TY - JOUR T1 - Nonfatal work-related motor vehicle injuries treated in emergency departments in the United States, 1998-2002 AN - 745631542; 12739844 AB - Background Current data on nonfatal work-related motor vehicle injuries are limited and fragmented, often excluding government workers, self-employed workers, and workers on small farms. This study seeks to bridge the present data gap by providing a national profile of nonfatal work-related motor vehicle injuries across all industries and occupations. Methods Study subjects were people who suffered nonfatal work-related motor vehicle injuries and were treated in a hospital emergency department in the United States. Subjects were identified from a stratified probability sample of emergency departments. National estimates and rates were computed. Results From 1998 to 2002, the average annual rate of nonfatal work-related motor vehicle injuries was 7 injuries per 10,000 full-time equivalents. The rate was three times higher in men than in women. The rates were higher in workers 15-19 years of age and in workers 70 years or older. Justice, public order, and safety workers had the largest number of injuries, and taxicab service employees had the highest injury rate of all industries. Truck drivers had the largest number of injuries, and police and detectives, public service employees had the highest injury rate of all occupations. Conclusion Future efforts need to develop and enhance the use of surveillance information at the federal and state level for work-related nonfatal motor vehicle injuries. Prevention efforts need to address occupational motor vehicle safety for both commercial truck/bus drivers and workers who are not commercial drivers but who drive light motor vehicles on the job. Am. J. Ind. Med. 52:698-706, 2009. JF - American Journal of Industrial Medicine AU - Chen, Guang X AD - Analysis and Field Operations Branch, Division of Safety Research, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, gchen@cdc.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 698 EP - 706 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 52 IS - 9 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - USA KW - Age KW - Injuries KW - police KW - Motor vehicles KW - Occupational safety KW - prevention KW - Trucks KW - emergency medical services KW - small farms KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745631542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Nonfatal+work-related+motor+vehicle+injuries+treated+in+emergency+departments+in+the+United+States%2C+1998-2002&rft.au=Chen%2C+Guang+X&rft.aulast=Chen&rft.aufirst=Guang&rft.date=2009-01-01&rft.volume=52&rft.issue=9&rft.spage=698&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20726 L2 - http://www3.interscience.wiley.com/journal/122514405/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; police; Injuries; Motor vehicles; Occupational safety; prevention; Trucks; small farms; emergency medical services; USA DO - http://dx.doi.org/10.1002/ajim.20726 ER - TY - JOUR T1 - Is There Evidence for Synergy Among Air Pollutants in Causing Health Effects? AN - 743484071; 201004-31-0316667 (CE); 12129476 (EN) AB - BACKGROUND: Environmental air pollutants are inhaled as complex mixtures, but the long dominant focus of monitoring and research on individual pollutants has provided modest insight into pollutant interactions that may be important to health. Trends toward managing multiple pollutants to maximize aggregate health gains place increasing value on knowing whether the effects of combinations of pollutants are greater than the sum of the effects of individual pollutants (synergy). OBJECTIVE: We reviewed selected published literature to determine whether synergistic effects of combinations of pollutants on health outcomes have actually been demonstrated. METHODS AND RESULTS: We reviewed 36 laboratory studies of combinations of ozone with other pollutants that were reported in the recent U.S. Environmental Protection Agency Ozone Criteria Document. We examined original reports to determine whether the experimental design tested for synergy and whether synergy was demonstrated. Fourteen studies demonstrated synergism, although synergistic, additive, and antagonistic effects were sometimes observed among different outcomes or at different times after exposure. CONCLUSIONS: Synergisms involving O3 have been demonstrated by laboratory studies of humans and animals. We conclude that the plausibility of synergisms among environmental pollutants has been established, although comparisons are limited, and most involved exposure concentrations much higher than typical of environmental pollutants. Epidemiologic research has limited ability to address the issue explicitly. JF - Environmental Health Perspectives AU - Mauderly, Joe L AU - Samet, Jonathan M PY - 2009 SP - 1 EP - 6 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Pollutants KW - Health KW - Ozone KW - Monitoring KW - Copyrights KW - Gain KW - Human KW - Aggregates KW - Criteria KW - Synergistic effect KW - Epidemiology KW - Trends KW - Additives KW - Animals KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743484071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Is+There+Evidence+for+Synergy+Among+Air+Pollutants+in+Causing+Health+Effects%3F&rft.au=Mauderly%2C+Joe+L%3BSamet%2C+Jonathan+M&rft.aulast=Mauderly&rft.aufirst=Joe&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Retrospective Performance Assessment of the Developmental Neurotoxicity Study in Support of OECD Test Guideline 426 AN - 743431089; 201004-31-0316668 (CE); 12129477 (EN) AB - OBJECTIVE: We conducted a review of the history and performance of developmental neurotoxicity (DNT) testing in support of the finalization and implementation of Organisation of Economic Co-operation and Development (OECD) DNT test guideline 426 (TG 426). INFORMATION SOURCES AND ANALYSIS: In this review we summarize extensive scientific efforts that form the foundation for this testing paradigm, including basic neurotoxicology research, interlaboratory collaborative studies, expert workshops, and validation studies, and we address the relevance, applicability, and use of the DNT study in risk assessment. CONCLUSIONS: The OECD DNT guideline represents the best available science for assessing the potential for DNT in human health risk assessment, and data generated with this protocol are relevant and reliable for the assessment of these end points. The test methods used have been subjected to an extensive history of international validation, peer review, and evaluation, which is contained in the public record. The reproducibility, reliability, and sensitivity of these methods have been demonstrated, using a wide variety of test substances, in accordance with OECD guidance on the validation and international acceptance of new or updated test methods for hazard characterization. Multiple independent, expert scientific peer reviews affirm these conclusions. JF - Environmental Health Perspectives AU - Makris, Susan L AU - Raffaele, Kathleen AU - Allen, Sandra AU - Bowers, Wayne J AU - Hass, Ulla AU - Alleva, Enrico AU - Calamandrei, Gemma AU - Sheets, Larry AU - Amcoff, Patric AU - Delrue, Nathalie AU - Crofton, Kevin M PY - 2009 SP - 17 EP - 25 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Guidelines KW - Health KW - Risk assessment KW - Acceptance tests KW - Copyrights KW - Reproducibility KW - Assessments KW - Economics KW - Human KW - Workshops KW - Foundations KW - Performance assessment KW - Acceptance KW - Cobalt KW - Interlaboratory KW - Information sources KW - Hazards KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743431089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Retrospective+Performance+Assessment+of+the+Developmental+Neurotoxicity+Study+in+Support+of+OECD+Test+Guideline+426&rft.au=Makris%2C+Susan+L%3BRaffaele%2C+Kathleen%3BAllen%2C+Sandra%3BBowers%2C+Wayne+J%3BHass%2C+Ulla%3BAlleva%2C+Enrico%3BCalamandrei%2C+Gemma%3BSheets%2C+Larry%3BAmcoff%2C+Patric%3BDelrue%2C+Nathalie%3BCrofton%2C+Kevin+M&rft.aulast=Makris&rft.aufirst=Susan&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Phthalates Impair Germ Cell Development in the Human Fetal Testis in Vitro without Change in Testosterone Production AN - 743370701; 201004-31-0316669 (CE); 12129478 (EN) AB - BACKGROUND: Several studies have described an increasing frequency of male reproductive disorders, which may have a common origin in fetal life and which are hypothesized to be caused by endocrine disruptors. Phthalate esters represent a class of environmental endocrine-active chemicals known to disrupt development of the male reproductive tract by decreasing testosterone production in the fetal rat. OBJECTIVES: Using the organ culture system we developed previously, we investigated the effects on the development of human fetal testis of one phthalate--mono-2-ethylhexyl phthalate (MEHP)--an industrial chemical found in many products, which has been incriminated as a disruptor of male reproductive function. METHODS: Human fetal testes were recovered during the first trimester (7-12 weeks) of gestation, a critical period for testicular differentiation, and cultured for 3 days with or without MEHP in basal conditions or stimulated with luteinizing hormone (LH). RESULTS: Whatever the dose, MEHP treatment had no effect on basal or LH-stimulated testosterone produced by the human fetal testis in vitro, although testosterone production can be modulated in our culture system. MEHP (10(-4) M) did not affect proliferation or apoptosis of Sertoli cells, but it reduced the mRNA expression of anti-Muellerian hormone. MEHP (10(-4) M) reduced the number of germ cells by increasing their apoptosis, measured by the detection of caspase-3-positive germ cells, without modification of their proliferation. CONCLUSIONS: This is the first experimental demonstration that phthalates alter the development of the germ cell lineage in humans. However, in contrast to results observed in the rat, phthalates did not affect steroidogenesis. JF - Environmental Health Perspectives AU - Lambrot, Romain AU - Muczynski, Vincent AU - Lecureuil, Charlotte AU - Angenard, Gaelle AU - Coffigny, Herve AU - Pairault, Catherine AU - Moison, Delphine AU - Frydman, Rene AU - Habert, Rene AU - Rouiller-Fabre, Virginie PY - 2009 SP - 32 EP - 37 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Human KW - Phthalates KW - Testosterone KW - Males KW - Gestation KW - Apoptosis KW - In vitro testing KW - Culture KW - Hormones KW - Health KW - Reproductive disorders KW - Esters KW - Endocrine disruptors KW - Differentiation KW - Origins KW - Copyrights KW - Testes KW - Organs KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743370701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Phthalates+Impair+Germ+Cell+Development+in+the+Human+Fetal+Testis+in+Vitro+without+Change+in+Testosterone+Production&rft.au=Lambrot%2C+Romain%3BMuczynski%2C+Vincent%3BLecureuil%2C+Charlotte%3BAngenard%2C+Gaelle%3BCoffigny%2C+Herve%3BPairault%2C+Catherine%3BMoison%2C+Delphine%3BFrydman%2C+Rene%3BHabert%2C+Rene%3BRouiller-Fabre%2C+Virginie&rft.aulast=Lambrot&rft.aufirst=Romain&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - One-Month Diesel Exhaust Inhalation Produces Hypertensive Gene Expression Pattern in Healthy Rats AN - 743341414; 201004-31-0316664 (CE); 12129473 (EN) AB - BACKGROUND: Exposure to diesel exhaust (DE) is linked to vasoconstriction, endothelial dysfunction, and myocardial ischemia in compromised individuals. OBJECTIVE: We hypothesized that DE inhalation would cause greater inflammation, hematologic alterations, and cardiac molecular impairment in spontaneously hypertensive (SH) rats than in healthy Wistar Kyoto (WKY) rats. METHODS AND RESULTS: Male rats (12-14 weeks of age) were exposed to air or DE from a 30-kW Deutz engine at 500 or 2,000 microg/m3, 4 hr/day, 5 days/week for 4 weeks. Neutrophilic influx was noted in the lung lavage fluid of both strains, but injury markers were minimally changed. Particle-laden macrophages were apparent histologically in DE-exposed rats. Lower baseline cardiac anti-oxidant enzyme activities were present in SH than in WKY rats; however, no DE effects were noted. Cardiac mitochondrial aconitase activity decreased after DE exposure in both strains. Electron microscopy indicated abnormalities in cardiac mitochondria of control SH but no DE effects. Gene expression profiling demonstrated alterations in 377 genes by DE in WKY but none in SH rats. The direction of DE-induced changes in WKY mimicked expression pattern of control SH rats without DE. Most genes affected by DE were down-regulated in WKY. The same genes were down-regulated in SH without DE producing a hypertensive-like expression pattern. The down-regulated genes included those that regulate compensatory response, matrix metabolism, mitochondrial function, and oxidative stress response. No up-regulation of inflammatory genes was noted. CONCLUSIONS: We provide the evidence that DE inhalation produces a hypertensive-like cardiac gene expression pattern associated with mitochondrial oxidative stress in healthy rats. JF - Environmental Health Perspectives AU - Gottipolu, Reddy R AU - Wallenborn, J Grace AU - Karoly, Edward D AU - Schladweiler, Mette C AU - Ledbetter, Allen D AU - Krantz, Todd AU - Linak, William P AU - Nyska, Abraham AU - Johnson, Jo Anne AU - Thomas, Ronald AU - Richards, Judy E AU - Jaskot, Richard H AU - Kodavanti, Urmila P PY - 2009 SP - 38 EP - 46 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Rats KW - Genes KW - Gene expression KW - Inhalation KW - Diesel KW - Diesel fuels KW - Health KW - Strain KW - Exhaust KW - Alterations KW - Stresses KW - Impairment KW - Vasoconstriction KW - Mitochondria KW - Ischemia KW - Markers KW - Fluid dynamics KW - Fluid flow KW - Macrophages KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743341414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=One-Month+Diesel+Exhaust+Inhalation+Produces+Hypertensive+Gene+Expression+Pattern+in+Healthy+Rats&rft.au=Gottipolu%2C+Reddy+R%3BWallenborn%2C+J+Grace%3BKaroly%2C+Edward+D%3BSchladweiler%2C+Mette+C%3BLedbetter%2C+Allen+D%3BKrantz%2C+Todd%3BLinak%2C+William+P%3BNyska%2C+Abraham%3BJohnson%2C+Jo+Anne%3BThomas%2C+Ronald%3BRichards%2C+Judy+E%3BJaskot%2C+Richard+H%3BKodavanti%2C+Urmila+P&rft.aulast=Gottipolu&rft.aufirst=Reddy&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Effect of Calcium Supplementation on Blood Lead Levels in Pregnancy: A Randomized Placebo-Controlled Trial AN - 743196235; 201004-31-0316666 (CE); 12129475 (EN) AB - BACKGROUND: Prenatal lead exposure is associated with deficits in fetal growth and neurodevelopment. Calcium supplementation may attenuate fetal exposure by inhibiting mobilization of maternal bone lead and/or intestinal absorption of ingested lead. OBJECTIVE: Our goal was to evaluate the effect of 1,200 mg dietary calcium supplementation on maternal blood lead levels during pregnancy. METHODS: In a double-blind, randomized, placebo-controlled trial conducted from 2001 through 2003 in Mexico City, we randomly assigned 670 women in their first trimester of pregnancy to ingest calcium (n = 334) or placebo (n = 336). We followed subjects through pregnancy and evaluated the effect of supplementation on maternal blood lead, using an intent-to-treat analysis by a mixed-effects regression model with random intercept, in 557 participants (83%) who completed follow-up. We then conducted as-treated analyses using similar models stratified by treatment compliance. RESULTS: Adjusting for baseline lead level, age, trimester of pregnancy, and dietary energy and calcium intake, calcium was associated with an average 11% reduction (0.4 microg/dL) in blood lead level relative to placebo (p = 0.004). This reduction was more evident in the second trimester (-14%, p 0.001) than in the third (-8%, p = 0.107) and was strongest in women who were most compliant (those who consumed or = 75% calcium pills; -24%, p 0.001), had baseline blood lead 5 microg/dL (-17%, p 0.01), or reported use of lead-glazed ceramics and high bone lead (-31%, p 0.01). CONCLUSION: Calcium supplementation was associated with modest reductions in blood lead when administered during pregnancy and may constitute an important secondary prevention effort to reduce circulating maternal lead and, consequently, fetal exposure. JF - Environmental Health Perspectives AU - Ettinger, Adrienne S AU - Lamadrid-Figueroa, Hector AU - Tellez-Rojo, Martha M AU - Mercado-Garcia, Adriana AU - Peterson, Karen E AU - Schwartz, Joel AU - Hu, Howard AU - Hernandez-Avila, Mauricio PY - 2009 SP - 26 EP - 31 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Calcium KW - Blood KW - Pregnancy KW - Reduction KW - Bones KW - Regression analysis KW - Health KW - Intakes KW - Attenuation KW - Circulating KW - Regression KW - Ceramics KW - Copyrights KW - Consumption KW - Pills KW - Mathematical models KW - Age KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743196235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Effect+of+Calcium+Supplementation+on+Blood+Lead+Levels+in+Pregnancy%3A+A+Randomized+Placebo-Controlled+Trial&rft.au=Ettinger%2C+Adrienne+S%3BLamadrid-Figueroa%2C+Hector%3BTellez-Rojo%2C+Martha+M%3BMercado-Garcia%2C+Adriana%3BPeterson%2C+Karen+E%3BSchwartz%2C+Joel%3BHu%2C+Howard%3BHernandez-Avila%2C+Mauricio&rft.aulast=Ettinger&rft.aufirst=Adrienne&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Prenatal Exposure to Polychlorinated Biphenyls: A Neuropsychologic Analysis AN - 743073127; 201004-31-0316665 (CE); 12129474 (EN) AB - OBJECTIVES: A large body of literature documents the effects of prenatal exposure to polychlorinated biphenyls (PCBs) on cognitive development of children. Despite this fact, no integrative synthesis has been published yet to identify the cognitive functions that are particularly affected. Our aim is to review this literature in an attempt to identify the cognitive profile associated with prenatal PCB exposure. DATA SOURCES: Studies were identified by searching the PubMed database for articles published before June 2008. We reviewed data from nine prospective longitudinal birth cohorts for different aspects of cognition. DATA EXTRACTION: Associations between indicators of prenatal PCB exposure and performance on cognitive tasks reported in the selected studies are summarized and classified as general cognitive abilities, verbal or visual-spatial skills, memory, attention, and executive functions. DATA SYNTHESIS: The most consistent effects observed across studies are impaired executive functioning related to increased prenatal PCB exposure. Negative effects on processing speed, verbal abilities, and visual recognition memory are also reported by most studies. Converging results from different cohort studies in which exposure arises from different sources make it unlikely that co-exposure with another associated contaminant is responsible for the observed effects. CONCLUSION: Prenatal PCB exposure appears to be related to a relatively specific cognitive profile of impairments. Failure to assess functions that are specifically impaired may explain the absence of effects found in some studies. Our findings have implications in the selection of cognitive assessment methods in future studies. JF - Environmental Health Perspectives AU - Boucher, Olivier AU - Muckle, Gina AU - Bastien, Celyne H PY - 2009 SP - 7 EP - 16 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Circuit boards KW - Printed circuits KW - Health KW - Synthesis KW - Polychlorinated biphenyls KW - Databases KW - Searching KW - Cognitive tasks KW - Assessments KW - Failure KW - Cognition KW - Impairment KW - Extraction KW - Contaminants KW - Children KW - Data sources KW - Recognition KW - Indicators KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743073127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prenatal+Exposure+to+Polychlorinated+Biphenyls%3A+A+Neuropsychologic+Analysis&rft.au=Boucher%2C+Olivier%3BMuckle%2C+Gina%3BBastien%2C+Celyne+H&rft.aulast=Boucher&rft.aufirst=Olivier&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Gene by environment interaction in asthma. AN - 67595808; 18980546 AB - Marked international differences in rates of asthma and allergies and the importance of family history highlight the primacy of interactions between genetic variation and the environment in asthma etiology. Environmental tobacco smoke (or secondhand smoke), ambient air pollutants, and endotoxin and/or other pathogen-associated molecular patterns are the ambient exposures studied most frequently for interactions with genetic polymorphisms in asthma. To date, results from the literature remain inconclusive. Most published studies are underpowered to study interactions between genetic polymorphisms and ambient exposures, each with weak effects. Strategies to increase power include cooperation across studies to increase sample sizes and improve measures of both exposure and asthma phenotypes. Genome-wide association studies hold promise for identifying unexpected gene environment interactions, but given the statistical power issues, candidate gene association studies will remain important. New tools are enabling the study of epigenetic mechanisms for environmental interactions. JF - Annual review of public health AU - London, Stephanie J AU - Romieu, Isabelle AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. london2@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 55 EP - 80 VL - 30 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Respiratory Function Tests KW - Genotype KW - Risk Factors KW - Humans KW - Methylation KW - Asthma -- epidemiology KW - Polymorphism, Genetic KW - Asthma -- blood KW - Asthma -- genetics KW - Tobacco Smoke Pollution -- adverse effects KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67595808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+public+health&rft.atitle=Gene+by+environment+interaction+in+asthma.&rft.au=London%2C+Stephanie+J%3BRomieu%2C+Isabelle&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2009-01-01&rft.volume=30&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+public+health&rft.issn=1545-2093&rft_id=info:doi/10.1146%2Fannurev.publhealth.031308.100151 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-08 N1 - Date created - 2009-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1146/annurev.publhealth.031308.100151 ER - TY - JOUR T1 - Effects of cooperating and conflicting cues on speech intonation recognition by cochlear implant users and normal hearing listeners. AN - 67488152; 19372651 AB - Cochlear implant (CI) recipients have only limited access to fundamental frequency (F0) information, and thus exhibit deficits in speech intonation recognition. For speech intonation, F0 serves as the primary cue, and other potential acoustic cues (e.g. intensity properties) may also contribute. This study examined the effects of cooperating or conflicting acoustic cues on speech intonation recognition by adult CI and normal hearing (NH) listeners with full-spectrum and spectrally degraded speech stimuli. Identification of speech intonation that signifies question and statement contrasts was measured in 13 CI recipients and 4 NH listeners, using resynthesized bi-syllabic words, where F0 and intensity properties were systematically manipulated. The stimulus set was comprised of tokens whose acoustic cues (i.e. F0 contour and intensity patterns) were either cooperating or conflicting. Subjects identified if each stimulus is a 'statement' or a 'question' in a single-interval, 2-alternative forced-choice (2AFC) paradigm. Logistic models were fitted to the data, and estimated coefficients were compared under cooperating and conflicting conditions, between the subject groups (CI vs. NH), and under full-spectrum and spectrally degraded conditions for NH listeners. The results indicated that CI listeners' intonation recognition was enhanced by cooperating F0 contour and intensity cues, but was adversely affected by these cues being conflicting. On the other hand, with full-spectrum stimuli, NH listeners' intonation recognition was not affected by cues being cooperating or conflicting. The effects of cues being cooperating or conflicting were comparable between the CI group and NH listeners with spectrally degraded stimuli. These findings suggest the importance of taking multiple acoustic sources for speech recognition into consideration in aural rehabilitation for CI recipients. Copyright (C) 2009 S. Karger AG, Basel. JF - Audiology & neuro-otology AU - Peng, Shu-Chen AU - Lu, Nelson AU - Chatterjee, Monita AD - Center for Device and Radiological Health, US Food and Drug Administration, Rockville, MD, USA. speng@hesp.umd.edu Y1 - 2009 PY - 2009 DA - 2009 SP - 327 EP - 337 VL - 14 IS - 5 KW - Index Medicus KW - Young Adult KW - Logistic Models KW - Aged, 80 and over KW - Humans KW - Adult KW - Noise KW - Aged KW - Speech Reception Threshold Test KW - Middle Aged KW - Acoustic Stimulation KW - Psychometrics KW - Male KW - Female KW - Speech Perception KW - Hearing Loss -- rehabilitation KW - Hearing Loss -- physiopathology KW - Phonetics KW - Hearing KW - Cochlear Implants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67488152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Audiology+%26+neuro-otology&rft.atitle=Effects+of+cooperating+and+conflicting+cues+on+speech+intonation+recognition+by+cochlear+implant+users+and+normal+hearing+listeners.&rft.au=Peng%2C+Shu-Chen%3BLu%2C+Nelson%3BChatterjee%2C+Monita&rft.aulast=Peng&rft.aufirst=Shu-Chen&rft.date=2009-01-01&rft.volume=14&rft.issue=5&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Audiology+%26+neuro-otology&rft.issn=1421-9700&rft_id=info:doi/10.1159%2F000212112 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-08 N1 - Date created - 2009-07-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Acoust Soc Am. 2000 Oct;108(4):1877-87 [11051514] Ear Hear. 2008 Jun;29(3):336-51 [18344873] J Acoust Soc Am. 2001 Aug;110(2):1150-63 [11519582] J Acoust Soc Am. 2002 May;111(5 Pt 1):2250-6 [12051445] J Acoust Soc Am. 2002 Nov;112(5 Pt 1):2155-64 [12430827] Ear Hear. 2004 Jun;25(3):251-64 [15179116] J Exp Child Psychol. 1984 Apr;37(2):231-50 [6726113] J Speech Hear Res. 1989 Jun;32(2):307-16 [2739382] J Acoust Soc Am. 1990 Jun;87(6):2592-605 [2373794] Percept Psychophys. 1991 Feb;49(2):187-200 [2017355] Phonetica. 1992;49(1):25-47 [1603839] Philos Trans R Soc Lond B Biol Sci. 1992 Jun 29;336(1278):367-73 [1354376] Science. 1995 Oct 13;270(5234):303-4 [7569981] J Acoust Soc Am. 1999 Mar;105(3):1889-900 [10089611] J Acoust Soc Am. 2004 Oct;116(4 Pt 1):2298-310 [15532661] J Assoc Res Otolaryngol. 2005 Mar;6(1):19-27 [15735937] J Acoust Soc Am. 2001 Feb;109(2):713-26 [11248975] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1159/000212112 ER - TY - JOUR T1 - EEG and cerebral blood flow velocity abnormalities in chronic cocaine users. AN - 67016958; 19278131 AB - EEG and cerebral blood flow abnormalities have been documented in chronic cocaine abusers. To identify possible relationships between EEG and blood flow changes and their relationship to the intensity of cocaine use, we recorded the resting eyes-closed EEG and anterior (ACA) and middle (MCA) cerebral artery blood flow velocity during systole (V(S)) and diastole (V(D)) by transcranial Doppler (TCD) sonography of 99 (76 male, 23 female; mean [SD] age 34.3 [5.2] years, 8.6 [5.5] years of cocaine use, 17.8 [7.7] days of cocaine use in month prior to screening) cocaine users within 5 days of admission to a closed research unit. Forty-two non-drug-using, age-matched control subjects (22 male, 20 female) were tested as outpatients. A 3-minute period of resting EEG was recorded from 16 standard scalp electrodes. Artifact-free EEG was converted to six frequency bands (delta, theta, alpha1, alpha2, beta1 and beta2) using a Fast Fourier Transform. Pulsatility index (PI) was calculated as a measure of small vessel resistance. Cocaine users had decreased VD and increased PI in the MCA, with no difference in V(S), and reduced EEG theta, beta1 and beta2 absolute power in posterior brain regions. Recent cocaine use was positively associated with MCA PI (r = 0.27, p < 0.001) and negatively associated with low frequency EEG power (delta power: r = -0.25, p < 0.002; theta power: r = -0.29, p < 0.001). EEG beta1 (r = -0.211, p < 0.05) and beta2 (r = -0.176, p < 0.05) power measures were correlated with PI. These observations suggest that EEG and TCD changes reflect related physiological processes during early cocaine abstinence. JF - Clinical EEG and neuroscience AU - Copersino, Marc L AU - Herning, Ronald I AU - Better, Warren AU - Cadet, Jean-Lud AU - Gorelick, David A AD - Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 39 EP - 42 VL - 40 IS - 1 SN - 1550-0594, 1550-0594 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Analysis of Variance KW - Blood Flow Velocity KW - Humans KW - Adult KW - Ultrasonography, Doppler, Transcranial KW - Cocaine -- toxicity KW - Fourier Analysis KW - Male KW - Female KW - Anterior Cerebral Artery -- drug effects KW - Brain -- blood supply KW - Brain -- drug effects KW - Electroencephalography KW - Anterior Cerebral Artery -- diagnostic imaging KW - Cerebrovascular Circulation KW - Middle Cerebral Artery -- diagnostic imaging KW - Cocaine-Related Disorders -- diagnostic imaging KW - Brain -- physiopathology KW - Middle Cerebral Artery -- physiopathology KW - Middle Cerebral Artery -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Anterior Cerebral Artery -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67016958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+EEG+and+neuroscience&rft.atitle=EEG+and+cerebral+blood+flow+velocity+abnormalities+in+chronic+cocaine+users.&rft.au=Copersino%2C+Marc+L%3BHerning%2C+Ronald+I%3BBetter%2C+Warren%3BCadet%2C+Jean-Lud%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2009-01-01&rft.volume=40&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Clinical+EEG+and+neuroscience&rft.issn=15500594&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-03 N1 - Date created - 2009-03-12 N1 - Date revised - 2017-02-15 N1 - SuppNotes - Cited By: Addict Behav. 1994 Nov-Dec;19(6):599-607 [7701971] J Nucl Med. 1995 Jul;36(7):1211-5 [7790946] J Neurosurg. 1996 Jan;84(1):79-84 [8613840] Psychiatry Res. 1995 Oct 16;58(3):247-57 [8570780] Epilepsia. 1996 Sep;37(9):875-8 [8814101] Biol Psychiatry. 1996 Nov 15;40(10):986-93 [8915557] Neurology. 1997 Feb;48(2):341-5 [9040718] Biol Psychiatry. 1997 Jun 1;41(11):1087-94 [9146819] Drug Alcohol Depend. 1997 Jun 6;46(1-2):87-93 [9246556] Neuropsychopharmacology. 1998 Jul;19(1):1-9 [9608571] Biol Psychiatry. 1999 May 1;45(9):1203-11 [10331113] J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):209-21 [10333992] Neuropsychopharmacology. 1999 Jul;21(1):110-8 [10379525] J Clin Neurophysiol. 2004 Sep-Oct;21(5):341-52 [15592008] Arch Gen Psychiatry. 2007 Apr;64(4):495-502 [17404126] Postgrad Med J. 2007 Jun;83(980):389-94 [17551070] Clin Neurophysiol. 2000 Apr;111(4):604-12 [10727911] Stroke. 2000 May;31(5):1111-5 [10797173] Neuropsychobiology. 2000;42(2):93-8 [10940764] Clin Neurophysiol. 2000 Nov;111(11):1961-7 [11068230] Neuropsychopharmacology. 2001 Sep;25(3):332-40 [11522462] Stroke. 2001 Oct;32(10):2338-43 [11588323] Epilepsia. 2002;43 Suppl 2:28-31 [11903480] Biol Psychiatry. 2002 Oct 15;52(8):831-42 [12372655] J Psychoactive Drugs. 2002 Oct-Dec;34(4):415-9 [12562110] Stroke. 2003 Jun;34(6):1375-81 [12764233] Radiology. 1990 Sep;176(3):821-4 [2389042] Am J Drug Alcohol Abuse. 1990;16(3-4):307-17 [2126913] Headache. 1991 Jan;31(1):17-9 [2016163] J Nucl Med. 1991 Jun;32(6):1206-10 [2045934] Psychiatry Res. 1990 Dec;35(2):95-105 [2100807] J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):803-6 [1955899] J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):419-27 [8286941] J Nucl Med. 1994 Dec;35(12):1902-9 [7989967] Neuropsychobiology. 1994;30(4):189-96 [7862268] N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Hyperthermia increases the cytotoxicity of many exogenous compounds. AN - 66914669; 19215178 AB - Cytotoxicity testing of extracts from medical device materials is typically conducted at 37 degrees C. It may be more relevant to screen extracts from device materials for in vitro cytotoxicity at temperatures found in febrile patients. To address this, the cytotoxicity of selected chemicals, drugs, and medical device extracts was evaluated in vitro following incubation at normothermic (37 degrees C) and hyperthermic (39 degrees C) conditions. In L929 cells, the percentage of cell death increased from 2-fold to more than 4-fold after chemical exposure when cells were maintained at 39 degrees C. Extracts of some medical devices and materials showed a 10-fold increase in cytotoxicity when cells were maintained at 39 degrees C as compared to 37 degrees C. For many of the substances in this study, exogenous compounds that are toxic at normothermic conditions (37 degrees C) are more cytotoxic under hyperthermic conditions (39 degrees C). The toxicity of compounds was more readily discernable at the higher incubation temperature, even at lower concentrations. In vitro cytotoxicity testing of chemicals and extracts at febrile temperatures can provide more sensitive and relevant biocompatibility tests than under normothermic conditions alone. JF - Biomedical instrumentation & technology AU - Lucas, Anne D AU - Lappalainen, Sharon K AU - Wray-Cahen, Diane AD - US Food and Drug Administration, Center for Device and Radiological Health, Silver Spring, MD 20903, USA. anne.lucas@fda.hhs.gov PY - 2009 SP - 73 EP - 79 VL - 43 IS - 1 SN - 0899-8205, 0899-8205 KW - Metals KW - 0 KW - Organic Chemicals KW - Pharmaceutical Preparations KW - Index Medicus KW - Animals KW - Humans KW - Jurkat Cells KW - Mice KW - Cell Line KW - Pharmaceutical Preparations -- administration & dosage KW - Hot Temperature KW - Fibroblasts -- drug effects KW - Metals -- administration & dosage KW - Organic Chemicals -- administration & dosage KW - Apoptosis -- drug effects KW - Fibroblasts -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66914669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+instrumentation+%26+technology&rft.atitle=Hyperthermia+increases+the+cytotoxicity+of+many+exogenous+compounds.&rft.au=Lucas%2C+Anne+D%3BLappalainen%2C+Sharon+K%3BWray-Cahen%2C+Diane&rft.aulast=Lucas&rft.aufirst=Anne&rft.date=2009-01-01&rft.volume=43&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Biomedical+instrumentation+%26+technology&rft.issn=08998205&rft_id=info:doi/10.2345%2F0899-8205-43.1.73 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-19 N1 - Date created - 2009-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2345/0899-8205-43.1.73 ER - TY - JOUR T1 - Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. AN - 66852343; 18978339 AB - Benzene is an established human hematotoxicant and leukemogen but its mechanism of action is unclear. To investigate the role of single-nucleotide polymorphisms (SNPs) on benzene-induced hematotoxicity, we analyzed 1395 SNPs in 411 genes using an Illumina GoldenGate assay in 250 benzene-exposed workers and 140 unexposed controls. Highly significant findings clustered in five genes (BLM, TP53, RAD51, WDR79 and WRN) that play a critical role in DNA repair and genomic maintenance, and these regions were then further investigated with tagSNPs. One or more SNPs in each gene were associated with highly significant 10-20% reductions (P values ranged from 0.0011 to 0.0002) in the white blood cell (WBC) count among benzene-exposed workers but not controls, with evidence for gene-environment interactions for SNPs in BLM, WRN and RAD51. Further, among workers exposed to benzene, the genotype-associated risk of having a WBC count 8-fold. In vitro functional studies revealed that deletion of SGS1 in yeast, equivalent to lacking BLM and WRN function in humans, caused reduced cellular growth in the presence of the toxic benzene metabolite hydroquinone, and knockdown of WRN using specific short hairpin RNA increased susceptibility of human TK6 cells to hydroquinone toxicity. Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity. JF - Carcinogenesis AU - Lan, Qing AU - Zhang, Luoping AU - Shen, Min AU - Jo, William J AU - Vermeulen, Roel AU - Li, Guilan AU - Vulpe, Christopher AU - Lim, Sophia AU - Ren, Xuefeng AU - Rappaport, Stephen M AU - Berndt, Sonja I AU - Yeager, Meredith AU - Yuenger, Jeff AU - Hayes, Richard B AU - Linet, Martha AU - Yin, Songnian AU - Chanock, Stephen AU - Smith, Martyn T AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. qingl@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 50 EP - 58 VL - 30 IS - 1 KW - Benzene KW - J64922108F KW - Index Medicus KW - Occupational Exposure KW - Polymorphism, Single Nucleotide KW - Humans KW - DNA Repair KW - Benzene -- toxicity KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66852343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Large-scale+evaluation+of+candidate+genes+identifies+associations+between+DNA+repair+and+genomic+maintenance+and+development+of+benzene+hematotoxicity.&rft.au=Lan%2C+Qing%3BZhang%2C+Luoping%3BShen%2C+Min%3BJo%2C+William+J%3BVermeulen%2C+Roel%3BLi%2C+Guilan%3BVulpe%2C+Christopher%3BLim%2C+Sophia%3BRen%2C+Xuefeng%3BRappaport%2C+Stephen+M%3BBerndt%2C+Sonja+I%3BYeager%2C+Meredith%3BYuenger%2C+Jeff%3BHayes%2C+Richard+B%3BLinet%2C+Martha%3BYin%2C+Songnian%3BChanock%2C+Stephen%3BSmith%2C+Martyn+T%3BRothman%2C+Nathaniel&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2009-01-01&rft.volume=30&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn249 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Biometrics. 1986 Mar;42(1):121-30 [3719049] Science. 2002 Jun 21;296(5576):2225-9 [12029063] J Biol Chem. 2002 Aug 30;277(35):31980-7 [12080066] Am J Ind Med. 2002 Oct;42(4):275-85 [12271475] Nat Rev Cancer. 2003 Mar;3(3):169-78 [12612652] Environ Health Perspect. 2003 Aug;111(11):1411-20 [12928149] Cancer Res. 2003 Nov 15;63(22):7657-62 [14633686] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003 Apr;21(2):86-9 [14761515] Br J Ind Med. 1987 Feb;44(2):124-8 [3814544] Cancer Res. 1990 Jun 1;50(11):3141-5 [2110504] Cancer Res. 1991 Nov 15;51(22):6094-7 [1933872] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Carcinogenesis. 1995 Nov;16(11):2841-6 [7586207] Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6236-40 [8692798] Am J Ind Med. 1996 Mar;29(3):236-46 [8833776] Eur J Haematol Suppl. 1996;60:111-8 [8987252] Environ Health Perspect. 1996 Dec;104 Suppl 6:1247-50 [9118900] Cancer Res. 1997 Jul 15;57(14):2839-42 [9230185] EMBO J. 1998 Jan 15;17(2):598-608 [9430650] Cancer Res. 1998 May 15;58(10):2176-81 [9605763] Carcinogenesis. 1998 Jun;19(6):973-8 [9667733] Mutat Res. 1998 Jul 17;403(1-2):65-73 [9726007] Genes Dev. 1999 Jun 1;13(11):1355-60 [10364153] J Biol Chem. 1999 Oct 8;274(41):29463-9 [10506209] Science. 2004 Dec 3;306(5702):1774-6 [15576619] Cancer Res. 2005 Oct 15;65(20):9152-4 [16230371] Cancer Res. 2005 Oct 15;65(20):9574-81 [16230423] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Carcinogenesis. 2006 Oct;27(10):2083-9 [16728435] Blood. 2006 Dec 1;108(12):3916-8 [16902145] J Med Genet. 2007 Jan;44(1):e61 [17209131] Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):270-5 [17301259] Adv Genet. 2007;58:67-87 [17452246] Genet Epidemiol. 2007 Sep;31(6):553-64 [17487883] Am J Hum Genet. 2007 Dec;81(6):1186-200 [17999359] Mutat Res. 2008 Jan 8;649(1-2):54-61 [17875398] Leuk Res. 2007 Feb;31(2):169-74 [16890287] Ann Occup Hyg. 2004 Mar;48(2):105-16 [14990432] Genes Chromosomes Cancer. 2004 Oct;41(2):109-16 [15287023] Stem Cells. 2004;22(5):750-8 [15342939] Trends Genet. 2000 Jun;16(6):259-64 [10827453] J Toxicol Environ Health A. 2000 Nov;61(5-6):357-72 [11086940] Biochemistry. 2000 Nov 28;39(47):14617-25 [11087418] Nat Genet. 2001 Jan;27(1):113-6 [11138010] Am J Ind Med. 2001 Aug;40(2):117-26 [11494338] Blood. 1978 Aug;52(2):285-92 [667356] Oncogene. 2002 Jun 6;21(25):4065-9 [12037689] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn249 ER - TY - JOUR T1 - Occupational factors and risk of preterm birth in nurses. AN - 66782029; 18976732 AB - We evaluated first-trimester exposures and the risk of preterm birth in the most recent pregnancy of participants of the Nurses' Health Study II. Log binomial regression was used to estimate the relative risk (RR) for preterm birth in relation to occupational risk factors, such as work schedule, physical factors, and exposures to chemicals and x-rays, adjusted for age and parity. Part-time work (2 years) infected in The Netherlands. Of all TB cases during the 12-year study period, 38% were infected in a foreign country, 36% resulted from recent transmission in The Netherlands, and 18% resulted from remote infection in The Netherlands, while in the remaining cases (9%) either the time or place of infection could not be determined. The conventional epidemiological data suggested that at least 29% of clustered cases were not part of recent chains of transmission. Cases with unknown fingerprints, almost all culture negative, relatively frequently had confirmed epidemiological links with a recent pulmonary TB case in The Netherlands and were more often identified by contact tracing. Our findings highlight the idea that genotyping should be combined with conventional epidemiological investigation to establish the place and time of infection of TB cases as accurately as possible. A standardized way of classifying TB into recently, remotely, and foreign-acquired disease provides indicators for surveillance and TB control program performance that can be used to decide on interventions and allocation of resources. JF - Journal of Clinical Microbiology AU - Vries, Gde AU - M Baars, HW AU - G. G. Sebek, MM AU - H van Hest, NA AU - Richardus, J H AD - Department of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, P.O. Box 70032, 3000 LP Rotterdam, The Netherlands, devriesg@ggd.rotterdam.nl Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 3924 EP - 3930 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 46 IS - 12 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - Mycobacterium KW - Genotyping KW - Control programs KW - Population studies KW - Infection KW - Contact tracing KW - Models KW - Classification KW - Lung KW - DNA KW - Tuberculosis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839684867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Transmission+Classification+Model+To+Determine+Place+and+Time+of+Infection+of+Tuberculosis+Cases+in+an+Urban+Area+%2C&rft.au=Vries%2C+Gde%3BM+Baars%2C+HW%3BG.+G.+Sebek%2C+MM%3BH+van+Hest%2C+NA%3BRichardus%2C+J+H&rft.aulast=Vries&rft.aufirst=Gde&rft.date=2008-12-01&rft.volume=46&rft.issue=12&rft.spage=3924&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00793-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Number of references - 37 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Data processing; Classification; Lung; Control programs; Genotyping; DNA; Population studies; Tuberculosis; Contact tracing; Infection; Models; Mycobacterium DO - http://dx.doi.org/10.1128/JCM.00793-08 ER - TY - JOUR T1 - Introduction to the Special Section: The Application of Effect Sizes in Research on Children and Families AN - 839580544; 201104097 AB - Effect sizes are increasingly used to describe the magnitude of findings about program effectiveness across a range of policy contexts. However, often, both researchers and policy makers could benefit from more information about the factors that affect the calculation and interpretation of these effect sizes. To address these issues, the Administration for Children and Families and federal partners convened a roundtable in 2007, entitled Application of Effect Sizes in Research on Children and Families. This special section includes articles from this roundtable that begin a focused discussion about the purposes, calculation, and interpretation of effect sizes. Adapted from the source document. JF - Child Development Perspectives AU - Supplee, Lauren H Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 164 EP - 166 PB - Wiley Publishing, Malden, MA 02148 VL - 2 IS - 3 SN - 1750-8592, 1750-8592 KW - effect sizes KW - methods KW - evidence-based practice KW - Policy makers KW - Magnitude KW - Evaluative research KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839580544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development+Perspectives&rft.atitle=Introduction+to+the+Special+Section%3A+The+Application+of+Effect+Sizes+in+Research+on+Children+and+Families&rft.au=Supplee%2C+Lauren+H&rft.aulast=Supplee&rft.aufirst=Lauren&rft.date=2008-12-01&rft.volume=2&rft.issue=3&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Child+Development+Perspectives&rft.issn=17508592&rft_id=info:doi/10.1111%2Fj.1750-8606.2008.00059.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Children; Policy makers; Magnitude; Evaluative research DO - http://dx.doi.org/10.1111/j.1750-8606.2008.00059.x ER - TY - JOUR T1 - Measuring Hospital Inefficiency: The Effects of Controlling for Quality and Patient Burden of Illness AN - 839575008; 201103046 AB - Objective: To assess the impact of employing a variety of controls for hospital quality and patient burden of illness on the mean estimated inefficiency and relative ranking of hospitals generated by stochastic frontier analysis (SFA). Study Setting: This study included urban U.S. hospitals in 20 states operating in 2001. Data Design/Data Collection: We took hospital data for 1,290 hospitals from the American Hospital Association Annual Survey and the Medicare Cost Reports. We employed a variety of controls for hospital quality and patient burden of illness. Among the variables we used were a subset of the quality indicators generated from the application of the Patient Safety Indicator and Inpatient Quality Indicator modules of the Agency for Healthcare Research and Quality, Quality Indicator software to the Healthcare Cost and Utilization Project (HCUP), State Inpatient Databases. Measures of a component of patient burden of illness came from the application of the Comorbidity Software to HCUP data. Data Analysis: We used SFA to estimate hospital cost-inefficiency. We tested key assumptions of the SFA model with likelihood ratio tests. Principal Findings: The measures produced by the Comorbidity Software appear to account for variations in patient burden of illness that had previously been masquerading as inefficiency. Outcome measures of quality can provide useful insight into a hospital's operations but may have little impact on estimated inefficiency once controls for structural quality and patient burden of illness have been employed. Conclusions: Choices about controlling for quality and patient burden of illness can have a nontrivial impact on mean estimated hospital inefficiency and the relative ranking of hospitals generated by SFA. Adapted from the source document. JF - Health Services Research AU - Mutter, Ryan L AU - Rosko, Michael D AU - Wong, Herbert S AD - Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, Rockville, MD Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1992 EP - 2013 PB - Blackwell Publishers, Oxford UK VL - 43 IS - 6 SN - 0017-9124, 0017-9124 KW - Hospital efficiency stochastic frontier analysis hospital quality patient safety KW - Quality of care KW - Hospitalization KW - Comorbidity KW - Quality management KW - Burden KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839575008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=Highly+Variable+Drugs%3A+Observations+from+Bioequivalence+Data+Submitted+to+the+FDA+for+New+Generic+Drug+Applications&rft.au=Davit%2C+Barbara+M%3BConner%2C+Dale+P%3BFabian-Fritsch%2C+Beth%3BHaidar%2C+Sam+H%3BJiang%2C+Xiaojian%3BPatel%2C+Devvrat+T%3BSeo%2C+Paul+R+H%3BSuh%2C+Keri%3BThompson%2C+Christina+L%3BYu%2C+Lawrence+X&rft.aulast=Davit&rft.aufirst=Barbara&rft.date=2008-03-01&rft.volume=10&rft.issue=1&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Fs12248-008-9015-x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Hospitals; Burden; Quality management; Comorbidity; Quality of care; Hospitalization DO - http://dx.doi.org/10.1111/j.1475-6773.2008.00892.x ER - TY - JOUR T1 - The Impact of Medical Errors on Ninety-Day Costs and Outcomes: An Examination of Surgical Patients AN - 839571168; 201101163 AB - Objective: To estimate the effect of medical errors on medical expenditures, death, readmissions, and outpatient care within 90 days after surgery. Data Sources: 2001-2002 MarketScan insurance claims for 5.6 million enrollees. Study Design: The Agency for Healthcare Research and Quality Patient Safety Indicators (PSIs) were used to identify 14 PSIs among 161,004 surgeries. We used propensity score matching and multivariate regression analyses to predict expenditures and outcomes attributable to the 14 PSIs. Principal Findings: Excess 90-day expenditures likely attributable to PSIs ranged from $646 for technical problems (accidental laceration, pneumothorax, etc.) to $28,218 for acute respiratory failure, with up to 20 percent of these costs incurred postdischarge. With a third of all 90-day deaths occurring postdischarge, the excess death rate associated with PSIs ranged from 0 to 7 percent. The excess 90-day readmission rate associated with PSIs ranged from 0 to 8 percent. Overall, 11 percent of all deaths, 2 percent of readmissions, and 2 percent of expenditures were likely due to these 14 PSIs. Conclusions: The effects of medical errors continue long after the patient leaves the hospital. Medical error studies that focus only on the inpatient stay can underestimate the impact of patient safety events by up to 20-30 percent. Adapted from the source document. JF - Health Services Research AU - Encinosa, William E AU - Hellinger, Fred J AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2067 EP - 2085 PB - Blackwell Publishers, Oxford UK VL - 43 IS - 6 SN - 0017-9124, 0017-9124 KW - Medical errors patient safety expenditures KW - Critical incidents KW - Death KW - Expenditure KW - Readmission KW - Surgery KW - Patient care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839571168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=The+Impact+of+Medical+Errors+on+Ninety-Day+Costs+and+Outcomes%3A+An+Examination+of+Surgical+Patients&rft.au=Encinosa%2C+William+E%3BHellinger%2C+Fred+J&rft.aulast=Encinosa&rft.aufirst=William&rft.date=2008-12-01&rft.volume=43&rft.issue=6&rft.spage=2067&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2008.00882.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Expenditure; Critical incidents; Death; Readmission; Patient care; Surgery DO - http://dx.doi.org/10.1111/j.1475-6773.2008.00882.x ER - TY - JOUR T1 - Ultrasonic attenuation in parallel-nylon-wire cancellous-bone-mimicking phantoms. AN - 742776754; pmid-19206826 AB - Attenuation coefficients between 1.5 and 3.5 MHz were measured on four parallel-nylon-wire arrays (simulating cancellous bone) with four different wire diameters (150, 200, 250, and 300 microm). Interwire spacing was 800 microm for all four parallel-nylon-wire arrays. The measured frequency dependencies of attenuation were consistent with theoretical predications based on Faran's theory, which considers the component of attenuation due to scattering of longitudinal waves. JF - The Journal of the Acoustical Society of America AU - Wear, Keith A AD - US Food and Drug Administration, Silver Spring, Maryland 20993, USA. keith.wear@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 4042 EP - 4046 VL - 124 IS - 6 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Models, Theoretical KW - Phantoms, Imaging KW - Ultrasonography -- instrumentation KW - Nylons KW - Bone and Bones -- ultrasonography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742776754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Performance+evaluation+of+cytometric+bead+assays+for+the+measurement+of+lung+cytokines+in+two+rodent+models&rft.au=Young%2C+SH%3BAntonini%2C+J+M%3BRoberts%2C+J+R%3BErdely%2C+AD%3BZeidler-Erdely%2C+P+C&rft.aulast=Young&rft.aufirst=SH&rft.date=2008-02-29&rft.volume=331&rft.issue=1-2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2007.11.004 LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area. AN - 733919692; 19046442 AB - The production and use of nanoparticles is growing rapidly due to the unique physical and chemical properties associated with their nano size and large surface area. Since nanoparticles have unique physicochemical properties, their bioactivity upon exposure to workers or consumers is of interest. In this study, the issue of what dose metric (mass dose versus surface area dose) is appropriate for toxicological studies has been addressed. Rats were exposed by intratracheal instillation to various doses of ultrafine or fine TiO2. At 1, 7, or 42 days post-exposure, inflammatory and cytotoxic potential of each particle type was compared on both a mass dosage (mg/rat) as well as an equal surface area dosage (cm2 of particles per cm2 of alveolar epithelium) basis. The findings of the study show that on a mass basis the ultrafine particles caused significantly more inflammation and were significantly more cytotoxic than the fine sized particles. However, when doses were equalized based on surface area of particles delivered, the ultrafine particles were only slightly more inflammogenic and cytotoxic when compared to the fine sized particles. Lung burden data indicate that ultrafine TiO2 appears to migrate to the interstitium to a much greater extent than fine TiO2. This study suggests that surface area of particles may be a more appropriate dose metric for pulmonary toxicity studies than mass of particles. JF - Particle and fibre toxicology AU - Sager, Tina M AU - Kommineni, C AU - Castranova, Vincent AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. vic1@cdc.gov. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 17 VL - 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733919692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Pulmonary+response+to+intratracheal+instillation+of+ultrafine+versus+fine+titanium+dioxide%3A+role+of+particle+surface+area.&rft.au=Sager%2C+Tina+M%3BKommineni%2C+C%3BCastranova%2C+Vincent&rft.aulast=Sager&rft.aufirst=Tina&rft.date=2008-12-01&rft.volume=5&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-5-17 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Inhal Toxicol. 1996;8 Suppl:73-89 [11542496] Methods Enzymol. 1987;154:498-511 [3431461] J Toxicol Environ Health A. 2002 Aug 23;65(16):1121-40 [12167212] Inhal Toxicol. 2007 Aug;19(10):849-56 [17687716] Fundam Appl Toxicol. 1988 Apr;10(3):369-84 [3286345] Occup Environ Med. 2007 Sep;64(9):609-15 [17409182] Inhal Toxicol. 2000 Jan-Feb;12(1-2):1-17 [10715616] J Am Chem Soc. 2002 Dec 25;124(51):15198-207 [12487595] Inhal Toxicol. 2000 Dec;12(12):1113-26 [11114784] Am J Respir Cell Mol Biol. 1992 May;6(5):535-42 [1581076] Environ Health Perspect. 1994 Oct;102 Suppl 5:173-9 [7882925] Methods Enzymol. 1986;132:498-507 [3821523] Environ Health Perspect. 2007 Mar;115(3):397-402 [17431489] Toxicology. 2007 Jan 25;230(1):90-104 [17196727] Toxicol Sci. 2006 May;91(1):227-36 [16495353] J Aerosol Med. 2002 Summer;15(2):213-20 [12184871] Toxicol Sci. 2006 Jul;92(1):174-85 [16613837] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1743-8977-5-17 ER - TY - JOUR T1 - Cumulative sensitization and disease in a beryllium oxide ceramics worker cohort. AN - 69904655; 19092488 AB - We followed a cohort of 136 beryllium oxide ceramics workers from 1992 to 2003, including those who left employment, for beryllium sensitization and chronic beryllium disease (CBD). We invited the cohort's participation in current worker surveys in 1992, 1998, 2000, and 2002-2003, and in former worker surveys in 2000-2001 and 2003. We calculated 11-year cumulative incidences (after 1992 initial survey) of sensitization and CBD, both crude and corrected for interval censoring; and period prevalences (including 1992 findings), crude and corrected. In 1992, point prevalences were 6% sensitized and 4% CBD. We obtained follow-up on 83% of 128 not sensitized in 1992. Crude cumulative incidences for sensitization and CBD were 13% and 9%, respectively; corrected were 15% and 11%. Crude period prevalences for sensitization and CBD were 16% and 11%, respectively; corrected were 20% and 14%. Corrected period prevalences for pre-1992 machining work were 30% and 20%. With repeated testing over 11 years, total sensitization and CBD in this cohort were triple initial 1992 survey results. JF - Journal of occupational and environmental medicine AU - Schuler, Christine R AU - Kitt, Margaret M AU - Henneberger, Paul K AU - Deubner, David C AU - Kreiss, Kathleen AD - Division of Respiratory Disease Studies, Field Studies Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WVa 26505, USA. christine.schuler@cdc.hhs.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1343 EP - 1350 VL - 50 IS - 12 KW - beryllium oxide KW - 2S8NLR37S3 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Bronchoscopes KW - Humans KW - Aged KW - Lymphocytes KW - Smoking -- epidemiology KW - Ceramics KW - Adult KW - Cohort Studies KW - Surveys and Questionnaires KW - Incidence KW - Middle Aged KW - Chronic Disease KW - Chemical Industry KW - Female KW - Male KW - Proportional Hazards Models KW - Hypersensitivity -- epidemiology KW - Berylliosis -- blood KW - Hypersensitivity -- etiology KW - Berylliosis -- epidemiology KW - Occupational Exposure -- adverse effects KW - Beryllium -- adverse effects KW - Beryllium -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69904655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Cumulative+sensitization+and+disease+in+a+beryllium+oxide+ceramics+worker+cohort.&rft.au=Schuler%2C+Christine+R%3BKitt%2C+Margaret+M%3BHenneberger%2C+Paul+K%3BDeubner%2C+David+C%3BKreiss%2C+Kathleen&rft.aulast=Schuler&rft.aufirst=Christine&rft.date=2008-12-01&rft.volume=50&rft.issue=12&rft.spage=1343&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=1536-5948&rft_id=info:doi/10.1097%2FJOM.0b013e31818def24 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2008-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JOM.0b013e31818def24 ER - TY - JOUR T1 - Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide. AN - 69872593; 18800343 AB - The discovery of acrylamide (AA) in a variety of fried foods has raised public health concerns. In this study, groups of male mice were administered 500 mg/L AA in drinking water for 3 weeks, and gene expression changes were evaluated in the livers of AA-treated mice within 24 hr of the last treatment. When a two-fold cutoff value and a P-value less than 0.05 were selected, 696 genes (233 up-regulated and 463 down-regulated) were identified as differentially expressed genes in AA-treated mice when compared with the controls. Gene ontology analysis revealed that the principle pathways affected by AA were xenobiotic metabolism by cytochrome P450 (CYPs) and glutathione metabolism, suggesting that drug and/or xenobiotic metabolism is most affected by exposure. The results provide more information about AA metabolism and further insight into the molecular mechanisms involved in AA-induced toxicity. JF - Environmental and molecular mutagenesis AU - Mei, Nan AU - Guo, Lei AU - Tseng, Jo AU - Dial, Stacey L AU - Liao, Wayne AU - Manjanatha, Mugimane G AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. nan.mei@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 741 EP - 745 VL - 49 IS - 9 KW - Xenobiotics KW - 0 KW - Acrylamide KW - 20R035KLCI KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Cytochrome P-450 Enzyme System -- genetics KW - Xenobiotics -- metabolism KW - Glutathione Transferase -- metabolism KW - Xenobiotics -- pharmacology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Mice KW - Glutathione Transferase -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Gene Expression -- drug effects KW - Gene Expression Profiling KW - Acrylamide -- metabolism KW - Acrylamide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69872593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Gene+expression+changes+associated+with+xenobiotic+metabolism+pathways+in+mice+exposed+to+acrylamide.&rft.au=Mei%2C+Nan%3BGuo%2C+Lei%3BTseng%2C+Jo%3BDial%2C+Stacey+L%3BLiao%2C+Wayne%3BManjanatha%2C+Mugimane+G&rft.aulast=Mei&rft.aufirst=Nan&rft.date=2008-12-01&rft.volume=49&rft.issue=9&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20429 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20429 ER - TY - JOUR T1 - Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. AN - 69860429; 18978633 AB - In response to previously published findings of methylphenidate-induced chromosomal changes in children, this study was designed to determine whether methylphenidate- or amphetamine-based drugs induce chromosomal damage (structural aberrations, micronuclei, and sister chromatid exchanges) in peripheral blood lymphocytes of children with attention-deficit/hyperactivity disorder after 3 months of continuous treatment. Stimulant drug-naïve subjects, 6 to 12 years of age, in good overall health, and judged to be appropriate candidates for stimulant therapy based on rigorously diagnosed ADHD using DSM-IV criteria, were randomized into two open-label treatment groups (methylphenidate or mixed amphetamine salts). Each subject provided a blood sample before initiation of treatment and after 3 months of treatment. Pretreatment and posttreatment frequencies of chromosomal aberrations, micronuclei, and sister chromatid exchanges were determined for each subject. Sixty-three subjects enrolled in the study; 47 subjects completed the full 3 months of treatment, 25 in the methylphenidate group and 22 in the amphetamine group. No significant treatment-related increases were observed in any of the three measures of cytogenetic damage in the 47 subjects who completed treatment or the 16 subjects who did not. Earlier findings of methylphenidate-induced chromosomal changes in children were not replicated in this study. These results add to the accumulating evidence that therapeutic levels of methylphenidate do not induce cytogenetic damage in humans. Furthermore, our results indicate that amphetamine-based products do not pose a risk for cytogenetic damage in children. JF - Journal of the American Academy of Child and Adolescent Psychiatry AU - Witt, Kristine L AU - Shelby, Michael D AU - Itchon-Ramos, Nilda AU - Faircloth, Melissa AU - Kissling, Grace E AU - Chrisman, Allan K AU - Ravi, Hima AU - Murli, Hemalatha AU - Mattison, Donald R AU - Kollins, Scott H AD - National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Triangle Park, NC 27709, USA. witt@niehs.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1375 EP - 1383 VL - 47 IS - 12 KW - Adderall KW - 0 KW - Amphetamines KW - Central Nervous System Stimulants KW - SLI381 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Lymphocytes -- metabolism KW - Child KW - Lymphocytes -- drug effects KW - Male KW - Female KW - Attention Deficit Disorder with Hyperactivity -- genetics KW - Micronucleus Tests KW - Amphetamines -- therapeutic use KW - Sister Chromatid Exchange KW - Central Nervous System Stimulants -- toxicity KW - Chromosome Aberrations KW - Methylphenidate -- therapeutic use KW - Central Nervous System Stimulants -- therapeutic use KW - Methylphenidate -- toxicity KW - Attention Deficit Disorder with Hyperactivity -- drug therapy KW - Amphetamines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69860429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+and+Adolescent+Psychiatry&rft.atitle=Methylphenidate+and+amphetamine+do+not+induce+cytogenetic+damage+in+lymphocytes+of+children+with+ADHD.&rft.au=Witt%2C+Kristine+L%3BShelby%2C+Michael+D%3BItchon-Ramos%2C+Nilda%3BFaircloth%2C+Melissa%3BKissling%2C+Grace+E%3BChrisman%2C+Allan+K%3BRavi%2C+Hima%3BMurli%2C+Hemalatha%3BMattison%2C+Donald+R%3BKollins%2C+Scott+H&rft.aulast=Witt&rft.aufirst=Kristine&rft.date=2008-12-01&rft.volume=47&rft.issue=12&rft.spage=1375&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+and+Adolescent+Psychiatry&rft.issn=1527-5418&rft_id=info:doi/10.1097%2FCHI.0b013e3181893620 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2008-12-03 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00341029; ClinicalTrials.gov N1 - SuppNotes - Cited By: Arch Pediatr Adolesc Med. 1999 Dec;153(12):1257-63 [10591302] Cancer Lett. 2008 Feb 18;260(1-2):216-8 [18055105] JAMA. 2000 Feb 23;283(8):1025-30 [10697062] Ann Clin Psychiatry. 2000 Mar;12(1):55-62 [10798827] Pediatrics. 2000 May;105(5):1158-70 [10836893] Pediatrics. 2000 Sep;106(3):533-9 [10969099] Mutat Res. 2003 May 9;537(1):67-79 [12742508] Biol Psychiatry. 2003 Dec 15;54(12):1307-9 [14675792] Cytogenet Genome Res. 2004;104(1-4):376-82 [15162068] J Learn Disabil. 2000 Jul-Aug;33(4):314; author reply 314-6 [15493092] Environ Mutagen. 1986;8 Suppl 7:1-119 [3516675] Environ Mol Mutagen. 1987;10 Suppl 10:1-175 [3319609] Mutat Res. 1989 Jun;212(2):149-54 [2733711] Cancer Res. 1989 Oct 15;49(20):5736-47 [2571410] J Am Acad Child Adolesc Psychiatry. 1997 Sep;36(9):1311-7 [9291734] J Am Acad Child Adolesc Psychiatry. 1997 Oct;36(10 Suppl):85S-121S [9334567] J Learn Disabil. 1998 Nov-Dec;31(6):533-44 [9813951] J Am Acad Child Adolesc Psychiatry. 1999 May;38(5):503-12 [10230181] Environ Health Perspect. 2005 Sep;113(9):1226-9 [16140632] Cancer Lett. 2005 Dec 18;230(2):292-4 [16019134] Cancer Lett. 2005 Dec 18;230(2):284-91 [16297714] Cancer Lett. 2006 Jan 8;231(1):146-8 [16290920] N Engl J Med. 2006 Apr 6;354(14):1445-8 [16549404] Mutat Res. 2006 Sep 5;607(2):153-9 [16829163] J Am Acad Child Adolesc Psychiatry. 2006 Oct;45(10):1147-50 [16840880] Biol Psychiatry. 2007 Mar 1;61(5):706-12 [16899230] Carcinogenesis. 2007 Mar;28(3):625-31 [16973674] Environ Mol Mutagen. 2007 Apr-May;48(3-4):322-9 [17358032] J Atten Disord. 2007 May;10(4):335-42 [17449832] Environ Health Perspect. 2007 Jun;115(6):936-40 [17589603] Expert Opin Pharmacother. 2007 Sep;8(13):2127-34 [17714065] J Manag Care Pharm. 2007 Sep;13(7):561-9 [17874862] Pharmacoepidemiol Drug Saf. 2007 Dec;16(12):1268-72 [18041106] J Am Acad Child Adolesc Psychiatry. 2000 Jan;39(1):28-38 [10638065] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/CHI.0b013e3181893620 ER - TY - JOUR T1 - Kinematics and kinetics of gait on stilts: identification of risk factors associated with construction stilt use. AN - 69828234; 18608480 AB - This study investigated kinematics and kinetic strategies and identified risk factors associated with gait on stilts. A six-camera motion-analysis system and two force platforms were used to test 20 construction workers for straight walking or turning, with or without carrying tools while wearing safety shoes or stilts at different heights. The results indicated that gait on stilts is characterised by increases in stride length, step width and the percentage of double support period, decreases in cadence, minimum foot clearance and a weaker heel-strike and push-off. Stilts place greater joint loadings on lower extremities to compensate for the added weight and limitation in joint mobility. Smaller foot clearances found for gait on stilts constitute an increased risk for tripping over obstacles. Workers may need to avoid prolonged use of stilts to alleviate stresses on the joints. This study was conducted to determine to what extent stilts alter the gait strategies and to explain the compensatory movements. Prior to this study, there has been little substantive research to evaluate the stresses and potential injuries associated with stilts. JF - Ergonomics AU - Chiou, Sharon S AU - Pan, Christopher S AU - Bhattacharya, Amit AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. schiou@cdc.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1814 EP - 1829 VL - 51 IS - 12 SN - 0014-0139, 0014-0139 KW - Index Medicus KW - Space life sciences KW - Occupational Exposure KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Equipment Design KW - Postural Balance -- physiology KW - Biomechanical Phenomena KW - Gait -- physiology KW - Facility Design and Construction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69828234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Kinematics+and+kinetics+of+gait+on+stilts%3A+identification+of+risk+factors+associated+with+construction+stilt+use.&rft.au=Chiou%2C+Sharon+S%3BPan%2C+Christopher+S%3BBhattacharya%2C+Amit&rft.aulast=Chiou&rft.aufirst=Sharon&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=1814&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130801961885 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/00140130801961885 ER - TY - JOUR T1 - Wearing an N95 respirator concurrently with a powered air-purifying respirator: effect on protection factor. AN - 69825980; 19025703 AB - To determine if using an N95 filtering face-piece respirator concurrently with a loose-fitting powered air-purifying respirator (PAPR) offers additional protection to the wearer. We used a breathing mannequin programmed to deliver minute volumes of 25 L/min and 40 L/min. We measured the baseline protection factor of the PAPR with its motor operational and then deactivated (to simulate mechanical or battery failure). We tested 3 replicates of 3 different N95 models. We glued each N95 to the breathing mannequin and obtained a minimum protection factor of 100 at 25 L/min. We then placed the PAPR on the mannequin and took protection factor measurements with the N95-plus-PAPR combination, at 25 L/min and 40 L/min, with the PAPR operational and then deactivated. The N95 significantly increased the PAPR's protection factor, even with the PAPR deactivated. The effect was multiplicative, not merely additive. An N95 decreases the concentration of airborne particles inspired by the wearer of a PAPR. JF - Respiratory care AU - Roberge, Marc R AU - Vojtko, Mark R AU - Roberge, Raymond J AU - Vojtko, Richard J AU - Landsittel, Douglas P AD - National Personal Protective Technology Laboratory of National Institute for Occupational Safety and Health of Centers for Disease Control and Prevention, PO Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA. dtn0@cdc.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1685 EP - 1690 VL - 53 IS - 12 SN - 0020-1324, 0020-1324 KW - Index Medicus KW - Equipment Design KW - Equipment Failure Analysis KW - Humans KW - Adult KW - Manikins KW - Models, Biological KW - Respiratory Protective Devices KW - Inhalation Exposure -- prevention & control KW - Air Microbiology KW - Disease Transmission, Infectious -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69825980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Respiratory+care&rft.atitle=Wearing+an+N95+respirator+concurrently+with+a+powered+air-purifying+respirator%3A+effect+on+protection+factor.&rft.au=Roberge%2C+Marc+R%3BVojtko%2C+Mark+R%3BRoberge%2C+Raymond+J%3BVojtko%2C+Richard+J%3BLandsittel%2C+Douglas+P&rft.aulast=Roberge&rft.aufirst=Marc&rft.date=2008-12-01&rft.volume=53&rft.issue=12&rft.spage=1685&rft.isbn=&rft.btitle=&rft.title=Respiratory+care&rft.issn=00201324&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Respir Care. 2008 Dec;53(12):1660-4 [19025698] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute pesticide poisoning among agricultural workers in the United States, 1998-2005. AN - 69824786; 18666136 AB - Approximately 75% of pesticide usage in the United States occurs in agriculture. As such, agricultural workers are at greater risk of pesticide exposure than non-agricultural workers. However, the magnitude, characteristics and trend of acute pesticide poisoning among agricultural workers are unknown. We identified acute pesticide poisoning cases in agricultural workers between the ages of 15 and 64 years that occurred from 1998 to 2005. The California Department of Pesticide Regulation and the SENSOR-Pesticides program provided the cases. Acute occupational pesticide poisoning incidence rates (IR) for those employed in agriculture were calculated, as were incidence rate ratios (IRR) among agricultural workers relative to non-agricultural workers. Of the 3,271 cases included in the analysis, 2,334 (71%) were employed as farmworkers. The remaining cases were employed as processing/packing plant workers (12%), farmers (3%), and other miscellaneous agricultural workers (19%). The majority of cases had low severity illness (N = 2,848, 87%), while 402 (12%) were of medium severity and 20 (0.6%) were of high severity. One case was fatal. Rates of illness among various agricultural worker categories were highly variable but all, except farmers, showed risk for agricultural workers greater than risk for non-agricultural workers by an order of magnitude or more. Also, the rate among female agricultural workers was almost twofold higher compared to males. The findings from this study suggest that acute pesticide poisoning in the agricultural industry continues to be an important problem. These findings reinforce the need for heightened efforts to better protect farmworkers from pesticide exposure. Copyright 2008 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Calvert, Geoffrey M AU - Karnik, Jennifer AU - Mehler, Louise AU - Beckman, John AU - Morrissey, Barbara AU - Sievert, Jennifer AU - Barrett, Rosanna AU - Lackovic, Michelle AU - Mabee, Laura AU - Schwartz, Abby AU - Mitchell, Yvette AU - Moraga-McHaley, Stephanie AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA. jac6@cdc.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 883 EP - 898 VL - 51 IS - 12 KW - Pesticides KW - 0 KW - Index Medicus KW - Severity of Illness Index KW - Acute Disease KW - Young Adult KW - Humans KW - Retrospective Studies KW - Risk Assessment KW - Age Distribution KW - Survival Rate KW - Pest Control KW - Adult KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Male KW - Occupational Exposure KW - Agricultural Workers' Diseases -- epidemiology KW - Pesticides -- poisoning KW - Agricultural Workers' Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69824786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Acute+pesticide+poisoning+among+agricultural+workers+in+the+United+States%2C+1998-2005.&rft.au=Calvert%2C+Geoffrey+M%3BKarnik%2C+Jennifer%3BMehler%2C+Louise%3BBeckman%2C+John%3BMorrissey%2C+Barbara%3BSievert%2C+Jennifer%3BBarrett%2C+Rosanna%3BLackovic%2C+Michelle%3BMabee%2C+Laura%3BSchwartz%2C+Abby%3BMitchell%2C+Yvette%3BMoraga-McHaley%2C+Stephanie&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.20623 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20623 ER - TY - JOUR T1 - Proportionate mortality study of the United Association of Journeymen and Apprentices of the Plumbing and Pipe Fitting Industry. AN - 69819087; 18942099 AB - This study examined causes of deaths among unionized plumbers, pipefitters and allied trades. Deaths of union members from the years 1971, 1979, 1987, and 1995 were selected as a representative sample from a computer file provided by the union. These years provided 15,411 deaths for proportionate mortality ratio (PMR) analysis. PMRs for lung cancer and asbestosis were significantly elevated compared to U.S. white males. PMRs for chronic disease of the endocardium and cardiomyopathy were also elevated. Elevations were not observed in other a priori causes: laryngeal cancer, lymphatic cancer, and neurological disorders. PMRs for transportation accidents for pipe/steam-fitters were elevated in 1971 and 1979, but not in 1987 or 1995. Despite the limitations of a PMR analysis, study results indicate mortality related to asbestos exposure is, and will continue to be, an area of concern for members of the union. Copyright 2008 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Lehman, Everett J AU - Hein, Misty J AU - Estill, Cheryl F AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. elehman@cdc.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 950 EP - 963 VL - 51 IS - 12 KW - Index Medicus KW - Causality KW - Young Adult KW - Occupational Health KW - Humans KW - Retrospective Studies KW - Hematologic Neoplasms -- mortality KW - Cardiovascular Diseases -- mortality KW - Asbestosis -- mortality KW - Labor Unions KW - Adult KW - Databases, Factual KW - Lung Neoplasms -- mortality KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Survival Analysis KW - Occupational Exposure KW - Metallurgy KW - Cause of Death KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69819087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Proportionate+mortality+study+of+the+United+Association+of+Journeymen+and+Apprentices+of+the+Plumbing+and+Pipe+Fitting+Industry.&rft.au=Lehman%2C+Everett+J%3BHein%2C+Misty+J%3BEstill%2C+Cheryl+F&rft.aulast=Lehman&rft.aufirst=Everett&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=950&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.20640 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20640 ER - TY - JOUR T1 - Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide. AN - 69778523; 18812491 AB - A variety of peptide ligands are known to inhibit the function of neuronal nicotinic acetylcholine receptors (nAChRs), including small toxins and brain-derived peptides such as beta-amyloid(1-42) and synthetic apolipoproteinE peptides. The myristoylated alanine-rich C kinase substrate (MARCKS) protein is a major substrate of protein kinase C and is highly expressed in the developing and adult brain. The ability of a 25-amino acid synthetic MARCKS peptide, derived from the effector domain (ED), to modulate nAChR activity was tested. To determine the effects of the MARCKS ED peptide on nAChR function, receptors were expressed in Xenopus laevis oocytes, and two-electrode voltage-clamp experiments were performed. The MARCKS ED peptide completely inhibited acetylcholine (ACh)-evoked responses from alpha7 nAChRs in a dose-dependent manner, yielding an IC(50) value of 16 nM. Inhibition of ACh-induced responses was both activity- and voltage-independent. The MARCKS ED peptide was unable to block alpha-bungarotoxin binding. A MARCKS ED peptide in which four serine residues were replaced with aspartate residues was unable to inhibit alpha7 nAChR-mediated currents. The MARCKS ED peptide inhibited ACh-induced alpha4beta2 and alpha2beta2 responses, although with decreased potency. The effects of the MARCKS ED peptide on native nAChRs were tested using acutely isolated rat hippocampal slices. In hippocampal interneurons, the MARCKS ED peptide was able to block native alpha7 nAChRs in a dose-dependent manner. The MARCKS ED peptide represents a novel antagonist of neuronal nAChRs that has considerable utility as a research tool. JF - The Journal of pharmacology and experimental therapeutics AU - Gay, Elaine A AU - Klein, Rebecca C AU - Melton, Mark A AU - Blackshear, Perry J AU - Yakel, Jerrel L AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 884 EP - 890 VL - 327 IS - 3 KW - Chrna7 protein, human KW - 0 KW - Chrna7 protein, rat KW - Intracellular Signaling Peptides and Proteins KW - Membrane Proteins KW - Nicotinic Antagonists KW - Receptors, Nicotinic KW - Recombinant Proteins KW - alpha7 Nicotinic Acetylcholine Receptor KW - myristoylated alanine-rich C kinase substrate KW - 125267-21-2 KW - Index Medicus KW - Rats KW - Xenopus laevis KW - Animals KW - Dose-Response Relationship, Drug KW - Oocytes KW - Inhibitory Concentration 50 KW - Electrophysiology KW - Mutation, Missense KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Receptors, Nicotinic -- drug effects KW - Membrane Proteins -- genetics KW - Intracellular Signaling Peptides and Proteins -- physiology KW - Membrane Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69778523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Inhibition+of+native+and+recombinant+nicotinic+acetylcholine+receptors+by+the+myristoylated+alanine-rich+C+kinase+substrate+peptide.&rft.au=Gay%2C+Elaine+A%3BKlein%2C+Rebecca+C%3BMelton%2C+Mark+A%3BBlackshear%2C+Perry+J%3BYakel%2C+Jerrel+L&rft.aulast=Gay&rft.aufirst=Elaine&rft.date=2008-12-01&rft.volume=327&rft.issue=3&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.144758 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-05 N1 - Date created - 2008-11-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2006 Sep;318(3):956-65 [16740622] Hippocampus. 2006;16(5):495-503 [16572394] J Pharmacol Exp Ther. 2001 Aug;298(2):395-402 [11454899] Mol Pharmacol. 2002 Jan;61(1):43-54 [11752205] Biochem J. 2002 Feb 15;362(Pt 1):1-12 [11829734] J Physiol. 2000 Sep 15;527 Pt 3:515-28 [10990538] J Neurosci. 2001 Jan 1;21(1):RC120 [11150356] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4734-9 [11274373] Eur J Neurosci. 2001 May;13(10):1849-60 [11403678] J Biol Chem. 2002 Jul 12;277(28):25056-61 [11983690] J Physiol. 2003 Feb 15;547(Pt 1):147-57 [12562926] Nat Struct Biol. 2003 Mar;10(3):226-31 [12577052] Br J Pharmacol. 2003 Jul;139(6):1061-73 [12871824] J Neurosci. 2003 Jul 30;23(17):6740-7 [12890766] J Neurosci. 2003 Oct 8;23(27):9024-31 [14534236] Biochem Cell Biol. 2004 Feb;82(1):191-200 [15052337] J Neurochem. 2004 Jul;90(2):325-31 [15228589] Neuroscience. 2004;127(3):563-7 [15283956] J Biol Chem. 2004 Sep 3;279(36):37842-51 [15234980] J Physiol. 1988 Jan;395:131-59 [2457675] J Biol Chem. 1989 Dec 25;264(36):21818-23 [2557340] J Neurosci. 1990 May;10(5):1683-98 [2332803] J Biol Chem. 1991 Aug 5;266(22):14390-8 [1650359] Cell. 1992 Nov 27;71(5):713-6 [1423627] J Physiol. 1992 Aug;454:155-82 [1282155] J Biol Chem. 1993 Jan 25;268(3):1501-4 [8420923] Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):944-8 [7862670] J Biol Chem. 1996 Jan 5;271(1):553-62 [8550618] J Biol Chem. 1997 Sep 19;272(38):23833-42 [9295331] Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14517-22 [9826732] Exp Neurol. 2005 Mar;192(1):109-16 [15698624] Neurosci Lett. 2005 Jun 24;381(3):305-8 [15896489] Hippocampus. 2005;15(5):675-83 [15889447] J Mol Neurosci. 2005;27(1):13-21 [16055943] Neuron. 2005 Oct 6;48(1):77-90 [16202710] J Pharmacol Exp Ther. 2006 Feb;316(2):835-42 [16249370] Biochem Pharmacol. 2007 Oct 15;74(8):1092-101 [17662959] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.144758 ER - TY - JOUR T1 - Racial/ethnic and gender differences in individual workplace injury risk trajectories: 1988-1998. AN - 69775586; 18235072 AB - I examined workplace injury risk over time and across racial/ethnic and gender groups to observe patterns of change and to understand how occupational characteristics and job mobility influence these changes. I used hierarchical generalized linear models to estimate individual workplace injury and illness risk over time ("trajectories") for a cohort of American workers who participated in the National Longitudinal Survey of Youth (1988-1998). Significant temporal variation in injury risk was observed across racial/ethnic and gender groups. At baseline, White men had a high risk of injury relative to the other groups and experienced the greatest decline over time. Latino men demonstrated a pattern of lower injury risk across time compared with White men. Among both Latinos and non-Latino Whites, women had lower odds of injury than did men. Non-Latino Black women's injury risk was similar to Black men's and greater than that for both Latino and non-Latino White women. Occupational characteristics and job mobility partly explained these differences. Disparities between racial/ethnic and gender groups were dynamic and changed over time. Workplace injury risk was associated with job dimensions such as work schedule, union representation, health insurance, job hours, occupational racial segregation, and occupational environmental hazards. JF - American journal of public health AU - Berdahl, Terceira A AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. terceira.berdahl@ahrq.hhs.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2258 EP - 2263 VL - 98 IS - 12 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Linear Models KW - Minority Groups -- statistics & numerical data KW - Longitudinal Studies KW - Vulnerable Populations -- statistics & numerical data KW - Population Surveillance KW - Risk Assessment KW - Risk Factors KW - Health Surveys KW - Surveys and Questionnaires KW - Health Status Disparities KW - Occupations -- statistics & numerical data KW - United States -- epidemiology KW - Time Factors KW - Sex Distribution KW - Female KW - Male KW - Hispanic Americans -- statistics & numerical data KW - Accidents, Occupational -- trends KW - Wounds and Injuries -- etiology KW - African Americans -- statistics & numerical data KW - European Continental Ancestry Group -- statistics & numerical data KW - Wounds and Injuries -- ethnology KW - Workplace -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69775586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Racial%2Fethnic+and+gender+differences+in+individual+workplace+injury+risk+trajectories%3A+1988-1998.&rft.au=Berdahl%2C+Terceira+A&rft.aulast=Berdahl&rft.aufirst=Terceira&rft.date=2008-12-01&rft.volume=98&rft.issue=12&rft.spage=2258&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=1541-0048&rft_id=info:doi/10.2105%2FAJPH.2006.103135 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-02 N1 - Date created - 2008-11-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Occup Environ Med. 2000 Oct;42(10):1035-40 [11039167] Am J Public Health. 2003 Feb;93(2):221-6 [12554573] Soc Sci Med. 2003 Dec;57(11):2173-82 [14512247] Ergonomics. 2004 Apr 15;47(5):495-526 [15204301] Milbank Mem Fund Q Health Soc. 1984 Fall;62(4):567-90 [6569359] J Occup Med. 1993 Sep;35(9):916-21 [8229344] Am J Public Health. 2007 Jun;97(6):1096-101 [17463379] Am J Public Health. 1998 Jan;88(1):40-4 [9584031] Am J Public Health. 2005 Mar;95(3):483-8 [15727981] Am J Public Health. 2005 Jul;95(7):1213-9 [15983273] Am J Public Health. 2005 Jul;95(7):1226-32 [15983275] Am J Public Health. 2007 May;97(5):919-25 [17395846] Am J Public Health. 1994 Nov;84(11):1846-8 [7977933] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2105/AJPH.2006.103135 ER - TY - JOUR T1 - Differentiating non-asbestiform amphibole and amphibole asbestos by size characteristics. AN - 69617004; 18828048 AB - Mining or processing asbestos minerals can liberate isolated fibers or fiber bundles regulated as airborne asbestos fibers. Coarsely crystalline amphibole minerals are more common than asbestos in many geologic environments, and disturbance can result in the release of prismatic or acicular single crystals or cleavage fragments resembling asbestos fibers or fiber bundles but that are not currently regulated as asbestos. Bulk samples of six coarsely crystalline amphiboles and their five asbestos analogs were processed to maximize the number of particles meeting the criterion for counting under the current U.S. National Institute for Occupational Safety and Health Method 7400 "A" counting rules (> 5 microm long with an aspect ratio >or= 3:1) and also within the respirable width range, i.e. < 3 microm width. The length distributions of the particles produced showed substantial overlap between cleavage fragments and asbestos fibers. Available data sets generally confirmed the relevance of the size distributions of particles generated from reference materials to airborne particles. The length criterion in the current ASTM International standard D7200-06 causes a large proportion (e.g., 40% grunerite and 39% tremolite) of the non-asbestiform particles to be considered potential asbestos. An alternative procedure may be to use a distinction based on width alone as some, but not the majority of, cleavage fragments were thinner than 1 microm (e.g., 9% of actinolite and 20% of grunerite particles), and not many amphibole asbestos particles were wider (e.g., 5% of crocidolite and 18% of amosite particles). This proposal would need further testing. This research should not be considered as addressing any controversy with regard to the toxicity of non-asbestiform amphibole particles of similar dimensions to asbestos particles. JF - Journal of occupational and environmental hygiene AU - Harper, Martin AU - Lee, Eun Gyung AU - Doorn, Stacy S AU - Hammond, Okisha AD - Health Effects Laboratory Division, Exposure Assessment Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. zzg7@cdc.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 761 EP - 770 VL - 5 IS - 12 KW - Air Pollutants, Occupational KW - 0 KW - Asbestos, Amphibole KW - Particulate Matter KW - Index Medicus KW - United States KW - Particle Size KW - United States Occupational Safety and Health Administration KW - Guidelines as Topic KW - Environmental Monitoring -- methods KW - Air Pollutants, Occupational -- analysis KW - Asbestos, Amphibole -- chemistry KW - Particulate Matter -- chemistry KW - Particulate Matter -- analysis KW - Air Pollutants, Occupational -- chemistry KW - Occupational Exposure -- analysis KW - Asbestos, Amphibole -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69617004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Differentiating+non-asbestiform+amphibole+and+amphibole+asbestos+by+size+characteristics.&rft.au=Harper%2C+Martin%3BLee%2C+Eun+Gyung%3BDoorn%2C+Stacy+S%3BHammond%2C+Okisha&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2008-12-01&rft.volume=5&rft.issue=12&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620802462290 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620802462290 ER - TY - JOUR T1 - Recurring outbreaks of Salmonella typhimurium phage type 135 associated with the consumption of products containing raw egg in Tasmania. AN - 66712873; 19374277 AB - Large egg-associated outbreaks of Salmonella Typhimurium 135 (STm135) that were associated with inadequate food safety practices but also linked to a common poultry farm occurred in Tasmania in 2005. A series of public health interventions were implemented to prevent further occurrences but 2 more egg-associated outbreaks in Tasmania in March 2007 and January 2008 led to a further 66 cases of STm135. This report describes these outbreaks and their links to the common source associated with the outbreaks in 2005. JF - Communicable diseases intelligence quarterly report AU - Stephens, Nicola AU - Coleman, David AU - Shaw, Kathleen AD - Communicable Diseases Prevention Unit, Department of Health and Human Services, Hobart, Tasmania. nicola.stephens@dhhs.tas.gov.au Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 466 EP - 468 VL - 32 IS - 4 SN - 1447-4514, 1447-4514 KW - Index Medicus KW - Tasmania -- epidemiology KW - Animals KW - Food Microbiology KW - Humans KW - Cooking KW - Food Contamination KW - Salmonella Food Poisoning -- epidemiology KW - Salmonella Food Poisoning -- microbiology KW - Time Factors KW - Eggs -- microbiology KW - Salmonella Infections -- microbiology KW - Salmonella Infections -- epidemiology KW - Disease Outbreaks KW - Salmonella typhimurium -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66712873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Communicable+diseases+intelligence+quarterly+report&rft.atitle=Recurring+outbreaks+of+Salmonella+typhimurium+phage+type+135+associated+with+the+consumption+of+products+containing+raw+egg+in+Tasmania.&rft.au=Stephens%2C+Nicola%3BColeman%2C+David%3BShaw%2C+Kathleen&rft.aulast=Stephens&rft.aufirst=Nicola&rft.date=2008-12-01&rft.volume=32&rft.issue=4&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Communicable+diseases+intelligence+quarterly+report&rft.issn=14474514&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-14 N1 - Date created - 2009-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rapid detection of Salmonella in foods using real-time PCR. AN - 66694972; 19256088 AB - Conventional methods for detection of Salmonella serovars in foods are generally time-consuming and labor intensive. A real-time PCR method has been developed with custom designed primers and a TaqMan probe to detect the presence of a 262-bp fragment of the Salmonella-specific invA gene. The method has been tested with a total of 384 field-isolated Salmonella serovars and non-Salmonella stock strains, as well as 420 U.S. Food and Drug Administration food samples, comprising a variety of food matrices. The method was highly specific in detecting Salmonella in spiked chili powder and shrimp samples, with a sensitivity of 0.04 CFU/g. In addition, the method is faster, more accurate, and less costly than the traditional U.S. Food and Drug Administration's Bacteriological Analytical Manual cell-culturing and the AOAC International-approved VIDAS methods to detect Salmonella in foods. JF - Journal of food protection AU - Cheng, Chorng-Ming AU - Lin, Wen AU - Van, Khanh Thien AU - Phan, Lieuchi AU - Tran, Nelly N AU - Farmer, Doris AD - U.S. Food and Drug Administration, Pacific Regional Laboratory Southwest, Irvine, California 92612, USA. chorng-ming.cheng@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2436 EP - 2441 VL - 71 IS - 12 SN - 0362-028X, 0362-028X KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - invA protein, Bacteria KW - 147652-43-5 KW - Index Medicus KW - Sensitivity and Specificity KW - Colony Count, Microbial -- methods KW - Food Microbiology KW - DNA, Bacterial -- chemistry KW - Humans KW - DNA, Bacterial -- genetics KW - Serotyping KW - Time Factors KW - Species Specificity KW - Gene Amplification KW - Salmonella enterica -- isolation & purification KW - Polymerase Chain Reaction -- methods KW - Food Contamination -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66694972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Rapid+detection+of+Salmonella+in+foods+using+real-time+PCR.&rft.au=Cheng%2C+Chorng-Ming%3BLin%2C+Wen%3BVan%2C+Khanh+Thien%3BPhan%2C+Lieuchi%3BTran%2C+Nelly+N%3BFarmer%2C+Doris&rft.aulast=Cheng&rft.aufirst=Chorng-Ming&rft.date=2008-12-01&rft.volume=71&rft.issue=12&rft.spage=2436&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-30 N1 - Date created - 2009-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systematic method for determining an ideal housekeeping gene for real-time PCR analysis. AN - 66671958; 19183798 AB - To standardize the amount of biological material between samples (e.g., number of cells or amount of tissue) for quantitative real-time reverse transcriptase PCR (qRT-PCR), the cycle of the target gene at which expression is detected (the cycle threshold, or Ct) is divided by the Ct of a gene either thought to be unaffected by experimental conditions or similarly expressed among donors. Genes that maintain cellular structure or homeostasis, referred to as housekeeping genes, or 18S ribosomal RNA are often used for this purpose. Although unstable or inconsistent housekeeping gene expression will misrepresent experimental effects on target gene expression, housekeeping genes are often chosen arbitrarily rather than systematically. We designed a simple and systematic approach towards selection of housekeeping genes based on Ct variance (as reflected by the standard deviation) and normality of distribution. We validated this approach by comparing stability and consistency of expression of 11 housekeeping genes across different types of cells, experimental treatments, and human donors. Finally, we demonstrated the consequences of inconsistent housekeeping gene expression on the calculation of target gene expression, and conclude that validation of stability of housekeeping gene expression by considering both distribution normality and standard deviation is straightforward and critical for proper experimental design. JF - Journal of biomolecular techniques : JBT AU - Mane, Viraj P AU - Heuer, Melissa A AU - Hillyer, Philippa AU - Navarro, Maria B AU - Rabin, Ronald L AD - Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892-4555, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 342 EP - 347 VL - 19 IS - 5 KW - Lipopolysaccharides KW - 0 KW - Ionomycin KW - 56092-81-0 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - housekeeping genes KW - cycle threshold KW - quantitative real time reverse transcriptase PCR (RT-CR) KW - CD4+ T cells KW - CD4-Positive T-Lymphocytes -- metabolism KW - Lipopolysaccharides -- pharmacology KW - Humans KW - Monocytes -- metabolism KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Monocytes -- drug effects KW - Ionomycin -- pharmacology KW - CD4-Positive T-Lymphocytes -- drug effects KW - Cell Line KW - Biotechnology KW - Gene Expression -- drug effects KW - Reverse Transcriptase Polymerase Chain Reaction -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66671958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomolecular+techniques+%3A+JBT&rft.atitle=Systematic+method+for+determining+an+ideal+housekeeping+gene+for+real-time+PCR+analysis.&rft.au=Mane%2C+Viraj+P%3BHeuer%2C+Melissa+A%3BHillyer%2C+Philippa%3BNavarro%2C+Maria+B%3BRabin%2C+Ronald+L&rft.aulast=Mane&rft.aufirst=Viraj&rft.date=2008-12-01&rft.volume=19&rft.issue=5&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomolecular+techniques+%3A+JBT&rft.issn=1943-4731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-02 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biotechnol Lett. 2004 Mar;26(6):509-15 [15127793] J Immunol. 1993 Aug 15;151(4):1938-49 [8102154] Blood. 1995 Aug 15;86(4):1408-19 [7632949] Biochem Biophys Res Commun. 1995 Dec 5;217(1):363-9 [8526935] Int Immunol. 2006 Mar;18(3):485-93 [16481346] Genome Biol. 2002 Jun 18;3(7):RESEARCH0034 [12184808] Methods. 2001 Dec;25(4):402-8 [11846609] Physiol Genomics. 2001 Dec 21;7(2):97-104 [11773596] Anal Biochem. 2002 Oct 15;309(2):293-300 [12413463] Biochem Biophys Res Commun. 1999 Jun 16;259(3):523-6 [10364451] Oncol Rep. 1998 Mar-Apr;5(2):469-71 [9468581] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The concept of sustainability and the use of outcome indicators. A case study to continue a successful health counselling intervention AN - 57280425; 200906445 AB - Background. To ensure the continuation of a successful pilot programme, the change process and the concept of sustainability need to be elaborated. So far, there are different theories on organizational change and sustainability but its practical application stay far behind. Objectives. To test the practical application of a theory-based concept of sustainability and to assess the role of the change agent. A health counselling programme for high-risk cardiovascular patients, called Heartbeat 2, was used as a case study. Methods. Outcome indicators were assessed based on the questions: Why should health counselling be sustained? How should this be done and by whom? How much needs to occur and by when? Data were derived from registrations, reports and focus group interviews. Results. The results indicate a need for a linkage system in the final stages of change so that the programme is maintained. Limitations of the external change agent are described. The outcome indicators appeared to be an adequate operationalization to monitor sustainability. The change process leading up to sustainability appeared to be highly complex due to unpredictable and unforeseen external factors. Conclusions. Our concept of sustainability appeared to be an adequate tool for the change agent to assess the extent of sustainability. An external change agent has limited influence on the management's decision-making processes during the sustainability stage. As long as the context is changing, definite choices to sustain the innovative service of health counselling in hospitals will not be made, which inherently means an ongoing change process to sustainability. Adapted from the source document. JF - Family Practice AU - Jansen, Maria AU - Harting, Janneke AU - Ebben, Nicole AU - Kroon, Bram AU - Stappers, Jan AU - Van Engelshoven, Esther AU - de Vries, Nanne AD - Public Health Service South Limburg Management, PO Box 2022, Geleen 6160, The Netherlands maria.jansen@ggdzl.nl Y1 - 2008/12// PY - 2008 DA - December 2008 SP - i32 EP - i37 PB - Oxford University Press VL - 25 IS - Supplement 1 SN - 0263-2136, 0263-2136 KW - Capacity planning, change agent, institutionalization, organizational development, sustainability KW - Change agents KW - Counselling KW - Organizational change KW - Sustainability KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57280425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+Practice&rft.atitle=The+concept+of+sustainability+and+the+use+of+outcome+indicators.+A+case+study+to+continue+a+successful+health+counselling+intervention&rft.au=Jansen%2C+Maria%3BHarting%2C+Janneke%3BEbben%2C+Nicole%3BKroon%2C+Bram%3BStappers%2C+Jan%3BVan+Engelshoven%2C+Esther%3Bde+Vries%2C+Nanne&rft.aulast=Jansen&rft.aufirst=Maria&rft.date=2008-12-01&rft.volume=25&rft.issue=Supplement+1&rft.spage=i32&rft.isbn=&rft.btitle=&rft.title=Family+Practice&rft.issn=02632136&rft_id=info:doi/10.1093%2Ffampra%2Fcmn066 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Sustainability; Change agents; Counselling; Hospitals; Organizational change DO - http://dx.doi.org/10.1093/fampra/cmn066 ER - TY - JOUR T1 - A few remarks on 'A capture-recapture approach for screening using two diagnostic tests with availability of disease status for the test positives only' by Böhning and Patilea AN - 37103475; 3843275 JF - Journal of the American Statistical Association AU - Chu, Haitao AU - Nie, Lei AD - University of North Carolina ; US Office of Biostatistics, Food and Drug Administration Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1518 EP - 1519 VL - 103 IS - 484 SN - 0162-1459, 0162-1459 KW - Sociology KW - Statistics KW - Medical research KW - Diseases KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37103475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=A+few+remarks+on+%27A+capture-recapture+approach+for+screening+using+two+diagnostic+tests+with+availability+of+disease+status+for+the+test+positives+only%27+by+B%C3%B6hning+and+Patilea&rft.au=Chu%2C+Haitao%3BNie%2C+Lei&rft.aulast=Chu&rft.aufirst=Haitao&rft.date=2008-12-01&rft.volume=103&rft.issue=484&rft.spage=1518&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F01621450800000094%3F%3F LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12233; 3617 6220; 7886 10902 DO - http://dx.doi.org/10.1198/01621450800000094?? ER - TY - JOUR T1 - An Unsupervised Neural Network to Predict the Level of Heat Stress AN - 217133509; 19031102 AB - Heat stress is known to induce high mortality rate due to multi-system illness, which demands urgent attention to reduce the fatality rate in such patients. Further, for the diagnosis and supportive therapy, one needs to define the severity of heat stress that can be distinguished as mild, intermediate and severe. The objective of this work is to develop an automated unsupervised artificial system to analyze the clinical outcomes of different levels of heat related illnesses. The Kohonen neural network program written in C++, which has seven normalized values of different clinical symptoms between 0-1 fed to the input layer of the network with 50 Kohonen output neurons, has been presented. The optimized initializing parameters such as neighborhood size and learning rate was set to 50 and 0.7, respectively, to simulate the network for 10 million iterations. The network was found smartly distinguishing all 51 patterns to three different states of heat illnesses. With the advent of these findings, it can be concluded that the Kohonen neural network can be used for automated classification of the severity of heat stress and other related psycho-patho-physiological disorders. However, to replace the expert clinicians with such type of smart diagnostic tool, extensive work is required to optimize the system with variety of known and hidden clinical and pathological parameters. JF - Journal of Clinical Monitoring and Computing AU - Aggarwal, Yogender AU - Karan, Bhuwan Mohan AU - Das, Barda Nand AU - Sinha, Rakesh Kumar Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 425 EP - 30 CY - Dordrecht PB - Springer Science & Business Media VL - 22 IS - 6 SN - 13871307 KW - Medical Sciences--Computer Applications KW - Humans KW - Heat Stress Disorders -- diagnosis KW - Diagnosis, Computer-Assisted -- methods KW - Neural Networks (Computer) KW - Decision Support Systems, Clinical KW - Algorithms KW - Pattern Recognition, Automated -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/217133509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Monitoring+and+Computing&rft.atitle=An+Unsupervised+Neural+Network+to+Predict+the+Level+of+Heat+Stress&rft.au=Aggarwal%2C+Yogender%3BKaran%2C+Bhuwan+Mohan%3BDas%2C+Barda+Nand%3BSinha%2C+Rakesh+Kumar&rft.aulast=Aggarwal&rft.aufirst=Yogender&rft.date=2008-12-01&rft.volume=22&rft.issue=6&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Monitoring+and+Computing&rft.issn=13871307&rft_id=info:doi/10.1007%2Fs10877-008-9152-x LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2009 N1 - Last updated - 2014-08-30 N1 - CODEN - JCMCFG DO - http://dx.doi.org/10.1007/s10877-008-9152-x ER - TY - JOUR T1 - Overview of Recent Studies of Community-Acquired Pneumonia AN - 21433287; 12488324 AB - All recent studies of antibacterial drugs for the indication of community-acquired pneumonia submitted to the US Food and Drug Administration have been designed as noninferiority studies. We provide a summary of results of 7 recent clinical studies of oral antibacterial drugs for treatment of community-acquired pneumonia. In these 7 studies, the majority of patients enrolled had Pneumonia Patient Outcomes Research Team scores of I or II. The percentage of randomized subjects with pathogens identified at baseline ranged from 47% to 76%, and the percentage of subjects with Streptoccocus pneumoniae isolated at baseline ranged from 66% to 20%. The primary end point in these studies was clinical cure, assessed 7-21 days after completion of therapy. Clinical cure rates were >80% in the intent-to-treat populations and >90% in the per-protocol populations. We also briefly summarize the results from several recently submitted clinical studies of intravenously administered antibacterial drugs for treatment of community-acquired pneumonia, in which we found similar results. JF - Clinical Infectious Diseases AU - Higgins, K AU - Singer, M AU - Valappil, T AU - Nambiar, S AU - Lin, D AU - Cox, E AD - US Food and Drug Administration, Center for Drug Evaluation and Research, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA, karen.higgins@fda.hhs.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - S150 EP - S156 VL - 47 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Reviews KW - Pathogens KW - Pneumonia KW - A 01330:Food Microbiology KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21433287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Overview+of+Recent+Studies+of+Community-Acquired+Pneumonia&rft.au=Higgins%2C+K%3BSinger%2C+M%3BValappil%2C+T%3BNambiar%2C+S%3BLin%2C+D%3BCox%2C+E&rft.aulast=Higgins&rft.aufirst=K&rft.date=2008-12-01&rft.volume=47&rft.issue=&rft.spage=S150&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F591397 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Reviews; Pathogens; Pneumonia DO - http://dx.doi.org/10.1086/591397 ER - TY - RPRT T1 - Apprentice Electrician Electrocuted while Wiring an Elevator Disconnect Switch - Massachusetts AN - 20973691; 11069914 AB - On October 23, 2006, a 24-year-old male apprentice electrician was electrocuted by an energized 480-volt, three-phase circuit while permanently wiring a heavy duty disconnect switch for a new elevator. The supply side of the disconnect switch had three energized wires fed into it through the switch's top mechanical lugs. At the time of the incident, the victim had just finished disconnecting the three energized wires from the switch's top mechanical lugs and came in contact with an energized source, either a wire or the switch housing, and was electrocuted. A co-worker noticed a bright flash and, upon investigating the source of the flash, found the victim slumped on the ground of the elevator mechanical room. The co-worker yelled for help and started to attend to the victim. A second co-worker entered the elevator mechanical room and then placed a call for emergency medical services (EMS). Both co-workers administered cardiopulmonary resuscitation (CPR) until the arrival of EMS a few minutes later. The local police and fire departments were also notified and responded to the incident site. EMS transported the victim to a local hospital were the victim was pronounced dead. The Massachusetts FACE Program concluded that to prevent similar occurrences in the future, employers should: Ensure that electrical circuits and equipment are de-energized and that lockout/tagout procedures are implemented and enforced prior to beginning work; In addition, general contractors, when feasible, should: Ensure that elevators are permanently wired during installation. JF - Apprentice Electrician Electrocuted while Wiring an Elevator Disconnect Switch - Massachusetts. [np]. Dec 2008. AU - Anonymous Y1 - 2008/12// PY - 2008 DA - Dec 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Fires KW - USA, Massachusetts KW - police KW - Housing KW - emergency medical services KW - Hospitals KW - H 7000:Fire Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20973691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=A+Model+Observer+for+the+Assessment+of+Display+Temporal+Characteristics&rft.au=Liang%2C+Hongye%3BBadano%2C+Aldo&rft.aulast=Liang&rft.aufirst=Hongye&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Microarray-based assay for the detection of genetic variations of structural genes of West Nile virus AN - 20738743; 8869334 AB - Adaptation through fixation of spontaneous mutations in the viral genome is considered to be one of the important factors that enable recurrent West Nile virus (WNV) outbreaks in the U.S. Genetic variations can alter viral phenotype and virulence, and degrade the performance of diagnostic and screening assays, vaccines, and potential therapeutic agents. A microarray assay was developed and optimized for the simultaneous detection of any nucleotide mutations in the entire structural region of WNV in order to facilitate public health surveillance of genetic variation of WNV. The DNA microarray consists of 263 oligonucleotide probes overlapping at half of their lengths which have been immobilized on an amine-binding glass slide. The assay was validated using 23 WNV isolates from the 2002-2005 U.S. epidemics. Oligonucleotide-based WNV arrays detected unambiguously all mutations in the structural region of each one of the isolates identified previously by sequencing analysis, serving as a rapid and effective approach for the identification of mutations in the WNV genome. JF - Journal of Virological Methods AU - Grinev, A AU - Daniel, S AU - Laassri, M AU - Chumakov, K AU - Chizhikov, V AU - Rios, M AD - Division of Emerging and Transfusion Transmitted Diseases, Rockville, MD 20852, USA, Andriyan.Grinev@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 27 EP - 40 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 154 IS - 1-2 SN - 0166-0934, 0166-0934 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Genomes KW - Epidemics KW - Adaptations KW - DNA probes KW - Genetic diversity KW - DNA microarrays KW - Oligonucleotides KW - Nucleotides KW - Public health KW - Virulence KW - Vaccines KW - Mutation KW - West Nile virus KW - G 07880:Human Genetics KW - V 22300:Methods KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20738743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Microarray-based+assay+for+the+detection+of+genetic+variations+of+structural+genes+of+West+Nile+virus&rft.au=Grinev%2C+A%3BDaniel%2C+S%3BLaassri%2C+M%3BChumakov%2C+K%3BChizhikov%2C+V%3BRios%2C+M&rft.aulast=Grinev&rft.aufirst=A&rft.date=2008-12-01&rft.volume=154&rft.issue=1-2&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2008.09.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Virulence; Genomes; Adaptations; Epidemics; DNA probes; Genetic diversity; Vaccines; Oligonucleotides; DNA microarrays; Mutation; Nucleotides; Public health; West Nile virus DO - http://dx.doi.org/10.1016/j.jviromet.2008.09.015 ER - TY - JOUR T1 - Evaluation of a comprehensive slip, trip and fall prevention programme for hospital employees AN - 20694750; 10271014 AB - In 2007, the Bureau of Labor Statistics reported that the incidence rate of lost workday injuries from slips, trips and falls (STFs) on the same level in hospitals was 35.2 per 10,000 full-time equivalents (FTE), which was 75% greater than the average rate for all other private industries combined (20.2 per 10,000 FTEs). The objectives of this 10-year (1996-2005) longitudinal study were to: 1) describe occupational STF injury events in hospitals; 2) evaluate the effectiveness of a comprehensive programme for reducing STF incidents among hospital employees. The comprehensive prevention programme included analysis of injury records to identify common causes of STFs, on-site hazard assessments, changes to housekeeping procedures and products, introduction of STF preventive products and procedures, general awareness campaigns, programmes for external ice and snow removal, flooring changes and slip-resistant footwear for certain employee subgroups. The hospitals' total STF workers' compensation claims rate declined by 58% from the pre-intervention (1996-1999) rate of 1.66 claims per 100 FTE to the post-intervention (2003-2005) time period rate of 0.76 claims per 100 FTE (adjusted rate ratio = 0.42, 95% CI: 0.33-0.54). STFs due to liquid contamination (water, fluid, slippery, greasy and slick spots) were the most common cause (24%) of STF claims for the entire study period 1996-2005. Food services, transport/emergency medical service and housekeeping staff were at highest risk of a STF claim in the hospital environment. Nursing and office administrative staff generated the largest numbers of STF claims. STF injury events in hospitals have a myriad of causes and the work conditions in hospitals are diverse. This research provides evidence that implementation of a broad-scale prevention programme can significantly reduce STF injury claims. JF - Ergonomics AU - Bell, Jennifer AU - Collins, James AU - Wolf, Laurie AU - Gronqvist, Raoul AU - Chiou, Sharon AU - Chang, Wen-Ruey AU - Sorock, Gary AU - Courtney, Theodore AU - Lombardi, David AU - Evanoff, Bradley AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1906 EP - 1925 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 51 IS - 12 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Injuries KW - Occupational safety KW - prevention KW - Ergonomics KW - workers' compensation KW - Ice KW - Falls KW - Snow KW - longitudinal studies KW - emergency medical services KW - Hospitals KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20694750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Evaluation+of+a+comprehensive+slip%2C+trip+and+fall+prevention+programme+for+hospital+employees&rft.au=Bell%2C+Jennifer%3BCollins%2C+James%3BWolf%2C+Laurie%3BGronqvist%2C+Raoul%3BChiou%2C+Sharon%3BChang%2C+Wen-Ruey%3BSorock%2C+Gary%3BCourtney%2C+Theodore%3BLombardi%2C+David%3BEvanoff%2C+Bradley&rft.aulast=Bell&rft.aufirst=Jennifer&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=1906&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130802248092 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Hospitals; Injuries; Falls; Occupational safety; prevention; emergency medical services; Ice; longitudinal studies; Ergonomics; Snow; workers' compensation DO - http://dx.doi.org/10.1080/00140130802248092 ER - TY - JOUR T1 - Footwear effects on walking balance at elevation AN - 20694714; 10271013 AB - The study evaluated the effects of shoe style on workers' instability during walking at elevation. Twenty-four construction workers performed walking tasks on roof planks in a surround-screen virtual reality system, which simulated a residential roof environment. Three common athletic and three work shoe styles were tested on wide, narrow and tilted planks on a simulated roof and on an unrestricted surface at simulated ground. Dependent variables included lateral angular velocities of the trunk and the rear foot, as well as the workers' rated perceptions of instability. The results demonstrated that shoe style significantly affected workers walking instability at elevated work environments. The results highlighted two major shoe-design pathways for improving walking balance at elevation: enhancing rear foot motion control; and improving ankle proprioception. This study also outlined some of the challenges in optimal shoe selection and specific shoe-design needs for improved walking stability during roof work. The study adds to the knowledge in the area of balance control, by emphasising the role of footwear as a critical human-support surface interface during work on narrow surfaces at height. The results can be used for footwear selection and improvements to reduce risk of falls from elevation. JF - Ergonomics AU - Simeonov, Peter AU - Hsiao, Hongwei AU - Powers, John AU - Ammons, Douglas AU - Amendola, Alfred AU - Kau, Tsui-Ying AU - Cantis, Douglas AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1885 EP - 1905 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 51 IS - 12 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Risk reduction KW - working conditions KW - risk reduction KW - Construction industry KW - Ergonomics KW - Working conditions KW - Perception KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20694714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Footwear+effects+on+walking+balance+at+elevation&rft.au=Simeonov%2C+Peter%3BHsiao%2C+Hongwei%3BPowers%2C+John%3BAmmons%2C+Douglas%3BAmendola%2C+Alfred%3BKau%2C+Tsui-Ying%3BCantis%2C+Douglas&rft.aulast=Simeonov&rft.aufirst=Peter&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=1885&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130802562625 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Risk reduction; Occupational health; Ergonomics; Working conditions; Perception; Construction industry; risk reduction; working conditions DO - http://dx.doi.org/10.1080/00140130802562625 ER - TY - JOUR T1 - Record-linkage and capture-recapture analysis to estimate the incidence and completeness of reporting of tuberculosis in England 1999-2002 AN - 20594339; 9293886 AB - In 1999 the Enhanced Tuberculosis Surveillance (ETS) system was introduced in the United Kingdom to strengthen surveillance of tuberculosis (TB). The aim of this study was to assess the use of record-linkage and capture-recapture methodology for estimating the completeness of TB reporting in England between 1999 and 2002. Due to the size of the TB data sources sophisticated record-linkage software was required and the proportion of false-positive cases among unlinked hospital-derived TB records was estimated through a population mixture model. This study showed that record-linkage of TB data sources and cross-validation with additional TB-related datasets improved data quality as well as case ascertainment. Since the introduction of ETS observed completeness of notification in England has increased and the results were consistent with expected levels of under-notification. Completeness of notification estimated by a log-linear capture-recapture model was highly inconsistent with prior estimates and the validity of this methodology was further examined. JF - Epidemiology and Infection AU - VAN HEST, NAH AU - Story, A AU - Grant, Ad AU - Antoine, D AU - Crofts, J P AU - Watson, J M AD - Tuberculosis Control Section, Division of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands, vanhestr@ggd.rotterdam.nl Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1606 EP - 1616 PB - Cambridge University Press, The Edinburgh Building, VL - 136 IS - 12 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology KW - Computer programs KW - software KW - Data processing KW - Mycobacterium KW - Tuberculosis KW - Models KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20594339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Record-linkage+and+capture-recapture+analysis+to+estimate+the+incidence+and+completeness+of+reporting+of+tuberculosis+in+England+1999-2002&rft.au=VAN+HEST%2C+NAH%3BStory%2C+A%3BGrant%2C+Ad%3BAntoine%2C+D%3BCrofts%2C+J+P%3BWatson%2C+J+M&rft.aulast=VAN+HEST&rft.aufirst=NAH&rft.date=2008-12-01&rft.volume=136&rft.issue=12&rft.spage=1606&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268808000496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Data processing; Tuberculosis; Models; Mycobacterium DO - http://dx.doi.org/10.1017/S0950268808000496 ER - TY - JOUR T1 - Adaptive stretch-shortening contractions: diminished regenerative capacity with aging AN - 20575317; 9280115 AB - This study determined the age-related changes in acute events responsible for initiating skeletal muscle remodeling and (or) regeneration in the tibialis anterior muscle following a bout of stretch-shortening contractions (SSCs). Changes in muscle performance and morphology were quantified in young and old rats, following an acute exposure to adaptive SSCs at 6, 24, 48, 72, and 120 h postexposure (n = 6 for each age at each recovery period). Following SSC exposure, all performance measures were decreased in old rats throughout the 120 h acute phase. Estimates of edema were increased in the old vs. young exposed muscle at 120 h recovery. Both young and old rats displayed an increase in developmental myosin heavy chain (MHC sub(dev) super(+)) labeling in the exposed muscle, indicating muscle regeneration. However, old rats displayed diminished MHC sub(dev) super(+) labeling, compared with young rats, suggesting limited remodeling and (or) regenerative capacity. Based on these data, diminished local muscle remodeling and (or) regeneration with aging may limit skeletal muscle adaptation following mechanical loading.Original Abstract: Cette etude se propose de determiner les evenements immediats qui sont associes au vieillissement et qui declenchent le remodelage et (ou) regeneration du muscle jambier anterieur apres une serie d'actions d'etirement-contraction (SSCs). On evalue chez des rats jeunes et ages les variations de performance musculaire et les modifications morphologiques observees 6, h, 24 h, 48 h, 72 h et 120 h apres les breves expositions aux SSCs a caractere adaptatif (n = 6 par groupe d'age et par periode de recuperation). Apres l'exposition au SSCs, on observe durant les 120 h d'adaptation une baisse de performance chez les rats ages. D'apres des estimations, le degre de l'[oeligdeme observe 120 h apres l'exposition aux SSCs est plus prononce chez les rats ages que chez les jeunes rats. On observe tant chez les jeunes rats que chez les plus ages une augmentation du marquage de la chaine lourde de myosine en croissance (MHC sub(dev) super(+)), signe de regeneration musculaire. Cependant, on observe moins de marquage de la MHC sub(dev) super(+) chez les rats ages comparativement aux jeunes rats, ce qui suggere une diminution de la capacite de remodelage et (ou) regeneration chez ces premiers. D'apres ces observations, la diminution de la capacite de remodelage et (ou) regeneration observee avec le vieillissement semble limiter l'adaptation du muscle au chargement mecanique. JF - Applied Physiology, Nutrition, and Metabolism AU - Baker, Brent A AU - Hollander, Melinda S AU - Mercer, Robert R AU - Kashon, Michael L AU - Cutlip, Robert G AD - National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26505, USA., rgc8@cdc.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1181 EP - 1191 PB - NRC Research Press VL - 33 IS - 6 SN - 1715-5312, 1715-5312 KW - Physical Education Index KW - aging KW - muscle regeneration KW - inflammation KW - myosin heavy chain KW - stretch-shortening contractions KW - vieillissement KW - regeneration musculaire KW - chaine lourde de myosine KW - actions d'etirement-contraction KW - Muscles (function) KW - Recovery KW - Animal subjects KW - Muscles KW - Edema KW - Performance KW - Muscles (contractions) KW - Nutrition KW - Youth KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20575317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=Comparisons+of+Two+Agreement+Measures&rft.au=Liu%2C+Weimin%3BGallas%2C+Brandon+D&rft.aulast=Liu&rft.aufirst=Weimin&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Muscles (function); Recovery; Animal subjects; Muscles; Edema; Performance; Muscles (contractions); Nutrition; Youth DO - http://dx.doi.org/10.1139/H08-110 ER - TY - JOUR T1 - Statistical Application and Challenges in Global Gel-Free Proteomic Analysis by Mass Spectrometry AN - 20531755; 9218323 AB - Global gel-free proteomic analysis by mass spectrometry has been widely used as an important tool for exploring complex biological systems at the whole genome level. Simultaneous analysis of a large number of protein species is a complicated and challenging task. The challenges exist throughout all stages of a global gel-free proteomic analysis: experimental design, peptide/protein identification, data preprocessing and normalization, and inferential analysis. In addition to various efforts to improve the analytical technologies, statistical methodologies have been applied in all stages of proteomic analyses to help extract relevant information efficiently from large proteomic datasets. In this review, we summarize current applications of statistics in several stages of global gel-free proteomic analysis by mass spectrometry. We discuss the challenges associated with the applications of various statistical tools. Whenever possible, we also propose potential solutions on how to improve the data collection and interpretation for mass-spectrometry-based global proteomic analysis using more sophisticated and/or novel statistical approaches. JF - Critical Reviews in Biotechnology AU - Nie, Lei AU - Wu, Gang AU - Zhang, Weiwen AD - Division of Biometrics IV, Office of Biometrics/CDER/OTS/FDA, Spring, MD, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 297 EP - 307 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 28 IS - 4 SN - 0738-8551, 0738-8551 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Statistics KW - Data processing KW - Information processing KW - Reviews KW - Statistical analysis KW - proteomics KW - Data collections KW - Mass spectroscopy KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20531755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Biotechnology&rft.atitle=Statistical+Application+and+Challenges+in+Global+Gel-Free+Proteomic+Analysis+by+Mass+Spectrometry&rft.au=Nie%2C+Lei%3BWu%2C+Gang%3BZhang%2C+Weiwen&rft.aulast=Nie&rft.aufirst=Lei&rft.date=2008-12-01&rft.volume=28&rft.issue=4&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Critical+Reviews+in+Biotechnology&rft.issn=07388551&rft_id=info:doi/10.1080%2F07388550802543158 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; Statistics; Reviews; Information processing; Statistical analysis; Data collections; proteomics; Mass spectroscopy DO - http://dx.doi.org/10.1080/07388550802543158 ER - TY - JOUR T1 - Utility of Adaptive Strategy and Adaptive Design for Biomarker-facilitated Patient Selection in Pharmacogenomic or Pharmacogenetic Clinical Development Program AN - 20367575; 9048861 AB - In the early to late phases of conventional clinical trials, improvement of disease status at study baseline is the anchor of an effective treatment measured by therapeutic response. These population-based clinical trials do not formally account for disease-associated marker genotype or genome-associated therapeutic response. We discuss alternative study designs in pharmacogenomic or pharmacogenetic clinical trials for genomic or genetic biomarker development, and for formally assessing the clinical utility of genomic or genetic (composite) biomarkers. A two-stage adaptive strategy from completed, ongoing or prospectively planned pharmacogenomic or pharmacogenetic clinical trials is described for development of a genomic or genetic biomarker. We present two types of adaptive design: (1) the genomic biomarker is developed external to the clinical trial, which is designed for treatment effect inference; and (2) first-stage data are used to explore a genomic biomarker, but statistical inference of treatment effect in the genomically or genetically defined biomarker subset is only performed at the second stage of the same trial. When the null hypothesis of no treatment effect in all randomized patients and the genomic patient subset are prospectively specified, we compare the statistical power between fixed and adaptive designs. We also compare the two types of adaptive design. Results from simulation studies showed that adaptive design is more powerful than fixed design for those genomic or genetic biomarkers whose clinical utility is predictive of treatment effect. Pursuit of adaptive design gains at least 20% to more than 30% genomic patient subset power when the genomic biomarker status is readily usable at study initiation, in comparison to when it is explored using the first-stage data of the same clinical trial. In exploratory studies, adaptive strategy provides wide flexibility in the process of genomic or genetic biomarker development. In contrast, an adaptive design trial that employs limited flexibility, and is an adequate and well-controlled investigation, has a greater power gain than a fixed design trial, in which the genomic biomarker is capable of predicting treatment effects that pertain only to the prespecified genomic or genetic patient subset. JF - Journal of the Formosan Medical Association AU - Wang, S-J AD - Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, US FDA, HFD-700, WO 21, Mail Stop Room 3562, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA, suejane.wang@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - S19 EP - S27 VL - 107 IS - 12 SN - 0929-6646, 0929-6646 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Statistics KW - pharmacogenomics KW - genomics KW - Genotypes KW - biomarkers KW - Clinical trials KW - Pharmacogenetics KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20367575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Formosan+Medical+Association&rft.atitle=Utility+of+Adaptive+Strategy+and+Adaptive+Design+for+Biomarker-facilitated+Patient+Selection+in+Pharmacogenomic+or+Pharmacogenetic+Clinical+Development+Program&rft.au=Wang%2C+S-J&rft.aulast=Wang&rft.aufirst=S-J&rft.date=2008-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Statistics; Data processing; pharmacogenomics; Genotypes; genomics; Clinical trials; biomarkers; Pharmacogenetics ER - TY - JOUR T1 - AN ANTIBODY MODIFIED AUTOMATED ENZYME-LINKED IMMUNOSORBENT ASSAY-BASED METHOD FOR DETECTION OF STAPHYLOCOCCAL ENTEROTOXIN* AN - 20303004; 8910407 AB - ABSTRACTStudies were conducted with an automated enzyme-linked immunosorbent assay (ELISA)-based method (Vidas, Staph enterotoxin-II [SET-II]), exhibiting an antibody capture that had undergone modification by removal of the Fc fragment on the antibody. Raw liquid or shell eggs containing a nontoxin component with an attraction to the staphylococcal antienterotoxins were studied. Prior to ELISA testing, the eggs were homogenized and extracts collected by centrifugation. Studies showed that regardless of the ELISA-based method used that utilized the unmodified antibodies with both the Fab1+Fc fragments intact, positive (false positive) ELISA responses occurred with fertilized egg yolks and fertilized whole liquid or whole shell eggs. Conversely, when modified (Fab1) antibodies were used, the automated SET-II enzyme-linked fluorescent immunoassay was negative.PRACTICAL APPLICATIONSMost enzyme-linked immunosorbent assays as well as other serological systems use the whole antibody that has not undergone modification for the detection of the staphylococcal enterotoxins. The use of whole antibody (Fab1+Fc fragments) has on occasion produced false positive results. However, the antibody in which the Fc fragment has been removed leaving the Fab1 fragment provides a more specific antibody for the identification of this microbial toxin. The use of modified antibody (Fab1 fragment) represents significant improvement in antibody quality thus ensuring a greater degree of specificity without sacrificing the sensitivity of serological methods for the detection of staphylococcal enterotoxin in foods. JF - Journal of Rapid Methods and Automation in Microbiology AU - Bennett, Reginald W AD - Food and Drug Administration5100 Paint Branch ParkwayCollege Park, MD 20740-3835 Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 320 EP - 329 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 16 SN - 1060-3999, 1060-3999 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Fc KW - Centrifugation KW - Antibodies KW - Enzyme-linked immunosorbent assay KW - Food KW - Automation KW - Shells KW - Eggs KW - Immunosorbents KW - Toxins KW - Yolk KW - A 01490:Miscellaneous KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20303004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rapid+Methods+and+Automation+in+Microbiology&rft.atitle=AN+ANTIBODY+MODIFIED+AUTOMATED+ENZYME-LINKED+IMMUNOSORBENT+ASSAY-BASED+METHOD+FOR+DETECTION+OF+STAPHYLOCOCCAL+ENTEROTOXIN*&rft.au=Bennett%2C+Reginald+W&rft.aulast=Bennett&rft.aufirst=Reginald&rft.date=2008-12-01&rft.volume=16&rft.issue=&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rapid+Methods+and+Automation+in+Microbiology&rft.issn=10603999&rft_id=info:doi/10.1111%2Fj.1745-4581.2008.00138.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Centrifugation; Fc; Enzyme-linked immunosorbent assay; Antibodies; Food; Automation; Shells; Toxins; Immunosorbents; Eggs; Yolk DO - http://dx.doi.org/10.1111/j.1745-4581.2008.00138.x ER - TY - JOUR T1 - Equivalence-by-Design: Targeting In Vivo Drug Delivery Profile AN - 20282440; 8929508 AB - Abstract In the United States (U.S.), drug products are considered therapeutically equivalent if they meet regulatory criteria of pharmaceutical equivalence and bioequivalence. These requirements can be traced back to 1977 when the U.S. Food and Drug Administration (FDA) published the regulations on bioavailability and bioequivalence. Over the years, to keep up with the advancement in science and technology, the FDA has been constantly updating the regulatory approaches to assessing and ensuring equivalence. In view of the recent growth in novel pharmaceutical dosage forms and delivery systems, this paper examines the current framework for documentation of therapeutic equivalence and explores the opportunities of further advancing equivalence methods for complex drug products. It is proposed that equivalence may be established by matching the in vivo drug delivery profile (iDDP) between drug products in comparison. This can be achieved by characterizing the iDDP of the reference formulation with application of an equivalence-by-design approach for pharmaceutical development. Critical variables can be identified to serve as in vitro markers or biomarkers for mapping the desired drug delivery profile in vivo. A multidisciplinary approach may be necessary to develop these markers for characterization of iDDPs. JF - Pharmaceutical Research AU - Chen, Mei-Ling AU - Lee, Vincent HL AD - Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland, 20993-0002, USA, meiling.chen@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2723 EP - 2730 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 25 IS - 12 SN - 0724-8741, 0724-8741 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Bioavailability KW - Pharmaceuticals KW - Mapping KW - biomarkers KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20282440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+Research&rft.atitle=Equivalence-by-Design%3A+Targeting+In+Vivo+Drug+Delivery+Profile&rft.au=Chen%2C+Mei-Ling%3BLee%2C+Vincent+HL&rft.aulast=Chen&rft.aufirst=Mei-Ling&rft.date=2008-12-01&rft.volume=25&rft.issue=12&rft.spage=2723&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+Research&rft.issn=07248741&rft_id=info:doi/10.1007%2Fs11095-008-9743-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bioavailability; Drug delivery; Pharmaceuticals; Mapping; biomarkers DO - http://dx.doi.org/10.1007/s11095-008-9743-8 ER - TY - JOUR T1 - 10th Anniversary Critical Review: Naturally occurring asbestos AN - 20254787; 8879256 AB - Asbestos is a naturally occurring mineral in the Earth's crust, and it is not confined to the historic and current asbestos mining areas, but rather quite commonly encountered in certain geological environments across the world. That diseases developed as a result of high exposures suffered by miners and asbestos products workers is incontrovertible. In addition, asbestos contamination as a result of past production and use is considered a serious issue where remediation is normally required. However, the risk to health of living on soil and rock where asbestos is encountered as a result of the natural occurrence of small quantities of asbestos minerals is less obvious. The picture becomes even less clear when the minerals are subject to intensive investigation, since our generally accepted definitions of asbestos are themselves put to the test. The discovery of asbestos or related minerals has consequences beyond any immediate risks to health, including profound effects on the value of and ability to use or enjoy property. This review examines the issue of naturally occurring asbestos (NOA) as it has developed in the United States of America and elsewhere, including some superficial insights into the reactions of communities to the presence of NOA. These responses to 'contamination' by nature deserve further in-depth study. JF - Journal of Environmental Monitoring AU - Harper, M AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1394 EP - 1408 VL - 10 IS - 12 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Risk Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Asbestos KW - Bioremediation KW - Occupational safety KW - Earth crust KW - Soil KW - USA KW - Reviews KW - Geology KW - Mining KW - Minerals KW - earth crust KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20254787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=10th+Anniversary+Critical+Review%3A+Naturally+occurring+asbestos&rft.au=Harper%2C+M&rft.aulast=Harper&rft.aufirst=M&rft.date=2008-12-01&rft.volume=10&rft.issue=12&rft.spage=1394&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb810541n LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Soil; Historical account; Asbestos; Bioremediation; Reviews; Occupational safety; Earth crust; Geology; Mining; Minerals; earth crust; USA DO - http://dx.doi.org/10.1039/b810541n ER - TY - JOUR T1 - Sharpening the focus on occupational safety and health in nanotechnology AN - 19922992; 9016296 AB - Increasing numbers of workers are involved with the production, use, distribution, and disposal of nanomaterials. At the same time, there is a growing number of reports of adverse biological effects of engineered nanoparticles in test systems. It is useful, at this juncture, to identify critical questions that will help address knowledge gaps concerning the potential occupational hazards of these materials. The questions address (i) hazard classification of engineered nanoparticles, (ii) exposure metrics, (iii) the actual exposures to the different engineered nanoparticles in the workplace, (iv) the limits of engineering controls and personal protective equipment with respect to engineered nanoparticles, (v) the kinds of surveillance programs that may be required at workplaces to protect potentially exposed workers, (vi) whether exposure registers should be established for workers potentially exposed to engineered nanoparticles, and, (vii) whether engineered nanoparticles should be treated as "new" substances and evaluated for safety and hazards?. JF - Scandinavian Journal of Work, Environment & Health AU - Schulte, P AU - Geraci, C AU - Zumwalde, R AU - Hoover, M AU - Castranova, V AU - Kuempel, E AU - Murashov, V AU - Vainio, H AU - Savolainen, K AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, OH 45226, USA, PSchulte@cdc.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 471 EP - 478 VL - 34 IS - 6 SN - 0355-3140, 0355-3140 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - biological effects KW - Occupational safety KW - Protective equipment KW - Workers KW - safety engineering KW - Classification KW - Occupational hazards KW - nanoparticles KW - Occupational exposure KW - nanotechnology KW - X 24490:Other KW - H 1000:Occupational Safety and Health KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19922992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Sharpening+the+focus+on+occupational+safety+and+health+in+nanotechnology&rft.au=Schulte%2C+P%3BGeraci%2C+C%3BZumwalde%2C+R%3BHoover%2C+M%3BCastranova%2C+V%3BKuempel%2C+E%3BMurashov%2C+V%3BVainio%2C+H%3BSavolainen%2C+K&rft.aulast=Schulte&rft.aufirst=P&rft.date=2008-12-01&rft.volume=34&rft.issue=6&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Workers; Classification; Occupational hazards; nanoparticles; Occupational exposure; nanotechnology; safety engineering; biological effects; Occupational safety; Protective equipment ER - TY - JOUR T1 - A fluorescence detection platform using spatial electroluminescent excitation for measuring botulinum neurotoxin A activity AN - 19892059; 8579451 AB - Current biodetection illumination technologies (laser, LED, tungsten lamp, etc.) are based on spot illumination with additional optics required when spatial excitation is required. Herein we describe a new approach of spatial illumination based on electroluminescence (EL) semiconductor strips available in several wavelengths, greatly simplifying the biosensor design by eliminating the need for additional optics. This work combines EL excitation with charge-coupled device (CCD) based detection (EL-CCD detector) of fluorescence for developing a simple portable detector for botulinum neurotoxin A (BoTN-A) activity analysis. A Forster Resonance Energy Transfer (FRET) activity assay for BoTN-A was used to both characterize and optimize the EL-CCD detector. The system consists of two modules: (1) the detection module which houses the CCD camera and emission filters, and (2) the excitation and sample module, containing the EL strip, the excitation filter and the 9-well sample chip. The FRET activity assay used in this study utilized a FITC/DABCYL-SNAP-25 peptide substrate in which cleavage of the substrate by BoTN-A, or its light chain derivative (LcA), produced an increase in fluorescence emission. EL-CCD detector measured limits of detection (LODs) were similar to those measured using a standard fluorescent plate reader with valves between 0.625 and 1.25nM (31-62ng/ml) for LcA and 0.313nM (45ng/ml) for the full toxin, BoTN-A. As far as the authors are aware this is the first demonstration of phosphor-based EL strips being used for the spatial illumination/excitation of a surface, coupled with CCD for point of care detection. JF - Biosensors and Bioelectronics AU - Sapsford, KE AU - Sun, S AU - Francis, J AU - Sharma, S AU - Kostov, Y AU - Rasooly, A AD - Office of Science and Engineering Laboratories, FDA, Silver Spring, MD 20993, USA, rasoolya@mail.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 618 EP - 625 PB - Elsevier Advanced Technology, 660 White Plains Rd. Tarrytown NY 10591-5153 USA VL - 24 IS - 4 SN - 0956-5663, 0956-5663 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Filters KW - Biosensors KW - Light chains KW - Houses KW - Illumination KW - Cameras KW - fluorescence resonance energy transfer KW - Lasers KW - Botulinum toxin type A KW - Wavelength KW - Tungsten KW - X 24390:Radioactive Materials KW - W 30955:Biosensors KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19892059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=A+fluorescence+detection+platform+using+spatial+electroluminescent+excitation+for+measuring+botulinum+neurotoxin+A+activity&rft.au=Sapsford%2C+KE%3BSun%2C+S%3BFrancis%2C+J%3BSharma%2C+S%3BKostov%2C+Y%3BRasooly%2C+A&rft.aulast=Sapsford&rft.aufirst=KE&rft.date=2008-12-01&rft.volume=24&rft.issue=4&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2008.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Biosensors; Filters; Houses; Light chains; Illumination; Cameras; fluorescence resonance energy transfer; Lasers; Wavelength; Botulinum toxin type A; Tungsten DO - http://dx.doi.org/10.1016/j.bios.2008.06.018 ER - TY - JOUR T1 - Extension-ladder safety: Solutions and knowledge gaps AN - 19812761; 8751239 AB - Falls from ladders are the second leading cause for work-related fatalities in the US construction industry. A significant portion of these incidents occurs at building-construction-and-maintenance worksites during the use of extension ladders. This paper presents the results of a critical literature review related to: (1) risk factors associated with falls from extension ladders, (2) practical engineering solutions that may reduce fall- from-extension-ladder incidents, and (3) questions pertaining to ladder safety that remain unanswered. The review results show that the underlying causes of falls involving extension ladders include the ladder-base slipping out, ladders tipping, workers slipping while on ladders or transitioning from a ladder to a surface at height, and mechanical failures. Some engineering control measures are available in the literature; yet, significant knowledge gaps remain. The knowledge-gap analysis identified four actions needed to advance ladder-safety practice: (1) research on visual indicators to assist in setting up ladders at the correct angle, (2) developing and evaluating measures to ease the transition from a ladder to a surface at heights, (3) integrating ladder accessories into a convertible design to ease the carrying, assembling, and storing of multiple accessories, and thus to encourage safe practices, and (4) developing a graphic-oriented practical guide for safe ladder use, maintenance, and mechanical-flaw detection. Relevance to industry - This paper identified knowledge gaps associated with extension-ladder use for advancing ladder-safety interventions. The development and evaluation of ladder-safety innovations will provide the necessary feedback to ladder manufacturers and ladder-standard-setting bodies for design enhancement and will provide workers practical solutions to reduce injury risks associated with extension-ladder use. JF - International Journal of Industrial Ergonomics AU - Hsiao, H AU - Simeonov, P AU - Pizatella, T AU - Stout, N AU - McDougall, V AU - Weeks, J AD - Protective Technology Branch, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505, USA, hxh4@cdc.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 959 EP - 965 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 38 IS - 11-12 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - intervention KW - Construction industry KW - Ergonomics KW - Mortality KW - Working conditions KW - Maintenance KW - safety engineering KW - Reviews KW - innovations KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19812761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Extension-ladder+safety%3A+Solutions+and+knowledge+gaps&rft.au=Hsiao%2C+H%3BSimeonov%2C+P%3BPizatella%2C+T%3BStout%2C+N%3BMcDougall%2C+V%3BWeeks%2C+J&rft.aulast=Hsiao&rft.aufirst=H&rft.date=2008-12-01&rft.volume=38&rft.issue=11-12&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2008.01.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - safety engineering; Reviews; Mortality; Ergonomics; Maintenance; innovations; Construction industry; Working conditions; intervention; Injuries DO - http://dx.doi.org/10.1016/j.ergon.2008.01.011 ER - TY - JOUR T1 - Examining Associations Between Job Characteristics and Health: Linking Data From the Occupational Information Network (O*NET) to Two U.S. National Health Surveys AN - 19811764; 8902348 AB - Objective: To determine whether the Occupational Information Network (O*NET) database can be used to identify job dimensions to serve as proxy measures for psychosocial factors and select environmental factors, and to determine whether these factors could be linked to national health surveys to examine associations with health risk behaviors and outcomes. Methods: Job characteristics were obtained from O*NET 98. Health outcomes were obtained from two national surveys. Data were linked using Bureau of Census codes. Multiple logistic regression was used to examine associations between O*NET factors and cardiovascular disease, depression, and health risk factors. Results: Seven of nine work organization or psychosocial factors were significantly associated with health risk behaviors in both the National Health and Nutrition Examination Survey III and National Health Interview Survey. Conclusions: This study demonstrates a method for linking independently obtained health and job characteristic data based on occupational code. JF - Journal of Occupational and Environmental Medicine AU - Alterman, T AU - Grosch, J AU - Chen, X AU - Chrislip, D AU - Petersen, M AU - Krieg, E Jr AU - Chung, H AU - Muntaner, C AD - NIOSH (MS-R17), 5555 Ridge Road, Cincinnati, OH 45213, USA, talterman@cdc.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1401 EP - 1413 VL - 50 IS - 12 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - census KW - environmental factors KW - depression KW - Nutrition KW - USA KW - Cardiovascular diseases KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19811764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Examining+Associations+Between+Job+Characteristics+and+Health%3A+Linking+Data+From+the+Occupational+Information+Network+%28O*NET%29+to+Two+U.S.+National+Health+Surveys&rft.au=Alterman%2C+T%3BGrosch%2C+J%3BChen%2C+X%3BChrislip%2C+D%3BPetersen%2C+M%3BKrieg%2C+E+Jr%3BChung%2C+H%3BMuntaner%2C+C&rft.aulast=Alterman&rft.aufirst=T&rft.date=2008-12-01&rft.volume=50&rft.issue=12&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e318188e882 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; census; Nutrition; environmental factors; Cardiovascular diseases; depression DO - http://dx.doi.org/10.1097/JOM.0b013e318188e882 ER - TY - JOUR T1 - Inhibition of Taq polymerase as a method for screening heparin for oversulfated contaminants AN - 19707102; 8599776 AB - Heparin and low molecular heparins are extensively used in the treatment of a wide range of diseases in addition to their classic anticoagulant activity and can be found coating medical devices such as catheters, stents and filters. Early in 2008, a sharp increase in heparin-associated severe adverse events, including over 80 deaths, was linked to the presence of a contaminant identified as hypersulfated chondroitin sulfate (OS-CS). OS-CS is one of several oversulfated glycosaminoglycans (GAGs) of different origins that can potentially cause similar clinical problems underscoring the need to develop robust screening methods for contaminants in existing and future lots of heparin. This study demonstrates that oversulfated GAGs block the activity of Taq polymerase used for real time PCR. Based on this finding we developed a simple, rapid, sensitive and high throughput screening method to detect and quantify oversulfated chondroitin sulfate (OS-CS) and other potential oversulfated contaminants in commercial lots of heparin. This method requires less than 100miliUnits (mU) of heparin as starting material, therefore avoiding the need to lyophilize and concentrate samples, and has a limit of detection of <1ng for all oversulfated GAGs tested. JF - Biomaterials AU - Tami, C AU - Puig, M AU - Reepmeyer, J C AU - Ye, H AU - D'Avignon, DA AU - Buhse, L AU - Verthelyi, D AD - Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drugs Evaluation and Research, Food and Drug Administration, Rockville Pike, Bethesda, MD 20892, United States, daniela.verthelyi@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 4808 EP - 4814 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 29 IS - 36 SN - 0142-9612, 0142-9612 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Filters KW - Chondroitin sulfate KW - Glycosaminoglycans KW - Anticoagulants KW - Catheters KW - Polymerase chain reaction KW - Contaminants KW - Heparin KW - Coatings KW - W 30920:Tissue Engineering KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19707102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Inhibition+of+Taq+polymerase+as+a+method+for+screening+heparin+for+oversulfated+contaminants&rft.au=Tami%2C+C%3BPuig%2C+M%3BReepmeyer%2C+J+C%3BYe%2C+H%3BD%27Avignon%2C+DA%3BBuhse%2C+L%3BVerthelyi%2C+D&rft.aulast=Tami&rft.aufirst=C&rft.date=2008-12-01&rft.volume=&rft.issue=145&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Vital+and+health+statistics.+Series+2%2C+Data+evaluation+and+methods+research&rft.issn=00832057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Filters; Anticoagulants; Glycosaminoglycans; Chondroitin sulfate; Catheters; Polymerase chain reaction; Contaminants; Heparin; Coatings DO - http://dx.doi.org/10.1016/j.biomaterials.2008.08.024 ER - TY - JOUR T1 - Dissociable roles of medial orbitofrontal cortex in human operant extinction learning AN - 19366660; 8752719 AB - Operant extinction, which features modification of instrumental responses to stimuli following a change in associated reinforcement, is an important form of learning for organisms in dynamic environments. Animal studies have highlighted orbital and medial prefrontal cortex and amygdala as mediators of operant extinction. Yet little is known about the neural mediators of operant extinction learning in humans. Using a novel fMRI paradigm, we report dissociable functional responses in distinct regions of medial orbitofrontal cortex (mOFC) during successful appetitive and aversive based operant extinction. During successful operant extinction, increased activity was observed in frontopolar OFC, while decreased activity was observed in caudal mOFC and rostral anterior cingulate cortex (rACC) relative to both (i) successful control trials where the reinforcement associated with the stimulus does not change; and (ii) successful acquisition trials during initial learning of the stimulus-reinforcement associations. Functional connectivity analysis demonstrated inverse connectivity between frontopolar OFC and both rACC and the amygdala. These data support animal models suggesting the importance of mOFC-amygdala interaction during operant extinction and expand our knowledge of the neural systems in humans. These findings suggest that in humans, frontopolar OFC modulates activity in caudal mOFC, rACC and amygdala during successful operant extinction learning. JF - NeuroImage AU - Finger, Elizabeth C AU - Mitchell, Derek GV AU - Jones, Matthew AU - Blair, RJR AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, Elizabeth.Finger@lhsc.on.ca Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 748 EP - 755 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 43 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Learning KW - Data processing KW - Extinction KW - Operant conditioning KW - Neural networks KW - Functional magnetic resonance imaging KW - Animal models KW - Cortex (cingulate) KW - Reinforcement KW - Amygdala KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Dissociable+roles+of+medial+orbitofrontal+cortex+in+human+operant+extinction+learning&rft.au=Finger%2C+Elizabeth+C%3BMitchell%2C+Derek+GV%3BJones%2C+Matthew%3BBlair%2C+RJR&rft.aulast=Finger&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=43&rft.issue=4&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.08.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Operant conditioning; Extinction; Learning; Cortex (prefrontal); Amygdala; Neural networks; Reinforcement; Cortex (cingulate); Data processing; Animal models; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2008.08.021 ER - TY - JOUR T1 - Metabolomics and biomarker discovery: NMR spectral data of urine and hepatotoxicity by carbon tetrachloride, acetaminophen, and d-galactosamine in rats AN - 1709172379; 15622745 AB - The primary objective of this study was to discover biomarkers which are correlated with hepatotoxicity induced by chemicals using super(1)H NMR spectral data of urine. A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition was proposed for early screening of the hepatotoxicity of CCl sub(4), acetaminophen (AAP), and d-galactosamine (GalN) in rats. The hepatotoxic compounds were expected to induce necrosis in hepatocytes. This was confirmed through blood biochemistry and histopathology. CCl sub(4) (1 ml/kg, po) or GalN (0.8 g/kg, ip) was single administered to Sprague-Dawley (S-D) rats and urine was collected every 24 h. Animals were sacrificed 24 h or 48 h post-dosing. AAP (2 g/kg, po) was administered for 2 days and then the animals were sacrificed 24 h after the last treatment. NMR spectroscopy revealed evidently different clustering between control groups and hepatotoxicant treatment groups in global metabolic profilings as indicated by partial least square (PLS)-discrimination analysis (DA). In targeted profilings, endogenous metabolites of allantoin, citrate, taurine, 2-oxoglutarate, acetate, lactate, phenylacetyl glycine, succinate, phenylacetate, 1-methylnicotinamide, hippurate, and benzoate were selected as putative biomarkers for hepatoxicity by CCl sub(4), AAP, and GalN. Comparison of our rat super(1)H NMR PLS-DA data with histopathological changes suggests that super(1)H NMR urinalysis can be used to predict hepatotoxicity induced by CCl sub(4), AAP, and GalN. JF - Metabolomics AU - Kim, Kyu-Bong AU - Chung, Myeon Woo AU - Um, So Young AU - Oh, Ji Seon AU - Kim, Seon Hwa AU - Na, Mi Ae AU - Oh, Hye Young AU - Cho, Wan-Seob AU - Choi, Ki Hwan AD - Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5-Nokbun-dong, Eunpyung-gu, Seoul, 122-704, South Korea, hyokwa@kfda.go.kr Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 377 EP - 392 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 4 IS - 4 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Benzoic acid KW - Hepatocytes KW - Metabolites KW - D-Galactosamine KW - Acetic acid KW - biomarkers KW - hepatotoxicity KW - Taurine KW - Dopamine KW - Urine KW - Magnetic resonance spectroscopy KW - Lactic acid KW - N.M.R. KW - Allantoin KW - Urinalysis KW - metabolomics KW - Acetaminophen KW - Citric acid KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709172379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Metabolomics+and+biomarker+discovery%3A+NMR+spectral+data+of+urine+and+hepatotoxicity+by+carbon+tetrachloride%2C+acetaminophen%2C+and+d-galactosamine+in+rats&rft.au=Kim%2C+Kyu-Bong%3BChung%2C+Myeon+Woo%3BUm%2C+So+Young%3BOh%2C+Ji+Seon%3BKim%2C+Seon+Hwa%3BNa%2C+Mi+Ae%3BOh%2C+Hye+Young%3BCho%2C+Wan-Seob%3BChoi%2C+Ki+Hwan&rft.aulast=Kim&rft.aufirst=Kyu-Bong&rft.date=2008-12-01&rft.volume=4&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-008-0131-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Benzoic acid; Data processing; Hepatocytes; Metabolites; D-Galactosamine; biomarkers; Acetic acid; hepatotoxicity; Taurine; Dopamine; Urine; Magnetic resonance spectroscopy; Lactic acid; N.M.R.; Allantoin; Urinalysis; Acetaminophen; metabolomics; Citric acid DO - http://dx.doi.org/10.1007/s11306-008-0131-5 ER - TY - CPAPER T1 - Quantization Errors in Radiology—Initial Model Observer Results T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41852091; 5060856 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Badano, Aldo Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41852091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=In+Silico+Toxicological+Screening+of+Natural+Products&rft.au=Arvidson%2C+Kirk+B%3BValerio+Jr%2C+Luis+G%3BDiaz%2C+Marilyn%3BChanderbhan%2C+Ronald+F&rft.aulast=Arvidson&rft.aufirst=Kirk&rft.date=2008-02-01&rft.volume=18&rft.issue=2-3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376510701856991 L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Fast, Angle-dependent, Analytical Model of CsI Detector Response for Optimization of 3D Breast Imaging Systems T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41846635; 5061187 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Freed, Melanie AU - Park, Subok AU - Badano, Aldo Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=A+Fast%2C+Angle-dependent%2C+Analytical+Model+of+CsI+Detector+Response+for+Optimization+of+3D+Breast+Imaging+Systems&rft.au=Freed%2C+Melanie%3BPark%2C+Subok%3BBadano%2C+Aldo&rft.aulast=Freed&rft.aufirst=Melanie&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative in Silico Imaging and Biomarker Assessment Using Physical and Computational Phantoms: A Review of New Tools and Methods Available from the NIBIB/CDRH Joint Laboratory for the Assessment of Medical Imaging Systems T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41813348; 5064077 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Badano, Aldo AU - Gavrielides, Marios AU - Kinnard, Lisa AU - Park, Subok AU - Kyprianou, Iacovos AU - Gallas, Brandon Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Bioindicators KW - Reviews KW - Imaging techniques KW - Biomarkers KW - Joints KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41813348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Quantitative+in+Silico+Imaging+and+Biomarker+Assessment+Using+Physical+and+Computational+Phantoms%3A+A+Review+of+New+Tools+and+Methods+Available+from+the+NIBIB%2FCDRH+Joint+Laboratory+for+the+Assessment+of+Medical+Imaging+Systems&rft.au=Badano%2C+Aldo%3BGavrielides%2C+Marios%3BKinnard%2C+Lisa%3BPark%2C+Subok%3BKyprianou%2C+Iacovos%3BGallas%2C+Brandon&rft.aulast=Badano&rft.aufirst=Aldo&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Vascular Motion of Peripheral Arteries in Swine: Toward Predictive Modeling of Clinical Failure Modes T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41806637; 5061575 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Pritchard, William AU - Karanian, John AU - Constante, Edison AU - Chiesa, Oscar AU - Peregoy, Jennifer AU - Esparza, Juan Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Arteries KW - Vascular system KW - Prediction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41806637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Evaluation+of+Vascular+Motion+of+Peripheral+Arteries+in+Swine%3A+Toward+Predictive+Modeling+of+Clinical+Failure+Modes&rft.au=Pritchard%2C+William%3BKaranian%2C+John%3BConstante%2C+Edison%3BChiesa%2C+Oscar%3BPeregoy%2C+Jennifer%3BEsparza%2C+Juan&rft.aulast=Pritchard&rft.aufirst=William&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of X-radiation on Implantable Devices during Multislice CT Scans: Recommendations for Reducing the Risk of Device Malfunctions T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41804379; 5064080 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Kyprianou, Iacovos AU - Badal, Andreu Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Risk reduction KW - Computed tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41804379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Effects+of+X-radiation+on+Implantable+Devices+during+Multislice+CT+Scans%3A+Recommendations+for+Reducing+the+Risk+of+Device+Malfunctions&rft.au=Kyprianou%2C+Iacovos%3BBadal%2C+Andreu&rft.aulast=Kyprianou&rft.aufirst=Iacovos&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A persistent problem with scabies in and outside a nursing home in Amsterdam: indications for resistance to lindane and ivermectin. AN - 69839504; 19040826 AB - An ongoing outbreak of scabies in and outside a nursing home in Amsterdam is described. Despite standard treatment with lindane and ivermectin, many recurrences were observed which suggested resistance to these drugs. After treatment with 5% permethrine, the patients were finally cured. JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin AU - van den Hoek, J A AU - van de Weerd, J A AU - Baayen, T D AU - Molenaar, P M AU - Sonder, G J AU - van Ouwerkerk, I M AU - de Vries, H J AD - Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands. Y1 - 2008/11/27/ PY - 2008 DA - 2008 Nov 27 VL - 13 IS - 48 KW - Insecticides KW - 0 KW - Permethrin KW - 509F88P9SZ KW - Lindane KW - 59NEE7PCAB KW - Ivermectin KW - 70288-86-7 KW - Index Medicus KW - Netherlands -- epidemiology KW - Treatment Failure KW - Insecticides -- administration & dosage KW - Risk Factors KW - Humans KW - Treatment Outcome KW - Nursing Homes -- statistics & numerical data KW - Incidence KW - Drug Resistance KW - Risk Assessment -- methods KW - Population Surveillance KW - Scabies -- prevention & control KW - Ivermectin -- administration & dosage KW - Disease Outbreaks -- prevention & control KW - Permethrin -- administration & dosage KW - Lindane -- administration & dosage KW - Disease Outbreaks -- statistics & numerical data KW - Scabies -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Euro+surveillance+%3A+bulletin+Europeen+sur+les+maladies+transmissibles+%3D+European+communicable+disease+bulletin&rft.atitle=A+persistent+problem+with+scabies+in+and+outside+a+nursing+home+in+Amsterdam%3A+indications+for+resistance+to+lindane+and+ivermectin.&rft.au=van+den+Hoek%2C+J+A%3Bvan+de+Weerd%2C+J+A%3BBaayen%2C+T+D%3BMolenaar%2C+P+M%3BSonder%2C+G+J%3Bvan+Ouwerkerk%2C+I+M%3Bde+Vries%2C+H+J&rft.aulast=van+den+Hoek&rft.aufirst=J&rft.date=2008-11-27&rft.volume=13&rft.issue=48&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Euro+surveillance+%3A+bulletin+Europeen+sur+les+maladies+transmissibles+%3D+European+communicable+disease+bulletin&rft.issn=1560-7917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-27 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical mixtures: evaluation of risk for child-specific exposures in a multi-stressor environment. AN - 69801375; 18353412 AB - Evaluating the health impact from exposure to chemical mixtures is multifaceted. One component is exposure. Exposure, and consequently risk assessment for mixtures and chemicals in general, are often viewed in terms of a given exposure to a given population at a given location over a given time period. However, environmental exposures are present throughout human lifetime. As a result, an evaluation of risk must include the distinctive characteristics related to chemical exposures which will impact risk depending upon the particular life stage where exposure occurs. Risks to offspring may be associated with unique exposures in utero, during infancy, childhood, or adolescent periods. For example, exposure of infants to anthropogenic chemicals via breast milk may be of concern. The Agency for Toxic Substances and Disease Registry's (ATSDR's) approach to evaluating risks associated with exposure to mixtures of chemicals is presented. In addition to the breast milk issues, indoor exposure to combined air pollutants, drinking water contaminants, and soil and dust contaminants are discussed. The difference between a mixture's risk evaluation for children and adults is in the distinct exposure scenarios resulting from variations in behavior, physiology, and/or pharmacokinetics between adults and children rather than in the method for the specific mixtures evaluation per se. JF - Toxicology and applied pharmacology AU - Pohl, H R AU - Abadin, H G AD - Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, Georgia, USA. hrp1@cdc.gov Y1 - 2008/11/15/ PY - 2008 DA - 2008 Nov 15 SP - 116 EP - 125 VL - 233 IS - 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Age Factors KW - Risk Factors KW - Humans KW - Child KW - Hazardous Substances -- pharmacokinetics KW - Environmental Exposure -- adverse effects KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69801375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Chemical+mixtures%3A+evaluation+of+risk+for+child-specific+exposures+in+a+multi-stressor+environment.&rft.au=Pohl%2C+H+R%3BAbadin%2C+H+G&rft.aulast=Pohl&rft.aufirst=H&rft.date=2008-11-15&rft.volume=233&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2008.01.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-12 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Toxicol Appl Pharmacol. 2008 Dec 1;233(2):353; author reply 354 [18692517] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2008.01.015 ER - TY - JOUR T1 - Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo: a novel approach to sensitize prostate cancer to anticancer therapy. AN - 69791093; 19010904 AB - Interleukin-13 (IL-13) receptor alpha2 (IL-13Ralpha2), a high-affinity IL-13 binding subunit and a tumor antigen, is amplified in a variety of human tumor cell lines and tumors in vivo. By cDNA microarray, we have shown that gene transfer of human and rat adrenomedullin (AM) up-regulates IL-13Ralpha2 in a human prostate tumor cell line. Here, we show that IL-13Ralpha2 mRNA and protein are also up-regulated in PC-3 prostate tumor cells by recombinant AM (rAM) and human synthetic AM peptide in a dose-dependent manner in vitro and in vivo in mouse prostate tumor model. The 8- to 10-fold up-regulation of IL-13Ralpha2 by rAM or AM peptide in prostate tumor cells in vitro and in vivo increased their sensitivity to IL-13PE cytotoxin consisting of IL-13 and a truncated form of Pseudomonas exotoxin. Immunodeficient mice with established prostate tumors transfected with AM or treated with AM peptide showed reduction in tumor size by intratumoral administration of IL-13PE in a dose-dependent manner. At the highest dose (three 100 mug/kg/d every alternate day), >70% reduction of tumor size was observed compared with controls (P 6-log inactivation). D-values at 55 to 47.5 degrees C were 15 to 59 s in mango juice and 16 to 105 s in orange juice with z-values of 9.28 and 12.30 degrees C, respectively. These results indicate that current pasteurization parameters used for destroying common foodborne bacterial pathogens are adequate for eliminating F. tularensis in the four foods tested. This study is the first to determine thermal inactivation of F. tularensis in specific foods and will permit comparisons with the thermal inactivation data of other more traditional foodborne pathogens. JF - Journal of food protection AU - Day, J B AU - Trujillo, S AU - Hao, Y Y D AU - Whiting, R C AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-712, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA. james.day@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 2208 EP - 2212 VL - 71 IS - 11 SN - 0362-028X, 0362-028X KW - Index Medicus KW - Infant KW - Malus -- microbiology KW - Consumer Product Safety KW - Humans KW - Infant, Newborn KW - Colony Count, Microbial KW - Fruit KW - Mangifera -- microbiology KW - Citrus sinensis -- microbiology KW - Time Factors KW - Hot Temperature KW - Infant Formula KW - Beverages -- microbiology KW - Food Handling -- methods KW - Food Contamination -- analysis KW - Francisella tularensis -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69850959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Thermal+resistance+of+Francisella+tularensis+in+infant+formula+and+fruit+juices.&rft.au=Day%2C+J+B%3BTrujillo%2C+S%3BHao%2C+Y+Y+D%3BWhiting%2C+R+C&rft.aulast=Day&rft.aufirst=J&rft.date=2008-11-01&rft.volume=71&rft.issue=11&rft.spage=2208&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-02 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. AN - 69825858; 19023402 AB - The major DNA repair pathways operate on damage in double-strand DNA because they use the intact strand as a template after damage removal. Therefore, lesions in transient single-strand stretches of chromosomal DNA are expected to be especially threatening to genome stability. To test this hypothesis, we designed systems in budding yeast that could generate many kilobases of persistent single-strand DNA next to double-strand breaks or uncapped telomeres. The systems allowed controlled restoration to the double-strand state after applying DNA damage. We found that lesions induced by UV-light and methyl methanesulfonate can be tolerated in long single-strand regions and are hypermutagenic. The hypermutability required PCNA monoubiquitination and was largely attributable to translesion synthesis by the error-prone DNA polymerase zeta. In support of multiple lesions in single-strand DNA being a source of hypermutability, analysis of the UV-induced mutants revealed strong strand-specific bias and unexpectedly high frequency of alleles with widely separated multiple mutations scattered over several kilobases. Hypermutability and multiple mutations associated with lesions in transient stretches of long single-strand DNA may be a source of carcinogenesis and provide selective advantage in adaptive evolution. JF - PLoS genetics AU - Yang, Yong AU - Sterling, Joan AU - Storici, Francesca AU - Resnick, Michael A AU - Gordenin, Dmitry A AD - Department of Health and Human Services, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1 VL - 4 IS - 11 KW - DNA, Fungal KW - 0 KW - DNA, Single-Stranded KW - Index Medicus KW - DNA Repair KW - Models, Genetic KW - Ultraviolet Rays -- adverse effects KW - DNA, Fungal -- genetics KW - Genome, Fungal KW - Mutagenesis KW - Saccharomyces cerevisiae -- genetics KW - Telomere -- metabolism KW - Saccharomyces cerevisiae -- metabolism KW - DNA, Single-Stranded -- chemistry KW - DNA Breaks, Double-Stranded -- radiation effects KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69825858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+genetics&rft.atitle=Hypermutability+of+damaged+single-strand+DNA+formed+at+double-strand+breaks+and+uncapped+telomeres+in+yeast+Saccharomyces+cerevisiae.&rft.au=Yang%2C+Yong%3BSterling%2C+Joan%3BStorici%2C+Francesca%3BResnick%2C+Michael+A%3BGordenin%2C+Dmitry+A&rft.aulast=Yang&rft.aufirst=Yong&rft.date=2008-11-01&rft.volume=4&rft.issue=11&rft.spage=e1000264&rft.isbn=&rft.btitle=&rft.title=PLoS+genetics&rft.issn=1553-7404&rft_id=info:doi/10.1371%2Fjournal.pgen.1000264 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-23 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Mol Cell Biol. 2005 Dec;6(12):943-53 [16341080] Genes Dev. 2008 Jan 15;22(2):125-40 [18198332] DNA Repair (Amst). 2006 Feb 3;5(2):258-73 [16310415] J Cell Biol. 2006 Apr 24;173(2):195-206 [16618811] Methods Enzymol. 2006;409:329-45 [16793410] Methods Enzymol. 2006;409:462-76 [16793418] Nat Rev Immunol. 2006 Aug;6(8):573-83 [16868548] EMBO J. 2006 Sep 20;25(18):4316-25 [16957771] Mol Cell Biol. 2006 Oct;26(20):7645-57 [16908537] Annu Rev Genet. 2006;40:209-35 [16805667] Nat Struct Mol Biol. 2007 Mar;14(3):208-14 [17293872] Genetics. 2007 Mar;175(3):1533-7 [17151233] Proc Natl Acad Sci U S A. 2007 May 15;104(20):8403-8 [17485671] Crit Rev Biochem Mol Biol. 2007 Jul-Aug;42(4):247-58 [17687667] Crit Rev Biochem Mol Biol. 2007 Sep-Oct;42(5):313-26 [17917869] Nat Biotechnol. 2001 Aug;19(8):773-6 [11479573] Curr Opin Microbiol. 2001 Oct;4(5):582-5 [11587936] Nucleic Acids Res. 2001 Nov 1;29(21):4414-22 [11691929] Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1437-42 [11818556] Genetics. 2002 Nov;162(3):1063-77 [12454056] DNA Repair (Amst). 2002 Jun 21;1(6):425-35 [12509231] Nat Genet. 2003 Jul;34(3):326-9 [12796780] Nucleic Acids Res. 2003 Aug 1;31(15):4541-52 [12888515] J Cell Sci. 2003 Oct 15;116(Pt 20):4057-65 [12972499] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14994-9 [14630945] J Bacteriol. 1972 Mar;109(3):979-86 [4551759] Mutat Res. 1975 Nov;30(2):209-18 [1107831] Nature. 1979 Aug 2;280(5721):420-3 [223063] Crit Rev Microbiol. 1985;12(2):131-51 [3928261] Cancer Res. 1991 Jun 15;51(12):3075-9 [2039987] Genetics. 1991 Nov;129(3):957-62 [1752431] Genetics. 1995 Jul;140(3):965-72 [7672595] Yeast. 1995 Dec;11(16):1553-73 [8720065] Photochem Photobiol. 1997 Feb;65(2):270-83 [9066304] J Mol Biol. 1999 Jun 25;289(5):1207-18 [10373362] Yeast. 1999 Oct;15(14):1541-53 [10514571] Proc Natl Acad Sci U S A. 1963 Nov;50:975-80 [14082365] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12849-54 [16118275] Biochem Soc Trans. 2007 Nov;35(Pt 5):1334-7 [17956345] DNA Repair (Amst). 2007 Dec 1;6(12):1829-38 [17715002] Nature. 2007 Nov 22;450(7169):509-14 [17965729] Mol Cell. 2007 Dec 14;28(5):739-45 [18082599] Mol Cell. 2006 Jan 6;21(1):15-27 [16387650] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pgen.1000264 ER - TY - JOUR T1 - Intracranial hemorrhage and liver-associated deaths associated with tipranavir/ritonavir: review of cases from the FDA's Adverse Event Reporting System. AN - 69820230; 19025478 AB - Tipranavir (TPV), a protease inhibitor, has box warnings for intracranial hemorrhage (ICH) and hepatotoxicity (including hepatic failure and death). A box warning is a labeling statement about serious adverse events leading to significant injury and/or death. A box warning is the most serious warning placed in the labeling of a prescription medication. As a result of the respective morbidity and mortality associated with ICH and hepatic failure, the Food and Drug Administration's (FDA's) Adverse Event Reporting System (AERS) was searched for reports of these adverse events in HIV-infected patients receiving a tipranavir/ritonavir (TPV/r)-based regimen. This search comprised part of the FDA's safety analysis for traditional approval. From July 2006 to March 2007, 10 cases of ICH were identified in AERS. From June 2005 to March 2007, 12 cases of liver-associated deaths were identified. One patient experienced liver failure and fatal ICH. Most patients with these events had additional risk factors. Among patients with liver-associated deaths, 3 had HIV-RNA less than 400 copies per milliliter at the time of hepatic failure. Among 10 patients who discontinued TPV/r when hepatic failure developed, median number of days post-TPV/r to death was 23 (range, 2-69 days). Review of AERS did not identify new safety concerns regarding ICH. Among most patients with liver-associated deaths, death appears to occur soon after hepatic failure develops. If considering TPV/r, careful assessment of risk/benefit is suggested for patients at risk for ICH and hepatic failure. JF - AIDS patient care and STDs AU - Chan-Tack, Kirk M AU - Struble, Kimberly A AU - Birnkrant, Debra B AD - Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA. kirk.chan-tack@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 843 EP - 850 VL - 22 IS - 11 KW - HIV Protease Inhibitors KW - 0 KW - Pyridines KW - Pyrones KW - Ritonavir KW - O3J8G9O825 KW - tipranavir KW - ZZT404XD09 KW - Index Medicus KW - AIDS/HIV KW - Drug Therapy, Combination KW - United States Food and Drug Administration KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - HIV-1 -- drug effects KW - Male KW - Female KW - HIV Infections -- virology KW - Liver Failure -- mortality KW - Intracranial Hemorrhages -- epidemiology KW - Liver Failure -- epidemiology KW - Intracranial Hemorrhages -- mortality KW - Intracranial Hemorrhages -- chemically induced KW - HIV Infections -- drug therapy KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Liver Failure -- chemically induced KW - Pyrones -- adverse effects KW - HIV Protease Inhibitors -- adverse effects KW - Ritonavir -- adverse effects KW - Pyridines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69820230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Herbal+product+use+by+persons+enrolled+in+the+hepatitis+C+Antiviral+Long-Term+Treatment+Against+Cirrhosis+%28HALT-C%29+Trial.&rft.au=Seeff%2C+Leonard+B%3BCurto%2C+Teresa+M%3BSzabo%2C+Gyongyi%3BEverson%2C+Gregory+T%3BBonkovsky%2C+Herbert+L%3BDienstag%2C+Jules+L%3BShiffman%2C+Mitchell+L%3BLindsay%2C+Karen+L%3BLok%2C+Anna+S+F%3BDi+Bisceglie%2C+Adrian+M%3BLee%2C+William+M%3BGhany%2C+Marc+G%3BHALT-C+Trial+Group&rft.aulast=Seeff&rft.aufirst=Leonard&rft.date=2008-02-01&rft.volume=47&rft.issue=2&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-30 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/apc.2008.0043 ER - TY - JOUR T1 - Determination of dialkyl phosphate metabolites of organophosphorus pesticides in human urine by automated solid-phase extraction, derivatization, and gas chromatography-mass spectrometry. AN - 69814810; 19021926 AB - Organophosphorus (OP) pesticides are highly toxic but used commonly worldwide, nevertheless. Their urinary dialkylphosphate (DAP) metabolites are widely used for exposure assessment of OP pesticides in humans. We previously developed an analytical method to measure urinary DAPs utilizing solid-phase extraction (SPE)-derivatization-gas chromatography-tandem mass spectrometry (GC-MS-MS) with quantification using isotope-dilution technique. We now present a more cost-effective yet highly accurate method that can be easily adaptable to many laboratories for routine OP exposure assessment. This method is simple and fast and involves automated SPE of the metabolites followed by derivatization with pentafluorobenzyl bromide and quantification by GC-MS. Dibutyl phosphate (DBP) serves as the internal standard. The detection limits for the six metabolites ranged from 0.1 to 0.15 ng/mL. Depending on the metabolite the relative standard deviation of the analytical procedure was 2-15% for the metabolites. We compared performance of DBP as an internal standard with that of isotope-labeled compounds and found that DBP gives reliable results for the analytical procedure. We also optimized reaction parameters of pentafluorobenzylation. JF - Journal of analytical toxicology AU - Hemakanthi De Alwis, G K AU - Needham, Larry L AU - Barr, Dana B AD - Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F 17, Atlanta, Georgia 30341, USA. hemakanthi.dealwis@fda.hhs.gov PY - 2008 SP - 721 EP - 727 VL - 32 IS - 9 SN - 0146-4760, 0146-4760 KW - Insecticides KW - 0 KW - Organophosphates KW - Solvents KW - di-n-butylphosphoric acid KW - 107-66-4 KW - Index Medicus KW - Reproducibility of Results KW - Biotransformation KW - Humans KW - Reference Standards KW - Temperature KW - Gas Chromatography-Mass Spectrometry KW - Automation KW - Organophosphates -- urine KW - Insecticides -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69814810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Determination+of+dialkyl+phosphate+metabolites+of+organophosphorus+pesticides+in+human+urine+by+automated+solid-phase+extraction%2C+derivatization%2C+and+gas+chromatography-mass+spectrometry.&rft.au=Hemakanthi+De+Alwis%2C+G+K%3BNeedham%2C+Larry+L%3BBarr%2C+Dana+B&rft.aulast=Hemakanthi+De+Alwis&rft.aufirst=G&rft.date=2008-11-01&rft.volume=32&rft.issue=9&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-06 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The US must help set international standards for nanotechnology. AN - 69766017; 18989319 JF - Nature nanotechnology AU - Murashov, Vladimir AU - Howard, John AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US Department of Health and Human Services, Washington, DC 20201, USA. vladimir.murashov@cdc.hhs.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 635 EP - 636 VL - 3 IS - 11 KW - Index Medicus KW - United States KW - Guideline Adherence -- organization & administration KW - International Agencies -- legislation & jurisprudence KW - Nanostructures -- standards KW - Nanostructures -- adverse effects KW - Humans KW - Reference Standards KW - International Agencies -- organization & administration KW - Guideline Adherence -- legislation & jurisprudence KW - International Cooperation -- legislation & jurisprudence KW - Government Regulation KW - Nanotechnology -- legislation & jurisprudence KW - Risk Management -- trends KW - Nanotechnology -- standards KW - Risk Management -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69766017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+nanotechnology&rft.atitle=The+US+must+help+set+international+standards+for+nanotechnology.&rft.au=Murashov%2C+Vladimir%3BHoward%2C+John&rft.aulast=Murashov&rft.aufirst=Vladimir&rft.date=2008-11-01&rft.volume=25&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2007.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nat Nanotechnol. 2009 Apr;4(4):205; author reply 205-6 [19350019] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nnano.2008.323 ER - TY - JOUR T1 - Role of the N-terminal amino acid of Bacillus anthracis lethal factor in lethal toxin cytotoxicity and its effect on the lethal toxin neutralization assay. AN - 69749996; 18815235 AB - The cytotoxic activity of lethal factor (LF), a critical reagent used in the cell-based lethal toxin neutralization assay to assess anthrax vaccines, was shown to depend on the identity of its N-terminal amino acid, which plays a role in the targeting of LF to the proteasome for degradation. These results demonstrate that care must be taken to ensure that LF preparations used in standardized cell-based assays are not altered at their N-terminal ends. JF - Clinical and vaccine immunology : CVI AU - Verma, Anita AU - Wagner, Leslie AU - Stibitz, Scott AU - Nguyen, Nga AU - Guerengomba, Flor AU - Burns, Drusilla L AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1737 EP - 1741 VL - 15 IS - 11 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - anthrax toxin KW - Index Medicus KW - Animals KW - Neutralization Tests KW - Mice KW - Amino Acid Sequence KW - Cell Line KW - Amino Acid Substitution KW - Bacterial Toxins -- genetics KW - Antigens, Bacterial -- toxicity KW - Bacterial Toxins -- toxicity KW - Macrophages -- drug effects KW - Antigens, Bacterial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69749996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+vaccine+immunology+%3A+CVI&rft.atitle=Role+of+the+N-terminal+amino+acid+of+Bacillus+anthracis+lethal+factor+in+lethal+toxin+cytotoxicity+and+its+effect+on+the+lethal+toxin+neutralization+assay.&rft.au=Verma%2C+Anita%3BWagner%2C+Leslie%3BStibitz%2C+Scott%3BNguyen%2C+Nga%3BGuerengomba%2C+Flor%3BBurns%2C+Drusilla+L&rft.aulast=Verma&rft.aufirst=Anita&rft.date=2008-11-01&rft.volume=15&rft.issue=11&rft.spage=1737&rft.isbn=&rft.btitle=&rft.title=Clinical+and+vaccine+immunology+%3A+CVI&rft.issn=1556-679X&rft_id=info:doi/10.1128%2FCVI.00081-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-01 N1 - Date created - 2008-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 2000 Apr;68(4):1781-6 [10722564] Infect Immun. 2007 Nov;75(11):5135-47 [17682039] Vaccine. 2001 Sep 14;19(32):4768-73 [11535328] Vaccine. 2004 Jan 2;22(3-4):422-30 [14670324] Biologicals. 2004 Mar;32(1):17-27 [15026022] J Infect Dis. 2004 Oct 1;190(7):1228-36 [15346332] Science. 1986 Oct 10;234(4773):179-86 [3018930] Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12142-9 [8901547] Infect Immun. 1998 Feb;66(2):862-5 [9453657] Science. 1998 May 1;280(5364):734-7 [9563949] Biochem Biophys Res Commun. 1998 Jul 30;248(3):706-11 [9703991] Biochemistry. 1998 Nov 10;37(45):15737-46 [9843379] Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16756-61 [15548616] J Bacteriol. 2005 May;187(9):3133-8 [15838040] Vaccine. 2006 Aug 14;24(33-34):5950-9 [16797805] Hum Vaccin. 2007 Sep-Oct;3(5):205-11 [17881903] Protein Expr Purif. 2000 Apr;18(3):293-302 [10733882] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/CVI.00081-08 ER - TY - JOUR T1 - Populations of p53 codon 270 CGT to TGT mutant cells in SKH-1 mouse skin tumors induced by simulated solar light. AN - 69740608; 18381587 AB - The p53 codon 270 CGT to TGT mutation was investigated as a biomarker of sunlight-induced mutagenesis and carcinogenesis. The relationship between tumor development and abundance of this hotspot mutation was analyzed in mouse skin tumors induced by chronic exposure to simulated solar light (SSL). The 24 tumors analyzed had similar growth kinetics, with an average doubling time of approximately 16.4 d. Levels of the p53 codon 270 mutation were quantified in the 24 mouse skin tumors using allele-specific competitive blocker-polymerase chain reaction (ACB-PCR). All tumors contained measurable amounts of the mutation. The p53 codon 270 CGT to TGT mutant fraction (MF) ranged from 2.29 x 10(-3) to 9.42 x 10(-2), with 3.26 x 10(-2) as the median. These p53 MF measurements are lower than expected for an initiating mutation involved in the development of tumors of monoclonal origin. There was no evidence of a correlation between p53 codon 270 MF and either tumor area or an estimate of tumor cell number. Thus, the data do not support the idea that p53 mutation accumulates linearly during tumor development. To investigate how p53 mutation was distributed within tumors, 19 needle biopsies from seven different tumors were analyzed by ACB-PCR. This analysis demonstrated that p53 codon 270 mutation is heterogeneously distributed within tumors. The long-term goal of this research is to combine morphological and p53 MF measurements from tissues corresponding to the various stages of tumor development, in order to derive mathematical models relating the p53 codon 270 mutation to the development of SSL-induced skin tumors. JF - Molecular carcinogenesis AU - Verkler, Tracie L AU - Delongchamp, Robert R AU - Couch, Letha H AU - Miller, Barbara J AU - Warbritton, Alan AU - Mellick, Paul W AU - Howard, Paul C AU - Parsons, Barbara L AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, USFDA, Jefferson, Arkansas 72079, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 822 EP - 834 VL - 47 IS - 11 KW - Codon KW - 0 KW - RNA, Messenger KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Animals KW - Base Sequence KW - Cell Transformation, Neoplastic -- radiation effects KW - Cell Transformation, Neoplastic -- metabolism KW - Sunlight KW - Mutation -- genetics KW - Mice KW - RNA, Messenger -- genetics KW - Cell Transformation, Neoplastic -- genetics KW - Skin Neoplasms -- genetics KW - Codon -- genetics KW - Neoplasms, Radiation-Induced -- pathology KW - Neoplasms, Radiation-Induced -- metabolism KW - Skin Neoplasms -- pathology KW - Neoplasms, Radiation-Induced -- genetics KW - Tumor Suppressor Protein p53 -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Skin Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69740608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Populations+of+p53+codon+270+CGT+to+TGT+mutant+cells+in+SKH-1+mouse+skin+tumors+induced+by+simulated+solar+light.&rft.au=Verkler%2C+Tracie+L%3BDelongchamp%2C+Robert+R%3BCouch%2C+Letha+H%3BMiller%2C+Barbara+J%3BWarbritton%2C+Alan%3BMellick%2C+Paul+W%3BHoward%2C+Paul+C%3BParsons%2C+Barbara+L&rft.aulast=Verkler&rft.aufirst=Tracie&rft.date=2008-11-01&rft.volume=47&rft.issue=11&rft.spage=822&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.20439 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20439 ER - TY - JOUR T1 - Estimation of required monitoring time for obtaining validation data in enclosed spaces. AN - 69733687; 18974904 AB - Methods for estimating airborne contaminant concentrations at specific locations within enclosed spaces, such as mathematical models and computational fluid dynamics (CFD), often are validated against directly measured concentrations. However, concentration variation with time introduces uncertainty into the measured concentration. Failure to determine monitoring time requirements can lead to errors in quantifying representative concentrations, which are likely to be attributed to errors in the method being validated. In the current study, to obtain the representative concentrations at multiple locations with a direct reading instrument, we used the standard deviation ratio (SDR) method to determine the required minimum monitoring time within a specified precision limit. To demonstrate the use of the SDR approach in constructing precision confidence intervals, tracer gas concentrations at nine sampling locations in an experimental room were measured to obtain population parameters. Three flow rates of 0.9, 3.3 and 5.5 m(3) min(-1) were employed and contaminant concentrations were measured using a photoionization analyser. Monitoring time requirements varied substantially with location within the room and were strongly dependent upon the flow rate of air through the room. The proposed method would be very useful for industrial hygienists and indoor air researchers who sometimes need to obtain several hundred measured concentrations for validation purposes or to perform tests under repeatable conditions in enclosed spaces. This study also showed that the proposed method can be used to devise efficient indoor monitoring strategies. JF - Journal of environmental monitoring : JEM AU - Lee, Eun Gyung AU - Feigley, Charles E AU - Hussey, James R AU - Slaven, James E AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. dtq5@cdc.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1350 EP - 1356 VL - 10 IS - 11 KW - Air Pollutants KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Spectrometry, Fluorescence KW - Reproducibility of Results KW - Spectrophotometry, Ultraviolet KW - Calorimetry KW - Air Pollutants -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69733687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Estimation+of+required+monitoring+time+for+obtaining+validation+data+in+enclosed+spaces.&rft.au=Lee%2C+Eun+Gyung%3BFeigley%2C+Charles+E%3BHussey%2C+James+R%3BSlaven%2C+James+E&rft.aulast=Lee&rft.aufirst=Eun&rft.date=2008-11-01&rft.volume=10&rft.issue=11&rft.spage=1350&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=1464-0333&rft_id=info:doi/10.1039%2Fb806421k LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/b806421k ER - TY - JOUR T1 - Routine diagnostic X-ray examinations and increased frequency of chromosome translocations among U.S. radiologic technologists. AN - 69732606; 18974125 AB - The U.S. population has nearly one radiographic examination per person per year, and concern about cancer risks associated with medical radiation has increased. Radiologic technologists were surveyed to determine whether their personal cumulative exposure to diagnostic X-rays was associated with increased frequencies of chromosome translocations, an established radiation biomarker and possible intermediary suggesting increased cancer risk. Within a large cohort of U.S. radiologic technologists, 150 provided a blood sample for whole chromosome painting and were interviewed about past X-ray examinations. The number and types of examinations reported were converted to a red bone marrow (RBM) dose score with units that approximated 1 mGy. The relationship between dose score and chromosome translocation frequency was assessed using Poisson regression. The estimated mean cumulative RBM radiation dose score was 49 (range, 0-303). After adjustment for age, translocation frequencies significantly increased with increasing RBM dose score with an estimate of 0.004 translocations per 100 cell equivalents per score unit (95% confidence interval, 0.002-0.007; P < 0.001). Removing extreme values or adjustment for gender, cigarette smoking, occupational radiation dose, allowing practice X-rays while training, work with radioisotopes, and radiotherapy for benign conditions did not affect the estimate. Cumulative radiation exposure from routine X-ray examinations was associated independently with increased chromosome damage, suggesting the possibility of elevated long-term health risks, including cancer. The slope estimate was consistent with expectation based on cytogenetic experience and atomic bomb survivor data. JF - Cancer research AU - Sigurdson, Alice J AU - Bhatti, Parveen AU - Preston, Dale L AU - Doody, Michele Morin AU - Kampa, Diane AU - Alexander, Bruce H AU - Petibone, Dayton AU - Yong, Lee C AU - Edwards, Alan A AU - Ron, Elaine AU - Tucker, James D AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. sigurdsa@mail.nih.gov Y1 - 2008/11/01/ PY - 2008 DA - 2008 Nov 01 SP - 8825 EP - 8831 VL - 68 IS - 21 KW - Index Medicus KW - United States KW - Aged, 80 and over KW - Humans KW - Cohort Studies KW - In Situ Hybridization, Fluorescence KW - Aged KW - Dose-Response Relationship, Radiation KW - Male KW - Female KW - Occupational Exposure KW - Technology, Radiologic -- manpower KW - Translocation, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69732606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Routine+diagnostic+X-ray+examinations+and+increased+frequency+of+chromosome+translocations+among+U.S.+radiologic+technologists.&rft.au=Sigurdson%2C+Alice+J%3BBhatti%2C+Parveen%3BPreston%2C+Dale+L%3BDoody%2C+Michele+Morin%3BKampa%2C+Diane%3BAlexander%2C+Bruce+H%3BPetibone%2C+Dayton%3BYong%2C+Lee+C%3BEdwards%2C+Alan+A%3BRon%2C+Elaine%3BTucker%2C+James+D&rft.aulast=Sigurdson&rft.aufirst=Alice&rft.date=2008-11-01&rft.volume=68&rft.issue=21&rft.spage=8825&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1691 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-08 N1 - Date created - 2008-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiat Res. 1998 Jun;149(6):602-13 [9611099] Radiat Res. 2008 Aug;170(2):149-55 [18666821] Radiat Res. 1999 Dec;152(6):655-64 [10581536] Radiat Res. 2001 Oct;156(4):337-46 [11554845] Int J Radiat Biol. 2001 Aug;77(8):901-8 [11571024] Radiat Prot Dosimetry. 2001;97(3):279-82; discussion 285 [11843345] Health Phys. 2002 Apr;82(4):455-66 [11906134] Health Phys. 2002 Dec;83(6):907-17 [12467299] Int J Cancer. 2003 Feb 10;103(4):556-62 [12478675] Health Phys. 2003 Feb;84(2):245-59 [12553655] Radiat Prot Dosimetry. 2003;103(1):35-40 [12596987] Am J Epidemiol. 2003 Apr 1;157(7):652-63 [12672685] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Health Phys. 2003 Jul;85(1):47-59 [12852471] Radiat Prot Dosimetry. 2003;106(2):131-5 [14653333] Lancet. 2004 Jan 31;363(9406):345-51 [15070562] Mutat Res. 1999 Jun 25;442(2):89-95 [10393277] Radiat Res. 2004 Sep;162(3):249-56 [15378837] Radiat Res. 2004 Oct;162(4):377-89 [15447045] Phys Med Biol. 1981 May;26(3):389-400 [7243876] Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7474-6 [1881886] Int J Radiat Biol. 1992 Jul;62(1):53-63 [1353776] Radiology. 1993 Nov;189(2):377-80 [8210363] Health Phys. 1995 Feb;68(2):266-9 [7814260] Cytogenet Cell Genet. 1995;68(3-4):211-21 [7842739] Mutat Res. 1995 Oct;338(1-6):95-106 [7565886] Mutagenesis. 1995 Nov;10(6):487-95 [8596467] Environ Health Perspect. 1996 May;104 Suppl 3:489-92 [8781370] Radiat Res. 1997 Sep;148(3):216-26 [9291352] Environ Mol Mutagen. 1997;30(3):264-72 [9366904] Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):229-48 [15657915] Radiat Prot Dosimetry. 2005;113(4):396-402 [15928034] Radiat Res. 2005 Nov;164(5):612-7 [16238438] Occup Environ Med. 2005 Dec;62(12):861-7 [16299095] Cancer. 2006 Jun 15;106(12):2707-15 [16639729] Radiat Res. 2006 Jul;166(1 Pt 2):174-92 [16808606] JAMA. 2006 Aug 9;296(6):638-40 [16896096] Mutat Res. 2006 Aug 30;600(1-2):37-45 [16814813] Radiat Res. 2007 Jun;167(6):727-34 [17523852] JAMA. 2007 Jul 18;298(3):317-23 [17635892] N Engl J Med. 2007 Nov 29;357(22):2277-84 [18046031] Mutat Res. 2008 Apr 30;652(2):112-21 [18337160] Radiology. 2008 Jul;248(1):254-63 [18566177] Int J Radiat Biol. 1998 Nov;74(5):565-71 [9848275] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1691 ER - TY - JOUR T1 - An evaluation of a data mining signal for amyotrophic lateral sclerosis and statins detected in FDA's spontaneous adverse event reporting system. AN - 69728074; 18821724 AB - We detected disproportionate reporting of amyotrophic lateral sclerosis (ALS) with HMG-CoA-reductase inhibitors (statins) in the Food and Drug Administration's (FDA) spontaneous adverse event (AE) reporting system (AERS). To describe the original ALS signal and to provide additional context for interpreting the signal by conducting retrospective analyses of data from long-term, placebo-controlled clinical trials of statins. The ALS signal was detected using the multi-item gamma Poisson shrinker (MGPS) algorithm. All AERS cases of ALS reported in association with use of a statin were individually reviewed by two FDA neurologists. Manufacturers of lovastatin, pravastatin, simvastatin, fluvastatin, atorvastatin, cerivastatin, and rosuvastatin were requested to provide the number of cases of ALS diagnosed during all of their placebo-controlled statin trials that were at least 6 months in duration. There were 91 US and foreign reports of ALS with statins in AERS. The data mining signal scores for ALS and statins ranged from 8.5 to 1.6. Data were obtained from 41 statin clinical trials ranging in duration from 6 months to 5 years and representing approximately 200,000 patient-years of exposure to statin and approximately 200,000 patient-years of exposure to placebo. Nine cases of ALS were reported in statin-treated patients and 10 cases in placebo-treated patients. Although we observed a data mining signal for ALS with statins in FDA's AERS, retrospective analyses of 41 statin clinical trials did not reveal an increased incidence of ALS in subjects treated with a statin compared with placebo. Copyright (c) 2008 John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and drug safety AU - Colman, Eric AU - Szarfman, Ana AU - Wyeth, Jo AU - Mosholder, Andrew AU - Jillapalli, Devanand AU - Levine, Jonathan AU - Avigan, Mark AD - Division of Metabolism and Endocrinology Products, United States Food and Drug Administration, Silver Spring, MD 20993, USA. eric.colman@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1068 EP - 1076 VL - 17 IS - 11 KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - 0 KW - Index Medicus KW - Controlled Clinical Trials as Topic KW - Aged, 80 and over KW - Humans KW - Adult KW - Retrospective Studies KW - Product Surveillance, Postmarketing KW - Algorithms KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - United States Food and Drug Administration -- statistics & numerical data KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Amyotrophic Lateral Sclerosis -- epidemiology KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Amyotrophic Lateral Sclerosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69728074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=An+evaluation+of+a+data+mining+signal+for+amyotrophic+lateral+sclerosis+and+statins+detected+in+FDA%27s+spontaneous+adverse+event+reporting+system.&rft.au=Colman%2C+Eric%3BSzarfman%2C+Ana%3BWyeth%2C+Jo%3BMosholder%2C+Andrew%3BJillapalli%2C+Devanand%3BLevine%2C+Jonathan%3BAvigan%2C+Mark&rft.aulast=Colman&rft.aufirst=Eric&rft.date=2008-11-01&rft.volume=17&rft.issue=11&rft.spage=1068&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=1099-1557&rft_id=info:doi/10.1002%2Fpds.1643 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-11 N1 - Date created - 2008-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pds.1643 ER - TY - JOUR T1 - Optical mapping and 454 sequencing of Escherichia coli O157 : H7 isolates linked to the US 2006 spinach-associated outbreak. AN - 69722725; 18957604 AB - Optical maps for five representative clinical, food-borne and bovine-derived isolates from the 2006 Escherichia coli O157 : H7 outbreak linked to fresh spinach in the United States showed a common set of 14 distinct chromosomal markers that define the outbreak strain. Partial 454 DNA sequencing was used to characterize the optically mapped chromosomal markers. The markers included insertions, deletions, substitutions and a simple single nucleotide polymorphism creating a BamHI site. The Shiga toxin gene profile of the spinach-associated outbreak isolates (stx1(-) stx2(+) stx2c(+)) correlated with prophage insertions different from those in the prototypical EDL933 and Sakai reference strains (stx1(+) stx2(+) stx2c(-)). The prophage occupying the yehV chromosomal position in the spinach-associated outbreak isolates was similar to the stx1(+) EDL933 cryptic prophage V, but it lacked the stx1 gene. In EDL933, the stx2 genes are within prophage BP933-W at the wrbA chromosomal locus; this locus was unoccupied in the spinach outbreak isolates. Instead, the stx2 genes were found within a chimeric BP933-W-like prophage with a different integrase, inserted at the argW locus in the outbreak isolates. An extra set of Shiga toxin genes, stx2c, was found in the outbreak isolates within a prophage integrated at the sbcB locus. The optical maps of two additional clinical isolates from the outbreak showed a single, different prophage variation in each, suggesting that changes occurred in the source strain during the course of this widespread, multi-state outbreak. JF - Microbiology (Reading, England) AU - Kotewicz, Michael L AU - Mammel, Mark K AU - LeClerc, J Eugene AU - Cebula, Thomas A AD - Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 3518 EP - 3528 VL - 154 SN - 1350-0872, 1350-0872 KW - Shiga Toxins KW - 0 KW - Index Medicus KW - Animals KW - Prophages -- genetics KW - Food Microbiology KW - Cattle -- microbiology KW - Polymorphism, Genetic KW - Humans KW - Shiga Toxins -- genetics KW - Food Contamination -- analysis KW - Chromosomes, Bacterial -- genetics KW - United States -- epidemiology KW - Escherichia coli Infections -- microbiology KW - Escherichia coli Infections -- epidemiology KW - Escherichia coli O157 -- isolation & purification KW - Restriction Mapping KW - Spinacia oleracea -- microbiology KW - Escherichia coli O157 -- virology KW - Disease Outbreaks KW - Escherichia coli O157 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69722725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+%28Reading%2C+England%29&rft.atitle=Optical+mapping+and+454+sequencing+of+Escherichia+coli+O157+%3A+H7+isolates+linked+to+the+US+2006+spinach-associated+outbreak.&rft.au=Kotewicz%2C+Michael+L%3BMammel%2C+Mark+K%3BLeClerc%2C+J+Eugene%3BCebula%2C+Thomas+A&rft.aulast=Kotewicz&rft.aufirst=Michael&rft.date=2008-11-01&rft.volume=154&rft.issue=&rft.spage=3518&rft.isbn=&rft.btitle=&rft.title=Microbiology+%28Reading%2C+England%29&rft.issn=13500872&rft_id=info:doi/10.1099%2Fmic.0.2008%2F019026-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-22 N1 - Date created - 2008-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1099/mic.0.2008/019026-0 ER - TY - JOUR T1 - Amoxicillin for postexposure inhalational anthrax in pediatrics: rationale for dosing recommendations. AN - 69719402; 18833025 AB - We reviewed information about the safety and plasma pharmacokinetic data for amoxicillin, specifically related to its potential use for postexposure inhalational anthrax. Amoxicillin (45 mg/kg/d) given orally in 3 divided doses to pediatric patients <40 kg should yield an adequate time above the MIC for susceptible Bacillus anthracis (< or =0.5 microg/mL) over most of the dosing interval (75-100%). Doses <45 mg/kg/d and dosing intervals longer than 8 hours should not be used for postexposure inhalational anthrax. JF - The Pediatric infectious disease journal AU - Alexander, John J AU - Colangelo, Philip M AU - Cooper, Charles K AU - Roberts, Rosemary AU - Rodriguez, William J AU - Murphy, Mary D AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 955 EP - 957 VL - 27 IS - 11 SN - 0891-3668, 0891-3668 KW - Amoxicillin KW - 804826J2HU KW - Index Medicus KW - Infant KW - Humans KW - Infant, Newborn KW - Child KW - Microbial Sensitivity Tests KW - Child, Preschool KW - Bacillus anthracis -- drug effects KW - Amoxicillin -- therapeutic use KW - Amoxicillin -- administration & dosage KW - Inhalation Exposure KW - Amoxicillin -- pharmacokinetics KW - Amoxicillin -- adverse effects KW - Anthrax -- prevention & control KW - Anthrax -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69719402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Pediatric+infectious+disease+journal&rft.atitle=Amoxicillin+for+postexposure+inhalational+anthrax+in+pediatrics%3A+rationale+for+dosing+recommendations.&rft.au=Alexander%2C+John+J%3BColangelo%2C+Philip+M%3BCooper%2C+Charles+K%3BRoberts%2C+Rosemary%3BRodriguez%2C+William+J%3BMurphy%2C+Mary+D&rft.aulast=Alexander&rft.aufirst=John&rft.date=2008-11-01&rft.volume=27&rft.issue=11&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=The+Pediatric+infectious+disease+journal&rft.issn=08913668&rft_id=info:doi/10.1097%2FINF.0b013e31817bf9a9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-01 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/INF.0b013e31817bf9a9 ER - TY - JOUR T1 - Antimicrobial resistance in Salmonella enterica serovar Heidelberg isolates from retail meats, including poultry, from 2002 to 2006. AN - 69714800; 18757574 AB - Salmonella enterica serovar Heidelberg frequently causes food-borne illness in humans. There are few data on the prevalence, antimicrobial susceptibility, and genetic diversity of Salmonella serovar Heidelberg isolates in retail meats. We compared the prevalences of Salmonella serovar Heidelberg in a sampling of 20,295 meats, including chicken breast (n = 5,075), ground turkey (n = 5,044), ground beef (n = 5,100), and pork chops (n = 5,076), collected during 2002 to 2006. Isolates were analyzed for antimicrobial susceptibility and compared genetically using pulsed-field gel electrophoresis (PFGE) and PCR for the bla(CMY) gene. A total of 298 Salmonella serovar Heidelberg isolates were recovered, representing 21.6% of all Salmonella serovars from retail meats. One hundred seventy-eight (59.7%) were from ground turkey, 110 (36.9%) were from chicken breast, and 10 (3.4%) were from pork chops; none was found in ground beef. One hundred ninety-eight isolates (66.4%) were resistant to at least one compound, and 49 (16.4%) were resistant to at least five compounds. Six isolates (2.0%), all from ground turkey, were resistant to at least nine antimicrobials. The highest resistance in poultry isolates was to tetracycline (39.9%), followed by streptomycin (37.8%), sulfamethoxazole (27.7%), gentamicin (25.7%), kanamycin (21.5%), ampicillin (19.8%), amoxicillin-clavulanic acid (10.4%), and ceftiofur (9.0%). All isolates were susceptible to ceftriaxone and ciprofloxacin. All ceftiofur-resistant strains carried bla(CMY). PFGE using XbaI and BlnI showed that certain clones were widely dispersed in different types of meats and meat brands from different store chains in all five sampling years. These data indicate that Salmonella serovar Heidelberg is a common serovar in retail poultry meats and includes widespread clones of multidrug-resistant strains. JF - Applied and environmental microbiology AU - Zhao, S AU - White, D G AU - Friedman, S L AU - Glenn, A AU - Blickenstaff, K AU - Ayers, S L AU - Abbott, J W AU - Hall-Robinson, E AU - McDermott, P F AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD 20708, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 6656 EP - 6662 VL - 74 IS - 21 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Swine KW - Animals KW - Turkeys KW - DNA Fingerprinting KW - Drug Resistance, Multiple, Bacterial KW - beta-Lactamases -- genetics KW - Polymerase Chain Reaction KW - Cattle KW - Chickens KW - Meat Products -- microbiology KW - DNA, Bacterial -- genetics KW - Electrophoresis, Gel, Pulsed-Field KW - Microbial Sensitivity Tests KW - Prevalence KW - Salmonella enterica -- isolation & purification KW - Drug Resistance, Bacterial KW - Salmonella enterica -- genetics KW - Food Contamination KW - Anti-Bacterial Agents -- pharmacology KW - Meat -- microbiology KW - Salmonella enterica -- classification KW - Salmonella enterica -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69714800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Antimicrobial+resistance+in+Salmonella+enterica+serovar+Heidelberg+isolates+from+retail+meats%2C+including+poultry%2C+from+2002+to+2006.&rft.au=Zhao%2C+S%3BWhite%2C+D+G%3BFriedman%2C+S+L%3BGlenn%2C+A%3BBlickenstaff%2C+K%3BAyers%2C+S+L%3BAbbott%2C+J+W%3BHall-Robinson%2C+E%3BMcDermott%2C+P+F&rft.aulast=Zhao&rft.aufirst=S&rft.date=2008-11-01&rft.volume=74&rft.issue=21&rft.spage=6656&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.01249-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 2001 Dec;45(12):3647-50 [11709361] Foodborne Pathog Dis. 2008 Apr;5(2):115-26 [18361686] Ann Saudi Med. 2004 Jul-Aug;24(4):270-2 [15387492] JAMA. 1980 Feb 8;243(6):546-7 [7351786] MMWR Morb Mortal Wkly Rep. 1986 Feb 14;35(6):91 [3080662] Epidemiol Infect. 1989 Oct;103(2):227-34 [2806415] J Am Geriatr Soc. 1990 May;38(5):531-4 [2332575] J Emerg Med. 1990 May-Jun;8(3):295-7 [2373838] Clin Infect Dis. 1995 Oct;21(4):1065 [8645823] Infect Control Hosp Epidemiol. 1997 Feb;18(2):115-21 [9120239] World Health Stat Q. 1997;50(1-2):81-9 [9282390] Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25 [10511517] Epidemiol Infect. 2005 Oct;133(5):809-16 [16181499] Foodborne Pathog Dis. 2006 Spring;3(1):59-67 [16602980] Foodborne Pathog Dis. 2006 Spring;3(1):106-17 [16602986] J Food Prot. 2006 May;69(5):1150-3 [16715818] PLoS One. 2007;2(3):e309 [17375195] J Food Prot. 2007 Jun;70(6):1328-33 [17612059] J Antimicrob Chemother. 2007 Aug;60(2):398-401 [17526503] Antimicrob Agents Chemother. 2004 Aug;48(8):2845-52 [15273090] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.01249-08 ER - TY - JOUR T1 - Method for estimating ultraviolet germicidal fluence rates in a hospital room. AN - 69704664; 18844468 AB - Upper-room air UV germicidal irradiation (UVGI) is an effective environmental control measure for mitigating the transmission of airborne infections. Many factors influence the efficacy of an upper-room air UVGI system, including the levels and distribution of radiation. The radiation levels experienced by airborne microorganisms can be estimated by measuring the fluence rate, which is the irradiance from all angles that is incident on a small region of space. The fluence rate can be estimated by use of a radiometer coupled to a planar detector. Measurements in 4 directions at a single point are taken and summed to estimate the fluence rate at that point. This measurement process is repeated at different sites in the room at a single height. In the upper air of a test room, the UV fluence rate varied at least 3-fold, with the maximum rate occurring in the immediate vicinity of the fixtures containing lamps emitting UV radiation. In the area that would be occupied by the patient and/or healthcare personnel, no significant variation occurred in the UV fluence rate for a designated height. There was no significant statistical difference between measurements obtained by different individuals, by using a different alignment, or during 5 observation periods. Lamp failures were detected on multiple occasions. This method is simple, requires no specialized training, and permits regular monitoring of the necessary UV fluence rates needed to sustain the targeted airborne microorganisms' inactivation level. Additionally, this method allowed for the detection of changes in UV fluence rates in the upper air of the simulated hospital room. JF - Infection control and hospital epidemiology AU - Schafer, Millie P AU - Kujundzic, Elmira AU - Moss, Clyde E AU - Miller, Shelly L AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1099, USA. mps3@cdc.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1042 EP - 1047 VL - 29 IS - 11 KW - Index Medicus KW - Nursing KW - Radiometry KW - Patients' Rooms KW - Air Pollution, Indoor -- prevention & control KW - Ultraviolet Rays KW - Infection Control -- standards KW - Infection Control -- methods KW - Infection Control -- instrumentation KW - Air Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69704664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+control+and+hospital+epidemiology&rft.atitle=Method+for+estimating+ultraviolet+germicidal+fluence+rates+in+a+hospital+room.&rft.au=Schafer%2C+Millie+P%3BKujundzic%2C+Elmira%3BMoss%2C+Clyde+E%3BMiller%2C+Shelly+L&rft.aulast=Schafer&rft.aufirst=Millie&rft.date=2008-11-01&rft.volume=29&rft.issue=11&rft.spage=1042&rft.isbn=&rft.btitle=&rft.title=Infection+control+and+hospital+epidemiology&rft.issn=1559-6834&rft_id=info:doi/10.1086%2F591856 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/591856 ER - TY - JOUR T1 - Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. AN - 69693934; 18725543 AB - Emerging evidence suggests that the rewarding, abuse-related effects of nicotine are modulated by the endocannabinoid system of the brain. For example, pharmacological blockade or genetic deletion of cannabinoid CB(1) receptors can reduce or eliminate many abuse-related behavioral and neurochemical effects of nicotine. Furthermore, doses of Delta(9)-tetrahydrocannabinol and nicotine that are ineffective when given alone can induce conditioned place preference when given together. These previous studies have used systemically administered CB(1) receptor agonists and antagonists and gene deletion techniques, which affect cannabinoid CB(1) receptors throughout the brain. A more functionally selective way to alter endocannabinoid activity is to inhibit fatty acid amide hydrolase (FAAH), thereby magnifying and prolonging the effects of the endocannabinoid anandamide only when and where it is synthesized and released on demand. Here, we combined behavioral and neurochemical approaches to evaluate whether the FAAH inhibitor URB597 (cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester) could alter the abuse-related effects of nicotine in rats. We found that URB597, at a dose (0.3 mg/kg) that had no behavioral effects by itself, prevented development of nicotine-induced conditioned place preference (CPP) and acquisition of nicotine self-administration. URB597 also reduced nicotine-induced reinstatement in both CPP and self-administration models of relapse. Furthermore, in vivo microdialysis showed that URB597 reduced nicotine-induced dopamine elevations in the nucleus accumbens shell, the terminal area of the brain's mesolimbic reward system. These findings suggest that FAAH inhibition can counteract the addictive properties of nicotine and that FAAH may serve as a new target for development of medications for treatment of tobacco dependence. JF - The Journal of pharmacology and experimental therapeutics AU - Scherma, Maria AU - Panlilio, Leigh V AU - Fadda, Paola AU - Fattore, Liana AU - Gamaleddin, Islam AU - Le Foll, Bernard AU - Justinová, Zuzana AU - Mikics, Eva AU - Haller, Jozsef AU - Medalie, Julie AU - Stroik, Jessica AU - Barnes, Chanel AU - Yasar, Sevil AU - Tanda, Gianluigi AU - Piomelli, Daniele AU - Fratta, Walter AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 482 EP - 490 VL - 327 IS - 2 KW - Arachidonic Acids KW - 0 KW - Benzamides KW - Carbamates KW - Endocannabinoids KW - Polyunsaturated Alkamides KW - cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester KW - Nicotine KW - 6M3C89ZY6R KW - Amidohydrolases KW - EC 3.5.- KW - fatty-acid amide hydrolase KW - EC 3.5.1.- KW - anandamide KW - UR5G69TJKH KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Self Administration KW - Rats, Long-Evans KW - Reward KW - Motor Activity -- drug effects KW - Hydrolysis KW - Male KW - Carbamates -- pharmacology KW - Nucleus Accumbens -- chemistry KW - Nucleus Accumbens -- drug effects KW - Arachidonic Acids -- metabolism KW - Polyunsaturated Alkamides -- metabolism KW - Conditioning (Psychology) -- drug effects KW - Benzamides -- pharmacology KW - Tobacco Use Disorder -- drug therapy KW - Amidohydrolases -- physiology KW - Nicotine -- pharmacology KW - Dopamine -- analysis KW - Amidohydrolases -- antagonists & inhibitors KW - Tobacco Use Disorder -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69693934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Inhibition+of+anandamide+hydrolysis+by+cyclohexyl+carbamic+acid+3%27-carbamoyl-3-yl+ester+%28URB597%29+reverses+abuse-related+behavioral+and+neurochemical+effects+of+nicotine+in+rats.&rft.au=Scherma%2C+Maria%3BPanlilio%2C+Leigh+V%3BFadda%2C+Paola%3BFattore%2C+Liana%3BGamaleddin%2C+Islam%3BLe+Foll%2C+Bernard%3BJustinov%C3%A1%2C+Zuzana%3BMikics%2C+Eva%3BHaller%2C+Jozsef%3BMedalie%2C+Julie%3BStroik%2C+Jessica%3BBarnes%2C+Chanel%3BYasar%2C+Sevil%3BTanda%2C+Gianluigi%3BPiomelli%2C+Daniele%3BFratta%2C+Walter%3BGoldberg%2C+Steven+R&rft.aulast=Scherma&rft.aufirst=Maria&rft.date=2008-11-01&rft.volume=327&rft.issue=2&rft.spage=482&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.142224 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nicotine Tob Res. 1999;1 Suppl 2:S121-5; discussion S139-40 [11768168] Br J Pharmacol. 2002 Jan;135(2):564-78 [11815392] Neuropharmacology. 2002 Oct;43(5):857-67 [12384171] Behav Pharmacol. 2002 Sep;13(5-6):451-63 [12394421] Brain Res. 2002 Nov 1;954(1):73-81 [12393235] J Neurobiol. 2002 Dec;53(4):606-17 [12436424] Nat Med. 2003 Jan;9(1):76-81 [12461523] Eur J Neurosci. 2003 Apr;17(8):1723-6 [12752390] Synapse. 2003 Oct;50(1):1-6 [12872287] J Biol Chem. 2003 Aug 15;278(33):30429-34 [12761211] Science. 2003 Oct 3;302(5642):84-8 [14526074] Curr Drug Targets CNS Neurol Disord. 2003 Dec;2(6):389-402 [14683467] J Neurosci. 2004 Jan 7;24(1):53-62 [14715937] J Med Chem. 2004 Oct 7;47(21):4998-5008 [15456244] Neuroreport. 2004 Sep 15;15(13):2139-43 [15486497] Eur J Pharmacol. 1987 Sep 23;141(3):395-9 [3666033] Psychopharmacology (Berl). 1989;99(4):473-8 [2594913] Brain Res. 1994 Aug 8;653(1-2):278-84 [7982062] Nature. 1994 Dec 15;372(6507):686-91 [7990962] Nature. 1996 Jul 18;382(6588):255-7 [8717040] Psychopharmacology (Berl). 1997 Jan;129(1):35-43 [9122361] Psychopharmacology (Berl). 1997 Apr;130(4):396-403 [9160857] Nature. 1998 Jan 8;391(6663):173-7 [9428762] Behav Pharmacol. 1997 Dec;8(8):707-12 [9832956] Psychopharmacology (Berl). 2005 Apr;178(4):481-92 [15765262] J Pharmacol Exp Ther. 2005 Apr;313(1):352-8 [15579492] Pharmacol Biochem Behav. 2005 Jun;81(2):381-6 [15925402] Nature. 2005 Jul 7;436(7047):103-7 [16001069] Psychopharmacology (Berl). 2005 Oct;181(4):722-34 [15986197] AAPS J. 2005;7(3):E625-54 [16353941] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18620-5 [16352709] Psychopharmacology (Berl). 2006 Mar;184(3-4):367-81 [16205918] Psychopharmacology (Berl). 2006 Mar;184(3-4):339-44 [16416156] CNS Drug Rev. 2006 Spring;12(1):21-38 [16834756] J Pharmacol Exp Ther. 2006 Aug;318(2):563-70 [16702440] Curr Opin Lipidol. 2007 Apr;18(2):129-40 [17353660] Mol Pharmacol. 2007 Oct;72(4):1024-32 [17628012] Br J Pharmacol. 2007 Nov;152(5):734-43 [17906680] Biol Psychiatry. 2007 Nov 15;62(10):1103-10 [17511970] Neuropharmacology. 2008 Jan;54(1):129-40 [17904589] Neuropharmacology. 2008 Feb;54(2):438-44 [18054052] J Neurochem. 2008 May;105(4):1235-43 [18194436] J Pharmacol Exp Ther. 2008 Aug;326(2):483-92 [18451315] Biol Psychiatry. 2008 Dec 1;64(11):930-7 [18814866] Erratum In: J Pharmacol Exp Ther. 2011 Jun;337(3):887 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.142224 ER - TY - JOUR T1 - Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabant. AN - 69671876; 18305459 AB - Accumulating evidence suggests the endocannabinoid system modulates environmental cues' ability to induce seeking of drugs, including nicotine and alcohol. However, little attention has been directed toward extending these advances to the growing problem of cannabis use disorders. Therefore, we studied intravenous self-administration of Delta(9)-tetrahydrocannabinol (THC), the main psychoactive constituent of marijuana, using a second-order schedule of drug seeking. Squirrel monkeys' lever responses produced only a brief cue light until the end of the session, when the final response delivered THC along with the cue. When a reinstatement procedure was used to model relapse following a period of abstinence, THC-seeking behavior was robustly reinstated by the cue or by pre-session administration of THC, other cannabinoid agonists, or morphine, but not cocaine. The cannabinoid antagonist rimonabant blocked cue-induced drug seeking, THC-induced drug seeking, and the direct reinforcing effects of THC. Thus, rimonabant and related medications might be effective as treatments for cannabinoid dependence. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Justinova, Zuzana AU - Munzar, Patrik AU - Panlilio, Leigh V AU - Yasar, Sevil AU - Redhi, Godfrey H AU - Tanda, Gianluigi AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Department of Health and Human Services, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 2870 EP - 2877 VL - 33 IS - 12 KW - Analgesics, Opioid KW - 0 KW - Cannabinoid Receptor Modulators KW - Piperidines KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - Morphine KW - 76I7G6D29C KW - Dronabinol KW - 7J8897W37S KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Reinforcement (Psychology) KW - Disease Models, Animal KW - Cannabinoid Receptor Modulators -- antagonists & inhibitors KW - Morphine -- pharmacology KW - Saimiri KW - Cannabinoid Receptor Modulators -- agonists KW - Self Administration KW - Cannabinoid Receptor Modulators -- metabolism KW - Analgesics, Opioid -- pharmacology KW - Cues KW - Secondary Prevention KW - Male KW - Piperidines -- pharmacology KW - Brain -- physiopathology KW - Pyrazoles -- pharmacology KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Marijuana Abuse -- metabolism KW - Brain Chemistry -- drug effects KW - Brain -- drug effects KW - Marijuana Abuse -- drug therapy KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Brain -- metabolism KW - Marijuana Abuse -- physiopathology KW - Dronabinol -- antagonists & inhibitors KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69671876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Blockade+of+THC-seeking+behavior+and+relapse+in+monkeys+by+the+cannabinoid+CB%281%29-receptor+antagonist+rimonabant.&rft.au=Justinova%2C+Zuzana%3BMunzar%2C+Patrik%3BPanlilio%2C+Leigh+V%3BYasar%2C+Sevil%3BRedhi%2C+Godfrey+H%3BTanda%2C+Gianluigi%3BGoldberg%2C+Steven+R&rft.aulast=Justinova&rft.aufirst=Zuzana&rft.date=2008-11-01&rft.volume=33&rft.issue=12&rft.spage=2870&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.21 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2006 Aug 16;26(33):8531-6 [16914679] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Brain Res Rev. 2007 Jan;53(1):1-16 [16839608] Behav Pharmacol. 2007 Feb;18(1):61-9 [17218798] Eur J Neurosci. 2007 Apr;25(7):2191-200 [17419755] Psychopharmacology (Berl). 2005 May;179(2):452-60 [15821957] J Neurosci. 2005 Jun 8;25(23):5645-50 [15944392] Pharmacol Biochem Behav. 2005 Jun;81(2):285-99 [15932767] Pharmacol Biochem Behav. 2005 Jun;81(2):387-95 [15935455] Trends Pharmacol Sci. 2005 Aug;26(8):420-6 [15992935] Psychopharmacology (Berl). 2006 Jan;183(4):394-403 [16261315] Trends Neurosci. 2006 Apr;29(4):225-32 [16483675] Addiction. 2007 Dec;102(12):1863-70 [18031422] Nat Neurosci. 2000 Nov;3(11):1073-4 [11036260] Behav Pharmacol. 2000 Aug;11(5):377-86 [11103889] Psychopharmacology (Berl). 2000 Dec;153(1):17-30 [11255926] J Neurosci. 2001 Jul 15;21(14):5344-50 [11438610] Nat Med. 2001 Oct;7(10):1151-4 [11590440] Psychopharmacology (Berl). 2002 Oct;163(3-4):327-44 [12373434] Behav Pharmacol. 2002 Sep;13(5-6):451-63 [12394421] J Pharmacol Exp Ther. 2003 Jul;306(1):93-102 [12660305] Psychopharmacology (Berl). 2003 Jul;168(1-2):164-9 [12669182] Psychopharmacology (Berl). 2003 Sep;169(2):135-40 [12827345] Psychopharmacology (Berl). 2004 Apr;173(1-2):186-94 [14668977] JAMA. 2004 May 5;291(17):2114-21 [15126440] Br J Pharmacol. 2004 Oct;143(3):343-50 [15339858] J Pharmacol Exp Ther. 1973 Jul;186(1):18-30 [4198773] Fed Proc. 1975 Aug;34(9):1771-6 [1149889] Psychopharmacology (Berl). 1977 Mar 16;51(3):235-42 [403538] Psychopharmacology (Berl). 1998 Dec;140(3):331-44 [9877013] Pharmacol Biochem Behav. 1999 Oct;64(2):327-36 [10515309] Neuropsychopharmacology. 2006 Dec;31(12):2652-9 [16541083] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.21 ER - TY - JOUR T1 - Characteristics of grandmothers who have grandchildren with fetal alcohol syndrome or incomplete fetal alcohol syndrome. AN - 69634019; 18196450 AB - Characteristics of Northern Plains American Indian maternal grandmothers who had grandchildren with fetal alcohol syndrome (FAS) or incomplete FAS are described to more effectively prevent fetal FAS and alcohol use during pregnancy. Study 1 had 27 maternal grandmothers who had grandchildren with FAS and Study 2 had 18 grandmothers with grandchildren who had incomplete FAS (cases) which were compared with 119 maternal grandmothers who had grandchildren without FAS (controls). The grandchildren were born between 1981 and 1993 on the Northern Plains. Medical records were manually reviewed for each case and control grandmother. Data were analyzed using Mantel-Haenszel chi square. Study 1 case grandmothers were more likely to experience medical problems (70.4%) including trauma (48.1%) and injuries (51.9%) than the controls. Most of the Study 1 and 2 case grandmothers (92.6% and 77.8%, respectively) had alcohol use documented in their medical records compared to less than half of the control grandmothers. Seven (15.6%) of the case grandmothers had more than one grandchild in either Study 1 or Study 2. Maternal grandmothers who had grandchildren with FAS had significantly higher rates of alcohol use and alcohol-related medical problems than control grandmothers. Antenatal care providers should screen pregnant women for alcohol use at their first visit. The provider needs to ask the women who are using alcohol about their mothers' use of alcohol to provide appropriate care and counseling for the women and prevent FAS. JF - Maternal and child health journal AU - Kvigne, Valborg L AU - Leonardson, Gary R AU - Borzelleca, Joseph AU - Welty, Thomas K AD - Aberdeen Area Indian Health Service, Aberdeen, SD, USA. kvig6@aol.com Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 760 EP - 765 VL - 12 IS - 6 SN - 1092-7875, 1092-7875 KW - Index Medicus KW - Odds Ratio KW - Humans KW - Midwestern United States -- epidemiology KW - Child, Preschool KW - Pregnancy KW - Indians, North American KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Female KW - Male KW - Prevalence KW - Family Relations KW - Alcoholism -- epidemiology KW - Intergenerational Relations KW - Fetal Alcohol Spectrum Disorders -- epidemiology KW - Alcoholism -- complications KW - Fetal Alcohol Spectrum Disorders -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69634019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maternal+and+child+health+journal&rft.atitle=Characteristics+of+grandmothers+who+have+grandchildren+with+fetal+alcohol+syndrome+or+incomplete+fetal+alcohol+syndrome.&rft.au=Kvigne%2C+Valborg+L%3BLeonardson%2C+Gary+R%3BBorzelleca%2C+Joseph%3BWelty%2C+Thomas+K&rft.aulast=Kvigne&rft.aufirst=Valborg&rft.date=2008-11-01&rft.volume=12&rft.issue=6&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=Maternal+and+child+health+journal&rft.issn=10927875&rft_id=info:doi/10.1007%2Fs10995-007-0308-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10995-007-0308-y ER - TY - JOUR T1 - Genomic analysis of polycyclic aromatic hydrocarbon degradation in Mycobacterium vanbaalenii PYR-1. AN - 69588576; 18421421 AB - Mycobacterium vanbaalenii PYR-1 is well known for its ability to degrade a wide range of high-molecular-weight (HMW) polycyclic aromatic hydrocarbons (PAHs). The genome of this bacterium has recently been sequenced, allowing us to gain insights into the molecular basis for the degradation of PAHs. The 6.5 Mb genome of PYR-1 contains 194 chromosomally encoded genes likely associated with degradation of aromatic compounds. The most distinctive feature of the genome is the presence of a 150 kb major catabolic region at positions 494 approximately 643 kb (region A), with an additional 31 kb region at positions 4,711 approximately 4,741 kb (region B), which is predicted to encode most enzymes for the degradation of PAHs. Region A has an atypical mosaic structure made of several gene clusters in which the genes for PAH degradation are complexly arranged and scattered around the clusters. Significant differences in the gene structure and organization as compared to other well-known aromatic hydrocarbon degraders including Pseudomonas and Burkholderia were revealed. Many identified genes were enriched with multiple paralogs showing a remarkable range of diversity, which could contribute to the wide variety of PAHs degraded by M. vanbaalenii PYR-1. The PYR-1 genome also revealed the presence of 28 genes involved in the TCA cycle. Based on the results, we proposed a pathway in which HMW PAHs are degraded into the beta-ketoadipate pathway through protocatechuate and then mineralized to CO2 via TCA cycle. We also identified 67 and 23 genes involved in PAH degradation and TCA cycle pathways, respectively, to be expressed as proteins. JF - Biodegradation AU - Kim, Seong-Jae AU - Kweon, Ohgew AU - Jones, Richard C AU - Edmondson, Ricky D AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 859 EP - 881 VL - 19 IS - 6 KW - Adipates KW - 0 KW - DNA Transposable Elements KW - Environmental Pollutants KW - Polycyclic Aromatic Hydrocarbons KW - 3-oxoadipic acid KW - 1379JRA56F KW - Index Medicus KW - Phylogeny KW - Genome, Bacterial KW - Adipates -- metabolism KW - Citric Acid Cycle -- genetics KW - Biodegradation, Environmental KW - Inactivation, Metabolic -- genetics KW - DNA Transposable Elements -- genetics KW - Models, Biological KW - Mycobacterium -- genetics KW - Environmental Pollutants -- metabolism KW - Mycobacterium -- metabolism KW - Polycyclic Aromatic Hydrocarbons -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69588576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biodegradation&rft.atitle=Genomic+analysis+of+polycyclic+aromatic+hydrocarbon+degradation+in+Mycobacterium+vanbaalenii+PYR-1.&rft.au=Kim%2C+Seong-Jae%3BKweon%2C+Ohgew%3BJones%2C+Richard+C%3BEdmondson%2C+Ricky+D%3BCerniglia%2C+Carl+E&rft.aulast=Kim&rft.aufirst=Seong-Jae&rft.date=2008-11-01&rft.volume=19&rft.issue=6&rft.spage=859&rft.isbn=&rft.btitle=&rft.title=Biodegradation&rft.issn=1572-9729&rft_id=info:doi/10.1007%2Fs10532-008-9189-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-14 N1 - Date created - 2008-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10532-008-9189-z ER - TY - JOUR T1 - Engineering case reports: evaluation of a local exhaust ventilation system for controlling exposures during liquid flavoring production. AN - 69513213; 18770075 JF - Journal of occupational and environmental hygiene AU - Old, Leo AU - Dunn, Kevin H AU - Garcia, Alberto AU - Echt, Alan AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - D103 EP - D110 VL - 5 IS - 11 KW - Flavoring Agents KW - 0 KW - Index Medicus KW - Occupational Exposure -- prevention & control KW - Flavoring Agents -- chemical synthesis KW - Food-Processing Industry KW - Ventilation -- instrumentation KW - Ventilation -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69513213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Engineering+case+reports%3A+evaluation+of+a+local+exhaust+ventilation+system+for+controlling+exposures+during+liquid+flavoring+production.&rft.au=Old%2C+Leo%3BDunn%2C+Kevin+H%3BGarcia%2C+Alberto%3BEcht%2C+Alan&rft.aulast=Old&rft.aufirst=Leo&rft.date=2008-11-01&rft.volume=102&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Basic+%26+clinical+pharmacology+%26+toxicology&rft.issn=1742-7843&rft_id=info:doi/10.1111%2Fj.1742-7843.2007.00184.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620802363274 ER - TY - JOUR T1 - Analytical performance criteria. Field evaluation of diacetyl sampling and analytical methods. AN - 69467589; 18726763 JF - Journal of occupational and environmental hygiene AU - Ashley, Kevin AU - McKernan, Lauralynn Taylor AU - Burroughs, Edward AU - Deddens, James AU - Pendergrass, Stephanie AU - Streicher, Robert P AD - National Institute for Occupational Safety and Health, Cincinnati,Ohio, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - D111 EP - D116 VL - 5 IS - 11 KW - Air Pollutants, Occupational KW - 0 KW - Acetoin KW - BG4D34CO2H KW - Diacetyl KW - K324J5K4HM KW - Index Medicus KW - United States KW - Humans KW - Humidity KW - National Institute for Occupational Safety and Health (U.S.) KW - Diacetyl -- analysis KW - Air Pollutants, Occupational -- analysis KW - Acetoin -- analysis KW - Environmental Monitoring -- standards KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69467589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Analytical+performance+criteria.+Field+evaluation+of+diacetyl+sampling+and+analytical+methods.&rft.au=Ashley%2C+Kevin%3BMcKernan%2C+Lauralynn+Taylor%3BBurroughs%2C+Edward%3BDeddens%2C+James%3BPendergrass%2C+Stephanie%3BStreicher%2C+Robert+P&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2008-11-01&rft.volume=5&rft.issue=3&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620802363282 ER - TY - JOUR T1 - Integration of viral hepatitis services into opioid treatment programs. AN - 66675932; 19192765 AB - Opioid treatment programs (OTPs) dispense methadone and buprenorphine under specific federal regulations to individuals diagnosed with opioid dependence. OTPs can provide a comprehensive therapeutic milieu, often including primary medical care, psychosocial counseling, vocational rehabilitation, ongoing performance monitoring, and other vital services. Because of the high prevalence of infectious diseases, particularly hepatitis C virus infection, model OTPs are developing comprehensive care and treatment programs that integrate general medical and infectious disease-related medical care with substance abuse and mental health services. Integrating hepatitis care services in the substance abuse treatment settings fosters access to care for patients with multiple comorbidities, many who otherwise would not receive needed care. Improving health related outcomes for this patient population with complex medical problems requires an advanced integrated model of care for OTPs that can be exemplified through establishing resources needed to prevent hepatitis infection as standard of care. Outcomes management becomes possible through enhancing current capability of existing dispensing programs. This may serve as a national model for highly cost-efficient healthcare that has a measurable outcome of improved health. JF - Journal of opioid management AU - Kresina, Thomas F AU - Bruce, R Douglas AU - Lubran, Robert AU - Clark, H Westley AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA. PY - 2008 SP - 369 EP - 381 VL - 4 IS - 6 SN - 1551-7489, 1551-7489 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - United States KW - Young Adult KW - Patient Education as Topic KW - Humans KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Methadone -- therapeutic use KW - Hepatitis, Viral, Human -- drug therapy KW - Substance Abuse Treatment Centers -- organization & administration KW - Opioid-Related Disorders -- complications KW - Hepatitis, Viral, Human -- complications KW - Narcotics -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Mental Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66675932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+opioid+management&rft.atitle=Integration+of+viral+hepatitis+services+into+opioid+treatment+programs.&rft.au=Kresina%2C+Thomas+F%3BBruce%2C+R+Douglas%3BLubran%2C+Robert%3BClark%2C+H+Westley&rft.aulast=Kresina&rft.aufirst=Thomas&rft.date=2008-11-01&rft.volume=4&rft.issue=6&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Journal+of+opioid+management&rft.issn=15517489&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-26 N1 - Date created - 2009-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational Racial Composition and Nonfatal Work Injuries AN - 59855779; 200906921 AB - Is there an association between occupational racial composition and nonfatal workplace injuries? Guided by several labor market theories (queuing, social closure, devaluation, poor market position, and human capital), we use occupational data from the U.S. Census and Dictionary of Occupational Titles combined with individual data from the National Longitudinal Survey of Youth to answer this question. Hierarchical generalized linear models of individuals within occupations show that there is an association between occupational racial composition and workplace injuries, but this association is only statistically significant for white men in the model controlling for relevant occupational and individual level characteristics. A 10 percent increase in the occupation percent black is associated with a 28 percent increase in injury risk. Contrary to expectations, white men have the highest adjusted odds of injury; white women and black men have significantly lower odds of injury than white men. Additionally, occupation-level environmental hazards and individual-level education, hours worked per week, jobs with insurance benefits, working in the South, and specific industries are associated with differential injury risk. These findings are consistent with labor market theories that suggest social closure, market position, and individual skills contribute to differential labor market outcomes. We demonstrate that sociological theories of labor market inequality are useful for understanding workplace injury risk, and that workplace injuries should be studied as an outcome of social inequality. Adapted from the source document. JF - Social Problems AU - Berdahl, Terceira A AU - McQuillan, Julia AD - Center for Financing, Access, and Cost Trends, Agency for Health Care Research and Quality, 540 Gaither Road, Suite 5000, Rockville, MD 20850 terceira.berdahl@ahrq.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 549 EP - 572 PB - The University of California Press, Berkeley CA VL - 55 IS - 4 SN - 0037-7791, 0037-7791 KW - occupational racial composition, work injury, health, labor markets, and social inequality KW - Injuries KW - Occupational Safety and Health KW - Social Inequality KW - Labor Market Segmentation KW - United States of America KW - Racial Differences KW - article KW - 9221: politics and society; politics and society UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59855779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Problems&rft.atitle=Occupational+Racial+Composition+and+Nonfatal+Work+Injuries&rft.au=Berdahl%2C+Terceira+A%3BMcQuillan%2C+Julia&rft.aulast=Berdahl&rft.aufirst=Terceira&rft.date=2008-11-01&rft.volume=55&rft.issue=4&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=Social+Problems&rft.issn=00377791&rft_id=info:doi/10.1525%2Fsp.2008.55.4.549 LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2009-03-03 N1 - Number of references - 51 N1 - Last updated - 2016-09-28 N1 - CODEN - SOPRAG N1 - SubjectsTermNotLitGenreText - Occupational Safety and Health; Racial Differences; Injuries; Labor Market Segmentation; Social Inequality; United States of America DO - http://dx.doi.org/10.1525/sp.2008.55.4.549 ER - TY - JOUR T1 - Quality Assurance and Improvement Practice in Mental Health Agencies: Roles, Activities, Targets and Contributions AN - 57282865; 200904353 AB - Accompanying the rise in the number of mental health agency personnel tasked with quality assurance and improvement (QA/I) responsibilities is an increased need to understand the nature of the work these professionals undertake. Four aspects of the work of quality assurance and improvement (QA/I) professionals in mental health were explored in this qualitative study: their perceived roles, their major activities, their QA/I targets, and their contributions. In-person interviews were conducted with QA/I professionals at 16 mental health agencies. Respondents perceived their roles at varying levels of complexity, focused on different targets, and used different methods to conduct their work. Few targets of QA/I work served as indicators of high quality care. Most QA/I professionals provided concrete descriptions of how they had improved agency services, while others could describe none. Accreditation framed much of agency QA/I work, perhaps to its detriment. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - McMillen, Curtis AU - Zayas, Luis E AU - Books, Samantha AU - Lee, Madeline AD - Center for Mental Health Services Research George Warren Brown School of Social Work, Washington University in St. Louis, Washington University Campus Box 1196, One Brookings Drive, St. Louis, MO 63130, USA Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 458 EP - 467 PB - Springer, Dordrecht The Netherlands VL - 35 IS - 6 SN - 0894-587X, 0894-587X KW - Quality of care KW - Quality assurance KW - Mental health professionals KW - Mental health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57282865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Quality+Assurance+and+Improvement+Practice+in+Mental+Health+Agencies%3A+Roles%2C+Activities%2C+Targets+and+Contributions&rft.au=McMillen%2C+Curtis%3BZayas%2C+Luis+E%3BBooks%2C+Samantha%3BLee%2C+Madeline&rft.aulast=McMillen&rft.aufirst=Curtis&rft.date=2008-11-01&rft.volume=35&rft.issue=6&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-008-0189-4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Mental health; Quality assurance; Quality of care; Mental health professionals DO - http://dx.doi.org/10.1007/s10488-008-0189-4 ER - TY - JOUR T1 - Signal-Averaged Electrocardiogram in Physically Healthy, Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Users AN - 57277808; 200903991 AB - Objectives: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) use has been associated with cardiac arrhythmias. Markers of ventricular late potentials (VLP), which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG), but not by standard ECG. Methods: We evaluated SA-ECG parameters in 21 physically healthy, recently abstinent MDMA users who also used cannabis (11 males, mean [SD] age 23.3 [4.6] years, 2.8 [2.0] years of use), 18 physically healthy cannabis users (8 males, mean [SD] age 26.6 [7.1] years, 11.2 [5.4] years of use) and 54 non-drug-using controls (21 males, mean [SD] age 28.4 [7.8] years). We analyzed three SA-ECG parameters considered markers of VLPs: duration of filtered QRS complex (fQRS), duration of low amplitude potentials during terminal 40 ms of QRS complex (LAS40), and root mean square voltage during terminal 40 ms of QRS complex (RMS40). Results: MDMA users, cannabis users, and non-drug-using controls did not differ significantly from each other in fQRS, LAS40, or RMS40 values or in the proportion of subjects with abnormal SA-ECG parameters. There were significant gender differences among controls, but not among MDMA users. Conclusion: These findings suggest that chronic MDMA use is neither quantitatively nor qualitatively associated with a high prevalence of abnormal SA-ECG parameters indicative of VLP markers. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Kanneganti, Praveen AU - Huestis, Marilyn A AU - Kolbrich, Erin A AU - Goodwin, Robert AU - Ziegelstein, Roy C AU - Gorelick, David A AD - Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 712 EP - 720 PB - Taylor & Francis Inc., Philadelphia, PA VL - 34 IS - 6 SN - 0095-2990, 0095-2990 KW - Heart arrhythmia KW - Ecstasy drug KW - Echocardiography KW - Cannabis KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57277808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Signal-Averaged+Electrocardiogram+in+Physically+Healthy%2C+Chronic+3%2C4-Methylenedioxymethamphetamine+%28MDMA%29+Users&rft.au=Kanneganti%2C+Praveen%3BHuestis%2C+Marilyn+A%3BKolbrich%2C+Erin+A%3BGoodwin%2C+Robert%3BZiegelstein%2C+Roy+C%3BGorelick%2C+David+A&rft.aulast=Kanneganti&rft.aufirst=Praveen&rft.date=2008-11-01&rft.volume=34&rft.issue=6&rft.spage=712&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.1080%2F00952990802308254 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Ecstasy drug; Cannabis; Echocardiography; Heart arrhythmia DO - http://dx.doi.org/10.1080/00952990802308254 ER - TY - JOUR T1 - Go out or stay in? The effects of zero tolerance laws on alcohol use and drinking and driving patterns among college students AN - 57273080; 200902002 AB - Zero tolerance laws make it illegal per se for anyone under age 21 to drive with any measurable amount of blood alcohol. Although a link has been established between zero tolerance laws and lower motor vehicle fatalities, research has not produced strong evidence on how zero tolerance laws influence individual alcohol use and drinking and driving behaviors. Using a unique data set and a difference-in-difference-in-difference-type research design, we are able to analyze a number of pathways through which zero tolerance laws can work among an important underage population, college students. We find that zero tolerance laws reduce drinking and driving among college students. Further analysis of our detailed alcohol use measures suggests that zero tolerance laws are particularly effective at reducing the probability of driving after drinking for those who reported drinking away from home. [Copyright 2008 John Wiley and Sons, Ltd.] JF - Health Economics AU - Liang, Lan AU - Huang, Jidong AD - Agency for Healthcare Research and Quality, USA lliang@ahrq.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1261 EP - 1275 PB - John Wiley, Chichester UK VL - 17 IS - 11 SN - 1057-9230, 1057-9230 KW - Alcohol consumption KW - Underage KW - Driving KW - Zero tolerance KW - Legislation KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57273080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Go+out+or+stay+in%3F+The+effects+of+zero+tolerance+laws+on+alcohol+use+and+drinking+and+driving+patterns+among+college+students&rft.au=Liang%2C+Lan%3BHuang%2C+Jidong&rft.aulast=Liang&rft.aufirst=Lan&rft.date=2008-11-01&rft.volume=17&rft.issue=11&rft.spage=1261&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1321 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Zero tolerance; Driving; Undergraduate students; Alcohol consumption; Legislation; Underage DO - http://dx.doi.org/10.1002/hec.1321 ER - TY - JOUR T1 - Healthy Start: Lessons Learned on Interconception Care AN - 57250304; 200905455 AB - The Federal Healthy Start program was started in 1991 to address the factors that contribute to the Nation's high infant mortality rate, particularly among populations with disproportionately high rates of adverse perinatal health outcomes. The goals of Healthy Start are to reduce disparities in access to and utilization of health services by using a lifespan approach, improving the local health care system, and increasing consumer and community input into health care decisions. In 2007, Healthy Start served 99 communities in 38 states, the District of Columbia, and Puerto Rico. Most Healthy Start grantees are nonprofit organizations. Since 2005, all 97 Healthy Start grantees (and the 2 additional grantees funded in 2007) have been required to include an interconception care component. Three quarters of grantees enrolled the majority of their interconception clients during the prenatal period. Most grantees used care coordination and case management as the primary approach to improving interconception health care. In 2007, 93 interconception projects reported that 9 out of 10 women had an ongoing source of primary care. Grantees screened to detect health conditions and risks, as well as provided an opportunity to provide vital information to women about their risks for chronic conditions such as obesity, hypertension, and diabetes. The Healthy Start interconception components demonstrate a critical need for and the potential impact of a strong interconception care program for high-risk populations such as women living in poverty, in medically underserved communities, and without health coverage. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Badura, Maribeth AU - Johnson, Kay AU - Hench, Karen AU - Reyes, Madelyn AD - U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, Division of Healthy Start and Perinatal Services, Rockville, Maryland mbadura@hrsa.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - S61 EP - S66 PB - Elsevier Science, New York NY VL - 18 IS - 6S1 SN - 1049-3867, 1049-3867 KW - Case management KW - Coverage KW - Health care KW - Life span KW - Perinatal KW - Women KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Healthy+Start%3A+Lessons+Learned+on+Interconception+Care&rft.au=Badura%2C+Maribeth%3BJohnson%2C+Kay%3BHench%2C+Karen%3BReyes%2C+Madelyn&rft.aulast=Badura&rft.aufirst=Maribeth&rft.date=2008-11-01&rft.volume=18&rft.issue=6S1&rft.spage=S61&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2008.07.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Health care; Perinatal; Case management; Coverage; Life span DO - http://dx.doi.org/10.1016/j.whi.2008.07.010 ER - TY - JOUR T1 - Mycobacterium bovis BCG Immunization Induces Protective Immunity against Nine Different Mycobacterium tuberculosis Strains in Mice , AN - 21498808; 12495231 AB - Recent preclinical and epidemiologic studies have suggested that certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity. To investigate the strain specificity of BCG-induced protective responses in a murine model of pulmonary tuberculosis, C57BL/6 mice were vaccinated with BCG vaccine and then challenged 2 months later with one of nine M. tuberculosis isolates. Four of these strains were from the W-Beijing lineage (HN878, N4, NHN5, and ChS) while four were non-Beijing-type isolates (C913, CDC1551, NY669, and NY920). As a control, the WHO standard M. tuberculosis Erdman strain was evaluated in these vaccination/challenge experiments. To assess the protective responses evoked by BCG immunization, organ bacterial burdens and lung pathology were assessed in vaccinated and naive mice at 4, 12, and 20 weeks postchallenge as well as during the day of infection. At 4 weeks after the aerosol challenge with each of these strains, significantly reduced bacterial growth in the lungs and spleens and significantly improved lung pathology were seen in all vaccinated animals compared to naive controls. After 12 weeks, reduced organ bacterial burdens were detected in vaccinated animals infected with six of nine challenge strains. Although lung CFU values were lower in vaccinated mice for only three of nine groups at 20 weeks postchallenge, significantly decreased lung inflammation was seen in all immunized animals relative to controls at 20 weeks postchallenge. Taken together, these data demonstrate that BCG vaccination protects against infection with diverse M. tuberculosis strains in the mouse model of pulmonary tuberculosis and suggest that strain-specific resistance to BCG-induced protective immunity may be uncommon. JF - Infection and Immunity AU - Jeon, Bo Young AU - Derrick, Steven C AU - Lim, JaeHyun AU - Kolibab, Kristopher AU - Dheenadhayalan, Veerabadran AU - Yang, Amy Li AU - Kreiswirth, Barry AU - Morris, Sheldon L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland, sheldon.morris@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 5173 EP - 5180 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 11 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Aerosols KW - Data processing KW - Animal models KW - Spleen KW - Mycobacterium bovis KW - Immunity KW - Genotypes KW - Infection KW - Vaccination KW - Inflammation KW - BCG KW - Lung KW - Colony-forming cells KW - Tuberculosis KW - Vaccines KW - Mycobacterium tuberculosis KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21498808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Mycobacterium+bovis+BCG+Immunization+Induces+Protective+Immunity+against+Nine+Different+Mycobacterium+tuberculosis+Strains+in+Mice+%2C&rft.au=Jeon%2C+Bo+Young%3BDerrick%2C+Steven+C%3BLim%2C+JaeHyun%3BKolibab%2C+Kristopher%3BDheenadhayalan%2C+Veerabadran%3BYang%2C+Amy+Li%3BKreiswirth%2C+Barry%3BMorris%2C+Sheldon+L&rft.aulast=Jeon&rft.aufirst=Bo&rft.date=2008-11-01&rft.volume=76&rft.issue=11&rft.spage=5173&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00019-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Aerosols; Data processing; Animal models; Spleen; Genotypes; Immunity; Infection; Vaccination; Inflammation; Lung; BCG; Colony-forming cells; Tuberculosis; Vaccines; Mycobacterium bovis; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/IAI.00019-08 ER - TY - JOUR T1 - Effects of Thrombosed Vena Cava Filters on Blood Flow: Flow Visualization and Numerical Modeling AN - 21296463; 11901420 AB - Inferior vena cava (IVC) filters are used to prevent pulmonary embolism (PE) in patients with deep vein thrombosis for whom anticoagulation is contraindicated. IVC filters have been shown to be effective in trapping embolized clots and preventing PE; however, among the commercially available designs, the optimal balance of clot capture efficiency, clot dissolution, and prevention of to vena cava occlusion is unknown. Clot capture efficiency has been quantified in numerous invitro studies, in which model clots are released into a mock circulation system, with the relative capture efficiency of various IVC filters analyzed statistically. In general, two-stage filters have been found to be more efficient than one-stage filters. However, other factors may play a role in the ultimate dissolution of clots and in the overall effect of the resulting blood flow on caval vasculature. Clot dissolution has been shown to increase with increasing wall shear stress, while low and oscillating wall shear stresses are known to have a deleterious effect on vessel walls, causing intimal hyperplasia. This paper describes the effect of IVC filters on blood flow, velocity patterns, and wall shear stress by flow visualization and computational fluid dynamics. JF - Annals of Biomedical Engineering AU - Stewart, Sandy FC AU - Robinson, Ronald A AU - Nelson, Robert A AU - Malinauskas, Richard A AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, White Oak Bldg 62, Rm 2210, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA, sandy.stewart@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1764 EP - 1781 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 36 IS - 11 SN - 0090-6964, 0090-6964 KW - Biotechnology and Bioengineering Abstracts KW - Statistical analysis KW - Computer applications KW - Trapping KW - Thrombosis KW - Mechanical stimuli KW - Filters KW - Hyperplasia KW - Veins KW - Lung KW - Embolism KW - Occlusion KW - Dissolution KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21296463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=Effects+of+Thrombosed+Vena+Cava+Filters+on+Blood+Flow%3A+Flow+Visualization+and+Numerical+Modeling&rft.au=Stewart%2C+Sandy+FC%3BRobinson%2C+Ronald+A%3BNelson%2C+Robert+A%3BMalinauskas%2C+Richard+A&rft.aulast=Stewart&rft.aufirst=Sandy&rft.date=2008-11-01&rft.volume=36&rft.issue=11&rft.spage=1764&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1007%2Fs10439-008-9560-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Filters; Mechanical stimuli; Dissolution; Hyperplasia; Embolism; Occlusion; Statistical analysis; Trapping; Thrombosis; Veins; Computer applications; Lung DO - http://dx.doi.org/10.1007/s10439-008-9560-6 ER - TY - RPRT T1 - Key Design Factors of Enclosed Cab Dust Filtration Systems AN - 20773942; 10308235 AB - Enclosed cabs are a primary means of reducing the silica dust exposure of equipment operators at surface mines. The National Institute for Occupational Safety and Health experimentally investigated various factor effects on cab air filtration system performance. The factors investigated were intake filter efficiency, intake air leakage, intake filter loading (filter flow resistance), recirculation filter use, and wind effects on cab particulate penetration. Adding an intake pressurizer fan to the filtration system was also investigated. Results indicate that intake filter efficiency and recirculation filter use were the two most influential factors on cab penetration performance. Use of the recirculation filter reduced cab penetration by usually an order of magnitude over the intake air filter alone because of the multiplicative filtration of the cab interior air. Intake air leakage and filter loading affected the cab penetration to a lesser extent, while wind had the least impact on cab penetration between the calm and 10-mph wind velocities tested. Adding an intake pressurizer fan notably increased intake airflow and cab pressure with only minor changes to cab penetration. A mathematical model was developed that describes cab penetration in terms of intake filter efficiency, intake air quantity, intake air leakage, recirculation filter efficiency, recirculation filter quantity, and wind penetration. JF - Key Design Factors of Enclosed Cab Dust Filtration Systems. 51 pp. Nov 2008. AU - Organiscak, JA AU - Cecala, AB Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 51 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Occupational safety KW - Particulates KW - Dust KW - air flow KW - silica KW - Air flow KW - Pollutant removal KW - Mathematical models KW - Leakage KW - Velocity KW - Mines KW - Design KW - Filtration KW - Air purification KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20773942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Organiscak%2C+JA%3BCecala%2C+AB&rft.aulast=Organiscak&rft.aufirst=JA&rft.date=2008-11-01&rft.volume=&rft.issue=&rft.spage=51&rft.isbn=&rft.btitle=Key+Design+Factors+of+Enclosed+Cab+Dust+Filtration+Systems&rft.title=Key+Design+Factors+of+Enclosed+Cab+Dust+Filtration+Systems&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Lactobacillus-mediated inhibition of clinical toxic shock syndrome Staphylococcus aureus strains and its relation to acid and peroxide production AN - 20532896; 9213695 AB - The inhibitory activities of 39 strains representing 20 different species of Lactobacillus toward a menstrual toxic shock syndrome (TSS) Staphylococcus aureus archetype strain MN8 were investigated. Nearly every strain (38 of 39) produced an inhibitory effect under both aerobic and anaerobic conditions when assayed on agar medium. In addition, the MN8 inhibition was conserved against at least 10 other clinical TSS S. aureus isolates and, interestingly, required actively growing cultures of Lactobacillus (verified with a two-well co-culture system in broth medium). This general uniform inhibition could be ameliorated by organic buffer (PIPES) supplied in the growth medium and, with only one exception, MRS medium adjusted with non-organic acid (HCl) failed to support growth of TSS strains at or below pH 5.5. By comparison, the vast majority of lactobacilli in this study decreased culture pH to a range of 4-5. Hydrogen peroxide production by the lactobacilli was also assessed and verified by two different methodologies revealing a broad spectrum of phenotypes that, contrary to reports touting its effectiveness, did not seem to correspond with our inhibition studies. Furthermore, resistances to peroxide by MN8, other TSS strains, and a subset of lactobacilli used in this study were nearly identical whereas the S. aureus collection was slightly more sensitive to racemic lactic acid than the lactobacilli. Collectively, these data suggest that the underlying inhibition toward Staphylococcus is generally conserved in Lactobacillus sp. and is related to a common factor in this genus involving promotion of acidic conditions. JF - Anaerobe AU - Elklns, CA AU - Munoz, ME AU - Mullis, L B AU - Stingley, R L AU - Hart, ME AD - Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Drive, Jefferson, AR 72079-9502, USA Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 261 EP - 267 VL - 14 IS - 5 SN - 1075-9964, 1075-9964 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Agar KW - Lactobacillus KW - Data processing KW - Hydrogen peroxide KW - Lactic acid KW - Menstruation KW - Staphylococcus aureus KW - Anaerobic conditions KW - pH effects KW - Toxic shock syndrome KW - J 02320:Cell Biology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20532896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Lactobacillus-mediated+inhibition+of+clinical+toxic+shock+syndrome+Staphylococcus+aureus+strains+and+its+relation+to+acid+and+peroxide+production&rft.au=Elklns%2C+CA%3BMunoz%2C+ME%3BMullis%2C+L+B%3BStingley%2C+R+L%3BHart%2C+ME&rft.aulast=Elklns&rft.aufirst=CA&rft.date=2008-11-01&rft.volume=14&rft.issue=5&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2008.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Agar; Data processing; Hydrogen peroxide; Lactic acid; Menstruation; Anaerobic conditions; pH effects; Toxic shock syndrome; Lactobacillus; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.anaerobe.2008.08.003 ER - TY - JOUR T1 - A Review of Work Schedule Issues and Musculoskeletal Disorders with an Emphasis on the Healthcare Sector AN - 20350399; 9024605 AB - Musculoskeletal disorders (MSDs) are a significant cause of morbidity in healthcare workers. The influence of shift work and long work hours on risk for MSDs is an area that needs further exploration. The purpose of this report is to assess research progress and gaps across studies that examined the relationship between demanding work schedules and MSD outcomes. A literature search identified 23 peer-reviewed publications in the English language that examined MSDs and long work hours, shift work, extended work shifts, mandatory overtime, or weekend work. Eight studies that examined long work hours and had some controls for physical job demands reported a significant increase in one or more measures of MSDs. Fourteen studies examining shift work had incomparable methods and types of shift work, and therefore, no clear trends in findings were identified. A small number of studies examined mandatory overtime, work on weekends and days off, and less than 10 h off between shifts. Given the complexity of the work schedule research topic, relatively few studies have adequately examined the relationship of work schedules and musculoskeletal outcomes. The review discusses research gaps including methodological issues and suggests research priorities. JF - Industrial Health AU - Caruso, C C AU - Waters, T R AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), Division of Applied Research and Technology, 4676 Columbia Parkway MS C-24, Cincinnati, OH 45226-1998, USA Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 523 EP - 534 VL - 46 IS - 6 SN - 0019-8366, 0019-8366 KW - Risk Abstracts; Health & Safety Science Abstracts KW - shift work KW - Health care KW - Reviews KW - working conditions KW - musculoskeletal system KW - Medical personnel KW - Morbidity KW - Occupational health KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20350399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=A+Review+of+Work+Schedule+Issues+and+Musculoskeletal+Disorders+with+an+Emphasis+on+the+Healthcare+Sector&rft.au=Caruso%2C+C+C%3BWaters%2C+T+R&rft.aulast=Caruso&rft.aufirst=C&rft.date=2008-11-01&rft.volume=46&rft.issue=6&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - shift work; Health care; Reviews; Morbidity; Medical personnel; musculoskeletal system; working conditions; Occupational health ER - TY - JOUR T1 - Deaths Due to Bloodborne Infections and Their Sequelae Among Health-Care Workers AN - 20251934; 8891720 AB - Background The odds of dying from bloodborne infections among health-care workers has not been well studied. Methods Using data from the National Occupational Mortality Surveillance (NOMS) system, a matched case-control design was employed to examine the relationship between health-care employment and death from HIV, hepatitis B (HBV), hepatitis C (HCV; non-A/non-B viral hepatitis), liver cancer, and cirrhosis from 1984 to 2004. We examined the whole health-care industry and specific health-care occupations. Results From 1984 to 2004, NOMS captured 248,550 deaths from bloodborne pathogens and their sequelae. Employment in the health-care industry was associated with increased risk of death from HIV (MOR=2.27; 95% confidence interval [CI]=2.11-2.44), HBV (MOR=1.98; CI=1.58-2.48), and cirrhosis (MOR=1.09; CI=1.04-1.15) among males, and death from HCV among both males (MOR=1.46; CI=1.22-1.75) and females (MOR=1.22; CI=1.05-1.40). Nursing was the occupation with the highest MORs among males for HIV and HBV, but female nurses were at decreased risk of dying from HIV (MOR=0.69; CI=0.57-0.83). Conclusions Employment in the health-care industry was found to be associated with deaths from several bloodborne pathogens and their sequelae among males, but only with HCV among females from 1984 to 2004 in this exploratory study. Am. J. Ind. Med. 51:812-824, 2008. Published 2008 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Luckhaupt, Sara E AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, sluckhaupt@cdc.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 812 EP - 824 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 51 IS - 11 SN - 0271-3586, 0271-3586 KW - Virology & AIDS Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - employment KW - Liver cancer KW - hepatitis B KW - Infection KW - Medical personnel KW - Workers KW - Nursing KW - infection KW - Hepatitis B KW - Hepatitis C KW - Mortality KW - Cirrhosis KW - Data processing KW - Hepatitis B virus KW - Complications KW - Pathogens KW - Cancer KW - Hepatitis KW - Hepatitis C virus KW - Human immunodeficiency virus KW - Liver KW - nursing KW - R2 23080:Industrial and labor KW - V 22360:AIDS and HIV KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20251934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Deaths+Due+to+Bloodborne+Infections+and+Their+Sequelae+Among+Health-Care+Workers&rft.au=Luckhaupt%2C+Sara+E%3BCalvert%2C+Geoffrey+M&rft.aulast=Luckhaupt&rft.aufirst=Sara&rft.date=2008-11-01&rft.volume=51&rft.issue=11&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20610 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Workers; Data processing; Cirrhosis; Complications; Liver cancer; Nursing; Hepatitis B; Hepatitis C; Pathogens; Infection; Hepatitis; employment; Human immunodeficiency virus; Liver; infection; hepatitis B; nursing; Medical personnel; Cancer; Hepatitis C virus; Hepatitis B virus DO - http://dx.doi.org/10.1002/ajim.20610 ER - TY - JOUR T1 - Determination of orhto-phthalaldehyde in air and on surfaces AN - 20239029; 8852894 AB - Three sampling and analytical methods have been developed and evaluated for ortho-phthalaldehyde (OPA): (1) an HPLC-UV method for OPA in air, (2) a fluorimetric method for OPA on surfaces, and (3) a colorimetric method for OPA on surfaces. (1) The air sampler contains 350 mg of silica gel coated with 1 mg of acidified 2,4-dinitrophenylhydrazine (DNPH). Air sampling may be conducted at 0.03 to 1.0 L min super(-1) for periods up to 8 h. Samples were eluted with ethyl acetate, and the eluents were allowed to stand for 72 h. Analysis was by high performance liquid chromatography (HPLC) with a UV detector set at 369 nm. An unusual phenomenon was the observation that the stability of the sample on a sampler at 3 degree C tends to decrease as the total quantity of OPA collected on the sampler decreases. Elution of the samples within 24 h of air sampling is required. The detection limit (LOD) is approximately 0.02 mu g of OPA per sample. OPA on surfaces may be collected with strips cut from a sheet of polyvinyl alcohol (PVA wipe). (2) In the surface wipe method with analysis by fluorescence measurement, the strips of PVA wipe were placed into dimethyl sulfoxide. An aliquot was treated with aqueous N-acetyl-L-cysteine and ethylenediamine. Analysis was performed with a portable fluorometer (excitation and emission wavelengths = 365 nm and 438 nm, respectively). The LOD is 0.2 mu g per sample. (3) In the surface wipe method with visual colorimetric detection, the strips of PVA wipe were placed into 30: 70 acetonitrile: water. An aliquot was treated with N-(1-naphthyl)ethylenediamine in 0.1 m sulfuric acid. After color development, the LOD is approximately 48 mu g per sample. These methods have been field tested in a hospital. JF - Journal of Environmental Monitoring AU - Tucker, S P AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA, sptl@cdc.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1337 EP - 1349 VL - 10 IS - 11 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Environment Abstracts KW - Alcohol KW - Fluorescence KW - Liquid chromatography KW - Air sampling KW - Sulfuric acid KW - Emissions KW - Acidification KW - checked KW - Hospitals KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20239029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Determination+of+orhto-phthalaldehyde+in+air+and+on+surfaces&rft.au=Tucker%2C+S+P&rft.aulast=Tucker&rft.aufirst=S&rft.date=2008-11-01&rft.volume=10&rft.issue=11&rft.spage=1337&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb809790a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Alcohol; Fluorescence; Liquid chromatography; Emissions; Sulfuric acid; Air sampling; Acidification; checked; Hospitals DO - http://dx.doi.org/10.1039/b809790a ER - TY - RPRT T1 - Explosion Effects on Mine Ventilation Stoppings AN - 20153640; 10308234 AB - The National Institute for Occupational Safety and Health (NIOSH) and the Mine Safety and Health Administration (MSHA) conducted joint research to evaluate explosion blast effects on typical U.S. mine ventilation stoppings in the Pittsburgh Research Laboratory (PRL) Lake Lynn Experimental Mine (LLEM). An innovative Australian-designed brattice stopping was also evaluated. After mine explosion accidents, MSHA conducts investigations to determine the cause(s) as a means to prevent future occurrences. As part of these postexplosion investigations, the condition of underground stoppings, including the debris from damaged stoppings, is documented as evidence of the approximate strength and the direction of the explosion forces. The LLEM data showed that a typical dry-stacked and coated solid-concrete-block stopping survived a total explosion pressure of similar to 6.7 psi ( similar to 46 kPa) and was destroyed at a total explosion pressure of similar to 7.6 psi ( similar to 52 kPa). In comparison, a typical dry-stacked and coated hollow-core concrete block stopping survived a total explosion pressure of similar to 3.4-4.3 psi ( similar to 23-30 kPa) and was destroyed at a total explosion pressure of similar to 3.6-5.2 psi ( similar to 25-36 kPa), depending on the length of the pressure pulse and the value of the pressure-time integral. A typical steel panel stopping design survived a total explosion pressure of 0.8 psi (5.5 kPa) and failed at a total explosion pressure of 1.3 psi (9 kPa). The LLEM data also showed that an obstacle blocking the path of a pressure wave resulted in a higher reflected pressure at the obstacle. An 8-in (20-cm) thick wet-laid solid concrete-block stopping coated on one side survived a total explosion pressure of similar to 26 psi ( similar to 180 kPa); this stopping was not tested to failure. A 6-in (15-cm) thick wet-laid solid-concrete block stopping coated on one side survived a total explosion pressure of similar to 14 psi ( similar to 97 kPa) and was destroyed at a total explosion pressure of similar to 25 psi ( similar to 172 kPa). An innovative Australian woven cloth stopping survived an explosion pressure of 4.0 psi (27 kPa) and was destroyed at an explosion pressure of similar to 6.1 psi ( similar to 42 kPa). These results will help investigators determine the approximate explosion forces that destroy or damage stoppings during actual coal mine explosions. JF - Explosion Effects on Mine Ventilation Stoppings. [np]. Nov 2008. AU - Weiss, E S AU - Cashdollar, K L AU - Harteis, S P AU - Shemon, G J AU - Beiter, DA AU - Urosek, JE Y1 - 2008/11// PY - 2008 DA - Nov 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Safety regulations KW - Ventilation KW - Occupational safety KW - Coal KW - Concrete KW - Accidents KW - Lakes KW - Australia KW - Steel KW - Laboratory testing KW - Mines KW - Explosions KW - USA KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20153640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Weiss%2C+E+S%3BCashdollar%2C+K+L%3BHarteis%2C+S+P%3BShemon%2C+G+J%3BBeiter%2C+DA%3BUrosek%2C+JE&rft.aulast=Weiss&rft.aufirst=E&rft.date=2008-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Explosion+Effects+on+Mine+Ventilation+Stoppings&rft.title=Explosion+Effects+on+Mine+Ventilation+Stoppings&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Fire Fighter Fatality Investigation and Prevention Program: Leading Recommendations for Preventing Fire Fighter Fatalities, 1998-2005 AN - 20144915; 10308233 AB - This document is a synthesis of the 1,286 individual recommendations from the 335 FFFIPP investigations conducted from 1998 to 2005. We hope that the fire service will use this document as a resource and catalyst for developing, updating, and implementing effective policies, programs, and training to prevent fatalities among fire fighters. JF - Fire Fighter Fatality Investigation and Prevention Program: Leading Recommendations for Preventing Fire Fighter Fatalities, 1998-2005. [np]. Nov 2008. AU - Anonymous Y1 - 2008/11// PY - 2008 DA - Nov 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - Fires KW - Training KW - prevention KW - Catalysts KW - H 7000:Fire Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20144915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Fire+Fighter+Fatality+Investigation+and+Prevention+Program%3A+Leading+Recommendations+for+Preventing+Fire+Fighter+Fatalities%2C+1998-2005&rft.title=Fire+Fighter+Fatality+Investigation+and+Prevention+Program%3A+Leading+Recommendations+for+Preventing+Fire+Fighter+Fatalities%2C+1998-2005&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - A Performance Evaluation of Two Overhead Power Line Proximity Warning Devices AN - 20144337; 10308236 AB - Accidental contact of overhead electrical power lines by mobile equipment is a leading cause of occupational fatalities in the United States, accounting for 20% of on-the-job electrocutions. Overhead electrical power line proximity warning devices (PWDs) are intended to warn personnel if mobile equipment moves within some preselected minimum distance of an energized overhead electrical power line. Two commercially available PWDs were tested at the National Institute for Occupational Safety and Healths (NIOSH) Pittsburgh Research Laboratory (PRL). The objective of the tests was to document performance capabilities and limitations for these PWDs by identifying factors that can influence their operation. The two PWDs evaluated in this research are the SIGALARM Model 210 marketed by Allied Safety Systems, LLC, and the ASE Model 2100 from Allied Safety Engineering. Both of these devices operate by measuring the electric field present around energized power lines. The PWDs were installed on a government-owned 22-st (20-mt) rough terrain crane. A purpose-built test site used for this research at PRL allowed operation of the crane near a variety of power line configurations operating at up to 25 kV. Test results show that several factors can adversely affect PWD performance. PWD alarm accuracy generally deteriorated when operating with a boom position significantly different than that used for the last sensitivity adjustment of the device. Another factor that can affect PWD performance is configuration of the overhead power line(s) involved. Accuracy of alarm activation distances was best for simple single-circuit installations, but degraded for multiple circuits on the same poles. This degradation was slightly greater for installations with different voltage levels and/or a combination of vertical and horizontal conductor arrangements. Performance also degraded for crane operation between two intersecting power line installations, especially for intersecting lines at different voltages. An additional aspect of power line configuration shown to influence PWD accuracy was phase sequence on the power line circuit(s). Specific phase conductor arrangements and combinations, particularly in multiple circuit installations, resulted in either improved or degraded accuracy. JF - A Performance Evaluation of Two Overhead Power Line Proximity Warning Devices. [np]. Nov 2008. AU - Homce, G T AU - Cawley, J C AU - Yenchek, M R Y1 - 2008/11// PY - 2008 DA - Nov 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Risk Abstracts; Health & Safety Science Abstracts KW - safety systems KW - Degradation KW - Occupational safety KW - Electric fields KW - Mortality KW - Sensitivity KW - USA KW - safety engineering KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20144337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Homce%2C+G+T%3BCawley%2C+J+C%3BYenchek%2C+M+R&rft.aulast=Homce&rft.aufirst=G&rft.date=2008-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Performance+Evaluation+of+Two+Overhead+Power+Line+Proximity+Warning+Devices&rft.title=A+Performance+Evaluation+of+Two+Overhead+Power+Line+Proximity+Warning+Devices&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Enhanced Microscopic Definition of Campylobacter jejuni 81-176 Adherence to, Invasion of, Translocation across, and Exocytosis from Polarized Human Intestinal Caco-2 Cells AN - 19686341; 8595848 AB - Campylobacter jejuni-mediated pathogenesis involves gut adherence and translocation across intestinal cells. The current study was undertaken to examine the C. jejuni interaction with and translocation across differentiated Caco-2 cells to better understand Campylobacter's pathogenesis. The efficiency of C. jejuni 81-176 invasion of Caco-2 cells was two- to threefold less than the efficiency of invasion of INT407 cells. Adherence-invasion analyses indicated that C. jejuni 81-176 adhered to most INT407 cells but invaded only about two-thirds of the host cells over 2 h (two bacteria/cell). In contrast, only 11 to 17% of differentiated Caco-2 cells were observed to bind and internalize either C. jejuni strain 81-176 or NCTC 11168, and a small percentage of infected Caco-2 cells contained 5 to 20 internalized bacteria per cell after 2 h. Electron microscopy revealed that individual C. jejuni cells adhered to the tips of host cell microvilli via intimate flagellar contacts and by lateral bacterial binding to the sides of microvilli. Next, bacteria were observed to bind at the apical host membrane surface via presumed interactions at one pole of the bacterium and with host membrane protrusions located near intercellular junctions. The latter contacts apparently resulted in coordinated, localized plasma membrane invagination, causing simultaneous internalization of bacteria into an endosome. Passage of this Campylobacter endosome intracellularly from the apical surface to the basolateral surface occurred over time, and bacterial release apparently resulted from endosome-basolateral membrane fusion (i.e., exocytosis). Bacteria were found intercellularly below tight junctions at 60 min postinfection, but not at earlier times. This study revealed unique host cell adherence contacts, early endocytosis-specific structures, and a presumptive exocytosis component of the transcellular transcytosis route. JF - Infection and Immunity AU - Hu, Lan AU - Tall, Ben D AU - Curtis, Sherill K AU - Kopecko, Dennis J AD - Laboratory of Enteric and Sexually Transmitted Diseases, FDA Center for Biologics Evaluation and Research, 29 Lincoln Drive, NIH Campus, Bldg. 29/420, Bethesda, Maryland 20892. FDA Center for Food Safety and Applied Nutrition, Laurel, Maryland 20708 Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 5294 EP - 5304 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 11 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Tight junctions KW - Membrane fusion KW - Exocytosis KW - Invaginations KW - endosomes KW - Digestive tract KW - Plasma membranes KW - Campylobacter jejuni KW - Intestine KW - Translocation KW - Electron microscopy KW - Flagella KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19686341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Enhanced+Microscopic+Definition+of+Campylobacter+jejuni+81-176+Adherence+to%2C+Invasion+of%2C+Translocation+across%2C+and+Exocytosis+from+Polarized+Human+Intestinal+Caco-2+Cells&rft.au=Hu%2C+Lan%3BTall%2C+Ben+D%3BCurtis%2C+Sherill+K%3BKopecko%2C+Dennis+J&rft.aulast=Hu&rft.aufirst=Lan&rft.date=2008-11-01&rft.volume=76&rft.issue=11&rft.spage=5294&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - endosomes; Digestive tract; Plasma membranes; Tight junctions; Membrane fusion; Intestine; Exocytosis; Invaginations; Translocation; Electron microscopy; Flagella; Campylobacter jejuni ER - TY - JOUR T1 - Porcine endogenous retroviruses and xenotransplantation AN - 19664770; 8892413 AB - Xenotransplantation is defined by the PHS as any procedure that involves the transplantation, implantation or infusion into a human recipient of either (a) live cells, tissues or organs from a nonhuman animal source, or (b) human body fluids, cells, tissues or organs that have had ex vivo contact with live nonhuman animal cells, tissues or organs (Public Health Service Guideline on Infectious Disease Issues in Xenotransplantation). Use of pigs for human xenotransplantation raises concerns about the risks of transfer of infectious agents from the pig cells to xenotransplantation recipients. The observation that the porcine germline harbors genetic loci encoding porcine endogenous retroviruses (PERVs) that are in some cases infectious for human cells has resulted in renewed scientific interest in PERVs. However, in spite of the past 10 years of investigation, the actual risk for PERV infection, replication, and pathogenic outcome in human recipients of xenotransplantation products is still undefined. JF - Cellular and Molecular Life Sciences AU - Wilson, CA AD - Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissues, and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Building 29B, Rm 5NN20, Bethesda, MD 20892 (USA), Carolyn.wilson@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 3399 EP - 3412 VL - 65 IS - 21 SN - 1420-682X, 1420-682X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Retrovirus KW - Infectious diseases KW - Replication KW - Xenografts KW - Infection KW - Body fluids KW - Public health KW - V 22320:Replication KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19664770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Life+Sciences&rft.atitle=Porcine+endogenous+retroviruses+and+xenotransplantation&rft.au=Wilson%2C+CA&rft.aulast=Wilson&rft.aufirst=CA&rft.date=2008-11-01&rft.volume=65&rft.issue=21&rft.spage=3399&rft.isbn=&rft.btitle=&rft.title=Cellular+and+Molecular+Life+Sciences&rft.issn=1420682X&rft_id=info:doi/10.1007%2Fs00018-008-8498-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Infectious diseases; Replication; Xenografts; Infection; Body fluids; Public health; Retrovirus DO - http://dx.doi.org/10.1007/s00018-008-8498-z ER - TY - JOUR T1 - Should Health-Care Providers in the United States Have Access to Influenza Vaccines Formulated for the Southern Hemisphere? AN - 19633973; 8822537 AB - BackgroundInfluenza is the most common vaccine-preventable disease in travelers. It circulates year-round in the tropics, November to March in the northern hemisphere (NH), and April to October in the southern hemisphere (SH). In 2005, approximately 8.5 million US adults aged 18 years and older traveled to the Caribbean. A similar number traveled to the tropics and the SH. SH formulation of influenza vaccine is not available in the United States. We surveyed International Society of Travel Medicine (ISTM) members to ask if they would use SH influenza vaccine if available. MethodsWe electronically mailed a survey in December 2006 to 1,251 ISTM members in the United States. We asked if respondents would use SH vaccine for patients traveling to the SH or tropics, how many such patients per week they see, and their practice location. ResultsWe received 157 responses for a response rate of 12.5%. Of these, 129 (82%) stated that they would be interested in having SH influenza vaccine available. Of those indicating interest, 73 (60%) reported seeing >10 patients traveling to the SH or tropics each week. Respondents reported practice settings in 34 states and the District of Columbia. Respondents requested more information about the likely cost of SH influenza vaccine, ordering conditions, vaccine use guidelines, comparability with NH vaccine, and approval of SH vaccine by the Food and Drug Administration. ConclusionsMany travelers to the SH are at risk for influenza infection. Although only a limited number of ISTM members responded, respondents indicated considerable interest in availability of SH influenza vaccine for their patients. More data from travel medicine and other practitioners are needed on this topic. Inquiries are being made of influenza vaccine manufacturers about licensing SH influenza vaccines in the United States. Adding SH influenza vaccine to the vaccines available to NH clinicians could help mitigate the morbidity of influenza in travelers. JF - Journal of Travel Medicine AU - Strikas, Raymond A AU - Kozarsky, Phyllis E AU - Reed, Christie AU - Kapella, Brian K AU - Freedman, David O AD - National Vaccine Program Office, Department of Health and Human Services, Washington, DC, USA, raymond.strikas@psc.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 442 EP - 446 PB - BC Decker Inc, 20 Hughson Street South VL - 15 IS - 6 SN - 1195-1982, 1195-1982 KW - Risk Abstracts KW - Travel KW - vaccines KW - Licensing KW - Morbidity KW - influenza KW - USA KW - ASW, Caribbean Sea KW - guidelines KW - Tropical environments KW - infection KW - Drugs KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19633973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Travel+Medicine&rft.atitle=Should+Health-Care+Providers+in+the+United+States+Have+Access+to+Influenza+Vaccines+Formulated+for+the+Southern+Hemisphere%3F&rft.au=Strikas%2C+Raymond+A%3BKozarsky%2C+Phyllis+E%3BReed%2C+Christie%3BKapella%2C+Brian+K%3BFreedman%2C+David+O&rft.aulast=Strikas&rft.aufirst=Raymond&rft.date=2008-11-01&rft.volume=15&rft.issue=6&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Journal+of+Travel+Medicine&rft.issn=11951982&rft_id=info:doi/10.1111%2Fj.1708-8305.2008.00254.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; ASW, Caribbean Sea; vaccines; influenza; Tropical environments; Travel; Morbidity; Licensing; guidelines; infection; Drugs DO - http://dx.doi.org/10.1111/j.1708-8305.2008.00254.x ER - TY - JOUR T1 - Diffusion behaviour of additives in polypropylene in correlation with polymer properties AN - 19617966; 8681947 AB - The migration behaviour of polymer additives in 17 polypropylene (PP) samples is described. These samples cover the major types of PP used in food packaging. The diffusion coefficients of additives with relatively small molecular masses, Mr = 136 (limonene), as well as the migration of typical antioxidants used in PP up to Mr = 1178 (IRGANOX 1010), were measured at different temperatures. In addition, the diffusion data and percentages of xylene-soluble fractions were correlated. This enables a prediction of the migration behaviour of a PP sample by testing its 'isotactic index' with xylene. The results clearly indicate that PP can be subdivided, from the migration point of view, into the monophasic homopolymer (h-PP), the monophasic random copolymer (r-PP), and the heterophasic copolymer (heco-PP). The diffusion coefficients for r-PP are at least one order of magnitude higher than those of h-PP and comparable with the values for heco-PP. Upper limits for the diffusion values can be calculated based on the safety margin required by consumer protection laws. JF - Food Additives & Contaminants Part A Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Begley, T H AU - Brandsch, J AU - Limm, W AU - Siebert, H AU - Piringer, O AD - US Food and Drug Administration, Centre for Food Safety & Applied Nutrition (CFSAN), College Park, MD, USA Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1409 EP - 1415 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 25 IS - 11 SN - 0265-203X, 0265-203X KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Antioxidants KW - Migration KW - Food additives KW - Xylene KW - Diffusion KW - Packaging KW - migration KW - Temperature KW - Food contamination KW - Consumer protection KW - consumer protection KW - Polymers KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19617966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Diffusion+behaviour+of+additives+in+polypropylene+in+correlation+with+polymer+properties&rft.au=Begley%2C+T+H%3BBrandsch%2C+J%3BLimm%2C+W%3BSiebert%2C+H%3BPiringer%2C+O&rft.aulast=Begley&rft.aufirst=T&rft.date=2008-11-01&rft.volume=25&rft.issue=11&rft.spage=1409&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=0265203X&rft_id=info:doi/10.1080%2F02652030802162747 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diffusion; Migration; Food contamination; Polymers; Food additives; Packaging; Risk assessment; Xylene; Antioxidants; Consumer protection; Temperature; migration; consumer protection DO - http://dx.doi.org/10.1080/02652030802162747 ER - TY - JOUR T1 - The safety of post-exposure vaccination of mice infected with Mycobacterium tuberculosis AN - 19615165; 8604365 AB - New post-exposure tuberculosis vaccination strategies are being developed to prevent disease in individuals latently infected with Mycobacterium tuberculosis. However, concerns about the potential induction of deleterious Koch-like reactions after immunization of persons with latent tuberculosis has limited progress in assessing the effectiveness of post-exposure vaccination. To evaluate the safety of immunization after M. tuberculosis infection, two mouse models were established, a drug treatment low bacterial burden model and an active disease model. Twelve different M. tuberculosis antigen preparations and vaccines (including DNA, subunit, viral vectored, and live, attenuated vaccines) were evaluated using these mouse models. In the low bacterial burden model, post-exposure vaccination did not induce significant reactivational disease and only injection of BCG evoked increases in lung inflammatory responses at 1 month after the immunizations. Additionally, although significant increases in lung inflammation were seen for animals injected with the hps65 DNA vaccine or a M. tuberculosis culture supernatant preparation, no differences in the survival periods were detected between vaccinated and non-vaccinated mice at 10 months post-immunization using the low bacterial burden model. For the active disease model, significantly more lung inflammation was observed at 1 month after administration of the hsp65 DNA vaccine but none of the antigen preparations tested increased the lung bacterial burdens at this early time point. Furthermore, vaccination of diseased mice with BCG or TB DNA vaccines did not significantly affect mortality rates compared to non-vaccinated controls at 10 months post-immunization. Overall, these data suggest that while the potential risk of inducing Koch-like reactions is low after immunization of persons with latent tuberculosis, extreme caution is still needed as post-exposure vaccines progress from pre-clinical experiments into the initial phases of clinical testing. JF - Vaccine AU - Derrick, Steven C AU - Perera, L P AU - Dheenadhayalan, Veerabadran AU - Yang, Amy AU - Kolibab, Kristopher AU - Morris, Sheldon L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, United States, steven.derrick@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 6092 EP - 6098 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 48 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Tuberculosis KW - Vaccine KW - Safety KW - Latent infection KW - Mortality KW - Heat shock proteins KW - Data processing KW - Animal models KW - Survival KW - Infection KW - Hsp65 protein KW - Inflammation KW - DNA vaccines KW - Lung KW - BCG KW - Drugs KW - Mycobacterium tuberculosis KW - V 22410:Animal Diseases KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19615165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=The+safety+of+post-exposure+vaccination+of+mice+infected+with+Mycobacterium+tuberculosis&rft.au=Derrick%2C+Steven+C%3BPerera%2C+L+P%3BDheenadhayalan%2C+Veerabadran%3BYang%2C+Amy%3BKolibab%2C+Kristopher%3BMorris%2C+Sheldon+L&rft.aulast=Derrick&rft.aufirst=Steven&rft.date=2008-11-01&rft.volume=26&rft.issue=48&rft.spage=6092&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.09.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Latent infection; Heat shock proteins; Data processing; Animal models; Survival; Hsp65 protein; Infection; Inflammation; DNA vaccines; BCG; Lung; Tuberculosis; Drugs; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1016/j.vaccine.2008.09.011 ER - TY - JOUR T1 - Engineering Case Reports AN - 19605804; 8502109 AB - Abstract not available. JF - Journal of Occupational and Environmental Hygiene AU - Old, Leo AU - Dunn, Kevin H AU - Garcia, Alberto AU - Echt, Alan AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - D103 EP - D110 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 11 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts KW - Safety engineering KW - Occupational safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19605804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Engineering+Case+Reports&rft.au=Old%2C+Leo%3BDunn%2C+Kevin+H%3BGarcia%2C+Alberto%3BEcht%2C+Alan&rft.aulast=Old&rft.aufirst=Leo&rft.date=2008-11-01&rft.volume=5&rft.issue=11&rft.spage=D103&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802363274 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Safety engineering; Occupational safety DO - http://dx.doi.org/10.1080/15459620802363274 ER - TY - JOUR T1 - Enumeration of Mycobacterium leprae Using Real-Time PCR AN - 19568913; 8819512 AB - Mycobacterium leprae is not cultivable in axenic media, and direct microscopic enumeration of the bacilli is complex, labor intensive, and suffers from limited sensitivity and specificity. We have developed a real-time PCR assay for quantifying M. leprae DNA in biological samples. Primers were identified to amplify a shared region of the multicopy repeat sequence (RLEP) specific to M. leprae and tested for sensitivity and specificity in the TaqMan format. The assay was specific for M. leprae and able to detect 10 fg of purified M. leprae DNA, or approximately 300 bacteria in infected tissues. We used the RLEP TaqMan PCR to assess the short and long-term growth results of M. leprae in foot pad tissues obtained from conventional mice, a gene knock-out mouse strain, athymic nude mice, as well as from reticuloendothelial tissues of M. leprae-infected nine-banded armadillos. We found excellent correlative results between estimates from RLEP TaqMan PCR and direct microscopic counting (combined r=0.98). The RLEP TaqMan PCR permitted rapid analysis of batch samples with high reproducibility and is especially valuable for detection of low numbers of bacilli. Molecular enumeration is a rapid, objective and highly reproducible means to estimate the numbers of M. leprae in tissues, and application of the technique can facilitate work with this agent in many laboratories. Author Summary Mycobacterium leprae is not cultivable in axenic media, and direct microscopic enumeration of the bacilli is complex, labor intensive, and suffers from limited sensitivity and specificity. We describe the use of real-time PCR to provide a rapid, objective and consistent enumeration procedure for M. leprae. The procedure is specific for M. leprae, has a dynamic range of approximately 6 logs and yields results in only a few hours, including processing time. The procedure was applied to M. leprae growing in mouse and armadillo tissues showing excellent correlation with microscopic counting. The benefits of this technique for experimental characterization of leprosy infections and vaccine trials are substantial, and potential applications to clinical specimens could impact patient management by simplifying the assessment of bacterial burden prior to and during drug treatment. JF - PLoS Neglected Tropical Diseases AU - Truman, Richard W AU - Andrews, PKyle AU - Robbins, Naoko Y AU - Adams, Linda B AU - Krahenbuhl, James L AU - Gillis, Thomas P AU - Small, Pamela LC AD - Department of Health and Human Services, Health Resources Services Administration, Bureau of Primary Health Care, National Hansen's Disease Programs, Baton Rouge, Louisiana, United States of America Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 2 IS - 11 SN - 1935-2727, 1935-2727 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacilli KW - Mycobacterium leprae KW - Enumeration KW - Infection KW - Clinical trials KW - Leprosy KW - Foot KW - Polymerase chain reaction KW - Primers KW - Vaccines KW - Armadillo KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19568913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Enumeration+of+Mycobacterium+leprae+Using+Real-Time+PCR&rft.au=Truman%2C+Richard+W%3BAndrews%2C+PKyle%3BRobbins%2C+Naoko+Y%3BAdams%2C+Linda+B%3BKrahenbuhl%2C+James+L%3BGillis%2C+Thomas+P%3BSmall%2C+Pamela+LC&rft.aulast=Truman&rft.aufirst=Richard&rft.date=2008-11-01&rft.volume=2&rft.issue=11&rft.spage=e328&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0000328 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bacilli; Foot; Polymerase chain reaction; Primers; Vaccines; Enumeration; Infection; Drugs; Clinical trials; Leprosy; Mycobacterium leprae; Armadillo DO - http://dx.doi.org/10.1371/journal.pntd.0000328 ER - TY - JOUR T1 - US Food and Drug Administration's Total Diet Study: Dietary intake of perchlorate and iodine AN - 19565928; 8831613 AB - The US Food and Drug Administration (FDA) has conducted the Total Diet Study (TDS) since 1961, which designed to monitor the US food supply for chemical contaminants, nutritional elements, and toxic elements. Recently, perchlorate was analyzed in TDS samples. Perchlorate is used as an oxidizing agent in rocket propellant, is found in other items (e.g., explosives, road flares, fireworks, and car airbags), occurs naturally in some fertilizers, and may be generated under certain climatic conditions. It has been detected in surface and groundwater and in food. Perchlorate at high (e.g., pharmacological) doses can interfere with iodide uptake into the thyroid gland, disrupting its function. The National Academy of Sciences (NAS) has identified that "the fetuses of pregnant women who might have hypothyroidism or iodide deficiency as the most sensitive population." This study reports on intake estimates of perchlorate and iodine, a precursor to iodide, using the analytical results from the TDS. Estimated average perchlorate and iodine daily intakes as well as the contribution of specific food groups to total intakes were estimated for 14 age/sex subgroups of the US population. The estimated smallest lower bound to the largest upper bound average perchlorate intakes by the 14 age/sex groups range from 0.08 to 0.39 micrograms per kilogram body weight per day ( mu g/kg bw/day), compared with the US Environmental Protection Agency (EPA) reference dose (RfD) of 0.7 mu g/kg bw/day. Infants and children demonstrated the highest estimated intakes of perchlorate on a body weight basis. The estimated average iodine intakes by the 14 age/sex groups reveal a lower bound (ND=o) and upper bound (ND=LOD) range of average intakes from 138 to 353 mu g/person/day. Estimated iodine intakes by infants 6-11 months exceed their adequate intake (AI), and intakes by children and adult age/sex groups exceed their relevant estimated average requirement (EAR). JF - Journal of Exposure Science and Environmental Epidemiology AU - Murray, C W AU - Egan, S K AU - Kim, H AU - Beru, N AU - Bolger, P M AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-301, College Park, MD 20740-3835, USA, Clarence.Murray@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 571 EP - 580 VL - 18 IS - 6 SN - 1559-0631, 1559-0631 KW - Pollution Abstracts KW - Age KW - Propellants KW - Fertilizers KW - Iodine KW - body weight KW - Drugs KW - Diets KW - age groups KW - iodides KW - Thyroid KW - Ingestion KW - Children KW - perchlorate KW - Pregnancy KW - EPA KW - USA KW - FDA KW - Explosives KW - Air bags KW - Infants KW - P 2000:FRESHWATER POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19565928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=US+Food+and+Drug+Administration%27s+Total+Diet+Study%3A+Dietary+intake+of+perchlorate+and+iodine&rft.au=Murray%2C+C+W%3BEgan%2C+S+K%3BKim%2C+H%3BBeru%2C+N%3BBolger%2C+P+M&rft.aulast=Murray&rft.aufirst=C&rft.date=2008-11-01&rft.volume=18&rft.issue=6&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fsj.jes.7500648 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diets; age groups; Age; iodides; Propellants; Thyroid; Children; Ingestion; perchlorate; Pregnancy; EPA; Fertilizers; FDA; Iodine; Explosives; Air bags; Drugs; body weight; Infants; USA DO - http://dx.doi.org/10.1038/sj.jes.7500648 ER - TY - JOUR T1 - Inactivation of Escherichia coli O157:H7, Salmonella typhimurium, and Listeria monocytogenes on Stored Iceberg Lettuce by Aqueous Chlorine Dioxide Treatment AN - 19559000; 8783775 AB - Inactivation of Escherichia coli O157:H7, Salmonella typhimurium, and Listeria monocytogenes in iceberg lettuce by aqueous chlorine dioxide (ClO sub(2)) treatment was evaluated. Iceberg lettuce samples were inoculated with approximately 7 log CFU-g of E. coli O157:H7, S. typhimurium, and L. monocytogenes. Iceberg lettuce samples were then treated with 0, 5, 10, or 50 ppm ClO sub(2) solution and stored at 4 degree C. Aqueous ClO sub(2) treatment significantly decreased the populations of pathogenic bacteria on shredded lettuce (P < 0.05). In particular, 50 ppm ClO sub(2) treatment reduced E. coli O157:H7, S. typhimurium, and L. monocytogenes by 1.44, 1.95, and 1.20 log CFU-g, respectively. The D sub(10)-values of E. coli O157:H7, S. typhimurium, and L. monocytogenes in shredded lettuce were 11, 26, and 42 ppm, respectively. The effect of aqueous ClO sub(2) treatment on the growth of pathogenic bacteria during storage was evaluated, and a decrease in the population size of these pathogenic bacteria was observed. Additionally, aqueous ClO sub(2) treatment did not affect the color of lettuce during storage. These results suggest that aqueous ClO sub(2) treatment can be used to improve the microbial safety of shredded lettuce during storage. JF - Journal of Food Science AU - Kim, Yun-Jung AU - Lee, Seung-Hwan AU - Park, Jiyong AU - Park, Jonghyun AU - Chung, Myongsoo AU - Kwon, Kisung AU - Chung, Kyungsook AU - Won, Misun AU - Song, Kyung Bin AD - Authors Yun-Jung Kim, Seung-Hwan Lee, and Kyung Bin Song are with Dept. of Food Science and Technology, Chungnam National Univ., Daejeon, 305-764, Korea. Author Jiyong Park is with Dept. of Biotechnology, Yonsei Univ., Seoul, 120-749, Korea. Author Jonghyun Park is with Dept. of Food Science and Biotechnology, Kyungwon Univ., Sungnam, 461-701, Korea. Author Myongsoo Chung is with Dept. of Food Science, Ehwa Women's Univ., Seoul, 120-750, Korea. Author Kisung Kwon is with Center for Food Safety Evaluation, Korea Food and Drug Administration, Seoul, 122-704, Korea. Authors Kyungsook Chung and Misun Won are with Korea Research Inst. of Bioscience and Biotechnology, Daejeon, 305-806, Korea. Direct inquiries to author Kyung Bin Song ( Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - M418 EP - M422 PB - Institute of Food Technology VL - 73 IS - 9 SN - 0022-1147, 0022-1147 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - aqueous chlorine dioxide KW - D-value KW - iceberg lettuce KW - microbial growth KW - storage KW - Listeria monocytogenes KW - Chlorine dioxide KW - Icebergs KW - Escherichia coli KW - Salmonella typhimurium KW - Color KW - A 01330:Food Microbiology KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19559000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Inactivation+of+Escherichia+coli+O157%3AH7%2C+Salmonella+typhimurium%2C+and+Listeria+monocytogenes+on+Stored+Iceberg+Lettuce+by+Aqueous+Chlorine+Dioxide+Treatment&rft.au=Kim%2C+Yun-Jung%3BLee%2C+Seung-Hwan%3BPark%2C+Jiyong%3BPark%2C+Jonghyun%3BChung%2C+Myongsoo%3BKwon%2C+Kisung%3BChung%2C+Kyungsook%3BWon%2C+Misun%3BSong%2C+Kyung+Bin&rft.aulast=Kim&rft.aufirst=Yun-Jung&rft.date=2008-11-01&rft.volume=73&rft.issue=9&rft.spage=M418&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2Fj.1750-3841.2008.00940.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chlorine dioxide; Icebergs; Color; Listeria monocytogenes; Escherichia coli; Salmonella typhimurium DO - http://dx.doi.org/10.1111/j.1750-3841.2008.00940.x ER - TY - JOUR T1 - Transient Exposure to Transforming Growth Factor Beta 3 Under Serum-Free Conditions Enhances the Biomechanical and Biochemical Maturation of Tissue-Engineered Cartilage AN - 19512613; 8833721 AB - A goal of cartilage tissue engineering is the production of cell-laden constructs possessing sufficient mechanical and biochemical features to enable native tissue function. This study details a systematic characterization of a serum-free (SF) culture methodology employing transient growth factor supplementation to promote robust maturation of tissue-engineered cartilage. Bovine chondrocyte agarose hydrogel constructs were cultured under free-swelling conditions in serum-containing or SF medium supplemented continuously or transiently with varying doses of transforming growth factor beta 3 (TGF- beta 3). Constructs were harvested weekly or bi-weekly and assessed for mechanical and biochemical properties. Transient exposure (2 weeks) to low concentrations (2.5-5 ng/mL) of TGF- beta 3 in chemically defined medium facilitated robust and highly reproducible construct maturation. Constructs receiving transient TGF- beta 3 exposure achieved native tissue levels of compressive modulus (0.8 MPa) and proteoglycan content (6-7% of wet weight) after less than 2 months of in vitro culture. This maturation response was far superior to that observed after continuous growth factor supplementation or transient TGF- beta 3 treatment in the presence of serum. These findings represent a significant advance in developing an ex vivo culture methodology to promote production of clinically relevant and mechanically competent tissue-engineered cartilage constructs for implantation to repair damaged articular surfaces. JF - Tissue Engineering, Part A: Tissue Engineering AU - Byers, BA AU - Mauck, R L AU - Chiang, I E AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, 50 South Drive, Building 50, Room 1503, MSC 8022, Bethesda, MD 20892, USA, tuanr@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1821 EP - 1834 VL - 14 IS - 11 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - Proteoglycans KW - hydrogels KW - Cartilage KW - Chondrocytes KW - Transforming growth factor-^b KW - Cell culture KW - Tissue engineering KW - Supplementation KW - Transforming growth factor-^b1 KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19512613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Transient+Exposure+to+Transforming+Growth+Factor+Beta+3+Under+Serum-Free+Conditions+Enhances+the+Biomechanical+and+Biochemical+Maturation+of+Tissue-Engineered+Cartilage&rft.au=Byers%2C+BA%3BMauck%2C+R+L%3BChiang%2C+I+E%3BTuan%2C+R+S&rft.aulast=Byers&rft.aufirst=BA&rft.date=2008-11-01&rft.volume=14&rft.issue=11&rft.spage=1821&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2007.0222 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Tissue engineering; Transforming growth factor-^b; Cartilage; Cell culture; Transforming growth factor-^b1; Supplementation; Proteoglycans; Chondrocytes; hydrogels DO - http://dx.doi.org/10.1089/ten.tea.2007.0222 ER - TY - JOUR T1 - Determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in food and paper packaging materials from US marketplaces AN - 19335412; 8681948 AB - A gas chromatography-ion-trap tandem mass spectrometry procedure was developed for the determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in domestic and imported paper packages and food sold in US marketplaces. The procedure involved ultrasonic extraction with dichloromethane, followed by analysis with the gas chromatography-ion-trap tandem mass spectrometry. Calibration curves for DIPN and DBP were achieved with concentrations ranging from 0.01 to 10 mg ml-1 and the corresponding r2 values were 0.9976 and 0.9956, respectively. In most of the fortified samples the recoveries were higher than 80% with a relative standard deviation (RSD) <10%. Using this procedure, it was found that less than 20% of the tested domestic packages and more than 60% of the tested imported food packages contained both DIPN and DBP. The concentrations of DIPN and DBP ranged from 0.09 to 20 mg kg-1 and 0.14 to 55 mg kg-1, respectively, with most of the DINP and DBP levels lower than 20 mg kg-1. DIPN was not detected (<0.01 mg kg-1) in 41 food samples and DBP was only detected in two domestic and four imported food samples with concentrations ranging from <0.01 to 0.81 mg kg-1. JF - Food Additives & Contaminants Part A Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Zhang, K AU - Noonan, G O AU - Begley, T H AD - US Food and Drug Administration, Centre for Food Safety & Applied Nutrition (CFSAN), MD, USA Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1416 EP - 1423 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 25 IS - 11 SN - 0265-203X, 0265-203X KW - Risk Abstracts KW - Risk assessment KW - Food additives KW - USA KW - Ultrasonics KW - Mass spectrometry KW - packaging materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19335412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Determination+of+2%2C6-diisopropylnaphthalene+%28DIPN%29+and+n-dibutylphthalate+%28DBP%29+in+food+and+paper+packaging+materials+from+US+marketplaces&rft.au=Zhang%2C+K%3BNoonan%2C+G+O%3BBegley%2C+T+H&rft.aulast=Zhang&rft.aufirst=K&rft.date=2008-11-01&rft.volume=25&rft.issue=11&rft.spage=1416&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=0265203X&rft_id=info:doi/10.1080%2F02652030802163380 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Mass spectrometry; Ultrasonics; Risk assessment; Food additives; packaging materials DO - http://dx.doi.org/10.1080/02652030802163380 ER - TY - JOUR T1 - Toll-free number for reporting adverse events on labeling for human drug products. Final rule. AN - 69923263; 19112682 AB - The Food and Drug Administration (FDA) is issuing a final rule that confirms the interim final rule entitled "Toll-Free Number for Reporting Adverse Events on Labeling for Human Drug Products" (73 FR 402, January 3, 2008) (interim final rule) and responds to comments submitted in response to the request for comments in the proposed rule of the same title (69 FR 21778, April 22, 2004) (proposed rule). This final rule affirms the interim final rule's requirement for the addition of a statement to the labeling for certain human drug products for which an application is approved under section 505 of the Federal Food, Drug, and Cosmetic Act (the act). The statement includes a toll-free number and advises that the number is to be used only for reporting side effects and is not intended for medical advice (the side effects statement). This final rule also affirms the interim final rule's addition of new part 209 to the regulations requiring distribution of the side effects statement. This final rule implements provisions of the Best Pharmaceuticals for Children Act (the BPCA) and the Food and Drug Administration Amendments Act of 2007 (FDAAA). JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2008/10/28/ PY - 2008 DA - 2008 Oct 28 SP - 63886 EP - 63897 VL - 73 IS - 209 SN - 0097-6326, 0097-6326 KW - Prescription Drugs KW - 0 KW - Health technology assessment KW - United States KW - Humans KW - Adverse Drug Reaction Reporting Systems -- legislation & jurisprudence KW - Drug Labeling -- legislation & jurisprudence KW - Hotlines -- legislation & jurisprudence KW - Drug Industry -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69923263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Toll-free+number+for+reporting+adverse+events+on+labeling+for+human+drug+products.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2008-10-28&rft.volume=73&rft.issue=209&rft.spage=63886&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-02 N1 - Date created - 2008-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - National Estimate of Workers Exposed to Hazardous Workplace Noise --- United States, 1999--2004 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41871865; 5070260 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Tak, SangWoo AU - Calvert, Geoffrey Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Noise levels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41871865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=National+Estimate+of+Workers+Exposed+to+Hazardous+Workplace+Noise+---+United+States%2C+1999--2004&rft.au=Tak%2C+SangWoo%3BCalvert%2C+Geoffrey&rft.aulast=Tak&rft.aufirst=SangWoo&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regional collaboration on a Shigellosis issue T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41864467; 5069270 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Thorne, Brenda AU - Slentz, Monica AU - Martinez, Diana AU - Kilborn, Cindy AU - Lin, Huai AU - Short, Kirstin AU - Awosika-Olumo, Adebowale AU - Partridge, Christa AU - Beckham, Dana AU - Cuellar, Sandra AU - Valcin, Randy AU - Prejean, Jan Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Shigellosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Regional+collaboration+on+a+Shigellosis+issue&rft.au=Thorne%2C+Brenda%3BSlentz%2C+Monica%3BMartinez%2C+Diana%3BKilborn%2C+Cindy%3BLin%2C+Huai%3BShort%2C+Kirstin%3BAwosika-Olumo%2C+Adebowale%3BPartridge%2C+Christa%3BBeckham%2C+Dana%3BCuellar%2C+Sandra%3BValcin%2C+Randy%3BPrejean%2C+Jan&rft.aulast=Thorne&rft.aufirst=Brenda&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using the Environmental Public Health Performance Standards to improve environmental health infrastructure and services to tribal communities T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41863862; 5069091 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Davis, Celeste Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Public health KW - Infrastructure KW - Environmental health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41863862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Using+the+Environmental+Public+Health+Performance+Standards+to+improve+environmental+health+infrastructure+and+services+to+tribal+communities&rft.au=Davis%2C+Celeste&rft.aulast=Davis&rft.aufirst=Celeste&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of question type, reference period and sensitivity on item reliability in the National Survey on Drug Use and Health T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41863335; 5070710 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Kennet, Joel AU - Painter, Dicy AU - Feder, Moshe AU - Snodgrass, Jeanne AU - Piper, Lanny Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Sensitivity KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41863335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Influence+of+question+type%2C+reference+period+and+sensitivity+on+item+reliability+in+the+National+Survey+on+Drug+Use+and+Health&rft.au=Kennet%2C+Joel%3BPainter%2C+Dicy%3BFeder%2C+Moshe%3BSnodgrass%2C+Jeanne%3BPiper%2C+Lanny&rft.aulast=Kennet&rft.aufirst=Joel&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 2006 HIV incidence and prevalence in Houston/Harris County, TX T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41861538; 5067059 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Yang, Biru AU - Chan, Shirley AU - Mohammad, Naqi AU - Wolverton, Marcia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA, Texas, Houston KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=2006+HIV+incidence+and+prevalence+in+Houston%2FHarris+County%2C+TX&rft.au=Yang%2C+Biru%3BChan%2C+Shirley%3BMohammad%2C+Naqi%3BWolverton%2C+Marcia&rft.aulast=Yang&rft.aufirst=Biru&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of chronic obstructive pulmonary disease in the U.S. working population: A study of the 1997-2004 National Health Interview Survey data T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41854038; 5070262 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Bang, Ki AU - Syamlal, Girija AU - Mazurek, Jacek Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Chronic obstructive pulmonary disease KW - Data processing KW - Population studies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Prevalence+of+chronic+obstructive+pulmonary+disease+in+the+U.S.+working+population%3A+A+study+of+the+1997-2004+National+Health+Interview+Survey+data&rft.au=Bang%2C+Ki%3BSyamlal%2C+Girija%3BMazurek%2C+Jacek&rft.aulast=Bang&rft.aufirst=Ki&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two norovirus outbreaks: Same nurse manager, different outcomes T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41854017; 5069427 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Long, Stephen AU - Zhang, Yufang AU - Thorne, Brenda AU - Awosika-Olumo, Adebowale Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Nursing KW - Outbreaks KW - Medical personnel KW - Norovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Two+norovirus+outbreaks%3A+Same+nurse+manager%2C+different+outcomes&rft.au=Long%2C+Stephen%3BZhang%2C+Yufang%3BThorne%2C+Brenda%3BAwosika-Olumo%2C+Adebowale&rft.aulast=Long&rft.aufirst=Stephen&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multivariate analysis of state variation in underinsurance among children with special health care needs in the US, 2005-06 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41851885; 5067369 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Kogan, Michael AU - Newacheck, Paul AU - Strickland, Bonnie AU - Blumberg, Stephen AU - Singh, Gopal AU - Zeni, Mary AU - Honberg, Lynda AU - Free, Heather AU - Heyman, Kathleen Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Children KW - Health care KW - Multivariate analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Multivariate+analysis+of+state+variation+in+underinsurance+among+children+with+special+health+care+needs+in+the+US%2C+2005-06&rft.au=Kogan%2C+Michael%3BNewacheck%2C+Paul%3BStrickland%2C+Bonnie%3BBlumberg%2C+Stephen%3BSingh%2C+Gopal%3BZeni%2C+Mary%3BHonberg%2C+Lynda%3BFree%2C+Heather%3BHeyman%2C+Kathleen&rft.aulast=Kogan&rft.aufirst=Michael&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IRB panel members perceptions of their role in the review of scientific methodology: A qualitative study T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41851827; 5070839 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Gellar, Lauren AU - Candilis, Philip AU - Garverich, Suzanne AU - Jackson, Christopher AU - Lidz, Chuck AU - Roach, Teresa Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Reviews KW - Perception KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=IRB+panel+members+perceptions+of+their+role+in+the+review+of+scientific+methodology%3A+A+qualitative+study&rft.au=Gellar%2C+Lauren%3BCandilis%2C+Philip%3BGarverich%2C+Suzanne%3BJackson%2C+Christopher%3BLidz%2C+Chuck%3BRoach%2C+Teresa&rft.aulast=Gellar&rft.aufirst=Lauren&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.htmlhttp://www.tms. org/Meetings/Annual-09/PDFs/AM09finalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigation of a Potential Mass Rabies Exposure T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41849323; 5069327 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Short, Kirstin AU - Persse, David AU - Awosika-Olumo, Adebowale AU - Ramon, Melanie AU - Grunenwald, Paul AU - Johnson, Gary Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Rabies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Investigation+of+a+Potential+Mass+Rabies+Exposure&rft.au=Short%2C+Kirstin%3BPersse%2C+David%3BAwosika-Olumo%2C+Adebowale%3BRamon%2C+Melanie%3BGrunenwald%2C+Paul%3BJohnson%2C+Gary&rft.aulast=Short&rft.aufirst=Kirstin&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Applications of American Time Use Survey to worker safety and health T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41848881; 5069760 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Chen, Guang Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Health and safety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Applications+of+American+Time+Use+Survey+to+worker+safety+and+health&rft.au=Chen%2C+Guang&rft.aulast=Chen&rft.aufirst=Guang&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Potentially productive years of life lost due to pneumoconiosis mortality in the United States, 1968-2004 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41848767; 5067789 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Mazurek, Jacek AU - Wood, John Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Pneumoconiosis KW - Mortality KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Potentially+productive+years+of+life+lost+due+to+pneumoconiosis+mortality+in+the+United+States%2C+1968-2004&rft.au=Mazurek%2C+Jacek%3BWood%2C+John&rft.aulast=Mazurek&rft.aufirst=Jacek&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An innovative method used to improve birh disparities among women of color T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41848636; 5070072 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Patterson, Pam AU - Mitchell, Carolyn Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Color KW - Methodology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=An+innovative+method+used+to+improve+birh+disparities+among+women+of+color&rft.au=Patterson%2C+Pam%3BMitchell%2C+Carolyn&rft.aulast=Patterson&rft.aufirst=Pam&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy People 2020: Preview the next decade's national objectives T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41846644; 5065146 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Royall, Penelope AU - Blakey, Carter AU - Horton, Mark Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Healthy+People+2020%3A+Preview+the+next+decade%27s+national+objectives&rft.au=Royall%2C+Penelope%3BBlakey%2C+Carter%3BHorton%2C+Mark&rft.aulast=Royall&rft.aufirst=Penelope&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Massachusetts Mental Health / Criminal Justice Cohort Study: What We've Learned T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41843656; 5067787 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Fisher, William AU - Roy-Bujnowski, Kristen AU - Banks, Steven AU - Grudzinskas, Albert AU - Simon, Lorna AU - Clayfield, Jonathan AU - Wolff, Nancy Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA, Massachusetts KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41843656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Massachusetts+Mental+Health+%2F+Criminal+Justice+Cohort+Study%3A+What+We%27ve+Learned&rft.au=Fisher%2C+William%3BRoy-Bujnowski%2C+Kristen%3BBanks%2C+Steven%3BGrudzinskas%2C+Albert%3BSimon%2C+Lorna%3BClayfield%2C+Jonathan%3BWolff%2C+Nancy&rft.aulast=Fisher&rft.aufirst=William&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Introduction to and overview of SAMHSA and CSAT's Screening, Brief Intervention and Referral to Treatment initiative T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41842460; 5068861 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Stein, Jack Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Intervention KW - Reviews KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41842460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Introduction+to+and+overview+of+SAMHSA+and+CSAT%27s+Screening%2C+Brief+Intervention+and+Referral+to+Treatment+initiative&rft.au=Stein%2C+Jack&rft.aulast=Stein&rft.aufirst=Jack&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender Differences in the Progression to AIDS and Mortality in the Houston Surveillance Project T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41838619; 5067169 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Arafat, Raouf AU - Awosika-olumo, Adebowale AU - Wolverton, Marcia AU - Gomez, James AU - Anderson, Lydwina Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA, Texas, Houston KW - Sex KW - Mortality KW - Acquired immune deficiency syndrome KW - Sex differences KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Gender+Differences+in+the+Progression+to+AIDS+and+Mortality+in+the+Houston+Surveillance+Project&rft.au=Arafat%2C+Raouf%3BAwosika-olumo%2C+Adebowale%3BWolverton%2C+Marcia%3BGomez%2C+James%3BAnderson%2C+Lydwina&rft.aulast=Arafat&rft.aufirst=Raouf&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Young adult tobacco program (YATO): Developing a model for tobacco cessation T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41837933; 5068803 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - McHugh, Meaghan AU - Hall, Margruetta AU - Holt, Mica AU - Dankwa-Mullan, Irene Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Tobacco KW - Young adults KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41837933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Young+adult+tobacco+program+%28YATO%29%3A+Developing+a+model+for+tobacco+cessation&rft.au=McHugh%2C+Meaghan%3BHall%2C+Margruetta%3BHolt%2C+Mica%3BDankwa-Mullan%2C+Irene&rft.aulast=McHugh&rft.aufirst=Meaghan&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Qualitative Approach to Inform Practice: Innovative Supports for Alzheimer's Caregivers T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41837925; 5067649 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Richardson, Clemelia AU - Paul, Janice Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Neurodegenerative diseases KW - Alzheimer's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41837925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=A+Qualitative+Approach+to+Inform+Practice%3A+Innovative+Supports+for+Alzheimer%27s+Caregivers&rft.au=Richardson%2C+Clemelia%3BPaul%2C+Janice&rft.aulast=Richardson&rft.aufirst=Clemelia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Decade of Occupational Mortality in Law Enforcement: Census of Fatal Occupational Injuries, 1992-2002 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41837275; 5070265 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Tiesman, Hope AU - Hendricks, Scott AU - Amandus, Harlan Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Census KW - Law enforcement KW - Mortality KW - Occupational safety KW - Injuries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41837275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=A+Decade+of+Occupational+Mortality+in+Law+Enforcement%3A+Census+of+Fatal+Occupational+Injuries%2C+1992-2002&rft.au=Tiesman%2C+Hope%3BHendricks%2C+Scott%3BAmandus%2C+Harlan&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Asthma Management Education among Low-Income Latinos: A Model for Intervention T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41836403; 5066100 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Aguirre, Luis AU - Fernan-Zegarra, Paola AU - Mora, Sonia AU - Newton, Nancy Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Respiratory diseases KW - Asthma KW - Socio-economic aspects KW - Intervention KW - Ethnic groups KW - Education KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41836403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Asthma+Management+Education+among+Low-Income+Latinos%3A+A+Model+for+Intervention&rft.au=Aguirre%2C+Luis%3BFernan-Zegarra%2C+Paola%3BMora%2C+Sonia%3BNewton%2C+Nancy&rft.aulast=Aguirre&rft.aufirst=Luis&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A proposed National Health Interview Survey supplement for occupational health surveillance T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41834564; 5067686 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Luckhaupt, Sara Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Occupational health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=A+proposed+National+Health+Interview+Survey+supplement+for+occupational+health+surveillance&rft.au=Luckhaupt%2C+Sara&rft.aulast=Luckhaupt&rft.aufirst=Sara&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integrating Rapid HIV Testing into Substance Abuse and Mental Health Settings Nationally: The Substance Abuse and Mental Health Services Administration Rapid HIV Testing Initiative T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41830395; 5067277 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - James, Kirk AU - House, Laura AU - Hewitt, Warren AU - Thompson, David AU - Jones, Stella AU - Carrington, Stephen AU - Clark, Westley Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Human immunodeficiency virus KW - Substance abuse KW - Mental disorders KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41830395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Integrating+Rapid+HIV+Testing+into+Substance+Abuse+and+Mental+Health+Settings+Nationally%3A+The+Substance+Abuse+and+Mental+Health+Services+Administration+Rapid+HIV+Testing+Initiative&rft.au=James%2C+Kirk%3BHouse%2C+Laura%3BHewitt%2C+Warren%3BThompson%2C+David%3BJones%2C+Stella%3BCarrington%2C+Stephen%3BClark%2C+Westley&rft.aulast=James&rft.aufirst=Kirk&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy People 2020: Shaping the next decade's disease prevention and health promotion agenda T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41829134; 5068368 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Blakey, Carter AU - Royall, Penelope AU - Horton, Mark AU - Klein, Richard Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Health promotion KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41829134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Healthy+People+2020%3A+Shaping+the+next+decade%27s+disease+prevention+and+health+promotion+agenda&rft.au=Blakey%2C+Carter%3BRoyall%2C+Penelope%3BHorton%2C+Mark%3BKlein%2C+Richard&rft.aulast=Blakey&rft.aufirst=Carter&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender health on the US-Mexico border T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41827503; 5066305 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Correa de Araujo, Rosaly Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41827503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Gender+health+on+the+US-Mexico+border&rft.au=Correa+de+Araujo%2C+Rosaly&rft.aulast=Correa+de+Araujo&rft.aufirst=Rosaly&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developing an occupational health surveillance needs assessment in NH: A stakeholder driven process T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41826997; 5067688 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Armenti, Karla Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Stakeholders KW - Occupational health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41826997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Developing+an+occupational+health+surveillance+needs+assessment+in+NH%3A+A+stakeholder+driven+process&rft.au=Armenti%2C+Karla&rft.aulast=Armenti&rft.aufirst=Karla&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reproductive Health communication between Parents and Adolescents falls short T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41826265; 5067623 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Patterson, Pamela AU - Ford, Calvin Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Adolescents KW - Communication KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41826265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Reproductive+Health+communication+between+Parents+and+Adolescents+falls+short&rft.au=Patterson%2C+Pamela%3BFord%2C+Calvin&rft.aulast=Patterson&rft.aufirst=Pamela&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy of self-reported secondhand smoke exposure in NHANES 1988-2002 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41811116; 5070264 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Arheart, Kristopher AU - Lee, David AU - Fleming, Lora AU - LeBlanc, William AU - Dietz, Noella AU - McCollister, Kathryn AU - Wilkinson, James AU - Lewis, John AU - Clark, John AU - Davila, Evelyn AU - Bandiera, Frank Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Passive smoking KW - Smoke KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41811116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Accuracy+of+self-reported+secondhand+smoke+exposure+in+NHANES+1988-2002&rft.au=Arheart%2C+Kristopher%3BLee%2C+David%3BFleming%2C+Lora%3BLeBlanc%2C+William%3BDietz%2C+Noella%3BMcCollister%2C+Kathryn%3BWilkinson%2C+James%3BLewis%2C+John%3BClark%2C+John%3BDavila%2C+Evelyn%3BBandiera%2C+Frank&rft.aulast=Arheart&rft.aufirst=Kristopher&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Promotoras to improve access to behavioral health services T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41810465; 5065872 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Stotz, Diana AU - Sewell, Erin Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41810465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Using+Promotoras+to+improve+access+to+behavioral+health+services&rft.au=Stotz%2C+Diana%3BSewell%2C+Erin&rft.aulast=Stotz&rft.aufirst=Diana&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dramatic Increases in Obesity and Overweight Prevalence among Ethnic-Immigrant and Social Class Groups in the United States, 1991-2006 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41808866; 5065759 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Singh, Gopal AU - Siahpush, Mohammad AU - Hiatt, Robert Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Obesity KW - Social class KW - Body weight KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41808866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Dramatic+Increases+in+Obesity+and+Overweight+Prevalence+among+Ethnic-Immigrant+and+Social+Class+Groups+in+the+United+States%2C+1991-2006&rft.au=Singh%2C+Gopal%3BSiahpush%2C+Mohammad%3BHiatt%2C+Robert&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Spiritual Well-Being and Social Support on Caregiver Well-Being Among Grandparent and Other Kinship Caregivers - NEW PRESENTER T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41808472; 5070696 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Richardson, Clemelia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Social interactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41808472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Impact+of+Spiritual+Well-Being+and+Social+Support+on+Caregiver+Well-Being+Among+Grandparent+and+Other+Kinship+Caregivers+-+NEW+PRESENTER&rft.au=Richardson%2C+Clemelia&rft.aulast=Richardson&rft.aufirst=Clemelia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of surveillance data to investigate false positive HIV Western Blots in pregnant women T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41805228; 5067050 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Chan, Shirley AU - Yang, Biru AU - Wolverton, Marcia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Human immunodeficiency virus KW - Pregnancy KW - Data processing KW - Western blotting KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41805228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Use+of+surveillance+data+to+investigate+false+positive+HIV+Western+Blots+in+pregnant+women&rft.au=Chan%2C+Shirley%3BYang%2C+Biru%3BWolverton%2C+Marcia&rft.aulast=Chan&rft.aufirst=Shirley&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Community-Based Prostate Cancer Screening for High-Risk Minority and Immigrant Populations: Prostate Cancer Incidence and Implications for Public Health Screenings T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41802579; 5069378 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Dankwa-Mullan, Irene AU - Joseph, Katty AU - Holt, Charlene Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Prostate cancer KW - Public health KW - Immigrants KW - Community involvement KW - Risk groups KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41802579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Community-Based+Prostate+Cancer+Screening+for+High-Risk+Minority+and+Immigrant+Populations%3A+Prostate+Cancer+Incidence+and+Implications+for+Public+Health+Screenings&rft.au=Dankwa-Mullan%2C+Irene%3BJoseph%2C+Katty%3BHolt%2C+Charlene&rft.aulast=Dankwa-Mullan&rft.aufirst=Irene&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - US Government Involvement in Health Issues in Vietnam T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41802295; 5066421 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Sweeney, Marie Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Vietnam KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41802295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=US+Government+Involvement+in+Health+Issues+in+Vietnam&rft.au=Sweeney%2C+Marie&rft.aulast=Sweeney&rft.aufirst=Marie&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender-Responsive Training: Addressing the needs of incarcerated women and girls T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41801813; 5068161 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Hoersch, Michelle Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Training KW - Prisons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41801813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Gender-Responsive+Training%3A+Addressing+the+needs+of+incarcerated+women+and+girls&rft.au=Hoersch%2C+Michelle&rft.aulast=Hoersch&rft.aufirst=Michelle&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A health impact assessment of a rural county's General Plan density options T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41801772; 5069110 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Lindsay, Ann AU - Harris, Celia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Rural areas KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41801772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=A+health+impact+assessment+of+a+rural+county%27s+General+Plan+density+options&rft.au=Lindsay%2C+Ann%3BHarris%2C+Celia&rft.aulast=Lindsay&rft.aufirst=Ann&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health Communication: Integrating information technology and health literacy principles into Healthy People 2020 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41799746; 5065145 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Harris, Linda AU - Murray, Michelle AU - Baur, Cynthia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Information technology KW - Communication KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41799746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Health+Communication%3A+Integrating+information+technology+and+health+literacy+principles+into+Healthy+People+2020&rft.au=Harris%2C+Linda%3BMurray%2C+Michelle%3BBaur%2C+Cynthia&rft.aulast=Harris&rft.aufirst=Linda&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Town Hall Meetings: A Nationwide Underage Drinking Prevention Effort T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41797915; 5068842 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Ensley, Gwyndolyn Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Towns KW - Prevention KW - Drinking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41797915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Town+Hall+Meetings%3A+A+Nationwide+Underage+Drinking+Prevention+Effort&rft.au=Ensley%2C+Gwyndolyn&rft.aulast=Ensley&rft.aufirst=Gwyndolyn&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efforts at the U.S. Department of Health and Human Services (HHS) to prepare for and respond to increasing public health threats in a global society T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41794822; 5065247 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Chavez, Ilka Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41794822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Efforts+at+the+U.S.+Department+of+Health+and+Human+Services+%28HHS%29+to+prepare+for+and+respond+to+increasing+public+health+threats+in+a+global+society&rft.au=Chavez%2C+Ilka&rft.aulast=Chavez&rft.aufirst=Ilka&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Road to Health Initiative: A Creative Strategy to Increase Health Care Access to Underserved Latino Populations in Los Angeles County T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41793806; 5066232 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Alexander, Patricia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA, California, Los Angeles Cty. KW - Ethnic groups KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41793806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Road+to+Health+Initiative%3A+A+Creative+Strategy+to+Increase+Health+Care+Access+to+Underserved+Latino+Populations+in+Los+Angeles+County&rft.au=Alexander%2C+Patricia&rft.aulast=Alexander&rft.aufirst=Patricia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adults with disabilities: Quality and access to care T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41790853; 5067582 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Chevarley, Frances AU - Keer, David AU - Altman, Barbara AU - Moy, Ernest Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Disabilities KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41790853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Adults+with+disabilities%3A+Quality+and+access+to+care&rft.au=Chevarley%2C+Frances%3BKeer%2C+David%3BAltman%2C+Barbara%3BMoy%2C+Ernest&rft.aulast=Chevarley&rft.aufirst=Frances&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public health and the media: National newspaper coverage of minority health disparities T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41790157; 5065629 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Ghosh, Chandak Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41790157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Public+health+and+the+media%3A+National+newspaper+coverage+of+minority+health+disparities&rft.au=Ghosh%2C+Chandak&rft.aulast=Ghosh&rft.aufirst=Chandak&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Acculturation, Social Status, and Obesity-Related Risk Factors on Behavioral Problems among Children of Immigrant and US-born Parents T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41790103; 5067710 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Singh, Gopal AU - Kogan, Michael AU - Siahpush, Mohammad AU - Kenney, Mary Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Immigrants KW - Children KW - Social class KW - Social interactions KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41790103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Impact+of+Acculturation%2C+Social+Status%2C+and+Obesity-Related+Risk+Factors+on+Behavioral+Problems+among+Children+of+Immigrant+and+US-born+Parents&rft.au=Singh%2C+Gopal%3BKogan%2C+Michael%3BSiahpush%2C+Mohammad%3BKenney%2C+Mary&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Capacity building in Injury Prevention in a rural Navajo community T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41787249; 5065479 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Bill, Nancy AU - Begay, Mary Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Rural areas KW - Prevention KW - Injuries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41787249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Capacity+building+in+Injury+Prevention+in+a+rural+Navajo+community&rft.au=Bill%2C+Nancy%3BBegay%2C+Mary&rft.aulast=Bill&rft.aufirst=Nancy&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increase health promotion & disease prevention to underserved latino populations in T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41786361; 5066175 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Alexander, Patricia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Health promotion KW - Prevention KW - Ethnic groups KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41786361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Increase+health+promotion+%26amp%3B+disease+prevention+to+underserved+latino+populations+in&rft.au=Alexander%2C+Patricia&rft.aulast=Alexander&rft.aufirst=Patricia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Non-inferiority Trial Design Issues in Treatment-Experienced (TE) Patients with Active Optimized Background Regimens (OBR) T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40328149; 5260765 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Soon, G AU - Zhou, S AU - Qi, K. AU - Hammerstrom, T AU - Smith, F AU - Rhee, S AU - Naeger, L AU - Chan-Tack, K AU - Struble, K AU - Murray, J Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40328149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Non-inferiority+Trial+Design+Issues+in+Treatment-Experienced+%28TE%29+Patients+with+Active+Optimized+Background+Regimens+%28OBR%29&rft.au=Soon%2C+G%3BZhou%2C+S%3BQi%2C+K.%3BHammerstrom%2C+T%3BSmith%2C+F%3BRhee%2C+S%3BNaeger%2C+L%3BChan-Tack%2C+K%3BStruble%2C+K%3BMurray%2C+J&rft.aulast=Soon&rft.aufirst=G&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluating the Role of Anthrax Toxin in the Pathogenesis of B. anthracis T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40327833; 5260802 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Merkel, Tod Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Anthrax KW - Toxins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40327833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Evaluating+the+Role+of+Anthrax+Toxin+in+the+Pathogenesis+of+B.+anthracis&rft.au=Merkel%2C+Tod&rft.aulast=Merkel&rft.aufirst=Tod&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Moraxella catarrhalis Bacteremia in Children T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40321065; 5259234 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Crewalk, J AU - Pikis, A AU - Campos, J AU - Nambiar, S AU - Kadoorie, C AU - Jantausch, B Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Children KW - Bacteremia KW - Moraxella catarrhalis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40321065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Moraxella+catarrhalis+Bacteremia+in+Children&rft.au=Crewalk%2C+J%3BPikis%2C+A%3BCampos%2C+J%3BNambiar%2C+S%3BKadoorie%2C+C%3BJantausch%2C+B&rft.aulast=Crewalk&rft.aufirst=J&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post-Marketing (PM) Analysis of Vancomycin Associated Drug Rash, Eosinophilia, and Systemic Symptoms (DRESS) Syndrome T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40315986; 5259650 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Blank, J AU - Levorson, R AU - Nambiar, S Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Drugs KW - Eosinophilia KW - Exanthema KW - Side effects KW - Vancomycin KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40315986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Post-Marketing+%28PM%29+Analysis+of+Vancomycin+Associated+Drug+Rash%2C+Eosinophilia%2C+and+Systemic+Symptoms+%28DRESS%29+Syndrome&rft.au=Blank%2C+J%3BLevorson%2C+R%3BNambiar%2C+S&rft.aulast=Blank&rft.aufirst=J&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ongoing Concerns, New Laws, New Approaches- the FDA Perspective On Assessing Safety and Benefit of Rheumatology Treatments T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41899174; 5122023 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Seligman, Paul Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Ongoing+Concerns%2C+New+Laws%2C+New+Approaches-+the+FDA+Perspective+On+Assessing+Safety+and+Benefit+of+Rheumatology+Treatments&rft.au=Seligman%2C+Paul&rft.aulast=Seligman&rft.aufirst=Paul&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Why Oregon Went Wrong AN - 57261303; 200900014 AB - Oregon's brave plan to explicitly ration health care in order to cover more people soon ran into problems. Vidhya Alakeson looks at the reasons and asks whether history will repeat itself. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Alakeson, Vidhya AD - Department of Health and Human Services, Washington DC, USA alakesonvidhya@yahoo.co.uk Y1 - 2008/10/18/ PY - 2008 DA - 2008 Oct 18 SP - 900 EP - 901 PB - British Medical Association, BMJ Publishing Group, London UK VL - 337 IS - 7675 SN - 0959-535X, 0959-535X KW - Economics KW - Rationing KW - Health policy KW - Health services KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57261303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Why+Oregon+Went+Wrong&rft.au=Alakeson%2C+Vidhya&rft.aulast=Alakeson&rft.aufirst=Vidhya&rft.date=2008-10-18&rft.volume=337&rft.issue=7675&rft.spage=900&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-01-08 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Health services; Rationing; Health policy; Economics ER - TY - JOUR T1 - Possession, use, and transfer of select agents and toxins. Final rule. AN - 69819208; 19024787 AB - This document completes the biennial review and republication of the lists of biological agents and toxins regulated by the U.S. Department of Health and Human Services (HHS), as well as those biological agents and toxins regulated by both HHS and the U.S. Department of Agriculture (USDA). Because USDA has chosen to no longer regulate ten biological agents and toxins which HHS still believes have the potential to pose a severe threat to public health and safety, we have moved those ten biological agents and toxins from the overlap select agents and toxins section to the HHS select agents and toxins section of the select agent regulations. In a companion document published in this issue of the Federal Register, the USDA has established corresponding final rules regarding the select agents and toxins regulated only by the USDA, as well as those overlap select agents and toxins regulated by both agencies. JF - Federal register AU - Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS) AD - Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS) Y1 - 2008/10/16/ PY - 2008 DA - 2008 Oct 16 SP - 61363 EP - 61366 VL - 73 IS - 201 SN - 0097-6326, 0097-6326 KW - Biological Products KW - 0 KW - Neurotoxins KW - Toxins, Biological KW - Health technology assessment KW - United States KW - Bioterrorism -- legislation & jurisprudence KW - Humans KW - Bioterrorism -- prevention & control KW - United States Department of Agriculture -- legislation & jurisprudence KW - Government Regulation KW - United States Dept. of Health and Human Services -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69819208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Possession%2C+use%2C+and+transfer+of+select+agents+and+toxins.+Final+rule.&rft.au=Centers+for+Disease+Control+and+Prevention+%28CDC%29%2C+Department+of+Health+and+Human+Services+%28HHS%29&rft.aulast=Centers+for+Disease+Control+and+Prevention+%28CDC%29&rft.aufirst=Department+of+Health+and+Human+Services&rft.date=2008-10-16&rft.volume=73&rft.issue=201&rft.spage=61363&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-02 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli. AN - 69685556; 18771711 AB - In the present study, we characterized differential expressions of phosphorylated Ca(2+)/calmodulin-dependent protein kinase IIalpha (pCaMKIIalpha) and phosphorylated extracellular signal-regulated protein (pERK) in the mouse hippocampus induced by various nociceptive stimuli. In an immunoblot study, s.c. injection of formalin and intrathecal (i.t.) injections of glutamate, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1 beta) significantly increased pCaMKIIalpha expression in the hippocampus, but i.p. injections of acetic acid did not. pERK1/2 expression was also increased by i.t. injection of glutamate, TNF-alpha, and IL-1beta but not by s.c. injections of formalin or i.p. injections of acetic acid. In an immunohistochemical study, we found that increased pCaMKIIalpha and pERK expressions were mainly located at CA3 or the dentate gyrus of the hippocampus. In a behavioral study, we assessed the effects of PD98059 (a MEK 1/2 inhibitor) and KN-93 (a CaMKII inhibitor) following i.c.v. administration on the nociceptive behaviors induced by i.t. injections of glutamate, pro-inflammatory cytokines (TNF-alpha or IL-1beta), and i.p. injections of acetic acid. PD98059 as well as KN-93 significantly attenuated the nociceptive behavior induced by glutamate, pro-inflammatory cytokines, and acetic acid. Our results suggest that (1) pERKalpha and pCaMK-II located in the hippocampus are important regulators during the nociceptive processes induced by s.c. formalin, i.t. glutamate, i.t. pro-inflammatory cytokines, and i.p. acetic acid injection, respectively, and (2) the alteration of pERK and pCaMKIIalpha in nociceptive processing induced by formalin, glutamate, pro-inflammatory cytokines and acetic acid was modulated in a different manner. JF - Neuroscience AU - Seo, Y-J AU - Kwon, M-S AU - Choi, H-W AU - Choi, S-M AU - Kim, Y-W AU - Lee, J-K AU - Park, S-H AU - Jung, J-S AU - Suh, H-W AD - Division of Recombinant Product, Biopharmaceutical Bureau, Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul, 122-704, Republic of Korea. Y1 - 2008/10/15/ PY - 2008 DA - 2008 Oct 15 SP - 436 EP - 449 VL - 156 IS - 3 SN - 0306-4522, 0306-4522 KW - 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one KW - 0 KW - Benzylamines KW - Flavonoids KW - Interleukin-1beta KW - Protein Kinase Inhibitors KW - Sulfonamides KW - Tumor Necrosis Factor-alpha KW - KN 93 KW - 139298-40-1 KW - Formaldehyde KW - 1HG84L3525 KW - Glutamic Acid KW - 3KX376GY7L KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2 KW - EC 2.7.11.17 KW - Camk2a protein, mouse KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Acetic Acid KW - Q40Q9N063P KW - Index Medicus KW - Benzylamines -- pharmacology KW - Animals KW - Mice, Inbred ICR KW - Analysis of Variance KW - Protein Kinase Inhibitors -- pharmacology KW - Pain Measurement -- methods KW - Mice KW - Behavior, Animal KW - Phosphorylation KW - Sulfonamides -- pharmacology KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Flavonoids -- pharmacology KW - Time Factors KW - Male KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2 -- metabolism KW - Pain -- chemically induced KW - Hippocampus -- enzymology KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Pain -- metabolism KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69685556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Differential+expression+of+phosphorylated+Ca2%2B%2Fcalmodulin-dependent+protein+kinase+II+and+phosphorylated+extracellular+signal-regulated+protein+in+the+mouse+hippocampus+induced+by+various+nociceptive+stimuli.&rft.au=Seo%2C+Y-J%3BKwon%2C+M-S%3BChoi%2C+H-W%3BChoi%2C+S-M%3BKim%2C+Y-W%3BLee%2C+J-K%3BPark%2C+S-H%3BJung%2C+J-S%3BSuh%2C+H-W&rft.aulast=Seo&rft.aufirst=Y-J&rft.date=2008-10-15&rft.volume=156&rft.issue=3&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2008.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-14 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2008.08.002 ER - TY - CPAPER T1 - Immunotherapy with CpG Oligonucleotides and Antibodies to TNF? Rescue Neonatal Mice from Lethal Arena Virus-induced Meningoencephalitis. T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42061620; 4976147 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Pedras-Vasconcelos, Joao A AU - Puig, Montserrat AU - Sauder, Christian AU - Wolbert, Candie AU - Ovanesov, Mikhail AU - Verthelyi, Daniela Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Immunotherapy KW - Mice KW - Neonates KW - Tumor necrosis factor KW - Antibodies KW - Oligonucleotides KW - Meningoencephalitis KW - CpG islands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42061620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Immunotherapy+with+CpG+Oligonucleotides+and+Antibodies+to+TNF%3F+Rescue+Neonatal+Mice+from+Lethal+Arena+Virus-induced+Meningoencephalitis.&rft.au=Pedras-Vasconcelos%2C+Joao+A%3BPuig%2C+Montserrat%3BSauder%2C+Christian%3BWolbert%2C+Candie%3BOvanesov%2C+Mikhail%3BVerthelyi%2C+Daniela&rft.aulast=Pedras-Vasconcelos&rft.aufirst=Joao&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coalbed Discontinuity Effects on the Production of Degasification Boreholes and on Emissions During Longwall Mining T2 - 2008 Society of Petroleum Engineers Eastern Regional and AAPG Eastern Section Joint Meeting AN - 41103759; 4951983 JF - 2008 Society of Petroleum Engineers Eastern Regional and AAPG Eastern Section Joint Meeting AU - Karacan, C O AU - Goodman, G Y1 - 2008/10/11/ PY - 2008 DA - 2008 Oct 11 KW - Boreholes KW - Mining KW - Emissions KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41103759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Society+of+Petroleum+Engineers+Eastern+Regional+and+AAPG+Eastern+Section+Joint+Meeting&rft.atitle=Coalbed+Discontinuity+Effects+on+the+Production+of+Degasification+Boreholes+and+on+Emissions+During+Longwall+Mining&rft.au=Karacan%2C+C+O%3BGoodman%2C+G&rft.aulast=Karacan&rft.aufirst=C&rft.date=2008-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Society+of+Petroleum+Engineers+Eastern+Regional+and+AAPG+Eastern+Section+Joint+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.aapgspe2008.org/p12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats. AN - 69497311; 18682277 AB - Neurochemical studies suggest that baclofen, an agonist at GABA(B) receptors, may be useful for treatment of nicotine dependence. However, its ability to selectively reduce nicotine's abuse-related behavioral effects remains in question. We assessed effects of baclofen doses ranging from 0.1 to 3mg/kg on nicotine-induced conditioned place preferences (CPPs), nicotine discrimination, locomotor activity and food-reinforced behavior in male Sprague-Dawley rats. The high dose of baclofen (3mg/kg) totally eliminated food-reinforced responding and significantly decreased locomotor activity. Lower doses of baclofen did not have nicotine-like discriminative effects in rats trained to discriminate 0.4mg/kg nicotine from saline under a fixed-ratio 10 schedule of food delivery. Lower doses of baclofen also did not reduce discriminative stimulus effects of the training dose of nicotine and did not significantly shift the dose-response curve for nicotine discrimination. Rats treated with the high 3mg/kg dose of baclofen did not express nicotine-induced CPP. These experiments, along with previous reports that baclofen can reduce intravenous nicotine self-administration behavior, confirm the potential utility of baclofen as a tool for smoking cessation. JF - Neuroscience letters AU - Le Foll, Bernard AU - Wertheim, Carrie E AU - Goldberg, Steven R AD - National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA. bernard_lefoll@camh.net Y1 - 2008/10/10/ PY - 2008 DA - 2008 Oct 10 SP - 236 EP - 240 VL - 443 IS - 3 SN - 0304-3940, 0304-3940 KW - GABA Agonists KW - 0 KW - Nicotinic Agonists KW - Nicotine KW - 6M3C89ZY6R KW - Baclofen KW - H789N3FKE8 KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Reinforcement Schedule KW - Dose-Response Relationship, Drug KW - Motor Activity -- drug effects KW - Male KW - Conditioning, Operant -- drug effects KW - Discrimination (Psychology) -- drug effects KW - GABA Agonists -- pharmacology KW - Reward KW - Discrimination (Psychology) -- physiology KW - Conditioning, Operant -- physiology KW - Nicotine -- pharmacology KW - Nicotinic Agonists -- pharmacology KW - Baclofen -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69497311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Effects+of+baclofen+on+conditioned+rewarding+and+discriminative+stimulus+effects+of+nicotine+in+rats.&rft.au=Le+Foll%2C+Bernard%3BWertheim%2C+Carrie+E%3BGoldberg%2C+Steven+R&rft.aulast=Le+Foll&rft.aufirst=Bernard&rft.date=2008-10-10&rft.volume=443&rft.issue=3&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/10.1016%2Fj.neulet.2008.07.074 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-03 N1 - Date created - 2008-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 2003 Jun;167(4):335-43 [12684733] Neuroscience. 2003;118(1):123-34 [12676144] Psychopharmacology (Berl). 2004 Mar;172(2):179-86 [14610636] Neuroreport. 2004 Sep 15;15(13):2139-43 [15486497] J Neurochem. 1977 Nov;29(5):797-802 [591956] J Consult Clin Psychol. 1982 Feb;50(1):71-86 [7056922] Psychopharmacology (Berl). 1983;81(1):54-60 [6415731] Psychopharmacology (Berl). 1984;84(3):413-9 [6440189] Pharmacol Biochem Behav. 1985 Feb;22(2):237-41 [2858867] Br J Pharmacol. 1987 Jan;90(1):239-46 [2880625] Eur J Pharmacol. 1986 Dec 16;132(2-3):337-8 [3816984] Trends Pharmacol Sci. 1992 May;13(5):177-84 [1604710] Pharmacol Biochem Behav. 1994 Jul;48(3):817-20 [7938142] Nature. 1996 Jul 18;382(6588):255-7 [8717040] Neuropsychopharmacology. 1996 Oct;15(4):417-23 [8887996] BMJ. 1997 Jan 18;314(7075):180-1 [9022432] Psychopharmacology (Berl). 1997 Feb;129(4):390-7 [9085409] Psychopharmacology (Berl). 1997 Jun;131(3):271-7 [9203238] Nature. 1997 Nov 27;390(6658):401-4 [9389479] Behav Pharmacol. 1998 May;9(3):195-206 [9832934] Synapse. 1999 Jan;31(1):76-86 [10025686] J Pharmacol Exp Ther. 1999 Mar;288(3):1053-73 [10027843] Psychopharmacology (Berl). 1999 Apr;143(2):209-14 [10326784] J Pharmacol Exp Ther. 1999 Sep;290(3):1369-74 [10454516] Ann N Y Acad Sci. 2004 Oct;1025:491-503 [15542754] Neuropsychopharmacology. 2005 Jan;30(1):119-28 [15266350] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Psychopharmacology (Berl). 2005 Apr;178(4):481-92 [15765262] Neuropsychopharmacology. 2005 Apr;30(4):720-30 [15562293] Psychopharmacology (Berl). 2006 Mar;184(3-4):367-81 [16205918] Lancet. 2007 Dec 8;370(9603):1915-22 [18068515] Addict Biol. 2008 Jun;13(2):239-52 [18482433] Life Sci. 2000 Feb 18;66(13):PL169-73 [10737423] Psychopharmacology (Berl). 2000 Feb;148(3):314-21 [10755745] Nicotine Tob Res. 2001 May;3(2):123-9 [11403726] Pharmacol Biochem Behav. 2001 Dec;70(4):515-30 [11796151] Drug Alcohol Depend. 2002 Feb 1;65(3):209-20 [11841892] Synapse. 2002 May;44(2):61-3 [11891877] Neuropharmacology. 2002 Mar;42(4):530-9 [11955523] Life Sci. 2001 Dec 7;70(3):349-56 [12005267] Synapse. 2002 Jun 15;44(4):252-3 [11984860] Alcohol Alcohol. 2002 Sep-Oct;37(5):478-84 [12217943] Alcohol Alcohol. 2002 Sep-Oct;37(5):495-8 [12217945] Behav Pharmacol. 2002 Sep;13(5-6):451-63 [12394421] Mol Psychiatry. 2003 Feb;8(2):225-30 [12610655] Neuropsychopharmacology. 2003 Mar;28(3):510-8 [12629530] Synapse. 2003 Oct;50(1):1-6 [12872287] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neulet.2008.07.074 ER - TY - CPAPER T1 - New aspects of COPD ethiopathogenesis T2 - 2008 Annual Congress of the European Respiratory Society AN - 41121931; 4962935 JF - 2008 Annual Congress of the European Respiratory Society AU - Kobylyansky, Viacheslav AU - Ivanov, Igor AU - Gamal, Evgeniy AU - Babadzhanova, Gulnara AU - Petrova, Tatyana Y1 - 2008/10/04/ PY - 2008 DA - 2008 Oct 04 KW - Chronic obstructive pulmonary disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41121931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Congress+of+the+European+Respiratory+Society&rft.atitle=New+aspects+of+COPD+ethiopathogenesis&rft.au=Kobylyansky%2C+Viacheslav%3BIvanov%2C+Igor%3BGamal%2C+Evgeniy%3BBabadzhanova%2C+Gulnara%3BPetrova%2C+Tatyana&rft.aulast=Kobylyansky&rft.aufirst=Viacheslav&rft.date=2008-10-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Congress+of+the+European+Respiratory+Society&rft.issn=&rft_id=info:doi/ L2 - http://dev.ersnet.org/413-scientific-programme.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Renal Papillary Antigen-1 (RPA-1) Cross-Reactivity in Necrotic Renal Proximal Tubules: Significance of Immunohistochemistry and Histopathology AN - 877589009; 13617802 JF - Toxicologic Pathology AU - Zhang, Jun AU - Shaw, Martin AU - Goering, Peter L AD - Center for Drug Evaluation and Research, FDA Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 891 EP - 893 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 36 IS - 6 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877589009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Renal+Papillary+Antigen-1+%28RPA-1%29+Cross-Reactivity+in+Necrotic+Renal+Proximal+Tubules%3A+Significance+of+Immunohistochemistry+and+Histopathology&rft.au=Zhang%2C+Jun%3BShaw%2C+Martin%3BGoering%2C+Peter+L&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2008-10-01&rft.volume=36&rft.issue=6&rft.spage=891&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623308324960 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 4 N1 - Last updated - 2012-06-18 DO - http://dx.doi.org/10.1177/0192623308324960 ER - TY - JOUR T1 - Comparison of Web-Based versus Paper-and-Pencil Self-Administered Questionnaire: Effects on Health Indicators in Dutch Adolescents AN - 839582133; 201104335 AB - Objective. The aim of this study is to investigate differences in responses related to (mental) health and behavior between two methods of data collection: web-based (web) and paper-and-pencil (p&p). Study Design. Within each participating school all third-grade classes (mainly 14-15-year-old pupils) were randomly assigned to either the Internet condition (n=271) or the paper-and-pencil condition (n=261). Principal Findings. Significant but small differences were found for the strengths and difficulties subscales "emotional symptoms" (p&p>web) and "prosocial behavior" (p&p>web), and carrying a weapon (web>p&p). Perceived level of privacy and confidentiality did not differ between the two modes. Conclusions. The findings suggest that in a controlled school setting, web-based administration of health indicators yields almost the same results as paper-and-pencil administration. To generalize these findings, we recommend repeated studies in other populations and settings. Adapted from the source document. JF - Health Services Research AU - van de Looij-Jansen, Petra M. AU - de Wilde, Erik Jan AD - Youth Department, Municipal Public Health Service for the Rotterdam Area, PO Box 70032, 3000 LP Rotterdam, The Netherlands Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1708 EP - 1721 PB - Blackwell Publishers, Oxford UK VL - 43 IS - 5p1 SN - 0017-9124, 0017-9124 KW - Methodology computerized questionnaire preventive youth health care adolescents SDQ KW - Symptoms KW - Prosocial behaviour KW - Health indicators KW - Confidentiality KW - Computer based KW - Internet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839582133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Comparison+of+Web-Based+versus+Paper-and-Pencil+Self-Administered+Questionnaire%3A+Effects+on+Health+Indicators+in+Dutch+Adolescents&rft.au=van+de+Looij-Jansen%2C+Petra+M.%3Bde+Wilde%2C+Erik+Jan&rft.aulast=van+de+Looij-Jansen&rft.aufirst=Petra&rft.date=2008-10-01&rft.volume=43&rft.issue=5p1&rft.spage=1708&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2008.00860.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Internet; Computer based; Health indicators; Prosocial behaviour; Confidentiality; Symptoms DO - http://dx.doi.org/10.1111/j.1475-6773.2008.00860.x ER - TY - JOUR T1 - Hospital Quality, Efficiency, and Input Slack Differentials AN - 839581733; 201104324 AB - Objective. To use an advance in data envelopment analysis (DEA) called congestion analysis to assess the trade-offs between quality and efficiency in U.S. hospitals. Study Setting. Urban U.S. hospitals in 34 states operating in 2004. Study Design and Data Collection. Input and output data from 1,377 urban hospitals were taken from the American Hospital Association Annual Survey and the Medicare Cost Reports. Nurse-sensitive measures of quality came from the application of the Patient Safety Indicator (PSI) module of the Agency for Healthcare Research and Quality (AHRQ) Quality Indicator software to State Inpatient Databases (SID) provided by the Healthcare Cost and Utilization Project (HCUP). Data Analysis. In the first step of the study, hospitals' relative output-based efficiency was determined in order to obtain a measure of congestion (i.e., the productivity loss due to the occurrence of patient safety events). The outputs were adjusted to account for this productivity loss, and a second DEA was performed to obtain input slack values. Differences in slack values between unadjusted and adjusted outputs were used to measure either relative inefficiency or a need for quality improvement. Principal Findings. Overall, the hospitals in our sample could increase the total amount of outputs produced by an average of 26 percent by eliminating inefficiency. About 3 percent of this inefficiency can be attributed to congestion. Analysis of subsamples showed that teaching hospitals experienced no congestion loss. We found that quality of care could be improved by increasing the number of labor inputs in low-quality hospitals, whereas high-quality hospitals tended to have slack on personnel. Conclusions. Results suggest that reallocation of resources could increase the relative quality among hospitals in our sample. Further, higher quality in some dimensions of care need not be achieved as a result of higher costs or through reduced access to health care. Adapted from the source document. JF - Health Services Research AU - Valdmanis, Vivian G AU - Rosko, Michael D AU - Mutter, Ryan L AD - Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, 540 Gaither Road, Rockville, MD 20850 Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1830 EP - 1848 PB - Blackwell Publishers, Oxford UK VL - 43 IS - 5p2 SN - 0017-9124, 0017-9124 KW - Hospital efficiency data envelopment analysis congestion patient safety nurse-sensitive outcomes KW - Quality of care KW - Health care KW - Productivity KW - Patient care KW - Congestion KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839581733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Hospital+Quality%2C+Efficiency%2C+and+Input+Slack+Differentials&rft.au=Valdmanis%2C+Vivian+G%3BRosko%2C+Michael+D%3BMutter%2C+Ryan+L&rft.aulast=Valdmanis&rft.aufirst=Vivian&rft.date=2008-10-01&rft.volume=43&rft.issue=5p2&rft.spage=1830&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2008.00893.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Hospitals; Quality of care; Congestion; Patient care; Health care; Productivity DO - http://dx.doi.org/10.1111/j.1475-6773.2008.00893.x ER - TY - JOUR T1 - Ozone and Other Air Pollutants and the Risk of Oral Clefts AN - 743580412; 201004-31-0304787 (CE); 12103981 (EN) AB - BACKGROUND: Air pollution influences the development of oral clefts in animals. There are few epidemiologic data on the relation of prenatal air pollution exposure and the risk of oral clefts. OBJECTIVES: Our goal in this study was to assess the relations between exposure to ambient air pollution and the risk of cleft lip with or without cleft palate (CL/P). METHODS: We conducted a population-based case-control study of all 653 cases of CL/P and a random sample of 6,530 control subjects from 721,289 Taiwanese newborns in 2001-2003. We used geographic information systems to form exposure parameters for sulfur dioxide, nitrogen oxides, ozone, carbon monoxide, and particulate matter with an aerodynamic diameter or= 10 microm (PM10) during the first 3 months of pregnancy using inverse distance weighting method. We present the effect estimates as odds ratios (ORs) per 10-ppb change for SO2, NO(x), and O3, 100-ppb change for CO, and 10-microg/m3 change for PM10. RESULTS: The risk of CL/P was increased in relation to O3 levels in the first gestational month [adjusted OR = 1.20; 95% confidence interval (CI), 1.02-1.39] and second gestational month (adjusted OR = 1.25; 95% CI, 1.03-1.52) in the range from 16.7 ppb to 45.1 ppb, but was not related to CO, NO(x), SO2, or PM10. CONCLUSIONS: The study provides new evidence that exposure to outdoor air O3 during the first and second month of pregnancy may increase the risk of CL/P. Similar levels of O3 are encountered globally by large numbers of pregnant women. JF - Environmental Health Perspectives AU - Hwang, Bing-Fang AU - Jaakkola, Jouni J K PY - 2008 SP - 1411 EP - 1415 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Air pollution KW - Carbon monoxide KW - Pregnancy KW - Health KW - Ozone KW - Adjustment KW - Geographic information systems KW - Epidemiology KW - Estimates KW - Nitrogen oxides KW - Confidence intervals KW - Sulfur dioxide KW - Satellite navigation systems KW - Weighting methods KW - Copyrights KW - Inverse KW - Animals KW - Pollutants KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743580412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Ozone+and+Other+Air+Pollutants+and+the+Risk+of+Oral+Clefts&rft.au=Hwang%2C+Bing-Fang%3BJaakkola%2C+Jouni+J+K&rft.aulast=Hwang&rft.aufirst=Bing-Fang&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Exposure of Neonatal Rats to Parathion Elicits Sex-Selective Impairment of Acetylcholine Systems in Brain Regions during Adolescence and Adulthood AN - 743577496; 201004-31-0304803 (CE); 12103997 (EN) AB - BACKGROUND: Organophosphates elicit developmental neurotoxicity through multiple mechanisms other than their shared property as cholinesterase inhibitors. Accordingly, these agents may differ in their effects on specific brain circuits. OBJECTIVES: We gave parathion to neonatal rats [postnatal days (PNDs) 1-4], at daily doses of 0.1 or 0.2 mg/kg, spanning the threshold for barely detectable cholinesterase inhibition and systemic effects. METHODS: We assessed neurochemical indices related to the function of acetylcholine (ACh) synapses (choline acetyltransferase, presynaptic high-affinity choline transporter, nicotinic cholinergic receptors) in brain regions comprising all the major ACh projections, with determinations carried out from adolescence to adulthood (PNDs 30, 60, and 100). RESULTS: Parathion exposure elicited lasting alterations in ACh markers in the frontal/parietal cortex, temporal/occipital cortex, midbrain, hippocampus, and striatum. In cerebrocortical areas, midbrain, and hippocampus, effects in males were generally greater than in females, whereas in the striatum, females were targeted preferentially. Superimposed on this general pattern, the cerebrocortical effects showed a nonmonotonic dose-response relationship, with regression of the defects at the higher parathion dose; this relationship has been seen also after comparable treatments with chlorpyrifos and diazinon and likely represents the involvement of cholinesterase-related actions that mask or offset the effects of lower doses. CONCLUSIONS: Neonatal exposure to parathion, at doses straddling the threshold for cholinesterase inhibition, compromises indices of ACh synaptic function in adolescence and adulthood. Differences between the effects of parathion compared with chlorpyrifos or diazinon and the non-monotonic dose-effect relationships reinforce the conclusion that various organophosphates diverge in their effects on neurodevelopment, unrelated to their anticholinesterase actions. JF - Environmental Health Perspectives AU - Slotkin, Theodore A AU - Bodwell, Bethany E AU - Ryde, Ian T AU - Levin, Edward D AU - Seidler, Frederic J PY - 2008 SP - 1308 EP - 1314 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Inhibitors KW - Brain KW - Cholinesterase KW - Chlorpyrifos KW - Choline KW - Health KW - Thresholds KW - Inhibition KW - Organophosphates KW - Females KW - Hippocampus KW - Cortexes KW - Rats KW - Transporter KW - Regression KW - Impairment KW - Cholinergics KW - Synapses KW - Markers KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743577496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+of+Neonatal+Rats+to+Parathion+Elicits+Sex-Selective+Impairment+of+Acetylcholine+Systems+in+Brain+Regions+during+Adolescence+and+Adulthood&rft.au=Slotkin%2C+Theodore+A%3BBodwell%2C+Bethany+E%3BRyde%2C+Ian+T%3BLevin%2C+Edward+D%3BSeidler%2C+Frederic+J&rft.aulast=Slotkin&rft.aufirst=Theodore&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1308&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Traffic-Related Air Pollution and Asthma Onset in Children: A Prospective Cohort Study with Individual Exposure Measurement AN - 743541817; 201004-31-0304794 (CE); 12103988 (EN) AB - BACKGROUND: The question of whether air pollution contributes to asthma onset remains unresolved. OBJECTIVES: In this study, we assessed the association between asthma onset in children and traffic-related air pollution. METHODS: We selected a sample of 217 children from participants in the Southern California Children's Health Study, a prospective cohort designed to investigate associations between air pollution and respiratory health in children 10-18 years of age. Individual covariates and new asthma incidence (30 cases) were reported annually through questionnaires during 8 years of follow-up. Children had nitrogen dioxide monitors placed outside their home for 2 weeks in the summer and 2 weeks in the fall-winter season as a marker of traffic-related air pollution. We used multilevel Cox models to test the associations between asthma and air pollution. RESULTS: In models controlling for confounders, incident asthma was positively associated with traffic pollution, with a hazard ratio (HR) of 1.29 [95% confidence interval (CI), 1.07-1.56] across the average within-community interquartile range of 6.2 ppb in annual residential NO2. Using the total interquartile range for all measurements of 28.9 ppb increased the HR to 3.25 (95% CI, 1.35-7.85). CONCLUSIONS: In this cohort, markers of traffic-related air pollution were associated with the onset of asthma. The risks observed suggest that air pollution exposure contributes to new-onset asthma. JF - Environmental Health Perspectives AU - Jerrett, Michael AU - Shankardass, Ketan AU - Berhane, Kiros AU - Gauderman, W James AU - Kuenzli, Nino AU - Avol, Edward AU - Gilliland, Frank AU - Lurmann, Fred AU - Molitor, Jassy N AU - Molitor, John T AU - Thomas, Duncan C AU - Peters, John AU - McConnell, Rob PY - 2008 SP - 1433 EP - 1438 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Air pollution KW - Asthma KW - Children KW - Health KW - Nitrogen dioxide KW - Markers KW - Monitors KW - Risk KW - Traffic flow KW - Southern California KW - Traffic engineering KW - Seasons KW - Mathematical models KW - Confidence intervals KW - Hazards KW - Multilevel KW - Incidence KW - Copyrights KW - Summer KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743541817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Traffic-Related+Air+Pollution+and+Asthma+Onset+in+Children%3A+A+Prospective+Cohort+Study+with+Individual+Exposure+Measurement&rft.au=Jerrett%2C+Michael%3BShankardass%2C+Ketan%3BBerhane%2C+Kiros%3BGauderman%2C+W+James%3BKuenzli%2C+Nino%3BAvol%2C+Edward%3BGilliland%2C+Frank%3BLurmann%2C+Fred%3BMolitor%2C+Jassy+N%3BMolitor%2C+John+T%3BThomas%2C+Duncan+C%3BPeters%2C+John%3BMcConnell%2C+Rob&rft.aulast=Jerrett&rft.aufirst=Michael&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1433&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Relationship between Prenatal PCB Exposure and Intelligence (IQ) in 9-Year-Old Children AN - 743515030; 201004-31-0304786 (CE); 12103980 (EN) AB - BACKGROUND: Several epidemiologic studies have demonstrated relationships between prenatal exposure to polychlorinated biphenyls (PCBs) and modest cognitive impairments in infancy and early childhood. However, few studies have followed cohorts of exposed children long enough to examine the possible impact of prenatal PCB exposure on psychometric intelligence in later childhood. Of the few studies that have done so, one in the Great Lakes region of the United States reported impaired IQ in children prenatally exposed to PCBs, whereas another found no association. OBJECTIVES: This study was designed to determine whether environmental exposure to PCBs predicts lower IQ in school-age children in the Great Lakes region of the northeastern United States. METHODS: We measured prenatal exposure to PCBs and IQ at 9 years of age in 156 subjects from Oswego, New York. We also measured 50 potential predictors of intelligence in children, including repeated measures of the home environment [Home Observation for Measurement of the Environment (HOME)], socioeconomic status (SES), parental IQ, alcohol/cigarette use, neonatal risk factors, and nutrition. RESULTS: For each 1-ng/g (wet weight) increase in PCBs in placental tissue, Full Scale IQ dropped by three points (p = 0.02), and Verbal IQ dropped by four points (p = 0.003). The median PCB level was 1.50 ng/g, with a lower quartile of 1.00 ng/g and an upper quartile of 2.06 ng/g. Moreover, this association was significant after controlling for many potential confounders, including prenatal exposure to methylmercury, dichlorodiphenyldichloroethylene, hexachlorobenzene, and lead. CONCLUSIONS: These results, in combination with similar results obtained from a similar study in the Great Lakes conducted 10 years earlier, indicate that prenatal PCB exposure in the Great Lakes region is associated with lower IQ in children. JF - Environmental Health Perspectives AU - Stewart, Paul W AU - Lonky, Edward AU - Reihman, Jacqueline AU - Pagano, James AU - Gump, Brooks B AU - Darvill, Thomas PY - 2008 SP - 1416 EP - 1422 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Circuit boards KW - Lakes KW - Printed circuits KW - Intelligence KW - Health KW - Ecological risk assessment KW - Quartiles KW - Exposure KW - Nutrition KW - Risk KW - Psychometrics KW - Impairment KW - Epidemiology KW - Alcohols KW - Cigarettes KW - Copyrights KW - Polychlorinated biphenyls KW - Hexachlorobenzene KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743515030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Relationship+between+Prenatal+PCB+Exposure+and+Intelligence+%28IQ%29+in+9-Year-Old+Children&rft.au=Stewart%2C+Paul+W%3BLonky%2C+Edward%3BReihman%2C+Jacqueline%3BPagano%2C+James%3BGump%2C+Brooks+B%3BDarvill%2C+Thomas&rft.aulast=Stewart&rft.aufirst=Paul&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1416&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Effect of Heat Waves on Mental Health in a Temperate Australian City AN - 743511911; 201004-31-0304796 (CE); 12103990 (EN) AB - OBJECTIVE: The goal of this study was to identify mental, behavioral, and cognitive disorders that may be triggered or exacerbated during heat waves, predisposing individuals to heat-related morbidity and mortality. DESIGN: Using health outcome data from Adelaide, South Australia, for 1993-2006, we estimated the effect of heat waves on hospital admissions and mortalities attributed to mental, behavioral, and cognitive disorders. We analyzed data using Poisson regression accounting for overdispersion and controlling for season and long-term trend, and we performed threshold analysis using hockey stick regression. RESULTS: Above a threshold of 26.7 degrees C, we observed a positive association between ambient temperature and hospital admissions for mental and behavioral disorders. Compared with non-heat-wave periods, hospital admissions increased by 7.3% during heat waves. Specific illnesses for which admissions increased included organic illnesses, including symptomatic mental disorders; dementia; mood (affective) disorders; neurotic, stress related, and somatoform disorders; disorders of psychological development; and senility. Mortalities attributed to mental and behavioral disorders increased during heat waves in the 65- to 74-year age group and in persons with schizophrenia, schizotypal, and delusional disorders. Dementia deaths increased in those up to 65 years of age. CONCLUSION: Our results suggest that episodes of extreme heat pose a salient risk to the health and well-being of the mentally ill. RELEVANCE TO CLINICAL OR PROFESSIONAL PRACTICE: Improvements in the management and care of the mentally ill need to be addressed to avoid an increase in psychiatric morbidity and mortality as heat waves become more frequent. JF - Environmental Health Perspectives AU - Hansen, Alana AU - Bi, Peng AU - Nitschke, Monika AU - Ryan, Philip AU - Pisaniello, Dino AU - Tucker, Graeme PY - 2008 SP - 1369 EP - 1375 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Disorders KW - Mortality KW - Health KW - Hospitals KW - Regression KW - Thresholds KW - Illnesses KW - Age KW - Moods KW - Risk KW - Schizophrenia KW - Regression analysis KW - Seasons KW - Mental health KW - Copyrights KW - Design engineering KW - Ambient temperature KW - Management KW - Mental disorders KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743511911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Effect+of+Heat+Waves+on+Mental+Health+in+a+Temperate+Australian+City&rft.au=Hansen%2C+Alana%3BBi%2C+Peng%3BNitschke%2C+Monika%3BRyan%2C+Philip%3BPisaniello%2C+Dino%3BTucker%2C+Graeme&rft.aulast=Hansen&rft.aufirst=Alana&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1369&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Influence of Living Near Roadways on Spirometry and Exhaled Nitric Oxide in Elementary Schoolchildren AN - 743509552; 201004-31-0304788 (CE); 12103982 (EN) AB - BACKGROUND: Living near major roadways has been associated with an increase in respiratory symptoms, but little is known about how this relates to airway inflammation. OBJECTIVE: We assessed the effects of living near local residential roadways based on objective indicators of ventilatory function and airway inflammation. METHODS: We estimated ambient air pollution, resolved to the level of the child's neighborhood, using a land-use regression model for children 9-11 years of age. We also summed the length of roadways found within a 200-m radius of each child's neighborhood. We had measurements of both air pollution exposure and spirometry for 2,328 children, and also had measurements of exhaled nitric oxide (eNO) for 1,613 of these children. RESULTS: Each kilometer of local roadway within a 200-m radius of the home was associated with a 6.8% increase in eNO (p = 0.045). Each kilometer of any type of roadway (local, major, highway) was also associated with an increase in eNO of 10.1% (p = 0.002). Each microgram per cubic meter increase in PM2.5 was associated with a 3.9% increase in eNO (p = 0.058) and 0.70% decrease in forced vital capacity (FVC) expressed as a percentage of predicted (p = 0.39). Associations between roadway density and both forced expired volume in 1 sec and FVC were negative but not statistically significant at p 0.05. CONCLUSION: Traffic from local neighborhood roadways may cause airway inflammation as indicated by eNO. This may be a more sensitive indicator of adverse air pollution effects than traditional measures of ventilatory function. JF - Environmental Health Perspectives AU - Dales, Robert AU - Wheeler, Amanda AU - Mahmud, Mamun AU - Frescura, Anna Maria AU - Smith-Doiron, Marc AU - Nethery, Elizabeth AU - Liu, Ling PY - 2008 SP - 1423 EP - 1427 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Roadways KW - Mathematical models KW - Air pollution KW - Children KW - Airways KW - Indicators KW - Health KW - Density KW - Nitric oxide KW - Highways KW - Meters KW - Regression KW - Traffic flow KW - Land use KW - Traffic engineering KW - Measuring instruments KW - Copyrights KW - Maria KW - Age KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743509552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Influence+of+Living+Near+Roadways+on+Spirometry+and+Exhaled+Nitric+Oxide+in+Elementary+Schoolchildren&rft.au=Dales%2C+Robert%3BWheeler%2C+Amanda%3BMahmud%2C+Mamun%3BFrescura%2C+Anna+Maria%3BSmith-Doiron%2C+Marc%3BNethery%2C+Elizabeth%3BLiu%2C+Ling&rft.aulast=Dales&rft.aufirst=Robert&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1423&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Association between Traffic-Related Black Carbon Exposure and Lung Function among Urban Women AN - 743473855; 201004-31-0304800 (CE); 12103994 (EN) AB - BACKGROUND: Although a number of studies have documented the relationship between lung function and traffic-related pollution among children, few have focused on adult lung function or examined community-based populations. OBJECTIVE: We examined the relationship between black carbon (BC), a surrogate of traffic-related particles, and lung function among women in the Maternal-Infant Smoking Study of East Boston, an urban cohort in Boston, Massachusetts. METHODS: We estimated local BC levels using a validated spatiotemporal land-use regression model, derived using ambient and indoor monitor data. We examined associations between percent predicted pulmonary function and predicted BC using linear regression, adjusting for sociodemographics (individual and neighborhood levels), smoking status, occupational exposure, type of cooking fuel, and a diagnosis of asthma or chronic bronchitis. RESULTS: The sample of 272 women 18-42 years of age included 57% who self-identified as Hispanic versus 43% white, and 18% who were current smokers. Mean +/- SD predicted annual BC exposure level was 0.62 +/- 0.2 microg/m3. In adjusted analysis, BC (per interquartile range increase) was associated with a 1.1% decrease [95% confidence interval (CI), -2.5% to 0.3%] in forced expiratory volume in 1 sec, a 0.6% decrease (95% CI, -1.9% to 0.6%) in forced vital capacity, and a 3.0% decrease (95% CI, -5.8% to -0.2%) in forced mid-expiratory flow rate. We noted differential effects by smoking status in that former smokers were most affected by BC exposure, whereas current smokers were not affected. CONCLUSION: In this cohort, exposure to traffic-related BC, a component of particulate matter, independently predicted decreased lung function in urban women, when adjusting for tobacco smoke, asthma diagnosis, and socioeconomic status. JF - Environmental Health Perspectives AU - Suglia, Shakira Franco AU - Gryparis, Alexandros AU - Schwartz, Joel AU - Wright, Rosalind J PY - 2008 SP - 1333 EP - 1337 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Lungs KW - Smoking KW - Carbon KW - Asthma KW - Regression KW - Diagnosis KW - Health KW - Cooking KW - Smoke KW - Monitors KW - Heating KW - Adults KW - Children KW - Flow rate KW - Indoor KW - Populations KW - Land use KW - Occupational KW - Article KW - EE 70:Energy (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743473855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Association+between+Traffic-Related+Black+Carbon+Exposure+and+Lung+Function+among+Urban+Women&rft.au=Suglia%2C+Shakira+Franco%3BGryparis%2C+Alexandros%3BSchwartz%2C+Joel%3BWright%2C+Rosalind+J&rft.aulast=Suglia&rft.aufirst=Shakira&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Respiratory and Other Health Effects Reported in Children Exposed to the World Trade Center Disaster of 11 September 2001 AN - 743427811; 201004-31-0304790 (CE); 12103984 (EN) AB - BACKGROUND: Effects of the World Trade Center (WTC) disaster on children's respiratory health have not been definitively established. OBJECTIVE: This report describes respiratory health findings among children who were 18 years of age on 11 September 2001 (9/11) and examine associations between disaster-related exposures and respiratory health. METHODS: Children recruited for the WTC Health Registry (WTCHR) included child residents and students (kindergarten through 12th grade) in Manhattan south of Canal Street, children who were south of Chambers Street on 9/11, and adolescent disaster-related workers or volunteers. We collected data via computer-assisted telephone interviews in 2003-2004, with interview by adult proxy for children still 18 years of age at that time. We compared age-specific asthma prevalence with National Health Interview Survey estimates. RESULTS: Among 3,184 children enrolled, 28% were 5 years of age on 9/11; 34%, 5-11 years; and 39%, 12-17 years. Forty-five percent had a report of dust cloud exposure on 9/11. Half (53%) reported at least one new or worsened respiratory symptom, and 5.7% reported new asthma diagnoses. Before 9/11, age-specific asthma prevalence in enrolled children was similar to national estimates, but prevalence at interview was elevated among enrollees 5 years of age. Dust cloud exposure was associated with new asthma diagnosis (adjusted odds ratio = 2.3; 95% confidence interval, 1.5-3.5). CONCLUSIONS: Asthma prevalence after 9/11 among WTCHR enrollees 5 years of age was higher than national estimates, and new asthma diagnosis was associated with dust cloud exposure in all age groups. We will determine severity of asthma and persistence of other respiratory symptoms on follow-up surveys. JF - Environmental Health Perspectives AU - Thomas, Pauline A AU - Brackbill, Robert AU - Thalji, Lisa AU - DiGrande, Laura AU - Campolucci, Sharon AU - Thorpe, Lorna AU - Henning, Kelly PY - 2008 SP - 1383 EP - 1390 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Health KW - Asthma KW - Age KW - Exposure KW - Clouds KW - Estimates KW - Dust KW - Disasters KW - Streets KW - Diagnosis KW - Kindergartens KW - Adults KW - Adolescents KW - Proxy client servers KW - Confidence intervals KW - Elevated KW - Telephones KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743427811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Respiratory+and+Other+Health+Effects+Reported+in+Children+Exposed+to+the+World+Trade+Center+Disaster+of+11+September+2001&rft.au=Thomas%2C+Pauline+A%3BBrackbill%2C+Robert%3BThalji%2C+Lisa%3BDiGrande%2C+Laura%3BCampolucci%2C+Sharon%3BThorpe%2C+Lorna%3BHenning%2C+Kelly&rft.aulast=Thomas&rft.aufirst=Pauline&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1383&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Air Pollution and Odor in Communities Near Industrial Swine Operations AN - 743423962; 201004-31-0304795 (CE); 12103989 (EN) AB - BACKGROUND: Odors can affect health and quality of life. Industrialized animal agriculture creates odorant compounds that are components of a mixture of agents that could trigger symptoms reported by neighbors of livestock operations. OBJECTIVE: We quantified swine odor episodes reported by neighbors and the relationships of these episodes with environmental measurements. METHODS: Between September 2003 and September 2005, 101 nonsmoking volunteers living within 1.5 mi of industrial swine operations in 16 neighborhoods in eastern North Carolina completed twice-daily odor diaries for approximately 2 weeks. Meteorological conditions, hydrogen sulfide, and particulate matter or= 10 microm in aerodynamic diameter (PM10) were monitored in each neighborhood. We used mixed models to partition odor variance within and between people and between neighborhoods, and to quantify relationships between environmental factors and odor. RESULTS: Participants reported 1,655 episodes of swine odor. In nine neighborhoods, odor was reported on more than half of study-days. Odor ratings were related to temperature, PM10, and semivolatile PM10 in standard but not mixed models. In mixed models, odor increased 0.15 +/- 0.05 units (mean +/- SE) for a 1-ppb increase in H2S, and 0.45 +/- 0.14 units for a 10-microg/m3 increase in PM10 at wind speeds 6.75 miles per hour. The odds of reporting a change in daily activities due to odor increased 62% for each unit increase in average odor during the prior 12 hr (t-value = 7.17). CONCLUSIONS: This study indicates that malodor from swine operations is commonly present in these communities and that the odors reported by neighbors are related to objective environmental measurements and interruption of activities of daily life. JF - Environmental Health Perspectives AU - Wing, Steve AU - Horton, Rachel Avery AU - Marshall, Stephen W AU - Thu, Kendall AU - Tajik, Mansoureh AU - Schinasi, Leah AU - Schiffman, Susan S PY - 2008 SP - 1362 EP - 1368 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Odors KW - Swine KW - Health KW - Mathematical models KW - Communities KW - Air pollution KW - Ratings KW - Wings (aircraft) KW - Reporting KW - Livestock KW - Variance KW - Partitions KW - Diaries KW - Odorants KW - Standards KW - Agriculture KW - Copyrights KW - Hydrogen sulfide KW - Interruption KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743423962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Air+Pollution+and+Odor+in+Communities+Near+Industrial+Swine+Operations&rft.au=Wing%2C+Steve%3BHorton%2C+Rachel+Avery%3BMarshall%2C+Stephen+W%3BThu%2C+Kendall%3BTajik%2C+Mansoureh%3BSchinasi%2C+Leah%3BSchiffman%2C+Susan+S&rft.aulast=Wing&rft.aufirst=Steve&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1362&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Urinary Porphyrin Excretion in Children is Associated with Exposure to Organochlorine Compounds AN - 743421729; 201004-31-0304793 (CE); 12103987 (EN) AB - BACKGROUND: Hexachlorobenzene (HCB) and other organochlorines induce porphyria cutanea tarda (PCT) in animal studies. Evidence in humans, however, is contradictory. In neonates and adults from a population historically highly exposed to HCB (Flix, Catalonia, Spain), no relation with PCT or with porphyrin excretion was found. OBJECTIVES: We aimed to analyze the association between urinary porphyrin excretion and exposure to HCB and other organochlorinated compounds in children 4 years of age. METHODS: Our birth cohort included all newborns from Flix and the five surrounding towns (where no airborne pollution occurred). Among the 68 children with porphyrins we measured in cord blood, 52 children 4 years of age provided blood to measure organochlorine compounds, hair for methylmercury, and urine for porphyrin excretion pattern. RESULTS: Quantitative porphyrin excretion was within the normal values. However, total porphyrins, coproporphyrin I (CPI), and coproporphyrin III (CPIII) adjusted to creatinine excretion increased with increasing levels of HCB, 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p'-DDE), 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p'-DDT), and polychlorinated biphenyl congener 153 (PCB-153). We found no association with methylmercury. When we fitted multiple pollutant models, p,p'-DDE had the strongest association. We found these associations in children from both Flix and other towns, and they were independent of breast-feeding and of organochlorine and porphyrin levels at birth. CONCLUSION: HCB at current levels did not induce porphyria or increase uroporphyrins. However, the increase of urinary coproporphyrins suggests an incipient toxic effect of the organochlorines, especially for p,p'-DDE, on the hepatic heme-synthesis pathway that differs from the major effects seen in PCT. JF - Environmental Health Perspectives AU - Sunyer, Jordi AU - Alvarez-Pedrerol, Mar AU - To-Figueras, Jordi AU - Ribas-Fito, Nuria AU - Grimalt, Joan O AU - Herrero, Carmen PY - 2008 SP - 1407 EP - 1410 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Porphyrins KW - Excretion KW - Children KW - Towns KW - Health KW - Birth KW - Organochlorine compounds KW - Blood KW - Age KW - Adults KW - Toxic KW - Mathematical models KW - Congeners KW - Rope KW - Copyrights KW - Polychlorinated biphenyls KW - Hair KW - Creatinine KW - Pathways KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743421729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Urinary+Porphyrin+Excretion+in+Children+is+Associated+with+Exposure+to+Organochlorine+Compounds&rft.au=Sunyer%2C+Jordi%3BAlvarez-Pedrerol%2C+Mar%3BTo-Figueras%2C+Jordi%3BRibas-Fito%2C+Nuria%3BGrimalt%2C+Joan+O%3BHerrero%2C+Carmen&rft.aulast=Sunyer&rft.aufirst=Jordi&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1407&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Urinary Cadmium and Osteoporosis in U.S. Women [Greater-Than Or Equal To] 50 Years of Age: NHANES 1988-1994 and 1999-2004 AN - 743421699; 201004-31-0304725 (CE); 12103909 (EN) AB - BACKGROUND: Urinary cadmium (U-Cd) has been associated with decreased peripheral bone mineral density (BMD) and osteoporosis. This association, however, has not been confirmed using femoral BMD, the international standard for diagnosing osteoporosis, at levels 1.0 microg Cd/g creatinine. OBJECTIVES: Our goal was to investigate the statistical association between U-Cd, at levels or= 1 microg/g creatinine, and osteoporosis, as indicated by hip BMD and self-report in a population-based sample of U.S. women or= 50 years of age. METHODS: We drew data from the National Health and Nutrition Examination Surveys for 1988-1994 (n = 3,207) and 1999-2004 (n = 1,051). Osteoporosis was indicated by hip BMD cutoffs based on the international standard and self-report of physician diagnosis. We analyzed U-Cd levels for association with osteoporosis using multiple logistic regression. RESULTS: Women or= 50 years of age with U-Cd levels between 0.50 and 1.00 microg/g creatinine were at 43% greater risk for hip-BMD-defined osteoporosis, relative to those with levels or= 0.50 microg/g (odds ratio = 1.43; 95% confidence interval, 1.02-2.00; p = 0.04). We observed similar effect estimates using self-report of physician-diagnosed osteoporosis. Smokers did not show a statistically increased risk. CONCLUSIONS: Results suggest that U.S. women are at risk for osteoporosis at U-Cd levels below the U.S. Occupational Safety and Health Administration's 3-microg/g safety standard. Given null findings among smokers, dietary Cd, rather than tobacco, is the likely source of Cd-related osteoporosis risk for the U.S. female population or= 50 years of age. JF - Environmental Health Perspectives AU - Gallagher, Carolyn M AU - Kovach, John S AU - Meliker, Jaymie R PY - 2008 SP - 1338 EP - 1343 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Osteoporosis KW - Cadmium KW - Risk KW - Health KW - Age KW - Standards KW - Creatinine KW - Density KW - Bones KW - Statistical methods KW - Nutrition KW - Samples KW - Regression KW - Occupational safety KW - Surgical implants KW - Estimates KW - Diagnosis KW - Statistical analysis KW - Biomedical materials KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743421699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Urinary+Cadmium+and+Osteoporosis+in+U.S.+Women+%5BGreater-Than+Or+Equal+To%5D+50+Years+of+Age%3A+NHANES+1988-1994+and+1999-2004&rft.au=Gallagher%2C+Carolyn+M%3BKovach%2C+John+S%3BMeliker%2C+Jaymie+R&rft.aulast=Gallagher&rft.aufirst=Carolyn&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1338&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Margin-of-Exposure Approach to Assessment of Noncancer Risks of Dioxins Based on Human Exposure and Response Data AN - 743309416; 201004-31-0304799 (CE); 12103993 (EN) AB - BACKGROUND: Risk assessment of human environmental exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDFs) and other dioxin-like compounds is complicated by several factors, including limitations in measuring intakes because of the low concentrations of these compounds in foods and the environment and interspecies differences in pharmacokinetics and responses. OBJECTIVES: We examined the feasibility of relying directly on human studies of exposure and potential responses to PCDD/PCDFs and related compounds in terms of measured lipid-adjusted concentrations to assess margin of exposure (MOE) in a quantitative, benchmark dose (BMD)-based framework using representative exposure and selected response data sets. METHODS: We characterize estimated central tendency and upper-bound general U.S. population lipid-adjusted concentrations of PCDD/PCDFs from the 1970s and early 2000s based on available data sets. Estimates of benchmark concentrations for three example responses of interest (induction of cytochrome P4501A2 activity, dental anomalies, and neonatal thyroid hormone alterations) were derived based on selected human studies. RESULTS: The exposure data sets indicate that current serum lipid concentrations in young adults are approximately 6- to 7-fold lower than 1970s-era concentrations. Estimated MOEs for each end point based on current serum lipid concentrations range from 10 for neonatal thyroid hormone concentrations to 100 for dental anomalies-approximately 6-fold greater than would have existed during the 1970s. CONCLUSIONS: Human studies of dioxin exposure and outcomes can be used in a BMD framework for quantitative assessments of MOE. Incomplete exposure characterization can complicate the use of such studies in a BMD framework. JF - Environmental Health Perspectives AU - Aylward, Lesa L AU - Goodman, Julie E AU - Charnley, Gail AU - Rhomberg, Lorenz R PY - 2008 SP - 1344 EP - 1351 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Human KW - Data sets KW - Assessments KW - Lipids KW - Hormones KW - Health KW - Ecological risk assessment KW - Serums KW - Dioxins KW - Benchmarking KW - Risk KW - Adults KW - Estimates KW - Low concentrations KW - Cytochromes KW - Copyrights KW - Risk assessment KW - Foods KW - Feasibility KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743309416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Margin-of-Exposure+Approach+to+Assessment+of+Noncancer+Risks+of+Dioxins+Based+on+Human+Exposure+and+Response+Data&rft.au=Aylward%2C+Lesa+L%3BGoodman%2C+Julie+E%3BCharnley%2C+Gail%3BRhomberg%2C+Lorenz+R&rft.aulast=Aylward&rft.aufirst=Lesa&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1344&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Marked Liver Tumorigenesis by Helicobacter hepaticus Requires Perinatal Exposure AN - 743300831; 201004-31-0304798 (CE); 12103992 (EN) AB - BACKGROUND: Although severe hepatitis and liver tumors occur in a high percentage of A/J male mice naturally infected with Helicobacter hepaticus, these effects have not been observed after injection of adult mice with the bacteria. OBJECTIVES: We tested the hypothesis that perinatal exposure to the bacteria is required for liver tumorigenesis. METHODS: A/J female mice were infected by intragastric (ig) or intraperitoneal (ip) treatment with 1.5 x 10(8) H. hepaticus before pregnancy. We examined offspring at progressive time intervals, including some kept until natural death in old age. A/J, BALB/c, and C57BL/6 weanling male mice were similarly treated ig with the bacteria and observed for up to 2 years. RESULTS: After ip bacterial infection of A/J females, 41% of their male offspring developed hepatitis and 33% had hepatocellular tumors, including 18% with hepatocellular carcinoma. Treatment by the ig route resulted in a similar incidence of hepatitis in offspring (35%) but fewer total liver tumors (8%) and carcinomas (4%). By contrast, ig instillation of H. hepaticus in weanling A/J, C57BL/6, or BALB/c mice resulted in low incidence of hepatitis (0-20%) and few liver tumors, despite presence of bacteria confirmed in feces. CONCLUSIONS: Results indicate that a high incidence of liver tumors in mice infected with H. hepaticus requires perinatal exposure. Contributing perinatal factors could include known high sensitivity of neonatal liver to tumor initiation, and/or modulation of immune response to the bacterium or its toxins. Mechanisms of human perinatal sensitivity to such phenomena can be studied with this model. JF - Environmental Health Perspectives AU - Diwan, Bhalchandra A AU - Sipowicz, Marek AU - Logsdon, Daniel AU - Gorelick, Peter AU - Anver, Miriam R AU - Kasprzak, Kazimierz S AU - Anderson, Lucy M PY - 2008 SP - 1352 EP - 1356 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Bacteria KW - Liver KW - Mice KW - Tumors KW - Hepatitis KW - Incidence KW - Males KW - Health KW - Mathematical models KW - Females KW - Modulation KW - Adults KW - Pregnancy KW - Intervals KW - Toxins KW - Copyrights KW - Human KW - Age KW - Death KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743300831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Marked+Liver+Tumorigenesis+by+Helicobacter+hepaticus+Requires+Perinatal+Exposure&rft.au=Diwan%2C+Bhalchandra+A%3BSipowicz%2C+Marek%3BLogsdon%2C+Daniel%3BGorelick%2C+Peter%3BAnver%2C+Miriam+R%3BKasprzak%2C+Kazimierz+S%3BAnderson%2C+Lucy+M&rft.aulast=Diwan&rft.aufirst=Bhalchandra&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Impairment of NO-Dependent Relaxation in Intralobar Pulmonary Arteries: Comparison of Urban Particulate Matter and Manufactured Nanoparticles AN - 743296789; 201004-31-0304804 (CE); 12103998 (EN) AB - BACKGROUND AND OBJECTIVES: Because pulmonary circulation is the primary vascular target of inhaled particulate matter (PM), and nitric oxide is a major vasculoprotective agent, in this study we investigated the effect of various particles on the NO-cyclic guanosine monophosphate (cGMP) pathway in pulmonary arteries. METHODS: We used intrapulmonary arteries and/or endothelial cells, either exposed in vitro to particles or removed from PM-instilled animals for assessment of vasomotricity, cGMP and reactive oxygen species (ROS) levels, and cytokine/chemokine release. RESULTS: Endothelial NO-dependent relaxation and cGMP accumulation induced by acetylcholine (ACh) were both decreased after 24 hr exposure of rat intrapulmonary arteries to standard reference material 1648 (SRM1648; urban PM). Relaxation due to NO donors was also decreased by SRM1648, whereas responsiveness to cGMP analogue remained unaffected. Unlike SRM1648, ultrafine carbon black and ultrafine and fine titanium dioxide (TiO2) manufactured particles did not impair NO-mediated relaxation. SRM1648-induced decrease in relaxation response to ACh was prevented by dexamethasone (an anti-inflammatory agent) but not by antioxidants. Accordingly, SRM1648 increased the release of proinflammatory mediators (tumor necrosis factor-alpha, interleukin-8) from intrapulmonary arteries or pulmonary artery endothelial cells, but did not elevate ROS levels within intrapulmonary arteries. Decreased relaxation in response to ACh was also evidenced in intrapulmonary arteries removed from rats intratracheally instilled with SRM1648, but not with fine TiO2. CONCLUSION: In contrast to manufactured particles (including nanoparticles), urban PM impairs NO but not cGMP responsiveness in intrapulmonary arteries. We attribute this effect to oxidative-stress-independent inflammatory response, resulting in decreased guanylyl cyclase activation by NO. Such impairment of the NO pathway may contribute to urban-PM-induced cardiovascular dysfunction. JF - Environmental Health Perspectives AU - Courtois, Arnaud AU - Andujar, Pascal AU - Ladeiro, Yannick AU - Baudrimont, Isabelle AU - Delannoy, Estelle AU - Leblais, Veronique AU - Begueret, Hugues AU - Galland, Marie Annick Billon AU - Brochard, Patrick AU - Marano, Francelyne AU - Marthan, Roger AU - Muller, Bernard PY - 2008 SP - 1294 EP - 1299 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Arteries KW - Titanium dioxide KW - Impairment KW - Endothelial cells KW - Health KW - Ultrafines KW - Pathways KW - Nanoparticles KW - Activation KW - Assessments KW - Guanosines KW - Cytokines KW - Inflammatory response KW - Carbon black KW - In vitro testing KW - Dexamethasone KW - Tumors KW - Antioxidants KW - Analogue KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743296789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Impairment+of+NO-Dependent+Relaxation+in+Intralobar+Pulmonary+Arteries%3A+Comparison+of+Urban+Particulate+Matter+and+Manufactured+Nanoparticles&rft.au=Courtois%2C+Arnaud%3BAndujar%2C+Pascal%3BLadeiro%2C+Yannick%3BBaudrimont%2C+Isabelle%3BDelannoy%2C+Estelle%3BLeblais%2C+Veronique%3BBegueret%2C+Hugues%3BGalland%2C+Marie+Annick+Billon%3BBrochard%2C+Patrick%3BMarano%2C+Francelyne%3BMarthan%2C+Roger%3BMuller%2C+Bernard&rft.aulast=Courtois&rft.aufirst=Arnaud&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1294&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Lung Cancer and Vehicle Exhaust in Trucking Industry Workers AN - 743265476; 201004-31-0304801 (CE); 12103995 (EN) AB - BACKGROUND: An elevated risk of lung cancer in truck drivers has been attributed to diesel exhaust exposure. Interpretation of these studies specifically implicating diesel exhaust as a carcinogen has been limited because of limited exposure measurements and lack of work records relating job title to exposure-related job duties. OBJECTIVES: We established a large retrospective cohort of trucking company workers to assess the association of lung cancer mortality and measures of vehicle exhaust exposure. METHODS: Work records were obtained for 31,135 male workers employed in the unionized U.S. trucking industry in 1985. We assessed lung cancer mortality through 2000 using the National Death Index, and we used an industrial hygiene review and current exposure measurements to identify jobs associated with current and historical use of diesel-, gas-, and propane-powered vehicles. We indirectly adjusted for cigarette smoking based on an industry survey. RESULTS: Adjusting for age and a healthy-worker survivor effect, lung cancer hazard ratios were elevated in workers with jobs associated with regular exposure to vehicle exhaust. Mortality risk increased linearly with years of employment and was similar across job categories despite different current and historical patterns of exhaust-related particulate matter from diesel trucks, city and highway traffic, and loading dock operations. Smoking behavior did not explain variations in lung cancer risk. CONCLUSIONS: Trucking industry workers who have had regular exposure to vehicle exhaust from diesel and other types of vehicles on highways, city streets, and loading docks have an elevated risk of lung cancer with increasing years of work. JF - Environmental Health Perspectives AU - Garshick, Eric AU - Laden, Francine AU - Hart, Jaime E AU - Rosner, Bernard AU - Davis, Mary E AU - Eisen, Ellen A AU - Smith, Thomas J PY - 2008 SP - 1327 EP - 1332 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Trucks KW - Cancer KW - Lungs KW - Exhaust KW - Risk KW - Diesel KW - Diesel fuels KW - Freight transportation KW - Mortality KW - Elevated KW - Highways KW - Docks KW - Health KW - Smoking KW - Categories KW - Carcinogens KW - Streets KW - Drivers KW - Traffic flow KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743265476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Lung+Cancer+and+Vehicle+Exhaust+in+Trucking+Industry+Workers&rft.au=Garshick%2C+Eric%3BLaden%2C+Francine%3BHart%2C+Jaime+E%3BRosner%2C+Bernard%3BDavis%2C+Mary+E%3BEisen%2C+Ellen+A%3BSmith%2C+Thomas+J&rft.aulast=Garshick&rft.aufirst=Eric&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1327&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Longitudinal Study of Indoor Nitrogen Dioxide Levels and Respiratory Symptoms in Inner-City Children with Asthma AN - 743264761; 201004-31-0304785 (CE); 12103979 (EN) AB - BACKGROUND: The effect of indoor nitrogen dioxide concentrations on asthma morbidity among inner-city preschool children is uncertain. OBJECTIVES: Our goal was to estimate the effect of indoor NO2 concentrations on asthma morbidity in an inner-city population while adjusting for other indoor pollutants. METHODS: We recruited 150 children (2-6 years of age) with physician-diagnosed asthma from inner-city Baltimore, Maryland. Indoor air was monitored over a 72-hr period in the children's bedrooms at baseline and 3 and 6 months. At each visit, the child's caregiver completed a questionnaire assessing asthma symptoms over the previous 2 weeks and recent health care utilization. RESULTS: Children were 58% male, 91% African American, and 42% from households with annual income $25,000; 63% had persistent asthma symptoms. The mean (+/- SD) in-home NO2 concentration was 30.0 +/- 33.7 (range, 2.9-394.0) ppb. The presence of a gas stove and the use of a space heater or oven/stove for heat were independently associated with higher NO2 concentrations. Each 20-ppb increase in NO2 exposure was associated significantly with an increase in the number of days with limited speech [incidence rate ratio (IRR) = 1.15; 95% confidence interval (CI), 1.05-1.25], cough (IRR = 1.10; 95% CI, 1.02-1.18), and nocturnal symptoms (IRR = 1.09; 95% CI, 1.02-1.16), after adjustment for potential confounders. NO2 concentrations were not associated with increased health care utilization. CONCLUSIONS: Higher indoor NO2 concentrations were associated with increased asthma symptoms in preschool inner-city children. Interventions aimed at lowering NO2 concentrations in inner-city homes may reduce asthma morbidity in this vulnerable population. JF - Environmental Health Perspectives AU - Hansel, Nadia N AU - Breysse, Patrick N AU - McCormack, Meredith C AU - Matsui, Elizabeth C AU - Curtin-Brosnan, Jean AU - Williams, D'Ann L AU - Moore, Jennifer L AU - Cuhran, Jennifer L AU - Diette, Gregory B PY - 2008 SP - 1428 EP - 1432 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Nitrogen dioxide KW - Asthma KW - Indoor KW - Children KW - Stoves KW - Health KW - Health care KW - Utilization KW - Heaters KW - Bedrooms KW - Ovens KW - Households KW - Estimates KW - Preschool children KW - Cough KW - Confidence intervals KW - Speech KW - Incidence KW - Males KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743264761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Longitudinal+Study+of+Indoor+Nitrogen+Dioxide+Levels+and+Respiratory+Symptoms+in+Inner-City+Children+with+Asthma&rft.au=Hansel%2C+Nadia+N%3BBreysse%2C+Patrick+N%3BMcCormack%2C+Meredith+C%3BMatsui%2C+Elizabeth+C%3BCurtin-Brosnan%2C+Jean%3BWilliams%2C+D%27Ann+L%3BMoore%2C+Jennifer+L%3BCuhran%2C+Jennifer+L%3BDiette%2C+Gregory+B&rft.aulast=Hansel&rft.aufirst=Nadia&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1428&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Lead Exposures in U.S. Children, 2008: Implications for Prevention AN - 743257037; 201004-31-0304806 (CE); 12104000 (EN) AB - OBJECTIVE: We reviewed the sources of lead in the environments of U.S. children, contributions to children's blood lead levels, source elimination and control efforts, and existing federal authorities. Our context is the U.S. public health goal to eliminate pediatric elevated blood lead levels (EBLs) by 2010. DATA SOURCES: National, state, and local exposure assessments over the past half century have identified risk factors for EBLs among U.S. children, including age, race, income, age and location of housing, parental occupation, and season. DATA EXTRACTION AND SYNTHESIS: Recent national policies have greatly reduced lead exposure among U.S. children, but even very low exposure levels compromise children's later intellectual development and lifetime achievement. No threshold for these effects has been demonstrated. Although lead paint and dust may still account for up to 70% of EBLs in U.S. children, the U.S. Centers for Disease Control and Prevention estimates that or=30% of current EBLs do not have an immediate lead paint source, and numerous studies indicate that lead exposures result from multiple sources. EBLs and even deaths have been associated with inadequately controlled sources including ethnic remedies and goods, consumer products, and food-related items such as ceramics. Lead in public drinking water and in older urban centers remain exposure sources in many areas. CONCLUSIONS: Achieving the 2010 goal requires maintaining current efforts, especially programs addressing lead paint, while developing interventions that prevent exposure before children are poisoned. It also requires active collaboration across all levels of government to identify and control all potential sources of lead exposure, as well as primary prevention. JF - Environmental Health Perspectives AU - Levin, Ronnie AU - Brown, Mary Jean AU - Kashtock, Michael E AU - Jacobs, David E AU - Whelan, Elizabeth A AU - Rodman, Joanne AU - Schock, Michael R AU - Padilla, Alma AU - Sinks, Thomas PY - 2008 SP - 1285 EP - 1293 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Exposure KW - Painting KW - Health KW - Age KW - Blood KW - Active control KW - Remedies KW - Policies KW - Assessments KW - Drinking water KW - Position (location) KW - Risk KW - Disease control KW - Extraction KW - Occupation KW - Data sources KW - Estimates KW - Ethnic KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743257037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Lead+Exposures+in+U.S.+Children%2C+2008%3A+Implications+for+Prevention&rft.au=Levin%2C+Ronnie%3BBrown%2C+Mary+Jean%3BKashtock%2C+Michael+E%3BJacobs%2C+David+E%3BWhelan%2C+Elizabeth+A%3BRodman%2C+Joanne%3BSchock%2C+Michael+R%3BPadilla%2C+Alma%3BSinks%2C+Thomas&rft.aulast=Levin&rft.aufirst=Ronnie&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1285&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Hydroxylated Metabolites of the Polybrominated Diphenyl Ether Mixture DE-71 Are Weak Estrogen Receptor-[alpha] Ligands AN - 743244906; 201004-31-0304726 (CE); 12103910 (EN) AB - BACKGROUND: Polybrominated diphenyl ethers (PBDEs) are widely found in the environment and are suspected endocrine disruptors. We previously identified six hydroxylated metabolites of PBDE (OH-PBDEs) in treated mice. OBJECTIVE: We tested the hypothesis that OH-PBDEs would interact with and alter activity of estrogen receptor-alpha (ER-alpha). METHODS: We tested estrogenicity using two assays: 3H-estradiol (3H-E2) displacement from recombinant ER-alpha and induction of reporter gene (ERE-luciferase) in cultured cells. We incubated the PBDE mixture DE-71 with rat liver microsomes and tested the resultant metabolite mixture for estrogenic activity. We also determined relative estrogenic potential of individual hydroxylated PBDE congeners. RESULTS: Reporter gene activity was increased by DE-71 that had been subjected to microsomal metabolism. DE-71 did not displace E2 from ER-alpha, but all six of the OH-PBDE metabolites did. para-Hydroxylated metabolites displayed a 10- to 30-fold higher affinity for ER-alpha compared with ortho-hydroxylated PBDEs, and one produced a maximal effect 30% higher than that produced by E2. Coadministration of E2 and DE-71, or certain of its metabolites, yielded reporter activity greater than either chemical alone. Two ortho-OH-PBDEs were antiestrogenic in the reporter assay. CONCLUSIONS: The observations--that the DE-71 mixture did not displace 3H-E2 from ER-alpha while the hydroxylated metabolites did-suggest that the weak estrogenic effects of DE-71 are due to metabolic activation of individual congeners. However, the behavior of DE-71 and its metabolites, when co-administered with E2, suggest a secondary, undetermined mechanism from classical ER-alpha activation. JF - Environmental Health Perspectives AU - Mercado-Feliciano, Minerva AU - Bigsby, Robert M PY - 2008 SP - 1315 EP - 1321 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Metabolites KW - Displacement KW - Activation KW - Ethers KW - Estrogens KW - Health KW - Congeners KW - Genes KW - Assaying KW - Recombinant KW - Mice KW - Endocrine disruptors KW - Affinity KW - Copyrights KW - Resultants KW - Metabolism KW - Liver KW - Ligands KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743244906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Hydroxylated+Metabolites+of+the+Polybrominated+Diphenyl+Ether+Mixture+DE-71+Are+Weak+Estrogen+Receptor-%5Balpha%5D+Ligands&rft.au=Mercado-Feliciano%2C+Minerva%3BBigsby%2C+Robert+M&rft.aulast=Mercado-Feliciano&rft.aufirst=Minerva&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1315&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Developmental Lead Exposure Induces Tactile Defensiveness in Rhesus Monkeys (Macaca Mulatta) AN - 743184049; 201004-31-0304802 (CE); 12103996 (EN) AB - BACKGROUND: Tactile defensiveness in children is associated with difficult social relations, emotional dysregulation, and inattention. However, there are no studies of lead exposure and tactile defensiveness in children or animals in spite of the fact that lead exposure is also associated with inattention and emotional dysregulation. OBJECTIVES: In this study we tested whether lead exposure induces tactile defensiveness in rhesus monkeys. METHODS: We tested 61 monkeys from a 3 (no lead, 1-year lead, 2-year lead) x 2 (succimer chelation or not) factorial experiment for tactile defensiveness at 4 years of age. Lead-treated monkeys had been orally administered lead in a daily milk solution from 8 days of life to either 1 or 2 years of age to produce blood lead levels of 35-40 mg/dL. Succimer chelation therapy or placebo was administered at 1 year of age. We measured tactile defensiveness using six repeated trials of each of three textures as a swipe to the cheek and neck. RESULTS: Lead-exposed monkeys showed higher negative responses to repeated tactile stimulation compared with controls. Blood lead during the first 3 months of life was positively correlated with the negative response on the tactile defensiveness test. There was an interaction of lead exposure x succimer chelation x trials, but it is not clear that succimer chelation was beneficial with respect to tactile defensiveness. CONCLUSIONS: This is the first report to implicate lead as a potential cause of tactile defensiveness. Research should examine whether lead exposure is associated with tactile defensiveness in children. JF - Environmental Health Perspectives AU - Moore, Colleen F AU - Gajewski, Lisa L AU - Laughlin, Nellie K AU - Luck, Melissa L AU - Larson, Julie A AU - Schneider, Mary L PY - 2008 SP - 1322 EP - 1326 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Tactile KW - Monkeys KW - Chelation KW - Texture KW - Children KW - Age KW - Health KW - Blood KW - Surface layer KW - Milk KW - Factorial experiments KW - Correlation KW - Therapy KW - Stimulation KW - Control equipment KW - Copyrights KW - Animals KW - Necks KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743184049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Developmental+Lead+Exposure+Induces+Tactile+Defensiveness+in+Rhesus+Monkeys+%28Macaca+Mulatta%29&rft.au=Moore%2C+Colleen+F%3BGajewski%2C+Lisa+L%3BLaughlin%2C+Nellie+K%3BLuck%2C+Melissa+L%3BLarson%2C+Julie+A%3BSchneider%2C+Mary+L&rft.aulast=Moore&rft.aufirst=Colleen&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1322&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Case-Control Study of Blood Lead Levels and Attention Deficit Hyperactivity Disorder in Chinese Children AN - 743153482; 201004-31-0304792 (CE); 12103986 (EN) AB - BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) and lead exposure are high-prevalence conditions among children. OBJECTIVE: Our goal was to investigate the association between ADHD and blood lead levels (BLLs) in Chinese children, adjusting for known ADHD risk factors and potential confounding variables. METHODS: We conducted a pair-matching case-control study with 630 ADHD cases and 630 non-ADHD controls 4-12 years of age, matched on the same age, sex, and socioeconomic status. The case and control children were systematically evaluated via structured diagnostic interviews, including caregiver interviews, based on the Diagnostic and Statistical Manual of Mental Disorders, 4th ed., revised criteria (DSM-IV-R). We evaluated the association between BLLs and ADHD using the Pearson chi-square test for categorical variables and the Student t-test for continuous data. We then performed conditional multiple variables logistic regression analyses with backward stepwise selection to predict risk factors for ADHD. RESULTS: There was a significant difference in BLLs between ADHD cases and controls. ADHD cases were more likely to have been exposed to lead during childhood than the non-ADHD control subjects, with adjustment for other known risk factors [children with BLLs or= 10 microg/dL vs. or= 5 microg/dL; OR = 6.0; 95% confidence interval (CI) = 4.10-8.77, p 0.01; 5-10 microg/dL vs.or= 5 microg/dL, OR = 4.9; 95% CI = 3.47-6.98, p 0.01]. These results were not modified by age and sex variables. CONCLUSIONS: This was the largest sample size case-control study to date to study the association between BLLs and ADHD in Chinese children. ADHD may be an additional deleterious outcome of lead exposure during childhood, even when BLLs are 10 microg/dL. JF - Environmental Health Perspectives AU - Wang, Hui-Li AU - Chen, Xiang-Tao AU - Yang, Bin AU - Ma, Fang-Li AU - Wang, Shu AU - Tang, Ming-Liang AU - Hao, Ming-Gao AU - Ruan, Di-Yun PY - 2008 SP - 1401 EP - 1406 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Control equipment KW - Risk KW - Age KW - Diagnostic systems KW - Disorders KW - Health KW - Sex KW - Blood KW - Statistical methods KW - Samples KW - Statistical analysis KW - Criteria KW - Regression analysis KW - Confidence intervals KW - Copyrights KW - Logistics KW - Mental disorders KW - Exposure KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743153482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Case-Control+Study+of+Blood+Lead+Levels+and+Attention+Deficit+Hyperactivity+Disorder+in+Chinese+Children&rft.au=Wang%2C+Hui-Li%3BChen%2C+Xiang-Tao%3BYang%2C+Bin%3BMa%2C+Fang-Li%3BWang%2C+Shu%3BTang%2C+Ming-Liang%3BHao%2C+Ming-Gao%3BRuan%2C+Di-Yun&rft.aulast=Wang&rft.aufirst=Hui-Li&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Community-Based Participatory Research: A Vehicle to Promote Public Engagement for Environmental Health in China AN - 743129595; 201004-31-0304807 (CE); 12104001 (EN) AB - BACKGROUND: In the past 25 years, China has experienced remarkable economic growth and rapid agricultural-to-industrial and rural-to-urban transitions. As a consequence, China now faces many daunting environmental challenges that are significantly affecting human health and quality of life, including indoor and outdoor air pollution, water pollution, deforestation, loss of agricultural land, and sustainability. Chinese government leaders have recently emphasized the need for better environmental protection practices along with interventions involving strong public participation. OBJECTIVES: Community-based participatory research (CBPR) is a collaborative approach to research that involves community members, organizational representatives, and researchers as equal participants in all phases of the research process. Over the past 15 years, CBPR has gained recognition and acceptance and is now valued as a means to effect change and provide scientific knowledge relevant to human health and the environment. In this article we highlight the success of CBPR in the United States and suggest that it could be a useful model for addressing environmental health problems in the People's Republic of China. DISCUSSION: CBPR can reduce the tension between science and society by promoting genuine communication, by enabling scientists and administrators to listen and respond to the public, by allowing communities to help shape the research agenda, and by increasing accountability of researchers and governments to the public. CONCLUSIONS: CBPR can potentially help improve environmental health in China, but it is likely to take a different form than it has in the West because the government will be leading the way. JF - Environmental Health Perspectives AU - Ali, Robbie AU - Olden, Kenneth AU - Xu, Shunqing PY - 2008 SP - 1281 EP - 1284 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Governments KW - Communities KW - Agronomy KW - Human KW - Economics KW - Air pollution KW - Sustainability KW - Rapids KW - Water pollution KW - Land KW - Indoor KW - Recognition KW - Farmlands KW - Copyrights KW - Deforestation KW - Acceptance KW - Phases KW - Scientists KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743129595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Community-Based+Participatory+Research%3A+A+Vehicle+to+Promote+Public+Engagement+for+Environmental+Health+in+China&rft.au=Ali%2C+Robbie%3BOlden%2C+Kenneth%3BXu%2C+Shunqing&rft.aulast=Ali&rft.aufirst=Robbie&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1281&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Birth Delivery Mode Modifies the Associations between Prenatal Polychlorinated Biphenyl (PCB) and Polybrominated Diphenyl Ether (PBDE) and Neonatal Thyroid Hormone Levels AN - 743102850; 201004-31-0304789 (CE); 12103983 (EN) AB - BACKGROUND: Developing infants may be especially sensitive to hormone disruption from chemicals including polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). OBJECTIVE: We investigated relationships between cord serum levels of PCBs and PBDEs and thyroid hormones measured in cord blood serum and neonatal blood spots. METHODS: We measured PCBs and PBDEs, thyrotropin (TSH), thyroxine (T4) and free T4 (FT4) in cord blood serum from 297 infants who were delivered at the Johns Hopkins Hospital in 2004-2005. We abstracted results of total T4 (TT4) measured in blood spots collected in the hospital and at neonatal visits. We used delivery mode (augmented vaginal deliveries and nonelective cesarean deliveries) as a surrogate for intrapartum stress, which is known to alter cord blood thyroid hormones. RESULTS: In the full study population, no compounds were associated with a change in average TSH, FT4, or TT4. BDE-100 was associated with increased odds of low cord TT4, BDE-153 with increased odds of low cord TT4 and FT4, and no compounds were associated with increased odds of high TSH. For infants born by spontaneous, vaginal, unassisted deliveries, PCBs were associated with lower cord TT4 and FT4 and lower TT4 measured in neonatal blood spots. PBDEs showed consistent but mainly nonsignificant negative associations with TT4 and FT4 measurements. CONCLUSIONS: Prenatal PCB and PBDE exposures were associated with reduced TT4 and FT4 levels among infants born by spontaneous, unassisted vaginal delivery. Intrapartum stress associated with delivery mode may mask hormonal effects of PCBs and PBDEs. JF - Environmental Health Perspectives AU - Herbstman, Julie B AU - Sjoedin, Andreas AU - Apelberg, Benjamin J AU - Witter, Frank R AU - Halden, Rolf U AU - Patterson, Donald G AU - Panny, Susan R AU - Needham, Larry L AU - Goldman, Lynn R PY - 2008 SP - 1376 EP - 1382 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Rope KW - Blood KW - Infants KW - Hormones KW - Spots KW - Serums KW - Ethers KW - Circuit boards KW - Spontaneous KW - Health KW - Hospitals KW - Polychlorinated biphenyls KW - Printed circuits KW - Stresses KW - Thyroxine KW - Masks KW - Copyrights KW - Disruption KW - Birth KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743102850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Birth+Delivery+Mode+Modifies+the+Associations+between+Prenatal+Polychlorinated+Biphenyl+%28PCB%29+and+Polybrominated+Diphenyl+Ether+%28PBDE%29+and+Neonatal+Thyroid+Hormone+Levels&rft.au=Herbstman%2C+Julie+B%3BSjoedin%2C+Andreas%3BApelberg%2C+Benjamin+J%3BWitter%2C+Frank+R%3BHalden%2C+Rolf+U%3BPatterson%2C+Donald+G%3BPanny%2C+Susan+R%3BNeedham%2C+Larry+L%3BGoldman%2C+Lynn+R&rft.aulast=Herbstman&rft.aufirst=Julie&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1376&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Built Environment and Physical Functioning in Hispanic Elders: The Role of "Eyes on the Street" AN - 743095058; 201004-31-0304805 (CE); 12103999 (EN) AB - BACKGROUND: Research on neighborhood effects increasingly includes the influences of the built environment on health and social well-being. OBJECTIVES: In this population-based study in a low-socioeconomic-status (SES), Hispanic neighborhood, we examined whether architectural features of the built environment theorized to promote direct observations and interactions (e.g., porches, stoops) predicted Hispanic elders' social support and psychological and physical functioning. METHODS: We coded built-environment features for all 3,857 lots in the 403-block area of an urban Miami, Florida, community. We then conducted three annual assessments of social support, psychological distress, and physical functioning in a population-based sample of 273 low-SES Hispanic elders (70-100 years of age). We used structural equation modeling analytic techniques to examine hypothesized relationships between the built environment and elders' social support, psychological distress, and physical functioning over a 3-year period. RESULTS: After controlling for age, sex, and income, architectural features of the built environment theorized to facilitate visual and social contact had a significant direct relationship with elders' physical functioning as measured 3 years later, and an indirect relationship through social support and psychological distress. Further binomial regression analyses suggested that elders living on blocks marked by low levels of positive front entrance features were 2.7 times as likely to have subsequent poor levels of physical functioning, compared with elders living on blocks with a greater number of positive front entrance features [b = 0.99; chi(2) (1 df) = 3.71; p = 0.05; 95% confidence interval, 1.0-7.3]. CONCLUSIONS: Architectural features that facilitate visual and social contacts may be a protective factor for elders' physical functioning. JF - Environmental Health Perspectives AU - Brown, Scott C AU - Mason, Craig A AU - Perrino, Tatiana AU - Lombard, Joanna L AU - Martinez, Frank AU - Plater-Zyberk, Elizabeth AU - Spokane, Arnold R AU - Szapocznik, Jose PY - 2008 SP - 1300 EP - 1307 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Architecture KW - Health KW - Contact KW - Mathematical analysis KW - Entrances KW - Visual KW - Age KW - Assessments KW - Protective KW - Regression analysis KW - Low level KW - Confidence intervals KW - Communities KW - Binomials KW - Copyrights KW - Income KW - Sex KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743095058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Built+Environment+and+Physical+Functioning+in+Hispanic+Elders%3A+The+Role+of+%22Eyes+on+the+Street%22&rft.au=Brown%2C+Scott+C%3BMason%2C+Craig+A%3BPerrino%2C+Tatiana%3BLombard%2C+Joanna+L%3BMartinez%2C+Frank%3BPlater-Zyberk%2C+Elizabeth%3BSpokane%2C+Arnold+R%3BSzapocznik%2C+Jose&rft.aulast=Brown&rft.aufirst=Scott&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1300&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Prenatal Exposure to Perfluorooctanoate (PFOA) and Perfluorooctanesulfonate (PFOS) and Maternally Reported Developmental Milestones in Infancy AN - 743072888; 201004-31-0304791 (CE); 12103985 (EN) AB - BACKGROUND: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are fluorinated organic compounds present in the general population at low concentrations. Animal studies have shown that they may affect neuromuscular development at high concentrations. OBJECTIVES: We investigated the association between plasma levels of PFOS and PFOA in pregnant women and motor and mental developmental milestones of their children. METHODS: We randomly selected 1,400 pairs of pregnant women and their children from the Danish National Birth Cohort. PFOS and PFOA were measured in maternal blood samples taken in early pregnancy. Apgar score was abstracted from the National Hospital Discharge Register in Denmark. Developmental milestones were reported by mothers using highly structured questionnaires when the children were around 6 months and 18 months of age. RESULTS: Mothers who had higher levels of PFOA and PFOS gave birth to children who had similar Apgar scores and reached virtually all of the development milestones at the same time as children born to mothers with lower exposure levels. Children who were born to mothers with higher PFOS levels were slightly more likely to start sitting without support at a later age. CONCLUSION: We found no convincing associations between developmental milestones in early childhood and levels of PFOA or PFOS as measured in maternal plasma early in pregnancy. JF - Environmental Health Perspectives AU - Fei, Chunyuan AU - McLaughlin, Joseph K AU - Lipworth, Loren AU - Olsen, Joern PY - 2008 SP - 1391 EP - 1395 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Health KW - Birth KW - Age KW - Pregnancy KW - Hospitals KW - Copyrights KW - Blood KW - Motors KW - Registers KW - Discharge KW - Organic compounds KW - Fluorination KW - Animals KW - Low concentrations KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743072888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prenatal+Exposure+to+Perfluorooctanoate+%28PFOA%29+and+Perfluorooctanesulfonate+%28PFOS%29+and+Maternally+Reported+Developmental+Milestones+in+Infancy&rft.au=Fei%2C+Chunyuan%3BMcLaughlin%2C+Joseph+K%3BLipworth%2C+Loren%3BOlsen%2C+Joern&rft.aulast=Fei&rft.aufirst=Chunyuan&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1391&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Review of usnic acid and Usnea barbata toxicity. AN - 69831200; 19034791 AB - Usnic acid is a prominent secondary lichen metabolite that has been used for various purposes worldwide. Crude extracts of usnic acid or pure usnic acid have been marketed in the United States as dietary supplements to aid in weight loss. The US Food and Drug Administration (FDA) received 21 reports of liver toxicity related to the ingestion of dietary supplements that contain usnic acid. This prompted the FDA to issue a warning about one such supplement, LipoKinetix, in 2001 (http://www.cfsan.fda.gov/~dms/ds-lipo.html). Subsequently, usnic acid and Usnea barbata lichen were nominated by the National Toxicology Program (NTP) for toxicity evaluations. At present, a toxicological evaluation of usnic acid is being conducted by the NTP. This review focuses on the recent findings of usnic acid-induced toxicities and their underlying mechanisms of action. JF - Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews AU - Guo, Lei AU - Shi, Qiang AU - Fang, Jia-Long AU - Mei, Nan AU - Ali, A Afshan AU - Lewis, Sherry M AU - Leakey, Julian E A AU - Frankos, Vasilios H AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. lei.guo@fda.hhs.gov PY - 2008 SP - 317 EP - 338 VL - 26 IS - 4 KW - Benzofurans KW - 0 KW - Plant Extracts KW - usnic acid KW - 0W584PFJ77 KW - Index Medicus KW - Animals KW - Mutagenicity Tests KW - Liver -- drug effects KW - Humans KW - Weight Loss KW - Plant Extracts -- pharmacology KW - Benzofurans -- pharmacokinetics KW - Plant Extracts -- toxicity KW - Plant Extracts -- pharmacokinetics KW - Usnea -- chemistry KW - Benzofurans -- toxicity KW - Benzofurans -- pharmacology KW - Benzofurans -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69831200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.atitle=Review+of+usnic+acid+and+Usnea+barbata+toxicity.&rft.au=Guo%2C+Lei%3BShi%2C+Qiang%3BFang%2C+Jia-Long%3BMei%2C+Nan%3BAli%2C+A+Afshan%3BLewis%2C+Sherry+M%3BLeakey%2C+Julian+E+A%3BFrankos%2C+Vasilios+H&rft.aulast=Guo&rft.aufirst=Lei&rft.date=2008-10-01&rft.volume=26&rft.issue=4&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.issn=1532-4095&rft_id=info:doi/10.1080%2F10590500802533392 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-29 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10590500802533392 ER - TY - JOUR T1 - Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrier. AN - 69764921; 18991857 AB - Understanding the neurotoxic effects of acute high-dose exposures of laboratory animals to methamphetamine (METH) and amphetamine (AMPH) is of relevance to understanding the neurotoxicity incurred in humans from overdose or abuse of these substances. We present recent findings on the neurodegenerative effects of both a single high dose of 40 mg/kg and a 4-dose exposure to AMPH in the rat. Comparing these results with those we have previously observed in rodents exposed to either AMPH or METH helps further address how dose, hyperthermia, seizures and blood-brain barrier (BBB) disruption interact to produce neurodegeneration. With regard to the 4-dose paradigm of AMPH exposure in the rat, our recent data, combined with previous findings, clearly show the importance of dose and hyperthermic interactions in producing neurodegeneration. The single high AMPH dose invariably resulted in extreme hyperthermia and brief episodes of clonic-tonic seizure activity in many rats. However, motor behavior indicative of status epilepticus was not observed in rats receiving the 40 mg/kg AMPH, which contrasts with what we have previously seen with 40 mg/kg METH dose in the mouse. This may explain why, unlike the mice given METH, there was minimal BBB disruption in the amygdala of rats. Nonetheless, in some of the surviving rats there was extensive neurodegeneration in the hippocampus and intralaminar and ventromedial/lateral thalamic nuclei. Early BBB disruption was seen in the hippocampus and may play an important role in the subsequent neurodegeneration. The fact that status epilepticus does not occur in rats that have major hippocampal and thalamic degeneration indicates that such damage may also occur in humans exposed to high doses of AMPH or METH in the absence of status epilepticus or prominent motor manifestations of seizure activity. JF - Annals of the New York Academy of Sciences AU - Bowyer, John F AU - Thomas, Monzy AU - Schmued, Larry C AU - Ali, Syed F AD - Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA. john.bowyer@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 127 EP - 139 VL - 1139 KW - Central Nervous System Stimulants KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Humans KW - Mice KW - Male KW - Hippocampus -- drug effects KW - Hippocampus -- anatomy & histology KW - Seizures -- chemically induced KW - Fever -- chemically induced KW - Blood-Brain Barrier -- drug effects KW - Central Nervous System Stimulants -- pharmacology KW - Nerve Degeneration -- pathology KW - Nerve Degeneration -- chemically induced KW - Blood-Brain Barrier -- pathology KW - Amphetamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69764921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Brain+region-specific+neurodegenerative+profiles+showing+the+relative+importance+of+amphetamine+dose%2C+hyperthermia%2C+seizures%2C+and+the+blood-brain+barrier.&rft.au=Bowyer%2C+John+F%3BThomas%2C+Monzy%3BSchmued%2C+Larry+C%3BAli%2C+Syed+F&rft.aulast=Bowyer&rft.aufirst=John&rft.date=2008-10-01&rft.volume=1139&rft.issue=&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1432.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-09 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1432.005 ER - TY - JOUR T1 - Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury. AN - 69763314; 18991870 AB - The psychostimulant 3,4-,ethylenedioxymethamphetamine (MDMA, "ecstasy") is known to induce hyperthermia and alterations in neurochemical metabolism in the CNS. However, the detailed cellular or molecular mechanisms behind MDMA-induced neurotoxicity are still not well known. Since MDMA induces profound hyperthermia that could lead to intense cellular stress and cause disruption of the blood-brain barrier (BBB), this investigation examined the effects of acute MDMA on BBB dysfunction, brain edema, and cell injury in rats and mice. When MDMA (40 mg/kg, i.p.) was administered to rats or mice, these animals exhibited profound behavioral disturbances (hyperactivity and hyperlocomotion) and hyperthermia (>40 to 41 degrees C) at 4 h. At this time, the leakage of Evans blue dye was evident, particularly in the cerebellum, hippocampus, cortex, thalamus, and hypothalamus. This effect was most pronounced in mice compared to rats. Marked increase in brain water along with Na(+), K(+), and Cl(-) content was also seen in the aforementioned brain regions. Presence of distorted neuronal and glial cells in brain regions associated with leakage of Evans blue is quite common in MDMA-treated animals. Increased albumin immunoreactivity, indicating breakdown of the BBB, and upregulation of glial fibrillary acidic protein (GFAP), suggesting activation of astrocytes, were seen in most brain regions showing edematous changes. Upregulation of heat-shock protein (HSP72) immunoreactivity in the nuclei and cell cytoplasm of the neurons located in the edematous brain regions are quite common. Taken together, these observations are the first to show that MDMA has the capacity to disrupt BBB permeability to proteins and to induce the formation of edema, probably by inducing hyperthermia and cellular stress, as evident with HSP overexpression leading to cell injury. JF - Annals of the New York Academy of Sciences AU - Sharma, Hari Shanker AU - Ali, Syed F AD - Laboratory of Neurochemistry, Division of Neurotoxicology, National Center of Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. Sharma@surgsci.uu.se Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 242 EP - 258 VL - 1139 KW - Albumins KW - 0 KW - Coloring Agents KW - Hallucinogens KW - Heat-Shock Proteins KW - Evans Blue KW - 45PG892GO1 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Albumins -- metabolism KW - Heat-Shock Proteins -- metabolism KW - Animals KW - Astrocytes -- cytology KW - Evans Blue -- metabolism KW - Body Temperature -- drug effects KW - Coloring Agents -- metabolism KW - Mice KW - Rats KW - Behavior, Animal -- drug effects KW - Rats, Wistar KW - Mice, Inbred C57BL KW - Male KW - Astrocytes -- metabolism KW - Fever -- chemically induced KW - Blood-Brain Barrier -- drug effects KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Brain Edema -- chemically induced KW - Neurons -- cytology KW - Hallucinogens -- pharmacology KW - Blood-Brain Barrier -- pathology KW - N-Methyl-3,4-methylenedioxyamphetamine -- pharmacology KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69763314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Acute+administration+of+3%2C4-methylenedioxymethamphetamine+induces+profound+hyperthermia%2C+blood-brain+barrier+disruption%2C+brain+edema+formation%2C+and+cell+injury.&rft.au=Sharma%2C+Hari+Shanker%3BAli%2C+Syed+F&rft.aulast=Sharma&rft.aufirst=Hari&rft.date=2008-10-01&rft.volume=1139&rft.issue=&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1432.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-09 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1432.052 ER - TY - JOUR T1 - Transcriptional correlates of human substance use. AN - 69762402; 18991846 AB - Drugs of abuse produce both acute and chronic changes in brain function, each of which is reflected in altered gene expression patterns. A number of large-scale gene expression studies have employed microarray analysis of human postmortem brain to identify transcriptional correlates of antemortem substance use. These studies have identified changes in transcripts encoding proteins functionally involved in neuronal function and synaptic plasticity, oligodendrocyte function and myelination, lipid and energy metabolism, mitochondrial function, oxidative phosphorylation, and cytoskeleton-related signal transduction. Overall, different types of substance use appear to share some of these effects, but there are more differences than similarities in gene expression for different types of substance use. Moreover, data suggest that transcriptional subtypes within a diagnostic classification of substance use may occur. These transcriptional subtypes, or "endophenotypes," may reflect complex patterns of substance use and co-morbid neuropsychiatric disorders or other diseases, which may interact with substance use to differentially affect gene expression. A broader understanding of the manner in which substance abuse causes long-term changes in brain function may be obtained from studies replicating and expanding the present gene expression data. In particular, cross-referencing comprehensive transcriptional data on regional and/or substance use-specific changes with genetic and proteomic data may further aid in identifying candidate biomarkers of altered brain function in substance-use disorders. JF - Annals of the New York Academy of Sciences AU - Lehrmann, Elin AU - Freed, William J AD - Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 34 EP - 42 VL - 1139 KW - Index Medicus KW - Gene Expression Profiling KW - Autopsy KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Brain -- anatomy & histology KW - Cluster Analysis KW - Brain -- physiology KW - Substance-Related Disorders -- physiopathology KW - Substance-Related Disorders -- diagnosis KW - Transcription, Genetic KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69762402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Transcriptional+correlates+of+human+substance+use.&rft.au=Lehrmann%2C+Elin%3BFreed%2C+William+J&rft.aulast=Lehrmann&rft.aufirst=Elin&rft.date=2008-10-01&rft.volume=1139&rft.issue=&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1432.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-09 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurobiol Dis. 2005 Apr;18(3):649-55 [15755690] Biol Psychiatry. 2005 Jan 1;57(1):96-101 [15607306] Am J Psychiatry. 2005 Aug;162(8):1403-13 [16055761] Brain Res Mol Brain Res. 2005 Oct 3;139(2):317-32 [16122832] Neuroimage. 2005 Dec;28(4):904-14 [16061398] Neuropsychopharmacology. 2006 Mar;31(3):644-50 [16123763] J Nerv Ment Dis. 2006 Mar;194(3):164-72 [16534433] Neuropsychopharmacology. 2006 Apr;31(4):768-77 [16160706] J Clin Psychiatry. 2006 Feb;67(2):247-57 [16566620] Neuropsychopharmacology. 2006 Jul;31(7):1574-82 [16292326] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4680-5 [11930015] J Neurochem. 2002 May;81(4):802-13 [12065639] Pharmacogenomics J. 2003;3(1):27-40 [12629581] J Neurochem. 2003 May;85(3):543-62 [12694381] Drug Alcohol Depend. 2003 May 21;70(2):117-25 [12732403] J Neurosci Res. 2003 Jun 15;72(6):756-67 [12774316] Eur J Neurosci. 2003 May;17(10):2212-8 [12786988] Curr Mol Med. 2003 Aug;3(5):437-46 [12942997] BMC Bioinformatics. 2003 Sep 8;4:37 [12962547] Brain Res Bull. 2006 Jul 31;70(3):251-9 [16861111] Neuropsychopharmacology. 2006 Oct;31(10):2304-12 [16710320] Biol Psychiatry. 2006 Sep 15;60(6):650-8 [16997002] Brain Res. 2006 Dec 6;1123(1):1-11 [17045977] PLoS One. 2006;1:e114 [17205118] Int J Neuropsychopharmacol. 2007 Aug;10(4):557-63 [17291371] Int J Neuropsychopharmacol. 2007 Aug;10(4):547-55 [17291372] Alcohol Clin Exp Res. 2007 Sep;31(9):1460-6 [17625000] Addict Biol. 2008 Mar;13(1):105-17 [18201295] Mol Psychiatry. 2006 Jul;11(7):615, 663-79 [16636682] Alcohol Clin Exp Res. 2000 Dec;24(12):1873-82 [11141048] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4746-51 [11296301] Neuropsychopharmacology. 2004 Feb;29(2):373-84 [14583743] Biol Psychiatry. 2004 Feb 15;55(4):346-52 [14960286] J Neurochem. 2004 Mar;88(5):1211-9 [15009677] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] J Neurochem. 2004 Sep;90(5):1050-8 [15312160] J Neurosci Res. 2004 Sep 15;77(6):858-66 [15334603] Biol Psychiatry. 1993 Mar 15;33(6):456-66 [8098224] J Neurochem. 1993 Jul;61(1):1-11 [7685811] Am J Psychiatry. 1996 Apr;153(4):533-7 [8599402] Neuron. 1997 Sep;19(3):591-611 [9331351] J Neurochem. 2005 Apr;93(2):359-70 [15816859] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1432.027 ER - TY - JOUR T1 - Histopathology of vascular injury in Sprague-Dawley rats treated with phosphodiesterase IV inhibitor SCH 351591 or SCH 534385. AN - 69717086; 18776163 AB - Histopathological and immunohistochemical studies were conducted to characterize vascular injuries in rats treated with phosphodiesterase (PDE) IV inhibitors SCH 351591 or SCH 534385. Sprague-Dawley rats were administered PDE IV inhibitors by gavage at a range of doses and times. The two PDE IV inhibitors induced comparable levels of vascular injury, primarily in the mesentery and to a lesser extent in the pancreas, kidney, liver, small intestine, and stomach. Mesenteric vascular changes occurred as early as one hour, progressively developed over twenty-four to forty-eight hours, peaked at seventy-two hours, and gradually subsided from seven to nine days. The typical morphology of the vascular toxicity consisted of hemorrhage and necrosis of arterioles and arteries, microvascular injury, fibrin deposition, and perivascular inflammation of a variety of blood vessels. The incidence and severity of mesenteric vascular injury increased in a time- and dose-dependent manner in SCH 351591- or SCH 534385-treated rats. Mesenteric vascular injury was frequently associated with activation of mast cells (MC), endothelial cells (EC), and macrophages (MØ). Immunohistochemical studies showed increases in CD63 immunoreactivity of mesenteric MC and in nitrotyrosine immunoreactivity of mesenteric EC and MØ. The present study also provides a morphological and cellular basis for evaluating candidate biomarkers of drug-induced vascular injury. JF - Toxicologic pathology AU - Zhang, Jun AU - Snyder, Ronald D AU - Herman, Eugene H AU - Knapton, Alan AU - Honchel, Ronald AU - Miller, Terry AU - Espandiari, Parvaneh AU - Goodsaid, Federico M AU - Rosenblum, Irwin Y AU - Hanig, Joseph P AU - Sistare, Frank D AU - Weaver, James L AD - Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. jun.zhang@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 827 EP - 839 VL - 36 IS - 6 KW - Cyclic N-Oxides KW - 0 KW - Phosphodiesterase 4 Inhibitors KW - Phosphodiesterase Inhibitors KW - Quinolines KW - SCH 351591 KW - Index Medicus KW - Pancreas -- pathology KW - Animals KW - Intestine, Small -- blood supply KW - Stomach -- blood supply KW - Kidney -- pathology KW - Mesenteric Arteries -- pathology KW - Rats KW - Stomach -- pathology KW - Rats, Sprague-Dawley KW - Pancreas -- blood supply KW - Kidney -- blood supply KW - Intestine, Small -- pathology KW - Immunohistochemistry KW - Statistics, Nonparametric KW - Quinolines -- toxicity KW - Vascular Diseases -- pathology KW - Vascular Diseases -- chemically induced KW - Phosphodiesterase Inhibitors -- toxicity KW - Cyclic N-Oxides -- toxicity KW - Blood Vessels -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69717086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Histopathology+of+vascular+injury+in+Sprague-Dawley+rats+treated+with+phosphodiesterase+IV+inhibitor+SCH+351591+or+SCH+534385.&rft.au=Zhang%2C+Jun%3BSnyder%2C+Ronald+D%3BHerman%2C+Eugene+H%3BKnapton%2C+Alan%3BHonchel%2C+Ronald%3BMiller%2C+Terry%3BEspandiari%2C+Parvaneh%3BGoodsaid%2C+Federico+M%3BRosenblum%2C+Irwin+Y%3BHanig%2C+Joseph+P%3BSistare%2C+Frank+D%3BWeaver%2C+James+L&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2008-10-01&rft.volume=36&rft.issue=6&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308322308 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-11 N1 - Date created - 2008-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623308322308 ER - TY - JOUR T1 - Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385. AN - 69713474; 18776166 AB - Drug-associated vascular injury can be caused by phosphodiesterase (PDE) IV inhibitors and drugs from several other classes. The pathogenesis is poorly understood, but it appears to include vascular and innate immunological components. This research was undertaken to identify changes in peripheral blood associated with vascular injury caused by PDE IV inhibitors. We evaluated twelve proteins, serum nitrite, and leukocyte populations in peripheral blood of rats treated with experimental PDE IV inhibitors. We found that these compounds produced histological microvascular injury in a dose- and time-dependent manner. Measurement of these serum proteins showed changes in eight of the twelve examined. Changes were seen in the levels of: tissue inhibitor of metalloproteinase-1, alpha1-acid glycoprotein, GRO/CINC-1, vascular endothelial growth factor, C-reactive protein, haptoglobin, thrombomodulin, and interleukin-6. No changes were seen in levels of tumor necrosis factor-alpha, hepatocyte growth factor, nerve growth factor, and granulocyte-monocyte colony stimulating factor. Serum levels of nitrite were also increased. Circulating granulocyte numbers were increased, and lymphocyte numbers were decreased. The changes in these parameters showed both a dose- and time-dependent association with histopathologic changes. These biomarkers could provide an additional tool for the nonclinical and clinical evaluation of investigational compounds. JF - Toxicologic pathology AU - Weaver, James L AU - Snyder, Ronald AU - Knapton, Alan AU - Herman, Eugene H AU - Honchel, Ronald AU - Miller, Terry AU - Espandiari, Parvaneh AU - Smith, Roger AU - Gu, Yi-Zhong AU - Goodsaid, Federico M AU - Rosenblum, Irwin Y AU - Sistare, Frank D AU - Zhang, Jun AU - Hanig, Joseph AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. james.weaver@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 840 EP - 849 VL - 36 IS - 6 KW - Biomarkers KW - 0 KW - Cyclic N-Oxides KW - Nitrates KW - Nitrites KW - Phosphodiesterase 4 Inhibitors KW - Phosphodiesterase Inhibitors KW - Quinolines KW - SCH 351591 KW - Index Medicus KW - Rats KW - Nitrites -- blood KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Clinical Chemistry Tests KW - Mesenteric Arteries -- pathology KW - Immunohistochemistry KW - Leukocyte Count KW - Nitrates -- blood KW - Quinolines -- toxicity KW - Vascular Diseases -- pathology KW - Vascular Diseases -- chemically induced KW - Vascular Diseases -- blood KW - Phosphodiesterase Inhibitors -- toxicity KW - Cyclic N-Oxides -- toxicity KW - Blood Vessels -- drug effects KW - Biomarkers -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69713474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Biomarkers+in+peripheral+blood+associated+with+vascular+injury+in+Sprague-Dawley+rats+treated+with+the+phosphodiesterase+IV+inhibitors+SCH+351591+or+SCH+534385.&rft.au=Weaver%2C+James+L%3BSnyder%2C+Ronald%3BKnapton%2C+Alan%3BHerman%2C+Eugene+H%3BHonchel%2C+Ronald%3BMiller%2C+Terry%3BEspandiari%2C+Parvaneh%3BSmith%2C+Roger%3BGu%2C+Yi-Zhong%3BGoodsaid%2C+Federico+M%3BRosenblum%2C+Irwin+Y%3BSistare%2C+Frank+D%3BZhang%2C+Jun%3BHanig%2C+Joseph&rft.aulast=Weaver&rft.aufirst=James&rft.date=2008-10-01&rft.volume=36&rft.issue=6&rft.spage=840&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308322310 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-11 N1 - Date created - 2008-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623308322310 ER - TY - JOUR T1 - FDA drug approval summary: lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2. AN - 69711997; 18849320 AB - On March 13, 2007, the U.S. Food and Drug Administration approved lapatinib (Tykerb tablets; GlaxoSmithKline, Philadelphia), an oral, small molecule, dual tyrosine kinase inhibitor of ErbB-2 and ErbB-1, for use in combination with capecitabine for the treatment of patients with human epidermal growth factor receptor (HER)-2-overexpressing metastatic breast cancer who had received prior therapy including an anthracycline, a taxane, and trastuzumab. One multicenter, open-label, randomized trial was submitted. Eligible patients had stage IIIb or IV breast cancer, ErbB-2 overexpression (immunohistochemistry 3+ or 2+ with fluorescence in situ hybridization confirmation), measurable disease, a 0 or 1 Eastern Cooperative Oncology Group performance status score, a cardiac ejection fraction within the institutional normal range, and adequate laboratory function. Patients received either lapatinib (1,250 mg once daily on days 1-21) plus capecitabine (1,000 mg/m(2) every 12 hours on days 1-14) every 21 days or capecitabine alone (1,250 mg/m(2) every 12 hours on days 1-14) every 21 days. The primary endpoint was time to progression (TTP) determined by a blinded independent review panel. After TTP results of a prespecified interim analysis were made available, study enrollment was discontinued (399 patients enrolled). The median TTP was 27.1 versus 18.6 weeks (hazard ratio, 0.57; p = .00013) favoring the lapatinib plus capecitabine arm. Response rates were 23.7% (lapatinib plus capecitabine) versus 13.9% (capecitabine alone). Survival data were not mature. Although the toxicities observed in the lapatinib and capecitabine combination arm were generally similar to those in the capecitabine alone arm, a higher incidence of diarrhea and rash was noted with the combination. Grade 3 or 4 adverse reactions that occurred with a frequency of >5% in patients on the combination arm were diarrhea (13%) and palmar-plantar erythrodysesthesia (12%). There was a 2% incidence of reversible decreased left ventricular function in the combination arm. JF - The oncologist AU - Ryan, Qin AU - Ibrahim, Amna AU - Cohen, Martin H AU - Johnson, John AU - Ko, Chia-wen AU - Sridhara, Rajeshwari AU - Justice, Robert AU - Pazdur, Richard AD - Division of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. qin.ryan@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1114 EP - 1119 VL - 13 IS - 10 KW - Quinazolines KW - 0 KW - lapatinib KW - 0VUA21238F KW - Deoxycytidine KW - 0W860991D6 KW - Capecitabine KW - 6804DJ8Z9U KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - United States KW - Young Adult KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Disease Progression KW - Aged KW - Drug Resistance, Neoplasm KW - Quinazolines -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- adverse effects KW - United States Food and Drug Administration KW - Deoxycytidine -- adverse effects KW - Aged, 80 and over KW - Drug Approval KW - Fluorouracil -- analogs & derivatives KW - Adult KW - Neoplasm Metastasis KW - Deoxycytidine -- administration & dosage KW - Middle Aged KW - Quinazolines -- adverse effects KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Receptor, ErbB-2 -- antagonists & inhibitors KW - Breast Neoplasms -- enzymology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Receptor, ErbB-2 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69711997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+drug+approval+summary%3A+lapatinib+in+combination+with+capecitabine+for+previously+treated+metastatic+breast+cancer+that+overexpresses+HER-2.&rft.au=Ryan%2C+Qin%3BIbrahim%2C+Amna%3BCohen%2C+Martin+H%3BJohnson%2C+John%3BKo%2C+Chia-wen%3BSridhara%2C+Rajeshwari%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Ryan&rft.aufirst=Qin&rft.date=2008-10-01&rft.volume=13&rft.issue=10&rft.spage=1114&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2008-0816 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-25 N1 - Date created - 2008-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2008-0816 ER - TY - JOUR T1 - Lenalidomide in combination with dexamethasone for the treatment of multiple myeloma after one prior therapy. AN - 69708087; 18922829 AB - Lenalidomide (CC-5013, Revlimid; Celgene Corporation, Summit, NJ), a thalidomide analogue, was granted approval by the U.S. Food and Drug Administration (FDA) on June 29, 2006, for use in combination with dexamethasone in patients with multiple myeloma (MM) who have received at least one prior therapy. The FDA approved lenalidomide with a restricted distribution program, RevAssist. In two randomized, double-blind, multicenter studies, the combination of lenalidomide and dexamethasone (LD) was compared with placebo and dexamethasone (PD) in patients with MM who had received at least one prior therapy. The primary endpoint was time to progression (TTP). Following a prespecified interim analysis of TTP, an independent data-monitoring committee advised the sponsor to halt the two studies. For both studies, the interim analysis for efficacy revealed a statistically significant longer TTP with LD than with PD. The most clinically relevant grade 3 and 4 adverse events that occurred more frequently in the LD arm were neutropenia, thrombocytopenia, deep vein thrombosis, pulmonary embolism, and atrial fibrillation. Thrombotic or thromboembolic events, including deep vein thrombosis, pulmonary embolism, thrombosis, and intracranial venous sinus thrombosis were reported more frequently in patients treated with LD than with PD. The FDA approved lenalidomide based on interim results from two multicenter, placebo-controlled, randomized trials comparing the combination of LD with PD that revealed a longer TTP with LD than with PD. The major toxicity observed during these trials was myelosuppression. The serious toxicities included thromboembolic events. Lenalidomide is only available under the RevAssist Program. JF - The oncologist AU - Hazarika, Maitreyee AU - Rock, Edwin AU - Williams, Gene AU - Dagher, Ramzi AU - Sridhara, Rajeshwari AU - Booth, Brian AU - Farrell, Ann AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1120 EP - 1127 VL - 13 IS - 10 KW - Placebos KW - 0 KW - Thalidomide KW - 4Z8R6ORS6L KW - Dexamethasone KW - 7S5I7G3JQL KW - lenalidomide KW - F0P408N6V4 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Thalidomide -- adverse effects KW - Double-Blind Method KW - Aged, 80 and over KW - Humans KW - Drug Approval KW - Disease Progression KW - Aged KW - Thalidomide -- administration & dosage KW - Middle Aged KW - Male KW - Female KW - Thalidomide -- analogs & derivatives KW - Dexamethasone -- therapeutic use KW - Dexamethasone -- adverse effects KW - Multiple Myeloma -- drug therapy KW - Dexamethasone -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69708087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Lenalidomide+in+combination+with+dexamethasone+for+the+treatment+of+multiple+myeloma+after+one+prior+therapy.&rft.au=Hazarika%2C+Maitreyee%3BRock%2C+Edwin%3BWilliams%2C+Gene%3BDagher%2C+Ramzi%3BSridhara%2C+Rajeshwari%3BBooth%2C+Brian%3BFarrell%2C+Ann%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Hazarika&rft.aufirst=Maitreyee&rft.date=2008-10-01&rft.volume=13&rft.issue=10&rft.spage=1120&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2008-0077 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-25 N1 - Date created - 2008-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2008-0077 ER - TY - JOUR T1 - Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study. AN - 69685576; 18774129 AB - Concern about potential health impacts of low-level exposures to organophosphorus (OP) pesticides, bisphenol A (BPA), and phthalates among the general population is increasing. We measured levels of six dialkyl phosphate (DAP) metabolites of OP pesticides, a chlorpyrifos-specific metabolite (3,5,6-trichloro-2-pyridinol, TCPy), BPA, and 14 phthalate metabolites in urine samples of 100 pregnant women from the Generation R study, the Netherlands. The unadjusted and creatinine-adjusted concentrations were reported, and compared to National Health and Nutrition Examination Survey and other studies. In general, these metabolites were detectable in the urine of the women from the Generation R study and compared with other groups, they had relatively high-level exposures to OP pesticides and several phthalates but similar exposure to BPA. The median concentrations of total dimethyl (DM) metabolites was 264.0 n mol/g creatinine (Cr) and of total DAP was 316.0 n mol/g Cr. The median concentration of mono-ethyl phthalate (MEP) was 222.0 microg/g Cr; the median concentrations of mono-isobutyl phthalate (MiBP) and mono-n-butyl phthalate (MnBP) were above 50 microg/g Cr. The median concentrations of the three secondary metabolites of di-2-ethylhexyl phthalate (DEHP) were greater than 20 microg/g Cr. The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation. JF - Environmental research AU - Ye, Xibiao AU - Pierik, Frank H AU - Hauser, Russ AU - Duty, Susan AU - Angerer, Jürgen AU - Park, Melissa M AU - Burdorf, Alex AU - Hofman, Albert AU - Jaddoe, Vincent W V AU - Mackenbach, Johan P AU - Steegers, Eric A P AU - Tiemeier, Henning AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3-05, PO Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 260 EP - 267 VL - 108 IS - 2 KW - Benzhydryl Compounds KW - 0 KW - Environmental Pollutants KW - Organophosphorus Compounds KW - Pesticides KW - Phenols KW - Phthalic Acids KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Cities KW - Humans KW - Gestational Age KW - Cohort Studies KW - Adult KW - Gas Chromatography-Mass Spectrometry KW - Tandem Mass Spectrometry KW - Netherlands KW - Adolescent KW - Female KW - Pregnancy KW - Pesticides -- metabolism KW - Organophosphorus Compounds -- urine KW - Environmental Pollutants -- metabolism KW - Organophosphorus Compounds -- metabolism KW - Phenols -- metabolism KW - Pesticides -- urine KW - Phthalic Acids -- metabolism KW - Environmental Pollutants -- urine KW - Phenols -- urine KW - Phthalic Acids -- urine KW - Maternal Exposure KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69685576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Urinary+metabolite+concentrations+of+organophosphorous+pesticides%2C+bisphenol+A%2C+and+phthalates+among+pregnant+women+in+Rotterdam%2C+the+Netherlands%3A+the+Generation+R+study.&rft.au=Ye%2C+Xibiao%3BPierik%2C+Frank+H%3BHauser%2C+Russ%3BDuty%2C+Susan%3BAngerer%2C+J%C3%BCrgen%3BPark%2C+Melissa+M%3BBurdorf%2C+Alex%3BHofman%2C+Albert%3BJaddoe%2C+Vincent+W+V%3BMackenbach%2C+Johan+P%3BSteegers%2C+Eric+A+P%3BTiemeier%2C+Henning%3BLongnecker%2C+Matthew+P&rft.aulast=Ye&rft.aufirst=Xibiao&rft.date=2008-10-01&rft.volume=108&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2008.07.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-12 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):269-80 [15664359] Int J Hyg Environ Health. 2004 Oct;207(5):409-17 [15575555] Environ Health Perspect. 2005 Aug;113(8):1056-61 [16079079] Clin Chim Acta. 2005 Nov;361(1-2):20-9 [16004980] Occup Environ Med. 2005 Nov;62(11):806-18 [16234408] Environ Health Perspect. 2005 Dec;113(12):1802-7 [16330368] Environ Health Perspect. 2006 Feb;114(2):260-3 [16451864] Int J Androl. 2006 Feb;29(1):134-9; discussion 181-5 [16466533] Int J Androl. 2006 Feb;29(1):155-65; discussion 181-5 [16466535] Environ Health Perspect. 2006 Jun;114(6):805-9 [16759976] Environ Health Perspect. 2006 Aug;114(8):1158-61 [16882519] Eur J Epidemiol. 2006;21(6):475-84 [16826450] Toxicology. 2006 Sep 21;226(2-3):79-89 [16860916] Environ Mol Mutagen. 2006 Oct;47(8):571-8 [16795089] Environ Health Perspect. 2006 Nov;114(11):1763-9 [17107865] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2006;24(2):225-55 [17114111] Int J Hyg Environ Health. 2007 Jan;210(1):21-33 [17182278] Pediatr Res. 2007 Feb;61(2):243-50 [17237730] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Mar 1;847(2):114-25 [17055785] Int J Hyg Environ Health. 2007 May;210(3-4):319-33 [17400024] Environ Health Perspect. 2007 May;115(5):792-8 [17520070] Am J Epidemiol. 2007 Jun 15;165(12):1397-404 [17406008] Reprod Toxicol. 2007 Aug-Sep;24(2):131-8 [17768031] Hum Reprod. 2007 Oct;22(10):2715-22 [17704099] Eur J Epidemiol. 2007;22(12):917-23 [18095172] J Chromatogr B Biomed Sci Appl. 2001 Aug 5;759(1):43-9 [11499628] J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Oct 5;778(1-2):5-29 [12376114] Reprod Toxicol. 2002 Sep-Oct;16(5):721-34 [12406498] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jan 25;784(1):169-82 [12504195] Environ Health Perspect. 2003 Jan;111(1):79-84 [12515682] Regul Toxicol Pharmacol. 2003 Jun;37(3):382-95 [12758218] Environ Health Perspect. 2003 Jul;111(9):1148-51 [12842765] Environ Res. 2003 Oct;93(2):177-85 [12963402] Environ Health Perspect. 2003 Nov;111(14):1719-22 [14594621] Environ Health Perspect. 2003 Dec;111(16):1939-46 [14644670] Environ Health Perspect. 2004 Feb;112(2):186-200 [14754573] Environ Health Perspect. 2004 Mar;112(3):331-8 [14998749] J Expo Anal Environ Epidemiol. 2004 May;14(3):249-59 [15141154] Clin Chim Acta. 1972 May;38(2):475-6 [5026368] Environ Health Perspect. 1982 Nov;45:11-7 [7140682] Kidney Int. 1989 Jul;36(1):108-13 [2811052] Am Ind Hyg Assoc J. 1993 Oct;54(10):615-27 [8237794] J Expo Anal Environ Epidemiol. 2005 Jul;15(4):297-309 [15367928] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.envres.2008.07.014 ER - TY - JOUR T1 - Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats. AN - 69682432; 18843197 AB - The members of the platelet-derived growth factor (PDGF) and the transforming growth factor-beta (TGFbeta) pathways are important in the induction of liver fibrosis and cirrhosis; however, their role in the subsequent progression to hepatocellular carcinoma (HCC) remains elusive. Our study provides new insights into mechanisms of dysregulation of PDGFs, TGFbeta and signal transducer and activator of transcription (STAT) pathways in the pathogenesis of methyl-deficient rodent liver carcinogenesis, a remarkably relevant model to the development of HCC in humans. We demonstrated a progressive increase in the Pdgfs and TGFbeta expression in preneoplastic tissue and liver tumors indicating their promotional role in carcinogenesis, particularly in progression of liver fibrosis and cirrhosis. However, activation of the STAT3 occurred only in fully developed HCC and was associated with downregulation of the Socs1 gene. The inhibition of the Socs1 expression in HCC was associated with an increase in histone H3 lysine 9, H3 lysine 27, and H4 lysine 20 trimethylation at the Socs1 promoter, but not with promoter methylation. The results of our study suggest the following model of events in hepatocarcinogenesis: during early stages, overexpression of the Socs1 effectively inhibits TGFbeta- and PDGF-induced STAT3 activation, whereas, during the advanced stages of hepatocarcinogenesis, the Socs1 downregulation resulted in loss of its ability to attenuate the signal from the upregulated TGFbeta and PDGFs leading to oncogenic STAT3 activation and malignant cell transformation. This model illustrates that the Socs1 acts as classic tumor suppressor by preventing activation of the STAT3 and downregulation of Socs1 and consequent activation of STAT3 may be a crucial events leading to formation of HCC. JF - Cell cycle (Georgetown, Tex.) AU - Bagnyukova, Tetyana V AU - Tryndyak, Volodymyr P AU - Muskhelishvili, Levan AU - Ross, Sharon A AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 3202 EP - 3210 VL - 7 IS - 20 KW - Platelet-Derived Growth Factor KW - 0 KW - STAT3 Transcription Factor KW - Socs1 protein, rat KW - Stat3 protein, rat KW - Suppressor of Cytokine Signaling 1 Protein KW - Suppressor of Cytokine Signaling Proteins KW - Transforming Growth Factor beta KW - Methionine KW - AE28F7PNPL KW - Receptors, Platelet-Derived Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Receptors, Platelet-Derived Growth Factor -- metabolism KW - Animals KW - Platelet-Derived Growth Factor -- metabolism KW - Liver -- pathology KW - Random Allocation KW - Humans KW - Liver -- metabolism KW - Platelet-Derived Growth Factor -- genetics KW - Receptors, Platelet-Derived Growth Factor -- genetics KW - Rats KW - Signal Transduction -- physiology KW - Rats, Inbred F344 KW - Promoter Regions, Genetic KW - Down-Regulation KW - Gene Expression Regulation KW - Diet KW - Transforming Growth Factor beta -- genetics KW - Transforming Growth Factor beta -- metabolism KW - Methylation KW - Male KW - Suppressor of Cytokine Signaling Proteins -- metabolism KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Methionine -- deficiency KW - STAT3 Transcription Factor -- genetics KW - Suppressor of Cytokine Signaling Proteins -- genetics KW - STAT3 Transcription Factor -- metabolism KW - Epigenesis, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69682432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=Epigenetic+downregulation+of+the+suppressor+of+cytokine+signaling+1+%28Socs1%29+gene+is+associated+with+the+STAT3+activation+and+development+of+hepatocellular+carcinoma+induced+by+methyl-deficiency+in+rats.&rft.au=Bagnyukova%2C+Tetyana+V%3BTryndyak%2C+Volodymyr+P%3BMuskhelishvili%2C+Levan%3BRoss%2C+Sharon+A%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Bagnyukova&rft.aufirst=Tetyana&rft.date=2008-10-01&rft.volume=7&rft.issue=20&rft.spage=3202&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-24 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat. AN - 69653742; 18626999 AB - The product of the phosphatidylinositol glycan complementation group A gene (Pig-A) is involved in the synthesis of glycosylphosphatidylinositol (GPI) anchors that link various protein markers to the surface of several types of mammalian cells, including hematopoietic cells. Previous observations indicate that Pig-A mutation results in the lack of GPI synthesis and the absence of GPI-anchored proteins on the cell surface. As a first step in designing a rapid assay for measuring Pig-A mutation in the rat, we developed flow cytometry (FCM) strategies for detecting GPI-negative cells in rat peripheral blood and spleen. Anti-CD59 was used to detect GPI-anchored proteins on red blood cells (RBCs), and anti-CD48 was used to detect GPI-anchored proteins on spleen T-cells. The spontaneous frequency of CD59-negative RBCs in five male F344 rats ranged from 1 x 10(-6) to 27 x 10(-6). In contrast, treatment of five rats with three doses of 40 mg/kg N-ethyl-N-nitrosourea (ENU) increased the frequency of CD59-negative RBCs to 183 x 10(-6) to 249 x 10(-6) at 2 weeks and to 329 x 10(-6) to 413 x 10(-6) at 4 weeks after dosing. In the same 4-week posttreatment rats, the frequency of CD48-negative T-cells was 11 x 10(-6) to 16 x 10(-6) in control rats and 194 x 10(-6) to 473 x 10(-6) in ENU-treated rats. The frequencies of GPI-deficient cells were similar for RBCs and spleen T-cells. These results indicate that FCM detection of GPI-linked markers may form the basis for a rapid in vivo mutation assay. Although RBCs may be useful for a minimally invasive assay, T-cells are a promising tissue for both detecting GPI-deficient cells and confirming that Pig-A gene mutation is the cause of the phenotype. Published 2008 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Miura, Daishiro AU - Dobrovolsky, Vasily N AU - Kasahara, Yoshinori AU - Katsuura, Yasuhiro AU - Heflich, Robert H AD - Division of Genetic and Reproductive Toxicology, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 614 EP - 621 VL - 49 IS - 8 KW - Antigens, CD KW - 0 KW - Antigens, CD59 KW - CD48 Antigen KW - Cd48 protein, rat KW - Glycosylphosphatidylinositols KW - Membrane Proteins KW - Mutagens KW - phosphatidylinositol glycan-class A protein KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Ethylnitrosourea -- toxicity KW - Mutagens -- toxicity KW - Male KW - Mutagenicity Tests KW - Spleen -- cytology KW - Membrane Proteins -- genetics KW - Antigens, CD59 -- blood KW - T-Lymphocytes -- immunology KW - Erythrocytes -- immunology KW - Antigens, CD -- immunology KW - Flow Cytometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69653742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Development+of+an+in+vivo+gene+mutation+assay+using+the+endogenous+Pig-A+gene%3A+I.+Flow+cytometric+detection+of+CD59-negative+peripheral+red+blood+cells+and+CD48-negative+spleen+T-cells+from+the+rat.&rft.au=Miura%2C+Daishiro%3BDobrovolsky%2C+Vasily+N%3BKasahara%2C+Yoshinori%3BKatsuura%2C+Yasuhiro%3BHeflich%2C+Robert+H&rft.aulast=Miura&rft.aufirst=Daishiro&rft.date=2008-10-01&rft.volume=49&rft.issue=8&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20414 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-28 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20414 ER - TY - JOUR T1 - Development of an in vivo gene mutation assay using the endogenous Pig-A gene: II. Selection of Pig-A mutant rat spleen T-cells with proaerolysin and sequencing Pig-A cDNA from the mutants. AN - 69653688; 18626996 AB - We previously reported that rat spleen T-cells and peripheral red blood cells that are deficient in glycosylphosphatidylinositol (GPI) synthesis [presumed mutants for the phosphatidylinositol glycan complementation group A gene (Pig-A)] could be detected by flow cytometry (FCM) as cells negative for GPI-linked markers (CD48 and CD59, respectively). To establish this procedure as a rapid in vivo gene mutation assay, we have examined the Pig-A gene of GPI-deficient rat spleen T-cells for DNA sequence alterations. Splenocytes were isolated from male F344 rats, primed with ionomycin and phorbol-12-myristate-13-acetate, and seeded at limiting-dilution into 96-well plates. To select for GPI-deficient T-cells, the cells were cultured for 10 days in a medium containing rat T-STIM and 2 nM proaerolysin (ProAER). The frequency of ProAER-resistant (ProAER(r)) spleen T-cells from control rats ranged from 1.3 x 10(-6) to 4.8 x 10(-6), while administration of three doses of 40 mg/kg N-ethyl-N-nitrosourea increased the frequency of ProAER(r) T-cells 100-fold at 4 weeks after dosing. FCM analysis of the cells in ProAER(r) clones revealed that they were CD48-negative, and thus presumably GPI-deficient. Sequencing of Pig-A cDNA from six ProAER(r) clones indicated that they all contained alterations in the Pig-A protein coding sequence; five had base pair substitutions and one had multiple exons deleted. These results indicate that GPI-deficient spleen T-cells are Pig-A gene mutants and support the use of FCM analysis of GPI-deficient cells as a rapid assay for measuring in vivo gene mutation. Published 2008 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Miura, Daishiro AU - Dobrovolsky, Vasily N AU - Mittelstaedt, Roberta A AU - Kasahara, Yoshinori AU - Katsuura, Yasuhiro AU - Heflich, Robert H AD - Division of Genetic and Reproductive Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 622 EP - 630 VL - 49 IS - 8 KW - Bacterial Toxins KW - 0 KW - DNA Primers KW - DNA, Complementary KW - Membrane Proteins KW - Pore Forming Cytotoxic Proteins KW - phosphatidylinositol glycan-class A protein KW - proaerolysin KW - Index Medicus KW - Rats KW - Animals KW - Base Sequence KW - Cells, Cultured KW - Flow Cytometry KW - Reverse Transcriptase Polymerase Chain Reaction KW - Pore Forming Cytotoxic Proteins -- toxicity KW - DNA, Complementary -- genetics KW - Spleen -- cytology KW - Bacterial Toxins -- toxicity KW - T-Lymphocytes -- drug effects KW - Membrane Proteins -- genetics KW - Spleen -- drug effects KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69653688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Development+of+an+in+vivo+gene+mutation+assay+using+the+endogenous+Pig-A+gene%3A+II.+Selection+of+Pig-A+mutant+rat+spleen+T-cells+with+proaerolysin+and+sequencing+Pig-A+cDNA+from+the+mutants.&rft.au=Miura%2C+Daishiro%3BDobrovolsky%2C+Vasily+N%3BMittelstaedt%2C+Roberta+A%3BKasahara%2C+Yoshinori%3BKatsuura%2C+Yasuhiro%3BHeflich%2C+Robert+H&rft.aulast=Miura&rft.aufirst=Daishiro&rft.date=2008-10-01&rft.volume=49&rft.issue=8&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20413 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-28 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20413 ER - TY - JOUR T1 - Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice. AN - 69652703; 18618596 AB - Methylphenidate hydrochloride (MPH) is one of the most frequently prescribed pediatric drugs for the treatment of attention deficit hyperactivity disorder. In a recent study, increased hepatic adenomas were observed in B6C3F1 mice treated with MPH in their diet. To evaluate the reactive metabolite, ritalinic acid (RA) of MPH and its mode of action in mice, we conducted extensive investigations on the pharmacokinetics (PK) and genotoxicity of the drug in B6C3F1 mice. For the PK study, male B6C3F1 mice were gavaged once with 3 mg/kg body weight (BW) of MPH and groups of mice were sacrificed at various time points (0.25-24 hr) for serum analysis of MPH and RA concentrations. Groups of male B6C3F1 mice were fed diets containing 0, 250, 500, 1,000, 2,000, or 4,000 ppm of MPH for 28 days to determine the appropriate doses for 24-week transgenic mutation studies. Also, the micronucleus frequencies (MN-RETs and MN-NCEs), and the lymphocyte Hprt mutants were determined in peripheral blood and splenic lymphocytes, respectively. Mice fed 4,000 ppm of MPH lost significant BW compared to control mice (P < 0.01). There was a significant increase in the average liver weights whereas kidneys, seminal vesicle, testes, thymus, and urinary bladder weights of mice fed higher doses of MPH were significantly lower than the control group (P < or = 0.05). There was no significant increase in either the Hprt mutant frequency or the micronucleus frequency in the treated animals. These results indicated that although MPH induced liver hypertrophy in mice, no genotoxicity was observed. Published 2008 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Manjanatha, Mugimane G AU - Shelton, Sharon D AU - Dobrovolsky, Vasily N AU - Shaddock, Joseph G AU - McGarrity, Lynda G AU - Doerge, Daniel R AU - Twaddle, Nathan W AU - Lin, Chien-Ju AU - Chen, James J AU - Mattison, Donald R AU - Morris, Suzanne M AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. mugimane.manjanatha@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 585 EP - 593 VL - 49 IS - 8 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - ritalinic acid KW - GT4165RS9H KW - Index Medicus KW - Spectrometry, Mass, Electrospray Ionization KW - Animals KW - Liver -- enzymology KW - Liver -- pathology KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - Dose-Response Relationship, Drug KW - Mice KW - Mutagenicity Tests KW - Liver -- drug effects KW - Body Weight -- drug effects KW - Chromatography, Liquid KW - Feeding Behavior -- drug effects KW - Male KW - Organ Size -- drug effects KW - Methylphenidate -- administration & dosage KW - Methylphenidate -- pharmacokinetics KW - Methylphenidate -- toxicity KW - Methylphenidate -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69652703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Pharmacokinetics%2C+dose-range%2C+and+mutagenicity+studies+of+methylphenidate+hydrochloride+in+B6C3F1+mice.&rft.au=Manjanatha%2C+Mugimane+G%3BShelton%2C+Sharon+D%3BDobrovolsky%2C+Vasily+N%3BShaddock%2C+Joseph+G%3BMcGarrity%2C+Lynda+G%3BDoerge%2C+Daniel+R%3BTwaddle%2C+Nathan+W%3BLin%2C+Chien-Ju%3BChen%2C+James+J%3BMattison%2C+Donald+R%3BMorris%2C+Suzanne+M&rft.aulast=Manjanatha&rft.aufirst=Mugimane&rft.date=2008-10-01&rft.volume=49&rft.issue=8&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20407 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-28 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20407 ER - TY - JOUR T1 - A framework for the concurrent consideration of occupational hazards and obesity. AN - 69642908; 18765399 AB - Occupational hazards and obesity can lead to extensive morbidity and mortality and put great financial burden on society. Historically, occupational hazards and obesity have been addressed as separate unrelated issues, but both are public health problems and there may be public health benefits from considering them together. This paper provides a framework for the concurrent consideration of occupational hazards and obesity. The framework consists of the following elements: (i) investigate the relationship between occupational hazards and obesity, (ii) explore the impact of occupational morbidity and mortality and obesity on workplace absence, disability, productivity and healthcare costs, (iii) assess the utility of the workplace as a venue for obesity prevention programs, (iv) promote a comprehensive approach to worker health and (v) identify and address the ethical, legal and social issues. Utilizing this framework may advance the efforts to address the major societal health problems of occupational hazards and obesity. JF - The Annals of occupational hygiene AU - Schulte, P A AU - Wagner, G R AU - Downes, A AU - Miller, D B AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-C14, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 555 EP - 566 VL - 52 IS - 7 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Health KW - Obesity -- prevention & control KW - Obesity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69642908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=A+framework+for+the+concurrent+consideration+of+occupational+hazards+and+obesity.&rft.au=Schulte%2C+P+A%3BWagner%2C+G+R%3BDownes%2C+A%3BMiller%2C+D+B&rft.aulast=Schulte&rft.aufirst=P&rft.date=2008-10-01&rft.volume=52&rft.issue=7&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmen055 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-22 N1 - Date created - 2008-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/men055 ER - TY - JOUR T1 - Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes. AN - 69624663; 18632753 AB - Aromatic amines (AAs) and polycyclic aromatic hydrocarbons (PAHs) are carcinogens present in tobacco smoke and functional polymorphisms in NAT2 and GSTM1 metabolizing genes are associated with increased bladder cancer risk. We evaluated whether genetic variation in other candidate metabolizing genes are also associated with risk. Candidates included genes that control the transcription of metabolizing genes [aryl hydrocarbon receptor (AHR), AHRR and aryl hydrocarbon nuclear translocator (ARNT)] and genes that activate/detoxify AA or PAH (AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX1, EPHX2, NQO1, MPO, UGT1A4, SULT1A1 and SULT1A2). Using genotype data from 1150 cases of urothelial carcinomas and 1149 controls from the Spanish Bladder Cancer Study, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) adjusting for age, gender, region and smoking status. Based on a test for trend, we observed 10 non-redundant single-nucleotide polymorphisms (SNPs) in five genes (AKR1C3, ARNT, CYP1A1, CYP1B1 and SULT1A2) significantly associated with bladder cancer risk. We observed an inverse association with risk for the AKR1C3 promoter SNP rs1937845 [OR (95% CI) for heterozygote and homozygote variant compared with common homozygote genotype were 0.86 (0.70-1.06) and 0.74 (0.57-0.96), respectively; P for trend = 0.02]. Interestingly, genetic variation in this region has been associated with lung, non-Hodgkin lymphoma and prostate cancer risk. Analysis of additional SNPs to capture most (approximately 90%) of common genetic variation in AKR1C3 and haplotype walking analyses based on all AKR1C3 SNPs (n = 25) suggest two separate regions associated with bladder cancer risk. These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk. JF - Carcinogenesis AU - Figueroa, Jonine D AU - Malats, Núria AU - García-Closas, Montserrat AU - Real, Francisco X AU - Silverman, Debra AU - Kogevinas, Manolis AU - Chanock, Stephen AU - Welch, Robert AU - Dosemeci, Mustafa AU - Lan, Qing AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Castaño-Vinyals, Gemma AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. figueroaj@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1955 EP - 1962 VL - 29 IS - 10 KW - ARNT protein, human KW - 0 KW - Aryl Hydrocarbon Receptor Nuclear Translocator KW - 138391-32-9 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - 3-Hydroxysteroid Dehydrogenases KW - EC 1.1.- KW - AKR1C3 protein, human KW - EC 1.1.1.- KW - Hydroxyprostaglandin Dehydrogenases KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1B1 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Genetic Variation KW - Cytochrome P-450 CYP1A1 -- genetics KW - Cytochrome P-450 Enzyme System -- genetics KW - Humans KW - Aged KW - Glutathione Transferase -- genetics KW - Genotype KW - Promoter Regions, Genetic KW - Haplotypes KW - Aged, 80 and over KW - Aryl Hydrocarbon Receptor Nuclear Translocator -- genetics KW - Risk Factors KW - Adult KW - Middle Aged KW - Male KW - Female KW - Polymorphism, Single Nucleotide KW - Urinary Bladder Neoplasms -- etiology KW - 3-Hydroxysteroid Dehydrogenases -- genetics KW - Hydroxyprostaglandin Dehydrogenases -- genetics KW - Urinary Bladder Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69624663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Bladder+cancer+risk+and+genetic+variation+in+AKR1C3+and+other+metabolizing+genes.&rft.au=Figueroa%2C+Jonine+D%3BMalats%2C+N%C3%BAria%3BGarc%C3%ADa-Closas%2C+Montserrat%3BReal%2C+Francisco+X%3BSilverman%2C+Debra%3BKogevinas%2C+Manolis%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BDosemeci%2C+Mustafa%3BLan%2C+Qing%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BCasta%C3%B1o-Vinyals%2C+Gemma%3BRothman%2C+Nathaniel&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2008-10-01&rft.volume=29&rft.issue=10&rft.spage=1955&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn163 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-14 N1 - Date created - 2008-10-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2000 Oct;83(8):998-1002 [10993645] Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):969-78 [17507624] Biochem J. 2000 Oct 1;351(Pt 1):67-77 [10998348] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] J Biol Chem. 2002 Jul 5;277(27):24799-808 [11978787] Mutat Res. 2002 Sep 30;506-507:29-40 [12351142] Mutat Res. 2002 Sep 30;506-507:65-77 [12351146] Carcinogenesis. 2002 Nov;23(11):1839-49 [12419832] Cancer Lett. 2003 Dec 8;202(1):61-9 [14643027] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] World J Urol. 2004 Feb;21(6):382-91 [14648102] Curr Drug Metab. 2004 Jun;5(3):211-24 [15180491] Hematol Oncol Clin North Am. 1992 Feb;6(1):1-30 [1556044] Cancer Epidemiol Biomarkers Prev. 1992 Jan-Feb;1(2):149-53 [1306098] IARC Sci Publ. 1993;(124):331-40 [8225503] Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8413-7 [8078896] Oncol Res. 1994;6(10-11):525-32 [7620221] Br J Cancer. 1995 Sep;72(3):555-61 [7669561] Mutat Res. 1997 May 12;376(1-2):135-42 [9202749] Cancer Causes Control. 1997 May;8(3):346-55 [9498898] Cancer Causes Control. 1997 May;8(3):444-72 [9498904] J Biochem. 1998 Nov;124(5):940-6 [9792917] Toxicol Lett. 1998 Dec 28;102-103:173-83 [10022251] Pharmacogenetics. 1999 Feb;9(1):113-21 [10208650] Carcinogenesis. 2004 Nov;25(11):2177-81 [15284179] Genet Epidemiol. 2004 Dec;27(4):348-64 [15543638] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Nature. 2005 Oct 27;437(7063):1299-320 [16255080] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Pharmacogenomics J. 2007 Aug;7(4):282-9 [16983398] Arch Biochem Biophys. 2007 Aug 15;464(2):241-50 [17537398] Mutat Res. 2007 Dec 1;625(1-2):72-82 [17612574] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):979-87 [16702380] Nat Clin Pract Urol. 2006 Jun;3(6):327-40 [16763645] Toxicol Lett. 2006 Aug 20;165(2):182-94 [16713138] Expert Opin Drug Metab Toxicol. 2005 Aug;1(2):187-202 [16922636] Toxicol Lett. 2006 Dec 15;167(3):212-20 [17069994] PLoS Genet. 2007 Feb 23;3(2):e29 [17319747] Hum Genet. 2007 Apr;121(2):161-8 [17149600] Genet Epidemiol. 2000 Dec;19(4):323-32 [11108642] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn163 ER - TY - JOUR T1 - Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. AN - 69623489; 18658273 AB - Nanomaterials are frontier technological products used in different manufactured goods. Because of their unique physicochemical, electrical, mechanical, and thermal properties, single-walled carbon nanotubes (SWCNT) are finding numerous applications in electronics, aerospace devices, computers, and chemical, polymer, and pharmaceutical industries. SWCNT are relatively recently discovered members of the carbon allotropes that are similar in structure to fullerenes and graphite. Previously, we (47) have reported that pharyngeal aspiration of purified SWCNT by C57BL/6 mice caused dose-dependent granulomatous pneumonia, oxidative stress, acute inflammatory/cytokine responses, fibrosis, and decrease in pulmonary function. To avoid potential artifactual effects due to instillation/agglomeration associated with SWCNT, we conducted inhalation exposures using stable and uniform SWCNT dispersions obtained by a newly developed aerosolization technique (2). The inhalation of nonpurified SWCNT (iron content of 17.7% by weight) at 5 mg/m(3), 5 h/day for 4 days was compared with pharyngeal aspiration of varying doses (5-20 microg per mouse) of the same SWCNT. The chain of pathological events in both exposure routes was realized through synergized interactions of early inflammatory response and oxidative stress culminating in the development of multifocal granulomatous pneumonia and interstitial fibrosis. SWCNT inhalation was more effective than aspiration in causing inflammatory response, oxidative stress, collagen deposition, and fibrosis as well as mutations of K-ras gene locus in the lung of C57BL/6 mice. JF - American journal of physiology. Lung cellular and molecular physiology AU - Shvedova, A A AU - Kisin, E AU - Murray, A R AU - Johnson, V J AU - Gorelik, O AU - Arepalli, S AU - Hubbs, A F AU - Mercer, R R AU - Keohavong, P AU - Sussman, N AU - Jin, J AU - Yin, J AU - Stone, S AU - Chen, B T AU - Deye, G AU - Maynard, A AU - Castranova, V AU - Baron, P A AU - Kagan, V E AD - Health Effects Laboratory Div., National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. ats1@cdc.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - L552 EP - L565 VL - 295 IS - 4 SN - 1040-0605, 1040-0605 KW - Aerosols KW - 0 KW - Nanotubes, Carbon KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Carbon -- pharmacology KW - Animals KW - Pharynx KW - Aerosols -- administration & dosage KW - Fibrosis KW - Mice, Inbred C57BL KW - Mice KW - Female KW - Oxidative Stress -- drug effects KW - Lung -- drug effects KW - Inflammation -- etiology KW - Lung -- pathology KW - Administration, Inhalation KW - Nanotubes, Carbon -- adverse effects KW - Respiration Disorders -- chemically induced KW - Mutagenesis KW - Inflammation -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69623489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.atitle=Inhalation+vs.+aspiration+of+single-walled+carbon+nanotubes+in+C57BL%2F6+mice%3A+inflammation%2C+fibrosis%2C+oxidative+stress%2C+and+mutagenesis.&rft.au=Shvedova%2C+A+A%3BKisin%2C+E%3BMurray%2C+A+R%3BJohnson%2C+V+J%3BGorelik%2C+O%3BArepalli%2C+S%3BHubbs%2C+A+F%3BMercer%2C+R+R%3BKeohavong%2C+P%3BSussman%2C+N%3BJin%2C+J%3BYin%2C+J%3BStone%2C+S%3BChen%2C+B+T%3BDeye%2C+G%3BMaynard%2C+A%3BCastranova%2C+V%3BBaron%2C+P+A%3BKagan%2C+V+E&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2008-10-01&rft.volume=295&rft.issue=4&rft.spage=L552&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.issn=10400605&rft_id=info:doi/10.1152%2Fajplung.90287.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-10-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Crit Rev Toxicol. 2006 Mar;36(3):189-217 [16686422] J Nanosci Nanotechnol. 2006 Mar;6(3):591-9 [16573109] Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4 Suppl):3-10 [17291399] Br J Pharmacol. 2007 Mar;150(5):552-8 [17245366] Toxicol In Vitro. 2007 Apr;21(3):438-48 [17125965] Environ Health Perspect. 2007 Mar;115(3):377-82 [17431486] Environ Toxicol. 2007 Aug;22(4):415-21 [17607736] Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L87-97 [18024722] Expert Opin Drug Deliv. 2008 Mar;5(3):331-42 [18318654] Am J Respir Cell Mol Biol. 2008 May;38(5):579-90 [18096873] Inhal Toxicol. 2008 Jun;20(8):751-60 [18569097] Mol Cancer Ther. 2008 Jul;7(7):1913-22 [18645002] Environ Health Perspect. 2007 Aug;115(8):1125-31 [17687437] Am J Respir Crit Care Med. 2000 Jan;161(1):5-8 [10619790] Toxicol Sci. 2000 May;55(1):24-35 [10788556] Wien Klin Wochenschr. 2002 Mar 28;114(5-6):216-21 [12238312] J Toxicol Environ Health A. 2003 Aug 8;66(15):1441-52 [12857634] Free Radic Biol Med. 2003 Aug 15;35(4):327-40 [12899936] J Toxicol Environ Health A. 2004 Jan 9;67(1):87-107 [14668113] Toxicol Sci. 2004 Jan;77(1):126-34 [14514958] Toxicol Sci. 2004 Jan;77(1):117-25 [14514968] Int J Cancer. 2004 May 10;109(6):799-809 [15027112] Ann N Y Acad Sci. 2004 May;1013:1-16 [15194603] Mutat Res. 2004 Aug 8;562(1-2):119-31 [15279835] Philos Trans A Math Phys Eng Sci. 2004 Oct 15;362(1823):2065-98 [15370472] Cancer. 1973 May;31(5):1078-86 [4705148] Histochem J. 1979 Jul;11(4):447-55 [91593] Annu Rev Biochem. 1987;56:779-827 [3304147] Vopr Onkol. 1989;35(4):445-50 [2728386] Nature. 1990 Mar 15;344(6263):245-7 [2156165] Ann Clin Biochem. 1991 Sep;28 ( Pt 5):504-8 [1958055] Mol Carcinog. 1993;8(3):177-85 [8216736] Carcinogenesis. 1993 Nov;14(11):2419-22 [7902220] Cancer Metastasis Rev. 1994 Mar;13(1):67-89 [8143346] J Appl Physiol (1985). 1994 Sep;77(3):1060-6 [7836104] Environ Health Perspect. 1994 Oct;102 Suppl 5:173-9 [7882925] Fundam Appl Toxicol. 1995 Apr;25(1):80-94 [7541380] Inhal Toxicol. 1999 Aug;11(8):709-31 [10477444] Inhal Toxicol. 1996;8 Suppl:73-89 [11542496] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708 [15951334] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L696-7 [16214820] Toxicol Sci. 2006 Apr;90(2):400-18 [16410370] Toxicol Sci. 2006 Jul;92(1):5-22 [16484287] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1152/ajplung.90287.2008 ER - TY - JOUR T1 - Speak up about patient allergies. AN - 69593786; 18812983 JF - Nursing AU - Woo, Eileen AD - Center for Devices and Radiological Health. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 13 VL - 38 IS - 10 KW - Polyglactin 910 KW - 34346-01-5 KW - Nursing KW - United States KW - United States Food and Drug Administration KW - Humans KW - Polyglactin 910 -- adverse effects KW - Hypersensitivity -- immunology KW - Hypersensitivity -- physiopathology KW - Sutures -- adverse effects KW - Hypersensitivity -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69593786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing&rft.atitle=Speak+up+about+patient+allergies.&rft.au=Woo%2C+Eileen&rft.aulast=Woo&rft.aufirst=Eileen&rft.date=2008-10-01&rft.volume=38&rft.issue=10&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Nursing&rft.issn=1538-8689&rft_id=info:doi/10.1097%2F01.NURSE.0000337215.94183.46 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-04 N1 - Date created - 2008-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.NURSE.0000337215.94183.46 ER - TY - JOUR T1 - All hemoglobin-based oxygen carriers are not created equally. AN - 69590577; 18206989 AB - Hemoglobin (Hb)-based oxygen carriers (HBOCs) also known as "blood substitutes" have been under active clinical development over the last two decades. Cell-free Hb outside its natural protective red blood cell environment, as is the case with all HBOCs, has been shown to be vasoactive in part due to the scavenging of vascular endothelial nitric oxide (NO) and may in some instances induce heme-mediated oxidative stress. Chemical modification intended to stabilize HBOCs in the tetrameric or polymeric forms introduces conformational constraints that result in proteins with diverse allosteric responses as well as oxidative and nitrosative redox side reactions. Intra and inter-molecular cross-linking may in some instances also determine the interactions between HBOCs and normal oxidative inactivation and clearance mechanisms. Oxygen and oxidative reactions of normal and several cross-linked Hbs as well as their interactions with endogenous plasma protein (haptoglobin) and cellular receptor pathways (macrophage CD163) differ significantly. Therefore, safety and efficacy may be addressed by designing HBOCs with modifications that limit hypertension, minimize heme destabilization and take into account endogenous Hb removal mechanisms to optimize exposure times for a given indication. JF - Biochimica et biophysica acta AU - Buehler, Paul W AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology (LBVB), Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Maryland 20892, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1378 EP - 1381 VL - 1784 IS - 10 SN - 0006-3002, 0006-3002 KW - Blood Substitutes KW - 0 KW - Drug Carriers KW - HBOC 201 KW - Hemoglobins KW - Oxyhemoglobins KW - Heme KW - 42VZT0U6YR KW - Index Medicus KW - Drug Carriers -- therapeutic use KW - Hypertension -- chemically induced KW - Heme -- toxicity KW - Hypertension -- prevention & control KW - Humans KW - Drug Carriers -- chemistry KW - Hemoglobins -- therapeutic use KW - Oxyhemoglobins -- chemistry KW - Blood Substitutes -- chemistry KW - Blood Substitutes -- therapeutic use KW - Oxyhemoglobins -- toxicity KW - Oxyhemoglobins -- therapeutic use KW - Hemoglobins -- chemistry KW - Blood Substitutes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69590577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=All+hemoglobin-based+oxygen+carriers+are+not+created+equally.&rft.au=Buehler%2C+Paul+W%3BAlayash%2C+Abdu+I&rft.aulast=Buehler&rft.aufirst=Paul&rft.date=2008-10-01&rft.volume=1784&rft.issue=10&rft.spage=1378&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbapap.2007.12.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbapap.2007.12.009 ER - TY - JOUR T1 - Cytochrome c: a non-invasive biomarker of drug-induced liver injury. AN - 69583519; 18418843 AB - Limitations of existing biomarkers to detect liver injury in experimental animals highlight the need for additional tools to predict human toxicity. The utility of cytochrome c (cyt c) as a biomarker in serum and urine was evaluated in two rodent liver injury models. Adult Sprague-Dawley rats treated with acetaminophen or D-galactosamine (GalN) showed dose- and time-dependent histomorphological changes and TUNEL staining in liver consistent with hepatocellular necrosis, apoptosis and inflammation up to 72 h. Matching changes in serum alanine transaminase (ALT), aspartate transaminase (AST) and cyt c peaked at 24 h for either drug at the highest dose, cyt c falling rapidly at 48 hours with ALT and AST remained high. Intracellular transit of cyt c from mitochondria to the cytoplasm in damaged hepatocytes, and then to peripheral circulation, was observed by immunohistochemistry. Correlation coefficients between cyt c and serum diagnostic tests indicate the liver to be the primary source of cyt c. Urinary analysis for cyt c revealed time-dependent increase at 6 h, peaking at 24 h in GalN-treated rats in contrast with irregular patterns of urinary ALT and AST activity. Histological changes detected at 6 h preceded altered ALT, AST and cyt c at 12 and 18 h, respectively, in GalN-treated rats. These studies demonstrate cyt c to be a useful indicator of hepatic injury in rodents and support its utility as a non-invasive predictor of drug-induced hepatotoxicity, when utilized as a potential urinary biomarker. JF - Journal of applied toxicology : JAT AU - Miller, T J AU - Knapton, A AU - Adeyemo, O AU - Noory, L AU - Weaver, J AU - Hanig, J P AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. terry.miller@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 815 EP - 828 VL - 28 IS - 7 SN - 0260-437X, 0260-437X KW - Biomarkers KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Galactosamine KW - 7535-00-4 KW - Cytochromes c KW - 9007-43-6 KW - Index Medicus KW - Acute Disease KW - Animals KW - Hepatocytes -- drug effects KW - Dose-Response Relationship, Drug KW - Mitochondria -- enzymology KW - Disease Models, Animal KW - Hepatocytes -- pathology KW - Hepatocytes -- enzymology KW - Rats KW - Rats, Sprague-Dawley KW - Galactosamine -- toxicity KW - Necrosis -- chemically induced KW - Apoptosis -- drug effects KW - Mitochondria -- drug effects KW - Acetaminophen -- toxicity KW - Male KW - Chemical and Drug Induced Liver Injury -- etiology KW - Cytochromes c -- metabolism KW - Chemical and Drug Induced Liver Injury -- pathology KW - Biomarkers -- metabolism KW - Chemical and Drug Induced Liver Injury -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69583519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Cytochrome+c%3A+a+non-invasive+biomarker+of+drug-induced+liver+injury.&rft.au=Miller%2C+T+J%3BKnapton%2C+A%3BAdeyemo%2C+O%3BNoory%2C+L%3BWeaver%2C+J%3BHanig%2C+J+P&rft.aulast=Miller&rft.aufirst=T&rft.date=2008-10-01&rft.volume=28&rft.issue=7&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.1347 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-09-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jat.1347 ER - TY - JOUR T1 - Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. AN - 69566116; 18802068 AB - Nonalcoholic steatohepatitis (NASH), the most common cause of chronic liver fibrosis, progresses to cirrhosis in up to 20% of patients. We report that hepatic stellate cells (HSC) in sinusoidal lesions of liver of patients with NASH express high levels of high-affinity IL-13R (IL-13Ralpha2), which is colocalized with smooth muscle actin, whereas fatty liver and normal liver specimens do not express IL-13Ralpha2. HSCs engineered to overexpress IL-13Ralpha2 respond to IL-13 and induce TGFB1 promoter activity and TGF-beta1 production. We also developed NASH in rats by feeding a choline-deficient l-amino acid diet. These rats developed liver fibrosis as assessed by H&E staining, Masson's trichrome and Sirius red staining, and hydroxyproline assays. Treatment of these rats with IL-13R-directed cytotoxin caused a substantial decline in fibrosis and liver enzymes without organ toxicity. These studies demonstrate that functional IL-13Ralpha2 are overexpressed in activated HSCs involved in NASH and that IL-13 cytotoxin ameliorates pathological features of NASH in rat liver, indicating a novel role of this cytotoxin in potential therapy. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Shimamura, Takeshi AU - Fujisawa, Toshio AU - Husain, Syed R AU - Kioi, Mitomu AU - Nakajima, Atsushi AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/10/01/ PY - 2008 DA - 2008 Oct 01 SP - 4656 EP - 4665 VL - 181 IS - 7 KW - Cytotoxins KW - 0 KW - Exotoxins KW - IL13-PE38 KW - Interleukin-13 KW - Interleukin-13 Receptor alpha2 Subunit KW - RNA, Messenger KW - Receptors, Interleukin-13 KW - Recombinant Fusion Proteins KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Hepatic Stellate Cells -- pathology KW - Gene Expression Regulation -- immunology KW - Humans KW - Disease Models, Animal KW - Cell Line, Tumor KW - Interleukin-13 Receptor alpha2 Subunit -- biosynthesis KW - RNA, Messenger -- biosynthesis KW - Rats KW - Hepatic Stellate Cells -- metabolism KW - Rats, Inbred F344 KW - Interleukin-13 Receptor alpha2 Subunit -- physiology KW - Cells, Cultured KW - Interleukin-13 Receptor alpha2 Subunit -- genetics KW - Signal Transduction -- immunology KW - Hepatic Stellate Cells -- immunology KW - Male KW - Cell Line KW - Cytotoxins -- metabolism KW - Fatty Liver -- metabolism KW - Liver Cirrhosis -- therapy KW - Recombinant Fusion Proteins -- physiology KW - Fatty Liver -- immunology KW - Exotoxins -- physiology KW - Interleukin-13 -- physiology KW - Fatty Liver -- therapy KW - Interleukin-13 -- therapeutic use KW - Cytotoxins -- therapeutic use KW - Receptors, Interleukin-13 -- physiology KW - Liver Cirrhosis -- metabolism KW - Liver Cirrhosis -- immunology KW - Exotoxins -- therapeutic use KW - Recombinant Fusion Proteins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69566116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Novel+role+of+IL-13+in+fibrosis+induced+by+nonalcoholic+steatohepatitis+and+its+amelioration+by+IL-13R-directed+cytotoxin+in+a+rat+model.&rft.au=Shimamura%2C+Takeshi%3BFujisawa%2C+Toshio%3BHusain%2C+Syed+R%3BKioi%2C+Mitomu%3BNakajima%2C+Atsushi%3BPuri%2C+Raj+K&rft.aulast=Shimamura&rft.aufirst=Takeshi&rft.date=2008-10-01&rft.volume=181&rft.issue=7&rft.spage=4656&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-24 N1 - Date created - 2008-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment. AN - 69556004; 18798697 AB - The impact of an inflammatory response, as well as interactions between the immune and nervous systems, are rapidly assuming major roles in neurodegenerative disease and injury. However, it is now appreciated that the exact nature of such responses can differ with each type of insult and interaction. More recently, neuroinflammation and the associated cellular response of microglia are being considered for their contribution to neurotoxicity of environmental agents; yet, so far, the inclusion of inflammatory end points into neurotoxicity assessment have relied primarily on relatively limited measures or driven by in vitro models of neurotoxicity. To present background information on relevant biological considerations of neuroinflammation and the microglia response demonstrating the complex integrative nature of these biological processes and raising concern with regards to translation of effects demonstrated in vitro to the in vivo situation. Specific points are addressed that would influence the design and interpretation of neuroinflammation with regards to neurotoxicology assessment. There is a complex and dynamic response in the brain to regulate inflammatory processes and maintain a normal homeostatic level. The classification of such responses as beneficial or detrimental is an oversimplification. Neuroinflammation should be considered as a balanced network of processes in which subtle modifications can shift the cells toward disparate outcomes. The tendency to overinterpret data obtained in an isolated culture system should be discouraged. Rather, the use of cross-disciplinary approaches to evaluate several end points should be incorporated into the assessment of inflammatory contributions to the neurotoxicity of environmental exposures. JF - Expert opinion on drug metabolism & toxicology AU - Harry, Gaylia Jean AU - Kraft, Andrew D AD - National Institute of Environmental Health Sciences, National Institutes of Health, Neurotoxicology Group, Laboratory of Neurobiology, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. harry@niehs.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1265 EP - 1277 VL - 4 IS - 10 SN - 1742-5255, 1742-5255 KW - Inflammation Mediators KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Neurodegenerative Diseases -- metabolism KW - Cell Culture Techniques KW - Nervous System -- metabolism KW - Down-Regulation -- immunology KW - Nervous System -- pathology KW - Models, Biological KW - Inflammation Mediators -- metabolism KW - Neurotoxicity Syndromes -- diagnosis KW - Inflammation -- physiopathology KW - Neurotoxicity Syndromes -- etiology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69556004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Neuroinflammation+and+microglia%3A+considerations+and+approaches+for+neurotoxicity+assessment.&rft.au=Harry%2C+Gaylia+Jean%3BKraft%2C+Andrew+D&rft.aulast=Harry&rft.aufirst=Gaylia&rft.date=2008-10-01&rft.volume=4&rft.issue=10&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425255.4.10.1265 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci Res. 1998 Aug 1;53(3):361-7 [9698164] J Neurosci. 1998 Aug 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Immunol. 2007 Jan;28(1):12-8 [17129764] Brain Res. 2007 Feb 2;1131(1):17-28 [17161388] Nat Rev Immunol. 2007 Feb;7(2):161-7 [17220915] J Neuroimmunol. 2007 Feb;183(1-2):125-32 [17229471] J Neurosci. 2007 Mar 7;27(10):2596-605 [17344397] Brain Behav Immun. 2007 May;21(4):367-73 [17234380] Neuroreport. 2007 Mar 26;18(5):425-9 [17496797] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425255.4.10.1265 ER - TY - JOUR T1 - Use of flow cytometry in an apoptosis assay to determine pH and temperature stability of shiga-like toxin 1. AN - 69521417; 18710788 AB - Shiga toxins and Shiga-like toxins (Stx) are a relatively large group of cytotoxins produced by certain serotypes of Shigella and E. coli (STEC). These toxins are responsible for diarrhea, hemorrhagic colitis and may induce hemolytic uremic syndrome (HUS) with serious consequences in young children. The toxins are proteins made up of 5 small B subunits responsible for binding to an outer membrane ligand on host cells and surround the larger, biologically active A subunit. For Shiga-like toxin 1 (Stx1), the cellular receptor is the carbohydrate globotriose. Stx1was purified from STEC. We utilized induction of apoptosis in the human monocyte cell line THP-1, as a biological endpoint to test the stability of Stx1 activity added to fruit punch at different pH (2-9) and temperatures (4 and 20 degrees C). A flow cytometric method was used to test for early and late apoptotic events based on binding of R-phycoerytherin-labeled annexin V to exposed membrane phosphatidyl serine. Membrane permeability to 7-Amino-actinomycin corresponds with late apoptosis or necrosis. The combination of acid pH and higher storage temperature resulted in greatest degree of toxin inactivation. This approach provides a rapid and high throughput method to determine the functional activity of Stx1, and related toxins in a food matrix. JF - Journal of microbiological methods AU - Babu, Uma S AU - Gaines, Dennis M AU - Wu, Yang AU - Westphal, Carmen D AU - Pereira, Marion AU - Raybourne, Richard B AD - Immunobiology Branch, Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Rd., Laurel, MD, 20708 USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 167 EP - 171 VL - 75 IS - 2 SN - 0167-7012, 0167-7012 KW - Shiga Toxin 1 KW - 0 KW - Index Medicus KW - Hydrogen-Ion Concentration KW - Humans KW - Temperature KW - Escherichia coli O157 -- metabolism KW - Cell Line KW - Shiga Toxin 1 -- chemistry KW - Apoptosis KW - Shiga Toxin 1 -- metabolism KW - Monocytes -- drug effects KW - Shiga Toxin 1 -- toxicity KW - Flow Cytometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69521417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+microbiological+methods&rft.atitle=Use+of+flow+cytometry+in+an+apoptosis+assay+to+determine+pH+and+temperature+stability+of+shiga-like+toxin+1.&rft.au=Babu%2C+Uma+S%3BGaines%2C+Dennis+M%3BWu%2C+Yang%3BWestphal%2C+Carmen+D%3BPereira%2C+Marion%3BRaybourne%2C+Richard+B&rft.aulast=Babu&rft.aufirst=Uma&rft.date=2008-10-01&rft.volume=75&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Journal+of+microbiological+methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2008.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-24 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mimet.2008.05.014 ER - TY - BOOK T1 - Personal Protective Equipment for Health Care Workers Who Work with Hazardous Drugs AN - 58783877; 2008-218165 AB - Health care workers who handle hazardous drugs are at risk of skin rashes, cancer, and reproductive disorders. NIOSH recommends that employers provide appropriate personal protective equipment (PPE) to protect workers who handle hazardous drugs in the workplace. References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Oct 2008, 4 pp. AU - National Inst Occupational Safety and Health Y1 - 2008/10// PY - 2008 DA - October 2008 EP - 4p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Health conditions and policy - Physicians, nurses, and other health personnel KW - Environment and environmental policy - Radioactive and dangerous substances KW - Manufacturing and heavy industry - Machinery and equipment industry KW - Manufacturing and heavy industry - Pharmaceutical industry KW - Business and service sector - Business operations, practices, and workplaces KW - Social conditions and policy - Public safety and security KW - Equipment KW - Hazardous materials KW - Medical workers KW - Safety measures KW - Workplaces KW - Drugs KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58783877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Inst+Occupational+Safety+and+Health&rft.aulast=National+Inst+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2008-10-01&rft.volume=&rft.issue=&rft.spage=4p&rft.isbn=&rft.btitle=Personal+Protective+Equipment+for+Health+Care+Workers+Who+Work+with+Hazardous+Drugs&rft.title=Personal+Protective+Equipment+for+Health+Care+Workers+Who+Work+with+Hazardous+Drugs&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/wp-solutions/2009-106/default.html LA - English DB - PAIS Index N1 - Date revised - 2009-01-09 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - SuppNotes - NIOSH Publication No. 2009-106 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Physical victimization in prison: The role of mental illness AN - 57297086; 200913800 AB - This study compares prison physical victimization rates (inmate-on-inmate and staff-on-inmate) for people with mental disorder to those without mental disorder in a state prison system. Inmate subjects were drawn from 14 adult prisons operated by a single mid-Atlantic State. A sample of 7528 subjects aged 18 or older (7221 men and 564 women) completed an audio-computer administered survey instrument. Mental disorder was based on self-reported mental health treatment ever for particular mental disorders. Approximately one-quarter of the sample reported some prior treatment for schizophrenia, bipolar disorder, depression, PTSD, or anxiety disorder. Rates of physical victimization for males with any mental disorder were 1.6 times (inmate-on-inmate) and 1.2 times (staff-on-inmate) higher than that of males with no mental disorder. Female inmates with mental disorder were 1.7 times more likely to report being physically victimized by another inmate than did their counterparts with no mental disorder. Overall, both males and females with mental disorder are disproportionately represented among victims of physical violence inside prison. Adapted from the source document. JF - International Journal of Law and Psychiatry AU - Blitz, Cynthia L AU - Wolff, Nancy AU - Shi, Jing AD - Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, N.J., USA clblitz@rci.rutgers.edu Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 385 EP - 393 PB - Elsevier Ltd., The Netherlands VL - 31 IS - 5 SN - 0160-2527, 0160-2527 KW - Physical victimization Prison Mental illness KW - Prisons KW - Mental health services KW - Men KW - Psychiatric disorders KW - Prisoners KW - Victimization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57297086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Law+and+Psychiatry&rft.atitle=Physical+victimization+in+prison%3A+The+role+of+mental+illness&rft.au=Blitz%2C+Cynthia+L%3BWolff%2C+Nancy%3BShi%2C+Jing&rft.aulast=Blitz&rft.aufirst=Cynthia&rft.date=2008-10-01&rft.volume=31&rft.issue=5&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Law+and+Psychiatry&rft.issn=01602527&rft_id=info:doi/10.1016%2Fj.ijlp.2008.08.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - CODEN - IJLPDI N1 - SubjectsTermNotLitGenreText - Psychiatric disorders; Prisons; Prisoners; Victimization; Mental health services; Men DO - http://dx.doi.org/10.1016/j.ijlp.2008.08.005 ER - TY - JOUR T1 - Expanding the Role of Health Services Research as a Tool to Reduce the Public Health Burden of Alcohol Use Disorders AN - 57279731; 200903429 AB - The public and private cost of 'heavy alcohol use'1 is estimated to be more than 187 billion in lost productivity, health care and criminal justice expenditures, and other costs. This does not include the emotional and psychological costs to family, friends, and the community. Investments by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have led to a number of important advances in pharmacological and behavioral treatments for alcohol disorders. Yet, there continues to be a significant gap between research findings and progress in community-based care. Additionally, limited capacity, a lack of acknowledged standards, and a separation between the specialty substance use treatment sector and general medical practice contribute to this gap. As part of its ongoing efforts to encourage translation from clinical research to practice, NIAAA undertook a review of its alcohol related health services research program for the purpose of creating a vision for the next 10 yr that is sensitive to the changing needs of both the clinical and research communities. Central to the development of a new research agenda is a reconceptualization of alcohol use and misuse along a continuum that takes into account quantity and frequency of use as well as the consequences from 'heavy use' and misuse of alcohol. This public health approach recommends a number of high priority areas to expand and improve the system of care for 'heavy alcohol users' who may be at-risk or who may have developed an alcohol use disorder. These recommendations include research on dissemination and implementation of evidence-based practices, and improving access and utilization to care for individuals who are 'heavy users.' The paper concludes by outlining some of the steps taken by NIAAA to further the continuing development of alcohol health services research. Adapted from the source document. JF - Substance Use & Misuse AU - Delany, Peter J AU - Shields, Joseph J AU - Willenbring, Mark L AU - Huebner, Robert B AD - Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1729 EP - 1746 PB - Taylor & Francis, Philadelphia PA VL - 43 IS - 12 SN - 1082-6084, 1082-6084 KW - Alcohol consumption KW - Alcoholism KW - Heavy drinking KW - Community care KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57279731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Expanding+the+Role+of+Health+Services+Research+as+a+Tool+to+Reduce+the+Public+Health+Burden+of+Alcohol+Use+Disorders&rft.au=Delany%2C+Peter+J%3BShields%2C+Joseph+J%3BWillenbring%2C+Mark+L%3BHuebner%2C+Robert+B&rft.aulast=Delany&rft.aufirst=Peter&rft.date=2008-10-01&rft.volume=43&rft.issue=12&rft.spage=1729&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1080%2F10826080802345341 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Alcohol consumption; Alcoholism; Heavy drinking; Public health; Community care DO - http://dx.doi.org/10.1080/10826080802345341 ER - TY - JOUR T1 - Use of progression-free survival as a surrogate marker in oncology trials: some regulatory issues AN - 57257401; 200823285 AB - There has been interest in using progression-free survival as a surrogate endpoint for overall survival in oncology clinical trials. In order to objectively define this endpoint, clear understanding of what progression means, how it is measured and what its implications are need to be discussed. This article discusses some regulatory aspects of using progression-free survival as an endpoint. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Chakravarty, Aloka AU - Sridhara, Rajeshwari AD - Office of Biostatistics, Center for Drug Evaluation and Research, FDA, MD, USA aloka.chakravarty@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 515 EP - 518 PB - Hodder Arnold, London UK VL - 17 IS - 5 SN - 0962-2802, 0962-2802 KW - Statistics KW - Oncology KW - Regulation KW - Clinical trials KW - Markers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57257401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Use+of+progression-free+survival+as+a+surrogate+marker+in+oncology+trials%3A+some+regulatory+issues&rft.au=Chakravarty%2C+Aloka%3BSridhara%2C+Rajeshwari&rft.aulast=Chakravarty&rft.aufirst=Aloka&rft.date=2008-10-01&rft.volume=17&rft.issue=5&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280207081862 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-12-09 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Oncology; Regulation; Clinical trials; Statistics; Markers DO - http://dx.doi.org/10.1177/0962280207081862 ER - TY - JOUR T1 - An Analysis of Factors Underlying E-Health Disparities AN - 57257140; 200900064 AB - Discusses e-health disparities in terms of differences in Internet access, information seeking, & literacy. A user-centered approach to consumer e-health is outlined. Adapted from the source document. JF - Cambridge Quarterly of Healthcare Ethics AU - Baur, Cynthia AD - Division of Health Communication and Marketing, National Center for Health Marketing, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Washington, DC Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 417 EP - 428 PB - Cambridge University Press, New York NY VL - 17 IS - 4 SN - 0963-1801, 0963-1801 KW - Information seeking KW - Consumers KW - Literacy KW - Internet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57257140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cambridge+Quarterly+of+Healthcare+Ethics&rft.atitle=An+Analysis+of+Factors+Underlying+E-Health+Disparities&rft.au=Baur%2C+Cynthia&rft.aulast=Baur&rft.aufirst=Cynthia&rft.date=2008-10-01&rft.volume=17&rft.issue=4&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Cambridge+Quarterly+of+Healthcare+Ethics&rft.issn=09631801&rft_id=info:doi/10.1017%2FS0963180108080547 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Internet; Consumers; Literacy; Information seeking DO - http://dx.doi.org/10.1017/S0963180108080547 ER - TY - JOUR T1 - Trends in Racial Disparities Among the Elderly for Selected Procedures AN - 57252805; 200823189 AB - The authors examine trends over 1997-2001 in racial or ethnic disparities in the utilization of three costly, referral-sensitive procedures among the elderly-coronary artery bypass grafting (CABG), percutaneous transluminal coronary angioplasty (PTCA), and hip/joint replacement. Using a multivariate framework, they undertake a simultaneous examination of the relationships between patient, local area context, and health systems on these admission types after comparing them to a control group. This period spans the implementation of the Balanced Budget Act and a major Department of Health and Human Services initiative to reduce disparities in cardiovascular and other diseases. Findings suggest increasing disparities for African Americans relative to Whites in their lower utilization of CABG and PTCA over time, and increasing disparities in the utilization of hip/joint replacement among other races' relative to Whites. The authors find that racial or ethnic disparities in use of referral-sensitive procedures did not narrow over 1997-2001. [Copyright 2008 Sage Publications, Inc.] JF - Medical Care Research and Review AU - Basu, Jayasree AU - Mobley, Lee R AD - Agency for Healthcare Research and Quality, Rockville, Maryland Jayasree.basu@ahrq.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 617 EP - 637 PB - Sage Publications, Thousand Oaks CA VL - 65 IS - 5 SN - 1077-5587, 1077-5587 KW - racial disparities CABG PTCA hip/joint replacement referral-sensitive procedures elderly KW - Elderly people KW - Health inequalities KW - Referrals KW - Medical services KW - Racial inequalities KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57252805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=Trends+in+Racial+Disparities+Among+the+Elderly+for+Selected+Procedures&rft.au=Basu%2C+Jayasree%3BMobley%2C+Lee+R&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2008-10-01&rft.volume=65&rft.issue=5&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558708318284 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-12-09 N1 - Last updated - 2016-09-27 N1 - CODEN - MCRRFH N1 - SubjectsTermNotLitGenreText - Health inequalities; Racial inequalities; Elderly people; Referrals; Medical services DO - http://dx.doi.org/10.1177/1077558708318284 ER - TY - JOUR T1 - Host Biomarkers and Biological Pathways That Are Associated with the Expression of Experimental Cerebral Malaria in Mice AN - 21508659; 12495206 AB - Cerebral malaria (CM) is a primary cause of malaria-associated deaths among young African children. Yet no diagnostic tools are available that could be used to predict which of the children infected with Plasmodium falciparum malaria will progress to CM. We used the Plasmodium berghei ANKA murine model of experimental cerebral malaria (ECM) and high-density oligonucleotide microarray analyses to identify host molecules that are strongly associated with the clinical symptoms of ECM. Comparative expression analyses were performed with C57BL/6 mice, which have an ECM-susceptible phenotype, and with mice that have ECM-resistant phenotypes: CD8 knockout and perforin knockout mice on the C57BL/6 background and BALB/c mice. These analyses allowed the identification of more than 200 host molecules (a majority of which had not been identified previously) with altered expression patterns in the brain that are strongly associated with the manifestation of ECM. Among these host molecules, brain samples from mice with ECM expressed significantly higher levels of p21, metallothionein, and hemoglobin 1 proteins by Western blot analysis than mice unaffected by ECM, suggesting the possible utility of these molecules as prognostic biomarkers of CM in humans. We suggest that the higher expression of hemoglobin 1 in the brain may be associated with ECM and could be a source of excess heme, a molecule that is considered to trigger the pathogenesis of CM. Our studies greatly enhance the repertoire of host molecules for use as diagnostics and novel therapeutics in CM. JF - Infection and Immunity AU - Oakley, Miranda S AU - McCutchan, Thomas F AU - Anantharaman, Vivek AU - Ward, Jerrold M AU - Faucette, Laurence AU - Erexson, Cindy AU - Mahajan, Babita AU - Zheng, Hong AU - Majam, Victoria AU - Aravind, L AU - Kumar, Sanjai AD - Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Sanjai.kumar@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 4518 EP - 4529 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 10 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; CSA Neurosciences Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Symptoms KW - Parasites KW - Human diseases KW - Heme KW - Metallothionein KW - Animal models KW - Malaria KW - Oligonucleotides KW - Phenotypes KW - Public health KW - Hemoglobin KW - Western blotting KW - Perforin KW - Chromium KW - Brain KW - Plasmodium falciparum KW - CD8 antigen KW - Immunity KW - Children KW - biomarkers KW - Plasmodium berghei KW - Extracellular matrix KW - Africa KW - Haemoglobins KW - K 03410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21508659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Host+Biomarkers+and+Biological+Pathways+That+Are+Associated+with+the+Expression+of+Experimental+Cerebral+Malaria+in+Mice&rft.au=Oakley%2C+Miranda+S%3BMcCutchan%2C+Thomas+F%3BAnantharaman%2C+Vivek%3BWard%2C+Jerrold+M%3BFaucette%2C+Laurence%3BErexson%2C+Cindy%3BMahajan%2C+Babita%3BZheng%2C+Hong%3BMajam%2C+Victoria%3BAravind%2C+L%3BKumar%2C+Sanjai&rft.aulast=Oakley&rft.aufirst=Miranda&rft.date=2008-10-01&rft.volume=76&rft.issue=10&rft.spage=4518&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00525-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Symptoms; Human diseases; Brain; Malaria; Immunity; Phenotypes; Haemoglobins; Public health; Perforin; Western blotting; Metallothionein; Chromium; Heme; Animal models; CD8 antigen; Children; biomarkers; Oligonucleotides; Hemoglobin; Extracellular matrix; Plasmodium falciparum; Plasmodium berghei; Africa DO - http://dx.doi.org/10.1128/IAI.00525-08 ER - TY - JOUR T1 - Transformation of N-Phenylpiperazine by Mixed Cultures from a Municipal Wastewater Treatment Plant AN - 21506980; 12494840 AB - Samples from a wastewater treatment plant were used as inocula for mixed cultures dosed with N-phenylpiperazine (NPP), a model compound containing the piperazine ring found in many fluoroquinolones. Chemical analyses showed that NPP (50 mg liter-1) disappeared in 12 days, with the appearance of a transient metabolite and two nitrosated compounds. JF - Applied and Environmental Microbiology AU - Jung, Carina M AU - Heinze, Thomas M AU - Deck, Joanna AU - Strakosha, Ruth AU - Sutherland, John B AD - Divisions of Microbiology, john.sutherland@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 6147 EP - 6150 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 74 IS - 19 SN - 0099-2240, 0099-2240 KW - Aqualine Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Water Resources Abstracts KW - Chemical Analysis KW - Wastewater Facilities KW - Mixed culture KW - AQ 00006:Sewage KW - SW 3040:Wastewater treatment processes KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21506980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Transformation+of+N-Phenylpiperazine+by+Mixed+Cultures+from+a+Municipal+Wastewater+Treatment+Plant&rft.au=Jung%2C+Carina+M%3BHeinze%2C+Thomas+M%3BDeck%2C+Joanna%3BStrakosha%2C+Ruth%3BSutherland%2C+John+B&rft.aulast=Jung&rft.aufirst=Carina&rft.date=2008-10-01&rft.volume=74&rft.issue=19&rft.spage=6147&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00516-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Mixed culture; Wastewater Facilities DO - http://dx.doi.org/10.1128/AEM.00516-08 ER - TY - RPRT T1 - A Maintenance Worker Dies When He Falls Off the Roof of an Apartment Building AN - 20967516; 11069909 AB - A 42-year-old Hispanic maintenance worker died when he fell from the flat roof of a three-story apartment building. The victim was working by himself repairing a leak in the roof at the time of the incident. There were no warning lines or perimeter barriers on the roof and the victim was not using any personal fall protection equipment. The employer of the victim did not have any safety or training programs available for their employees. The CA/FACE investigator determined that, in order to prevent future occurrences, employers should: Ensure fall protection is used by workers performing roof repairs. Develop and implement a safety and training program for employees to follow. In addition: Building owners should consider the installation of guardrails around the perimeter of flat roofs wherever feasible. JF - A Maintenance Worker Dies When He Falls Off the Roof of an Apartment Building. [np]. 2008. AU - Anonymous Y1 - 2008/10// PY - 2008 DA - Oct 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Housing KW - Training KW - Protective equipment KW - Maintenance KW - Residential areas KW - Ethnic groups KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Maintenance+Worker+Dies+When+He+Falls+Off+the+Roof+of+an+Apartment+Building&rft.title=A+Maintenance+Worker+Dies+When+He+Falls+Off+the+Roof+of+an+Apartment+Building&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Many different tumor types have polyclonal tumor origin: Evidence and implications AN - 20942936; 8467740 AB - Few ideas have gained such strong acceptance in the scientific community as the monoclonal origin of tumors; the idea that tumors start with a single mutated cell (or a single clone of cells) that go on to accumulate additional mutations as a tumor develops. The certainty with which this concept is held by the scientific community reflects the length of time it has been unchallenged and the experimental difficulty in obtaining direct evidence to the contrary. Yet, recent findings regarding X chromosome inactivation patch size indicate that the X-linked marker data previously interpreted as evidence of monoclonal tumor origin is actually more consistent with polyclonal tumor origin, a situation where two or more cells or clones of cells interact to initiate a tumor. Although most tumors show homotypy for X-linked markers (as expected given the bias conferred by X chromosome inactivation patch size), the literature contains numerous examples of tumors with X-linked marker heterotypy, examples of which encompass 24 different tumor types. Chimeric models have yielded direct unequivocal demonstrations of polyclonality in rodent and human tumors. Also, mutational data are consistent with polyclonal tumor origin. Methods that analyze levels of tumor-associated oncogene and tumor suppressor gene mutations demonstrate that initiated cells are much more common in normal tissues than previously realized. Also, while tumors have higher levels of mutation than normal tissues, oncogenic mutations frequently are present as subpopulations within tumors, rather than as the pure mutant populations expected to develop from a single initiated cell. Understanding the mutational basis of tumor etiology has important practical significance for assessing cancer risk, as well as in modeling and treating cancer. Therefore, the scientific community needs to re-examine this issue and consider the implications of polyclonal origin for, perhaps, a majority of tumors, encompassing many different tumor types. reaction JF - Mutation Research-Reviews in Mutation Research AU - Parsons, B L AD - National Center for Toxicological Research, HFT-120, 3900 NCTR Road, USFDA, Jefferson, AR 72079, United States, barbara.parsons@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 232 EP - 247 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 659 IS - 3 SN - 1383-5742, 1383-5742 KW - Genetics Abstracts; Toxicology Abstracts KW - Tumor suppressor genes KW - Etiology KW - Data processing KW - Oncogenes KW - X chromosome KW - Animal models KW - X-chromosome inactivation KW - Tumors KW - Cancer KW - G 07730:Development & Cell Cycle KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20942936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Reviews+in+Mutation+Research&rft.atitle=Many+different+tumor+types+have+polyclonal+tumor+origin%3A+Evidence+and+implications&rft.au=Parsons%2C+B+L&rft.aulast=Parsons&rft.aufirst=B&rft.date=2008-10-01&rft.volume=659&rft.issue=3&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Reviews+in+Mutation+Research&rft.issn=13835742&rft_id=info:doi/10.1016%2Fj.mrrev.2008.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Etiology; Oncogenes; Data processing; X chromosome; Animal models; X-chromosome inactivation; Tumors; Cancer DO - http://dx.doi.org/10.1016/j.mrrev.2008.05.004 ER - TY - JOUR T1 - Campylobacter-Induced Interleukin-8 Secretion in Polarized Human Intestinal Epithelial Cells Requires Campylobacter-Secreted Cytolethal Distending Toxin- and Toll-Like Receptor-Mediated Activation of NF-B AN - 20942124; 8488124 AB - Campylobacter jejuni and Campylobacter coli colonize and infect the intestinal epithelium and cause acute inflammatory diarrhea. The intestinal epithelium serves as a physical barrier to, and a sensor of, bacterial infection by secreting proinflammatory cytokines. This study examined the mechanisms for Campylobacter-induced secretion of the proinflammatory chemokine interleukin-8 (IL-8) by using polarized T84 human colonic epithelial cells as a model. C. jejuni increased the secretion of both IL-8 and tumor necrosis factor alpha (TNF-a) in polarized epithelial cells. However, the increase in IL-8 secretion was independent of Campylobacter-stimulated TNF-a secretion. Polarized T84 cells secreted IL-8 predominantly to the basolateral medium independently of the inoculation direction. While there was a significant correlation between the levels of IL-8 secretion and Campylobacter invasion, all 11 strains tested increased IL-8 secretion by polarized T84 cells despite their differences in adherence, invasion, and transcytosis efficiencies. Cell-free supernatants of Campylobacter-T84-cell culture increased IL-8 secretion to levels similar to those induced by live bacterial inoculation. The ability of the supernatant to induce IL-8 secretion was reduced by flagellum and cytolethal distending toxin (CDT) gene mutants, treatment of the supernatant with protease K or heat, or treatment of T84 cells with the Toll-like receptor (TLR) inhibitor MyD88 inhibitory peptide or chloroquine. NF-B inhibitors or cdtB mutation plus MyD88 inhibitor, but not flaA cdtB double mutations, abolished the ability of the supernatant to induce IL-8 secretion. Taken together, our results demonstrate that Campylobacter-induced IL-8 secretion requires functional flagella and CDT and depends on the activation of NF-B through TLR signaling and CDT in human intestinal epithelial cells. JF - Infection and Immunity AU - Zheng, Jie AU - Meng, Jianghong AU - Zhao, Shaohua AU - Singh, Ruby AU - Song, Wenxia AD - Department of Nutrition and Food Science. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742. Center for Veterinary Medicine, Office of Research, Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 4498 EP - 4508 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 10 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Epithelial cells KW - Chemokines KW - FlaA protein KW - Cell culture KW - Infection KW - Interleukin 8 KW - Campylobacter jejuni KW - Epithelium KW - cytolethal distending toxin KW - Diarrhea KW - MyD88 protein KW - Campylobacter coli KW - Chloroquine KW - Tumor necrosis factor-a KW - Endopeptidase K KW - Inflammation KW - Heat KW - NF-B protein KW - Inoculation KW - Intestine KW - Mutation KW - Toll-like receptors KW - Flagella KW - Signal transduction KW - X 24310:Pharmaceuticals KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20942124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Campylobacter-Induced+Interleukin-8+Secretion+in+Polarized+Human+Intestinal+Epithelial+Cells+Requires+Campylobacter-Secreted+Cytolethal+Distending+Toxin-+and+Toll-Like+Receptor-Mediated+Activation+of+NF-B&rft.au=Zheng%2C+Jie%3BMeng%2C+Jianghong%3BZhao%2C+Shaohua%3BSingh%2C+Ruby%3BSong%2C+Wenxia&rft.aulast=Zheng&rft.aufirst=Jie&rft.date=2008-10-01&rft.volume=76&rft.issue=10&rft.spage=4498&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - cytolethal distending toxin; Epithelial cells; Chemokines; Diarrhea; FlaA protein; MyD88 protein; Chloroquine; Cell culture; Infection; Tumor necrosis factor-a; Endopeptidase K; Interleukin 8; Inflammation; Heat; NF-B protein; Intestine; Inoculation; Epithelium; Mutation; Toll-like receptors; Signal transduction; Flagella; Campylobacter jejuni; Campylobacter coli ER - TY - JOUR T1 - A radiation force technique for acoustic power calibration of high intensity focused ultrasound transducers AN - 20810023; 10961575 AB - It is essential to know the acoustic power radiated by transducers used in high intensity focused ultrasound (HIFU) surgery devices for both safety and effectiveness considerations. The power radiated by medical ultrasound transducers usually is measured via radiation force balance (RFB) methods. However, for the high power focused fields encountered in HIFU applications, such measurements can be difficult due to the need for short measurement times to prevent transducer damage, heating of the RFB target, and bubble formation. To address these challenges, a procedure based on pulsed measurements was formulated. High output focused ultrasound transducers were characterized in terms of an effective duty factor, which was then used to calculate the power during the pulse at high drive levels. Two absorbing target designs were used, and both gave reliable results and displayed no damage and minimal temperature rise if placed near the HIFU transducer and away from the focus. The procedure was reproducible up to the maximum power generated of approximately 230 W, representative of the HIFU range, thus allowing the radiated power to be calibrated in terms of the peak-to-peak voltage applied to the transducer. JF - Journal of the Acoustical Society of America AU - Maruvada, S AD - U.S. Food and Drug Administration, 10903 New Hampshire Ave., Bldg. WO62-2222, Silver Spring, MD 20993, USA Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 2566 VL - 124 IS - 4 SN - 0001-4966, 0001-4966 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - alpha Radiation KW - Radiation KW - Acoustics KW - Surgery KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20810023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=A+radiation+force+technique+for+acoustic+power+calibration+of+high+intensity+focused+ultrasound+transducers&rft.au=Maruvada%2C+S&rft.aulast=Maruvada&rft.aufirst=S&rft.date=2008-10-01&rft.volume=124&rft.issue=4&rft.spage=2566&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; alpha Radiation; Radiation; Acoustics; Surgery; Ultrasound ER - TY - JOUR T1 - Stability of Picrotoxin during Yogurt Manufacture and Storage AN - 20731778; 8646591 AB - Picrotoxin is a neurotoxin found in the berries of Anamirta cocculus, a plant native to Southeast Asia. Picrotoxin has potential for being used as a biological weapon since the toxin is relatively easy to isolate and purify. Limited information exists on the stability and detection of picrotoxin added to foods before or after processing. The objective of this study was to determine the stability of picrotoxin during yogurt manufacture and storage. Direct, cup-set yogurt was produced by using methods that mimic the conditions used in full-scale production of yogurt. Milk (full-fat or low-fat) was pasteurized at 85 degree C for 30 min, and then cooled to 43 degree C. Yogurt starter culture (thermophilic culture or thermophilic + probiotic culture) and picrotoxin (200 mu g-mL milk) were added. Samples of yogurt during fermentation (5 to 6 h, 43 degree C) and during 30 d refrigerated (4 to 6 degree C) storage were analyzed for pH, titratable acidity, and picrototoxin levels. Regardless of starter culture used or fat content of milk, there were no significant differences in the pH and titratable acidities of the picrotoxin-spiked yogurt and the control yogurt (no added picrotoxin) during fermentation and up to 4 wk of refrigerated storage. The color or texture of the yogurt was not affected by addition of picrotoxin. Levels of picrotoxinin and picrotin (components of picrotoxin) in yogurt, as measured by LC-MS (APCI super(+)-SIR) did not change significantly during fermentation and storage. A separate experiment determined that addition of picrotoxin to milk before pasteurization (85 degree C, 30 min) did not affect picrotoxin stability. These results indicate that picrotoxin is stable in yogurt during manufacture and storage. JF - Journal of Food Science AU - Jablonski, JE AU - Jackson, L S AD - U.S. Food and Drug Administration (FDA), Natl. Center for Food Safety & Technology (NCFST), 6502 S. Archer Rd., Summit-Argo, IL 60501, U.S.A. Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - T121 EP - T128 PB - Institute of Food Technology VL - 73 IS - 8 SN - 0022-1147, 0022-1147 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - liquid chromatography-mass spectrometry (LC-MS) KW - manufacture KW - picrotoxin KW - stability KW - yogurt KW - Fruits KW - Starter cultures KW - Milk KW - Fermentation KW - Food KW - probiotics KW - Cocculus KW - Pasteurization KW - Color KW - Yogurt KW - Cold storage KW - Neurotoxins KW - Acidity KW - pH effects KW - J 02330:Biochemistry KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20731778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Stability+of+Picrotoxin+during+Yogurt+Manufacture+and+Storage&rft.au=Jablonski%2C+JE%3BJackson%2C+L+S&rft.aulast=Jablonski&rft.aufirst=JE&rft.date=2008-10-01&rft.volume=73&rft.issue=8&rft.spage=T121&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2Fj.1750-3841.2008.00911.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Starter cultures; Fruits; Milk; Fermentation; Food; probiotics; Pasteurization; Color; Yogurt; Cold storage; picrotoxin; Acidity; Neurotoxins; pH effects; Cocculus DO - http://dx.doi.org/10.1111/j.1750-3841.2008.00911.x ER - TY - JOUR T1 - Does increased urination frequency protect against bladder cancer? AN - 20625844; 9355814 AB - Experimental studies suggest that increased urination frequency may reduce bladder cancer risk if carcinogens are present in the urine. Only 2 small studies of the effect of increased urination frequency on bladder cancer risk in humans have been conducted with conflicting results. Our purpose was to evaluate the effect of urination frequency on risk of bladder cancer in a large, multicenter case-control study. We analyzed data based on interviews conducted with 884 patients with newly diagnosed, bladder cancer and 996 controls from 1998 to 2001 in Spain. We observed a consistent, inverse trend in risk with increasing nighttime voiding frequency in both men (p = 0.0003) and women (p = 0.07); voiding at least 2 times per night was associated with a significant, 40-50% risk reduction. The protective effect of nocturia was apparent among study participants with low, moderate and high water consumption. The risk associated with cigarette smoking was reduced by nocturia. Compared with nonsmokers who did not urinate at night, current smokers who did not urinate at night had an OR of 7.0 (95% CI = 4.7-10.2), whereas those who voided at least twice per night had an OR of 3.3 (95% CI = 1.9-5.8) (p value for trend = 0.0005). Our findings suggest a strong protective effect of nocturia on bladder cancer risk, providing evidence in humans that bladder cancer risk is related to the contact time of the urothelium with carcinogens in urine. Increased urination frequency, coupled with possible dilution of the urine from increased water intake, may diminish the effect of urinary carcinogens on bladder cancer risk. JF - International Journal of Cancer AU - Silverman, Debra T AU - Alguacil, Juan AU - Rothman, Nathaniel AU - Real, Francisco X AU - Garcia-Closas, Montserrat AU - Cantor, Kenneth P AU - Malats, Nuria AU - Tardon, Adonina AU - Serra, Consol AU - Garcia-Closas, Reina AU - Carrato, Alfredo AU - Lloreta, Josep AU - Samanic, Claudine AU - Dosemeci, Mustafa AU - Kogevinas, Manolis AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, silvermd@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1644 EP - 1648 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 7 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - water use KW - urinary bladder KW - risk reduction KW - Urine KW - Spain KW - Cigarette smoking KW - Carcinogens KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20625844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Does+increased+urination+frequency+protect+against+bladder+cancer%3F&rft.au=Silverman%2C+Debra+T%3BAlguacil%2C+Juan%3BRothman%2C+Nathaniel%3BReal%2C+Francisco+X%3BGarcia-Closas%2C+Montserrat%3BCantor%2C+Kenneth+P%3BMalats%2C+Nuria%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BGarcia-Closas%2C+Reina%3BCarrato%2C+Alfredo%3BLloreta%2C+Josep%3BSamanic%2C+Claudine%3BDosemeci%2C+Mustafa%3BKogevinas%2C+Manolis&rft.aulast=Silverman&rft.aufirst=Debra&rft.date=2008-10-01&rft.volume=123&rft.issue=7&rft.spage=1644&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23572 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - water use; risk reduction; urinary bladder; Urine; Cigarette smoking; Carcinogens; Cancer; Spain DO - http://dx.doi.org/10.1002/ijc.23572 ER - TY - JOUR T1 - Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy AN - 20466398; 9146572 AB - SummaryBackground:Topiramate was approved for the treatment of epilepsy in 1999 and has since been approved for the prevention of migraine headache. It is structurally different from the majority of antiepileptic medications and is pharmacodynamically unique in its ability to inhibit the enzyme carbonic anhydrase. Postmarketing reports of topiramate-associated hypothermia have occurred but this adverse event has not been well characterized. Data mining of an adverse event database was used to assist in the identification of hypothermia.Objective:We sought to explore a possible association between the concomitant use of topiramate and valproic acid and the induction of hypothermia.Methods:This was a pharmacovigilance case series survey of spontaneous hypothermia, a reported adverse event in patients treated with topiramate and valproic acid, alone and in combination. The U.S. Food and Drug Administration's Adverse Events Reporting System (AERS) database was searched for reports of hypothermia in association with the use of topiramate. A data mining algorithm was used on the AERS to identify scores for hypothermia associated with antiepileptic drugs.Results:We identified 22 unduplicated reports of hypothermia in patients exposed to topiramate. Three of the 22 were confounded by patient overdoses with multiple drugs and not considered. Use of more than one antiepileptic drug was reported in most of the remaining 19 reports. Of these 19 reports, valproic acid was mentioned in 7. Two of the 19 reports mentioned topiramate only. Eleven of the 19 patients were men. The median age of the 19 patients was 40years (range, 3[frac12] - 82years). Body temperatures ranged from 29.5 degree C (moderate hypothermia) to 35 degree C (mild hypothermia) with a median of 34 degree C. Eleven of 18 reports of hypothermia occurred during the cooler months (one report did not indicate the time of year in which hyopthermia occurred). Comorbid conditions included hypothyroidism in six reports, five in patients who received valproic acid concomitantly with topiramate and five reports of hyperammonemia in similarly treated patients. Data mining scores (empirical Bayes geometric mean) for antiepileptic drugs ranged from a high of 5.845 for phenobarbital to 2.956 for gabapentin. Hypothermia was reported 4.7 times more frequently when topiramate was used than was statistically expected.Conclusion:We have found hypothermia, defined as an unintentional drop in body core temperature to <35 degree C, to be associated with concomitant administration of topiramate (a carbonic anhydrase inhibitor) and valproic acid in patients who have tolerated either drug alone. Data mining analysis for topiramate showed a signal of hypothermia. Topiramate was reported 4.72 times more frequently in the database than would be statistically expected when considering all other drugs. Topiramate may act pharmacodynamically to potentiate the effects of valproic acid as a result of its ability to decrease blood HCO3- and increase blood ammonia levels. JF - Journal of Clinical Pharmacy and Therapeutics AU - Knudsen, J F AU - Sokol, G H AU - Flowers, C M AD - *New Hope Cancer Center, Hudson, FL, USA, james.knudsen@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 513 EP - 519 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 33 IS - 5 SN - 0269-4727, 0269-4727 KW - Health & Safety Science Abstracts; Risk Abstracts KW - ammonia KW - bicarbonate KW - GABAA receptor KW - hypothermia KW - topiramate KW - valproic acid KW - USA KW - Age KW - Ammonia KW - Temperature KW - prevention KW - overdose KW - Enzymes KW - Drugs KW - Side effects KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20466398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacy+and+Therapeutics&rft.atitle=Adjunctive+topiramate+enhances+the+risk+of+hypothermia+associated+with+valproic+acid+therapy&rft.au=Knudsen%2C+J+F%3BSokol%2C+G+H%3BFlowers%2C+C+M&rft.aulast=Knudsen&rft.aufirst=J&rft.date=2008-10-01&rft.volume=33&rft.issue=5&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacy+and+Therapeutics&rft.issn=02694727&rft_id=info:doi/10.1111%2Fj.1365-2710.2008.00943.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Ammonia; prevention; Temperature; Enzymes; overdose; Drugs; Side effects; USA DO - http://dx.doi.org/10.1111/j.1365-2710.2008.00943.x ER - TY - JOUR T1 - Surface chemistry reactions of alpha -terpineol [(R)-2-(4-methyl-3-cyclohexenyl)isopropanol] with ozone and air on a glass and a vinyl tile AN - 20442437; 9132180 AB - AbstractThe surface-phase reaction products of alpha -terpineol [(R)-2-(4-methyl-3-cyclohexenyl)isopropanol] with ozone (O3), air or nitrogen (N2) on both a glass and vinyl flooring tile were investigated using the recently published FLEC Automation and Control System (FACS). The FACS was used to deliver O3 (100ppb), air or N2 to the surface at a specified flow rate (300ml/min) and relative humidity (50%) after application of a 1.6% alpha -terpineol solution in methanol. Oxidation products were detected using the derivatization agents: O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine and N,O-bis(trimethysilyl)trifluoroacetamide. The positively identified reaction products were glyoxal, methylglyoxal and 4-oxopentanal. The proposed oxidation products based on previously published VOC/O3 reaction mechanisms were: 4-methylcyclohex-3-en-1-one, 6-hydroxyhept-en-2-one, 3-(1-hydroxy-1-methylethyl)-6-methylcyclohex-2-en-1-one) and one surface-enhanced reaction product: 5-(1-hydroxy-1-methylethyl)-2-methylcyclohex-2-en-1-one. Though similar products were observed in gas-phase alpha -terpineol/O3 reactions, the ratio of the reaction products were different suggesting stabilization of larger molecular weight species by the surface. Emission profiles of these oxidation products over 72h are also reported. Practical ImplicationsVolatile organic compounds (VOCs) can interact with indoor initiators [such as hydroxyl radicals (OH times ), ozone and nitrate radicals (NO3 times )] to form a number of oxygenated by-products in the gas-phase. However, when VOCs are applied to or are present on the surface, heterogeneous chemistry with indoor initiators can also occur. The surface can influence the reaction mechanism to produce new surface reaction products. The work, described here, shows the interaction of alpha -terpineol (major component of pine oil) with ozone and air on both glass and vinyl flooring. These results demonstrated emissions of oxygenated organic compounds as a result of reaction and that further investigations of this chemistry are required to accurately estimate indoor occupant exposures. JF - Indoor Air AU - Ham, JE AU - Wells, J R AD - Exposure Assessment Branch, Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, WV, USA, bvo2@cdc.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 394 EP - 407 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 18 IS - 5 SN - 0905-6947, 0905-6947 KW - Pollution Abstracts KW - alpha -Terpineol KW - Ozone KW - Reaction products KW - Surface chemistry KW - Nitrates KW - surface chemistry KW - Byproducts KW - Humidity KW - Automation KW - hydroxylamines KW - Flow rates KW - Hydroxyl radicals KW - Oil KW - Control systems KW - Atmospheric chemistry KW - Oxidation KW - Emissions KW - Indoor environments KW - Volatile organic compounds KW - Nitrogen KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20442437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+Air&rft.atitle=Surface+chemistry+reactions+of+alpha+-terpineol+%5B%28R%29-2-%284-methyl-3-cyclohexenyl%29isopropanol%5D+with+ozone+and+air+on+a+glass+and+a+vinyl+tile&rft.au=Ham%2C+JE%3BWells%2C+J+R&rft.aulast=Ham&rft.aufirst=JE&rft.date=2008-10-01&rft.volume=18&rft.issue=5&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Indoor+Air&rft.issn=09056947&rft_id=info:doi/10.1111%2Fj.1600-0668.2008.00540.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nitrates; surface chemistry; Byproducts; Automation; Humidity; hydroxylamines; Flow rates; Hydroxyl radicals; Oil; Control systems; Oxidation; Atmospheric chemistry; Emissions; Indoor environments; Volatile organic compounds; Ozone; Nitrogen DO - http://dx.doi.org/10.1111/j.1600-0668.2008.00540.x ER - TY - JOUR T1 - Tools for evidence-based toxicology: computational-based strategies as a viable modality for decision support in chemical safety evaluation and risk assessment AN - 20320363; 8933921 JF - Human & Experimental Toxicology AU - Valerio, LG Jr AD - Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave, White Oak 51, Room 4218, Silver Spring, Maryland 20993-0002, USA, Luis.Valerio@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 757 EP - 760 VL - 27 IS - 10 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - Risk assessment KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20320363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Tools+for+evidence-based+toxicology%3A+computational-based+strategies+as+a+viable+modality+for+decision+support+in+chemical+safety+evaluation+and+risk+assessment&rft.au=Valerio%2C+LG+Jr&rft.aulast=Valerio&rft.aufirst=LG&rft.date=2008-10-01&rft.volume=27&rft.issue=10&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/10.1177%2F0960327108097689 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment DO - http://dx.doi.org/10.1177/0960327108097689 ER - TY - JOUR T1 - Production of biologically active CXC chemokines by Lactococcus lactis: Evaluation of its potential as a novel mucosal vaccine adjuvant AN - 20120739; 8618180 AB - Chemokines have been described as essential mediators in leukocytes migration to inflammatory sites and to secondary lymphoid organs. Mig and IP- 10 are two CXC chemokines that recruit mononuclear cells in vivo and inhibit angiogenesis. In addition to their chemotactic roles, Mig and IP-10 have also an important role in the adaptative immune response. In this study, we asked whether a food-grade bacterium, Lactococcus lactis, is able to produce a fusion protein comprising Mig and IP-10 (Mig::IP-10). The activity of the recombinant Mig::IP-10 produced by the genetically engineered L. lactis (LL-Mig::IP-10) was confirmed in a murine spleen cells chemotaxis assay. Moreover, the adjuvant properties of LL-Mig::IP-10 strain were evaluated in mice by the co-expression of a model antigen, the human papillomavirus type 16 E7 protein. Our data show that LL-Mig::IP-10 can produce a genetic fusion of Mig::IP-10 biologically active. This recombinant strain represents a potential candidate for the development of new strategies for mucosal vaccination. JF - Vaccine AU - Cortes-Perez, Naima G AU - Medina, Luis Fda Costa AU - Lefevre, Francois AU - Langella, Philippe AU - Bermudez-Humaran, Luis G AD - INRA 0910, 78352 Jouy-en-Josas, France, luis.bermudez@jouy.inra.fr Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 5778 EP - 5783 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 46 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Chemokines KW - Adjuvant KW - Lactococcus lactis KW - Mig KW - IP-10 KW - Mucosal vaccines KW - HPV-16 KW - E7 KW - Leukocytes (mononuclear) KW - Data processing KW - CXC chemokines KW - Food KW - Mucosa KW - Angiogenesis KW - Animal models KW - Spleen KW - Adjuvants KW - Chemotaxis KW - Vaccination KW - Inflammation KW - Leukocyte migration KW - IP-10 protein KW - Human papillomavirus 16 KW - Genetic engineering KW - E7 protein KW - Vaccines KW - Immune response KW - Fusion protein KW - V 22350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20120739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Production+of+biologically+active+CXC+chemokines+by+Lactococcus+lactis%3A+Evaluation+of+its+potential+as+a+novel+mucosal+vaccine+adjuvant&rft.au=Cortes-Perez%2C+Naima+G%3BMedina%2C+Luis+Fda+Costa%3BLefevre%2C+Francois%3BLangella%2C+Philippe%3BBermudez-Humaran%2C+Luis+G&rft.aulast=Cortes-Perez&rft.aufirst=Naima&rft.date=2008-10-01&rft.volume=26&rft.issue=46&rft.spage=5778&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.08.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Leukocytes (mononuclear); Data processing; CXC chemokines; Food; Mucosa; Animal models; Angiogenesis; Spleen; Adjuvants; Vaccination; Chemotaxis; Inflammation; Leukocyte migration; IP-10 protein; Genetic engineering; E7 protein; Fusion protein; Immune response; Vaccines; Lactococcus lactis; Human papillomavirus 16 DO - http://dx.doi.org/10.1016/j.vaccine.2008.08.044 ER - TY - JOUR T1 - Defining 'Neuroinflammation' AN - 19761861; 8647702 AB - Neuroinflammation is a hot topic in contemporary neuroscience. A relatively new open-access journal, the Journal of Neuroinflammation, focuses on this field. As another example, abstracts to the 2007 Annual Meeting of the Society for Neuroscience could be submitted in several subcategories of neuroinflammation, a strong signal of growth in this research area. While it is becoming clear that activation of microglia and astroglia and the attendant expression of proinflammatory cytokines and chemokines often are associated with disease-, trauma-, and toxicant-induced damage to the CNS, it is by no means clear that a cause-and-effect relationship exists between the presence of a neuroinflammatory process and neural damage. We have explored this issue with two models of dopaminergic neurotoxicity. We used a single low-dose regimen of MPTP or METH, a paradigm that causes selective degeneration of striatal dopaminergic nerve terminals without affecting the cell body in the substantia nigra. Both compounds increased the expression of the microglia-associated factors, Il-1 alpha , Il6, Ccl2, and Tnf- alpha , and also elicited morphologic evidence of microglial activation prior to induction of astrogliosis. Pharmacologic antagonism of MPTP and METH neurotoxicity prevented these proinflammatory responses, findings suggestive of a link between neuroinflammation and the observed neurotoxic outcomes. Nevertheless, when we used minocycline to suppress the expression of all these mediators, with the exception of Tnf- alpha , we failed to see neuroprotection. Likewise, when we examined the effects of MPTP or METH in transgenic mice lacking Il6, Ccl2, or Tnfr1-2 genes, deficiency of either Il6 or Ccl2 did not alter neurotoxicity, whereas deficiency in Tnfr1-2 was neuroprotective. Although these observations pointed to a role of the proinflammatory cytokine, TNF- alpha , in the neurotoxic effects of MPTP and METH, other observations did not support this supposition. For example, activation of NF- Kappa B or induction of iNOS, known components of inflammatory responses and free radical formation, were not observed. Moreover, immunosuppressive regimens of glucocorticoids failed to suppress TNF- alpha or attenuate neurotoxicity. Taken together, our observations suggest that MPTP and METH neurotoxicity are associated with the elaboration of a 'neuroinflammatory' response, yet this response lacks key features of inflammation and, with the exception of TNF- alpha , neurotoxicity appears to be the cause rather than the consequence of proinflammatory signals. JF - Annals of the New York Academy of Sciences AU - O'Callaghan, James P AU - Sriram, Krishnan AU - Miller, Diane B AD - Centers for Disease Control and Prevention-NIOSH Morgantown, West Virginia, USA, jdo5@cdc.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 318 EP - 330 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1139 IS - 1 SN - 0077-8923, 0077-8923 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - neuroinflammation KW - neurotoxicity KW - methamphetamine KW - MPTP KW - gliosis KW - microglia KW - astroglia KW - cytokines KW - chemokines KW - dopamine KW - dopaminergic KW - Interleukin 6 KW - Central nervous system KW - Minocycline KW - Chemokines KW - Astrocytes KW - Interleukin 1 KW - Animal models KW - Neuroprotection KW - Immunosuppressive agents KW - Neurodegeneration KW - NF- Kappa B protein KW - Nerve endings KW - Dopamine KW - Neostriatum KW - Cytokines KW - Substantia nigra KW - Monocyte chemoattractant protein 1 KW - Free radicals KW - Antagonism KW - Transgenic mice KW - Microglia KW - Glucocorticoids KW - Inflammation KW - Nitric-oxide synthase KW - Neurotoxicity KW - Cell body KW - Gliosis KW - Tumor necrosis factor- alpha KW - W 30910:Imaging KW - F 06910:Microorganisms & Parasites KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19761861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Defining+%27Neuroinflammation%27&rft.au=O%27Callaghan%2C+James+P%3BSriram%2C+Krishnan%3BMiller%2C+Diane+B&rft.aulast=O%27Callaghan&rft.aufirst=James&rft.date=2008-10-01&rft.volume=1139&rft.issue=1&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1432.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Central nervous system; Chemokines; Minocycline; Astrocytes; Interleukin 1; Animal models; Neuroprotection; Neurodegeneration; Immunosuppressive agents; NF- Kappa B protein; Dopamine; Nerve endings; Neostriatum; Cytokines; Substantia nigra; Monocyte chemoattractant protein 1; MPTP; Free radicals; Antagonism; Microglia; Transgenic mice; Glucocorticoids; Inflammation; Nitric-oxide synthase; Cell body; Neurotoxicity; Gliosis; Tumor necrosis factor- alpha DO - http://dx.doi.org/10.1196/annals.1432.032 ER - TY - JOUR T1 - Using mass media campaigns to promote voluntary counseling and HIV-testing services in Kenya AN - 19748945; 8612997 AB - Background: Kenya, a country with high HIV prevalence, has seen a rapid scale-up of voluntary counseling and HIV-testing (VCT) services from three sites in 2000 to 585 by June 2005. From 2002 onwards, services were promoted by a four-phase professionally designed mass media campaign. Objective: To assess the impact of a mass media campaign on VCT services. Design: Observational data from client records. Methods: VCT client data from 131 voluntary counseling and testing sites were included. Descriptive statistics and Poisson regression were used to assess the impact of campaign phases. Results: Client records (381 160) from 131 sites were analyzed. A linear increase in new sites and an exponential increase in client utilization were observed. Regression analysis revealed that the first phase of the campaign increased attendance by 28.5% (95% confidence interval = 15.9, 42.5%) and the fourth by 42.5% (95% confidence interval = 28.4, 64.1%). These two phases, which directly mentioned HIV, had more impact on utilization than the second and third phases, which did not have a significant effect. Conclusion: The Kenyan experience suggests that a professional, intensive mass media campaign is likely to contribute to increases in utilization of testing. Expansion of programs for counseling and HIV testing in developing countries is likely to be facilitated by mass media promotion of these services. JF - AIDS AU - Marum, E AU - Morgan, G AU - Hightower, A AU - Ngare, C AU - Taegtmeyer, M AD - US Department of Health and Human Services/Centers for Disease Control and Prevention, National Center for HIV, STD, and TB Prevention, 1600 Clifton Road MS E-04, Atlanta, GA 30333, USA, emarum@cdc.gov Y1 - 2008/10/01/ PY - 2008 DA - 2008 Oct 01 SP - 2019 EP - 2024 VL - 22 IS - 15 SN - 0269-9370, 0269-9370 KW - Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - Acquired immune deficiency syndrome KW - Kenya KW - Data processing KW - Human immunodeficiency virus KW - mass media KW - Regression analysis KW - Statistical analysis KW - Developing countries KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19748945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Using+mass+media+campaigns+to+promote+voluntary+counseling+and+HIV-testing+services+in+Kenya&rft.au=Marum%2C+E%3BMorgan%2C+G%3BHightower%2C+A%3BNgare%2C+C%3BTaegtmeyer%2C+M&rft.aulast=Marum&rft.aufirst=E&rft.date=2008-10-01&rft.volume=22&rft.issue=15&rft.spage=2019&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e3283104066 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Statistical analysis; Regression analysis; Developing countries; Acquired immune deficiency syndrome; mass media; Human immunodeficiency virus; Kenya DO - http://dx.doi.org/10.1097/QAD.0b013e3283104066 ER - TY - JOUR T1 - Expectations Training for Miners Using Self-Contained Self-Rescuers in Escapes from Underground Coal Mines AN - 19602515; 8502108 AB - National Institute for Occupational Safety and Health researchers conducted a study to investigate the human response issues related to wearing a self-contained self-rescuer (SCSR). The goal was to develop training to educate miners on what they could expect from their units during an escape. Subjects included miners who had experience wearing SCSRs, manufacturers, and researchers. Results identified nine key areas of concern: (1) starting the unit, (2) unit heat, (3) induction of coughing, (4) unit taste, (5) difficulty in breathing while wearing the unit, (6) quality of the air supplied, (7) nose clips, (8) goggles, and (9) the behavior of the breathing bag. In addition, researchers reviewed the literature on human response under duress. This article describes the expectations training program, which comprises the findings of the SCSR study and what is known about the normal human response in an emergency. The authors present background on SCSRs and the SCSR switchover procedure mandated in the recent federal Mine Improvement and New Emergency Response Act of 2006, which provided the impetus for the expectations training. JF - Journal of Occupational and Environmental Hygiene AU - Kowalski-Trakofler, Kathleen M AU - Vaught, Charles AU - Brnich Jr, Michael J AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 671 EP - 677 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 10 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts KW - Training KW - Emergency preparedness KW - Reviews KW - Occupational safety KW - Coal KW - Mines KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Expectations+Training+for+Miners+Using+Self-Contained+Self-Rescuers+in+Escapes+from+Underground+Coal+Mines&rft.au=Kowalski-Trakofler%2C+Kathleen+M%3BVaught%2C+Charles%3BBrnich+Jr%2C+Michael+J&rft.aulast=Kowalski-Trakofler&rft.aufirst=Kathleen&rft.date=2008-10-01&rft.volume=5&rft.issue=10&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802333632 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Training; Reviews; Emergency preparedness; Occupational safety; Coal; Mines DO - http://dx.doi.org/10.1080/15459620802333632 ER - TY - JOUR T1 - Correlation Between Respirator Fit and Respirator Fit Test Panel Cells by Respirator Size AN - 19602410; 8502102 AB - The National Institute for Occupational Safety and Health (NIOSH), recognizing the difficulties inherent in using old military data to define modern industrial respirator fit test panels, recently completed a study to develop an anthropometric database of the measurements of heads and faces of civilian respirator users. Based on the data collected, NIOSH researchers developed two new panels for fit testing half-facepiece and full-facepiece respirators. One of the new panels (NIOSH bivariate panel) uses face length and face width. The other panel is based on principal component analysis (PCA) to identify the linear combination of facial dimensions that best explains facial variations. The objective of this study was to investigate the correlation between respirator fit and the new NIOSH respirator fit test panel cells for various respirator sizes. This study was carried out on 30 subjects that were selected in part using the new NIOSH bivariate panel. Fit tests were conducted on the test subjects using a PORTACOUNT device and three exercises. Each subject was tested with three replications of four models of P-100 half-facepiece respirators in three sizes. This study found that respirator size significantly influenced fit within a given panel cell. Face size categories also matched the respirator sizing reasonably well, in that the small, medium, and large face size categories achieved the highest geometric mean fit factors in the small, medium, and large respirator sizes, respectively. The same pattern holds for fit test passing rate. Therefore, a correlation was found between respirator fit and the new NIOSH bivariate fit test panel cells for various respirator sizes. Face sizes classified by the PCA panel also followed a similar pattern with respirator fit although not quite as consistently. For the LANL panel, however, both small and medium faces achieved best fit in small size respirators, and large faces achieved best fit in medium respirators. These findings support the selection of the facial dimensions for developing the new NIOSH bivariate respirator fit test panel. JF - Journal of Occupational and Environmental Hygiene AU - Zhuang, Ziqing AU - Groce, Dennis AU - Ahlers, Heinz W AU - Iskander, Wafik AU - Landsittel, Douglas AU - Guffey, Steve AU - Benson, Stacey AU - Viscusi, Dennis AU - Shaffer, Ronald E AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 617 EP - 628 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 10 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - principal components analysis KW - Principal components analysis KW - Occupational safety KW - Respirators KW - Military KW - Protective equipment KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Correlation+Between+Respirator+Fit+and+Respirator+Fit+Test+Panel+Cells+by+Respirator+Size&rft.au=Zhuang%2C+Ziqing%3BGroce%2C+Dennis%3BAhlers%2C+Heinz+W%3BIskander%2C+Wafik%3BLandsittel%2C+Douglas%3BGuffey%2C+Steve%3BBenson%2C+Stacey%3BViscusi%2C+Dennis%3BShaffer%2C+Ronald+E&rft.aulast=Zhuang&rft.aufirst=Ziqing&rft.date=2008-10-01&rft.volume=5&rft.issue=10&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802293810 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - principal components analysis; Principal components analysis; Occupational safety; Military; Respirators; Protective equipment DO - http://dx.doi.org/10.1080/15459620802293810 ER - TY - JOUR T1 - Effects of dietary vitamin E, C and soybean oil supplementation on antioxidant enzyme activities in liver and muscles of rats AN - 19582491; 8565421 AB - The effect of elevated levels of dietary vitamin E, C and a combination of vitamin E and C (E&C) with soybean oil on activities of antioxidant (AOE) enzymes important in the protection against lipid peroxidation was studied in male rats fed with vitamin C (12mg/g), vitamin E (3.68mg/g) or E&C (3.68mg/kg+12mg/g) supplemented diets for 28 days. Catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activity in liver, pectoralis major (PM) and sartorius (S) muscles was increased significantly in rats fed with dietary vitamin C, E separately, and vitamin C&E combination, except, superoxide dismutase (SOD), which showed no alterations. These results clearly indicated that vitamin E&C separately and E&C together increased AOE activity in liver, PM and S muscle of rats. However, vitamin E and C combination enhanced AOE activity more significantly and our findings suggest the possible role of vitamin C&E and their combination in reducing the risk of chronic diseases related to oxidative stress. JF - Food and Chemical Toxicology AU - Shireen, K F AU - Pace, R D AU - Mahboob, M AU - Khan, A T AD - Tuskegee University, Tuskegee, Alabama, USA, Kshireen@cfsan.fda.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 3290 EP - 3294 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 10 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Diets KW - glutathione reductase KW - Antioxidants KW - Muscles KW - Enzymes KW - Catalase KW - Lipid peroxidation KW - Ascorbic acid KW - Soybeans KW - Oil KW - Vitamin E KW - Glutathione peroxidase KW - Superoxide dismutase KW - Oxidative stress KW - Dietary supplements KW - Liver KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19582491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+dietary+vitamin+E%2C+C+and+soybean+oil+supplementation+on+antioxidant+enzyme+activities+in+liver+and+muscles+of+rats&rft.au=Shireen%2C+K+F%3BPace%2C+R+D%3BMahboob%2C+M%3BKhan%2C+A+T&rft.aulast=Shireen&rft.aufirst=K&rft.date=2008-10-01&rft.volume=46&rft.issue=10&rft.spage=3290&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2008.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - glutathione reductase; Diets; Antioxidants; Muscles; Enzymes; Lipid peroxidation; Catalase; Soybeans; Ascorbic acid; Oil; Vitamin E; Oxidative stress; Superoxide dismutase; Glutathione peroxidase; Dietary supplements; Liver DO - http://dx.doi.org/10.1016/j.fct.2008.07.015 ER - TY - JOUR T1 - Jarring/jolting exposure and musculoskeletal symptoms among farm equipment operators AN - 19581967; 8549520 AB - Vehicle vibration exposure has been linked to chronic back pain and low-back symptoms among agricultural tractor drivers. The objectives of this study by the National Institute for Occupational Safety and Health (NIOSH) were to assess driver whole-body vibration (WBV) exposures and recommend interventions to reduce the risk of back-related injuries, particularly relative to vehicle jarring/jolting (the transient mechanical shock components of WBV). The methodology included collecting, from two independent samples, field data and health and work history data of farm equipment operators. Data were collected during mowing, raking, baling, chiseling, tilling, and road travel for different model tractors. Spraying using a sprayer and shrub removal with a skid-steer loader were also included. Based on ISO 2631 (1985), the American Conference of Governmental Industrial Hygienists, threshold limit values, presents 0.5 m/s2 as the action level recommended by the Commission of European Communities for overall weighted total RMS acceleration (vector sum for axes x, y, and z) [ACGIH, 2006. Threshold limit values and biological exposure indices. Cincinnati, OH]. WBV measured at the operator/seat interface exceeded this action level. The roughest rides and highest vector sum accelerations occurred with small utility tractor mowers (3.3 and 2.8 m/s2) and a skid-steer loader (1.7 m/s2). Major findings from health and work history data showed 96% of participants reported having to bend or twist their necks, although 24% reported neck symptoms. Sixty-four percent of participating operators reported experiencing back symptoms (e.g., pain, aching, stiffness, etc.). Recommendations included: specifying a seat that 'better' isolates operators from jars/jolts with new tractor purchases; maintaining the seat/seat suspension and replacing worn or damaged cushions with NIOSH tested viscoelastic foam padding; using larger diameter tires with radial-ply instead of bias-ply construction, particularly on small utility tractor-mowers, to aid in attenuating ride 'roughness'; using a swivel seat to reduce the stress on the neck from bending or twisting; and improving efforts to educate owner/operators of the adverse effects of WBV exposures. Since the data presented in this paper were collected from two independent samples, the authors were unable to draw any correlations or etiological inferences from the study. However, results were compared and contrasted with other studies which included similar vibration measurements in agriculture. Relevance to industry Studies concerning agricultural tractor drivers have shown that vibration exposure and duration of exposure are associated with lifetime, transient, and chronic back pain and low-back symptoms. The results from the field measurements and health and work history data are useful for the U.S. agricultural industry to help reduce back injury risk for farm equipment operators. JF - International Journal of Industrial Ergonomics AU - Mayton, A G AU - Kittusamy, N K AU - Ambrose, D H AU - Jobes, C C AU - Legault, M L AD - NIOSH, Pittsburgh, PA, USA, amayton@cdc.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 758 EP - 766 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 38 IS - 9-10 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Injuries KW - risk reduction KW - USA, Ohio, Cincinnati KW - agriculture KW - Stress KW - back pain KW - Tires KW - Occupational safety KW - Threshold limits KW - intervention KW - farms KW - Occupational exposure KW - Ergonomics KW - Vibration KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19581967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Jarring%2Fjolting+exposure+and+musculoskeletal+symptoms+among+farm+equipment+operators&rft.au=Mayton%2C+A+G%3BKittusamy%2C+N+K%3BAmbrose%2C+D+H%3BJobes%2C+C+C%3BLegault%2C+M+L&rft.aulast=Mayton&rft.aufirst=A&rft.date=2008-10-01&rft.volume=38&rft.issue=9-10&rft.spage=758&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2007.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Ohio, Cincinnati; Vibration; Ergonomics; Occupational exposure; farms; Historical account; Threshold limits; Injuries; back pain; Stress; Occupational safety; risk reduction; agriculture; Tires; intervention DO - http://dx.doi.org/10.1016/j.ergon.2007.10.011 ER - TY - JOUR T1 - Differential Sorting of Human Parathyroid Hormone After Transduction of Mouse and Rat Salivary Glands AN - 19410054; 8759280 AB - Gene transfer to salivary glands leads to abundant secretion of transgenic protein into either saliva or the bloodstream. This indicates significant clinical potential, depending on the route of sorting. The aim of this study was to probe the sorting characteristics of human parathyroid hormone (hPTH) in two animal models for salivary gland gene transfer. PTH is a key hormone regulating calcium levels in the blood. A recombinant serotype 5 adenoviral vector carrying the hPTH cDNA was administered to the submandibular glands of mice and rats. Two days after delivery, high levels of hPTH were found in the serum of mice, leading to elevated serum calcium levels. Only low amounts of hPTH were found in the saliva. Two days after vector infusion into rats, a massive secretion of hPTH was measured in saliva, with little secretion into serum. Confocal microscopy showed hPTH in the glands, localized basolaterally in mice and apically in rats. Submandibular gland transduction was effective and the produced hPTH was biologically active in vivo. Whereas hPTH sorted toward the basolateral side in mice, in rats hPTH was secreted mainly at the apical side. These results indicate that the interaction between hPTH and the cell sorting machinery is different between mouse and rat salivary glands. Detailed studies in these two species should result in a better understanding of cellular control of transgenic secretory protein sorting in this tissue. JF - Human Gene Therapy AU - Adriaansen, J AU - Perez, P AU - Goldsmith, C M AU - Zheng, C AU - Baum, B J AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Building 10, Room 1N113, MSC-1190, 10 Center Drive, Bethesda, MD 20892-1190, USA, adriaansenj@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1021 EP - 1028 VL - 19 IS - 10 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Protein transport KW - Calcium KW - Serotypes KW - Gene therapy KW - Secretion KW - Animal models KW - Probes KW - Salivary gland KW - Hormones KW - Calcium (blood) KW - Expression vectors KW - Blood KW - Confocal microscopy KW - Parathyroid hormone KW - Submandibular gland KW - Saliva KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19410054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Differential+Sorting+of+Human+Parathyroid+Hormone+After+Transduction+of+Mouse+and+Rat+Salivary+Glands&rft.au=Adriaansen%2C+J%3BPerez%2C+P%3BGoldsmith%2C+C+M%3BZheng%2C+C%3BBaum%2C+B+J&rft.aulast=Adriaansen&rft.aufirst=J&rft.date=2008-10-01&rft.volume=19&rft.issue=10&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2008.079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein transport; Serotypes; Calcium; Gene therapy; Secretion; Probes; Animal models; Salivary gland; Calcium (blood); Hormones; Expression vectors; Blood; Confocal microscopy; Parathyroid hormone; Submandibular gland; Saliva DO - http://dx.doi.org/10.1089/hum.2008.079 ER - TY - RPRT T1 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. [Part 1 of 2] T2 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. AN - 756825135; 13624-080398_0001 AB - PURPOSE: The adoption of an updated master development plan for the Rocky Mountain Laboratories (RML) campus of the National Institutes of Health (NIH) Main Campus in Hamilton, Ravalli County, Montana is proposed. The primary mission of NIH is to expand fundamental knowledge about the nature and behavior or living systems, to apply that knowledge to enhance the health of humans, and to reduce the burdens of disease and disability. If adopted, the proposed 20-year master plan, which would be reviewed quinquennially, would constitute part of a broad, long-term planning effort at the Department of Health and Human Services (HHS) and would fulfill a requirement of all HHS-administered campuses. The plan would provide a strategy for accommodating potential RML campus development subject to NIH and HHS priorities and the availability of resources. It also would serve as a guide for the development of individual projects, and assist local jurisdictions and utilities in anticipating and planning for infrastructure and systems as they relate to the needs of the RML. It would guide and coordinate the physical development of the RML campus with respect to siting of future construction, vehicular and pedestrian circulation on and off-campus, parking within the property boundaries, open space in and around the campus, required setbacks, historic properties management, natural and scenic resources, and noise and lighting; these considerations would respond to projected NIH administrative, research, and infrastructure support needs. Programming of future campus personnel and facilities was determined through an extensive series of interviews with NIH management and individual institute and center directorates. Three alternatives, including a No Action Alternative, which would retain the existing master plan and complete ongoing projects, are considered in this draft EIS. The proposed Alternative would expand the campus from 33 acres to 36 acres, expand the extent of developed areas from nine acres to 17 acres, and expand the occupiable building area from 323,805 gross square feet to 445,713 gross square feet. The principal features of the master plan would provide for campus upgrades, such as the demolition and replacement of obsolete buildings; construction of a central administration and storage building, which would represent much of the building area growth; expansion of parking facilities from a capacity of 400 spaces to a capacity of 461 spaces; modification of the Fifth Street access point; construction of a new long-term storage facility; installation of a new expanded perimeter fence; creation of a pedestrian core at the center of campus; and provision of landscaped open space throughout campus. POSITIVE IMPACTS: Plan implementation would significantly enhance the functional and social aspects of the NIH Bethesda Campus. Research facilities would be significantly upgraded and facility inadequacies would be corrected. The modified transportation system would provide enhance access within the campus, and landscaping and other aesthetic improvements would transform the somewhat dysfunctional campus into a pleasing and functionally adequate workplace. Utility line conflicts would be resolved. NEGATIVE IMPACTS: The extent of open, undisturbed area would decline from 24 acres to 19 acres. Increases in personnel using the site would place additional stress on the local transportation system within and outside the campus, utilities and waste management facilities, and energy sources. Construction activities, demolition of historically significant buildings, and new buildings and infrastructure would alter the visual appearance of the RML Historic District. JF - EPA number: 080398, Draft EIS--73 pages, Draft Master Plan--102 pages, September 26, 2008 PY - 2008 VL - 1 KW - Urban and Social Programs KW - Buildings KW - Demolition KW - Employment KW - Historic Districts KW - Historic Sites KW - Open Space KW - Parking KW - Research Facilities KW - Roads KW - Site Planning KW - Storage KW - Transportation KW - Vegetation KW - Visual Resources KW - Montana UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756825135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=Peter&rft.date=1981-09-14&rft.volume=128&rft.issue=6&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Forbes&rft.issn=00156914&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2008-12-30 N1 - SuppNotes - Draft. Preparation date: September 26, 2008 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. [Part 2 of 2] T2 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. AN - 756824817; 13624-080398_0002 AB - PURPOSE: The adoption of an updated master development plan for the Rocky Mountain Laboratories (RML) campus of the National Institutes of Health (NIH) Main Campus in Hamilton, Ravalli County, Montana is proposed. The primary mission of NIH is to expand fundamental knowledge about the nature and behavior or living systems, to apply that knowledge to enhance the health of humans, and to reduce the burdens of disease and disability. If adopted, the proposed 20-year master plan, which would be reviewed quinquennially, would constitute part of a broad, long-term planning effort at the Department of Health and Human Services (HHS) and would fulfill a requirement of all HHS-administered campuses. The plan would provide a strategy for accommodating potential RML campus development subject to NIH and HHS priorities and the availability of resources. It also would serve as a guide for the development of individual projects, and assist local jurisdictions and utilities in anticipating and planning for infrastructure and systems as they relate to the needs of the RML. It would guide and coordinate the physical development of the RML campus with respect to siting of future construction, vehicular and pedestrian circulation on and off-campus, parking within the property boundaries, open space in and around the campus, required setbacks, historic properties management, natural and scenic resources, and noise and lighting; these considerations would respond to projected NIH administrative, research, and infrastructure support needs. Programming of future campus personnel and facilities was determined through an extensive series of interviews with NIH management and individual institute and center directorates. Three alternatives, including a No Action Alternative, which would retain the existing master plan and complete ongoing projects, are considered in this draft EIS. The proposed Alternative would expand the campus from 33 acres to 36 acres, expand the extent of developed areas from nine acres to 17 acres, and expand the occupiable building area from 323,805 gross square feet to 445,713 gross square feet. The principal features of the master plan would provide for campus upgrades, such as the demolition and replacement of obsolete buildings; construction of a central administration and storage building, which would represent much of the building area growth; expansion of parking facilities from a capacity of 400 spaces to a capacity of 461 spaces; modification of the Fifth Street access point; construction of a new long-term storage facility; installation of a new expanded perimeter fence; creation of a pedestrian core at the center of campus; and provision of landscaped open space throughout campus. POSITIVE IMPACTS: Plan implementation would significantly enhance the functional and social aspects of the NIH Bethesda Campus. Research facilities would be significantly upgraded and facility inadequacies would be corrected. The modified transportation system would provide enhance access within the campus, and landscaping and other aesthetic improvements would transform the somewhat dysfunctional campus into a pleasing and functionally adequate workplace. Utility line conflicts would be resolved. NEGATIVE IMPACTS: The extent of open, undisturbed area would decline from 24 acres to 19 acres. Increases in personnel using the site would place additional stress on the local transportation system within and outside the campus, utilities and waste management facilities, and energy sources. Construction activities, demolition of historically significant buildings, and new buildings and infrastructure would alter the visual appearance of the RML Historic District. JF - EPA number: 080398, Draft EIS--73 pages, Draft Master Plan--102 pages, September 26, 2008 PY - 2008 VL - 2 KW - Urban and Social Programs KW - Buildings KW - Demolition KW - Employment KW - Historic Districts KW - Historic Sites KW - Open Space KW - Parking KW - Research Facilities KW - Roads KW - Site Planning KW - Storage KW - Transportation KW - Vegetation KW - Visual Resources KW - Montana UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756824817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-09-01&rft.volume=66&rft.issue=262&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Thought&rft.issn=00406457&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2008-12-30 N1 - SuppNotes - Draft. Preparation date: September 26, 2008 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay. AN - 69643784; 18822145 AB - The emergence of influenza strains that are resistant to commonly used antivirals has highlighted the need to develop new compounds that target viral gene products or host mechanisms that are essential for effective virus replication. Existing assays to identify potential antiviral compounds often use high throughput screening assays that target specific viral replication steps. To broaden the search for antivirals, cell-based replication assays can be performed, but these are often labor intensive and have limited throughput. We have adapted a traditional virus neutralization assay to develop a practical, cell-based, high throughput screening assay. This assay uses viral neuraminidase (NA) as a read-out to quantify influenza replication, thereby offering an assay that is both rapid and sensitive. In addition to identification of inhibitors that target either viral or host factors, the assay allows simultaneous evaluation of drug toxicity. Antiviral activity was demonstrated for a number of known influenza inhibitors including amantadine that targets the M2 ion channel, zanamivir that targets NA, ribavirin that targets IMP dehydrogenase, and bis-indolyl maleimide that targets protein kinase A/C. Amantadine-resistant strains were identified by comparing IC50 with that of the wild-type virus. Antivirals with specificity for a broad range of targets are easily identified in an accelerated viral inhibition assay that uses NA as a read-out of replication. This assay is suitable for high throughput screening to identify potential antivirals or can be used to identify drug-resistant influenza strains. JF - Virology journal AU - Eichelberger, Maryna C AU - Hassantoufighi, Arash AU - Wu, Meng AU - Li, Min AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA. Maryna.Eichelberger@fda.hhs.gov Y1 - 2008/09/26/ PY - 2008 DA - 2008 Sep 26 SP - 109 VL - 5 KW - Antiviral Agents KW - 0 KW - Enzyme Inhibitors KW - Viral Proteins KW - Neuraminidase KW - EC 3.2.1.18 KW - Index Medicus KW - Animals KW - Drug Resistance, Viral KW - Ducks KW - Virus Replication -- drug effects KW - Humans KW - Chick Embryo KW - Drug Evaluation, Preclinical KW - Viral Proteins -- genetics KW - Influenza B virus -- enzymology KW - Neuraminidase -- antagonists & inhibitors KW - Neuraminidase -- genetics KW - Influenza, Human -- virology KW - Influenza A virus -- drug effects KW - Influenza A virus -- enzymology KW - Influenza B virus -- drug effects KW - Antiviral Agents -- pharmacology KW - Neuraminidase -- metabolism KW - Viral Proteins -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Viral Proteins -- antagonists & inhibitors KW - Influenza, Human -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69643784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology+journal&rft.atitle=Neuraminidase+activity+provides+a+practical+read-out+for+a+high+throughput+influenza+antiviral+screening+assay.&rft.au=Litzinger%2C+William+D%3BSchaefer%2C+Thomas+E&rft.aulast=Litzinger&rft.aufirst=William&rft.date=1987-03-01&rft.volume=30&rft.issue=2&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Business+Horizons&rft.issn=00076813&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-06 N1 - Date created - 2008-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antiviral Res. 2007 Mar;73(3):228-31 [17112602] Pediatrics. 2006 Sep;118(3):e579-85 [16950949] Cell Physiol Biochem. 2007;20(1-4):75-82 [17595517] Int J Geriatr Psychiatry. 2007 Sep;22(9):935-6 [17721896] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18235-40 [17991777] Curr Pharm Des. 2007;13(34):3531-42 [18220789] Emerg Infect Dis. 2007 Sep;13(9):1354-7 [18252107] PLoS Pathog. 2008 Jul;4(7):e1000103 [18654625] Antiviral Res. 2002 Jan;53(1):47-61 [11684315] Antimicrob Agents Chemother. 2000 Apr;44(4):859-66 [10722482] Antimicrob Agents Chemother. 2008 Sep;52(9):3284-92 [18625765] J Virol Methods. 2004 Dec 1;122(1):9-15 [15488615] Science. 1972 Aug 25;177(4050):705-6 [4340949] Appl Microbiol. 1973 Feb;25(2):195-201 [4121031] Virology. 1974 Oct;61(2):397-410 [4472498] Anal Biochem. 1979 Apr 15;94(2):287-96 [464297] Pharmacol Ther. 1979;6(1):123-46 [390559] Cell. 1992 May 1;69(3):517-28 [1374685] Nature. 1993 Jun 3;363(6428):418-23 [8502295] Clin Diagn Lab Immunol. 1996 Sep;3(5):507-10 [8877126] Antiviral Res. 2005 Oct;68(1):10-7 [16087250] J Gen Virol. 2005 Oct;86(Pt 10):2823-30 [16186238] Lancet. 2005 Oct 1;366(9492):1175-81 [16198766] Emerg Infect Dis. 2005 Sep;11(9):1355-62 [16229762] Cell Microbiol. 2006 Mar;8(3):375-86 [16469051] Emerg Infect Dis. 2006 Jan;12(1):9-14 [16494710] Pediatr Infect Dis J. 2006 Jun;25(6):572 [16732168] J Biol Chem. 2006 Jun 16;281(24):16707-15 [16608852] J Infect Dis. 2007 Jul 15;196(2):249-57 [17570112] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1743-422X-5-109 ER - TY - JOUR T1 - Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. AN - 69461467; 18639561 AB - Genomic hypomethylation is a consistent finding in both human and animal tumors and mounting experimental evidence suggests a key role for epigenetic events in tumorigenesis. Furthermore, it has been suggested that early changes in DNA methylation and histone modifications may serve as sensitive predictive markers in animal testing for carcinogenic potency of environmental agents. Alterations in metabolism of methyl donors, disturbances in activity and/or expression of DNA methyltransferases, and presence of DNA single-strand breaks could contribute to the loss of cytosine methylation during carcinogenesis; however, the precise mechanisms of genomic hypomethylation induced by chemical carcinogens remain largely unknown. This study examined the mechanism of DNA hypomethylation during hepatocarcinogenesis induced by peroxisome proliferators WY-14,643 (4-chloro-6-(2,3-xylidino)-pyrimidynylthioacetic acid) and DEHP (di-(2-ethylhexyl)phthalate), agents acting through non-genotoxic mode of action. In the liver of male Fisher 344 rats exposed to WY-14,643 (0.1% (w/w), 5 months), the level of genomic hypomethylation increased by approximately 2-fold, as compared to age-matched controls, while in the DEHP group (1.2% (w/w), 5 months) DNA methylation did not change. Global DNA hypomethylation in livers from WY-14,643 group was accompanied by the accumulation of DNA single-strand breaks, increased cell proliferation, and diminished expression of DNA methyltransferase 1, while the metabolism of methyl donors was not affected. In contrast, none of these parameters changed significantly in rats fed DEHP. Since WY-14,643 is much more potent carcinogen than DEHP, we conclude that the extent of loss of DNA methylation may be related to the carcinogenic potential of the chemical agent, and that accumulation of DNA single-strand breaks coupled to the increase in cell proliferation and altered DNA methyltransferase expression may explain genomic hypomethylation during peroxisome proliferator-induced carcinogenesis. JF - Mutation research AU - Pogribny, Igor P AU - Tryndyak, Volodymyr P AU - Boureiko, Anna AU - Melnyk, Stepan AU - Bagnyukova, Tetyana V AU - Montgomery, Beverly AU - Rusyn, Ivan AD - Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. igor.pogribny@fda.hhs.gov Y1 - 2008/09/26/ PY - 2008 DA - 2008 Sep 26 SP - 17 EP - 23 VL - 644 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Histones KW - 0 KW - Mutagens KW - Peroxisome Proliferators KW - Proliferating Cell Nuclear Antigen KW - Pyrimidines KW - pirinixic acid KW - 86C4MRT55A KW - Diethylhexyl Phthalate KW - C42K0PH13C KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - DNA (cytosine-5-)-methyltransferase 1 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Diethylhexyl Phthalate -- toxicity KW - Histones -- chemistry KW - Mutagens -- toxicity KW - DNA (Cytosine-5-)-Methyltransferase -- metabolism KW - DNA Breaks, Single-Stranded KW - Rats KW - Rats, Inbred F344 KW - Histones -- metabolism KW - Pyrimidines -- toxicity KW - Methylation KW - Male KW - Proliferating Cell Nuclear Antigen -- metabolism KW - Liver -- drug effects KW - Peroxisome Proliferators -- toxicity KW - DNA Methylation -- drug effects KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69461467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Mechanisms+of+peroxisome+proliferator-induced+DNA+hypomethylation+in+rat+liver.&rft.au=Pogribny%2C+Igor+P%3BTryndyak%2C+Volodymyr+P%3BBoureiko%2C+Anna%3BMelnyk%2C+Stepan%3BBagnyukova%2C+Tetyana+V%3BMontgomery%2C+Beverly%3BRusyn%2C+Ivan&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2008-09-26&rft.volume=644&rft.issue=1-2&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrfmmm.2008.06.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-12 N1 - Date created - 2008-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Pharmacol Toxicol. 2002;42:501-25 [11807181] Toxicology. 2008 Apr 3;246(1):2-8 [18006136] Toxicol Sci. 2003 Oct;75(2):229-35 [12773759] Toxicol Sci. 2003 Oct;75(2):289-99 [12883089] J Nutr. 2003 Nov;133(11 Suppl 1):3740S-3747S [14608108] Cancer Sci. 2004 Jan;95(1):58-64 [14720328] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] Nat Rev Cancer. 2004 Feb;4(2):143-53 [14732866] Cancer Res. 2004 Feb 1;64(3):1050-7 [14871837] Science. 2004 Mar 12;303(5664):1626-32 [15016989] Toxicol Appl Pharmacol. 2004 May 1;196(3):422-30 [15094313] Life Sci. 1976 May 1;18(9):941-5 [1271963] Cancer Res. 1988 Dec 1;48(23):6739-44 [3180084] Carcinogenesis. 1993 Dec;14(12):2495-9 [8269617] DNA Cell Biol. 1996 Mar;15(3):255-62 [8634154] Mutat Res. 1997 Apr;386(2):141-52 [9113115] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10907-12 [9380733] Carcinogenesis. 1998 Aug;19(8):1487-94 [9744547] Biochem Biophys Res Commun. 1999 Sep 7;262(3):624-8 [10471374] Toxicol Sci. 2005 Oct;87(2):344-52 [16014735] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13580-5 [16174748] EXS. 2006;(96):321-49 [16383025] Genome Res. 2006 Feb;16(2):157-63 [16365381] Toxicol Sci. 2006 Apr;90(2):269-95 [16322072] Toxicol Sci. 2006 Jun;91(2):393-405 [16537655] Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11112-7 [16840560] Cancer Res. 2006 Sep 1;66(17):8462-9468 [16951157] Crit Rev Toxicol. 2006 May;36(5):459-79 [16954067] Biochim Biophys Acta. 2007 Jan;1775(1):138-62 [17045745] Cancer Res. 2007 Feb 1;67(3):946-50 [17283125] Mutat Res. 2007 Mar 1;616(1-2):7-10 [17147955] Cell. 2007 Feb 23;128(4):683-92 [17320506] Clin Cancer Res. 2007 Apr 15;13(8):2309-12 [17438087] Carcinogenesis. 2007 Jun;28(6):1171-7 [17331954] Nature. 2007 Jul 26;448(7152):445-51 [17597761] J Clin Invest. 2007 Sep;117(9):2713-22 [17717605] Int J Cancer. 2007 Dec 1;121(11):2410-20 [17680562] Mutat Res. 2007 Dec 1;625(1-2):62-71 [17586532] Carcinogenesis. 2007 Dec;28(12):2434-42 [17893234] Oncogene. 2008 Jan 10;27(3):404-8 [17621273] Chem Res Toxicol. 2008 Jan;21(1):28-44 [17970581] Environ Mol Mutagen. 2008 Jan;49(1):9-15 [17879298] Cell. 2000 Jan 7;100(1):57-70 [10647931] Clin Chem. 2000 Feb;46(2):265-72 [10657384] Cancer Res. 2000 Feb 1;60(3):588-94 [10676641] Drug Metab Rev. 2000 May;32(2):211-4 [10774776] Carcinogenesis. 2000 Dec;21(12):2141-5 [11133801] Toxicol Sci. 2001 Jul;62(1):28-35 [11399790] Mol Cell Biol. 2002 Jan;22(2):480-91 [11756544] Epigenetics. 2007 Oct-Dec;2(4):223-6 [18032927] Carcinogenesis. 2003 Jan;24(1):39-45 [12538347] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrfmmm.2008.06.009 ER - TY - JOUR T1 - beta-Estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL. AN - 69612789; 18808673 AB - Female hormones are known to play an important role in predisposition for many infectious diseases. Recent work suggests there are gender effects in HIV/AIDS progression. Here we ask whether the sex steroid hormone beta-estradiol affects the replication of HIV-1 or the efficacy of a common anti-retroviral drug, Stavudine (D4T). Human PBL were infected with HIV-1 in the presence or absence of combinations of sex steroid hormones and the anti-retroviral drug, D4T. After seven days in culture, viral supernatants were assayed for HIV-1 p24 protein. beta-estradiol resulted in a modest inhibition of HIV-1 replication of approximately 26%. However, 2 nM beta-estradiol increased the amount of HIV-1 replication in the presence of 50 nM D4T from a baseline of 33% (+/- SE = 5.4) to 74% (+/- SE = 5.4) of control virus levels in the absence of drug. Both results were statistically highly significant (p < 0.001). beta-estradiol did not increase the replication of a D4T-resistant strain of HIV in the presence of D4T. The effects were unlikely to be due to general cell inhibition or toxicity because these concentrations of drug and hormone cause no cytotoxicity in PBL as measured by trypan blue exclusion. beta-estradiol inhibited both HIV-1 replication in primary human PBL and the antiretroviral efficacy of D4T in PBL cultures. To optimize antiretroviral drug therapy, it may be necessary to monitor patient hormonal status. JF - Retrovirology AU - Zhang, Mingjie AU - Huang, Qingsheng AU - Huang, Yong AU - Wood, Owen AU - Yuan, Weishi AU - Chancey, Caren AU - Daniel, Sylvester AU - Rios, Maria AU - Hewlett, Indira AU - Clouse, Kathleen A AU - Dayton, Andrew I AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. ming.zhang@fda.hhs.gov Y1 - 2008/09/22/ PY - 2008 DA - 2008 Sep 22 SP - 82 VL - 5 KW - Anti-HIV Agents KW - 0 KW - Culture Media KW - Gonadal Steroid Hormones KW - HIV Core Protein p24 KW - Estradiol KW - 4TI98Z838E KW - Stavudine KW - BO9LE4QFZF KW - Index Medicus KW - Drug Interactions KW - Virus Replication -- drug effects KW - Cells, Cultured KW - Humans KW - HIV Core Protein p24 -- biosynthesis KW - Female KW - Lymphocytes -- virology KW - Culture Media -- chemistry KW - Gonadal Steroid Hormones -- pharmacology KW - Anti-HIV Agents -- pharmacology KW - Stavudine -- pharmacology KW - Estradiol -- pharmacology KW - HIV-1 -- growth & development KW - HIV-1 -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69612789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Retrovirology&rft.atitle=beta-Estradiol+attenuates+the+anti-HIV-1+efficacy+of+Stavudine+%28D4T%29+in+primary+PBL.&rft.au=Zhang%2C+Mingjie%3BHuang%2C+Qingsheng%3BHuang%2C+Yong%3BWood%2C+Owen%3BYuan%2C+Weishi%3BChancey%2C+Caren%3BDaniel%2C+Sylvester%3BRios%2C+Maria%3BHewlett%2C+Indira%3BClouse%2C+Kathleen+A%3BDayton%2C+Andrew+I&rft.aulast=Zhang&rft.aufirst=Mingjie&rft.date=2008-09-22&rft.volume=5&rft.issue=&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Retrovirology&rft.issn=1742-4690&rft_id=info:doi/10.1186%2F1742-4690-5-82 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-06 N1 - Date created - 2008-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Hum Virol. 2001 May-Jun;4(3):113-22 [11572234] J Bioenerg Biomembr. 2000 Jun;32(3):317-24 [11768316] AIDS Patient Care STDS. 2002 May;16(5):211-21 [12055029] Clin Infect Dis. 2002 Aug 1;35(3):313-22 [12115098] Eur J Obstet Gynecol Reprod Biol. 2003 Aug 15;109(2):199-205 [12860342] Expert Opin Drug Metab Toxicol. 2006 Apr;2(2):273-83 [16866613] J Exp Med. 1989 Mar 1;169(3):933-51 [2538549] Antimicrob Agents Chemother. 1989 Jun;33(6):844-9 [2764535] AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1235-42 [9310291] J Infect Dis. 1998 Aug;178(2):413-22 [9697721] J Gen Intern Med. 2004 Nov;19(11):1111-7 [15566440] Biochem Pharmacol. 1988 Dec 1;37(23):4419-22 [2849444] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1742-4690-5-82 ER - TY - JOUR T1 - Risk of Cataract after Exposure to Low Doses of Ionizing Radiation: A 20-Year Prospective Cohort Study among US Radiologic Technologists AN - 19581934; 8534127 AB - The study aim was to determine the risk of cataract among radiologic technologists with respect to occupational and nonoccupational exposures to ionizing radiation and to personal characteristics. A prospective cohort of 35,705 cataract-free US radiologic technologists aged 24-44 years was followed for nearly 20 years (1983-2004) by using two follow-up questionnaires. During the study period, 2,382 cataracts and 647 cataract extractions were reported. Cigarette smoking for .5 pack-years; body mass index of .25 kg/m2 ; and history of diabetes, hypertension, hypercholesterolemia, or arthritis at baseline were significantly (p [lE] 0.05) associated with increased risk of cataract. In multivariate models, self-report of .3 x-rays to the face/neck was associated with a hazard ratio of cataract of 1.25 (95% confidence interval: 1.06, 1.47). For workers in the highest category (mean, 60 mGy) versus lowest category (mean, 5 mGy) of occupational dose to the lens of the eye, the adjusted hazard ratio of cataract was 1.18 (95% confidence interval: 0.99, 1.40). Findings challenge the National Council on Radiation Protection and International Commission on Radiological Protection assumptions that the lowest cumulative ionizing radiation dose to the lens of the eye that can produce a progressive cataract is approximately 2 Gy, and they support the hypothesis that the lowest cataractogenic dose in humans is substantially less than previously thought. JF - American Journal of Epidemiology AU - Chodick, Gabriel AU - Bekiroglu, Nural AU - Hauptmann, Michael AU - Alexander, Bruce H AU - Freedman, DMichal AU - Doody, Michele Morin AU - Cheung, Li C AU - Simon, Steven L AU - Weinstock, Robert M AU - Bouville, AndrE AU - Sigurdson, Alice J AD - 1 Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, hodik_g@mac.org.il Y1 - 2008/09/15/ PY - 2008 DA - 2008 Sep 15 SP - 620 EP - 631 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street VL - 168 IS - 6 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - cataract KW - radiation KW - technology, radiologic KW - x-rays KW - Historical account KW - Eye KW - Eye lens KW - Models KW - commissions KW - Workers KW - diabetes mellitus KW - body mass KW - Arthritis KW - Cigarette smoking KW - Hypercholesterolemia KW - Occupational exposure KW - Inventories KW - Cataracts KW - cataracts KW - Neck KW - Diabetes mellitus KW - USA KW - Ionizing radiation KW - councils KW - hypertension KW - Body mass index KW - Hypertension KW - X 24390:Radioactive Materials KW - R2 23080:Industrial and labor KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19581934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Risk+of+Cataract+after+Exposure+to+Low+Doses+of+Ionizing+Radiation%3A+A+20-Year+Prospective+Cohort+Study+among+US+Radiologic+Technologists&rft.au=Chodick%2C+Gabriel%3BBekiroglu%2C+Nural%3BHauptmann%2C+Michael%3BAlexander%2C+Bruce+H%3BFreedman%2C+DMichal%3BDoody%2C+Michele+Morin%3BCheung%2C+Li+C%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BBouville%2C+AndrE%3BSigurdson%2C+Alice+J&rft.aulast=Chodick&rft.aufirst=Gabriel&rft.date=2008-09-15&rft.volume=168&rft.issue=6&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwn171 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inventories; Cataracts; Eye lens; Neck; Models; Diabetes mellitus; Workers; Arthritis; Ionizing radiation; Cigarette smoking; Body mass index; Hypercholesterolemia; Occupational exposure; Hypertension; commissions; Historical account; diabetes mellitus; Eye; body mass; cataracts; hypertension; councils; USA DO - http://dx.doi.org/10.1093/aje/kwn171 ER - TY - JOUR T1 - Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury. AN - 69364162; 18586006 AB - Recent studies in mice suggest that stress-activated c-Jun N-terminal protein kinase 2 (JNK2) plays a pathologic role in acetaminophen (APAP)-induced liver injury (AILI), a major cause of acute liver failure (ALF). In contrast, we present evidence that JNK2 can have a protective role against AILI. When male C57BL/6J wild type (WT) and JNK2(-/-) mice were treated with 300mg APAP/kg, 90% of JNK2(-/-) mice died of ALF compared to 20% of WT mice within 48h. The high susceptibility of JNK2(-/-) mice to AILI appears to be due in part to deficiencies in hepatocyte proliferation and repair. Therefore, our findings are consistent with JNK2 signaling playing a protective role in AILI and further suggest that the use of JNK inhibitors as a potential treatment for AILI, as has been recommended by other investigators, should be reconsidered. JF - Biochemical and biophysical research communications AU - Bourdi, Mohammed AU - Korrapati, Midhun C AU - Chakraborty, Mala AU - Yee, Steven B AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1760, USA. bourdim@nih.gov Y1 - 2008/09/12/ PY - 2008 DA - 2008 Sep 12 SP - 6 EP - 10 VL - 374 IS - 1 KW - Analgesics, Non-Narcotic KW - 0 KW - Cyclin D KW - Cyclins KW - Acetaminophen KW - 362O9ITL9D KW - Mitogen-Activated Protein Kinase 9 KW - EC 2.7.1.24 KW - Index Medicus KW - Animals KW - Mice, Mutant Strains KW - Cyclins -- metabolism KW - Mice KW - Liver Regeneration -- genetics KW - Male KW - Mitogen-Activated Protein Kinase 9 -- genetics KW - Liver Failure, Acute -- genetics KW - Liver Failure, Acute -- chemically induced KW - Liver -- pathology KW - Liver -- enzymology KW - Liver -- drug effects KW - Mitogen-Activated Protein Kinase 9 -- physiology KW - Analgesics, Non-Narcotic -- toxicity KW - Liver Failure, Acute -- enzymology KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69364162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Protective+role+of+c-Jun+N-terminal+kinase+2+in+acetaminophen-induced+liver+injury.&rft.au=Bourdi%2C+Mohammed%3BKorrapati%2C+Midhun+C%3BChakraborty%2C+Mala%3BYee%2C+Steven+B%3BPohl%2C+Lance+R&rft.aulast=Bourdi&rft.aufirst=Mohammed&rft.date=2008-09-12&rft.volume=374&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=1090-2104&rft_id=info:doi/10.1016%2Fj.bbrc.2008.06.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-25 N1 - Date created - 2008-07-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Pharmacol. 1987 Apr 15;36(8):1193-6 [3593409] Hepatology. 2004 Jul;40(1):23-6 [15239082] J Clin Invest. 1995 Feb;95(2):803-10 [7860764] EMBO J. 1999 Jan 4;18(1):188-97 [9878062] Br J Pharmacol. 1999 Aug;127(7):1589-96 [10455314] Endocrinology. 2004 Dec;145(12):5439-47 [15331580] Toxicol Pathol. 2005;33(1):41-51 [15805055] Nat Rev Drug Discov. 2005 Jun;4(6):489-99 [15931258] Toxicol Sci. 2006 Jan;89(1):31-41 [16177235] Life Sci. 2006 Mar 6;78(15):1670-6 [16226279] Gastroenterology. 2006 Jul;131(1):165-78 [16831600] Gastroenterology. 2006 Jul;131(1):314-6 [16831613] Transplantation. 2006 Jul 27;82(2):241-50 [16858288] Exp Mol Med. 2006 Aug 31;38(4):408-16 [16953120] Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1536-44 [16489107] Mol Cell. 2006 Sep 15;23(6):899-911 [16973441] J Biochem Mol Biol. 2006 Sep 30;39(5):479-91 [17002867] Microbiol Mol Biol Rev. 2006 Dec;70(4):1061-95 [17158707] Chem Res Toxicol. 2007 Feb;20(2):208-16 [17305405] Hepatology. 2007 Feb;45(2):412-21 [17366662] Eur J Pharmacol. 2007 Jun 14;564(1-3):190-5 [17395177] Chem Res Toxicol. 2007 May;20(5):734-44 [17439248] Gut. 2007 Jul;56(7):982-90 [17185352] J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):160-5 [17616004] J Cell Physiol. 2007 Nov;213(2):286-300 [17559071] J Biol Chem. 2008 May 16;283(20):13565-77 [18337250] Hepatology. 2008 Sep;48(3):889-97 [18712839] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4611-6 [11287661] J Pharmacol Exp Ther. 2001 Jun;297(3):946-52 [11356915] Hepatology. 2002 Feb;35(2):289-98 [11826401] Biochem Biophys Res Commun. 2002 Jun 7;294(2):225-30 [12051698] Toxicol Appl Pharmacol. 2002 Jun 1;181(2):106-15 [12051994] FASEB J. 2002 Aug;16(10):1227-36 [12153990] Biochem J. 2003 Apr 1;371(Pt 1):199-204 [12534346] Hepatology. 2003 Apr;37(4):824-32 [12668975] Am J Physiol Gastrointest Liver Physiol. 2003 Jun;284(6):G875-9 [12736142] J Biol Chem. 2003 Jun 20;278(25):22243-9 [12646564] Toxicol Lett. 2003 Oct 15;144(3):279-88 [12927346] Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G959-66 [12842828] Drug Metab Dispos. 2003 Dec;31(12):1499-506 [14625346] Biochim Biophys Acta. 2004 Mar 11;1697(1-2):89-101 [15023353] Hepatology. 2004 May;39(5):1267-76 [15122755] Cancer Treat Res. 2004;119:217-37 [15164880] Cancer Lett. 1991 Sep;59(3):251-6 [1680544] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbrc.2008.06.065 ER - TY - JOUR T1 - Introducing Black-Gold II, a highly soluble gold phosphate complex with several unique advantages for the histochemical localization of myelin. AN - 69465846; 18657520 AB - A novel gold phosphate complex called Black-Gold II with improved myelin staining properties has been developed. It differs from its predecessor, Black-Gold, in that it is highly water soluble at room temperature. This unique physical property confers a number of advantages for the high resolution staining of myelinated fibers. Specifically, it 1) allows for easier solution preparation, eliminating the need for extended heating or sonicating; 2) produces a more uniform and consistent tracer concentration, resulting in more consistent staining and 3) can be used at a 50% higher concentration, resulting in faster and more intense staining without the need for subsequent treatment with gold chloride intensifiers. To characterize the stain, both normal rat brains as well as those exposed to the neurotoxins kainic acid or methamphetamine were examined. The study also incorporates the first application of such stains to examine peripheral nerves of control and acrylamide-exposed rats. JF - Brain research AU - Schmued, Larry AU - Bowyer, John AU - Cozart, Matthew AU - Heard, David AU - Binienda, Zbigniew AU - Paule, Merle AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson AR 72079, USA. larry.schmued@fda.hhs.gov Y1 - 2008/09/10/ PY - 2008 DA - 2008 Sep 10 SP - 210 EP - 217 VL - 1229 SN - 0006-8993, 0006-8993 KW - Black-Gold KW - 0 KW - Fluoresceins KW - Organic Chemicals KW - Phosphates KW - fluoro jade KW - Amphetamine KW - CK833KGX7E KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Rats KW - Animals KW - Nerve Degeneration -- complications KW - Myelin Sheath -- pathology KW - Nerve Degeneration -- metabolism KW - Peripheral Nervous System Diseases -- pathology KW - Nerve Degeneration -- pathology KW - Myelin Sheath -- metabolism KW - Peripheral Nervous System Diseases -- chemically induced KW - Peripheral Nervous System Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69465846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Introducing+Black-Gold+II%2C+a+highly+soluble+gold+phosphate+complex+with+several+unique+advantages+for+the+histochemical+localization+of+myelin.&rft.au=Schmued%2C+Larry%3BBowyer%2C+John%3BCozart%2C+Matthew%3BHeard%2C+David%3BBinienda%2C+Zbigniew%3BPaule%2C+Merle&rft.aulast=Schmued&rft.aufirst=Larry&rft.date=2008-09-10&rft.volume=1229&rft.issue=&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2008.06.129 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-03 N1 - Date created - 2008-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2008.06.129 ER - TY - JOUR T1 - Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume. AN - 733743203; 18778475 AB - Welding fume has been categorized as "possibly carcinogenic" to humans. Our objectives were to characterize the lung response to carcinogenic and non-carcinogenic metal-containing welding fumes and to determine if these fumes caused increased lung tumorigenicity in A/J mice, a lung tumor susceptible strain. We exposed male A/J and C57BL/6J, a lung tumor resistant strain, by pharyngeal aspiration four times (once every 3 days) to 85 mug of gas metal arc-mild steel (GMA-MS), GMA-stainless steel (SS), or manual metal arc-SS (MMA-SS) fume, or to 25.5 mug soluble hexavalent chromium (S-Cr). Shams were exposed to saline vehicle. Bronchoalveolar lavage (BAL) was done at 2, 7, and 28 days post-exposure. For the lung tumor study, gross tumor counts and histopathological changes were assessed in A/J mice at 48 and 78 weeks post-exposure. BAL revealed notable strain-dependent differences with regards to the degree and resolution of the inflammatory response after exposure to the fumes. At 48 weeks, carcinogenic metal-containing GMA-SS fume caused the greatest increase in tumor multiplicity and incidence, but this was not different from sham. By 78 weeks, tumor incidence in the GMA-SS group versus sham approached significance (p = 0.057). A significant increase in perivascular/peribronchial lymphoid infiltrates for the GMA-SS group versus sham and an increased persistence of this fume in lung cells compared to the other welding fumes was found. The increased persistence of GMA-SS fume in combination with its metal composition may trigger a chronic, but mild, inflammatory state in the lung possibly enhancing tumorigenesis in this susceptible mouse strain. JF - Particle and fibre toxicology AU - Zeidler-Erdely, Patti C AU - Kashon, Michael L AU - Battelli, Lori A AU - Young, Shih-Houng AU - Erdely, Aaron AU - Roberts, Jenny R AU - Reynolds, Steven H AU - Antonini, James M AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA. paz9@cdc.gov. Y1 - 2008/09/08/ PY - 2008 DA - 2008 Sep 08 SP - 12 VL - 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733743203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Pulmonary+inflammation+and+tumor+induction+in+lung+tumor+susceptible+A%2FJ+and+resistant+C57BL%2F6J+mice+exposed+to+welding+fume.&rft.au=Zeidler-Erdely%2C+Patti+C%3BKashon%2C+Michael+L%3BBattelli%2C+Lori+A%3BYoung%2C+Shih-Houng%3BErdely%2C+Aaron%3BRoberts%2C+Jenny+R%3BReynolds%2C+Steven+H%3BAntonini%2C+James+M&rft.aulast=Zeidler-Erdely&rft.aufirst=Patti&rft.date=2008-09-08&rft.volume=5&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-5-12 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2008-09-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Med Chem. 2007;14(12):1279-89 [17504213] Toxicol Appl Pharmacol. 2007 Sep 15;223(3):234-45 [17706736] J Occup Environ Hyg. 2006 Apr;3(4):194-203; quiz D45 [16531292] Mol Cell Biochem. 2005 Nov;279(1-2):17-23 [16283511] Genes Dev. 2005 Mar 15;19(6):643-64 [15769940] J Natl Cancer Inst. 1999 Apr 21;91(8):675-90 [10218505] Int J Occup Environ Health. 1998 Apr-Jun;4(2):85-8 [10026469] Toxicol Lett. 1998 Sep 1;98(1-2):77-86 [9776564] Exp Lung Res. 1998 Jul-Aug;24(4):541-55 [9659582] Carcinogenesis. 1997 Oct;18(10):1917-20 [9364000] Scand J Work Environ Health. 1997 Apr;23(2):104-13 [9167233] Int J Radiat Biol. 1997 Mar;71(3):301-8 [9134020] Carcinogenesis. 1997 Mar;18(3):531-7 [9067553] Am J Ind Med. 1996 Oct;30(4):383-91 [8892542] Toxicol Appl Pharmacol. 1996 Sep;140(1):188-99 [8806885] Cancer Res. 1996 May 1;56(9):2224-8 [8616876] Toxicol Pathol. 1991;19(2):168-75 [1771369] Cancer Res. 1992 Jun 1;52(11):3164-73 [1591728] Exp Lung Res. 1991 Mar-Apr;17(2):157-68 [2050022] Am Rev Respir Dis. 1991 May;143(5 Pt 1):1134-48 [2024826] IARC Monogr Eval Carcinog Risks Hum. 1990;49:1-648 [2232124] Toxicol Pathol. 1989;17(4 Pt 2):737-42 [2483278] J Natl Cancer Inst. 1987 Apr;78(4):743-9 [3470549] Exp Pathol. 1986;30(3):129-41 [3792485] J Natl Cancer Inst. 1985 Nov;75(5):963-9 [3863993] Toxicol Lett. 1982 Apr;11(1-2):159-63 [6896394] Scand J Work Environ Health. 1977 Dec;3(4):203-11 [339336] Mutat Res. 1978 Jan;56(3):235-43 [342941] Adv Cancer Res. 1975;21:1-58 [1108612] Toxicol Sci. 2004 Sep;81(1):26-34 [15159525] Cancer Res. 2004 Apr 1;64(7):2307-16 [15059877] Inhal Toxicol. 2004 Jan;16(1):27-32 [14744662] Toxicol Sci. 2003 Sep;75(1):181-91 [12832661] J Toxicol Environ Health A. 2003 Aug 8;66(15):1441-52 [12857634] Crit Rev Toxicol. 2003;33(1):61-103 [12585507] Scand J Work Environ Health. 2002 Jun;28(3):163-7 [12109555] Respir Res. 2000;1(3):163-9 [11667981] Methods. 2001 Dec;25(4):402-8 [11846609] Anticancer Res. 2001 May-Jun;21(3B):1749-55 [11497255] Cancer Res. 2000 Sep 15;60(18):5017-20 [11016621] J Toxicol Environ Health A. 1999 Nov 26;58(6):343-63 [10580758] Carcinogenesis. 2000 Apr;21(4):533-41 [10753182] J Immunol Methods. 2008 Feb 29;331(1-2):59-68 [18089291] Scand J Work Environ Health. 2007 Oct;33(5):379-86 [17973064] Toxicol Pathol. 2006;34(4):364-72 [16844664] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1743-8977-5-12 ER - TY - CPAPER T1 - Monitoring of Nutrition Labeling and Determination of Ascorbic acid and Calcium in Fortified Food T2 - 15th International Congress of Dietetics (ICD 2008) AN - 41096117; 4939793 JF - 15th International Congress of Dietetics (ICD 2008) AU - Jang, Jin-Wook Y1 - 2008/09/08/ PY - 2008 DA - 2008 Sep 08 KW - Nutrition KW - Calcium KW - Food KW - Ascorbic acid KW - Vitamin C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41096117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Congress+of+Dietetics+%28ICD+2008%29&rft.atitle=Monitoring+of+Nutrition+Labeling+and+Determination+of+Ascorbic+acid+and+Calcium+in+Fortified+Food&rft.au=Jang%2C+Jin-Wook&rft.aulast=Jang&rft.aufirst=Jin-Wook&rft.date=2008-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Congress+of+Dietetics+%28ICD+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ics-inc.co.jp/icd2008/5top.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Acetylcholine release in the mesocorticolimbic dopamine system during cocaine seeking: conditioned and unconditioned contributions to reward and motivation. AN - 69513157; 18768696 AB - Microdialysis was used to assess the contribution to cocaine seeking of cholinergic input to the mesocorticolimbic dopamine system in ventral tegmental area (VTA). VTA acetylcholine (ACh) was elevated in animals lever pressing for intravenous cocaine and in cocaine-experienced and cocaine-naive animals passively receiving similar "yoked" injections. In cocaine-trained animals, the elevations comprised an initial (first hour) peak to approximately 160% of baseline and a subsequent plateau of 140% of baseline for the rest of the cocaine intake period. In cocaine-naive animals, yoked cocaine injections raised ACh levels to the 140% plateau but did not cause the initial 160% peak. In cocaine-trained animals that received unexpected saline (extinction conditions) rather than the expected cocaine, the initial peak was seen but the subsequent plateau was absent. VTA ACh levels played a causal role and were not just a correlate of cocaine seeking. Blocking muscarinic input to the VTA increased cocaine intake; the increase in intake offset the decrease in cholinergic input, resulting in the same VTA dopamine levels as were seen in the absence of the ACh antagonists. Increased VTA ACh levels (resulting from 10 microM VTA neostigmine infusion) increased VTA dopamine levels and reinstated cocaine seeking in cocaine-trained animals that had undergone extinction; these effects were strongly attenuated by local infusion of a muscarinic antagonist and weakly attenuated by a nicotinic antagonist. These findings identify two cholinergic responses to cocaine self-administration, an unconditioned response to cocaine itself and a conditioned response triggered by cocaine-predictive cues, and confirm that these cholinergic responses contribute to the control of cocaine seeking. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - You, Zhi-Bing AU - Wang, Bin AU - Zitzman, Dawnya AU - Wise, Roy A AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. zyou@intra.nida.nih.gov Y1 - 2008/09/03/ PY - 2008 DA - 2008 Sep 03 SP - 9021 EP - 9029 VL - 28 IS - 36 KW - Cholinergic Antagonists KW - 0 KW - Mecamylamine KW - 6EE945D3OK KW - Atropine KW - 7C0697DR9I KW - Cocaine KW - I5Y540LHVR KW - Acetylcholine KW - N9YNS0M02X KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Extinction, Psychological KW - Rats, Long-Evans KW - Substantia Nigra -- drug effects KW - Mecamylamine -- pharmacology KW - Cholinergic Antagonists -- pharmacology KW - Cocaine -- administration & dosage KW - Microdialysis -- methods KW - Substantia Nigra -- metabolism KW - Rats KW - Self Administration -- methods KW - Behavior, Animal -- physiology KW - Atropine -- pharmacology KW - Male KW - Acetylcholine -- metabolism KW - Reward KW - Motivation KW - Conditioning (Psychology) -- physiology KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- physiopathology KW - Dopamine -- metabolism KW - Ventral Tegmental Area -- metabolism KW - Ventral Tegmental Area -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69513157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Acetylcholine+release+in+the+mesocorticolimbic+dopamine+system+during+cocaine+seeking%3A+conditioned+and+unconditioned+contributions+to+reward+and+motivation.&rft.au=You%2C+Zhi-Bing%3BWang%2C+Bin%3BZitzman%2C+Dawnya%3BWise%2C+Roy+A&rft.aulast=You&rft.aufirst=Zhi-Bing&rft.date=2008-09-03&rft.volume=28&rft.issue=36&rft.spage=9021&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.0694-08.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-16 N1 - Date created - 2008-09-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 1996 Aug 19;730(1-2):133-42 [8883897] Brain Res. 1999 Aug 21;839(1):85-93 [10482802] Nature. 1997 Nov 27;390(6658):401-4 [9389479] J Neurosci. 1998 Jul 1;18(13):5035-44 [9634569] J Comp Neurol. 2005 Mar 7;483(2):217-35 [15678476] J Neurosci. 2000 Feb 15;20(4):1635-42 [10662853] Pharmacol Biochem Behav. 2000 Mar;65(3):375-9 [10683476] J Neurosci. 2000 Oct 1;20(19):7489-95 [11007908] Eur J Neurosci. 2000 Oct;12(10):3596-604 [11029630] J Neurosci. 2001 Mar 1;21(5):1452-63 [11222635] J Neurosci. 2001 Aug 1;21(15):5841-6 [11466456] Neuroscience. 2001;106(3):633-41 [11591463] J Neurosci. 2002 Jan 1;22(1):RC190 [11756520] J Neurosci. 2002 Jul 15;22(14):6247-53 [12122083] Eur J Pharmacol. 2003 Sep 5;477(1):37-44 [14512096] J Neurosci. 2003 Oct 15;23(28):9305-11 [14561857] Psychopharmacology (Berl). 2004 Aug;175(1):53-9 [14767633] J Pharmacol Exp Ther. 1968 May;161(1):122-9 [5648489] J Comp Physiol Psychol. 1969 May;68(1):22-30 [5798120] Psychopharmacologia. 1974 Jan 14;34(3):255-64 [4819978] Biochem Pharmacol. 1975 Apr 15;24(8):847-52 [1125084] Nature. 1976 Mar 18;260(5548):258-60 [1256567] Can J Psychol. 1977 Dec;31(4):195-203 [608135] Brain Res. 1980 Mar 3;185(1):1-15 [7353169] Brain Res. 1981 May 25;213(1):190-4 [7016258] Science. 1983 Aug 19;221(4612):773-5 [6879176] Brain Res. 1985 Mar 11;329(1-2):19-26 [3872153] Brain Res. 1985 Dec 2;348(2):355-8 [4075093] Neurosci Lett. 1986 May 23;66(3):281-6 [2425289] Brain Res Bull. 1986 May;16(5):603-37 [3742247] Neuroscience. 1986 Oct;19(2):551-64 [3774154] Acta Physiol Scand. 1986 Nov;128(3):351-8 [3788613] Eur J Pharmacol. 1987 Sep 23;141(3):395-9 [3666033] J Neurosci. 1988 Jan;8(1):100-12 [3339402] Neuroscience. 1989;28(3):611-23 [2710334] Pharmacol Biochem Behav. 1989 Feb;32(2):527-31 [2727015] Pharmacol Biochem Behav. 1988 Nov;31(3):547-59 [3251239] J Comp Neurol. 1989 Jun 8;284(2):314-35 [2754038] J Neurosci. 1989 Oct;9(10):3400-9 [2795130] Pharmacol Biochem Behav. 1989 Dec;34(4):899-904 [2623043] J Neurosci. 1990 Aug;10(8):2541-59 [2388079] Neurosci Lett. 1990 Jul 3;114(2):154-9 [2395528] Synapse. 1990;6(1):106-12 [1697988] Proc Natl Acad Sci U S A. 1990 Sep;87(18):7050-4 [2402490] Brain Res. 1990 Aug 27;526(1):45-53 [2078817] Neuroscience. 1991;41(2-3):483-94 [1678502] Synapse. 1994 Jan;16(1):36-44 [8134899] Pharmacol Toxicol. 1994 Dec;75(6):348-52 [7534921] J Neurosci. 1995 Sep;15(9):5859-69 [7666171] Psychopharmacology (Berl). 1995 Jul;120(1):10-20 [7480530] J Neurosci. 1996 Jan 15;16(2):714-22 [8551354] J Comp Neurol. 1995 Dec 11;363(2):177-96 [8642069] Psychopharmacology (Berl). 1995 Nov;122(2):194-7 [8848536] J Comp Neurol. 1996 Jan 8;364(2):254-66 [8788248] J Neurosci. 2005 May 11;25(19):4725-32 [15888648] J Comp Neurol. 2006 Feb 20;494(6):863-75 [16385486] Brain Res. 2006 Oct 20;1116(1):143-52 [16942754] J Neurosci. 2007 May 23;27(21):5730-43 [17522317] J Neurosci. 2007 Sep 26;27(39):10546-55 [17898226] Neuroreport. 2008 Jun 11;19(9):991-5 [18521007] Synapse. 1999 Mar 15;31(4):241-9 [10051104] Pharmacol Biochem Behav. 1997 Aug;57(4):915-21 [9259024] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.0694-08.2008 ER - TY - JOUR T1 - Body size and the risk of biliary tract cancer: a population-based study in China AN - 19607504; 8586559 AB - Though obesity is an established risk factor for gall bladder cancer, its role in cancers of the extrahepatic bile ducts and ampulla of Vater is less clear, as also is the role of abdominal obesity. In a population-based case-control study of biliary tract cancer in Shanghai, China, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for biliary tract cancer in relation to anthropometric measures, including body mass index (BMI) at various ages and waist-to-hip ratio (WHR), adjusting for age, sex, and education. The study included 627 patients with biliary tract cancer (368 gall bladder, 191 bile duct, 68 ampulla of Vater) and 959 healthy subjects randomly selected from the population. A higher BMI at all ages, including early adulthood (ages 20-29 years), and a greater WHR were associated with an increased risk of gall bladder cancer. A high usual adult BMI ( greater than or equal to 25) was associated with a 1.6-fold risk of gall bladder cancer (95% CI 1.2-2.1, P fortrend 0.90) having the highest risk of gall bladder cancer (OR= 12.6, 95% CI 4.8-33.2), relative to those with a low BMI and WHR We found no clear risk patterns for cancers of the bile duct and ampulla of Vater. These results suggest that both overall and abdominal obesity, including obesity in early adulthood, are associated with an increased risk of gall bladder cancer. The increasing prevalence of obesity and cholesterol stones in Shanghai seems at least partly responsible for the rising incidence of gall bladder cancer in Shanghai. JF - British Journal of Cancer AU - Hsing, A W AU - Sakoda, L C AU - Rashid, A AU - Chen, J AU - Shen, M C AU - Han, T Q AU - Wang, B S AU - Gao, Y T AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd. EPS 5024, Bethesda, MD 20892-7324, USA, hsinga@mail.nih.gov Y1 - 2008/09/02/ PY - 2008 DA - 2008 Sep 02 SP - 811 EP - 815 VL - 99 IS - 5 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Age KW - obesity KW - body size KW - cholesterol KW - Cancer KW - urinary bladder KW - Education KW - body mass KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19607504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Body+size+and+the+risk+of+biliary+tract+cancer%3A+a+population-based+study+in+China&rft.au=Hsing%2C+A+W%3BSakoda%2C+L+C%3BRashid%2C+A%3BChen%2C+J%3BShen%2C+M+C%3BHan%2C+T+Q%3BWang%2C+B+S%3BGao%2C+Y+T&rft.aulast=Hsing&rft.aufirst=A&rft.date=2008-09-02&rft.volume=99&rft.issue=5&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604616 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - China, People's Rep., Shanghai; China, People's Rep.; Cancer; urinary bladder; obesity; Age; cholesterol; Education; body mass; body size DO - http://dx.doi.org/10.1038/sj.bjc.6604616 ER - TY - JOUR T1 - Evaluation of the renal effects of experimental feeding of melamine and cyanuric acid to fish and pigs AN - 745637203; 13097828 AB - Objective--To determine whether renal crystals can be experimentally induced in animals fed melamine or the related triazine compound cyanuric acid, separately or in combination, and to compare experimentally induced crystals with those from a cat with triazine-related renal failure. Animals--75 fish (21 tilapia, 24 rainbow trout, 15 channel catfish, and 15 Atlantic salmon), 4 pigs, and 1 cat that was euthanatized because of renal failure. Procedures--Fish and pigs were fed a target dosage of melamine (400 mg/kg), cyanuric acid (400 mg/kg), or melamine and cyanuric acid (400 mg of each compound/kg) daily for 3 days and were euthanatized 1, 3, 6, 10, or 14 days after administration ceased. Fresh, frozen, and formalin-fixed kidneys were examined for crystals. Edible tissues were collected for residue analysis. Crystals were examined for composition via Raman spectroscopy and hydrophilic-interaction liquid chromatography-tandem mass spectrometry. Results--All animals fed the combination of melamine and cyanuric acid developed goldbrown renal crystals arranged in radial spheres (spherulites), similar to those detected in the cat. Spectral analyses of crystals from the cat, pigs, and fish were consistent with melamine-cyanurate complex crystals. Melamine and cyanuric acid residues were identified in edible tissues of fish. Conclusions and Clinical Relevance--Although melamine and cyanuric acid appeared to have low toxicity when administered separately, they induced extensive renal crystal formation when administered together. The subsequent renal failure may be similar to acute uric acid nephropathy in humans, in which crystal spherulites obstruct renal tubules. JF - American Journal of Veterinary Research AU - Reimschuessel, R AU - Gieseker, C M AU - Miller, R A AU - Ward, J AU - Boehmer, J AU - Rummel, N AU - Heller, D N AU - Nochetto, C AU - de Alwis, GKH AU - Bataller, N AU - Andersen, W C AU - Turnipseed, S B AU - Karbiwnyk, C M AU - Satzger, R D AD - Center for Veterinary Medicine, US FDA, 8401 Muirkirk Rd, Laurel, MD 20708, USA Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1217 EP - 1228 VL - 69 IS - 9 SN - 0002-9645, 0002-9645 KW - Toxicology Abstracts KW - Feeding KW - Renal failure KW - Oncorhynchus mykiss KW - Cyanuric acid KW - To