This final rule is part of FDA's ongoing review of OTC drug products. FDA is issuing this final rule after considering public comments on its proposed regulation, and all relevant data and information on N9 that have come to our attention. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2007/12/19/ PY - 2007 DA - 2007 Dec 19 SP - 71769 EP - 71785 VL - 72 IS - 243 SN - 0097-6326, 0097-6326 KW - Contraceptive Agents KW - 0 KW - Nonprescription Drugs KW - Spermatocidal Agents KW - Nonoxynol KW - 26027-38-3 KW - Health technology assessment KW - United States KW - Condoms KW - Nonprescription Drugs -- adverse effects KW - HIV Infections -- transmission KW - Nonprescription Drugs -- therapeutic use KW - Humans KW - HIV Infections -- prevention & control KW - Nonprescription Drugs -- administration & dosage KW - Sexually Transmitted Diseases -- prevention & control KW - Sexually Transmitted Diseases -- transmission KW - Male KW - Female KW - Contraceptive Agents -- therapeutic use KW - Spermatocidal Agents -- adverse effects KW - Nonoxynol -- administration & dosage KW - Contraceptive Agents -- administration & dosage KW - Nonoxynol -- therapeutic use KW - Spermatocidal Agents -- administration & dosage KW - Nonoxynol -- adverse effects KW - Drug Labeling -- legislation & jurisprudence KW - Spermatocidal Agents -- therapeutic use KW - Contraceptive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69082878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Over-the-counter+vaginal+contraceptive+and+spermicide+drug+products+containing+nonoxynol+9%3B+required+labeling.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2007-12-19&rft.volume=72&rft.issue=243&rft.spage=71769&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-11 N1 - Date created - 2007-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epigenetic changes in the rat livers induced by pyrazinamide treatment AN - 20841297; 7939496 AB - Drug-induced liver injury, including drug-induced hepatotoxicity during the treatment of tuberculosis infection, is a major health problem with increasingly significant challenges to modern hepatology. Therefore, the assessment and monitoring of the hepatotoxicity of antituberculosis drugs for prevention of liver injury are great concerns during disease treatment. The recently emerged data showing the ability of toxicants, including pharmaceutical agents, to alter cellular epigenetic status, open a unique opportunity for early detection of drug hepatotoxicity. Here we report that treatment of male Wistar rats with antituberculosis drug pyrazinamide at doses of 250, 500 or 1000 mg/kg/day body weight for 45 days leads to an early and sustained decrease in cytosine DNA methylation, progressive hypomethylation of long interspersed nucleotide elements (LINE-1), and aberrant promoter hypermethylation of placental form glutathione-S-transferase (GSTP) and p16 super(I) super(N) super(K) super(4) super(A) genes in livers of pyrazinamide-treated rats, while serum levels of bilirubin and activity of aminotransferases changed modestly. The early occurrence of these epigenetic alterations and their association with progression of liver injury specific pathological changes indicate that alterations in DNA methylation may be useful predictive markers for the assessment of drug hepatotoxicity. JF - Toxicology and Applied Pharmacology AU - Kovalenko, V M AU - Bagnyukova, T V AU - Sergienko, O V AU - Bondarenko, L B AU - Shayakhmetova, G M AU - Matvienko, A V AU - Pogribny, I P AD - Jefferson, AR, USA, igor.pogribny@fda.hhs.gov Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 293 EP - 299 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 225 IS - 3 SN - 0041-008X, 0041-008X KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Toxicology Abstracts KW - Toxicants KW - Injuries KW - Mycobacterium KW - Glutathione transferase KW - Infection KW - Drug screening KW - Promoters KW - Cytosine KW - p16 protein KW - Body weight KW - epigenetics KW - Placenta KW - DNA methylation KW - Long interspersed nucleotide elements KW - Tuberculosis KW - Bilirubin KW - Drugs KW - Data processing KW - INK4a protein KW - hepatotoxicity KW - Serum levels KW - Liver KW - Pharmaceuticals KW - pyrazinamide KW - J 02310:Genetics & Taxonomy KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20841297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Epigenetic+changes+in+the+rat+livers+induced+by+pyrazinamide+treatment&rft.au=Kovalenko%2C+V+M%3BBagnyukova%2C+T+V%3BSergienko%2C+O+V%3BBondarenko%2C+L+B%3BShayakhmetova%2C+G+M%3BMatvienko%2C+A+V%3BPogribny%2C+I+P&rft.aulast=Kovalenko&rft.aufirst=V&rft.date=2007-12-15&rft.volume=225&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Injuries; Toxicants; INK4a protein; Drug screening; Infection; Glutathione transferase; hepatotoxicity; Serum levels; Cytosine; Promoters; p16 protein; Body weight; epigenetics; Placenta; Liver; DNA methylation; Pharmaceuticals; Long interspersed nucleotide elements; Bilirubin; Tuberculosis; pyrazinamide; Drugs; Mycobacterium DO - http://dx.doi.org/10.1016/j.taap.2007.08.011 ER - TY - JOUR T1 - Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. AN - 69056043; 18074021 AB - DNA helicases are ubiquitous enzymes that unwind DNA in an ATP-dependent and directionally specific manner. Unwinding of double-stranded DNA is essential for the processes of DNA repair, recombination, transcription, and DNA replication. Five human DNA helicases sharing sequence similarity with the E. coli RecQ helicase have been identified. Three of the human RecQ helicases are implicated in hereditary diseases (Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome) which display clinical symptoms of premature aging and cancer. RECQ1 helicase is the most highly expressed of the human RecQ helicases; however, a genetic disease has yet not been linked to mutations in the RECQ1 gene, and the biological functions of human RECQ1 in cellular DNA metabolism are not known. In this study, we report that RECQ1 becomes phosphorylated upon DNA damage and forms irradiation-induced nuclear foci that associate with chromatin in human cells. Depletion of RECQ1 renders human cells sensitive to DNA damage induced by ionizing radiation or the topoisomerase inhibitor camptothecin, and results in spontaneous gamma-H2AX foci and elevated sister chromatid exchanges, indicating aberrant repair of DNA breaks. Consistent with a role in homologous recombinational repair, endogenous RECQ1 is associated with the strand exchange protein Rad51 and the two proteins directly interact with high affinity. Collectively, these results provide the first evidence for a role of human RECQ1 in the response to DNA damage and chromosomal stability maintenance and point to the vital importance of RECQ1 in genome homeostasis. JF - PloS one AU - Sharma, Sudha AU - Brosh, Robert M AD - Laboratory of Molecular Gerontology, Department of Health and Human Services, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America. Y1 - 2007/12/12/ PY - 2007 DA - 2007 Dec 12 SP - 1 VL - 2 IS - 12 KW - Mutagens KW - 0 KW - RNA, Small Interfering KW - RecQ Helicases KW - EC 3.6.4.12 KW - Index Medicus KW - Base Sequence KW - HeLa Cells KW - Humans KW - Sister Chromatid Exchange KW - DNA Damage KW - RecQ Helicases -- metabolism KW - Oxidative Stress KW - RecQ Helicases -- genetics KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69056043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Human+RECQ1+is+a+DNA+damage+responsive+protein+required+for+genotoxic+stress+resistance+and+suppression+of+sister+chromatid+exchanges.&rft.au=Sharma%2C+Sudha%3BBrosh%2C+Robert+M&rft.aulast=Sharma&rft.aufirst=Sudha&rft.date=2007-12-12&rft.volume=2&rft.issue=12&rft.spage=e1297&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-08 N1 - Date created - 2007-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Aug 4;275(31):23500-8 [10825162] Nucleic Acids Res. 2004;32(7):2158-70 [15096578] Mol Cell Biol. 2001 Jan;21(1):281-8 [11113202] J Cell Biol. 2001 Apr 16;153(2):367-80 [11309417] J Biol Chem. 2001 Jun 1;276(22):19375-81 [11278509] Mutat Res. 2002 Nov 30;509(1-2):49-78 [12427531] Mol Biol Cell. 2002 Nov;13(11):4100-9 [12429849] Oncogene. 2002 Dec 16;21(58):9008-21 [12483516] J Biol Chem. 2003 Jan 17;278(3):1424-32 [12419808] Curr Genet. 2003 Jan;42(4):220-7 [12589473] Science. 1999 Dec 17;286(5448):2342-4 [10600745] Carcinogenesis. 2000 Mar;21(3):485-95 [10688869] Cancer Res. 2000 Mar 1;60(5):1162-7 [10728666] Hum Mol Genet. 2000 Jul 22;9(12):1805-11 [10915769] EMBO J. 2003 Mar 3;22(5):1210-22 [12606585] Nat Rev Cancer. 2003 Mar;3(3):169-78 [12612652] Mol Cell Biol. 2003 May;23(10):3527-35 [12724411] Mol Cell Biol. 2003 May;23(10):3692-705 [12724426] Nature. 2003 May 15;423(6937):305-9 [12748644] Nature. 2003 May 15;423(6937):309-12 [12748645] Genes Dev. 2003 Aug 15;17(16):2021-35 [12893777] Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543] Nature. 2003 Dec 18;426(6968):870-4 [14685245] Mol Cell Biol. 2004 Feb;24(3):1279-91 [14729972] Curr Genet. 2004 Feb;45(1):37-44 [14595518] Cancer Res. 2004 Mar 1;64(5):1834-42 [14996747] J Cell Biol. 2004 Sep 13;166(6):801-13 [15364958] Nature. 1974 Sep 13;251(5471):156-8 [4138930] Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 [6828386] Cancer Genet Cytogenet. 1993 Oct 15;70(2):85-93 [8242603] J Biol Chem. 1994 Nov 25;269(47):29838-45 [7961977] Nucleic Acids Res. 1994 Nov 11;22(22):4566-73 [7527136] Genomics. 1995 Apr 10;26(3):595-8 [7607686] Cell. 1997 Feb 7;88(3):323-31 [9039259] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6887-92 [9618508] Exp Cell Res. 1998 Aug 1;242(2):487-94 [9683536] Nature. 2005 Jan 6;433(7021):77-83 [15635413] Blood. 2005 Feb 1;105(3):1003-9 [15454491] Nat Rev Mol Cell Biol. 2005 Jan;6(1):44-55 [15688066] Genetics. 2005 Feb;169(2):563-74 [15489516] Mol Cell Biol. 2005 May;25(9):3431-42 [15831450] EMBO J. 2005 Apr 6;24(7):1465-76 [15775963] Cancer Cell. 2005 Jun;7(6):505-12 [15950900] EMBO J. 2005 Jul 20;24(14):2679-87 [15990871] J Biol Chem. 2005 Jul 29;280(30):28085-94 [15886194] J Biol Chem. 2005 Jul 29;280(30):28072-84 [15899892] J Cell Sci. 2005 Sep 15;118(Pt 18):4261-9 [16141230] Mol Cell Biol. 2005 Oct;25(20):8925-37 [16199871] Nucleic Acids Res. 2005;33(19):6251-7 [16260474] Genetics. 2006 Jan;172(1):113-25 [16219790] Cancer Res. 2006 Mar 15;66(6):3323-30 [16540687] J Clin Oncol. 2006 Apr 10;24(11):1720-8 [16520463] Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5875-80 [16595622] Science. 2006 Jul 21;313(5785):363-7 [16778019] Biochem J. 2006 Sep 15;398(3):319-37 [16925525] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] Mol Cell Biol. 2007 Mar;27(5):1784-94 [17158923] PLoS Biol. 2007 Feb;5(2):e20 [17227144] J Cell Sci. 2007 Mar 1;120(Pt 5):713-21 [17314245] Bioessays. 2007 Apr;29(4):382-5 [17373697] Nat Struct Mol Biol. 2007 Jul;14(7):677-9 [17603497] Oncogene. 2000 Sep 28;19(41):4764-72 [11032027] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles. AN - 68539997; 17981407 AB - In order to evaluate the pulmonary effects and inflammatory mechanisms of ultrafine amorphous silica particles (UFASs), the UFASs suspension was prepared in PBS and intratracheally administered to A/J mice at doses of 0, 2, 10 and 50mg/kg (n=5 per group). Animals were sacrificed at 24h, and 1, 4 or 14 weeks following exposures. At each time point, a bronchoalveolar lavage fluid analysis, histopathological examination, quantitative real-time PCR and immunohistochemistry of the lung tissues were assessed. The intratracheal instillation of UFASs significantly increased the lung weights and total BAL cells following exposures. The histopathological examination revealed that UFASs-induced severe inflammation, with neutrophils, at an early stage and chronic granulomatous inflammation at the later stage. The mRNA and protein levels of IL-1beta, IL-6, IL-8, TNF-alpha, MCP-1 and MIP-2 in lung tissues were significantly increased during the early stages, but there were no changes after weeks 1 (TNF-alpha) or 4 (IL-1beta, IL-6, IL-8, MCP-1 and MIP-2). Instillation of UFASs-induced transient, but very severe lung inflammation. Therefore, the cytokines (IL-1beta, IL-6, IL-8 and TNF-alpha) and chemokines (MCP-1 and MIP-2) play important roles in the inflammation induced by the intratracheal instillation of UFASs. JF - Toxicology letters AU - Cho, Wan-Seob AU - Choi, Mina AU - Han, Beom Seok AU - Cho, Minjung AU - Oh, Jaeho AU - Park, Kidae AU - Kim, Sung Jun AU - Kim, Seung Hee AU - Jeong, Jayoung AD - Division of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea. Y1 - 2007/12/10/ PY - 2007 DA - 2007 Dec 10 SP - 24 EP - 33 VL - 175 IS - 1-3 SN - 0378-4274, 0378-4274 KW - Cytokines KW - 0 KW - Inflammation Mediators KW - Proteins KW - RNA, Messenger KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Animals KW - Macrophages -- immunology KW - Particle Size KW - Mice KW - RNA, Messenger -- biosynthesis KW - Leukocyte Count KW - Inflammation Mediators -- metabolism KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Proteins -- analysis KW - Up-Regulation KW - Administration, Inhalation KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Organ Size -- drug effects KW - Cytokines -- genetics KW - Cytokines -- biosynthesis KW - Lung -- drug effects KW - Silicon Dioxide -- toxicity KW - Lung -- pathology KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68539997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Inflammatory+mediators+induced+by+intratracheal+instillation+of+ultrafine+amorphous+silica+particles.&rft.au=Cho%2C+Wan-Seob%3BChoi%2C+Mina%3BHan%2C+Beom+Seok%3BCho%2C+Minjung%3BOh%2C+Jaeho%3BPark%2C+Kidae%3BKim%2C+Sung+Jun%3BKim%2C+Seung+Hee%3BJeong%2C+Jayoung&rft.aulast=Cho&rft.aufirst=Wan-Seob&rft.date=2007-12-10&rft.volume=175&rft.issue=1-3&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2007-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - S-ethyl-N,N-dipropylthiocarbamate (EPTC) Exposure and Cancer Incidence among Male Pesticide Applicators in the Agricultural Health Study, a Prospective Cohort. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40809096; 4802173 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Van Bemmel, D M AU - Visvanathan, K AU - Freeman, L. E. Beane AU - Coble, J B AU - Hoppin, J A AU - Alavanja, M. C.R. Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Cancer KW - Pesticides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40809096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=S-ethyl-N%2CN-dipropylthiocarbamate+%28EPTC%29+Exposure+and+Cancer+Incidence+among+Male+Pesticide+Applicators+in+the+Agricultural+Health+Study%2C+a+Prospective+Cohort.&rft.au=Van+Bemmel%2C+D+M%3BVisvanathan%2C+K%3BFreeman%2C+L.+E.+Beane%3BCoble%2C+J+B%3BHoppin%2C+J+A%3BAlavanja%2C+M.+C.R.&rft.aulast=Van+Bemmel&rft.aufirst=D&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Evidence for the reaffirmation of the U.S. Preventive Services Task Force recommendation on screening for high blood pressure. AN - 69031116; 18056663 AB - High blood pressure is common, and screening is a well-established evidence-based standard of current medical practice. To perform a literature search for new, substantial evidence on screening for high blood pressure that would inform the reaffirmation of the U.S. Preventive Services Task Force recommendation on screening for high blood pressure. The PubMed and Cochrane databases were searched. The searches were limited to English-language articles on studies of adult humans (age >18 years) that were published between 1 October 2001 and 31 March 2006 in core clinical journals. For the literature on benefits, meta-analyses; systematic reviews; and randomized, controlled trials were included. For harms, meta-analyses; systematic reviews; randomized, controlled trials; cohort studies; case-control studies; and case series of large, multisite databases were included. Two reviewers independently reviewed titles, abstracts, and full articles for inclusion. No new evidence was found on benefits or harms of screening. Two reviewers extracted data from studies on the harms of early treatment, including adverse effects of drug therapy and adverse quality-of-life outcomes. No new evidence was found for the benefits of screening for high blood pressure. New evidence on the harms of treatment of early hypertension shows that pharmacologic therapy is associated with common side effects; serious adverse events are uncommon. The nonsystematic search may have missed some smaller studies on the benefits and harms of screening and treatment for high blood pressure. No new evidence was found on the benefits of screening. Pharmacotherapy for early hypertension is associated with common side effects. JF - Annals of internal medicine AU - Wolff, Tracy AU - Miller, Therese AD - .S. Preventive Services Task Force Program, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. Y1 - 2007/12/04/ PY - 2007 DA - 2007 Dec 04 SP - 787 EP - 791 VL - 147 IS - 11 KW - Antihypertensive Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Cardiovascular Diseases -- etiology KW - Risk Factors KW - Humans KW - Antihypertensive Agents -- adverse effects KW - Adult KW - Time Factors KW - Male KW - Female KW - Cardiovascular Diseases -- prevention & control KW - Hypertension -- complications KW - Hypertension -- diagnosis KW - Mass Screening -- adverse effects KW - Hypertension -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69031116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Evidence+for+the+reaffirmation+of+the+U.S.+Preventive+Services+Task+Force+recommendation+on+screening+for+high+blood+pressure.&rft.au=Wolff%2C+Tracy%3BMiller%2C+Therese&rft.aulast=Wolff&rft.aufirst=Tracy&rft.date=2007-12-04&rft.volume=147&rft.issue=11&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-10 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Summary For Patients In: Ann Intern Med. 2007 Dec 4;147(11):I43 [18056657] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The Impact of Underage Drinking and the Risk of HIV Among African Americans T2 - 2007 National HIV Prevention Conference AN - 39716091; 4737329 JF - 2007 National HIV Prevention Conference AU - Richards, C AU - Cooke, V C AU - Schaffer, T M Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Africa KW - Human immunodeficiency virus KW - Ethnic groups KW - Drinking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39716091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=The+Impact+of+Underage+Drinking+and+the+Risk+of+HIV+Among+African+Americans&rft.au=Richards%2C+C%3BCooke%2C+V+C%3BSchaffer%2C+T+M&rft.aulast=Richards&rft.aufirst=C&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adapting the Popular Opinion Leader Intervention for Young Black Men Who have Sex with Men: Focusing on Peer Norms, Culture, and Social Stigma T2 - 2007 National HIV Prevention Conference AN - 39662983; 4737164 JF - 2007 National HIV Prevention Conference AU - Bost, D L AU - Jones, K T AU - Foust, E M AU - Gray, P A AU - Whiteside, Y O Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Opinion leaders KW - Homosexuality KW - Intervention KW - Stigma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39662983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Adapting+the+Popular+Opinion+Leader+Intervention+for+Young+Black+Men+Who+have+Sex+with+Men%3A+Focusing+on+Peer+Norms%2C+Culture%2C+and+Social+Stigma&rft.au=Bost%2C+D+L%3BJones%2C+K+T%3BFoust%2C+E+M%3BGray%2C+P+A%3BWhiteside%2C+Y+O&rft.aulast=Bost&rft.aufirst=D&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Training and Implementation for Protocol-Based Counseling (PBC) in Houston: An Evidence-Based CTR Intervention T2 - 2007 National HIV Prevention Conference AN - 39653523; 4737185 JF - 2007 National HIV Prevention Conference AU - Agee, G B AU - Wiley, C AU - Hall, H Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - USA, Texas, Houston KW - Training KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39653523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Training+and+Implementation+for+Protocol-Based+Counseling+%28PBC%29+in+Houston%3A+An+Evidence-Based+CTR+Intervention&rft.au=Agee%2C+G+B%3BWiley%2C+C%3BHall%2C+H&rft.aulast=Agee&rft.aufirst=G&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Creating HIV/STD Prevention Standards to Improve Quality Management Activities: A Houston Perspective T2 - 2007 National HIV Prevention Conference AN - 39634796; 4737113 JF - 2007 National HIV Prevention Conference AU - Mitts, B J AU - Joseph-White, D AU - Kweekeh, F AU - Washington-Philip, E AU - Simpson, B AU - Prescott, L Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - USA, Texas, Houston KW - Human immunodeficiency virus KW - Prevention KW - Sexually-transmitted diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Creating+HIV%2FSTD+Prevention+Standards+to+Improve+Quality+Management+Activities%3A+A+Houston+Perspective&rft.au=Mitts%2C+B+J%3BJoseph-White%2C+D%3BKweekeh%2C+F%3BWashington-Philip%2C+E%3BSimpson%2C+B%3BPrescott%2C+L&rft.aulast=Mitts&rft.aufirst=B&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prenatal HIV Screening: Ongoing Challenges and Lessons Learned T2 - 2007 National HIV Prevention Conference AN - 39634431; 4737045 JF - 2007 National HIV Prevention Conference AU - Reilley, B AU - Giberson, S AU - Cheek, J Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Prenatal+HIV+Screening%3A+Ongoing+Challenges+and+Lessons+Learned&rft.au=Reilley%2C+B%3BGiberson%2C+S%3BCheek%2C+J&rft.aulast=Reilley&rft.aufirst=B&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV/STD Planning and Implementation Through Community Groups T2 - 2007 National HIV Prevention Conference AN - 39628256; 4737121 JF - 2007 National HIV Prevention Conference AU - Hall, H H AU - Agee, G AU - Wiley, C AU - Cavazos, J Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Sexually-transmitted diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=HIV%2FSTD+Planning+and+Implementation+Through+Community+Groups&rft.au=Hall%2C+H+H%3BAgee%2C+G%3BWiley%2C+C%3BCavazos%2C+J&rft.aulast=Hall&rft.aufirst=H&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of Surveillance Data to Evaluate Concurrent HIV and AIDS Diagnoses in Houston/Harris County, TX T2 - 2007 National HIV Prevention Conference AN - 39622029; 4737493 JF - 2007 National HIV Prevention Conference AU - Chan, S AU - Yang, B AU - Mohammad, N AU - Harms, J AU - Wolverton, M AU - Meyer, J AU - Arafat, R Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - USA, Texas, Houston KW - Human immunodeficiency virus KW - Acquired immune deficiency syndrome KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=The+Use+of+Surveillance+Data+to+Evaluate+Concurrent+HIV+and+AIDS+Diagnoses+in+Houston%2FHarris+County%2C+TX&rft.au=Chan%2C+S%3BYang%2C+B%3BMohammad%2C+N%3BHarms%2C+J%3BWolverton%2C+M%3BMeyer%2C+J%3BArafat%2C+R&rft.aulast=Chan&rft.aufirst=S&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Breaking the Cycle/Mending the Hoop: Adverse Childhood Experiences Among Incarcerated American Indian and Alaska Native Women in New Mexico T2 - 2007 National HIV Prevention Conference AN - 39609860; 4737394 JF - 2007 National HIV Prevention Conference AU - De Ravello, L AU - Abeita, J AU - Brown, P Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - USA, New Mexico KW - USA, Alaska KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39609860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Breaking+the+Cycle%2FMending+the+Hoop%3A+Adverse+Childhood+Experiences+Among+Incarcerated+American+Indian+and+Alaska+Native+Women+in+New+Mexico&rft.au=De+Ravello%2C+L%3BAbeita%2C+J%3BBrown%2C+P&rft.aulast=De+Ravello&rft.aufirst=L&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Local Capacity Building and Training Unit: Houstons Perspective T2 - 2007 National HIV Prevention Conference AN - 39606091; 4737623 JF - 2007 National HIV Prevention Conference AU - Wiley, C P AU - Agee, G AU - Hall, H H Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - USA, Texas, Houston KW - Training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39606091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Development+of+a+Local+Capacity+Building+and+Training+Unit%3A+Houstons+Perspective&rft.au=Wiley%2C+C+P%3BAgee%2C+G%3BHall%2C+H+H&rft.aulast=Wiley&rft.aufirst=C&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Signs of the Time "Houston's Approach to Quality Management Through Realignment of Job Functions" T2 - 2007 National HIV Prevention Conference AN - 39596145; 4737449 DE: JF - 2007 National HIV Prevention Conference AU - Simpson, B AU - Washington-Philip, E AU - Kweekeh, F AU - Joseph-White, D AU - Prescott, L Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39596145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Signs+of+the+Time+%22Houston%27s+Approach+to+Quality+Management+Through+Realignment+of+Job+Functions%22&rft.au=Simpson%2C+B%3BWashington-Philip%2C+E%3BKweekeh%2C+F%3BJoseph-White%2C+D%3BPrescott%2C+L&rft.aulast=Simpson&rft.aufirst=B&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Indian Health Service's HIV Management System Clinical Software T2 - 2007 National HIV Prevention Conference AN - 39571826; 4737416 JF - 2007 National HIV Prevention Conference AU - Cullen, T AU - Gebremariam, C P Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Computer programs KW - Software KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39571826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=The+Indian+Health+Service%27s+HIV+Management+System+Clinical+Software&rft.au=Cullen%2C+T%3BGebremariam%2C+C+P&rft.aulast=Cullen&rft.aufirst=T&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Surveillance Dos and Donts: False Positive HIV Western Blots in Pregnant Women T2 - 2007 National HIV Prevention Conference AN - 39525546; 4737618 JF - 2007 National HIV Prevention Conference AU - Chan, S AU - Harms, J AU - Yang, B AU - Mohammad, N AU - Meyer, J AU - Wolverton, M AU - Arafat, R Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Western blotting KW - Pregnancy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39525546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Surveillance+Dos+and+Donts%3A+False+Positive+HIV+Western+Blots+in+Pregnant+Women&rft.au=Chan%2C+S%3BHarms%2C+J%3BYang%2C+B%3BMohammad%2C+N%3BMeyer%2C+J%3BWolverton%2C+M%3BArafat%2C+R&rft.aulast=Chan&rft.aufirst=S&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Backpropagation ANN-Based Prediction of Exertional Heat Illness AN - 757015561; 18041290 AB - Exertional heat illness is primarily a multi-system disorder results from the combined effect of exertional and thermoregulation stress. The severity of exertional heat illness can be classified as mild, intermediate and severe from non-specific symptoms like thirst, myalgia, poor concentration, hysteria, vomiting, weakness, cramps, impaired judgement, headache, diarrhea, fatigue, hyperventilation, anxiety, and nausea to more severe symptoms like exertional dehydration, heat cramps, heat exhaustion, heat injury, heatstroke, rhabdomyolysis, and acute renal failure. At its early stage, it is quite difficult to find out the severity of disease with manual screening because of overlapping of symptoms. Therefore, one need to classify automatically the disease based on symptoms. The 7:10:1 backpropagation artificial neural network model has been used to predict the clinical outcome from the symptoms that are routinely available to clinicians. The model has found to be effective in differentiating the different stages of exertional heat-illness with an overall performance of 100%.[PUBLICATION ABSTRACT] JF - Journal of Medical Systems AU - Aggarwal, Yogender AU - Karan, Bhuwan Mohan AU - Das, Barda Nand AU - Aggarwal, Tarana AU - Sinha, Rakesh Kumar Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 547 EP - 50 CY - New York PB - Springer Science & Business Media VL - 31 IS - 6 SN - 0148-5598 KW - Medical Sciences--Computer Applications KW - Neural networks KW - Heatstroke KW - Back propagation KW - Illnesses KW - Body Temperature Regulation KW - Humans KW - Heat Exhaustion -- diagnosis KW - Outcome Assessment (Health Care) KW - India KW - Heat Exhaustion -- physiopathology KW - Neural Networks (Computer) KW - Physical Exertion -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757015561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomputing&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Systems&rft.atitle=Backpropagation+ANN-Based+Prediction+of+Exertional+Heat+Illness&rft.au=Aggarwal%2C+Yogender%3BKaran%2C+Bhuwan+Mohan%3BDas%2C+Barda+Nand%3BAggarwal%2C+Tarana%3BSinha%2C+Rakesh+Kumar&rft.aulast=Aggarwal&rft.aufirst=Yogender&rft.date=2007-12-01&rft.volume=31&rft.issue=6&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Systems&rft.issn=01485598&rft_id=info:doi/10.1007%2Fs10916-007-9097-5 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2007 N1 - Last updated - 2014-07-26 DO - http://dx.doi.org/10.1007/s10916-007-9097-5 ER - TY - JOUR T1 - Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas. AN - 70089026; 18247017 AB - Erlotinib (Tarceva) is a human epidermal growth factor receptor type 1/epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor initially approved by the US Food and Drug Administration for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer after failure of at least one prior chemotherapy regimen. In this report, we present the pivotal study that led to the approval of erlotinib in combination with gemcitabine (Gemzar) in patients with locally advanced/metastatic chemonaive pancreatic cancer patients. The combination demonstrated a statistically significant increase in overall survival accompanied by an increase in toxicity. Physicians and patients now have a new option for the treatment of locally advanced/metastatic adenocarcinoma of the pancreas. JF - Oncology (Williston Park, N.Y.) AU - Senderowicz, Adrian M AU - Johnson, John R AU - Sridhara, Rajeshwari AU - Zimmerman, Paul AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. adrian.senderowicz@fda.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1696 EP - 706; discussion 1706-9, 1712, 1715 VL - 21 IS - 14 SN - 0890-9091, 0890-9091 KW - Antimetabolites, Antineoplastic KW - 0 KW - Protein Kinase Inhibitors KW - Quinazolines KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Erlotinib Hydrochloride KW - DA87705X9K KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Antimetabolites, Antineoplastic -- administration & dosage KW - Double-Blind Method KW - Antimetabolites, Antineoplastic -- adverse effects KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Protein Kinase Inhibitors -- administration & dosage KW - Aged KW - Quinazolines -- administration & dosage KW - Deoxycytidine -- adverse effects KW - Protein Kinase Inhibitors -- adverse effects KW - Aged, 80 and over KW - Adult KW - Cohort Studies KW - Deoxycytidine -- administration & dosage KW - Middle Aged KW - Quinazolines -- adverse effects KW - Male KW - Female KW - Survival Analysis KW - Pancreatic Neoplasms -- pathology KW - Adenocarcinoma -- secondary KW - Pancreatic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Adenocarcinoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70089026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+%28Williston+Park%2C+N.Y.%29&rft.atitle=Erlotinib%2Fgemcitabine+for+first-line+treatment+of+locally+advanced+or+metastatic+adenocarcinoma+of+the+pancreas.&rft.au=Senderowicz%2C+Adrian+M%3BJohnson%2C+John+R%3BSridhara%2C+Rajeshwari%3BZimmerman%2C+Paul%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Senderowicz&rft.aufirst=Adrian&rft.date=2007-12-01&rft.volume=21&rft.issue=14&rft.spage=1696&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Williston+Park%2C+N.Y.%29&rft.issn=08909091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-06 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characteristics of dusts encountered during the production of cemented tungsten carbides. AN - 70076805; 18212475 AB - Inhalation of cobalt (Co) and tungsten carbide (WC) particles, but not Co or WC alone, may cause hard metal disease, risk of which does not appear to be uniform across cemented tungsten carbide (CTC) production processes. Inhalation of Co alone or in the presence of WC may cause asthma. Hypothesizing that aerosol size, chemical content, heterogeneity, and constituent compaction may be important exposure factors, we characterized aerosols from representative CTC manufacturing processes. Six work areas were sampled to characterize aerosol size distributions (dust, Co) and 12 work areas were sampled to characterize physicochemical properties (using scanning electron microscopy with energy dispersive x-ray spectrometry [SEM-EDX]). Bulk feedstock and process-generated powders were characterized with SEM-EDX and x-ray diffraction. The dust mass median diameter was respirable and the cobalt respirable mass fraction was highest (37%) in grinding. Morphology of particles changed with processing: individual, agglomerate, or aggregates (pre-sintered materials), then mostly compacted particles (subsequent to sintering). Elemental composition of particles became increasingly heterogeneous: mostly discrete Co or W particles (prior to spray drying), then heterogeneous W/Co particles (subsequent work areas). Variability in aerosol respirability and chemical heterogeneity could translate into differences in toxicity and support detailed characterization of physicochemical properties during exposure assessments. JF - Industrial health AU - Stefaniak, Aleksandr B AU - Day, Gregory A AU - Harvey, Christopher J AU - Leonard, Stephen S AU - Schwegler-Berry, Diane E AU - Chipera, Steve J AU - Sahakian, Nancy M AU - Chisholm, William P AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 793 EP - 803 VL - 45 IS - 6 SN - 0019-8366, 0019-8366 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Alloys KW - Dust KW - hard metal KW - Cobalt KW - 3G0H8C9362 KW - Tungsten KW - V9306CXO6G KW - Index Medicus KW - Aerosols -- analysis KW - Particle Size KW - Asthma -- chemically induced KW - Occupational Diseases -- chemically induced KW - Environmental Monitoring -- methods KW - Alloys -- analysis KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Tungsten -- analysis KW - Air Pollutants, Occupational -- adverse effects KW - Occupational Exposure -- adverse effects KW - Cobalt -- analysis KW - Cobalt -- adverse effects KW - Alloys -- adverse effects KW - Tungsten -- adverse effects KW - Manufactured Materials KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70076805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+health&rft.atitle=Characteristics+of+dusts+encountered+during+the+production+of+cemented+tungsten+carbides.&rft.au=Stefaniak%2C+Aleksandr+B%3BDay%2C+Gregory+A%3BHarvey%2C+Christopher+J%3BLeonard%2C+Stephen+S%3BSchwegler-Berry%2C+Diane+E%3BChipera%2C+Steve+J%3BSahakian%2C+Nancy+M%3BChisholm%2C+William+P&rft.aulast=Stefaniak&rft.aufirst=Aleksandr&rft.date=2007-12-01&rft.volume=45&rft.issue=6&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Industrial+health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-22 N1 - Date created - 2008-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A prospective study of red and processed meat intake in relation to cancer risk. AN - 69086300; 18076279 AB - Red meat and processed meat have been associated with carcinogenesis at several anatomic sites, but no prospective study has examined meat intake in relation to a range of malignancies. We investigated whether red or processed meat intake increases cancer risk at a variety of sites. The National Institutes of Health (NIH)-AARP (formerly the American Association for Retired Persons) Diet and Health Study is a cohort of approximately 500,000 people aged 50-71 y at baseline (1995-1996). Meat intake was estimated from a food frequency questionnaire administered at baseline. Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals within quintiles of red and processed meat intake. During up to 8.2 y of follow-up, 53,396 incident cancers were ascertained. Statistically significant elevated risks (ranging from 20% to 60%) were evident for esophageal, colorectal, liver, and lung cancer, comparing individuals in the highest with those in the lowest quintile of red meat intake. Furthermore, individuals in the highest quintile of processed meat intake had a 20% elevated risk for colorectal and a 16% elevated risk for lung cancer. Both red and processed meat intakes were positively associated with cancers of the colorectum and lung; furthermore, red meat intake was associated with an elevated risk for cancers of the esophagus and liver. JF - PLoS medicine AU - Cross, Amanda J AU - Leitzmann, Michael F AU - Gail, Mitchell H AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Sinha, Rashmi AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America. crossa@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1 VL - 4 IS - 12 KW - Index Medicus KW - Sex Factors KW - Nutrition Assessment KW - Humans KW - Aged KW - Risk Assessment KW - Lung Neoplasms -- etiology KW - Prospective Studies KW - Risk Factors KW - Surveys and Questionnaires KW - Colorectal Neoplasms -- etiology KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Esophageal Neoplasms -- etiology KW - Liver Neoplasms -- etiology KW - United States -- epidemiology KW - Time Factors KW - Female KW - Male KW - Proportional Hazards Models KW - Meat Products -- adverse effects KW - Meat -- adverse effects KW - Neoplasms -- epidemiology KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+medicine&rft.atitle=A+prospective+study+of+red+and+processed+meat+intake+in+relation+to+cancer+risk.&rft.au=Cross%2C+Amanda+J%3BLeitzmann%2C+Michael+F%3BGail%2C+Mitchell+H%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2007-12-01&rft.volume=4&rft.issue=12&rft.spage=e325&rft.isbn=&rft.btitle=&rft.title=PLoS+medicine&rft.issn=1549-1676&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-12-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nutr Cancer. 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[8268766] J Natl Cancer Inst. 1995 May 3;87(9):652-61 [7752270] Biochem Biophys Res Commun. 1995 May 16;210(2):350-5 [7755610] J Urol. 1996 Mar;155(3):969-74 [8583620] Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):895-9 [8634663] JAMA. 1996 May 1;275(17):1315-21 [8614116] Lung Cancer. 1996 Jun;14(2-3):195-205 [8794403] Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):161-6 [8833615] Princess Takamatsu Symp. 1995;23:232-9 [8844814] Int J Cancer. 1997 Mar 28;71(1):14-9 [9096659] Nutr Cancer. 1997;27(3):256-60 [9101555] Med Sci Sports Exerc. 1997 Jun;29(6 Suppl):S1-205 [9243481] Cancer Res. 1997 Nov 15;57(22):5077-85 [9371506] Int J Cancer. 1997 Nov 27;73(5):634-8 [9398038] Carcinogenesis. 1998 Jan;19(1):117-24 [9472702] Int J Cancer. 1998 May 29;76(5):659-64 [9610722] Hepatology. 1998 Jun;27(6):1563-6 [9620327] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Leuk Res. 1998 May;22(5):445-52 [9652731] J Med Microbiol. 1998 May;47(5):407-16 [9879941] Eur J Cancer Prev. 1998 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factor-kappaB, an unappreciated tumor suppressor. AN - 69033844; 18056430 AB - The notion that nuclear factor-kappaB (NF-kappaB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-kappaB in carcinogenesis and tumorigenesis. Although the tumor suppressor-like effect of NF-kappaB remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-kappaB activation as a broad strategy in treating cancers. JF - Cancer research AU - Chen, Fei AU - Castranova, Vince AD - The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. fchen@cdc.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 11093 EP - 11098 VL - 67 IS - 23 KW - NF-kappa B KW - 0 KW - Index Medicus KW - Humans KW - Neoplasms -- drug therapy KW - Genes, Tumor Suppressor -- physiology KW - NF-kappa B -- physiology KW - NF-kappa B -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69033844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Nuclear+factor-kappaB%2C+an+unappreciated+tumor+suppressor.&rft.au=Chen%2C+Fei%3BCastranova%2C+Vince&rft.aulast=Chen&rft.aufirst=Fei&rft.date=2007-12-01&rft.volume=67&rft.issue=23&rft.spage=11093&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-22 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells. AN - 69012242; 18049996 AB - With the development of nanotechnology, there is a tremendous growth of the application of nanomaterials, which increases the risk of human exposure to these nanomaterials through inhalation, ingestion, and dermal penetration. Among different types of nanoparticles, single-walled carbon nanotubes (SWCNT) with extremely small size (1 nm in diameter) exhibit extraordinary properties and offer possibilities to create materials with astounding features. Since the release of nanoparticles in an enclosed environment is of great concern, a study of possible genotoxic effects is important. Our previous data showed that pharyngeal aspiration of SWCNT elicited pulmonary effects in C57BL/6 mice that was promoted by a robust, acute inflammatory reaction with early onset resulting in progressive interstitial fibrogenic response and the formation of granulomas. In the present study, the genotoxic potential of SWCNT was evaluated in vitro. The genotoxic effects of nanoparticles were examined using three different test systems: the comet assay and micronucleus (MN) test in a lung fibroblast (V79) cell line, and the Salmonella gene mutation assay in strains YG1024/YG1029. Cytotoxicity tests showed loss of viability in a concentration- and time-dependent manner after exposure of cells to SWCNT. Results from the comet assay demonstrated the induction of DNA damage after only 3 h of incubation with 96 microg/cm2 of SWCNT. The MN test indicated some but not significant micronucleus induction by SWCNT in the V79 cell line at the highest concentrations tested. With two different strains of Salmonella typhimurium, no mutations were found following SWCNT exposure. JF - Journal of toxicology and environmental health. Part A AU - Kisin, Elena R AU - Murray, Ashley R AU - Keane, Michael J AU - Shi, Xiao-Chun AU - Schwegler-Berry, Diane AU - Gorelik, Olga AU - Arepalli, Sivaram AU - Castranova, Vincent AU - Wallace, William E AU - Kagan, Valerian E AU - Shvedova, Anna A AD - Pathology/Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2071 EP - 2079 VL - 70 IS - 24 SN - 1528-7394, 1528-7394 KW - Nanotubes, Carbon KW - 0 KW - Index Medicus KW - Animals KW - Mutagenicity Tests KW - Cricetulus KW - Cell Survival -- drug effects KW - DNA Damage KW - Lung -- cytology KW - Chromosome Aberrations KW - Salmonella typhimurium -- drug effects KW - Salmonella typhimurium -- genetics KW - Cell Line KW - Cricetinae KW - Fibroblasts -- drug effects KW - Fibroblasts -- cytology KW - Nanotubes, Carbon -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69012242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Single-walled+carbon+nanotubes%3A+geno-+and+cytotoxic+effects+in+lung+fibroblast+V79+cells.&rft.au=Kisin%2C+Elena+R%3BMurray%2C+Ashley+R%3BKeane%2C+Michael+J%3BShi%2C+Xiao-Chun%3BSchwegler-Berry%2C+Diane%3BGorelik%2C+Olga%3BArepalli%2C+Sivaram%3BCastranova%2C+Vincent%3BWallace%2C+William+E%3BKagan%2C+Valerian+E%3BShvedova%2C+Anna+A&rft.aulast=Kisin&rft.aufirst=Elena&rft.date=2007-12-01&rft.volume=70&rft.issue=24&rft.spage=2071&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug interaction studies of therapeutic proteins or monoclonal antibodies. AN - 69003880; 17962422 AB - Drug interactions can alter the pharmacokinetics and/or pharmacodynamics of a drug. In pharmacokinetic drug interactions, the concentrations of 1 or more drugs are altered by another. This change in concentration in a given drug may be due to changes in absorption, distribution, metabolism, or elimination. The pharmacodynamic interaction can lead to additive, synergistic, or antagonistic effects of a drug. Drug interaction studies are regularly conducted with conventional drugs (small molecules), but very few drug interaction studies have been performed with macromolecules (therapeutic proteins or monoclonal antibodies). This is mainly because most macromolecules are not metabolized by the cytochrome P450 system, and their mechanism of elimination is complex. However, it has been shown in several studies that interferons can have an impact on the cytochrome P450 system that may alter the pharmacokinetics and pharmacodynamics of a conventional drug when given with interferons. Therefore, it is important to evaluate the effect of other classes of macromolecules (cytokines, interleukins, monoclonal antibodies) on drug-metabolizing enzymes. It is also imperative that the effects of conventional drugs on the pharmacokinetics and pharmacodynamics of macromolecules be conducted. The present review encompasses several drug interaction studies that were conducted with macromolecules and highlights the impact of these studies on the pharmacokinetics and/or pharmacodynamics of the involved drugs. JF - Journal of clinical pharmacology AU - Mahmood, Iftekhar AU - Green, Martin David AD - Office of Blood Review & Research (OBRR), Center for Biologic Evaluation and Research, Food & Drug Administration, 1451 Rockville Pike, Rockville, MD 20850, USA. Iftekhar.mahmood@fda.hhs.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1540 EP - 1554 VL - 47 IS - 12 SN - 0091-2700, 0091-2700 KW - Antibodies, Monoclonal KW - 0 KW - Cytokines KW - Interleukins KW - Macromolecular Substances KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Cytokines -- therapeutic use KW - Cytokines -- pharmacokinetics KW - Humans KW - Interleukins -- therapeutic use KW - Interleukins -- pharmacokinetics KW - Interleukins -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Cytokines -- metabolism KW - Macromolecular Substances -- pharmacokinetics KW - Drug Interactions KW - Antibodies, Monoclonal -- pharmacokinetics KW - Antibodies, Monoclonal -- metabolism KW - Macromolecular Substances -- metabolism KW - Macromolecular Substances -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69003880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Drug+interaction+studies+of+therapeutic+proteins+or+monoclonal+antibodies.&rft.au=Mahmood%2C+Iftekhar%3BGreen%2C+Martin+David&rft.aulast=Mahmood&rft.aufirst=Iftekhar&rft.date=2007-12-01&rft.volume=47&rft.issue=12&rft.spage=1540&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-03 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lessons from the Avandia controversy: a new paradigm for the development of drugs to treat type 2 diabetes. AN - 68548960; 18042753 JF - Diabetes care AU - Misbin, Robert I AD - Division of Endocrinology and Metabolism, Food and Drug Administration, Silver Spring, Maryland, USA. robert.misbin@fda.hhs.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 3141 EP - 3144 VL - 30 IS - 12 KW - Hypoglycemic Agents KW - 0 KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - Index Medicus KW - United States KW - Hypoglycemic Agents -- therapeutic use KW - United States Food and Drug Administration KW - Humans KW - Drug Approval KW - Hypoglycemic Agents -- adverse effects KW - Clinical Trials as Topic -- standards KW - Meta-Analysis as Topic KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Thiazolidinediones -- adverse effects KW - Thiazolidinediones -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68548960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Lessons+from+the+Avandia+controversy%3A+a+new+paradigm+for+the+development+of+drugs+to+treat+type+2+diabetes.&rft.au=Misbin%2C+Robert+I&rft.aulast=Misbin&rft.aufirst=Robert&rft.date=2007-12-01&rft.volume=30&rft.issue=12&rft.spage=3141&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=1935-5548&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-08 N1 - Date created - 2007-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain. AN - 68538797; 17532111 AB - Adenosine A2A receptors localized in the dorsal striatum are considered as a new target for the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists has shown a significant improvement of the effects of l-DOPA. The present review emphasizes the possible application of A2A receptor antagonists in pathological conditions other than parkinsonism, including drug addiction, sleep disorders and pain. In addition to the dorsal striatum, the ventral striatum (nucleus accumbens) contains a high density of A2A receptors, which presynaptically and postsynaptically regulate glutamatergic transmission in the cortical glutamatergic projections to the nucleus accumbens. It is currently believed that molecular adaptations of the cortico-accumbens glutamatergic synapses are involved in compulsive drug seeking and relapse. Here we review recent experimental evidence suggesting that A2A antagonists could become new therapeutic agents for drug addiction. Morphological and functional studies have identified lower levels of A2A receptors in brain areas other than the striatum, such as the ventrolateral preoptic area of the hypothalamus, where adenosine plays an important role in sleep regulation. Although initially believed to be mostly dependent on A1 receptors, here we review recent studies that demonstrate that the somnogenic effects of adenosine are largely mediated by hypothalamic A2A receptors. A2A)receptor antagonists could therefore be considered as a possible treatment for narcolepsy and other sleep-related disorders. Finally, nociception is another adenosine-regulated neural function previously thought to mostly involve A1 receptors. Although there is some conflicting literature on the effects of agonists and antagonists, which may partly be due to the lack of selectivity of available drugs, the studies in A2A receptor knockout mice suggest that A2A receptor antagonists might have some therapeutic potential in pain states, in particular where high intensity stimuli are prevalent. JF - Progress in neurobiology AU - Ferré, S AU - Diamond, I AU - Goldberg, S R AU - Yao, L AU - Hourani, S M O AU - Huang, Z L AU - Urade, Y AU - Kitchen, I AD - Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, Department of Health and Human Services, Baltimore, MD 21224, USA. sferre@intra.nida.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 332 EP - 347 VL - 83 IS - 5 SN - 0301-0082, 0301-0082 KW - Adenosine A1 Receptor Antagonists KW - 0 KW - Adenosine A2 Receptor Antagonists KW - Receptor, Adenosine A1 KW - Receptor, Adenosine A2A KW - Adenosine KW - K72T3FS567 KW - Index Medicus KW - Neural Pathways -- physiopathology KW - Animals KW - Receptor, Adenosine A1 -- metabolism KW - Neural Pathways -- metabolism KW - Humans KW - Neural Pathways -- drug effects KW - Adenosine -- metabolism KW - Substance-Related Disorders -- physiopathology KW - Pain -- drug therapy KW - Pain -- physiopathology KW - Hypothalamus -- drug effects KW - Sleep Wake Disorders -- metabolism KW - Hypothalamus -- physiopathology KW - Receptor, Adenosine A2A -- metabolism KW - Sleep Wake Disorders -- physiopathology KW - Sleep Wake Disorders -- drug therapy KW - Hypothalamus -- metabolism KW - Substance-Related Disorders -- drug therapy KW - Basal Ganglia -- physiopathology KW - Substance-Related Disorders -- metabolism KW - Basal Ganglia -- drug effects KW - Pain -- metabolism KW - Basal Ganglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68538797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+neurobiology&rft.atitle=Adenosine+A2A+receptors+in+ventral+striatum%2C+hypothalamus+and+nociceptive+circuitry+implications+for+drug+addiction%2C+sleep+and+pain.&rft.au=Ferr%C3%A9%2C+S%3BDiamond%2C+I%3BGoldberg%2C+S+R%3BYao%2C+L%3BHourani%2C+S+M+O%3BHuang%2C+Z+L%3BUrade%2C+Y%3BKitchen%2C+I&rft.aulast=Ferr%C3%A9&rft.aufirst=S&rft.date=2007-12-01&rft.volume=83&rft.issue=5&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Progress+in+neurobiology&rft.issn=03010082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-04 N1 - Date created - 2007-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prog Neurobiol. 2004 Aug;73(6):379-96 [15313333] Alcohol Clin Exp Res. 2004 Sep;28(9):1308-16 [15365300] Eur J Neurosci. 2004 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[12445704] Pol J Pharmacol. 2002 Jul-Aug;54(4):359-66 [12523489] Eur J Pharmacol. 1994 May 12;257(1-2):21-5 [8082703] J Neurosci. 1994 Oct;14(10):6239-47 [7931576] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fatal falls overboard on commercial fishing vessels in Alaska. AN - 68531288; 17910031 AB - Falls overboard are a major contributor to commercial fishing fatalities in Alaska. The National Institute for Occupational Safety and Health has repeatedly identified falls overboard as a critical issue in commercial fishing safety. This article describes the problem of falls overboard and discusses possible ways to reduce the risk factors. Data from the Alaska Occupational Injury Surveillance System on fatal falls overboard in Alaska between 1990 and 2005 were used. An in-depth descriptive analysis of these fatalities was performed to identify areas for intervention. There were 71 fatal falls overboard on commercial fishing vessels in Alaska during the 16-year time period. Falls overboard did not decline significantly during those years. The most common circumstances associated with falling overboard were working with fishing gear, being alone on deck, losing balance or slipping, heavy weather, gear entanglement, and alcohol. The level of involvement of those circumstances varied by region and gear type. Many fatal falls overboard may be prevented by understanding the circumstances involved and targeting interventions at those specific risk factors. Interventions include creating more enclosed work spaces, managing lines, avoiding fishing alone, wearing personal flotation devices and man overboard alarms, and reducing alcohol use. Subsequent research should identify further interventions for each circumstance and evaluate the effectiveness of these interventions with the fishing industry. JF - American journal of industrial medicine AU - Lucas, Devin L AU - Lincoln, Jennifer M AD - National Institute for Occupational Safety and Health, Alaska Field Station, Anchorage, Alaska 99508, USA. dlucas@cdc.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 962 EP - 968 VL - 50 IS - 12 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Epidemiologic Studies KW - Risk Factors KW - Humans KW - Alaska -- epidemiology KW - Adult KW - Incidence KW - Middle Aged KW - Male KW - Female KW - Ships KW - Drowning -- epidemiology KW - Occupational Health KW - Drowning -- etiology KW - Accidental Falls -- mortality KW - Fisheries -- statistics & numerical data KW - Drowning -- mortality KW - Accidents, Occupational -- statistics & numerical data KW - Accidental Falls -- statistics & numerical data KW - Accidents, Occupational -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68531288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Fatal+falls+overboard+on+commercial+fishing+vessels+in+Alaska.&rft.au=Lucas%2C+Devin+L%3BLincoln%2C+Jennifer+M&rft.aulast=Lucas&rft.aufirst=Devin&rft.date=2007-12-01&rft.volume=50&rft.issue=12&rft.spage=962&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-20 N1 - Date created - 2007-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. AN - 68530329; 17875604 AB - The cystine-glutamate transporter SLC7A11 has been implicated in chemoresistance, by supplying cystine to the cell for glutathione maintenance. In the NCI-60 cell panel, SLC7A11 expression shows negative correlation with growth inhibitory potency of geldanamycin but not with its analog 17-(allylamino)-17-demethoxygeldanamycin (17-AAG), which differs in the C-17 substituent in that the the methoxy moiety of geldanamycin is replaced by an amino group. Structure and potency analysis classified 18 geldanamycin analogs into two subgroups, "17-O/H" (C-17 methoxy or unsubstituted) and "17-N" (C-17 amino), showing distinct SLC7A11 correlation. We used three 17-O/H analogs and four 17-N analogs to test the role of the 17-substituents in susceptibility to SLC7A11-mediated resistance. In A549 cells, which are resistant to geldanamycin and strongly express SLC7A11, inhibition of SLC7A11 by (S)-4-carboxyphenylglycine or small interfering RNA increased sensitivity to 17-O/H, but had no effect on 17-N analogs. Ectopic expression of SLC7A11 in HepG2 cells, which are sensitive to geldanamycin and express low SLC7A11, confers resistance to geldanamycin, but not to 17-AAG. Antioxidant N-acetylcysteine, a precursor for glutathione synthesis, completely suppressed cytotoxic effects of 17-O/H but had no effect on 17-N analogs, whereas the prooxidant ascorbic acid had the opposite effect. Compared with 17-AAG, geldanamycin led to significantly more intracellular reactive oxygen species (ROS) production, which was quenched by addition of N-acetylcysteine. We conclude that SLC7A11 confers resistance selectively to 17-O/H (e.g., geldanamycin) but not to 17-N (e.g., 17-AAG) analogs partly as a result of differential dependence on ROS for cytotoxicity. Distinct mechanisms could significantly affect antitumor response and organ toxicity of these compounds in vivo. JF - Molecular pharmacology AU - Liu, Ruqing AU - Blower, Paul E AU - Pham, Anh-Nhan AU - Fang, Jialong AU - Dai, Zunyan AU - Wise, Carolyn AU - Green, Bridgette AU - Teitel, Candee H AU - Ning, Baitang AU - Ling, Wenhua AU - Lyn-Cook, Beverly D AU - Kadlubar, Fred F AU - Sadée, Wolfgang AU - Huang, Ying AD - Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1637 EP - 1646 VL - 72 IS - 6 KW - Amino Acid Transport System y+ KW - 0 KW - Benzoquinones KW - Lactams, Macrocyclic KW - SLC7A11 protein, human KW - tanespimycin KW - 4GY0AVT3L4 KW - geldanamycin KW - Z3K3VJ16KU KW - Index Medicus KW - Humans KW - Cell Line, Tumor KW - Drug Screening Assays, Antitumor -- methods KW - Structure-Activity Relationship KW - Benzoquinones -- chemistry KW - Benzoquinones -- pharmacology KW - Lactams, Macrocyclic -- chemistry KW - Amino Acid Transport System y+ -- metabolism KW - Lactams, Macrocyclic -- pharmacology KW - Drug Resistance, Neoplasm -- physiology KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68530329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Cystine-glutamate+transporter+SLC7A11+mediates+resistance+to+geldanamycin+but+not+to+17-%28allylamino%29-17-demethoxygeldanamycin.&rft.au=Liu%2C+Ruqing%3BBlower%2C+Paul+E%3BPham%2C+Anh-Nhan%3BFang%2C+Jialong%3BDai%2C+Zunyan%3BWise%2C+Carolyn%3BGreen%2C+Bridgette%3BTeitel%2C+Candee+H%3BNing%2C+Baitang%3BLing%2C+Wenhua%3BLyn-Cook%2C+Beverly+D%3BKadlubar%2C+Fred+F%3BSad%C3%A9e%2C+Wolfgang%3BHuang%2C+Ying&rft.aulast=Liu&rft.aufirst=Ruqing&rft.date=2007-12-01&rft.volume=72&rft.issue=6&rft.spage=1637&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=1521-0111&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-04 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug interactions in the management of HIV infection: an update. AN - 68516515; 18001255 AB - Improvement in the availability of antiretroviral (ARV) therapy continues to reduce HIV morbidity and mortality. With more treatment choices and better accessibility, the extent of medication use among patients with HIV/AIDS continues to grow. ARV drugs are particularly prone to drug interactions as a consequence of their metabolic and pharmacokinetic properties. The recognition and management of drug interactions in patients on ARVs is a constant challenge to medical providers. Staying abreast of drug interaction knowledge is complicated by the rate at which new information becomes available through in vivo investigation, case reports and pharmacokinetic studies. In addition, distinguishing the clinical significance of an interaction is difficult due to the large interpatient variability in pharmacokinetics exhibited by most ARV agents. This review provides an update to a previous review article published in 2005, and is intended to improve the reader's knowledge of drug interactions in the management of HIV infection. JF - Expert opinion on pharmacotherapy AU - Robertson, Sarah M AU - Penzak, Scott R AU - Pau, Alice AD - US Food and Drug Administration, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Silver Spring, Maryland, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2947 EP - 2963 VL - 8 IS - 17 KW - Anti-HIV Agents KW - 0 KW - HIV Protease Inhibitors KW - Reverse Transcriptase Inhibitors KW - Index Medicus KW - Humans KW - Drug Monitoring KW - Treatment Outcome KW - Drug Interactions KW - Anti-HIV Agents -- pharmacokinetics KW - Reverse Transcriptase Inhibitors -- pharmacokinetics KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- drug therapy KW - HIV Infections -- metabolism KW - HIV Protease Inhibitors -- pharmacokinetics KW - HIV Protease Inhibitors -- therapeutic use KW - Reverse Transcriptase Inhibitors -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68516515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+pharmacotherapy&rft.atitle=Drug+interactions+in+the+management+of+HIV+infection%3A+an+update.&rft.au=Robertson%2C+Sarah+M%3BPenzak%2C+Scott+R%3BPau%2C+Alice&rft.aulast=Robertson&rft.aufirst=Sarah&rft.date=2007-12-01&rft.volume=8&rft.issue=17&rft.spage=2947&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+pharmacotherapy&rft.issn=1744-7666&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha. AN - 68473195; 17586532 AB - Peroxisome proliferators are potent rodent liver carcinogens that act via a non-genotoxic mechanism. The mode of action of these agents in rodent liver includes increased cell proliferation, decreased apoptosis, secondary oxidative stress and other events; however, it is not well understood how peroxisome proliferators are triggering the plethora of the molecular signals leading to cancer. Epigenetic changes have been implicated in the mechanism of liver carcinogenesis by a number of environmental agents. Short-term treatment with peroxisome proliferators and other non-genotoxic carcinogens leads to global and locus-specific DNA hypomethylation in mouse liver, events that were suggested to correlate with a burst of cell proliferation. In the current study, we investigated the effects of long-term exposure to a model peroxisome proliferator WY-14,643 on DNA and histone methylation. Male SV129mice were fed a control or WY-14,643-containing (1000ppm) diet for one week, five weeks or five months. Treatment with WY-14,643 led to progressive global hypomethylation of liver DNA as determined by an HpaII-based cytosine extension assay with the maximum effect reaching over 200% at five months. Likewise, trimethylation of histone H4 lysine 20 and H3 lysine 9 was significantly decreased at all time points. The majority of cytosine methylation in mammals resides in repetitive DNA sequences. In view of this, we measured the effect of WY-14,643 on the methylation status of major and minor satellites, as well as in IAP, LINE1 and LINE2 elements in liver DNA. Exposure to WY-14,643 resulted in a gradual loss of cytosine methylation in major and minor satellites, IAP, LINE1 and LINE2 elements. The epigenetic changes correlated with the temporal effects of WY-14,643 on cell proliferation rates in liver, but no sustained effect on c-Myc promoter methylation was observed. Finally, WY-14,643 had no effect on DNA and histone methylation status in Pparalpha-null mice at any of the time points considered in this study. These data indicate the importance of epigenetic alterations in the mechanism of action of peroxisome proliferators and the key role of Pparalpha. JF - Mutation research AU - Pogribny, Igor P AU - Tryndyak, Volodymyr P AU - Woods, Courtney G AU - Witt, Sarah E AU - Rusyn, Ivan AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 62 EP - 71 VL - 625 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Carcinogens KW - 0 KW - DNA Primers KW - Histones KW - PPAR alpha KW - Peroxisome Proliferators KW - Pyrimidines KW - Retroelements KW - pirinixic acid KW - 86C4MRT55A KW - Index Medicus KW - Animals KW - Base Sequence KW - Terminal Repeat Sequences -- drug effects KW - DNA Primers -- genetics KW - Histones -- metabolism KW - DNA Methylation -- drug effects KW - CpG Islands -- drug effects KW - Carcinogens -- toxicity KW - Retroelements -- drug effects KW - Long Interspersed Nucleotide Elements -- drug effects KW - Mice KW - Male KW - Mice, Knockout KW - PPAR alpha -- deficiency KW - Epigenesis, Genetic -- physiology KW - Liver -- drug effects KW - Pyrimidines -- toxicity KW - Peroxisome Proliferators -- toxicity KW - Epigenesis, Genetic -- drug effects KW - Liver -- metabolism KW - PPAR alpha -- metabolism KW - PPAR alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68473195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Epigenetic+effects+of+the+continuous+exposure+to+peroxisome+proliferator+WY-14%2C643+in+mouse+liver+are+dependent+upon+peroxisome+proliferator+activated+receptor+alpha.&rft.au=Pogribny%2C+Igor+P%3BTryndyak%2C+Volodymyr+P%3BWoods%2C+Courtney+G%3BWitt%2C+Sarah+E%3BRusyn%2C+Ivan&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2007-12-01&rft.volume=625&rft.issue=1-2&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13580-5 [16174748] J Mol Med (Berl). 2005 Oct;83(10):774-85 [15976920] Eur J Cancer. 2005 Nov;41(16):2381-402 [16226460] Nat Rev Genet. 2006 Jan;7(1):21-33 [16369569] EXS. 2006;(96):321-49 [16383025] Mutat Res. 2006 Jan 29;593(1-2):80-7 [16144704] Genome Res. 2006 Feb;16(2):157-63 [16365381] Nucleic Acids Res. 1997 Jun 15;25(12):2532-4 [9171110] Carcinogenesis. 1997 Nov;18(11):2029-33 [9395198] Biochem Biophys Res Commun. 1999 Sep 7;262(3):624-8 [10471374] Oncogene. 2004 Nov 18;23(54):8841-6 [15480421] Cell. 2004 Nov 24;119(5):603-14 [15550243] EMBO J. 2005 Feb 23;24(4):800-12 [15678104] Crit Rev Toxicol. 2005 Jan;35(1):61-88 [15742903] Nat Genet. 2005 Apr;37(4):391-400 [15765097] Toxicol Sci. 2005 Oct;87(2):344-52 [16014735] Toxicol Sci. 2006 Apr;90(2):269-95 [16322072] Toxicol Sci. 2006 Jun;91(2):393-405 [16537655] Carcinogenesis. 2006 Aug;27(8):1713-20 [16632870] Curr Top Microbiol Immunol. 2006;310:211-50 [16909913] Curr Top Microbiol Immunol. 2006;310:251-74 [16909914] Anal Biochem. 2006 Sep 15;356(2):202-7 [16824473] Crit Rev Toxicol. 2006 May;36(5):459-79 [16954067] J Nutr. 2007 Jan;137(1 Suppl):216S-222S [17182829] Cancer Res. 2007 Feb 1;67(3):946-50 [17283125] Mol Carcinog. 2007 Mar;46(3):187-97 [17219426] Toxicol Sci. 2007 Aug;98(2):366-74 [17483499] Regul Toxicol Pharmacol. 2000 Oct;32(2):135-43 [11067770] Carcinogenesis. 2000 Dec;21(12):2141-5 [11133801] Antioxid Redox Signal. 2000 Fall;2(3):607-21 [11229371] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3375-80 [11248086] Toxicol Sci. 2001 Jul;62(1):28-35 [11399790] Cell. 2001 Nov 2;107(3):323-37 [11701123] Mol Cell Biol. 2002 Jan;22(2):480-91 [11756544] Annu Rev Pharmacol Toxicol. 2002;42:501-25 [11807181] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10060-5 [12110732] Toxicol Lett. 2002 Aug 5;134(1-3):51-6 [12191860] Toxicol Sci. 2003 Oct;75(2):289-99 [12883089] Adv Cancer Res. 2003;90:209-30 [14710952] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] EMBO J. 2004 Feb 11;23(3):605-15 [14765126] Science. 2004 Mar 12;303(5664):1626-32 [15016989] J Cell Sci. 2004 May 15;117(Pt 12):2491-501 [15128874] Nucleic Acids Res. 2004;32(14):4100-8 [15302911] Cancer Res. 1979 Jan;39(1):152-61 [83907] Mol Cell Biol. 1995 Jun;15(6):3012-22 [7539101] Cancer Res. 1997 Feb 15;57(4):594-9 [9044832] Mutat Res. 1997 Apr;386(2):141-52 [9113115] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Uncertainty determination for nondestructive chemical analytical methods using field data and application to XRF analysis for lead. AN - 68428524; 17957563 AB - Air sampling and analytical methods are developed to provide a basis for decision making. They are evaluated in the laboratory against prescribed fitness-for-use criteria even though laboratory validation does not take into account all possible sources of uncertainty in field application. Field evaluation would be preferable but is complicated by the lack of controlled conditions, which limits the ability to compare analytical methods and to recognize outliers and assess variance homogeneity across the range of interest. The specific situation of evaluating nondestructive field analytical methods against their reference laboratory equivalent is considered here, since the difficulty of providing replicates is obviated in this case. A portable X-ray fluorescence (XRF) analyzer was used to determine the lead content of air filter samples from several workplaces where lead is used or is a contaminant of the process material. The portable XRF method has the advantage of allowing for faster decisions compared with the alternative of submitting the air samples to an off-site laboratory for analysis. Since the XRF method is nondestructive, the same air samples were also subjected to the reference laboratory-based method of analysis. Two statistical approaches were developed specifically to deal with non-normal elements of the data in evaluating the results. The ISO GUM method identifies outliers and then calculates an accuracy range about the true concentration for the remainder of the data. This coverage is then adjusted to account for the rate of outlier occurrence. The bootstrap procedure uses a large number of computer-generated data points that are sampled, with replacement, from the original set including outliers to determine the coverage. No significant difference is seen between the two statistical approaches. Both approaches result in similar coverage and support the adoption of method acceptance criteria specific to field evaluation (a symmetric accuracy range of 35%). The portable XRF analyzer met this criterion when used with several different sampling methods and thus could be used as a method for routine evaluation of compliance with lead limit values. As the method is nondestructive, further analysis of air samples with analytical results near decision points is possible. JF - Journal of occupational and environmental hygiene AU - Bartley, David L AU - Slaven, James E AU - Rose, Mike C AU - Andrew, Michael E AU - Harper, Martin AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 931 EP - 942 VL - 4 IS - 12 SN - 1545-9624, 1545-9624 KW - Air Pollutants, Occupational KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Threshold Limit Values KW - Sensitivity and Specificity KW - Humans KW - Confidence Intervals KW - Metallurgy KW - Spectrometry, X-Ray Emission -- instrumentation KW - Air Pollutants, Occupational -- analysis KW - Lead -- analysis KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- methods KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68428524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Uncertainty+determination+for+nondestructive+chemical+analytical+methods+using+field+data+and+application+to+XRF+analysis+for+lead.&rft.au=Bartley%2C+David+L%3BSlaven%2C+James+E%3BRose%2C+Mike+C%3BAndrew%2C+Michael+E%3BHarper%2C+Martin&rft.aulast=Bartley&rft.aufirst=David&rft.date=2007-12-01&rft.volume=4&rft.issue=12&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-31 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification and characterization of potential sources of worker exposure to carbon nanofibers during polymer composite laboratory operations. AN - 68417358; 17943583 JF - Journal of occupational and environmental hygiene AU - Methner, Mark M AU - Birch, M Eileen AU - Evans, Douglas E AU - Ku, Bon-Ki AU - Crouch, Keith AU - Hoover, Mark D AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - D125 EP - D130 VL - 4 IS - 12 SN - 1545-9624, 1545-9624 KW - Air Pollutants, Occupational KW - 0 KW - Particulate Matter KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Protective Clothing KW - Manufactured Materials -- analysis KW - Humans KW - Environmental Exposure KW - Occupational Exposure -- analysis KW - Risk Assessment KW - Air Pollutants, Occupational -- analysis KW - Metal Nanoparticles -- analysis KW - Carbon -- analysis KW - Particulate Matter -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68417358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Identification+and+characterization+of+potential+sources+of+worker+exposure+to+carbon+nanofibers+during+polymer+composite+laboratory+operations.&rft.au=Methner%2C+Mark+M%3BBirch%2C+M+Eileen%3BEvans%2C+Douglas+E%3BKu%2C+Bon-Ki%3BCrouch%2C+Keith%3BHoover%2C+Mark+D&rft.aulast=Methner&rft.aufirst=Mark&rft.date=2007-12-01&rft.volume=4&rft.issue=12&rft.spage=D125&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-31 N1 - Date created - 2007-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Nanoparticle Information Library (NIL): a prototype for linking and sharing emerging data. AN - 68364845; 17924276 JF - Journal of occupational and environmental hygiene AU - Miller, Arthur L AU - Hoover, Mark D AU - Mitchell, David M AU - Stapleton, Brian P AD - National Institute for Occupational Safety and Health, Spokane, WA, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - D131 EP - D134 VL - 4 IS - 12 SN - 1545-9624, 1545-9624 KW - Index Medicus KW - United States KW - Registries KW - Cooperative Behavior KW - Humans KW - Information Dissemination KW - Databases, Factual KW - Manufactured Materials KW - Information Storage and Retrieval KW - Internet KW - Nanoparticles -- statistics & numerical data KW - Libraries KW - Nanoparticles -- adverse effects KW - National Institute for Occupational Safety and Health (U.S.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68364845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=The+Nanoparticle+Information+Library+%28NIL%29%3A+a+prototype+for+linking+and+sharing+emerging+data.&rft.au=Miller%2C+Arthur+L%3BHoover%2C+Mark+D%3BMitchell%2C+David+M%3BStapleton%2C+Brian+P&rft.aulast=Miller&rft.aufirst=Arthur&rft.date=2007-12-01&rft.volume=4&rft.issue=12&rft.spage=D131&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-31 N1 - Date created - 2007-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic lymphocytic leukemia radiogenicity: a systematic review. AN - 68332371; 17694421 AB - Chronic lymphocytic leukemia (CLL) is generally considered to be non-radiogenic and is excluded from several programs that compensate workers for illnesses resulting from occupational exposures. Questions about whether this exclusion is justified prompted a Congressional mandate to the National Institute for Occupational Safety and Health (NIOSH) to, further, examine the radiogenicity of CLL. This study revisits the question of CLL radiogenicity by examining epidemiologic evidence from occupationally and medically-exposed populations. A systematic review of radiation-exposed cohorts was conducted to investigate the association between radiation and CLL. Exploratory power calculations for a pooled occupational study were performed to examine the feasibility of assessing CLL radiogenicity epidemiologically. There is a bias against reporting CLL results, because of the disease's presumed non-radiogenicity. In medical cohort studies that provide risk estimates for CLL, risk is elevated, though non-significantly, in almost all studies with more than 15 years average follow-up. The results of occupational studies are less consistent. Studies with adequate follow-up time and power are needed to better understand CLL radiogenicity. Power analyses show that a pooled study might detect risk on the order of radiation induced non-CLL leukemia, but is unlikely to detect smaller risks. JF - Cancer causes & control : CCC AU - Silver, Sharon R AU - Hiratzka, Shannon L AU - Schubauer-Berigan, Mary K AU - Daniels, Robert D AD - Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, USA. ssilver@cdc.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1077 EP - 1093 VL - 18 IS - 10 SN - 0957-5243, 0957-5243 KW - Index Medicus KW - United States KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Leukemia, Lymphocytic, Chronic, B-Cell -- epidemiology KW - Neoplasms, Radiation-Induced -- epidemiology KW - Occupational Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68332371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Chronic+lymphocytic+leukemia+radiogenicity%3A+a+systematic+review.&rft.au=Silver%2C+Sharon+R%3BHiratzka%2C+Shannon+L%3BSchubauer-Berigan%2C+Mary+K%3BDaniels%2C+Robert+D&rft.aulast=Silver&rft.aufirst=Sharon&rft.date=2007-12-01&rft.volume=18&rft.issue=10&rft.spage=1077&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=09575243&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-11 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Spousal concordance for substance use and anxiety disorders. AN - 68182937; 17204289 AB - Assortative mating -- the tendency for mate selection to occur on the basis of similar traits -- plays an essential role in understanding the genetic contribution to psychiatric illness. It also carries significant impact on clinical prognosis and is an important mechanism explaining spousal concordance. This study uses a family study design ascertaining 225 probands with substance abuse/dependence, anxiety disorders, and controls to address: (1) Is there spousal concordance or cross-concordance for substance use and/or anxiety disorders? (2) Is the spousal concordance or cross-concordance associated with worse clinical outcomes? (3) What is the mechanism of the concordance or cross-concordance? Results show a high magnitude of spousal concordance for substance use disorders with a third of the substance probands' spouses also substance dependent. In contrast, there was no spousal concordance for anxiety disorders. Couples were also concordant for having "no disorders." Both substance use and anxiety disorder concordance were associated with poorer global functioning and persistent illness. Assortative mating is a likely mechanism for spousal concordance given the elevated rate of substance use disorders among the relatives of spouses' of substance probands. Implications for family/genetic studies and the transmission of substance use disorders and "no disorders" include: (1) at the individual level, spousal concordance influences probands' course of illness, couples' marital functioning, and offspring's genetic and environmental context; and (2) at the population level, it shifts the general distribution of substance use disorders and "no disorders" by reducing the "average" couple concordance and increasing the number concordant and discordant couples at extremes of the distribution. JF - Journal of psychiatric research AU - Low, Nancy AU - Cui, Lihong AU - Merikangas, Kathleen R AD - Section on Developmental Genetic Epidemiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-3720, USA. Nancy.Low@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 942 EP - 951 VL - 41 IS - 11 SN - 0022-3956, 0022-3956 KW - Index Medicus KW - Humans KW - Marriage -- statistics & numerical data KW - Comorbidity KW - Mood Disorders -- genetics KW - Phenotype KW - Interview, Psychological KW - Marriage -- psychology KW - Genetic Predisposition to Disease -- genetics KW - Risk Factors KW - Adult KW - Middle Aged KW - Mood Disorders -- epidemiology KW - Mood Disorders -- psychology KW - Female KW - Male KW - Anxiety Disorders -- genetics KW - Alcoholism -- epidemiology KW - Anxiety Disorders -- psychology KW - Spouses -- statistics & numerical data KW - Spouses -- psychology KW - Substance-Related Disorders -- psychology KW - Anxiety Disorders -- epidemiology KW - Alcoholism -- genetics KW - Alcoholism -- psychology KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68182937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychiatric+research&rft.atitle=Spousal+concordance+for+substance+use+and+anxiety+disorders.&rft.au=Low%2C+Nancy%3BCui%2C+Lihong%3BMerikangas%2C+Kathleen+R&rft.aulast=Low&rft.aufirst=Nancy&rft.date=2007-12-01&rft.volume=41&rft.issue=11&rft.spage=942&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychiatric+research&rft.issn=00223956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Understanding the Relative Influence of Neighborhood, Family, and Youth on Adolescent Drug Use AN - 61432843; 200804746 AB - In the United States, a variety of programs have been developed to prevent substance use among youth. These programs often target youth directly, and may also have components that address the relational influence of families, schools, and communities. We discuss clustering of youth marijuana use within and between households and neighborhoods. As often discussed in the literature, we consider analyzing 'components of variance' in a hierarchical sample design with two or more levels. With a continuous outcome variable, the estimated relative size of variance components at each level can be interpreted as its relative 'importance.' We estimate variance components when the outcome is dichotomous, and find that for the use of marijuana in the past year, the role of the individual (individual adolescent vs. role of household vs. role of neighborhood) is quite prominent (79% of variation). A similar result is observed for the continuous scale variable of individual positive attitudes toward drug use (83%). For continuous constructs related to either household (parental monitoring) or neighborhood (neighborhood disorganization) the majority of variation still occurs at the individual level (67% and 51%, respectively), although they reveal significant percent variation (about 30%) at the corresponding family or neighborhood levels as well. We discuss the use of variance component methodology and the relevance for prevention programs. Adapted from the source document. JF - Substance Use & Misuse AU - Wright, Douglas A AU - Bobashev, Georgiy AU - Folsom, Ralph AD - Office of Applied Studies (OAS), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, Maryland, USA Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2159 EP - 2171 PB - Taylor & Francis, Philadelphia PA VL - 42 IS - 14 SN - 1082-6084, 1082-6084 KW - Prevention KW - Substance Abuse KW - Family Relations KW - United States of America KW - Marijuana KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61432843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Understanding+the+Relative+Influence+of+Neighborhood%2C+Family%2C+and+Youth+on+Adolescent+Drug+Use&rft.au=Wright%2C+Douglas+A%3BBobashev%2C+Georgiy%3BFolsom%2C+Ralph&rft.aulast=Wright&rft.aufirst=Douglas&rft.date=2007-12-01&rft.volume=42&rft.issue=14&rft.spage=2159&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1080%2F10826080701212675 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-09-03 N1 - Number of references - 22 N1 - Last updated - 2016-09-28 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Marijuana; Family Relations; United States of America; Substance Abuse; Prevention DO - http://dx.doi.org/10.1080/10826080701212675 ER - TY - JOUR T1 - Crossing the Line: Observations from East Detroit, Michigan, USA AN - 61420955; 200907042 AB - This is an experimental piece that reports on findings from a research project conducted from September to December 2006 on the border between a neighborhood on the east side of Detroit (Jefferson Chalmers) and Grosse Pointe Park, Michigan. The project addresses the stark racial, economic, and physical divides between two proximate communities, and the way that the boundary line between these communities is enacted. Alter Road, serves as this real and infrequently crossed border. The physical barriers put in place to reinforce the imaginary line between East Detroit,1 and Grosse Pointe Park and the conditions on either side of the border are prominent themes. For social workers, understanding how and why bordering communities remain insular, and the effect of that segregation, is important in understanding human behavior and better appreciating the circumstances from which people come. This qualitative piece illustrates these issues through the eyes of a graduate social work student walking again and again across that boundary. [Reprinted by permission of Sage Publications Ltd., copyright 2007.] JF - Qualitative Social Work AU - Martin, Megan C AD - Department of Health and Human Services, Washington, DC, USA megcmartin@gmail.com Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 465 EP - 475 PB - Sage Publications, London UK VL - 6 IS - 4 SN - 1473-3250, 1473-3250 KW - borders neighborhood observational research race KW - Borders KW - Neighborhoods KW - Race KW - Detroit, Michigan KW - article KW - 6111: social work theory/research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61420955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Social+Work&rft.atitle=Crossing+the+Line%3A+Observations+from+East+Detroit%2C+Michigan%2C+USA&rft.au=Martin%2C+Megan+C&rft.aulast=Martin&rft.aufirst=Megan&rft.date=2007-12-01&rft.volume=6&rft.issue=4&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Qualitative+Social+Work&rft.issn=14733250&rft_id=info:doi/10.1177%2F1473325007083357 LA - English DB - Social Services Abstracts N1 - Date revised - 2009-10-02 N1 - Number of references - 4 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Detroit, Michigan; Race; Neighborhoods; Borders DO - http://dx.doi.org/10.1177/1473325007083357 ER - TY - JOUR T1 - Selection into specialty training in public health: performance of the Medical Training Application Service shortlisting AN - 57253381; 200816438 AB - Objective: To assess the performance of shortlisting against appointability to public health specialty training under the Medical Training Application Service (MTAS) selection methodology using multiple modality in person assessment. Methods: Candidates who had applied to public health specialty training programme in Wales and East of England and shortlisted were assessed in the first assessment round. Further to MTAS review, candidates not previously short listed were offered assessment in the second round. Receiver operating characteristic (ROC) analysis was done. Results: In both the programmes, the shortlisting scores of candidates considered appointable were substantially higher than those considered not appointable, a score difference of 13.0 (95% confidence interval (CI) 3.0-23.0) and 13.5 (95% CI 3.4-23.5) respectively. The area under the ROC curve (ROCAUC) was 0.88 (95% CI 0.63-1.00) in Wales and 0.77 (95% CI 0.57-0.97) in East of England. The shortlisting scores of the two programmes that gave an optimum performance (maximum sum of the sensitivity and specificity) were comparable (scores of 62 and 63 respectively). Conclusion: MTAS shortlisting undertaken in two independent public health specialty training programmes discriminated well between appointable and not appointable candidates. Adapted from the source document. JF - Journal of Public Health AU - Pashayan, Nora AU - Duff, Celia AU - Mason, Brendan W AD - National Public Health Service for Wales, The Temple of Peace and Health, Cathays Parks, Cardiff CF10 3NW, UK Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 331 EP - 337 PB - Oxford University Press VL - 29 IS - 4 SN - 1741-3842, 1741-3842 KW - medical training application service (MTAS), specialty training, postgraduate medical education, assessment centre, receiver operating characteristic analysis KW - Assessment KW - Receiver operating characteristic analysis KW - Training KW - Application KW - Specialization KW - Medical education KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health&rft.atitle=Selection+into+specialty+training+in+public+health%3A+performance+of+the+Medical+Training+Application+Service+shortlisting&rft.au=Pashayan%2C+Nora%3BDuff%2C+Celia%3BMason%2C+Brendan+W&rft.aulast=Pashayan&rft.aufirst=Nora&rft.date=2007-12-01&rft.volume=29&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health&rft.issn=17413842&rft_id=info:doi/10.1093%2Fpubmed%2Ffdm060 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Receiver operating characteristic analysis; Specialization; Training; Medical education; Assessment; Application DO - http://dx.doi.org/10.1093/pubmed/fdm060 ER - TY - JOUR T1 - Needle-stick injuries in primary care in Wales AN - 57251116; 200815765 AB - Background: Accidental needle-stick injuries (NSIs) are a hazard for health-care workers and for the general public. Objectives: To estimate the presentation rate of NSIs to general medical practices, their relation to practice characteristics, and review practice policies for managing NSIs. Method: Descriptive study using logistic regression analysis. Results: Annual rates of 2.73 (95% CI 2.08, 3.50) occupational NSIs per 100 clinical practice staff and 2.14 (95% CI 1.39, 3.13) non-occupational NSIs per 100 000 practice population were recorded. Stepwise logistic regressions showed that chance of a practice reporting at least one occupational NSI in previous five years was best predicted by being a single-handed practice (decreased odds). In contrast, the chance of a practice reporting at least one non-occupational NSI was best predicted by being a rural practice (increased odds). About one in five practices possessed no written policy on managing NSIs. Stepwise logistic regressions showed that the chance of a practice owning a NSI policy was best predicted by being located in an LHB area with a coastline (increased odds). Conclusion: NSIs are an important public health issue in Wales. We have tried to address the lack of guidance by developing new guidelines in Wales. Adapted from the source document. JF - Journal of Public Health AU - Atenstaedt, R L AU - Payne, S AU - Roberts, R J AU - Russell, I T AU - Russell, D AU - Edwards, R T AD - National Public Health Service for Wales, UK robert.atenstaedt@nphs.wales.nhs.uk Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 434 EP - 440 PB - Oxford University Press VL - 29 IS - 4 SN - 1741-3842, 1741-3842 KW - general practice, needle-stick injury, primary care, public health KW - Needles KW - Penetrating injuries KW - General practice KW - Primary health care KW - Wales KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57251116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health&rft.atitle=Needle-stick+injuries+in+primary+care+in+Wales&rft.au=Atenstaedt%2C+R+L%3BPayne%2C+S%3BRoberts%2C+R+J%3BRussell%2C+I+T%3BRussell%2C+D%3BEdwards%2C+R+T&rft.aulast=Atenstaedt&rft.aufirst=R&rft.date=2007-12-01&rft.volume=29&rft.issue=4&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health&rft.issn=17413842&rft_id=info:doi/10.1093%2Fpubmed%2Ffdm048 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Public health; Wales; Needles; Primary health care; General practice; Penetrating injuries DO - http://dx.doi.org/10.1093/pubmed/fdm048 ER - TY - JOUR T1 - Occupational and Non-Occupational Injuries in the United States Army: Focus on Gender AN - 57231500; 200805319 AB - Background The differences in occupational and non-occupational injuries between military men and women have not been documented. This study compares occupational and non-occupational injuries between male and female United States Army soldiers by examining injury hospitalization rates and characteristics. Methods The U.S. Army's Total Army Injury and Health Outcomes Database was searched for hospitalizations with ICD-9-CM codes for injury (800-959.9) between 1992 and 2002. Injury rates were calculated using yearly U.S. Army population data and compared using rate ratios. Injury characteristics were compared among categories of the Trauma Code (on duty; off duty; scheduled training, schemes, and exercises), stratified by gender. Results Included in this analysis were 792 women for an injury hospitalization rate of 11.0 per 1000 individuals (95% confidence interval [CI]=8.5-13.5) and 4879 men for a rate of 15.5 per 1000 individuals (95% CI=14.0-16.9). While women had significantly more injuries during scheduled training, schemes, and exercises than men (p<0.0001), there were few differences in the cause of those injuries. Women had longer average hospital stays compared to men due to these injuries (9.3 days vs 7.4 days, p=0.002), although these injuries were not more severe (average Injury Severity Score=3.5 for men vs average ISS for women=3.5, p=0.79). There was no difference between the genders in the percent of injuries that occurred off duty; however, men were more likely to get injured due to sports and athletics (p=0.001) and due to fighting (p=0.017) while off duty compared to women. Conclusions Injury prevention messages for military personnel should focus on reducing risk factors for both on- and off-duty injuries. [Copyright 2007 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Tiesman, Hope M AU - Peek-Asa, Corinne L AU - Zwerling, Craig S AU - Sprince, Nancy L AU - Amoroso, Paul J AD - National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, West Virginia htiesman@cdc.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 464 EP - 470 PB - Elsevier Science, New York NY VL - 33 IS - 6 SN - 0749-3797, 0749-3797 KW - Hospitalization KW - Injuries KW - Industrial accidents KW - Soldiers KW - Out of working hours KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57231500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Occupational+and+Non-Occupational+Injuries+in+the+United+States+Army%3A+Focus+on+Gender&rft.au=Tiesman%2C+Hope+M%3BPeek-Asa%2C+Corinne+L%3BZwerling%2C+Craig+S%3BSprince%2C+Nancy+L%3BAmoroso%2C+Paul+J&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2007-12-01&rft.volume=33&rft.issue=6&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2007.07.034 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Industrial accidents; Injuries; Soldiers; Gender differences; Out of working hours; Hospitalization DO - http://dx.doi.org/10.1016/j.amepre.2007.07.034 ER - TY - CPAPER T1 - Cbl-dependent Regulation of LAT-nucleated Signaling Complexes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39582675; 4738737 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Balagopalan, L AU - Barr, V A AU - Sommers, C L AU - Barda-Saad, M AU - Goyal, A AU - Isakowitz, M E AU - Samelson, L E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39582675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cbl-dependent+Regulation+of+LAT-nucleated+Signaling+Complexes&rft.au=Balagopalan%2C+L%3BBarr%2C+V+A%3BSommers%2C+C+L%3BBarda-Saad%2C+M%3BGoyal%2C+A%3BIsakowitz%2C+M+E%3BSamelson%2C+L+E&rft.aulast=Balagopalan&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - RPRT T1 - Table of contents AN - 236493173 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236493173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-12-01&rft.volume=&rft.issue=545&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2007 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDY OF GENISTEIN (CAS NO. 446-72-0) IN SPRAGUE-DAWLEY RATS (FEED STUDY) AN - 236471144; 18685716 AB - Genistein is an isoflavone that occurs in soy products including soy-based infant formulas. Genistein is one of a class of chemicals known as "environmental estrogens" which can affect the homione activities and possibly reproductive function of wildlife and humans through exposure. The NTP conducted a series of studies on three such chemicals to detect if exposure to such chemicals over the course of multiple generations could have any cumulative effect on animals' reproductive systems or development of cancers. This report describes the results of a set of studies in which rats were exposed to genistein for part or all of the study period and examined at the end of two years. The study consisted of three separate study components; in each, animals were exposed to genistein from the time of conception and through weaning through theft mothers, who were given genistein in their feed. In one study, we gave feed containing 5, 100, or 500 parts per million (ppm) of genistein to groups of 50 male and female rats from conception through two years. In the second study, groups of 50 male and female rats were given the same feed concentrations up to 20 weeks following birth, followed by untreated feed for the remainder of the two years. In the third study, groups of 50 male and female rats were exposed from conception through weaning, and then given untreated feed for the duration of the study. Control animals received the same feed with no chemical added. At the end of the study, tissues from more than 40 sites were examined for every animal. In none of the three studies were there any increased rates of cancer in male rats. In female rats exposed to genistein from conception and throughout two years, the rates of adenoma or adenocarcinoma of the mammary gland and pituitary gland adenoma or carcinoma were increased. In female rats exposed to genistein for 20 weeks following birth, the rates of pituitary gland adenoma or carcinoma were slightly increased, and in female rats exposed to genistein just from conception through weaning, the rates of mammary gland adenoma or adenocarcinoma were slightly increased. We conclude that exposure to genistein for two years caused tumors of the mammary gland and pituitary gland in female rats. Exposure to genistein for shorter durations following birth was also possibly associated with increased rates of pituitary gland and mammary gland tumors. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1 EP - 240 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Phytoestrogens KW - Xenobiotics KW - Genistein KW - Toxicology KW - Carcinogens KW - Rodents KW - Chemicals KW - Pituitary gland KW - Pituitary Neoplasms -- chemically induced KW - Animals KW - Litter Size -- drug effects KW - Kidney -- pathology KW - Mammary Glands, Animal -- drug effects KW - Mammary Neoplasms, Animal -- pathology KW - Longevity -- drug effects KW - Kidney -- drug effects KW - Mammary Neoplasms, Animal -- chemically induced KW - Neoplasms, Experimental -- pathology KW - Estrous Cycle -- drug effects KW - Pregnancy KW - Rats KW - Prenatal Exposure Delayed Effects -- pathology KW - Rats, Sprague-Dawley KW - Pituitary Neoplasms -- pathology KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Mammary Glands, Animal -- pathology KW - Body Weight -- drug effects KW - Female KW - Male KW - Phytoestrogens -- toxicity KW - Reproduction -- drug effects KW - Neoplasms, Experimental -- etiology KW - Toxicity Tests, Chronic KW - Genistein -- toxicity KW - Xenobiotics -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236471144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDY+OF+GENISTEIN+%28CAS+NO.+446-72-0%29+IN+SPRAGUE-DAWLEY+RATS+%28FEED+STUDY%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-12-01&rft.volume=&rft.issue=545&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2007 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 236458206 AB - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236458206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-12-01&rft.volume=&rft.issue=545&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2007 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - A Laboratory Preparation of Aspartame Analogs Using Simultaneous Multiple Parallel Synthesis Methodology AN - 211952861 AB - Solid-phase peptide synthesis (SPPS), pioneered by Merrifield in 1963, is an essential method for synthesizing peptides in the laboratory. In SPPS the "solid state" is a polymeric resin bead with a functional group to which amino acids are chemically attached one-by-one until the desired peptide sequence is achieved. Here, Qvit et al detail how the synthesis and characterization of three dipeptide analogs of aspartame is demonstrated using the tea bag methodology, and how solid-phase methodology using the Fmoc chemistry is employed in this experiment. JF - Journal of Chemical Education AU - Qvit, Nir AU - Barda, Yaniv AU - Gilon, Chaim AU - Shalev, Deborah E Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1988 CY - Easton PB - American Chemical Society VL - 84 IS - 12 SN - 00219584 KW - Chemistry KW - Peptides KW - Amino acids KW - Chemical synthesis KW - Biochemistry KW - Artificial sweeteners UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/211952861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aeducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chemical+Education&rft.atitle=A+Laboratory+Preparation+of+Aspartame+Analogs+Using+Simultaneous+Multiple+Parallel+Synthesis+Methodology&rft.au=Qvit%2C+Nir%3BBarda%2C+Yaniv%3BGilon%2C+Chaim%3BShalev%2C+Deborah+E&rft.aulast=Qvit&rft.aufirst=Nir&rft.date=2007-12-01&rft.volume=84&rft.issue=12&rft.spage=1988&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chemical+Education&rft.issn=00219584&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Chemical Society Dec 2007 N1 - Document feature - References; Diagrams N1 - Last updated - 2014-05-18 N1 - CODEN - JCEDA8 ER - TY - JOUR T1 - Litterfall production in the Brazilian mid-western Amazonia-Cerrado transition forest TT - Producao de serrapilheira no Cerrado e Floresta de Transicao Amazonia-Cerrado do Centro-Oeste Brasileiro AN - 20973035; 8542956 AB - (Litterfall production in the Brazilian mid-western Amazonia-Cerrado transition forest). The objective of the present work was to verify the variation of litterfall production of different biomass: a cerrado ("savanna") with vegetation types Cerrado sensu stricto ("orchard-like vegetation") and Cerradao ("woodland-like vegetation") and Amazonia-Cerrado transition forest in a tropical climate. To determine the litterfall production, we used nylon screen traps. Micrometereologic data was collected in both areas of study. The litterfall in two biomass revealed diemselves as seasonal, with the highest productions occurring during the dry season and the lowest during the wet. The biggest litterfall occurred in the Transition Forest, followed by the Cerrado biome. Leaf fraction was more representative than twigs, flowers, fruits in both areas studied. JF - Acta Amazonica AU - da Silva, CJ AU - Sanches, L AU - Bleich, ME AU - Lobo, FDA AU - Nogueira, JDS AD - Universidade do Estado de Mato Grosso, Campus de Alta Floresta, Departamento de Engenharia Florestal, cjsnx@yahoo.com.br Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 543 EP - 548 VL - 37 IS - 4 SN - 0044-5967, 0044-5967 KW - Ecology Abstracts KW - Fruits KW - Flowers KW - Data processing KW - Climate KW - Traps KW - Vegetation KW - Forests KW - Biomass KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20973035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Amazonica&rft.atitle=Litterfall+production+in+the+Brazilian+mid-western+Amazonia-Cerrado+transition+forest&rft.au=da+Silva%2C+CJ%3BSanches%2C+L%3BBleich%2C+ME%3BLobo%2C+FDA%3BNogueira%2C+JDS&rft.aulast=da+Silva&rft.aufirst=CJ&rft.date=2007-12-01&rft.volume=37&rft.issue=4&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Acta+Amazonica&rft.issn=00445967&rft_id=info:doi/ LA - Portuguese DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Forests; Vegetation; Biomass; Traps; Data processing; Fruits; Climate; Flowers ER - TY - JOUR T1 - Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma AN - 20724372; 7933525 AB - A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma. JF - Carcinogenesis AU - Brenner, A V AU - Butler, MA AU - Wang, S S AU - Ruder, A M AU - Rothman, N AU - Schulte, P A AU - Chanock, S J AU - Fine, HA AU - Linet AU - Inskip, P D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. Division of Applied Research and Technology, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Education and Information Division, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Core Genotyping Facility, Advanced Technology Corporation, National Cancer Institute, NIH, DHHS, Gaithersburg, MD, 20892-4605, USA. Neurooncology Branch, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD, 20892-8200, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2543 EP - 2547 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 12 SN - 0143-3334, 0143-3334 KW - Health & Safety Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - Interleukin 6 KW - Historical account KW - Interleukin 4 KW - Etiology KW - Occupational safety KW - Autoimmune diseases KW - autoimmune diseases KW - Population studies KW - Allergies KW - Cancer KW - Brain tumors KW - glioma KW - Hypersensitivity KW - Single-nucleotide polymorphism KW - Carcinogenesis KW - Cytokines KW - Glioma KW - G 07720:Immunogenetics KW - F 06925:Hypersensitivity KW - H 1000:Occupational Safety and Health KW - N 14845:Miscellaneous KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Single-nucleotide+polymorphisms+in+selected+cytokine+genes+and+risk+of+adult+glioma&rft.au=Brenner%2C+A+V%3BButler%2C+MA%3BWang%2C+S+S%3BRuder%2C+A+M%3BRothman%2C+N%3BSchulte%2C+P+A%3BChanock%2C+S+J%3BFine%2C+HA%3BLinet%3BInskip%2C+P+D&rft.aulast=Brenner&rft.aufirst=A&rft.date=2007-12-01&rft.volume=28&rft.issue=12&rft.spage=2543&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Brain tumors; Etiology; Hypersensitivity; Interleukin 4; Single-nucleotide polymorphism; Autoimmune diseases; Carcinogenesis; Population studies; Cytokines; Glioma; Historical account; glioma; Occupational safety; autoimmune diseases; Allergies; Cancer ER - TY - JOUR T1 - beta -Ionone reactions with ozone and OH radical: Rate constants and gas-phase products AN - 20692308; 8182568 AB - The bimolecular rate constants, k sub(O) sub(H) sub(?) sub(+) sub( beta ) sub(-) sub(i) sub(o) sub(n) sub(o) sub(n) sub(e) (118+/-30)x10 super(-) super(1) super(2)cm super(3)molecule super(-) super(1)s super(-) super(1) and k sub(O) sub(3) sub(+) sub( beta ) sub( approximately equal to ) sub(i) sub(o) sub(n) sub(o) sub(n) sub(e), (0.19+ /-0.05)x10 super(-) super(1) super(6)cm super(3)molecule super(-) super(1)s super(-) super(1), were measured using the relative rate technique for the reaction of the hydroxyl radical (OH) and ozone (O sub(3)) with 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one ( beta -ionone) at 297+/-3K and 1atm total pressure. To more clearly define part of beta -ionone's indoor environment degradation mechanism, the products of the beta -ionone+OH? and beta -ionone+O sub(3) reactions were also investigated. The identified beta -ionone+OH? reaction products were: glyoxal (ethanedial, HC(=O)C(=O)H), and methylglyoxal (2-oxopropanal, CH sub(3)C(=O)C(=O)H) and the identified beta -ionone+O sub(3) reaction product was 2-oxopropanal. The derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) were used to propose 2,6,6-trimethylcyclohex-1-ene-1-carbaldehyde as the other major beta -ionone+OH? and beta -ionone+O sub(3) reaction product. The elucidation of this other reaction product was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible beta -ionone+OH? and beta -ionone+O sub(3) reaction mechanisms based on previously published volatile organic compound+OH? and volatile organic compound+O sub(3) gas-phase reaction mechanisms. The additional gas-phase products observed from the beta -ionone+OH? reaction are proposed to be the result of cyclization through a radical intermediate. JF - Atmospheric Environment AU - Forester, C D AU - Ham, JE AU - Wells, J R AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, ozw0@cdc.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 8758 EP - 8771 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 41 IS - 38 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Ozone measurements KW - Mass spectrometry KW - Hydroxyl radicals KW - Hydroxyl photochemistry KW - Indoor environments KW - Ozone KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20692308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=beta+-Ionone+reactions+with+ozone+and+OH+radical%3A+Rate+constants+and+gas-phase+products&rft.au=Forester%2C+C+D%3BHam%2C+JE%3BWells%2C+J+R&rft.aulast=Forester&rft.aufirst=C&rft.date=2007-12-01&rft.volume=41&rft.issue=38&rft.spage=8758&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2007.07.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Ozone measurements; Mass spectrometry; Hydroxyl photochemistry; Ozone; Indoor environments; Hydroxyl radicals DO - http://dx.doi.org/10.1016/j.atmosenv.2007.07.047 ER - TY - JOUR T1 - Overview of monoclonal B-cell lymphocytosis AN - 20588748; 7978368 AB - Monoclonal B-cell lymphocytosis (MBL) has been the subject of more intensive investigation for the last 10 years. The increased presence of MBL in unaffected, first-degree relatives with familial chronic lymphocytic leukaemia (CLL) suggest that it is surrogate marker for early disease. In normal population studies, MBL is found to be increased in ageing subjects. Consensus criteria for the diagnosis of MBL have been proposed. The differential diagnosis has been further clarified and the prevalence of MBL is most prominent in the elderly. The aetiology of MBL is unknown but probably involves immune mechanism of senescence or altered response. Environmental health studies suggest that exposure to certain toxins may lead to MBL but further work is needed. MBL is a precursor to CLL but may also regress, remain stable or progress to clinical CLL. JF - British Journal of Haematology AU - Marti, Gerald AU - Abbasi, Fatima AU - Raveche, Elizabeth AU - Rawstron, Andy C AU - Ghia, Paolo AU - Aurran, Therese AU - Caporaso, Neil AU - Shim, Youn K AU - Vogt, Robert F AD - Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), NIH, Bethesda, MD, gemarti@helix.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 701 EP - 708 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 139 IS - 5 SN - 0007-1048, 0007-1048 KW - Health & Safety Science Abstracts; Immunology Abstracts KW - chronic lymphocytic leukaemia KW - monoclonal B-cell lymphocytosis KW - Lymphocytes B KW - Aging KW - Environmental health KW - Population studies KW - Toxins KW - population studies KW - Leukemia KW - Lymphocytosis KW - Differential diagnosis KW - Reviews KW - senescence KW - Geriatrics KW - Senescence KW - elderly KW - Chronic lymphatic leukemia KW - F 06915:Cancer Immunology KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Haematology&rft.atitle=Overview+of+monoclonal+B-cell+lymphocytosis&rft.au=Marti%2C+Gerald%3BAbbasi%2C+Fatima%3BRaveche%2C+Elizabeth%3BRawstron%2C+Andy+C%3BGhia%2C+Paolo%3BAurran%2C+Therese%3BCaporaso%2C+Neil%3BShim%2C+Youn+K%3BVogt%2C+Robert+F&rft.aulast=Marti&rft.aufirst=Gerald&rft.date=2007-12-01&rft.volume=139&rft.issue=5&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Haematology&rft.issn=00071048&rft_id=info:doi/10.1111%2Fj.1365-2141.2007.06865.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Differential diagnosis; Lymphocytosis; Lymphocytes B; Reviews; Aging; Geriatrics; Population studies; Senescence; Chronic lymphatic leukemia; Toxins; population studies; Leukemia; senescence; Environmental health; elderly DO - http://dx.doi.org/10.1111/j.1365-2141.2007.06865.x ER - TY - JOUR T1 - Gastroenteritis Outbreak Caused by Waterborne Norovirus at a New Zealand Ski Resort AN - 20552086; 7932127 AB - In July 2006, public health services investigated an outbreak of acute gastroenteritis among staff and visitors of a popular ski resort in southern New Zealand. The source of the outbreak was a drinking water supply contaminated by human sewage. The virological component of the investigation played a major role in confirming the source of the outbreak. Drinking water, source stream water, and 31 fecal specimens from gastroenteritis outbreak cases were analyzed for the presence of norovirus (NoV). Water samples were concentrated by ultrafiltration, and real-time reverse transcription-PCR (RT-PCR) was used for rapid detection of NoV from both water and fecal samples. The implicated NoV strain was further characterized by DNA sequencing. NoV genogroup GI/5 was identified in water samples and linked case fecal specimens, providing clear evidence of the predominant pathogen and route of exposure. A retrospective cohort study demonstrated that staff who consumed drinking water from the resort supply were twice as likely to have gastroenteritis than those who did not. This is the first time that an outbreak of gastroenteritis in New Zealand has been conclusively linked to NoV detected in a community water supply. To our knowledge, this is the first report of the use of ultrafiltration combined with quantitative real-time RT-PCR and DNA sequencing for investigation of a waterborne NoV outbreak. JF - Applied and Environmental Microbiology AU - Hewitt, Joanne AU - Bell, Derek AU - Simmons, Greg C AU - Rivera-Aban, Malet AU - Wolf, Sandro AU - Greening, Gail E AD - Communicable Disease Group, Institute of Environmental Science & Research Ltd., Kenepuru Science Centre, P.O. Box 50-348, Porirua, New Zealand. Public Health South, P.O. Box 2180, Queenstown, New Zealand. Auckland Regional Public Health Service, Private Bag 92605, Auckland, New Zealand Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 7853 EP - 7857 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 24 SN - 0099-2240, 0099-2240 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Ultrafiltration KW - Norovirus KW - Pathogens KW - Streams KW - Water supplies KW - Ski protein KW - Public health KW - DNA sequencing KW - Sewage KW - Polymerase chain reaction KW - Gastroenteritis KW - Drinking water KW - V 22490:Miscellaneous KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20552086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Gastroenteritis+Outbreak+Caused+by+Waterborne+Norovirus+at+a+New+Zealand+Ski+Resort&rft.au=Hewitt%2C+Joanne%3BBell%2C+Derek%3BSimmons%2C+Greg+C%3BRivera-Aban%2C+Malet%3BWolf%2C+Sandro%3BGreening%2C+Gail+E&rft.aulast=Hewitt&rft.aufirst=Joanne&rft.date=2007-12-01&rft.volume=73&rft.issue=24&rft.spage=7853&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ultrafiltration; DNA sequencing; Sewage; Polymerase chain reaction; Pathogens; Drinking water; Gastroenteritis; Water supplies; Streams; Public health; Ski protein; Norovirus ER - TY - JOUR T1 - Anaerobic Metabolism of 1-Amino-2-Naphthol-Based Azo Dyes (Sudan Dyes) by Human Intestinal Microflora AN - 20550202; 7928276 AB - The rates of metabolism of Sudan I and II and Para Red by human intestinal microflora were high compared to those of Sudan III and IV under anaerobic conditions. Metabolites of the dyes were identified as aniline, 2,4-dimethylaniline, o-toluidine, and 4-nitroaniline through high-performance liquid chromatography and liquid chromatography electrospray ionization tandem mass spectrometry analyses. These data indicate that human intestinal bacteria are able to reduce Sudan dyes to form potentially carcinogenic aromatic amines. JF - Applied and Environmental Microbiology AU - Xu, Haiyan AU - Heinze, Thomas M AU - Chen, Siwei AU - Cerniglia, Carl E AU - Chen, Huizhong AD - Division of Microbiology. Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079-9502 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7759 EP - 7762 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 23 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - High-performance liquid chromatography KW - Data processing KW - Azo dyes KW - o-toluidine KW - Metabolites KW - Anaerobic conditions KW - Mass spectroscopy KW - Intestinal microflora KW - amines KW - Dyes KW - Liquid chromatography KW - Intestine KW - Aromatics KW - Aniline KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20550202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Anaerobic+Metabolism+of+1-Amino-2-Naphthol-Based+Azo+Dyes+%28Sudan+Dyes%29+by+Human+Intestinal+Microflora&rft.au=Xu%2C+Haiyan%3BHeinze%2C+Thomas+M%3BChen%2C+Siwei%3BCerniglia%2C+Carl+E%3BChen%2C+Huizhong&rft.aulast=Xu&rft.aufirst=Haiyan&rft.date=2007-12-01&rft.volume=73&rft.issue=23&rft.spage=7759&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Data processing; Azo dyes; o-toluidine; Metabolites; Anaerobic conditions; Mass spectroscopy; Intestinal microflora; amines; Dyes; Liquid chromatography; Intestine; Aromatics; Aniline ER - TY - JOUR T1 - Serious Psychological Distress Among Parenting and Nonparenting Adults AN - 20522255; 7928565 AB - OBJECTIVES: We compared the prevalence of serious psychological distress among parenting adults with the prevalence among nonparenting adults and the sociodemographic correlates of serious psychological distress between these 2 populations. METHODS: We drew data from 14240 parenting adults and 19224 nonparenting adults who responded to the 2002 National Survey on Drug Use and Health. We used logistic regression procedures in our analysis. RESULTS: An estimated 8.9% of parenting adults had serious psychological distress in the prior year compared with 12.0% of nonparenting adults of similar age. In both groups, the adjusted odds of having serious psychological distress were higher among adults who were women, younger (between the ages of 18 and 44 years), low income, or receiving Medicaid. We found some differences in the correlates of serious psychological distress between parenting adults and nonparenting adults. The odds of having serious psychological distress were lower among parenting adults after we controlled for demographic characteristics. CONCLUSIONS: Serious psychological distress is fairly prevalent among parenting adults, and high-risk sociodemographic groups of parenting adults should be targeted to ensure access to coordination of services. JF - American Journal of Public Health AU - Herman-Stahl, Mindy AU - Ashley, Olivia Silber AU - Penne, Michael A AU - Bauman, Karl E AU - Weitzenkamp, David AU - Aldridge, Molly AU - Gfroerer, Joseph C AD - Mindy Herman-Stahl, Olivia Silber Ashley, Michael A. Penne, Karl E. Bauman, and David Weitzenkamp are with RTI International, Research Triangle Park, NC. At the time of the study, Molly Aldridge was with RTI International, Research Triangle Park, NC. Joseph C. Gfroerer is with the Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, Md Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2222 EP - 2229 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 12 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20522255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Serious+Psychological+Distress+Among+Parenting+and+Nonparenting+Adults&rft.au=Herman-Stahl%2C+Mindy%3BAshley%2C+Olivia+Silber%3BPenne%2C+Michael+A%3BBauman%2C+Karl+E%3BWeitzenkamp%2C+David%3BAldridge%2C+Molly%3BGfroerer%2C+Joseph+C&rft.aulast=Herman-Stahl&rft.aufirst=Mindy&rft.date=2007-12-01&rft.volume=97&rft.issue=12&rft.spage=2222&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Association of Smoking Cessation With Financial Stress and Material Well-Being: Results From a Prospective Study of a Population-Based National Survey AN - 20521906; 7928573 AB - OBJECTIVES: We used 4 waves of prospective data to examine the association of smoking cessation with financial stress and material well-being. METHODS: Data (n = 5699 at baseline) came from 4 consecutive waves (2001-2005) of the Household Income and Labour Dynamics in Australia survey. We used mixed models to examine the participant-specific association of smoking cessation with financial stress and material well-being. RESULTS: On average, a smoker who quits is expected to have a 25% reduction (P<.001; odds ratio [OR]=0.75; 95% confidence interaval [CI]=0.69, 0.81) in the odds of financial stress. Similarly, the data provided strong evidence (P<.001) that a smoker who quits is likely to experience an enhanced level of material well-being. CONCLUSIONS: Our findings indicate that interventions to encourage smoking cessation are likely to improve standards of living and reduce deprivation. The findings provide grounds for encouraging the social services sector to incorporate smoking cessation efforts into their programs to enhance the material or financial conditions of disadvantaged groups. The findings also provide additional incentives for smokers to stop smoking and as such can be used in antismoking campaigns and by smoking cessation services. JF - American Journal of Public Health AU - Siahpush, Mohammad AU - Spittal, Matt AU - Singh, Gopal K AD - At the time of this study, Mohammad Siahpush and Matt Spittal were with the Centre for Behavioural Research in Cancer, Cancer Council Victoria, Victoria, Australia. Gopal K. Singh is with the Maternal and Child Health Bureau, Health Resources and Service Administration, Rockville, Md Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2281 EP - 2287 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 12 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20521906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Association+of+Smoking+Cessation+With+Financial+Stress+and+Material+Well-Being%3A+Results+From+a+Prospective+Study+of+a+Population-Based+National+Survey&rft.au=Siahpush%2C+Mohammad%3BSpittal%2C+Matt%3BSingh%2C+Gopal+K&rft.aulast=Siahpush&rft.aufirst=Mohammad&rft.date=2007-12-01&rft.volume=97&rft.issue=12&rft.spage=2281&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance-linked ATP binding cassette drug transporter ABCG2 AN - 20472676; 7936730 AB - Vitamin K3 (menadione; 2-methyl-1,4-naphthoquinone) is a structural precursor of vitamins K1 and K2, which are essential for blood clotting. The naturally occurring structural analogue of this vitamin, plumbagin (5-hydroxy-menadione), is known to modulate cellular proliferation, apoptosis, carcinogenesis, and radioresistance. We here report that both vitamin K3 and plumbagin are substrates of the multidrug resistance-linked ATP binding cassette drug transporter, ABCG2. Vitamin K3 and plumbagin specifically inhibited the ABCG2-mediated efflux of mitoxantrone but did not have any effect on the ABCB1-mediated efflux of rhodamine 123. This inhibition of ABCG2 function was due to their interaction at the substrate-binding site(s). Vitamin K3 and plumbagin inhibited the binding of [ super(125)I]iodoarylazidoprazosin, a substrate of ABCG2, to this transporter in a concentration-dependent manner with IC sub(50) values of 7.3 and 22.6 mu mol/L, respectively, but had no effect on the binding of the photoaffinity analogue to ABCB1. Both compounds stimulated ABCG2-mediated ATP hydrolysis and also inhibited the mitoxantrone-stimulated ATPase activity of the ABCG2 transporter, but did not have any significant effect on the ATPase activity of ABCB1. In a cytotoxicity assay, ABCG2-expressing HEK cells were 2.8- and 2.3-fold resistant to plumbagin and vitamin K3, respectively, compared with the control cells, suggesting that they are substrates of this transporter. Collectively, these data show for the first time that vitamin K3 is a substrate of the ABCG2 transporter. Thus, ABCG2 may have a role in the regulation of vitamin K3 levels in the body. In addition, vitamin K3 and its structural derivative, plumbagin, could potentially be used to modulate ABCG2 function. [Mol Cancer Ther 2007; 6(12):3279-86] JF - Molecular Cancer Therapeutics AU - Shukla, Suneet AU - Wu, Chung-Pu AU - Nandigama, Krishnamachary AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3279 EP - 3286 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 12 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Adenosinetriphosphatase KW - Apoptosis KW - ATP KW - Hydrolysis KW - Cancer KW - Blood coagulation KW - Stem cells KW - Cytotoxicity KW - Vitamins KW - Carcinogenesis KW - Menadione KW - Hemopoiesis KW - Plumbagin KW - Radioresistance KW - rhodamine KW - mitoxantrone KW - Drugs KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20472676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=The+naphthoquinones%2C+vitamin+K3+and+its+structural+analogue+plumbagin%2C+are+substrates+of+the+multidrug+resistance-linked+ATP+binding+cassette+drug+transporter+ABCG2&rft.au=Shukla%2C+Suneet%3BWu%2C+Chung-Pu%3BNandigama%2C+Krishnamachary%3BAmbudkar%2C+Suresh+V&rft.aulast=Shukla&rft.aufirst=Suneet&rft.date=2007-12-01&rft.volume=6&rft.issue=12&rft.spage=3279&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Apoptosis; Adenosinetriphosphatase; ATP; Hydrolysis; Cancer; Cytotoxicity; Stem cells; Blood coagulation; Vitamins; Carcinogenesis; Menadione; Plumbagin; Hemopoiesis; Radioresistance; Drugs; mitoxantrone; rhodamine ER - TY - JOUR T1 - Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models AN - 20427212; 7938622 AB - This report presents a comparison of the predictive performance of MC4PC and MDL-QSAR software as well as a method for combining the predictions from both programs to increase overall accuracy. The conclusions are based on 10x10% leave-many-out internal cross-validation studies using 1540 training set compounds with 2-year rodent carcinogenicity findings. The models were generated using the same weight of evidence scoring method previously developed [Matthews, E.J., Contrera, J.F., 1998. A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software. Regul. Toxicol. Pharmacol. 28, 242-264.]. Although MC4PC and MDL-QSAR use different algorithms, their overall predictive performance was remarkably similar. Respectively, the sensitivity of MC4PC and MDL-QSAR was 61 and 63%, specificity was 71 and 75%, and concordance was 66 and 69%. Coverage for both programs was over 95% and receiver operator characteristic (ROC) intercept statistic values were above 2.00. The software programs had complimentary coverage with none of the 1540 compounds being uncovered by both MC4PC and MDL-QSAR. Merging MC4PC and MDL-QSAR predictions improved the overall predictive performance. Consensus sensitivity increased to 67%, specificity to 84%, concordance to 76%, and ROC to 4.31. Consensus rules can be tuned to reflect the priorities of the user, so that greater emphasis may be placed on predictions with high sensitivity/low false negative rates or high specificity/low false positive rates. Sensitivity was optimized to 75% by reclassifying all compounds predicted to be positive in MC4PC or MDL-QSAR as positive, and specificity was optimized to 89% by reclassifying all compounds predicted negative in MC4PC or MDL-QSAR as negative. JF - Regulatory Toxicology and Pharmacology AU - Contrera, J F AU - Kruhlak, N L AU - Matthews, E J AU - Benz, R D AD - Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff, Mail Drop 1603, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA, Joseph.Contrera@fda.hhs.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 172 EP - 182 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 49 IS - 3 SN - 0273-2300, 0273-2300 KW - Toxicology Abstracts KW - Computer programs KW - software KW - Carcinogenicity KW - Algorithms KW - Pharmaceuticals KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20427212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Comparison+of+MC4PC+and+MDL-QSAR+rodent+carcinogenicity+predictions+and+the+enhancement+of+predictive+performance+by+combining+QSAR+models&rft.au=Contrera%2C+J+F%3BKruhlak%2C+N+L%3BMatthews%2C+E+J%3BBenz%2C+R+D&rft.aulast=Contrera&rft.aufirst=J&rft.date=2007-12-01&rft.volume=49&rft.issue=3&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2007.07.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Carcinogenicity; Algorithms; Pharmaceuticals DO - http://dx.doi.org/10.1016/j.yrtph.2007.07.001 ER - TY - JOUR T1 - Assessment of Child and Adolescent Overweight and Obesity AN - 20375804; 7745308 AB - Accurate appropriate assessment of overweight and obesity in children and adolescents is a critical aspect of contemporary medical care. However, physicians and other health care professionals may find this a somewhat thorny field to enter. The BMI has become the standard as a reliable indicator of overweight and obesity. The BMI is incomplete, however, without consideration of the complex behavioral factors that influence obesity.Because of limited time and resources, clinicians need to have quick, evidence-based interventions that can help patients and their families recognize the importance of reducing overweight and obesity and take action. In an era of fast food, computers, and DVDs, it is not easy to persuade patients to modify their diets and to become more physically active. Because research concerning effective assessment of childhood obesity contains many gaps, this report is intended to provide a comprehensive approach to assessment and to present the evidence available to support key aspects of assessment. The discussion and recommendations are based on >300 studies published since 1995, which examined an array of assessment tools. With this information, clinicians should find themselves better equipped to face the challenges of assessing childhood overweight and obesity accurately. JF - Pediatrics AU - Krebs, Nancy F AU - Himes, John H AU - Jacobson, Dawn AU - Nicklas, Theresa A AU - Guilday, Patricia AU - Styne, Dennis AD - Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota. Office of Disease Prevention and Health Promotion, Department of Health and Human Services, Rockville, Maryland. Department of Pediatrics, Baylor College of Medicine, Houston, Texas. PS duPont Elementary School, Wilmington, Delaware. Department of Pediatrics, University of California, Davis, Sacramento, California Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - S193 EP - S228 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 120 SN - 0031-4005, 0031-4005 KW - Physical Education Index KW - Obesity KW - Health (care) KW - Diet (effects) KW - Pediatrics KW - Adolescence KW - Body mass KW - Computers KW - Patients KW - Children KW - Evaluation KW - Family KW - Physicians KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20375804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Assessment+of+Child+and+Adolescent+Overweight+and+Obesity&rft.au=Krebs%2C+Nancy+F%3BHimes%2C+John+H%3BJacobson%2C+Dawn%3BNicklas%2C+Theresa+A%3BGuilday%2C+Patricia%3BStyne%2C+Dennis&rft.aulast=Krebs&rft.aufirst=Nancy&rft.date=2007-12-01&rft.volume=120&rft.issue=&rft.spage=S193&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Evaluation; Obesity; Diet (effects); Health (care); Pediatrics; Computers; Body mass; Adolescence; Family; Physicians; Patients; Children ER - TY - JOUR T1 - AUC/MIC: a PK/PD index for antibiotics with a time dimension or simply a dimensionless scoring factor? AN - 20373139; 7741463 AB - A previous article on standardization of pharmacokinetic/pharmacodynamic terminology for anti-infective drugs recommended deletion of the units of the AUC/MIC ratio (actually h). We express here the difficulties presented by this proposal and we propose expressing AUC/MIC as a scaling factor corresponding to the current index divided now by 24 h. This is the scaling factor without units by which the targeted MIC should be multiplied to estimate the average in vivo plasma concentration to be achieved. Associated with this proposal, we address the specific issue of veterinary drug products for which steady conditions are seldom achieved. To accommodate the need for dose prediction during these novel therapeutic situations, we propose a general approach that is based on the targeted time interval over which some desired average concentration should be maintained. JF - Journal of Antimicrobial Chemotherapy AU - Toutain, Pierre-Louis AU - Bousquet-Melou, Alain AU - Martinez, Marilyn AD - UMR181 Physiopathologie et Toxicologie Experimentales INRA, ENVT, 23 Chemin des Capelles, 31076 Toulouse cedex 03, France. FDA, Center for Veterinary Medicine, Rockville, MD, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1185 EP - 1188 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 60 IS - 6 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Standardization KW - Antibiotics KW - Minimum inhibitory concentration KW - Drugs KW - Pharmacokinetics KW - Pharmacodynamics KW - A 01350:Microbial Resistance KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=AUC%2FMIC%3A+a+PK%2FPD+index+for+antibiotics+with+a+time+dimension+or+simply+a+dimensionless+scoring+factor%3F&rft.au=Toutain%2C+Pierre-Louis%3BBousquet-Melou%2C+Alain%3BMartinez%2C+Marilyn&rft.aulast=Toutain&rft.aufirst=Pierre-Louis&rft.date=2007-12-01&rft.volume=60&rft.issue=6&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Standardization; Antibiotics; Drugs; Minimum inhibitory concentration; Pharmacodynamics; Pharmacokinetics ER - TY - JOUR T1 - Differential Requirements by CD4 super(+) and CD8 super(+) T Cells for Soluble and Membrane TNF in Control of Francisella tularensis Live Vaccine Strain Intramacrophage Growth AN - 20324339; 7743272 AB - During primary infection with intracellular bacteria, the membrane-associated form of TNF provides some TNF functions, but the relative contributions during memory responses are not well-characterized. In this study, we determined the role of T cell-derived secreted and membrane-bound TNF (memTNF) during adaptive immunity to Francisella tularensis live vaccine strain (LVS). Although transgenic mice expressing only the memTNF were more susceptible to primary LVS infection than wild-type (WT) mice, LVS-immune WT and memTNF mice both survived maximal lethal secondary Francisella challenge. Generation of CD44 super(high) memory T cells and clearance of bacteria were similar, although more IFN- gamma and IL-12(p40) were produced by memTNF mice. To examine T cell function, we used an in vitro tissue coculture system that measures control of LVS intramacrophage growth by LVS-immune WT and memTNF-T cells. LVS-immune CD4 super(+) and CD8 super(+) T cells isolated from WT and memTNF mice exhibited comparable control of LVS growth in either normal or TNF- alpha knockout macrophages. Although the magnitude of CD4 super(+) T cell-induced macrophage NO production clearly depended on TNF, control of LVS growth by both CD4 super(+) and CD8 super(+) T cells did not correlate with levels of nitrite. Importantly, intramacrophage LVS growth control by CD8 super(+) T cells, but not CD4 super(+) T cells, was almost entirely dependent on T cell-expressed TNF, and required stimulation through macrophage TNFRs. Collectively, these data demonstrate that T cell-expressed memTNF is necessary and sufficient for memory T cell responses to this intracellular pathogen, and is particularly important for intramacrophage control of bacterial growth by CD8 super(+) T cells. JF - Journal of Immunology AU - Cowley, Siobhan C AU - Sedgwick, Jonathon D AU - Elkins, Karen L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, U.S. Food and Drug Administration, Rockville, MD 20852. Eli Lilly and Company, Indianapolis, IN 46285 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7709 EP - 7719 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 11 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - gamma -Interferon KW - Memory cells KW - Immunological memory KW - Francisella tularensis KW - Pathogens KW - CD8 antigen KW - Transgenic mice KW - Infection KW - Tumor necrosis factor receptors KW - CD4 antigen KW - Lymphocytes T KW - Nitric oxide KW - Tumor necrosis factor- alpha KW - Vaccines KW - Nitrite KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20324339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Differential+Requirements+by+CD4+super%28%2B%29+and+CD8+super%28%2B%29+T+Cells+for+Soluble+and+Membrane+TNF+in+Control+of+Francisella+tularensis+Live+Vaccine+Strain+Intramacrophage+Growth&rft.au=Cowley%2C+Siobhan+C%3BSedgwick%2C+Jonathon+D%3BElkins%2C+Karen+L&rft.aulast=Cowley&rft.aufirst=Siobhan&rft.date=2007-12-01&rft.volume=179&rft.issue=11&rft.spage=7709&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; gamma -Interferon; Immunological memory; Memory cells; CD8 antigen; Pathogens; Infection; Transgenic mice; Tumor necrosis factor receptors; CD4 antigen; Lymphocytes T; Nitric oxide; Vaccines; Tumor necrosis factor- alpha; Nitrite; Francisella tularensis ER - TY - JOUR T1 - ANTIMICROBIAL SUSCEPTIBILITY AND DISTRIBUTION OF ANTIMICROBIAL-RESISTANCE GENES AMONG ENTEROCOCCUS AND COAGULASE-NEGATIVE STAPHYLOCOCCUS ISOLATES RECOVERED FROM POULTRY LITTER AN - 20216882; 8698549 JF - Avian Diseases Digest AU - Simjee, Shabbir AU - McDermott, Patrick F AU - White, David G AU - Hofacre, Charles AU - Berghaus, Roy D AU - Carter, Peggy J AU - Stewart, Leigh AU - LIU, TONGRUI AU - Maier, Marie AU - Maurer, John J AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, MD 20708 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - e23 PB - American Association of Avian Pathologists VL - 2 IS - 4 SN - 1933-5334, 1933-5334 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Litter KW - Poultry KW - Enterococcus KW - Staphylococcus KW - Antimicrobial agents KW - J 02410:Animal Diseases KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20216882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Avian+Diseases+Digest&rft.atitle=ANTIMICROBIAL+SUSCEPTIBILITY+AND+DISTRIBUTION+OF+ANTIMICROBIAL-RESISTANCE+GENES+AMONG+ENTEROCOCCUS+AND+COAGULASE-NEGATIVE+STAPHYLOCOCCUS+ISOLATES+RECOVERED+FROM+POULTRY+LITTER&rft.au=Simjee%2C+Shabbir%3BMcDermott%2C+Patrick+F%3BWhite%2C+David+G%3BHofacre%2C+Charles%3BBerghaus%2C+Roy+D%3BCarter%2C+Peggy+J%3BStewart%2C+Leigh%3BLIU%2C+TONGRUI%3BMaier%2C+Marie%3BMaurer%2C+John+J&rft.aulast=Simjee&rft.aufirst=Shabbir&rft.date=2007-12-01&rft.volume=2&rft.issue=4&rft.spage=e23&rft.isbn=&rft.btitle=&rft.title=Avian+Diseases+Digest&rft.issn=19335334&rft_id=info:doi/10.1637%2F1933-5334%282007%2922.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Staphylococcus; Enterococcus; Poultry; Antimicrobial agents; Litter DO - http://dx.doi.org/10.1637/1933-5334(2007)2[e23:ASADOA]2.0.CO;2 ER - TY - JOUR T1 - Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes III. An Efficient Method of Monitoring Chromosomal Damage in the Beagle Dog AN - 20046077; 7746661 AB - Erythrocyte-based micronucleus tests have traditionally analyzed bone marrow because splenic filtration in most species removes micronucleated cells from peripheral blood. We have evaluated a flow cytometric method for monitoring micronucleated reticulocyte frequencies (%MN-RET) in the peripheral blood of beagle dogs treated with cyclophosphamide (CP) and have found that analysis of micronucleated reticulocytes (MN-RETs) in peripheral blood is a suitable surrogate for bone marrow analysis. The three-color flow cytometric method uses anti-CD71 labeling to identify reticulocytes and Plasmodium berghei-containing erythrocytes as a calibration standard. The spontaneous %MN-RET determined by flow cytometry was 0.31 plus or minus 0.09% (n = 22) for peripheral blood, compared with 0.38 plus or minus 0.13% (SD, n = 12) for bone marrow, and 0.27 plus or minus 0.08% (n = 12) for peripheral blood by microscopic scoring with acridine orange staining. The kinetics of appearance and disappearance of MN-RETs in blood were determined by collecting daily samples after iv treatment with CP. The maximum frequency occurred similar to 48 h after dosing. Frequencies of MN-RETs in peripheral blood at steady state following daily CP treatment were 55-68% of corresponding bone marrow values assessed by microscopy and 55-112% as assessed by flow cytometry. This difference is presumably due to splenic removal, which appears slightly less stringent than that previously reported for CP-treated Sprague-Dawley rats. Responses in bone marrow and peripheral blood were highly correlated and similar to or greater than those reported in mice and rats at equitoxic doses. JF - Toxicological Sciences AU - Harper, Susan B AU - Dertinger, Stephen D AU - Bishop, Michelle E AU - Lynch, Anthony M AU - Lorenzo, Maria AU - Saylor, Michelle AU - MacGregor, James T AD - Department of Veterans Affairs, Washington, DC 20422. Litron Laboratories, Rochester, NY 14623. National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079. GlaxoSmithKline Research & Development, Herts, SG12 0DP, UK. U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Laurel, MD 20708. Toxicology Consulting Services, Arnold, MD 21012 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 406 EP - 414 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 100 IS - 2 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - Acridine orange KW - Micronuclei KW - Erythrocytes KW - Bone marrow KW - Spleen KW - Peripheral blood KW - Cyclophosphamide KW - Flow cytometry KW - Plasmodium KW - Filtration KW - Kinetics KW - Microscopy KW - Reticulocytes KW - K 03410:Animal Diseases KW - G 07870:Mammals KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20046077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Flow+Cytometric+Analysis+of+Micronuclei+in+Peripheral+Blood+Reticulocytes+III.+An+Efficient+Method+of+Monitoring+Chromosomal+Damage+in+the+Beagle+Dog&rft.au=Harper%2C+Susan+B%3BDertinger%2C+Stephen+D%3BBishop%2C+Michelle+E%3BLynch%2C+Anthony+M%3BLorenzo%2C+Maria%3BSaylor%2C+Michelle%3BMacGregor%2C+James+T&rft.aulast=Harper&rft.aufirst=Susan&rft.date=2007-12-01&rft.volume=100&rft.issue=2&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Acridine orange; Flow cytometry; Filtration; Kinetics; Microscopy; Erythrocytes; Micronuclei; Bone marrow; Spleen; Peripheral blood; Cyclophosphamide; Reticulocytes; Plasmodium ER - TY - JOUR T1 - Variability of Total and Pathogenic Vibrio parahaemolyticus Densities in Northern Gulf of Mexico Water and Oysters AN - 19993264; 7928254 AB - Vibrio parahaemolyticus is indigenous to coastal environments and a frequent cause of seafood-borne gastroenteritis in the United States, primarily due to raw-oyster consumption. Previous seasonal-cycle studies of V. parahaemolyticus have identified water temperature as the strongest environmental predictor. Salinity has also been identified, although it is evident that its effect on annual variation is not as pronounced. The effects of other environmental factors, both with respect to the seasonal cycle and intraseasonal variation, are uncertain. This study investigated intraseasonal variations of densities of total and pathogenic V. parahaemolyticus organisms in oysters and overlying waters during the summer of 2004 at two sites in the northern Gulf of Mexico. Regression analyses indicated significant associations (P < 0.001) between total V. parahaemolyticus densities and salinity, as well as turbidity in water and in oysters at the Mississippi site but not at the Alabama site. Pathogenic V. parahaemolyticus organisms in Mississippi oyster and water samples were detected in 56% (9 out of 16) and 78% (43 out of 55) of samples, respectively. In contrast, 44% (7 out of 16) of oyster samples and 30% (14 out of 47) of water samples from Alabama were positive. At both sites, there was greater sample-to-sample variability in pathogenic V. parahaemolyticus densities than in total V. parahaemolyticus densities. These data suggest that, although total V. parahaemolyticus densities may be very informative, there is greater uncertainty when total V. parahaemolyticus densities are used to predict the risk of infection by pathogenic V. parahaemolyticus than previously recognized. JF - Applied and Environmental Microbiology AU - Zimmerman, A M AU - DePaola, A AU - Bowers, J C AU - Krantz, JA AU - Nordstrom, J L AU - Johnson, C N AU - Grimes, D J AD - University of Southern Mississippi, Gulf Coast Research Laboratory, Ocean Springs, Mississippi. Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama. Food and Drug Administration, College Park, Maryland Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7589 EP - 7596 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 73 IS - 23 SN - 0099-2240, 0099-2240 KW - Ecology Abstracts; Aqualine Abstracts; Pollution Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts A: Industrial & Applied Microbiology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - ASW, USA, Alabama KW - Coastal environments KW - Water Sampling KW - Gulfs KW - Public health KW - Salinity KW - Vibrio parahaemolyticus KW - Seasonal variations KW - environmental factors KW - annual variations KW - Pathogenic bacteria KW - Water temperature KW - Vibrio KW - Coastal zone KW - Oysters KW - Marine molluscs KW - Turbidity KW - Variability KW - Geographical distribution KW - Water sampling KW - Water Analysis KW - Infection KW - Environmental factors KW - Sulfur dioxide KW - oysters KW - Salinity effects KW - infection KW - Regression analysis KW - Marine KW - Data processing KW - Annual variations KW - Density KW - ASW, Mexico Gulf KW - ASW, USA, Mississippi KW - gastroenteritis KW - Water wells KW - summer KW - Gastroenteritis KW - water temperature KW - AQ 00001:Water Resources and Supplies KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - SW 0810:General KW - A 01450:Environmental Pollution & Waste Treatment KW - D 04040:Ecosystem and Ecology Studies KW - P 1000:MARINE POLLUTION KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19993264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Variability+of+Total+and+Pathogenic+Vibrio+parahaemolyticus+Densities+in+Northern+Gulf+of+Mexico+Water+and+Oysters&rft.au=Zimmerman%2C+A+M%3BDePaola%2C+A%3BBowers%2C+J+C%3BKrantz%2C+JA%3BNordstrom%2C+J+L%3BJohnson%2C+C+N%3BGrimes%2C+D+J&rft.aulast=Zimmerman&rft.aufirst=A&rft.date=2007-12-01&rft.volume=73&rft.issue=23&rft.spage=7589&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Coastal zone; Geographical distribution; Pathogenic bacteria; Annual variations; Marine molluscs; Seasonal variations; Turbidity; Public health; Data processing; Coastal environments; Salinity effects; Regression analysis; Water temperature; Gastroenteritis; Infection; Environmental factors; environmental factors; Water sampling; annual variations; Salinity; oysters; Sulfur dioxide; gastroenteritis; infection; summer; Water wells; water temperature; Variability; Vibrio; Water Analysis; Oysters; Density; Water Sampling; Gulfs; Vibrio parahaemolyticus; ASW, Mexico Gulf; ASW, USA, Mississippi; ASW, USA, Alabama; Marine ER - TY - JOUR T1 - Genome Sequence Analysis of the Emerging Human Pathogenic Acetic Acid Bacterium Granulibacter bethesdensis AN - 19900078; 7741959 AB - Chronic granulomatous disease (CGD) is an inherited immune deficiency characterized by increased susceptibility to infection with Staphylococcus, certain gram-negative bacteria, and fungi. Granulibacter bethesdensis, a newly described genus and species within the family Acetobacteraceae, was recently isolated from four CGD patients residing in geographically distinct locales who presented with fever and lymphadenitis. We sequenced the genome of the reference strain of Granulibacter bethesdensis, which was isolated from lymph nodes of the original patient. The genome contains 2,708,355 base pairs in a single circular chromosome, in which 2,437 putative open reading frames (ORFs) were identified, 1,470 of which share sequence similarity with ORFs in the nonpathogenic but related Gluconobacter oxydans genome. Included in the 967 ORFs that are unique to G. bethesdensis are ORFs potentially important for virulence, adherence, DNA uptake, and methanol utilization. GC% values and best BLAST analysis suggested that some of these unique ORFs were recently acquired. Comparison of G. bethesdensis to other known CGD pathogens demonstrated conservation of some putative virulence factors, suggesting possible common mechanisms involved in pathogenesis in CGD. Genotyping of the four patient isolates by use of a custom microarray demonstrated genome-wide variations in regions encoding DNA uptake systems and transcriptional regulators and in hypothetical ORFs. G. bethesdensis is a genetically diverse emerging human pathogen that may have recently acquired virulence factors new to this family of organisms. JF - Journal of Bacteriology AU - Greenberg, David E AU - Porcella, Stephen F AU - Zelazny, Adrian M AU - Virtaneva, Kimmo AU - Sturdevant, Dan E AU - Kupko, John JIII AU - Barbian, Kent D AU - Babar, Amenah AU - Dorward, David W AU - Holland, Steven M AD - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892. Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Hamilton, Montana 59840. Research Technologies Section, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Hamilton, Montana 59840 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 8727 EP - 8736 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 23 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - virulence factors KW - Genotyping KW - Nucleotide sequence KW - Fungi KW - Staphylococcus KW - Methanol KW - Transcription KW - Gluconobacter oxydans KW - Pathogens KW - DNA microarrays KW - Acetic acid KW - Lymph nodes KW - Fever KW - Guanylate cyclase KW - Lymphadenitis KW - Gram-negative bacteria KW - Chronic infection KW - DNA KW - Conservation KW - Chronic granulomatous disease KW - Open reading frames KW - J 02400:Human Diseases KW - N 14810:Methods KW - G 07770:Bacteria KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19900078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Genome+Sequence+Analysis+of+the+Emerging+Human+Pathogenic+Acetic+Acid+Bacterium+Granulibacter+bethesdensis&rft.au=Greenberg%2C+David+E%3BPorcella%2C+Stephen+F%3BZelazny%2C+Adrian+M%3BVirtaneva%2C+Kimmo%3BSturdevant%2C+Dan+E%3BKupko%2C+John+JIII%3BBarbian%2C+Kent+D%3BBabar%2C+Amenah%3BDorward%2C+David+W%3BHolland%2C+Steven+M&rft.aulast=Greenberg&rft.aufirst=David&rft.date=2007-12-01&rft.volume=189&rft.issue=23&rft.spage=8727&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; virulence factors; Fungi; Nucleotide sequence; Genotyping; Methanol; Transcription; Pathogens; Acetic acid; DNA microarrays; Lymph nodes; Fever; Guanylate cyclase; Lymphadenitis; Gram-negative bacteria; Chronic infection; DNA; Conservation; Chronic granulomatous disease; Open reading frames; Staphylococcus; Gluconobacter oxydans ER - TY - JOUR T1 - Intrauterine exposures and risk of endometriosis AN - 19716427; 7931849 AB - BACKGROUND: Intrauterine environmental exposures have been adversely associated with male reproductive health in contrast to limited investigation of such exposures and female reproductive health. METHODS: To address this research gap, a cohort comprising 84 women aged 18-40 years undergoing laparoscopy was recruited prior to surgery and followed through the post-operative period for endometriosis diagnosis. Women were interviewed about environmental exposures and those of their mothers while pregnant with them (use of alcohol, caffeinated beverages and cigarettes). Endometriosis was diagnosed in 32 women from the laparoscopy cohort; 52 women had no endometriosis visualized. Using unconditional logistic regression, odds ratios (OR) and 95% confidence intervals (CIs) were estimated for the intrauterine exposures adjusting for potential confounders. RESULTS: No significant associations were seen between intrauterine exposure to alcohol or caffeine and a diagnosis of endometriosis. Adjusting for age, significant reductions in odds of an endometriosis diagnosis were observed for intrauterine cigarette exposure both in the absence (OR 0.22, 95% CI 0.06-0.82) or presence (OR 0.05, 95% CI 0.01-0.42) of women's current smoking. CONCLUSIONS: While speculative, in utero cigarette exposure may be associated with a lower risk of surgically diagnosed adult-onset endometriosis, possibly as a result of alterations in hormonal milieu or pathologic angiogensis. JF - Human Reproduction AU - Buck Louis, Germaine M AU - Hediger, Mary L AU - Pena, Josefa B AD - Department of Health and Human Services, Epidemiology Branch, National Institute of Child Health & Human Development, 6100 Executive Blvd., Room 7B03, Rockville, Maryland 20852, USA. Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A & M University Health Science Center, College Station, Texas 77843, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3232 EP - 3236 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 12 SN - 0268-1161, 0268-1161 KW - Sustainability Science Abstracts KW - Alcohol KW - Age KW - Cigarettes KW - laparoscopy KW - Reproduction KW - surgery KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19716427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Intrauterine+exposures+and+risk+of+endometriosis&rft.au=Buck+Louis%2C+Germaine+M%3BHediger%2C+Mary+L%3BPena%2C+Josefa+B&rft.aulast=Buck+Louis&rft.aufirst=Germaine&rft.date=2007-12-01&rft.volume=22&rft.issue=12&rft.spage=3232&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Alcohol; Age; Cigarettes; Reproduction; laparoscopy; surgery ER - TY - JOUR T1 - Short communication: Occurrence of multidrug resistant Salmonella in antimicrobial-free (ABF) swine production systems AN - 19539994; 8338366 AB - This cross-sectional study was conducted to determine the prevalence and antimicrobial resistance of Salmonella species in swine reared in the intensive (indoor) and extensive (outdoor) ABF production systems at farm and slaughter in North Carolina, U.S.A. We sampled a total of 279 pigs at farm (extensive 107; intensive 172) and collected 274 carcass swabs (extensive 124; intensive 150) at slaughter. Salmonella species were tested for their susceptibility against 12 antimicrobial agents using the Kirby-Bauer disk diffusion method. Serogrouping was done using polyvalent and group specific antisera. A total of 400 salmonellae were isolated in this study with a significantly higher Salmonella prevalence from the intensive (30%) than the extensive farms (0.9%) (P < 0.001). At slaughter, significantly higher Salmonella was isolated at the pre- and post-evisceration stages from extensively (29% pre-evisceration and 33.3% post-evisceration) than the intensively (2% pre-evisceration and 6% post-evisceration) reared swine (P < 0.001). The isolates were clustered in six serogroups including B, C, E1, E4, G and R. Highest frequency of antimicrobial resistance was observed against tetracycline (78.5%) and streptomycin (31.5%). A total of 13 antimicrobial resistance patterns were observed including the pentaresistant strains with ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, tetracycline resistance pattern observed only among isolates from the intensive farms (n = 28) and all were serotype Salmonella typhimurium var. Copenhagen. In conclusion, this study shows that multidrug resistant Salmonella are prevalent in ABF production systems despite the absence of antimicrobial selection pressure. In addition, it also highlights the possible role played by slaughterhouse and other environmental factors in the contamination and dissemination of antimicrobial resistant Salmonella in ABF production systems. JF - Veterinary Microbiology AU - Thakur, Siddhartha AU - Tadesse, Daniel A AU - Morrow, Morgan AU - Gebreyes, Wondwossen A AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, United States, gebreyes.1@osu.edu Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 362 EP - 367 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 125 IS - 3-4 SN - 0378-1135, 0378-1135 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Swine KW - Salmonella species KW - Antimicrobial-free production system KW - Antimicrobials KW - Multidrug resistance KW - Chloramphenicol KW - Serotypes KW - Farms KW - Sulfamethoxazole KW - Contamination KW - Drug resistance KW - Ampicillin KW - Streptomycin KW - Salmonella typhimurium KW - Tetracyclines KW - Environmental factors KW - Antimicrobial agents KW - Antisera KW - Carcasses KW - Diffusion KW - Slaughter KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19539994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+Microbiology&rft.atitle=Short+communication%3A+Occurrence+of+multidrug+resistant+Salmonella+in+antimicrobial-free+%28ABF%29+swine+production+systems&rft.au=Thakur%2C+Siddhartha%3BTadesse%2C+Daniel+A%3BMorrow%2C+Morgan%3BGebreyes%2C+Wondwossen+A&rft.aulast=Thakur&rft.aufirst=Siddhartha&rft.date=2007-12-01&rft.volume=125&rft.issue=3-4&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Veterinary+Microbiology&rft.issn=03781135&rft_id=info:doi/10.1016%2Fj.vetmic.2007.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chloramphenicol; Farms; Serotypes; Contamination; Sulfamethoxazole; Drug resistance; Ampicillin; Streptomycin; Tetracyclines; Environmental factors; Antimicrobial agents; Antisera; Carcasses; Slaughter; Diffusion; Salmonella typhimurium DO - http://dx.doi.org/10.1016/j.vetmic.2007.05.025 ER - TY - JOUR T1 - Chronic lymphocytic leukaemia and radiation: findings among workers at five US nuclear facilities and a review of the recent literature AN - 1516751783; 7978354 AB - The aetiology of chronic lymphocytic leukaemia (CLL) is largely unknown. Despite compelling evidence for ionising radiation as a cause of most forms of leukaemia, CLL was not found to be radiogenic in early studies. Herein we describe the recent evidence for causation of CLL by ionising and non-ionising radiation, including a nested case-control study conducted within a cohort of 94 517 US workers at four nuclear weapons facilities and a nuclear naval shipyard. Forty-three cases of CLL deaths and 172 age-matched controls were identified with follow-up up to between 1990 and 1996. Radiation exposure from external sources and plutonium (lagged 10 years) was assessed for each worker, based on monitoring records. The excess relative rate (ERR) was estimated for workers receiving elevated doses compared to unexposed workers, controlling for possible risk factors. The ERR per 10 mSv was -0.020 (95% confidence interval: <0, 0.14) based on all exposed workers. However, for workers receiving <100 mSv, the ERR per 10 mSv was 0.20 (-0.035, 0.96). Recent studies of uranium miners and other populations have shown elevations of CLL possibly associated with ionising and non-ionising radiation. New studies should use incident cases and sufficient latency to account for the expected lengthy induction period for CLL. JF - British Journal of Haematology AU - Schubauer-Berigan, Mary K AU - Daniels, Robert D AU - Fleming, Donald A AU - Markey, Andrea M AU - Couch, James R AU - Ahrenholz, Steven H AU - Burphy, Jenneh S AU - Anderson, Jeri L AU - Tseng, Chih-Yu AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, OH, USA, zcg3@cdc.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 799 EP - 808 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 139 IS - 5 SN - 0007-1048, 0007-1048 KW - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Immunology Abstracts KW - chronic lymphocytic leukaemia KW - aetiology KW - epidemiology KW - Plutonium KW - Aetiology KW - Haematology KW - Workers KW - USA KW - Radiation KW - Literature reviews KW - Risk factors KW - Uranium KW - Chronic lymphatic leukemia KW - Occupational exposure KW - O 7020:Ships and Shipbuilding KW - F 06915:Cancer Immunology KW - Q5 08502:Methods and instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1516751783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Haematology&rft.atitle=Chronic+lymphocytic+leukaemia+and+radiation%3A+findings+among+workers+at+five+US+nuclear+facilities+and+a+review+of+the+recent+literature&rft.au=Schubauer-Berigan%2C+Mary+K%3BDaniels%2C+Robert+D%3BFleming%2C+Donald+A%3BMarkey%2C+Andrea+M%3BCouch%2C+James+R%3BAhrenholz%2C+Steven+H%3BBurphy%2C+Jenneh+S%3BAnderson%2C+Jeri+L%3BTseng%2C+Chih-Yu&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2007-12-01&rft.volume=139&rft.issue=5&rft.spage=799&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Haematology&rft.issn=00071048&rft_id=info:doi/10.1111%2Fj.1365-2141.2007.06843.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Plutonium; Literature reviews; Uranium; Aetiology; Haematology; Workers; Radiation; Risk factors; Chronic lymphatic leukemia; Occupational exposure; USA DO - http://dx.doi.org/10.1111/j.1365-2141.2007.06843.x ER - TY - JOUR T1 - Electromagnetic compatibility of pacemakers and implantable cardiac defibrillators exposed to RFID readers AN - 20502502; 9196294 JF - International Journal of Radio Frequency Identification Technology and Applications AU - Seidman, Seth J AU - Ruggera, Paul S AU - Brockman, Randall G AU - Lewis, Brian AU - Shein, Mitchell J AD - Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD 20993, USA. Y1 - 2007/11/25/ PY - 2007 DA - 2007 Nov 25 SP - 237 EP - 246 PB - Inderscience Publishers Ltd., PO Box 735 VL - 1 IS - 3 SN - 1745-3216, 1745-3216 KW - Biotechnology and Bioengineering Abstracts KW - COMPUTING JOURNALS KW - TECHNICAL JOURNALS KW - Communications and Mobile Technology KW - Information Systems and Technology KW - Materials and Manufacturing KW - Heart KW - Pacemakers KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20502502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radio+Frequency+Identification+Technology+and+Applications&rft.atitle=Electromagnetic+compatibility+of+pacemakers+and+implantable+cardiac+defibrillators+exposed+to+RFID+readers&rft.au=Seidman%2C+Seth+J%3BRuggera%2C+Paul+S%3BBrockman%2C+Randall+G%3BLewis%2C+Brian%3BShein%2C+Mitchell+J&rft.aulast=Seidman&rft.aufirst=Seth&rft.date=2007-11-25&rft.volume=1&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radio+Frequency+Identification+Technology+and+Applications&rft.issn=17453216&rft_id=info:doi/10.1504%2FIJRFITA.2007.015848 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Pacemakers DO - http://dx.doi.org/10.1504/IJRFITA.2007.015848 ER - TY - JOUR T1 - Brief communication: characteristics of spontaneous cases of tuberculosis associated with infliximab. AN - 68522532; 18025446 AB - A warning for tuberculosis was added to the approved labeling for infliximab in October 2001. To describe adverse event reports of tuberculosis during infliximab therapy after labeling changes. Case series. Spontaneous adverse event reports maintained in the Adverse Event Reporting System database in the United States. 130 patients with infliximab-associated tuberculosis. Clinical and laboratory data. The U.S. Food and Drug Administration received 130 domestic, spontaneous reports of tuberculosis in patients treated with infliximab between 1 November 2001 and 30 May 2006, including 59 (45%) with extrapulmonary disease. The most commonly reported risk factors included concomitant immunosuppressant use (n = 89), history of latent or active tuberculosis (n = 33), and being born into or having spent extensive time in an area where tuberculosis is endemic (n = 25). In the subset of 67 cases with documented initiation of infliximab therapy after the drug labeling change, 34 patients with a negative tuberculin skin test result before initiation of infliximab therapy developed tuberculosis after receiving infliximab. Conclusions from spontaneous case reports may not be generalizable to the entire infliximab-receiving population. Clinicians should be vigilant in screening and monitoring for tuberculosis in patients receiving infliximab. JF - Annals of internal medicine AU - Raval, Angela AU - Akhavan-Toyserkani, Gita AU - Brinker, Allen AU - Avigan, Mark AD - U. S. Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2007/11/20/ PY - 2007 DA - 2007 Nov 20 SP - 699 EP - 702 VL - 147 IS - 10 KW - Anti-Inflammatory Agents KW - 0 KW - Antibodies, Monoclonal KW - Infliximab KW - B72HH48FLU KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Aged KW - False Negative Reactions KW - Adverse Drug Reaction Reporting Systems KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Immunocompromised Host KW - Middle Aged KW - Adolescent KW - Tuberculin Test KW - Female KW - Male KW - Tuberculosis -- etiology KW - Anti-Inflammatory Agents -- adverse effects KW - Tuberculosis -- immunology KW - Tuberculosis -- diagnosis KW - Antibodies, Monoclonal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68522532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Brief+communication%3A+characteristics+of+spontaneous+cases+of+tuberculosis+associated+with+infliximab.&rft.au=Raval%2C+Angela%3BAkhavan-Toyserkani%2C+Gita%3BBrinker%2C+Allen%3BAvigan%2C+Mark&rft.aulast=Raval&rft.aufirst=Angela&rft.date=2007-11-20&rft.volume=147&rft.issue=10&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-28 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Elimination Plan of Measles in Canary Islands 2001-2005 T2 - 5th World Congress of the World Society for Pediatric Infectious Diseases (WSPID 2007) AN - 40754856; 4771715 JF - 5th World Congress of the World Society for Pediatric Infectious Diseases (WSPID 2007) AU - Rojas, A Garcia AU - Castellano, P Garcia AU - Herrera, M Trujillo AU - Romero, J Solis AU - Cruz, P Matute AU - Benitez, N Abadia AU - Santacruz, L Gonzalez AU - Gallo, D Nunez AU - Gonzalez, M.C. Perez AU - Capuz, B Lafarga Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 KW - Atlantic, Canary Is. KW - Islands KW - Measles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+World+Congress+of+the+World+Society+for+Pediatric+Infectious+Diseases+%28WSPID+2007%29&rft.atitle=Elimination+Plan+of+Measles+in+Canary+Islands+2001-2005&rft.au=Rojas%2C+A+Garcia%3BCastellano%2C+P+Garcia%3BHerrera%2C+M+Trujillo%3BRomero%2C+J+Solis%3BCruz%2C+P+Matute%3BBenitez%2C+N+Abadia%3BSantacruz%2C+L+Gonzalez%3BGallo%2C+D+Nunez%3BGonzalez%2C+M.C.+Perez%3BCapuz%2C+B+Lafarga&rft.aulast=Rojas&rft.aufirst=A&rft.date=2007-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+World+Congress+of+the+World+Society+for+Pediatric+Infectious+Diseases+%28WSPID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/wspid2007/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis AN - 19898747; 7786582 AB - Tamoxifen is a widely used anti-estrogenic drug for chemotherapy and, more recently, for the chemoprevention of breast cancer. Despite the indisputable benefits of tamoxifen in preventing the occurrence and re-occurrence of breast cancer, the use of tamoxifen has been shown to induce non-alcoholic steatohepatitis, which is a life-threatening fatty liver disease with a risk of progression to cirrhosis and hepatocellular carcinoma. In recent years, the high-throughput microarray technology for large-scale analysis of gene expression has become a powerful tool for increasing the understanding of the molecular mechanisms of carcinogenesis and for identifying new biomarkers with diagnostic and predictive values. In the present study, we used the high-throughput microarray technology to determine the gene expression profiles in the liver during early stages of tamoxifen-induced rat hepatocarcinogenesis. Female Fisher 344 rats were fed a 420 ppm tamoxifen containing diet for 12 or 24 weeks, and gene expression profiles were determined in liver of control and tamoxifen-exposed rats. The results indicate that early stages of tamoxifen-induced liver carcinogenesis are characterized by alterations in several major cellular pathways, specifically those involved in the tamoxifen metabolism, lipid metabolism, cell cycle signaling, and apoptosis/cell proliferation control. One of the most prominent changes during early stages of tamoxifen-induced hepatocarcinogenesis is dysregulation of signaling pathways in cell cycle progression from the G sub(1) to S phase, evidenced by the progressive and sustained increase in expression of the Pdgfc, Calb3, Ets1, and Ccnd1 genes accompanied by the elevated level of the PI3K, p-PI3K, Akt1/2, Akt3, and cyclin B, D1, and D3 proteins. The early appearance of these alterations suggests their importance in the mechanism of neoplastic cell transformation induced by tamoxifen. JF - Toxicology and Applied Pharmacology AU - Pogribny, I P AU - Bagnyukova, T V AU - Tryndyak, V P AU - Muskhelishvili, L AU - Rodriguez-Juarez, R AU - Kovalchuk, O AU - Han, T AU - Fuscoe, J C AU - Ross, SA AU - Beland, F A AD - National Center for Toxicological Research, Jefferson, AR 72079, USA, igor.pogribny@fda.hhs.gov Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 61 EP - 69 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 225 IS - 1 SN - 0041-008X, 0041-008X KW - Genetics Abstracts; Toxicology Abstracts KW - Diets KW - Transformation KW - Molecular modelling KW - Apoptosis KW - Cirrhosis KW - Ets-1 protein KW - Chemotherapy KW - Cell cycle KW - biomarkers KW - Tamoxifen KW - Lipid metabolism KW - Gene expression KW - Cyclin B KW - 1-Phosphatidylinositol 3-kinase KW - S phase KW - Carcinogenesis KW - Fatty liver KW - Breast cancer KW - AKT1 protein KW - Cell proliferation KW - Signal transduction KW - Hepatocellular carcinoma KW - X 24310:Pharmaceuticals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19898747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Gene+expression+profiling+reveals+underlying+molecular+mechanisms+of+the+early+stages+of+tamoxifen-induced+rat+hepatocarcinogenesis&rft.au=Pogribny%2C+I+P%3BBagnyukova%2C+T+V%3BTryndyak%2C+V+P%3BMuskhelishvili%2C+L%3BRodriguez-Juarez%2C+R%3BKovalchuk%2C+O%3BHan%2C+T%3BFuscoe%2C+J+C%3BRoss%2C+SA%3BBeland%2C+F+A&rft.aulast=Pogribny&rft.aufirst=I&rft.date=2007-11-15&rft.volume=225&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.07.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Diets; Molecular modelling; Cirrhosis; Apoptosis; Ets-1 protein; Chemotherapy; Cell cycle; Tamoxifen; biomarkers; Lipid metabolism; Gene expression; 1-Phosphatidylinositol 3-kinase; Cyclin B; S phase; Carcinogenesis; AKT1 protein; Breast cancer; Fatty liver; Cell proliferation; Hepatocellular carcinoma; Signal transduction DO - http://dx.doi.org/10.1016/j.taap.2007.07.001 ER - TY - JOUR T1 - Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues. AN - 68509434; 18003845 AB - In humans, exposure to environmental contexts previously associated with heroin intake can provoke drug relapse, but the neuronal mechanisms mediating this relapse are unknown. Using a drug relapse model, we found previously that reexposing rats to heroin-associated contexts, after extinction of drug-reinforced responding in different contexts, reinstates heroin seeking. This effect is attenuated by inhibition of glutamate transmission in the ventral tegmental area and medial accumbens shell, components of the mesolimbic dopamine system. Here, we explored the role of dopamine of the accumbens in context-induced reinstatement by using the D1-family receptor antagonist SCH 23390 [R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride]. Rats were trained to self-administer heroin for 12 d; drug infusions were paired with a discrete tone-light cue. Subsequently, the heroin-reinforced lever pressing was extinguished in the presence of the discrete cue in a context that differed from the drug self-administration context in terms of visual, auditory, tactile, and circadian cues. When tested in the original drug self-administration context, systemic and medial or lateral accumbens shell SCH 23390 injections attenuated context-induced reinstatement of heroin seeking, whereas accumbens core SCH 23390 injections were ineffective. In contrast, core but not lateral or medial shell SCH 23390 injections attenuated discrete-cue-induced reinstatement in a nondrug context after extinction of lever presses without this cue. Results indicate that activation of medial and lateral accumbens shell D1-family dopamine receptors mediate context-induced reinstatement of heroin seeking and provide the first demonstration for a role of lateral shell dopamine in conditioned drug effects. Results also demonstrate novel dissociable roles of accumbens core and shell in context- versus discrete-cue-induced reinstatement of heroin seeking. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Bossert, Jennifer M AU - Poles, Gabriela C AU - Wihbey, Kristina A AU - Koya, Eisuke AU - Shaham, Yavin AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 SP - 12655 EP - 12663 VL - 27 IS - 46 KW - Benzazepines KW - 0 KW - Dopamine Antagonists KW - Receptors, Dopamine D1 KW - Index Medicus KW - Animals KW - Benzazepines -- pharmacology KW - Rats, Long-Evans KW - Disease Models, Animal KW - Extinction, Psychological -- physiology KW - Conditioning (Psychology) -- drug effects KW - Rats KW - Behavior, Animal -- drug effects KW - Self Administration KW - Conditioning (Psychology) -- physiology KW - Cues KW - Behavior, Animal -- physiology KW - Benzazepines -- therapeutic use KW - Extinction, Psychological -- drug effects KW - Secondary Prevention KW - Male KW - Reward KW - Heroin Dependence -- metabolism KW - Dopamine Antagonists -- therapeutic use KW - Nucleus Accumbens -- drug effects KW - Receptors, Dopamine D1 -- antagonists & inhibitors KW - Heroin Dependence -- physiopathology KW - Dopamine Antagonists -- pharmacology KW - Heroin Dependence -- prevention & control KW - Nucleus Accumbens -- metabolism KW - Behavior, Addictive -- physiopathology KW - Nucleus Accumbens -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68509434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Differential+effects+of+blockade+of+dopamine+D1-family+receptors+in+nucleus+accumbens+core+or+shell+on+reinstatement+of+heroin+seeking+induced+by+contextual+and+discrete+cues.&rft.au=Bossert%2C+Jennifer+M%3BPoles%2C+Gabriela+C%3BWihbey%2C+Kristina+A%3BKoya%2C+Eisuke%3BShaham%2C+Yavin&rft.aulast=Bossert&rft.aufirst=Jennifer&rft.date=2007-11-14&rft.volume=27&rft.issue=46&rft.spage=12655&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-19 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Behav Neurosci. 1999 Apr;113(2):324-36 [10357457] Brain Res Rev. 2007 Nov;56(1):27-78 [17574681] Psychopharmacology (Berl). 2004 Nov;176(3-4):459-65 [15138757] J Neurosci. 2004 Nov 24;24(47):10726-30 [15564590] Neuropsychopharmacology. 2005 Feb;30(2):296-309 [15483559] Neuron. 2005 Mar 3;45(5):647-50 [15748840] J Neurosci. 2005 May 18;25(20):5061-5 [15901788] Neuroreport. 2005 Jun 21;16(9):1013-6 [15931079] Nat Neurosci. 2005 Nov;8(11):1481-9 [16251991] Eur J Pharmacol. 2005 Dec 5;526(1-3):36-50 [16289451] Neuropsychopharmacology. 2006 Feb;31(2):363-74 [15957007] Neuroscience. 2006;139(3):877-87 [16516392] Psychopharmacology (Berl). 2006 Aug;187(2):143-53 [16724186] Neuropsychopharmacology. 2006 Oct;31(10):2197-209 [16341024] Psychopharmacology (Berl). 2006 Nov;189(1):1-16 [17019567] Neuroscience. 2006 Nov 17;143(1):25-38 [16949214] Neuropsychopharmacology. 2008 May;33(6):1402-12 [17653111] Neuropsychopharmacology. 2008 May;33(6):1413-25 [17712353] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4321-6 [10760299] Neuroscience. 2000;99(2):267-77 [10938432] Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1976-81 [11172061] Psychopharmacology (Berl). 2001 Jun;156(1):98-107 [11465640] J Neurosci. 2001 Aug 1;21(15):5841-6 [11466456] Neuropsychopharmacology. 2001 Sep;25(3):361-72 [11522464] J Neurosci. 2001 Dec 1;21(23):9471-7 [11717381] Pharmacol Biochem Behav. 2002 Mar;71(3):517-29 [11830186] Pharmacol Rev. 2002 Mar;54(1):1-42 [11870259] Behav Neurosci. 2002 Feb;116(1):169-73 [11895178] Psychopharmacology (Berl). 2002 Apr;160(4):425-33 [11919670] J Neurosci. 2002 May 1;22(9):3312-20 [11978805] Neurosci Biobehav Rev. 2002 May;26(3):321-52 [12034134] Biol Psychiatry. 2002 Nov 15;52(10):976-86 [12437938] Neuropsychopharmacology. 2002 Dec;27(6):1006-15 [12464457] Neuropsychopharmacology. 2003 Feb;28(2):292-9 [12589382] Psychopharmacology (Berl). 2003 Jul;168(1-2):132-8 [12491029] J Neurosci. 2003 Jul 16;23(15):6295-303 [12867514] J Neurosci. 2003 Aug 13;23(19):7239-45 [12917356] J Neurosci. 2003 Oct 15;23(28):9305-11 [14561857] Neurosci Biobehav Rev. 2004 Jan;27(8):765-76 [15019426] Nat Neurosci. 2004 Apr;7(4):389-97 [15034590] Nat Rev Neurosci. 2004 Jun;5(6):483-94 [15152198] Trends Neurosci. 2004 Aug;27(8):468-74 [15271494] Neuropharmacology. 2004;47 Suppl 1:190-201 [15464137] Neuropharmacology. 2004;47 Suppl 1:227-41 [15464140] Arch Gen Psychiatry. 1973 May;28(5):611-6 [4700675] Brain Res. 1975 Mar 28;86(3):399-418 [234776] Pharmacol Rev. 1975 Sep;27(3):325-40 [817305] J Comp Neurol. 1978 Aug 1;180(3):545-80 [659674] Eur J Pharmacol. 1986 Oct 7;129(3):367-70 [3536532] Naunyn Schmiedebergs Arch Pharmacol. 1989 Mar;339(3):252-8 [2725702] J Comp Neurol. 1989 Nov 8;289(2):189-201 [2478598] Br J Pharmacol. 1991 Dec;104(4):1038-44 [1687364] Ann N Y Acad Sci. 1992 Jun 28;654:400-15 [1632593] Neuroscience. 1992 Sep;50(1):149-62 [1383869] Neuroscience. 1992 Oct;50(4):751-67 [1448200] Brain Res. 1995 Sep 18;692(1-2):47-56 [8548319] J Neurosci. 1996 Mar 1;16(5):1957-63 [8774462] Eur J Neurosci. 1997 Dec;9(12):2541-8 [9517459] Neuroscience. 1999 Mar;89(2):473-89 [10077329] Psychopharmacology (Berl). 2007 Apr;191(3):689-703 [17072592] Neuroscience. 2007 May 11;146(2):525-36 [17360123] Ann N Y Acad Sci. 1999 Jun 29;877:140-56 [10415648] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Role of Cofilin-1 in Taurine Chloramine-Induced Premature Senescence of Human Lung Fibroblasts. T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40707161; 4755904 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Zdanov, Stephanie AU - Shacter, Emily Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Lung KW - Senescence KW - Fibroblasts KW - Taurine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40707161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Role+of+Cofilin-1+in+Taurine+Chloramine-Induced+Premature+Senescence+of+Human+Lung+Fibroblasts.&rft.au=Zdanov%2C+Stephanie%3BShacter%2C+Emily&rft.aulast=Zdanov&rft.aufirst=Stephanie&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mitochondrially-Targeted Redox Agent Mitoquinone Enhances Doxorubicin-Induced Toxicity to Breast Cancer Cells While Protecting Cardiac Myocytes T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40705413; 4755903 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Rao, V Ashutosh AU - Klein, Sarah AU - Zielonka, Jacek AU - Kalyanaraman, B AU - Shacter, Emily Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Toxicity KW - Breast cancer KW - Cardiomyocytes KW - Mitochondria KW - Redox reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=The+Mitochondrially-Targeted+Redox+Agent+Mitoquinone+Enhances+Doxorubicin-Induced+Toxicity+to+Breast+Cancer+Cells+While+Protecting+Cardiac+Myocytes&rft.au=Rao%2C+V+Ashutosh%3BKlein%2C+Sarah%3BZielonka%2C+Jacek%3BKalyanaraman%2C+B%3BShacter%2C+Emily&rft.aulast=Rao&rft.aufirst=V&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of Phototoxicity, Crystalline Form and Light-Induced Free Radical Formation for Tattoo Inks Containing TiO2 T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40704945; 4755817 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Wamer, Wayne AU - Yin, Jun Jie Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Tattoos KW - Phototoxicity KW - Free radicals KW - Light effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Determination+of+Phototoxicity%2C+Crystalline+Form+and+Light-Induced+Free+Radical+Formation+for+Tattoo+Inks+Containing+TiO2&rft.au=Wamer%2C+Wayne%3BYin%2C+Jun+Jie&rft.aulast=Wamer&rft.aufirst=Wayne&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of In Vitro Assay for Rapid Evaluation of Activity and Safety of New Adjuvants. T2 - Second International Conference on Modern Vaccine / Adjuvant Formulation (MVAF 2007) AN - 40739101; 4770403 JF - Second International Conference on Modern Vaccine / Adjuvant Formulation (MVAF 2007) AU - Zaitseva, Marina AU - Romantseva, Tatiana AU - Golding, Hana Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 KW - Adjuvants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40739101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+Modern+Vaccine+%2F+Adjuvant+Formulation+%28MVAF+2007%29&rft.atitle=Development+of+In+Vitro+Assay+for+Rapid+Evaluation+of+Activity+and+Safety+of+New+Adjuvants.&rft.au=Zaitseva%2C+Marina%3BRomantseva%2C+Tatiana%3BGolding%2C+Hana&rft.aulast=Zaitseva&rft.aufirst=Marina&rft.date=2007-11-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+Modern+Vaccine+%2F+Adjuvant+Formulation+%28MVAF+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/mvaf_2007/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Second Cancers Among 104760 Survivors of Cervical Cancer: Evaluation of Long-Term Risk AN - 20374165; 7743536 AB - BACKGROUND: Given the extended survival of patients diagnosed with cervical cancer, the large number of these women treated with radiotherapy, and the presence in this population of established cancer risk factors such as human papillomavirus (HPV) infection and cigarette smoking, it is important to clarify long-term trends in second cancer risk. METHODS: Using data from 104760 one-year survivors of cervical cancer reported to 13 population-based cancer registries in Denmark, Finland, Norway, Sweden, and the United States, we calculated standardized incidence ratios (SIRs) for second cancers overall and cancers at particular sites among women with cervical cancer, including cervical cancer patients who were treated or not treated with radiation, over more than 40 years of follow-up. Cox regression models were used to assess the time-varying association of radiotherapy with risk of second cancers and to assess the interaction of radiation treatment with age at diagnosis. All statistical tests were two-sided. RESULTS: Among 104760 one-year survivors of cervical cancer, the risk of all second cancers taken together was increased to a statistically significant extent (n = 12496; SIR = 1.30; 95% confidence interval [CI] = 1.28 to 1.33). Compared with the general population, in both radiotherapy (N = 52613) and no-radiotherapy groups (N = 27382), risks for HPV-related cancers (of the pharynx, genital sites, and rectum/anus) and smoking-related cancers (of the pharynx, trachea/bronchus/lung, pancreas, and urinary bladder) were elevated to a statistically significant extent. Cervical cancer patients treated with radiotherapy, but not those who did not receive radiotherapy, were at increased risk for all second cancers and cancers at heavily irradiated sites (colon, rectum/anus, urinary bladder, ovary, and genital sites) beyond 40 years of follow-up compared with women in the general population. The association of radiotherapy with second cancer risk was modified by age at cervical cancer diagnosis for rectum/anus, genital sites, and urinary bladder, with higher hazard ratios for second cancer at younger ages of cervical cancer. After adjustment for competing mortality, the 40-year cumulative risk of any second cancer was higher among women diagnosed with cervical cancer before age 50 (22.2%; 95% CI = 21.5% to 22.8%) than among women diagnosed after age 50 (16.4%; 95% CI = 16.1% to 16.9%). CONCLUSION: Cervical cancer patients treated with radiotherapy are at increased risk of second cancers at sites in close proximity to the cervix beyond 40 years of follow-up. JF - Journal of the National Cancer Institute AU - Chaturvedi, Anil K AU - Engels, Eric A AU - Gilbert, Ethel S AU - Chen, Bingshu E AU - Storm, Hans AU - Lynch, Charles F AU - Hall, Per AU - Langmark, Froydis AU - Pukkala, Eero AU - Kaijser, Magnus AU - Andersson, Michael AU - Fossaa, Sophie D AU - Joensuu, Heikki AU - Boice, John D AU - Kleinerman, Ruth A AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (AKC, EAE, ESG, BEC, RAK, LBT) Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 SP - 1634 EP - 1643 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 21 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - Age KW - Finland KW - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir KW - radiotherapy KW - Cancer KW - urinary bladder KW - USA KW - Lung KW - Cigarette smoking KW - infection KW - Denmark KW - Norway KW - survival KW - Sweden KW - Human papillomavirus KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20374165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Second+Cancers+Among+104760+Survivors+of+Cervical+Cancer%3A+Evaluation+of+Long-Term+Risk&rft.au=Chaturvedi%2C+Anil+K%3BEngels%2C+Eric+A%3BGilbert%2C+Ethel+S%3BChen%2C+Bingshu+E%3BStorm%2C+Hans%3BLynch%2C+Charles+F%3BHall%2C+Per%3BLangmark%2C+Froydis%3BPukkala%2C+Eero%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BFossaa%2C+Sophie+D%3BJoensuu%2C+Heikki%3BBoice%2C+John+D%3BKleinerman%2C+Ruth+A%3BTravis%2C+Lois+B&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2007-11-07&rft.volume=99&rft.issue=21&rft.spage=1634&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; urinary bladder; Age; Lung; Cigarette smoking; infection; survival; radiotherapy; Cancer; Human papillomavirus; USA; Finland; ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir; Denmark; Norway; Sweden ER - TY - JOUR T1 - Prospective Study of Serum Vitamin D and Cancer Mortality in the United States AN - 20373976; 7743532 AB - BACKGROUND: Vitamin D has been hypothesized to reduce cancer mortality through its effects on incidence and/or survival. Epidemiologic studies of the association of 25-hydroxyvitamin D [25(OH)D] and the risk of cancer, however, have been largely limited to incident cancers at a few sites. METHODS: A total of 16818 participants in the Third National Health and Nutrition Examination Survey who were 17 years or older at enrollment were followed from 1988-1994 through 2000. Levels of serum 25(OH)D were measured at baseline by radioimmunoassay. Cox proportional hazards regression models were used to examine the relationship between serum 25(OH)D levels and total cancer mortality (in the entire population or according to race/ethnicity, sex, age, and retinol status) and mortality from specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season. All statistical tests were two-sided. RESULTS: We identified 536 cancer deaths in 146578 person-years. Total cancer mortality was unrelated to baseline vitamin D status in the entire population, men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans, and in persons younger than 70 or 70 years or older. We found no interaction between vitamin D and season or vitamin D and serum retinol. Colorectal cancer mortality was inversely related to serum 25(OH)D level, with levels 80 nmol/L or higher associated with a 72% risk reduction (95% confidence interval = 32% to 89%) compared with lower than 50 nmol/L, P sub(trend) = .02. CONCLUSIONS: Our results do not support an association between 25(OH)D and total cancer mortality, although there was an inverse relationship between 25(OH)D levels and colorectal cancer mortality. JF - Journal of the National Cancer Institute AU - Freedman, DMichal AU - Looker, Anne C AU - Chang, Shih-Chen AU - Graubard, Barry I AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (DMF, SCC, BIG) Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 SP - 1594 EP - 1602 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 21 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - risk reduction KW - USA KW - Age KW - vitamins KW - survival KW - Nutrition KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Prospective+Study+of+Serum+Vitamin+D+and+Cancer+Mortality+in+the+United+States&rft.au=Freedman%2C+DMichal%3BLooker%2C+Anne+C%3BChang%2C+Shih-Chen%3BGraubard%2C+Barry+I&rft.aulast=Freedman&rft.aufirst=DMichal&rft.date=2007-11-07&rft.volume=99&rft.issue=21&rft.spage=1594&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - risk reduction; Mortality; Age; vitamins; survival; Nutrition; Ethnic groups; Cancer; USA ER - TY - JOUR T1 - FDA's application of toxicological thresholds and structure activity analysis AN - 19466451; 8237703 JF - Toxicology AU - Cheeseman, MA AU - Dowla, N AU - McDougal, A J AU - Yang, C AD - HFS-200, 5100 Paint Branch Pkwy, College Park, MD 20740, USA, Mitchell.Cheeseman@fda.hhs.gov Y1 - 2007/11/06/ PY - 2007 DA - 2007 Nov 06 SP - 130 EP - 131 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 240 IS - 3 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Toxicology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19466451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=FDA%27s+application+of+toxicological+thresholds+and+structure+activity+analysis&rft.au=Cheeseman%2C+MA%3BDowla%2C+N%3BMcDougal%2C+A+J%3BYang%2C+C&rft.aulast=Cheeseman&rft.aufirst=MA&rft.date=2007-11-06&rft.volume=240&rft.issue=3&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2007.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Toxicology DO - http://dx.doi.org/10.1016/j.tox.2007.06.006 ER - TY - CPAPER T1 - Glycosylation of the Dengue 2 Virus E Protein at N67 is Critical for Virus Growth in Vitro but not for Growth in Intrathoracically-Inoculated Aedes aegypti Mosquitoes T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40747873; 4776812 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Roehrig, John T AU - Bryant, Juliet E AU - Calvert, Amanda E AU - Mesesan, Kyeen AU - Crabtree, Mary B AU - Volpe, Katharine E AU - Silengo, Shawn AU - Kinney, Richard M AU - Huang, Claire Y AU - Miller, Barry R Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Dengue KW - E protein KW - Glycosylation KW - Public health KW - Aquatic insects KW - Growth KW - Aedes aegypti KW - Dengue virus type 2 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40747873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Glycosylation+of+the+Dengue+2+Virus+E+Protein+at+N67+is+Critical+for+Virus+Growth+in+Vitro+but+not+for+Growth+in+Intrathoracically-Inoculated+Aedes+aegypti+Mosquitoes&rft.au=Roehrig%2C+John+T%3BBryant%2C+Juliet+E%3BCalvert%2C+Amanda+E%3BMesesan%2C+Kyeen%3BCrabtree%2C+Mary+B%3BVolpe%2C+Katharine+E%3BSilengo%2C+Shawn%3BKinney%2C+Richard+M%3BHuang%2C+Claire+Y%3BMiller%2C+Barry+R&rft.aulast=Roehrig&rft.aufirst=John&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Innovative Health Education: Using Media and Technology to Get Today's Youth to Eat Healthy and be Physically Active T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40782194; 4784015 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Dobday, Christine AU - Penn, Cecilia Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Education KW - Technology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Innovative+Health+Education%3A+Using+Media+and+Technology+to+Get+Today%27s+Youth+to+Eat+Healthy+and+be+Physically+Active&rft.au=Dobday%2C+Christine%3BPenn%2C+Cecilia&rft.aulast=Dobday&rft.aufirst=Christine&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluating the WOMAN Challenge: Women and Girls Out Moving Across the Nation T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40782175; 4784008 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hoersch, Michelle D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Evaluating+the+WOMAN+Challenge%3A+Women+and+Girls+Out+Moving+Across+the+Nation&rft.au=Hoersch%2C+Michelle+D&rft.aulast=Hoersch&rft.aufirst=Michelle&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Health Promoters, as Part of a School-Based Health Center Health Promotion Program, to Gain Access to Underserved and Hard-to-Reach Families T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40781940; 4784447 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hodge, Mark AU - Covich, Judith AU - Glick, Joan AU - Chin, Jonathan Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Health promotion KW - Promoters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40781940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Using+Health+Promoters%2C+as+Part+of+a+School-Based+Health+Center+Health+Promotion+Program%2C+to+Gain+Access+to+Underserved+and+Hard-to-Reach+Families&rft.au=Hodge%2C+Mark%3BCovich%2C+Judith%3BGlick%2C+Joan%3BChin%2C+Jonathan&rft.aulast=Hodge&rft.aufirst=Mark&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV/AIDS Protective Factors among Sexually Active African and Hispanic/Latino Adolescents T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40780440; 4784412 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Bellamy, Nikki D AU - Wang, Min Qi Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Africa KW - Ethnic groups KW - Human immunodeficiency virus KW - Adolescents KW - Acquired immune deficiency syndrome KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40780440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=HIV%2FAIDS+Protective+Factors+among+Sexually+Active+African+and+Hispanic%2FLatino+Adolescents&rft.au=Bellamy%2C+Nikki+D%3BWang%2C+Min+Qi&rft.aulast=Bellamy&rft.aufirst=Nikki&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challenges of Evaluating Health Marketing Campaigns: A Look at SPOT THE BLOCK T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40777483; 4784115 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Davidson, Marjorie Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Marketing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Challenges+of+Evaluating+Health+Marketing+Campaigns%3A+A+Look+at+SPOT+THE+BLOCK&rft.au=Davidson%2C+Marjorie&rft.aulast=Davidson&rft.aufirst=Marjorie&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Communicating Disease Prevention Information to the Public: Research-Based Guidelines for Creating Effective Web Content T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40777278; 4784014 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hilfiker, Sandra Williams AU - Robison, Stacy Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - Guidelines KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Communicating+Disease+Prevention+Information+to+the+Public%3A+Research-Based+Guidelines+for+Creating+Effective+Web+Content&rft.au=Hilfiker%2C+Sandra+Williams%3BRobison%2C+Stacy&rft.aulast=Hilfiker&rft.aufirst=Sandra&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What's the Mix between Policy Decisions and Alcohol Damage: International, National, and State Perspectives T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40777165; 4784410 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Mahony, Ann Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Alcohols KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=What%27s+the+Mix+between+Policy+Decisions+and+Alcohol+Damage%3A+International%2C+National%2C+and+State+Perspectives&rft.au=Mahony%2C+Ann&rft.aulast=Mahony&rft.aufirst=Ann&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy Start: Learning Communities for Interconceptional Health T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40777116; 4783954 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Badura, Maribeth Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Healthy+Start%3A+Learning+Communities+for+Interconceptional+Health&rft.au=Badura%2C+Maribeth&rft.aulast=Badura&rft.aufirst=Maribeth&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lead Exposure among Women of Child-Bearing Age United States, 2004. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40775801; 4782024 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Luckhaupt, Sara E AU - Calvert, Geoffrey M AU - Roscoe, Robert J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Lead KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Lead+Exposure+among+Women+of+Child-Bearing+Age+United+States%2C+2004.&rft.au=Luckhaupt%2C+Sara+E%3BCalvert%2C+Geoffrey+M%3BRoscoe%2C+Robert+J&rft.aulast=Luckhaupt&rft.aufirst=Sara&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protecting Workers who Spray-On Truck Bed Liners: Understanding Audience Perceptions and Information Dissemination. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40775772; 4782021 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hudson, Heidi AU - Stirnkorb, Anne AU - Almaguer, Dan AU - Ernst, Kathy AU - Jones, Brenda J AU - Ziegler, Tom E Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Perception KW - Trucks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Protecting+Workers+who+Spray-On+Truck+Bed+Liners%3A+Understanding+Audience+Perceptions+and+Information+Dissemination.&rft.au=Hudson%2C+Heidi%3BStirnkorb%2C+Anne%3BAlmaguer%2C+Dan%3BErnst%2C+Kathy%3BJones%2C+Brenda+J%3BZiegler%2C+Tom+E&rft.aulast=Hudson&rft.aufirst=Heidi&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Garrett Lee Smith Memorial Campus Suicide Prevention Program: Lessons Learned and Unique Successes during the First Year T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40775427; 4784044 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Zeller, Eileen F AU - Davis, Nancy J AU - Hansen, Cynthia K AU - McKeon, Richard AU - Ritchie, Gail F AU - Mannix, Danyelle Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Suicide KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Garrett+Lee+Smith+Memorial+Campus+Suicide+Prevention+Program%3A+Lessons+Learned+and+Unique+Successes+during+the+First+Year&rft.au=Zeller%2C+Eileen+F%3BDavis%2C+Nancy+J%3BHansen%2C+Cynthia+K%3BMcKeon%2C+Richard%3BRitchie%2C+Gail+F%3BMannix%2C+Danyelle&rft.aulast=Zeller&rft.aufirst=Eileen&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Update on the OWH Pregnancy Exposure Registry Listing T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40774847; 4784009 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sharma, Pellavi AU - Parekh, Ameeta AU - Duvall-Miller, Elizabeth AU - O'Leary, Connie AU - Uhl, Kathleen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Pregnancy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40774847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=An+Update+on+the+OWH+Pregnancy+Exposure+Registry+Listing&rft.au=Sharma%2C+Pellavi%3BParekh%2C+Ameeta%3BDuvall-Miller%2C+Elizabeth%3BO%27Leary%2C+Connie%3BUhl%2C+Kathleen&rft.aulast=Sharma&rft.aufirst=Pellavi&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medicaid Asthma-Related Prescription Fills and the Associated Program Expenditures for Individuals Who had a Current Diagnosis of Asthma and an Ambulatory Service in CY 2002 Using the HHS/NIH/NHLBI NAEPP Guidelines: Age, Gender, and Race/Ethnicity Variations T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40773580; 4783834 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Benedict, M Beth Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sex KW - Respiratory diseases KW - Asthma KW - Ethnic groups KW - Guidelines KW - Age KW - Races KW - Subpopulations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40773580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Medicaid+Asthma-Related+Prescription+Fills+and+the+Associated+Program+Expenditures+for+Individuals+Who+had+a+Current+Diagnosis+of+Asthma+and+an+Ambulatory+Service+in+CY+2002+Using+the+HHS%2FNIH%2FNHLBI+NAEPP+Guidelines%3A+Age%2C+Gender%2C+and+Race%2FEthnicity+Variations&rft.au=Benedict%2C+M+Beth&rft.aulast=Benedict&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Supplements Labels Information for Consumers T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40771653; 4781380 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Goshorn, Jeanne C AU - Chang, H Florence AU - Moore, Dorothy R AU - Sun, Ying AU - Hudson, Vera H AU - Hazard, George F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Dietary supplements KW - Consumers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Dietary+Supplements+Labels+Information+for+Consumers&rft.au=Goshorn%2C+Jeanne+C%3BChang%2C+H+Florence%3BMoore%2C+Dorothy+R%3BSun%2C+Ying%3BHudson%2C+Vera+H%3BHazard%2C+George+F&rft.aulast=Goshorn&rft.aufirst=Jeanne&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Do U.S. Consumers Handle Precut Bagged Lettuce? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40771534; 4781450 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lin, Chung-Tung Jordan AU - Verrill, Linda A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Consumers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=How+Do+U.S.+Consumers+Handle+Precut+Bagged+Lettuce%3F&rft.au=Lin%2C+Chung-Tung+Jordan%3BVerrill%2C+Linda+A&rft.aulast=Lin&rft.aufirst=Chung-Tung&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environmental Justice for Immigrant Workers: Research Methods to Promote Public Health T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40770116; 4780528 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Baron, Sherry L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Public health KW - Immigrants KW - Research methods KW - Environmental equity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40770116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Environmental+Justice+for+Immigrant+Workers%3A+Research+Methods+to+Promote+Public+Health&rft.au=Baron%2C+Sherry+L&rft.aulast=Baron&rft.aufirst=Sherry&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Reporting of HCAHPS in Context. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769542; 4781994 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Miranda, David J AU - Carman, Kristin L AU - McGee, Jeanne Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hospitals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Public+Reporting+of+HCAHPS+in+Context.&rft.au=Miranda%2C+David+J%3BCarman%2C+Kristin+L%3BMcGee%2C+Jeanne&rft.aulast=Miranda&rft.aufirst=David&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Physical Workload and Low Back Disorders: Does Fairness Matter? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769400; 4782037 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fujishiro, Kaori AU - Heaney, Catherine A AU - Ferguson, Sue A AU - Allread, W Gary AU - Marras, William S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Working conditions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Physical+Workload+and+Low+Back+Disorders%3A+Does+Fairness+Matter%3F&rft.au=Fujishiro%2C+Kaori%3BHeaney%2C+Catherine+A%3BFerguson%2C+Sue+A%3BAllread%2C+W+Gary%3BMarras%2C+William+S&rft.aulast=Fujishiro&rft.aufirst=Kaori&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Workplace Lactation Lounge in Chicago T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769313; 4784318 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hoersch, Michelle D AU - Dolgin, Amy F AU - Rosenthal, Emily Gerson Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA, Illinois, Chicago KW - Lactation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Development+of+a+Workplace+Lactation+Lounge+in+Chicago&rft.au=Hoersch%2C+Michelle+D%3BDolgin%2C+Amy+F%3BRosenthal%2C+Emily+Gerson&rft.aulast=Hoersch&rft.aufirst=Michelle&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conducting an Assessment and Intervention in Houston's Inner City T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769195; 4780427 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Vassallo, Angela AU - Hickenbotham, Algia AU - Gamble, Rick AU - Patterson, Pam Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Inner cities KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Conducting+an+Assessment+and+Intervention+in+Houston%27s+Inner+City&rft.au=Vassallo%2C+Angela%3BHickenbotham%2C+Algia%3BGamble%2C+Rick%3BPatterson%2C+Pam&rft.aulast=Vassallo&rft.aufirst=Angela&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Employee Assistance and Health/Wellness Programs T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769085; 4780144 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Galvin, Deborah Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Personnel KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Employee+Assistance+and+Health%2FWellness+Programs&rft.au=Galvin%2C+Deborah&rft.aulast=Galvin&rft.aufirst=Deborah&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quality of Inpatient Care Provided for Older Patients with Acute Myocardial Infarction (AMI): Findings from the National Healthcare Quality Report (NHQR). T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768627; 4781989 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Gray, Darryl T AU - Brady, P Jeffrey Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Myocardial infarction KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Quality+of+Inpatient+Care+Provided+for+Older+Patients+with+Acute+Myocardial+Infarction+%28AMI%29%3A+Findings+from+the+National+Healthcare+Quality+Report+%28NHQR%29.&rft.au=Gray%2C+Darryl+T%3BBrady%2C+P+Jeffrey&rft.aulast=Gray&rft.aufirst=Darryl&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Missed Opportunities for Prevention: Overview of Findings from the 2006 National Healthcare Quality Report. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768591; 4781987 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Brady, P Jeffrey Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - Health care KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Missed+Opportunities+for+Prevention%3A+Overview+of+Findings+from+the+2006+National+Healthcare+Quality+Report.&rft.au=Brady%2C+P+Jeffrey&rft.aulast=Brady&rft.aufirst=P&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ventilator-Associated Pneumonia among Medicare Beneficiaries in Long-Term Care Hospitals. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768418; 4781975 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Buczko, William Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hospitals KW - Ventilator-associated pneumonia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Ventilator-Associated+Pneumonia+among+Medicare+Beneficiaries+in+Long-Term+Care+Hospitals.&rft.au=Buczko%2C+William&rft.aulast=Buczko&rft.aufirst=William&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variation of the Supply and Cost of Treat-and-Release Visits to Hospital Emergency Departments T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768307; 4783721 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Friedman, Bernard AU - Owens, Pamela J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hospitals KW - Emergencies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Variation+of+the+Supply+and+Cost+of+Treat-and-Release+Visits+to+Hospital+Emergency+Departments&rft.au=Friedman%2C+Bernard%3BOwens%2C+Pamela+J&rft.aulast=Friedman&rft.aufirst=Bernard&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Flu Shots at Polling Sites: Partisan Politics or Public Health? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767986; 4783676 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Akyea, Oyeba Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Politics KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Flu+Shots+at+Polling+Sites%3A+Partisan+Politics+or+Public+Health%3F&rft.au=Akyea%2C+Oyeba&rft.aulast=Akyea&rft.aufirst=Oyeba&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the National Breastfeeding Awareness Campaign (Babies Were Born to be Breastfed): Is Risk Susceptibility Associated with Higher Breastfeeding Rates? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767876; 4781400 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Haynes, Suzanne G AU - Merewood, Anne AU - Chaudhuri, Jana AU - Fein, Sara B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Breast feeding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Evaluation+of+the+National+Breastfeeding+Awareness+Campaign+%28Babies+Were+Born+to+be+Breastfed%29%3A+Is+Risk+Susceptibility+Associated+with+Higher+Breastfeeding+Rates%3F&rft.au=Haynes%2C+Suzanne+G%3BMerewood%2C+Anne%3BChaudhuri%2C+Jana%3BFein%2C+Sara+B&rft.aulast=Haynes&rft.aufirst=Suzanne&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence and Profile of HIV Antibody Testing among High Risk Adults T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767843; 4783600 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Bellamy, Nikki D AU - Wang, Min Qi Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Human immunodeficiency virus KW - Antibodies KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Prevalence+and+Profile+of+HIV+Antibody+Testing+among+High+Risk+Adults&rft.au=Bellamy%2C+Nikki+D%3BWang%2C+Min+Qi&rft.aulast=Bellamy&rft.aufirst=Nikki&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy People 2020: Developing National Objectives for the Next Decade T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767828; 4784291 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Royall, Penelope AU - Blakey, Carter AU - Paxman, Dalton G AU - Klein, Richard Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Healthy+People+2020%3A+Developing+National+Objectives+for+the+Next+Decade&rft.au=Royall%2C+Penelope%3BBlakey%2C+Carter%3BPaxman%2C+Dalton+G%3BKlein%2C+Richard&rft.aulast=Royall&rft.aufirst=Penelope&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infant Formula use Education and Safety T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767744; 4781451 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Labiner-Wolfe, Judith AU - Fein, Sara B AU - Shealy, Katherine Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Education KW - Infant formulas KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Infant+Formula+use+Education+and+Safety&rft.au=Labiner-Wolfe%2C+Judith%3BFein%2C+Sara+B%3BShealy%2C+Katherine&rft.aulast=Labiner-Wolfe&rft.aufirst=Judith&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infant Feeding Practices Study: Methods and Sample Characteristics T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767641; 4781395 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fein, Sara B AU - Labiner-Wolfe, Judith AU - Shealy, Katherine AU - Grummer-Strawn, Laurence AU - Li, Ruowei Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Infants KW - Feeding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Infant+Feeding+Practices+Study%3A+Methods+and+Sample+Characteristics&rft.au=Fein%2C+Sara+B%3BLabiner-Wolfe%2C+Judith%3BShealy%2C+Katherine%3BGrummer-Strawn%2C+Laurence%3BLi%2C+Ruowei&rft.aulast=Fein&rft.aufirst=Sara&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Health Infrastructure at Ports of Entry: Developing Effective Training Materials for U.S. Customs and Border Protection Officers T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767446; 4780464 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hunter, David AU - Benenson, Gabrielle Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Customs KW - Public health KW - Training KW - Port installations KW - Infrastructure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Public+Health+Infrastructure+at+Ports+of+Entry%3A+Developing+Effective+Training+Materials+for+U.S.+Customs+and+Border+Protection+Officers&rft.au=Hunter%2C+David%3BBenenson%2C+Gabrielle&rft.aulast=Hunter&rft.aufirst=David&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Overview of the International Health Regulations (IHR): The U.S National Perspective T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767382; 4784308 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Jajosky, Ruth Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=An+Overview+of+the+International+Health+Regulations+%28IHR%29%3A+The+U.S+National+Perspective&rft.au=Jajosky%2C+Ruth&rft.aulast=Jajosky&rft.aufirst=Ruth&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy People 2010: Oral Health and Looking Ahead T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767130; 4782841 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Ochiai, Emmeline AU - Royall, Penelope Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Healthy+People+2010%3A+Oral+Health+and+Looking+Ahead&rft.au=Ochiai%2C+Emmeline%3BRoyall%2C+Penelope&rft.aulast=Ochiai&rft.aufirst=Emmeline&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Widening Disparities in Infant, Neonatal, and Postneonatal Mortality among Major US Metropolitan Cities, 1985-2002 T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767074; 4783573 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Singh, Gopal K AU - Kogan, Michael D AU - Hummer, Robert A AU - Van Dyck, Peter C AU - Badura, Maribeth AU - Hench, Karen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Urban areas KW - Mortality KW - Infants KW - Neonates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Widening+Disparities+in+Infant%2C+Neonatal%2C+and+Postneonatal+Mortality+among+Major+US+Metropolitan+Cities%2C+1985-2002&rft.au=Singh%2C+Gopal+K%3BKogan%2C+Michael+D%3BHummer%2C+Robert+A%3BVan+Dyck%2C+Peter+C%3BBadura%2C+Maribeth%3BHench%2C+Karen&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Criminalization Hypothesis: An Historical Policy Analysis T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766984; 4783731 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Morabito, Melissa Schaefer AU - Draine, Jeff Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Historical account KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Criminalization+Hypothesis%3A+An+Historical+Policy+Analysis&rft.au=Morabito%2C+Melissa+Schaefer%3BDraine%2C+Jeff&rft.aulast=Morabito&rft.aufirst=Melissa&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Concordance of Household and Provider Reported Medical Conditions in the Medical Expenditure Panel Survey. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766587; 4782127 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Machlin, Steven AU - Beauregard, Karen M AU - Cohen, Joel Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Households KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Concordance+of+Household+and+Provider+Reported+Medical+Conditions+in+the+Medical+Expenditure+Panel+Survey.&rft.au=Machlin%2C+Steven%3BBeauregard%2C+Karen+M%3BCohen%2C+Joel&rft.aulast=Machlin&rft.aufirst=Steven&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health Disparities in Cancer Screening among US Women Workers. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766524; 4782091 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fleming, Lora E AU - Lee, David AU - Christ, Sharon L AU - McCollister, Kathryn E AU - Arheart, Kristopher L AU - LeBlanc, William G AU - Caban-Martinez, Alberto J AU - Chung-Bridges, Katherine Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Health+Disparities+in+Cancer+Screening+among+US+Women+Workers.&rft.au=Fleming%2C+Lora+E%3BLee%2C+David%3BChrist%2C+Sharon+L%3BMcCollister%2C+Kathryn+E%3BArheart%2C+Kristopher+L%3BLeBlanc%2C+William+G%3BCaban-Martinez%2C+Alberto+J%3BChung-Bridges%2C+Katherine&rft.aulast=Fleming&rft.aufirst=Lora&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enrollment of Women and Racial Minorities in Clinical Trials for Diabetes Medications T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766358; 4783331 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Pinnow, Ellen AU - Sharma, Pellavi AU - Parekh, Ameeta AU - Thomas, Kimberly AU - Aljuburi, Lina AU - Uhl, Kathleen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Clinical trials KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Enrollment+of+Women+and+Racial+Minorities+in+Clinical+Trials+for+Diabetes+Medications&rft.au=Pinnow%2C+Ellen%3BSharma%2C+Pellavi%3BParekh%2C+Ameeta%3BThomas%2C+Kimberly%3BAljuburi%2C+Lina%3BUhl%2C+Kathleen&rft.aulast=Pinnow&rft.aufirst=Ellen&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIOSH Brings Industry Sector Approach to Agriculture, Forestry and Fishing Safety and Health. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766348; 4782059 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Conway, George A AU - Husberg, Bradley J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Forestry KW - Fishing KW - Agriculture KW - Health and safety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=NIOSH+Brings+Industry+Sector+Approach+to+Agriculture%2C+Forestry+and+Fishing+Safety+and+Health.&rft.au=Conway%2C+George+A%3BHusberg%2C+Bradley+J&rft.aulast=Conway&rft.aufirst=George&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oil and Gas Exploration and Extraction Injury Deaths: A Re-Emerging Hazard. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766289; 4782023 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Conway, George A AU - Mode, Nicolle A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Oil and gas exploration KW - Mortality KW - Injuries KW - Hazards KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Oil+and+Gas+Exploration+and+Extraction+Injury+Deaths%3A+A+Re-Emerging+Hazard.&rft.au=Conway%2C+George+A%3BMode%2C+Nicolle+A&rft.aulast=Conway&rft.aufirst=George&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maternal and Child Health Initiatives in Sickle Cell Disease T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766209; 4780843 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lloyd-Puryear, Michele AU - Mann, Marie Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sickle cell disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Maternal+and+Child+Health+Initiatives+in+Sickle+Cell+Disease&rft.au=Lloyd-Puryear%2C+Michele%3BMann%2C+Marie&rft.aulast=Lloyd-Puryear&rft.aufirst=Michele&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Breast Pump use at Two, Five, and Seven Months Postpartum T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766164; 4781398 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Labiner-Wolfe, Judith AU - Wang, Cunlin AU - Fein, Sara B AU - Shealy, Katherine Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Pumps KW - Postpartum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Breast+Pump+use+at+Two%2C+Five%2C+and+Seven+Months+Postpartum&rft.au=Labiner-Wolfe%2C+Judith%3BWang%2C+Cunlin%3BFein%2C+Sara+B%3BShealy%2C+Katherine&rft.aulast=Labiner-Wolfe&rft.aufirst=Judith&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tri Community a and I Project T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766004; 4782416 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Gamble, Rick AU - Hickenbotham, Algia AU - Vassallo, Angela AU - Patterson, Pam Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Tri+Community+a+and+I+Project&rft.au=Gamble%2C+Rick%3BHickenbotham%2C+Algia%3BVassallo%2C+Angela%3BPatterson%2C+Pam&rft.aulast=Gamble&rft.aufirst=Rick&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trajectories of Criminal Justice Involvement among a State Mental Health Agency's Clientele: Findings from a 10-Year Cohort Study T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765905; 4783729 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fisher, William H AU - Banks, Steven M AU - Roy-Bujnowski, Kristen AU - Clayfield, Jonathan AU - Grudzinskas, Albert J AU - Wolff, Nancy Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Trajectories+of+Criminal+Justice+Involvement+among+a+State+Mental+Health+Agency%27s+Clientele%3A+Findings+from+a+10-Year+Cohort+Study&rft.au=Fisher%2C+William+H%3BBanks%2C+Steven+M%3BRoy-Bujnowski%2C+Kristen%3BClayfield%2C+Jonathan%3BGrudzinskas%2C+Albert+J%3BWolff%2C+Nancy&rft.aulast=Fisher&rft.aufirst=William&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Screening and Brief Intervention Program with Alaskan Natives: The Connections SBIRT Experience T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765770; 4780107 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Stegbauer, Thomas AU - Kleinschmidt, Erich AU - Sommer, Shannon AU - Naquin, Valerie AU - Trojan, Jodi AU - Cage, Brandi AU - Nelson, Travette AU - Brady, Thomas M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Intervention KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Screening+and+Brief+Intervention+Program+with+Alaskan+Natives%3A+The+Connections+SBIRT+Experience&rft.au=Stegbauer%2C+Thomas%3BKleinschmidt%2C+Erich%3BSommer%2C+Shannon%3BNaquin%2C+Valerie%3BTrojan%2C+Jodi%3BCage%2C+Brandi%3BNelson%2C+Travette%3BBrady%2C+Thomas+M&rft.aulast=Stegbauer&rft.aufirst=Thomas&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Community Based Participatory Approaches to Provide Genetics Education T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765684; 4782532 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Kyler, Panelpha AU - Puryear, Michele Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Genetics KW - Education KW - Community involvement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Using+Community+Based+Participatory+Approaches+to+Provide+Genetics+Education&rft.au=Kyler%2C+Panelpha%3BPuryear%2C+Michele&rft.aulast=Kyler&rft.aufirst=Panelpha&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Can the Vitamin D Needs of the North American Public be Met by Current Supplementation and Fortification Practices in the Absence of Sun Exposure? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765544; 4780258 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Calvo, Mona S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - North America KW - Vitamin D KW - Sun KW - Supplementation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Can+the+Vitamin+D+Needs+of+the+North+American+Public+be+Met+by+Current+Supplementation+and+Fortification+Practices+in+the+Absence+of+Sun+Exposure%3F&rft.au=Calvo%2C+Mona+S&rft.aulast=Calvo&rft.aufirst=Mona&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Smoking in the Home and Children's Health T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765350; 4780019 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hill, Steven C AU - Liang, Lan Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Smoking KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Smoking+in+the+Home+and+Children%27s+Health&rft.au=Hill%2C+Steven+C%3BLiang%2C+Lan&rft.aulast=Hill&rft.aufirst=Steven&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mental Health Issues and SAMHSA Resources T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765255; 4782476 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Power, A.Kathryn Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Mental+Health+Issues+and+SAMHSA+Resources&rft.au=Power%2C+A.Kathryn&rft.aulast=Power&rft.aufirst=A.Kathryn&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using the IHI-Model for Improvement and a Brief Encounter Education Format to Implement Best Practices in Long Term Care Settings T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764793; 4782644 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Bigley, Mary Beth AU - Simon, Lin Noyes AU - Lunsford, Beverly Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Education KW - Best practices KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Using+the+IHI-Model+for+Improvement+and+a+Brief+Encounter+Education+Format+to+Implement+Best+Practices+in+Long+Term+Care+Settings&rft.au=Bigley%2C+Mary+Beth%3BSimon%2C+Lin+Noyes%3BLunsford%2C+Beverly&rft.aulast=Bigley&rft.aufirst=Mary&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fall-Related Hospitalizations among Elderly Medicare Beneficiaries T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764713; 4782795 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Buczko, William Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Elderly KW - Geriatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Fall-Related+Hospitalizations+among+Elderly+Medicare+Beneficiaries&rft.au=Buczko%2C+William&rft.aulast=Buczko&rft.aufirst=William&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recent Developments in the National, Standardized, Publicly Reported Survey of Patients' Perspectives of Hospital Care (HCAHPS). T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764677; 4781990 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lehrman, William G AU - Goldstein, Elizabeth Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hospitals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Recent+Developments+in+the+National%2C+Standardized%2C+Publicly+Reported+Survey+of+Patients%27+Perspectives+of+Hospital+Care+%28HCAHPS%29.&rft.au=Lehrman%2C+William+G%3BGoldstein%2C+Elizabeth&rft.aulast=Lehrman&rft.aufirst=William&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bringing Science to Consumers: Designing Appropriate Health Education Materials T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764612; 4784147 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lemon, Alison Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Education KW - Consumers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Bringing+Science+to+Consumers%3A+Designing+Appropriate+Health+Education+Materials&rft.au=Lemon%2C+Alison&rft.aulast=Lemon&rft.aufirst=Alison&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender Differential in National Estimates for Medical Device-Associated Adverse Events from Emergency Departments T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764266; 4783206 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Wang, Cunlin AU - Hefflin, Brockton AU - Marinica-Dabic, Danic AU - Loyo-Berrios, Nilsa AU - Zhou, Jie Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sex KW - Emergencies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Gender+Differential+in+National+Estimates+for+Medical+Device-Associated+Adverse+Events+from+Emergency+Departments&rft.au=Wang%2C+Cunlin%3BHefflin%2C+Brockton%3BMarinica-Dabic%2C+Danic%3BLoyo-Berrios%2C+Nilsa%3BZhou%2C+Jie&rft.aulast=Wang&rft.aufirst=Cunlin&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using National Outcomes Data to Improve the Health of Seniors T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763947; 4782773 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Bowen, Sonya E AU - Haffer, Samuel C AU - Long, William Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Aging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Using+National+Outcomes+Data+to+Improve+the+Health+of+Seniors&rft.au=Bowen%2C+Sonya+E%3BHaffer%2C+Samuel+C%3BLong%2C+William&rft.aulast=Bowen&rft.aufirst=Sonya&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health and Safety for Home Healthcare Workers: Politics, Policy and Public Health for a Unique Worker Population T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763905; 4782766 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Gong, Fang AU - Baron, Sherry L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Politics KW - Public health KW - Medical personnel KW - Policies KW - Health and safety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Health+and+Safety+for+Home+Healthcare+Workers%3A+Politics%2C+Policy+and+Public+Health+for+a+Unique+Worker+Population&rft.au=Gong%2C+Fang%3BBaron%2C+Sherry+L&rft.aulast=Gong&rft.aufirst=Fang&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HRSA Funded Grantees Convened in a Strategic Process Intended to Enhance Funding Impact through Collaboration T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763886; 4783618 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Alos, Victor AU - Alston, Kenneth AU - Roberts, Alma AU - Williams, Jackie AU - Reed-Vance, Maxine Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=HRSA+Funded+Grantees+Convened+in+a+Strategic+Process+Intended+to+Enhance+Funding+Impact+through+Collaboration&rft.au=Alos%2C+Victor%3BAlston%2C+Kenneth%3BRoberts%2C+Alma%3BWilliams%2C+Jackie%3BReed-Vance%2C+Maxine&rft.aulast=Alos&rft.aufirst=Victor&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Hurricanes Katrina and Rita and their Aftermath on Substance use and Mental Illness T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763649; 4779944 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Colpe, Lisa J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mental disorders KW - Substance use KW - Hurricanes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Impact+of+Hurricanes+Katrina+and+Rita+and+their+Aftermath+on+Substance+use+and+Mental+Illness&rft.au=Colpe%2C+Lisa+J&rft.aulast=Colpe&rft.aufirst=Lisa&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disparities in Children's Health Care Quality: Findings from the 2006 National Healthcare Disparities Report T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763497; 4783298 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Ho, Karen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Health care KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+American+Thoracic+Society&rft.atitle=Gene-air+pollution+interactions+in+asthma.&rft.au=London%2C+Stephanie+J&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2007-07-01&rft.volume=4&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+American+Thoracic+Society&rft.issn=15463222&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infant Feeding Practices Study II: Methods and Sample Characteristics T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763471; 4783661 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fein, Sara B AU - Labiner-Wolfe, Judith AU - Shealy, Katherine AU - Grummer-Strawn, Laurence AU - Li, Ruowei Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Infants KW - Feeding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Infant+Feeding+Practices+Study+II%3A+Methods+and+Sample+Characteristics&rft.au=Fein%2C+Sara+B%3BLabiner-Wolfe%2C+Judith%3BShealy%2C+Katherine%3BGrummer-Strawn%2C+Laurence%3BLi%2C+Ruowei&rft.aulast=Fein&rft.aufirst=Sara&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Childrens' Pathways to Care T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763270; 4783228 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Pfefferle, Susan G AU - Spitznagel, Edward L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Childrens%27+Pathways+to+Care&rft.au=Pfefferle%2C+Susan+G%3BSpitznagel%2C+Edward+L&rft.aulast=Pfefferle&rft.aufirst=Susan&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - U.S./Vietnam Scientific Cooperation: Building Capacity to Evaluate Agent Orange/Dioxin Soil Contamination T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762816; 4783522 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sweeney, Marie Haring AU - Farland, William H Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Vietnam KW - 2,4,5-T KW - Soil pollution KW - Dioxin KW - Contamination KW - Agent Orange KW - Cooperation KW - Chlorinated hydrocarbons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=U.S.%2FVietnam+Scientific+Cooperation%3A+Building+Capacity+to+Evaluate+Agent+Orange%2FDioxin+Soil+Contamination&rft.au=Sweeney%2C+Marie+Haring%3BFarland%2C+William+H&rft.aulast=Sweeney&rft.aufirst=Marie&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lack of Planned Subgroup Analysis: Review of Drug Protocols Submitted to the Food and Drug Administration T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762701; 4783596 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sharma, Pellavi AU - Pinnow, Ellen AU - Scott, Pamela AU - Derbis, Janelle AU - Toigo, Theresa AU - Uhl, Kathleen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Drugs KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Lack+of+Planned+Subgroup+Analysis%3A+Review+of+Drug+Protocols+Submitted+to+the+Food+and+Drug+Administration&rft.au=Sharma%2C+Pellavi%3BPinnow%2C+Ellen%3BScott%2C+Pamela%3BDerbis%2C+Janelle%3BToigo%2C+Theresa%3BUhl%2C+Kathleen&rft.aulast=Sharma&rft.aufirst=Pellavi&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Morbidity and Mortality Associated with the Nonmedical use of Dextromethorphan T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762345; 4779946 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Crane, Elizabeth H AU - Poneleit, Kathy Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mortality KW - Morbidity KW - Dextromethorphan KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Morbidity+and+Mortality+Associated+with+the+Nonmedical+use+of+Dextromethorphan&rft.au=Crane%2C+Elizabeth+H%3BPoneleit%2C+Kathy&rft.aulast=Crane&rft.aufirst=Elizabeth&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Misuse of OTC Cold and Cough Medications: New Data from NSDUH T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762055; 4779945 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Colliver, James D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cough KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Misuse+of+OTC+Cold+and+Cough+Medications%3A+New+Data+from+NSDUH&rft.au=Colliver%2C+James+D&rft.aulast=Colliver&rft.aufirst=James&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epidemiology of Invasive Pneumococcal Disease in the Era of Childhood Vaccination: Newark, New Jersey T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40761986; 4781047 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sison, Erica J AU - Sinha, Anushua AU - Tasslimi, Azadeh AU - Leszczyniecka, Zofia AU - McGowan, Marsha AU - McHugh, Lisa A AU - Thomas, Polly AU - Wenger, Peter Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA, New Jersey KW - Children KW - Vaccination KW - Epidemiology KW - Streptococcus pneumoniae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Epidemiology+of+Invasive+Pneumococcal+Disease+in+the+Era+of+Childhood+Vaccination%3A+Newark%2C+New+Jersey&rft.au=Sison%2C+Erica+J%3BSinha%2C+Anushua%3BTasslimi%2C+Azadeh%3BLeszczyniecka%2C+Zofia%3BMcGowan%2C+Marsha%3BMcHugh%2C+Lisa+A%3BThomas%2C+Polly%3BWenger%2C+Peter&rft.aulast=Sison&rft.aufirst=Erica&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Planning for an Urban Community Health Survey - Insights from Focus Groups in Newark, NJ T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40761030; 4781114 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Springer, M AU - Thomas, P A AU - Edwards, D AU - McGowan, M AU - Passannante, M AU - Rosenblum, D M AU - Holland, B K AU - Houston, S AU - Brown, D R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Urban areas KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Planning+for+an+Urban+Community+Health+Survey+-+Insights+from+Focus+Groups+in+Newark%2C+NJ&rft.au=Springer%2C+M%3BThomas%2C+P+A%3BEdwards%2C+D%3BMcGowan%2C+M%3BPassannante%2C+M%3BRosenblum%2C+D+M%3BHolland%2C+B+K%3BHouston%2C+S%3BBrown%2C+D+R&rft.aulast=Springer&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - They're Either Prepared or They're Not! Prevalence and Risk Factors for the Presence of Carbon Monoxide Alarms in Maine Households T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760913; 4781062 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Graber, Judith M AU - Mittal, Prashant AU - Smith, Andrew E Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA, Maine KW - Carbon monoxide KW - Households KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=They%27re+Either+Prepared+or+They%27re+Not%21+Prevalence+and+Risk+Factors+for+the+Presence+of+Carbon+Monoxide+Alarms+in+Maine+Households&rft.au=Graber%2C+Judith+M%3BMittal%2C+Prashant%3BSmith%2C+Andrew+E&rft.aulast=Graber&rft.aufirst=Judith&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Current and Future Workforce Issues in Substance Abuse Prevention and Early Intervention in the Workplace T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760716; 4779912 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Galvin, Deborah AU - Schlenger, William AU - Karuntzos, Georgia AU - Bray, Jeremy Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - Intervention KW - Substance abuse KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Current+and+Future+Workforce+Issues+in+Substance+Abuse+Prevention+and+Early+Intervention+in+the+Workplace&rft.au=Galvin%2C+Deborah%3BSchlenger%2C+William%3BKaruntzos%2C+Georgia%3BBray%2C+Jeremy&rft.aulast=Galvin&rft.aufirst=Deborah&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Burn Casualty Preparedness: A Program Evaluation of the Burn Asset Resource Tracking System. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760258; 4781642 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hsu, Sophia AU - Lavin, Roberta AU - Borden, Cheryl Ann AU - Bardack, Stephanie Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Burns KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Burn+Casualty+Preparedness%3A+A+Program+Evaluation+of+the+Burn+Asset+Resource+Tracking+System.&rft.au=Hsu%2C+Sophia%3BLavin%2C+Roberta%3BBorden%2C+Cheryl+Ann%3BBardack%2C+Stephanie&rft.aulast=Hsu&rft.aufirst=Sophia&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Health Takes Priority with Head Start T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40759992; 4782856 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Rossetti, John AU - Goodman, Harry AU - Jackson, Beverly Roberson AU - Holt, Katrina A AU - Geurink, Kathy Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Head KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Oral+Health+Takes+Priority+with+Head+Start&rft.au=Rossetti%2C+John%3BGoodman%2C+Harry%3BJackson%2C+Beverly+Roberson%3BHolt%2C+Katrina+A%3BGeurink%2C+Kathy&rft.aulast=Rossetti&rft.aufirst=John&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Premigration Factors and Mental Health among Asian Immigrants T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40759476; 4782996 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Gong, Fang Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Immigrants KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Premigration+Factors+and+Mental+Health+among+Asian+Immigrants&rft.au=Gong%2C+Fang&rft.aulast=Gong&rft.aufirst=Fang&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Obesity in Newark Adults 18 Years and Older: Using State and National Data T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40759444; 4780948 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Springer, M AU - Thomas, P A AU - O'Dowd, K J AU - McGowan, M AU - Halperin, W E Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Obesity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Prevalence+of+Obesity+in+Newark+Adults+18+Years+and+Older%3A+Using+State+and+National+Data&rft.au=Springer%2C+M%3BThomas%2C+P+A%3BO%27Dowd%2C+K+J%3BMcGowan%2C+M%3BHalperin%2C+W+E&rft.aulast=Springer&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Refining Estimates of Public Health Spending as Measured in National Health Expenditures Accounts. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40758908; 4781582 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Sensenig, Arthur L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40758908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Refining+Estimates+of+Public+Health+Spending+as+Measured+in+National+Health+Expenditures+Accounts.&rft.au=Sensenig%2C+Arthur+L&rft.aulast=Sensenig&rft.aufirst=Arthur&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Survival Comparison between HIV Positive U.S. Born Hispanics and Foreign-Born Hispanics in Houston, Texas 1990 - 2001 T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40758552; 4780811 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Arafat, Raouf AU - Awosika-Olumo, Adebowale AU - Gomez, James AU - Wolverton, Marcia AU - Anderson, Lydwina Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA, Texas KW - USA, Texas, Houston KW - Ethnic groups KW - Human immunodeficiency virus KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40758552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Survival+Comparison+between+HIV+Positive+U.S.+Born+Hispanics+and+Foreign-Born+Hispanics+in+Houston%2C+Texas+1990+-+2001&rft.au=Arafat%2C+Raouf%3BAwosika-Olumo%2C+Adebowale%3BGomez%2C+James%3BWolverton%2C+Marcia%3BAnderson%2C+Lydwina&rft.aulast=Arafat&rft.aufirst=Raouf&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health Disparities among Aged Hispanic Medicare Beneficiaries: The Current Perspective T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757819; 4780889 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Greenberg, Linda G AU - Moy, Ernest AU - Borsky, Amanda E Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Ethnic groups KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Health+Disparities+among+Aged+Hispanic+Medicare+Beneficiaries%3A+The+Current+Perspective&rft.au=Greenberg%2C+Linda+G%3BMoy%2C+Ernest%3BBorsky%2C+Amanda+E&rft.aulast=Greenberg&rft.aufirst=Linda&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disparities in Chronic Disease Management and Prevention: Findings from the 2006 National Healthcare Disparities Report T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757785; 4780891 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Ho, Karen AU - Hines, Anika L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Disparities+in+Chronic+Disease+Management+and+Prevention%3A+Findings+from+the+2006+National+Healthcare+Disparities+Report&rft.au=Ho%2C+Karen%3BHines%2C+Anika+L&rft.aulast=Ho&rft.aufirst=Karen&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Occupation and Industry Data Collection in the NH State Cancer Registry (NHSCR) T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757753; 4781327 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Armenti, Karla R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Data collection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Evaluation+of+Occupation+and+Industry+Data+Collection+in+the+NH+State+Cancer+Registry+%28NHSCR%29&rft.au=Armenti%2C+Karla+R&rft.aulast=Armenti&rft.aufirst=Karla&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Re-Injury on Military Discharge from the US Army. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757745; 4781770 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Tiesman, Hope AU - Peek-Asa, Corinne AU - Zwerling, Craig AU - Whitten, Paul AU - Amoroso, Paul J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Military KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Effects+of+Re-Injury+on+Military+Discharge+from+the+US+Army.&rft.au=Tiesman%2C+Hope%3BPeek-Asa%2C+Corinne%3BZwerling%2C+Craig%3BWhitten%2C+Paul%3BAmoroso%2C+Paul+J&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do U.S. Consumers Know the Differences between Fats and their Relationships with Heart Disease. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757274; 4781874 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lin, Chung-Tung Jordan AU - Yen, Steven T Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Heart diseases KW - Consumers KW - Fats KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Do+U.S.+Consumers+Know+the+Differences+between+Fats+and+their+Relationships+with+Heart+Disease.&rft.au=Lin%2C+Chung-Tung+Jordan%3BYen%2C+Steven+T&rft.aulast=Lin&rft.aufirst=Chung-Tung&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender Differences in Occupational and Non-Occupational Injuries in the U.S. Army. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757089; 4781769 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Tiesman, Hope AU - Peek-Asa, Corinne AU - Zwerling, Craig AU - Yang, Jingzhen AU - Amoroso, Paul J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Sex KW - Injuries KW - Sex differences KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Gender+Differences+in+Occupational+and+Non-Occupational+Injuries+in+the+U.S.+Army.&rft.au=Tiesman%2C+Hope%3BPeek-Asa%2C+Corinne%3BZwerling%2C+Craig%3BYang%2C+Jingzhen%3BAmoroso%2C+Paul+J&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Illicit Drug use and Health Conditions: Results from the 2005 and 2006 National Survey on Drug use and Health T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40757059; 4779911 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Han, Beth AU - Colliver, James AU - Gfroerer, Joe Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Relationship+between+Illicit+Drug+use+and+Health+Conditions%3A+Results+from+the+2005+and+2006+National+Survey+on+Drug+use+and+Health&rft.au=Han%2C+Beth%3BColliver%2C+James%3BGfroerer%2C+Joe&rft.aulast=Han&rft.aufirst=Beth&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interdependence of Mental Health, Physical Health and Health Risk from the Maine BRFSS T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40756629; 4781188 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Freeman, Elsie AU - Neale, Kip AU - Yoe, James Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA, Maine KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40756629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Interdependence+of+Mental+Health%2C+Physical+Health+and+Health+Risk+from+the+Maine+BRFSS&rft.au=Freeman%2C+Elsie%3BNeale%2C+Kip%3BYoe%2C+James&rft.aulast=Freeman&rft.aufirst=Elsie&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Community-Based Survey Methods and Knowledge T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40755602; 4780719 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Manning, Thomas L AU - Seschillie, Bess K AU - Elwood, Jerry AU - Norton, Bernice Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Community involvement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40755602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Community-Based+Survey+Methods+and+Knowledge&rft.au=Manning%2C+Thomas+L%3BSeschillie%2C+Bess+K%3BElwood%2C+Jerry%3BNorton%2C+Bernice&rft.aulast=Manning&rft.aufirst=Thomas&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Autism Spectrum Disorders in Medicaid and Associated Health Care Utilization T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40754738; 4781301 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Anderson, Karyn Kai AU - Mandell, David S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Health care KW - Autism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Prevalence+of+Autism+Spectrum+Disorders+in+Medicaid+and+Associated+Health+Care+Utilization&rft.au=Anderson%2C+Karyn+Kai%3BMandell%2C+David+S&rft.aulast=Anderson&rft.aufirst=Karyn&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial and Ethnic Minority Primary Care Providers: Improving Access and Patient-Provider Communication T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40754411; 4781322 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Moy, Ernest AU - Hogan, Sara Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Communication KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Racial+and+Ethnic+Minority+Primary+Care+Providers%3A+Improving+Access+and+Patient-Provider+Communication&rft.au=Moy%2C+Ernest%3BHogan%2C+Sara&rft.aulast=Moy&rft.aufirst=Ernest&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Morris Water Maze Performance of Adult Rats Appears Insensitive to Lifetime Acrylamide Treatment T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39622795; 4711321 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Smith, M E AU - Paule, M G AU - Garey, J D AU - Ferguson, S A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Rats KW - Acrylamide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Morris+Water+Maze+Performance+of+Adult+Rats+Appears+Insensitive+to+Lifetime+Acrylamide+Treatment&rft.au=Smith%2C+M+E%3BPaule%2C+M+G%3BGarey%2C+J+D%3BFerguson%2C+S+A&rft.aulast=Smith&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Chronic Stress Regimen with Unpredictable Stressor Presentation Decreases the Density of Spines on the CA3 Pyramidal Neurons of the Hippocampus in the Adult C57BL/6J Male Mouse T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39619968; 4718872 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Miller, D B AU - Bachstetter, A D AU - Mervis, R J AU - Benkovic, S A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Stress KW - Spine KW - Pyramidal cells KW - Hippocampus KW - Spines KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39619968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Chronic+Stress+Regimen+with+Unpredictable+Stressor+Presentation+Decreases+the+Density+of+Spines+on+the+CA3+Pyramidal+Neurons+of+the+Hippocampus+in+the+Adult+C57BL%2F6J+Male+Mouse&rft.au=Miller%2C+D+B%3BBachstetter%2C+A+D%3BMervis%2C+R+J%3BBenkovic%2C+S+A&rft.aulast=Miller&rft.aufirst=D&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Phencyclidine or Ketamine Treatment Significantly Slows Body Weight Gain and Alters Early Preweaning Behaviors in Sprague-Dawley Rats T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39598072; 4717302 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Boctor, S Y AU - Sadovova, N AU - Zou, X AU - Wang, C AU - Ferguson, S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Body weight KW - Rats KW - Body weight gain KW - Phencyclidine KW - Ketamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39598072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Developmental+Phencyclidine+or+Ketamine+Treatment+Significantly+Slows+Body+Weight+Gain+and+Alters+Early+Preweaning+Behaviors+in+Sprague-Dawley+Rats&rft.au=Boctor%2C+S+Y%3BSadovova%2C+N%3BZou%2C+X%3BWang%2C+C%3BFerguson%2C+S&rft.aulast=Boctor&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Exogenous Activation of Proteinase-activated Receptors in the Capsaicin Induced Central Sensitization of Rats T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39572016; 4706563 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Zhang, X AU - Lei, Y AU - Fang, L AU - Willis, W D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Rats KW - Capsaicin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39572016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Effects+of+Exogenous+Activation+of+Proteinase-activated+Receptors+in+the+Capsaicin+Induced+Central+Sensitization+of+Rats&rft.au=Zhang%2C+X%3BLei%2C+Y%3BFang%2C+L%3BWillis%2C+W+D&rft.aulast=Zhang&rft.aufirst=X&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sodium Titanate Nanowires: Fabrication and Interaction with PC-12 Cells T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39567421; 4711953 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Ali, H K AU - Padilla, C S AU - Tian, R AU - Duhart, H L AU - Ali, S F AU - Patterson, T A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39567421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sodium+Titanate+Nanowires%3A+Fabrication+and+Interaction+with+PC-12+Cells&rft.au=Ali%2C+H+K%3BPadilla%2C+C+S%3BTian%2C+R%3BDuhart%2C+H+L%3BAli%2C+S+F%3BPatterson%2C+T+A&rft.aulast=Ali&rft.aufirst=H&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Acrylamide and Acetyl-L-carnitine on Motor Nerve Conduction Velocity and Grip Strength in Adult Rats T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39563333; 4710011 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Garey, J D AU - Beaudoin, M A AU - Paule, M G AU - Skinner, R D AU - Binienda, Z K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Velocity KW - Rats KW - Acrylamide KW - Acetyl-L-carnitine KW - Nerve conduction KW - Nerves KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39563333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Acrylamide+and+Acetyl-L-carnitine+on+Motor+Nerve+Conduction+Velocity+and+Grip+Strength+in+Adult+Rats&rft.au=Garey%2C+J+D%3BBeaudoin%2C+M+A%3BPaule%2C+M+G%3BSkinner%2C+R+D%3BBinienda%2C+Z+K&rft.aulast=Garey&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Supraphysiological Levels of Corticosterone Attenuate Glial Activation and Provide Protection Against Excitotoxicity T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39560358; 4706160 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Benkovic, S A AU - O'callaghan, J P AU - Miller, D B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Excitotoxicity KW - Corticosterone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39560358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Supraphysiological+Levels+of+Corticosterone+Attenuate+Glial+Activation+and+Provide+Protection+Against+Excitotoxicity&rft.au=Benkovic%2C+S+A%3BO%27callaghan%2C+J+P%3BMiller%2C+D+B&rft.aulast=Benkovic&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Methamphetamine Dysregulates Astrocytes Functions, Increasing Oxidative Stress T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39536584; 4716810 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Ali, S F AU - Jiang, H AU - Rongzhu, L AU - Milatovic, D AU - Aschner, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Oxidative stress KW - Methamphetamine KW - Astrocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39536584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Methamphetamine+Dysregulates+Astrocytes+Functions%2C+Increasing+Oxidative+Stress&rft.au=Ali%2C+S+F%3BJiang%2C+H%3BRongzhu%2C+L%3BMilatovic%2C+D%3BAschner%2C+M&rft.aulast=Ali&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Time Course of the Scavenging of Axons in Caudate/Putamen after a Neurotoxic Amphetamine Exposure Indicates Many are of Thalamic Origin T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39530415; 4711920 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Bowyer, J F AU - Schmued, L C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Neurotoxicity KW - Putamen KW - Amphetamine KW - Thalamus KW - Axons KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39530415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Time+Course+of+the+Scavenging+of+Axons+in+Caudate%2FPutamen+after+a+Neurotoxic+Amphetamine+Exposure+Indicates+Many+are+of+Thalamic+Origin&rft.au=Bowyer%2C+J+F%3BSchmued%2C+L+C&rft.aulast=Bowyer&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of the JAK-STAT3 Pathway is Associated with the Induction of Astrogliosis in Multiple Models of Neurotoxicity T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39515255; 4713320 JF - 2007 Annual Meeting of the Society for Neuroscience AU - O'callaghan, J P AU - Sriram, K AU - Benkovic, S A AU - Miller, D B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Neurotoxicity KW - Gliosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39515255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activation+of+the+JAK-STAT3+Pathway+is+Associated+with+the+Induction+of+Astrogliosis+in+Multiple+Models+of+Neurotoxicity&rft.au=O%27callaghan%2C+J+P%3BSriram%2C+K%3BBenkovic%2C+S+A%3BMiller%2C+D+B&rft.aulast=O%27callaghan&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Evaluation of Bone and Mineral Metabolism in Patients Recently Diagnosed With Leprosy AN - 746010624; 13136920 AB - This study was conducted to evaluate patients recently diagnosed with the tuberculoid and lepromatous forms of leprosy for bone mass, bone remodeling, and hormones related to mineral control. Eleven normal control individuals (CG) and 12 patients with leprosy (LG) matched for physical characteristics were submitted to evaluation of bone mass density (BMD) and to the determination of serum levels of PTH, 25-hydroxyvitamin D [25(OH)D], testosterone, LH, FSH, osteocalcin (OC), and urinary levels of deoxypyridinoline (DPD). The T score of lumbar spine and total radius (mean c SD) were significantly lower in leprosy patients (L1-L4: CG = -0.7 c 1.5 vs LG = -1.8 c 1.0 SD, P < 0.04, and total radius: CG = -1.43 c 0.6 vs LG = -2.1 c 0.8 SD, P < 0.02), whereas no significant differences were observed in total hip or femoral neck T score. However, at all sites, the rate of low bone mass (T score < -1.0) was higher in LG (femoral neck: CG = 18% vs LG = 50%, total hip: CG = 27% vs LG = 42%). There was a significant difference in albumin and PTH levels between groups but not in serum 25(OH)D and OC levels or urinary DPD levels. The present results indicate that bone mass loss is an early event in leprosy patients and frequently is already present at diagnosis. Its etiopathogenesis is multifactorial, and further studies are needed to determine the most efficient way to prevent fractures in this condition. The data obtained in the present study need confirmation by the evaluation of a larger sample. JF - American Journal of the Medical Sciences AU - Ribeiro, F B AU - Pereira, FDA AU - Muller, E AU - Foss, N T AU - de Paula, FJA Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 322 EP - 326 VL - 334 IS - 5 SN - 0002-9629, 0002-9629 KW - Microbiology Abstracts B: Bacteriology; Calcium & Calcified Tissue Abstracts KW - Physical characteristics KW - Data processing KW - Follicle-stimulating hormone KW - Osteocalcin KW - Fractures KW - 25-Hydroxyvitamin D KW - Hormones KW - Femur KW - Leprosy KW - Serum levels KW - Spine (lumbar) KW - Testosterone KW - Bone mineral density KW - Radius KW - Luteinizing hormone KW - Albumin KW - Parathyroid hormone KW - Bone mass KW - Bone remodelling KW - deoxypyridinoline KW - Metabolism KW - Hip KW - J 02400:Human Diseases KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746010624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+the+Medical+Sciences&rft.atitle=Evaluation+of+Bone+and+Mineral+Metabolism+in+Patients+Recently+Diagnosed+With+Leprosy&rft.au=Ribeiro%2C+F+B%3BPereira%2C+FDA%3BMuller%2C+E%3BFoss%2C+N+T%3Bde+Paula%2C+FJA&rft.aulast=Ribeiro&rft.aufirst=F&rft.date=2007-11-01&rft.volume=334&rft.issue=5&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+the+Medical+Sciences&rft.issn=00029629&rft_id=info:doi/10.1097%2FMAJ.0b013e318142bafb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Physical characteristics; Follicle-stimulating hormone; Data processing; Osteocalcin; 25-Hydroxyvitamin D; Fractures; Femur; Hormones; Leprosy; Serum levels; Spine (lumbar); Testosterone; Bone mineral density; Radius; Luteinizing hormone; Albumin; Parathyroid hormone; Bone mass; Bone remodelling; deoxypyridinoline; Metabolism; Hip DO - http://dx.doi.org/10.1097/MAJ.0b013e318142bafb ER - TY - JOUR T1 - Gaussian representation of high-intensity focused ultrasound beams. AN - 742780707; pmid-18189543 AB - A method for fast numerical simulation of high-intensity focused ultrasound beams is derived. The method is based on the frequency-domain representation of the Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation, and assumes for each harmonic a Gaussian transverse pressure distribution at all distances from the transducer face. The beamwidths of the harmonics are constrained to vary inversely with the square root of the harmonic number, and as such this method may be viewed as an extension of a quasilinear approximation. The technique is capable of determining pressure or intensity fields of moderately nonlinear high-intensity focused ultrasound beams in water or biological tissue, usually requiring less than a minute of computer time on a modern workstation. Moreover, this method is particularly well suited to high-gain simulations since, unlike traditional finite-difference methods, it is not subject to resolution limitations in the transverse direction. Results are shown to be in reasonable agreement with numerical solutions of the full KZK equation in both tissue and water for moderately nonlinear beams. JF - The Journal of the Acoustical Society of America AU - Soneson, Joshua E AU - Myers, Matthew R AD - Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. joshua.soneson@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2526 EP - 2531 VL - 122 IS - 5 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Computer Simulation KW - Humans KW - Algorithms KW - Normal Distribution KW - Ultrasonic Therapy KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742780707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Gaussian+representation+of+high-intensity+focused+ultrasound+beams.&rft.au=Soneson%2C+Joshua+E%3BMyers%2C+Matthew+R&rft.aulast=Soneson&rft.aufirst=Joshua&rft.date=2007-11-01&rft.volume=122&rft.issue=5&rft.spage=2526&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - A method to quantify hand-transmitted vibration exposure based on the biodynamic stress concept. AN - 69086657; 18161245 AB - This study generally hypothesized that the vibration-induced biodynamic stress and number of its cycles in a substructure of the hand-arm system play an important role in the development of vibration-induced disorders in the substructure. As the first step to test this hypothesis, the specific aims of this study were to develop a practical method to quantify the biodynamic stress-cycle measure, to compare it with ISO-weighted and unweighted accelerations, and to assess its potential for applications. A mechanical-equivalent model of the system was established using reported experimental data. The model was used to estimate the average stresses in the fingers and palm. The frequency weightings of the stresses in these substructures were derived using the proposed stress-cycle measure. This study found the frequency dependence of the average stress distributed in the fingers is different from that in the palm. Therefore, this study predicted that the frequency dependencies of finger disorders could also be different from those of the disorders in the palm, wrist, and arms. If vibration-induced white finger (VWF) is correlated better with unweighted acceleration than with ISO-weighted acceleration, the biodynamic stress distributed in the fingers is likely to play a more important role in the development of VWF than is th e biodynamic stressdistributed in the other substructures of the hand-arm system. The results of this study also suggest that the ISO weighting underestimates the high-frequency effect on the finger disorder development but it may provide a reasonable risk assessment of the disorders in the wrist and arm. JF - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine AU - Dong, R G AU - Welcome, D E AU - Wu, J Z AD - Engineering and Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop L-2027, Morgantown, WV 26505, USA. rkd6@cdc.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 847 EP - 861 VL - 221 IS - 8 SN - 0954-4119, 0954-4119 KW - Index Medicus KW - Hand-Arm Vibration Syndrome -- physiopathology KW - Computer Simulation KW - Vibration KW - Stress, Mechanical KW - Humans KW - Energy Transfer -- physiology KW - Hand -- physiology KW - Movement -- physiology KW - Environmental Exposure -- analysis KW - Models, Biological KW - Biomechanical Phenomena -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Institution+of+Mechanical+Engineers.+Part+H%2C+Journal+of+engineering+in+medicine&rft.atitle=A+method+to+quantify+hand-transmitted+vibration+exposure+based+on+the+biodynamic+stress+concept.&rft.au=Dong%2C+R+G%3BWelcome%2C+D+E%3BWu%2C+J+Z&rft.aulast=Dong&rft.aufirst=R&rft.date=2007-11-01&rft.volume=221&rft.issue=8&rft.spage=847&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Institution+of+Mechanical+Engineers.+Part+H%2C+Journal+of+engineering+in+medicine&rft.issn=09544119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-22 N1 - Date created - 2007-12-28 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Liposomal doxorubicin in combination with bortezomib for relapsed or refractory multiple myeloma. AN - 69062390; 18077994 AB - On May 17, 2007, doxorubicin HCl liposome injection (Doxil) in combination with bortezomib (Velcade) received approval from the US Food and Drug Administration (FDA) for the treatment of relapsed or refractory multiple myeloma after at least one prior therapy that has not included bortezomib. Liposomal doxorubicin's efficacy and safety were demonstrated in a phase III, randomized, multicenter, international trial comparing the combination of this agent plus bortezomib vs bortezomib alone in multiple myeloma patients who had not previously received bortezomib and had received at least one prior therapy. Here we summarize the FDA review of the data that support this approval. An interim analysis of time to disease progression (TTP), the primary endpoint, was conducted after 249 TTP events in this study that randomized 324 patients to liposomal doxorubicin plus bortezomib treatment and 322 patients to bortezomib monotherapy. Time to progression was significantly prolonged in the combination arm (median TTP = 9.3 months) compared with bortezomib monotherapy (median TTP = 6.5 months), P < .0001 (log-rank test); hazard ratio = 0.55 (95% confidence interval = 0.43-0.71). The response rates were similar between the two arms and not statistically different; however, among responding patients, the median duration of response was longer with the combination--10.2 months compared to 7.0 months in the monotherapy arm. Adverse reactions occurred more frequently with the combination therapy. As compared to the monotherapy, frequent grade 3/4 adverse reactions with the combination were neutropenia and thrombocytopenia. Liposomal doxorubicin received FDA approval for use in combination with bortezomib in patients with multiple myeloma who have not previously received bortezomib and have received at least one prior therapy. JF - Oncology (Williston Park, N.Y.) AU - Ning, Yang-Min AU - He, Kun AU - Dagher, Ramzi AU - Sridhara, Rajeshwari AU - Farrell, Ann T AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration Silver Spring, Maryland 20993-0004, USA. ningy@cder.fda.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1503 EP - 8; discussion 1511, 1513, 1516 passim VL - 21 IS - 12 SN - 0890-9091, 0890-9091 KW - Antibiotics, Antineoplastic KW - 0 KW - Boronic Acids KW - Pyrazines KW - Bortezomib KW - 69G8BD63PP KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - United States KW - Humans KW - Salvage Therapy KW - Disease Progression KW - Aged KW - Kaplan-Meier Estimate KW - Aged, 80 and over KW - Drug Approval KW - Adult KW - Middle Aged KW - Female KW - Male KW - Doxorubicin -- adverse effects KW - Neoplasm Recurrence, Local -- drug therapy KW - Pyrazines -- therapeutic use KW - Multiple Myeloma -- drug therapy KW - Doxorubicin -- therapeutic use KW - Boronic Acids -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Boronic Acids -- therapeutic use KW - Pyrazines -- adverse effects KW - Antibiotics, Antineoplastic -- adverse effects KW - Antibiotics, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69062390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+%28Williston+Park%2C+N.Y.%29&rft.atitle=Liposomal+doxorubicin+in+combination+with+bortezomib+for+relapsed+or+refractory+multiple+myeloma.&rft.au=Ning%2C+Yang-Min%3BHe%2C+Kun%3BDagher%2C+Ramzi%3BSridhara%2C+Rajeshwari%3BFarrell%2C+Ann+T%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Ning&rft.aufirst=Yang-Min&rft.date=2007-11-01&rft.volume=21&rft.issue=12&rft.spage=1503&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Williston+Park%2C+N.Y.%29&rft.issn=08909091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2007-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Noise exposures during potato processing and manufacture of animal feed. AN - 69059213; 18075013 AB - A noise exposure survey was conducted at an agricultural facility to evaluate noise exposures during potato processing and during the manufacture of alfalfa pellets. Of the 19 employees monitored, five reached or exceeded the National Institute for Occupational Safety and Health recommended exposure limit for occupational noise. Four of these employees were from the potato processing area, and one was from the alfalfa pellet-mill operation. Two of the five (bagger and pellet-mill operator) also exceeded the Occupational Safety and Health Administration action level. The facility has a well-managed hearing conservation program for employees in the potato processing area, but not in the alfalfa manufacturing area. JF - Journal of agricultural safety and health AU - Achutan, C AU - Tubbs, R L AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. cma4@cdc.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 367 EP - 374 VL - 13 IS - 4 SN - 1074-7583, 1074-7583 KW - Index Medicus KW - Occupational Exposure KW - Animals KW - Ear Protective Devices KW - Solanum tuberosum KW - Humans KW - Medicago sativa KW - Animal Feed KW - Hearing Loss, Noise-Induced -- etiology KW - Agricultural Workers' Diseases -- prevention & control KW - Agricultural Workers' Diseases -- etiology KW - Hearing Loss, Noise-Induced -- prevention & control KW - Noise, Occupational -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69059213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+safety+and+health&rft.atitle=Noise+exposures+during+potato+processing+and+manufacture+of+animal+feed.&rft.au=Achutan%2C+C%3BTubbs%2C+R+L&rft.aulast=Achutan&rft.aufirst=C&rft.date=2007-11-01&rft.volume=13&rft.issue=4&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+safety+and+health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-12-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Agric Saf Health. 2008 Jan;14(1):table of contents N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats. AN - 68562892; 18047727 AB - Pyrrolizidine alkaloids (PAs) are probably the most common plant constituents that poison livestock, wildlife, and humans worldwide. Riddelliine is isolated from plants grown in the western United States and is a prototype of genotoxic PAs. Riddelliine was used to investigate the genotoxic effects of PAs via analysis of gene expression in the target tissue of rats in this study. Previously we observed that the mutant frequency in the liver of rats gavaged with riddelliine was 3-fold higher than that in the control group. Molecular analysis of the mutants indicated that there was a statistically significant difference between the mutational spectra from riddelliine-treated and control rats. Riddelliine-induced gene expression profiles in livers of Big Blue transgenic rats were determined. The female rats were gavaged with riddelliine at a dose of 1 mg/kg body weight 5 days a week for 12 weeks. Rat whole genome microarray was used to perform genome-wide gene expression studies. When a cutoff value of a two-fold change and a P-value less than 0.01 were used as gene selection criteria, 919 genes were identified as differentially expressed in riddelliine-treated rats compared to the control animals. By analysis with the Ingenuity Pathway Analysis Network, we found that these significantly changed genes were mainly involved in cancer, cell death, tissue development, cellular movement, tissue morphology, cell-to-cell signaling and interaction, and cellular growth and proliferation. We further analyzed the genes involved in metabolism, injury of endothelial cells, liver abnormalities, and cancer development in detail. The alterations in gene expression were directly related to the pathological outcomes reported previously. These results provided further insight into the mechanisms involved in toxicity and carcinogenesis after exposure to riddelliine, and permitted us to investigate the interaction of gene products inside the signaling networks. JF - BMC bioinformatics AU - Mei, Nan AU - Guo, Lei AU - Liu, Ruqing AU - Fuscoe, James C AU - Chen, Tao AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. nan.mei@fda.hhs.gov Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 1 VL - 8 Suppl 7 KW - Carcinogens KW - 0 KW - Proteome KW - Pyrrolizidine Alkaloids KW - riddelliine KW - 23246-96-0 KW - Index Medicus KW - Rats KW - Animals KW - Carcinogens -- administration & dosage KW - Carcinogenicity Tests KW - Liver -- drug effects KW - Signal Transduction -- drug effects KW - Proteome -- metabolism KW - Liver -- metabolism KW - Gene Expression Regulation -- drug effects KW - Pyrrolizidine Alkaloids -- toxicity KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68562892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+bioinformatics&rft.atitle=Gene+expression+changes+induced+by+the+tumorigenic+pyrrolizidine+alkaloid+riddelliine+in+liver+of+Big+Blue+rats.&rft.au=Mei%2C+Nan%3BGuo%2C+Lei%3BLiu%2C+Ruqing%3BFuscoe%2C+James+C%3BChen%2C+Tao&rft.aulast=Mei&rft.aufirst=Nan&rft.date=2007-11-01&rft.volume=8+Suppl+7&rft.issue=&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=BMC+bioinformatics&rft.issn=1471-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-29 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMC Bioinformatics. 2006;7 Suppl 2:S16 [17118137] Nat Genet. 2004 Sep;36(9):969-77 [15322543] Cancer Lett. 2004 Nov 25;215(2):151-8 [15488633] Carcinogenesis. 1991 Mar;12(3):515-9 [2009596] Toxicon. 1994 Aug;32(8):891-908 [7985194] Immunol Lett. 2005 Jan 31;96(2):155-62 [15585319] Carcinogenesis. 2005 Mar;26(3):689-99 [15618236] Cancer Lett. 2005 Aug 8;226(1):27-35 [16004930] Antioxid Redox Signal. 2005 Sep-Oct;7(9-10):1346-55 [16115040] Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2480-7 [16141406] Cancer Lett. 2006 Jan 8;231(1):138-45 [16356839] Gene. 2006 Jan 17;366(1):128-44 [16337094] Exp Biol Med (Maywood). 2006 Oct;231(9):1555-63 [17018880] Nat Biotechnol. 2006 Sep;24(9):1162-9 [17061323] Exp Clin Endocrinol Diabetes. 2006 Nov;114(10):584-9 [17177141] Cancer Lett. 2007 Aug 8;253(1):138-43 [17324501] BMC Bioinformatics. 2006;7 Suppl 2:S20 [17118142] Exp Mol Pathol. 2000 Aug;69(1):17-26 [10891289] Free Radic Biol Med. 2000 Aug;29(3-4):254-62 [11035254] Chem Res Toxicol. 2001 Jan;14(1):91-100 [11170512] Chem Res Toxicol. 2001 Jan;14(1):101-9 [11170513] Clin Cancer Res. 2002 Mar;8(3):636-40 [11895890] Int J Toxicol. 2002 Jan-Feb;21(1):7-12 [11936902] Toxicol Appl Pharmacol. 2002 Jul 15;182(2):98-104 [12140173] Chem Res Toxicol. 2003 Jan;16(1):66-73 [12693032] Cancer Lett. 2003 Apr 25;193(2):119-25 [12706867] Natl Toxicol Program Tech Rep Ser. 2003 May;(508):1-280 [12844193] Trends Biochem Sci. 2003 Jul;28(7):377-83 [12878005] Toxicol Lett. 2003 Oct 15;144(3):295-311 [12927348] Chem Res Toxicol. 2003 Sep;16(9):1130-7 [12971801] Horm Res. 2003;60(4):174-80 [14530605] Toxicol Lett. 2003 Dec 10;145(3):239-47 [14580895] Environ Health Perspect. 2003 Nov;111(15):1819-26 [14630514] Mutat Res. 2003 Dec 10;533(1-2):201-9 [14643421] Life Sci. 2004 Jan 9;74(8):935-68 [14672753] Front Biosci. 2004 Jan 1;9:139-44 [14766353] Drug Metab Rev. 2004 Feb;36(1):1-55 [15072438] Chem Res Toxicol. 2004 Jun;17(6):814-8 [15206902] Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1640-5 [15178563] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver. AN - 68561499; 18047722 AB - Comfrey (Symphytum officinale) is a perennial plant and has been consumed by humans as a vegetable, a tea and an herbal medicine for more than 2000 years. It, however, is hepatotoxic and carcinogenic in experimental animals and hepatotoxic in humans. Pyrrolizidine alkaloids (PAs) exist in many plants and many of them cause liver toxicity and/or cancer in humans and experimental animals. In our previous study, we found that the mutagenicity of comfrey was associated with the PAs contained in the plant. Therefore, we suggest that carcinogenicity of comfrey result from those PAs. To confirm our hypothesis, we compared the expression of genes and processes of biological functions that were altered by comfrey (mixture of the plant with PAs) and riddelliine (a prototype of carcinogenic PA) in rat liver for carcinogenesis in this study. Groups of 6 Big Blue Fisher 344 rats were treated with riddelliine at 1 mg/kg body weight by gavage five times a week for 12 weeks or fed a diet containing 8% comfrey root for 12 weeks. Animals were sacrificed one day after the last treatment and the livers were isolated for gene expression analysis. The gene expressions were investigated using Applied Biosystems Rat Whole Genome Survey Microarrays and the biological functions were analyzed with Ingenuity Analysis Pathway software. Although there were large differences between the significant genes and between the biological processes that were altered by comfrey and riddelliine, there were a number of common genes and function processes that were related to carcinogenesis. There was a strong correlation between the two treatments for fold-change alterations in expression of drug metabolizing and cancer-related genes. Our results suggest that the carcinogenesis-related gene expression patterns resulting from the treatments of comfrey and riddelliine are very similar, and PAs contained in comfrey are the main active components responsible for carcinogenicity of the plant. JF - BMC bioinformatics AU - Guo, Lei AU - Mei, Nan AU - Dial, Stacey AU - Fuscoe, James AU - Chen, Tao AD - Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. lei.guo@fda.hhs.gov Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 1 VL - 8 Suppl 7 KW - Carcinogens KW - 0 KW - Proteome KW - Pyrrolizidine Alkaloids KW - riddelliine KW - 23246-96-0 KW - Index Medicus KW - Rats KW - Animals KW - Carcinogens -- administration & dosage KW - Carcinogenicity Tests KW - Liver -- drug effects KW - Comfrey -- toxicity KW - Signal Transduction -- drug effects KW - Proteome -- metabolism KW - Liver -- metabolism KW - Gene Expression Regulation -- drug effects KW - Pyrrolizidine Alkaloids -- toxicity KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68561499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+bioinformatics&rft.atitle=Comparison+of+gene+expression+profiles+altered+by+comfrey+and+riddelliine+in+rat+liver.&rft.au=Guo%2C+Lei%3BMei%2C+Nan%3BDial%2C+Stacey%3BFuscoe%2C+James%3BChen%2C+Tao&rft.aulast=Guo&rft.aufirst=Lei&rft.date=2007-11-01&rft.volume=8+Suppl+7&rft.issue=&rft.spage=S22&rft.isbn=&rft.btitle=&rft.title=BMC+bioinformatics&rft.issn=1471-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-29 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Death Differ. 2007 Mar;14(3):436-46 [16990849] J Natl Cancer Inst. 1981 Jun;66(6):1037-52 [6941039] Br Med J (Clin Res Ed). 1987 Jul 18;295(6591):183 [3115370] Drug Metab Dispos. 1989 Jul-Aug;17(4):380-6 [2571476] Toxicol Lett. 1990 May;51(3):321-9 [2111054] J Gastroenterol Hepatol. 1990 Mar-Apr;5(2):211-4 [2103401] Proc Soc Exp Biol Med. 1993 Jan;202(1):1-8 [8424089] Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10914-21 [7902574] Toxicon. 1994 Aug;32(8):891-908 [7985194] Biochem Pharmacol. 1996 Feb 9;51(3):375-9 [8573205] Mol Cell Biol. 1997 Sep;17(9):5317-27 [9271409] Drug Metab Dispos. 1998 Feb;26(2):181-4 [9456306] Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3928-33 [10097140] Mutat Res. 1999 Jul 15;443(1-2):53-67 [10415431] Br J Cancer. 2005 Mar 14;92(5):873-5 [15726100] Toxicol Sci. 2005 Jul;86(1):185-93 [15814895] Environ Health Perspect. 2006 Jan;114(1):4-9 [16393650] Nature. 2007 Mar 8;446(7132):153-8 [17344846] BMC Bioinformatics. 2007;8 Suppl 7:S4 [18047727] BMC Bioinformatics. 2006;7 Suppl 2:S16 [17118137] Biochim Biophys Acta. 1999 Dec 6;1473(1):21-34 [10580127] Nat Med. 2000 Mar;6(3):306-12 [10700233] Chem Res Toxicol. 2001 Jan;14(1):91-100 [11170512] Chem Res Toxicol. 2001 Jan;14(1):101-9 [11170513] Public Health Nutr. 2000 Dec;3(4A):501-8 [11276298] Cancer Res. 2001 Apr 15;61(8):3230-9 [11309271] J Nat Prod. 2001 Feb;64(2):251-3 [11430014] Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10374-9 [11504921] Trends Pharmacol Sci. 2002 Nov;23(11):497-9 [12413798] Cancer Lett. 2003 Apr 25;193(2):119-25 [12706867] Natl Toxicol Program Tech Rep Ser. 2003 May;(508):1-280 [12844193] Toxicol Lett. 2003 Oct 15;144(3):295-311 [12927348] Chem Res Toxicol. 2003 Sep;16(9):1130-7 [12971801] Toxicol Lett. 2003 Dec 10;145(3):239-47 [14580895] Environ Health Perspect. 2003 Nov;111(15):1819-26 [14630514] Phytochem Anal. 2004 Jan-Feb;15(1):36-9 [14979525] Toxicol Lett. 2004 Apr 15;150(1):29-42 [15068823] Drug Metab Rev. 2004 Feb;36(1):1-55 [15072438] Mutat Res. 2004 May 18;549(1-2):115-29 [15120966] Chem Res Toxicol. 2004 Jun;17(6):814-8 [15206902] Cancer Lett. 2004 Nov 25;215(2):151-8 [15488633] J Natl Cancer Inst. 1978 Sep;61(3):865-9 [278864] Gastroenterology. 1985 Apr;88(4):1050-4 [3972224] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oral treatment with ACCUTANE does not increase measures of anhedonia or depression in rats. AN - 68532188; 17933491 AB - Reports of depression and/or suicide with ACCUTANE (13-cis-retinoic acid (13-cis-RA)) use prompted studies in a rodent model to ascertain its potential effects. Previously, there were no effects on measures of anhedonia (intake of a saccharin-flavored solution) and depression (forced swim test (FST) behaviors) in rats treated with 7.5 or 22.5 mg/kg 13-cis-RA [S.A. Ferguson, F.J. Cisneros, B. Gough, J.P. Hanig, K.J. Berry, Chronic oral treatment with 13-cis-retinoic acid (isotretinoin) or all-trans-retinoic acid does not alter depression-like behaviors in rats, Toxicol. Sci. 87 (2005) 451-459.]. Here, dose and temporal thresholds were investigated by increasing the maximum 13-cis-RA dose to 30 mg/kg, extending treatment duration, and measuring behaviors repeatedly. Beginning on post-natal day 59, male and female Sprague-Dawley rats were gavaged with soybean oil, 7.5 or 30 mg/kg/day of 13-cis-RA for approximately 19 weeks. FST behaviors were measured after 24, 82, and 131 treatment days and saccharin intake (0.03% solution) was measured at baseline and after 14, 35, 56, and 112 treatment days. Body weight and food intake were not altered by treatment. FST durations of swim, climb/struggle, and immobility were unaffected by 13-cis-RA at any time during treatment. More males than females required "rescue" in the FST but there was no treatment effect on number of rats requiring early removal. 13-cis-RA treatment had no effects on saccharin intake at any time. Given that the 7.5 mg/kg dose produces serum levels which parallel those of humans [S.A. Ferguson, P.H. Siitonen, F.J. Cisneros, B. Gough, J.F. Young, Steady state pharmacokinetics of oral treatment with 13-cis-retinoic acid or all-trans-retinoic acid in male and female adult rats, Basic Clin. Pharmacol. Toxicol 98 (2006) 582-587.], these results are quite relevant. Combined with previous results, these results provide further evidence that 13-cis-RA does not produce behavioral alterations indicative of depression in rats. JF - Neurotoxicology and teratology AU - Ferguson, Sherry A AU - Cisneros, F Javier AU - Hanig, Joseph P AU - Berry, Kimberly J AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079 USA. Sherry.Ferguson@fda.hhs.gov PY - 2007 SP - 642 EP - 651 VL - 29 IS - 6 SN - 0892-0362, 0892-0362 KW - Teratogens KW - 0 KW - Isotretinoin KW - EH28UP18IF KW - Index Medicus KW - Administration, Oral KW - Eating -- drug effects KW - Animals KW - Swimming KW - Analysis of Variance KW - Sex Factors KW - Dose-Response Relationship, Drug KW - Disease Models, Animal KW - Rats KW - Animals, Newborn KW - Behavior, Animal -- drug effects KW - Rats, Sprague-Dawley KW - Drinking -- drug effects KW - Time Factors KW - Female KW - Male KW - Isotretinoin -- administration & dosage KW - Depression -- physiopathology KW - Depression -- drug therapy KW - Food Preferences -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68532188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Oral+treatment+with+ACCUTANE+does+not+increase+measures+of+anhedonia+or+depression+in+rats.&rft.au=Ferguson%2C+Sherry+A%3BCisneros%2C+F+Javier%3BHanig%2C+Joseph+P%3BBerry%2C+Kimberly+J&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2007-11-01&rft.volume=29&rft.issue=6&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-25 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of a proposed area equation for improved exothermic process control. AN - 68522118; 17982158 AB - Our understanding of heat transfer and meteorological theories and their applications for engineering control design have been refined since the collective work in ventilation engineering for manufacturing process was published by Hemeon in 1955. These refined theories were reviewed and used to develop a newly proposed equation to estimate buoyant plume area (A). The area is a key parameter in estimating the plume volumetric flow (Q=UA) required for exothermic process control. Subsequent to developing a theoretical equation for plume area (A), plume velocity and area data were collected in the laboratory using a thermal anemometer and a scale-model exothermic process. Laboratory results were compared to solutions provided by the proposed, American Conference of Governmental Industrial Hygienists (ACGIH) and Hemeon plume area equations to determine which equation most closely matched the laboratory data. To make this determination, either t-tests or Wilcoxon signed-rank tests were conducted (based on examination of data normality) to determine the difference between collected data and solutions from the proposed, ACGIH and Hemeon equations. Median differences and P-values from Wilcoxon signed-rank tests (non-parametric) indicate that the ACGIH and Hemeon plume area equations provide significantly lower values than the laboratory data. However, the proposed equation provided solutions that were not significantly different from the collected data. Results indicate that the plume area equations currently recommended by the ACGIH and Hemeon are not as accurate as the proposed equation over the range of parameters investigated. JF - The Annals of occupational hygiene AU - McKernan, John L AU - Ellenbecker, Michael J AU - Holcroft, Christina A AU - Petersen, Martin R AD - Division of Surveillance, Hazard Evaluation and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R14, Cincinnati, OH 45226, USA. jmckernan@cdc.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 725 EP - 738 VL - 51 IS - 8 SN - 0003-4878, 0003-4878 KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - Occupational Health KW - Equipment Design KW - Engineering KW - Air Pollutants, Occupational -- analysis KW - Humans KW - Temperature KW - Occupational Exposure -- prevention & control KW - Ventilation -- instrumentation KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68522118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Evaluation+of+a+proposed+area+equation+for+improved+exothermic+process+control.&rft.au=McKernan%2C+John+L%3BEllenbecker%2C+Michael+J%3BHolcroft%2C+Christina+A%3BPetersen%2C+Martin+R&rft.aulast=McKernan&rft.aufirst=John&rft.date=2007-11-01&rft.volume=51&rft.issue=8&rft.spage=725&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-16 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of two DNA template preparation methods for post-immunomagnetic separation detection of Cryptosporidium parvum in foods and beverages by PCR. AN - 68487547; 17890339 AB - Cryptosporidium parvum oocysts were recovered by immunomagnetic separation from six artificially contaminated foods. Two DNA isolation methods were subsequently evaluated by PCR. The FTA Concentrator-PS filter provided rapid and reproducible detection, although variability increased at lower inoculum levels (88% and 15% detection in high- and low-inoculum-level samples, respectively). Total DNA extraction generated consistent results at all oocyst levels but resulted in longer analysis time (100% and 59% detection in high- and low-inoculum-level samples, respectively). Also reflected in this study was that the matrix played an important role in the ability to recover oocysts, as sample turbidity, pH, and PCR inhibitors all influenced detection. JF - Applied and environmental microbiology AU - Frazar, Christian D AU - Orlandi, Palmer A AD - Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 7474 EP - 7476 VL - 73 IS - 22 SN - 0099-2240, 0099-2240 KW - DNA, Protozoan KW - 0 KW - Index Medicus KW - Animals KW - Reproducibility of Results KW - Hydrogen-Ion Concentration KW - Oocysts -- metabolism KW - Food Parasitology KW - Templates, Genetic KW - Oocysts -- growth & development KW - Immunomagnetic Separation -- methods KW - Cryptosporidium parvum -- isolation & purification KW - Beverages -- parasitology KW - Polymerase Chain Reaction -- methods KW - DNA, Protozoan -- genetics KW - Cryptosporidium parvum -- genetics KW - DNA, Protozoan -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68487547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Evaluation+of+two+DNA+template+preparation+methods+for+post-immunomagnetic+separation+detection+of+Cryptosporidium+parvum+in+foods+and+beverages+by+PCR.&rft.au=Frazar%2C+Christian+D%3BOrlandi%2C+Palmer+A&rft.aulast=Frazar&rft.aufirst=Christian&rft.date=2007-11-01&rft.volume=73&rft.issue=22&rft.spage=7474&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-11 N1 - Date created - 2007-11-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Food Microbiol. 2000 Mar 25;54(3):155-62 [10777065] MMWR Morb Mortal Wkly Rep. 2007 Mar 30;54(53):1-92 [17392681] Vet Parasitol. 2000 Nov 10;93(2):103-12 [11035228] J Clin Microbiol. 2000 Nov;38(11):3984-90 [11060056] Appl Environ Microbiol. 2001 Jun;67(6):2665-8 [11375178] J Food Prot. 2001 Nov;64(11):1793-8 [11726161] J Microbiol Methods. 2002 May;49(3):209-24 [11869786] J Food Prot. 2002 Aug;65(8):1345-8 [12182493] J Microbiol Methods. 2004 Sep;58(3):375-86 [15279942] MMWR Morb Mortal Wkly Rep. 1987 Aug 28;36(33):561-3 [3112550] Am J Trop Med Hyg. 1991 Dec;45(6):688-94 [1763795] N Engl J Med. 1994 Jul 21;331(3):161-7 [7818640] Int J Food Microbiol. 1996 Sep;32(1-2):1-26 [8880324] MMWR Morb Mortal Wkly Rep. 1997 Jan 10;46(1):4-8 [9011776] Appl Environ Microbiol. 1997 May;63(5):2029-37 [9143132] Am J Trop Med Hyg. 1997 Dec;57(6):683-6 [9430527] FEMS Immunol Med Microbiol. 1999 Mar;23(3):213-20 [10219593] Appl Environ Microbiol. 2005 Feb;71(2):898-903 [15691946] Foodborne Pathog Dis. 2004 Winter;1(4):216-22 [15992283] J Clin Microbiol. 2000 Jun;38(6):2271-7 [10834988] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Haff disease after eating salmon. AN - 68481584; 17984750 AB - While fish consumption is considered a component of a heart-healthy diet, many illnesses have been associated with eating contaminated fish. The authors describe two cases of muscle weakness and rhabdomyolysis that occurred after eating salmon. Cases of rhabdomyolysis and muscle weakness after consumption of fresh water fish have rarely been reported in the United States but have been frequently reported from the Baltic region. This illness is known as Haff disease. While the etiology is unknown, it is felt to be a toxin. Palytoxin, found in marine fish, has been associated with rhabdomyolysis, and may serve as a model for further study of the suspected toxin responsible for rhabdomyolysis after consumption of fresh water fish. If a case of Haff disease is suspected, contact the Centers for Disease Control and Prevention and collect any uneaten fish, which may be sent for laboratory analysis. JF - Southern medical journal AU - Langley, Ricky L AU - Bobbitt, William H AD - North Carolina Department of Health and Human Services, Raleigh, North Carolina, USA. rick.langley@ncmail.net Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1147 EP - 1150 VL - 100 IS - 11 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Diagnosis, Differential KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Salmon KW - Rhabdomyolysis -- etiology KW - Foodborne Diseases -- etiology KW - Foodborne Diseases -- diagnosis KW - Rhabdomyolysis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68481584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Haff+disease+after+eating+salmon.&rft.au=Langley%2C+Ricky+L%3BBobbitt%2C+William+H&rft.aulast=Langley&rft.aufirst=Ricky&rft.date=2007-11-01&rft.volume=100&rft.issue=11&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-08 N1 - Date created - 2007-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of the endocannabinoid system: therapeutic potential against cocaine dependence. AN - 68479251; 17945506 AB - Dependence on cocaine is still a main unresolved medical and social concern, and in spite of research efforts, no pharmacological therapy against cocaine dependence is yet available. Recent studies have shown that the endocannabinoid system participates in specific stages and aspects of drug dependence in general, and some of this evidence suggests an involvement of the cannabinoid system in cocaine effects. For example, cocaine administration has been shown to alter brain endocannabinoid levels, and the endocannabinoid system has been involved in long-term modifications of brain processes that might play a role in neuro/behavioral effects of psychostimulant drugs like cocaine. Human studies show that marijuana dependence is frequently associated with cocaine dependence, and that the cannabinoid receptor CNR1 gene polymorphism might be related to cocaine addiction. This article will review the main papers in the field showing how a modulation of different components of the cannabinoid system might interact with some of the neurobiological/behavioral effects of cocaine related to its reinforcing effects, evaluated in preclinical models or in clinical settings. The goal of this review will be to provide insights into the complex picture of cocaine abuse and addiction, and to extrapolate from such endocannabinoid-cocaine interactions useful information to test the therapeutic potential of cannabinoid ligands and endocannabinoid-level enhancers against cocaine dependence for future preclinical/clinical trials. JF - Pharmacological research AU - Tanda, Gianluigi AD - Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. gtanda@intra.nida.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 406 EP - 417 VL - 56 IS - 5 SN - 1043-6618, 1043-6618 KW - Cannabinoid Receptor Modulators KW - 0 KW - Central Nervous System Agents KW - Endocannabinoids KW - Index Medicus KW - Animals KW - Humans KW - Cannabinoid Receptor Modulators -- metabolism KW - Cocaine-Related Disorders -- drug therapy KW - Central Nervous System Agents -- therapeutic use KW - Cocaine-Related Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68479251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+research&rft.atitle=Modulation+of+the+endocannabinoid+system%3A+therapeutic+potential+against+cocaine+dependence.&rft.au=Tanda%2C+Gianluigi&rft.aulast=Tanda&rft.aufirst=Gianluigi&rft.date=2007-11-01&rft.volume=56&rft.issue=5&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Pharmacological+research&rft.issn=10436618&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2007-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurosci Biobehav Rev. 2004 Jan;27(8):813-20 [15019430] Mol Psychiatry. 2004 Oct;9(10):916-31 [15289816] Int J Addict. 1972;7(1):27-55 [5043838] J Pharmacol Exp Ther. 1975 Jul;194(1):74-81 [168349] Mol Pharmacol. 1976 May;12(3):345-52 [934055] Eur J Pharmacol. 1976 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Nov-Dec;58(6):806-19 [17220538] J Neurosci. 2007 Jan 24;27(4):791-5 [17251418] Neuropsychopharmacology. 2007 Mar;32(3):646-57 [16738542] J Pharmacol Exp Ther. 2007 Apr;321(1):370-80 [17210800] J Pharmacol Exp Ther. 2007 Apr;321(1):334-44 [17255465] Science. 1997 Oct 3;278(5335):52-8 [9311926] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Contact lens safety and the FDA: 1976 to the present. AN - 68462414; 17975433 AB - The U.S. Food and Drug Administration (FDA) performs many different functions to fulfill its responsibility of regulating medical devices. The various roles in premarket and postmarket safety are discussed with representative historic events involving the regulation of contact lenses and lens care products. Current challenges facing the contact lens industry to maintain safe use of these medical devices are explained, and future pathways to address these challenges are considered. JF - Eye & contact lens AU - Saviola, James F AD - Office of Device Evaluation, Division of Ophthalmic and Ear, Nose, and Throat Devices, Center for Divices and Radiological Health, U.S. Food and Drug Administration, Rockville, MD 20850, USA. james.saviola@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 404 EP - 9; discussion 410-1 VL - 33 IS - 6 Pt 2 SN - 1542-2321, 1542-2321 KW - Contact Lens Solutions KW - 0 KW - Index Medicus KW - United States KW - Information Dissemination -- methods KW - Consumer Product Safety KW - Contact Lens Solutions -- adverse effects KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Equipment Safety KW - Internet KW - United States Food and Drug Administration -- trends KW - Contact Lenses -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68462414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eye+%26+contact+lens&rft.atitle=Contact+lens+safety+and+the+FDA%3A+1976+to+the+present.&rft.au=Saviola%2C+James+F&rft.aulast=Saviola&rft.aufirst=James&rft.date=2007-11-01&rft.volume=33&rft.issue=6+Pt+2&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Eye+%26+contact+lens&rft.issn=15422321&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Portable XRF analysis of occupational air filter samples from different workplaces using different samplers: final results, summary and conclusions. AN - 68449743; 17968454 AB - This paper concludes a five-year program on research into the use of a portable X-ray fluorescence (XRF) analyzer for analyzing lead in air sampling filters from different industrial environments, including mining, manufacturing and recycling. The results from four of these environments have already been reported. The results from two additional metal processes are presented here. At both of these sites, lead was a minor component of the total airborne metals and interferences from other elements were minimal. Nevertheless, only results from the three sites where lead was the most abundant metal were used in the overall calculation of method accuracy. The XRF analyzer was used to interrogate the filters, which were then subjected to acid digestion and analysis by inductively-coupled plasma optical-emission spectroscopy (ICP-OES). The filter samples were collected using different filter-holders or "samplers" where the size (diameter), depth and homogeneity of aerosol deposit varied from sampler to sampler. The aerosol collection efficiencies of the samplers were expected to differ, especially for larger particles. The distribution of particles once having entered the sampler was also expected to differ between samplers. Samplers were paired to allow the between-sampler variability to be addressed, and, in some cases, internal sampler wall deposits were evaluated and compared to the filter catch. It was found, rather surprisingly, that analysis of the filter deposits (by ICP-OES) of all the samplers gave equivalent results. It was also found that deposits on some of the sampler walls, which in some protocols are considered part of the sample, could be significant in comparison to the filter deposit. If it is concluded that wall-deposits should be analyzed, then XRF analysis of the filter can only give a minimum estimate of the concentration. Techniques for the statistical analysis of field data were also developed as part of this program and have been reported elsewhere. The results, based on data from the three workplaces where lead was the major element present in the samples, are summarized here. A limit of detection and a limit of quantitation are provided. Analysis of some samples using a second analyzer with a different X-ray source technology indicated reasonable agreement for some metals (but this was not evaluated for lead). Provided it is only necessary to analyze the filters, most personal samplers will provide acceptable results when used with portable XRF analysis for lead around applicable limit values. JF - Journal of environmental monitoring : JEM AU - Harper, Martin AU - Pacolay, Bruce AU - Hintz, Patrick AU - Bartley, David L AU - Slaven, James E AU - Andrew, Michael E AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-3030, Morgantown, WV 26505, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1263 EP - 1270 VL - 9 IS - 11 SN - 1464-0325, 1464-0325 KW - Air Pollutants, Occupational KW - 0 KW - Metals KW - Index Medicus KW - Fluorescence KW - Filtration -- instrumentation KW - Metals -- analysis KW - Occupational Exposure KW - Spectrometry, X-Ray Emission -- methods KW - Air Pollutants, Occupational -- analysis KW - Workplace UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68449743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Portable+XRF+analysis+of+occupational+air+filter+samples+from+different+workplaces+using+different+samplers%3A+final+results%2C+summary+and+conclusions.&rft.au=Harper%2C+Martin%3BPacolay%2C+Bruce%3BHintz%2C+Patrick%3BBartley%2C+David+L%3BSlaven%2C+James+E%3BAndrew%2C+Michael+E&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2007-11-01&rft.volume=9&rft.issue=11&rft.spage=1263&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a field method for measuring manganese in welding fume. AN - 68446802; 17968446 AB - Workers who perform routine welding tasks are potentially exposed to fume that may contain manganese. Manganese may cause respiratory problems and is implicated in causing the occurrence of Parkinson-like symptoms. In this study, a field colorimetric method for extracting and measuring manganese in welding fume was developed. The method uses ultrasonic extraction with an acidic hydrogen peroxide solution to extract welding fume collected on polyvinyl chloride filters. Commercially available pre-packaged reagents are used to produce a colored solution, created by a reaction of manganese(ii) with 1-(2-pyridylazo)-2-naphthol. Absorbance measurements are then made using a portable spectrophotometer. The method detection limit and limit of quantification (LOQ) were 5.2 microg filter(-1) and 17 microg filter(-1), respectively, with a dynamic range up to 400 microg filter(-1). When the results are above the LOQ for the colorimetric method, the manganese masses are equivalent to those measured by the International Organization for Standardization Method 15202-2, which employs a strong acid digestion and analysis using inductively coupled plasma-optical emission spectrometry. JF - Journal of environmental monitoring : JEM AU - Dale Marcy, A AU - Drake, Pamela L AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Spokane Research Laboratory, 315 E. Montgomery Ave, Spokane, WA 99207, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1199 EP - 1204 VL - 9 IS - 11 SN - 1464-0325, 1464-0325 KW - Manganese KW - 42Z2K6ZL8P KW - Index Medicus KW - Sensitivity and Specificity KW - Occupational Exposure KW - Humans KW - Colorimetry KW - Manganese -- analysis KW - Welding KW - Spectrophotometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68446802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Development+of+a+field+method+for+measuring+manganese+in+welding+fume.&rft.au=Dale+Marcy%2C+A%3BDrake%2C+Pamela+L&rft.aulast=Dale+Marcy&rft.aufirst=A&rft.date=2007-11-01&rft.volume=9&rft.issue=11&rft.spage=1199&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pesticide dose estimates for children of Iowa farmers and non-farmers. AN - 68368426; 17659274 AB - Farm children have the potential to be exposed to pesticides. Biological monitoring is often employed to assess this exposure; however, the significance of the exposure is uncertain unless doses are estimated. In the spring and summer of 2001, 118 children (66 farm, 52 non-farm) of Iowa farm and non-farm households were recruited to participate in a study investigating potential take-home pesticide exposure. Each child provided an evening and morning urine sample at two visits spaced approximately 1 month apart, with the first sample collection taken within a few days after pesticide application. Estimated doses were calculated for atrazine, metolachlor, chlorpyrifos, and glyphosate from urinary metabolite concentrations derived from the spot urine samples and compared to EPA reference doses. For all pesticides except glyphosate, the doses from farm children were higher than doses from the non-farm children. The difference was statistically significant for atrazine (p<0.0001) but only marginally significant for chlorpyrifos and metolachlor (p = 0.07 and 0.1, respectively). Among farm children, geometric mean doses were higher for children on farms where a particular pesticide was applied compared to farms where that pesticide was not applied for all pesticides except glyphosate; results were significant for atrazine (p = 0.030) and metolachlor (p = 0.042), and marginally significant for chlorpyrifos (p = 0.057). The highest estimated doses for atrazine, chlorpyrifos, metolachlor, and glyphosate were 0.085, 1.96, 3.16, and 0.34 microg/kg/day, respectively. None of the doses exceeded any of the EPA reference values for atrazine, metolachlor, and glyphosate; however, all of the doses for chlorpyrifos exceeded the EPA chronic population adjusted reference value. Doses were similar for male and female children. A trend of decreasing dose with increasing age was observed for chlorpyrifos. JF - Environmental research AU - Curwin, Brian D AU - Hein, Misty J AU - Sanderson, Wayne T AU - Striley, Cynthia AU - Heederik, Dick AU - Kromhout, Hans AU - Reynolds, Stephen J AU - Alavanja, Michael C AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS R-14, Cincinnati, OH 45226, USA. bcurwin@cdc.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 307 EP - 315 VL - 105 IS - 3 SN - 0013-9351, 0013-9351 KW - Acetamides KW - 0 KW - Environmental Pollutants KW - Pesticides KW - glyphosate KW - 4632WW1X5A KW - Chlorpyrifos KW - JCS58I644W KW - Atrazine KW - QJA9M5H4IM KW - Glycine KW - TE7660XO1C KW - metolachlor KW - X0I01K05X2 KW - Index Medicus KW - Reference Values KW - Humans KW - Child KW - Glycine -- analogs & derivatives KW - Iowa KW - Child, Preschool KW - Acetamides -- urine KW - Atrazine -- urine KW - Case-Control Studies KW - Glycine -- urine KW - Urinalysis KW - Adolescent KW - Male KW - Female KW - Chlorpyrifos -- urine KW - Pesticides -- analysis KW - Agriculture -- methods KW - Pesticides -- urine KW - Environmental Exposure -- analysis KW - Environmental Pollutants -- urine KW - Environmental Exposure -- adverse effects KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68368426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Pesticide+dose+estimates+for+children+of+Iowa+farmers+and+non-farmers.&rft.au=Curwin%2C+Brian+D%3BHein%2C+Misty+J%3BSanderson%2C+Wayne+T%3BStriley%2C+Cynthia%3BHeederik%2C+Dick%3BKromhout%2C+Hans%3BReynolds%2C+Stephen+J%3BAlavanja%2C+Michael+C&rft.aulast=Curwin&rft.aufirst=Brian&rft.date=2007-11-01&rft.volume=105&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-03 N1 - Date created - 2007-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Malathion exposure and the incidence of cancer in the agricultural health study. AN - 68364044; 17720683 AB - Malathion is the most common organophosphate insecticide applied in the United States, and while some studies suggest that it may be clastogenic, its carcinogenicity has not been demonstrated in rodents. However, malathion has been associated with non-Hodgkin's lymphoma in several epidemiologic studies. The authors investigated associations between malathion exposure and cancer among 19,717 pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Information on lifetime years and days per year of use and intensity of malathion exposure was obtained with self-administered questionnaires prior to the onset of any cancer. The average follow-up time was 7.5 years (1993-2002). Rate ratios and 95% confidence intervals were calculated using Poisson regression, adjusting for potential confounders. Overall, lifetime days of malathion use (top tertile of exposure, >39 days) was not associated with all cancers combined (rate ratio = 0.97, 95% confidence interval: 0.81, 1.15). The risk of non-Hodgkin's lymphoma was not associated with malathion use, although the number of cases was small. The risk of melanoma with more than 39 lifetime exposure-days was 0.39 (95% confidence interval: 0.14, 1.03). In summary, malathion exposure was not clearly associated with cancer at any of the sites examined. Although the rate ratios for melanoma were reduced, small numbers and lack of experimental evidence suggest that the observed reductions may have arisen by chance. JF - American journal of epidemiology AU - Bonner, Matthew R AU - Coble, Joseph AU - Blair, Aaron AU - Beane Freeman, Laura E AU - Hoppin, Jane A AU - Sandler, Dale P AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 1023 EP - 1034 VL - 166 IS - 9 SN - 0002-9262, 0002-9262 KW - Insecticides KW - 0 KW - Malathion KW - U5N7SU872W KW - Index Medicus KW - Agriculture KW - Odds Ratio KW - Prospective Studies KW - International Classification of Diseases KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Incidence KW - Confidence Intervals KW - Middle Aged KW - North Carolina -- epidemiology KW - Male KW - Iowa -- epidemiology KW - Female KW - Insecticides -- adverse effects KW - Malathion -- adverse effects KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- chemically induced KW - Agricultural Workers' Diseases -- chemically induced KW - Neoplasms -- epidemiology KW - Occupational Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68364044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Malathion+exposure+and+the+incidence+of+cancer+in+the+agricultural+health+study.&rft.au=Bonner%2C+Matthew+R%3BCoble%2C+Joseph%3BBlair%2C+Aaron%3BBeane+Freeman%2C+Laura+E%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+C+R&rft.aulast=Bonner&rft.aufirst=Matthew&rft.date=2007-11-01&rft.volume=166&rft.issue=9&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-12 N1 - Date created - 2007-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Leukemia following breast cancer: an international population-based study of 376,825 women. AN - 68328672; 17221155 AB - To quantify long-term temporal trends in the excess absolute risk (EAR) of secondary leukemia among breast cancer (BC) survivors, using multivariate analyses to evaluate the effects of subtype, age at BC diagnosis, attained age, and calendar year. We identified 376,825 1-year survivors of BC within 4 nationwide, population-based cancer registries in Sweden, Denmark, Finland, and Norway (1943-2001). Estimates of EAR (per 100,000 person-years) were modeled using Poisson regression methods and cumulative risks calculated using a competing risk model. A total of 687 non-chronic lymphocytic leukemias (EAR = 9.05; 95% confidence interval (CI) = 7.5-10.7) was reported. Significantly elevated risks were observed for the first time for chronic myeloid leukemia (CML) (EAR = 2.06; 95% CI = 1.3-2.9) and acute lymphoblastic leukemia (ALL) (EAR = 0.62; 95% CI = 0.2-1.1), in addition to acute myeloid leukemia (AML) (EAR = 5.00; 95% CI = 3.9-6.2). Excesses of CML, ALL, AML and all leukemias combined persisted over 25 years after BC diagnosis. For all leukemias, EAR decreased with increasing calendar year (P = 0.04) of BC diagnosis. Risk for all leukemia and AML by calendar year of BC diagnosis depended on age at diagnosis. For women diagnosed with BC after 1985, the 10-year cumulative risk of leukemia for those diagnosed before and after age 50 was small, 0.10% and 0.14%, respectively. Although secondary leukemia is a rare event, BC survivors experience statistically significant excesses for at least 25 years after diagnosis, including CML and ALL. Decreasing leukemia risks in recent calendar years likely reflect changes in treatment. JF - Breast cancer research and treatment AU - Howard, Regan A AU - Gilbert, Ethel S AU - Chen, Bingshu E AU - Hall, Per AU - Storm, Hans AU - Pukkala, Eero AU - Langmark, Froydis AU - Kaijser, Magnus AU - Andersson, Michael AU - Joensuu, Heikki AU - Fossa, Sophie D AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Executive Plaza South, Suite 7091, Bethesda, MD 20892, USA. reganho@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 359 EP - 368 VL - 105 IS - 3 SN - 0167-6806, 0167-6806 KW - Index Medicus KW - Leukemia, Radiation-Induced -- epidemiology KW - Aged, 80 and over KW - Risk Factors KW - Leukemia, Radiation-Induced -- complications KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Leukemia, Radiation-Induced -- diagnosis KW - Female KW - Neoplasms, Second Primary -- complications KW - Leukemia -- diagnosis KW - Neoplasms, Second Primary -- epidemiology KW - Breast Neoplasms -- diagnosis KW - Leukemia -- epidemiology KW - Neoplasms, Second Primary -- diagnosis KW - Leukemia -- complications KW - Breast Neoplasms -- epidemiology KW - Breast Neoplasms -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68328672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Leukemia+following+breast+cancer%3A+an+international+population-based+study+of+376%2C825+women.&rft.au=Howard%2C+Regan+A%3BGilbert%2C+Ethel+S%3BChen%2C+Bingshu+E%3BHall%2C+Per%3BStorm%2C+Hans%3BPukkala%2C+Eero%3BLangmark%2C+Froydis%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BJoensuu%2C+Heikki%3BFossa%2C+Sophie+D%3BTravis%2C+Lois+B&rft.aulast=Howard&rft.aufirst=Regan&rft.date=2007-11-01&rft.volume=105&rft.issue=3&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-09 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of exposure versus body burden data in deriving health guidance values. AN - 68184492; 17710608 AB - The Agency for Toxic Substances and Disease Registry (ATSDR) derives health-based guidance values to estimate daily human exposure to hazardous substances that are likely to be without appreciable risk of adverse noncancer effects for specific routes and durations of exposure. Most of these guidance values are derived from data showing external dose/health effect relationships. However, for chemicals that persist in the body, information on body burdens may provide more accurate understanding of their toxicity. This article evaluates the exposure versus body burden approaches using 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and lead as examples. JF - Journal of toxicology and environmental health. Part B, Critical reviews AU - Pohl, Hana R AU - Abadin, Henry G AU - Jones, Dennis E AU - De Rosa, Christopher T AD - U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA. hpohl@cdc.gov PY - 2007 SP - 401 EP - 415 VL - 10 IS - 6 KW - Environmental Pollutants KW - 0 KW - Polychlorinated Dibenzodioxins KW - Lead KW - 2P299V784P KW - Index Medicus KW - Uncertainty KW - Animals KW - No-Observed-Adverse-Effect Level KW - Humans KW - Risk Assessment KW - Environmental Pollutants -- standards KW - Environmental Pollutants -- toxicity KW - Lead -- toxicity KW - Body Burden KW - Environmental Exposure -- analysis KW - Polychlorinated Dibenzodioxins -- toxicity KW - Lead -- standards KW - Polychlorinated Dibenzodioxins -- standards KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68184492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+B%2C+Critical+reviews&rft.atitle=The+role+of+exposure+versus+body+burden+data+in+deriving+health+guidance+values.&rft.au=Pohl%2C+Hana+R%3BAbadin%2C+Henry+G%3BJones%2C+Dennis+E%3BDe+Rosa%2C+Christopher+T&rft.aulast=Pohl&rft.aufirst=Hana&rft.date=2007-11-01&rft.volume=10&rft.issue=6&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+B%2C+Critical+reviews&rft.issn=1521-6950&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-30 N1 - Date created - 2007-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The joint demand for health care, leisure, and commodities: Implications for health care finance and access in Vietnam AN - 61696439; 200813441 AB - This paper explores linkages between the demand for health care providers and the consumption of food, non-food goods, and leisure in Vietnam, using a mixed continuous/discrete dependent variable model. Cross-price elasticities calculated from the model suggest there are strong substitution effects between health care, leisure, and certain commodities. The model allows us to explore the implications of replacing user fees with alternative forms of health care finance, such as commodity taxes. In particular, the results suggest financing public health care services with a non-food sales tax rather than user fees would be more progressive and would improve access to care. Adapted from the source document. JF - The Journal of Development Studies AU - Meyerhoefer, Chad D AU - Sahn, David E AU - Younger, Stephen D AD - Agency for Healthcare Research and Quality, USA Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1475 EP - 1500 PB - Taylor & Francis, Abingdon UK VL - 43 IS - 8 SN - 0022-0388, 0022-0388 KW - Taxation KW - Leisure KW - Commodities KW - Health Care Services KW - Supply and Demand KW - Vietnam KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61696439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Development+Studies&rft.atitle=The+joint+demand+for+health+care%2C+leisure%2C+and+commodities%3A+Implications+for+health+care+finance+and+access+in+Vietnam&rft.au=Meyerhoefer%2C+Chad+D%3BSahn%2C+David+E%3BYounger%2C+Stephen+D&rft.aulast=Meyerhoefer&rft.aufirst=Chad&rft.date=2007-11-01&rft.volume=43&rft.issue=8&rft.spage=1475&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Development+Studies&rft.issn=00220388&rft_id=info:doi/10.1080%2F00220380701611527 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-05-02 N1 - Number of references - 30 N1 - Last updated - 2016-09-28 N1 - CODEN - JDVSA9 N1 - SubjectsTermNotLitGenreText - Vietnam; Supply and Demand; Health Care Services; Leisure; Commodities; Taxation DO - http://dx.doi.org/10.1080/00220380701611527 ER - TY - JOUR T1 - Perceptions of Americans and the Iraq Invasion: Implications for Understanding National Character Stereotypes AN - 57231745; 200809432 AB - This study examines perceptions of the 'typical American' from 49 cultures around the world. Contrary to the ethnocentric bias hypothesis, a strong agreement was found between in-group and out-group ratings on the American profile (assertive, open-minded, but antagonistic). In fact, Americans had a somewhat less desirable view of Americans than did others. Within cultures, in-group ratings were not systematically more favorable than out-group ratings. The Iraq invasion had a slight negative effect on perceptions of the typical American, but people around the world seem to draw a clear distinction between U.S. foreign policy and the character of the American people. National character stereotypes appear to have a variety of sources and to be perpetuated by both cognitive mechanisms and sociocultural forces. [Reprinted by permission of Sage Publications Inc., copyright 2007.] JF - Journal of Cross-Cultural Psychology AU - Terracciano, Antonio AU - McCrae, Robert R AD - National Institute on Aging, National Institutes of Health, Department of Health and Human Services terraccianoa@grc.nia.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 695 EP - 710 PB - Sage Publications, Thousand Oaks VL - 38 IS - 6 SN - 0022-0221, 0022-0221 KW - Foreign policy KW - American people KW - Perceptions KW - Wars KW - National identity KW - Stereotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57231745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Psychology&rft.atitle=Perceptions+of+Americans+and+the+Iraq+Invasion%3A+Implications+for+Understanding+National+Character+Stereotypes&rft.au=Terracciano%2C+Antonio%3BMcCrae%2C+Robert+R&rft.aulast=Terracciano&rft.aufirst=Antonio&rft.date=2007-11-01&rft.volume=38&rft.issue=6&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Psychology&rft.issn=00220221&rft_id=info:doi/10.1177%2F0022022107308586 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JCPGB5 N1 - SubjectsTermNotLitGenreText - National identity; Wars; Perceptions; American people; Stereotypes; Foreign policy DO - http://dx.doi.org/10.1177/0022022107308586 ER - TY - JOUR T1 - Assessment, Authorization and Access to Medicaid Managed Mental Health Care AN - 57218660; 200804663 AB - Examined were effects on access of managed care assessment and authorization processes in California's 57 county mental health plans. Primary data on managed care implementation were collected from surveys of county plan administrators; secondary data were from Medicaid claims and enrollment files. Using multivariate fixed effects regression, we found that following implementation of managed care, greater access occurred in county plans where assessments and treatment were performed by the same clinician, and where service authorizations were made more rapidly. Lower access occurred in county plans where treating clinicians authorized services themselves. Results confirm the significant effects of managed care processes on outcomes and highlight the importance of system capacity. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Masland, Mary C AU - Snowden, Lonnie R AU - Wallace, Neal T AD - Department of Psychology, Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, 2140 Shattuck Ave, #409, Berkeley, CA 94720-1414, USA mmasland@berkeley.edu Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 548 EP - 562 PB - Springer, Dordrecht The Netherlands VL - 34 IS - 6 SN - 0894-587X, 0894-587X KW - Assessment KW - Managed care KW - Managed mental health care KW - Enrollment KW - Medicaid KW - Access KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57218660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Assessment%2C+Authorization+and+Access+to+Medicaid+Managed+Mental+Health+Care&rft.au=Masland%2C+Mary+C%3BSnowden%2C+Lonnie+R%3BWallace%2C+Neal+T&rft.aulast=Masland&rft.aufirst=Mary&rft.date=2007-11-01&rft.volume=34&rft.issue=6&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-007-0138-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Managed care; Assessment; Access; Medicaid; Enrollment; Managed mental health care DO - http://dx.doi.org/10.1007/s10488-007-0138-7 ER - TY - JOUR T1 - Development and application of reservoir models and artificial neural networks for optimizing ventilation air requirements in development mining of coal seams AN - 51244734; 2008-069547 AB - In longwall development mining of coal seams, planning, optimizing and providing adequate ventilation are very important steps to eliminate the accumulation of explosive methane-air mixtures in the working environment. Mine operators usually try to supply maximum ventilation air based on the capacity of the system and the predicted need underground. This approach is neither economical nor safer as ventilation capacity may decrease in time depending on various mining and coalbed parameters. Thus, it is important to develop better engineered approaches to optimize mine ventilation effectiveness and, therefore, to ensure a safer work environment. This study presents an approach using coalbed methane reservoir modeling and an artificial neural network (ANN) design for prediction and optimization of methane inflows and ventilation air requirements to maintain methane concentrations below statutory limits. A coalbed reservoir model of a three-entry development section, which is typical of Pittsburgh Coalbed mines in the Southwestern Pennsylvania section of Northern Appalachian Basin, was developed taking into account the presence and absence of shielding boreholes around the entries against methane inflow. In the model, grids were dynamically controlled to simulate the advance of mining for parametric simulations. Development and application of artificial neural networks as an optimization tool for ventilation requirements are introduced. Model predictions are used to develop, train, and test artificial neural networks to optimize ventilation requirements. The sensitivity and applications of proposed networks for predicting simulator data are presented and discussed. Results show that reservoir simulations and integrated ANN models can be practical and powerful tools for predicting methane emissions and optimization of ventilation air requirements. JF - International Journal of Coal Geology AU - Karacan, C Ozgen Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 221 EP - 239 PB - Elsevier, Amsterdam VL - 72 IS - 3-4 SN - 0166-5162, 0166-5162 KW - United States KW - North America KW - mining KW - mines KW - numerical models KW - underground mining KW - natural gas KW - coal mines KW - optimization KW - Appalachians KW - petroleum KW - coal seams KW - reservoir rocks KW - ventilation KW - artificial intelligence KW - boreholes KW - Appalachian Basin KW - coalbed methane KW - applications KW - neural networks KW - Pennsylvania KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51244734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Development+and+application+of+reservoir+models+and+artificial+neural+networks+for+optimizing+ventilation+air+requirements+in+development+mining+of+coal+seams&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2007-11-01&rft.volume=72&rft.issue=3-4&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2007.02.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2008-01-01 N1 - Number of references - 24 N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Appalachian Basin; Appalachians; applications; artificial intelligence; boreholes; coal mines; coal seams; coalbed methane; mines; mining; natural gas; neural networks; North America; numerical models; optimization; Pennsylvania; petroleum; reservoir rocks; underground mining; United States; ventilation DO - http://dx.doi.org/10.1016/j.coal.2007.02.003 ER - TY - JOUR T1 - Swelling-induced volumetric strains internal to a stressed coal associated with CO (sub 2) sorption AN - 51244710; 2008-069546 AB - It is generally accepted that typical coalbed gases (methane and carbon dioxide) are sorbed (both adsorbed and absorbed) in the coal matrix causing it to swell and resulting in local stress and strain variations in a coalbed confined under overburden pressure. The swelling, interactions of gases within the coal matrix and the resultant changes in the permeability, sorption, gas flow mechanics in the reservoir, and stress state of the coal can impact a number of reservoir-related factors. These include effective production of coalbed methane, degasification of future mining areas by drilling horizontal and vertical degasification wells, injection of CO (sub 2) as an enhanced coalbed methane recovery technique, and concurrent CO (sub 2) sequestration. Such information can also provide an understanding of the mechanisms behind gas outbursts in underground coal mines. The spatio-temporal volumetric strains in a consolidated Pittsburgh seam coal sample were evaluated while both confining pressure and carbon dioxide (CO (sub 2) ) pore pressure were increased to keep a constant positive effective stress on the sample. The changes internal to the sample were evaluated by maps of density and atomic number determined by dual-energy X-ray computed tomography (X-ray CT). Early-time images, as soon as CO (sub 2) was introduced, were also used to calculate the macroporosity in the coal sample. Scanning electron microscopy (SEM) and photographic images of the polished section of the coal sample at X-ray CT image location were used to identify the microlithotypes and microstructures. The CO (sub 2) sorption-associated swelling and volumetric strains in consolidated coal under constant effective stress are heterogeneous processes depending on the lithotypes present. In the time scale of the experiment, vitrite showed the highest degree of swelling due to dissolution of CO (sub 2) , while the clay (kaolinite) and inertite region was compressed in response. The volumetric strains associated with swelling and compression were between + or -15% depending on the location. Although the effective stress on the sample was constant, it varied within the sample as a result of the internal stresses created by gas sorption-related structural changes. SEM images and porosity calculations revealed that the kaolinite and inertite bearing layer was highly porous, which enabled the fastest CO (sub 2) uptake and the highest degree of compression. JF - International Journal of Coal Geology AU - Karacan, C Ozgen Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 209 EP - 220 PB - Elsevier, Amsterdam VL - 72 IS - 3-4 SN - 0166-5162, 0166-5162 KW - United States KW - silicates KW - horizontal drilling KW - sorption KW - Pittsburgh Coal KW - strain KW - Pennsylvanian KW - natural gas KW - petroleum KW - carbon dioxide KW - sedimentary rocks KW - coal KW - directional drilling KW - drilling KW - degassing KW - mines KW - inertite KW - carbon sequestration KW - Paleozoic KW - stress KW - coal mines KW - Carboniferous KW - kaolinite KW - recovery KW - gases KW - clay minerals KW - X-ray data KW - volume KW - coalbed methane KW - petrography KW - sheet silicates KW - Pennsylvania KW - computed tomography data KW - SEM data KW - 29A:Economic geology, geology of energy sources KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51244710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Swelling-induced+volumetric+strains+internal+to+a+stressed+coal+associated+with+CO+%28sub+2%29+sorption&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2007-11-01&rft.volume=72&rft.issue=3-4&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2007.01.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2008-01-01 N1 - Number of references - 31 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; carbon sequestration; Carboniferous; clay minerals; coal; coal mines; coalbed methane; computed tomography data; degassing; directional drilling; drilling; gases; horizontal drilling; inertite; kaolinite; mines; natural gas; Paleozoic; Pennsylvania; Pennsylvanian; petrography; petroleum; Pittsburgh Coal; recovery; sedimentary rocks; SEM data; sheet silicates; silicates; sorption; strain; stress; United States; volume; X-ray data DO - http://dx.doi.org/10.1016/j.coal.2007.01.003 ER - TY - JOUR T1 - Methods for determining roof fall risk in underground mines AN - 51017188; 2008-088171 AB - Reducing the number of roof fall injuries is a goal of the NIOSH mine safety research program. Central to this effort is the development of assessment techniques to help identify the nature of the risks associated with working under potentially hazardous roof conditions. This paper discusses a method to determine the roof fall risk using a qualitative risk-analysis technique. The ability to determine roof fall risk has been a long-standing goal of safety professionals and could provide the kind of information needed by on-site personnel responsible for worker safety to mitigate roof fall injuries. JF - Mining Engineering AU - Iannacchione, A AU - Prosser, I AU - Esterhuizen, G AU - Bajpayee, T Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 47 EP - 53 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO VL - 59 IS - 11 SN - 0026-5187, 0026-5187 KW - mining KW - mines KW - monitoring KW - geologic hazards KW - underground mining KW - roof control KW - statistical analysis KW - prediction KW - standardization KW - safety KW - risk assessment KW - probability KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51017188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mining+Engineering&rft.atitle=Methods+for+determining+roof+fall+risk+in+underground+mines&rft.au=Iannacchione%2C+A%3BProsser%2C+I%3BEsterhuizen%2C+G%3BBajpayee%2C+T&rft.aulast=Iannacchione&rft.aufirst=A&rft.date=2007-11-01&rft.volume=59&rft.issue=11&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Mining+Engineering&rft.issn=00265187&rft_id=info:doi/ L2 - http://me.smenet.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 19 N1 - PubXState - CO N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - CODEN - MIENAB N1 - SubjectsTermNotLitGenreText - geologic hazards; mines; mining; monitoring; prediction; probability; risk assessment; roof control; safety; standardization; statistical analysis; underground mining ER - TY - JOUR T1 - Outcomes of a randomized trial of continuum of care services for children in a child welfare system AN - 37023345; 3803945 AB - The Connecticut Department of Children and Families Title IV-E waiver demonstration evaluated whether the well-being of children approved for residential mental health services could be improved, and lengths of stay in restrictive placements reduced, by providing case rate payments to community agencies to provide continuum of care services. Children between ages 7 and 15 were randomly assigned to either the demonstration group (n = 78) or to usual state-supported services (n = 79). One-year outcome results indicated that in a situation that is less costly, improvement in outcomes occurred in less restrictive settings. Continuum of care services were more effective in 1) returning children to in-home placements, 2) reducing the length of stay in restrictive placements, and (3) utilizing higher levels of case management through coordination among agencies and family support services. © (2007) Child Welfare League of America. Reprinted by permission JF - Child welfare AU - Holden, E Wayne AU - O'Connell, Susan Rousseau AU - Liao, Qinghong AU - Krivelyova, Anna AU - Connor, Tim AU - Blau, Gary M AU - Long, Dorian AD - RTI International ; Community Health Resources, Connecticut ; MACRO International, Atlanta ; University of Wisconsin ; US Substance Abuse and Mental Health Services Administration Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 89 EP - 114 VL - 86 IS - 6 SN - 0009-4021, 0009-4021 KW - Sociology KW - U.S.A. KW - Evaluation KW - Family policy KW - Surveys KW - Mental health KW - Social policy KW - Child care KW - Connecticut KW - Child welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37023345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+welfare&rft.atitle=Outcomes+of+a+randomized+trial+of+continuum+of+care+services+for+children+in+a+child+welfare+system&rft.au=Holden%2C+E+Wayne%3BO%27Connell%2C+Susan+Rousseau%3BLiao%2C+Qinghong%3BKrivelyova%2C+Anna%3BConnor%2C+Tim%3BBlau%2C+Gary+M%3BLong%2C+Dorian&rft.aulast=Holden&rft.aufirst=E&rft.date=2007-11-01&rft.volume=86&rft.issue=6&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Child+welfare&rft.issn=00094021&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7947 5772 7954; 4774 9874 5574 10472 11888; 12429; 4551; 2192; 2208 2212; 11888 10472; 97 433 293 14 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS: STUDIES OF [alpha]-METHYLSTYRENE (CAS NO. 98-83-9) IN F344/N RATS AND B6C3F^sub 1^ MICE (INHALATION STUDIES) AN - 236521020; 18685715 AB - α-Methylstyrene is used to make heat-resistant acrylonitrile-butathene-styrene resins and polymers. We studied the effects of a-methylstyrene on male and female rats and mice to identify potential toxic or cancer-related hazards. We exposed groups of 50 male and female rats to atmospheres containing 100, 300, or 1,000 parts per million (ppm) of a-methylstyrene 6 hours per day, 5 days a week for 2 years. Groups of 50 male and female mice were similarly exposed to atmospheres containing 100, 300, or 600 ppm a-methylstyrene. Control animals were housed in exposure chambers for similar periods but with no test chemical in their air. At the end of the study, tissues from more than 40 sites were examined for every animal. Survival was similar for animals receiving a-methylstyrene and the controls, but the average body weight for each animal group receiving the highest concentration of a-methylstyrene was less than that for the control group. Male rats exposed to a-methylstyrene had increased rates of tumors of the kidney and a slightly increased rate of mononuclear cell leukemia. Female mice exposed to a-methylstyrene had increased rates of a variety of liver cancers, and male mice also had slightly increased rates of liver tumors. We conclude that exposure to a-methylstyrene in the air caused kidney tumors, and possibly mononuclear cell leukemia, in male rats. We conclude that a-methylstyrene caused liver cancer in female mice, and also possibly in male mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1 EP - 210 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Air Pollutants, Occupational KW - Carcinogens KW - Mutagens KW - Styrenes KW - alpha-methylstyrol KW - Toxicology KW - Leukemia KW - Rodents KW - Kidney Neoplasms -- pathology KW - Animals KW - Kidney Neoplasms -- chemically induced KW - DNA Damage KW - Nose Diseases -- chemically induced KW - Mutagens -- administration & dosage KW - Neoplasms, Experimental -- pathology KW - Rats KW - Rats, Inbred F344 KW - Liver Neoplasms -- pathology KW - Styrenes -- administration & dosage KW - CHO Cells KW - Leukemia, Myeloid -- pathology KW - Male KW - Kidney -- pathology KW - Cricetulus KW - Micronuclei, Chromosome-Defective -- chemically induced KW - Kidney -- drug effects KW - Liver Neoplasms -- chemically induced KW - Mice KW - Leukemia, Myeloid -- chemically induced KW - Mice, Inbred Strains KW - Inhalation Exposure KW - Body Weight -- drug effects KW - Female KW - Cricetinae KW - Neoplasms, Experimental -- etiology KW - Toxicity Tests KW - Carcinogens -- toxicity KW - Mutagens -- toxicity KW - Air Pollutants, Occupational -- toxicity KW - Styrenes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236521020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS%3A+STUDIES+OF+%5Balpha%5D-METHYLSTYRENE+%28CAS+NO.+98-83-9%29+IN+F344%2FN+RATS+AND+B6C3F%5Esub+1%5E+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-11-01&rft.volume=&rft.issue=543&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2007 N1 - Document feature - Tables; Graphs; Photographs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 236491904 AB - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236491904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-11-01&rft.volume=&rft.issue=543&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2007 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 236445513 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236445513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2007-11-01&rft.volume=&rft.issue=543&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2007 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Two Domains of Cytotoxic Necrotizing Factor Type 1 Bind the Cellular Receptor, Laminin Receptor Precursor Protein AN - 21008620; 7931944 AB - Cytotoxic necrotizing factor type 1 (CNF1) and CNF2 are highly homologous toxins that are produced by certain pathogenic strains of Escherichia coli. These 1,014-amino-acid toxins catalyze the deamidation of a specific glutamine residue in RhoA, Rac1, and Cdc42 and consist of a putative N-terminal binding domain, a transmembrane region, and a C-terminal catalytic domain. To define the regions of CNF1 that are responsible for binding of the toxin to its cellular receptor, the laminin receptor precursor protein (LRP), a series of CNF1 truncated toxins were characterized and assessed for toxin binding. In particular, three truncated toxins, Delta N63, Delta N545, and Delta C469, retained conformational integrity and in vitro enzymatic activity and were immunologically reactive against a panel of anti-CNF1 monoclonal antibodies (MAbs). Based on a comparison of these truncated toxins with wild-type CNF1 and CNF2 in LRP and HEp-2 cell binding assays and in MAb and LRP competitive binding inhibition assays and based on the results of confocal microscopy, we concluded that CNF1 contains two major binding regions: one located within the N terminus, which contained amino acids 135 to 164, and one which resided in the C terminus and included amino acids 683 to 730. The data further indicate that CNF1 can bind to an additional receptor(s) on HEp-2 cells and that LRP can also serve as a cellular receptor for CNF2. JF - Infection and Immunity AU - McNichol, Beth A AU - Rasmussen, Susan B AU - Carvalho, Humberto M AU - Meysick, Karen C AU - O'Brien, Alison D AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. FDA/CBER, Bethesda, Maryland 20892 Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 5095 EP - 5104 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 11 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Glutamine KW - Amino acids KW - Data processing KW - Monoclonal antibodies KW - Rac1 protein KW - Cdc42 protein KW - laminin receptors KW - Toxins KW - RhoA protein KW - Cytotoxic necrotizing factor KW - Confocal microscopy KW - Escherichia coli KW - Enzymatic activity KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21008620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Two+Domains+of+Cytotoxic+Necrotizing+Factor+Type+1+Bind+the+Cellular+Receptor%2C+Laminin+Receptor+Precursor+Protein&rft.au=McNichol%2C+Beth+A%3BRasmussen%2C+Susan+B%3BCarvalho%2C+Humberto+M%3BMeysick%2C+Karen+C%3BO%27Brien%2C+Alison+D&rft.aulast=McNichol&rft.aufirst=Beth&rft.date=2007-11-01&rft.volume=75&rft.issue=11&rft.spage=5095&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Glutamine; Data processing; Amino acids; Monoclonal antibodies; Rac1 protein; Cytotoxic necrotizing factor; Confocal microscopy; Cdc42 protein; Enzymatic activity; laminin receptors; Toxins; RhoA protein; Escherichia coli ER - TY - JOUR T1 - Levels of retinyl palmitate and retinol in the skin of SKH-1 mice topically treated with retinyl palmitate and concomitant exposure to simulated solar light for thirteen weeks AN - 20891036; 8398077 AB - Retinyl esters account for more than 70% of the endogenous vitamin A found in human skin, and retinyl palmitate is one of the retinyl esters in this pool. Human skin is also exposed to retinyl palmitate exogenously through the topical application of cosmetic and skin care products that contain retinyl palmitate. To date, there is limited information on the penetration and distribution of retinyl palmitate and vitamin A within in the skin. In this study, the accumulation of retinyl palmitate and generation of retinol in the skin of male and female SKH-1 mice that received repeated topical applications of creams containing 0.0%, 0.1%, 0.5%, 1.0%, 5.0%, 10%, or 13% of retinyl palmitate 5 days a week for a period of 13 weeks were studied. Because products containing retinyl palmitate are frequently applied to sun-exposed skin, and because it is well established that exposure to sunlight and UV light can alter cutaneous levels of retinoids, mice in this study were additionally exposed 5 days a week to simulated solar light. The results showed that retinyl palmitate diffused into the skin and was partially hydrolyzed to retinol. The levels of retinyl palmitate in the skin of mice that were administered retinyl palmitate cream were higher than control values, and levels of both retinyl palmitate and retinol increased with the application of higher concentrations of retinyl palmitate in the cream. Our results indicate that topically applied retinyl palmitate may alter the normal physiological levels of retinyl palmitate and retinol in the skin of SKH-1 mice and may have a significant impact on vitamin A homeostasis in the skin. JF - Toxicology and Industrial Health AU - Yan, J AU - Xia, Q AU - Warner, W G AU - Boudreau, MD AU - Warbritton, A AU - Howard, P C AU - Fu, P P AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA, peterfu@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 581 EP - 589 VL - 23 IS - 10 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - Skin KW - Cosmetics KW - Homeostasis KW - Esters KW - Light effects KW - Topical application KW - U.V. radiation KW - Palmitic acid KW - Vitamin A KW - Cream KW - Sunlight KW - Retinoids KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20891036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Levels+of+retinyl+palmitate+and+retinol+in+the+skin+of+SKH-1+mice+topically+treated+with+retinyl+palmitate+and+concomitant+exposure+to+simulated+solar+light+for+thirteen+weeks&rft.au=Yan%2C+J%3BXia%2C+Q%3BWarner%2C+W+G%3BBoudreau%2C+MD%3BWarbritton%2C+A%3BHoward%2C+P+C%3BFu%2C+P+P&rft.aulast=Yan&rft.aufirst=J&rft.date=2007-11-01&rft.volume=23&rft.issue=10&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233708090904 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - U.V. radiation; Skin; Vitamin A; Palmitic acid; Cream; Sunlight; Cosmetics; Homeostasis; Retinoids; Esters; Topical application; Light effects DO - http://dx.doi.org/10.1177/0748233708090904 ER - TY - JOUR T1 - UVA photoirradiation of anhydroretinol - formation of singlet oxygen and superoxide AN - 20889850; 8398082 AB - Anhydroretinol is a metabolite of vitamin A (retinol) and a major photodecomposition product of retinyl palmitate and retinyl acetate. Anhydroretinol is biologically active, inducing cell death in lymphoblastoid cells, prevention of N-methyl-N-nitrosourea-induced mammary cancer, and inhibition of cell growth in lymphocytes. We have previously determined that photoirradiation of anhydroretinol in the presence of a lipid, methyl linoleate, with UVA light-induced lipid peroxidation. In the present study, electron spin resonance (ESR) spin-trap techniques were employed to explore the mechanism of lipid peroxidation initiation. Irradiation of anhydroretinol by UVA in the presence of 2,2,6,6-tetramethylpiperidine (TEMP), a specific probe for singlet oxygen, resulted in the formation of TEMPO, indicating that singlet oxygen was generated. During photoirradiation in the presence of 5,5-dimethyl N-oxide pyrroline (DMPO), a specific probe for superoxide, ESR signals for DMPO-OOH were formed, and these signals were quenched by superoxide dismutase. The involvement of singlet oxygen on the induction of lipid peroxidation was also evidenced by the observation that lipid peroxidation was inhibited by sodium azide and enhanced by deuterium oxide. Our overall results provide evidence that photoirradiation of anhydroretinol with UVA light generates reactive oxygen species, e.g. singlet oxygen and superoxide, which mediate the induction of lipid peroxidation. JF - Toxicology and Industrial Health AU - Yin, J J AU - Xia, Q AU - Fu, P P AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA, junjie.yin@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 625 EP - 631 VL - 23 IS - 10 SN - 0748-2337, 0748-2337 KW - Toxicology Abstracts KW - Sodium azide KW - N-Oxides KW - Probes KW - Metabolites KW - Lymphocytes KW - Acetic acid KW - Cancer KW - Lipid peroxidation KW - Light effects KW - Cell death KW - U.V. radiation KW - Reactive oxygen species KW - Radiation KW - Superoxide dismutase KW - Palmitic acid KW - Vitamin A KW - oxides KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20889850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=UVA+photoirradiation+of+anhydroretinol+-+formation+of+singlet+oxygen+and+superoxide&rft.au=Yin%2C+J+J%3BXia%2C+Q%3BFu%2C+P+P&rft.aulast=Yin&rft.aufirst=J&rft.date=2007-11-01&rft.volume=23&rft.issue=10&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233708090909 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sodium azide; Probes; N-Oxides; Metabolites; Lymphocytes; Acetic acid; Lipid peroxidation; Cancer; Light effects; Cell death; U.V. radiation; Radiation; Reactive oxygen species; Superoxide dismutase; Vitamin A; Palmitic acid; oxides DO - http://dx.doi.org/10.1177/0748233708090909 ER - TY - JOUR T1 - The NIOSH Total Inward Leakage Project AN - 20883452; 8416021 AB - The National Institute for Occupational Safety and Health (NIOSH) conducts a range of efforts in the areas of research, information, and service. The NIOSH program portfolio focuses on relevance, quality, and impact. This is achieved through strong involvement of partners and stakeholders through the entire research continuum (conceiving, planning, conducting, translating, disseminating, and evaluating). The programmatic and support structures provide a foundation for staff to carry out its mission to provide national and world leadership to prevent work-related illnesses and injuries. JF - Occupational Health & Safety AU - Ann, R B AD - National Institute for Occupational Safety and Health's National Personal Protective Technology Laboratory, West Virginia University, USA Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 34 EP - 38 VL - 76 IS - 11 SN - 0362-4064, 0362-4064 KW - Health & Safety Science Abstracts KW - Leakage KW - Injuries KW - Occupational safety KW - foundations KW - portfolios KW - stakeholders KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20883452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+Health+%26+Safety&rft.atitle=The+NIOSH+Total+Inward+Leakage+Project&rft.au=Ann%2C+R+B&rft.aulast=Ann&rft.aufirst=R&rft.date=2007-11-01&rft.volume=76&rft.issue=11&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Occupational+Health+%26+Safety&rft.issn=03624064&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - stakeholders; Leakage; Occupational safety; Injuries; foundations; portfolios ER - TY - JOUR T1 - Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease AN - 20704872; 7630838 AB - Bacterial super-infection of influenza patients is the primary cause of excess mortality during influenza pandemics, with Staphylococcus aureus (S. aureus) having the highest fatality rate. The cotton rat (Sigmodon hispidus) is an excellent model for both influenza and S. aureus pathogenesis, and therefore a potential tool to model co-infection. We compared physiologic and pathologic changes in cotton rats infected with both S. aureus and influenza A/Wuhan/359 /95 (H3N2), with animals infected with each pathogen alone. Co-infected cotton rats demonstrated significantly higher mortality, lower temperatures on 2 and 3 days post-inoculation (p.i.), higher levels of bacteremia and pulmonary bacterial load 4 days p.i., and worse pathology 7 days p.i. Early indicators of exacerbated disease coincided with higher pulmonary mRNA levels for IL-1 beta , IL-6, IL-10 and IFNy, supporting the idea that these may contribute to disease severity. Our results demonstrate that the cotton rat is a good model of influenza and S. aureus co-infection, with increased mortality and hypothermia as well as prolonged bacterial duration indicative of synergistic disease that may be the result of increased induction of both pro- and anti-inflammatory cytokines. JF - Microbial Pathogenesis AU - Braun, LE AU - Sutter, DE AU - Eichelberger, M C AU - Pletneva, L AU - Kokai-Kun, J F AU - Blanco, JCG AU - Prince, G A AU - Ottolini, M G AD - Inc., Rockville, MD 20850, USA, Maryna.Eichelberger@fda.hhs.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 208 EP - 216 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 43 IS - 5-6 SN - 0882-4010, 0882-4010 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Temperature effects KW - Interleukin 6 KW - Hypothermia KW - Mortality KW - Influenza A KW - Interleukin 1 KW - Animal models KW - Sigmodon hispidus KW - Bacteremia KW - Pathogens KW - Superinfection KW - Interleukin 10 KW - mRNA KW - Inflammation KW - pandemics KW - Lung KW - Influenza A virus KW - Cytokines KW - Staphylococcus aureus KW - J 02410:Animal Diseases KW - V 22410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20704872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Co-infection+of+the+cotton+rat+%28Sigmodon+hispidus%29+with+Staphylococcus+aureus+and+influenza+A+virus+results+in+synergistic+disease&rft.au=Braun%2C+LE%3BSutter%2C+DE%3BEichelberger%2C+M+C%3BPletneva%2C+L%3BKokai-Kun%2C+J+F%3BBlanco%2C+JCG%3BPrince%2C+G+A%3BOttolini%2C+M+G&rft.aulast=Braun&rft.aufirst=LE&rft.date=2007-11-01&rft.volume=43&rft.issue=5-6&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2007.03.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Temperature effects; Mortality; Hypothermia; Influenza A; Interleukin 1; Animal models; Bacteremia; Pathogens; Superinfection; Interleukin 10; Inflammation; mRNA; pandemics; Lung; Cytokines; Influenza A virus; Sigmodon hispidus; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.micpath.2007.03.005 ER - TY - JOUR T1 - Comparison of Direct Genome Restriction Enzyme Analysis and Pulsed-Field Gel Electrophoresis for Typing of Vibrio vulnificus and Their Correspondence with Multilocus Sequence Typing Data AN - 20551099; 7928240 AB - We compared the potential of direct genome restriction enzyme analysis (DGREA) and pulsed-field gel electrophoresis (PFGE) for discriminating Vibrio vulnificus isolates from clinical (23) and environmental (17) sources. The genotypes generated by both methodologies were compared to previous multilocus sequence typing (MLST) data. DGREA established clearer relationships among V. vulnificus strains and was more consistent with MLST than with PFGE. DGREA is a very promising tool for epidemiological and ecological studies of V. vulnificus. JF - Applied and Environmental Microbiology AU - Gonzalez-Escalona, Narjol AU - Whitney, Brooke AU - Jaykus, Lee-Ann AU - DePaola, Angelo AD - Department of Food Science, North Carolina State University, Raleigh, North Carolina. FDA Gulf Coast Seafood Laboratory, Dauphin Island, Alabama Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 7494 EP - 7500 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 22 SN - 0099-2240, 0099-2240 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Vibrio vulnificus KW - Pulsed-field gel electrophoresis KW - Enzymes KW - Genotypes KW - multilocus sequence typing KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20551099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Comparison+of+Direct+Genome+Restriction+Enzyme+Analysis+and+Pulsed-Field+Gel+Electrophoresis+for+Typing+of+Vibrio+vulnificus+and+Their+Correspondence+with+Multilocus+Sequence+Typing+Data&rft.au=Gonzalez-Escalona%2C+Narjol%3BWhitney%2C+Brooke%3BJaykus%2C+Lee-Ann%3BDePaola%2C+Angelo&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2007-11-01&rft.volume=73&rft.issue=22&rft.spage=7494&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Pulsed-field gel electrophoresis; Enzymes; Genotypes; multilocus sequence typing; Vibrio vulnificus ER - TY - JOUR T1 - A systematic review of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis AN - 20527752; 7745882 AB - Conventional diagnostic tests for tuberculosis have several limitations and are often unhelpful in establishing the diagnosis of extrapulmonary tuberculosis. Although commercial serological antibody based tests are available, their usefulness in the diagnosis of extrapulmonary tuberculosis is unknown. A systematic review was conducted to assess the accuracy of commercial serological antibody detection tests for the diagnosis of extrapulmonary tuberculosis. In a comprehensive search, 21 studies that reported data on sensitivity and specificity for extrapulmonary tuberculosis were identified. These studies evaluated seven different commercial tests, with Anda-TB IgG accounting for 48% of the studies. The results showed that (1) all commercial tests provided highly variable estimates of sensitivity (range 0.00-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (2) the Anda-TB IgG kit showed highly variable sensitivity (range 0.26-1.00) and specificity (range 0.59-1.00) for all extrapulmonary sites combined; (3) for all tests combined, sensitivity estimates for both lymph node tuberculosis (range 0.23-1.00) and pleural tuberculosis (range 0.26-0.59) were poor and inconsistent; and (4) there were no data to determine the accuracy of the tests in children or in patients with HIV infection, the two groups for which the test would be most useful. At present, commercial antibody detection tests for extrapulmonary tuberculosis have no role in clinical care or case detection. JF - Postgraduate Medical Journal AU - Steingart, Karen R AU - Henry, Megan AU - Laal, Suman AU - Hopewell, Philip C AU - Ramsay, Andrew AU - Menzies, Dick AU - Cunningham, Jane AU - Weldingh, Karin AU - Pai, Madhukar AD - Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, and Francis J Curry National Tuberculosis Center, San Francisco, California, USA County of Sacramento Department of Health and Human Services, Sacramento, California, USA Veterans Affairs Medical Center and Departments of Pathology and Microbiology, New York University School of Medicine, New York, USA UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada Statens Serum Institut, Department of Infectious Disease Immunology, Copenhagen S, Denmark Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 705 EP - 712 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 83 IS - 985 SN - 0032-5473, 0032-5473 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Human immunodeficiency virus KW - Immunoglobulin G KW - Tuberculosis KW - Infection KW - Children KW - Lymph nodes KW - J 02310:Genetics & Taxonomy KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20527752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+Medical+Journal&rft.atitle=A+systematic+review+of+commercial+serological+antibody+detection+tests+for+the+diagnosis+of+extrapulmonary+tuberculosis&rft.au=Steingart%2C+Karen+R%3BHenry%2C+Megan%3BLaal%2C+Suman%3BHopewell%2C+Philip+C%3BRamsay%2C+Andrew%3BMenzies%2C+Dick%3BCunningham%2C+Jane%3BWeldingh%2C+Karin%3BPai%2C+Madhukar&rft.aulast=Steingart&rft.aufirst=Karen&rft.date=2007-11-01&rft.volume=83&rft.issue=985&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Postgraduate+Medical+Journal&rft.issn=00325473&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immunoglobulin G; Tuberculosis; Children; Infection; Lymph nodes; Human immunodeficiency virus ER - TY - JOUR T1 - Effects on Outpatient and Emergency Mental Health Care of Strict Medicaid Early Periodic Screening, Diagnosis, and Treatment Enforcement AN - 20521864; 7928520 AB - We investigated enforcement of mental health benefits provided by California Medicaid's Early Periodic Screening, Diagnosis, and Treatment (EPSDT) program. Enforcement, compelled by a consumer-driven lawsuit, resulted in an almost 4-fold funding increase over a 5-year period. We evaluated the impact of enforcement on outpatient treatment intensity (number of visits per child) and rates of emergency care treatment. Using fixed-effects regression, we examined the number of outpatient mental health visits per client and the percentage of all clients using crisis care across 53 autonomous California county mental health plans over 32 three-month periods (quarters; emergency crisis care rates) and 36 quarters (out-patient mental health visits). Enforcement of EPSDT benefits in accordance with federal law produced favorable changes in patterns of mental health service use, consistent with policy aims. JF - American Journal of Public Health AU - Snowden, Lonnie R AU - Masland, Mary C AU - Wallace, Neal T AU - Evans-Cuellar, Allison AD - Lonnie R. Snowden is with the School of Social Welfare and the Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, Berkeley. Mary C. Masland is with the Center for Mental Health Services Research, Institute of Personality and Social Research, University of California, Berkeley. Neal T. Wallace is with the Division of Public Administration, Mark O. Hatfield School of Government, Portland State University, Portland, Ore. Allison Evans-Cuellar is with the Department of Health Policy and Management, Joseph P. Mailman School of Public Health, Columbia University, New York, NY Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1951 EP - 1956 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 11 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20521864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Effects+on+Outpatient+and+Emergency+Mental+Health+Care+of+Strict+Medicaid+Early+Periodic+Screening%2C+Diagnosis%2C+and+Treatment+Enforcement&rft.au=Snowden%2C+Lonnie+R%3BMasland%2C+Mary+C%3BWallace%2C+Neal+T%3BEvans-Cuellar%2C+Allison&rft.aulast=Snowden&rft.aufirst=Lonnie&rft.date=2007-11-01&rft.volume=97&rft.issue=11&rft.spage=1951&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Improved BLAST searches using longer words for protein seeding AN - 20498081; 7929366 AB - MOTIVATION: The blastp and tblastn modules of BLAST are widely used methods for searching protein queries against protein and nucleotide databases, respectively. One heuristic used in BLAST is to consider only database sequences that contain a high-scoring match of length at most 5 to the query. We implemented the capability to use words of length 6 or 7. We demonstrate an improved trade-off between running time and retrieval accuracy, controlled by the score threshold used for