TY - JOUR T1 - Nonfatal work-related motor vehicle injuries treated in emergency departments in the United States, 1998-2002 AN - 745631542; 12739844 AB - Background Current data on nonfatal work-related motor vehicle injuries are limited and fragmented, often excluding government workers, self-employed workers, and workers on small farms. This study seeks to bridge the present data gap by providing a national profile of nonfatal work-related motor vehicle injuries across all industries and occupations. Methods Study subjects were people who suffered nonfatal work-related motor vehicle injuries and were treated in a hospital emergency department in the United States. Subjects were identified from a stratified probability sample of emergency departments. National estimates and rates were computed. Results From 1998 to 2002, the average annual rate of nonfatal work-related motor vehicle injuries was 7 injuries per 10,000 full-time equivalents. The rate was three times higher in men than in women. The rates were higher in workers 15-19 years of age and in workers 70 years or older. Justice, public order, and safety workers had the largest number of injuries, and taxicab service employees had the highest injury rate of all industries. Truck drivers had the largest number of injuries, and police and detectives, public service employees had the highest injury rate of all occupations. Conclusion Future efforts need to develop and enhance the use of surveillance information at the federal and state level for work-related nonfatal motor vehicle injuries. Prevention efforts need to address occupational motor vehicle safety for both commercial truck/bus drivers and workers who are not commercial drivers but who drive light motor vehicles on the job. Am. J. Ind. Med. 52:698-706, 2009. JF - American Journal of Industrial Medicine AU - Chen, Guang X AD - Analysis and Field Operations Branch, Division of Safety Research, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, gchen@cdc.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 698 EP - 706 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 52 IS - 9 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - USA KW - Age KW - Injuries KW - police KW - Motor vehicles KW - Occupational safety KW - prevention KW - Trucks KW - emergency medical services KW - small farms KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745631542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Nonfatal+work-related+motor+vehicle+injuries+treated+in+emergency+departments+in+the+United+States%2C+1998-2002&rft.au=Chen%2C+Guang+X&rft.aulast=Chen&rft.aufirst=Guang&rft.date=2009-01-01&rft.volume=52&rft.issue=9&rft.spage=698&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20726 L2 - http://www3.interscience.wiley.com/journal/122514405/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; police; Injuries; Motor vehicles; Occupational safety; prevention; Trucks; small farms; emergency medical services; USA DO - http://dx.doi.org/10.1002/ajim.20726 ER - TY - JOUR T1 - Is There Evidence for Synergy Among Air Pollutants in Causing Health Effects? AN - 743484071; 201004-31-0316667 (CE); 12129476 (EN) AB - BACKGROUND: Environmental air pollutants are inhaled as complex mixtures, but the long dominant focus of monitoring and research on individual pollutants has provided modest insight into pollutant interactions that may be important to health. Trends toward managing multiple pollutants to maximize aggregate health gains place increasing value on knowing whether the effects of combinations of pollutants are greater than the sum of the effects of individual pollutants (synergy). OBJECTIVE: We reviewed selected published literature to determine whether synergistic effects of combinations of pollutants on health outcomes have actually been demonstrated. METHODS AND RESULTS: We reviewed 36 laboratory studies of combinations of ozone with other pollutants that were reported in the recent U.S. Environmental Protection Agency Ozone Criteria Document. We examined original reports to determine whether the experimental design tested for synergy and whether synergy was demonstrated. Fourteen studies demonstrated synergism, although synergistic, additive, and antagonistic effects were sometimes observed among different outcomes or at different times after exposure. CONCLUSIONS: Synergisms involving O3 have been demonstrated by laboratory studies of humans and animals. We conclude that the plausibility of synergisms among environmental pollutants has been established, although comparisons are limited, and most involved exposure concentrations much higher than typical of environmental pollutants. Epidemiologic research has limited ability to address the issue explicitly. JF - Environmental Health Perspectives AU - Mauderly, Joe L AU - Samet, Jonathan M PY - 2009 SP - 1 EP - 6 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Pollutants KW - Health KW - Ozone KW - Monitoring KW - Copyrights KW - Gain KW - Human KW - Aggregates KW - Criteria KW - Synergistic effect KW - Epidemiology KW - Trends KW - Additives KW - Animals KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743484071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Is+There+Evidence+for+Synergy+Among+Air+Pollutants+in+Causing+Health+Effects%3F&rft.au=Mauderly%2C+Joe+L%3BSamet%2C+Jonathan+M&rft.aulast=Mauderly&rft.aufirst=Joe&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Retrospective Performance Assessment of the Developmental Neurotoxicity Study in Support of OECD Test Guideline 426 AN - 743431089; 201004-31-0316668 (CE); 12129477 (EN) AB - OBJECTIVE: We conducted a review of the history and performance of developmental neurotoxicity (DNT) testing in support of the finalization and implementation of Organisation of Economic Co-operation and Development (OECD) DNT test guideline 426 (TG 426). INFORMATION SOURCES AND ANALYSIS: In this review we summarize extensive scientific efforts that form the foundation for this testing paradigm, including basic neurotoxicology research, interlaboratory collaborative studies, expert workshops, and validation studies, and we address the relevance, applicability, and use of the DNT study in risk assessment. CONCLUSIONS: The OECD DNT guideline represents the best available science for assessing the potential for DNT in human health risk assessment, and data generated with this protocol are relevant and reliable for the assessment of these end points. The test methods used have been subjected to an extensive history of international validation, peer review, and evaluation, which is contained in the public record. The reproducibility, reliability, and sensitivity of these methods have been demonstrated, using a wide variety of test substances, in accordance with OECD guidance on the validation and international acceptance of new or updated test methods for hazard characterization. Multiple independent, expert scientific peer reviews affirm these conclusions. JF - Environmental Health Perspectives AU - Makris, Susan L AU - Raffaele, Kathleen AU - Allen, Sandra AU - Bowers, Wayne J AU - Hass, Ulla AU - Alleva, Enrico AU - Calamandrei, Gemma AU - Sheets, Larry AU - Amcoff, Patric AU - Delrue, Nathalie AU - Crofton, Kevin M PY - 2009 SP - 17 EP - 25 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Guidelines KW - Health KW - Risk assessment KW - Acceptance tests KW - Copyrights KW - Reproducibility KW - Assessments KW - Economics KW - Human KW - Workshops KW - Foundations KW - Performance assessment KW - Acceptance KW - Cobalt KW - Interlaboratory KW - Information sources KW - Hazards KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743431089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Retrospective+Performance+Assessment+of+the+Developmental+Neurotoxicity+Study+in+Support+of+OECD+Test+Guideline+426&rft.au=Makris%2C+Susan+L%3BRaffaele%2C+Kathleen%3BAllen%2C+Sandra%3BBowers%2C+Wayne+J%3BHass%2C+Ulla%3BAlleva%2C+Enrico%3BCalamandrei%2C+Gemma%3BSheets%2C+Larry%3BAmcoff%2C+Patric%3BDelrue%2C+Nathalie%3BCrofton%2C+Kevin+M&rft.aulast=Makris&rft.aufirst=Susan&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Phthalates Impair Germ Cell Development in the Human Fetal Testis in Vitro without Change in Testosterone Production AN - 743370701; 201004-31-0316669 (CE); 12129478 (EN) AB - BACKGROUND: Several studies have described an increasing frequency of male reproductive disorders, which may have a common origin in fetal life and which are hypothesized to be caused by endocrine disruptors. Phthalate esters represent a class of environmental endocrine-active chemicals known to disrupt development of the male reproductive tract by decreasing testosterone production in the fetal rat. OBJECTIVES: Using the organ culture system we developed previously, we investigated the effects on the development of human fetal testis of one phthalate--mono-2-ethylhexyl phthalate (MEHP)--an industrial chemical found in many products, which has been incriminated as a disruptor of male reproductive function. METHODS: Human fetal testes were recovered during the first trimester (7-12 weeks) of gestation, a critical period for testicular differentiation, and cultured for 3 days with or without MEHP in basal conditions or stimulated with luteinizing hormone (LH). RESULTS: Whatever the dose, MEHP treatment had no effect on basal or LH-stimulated testosterone produced by the human fetal testis in vitro, although testosterone production can be modulated in our culture system. MEHP (10(-4) M) did not affect proliferation or apoptosis of Sertoli cells, but it reduced the mRNA expression of anti-Muellerian hormone. MEHP (10(-4) M) reduced the number of germ cells by increasing their apoptosis, measured by the detection of caspase-3-positive germ cells, without modification of their proliferation. CONCLUSIONS: This is the first experimental demonstration that phthalates alter the development of the germ cell lineage in humans. However, in contrast to results observed in the rat, phthalates did not affect steroidogenesis. JF - Environmental Health Perspectives AU - Lambrot, Romain AU - Muczynski, Vincent AU - Lecureuil, Charlotte AU - Angenard, Gaelle AU - Coffigny, Herve AU - Pairault, Catherine AU - Moison, Delphine AU - Frydman, Rene AU - Habert, Rene AU - Rouiller-Fabre, Virginie PY - 2009 SP - 32 EP - 37 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Human KW - Phthalates KW - Testosterone KW - Males KW - Gestation KW - Apoptosis KW - In vitro testing KW - Culture KW - Hormones KW - Health KW - Reproductive disorders KW - Esters KW - Endocrine disruptors KW - Differentiation KW - Origins KW - Copyrights KW - Testes KW - Organs KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743370701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Phthalates+Impair+Germ+Cell+Development+in+the+Human+Fetal+Testis+in+Vitro+without+Change+in+Testosterone+Production&rft.au=Lambrot%2C+Romain%3BMuczynski%2C+Vincent%3BLecureuil%2C+Charlotte%3BAngenard%2C+Gaelle%3BCoffigny%2C+Herve%3BPairault%2C+Catherine%3BMoison%2C+Delphine%3BFrydman%2C+Rene%3BHabert%2C+Rene%3BRouiller-Fabre%2C+Virginie&rft.aulast=Lambrot&rft.aufirst=Romain&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - One-Month Diesel Exhaust Inhalation Produces Hypertensive Gene Expression Pattern in Healthy Rats AN - 743341414; 201004-31-0316664 (CE); 12129473 (EN) AB - BACKGROUND: Exposure to diesel exhaust (DE) is linked to vasoconstriction, endothelial dysfunction, and myocardial ischemia in compromised individuals. OBJECTIVE: We hypothesized that DE inhalation would cause greater inflammation, hematologic alterations, and cardiac molecular impairment in spontaneously hypertensive (SH) rats than in healthy Wistar Kyoto (WKY) rats. METHODS AND RESULTS: Male rats (12-14 weeks of age) were exposed to air or DE from a 30-kW Deutz engine at 500 or 2,000 microg/m3, 4 hr/day, 5 days/week for 4 weeks. Neutrophilic influx was noted in the lung lavage fluid of both strains, but injury markers were minimally changed. Particle-laden macrophages were apparent histologically in DE-exposed rats. Lower baseline cardiac anti-oxidant enzyme activities were present in SH than in WKY rats; however, no DE effects were noted. Cardiac mitochondrial aconitase activity decreased after DE exposure in both strains. Electron microscopy indicated abnormalities in cardiac mitochondria of control SH but no DE effects. Gene expression profiling demonstrated alterations in 377 genes by DE in WKY but none in SH rats. The direction of DE-induced changes in WKY mimicked expression pattern of control SH rats without DE. Most genes affected by DE were down-regulated in WKY. The same genes were down-regulated in SH without DE producing a hypertensive-like expression pattern. The down-regulated genes included those that regulate compensatory response, matrix metabolism, mitochondrial function, and oxidative stress response. No up-regulation of inflammatory genes was noted. CONCLUSIONS: We provide the evidence that DE inhalation produces a hypertensive-like cardiac gene expression pattern associated with mitochondrial oxidative stress in healthy rats. JF - Environmental Health Perspectives AU - Gottipolu, Reddy R AU - Wallenborn, J Grace AU - Karoly, Edward D AU - Schladweiler, Mette C AU - Ledbetter, Allen D AU - Krantz, Todd AU - Linak, William P AU - Nyska, Abraham AU - Johnson, Jo Anne AU - Thomas, Ronald AU - Richards, Judy E AU - Jaskot, Richard H AU - Kodavanti, Urmila P PY - 2009 SP - 38 EP - 46 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Rats KW - Genes KW - Gene expression KW - Inhalation KW - Diesel KW - Diesel fuels KW - Health KW - Strain KW - Exhaust KW - Alterations KW - Stresses KW - Impairment KW - Vasoconstriction KW - Mitochondria KW - Ischemia KW - Markers KW - Fluid dynamics KW - Fluid flow KW - Macrophages KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743341414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=One-Month+Diesel+Exhaust+Inhalation+Produces+Hypertensive+Gene+Expression+Pattern+in+Healthy+Rats&rft.au=Gottipolu%2C+Reddy+R%3BWallenborn%2C+J+Grace%3BKaroly%2C+Edward+D%3BSchladweiler%2C+Mette+C%3BLedbetter%2C+Allen+D%3BKrantz%2C+Todd%3BLinak%2C+William+P%3BNyska%2C+Abraham%3BJohnson%2C+Jo+Anne%3BThomas%2C+Ronald%3BRichards%2C+Judy+E%3BJaskot%2C+Richard+H%3BKodavanti%2C+Urmila+P&rft.aulast=Gottipolu&rft.aufirst=Reddy&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Effect of Calcium Supplementation on Blood Lead Levels in Pregnancy: A Randomized Placebo-Controlled Trial AN - 743196235; 201004-31-0316666 (CE); 12129475 (EN) AB - BACKGROUND: Prenatal lead exposure is associated with deficits in fetal growth and neurodevelopment. Calcium supplementation may attenuate fetal exposure by inhibiting mobilization of maternal bone lead and/or intestinal absorption of ingested lead. OBJECTIVE: Our goal was to evaluate the effect of 1,200 mg dietary calcium supplementation on maternal blood lead levels during pregnancy. METHODS: In a double-blind, randomized, placebo-controlled trial conducted from 2001 through 2003 in Mexico City, we randomly assigned 670 women in their first trimester of pregnancy to ingest calcium (n = 334) or placebo (n = 336). We followed subjects through pregnancy and evaluated the effect of supplementation on maternal blood lead, using an intent-to-treat analysis by a mixed-effects regression model with random intercept, in 557 participants (83%) who completed follow-up. We then conducted as-treated analyses using similar models stratified by treatment compliance. RESULTS: Adjusting for baseline lead level, age, trimester of pregnancy, and dietary energy and calcium intake, calcium was associated with an average 11% reduction (0.4 microg/dL) in blood lead level relative to placebo (p = 0.004). This reduction was more evident in the second trimester (-14%, p 0.001) than in the third (-8%, p = 0.107) and was strongest in women who were most compliant (those who consumed or = 75% calcium pills; -24%, p 0.001), had baseline blood lead 5 microg/dL (-17%, p 0.01), or reported use of lead-glazed ceramics and high bone lead (-31%, p 0.01). CONCLUSION: Calcium supplementation was associated with modest reductions in blood lead when administered during pregnancy and may constitute an important secondary prevention effort to reduce circulating maternal lead and, consequently, fetal exposure. JF - Environmental Health Perspectives AU - Ettinger, Adrienne S AU - Lamadrid-Figueroa, Hector AU - Tellez-Rojo, Martha M AU - Mercado-Garcia, Adriana AU - Peterson, Karen E AU - Schwartz, Joel AU - Hu, Howard AU - Hernandez-Avila, Mauricio PY - 2009 SP - 26 EP - 31 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Calcium KW - Blood KW - Pregnancy KW - Reduction KW - Bones KW - Regression analysis KW - Health KW - Intakes KW - Attenuation KW - Circulating KW - Regression KW - Ceramics KW - Copyrights KW - Consumption KW - Pills KW - Mathematical models KW - Age KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743196235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Effect+of+Calcium+Supplementation+on+Blood+Lead+Levels+in+Pregnancy%3A+A+Randomized+Placebo-Controlled+Trial&rft.au=Ettinger%2C+Adrienne+S%3BLamadrid-Figueroa%2C+Hector%3BTellez-Rojo%2C+Martha+M%3BMercado-Garcia%2C+Adriana%3BPeterson%2C+Karen+E%3BSchwartz%2C+Joel%3BHu%2C+Howard%3BHernandez-Avila%2C+Mauricio&rft.aulast=Ettinger&rft.aufirst=Adrienne&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Prenatal Exposure to Polychlorinated Biphenyls: A Neuropsychologic Analysis AN - 743073127; 201004-31-0316665 (CE); 12129474 (EN) AB - OBJECTIVES: A large body of literature documents the effects of prenatal exposure to polychlorinated biphenyls (PCBs) on cognitive development of children. Despite this fact, no integrative synthesis has been published yet to identify the cognitive functions that are particularly affected. Our aim is to review this literature in an attempt to identify the cognitive profile associated with prenatal PCB exposure. DATA SOURCES: Studies were identified by searching the PubMed database for articles published before June 2008. We reviewed data from nine prospective longitudinal birth cohorts for different aspects of cognition. DATA EXTRACTION: Associations between indicators of prenatal PCB exposure and performance on cognitive tasks reported in the selected studies are summarized and classified as general cognitive abilities, verbal or visual-spatial skills, memory, attention, and executive functions. DATA SYNTHESIS: The most consistent effects observed across studies are impaired executive functioning related to increased prenatal PCB exposure. Negative effects on processing speed, verbal abilities, and visual recognition memory are also reported by most studies. Converging results from different cohort studies in which exposure arises from different sources make it unlikely that co-exposure with another associated contaminant is responsible for the observed effects. CONCLUSION: Prenatal PCB exposure appears to be related to a relatively specific cognitive profile of impairments. Failure to assess functions that are specifically impaired may explain the absence of effects found in some studies. Our findings have implications in the selection of cognitive assessment methods in future studies. JF - Environmental Health Perspectives AU - Boucher, Olivier AU - Muckle, Gina AU - Bastien, Celyne H PY - 2009 SP - 7 EP - 16 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Circuit boards KW - Printed circuits KW - Health KW - Synthesis KW - Polychlorinated biphenyls KW - Databases KW - Searching KW - Cognitive tasks KW - Assessments KW - Failure KW - Cognition KW - Impairment KW - Extraction KW - Contaminants KW - Children KW - Data sources KW - Recognition KW - Indicators KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743073127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prenatal+Exposure+to+Polychlorinated+Biphenyls%3A+A+Neuropsychologic+Analysis&rft.au=Boucher%2C+Olivier%3BMuckle%2C+Gina%3BBastien%2C+Celyne+H&rft.aulast=Boucher&rft.aufirst=Olivier&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Gene by environment interaction in asthma. AN - 67595808; 18980546 AB - Marked international differences in rates of asthma and allergies and the importance of family history highlight the primacy of interactions between genetic variation and the environment in asthma etiology. Environmental tobacco smoke (or secondhand smoke), ambient air pollutants, and endotoxin and/or other pathogen-associated molecular patterns are the ambient exposures studied most frequently for interactions with genetic polymorphisms in asthma. To date, results from the literature remain inconclusive. Most published studies are underpowered to study interactions between genetic polymorphisms and ambient exposures, each with weak effects. Strategies to increase power include cooperation across studies to increase sample sizes and improve measures of both exposure and asthma phenotypes. Genome-wide association studies hold promise for identifying unexpected gene environment interactions, but given the statistical power issues, candidate gene association studies will remain important. New tools are enabling the study of epigenetic mechanisms for environmental interactions. JF - Annual review of public health AU - London, Stephanie J AU - Romieu, Isabelle AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. london2@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 55 EP - 80 VL - 30 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Respiratory Function Tests KW - Genotype KW - Risk Factors KW - Humans KW - Methylation KW - Asthma -- epidemiology KW - Polymorphism, Genetic KW - Asthma -- blood KW - Asthma -- genetics KW - Tobacco Smoke Pollution -- adverse effects KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67595808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+public+health&rft.atitle=Gene+by+environment+interaction+in+asthma.&rft.au=London%2C+Stephanie+J%3BRomieu%2C+Isabelle&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2009-01-01&rft.volume=30&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+public+health&rft.issn=1545-2093&rft_id=info:doi/10.1146%2Fannurev.publhealth.031308.100151 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-08 N1 - Date created - 2009-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1146/annurev.publhealth.031308.100151 ER - TY - JOUR T1 - Effects of cooperating and conflicting cues on speech intonation recognition by cochlear implant users and normal hearing listeners. AN - 67488152; 19372651 AB - Cochlear implant (CI) recipients have only limited access to fundamental frequency (F0) information, and thus exhibit deficits in speech intonation recognition. For speech intonation, F0 serves as the primary cue, and other potential acoustic cues (e.g. intensity properties) may also contribute. This study examined the effects of cooperating or conflicting acoustic cues on speech intonation recognition by adult CI and normal hearing (NH) listeners with full-spectrum and spectrally degraded speech stimuli. Identification of speech intonation that signifies question and statement contrasts was measured in 13 CI recipients and 4 NH listeners, using resynthesized bi-syllabic words, where F0 and intensity properties were systematically manipulated. The stimulus set was comprised of tokens whose acoustic cues (i.e. F0 contour and intensity patterns) were either cooperating or conflicting. Subjects identified if each stimulus is a 'statement' or a 'question' in a single-interval, 2-alternative forced-choice (2AFC) paradigm. Logistic models were fitted to the data, and estimated coefficients were compared under cooperating and conflicting conditions, between the subject groups (CI vs. NH), and under full-spectrum and spectrally degraded conditions for NH listeners. The results indicated that CI listeners' intonation recognition was enhanced by cooperating F0 contour and intensity cues, but was adversely affected by these cues being conflicting. On the other hand, with full-spectrum stimuli, NH listeners' intonation recognition was not affected by cues being cooperating or conflicting. The effects of cues being cooperating or conflicting were comparable between the CI group and NH listeners with spectrally degraded stimuli. These findings suggest the importance of taking multiple acoustic sources for speech recognition into consideration in aural rehabilitation for CI recipients. Copyright (C) 2009 S. Karger AG, Basel. JF - Audiology & neuro-otology AU - Peng, Shu-Chen AU - Lu, Nelson AU - Chatterjee, Monita AD - Center for Device and Radiological Health, US Food and Drug Administration, Rockville, MD, USA. speng@hesp.umd.edu Y1 - 2009 PY - 2009 DA - 2009 SP - 327 EP - 337 VL - 14 IS - 5 KW - Index Medicus KW - Young Adult KW - Logistic Models KW - Aged, 80 and over KW - Humans KW - Adult KW - Noise KW - Aged KW - Speech Reception Threshold Test KW - Middle Aged KW - Acoustic Stimulation KW - Psychometrics KW - Male KW - Female KW - Speech Perception KW - Hearing Loss -- rehabilitation KW - Hearing Loss -- physiopathology KW - Phonetics KW - Hearing KW - Cochlear Implants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67488152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Audiology+%26+neuro-otology&rft.atitle=Effects+of+cooperating+and+conflicting+cues+on+speech+intonation+recognition+by+cochlear+implant+users+and+normal+hearing+listeners.&rft.au=Peng%2C+Shu-Chen%3BLu%2C+Nelson%3BChatterjee%2C+Monita&rft.aulast=Peng&rft.aufirst=Shu-Chen&rft.date=2009-01-01&rft.volume=14&rft.issue=5&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Audiology+%26+neuro-otology&rft.issn=1421-9700&rft_id=info:doi/10.1159%2F000212112 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-08 N1 - Date created - 2009-07-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Acoust Soc Am. 2000 Oct;108(4):1877-87 [11051514] Ear Hear. 2008 Jun;29(3):336-51 [18344873] J Acoust Soc Am. 2001 Aug;110(2):1150-63 [11519582] J Acoust Soc Am. 2002 May;111(5 Pt 1):2250-6 [12051445] J Acoust Soc Am. 2002 Nov;112(5 Pt 1):2155-64 [12430827] Ear Hear. 2004 Jun;25(3):251-64 [15179116] J Exp Child Psychol. 1984 Apr;37(2):231-50 [6726113] J Speech Hear Res. 1989 Jun;32(2):307-16 [2739382] J Acoust Soc Am. 1990 Jun;87(6):2592-605 [2373794] Percept Psychophys. 1991 Feb;49(2):187-200 [2017355] Phonetica. 1992;49(1):25-47 [1603839] Philos Trans R Soc Lond B Biol Sci. 1992 Jun 29;336(1278):367-73 [1354376] Science. 1995 Oct 13;270(5234):303-4 [7569981] J Acoust Soc Am. 1999 Mar;105(3):1889-900 [10089611] J Acoust Soc Am. 2004 Oct;116(4 Pt 1):2298-310 [15532661] J Assoc Res Otolaryngol. 2005 Mar;6(1):19-27 [15735937] J Acoust Soc Am. 2001 Feb;109(2):713-26 [11248975] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1159/000212112 ER - TY - JOUR T1 - EEG and cerebral blood flow velocity abnormalities in chronic cocaine users. AN - 67016958; 19278131 AB - EEG and cerebral blood flow abnormalities have been documented in chronic cocaine abusers. To identify possible relationships between EEG and blood flow changes and their relationship to the intensity of cocaine use, we recorded the resting eyes-closed EEG and anterior (ACA) and middle (MCA) cerebral artery blood flow velocity during systole (V(S)) and diastole (V(D)) by transcranial Doppler (TCD) sonography of 99 (76 male, 23 female; mean [SD] age 34.3 [5.2] years, 8.6 [5.5] years of cocaine use, 17.8 [7.7] days of cocaine use in month prior to screening) cocaine users within 5 days of admission to a closed research unit. Forty-two non-drug-using, age-matched control subjects (22 male, 20 female) were tested as outpatients. A 3-minute period of resting EEG was recorded from 16 standard scalp electrodes. Artifact-free EEG was converted to six frequency bands (delta, theta, alpha1, alpha2, beta1 and beta2) using a Fast Fourier Transform. Pulsatility index (PI) was calculated as a measure of small vessel resistance. Cocaine users had decreased VD and increased PI in the MCA, with no difference in V(S), and reduced EEG theta, beta1 and beta2 absolute power in posterior brain regions. Recent cocaine use was positively associated with MCA PI (r = 0.27, p < 0.001) and negatively associated with low frequency EEG power (delta power: r = -0.25, p < 0.002; theta power: r = -0.29, p < 0.001). EEG beta1 (r = -0.211, p < 0.05) and beta2 (r = -0.176, p < 0.05) power measures were correlated with PI. These observations suggest that EEG and TCD changes reflect related physiological processes during early cocaine abstinence. JF - Clinical EEG and neuroscience AU - Copersino, Marc L AU - Herning, Ronald I AU - Better, Warren AU - Cadet, Jean-Lud AU - Gorelick, David A AD - Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 39 EP - 42 VL - 40 IS - 1 SN - 1550-0594, 1550-0594 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Analysis of Variance KW - Blood Flow Velocity KW - Humans KW - Adult KW - Ultrasonography, Doppler, Transcranial KW - Cocaine -- toxicity KW - Fourier Analysis KW - Male KW - Female KW - Anterior Cerebral Artery -- drug effects KW - Brain -- blood supply KW - Brain -- drug effects KW - Electroencephalography KW - Anterior Cerebral Artery -- diagnostic imaging KW - Cerebrovascular Circulation KW - Middle Cerebral Artery -- diagnostic imaging KW - Cocaine-Related Disorders -- diagnostic imaging KW - Brain -- physiopathology KW - Middle Cerebral Artery -- physiopathology KW - Middle Cerebral Artery -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Anterior Cerebral Artery -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67016958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+EEG+and+neuroscience&rft.atitle=EEG+and+cerebral+blood+flow+velocity+abnormalities+in+chronic+cocaine+users.&rft.au=Copersino%2C+Marc+L%3BHerning%2C+Ronald+I%3BBetter%2C+Warren%3BCadet%2C+Jean-Lud%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2009-01-01&rft.volume=40&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Clinical+EEG+and+neuroscience&rft.issn=15500594&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-03 N1 - Date created - 2009-03-12 N1 - Date revised - 2017-02-15 N1 - SuppNotes - Cited By: Addict Behav. 1994 Nov-Dec;19(6):599-607 [7701971] J Nucl Med. 1995 Jul;36(7):1211-5 [7790946] J Neurosurg. 1996 Jan;84(1):79-84 [8613840] Psychiatry Res. 1995 Oct 16;58(3):247-57 [8570780] Epilepsia. 1996 Sep;37(9):875-8 [8814101] Biol Psychiatry. 1996 Nov 15;40(10):986-93 [8915557] Neurology. 1997 Feb;48(2):341-5 [9040718] Biol Psychiatry. 1997 Jun 1;41(11):1087-94 [9146819] Drug Alcohol Depend. 1997 Jun 6;46(1-2):87-93 [9246556] Neuropsychopharmacology. 1998 Jul;19(1):1-9 [9608571] Biol Psychiatry. 1999 May 1;45(9):1203-11 [10331113] J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):209-21 [10333992] Neuropsychopharmacology. 1999 Jul;21(1):110-8 [10379525] J Clin Neurophysiol. 2004 Sep-Oct;21(5):341-52 [15592008] Arch Gen Psychiatry. 2007 Apr;64(4):495-502 [17404126] Postgrad Med J. 2007 Jun;83(980):389-94 [17551070] Clin Neurophysiol. 2000 Apr;111(4):604-12 [10727911] Stroke. 2000 May;31(5):1111-5 [10797173] Neuropsychobiology. 2000;42(2):93-8 [10940764] Clin Neurophysiol. 2000 Nov;111(11):1961-7 [11068230] Neuropsychopharmacology. 2001 Sep;25(3):332-40 [11522462] Stroke. 2001 Oct;32(10):2338-43 [11588323] Epilepsia. 2002;43 Suppl 2:28-31 [11903480] Biol Psychiatry. 2002 Oct 15;52(8):831-42 [12372655] J Psychoactive Drugs. 2002 Oct-Dec;34(4):415-9 [12562110] Stroke. 2003 Jun;34(6):1375-81 [12764233] Radiology. 1990 Sep;176(3):821-4 [2389042] Am J Drug Alcohol Abuse. 1990;16(3-4):307-17 [2126913] Headache. 1991 Jan;31(1):17-9 [2016163] J Nucl Med. 1991 Jun;32(6):1206-10 [2045934] Psychiatry Res. 1990 Dec;35(2):95-105 [2100807] J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):803-6 [1955899] J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):419-27 [8286941] J Nucl Med. 1994 Dec;35(12):1902-9 [7989967] Neuropsychobiology. 1994;30(4):189-96 [7862268] N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Hyperthermia increases the cytotoxicity of many exogenous compounds. AN - 66914669; 19215178 AB - Cytotoxicity testing of extracts from medical device materials is typically conducted at 37 degrees C. It may be more relevant to screen extracts from device materials for in vitro cytotoxicity at temperatures found in febrile patients. To address this, the cytotoxicity of selected chemicals, drugs, and medical device extracts was evaluated in vitro following incubation at normothermic (37 degrees C) and hyperthermic (39 degrees C) conditions. In L929 cells, the percentage of cell death increased from 2-fold to more than 4-fold after chemical exposure when cells were maintained at 39 degrees C. Extracts of some medical devices and materials showed a 10-fold increase in cytotoxicity when cells were maintained at 39 degrees C as compared to 37 degrees C. For many of the substances in this study, exogenous compounds that are toxic at normothermic conditions (37 degrees C) are more cytotoxic under hyperthermic conditions (39 degrees C). The toxicity of compounds was more readily discernable at the higher incubation temperature, even at lower concentrations. In vitro cytotoxicity testing of chemicals and extracts at febrile temperatures can provide more sensitive and relevant biocompatibility tests than under normothermic conditions alone. JF - Biomedical instrumentation & technology AU - Lucas, Anne D AU - Lappalainen, Sharon K AU - Wray-Cahen, Diane AD - US Food and Drug Administration, Center for Device and Radiological Health, Silver Spring, MD 20903, USA. anne.lucas@fda.hhs.gov PY - 2009 SP - 73 EP - 79 VL - 43 IS - 1 SN - 0899-8205, 0899-8205 KW - Metals KW - 0 KW - Organic Chemicals KW - Pharmaceutical Preparations KW - Index Medicus KW - Animals KW - Humans KW - Jurkat Cells KW - Mice KW - Cell Line KW - Pharmaceutical Preparations -- administration & dosage KW - Hot Temperature KW - Fibroblasts -- drug effects KW - Metals -- administration & dosage KW - Organic Chemicals -- administration & dosage KW - Apoptosis -- drug effects KW - Fibroblasts -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66914669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+instrumentation+%26+technology&rft.atitle=Hyperthermia+increases+the+cytotoxicity+of+many+exogenous+compounds.&rft.au=Lucas%2C+Anne+D%3BLappalainen%2C+Sharon+K%3BWray-Cahen%2C+Diane&rft.aulast=Lucas&rft.aufirst=Anne&rft.date=2009-01-01&rft.volume=43&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Biomedical+instrumentation+%26+technology&rft.issn=08998205&rft_id=info:doi/10.2345%2F0899-8205-43.1.73 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-19 N1 - Date created - 2009-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2345/0899-8205-43.1.73 ER - TY - JOUR T1 - Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. AN - 66852343; 18978339 AB - Benzene is an established human hematotoxicant and leukemogen but its mechanism of action is unclear. To investigate the role of single-nucleotide polymorphisms (SNPs) on benzene-induced hematotoxicity, we analyzed 1395 SNPs in 411 genes using an Illumina GoldenGate assay in 250 benzene-exposed workers and 140 unexposed controls. Highly significant findings clustered in five genes (BLM, TP53, RAD51, WDR79 and WRN) that play a critical role in DNA repair and genomic maintenance, and these regions were then further investigated with tagSNPs. One or more SNPs in each gene were associated with highly significant 10-20% reductions (P values ranged from 0.0011 to 0.0002) in the white blood cell (WBC) count among benzene-exposed workers but not controls, with evidence for gene-environment interactions for SNPs in BLM, WRN and RAD51. Further, among workers exposed to benzene, the genotype-associated risk of having a WBC count 8-fold. In vitro functional studies revealed that deletion of SGS1 in yeast, equivalent to lacking BLM and WRN function in humans, caused reduced cellular growth in the presence of the toxic benzene metabolite hydroquinone, and knockdown of WRN using specific short hairpin RNA increased susceptibility of human TK6 cells to hydroquinone toxicity. Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity. JF - Carcinogenesis AU - Lan, Qing AU - Zhang, Luoping AU - Shen, Min AU - Jo, William J AU - Vermeulen, Roel AU - Li, Guilan AU - Vulpe, Christopher AU - Lim, Sophia AU - Ren, Xuefeng AU - Rappaport, Stephen M AU - Berndt, Sonja I AU - Yeager, Meredith AU - Yuenger, Jeff AU - Hayes, Richard B AU - Linet, Martha AU - Yin, Songnian AU - Chanock, Stephen AU - Smith, Martyn T AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. qingl@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 50 EP - 58 VL - 30 IS - 1 KW - Benzene KW - J64922108F KW - Index Medicus KW - Occupational Exposure KW - Polymorphism, Single Nucleotide KW - Humans KW - DNA Repair KW - Benzene -- toxicity KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66852343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Large-scale+evaluation+of+candidate+genes+identifies+associations+between+DNA+repair+and+genomic+maintenance+and+development+of+benzene+hematotoxicity.&rft.au=Lan%2C+Qing%3BZhang%2C+Luoping%3BShen%2C+Min%3BJo%2C+William+J%3BVermeulen%2C+Roel%3BLi%2C+Guilan%3BVulpe%2C+Christopher%3BLim%2C+Sophia%3BRen%2C+Xuefeng%3BRappaport%2C+Stephen+M%3BBerndt%2C+Sonja+I%3BYeager%2C+Meredith%3BYuenger%2C+Jeff%3BHayes%2C+Richard+B%3BLinet%2C+Martha%3BYin%2C+Songnian%3BChanock%2C+Stephen%3BSmith%2C+Martyn+T%3BRothman%2C+Nathaniel&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2009-01-01&rft.volume=30&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn249 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Biometrics. 1986 Mar;42(1):121-30 [3719049] Science. 2002 Jun 21;296(5576):2225-9 [12029063] J Biol Chem. 2002 Aug 30;277(35):31980-7 [12080066] Am J Ind Med. 2002 Oct;42(4):275-85 [12271475] Nat Rev Cancer. 2003 Mar;3(3):169-78 [12612652] Environ Health Perspect. 2003 Aug;111(11):1411-20 [12928149] Cancer Res. 2003 Nov 15;63(22):7657-62 [14633686] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003 Apr;21(2):86-9 [14761515] Br J Ind Med. 1987 Feb;44(2):124-8 [3814544] Cancer Res. 1990 Jun 1;50(11):3141-5 [2110504] Cancer Res. 1991 Nov 15;51(22):6094-7 [1933872] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Carcinogenesis. 1995 Nov;16(11):2841-6 [7586207] Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6236-40 [8692798] Am J Ind Med. 1996 Mar;29(3):236-46 [8833776] Eur J Haematol Suppl. 1996;60:111-8 [8987252] Environ Health Perspect. 1996 Dec;104 Suppl 6:1247-50 [9118900] Cancer Res. 1997 Jul 15;57(14):2839-42 [9230185] EMBO J. 1998 Jan 15;17(2):598-608 [9430650] Cancer Res. 1998 May 15;58(10):2176-81 [9605763] Carcinogenesis. 1998 Jun;19(6):973-8 [9667733] Mutat Res. 1998 Jul 17;403(1-2):65-73 [9726007] Genes Dev. 1999 Jun 1;13(11):1355-60 [10364153] J Biol Chem. 1999 Oct 8;274(41):29463-9 [10506209] Science. 2004 Dec 3;306(5702):1774-6 [15576619] Cancer Res. 2005 Oct 15;65(20):9152-4 [16230371] Cancer Res. 2005 Oct 15;65(20):9574-81 [16230423] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Carcinogenesis. 2006 Oct;27(10):2083-9 [16728435] Blood. 2006 Dec 1;108(12):3916-8 [16902145] J Med Genet. 2007 Jan;44(1):e61 [17209131] Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):270-5 [17301259] Adv Genet. 2007;58:67-87 [17452246] Genet Epidemiol. 2007 Sep;31(6):553-64 [17487883] Am J Hum Genet. 2007 Dec;81(6):1186-200 [17999359] Mutat Res. 2008 Jan 8;649(1-2):54-61 [17875398] Leuk Res. 2007 Feb;31(2):169-74 [16890287] Ann Occup Hyg. 2004 Mar;48(2):105-16 [14990432] Genes Chromosomes Cancer. 2004 Oct;41(2):109-16 [15287023] Stem Cells. 2004;22(5):750-8 [15342939] Trends Genet. 2000 Jun;16(6):259-64 [10827453] J Toxicol Environ Health A. 2000 Nov;61(5-6):357-72 [11086940] Biochemistry. 2000 Nov 28;39(47):14617-25 [11087418] Nat Genet. 2001 Jan;27(1):113-6 [11138010] Am J Ind Med. 2001 Aug;40(2):117-26 [11494338] Blood. 1978 Aug;52(2):285-92 [667356] Oncogene. 2002 Jun 6;21(25):4065-9 [12037689] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn249 ER - TY - JOUR T1 - Occupational factors and risk of preterm birth in nurses. AN - 66782029; 18976732 AB - We evaluated first-trimester exposures and the risk of preterm birth in the most recent pregnancy of participants of the Nurses' Health Study II. Log binomial regression was used to estimate the relative risk (RR) for preterm birth in relation to occupational risk factors, such as work schedule, physical factors, and exposures to chemicals and x-rays, adjusted for age and parity. Part-time work (2 years) infected in The Netherlands. Of all TB cases during the 12-year study period, 38% were infected in a foreign country, 36% resulted from recent transmission in The Netherlands, and 18% resulted from remote infection in The Netherlands, while in the remaining cases (9%) either the time or place of infection could not be determined. The conventional epidemiological data suggested that at least 29% of clustered cases were not part of recent chains of transmission. Cases with unknown fingerprints, almost all culture negative, relatively frequently had confirmed epidemiological links with a recent pulmonary TB case in The Netherlands and were more often identified by contact tracing. Our findings highlight the idea that genotyping should be combined with conventional epidemiological investigation to establish the place and time of infection of TB cases as accurately as possible. A standardized way of classifying TB into recently, remotely, and foreign-acquired disease provides indicators for surveillance and TB control program performance that can be used to decide on interventions and allocation of resources. JF - Journal of Clinical Microbiology AU - Vries, Gde AU - M Baars, HW AU - G. G. Sebek, MM AU - H van Hest, NA AU - Richardus, J H AD - Department of Tuberculosis Control, Municipal Public Health Service Rotterdam-Rijnmond, P.O. Box 70032, 3000 LP Rotterdam, The Netherlands, devriesg@ggd.rotterdam.nl Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 3924 EP - 3930 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 46 IS - 12 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - Mycobacterium KW - Genotyping KW - Control programs KW - Population studies KW - Infection KW - Contact tracing KW - Models KW - Classification KW - Lung KW - DNA KW - Tuberculosis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839684867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Transmission+Classification+Model+To+Determine+Place+and+Time+of+Infection+of+Tuberculosis+Cases+in+an+Urban+Area+%2C&rft.au=Vries%2C+Gde%3BM+Baars%2C+HW%3BG.+G.+Sebek%2C+MM%3BH+van+Hest%2C+NA%3BRichardus%2C+J+H&rft.aulast=Vries&rft.aufirst=Gde&rft.date=2008-12-01&rft.volume=46&rft.issue=12&rft.spage=3924&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00793-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Number of references - 37 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Data processing; Classification; Lung; Control programs; Genotyping; DNA; Population studies; Tuberculosis; Contact tracing; Infection; Models; Mycobacterium DO - http://dx.doi.org/10.1128/JCM.00793-08 ER - TY - JOUR T1 - Introduction to the Special Section: The Application of Effect Sizes in Research on Children and Families AN - 839580544; 201104097 AB - Effect sizes are increasingly used to describe the magnitude of findings about program effectiveness across a range of policy contexts. However, often, both researchers and policy makers could benefit from more information about the factors that affect the calculation and interpretation of these effect sizes. To address these issues, the Administration for Children and Families and federal partners convened a roundtable in 2007, entitled Application of Effect Sizes in Research on Children and Families. This special section includes articles from this roundtable that begin a focused discussion about the purposes, calculation, and interpretation of effect sizes. Adapted from the source document. JF - Child Development Perspectives AU - Supplee, Lauren H Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 164 EP - 166 PB - Wiley Publishing, Malden, MA 02148 VL - 2 IS - 3 SN - 1750-8592, 1750-8592 KW - effect sizes KW - methods KW - evidence-based practice KW - Policy makers KW - Magnitude KW - Evaluative research KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839580544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development+Perspectives&rft.atitle=Introduction+to+the+Special+Section%3A+The+Application+of+Effect+Sizes+in+Research+on+Children+and+Families&rft.au=Supplee%2C+Lauren+H&rft.aulast=Supplee&rft.aufirst=Lauren&rft.date=2008-12-01&rft.volume=2&rft.issue=3&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Child+Development+Perspectives&rft.issn=17508592&rft_id=info:doi/10.1111%2Fj.1750-8606.2008.00059.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Children; Policy makers; Magnitude; Evaluative research DO - http://dx.doi.org/10.1111/j.1750-8606.2008.00059.x ER - TY - JOUR T1 - Measuring Hospital Inefficiency: The Effects of Controlling for Quality and Patient Burden of Illness AN - 839575008; 201103046 AB - Objective: To assess the impact of employing a variety of controls for hospital quality and patient burden of illness on the mean estimated inefficiency and relative ranking of hospitals generated by stochastic frontier analysis (SFA). Study Setting: This study included urban U.S. hospitals in 20 states operating in 2001. Data Design/Data Collection: We took hospital data for 1,290 hospitals from the American Hospital Association Annual Survey and the Medicare Cost Reports. We employed a variety of controls for hospital quality and patient burden of illness. Among the variables we used were a subset of the quality indicators generated from the application of the Patient Safety Indicator and Inpatient Quality Indicator modules of the Agency for Healthcare Research and Quality, Quality Indicator software to the Healthcare Cost and Utilization Project (HCUP), State Inpatient Databases. Measures of a component of patient burden of illness came from the application of the Comorbidity Software to HCUP data. Data Analysis: We used SFA to estimate hospital cost-inefficiency. We tested key assumptions of the SFA model with likelihood ratio tests. Principal Findings: The measures produced by the Comorbidity Software appear to account for variations in patient burden of illness that had previously been masquerading as inefficiency. Outcome measures of quality can provide useful insight into a hospital's operations but may have little impact on estimated inefficiency once controls for structural quality and patient burden of illness have been employed. Conclusions: Choices about controlling for quality and patient burden of illness can have a nontrivial impact on mean estimated hospital inefficiency and the relative ranking of hospitals generated by SFA. Adapted from the source document. JF - Health Services Research AU - Mutter, Ryan L AU - Rosko, Michael D AU - Wong, Herbert S AD - Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, Rockville, MD Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1992 EP - 2013 PB - Blackwell Publishers, Oxford UK VL - 43 IS - 6 SN - 0017-9124, 0017-9124 KW - Hospital efficiency stochastic frontier analysis hospital quality patient safety KW - Quality of care KW - Hospitalization KW - Comorbidity KW - Quality management KW - Burden KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839575008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=Highly+Variable+Drugs%3A+Observations+from+Bioequivalence+Data+Submitted+to+the+FDA+for+New+Generic+Drug+Applications&rft.au=Davit%2C+Barbara+M%3BConner%2C+Dale+P%3BFabian-Fritsch%2C+Beth%3BHaidar%2C+Sam+H%3BJiang%2C+Xiaojian%3BPatel%2C+Devvrat+T%3BSeo%2C+Paul+R+H%3BSuh%2C+Keri%3BThompson%2C+Christina+L%3BYu%2C+Lawrence+X&rft.aulast=Davit&rft.aufirst=Barbara&rft.date=2008-03-01&rft.volume=10&rft.issue=1&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Fs12248-008-9015-x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Hospitals; Burden; Quality management; Comorbidity; Quality of care; Hospitalization DO - http://dx.doi.org/10.1111/j.1475-6773.2008.00892.x ER - TY - JOUR T1 - The Impact of Medical Errors on Ninety-Day Costs and Outcomes: An Examination of Surgical Patients AN - 839571168; 201101163 AB - Objective: To estimate the effect of medical errors on medical expenditures, death, readmissions, and outpatient care within 90 days after surgery. Data Sources: 2001-2002 MarketScan insurance claims for 5.6 million enrollees. Study Design: The Agency for Healthcare Research and Quality Patient Safety Indicators (PSIs) were used to identify 14 PSIs among 161,004 surgeries. We used propensity score matching and multivariate regression analyses to predict expenditures and outcomes attributable to the 14 PSIs. Principal Findings: Excess 90-day expenditures likely attributable to PSIs ranged from $646 for technical problems (accidental laceration, pneumothorax, etc.) to $28,218 for acute respiratory failure, with up to 20 percent of these costs incurred postdischarge. With a third of all 90-day deaths occurring postdischarge, the excess death rate associated with PSIs ranged from 0 to 7 percent. The excess 90-day readmission rate associated with PSIs ranged from 0 to 8 percent. Overall, 11 percent of all deaths, 2 percent of readmissions, and 2 percent of expenditures were likely due to these 14 PSIs. Conclusions: The effects of medical errors continue long after the patient leaves the hospital. Medical error studies that focus only on the inpatient stay can underestimate the impact of patient safety events by up to 20-30 percent. Adapted from the source document. JF - Health Services Research AU - Encinosa, William E AU - Hellinger, Fred J AD - Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2067 EP - 2085 PB - Blackwell Publishers, Oxford UK VL - 43 IS - 6 SN - 0017-9124, 0017-9124 KW - Medical errors patient safety expenditures KW - Critical incidents KW - Death KW - Expenditure KW - Readmission KW - Surgery KW - Patient care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839571168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=The+Impact+of+Medical+Errors+on+Ninety-Day+Costs+and+Outcomes%3A+An+Examination+of+Surgical+Patients&rft.au=Encinosa%2C+William+E%3BHellinger%2C+Fred+J&rft.aulast=Encinosa&rft.aufirst=William&rft.date=2008-12-01&rft.volume=43&rft.issue=6&rft.spage=2067&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2008.00882.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Expenditure; Critical incidents; Death; Readmission; Patient care; Surgery DO - http://dx.doi.org/10.1111/j.1475-6773.2008.00882.x ER - TY - JOUR T1 - Ultrasonic attenuation in parallel-nylon-wire cancellous-bone-mimicking phantoms. AN - 742776754; pmid-19206826 AB - Attenuation coefficients between 1.5 and 3.5 MHz were measured on four parallel-nylon-wire arrays (simulating cancellous bone) with four different wire diameters (150, 200, 250, and 300 microm). Interwire spacing was 800 microm for all four parallel-nylon-wire arrays. The measured frequency dependencies of attenuation were consistent with theoretical predications based on Faran's theory, which considers the component of attenuation due to scattering of longitudinal waves. JF - The Journal of the Acoustical Society of America AU - Wear, Keith A AD - US Food and Drug Administration, Silver Spring, Maryland 20993, USA. keith.wear@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 4042 EP - 4046 VL - 124 IS - 6 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Models, Theoretical KW - Phantoms, Imaging KW - Ultrasonography -- instrumentation KW - Nylons KW - Bone and Bones -- ultrasonography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742776754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Performance+evaluation+of+cytometric+bead+assays+for+the+measurement+of+lung+cytokines+in+two+rodent+models&rft.au=Young%2C+SH%3BAntonini%2C+J+M%3BRoberts%2C+J+R%3BErdely%2C+AD%3BZeidler-Erdely%2C+P+C&rft.aulast=Young&rft.aufirst=SH&rft.date=2008-02-29&rft.volume=331&rft.issue=1-2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2007.11.004 LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area. AN - 733919692; 19046442 AB - The production and use of nanoparticles is growing rapidly due to the unique physical and chemical properties associated with their nano size and large surface area. Since nanoparticles have unique physicochemical properties, their bioactivity upon exposure to workers or consumers is of interest. In this study, the issue of what dose metric (mass dose versus surface area dose) is appropriate for toxicological studies has been addressed. Rats were exposed by intratracheal instillation to various doses of ultrafine or fine TiO2. At 1, 7, or 42 days post-exposure, inflammatory and cytotoxic potential of each particle type was compared on both a mass dosage (mg/rat) as well as an equal surface area dosage (cm2 of particles per cm2 of alveolar epithelium) basis. The findings of the study show that on a mass basis the ultrafine particles caused significantly more inflammation and were significantly more cytotoxic than the fine sized particles. However, when doses were equalized based on surface area of particles delivered, the ultrafine particles were only slightly more inflammogenic and cytotoxic when compared to the fine sized particles. Lung burden data indicate that ultrafine TiO2 appears to migrate to the interstitium to a much greater extent than fine TiO2. This study suggests that surface area of particles may be a more appropriate dose metric for pulmonary toxicity studies than mass of particles. JF - Particle and fibre toxicology AU - Sager, Tina M AU - Kommineni, C AU - Castranova, Vincent AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. vic1@cdc.gov. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 17 VL - 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733919692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Pulmonary+response+to+intratracheal+instillation+of+ultrafine+versus+fine+titanium+dioxide%3A+role+of+particle+surface+area.&rft.au=Sager%2C+Tina+M%3BKommineni%2C+C%3BCastranova%2C+Vincent&rft.aulast=Sager&rft.aufirst=Tina&rft.date=2008-12-01&rft.volume=5&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-5-17 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Inhal Toxicol. 1996;8 Suppl:73-89 [11542496] Methods Enzymol. 1987;154:498-511 [3431461] J Toxicol Environ Health A. 2002 Aug 23;65(16):1121-40 [12167212] Inhal Toxicol. 2007 Aug;19(10):849-56 [17687716] Fundam Appl Toxicol. 1988 Apr;10(3):369-84 [3286345] Occup Environ Med. 2007 Sep;64(9):609-15 [17409182] Inhal Toxicol. 2000 Jan-Feb;12(1-2):1-17 [10715616] J Am Chem Soc. 2002 Dec 25;124(51):15198-207 [12487595] Inhal Toxicol. 2000 Dec;12(12):1113-26 [11114784] Am J Respir Cell Mol Biol. 1992 May;6(5):535-42 [1581076] Environ Health Perspect. 1994 Oct;102 Suppl 5:173-9 [7882925] Methods Enzymol. 1986;132:498-507 [3821523] Environ Health Perspect. 2007 Mar;115(3):397-402 [17431489] Toxicology. 2007 Jan 25;230(1):90-104 [17196727] Toxicol Sci. 2006 May;91(1):227-36 [16495353] J Aerosol Med. 2002 Summer;15(2):213-20 [12184871] Toxicol Sci. 2006 Jul;92(1):174-85 [16613837] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1743-8977-5-17 ER - TY - JOUR T1 - Cumulative sensitization and disease in a beryllium oxide ceramics worker cohort. AN - 69904655; 19092488 AB - We followed a cohort of 136 beryllium oxide ceramics workers from 1992 to 2003, including those who left employment, for beryllium sensitization and chronic beryllium disease (CBD). We invited the cohort's participation in current worker surveys in 1992, 1998, 2000, and 2002-2003, and in former worker surveys in 2000-2001 and 2003. We calculated 11-year cumulative incidences (after 1992 initial survey) of sensitization and CBD, both crude and corrected for interval censoring; and period prevalences (including 1992 findings), crude and corrected. In 1992, point prevalences were 6% sensitized and 4% CBD. We obtained follow-up on 83% of 128 not sensitized in 1992. Crude cumulative incidences for sensitization and CBD were 13% and 9%, respectively; corrected were 15% and 11%. Crude period prevalences for sensitization and CBD were 16% and 11%, respectively; corrected were 20% and 14%. Corrected period prevalences for pre-1992 machining work were 30% and 20%. With repeated testing over 11 years, total sensitization and CBD in this cohort were triple initial 1992 survey results. JF - Journal of occupational and environmental medicine AU - Schuler, Christine R AU - Kitt, Margaret M AU - Henneberger, Paul K AU - Deubner, David C AU - Kreiss, Kathleen AD - Division of Respiratory Disease Studies, Field Studies Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WVa 26505, USA. christine.schuler@cdc.hhs.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1343 EP - 1350 VL - 50 IS - 12 KW - beryllium oxide KW - 2S8NLR37S3 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Bronchoscopes KW - Humans KW - Aged KW - Lymphocytes KW - Smoking -- epidemiology KW - Ceramics KW - Adult KW - Cohort Studies KW - Surveys and Questionnaires KW - Incidence KW - Middle Aged KW - Chronic Disease KW - Chemical Industry KW - Female KW - Male KW - Proportional Hazards Models KW - Hypersensitivity -- epidemiology KW - Berylliosis -- blood KW - Hypersensitivity -- etiology KW - Berylliosis -- epidemiology KW - Occupational Exposure -- adverse effects KW - Beryllium -- adverse effects KW - Beryllium -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69904655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Cumulative+sensitization+and+disease+in+a+beryllium+oxide+ceramics+worker+cohort.&rft.au=Schuler%2C+Christine+R%3BKitt%2C+Margaret+M%3BHenneberger%2C+Paul+K%3BDeubner%2C+David+C%3BKreiss%2C+Kathleen&rft.aulast=Schuler&rft.aufirst=Christine&rft.date=2008-12-01&rft.volume=50&rft.issue=12&rft.spage=1343&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=1536-5948&rft_id=info:doi/10.1097%2FJOM.0b013e31818def24 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2008-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JOM.0b013e31818def24 ER - TY - JOUR T1 - Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide. AN - 69872593; 18800343 AB - The discovery of acrylamide (AA) in a variety of fried foods has raised public health concerns. In this study, groups of male mice were administered 500 mg/L AA in drinking water for 3 weeks, and gene expression changes were evaluated in the livers of AA-treated mice within 24 hr of the last treatment. When a two-fold cutoff value and a P-value less than 0.05 were selected, 696 genes (233 up-regulated and 463 down-regulated) were identified as differentially expressed genes in AA-treated mice when compared with the controls. Gene ontology analysis revealed that the principle pathways affected by AA were xenobiotic metabolism by cytochrome P450 (CYPs) and glutathione metabolism, suggesting that drug and/or xenobiotic metabolism is most affected by exposure. The results provide more information about AA metabolism and further insight into the molecular mechanisms involved in AA-induced toxicity. JF - Environmental and molecular mutagenesis AU - Mei, Nan AU - Guo, Lei AU - Tseng, Jo AU - Dial, Stacey L AU - Liao, Wayne AU - Manjanatha, Mugimane G AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. nan.mei@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 741 EP - 745 VL - 49 IS - 9 KW - Xenobiotics KW - 0 KW - Acrylamide KW - 20R035KLCI KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Cytochrome P-450 Enzyme System -- genetics KW - Xenobiotics -- metabolism KW - Glutathione Transferase -- metabolism KW - Xenobiotics -- pharmacology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Mice KW - Glutathione Transferase -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Gene Expression -- drug effects KW - Gene Expression Profiling KW - Acrylamide -- metabolism KW - Acrylamide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69872593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Gene+expression+changes+associated+with+xenobiotic+metabolism+pathways+in+mice+exposed+to+acrylamide.&rft.au=Mei%2C+Nan%3BGuo%2C+Lei%3BTseng%2C+Jo%3BDial%2C+Stacey+L%3BLiao%2C+Wayne%3BManjanatha%2C+Mugimane+G&rft.aulast=Mei&rft.aufirst=Nan&rft.date=2008-12-01&rft.volume=49&rft.issue=9&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20429 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20429 ER - TY - JOUR T1 - Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD. AN - 69860429; 18978633 AB - In response to previously published findings of methylphenidate-induced chromosomal changes in children, this study was designed to determine whether methylphenidate- or amphetamine-based drugs induce chromosomal damage (structural aberrations, micronuclei, and sister chromatid exchanges) in peripheral blood lymphocytes of children with attention-deficit/hyperactivity disorder after 3 months of continuous treatment. Stimulant drug-naïve subjects, 6 to 12 years of age, in good overall health, and judged to be appropriate candidates for stimulant therapy based on rigorously diagnosed ADHD using DSM-IV criteria, were randomized into two open-label treatment groups (methylphenidate or mixed amphetamine salts). Each subject provided a blood sample before initiation of treatment and after 3 months of treatment. Pretreatment and posttreatment frequencies of chromosomal aberrations, micronuclei, and sister chromatid exchanges were determined for each subject. Sixty-three subjects enrolled in the study; 47 subjects completed the full 3 months of treatment, 25 in the methylphenidate group and 22 in the amphetamine group. No significant treatment-related increases were observed in any of the three measures of cytogenetic damage in the 47 subjects who completed treatment or the 16 subjects who did not. Earlier findings of methylphenidate-induced chromosomal changes in children were not replicated in this study. These results add to the accumulating evidence that therapeutic levels of methylphenidate do not induce cytogenetic damage in humans. Furthermore, our results indicate that amphetamine-based products do not pose a risk for cytogenetic damage in children. JF - Journal of the American Academy of Child and Adolescent Psychiatry AU - Witt, Kristine L AU - Shelby, Michael D AU - Itchon-Ramos, Nilda AU - Faircloth, Melissa AU - Kissling, Grace E AU - Chrisman, Allan K AU - Ravi, Hima AU - Murli, Hemalatha AU - Mattison, Donald R AU - Kollins, Scott H AD - National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Triangle Park, NC 27709, USA. witt@niehs.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1375 EP - 1383 VL - 47 IS - 12 KW - Adderall KW - 0 KW - Amphetamines KW - Central Nervous System Stimulants KW - SLI381 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Lymphocytes -- metabolism KW - Child KW - Lymphocytes -- drug effects KW - Male KW - Female KW - Attention Deficit Disorder with Hyperactivity -- genetics KW - Micronucleus Tests KW - Amphetamines -- therapeutic use KW - Sister Chromatid Exchange KW - Central Nervous System Stimulants -- toxicity KW - Chromosome Aberrations KW - Methylphenidate -- therapeutic use KW - Central Nervous System Stimulants -- therapeutic use KW - Methylphenidate -- toxicity KW - Attention Deficit Disorder with Hyperactivity -- drug therapy KW - Amphetamines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69860429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+and+Adolescent+Psychiatry&rft.atitle=Methylphenidate+and+amphetamine+do+not+induce+cytogenetic+damage+in+lymphocytes+of+children+with+ADHD.&rft.au=Witt%2C+Kristine+L%3BShelby%2C+Michael+D%3BItchon-Ramos%2C+Nilda%3BFaircloth%2C+Melissa%3BKissling%2C+Grace+E%3BChrisman%2C+Allan+K%3BRavi%2C+Hima%3BMurli%2C+Hemalatha%3BMattison%2C+Donald+R%3BKollins%2C+Scott+H&rft.aulast=Witt&rft.aufirst=Kristine&rft.date=2008-12-01&rft.volume=47&rft.issue=12&rft.spage=1375&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+and+Adolescent+Psychiatry&rft.issn=1527-5418&rft_id=info:doi/10.1097%2FCHI.0b013e3181893620 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2008-12-03 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00341029; ClinicalTrials.gov N1 - SuppNotes - Cited By: Arch Pediatr Adolesc Med. 1999 Dec;153(12):1257-63 [10591302] Cancer Lett. 2008 Feb 18;260(1-2):216-8 [18055105] JAMA. 2000 Feb 23;283(8):1025-30 [10697062] Ann Clin Psychiatry. 2000 Mar;12(1):55-62 [10798827] Pediatrics. 2000 May;105(5):1158-70 [10836893] Pediatrics. 2000 Sep;106(3):533-9 [10969099] Mutat Res. 2003 May 9;537(1):67-79 [12742508] Biol Psychiatry. 2003 Dec 15;54(12):1307-9 [14675792] Cytogenet Genome Res. 2004;104(1-4):376-82 [15162068] J Learn Disabil. 2000 Jul-Aug;33(4):314; author reply 314-6 [15493092] Environ Mutagen. 1986;8 Suppl 7:1-119 [3516675] Environ Mol Mutagen. 1987;10 Suppl 10:1-175 [3319609] Mutat Res. 1989 Jun;212(2):149-54 [2733711] Cancer Res. 1989 Oct 15;49(20):5736-47 [2571410] J Am Acad Child Adolesc Psychiatry. 1997 Sep;36(9):1311-7 [9291734] J Am Acad Child Adolesc Psychiatry. 1997 Oct;36(10 Suppl):85S-121S [9334567] J Learn Disabil. 1998 Nov-Dec;31(6):533-44 [9813951] J Am Acad Child Adolesc Psychiatry. 1999 May;38(5):503-12 [10230181] Environ Health Perspect. 2005 Sep;113(9):1226-9 [16140632] Cancer Lett. 2005 Dec 18;230(2):292-4 [16019134] Cancer Lett. 2005 Dec 18;230(2):284-91 [16297714] Cancer Lett. 2006 Jan 8;231(1):146-8 [16290920] N Engl J Med. 2006 Apr 6;354(14):1445-8 [16549404] Mutat Res. 2006 Sep 5;607(2):153-9 [16829163] J Am Acad Child Adolesc Psychiatry. 2006 Oct;45(10):1147-50 [16840880] Biol Psychiatry. 2007 Mar 1;61(5):706-12 [16899230] Carcinogenesis. 2007 Mar;28(3):625-31 [16973674] Environ Mol Mutagen. 2007 Apr-May;48(3-4):322-9 [17358032] J Atten Disord. 2007 May;10(4):335-42 [17449832] Environ Health Perspect. 2007 Jun;115(6):936-40 [17589603] Expert Opin Pharmacother. 2007 Sep;8(13):2127-34 [17714065] J Manag Care Pharm. 2007 Sep;13(7):561-9 [17874862] Pharmacoepidemiol Drug Saf. 2007 Dec;16(12):1268-72 [18041106] J Am Acad Child Adolesc Psychiatry. 2000 Jan;39(1):28-38 [10638065] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/CHI.0b013e3181893620 ER - TY - JOUR T1 - Kinematics and kinetics of gait on stilts: identification of risk factors associated with construction stilt use. AN - 69828234; 18608480 AB - This study investigated kinematics and kinetic strategies and identified risk factors associated with gait on stilts. A six-camera motion-analysis system and two force platforms were used to test 20 construction workers for straight walking or turning, with or without carrying tools while wearing safety shoes or stilts at different heights. The results indicated that gait on stilts is characterised by increases in stride length, step width and the percentage of double support period, decreases in cadence, minimum foot clearance and a weaker heel-strike and push-off. Stilts place greater joint loadings on lower extremities to compensate for the added weight and limitation in joint mobility. Smaller foot clearances found for gait on stilts constitute an increased risk for tripping over obstacles. Workers may need to avoid prolonged use of stilts to alleviate stresses on the joints. This study was conducted to determine to what extent stilts alter the gait strategies and to explain the compensatory movements. Prior to this study, there has been little substantive research to evaluate the stresses and potential injuries associated with stilts. JF - Ergonomics AU - Chiou, Sharon S AU - Pan, Christopher S AU - Bhattacharya, Amit AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. schiou@cdc.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1814 EP - 1829 VL - 51 IS - 12 SN - 0014-0139, 0014-0139 KW - Index Medicus KW - Space life sciences KW - Occupational Exposure KW - Risk Factors KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Equipment Design KW - Postural Balance -- physiology KW - Biomechanical Phenomena KW - Gait -- physiology KW - Facility Design and Construction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69828234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Kinematics+and+kinetics+of+gait+on+stilts%3A+identification+of+risk+factors+associated+with+construction+stilt+use.&rft.au=Chiou%2C+Sharon+S%3BPan%2C+Christopher+S%3BBhattacharya%2C+Amit&rft.aulast=Chiou&rft.aufirst=Sharon&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=1814&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130801961885 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/00140130801961885 ER - TY - JOUR T1 - Wearing an N95 respirator concurrently with a powered air-purifying respirator: effect on protection factor. AN - 69825980; 19025703 AB - To determine if using an N95 filtering face-piece respirator concurrently with a loose-fitting powered air-purifying respirator (PAPR) offers additional protection to the wearer. We used a breathing mannequin programmed to deliver minute volumes of 25 L/min and 40 L/min. We measured the baseline protection factor of the PAPR with its motor operational and then deactivated (to simulate mechanical or battery failure). We tested 3 replicates of 3 different N95 models. We glued each N95 to the breathing mannequin and obtained a minimum protection factor of 100 at 25 L/min. We then placed the PAPR on the mannequin and took protection factor measurements with the N95-plus-PAPR combination, at 25 L/min and 40 L/min, with the PAPR operational and then deactivated. The N95 significantly increased the PAPR's protection factor, even with the PAPR deactivated. The effect was multiplicative, not merely additive. An N95 decreases the concentration of airborne particles inspired by the wearer of a PAPR. JF - Respiratory care AU - Roberge, Marc R AU - Vojtko, Mark R AU - Roberge, Raymond J AU - Vojtko, Richard J AU - Landsittel, Douglas P AD - National Personal Protective Technology Laboratory of National Institute for Occupational Safety and Health of Centers for Disease Control and Prevention, PO Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA. dtn0@cdc.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1685 EP - 1690 VL - 53 IS - 12 SN - 0020-1324, 0020-1324 KW - Index Medicus KW - Equipment Design KW - Equipment Failure Analysis KW - Humans KW - Adult KW - Manikins KW - Models, Biological KW - Respiratory Protective Devices KW - Inhalation Exposure -- prevention & control KW - Air Microbiology KW - Disease Transmission, Infectious -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69825980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Respiratory+care&rft.atitle=Wearing+an+N95+respirator+concurrently+with+a+powered+air-purifying+respirator%3A+effect+on+protection+factor.&rft.au=Roberge%2C+Marc+R%3BVojtko%2C+Mark+R%3BRoberge%2C+Raymond+J%3BVojtko%2C+Richard+J%3BLandsittel%2C+Douglas+P&rft.aulast=Roberge&rft.aufirst=Marc&rft.date=2008-12-01&rft.volume=53&rft.issue=12&rft.spage=1685&rft.isbn=&rft.btitle=&rft.title=Respiratory+care&rft.issn=00201324&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Respir Care. 2008 Dec;53(12):1660-4 [19025698] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute pesticide poisoning among agricultural workers in the United States, 1998-2005. AN - 69824786; 18666136 AB - Approximately 75% of pesticide usage in the United States occurs in agriculture. As such, agricultural workers are at greater risk of pesticide exposure than non-agricultural workers. However, the magnitude, characteristics and trend of acute pesticide poisoning among agricultural workers are unknown. We identified acute pesticide poisoning cases in agricultural workers between the ages of 15 and 64 years that occurred from 1998 to 2005. The California Department of Pesticide Regulation and the SENSOR-Pesticides program provided the cases. Acute occupational pesticide poisoning incidence rates (IR) for those employed in agriculture were calculated, as were incidence rate ratios (IRR) among agricultural workers relative to non-agricultural workers. Of the 3,271 cases included in the analysis, 2,334 (71%) were employed as farmworkers. The remaining cases were employed as processing/packing plant workers (12%), farmers (3%), and other miscellaneous agricultural workers (19%). The majority of cases had low severity illness (N = 2,848, 87%), while 402 (12%) were of medium severity and 20 (0.6%) were of high severity. One case was fatal. Rates of illness among various agricultural worker categories were highly variable but all, except farmers, showed risk for agricultural workers greater than risk for non-agricultural workers by an order of magnitude or more. Also, the rate among female agricultural workers was almost twofold higher compared to males. The findings from this study suggest that acute pesticide poisoning in the agricultural industry continues to be an important problem. These findings reinforce the need for heightened efforts to better protect farmworkers from pesticide exposure. Copyright 2008 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Calvert, Geoffrey M AU - Karnik, Jennifer AU - Mehler, Louise AU - Beckman, John AU - Morrissey, Barbara AU - Sievert, Jennifer AU - Barrett, Rosanna AU - Lackovic, Michelle AU - Mabee, Laura AU - Schwartz, Abby AU - Mitchell, Yvette AU - Moraga-McHaley, Stephanie AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA. jac6@cdc.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 883 EP - 898 VL - 51 IS - 12 KW - Pesticides KW - 0 KW - Index Medicus KW - Severity of Illness Index KW - Acute Disease KW - Young Adult KW - Humans KW - Retrospective Studies KW - Risk Assessment KW - Age Distribution KW - Survival Rate KW - Pest Control KW - Adult KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Male KW - Occupational Exposure KW - Agricultural Workers' Diseases -- epidemiology KW - Pesticides -- poisoning KW - Agricultural Workers' Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69824786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Acute+pesticide+poisoning+among+agricultural+workers+in+the+United+States%2C+1998-2005.&rft.au=Calvert%2C+Geoffrey+M%3BKarnik%2C+Jennifer%3BMehler%2C+Louise%3BBeckman%2C+John%3BMorrissey%2C+Barbara%3BSievert%2C+Jennifer%3BBarrett%2C+Rosanna%3BLackovic%2C+Michelle%3BMabee%2C+Laura%3BSchwartz%2C+Abby%3BMitchell%2C+Yvette%3BMoraga-McHaley%2C+Stephanie&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.20623 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20623 ER - TY - JOUR T1 - Proportionate mortality study of the United Association of Journeymen and Apprentices of the Plumbing and Pipe Fitting Industry. AN - 69819087; 18942099 AB - This study examined causes of deaths among unionized plumbers, pipefitters and allied trades. Deaths of union members from the years 1971, 1979, 1987, and 1995 were selected as a representative sample from a computer file provided by the union. These years provided 15,411 deaths for proportionate mortality ratio (PMR) analysis. PMRs for lung cancer and asbestosis were significantly elevated compared to U.S. white males. PMRs for chronic disease of the endocardium and cardiomyopathy were also elevated. Elevations were not observed in other a priori causes: laryngeal cancer, lymphatic cancer, and neurological disorders. PMRs for transportation accidents for pipe/steam-fitters were elevated in 1971 and 1979, but not in 1987 or 1995. Despite the limitations of a PMR analysis, study results indicate mortality related to asbestos exposure is, and will continue to be, an area of concern for members of the union. Copyright 2008 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Lehman, Everett J AU - Hein, Misty J AU - Estill, Cheryl F AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. elehman@cdc.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 950 EP - 963 VL - 51 IS - 12 KW - Index Medicus KW - Causality KW - Young Adult KW - Occupational Health KW - Humans KW - Retrospective Studies KW - Hematologic Neoplasms -- mortality KW - Cardiovascular Diseases -- mortality KW - Asbestosis -- mortality KW - Labor Unions KW - Adult KW - Databases, Factual KW - Lung Neoplasms -- mortality KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Survival Analysis KW - Occupational Exposure KW - Metallurgy KW - Cause of Death KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69819087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Proportionate+mortality+study+of+the+United+Association+of+Journeymen+and+Apprentices+of+the+Plumbing+and+Pipe+Fitting+Industry.&rft.au=Lehman%2C+Everett+J%3BHein%2C+Misty+J%3BEstill%2C+Cheryl+F&rft.aulast=Lehman&rft.aufirst=Everett&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=950&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.20640 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20640 ER - TY - JOUR T1 - Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide. AN - 69778523; 18812491 AB - A variety of peptide ligands are known to inhibit the function of neuronal nicotinic acetylcholine receptors (nAChRs), including small toxins and brain-derived peptides such as beta-amyloid(1-42) and synthetic apolipoproteinE peptides. The myristoylated alanine-rich C kinase substrate (MARCKS) protein is a major substrate of protein kinase C and is highly expressed in the developing and adult brain. The ability of a 25-amino acid synthetic MARCKS peptide, derived from the effector domain (ED), to modulate nAChR activity was tested. To determine the effects of the MARCKS ED peptide on nAChR function, receptors were expressed in Xenopus laevis oocytes, and two-electrode voltage-clamp experiments were performed. The MARCKS ED peptide completely inhibited acetylcholine (ACh)-evoked responses from alpha7 nAChRs in a dose-dependent manner, yielding an IC(50) value of 16 nM. Inhibition of ACh-induced responses was both activity- and voltage-independent. The MARCKS ED peptide was unable to block alpha-bungarotoxin binding. A MARCKS ED peptide in which four serine residues were replaced with aspartate residues was unable to inhibit alpha7 nAChR-mediated currents. The MARCKS ED peptide inhibited ACh-induced alpha4beta2 and alpha2beta2 responses, although with decreased potency. The effects of the MARCKS ED peptide on native nAChRs were tested using acutely isolated rat hippocampal slices. In hippocampal interneurons, the MARCKS ED peptide was able to block native alpha7 nAChRs in a dose-dependent manner. The MARCKS ED peptide represents a novel antagonist of neuronal nAChRs that has considerable utility as a research tool. JF - The Journal of pharmacology and experimental therapeutics AU - Gay, Elaine A AU - Klein, Rebecca C AU - Melton, Mark A AU - Blackshear, Perry J AU - Yakel, Jerrel L AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 884 EP - 890 VL - 327 IS - 3 KW - Chrna7 protein, human KW - 0 KW - Chrna7 protein, rat KW - Intracellular Signaling Peptides and Proteins KW - Membrane Proteins KW - Nicotinic Antagonists KW - Receptors, Nicotinic KW - Recombinant Proteins KW - alpha7 Nicotinic Acetylcholine Receptor KW - myristoylated alanine-rich C kinase substrate KW - 125267-21-2 KW - Index Medicus KW - Rats KW - Xenopus laevis KW - Animals KW - Dose-Response Relationship, Drug KW - Oocytes KW - Inhibitory Concentration 50 KW - Electrophysiology KW - Mutation, Missense KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Receptors, Nicotinic -- drug effects KW - Membrane Proteins -- genetics KW - Intracellular Signaling Peptides and Proteins -- physiology KW - Membrane Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69778523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Inhibition+of+native+and+recombinant+nicotinic+acetylcholine+receptors+by+the+myristoylated+alanine-rich+C+kinase+substrate+peptide.&rft.au=Gay%2C+Elaine+A%3BKlein%2C+Rebecca+C%3BMelton%2C+Mark+A%3BBlackshear%2C+Perry+J%3BYakel%2C+Jerrel+L&rft.aulast=Gay&rft.aufirst=Elaine&rft.date=2008-12-01&rft.volume=327&rft.issue=3&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.144758 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-05 N1 - Date created - 2008-11-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2006 Sep;318(3):956-65 [16740622] Hippocampus. 2006;16(5):495-503 [16572394] J Pharmacol Exp Ther. 2001 Aug;298(2):395-402 [11454899] Mol Pharmacol. 2002 Jan;61(1):43-54 [11752205] Biochem J. 2002 Feb 15;362(Pt 1):1-12 [11829734] J Physiol. 2000 Sep 15;527 Pt 3:515-28 [10990538] J Neurosci. 2001 Jan 1;21(1):RC120 [11150356] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4734-9 [11274373] Eur J Neurosci. 2001 May;13(10):1849-60 [11403678] J Biol Chem. 2002 Jul 12;277(28):25056-61 [11983690] J Physiol. 2003 Feb 15;547(Pt 1):147-57 [12562926] Nat Struct Biol. 2003 Mar;10(3):226-31 [12577052] Br J Pharmacol. 2003 Jul;139(6):1061-73 [12871824] J Neurosci. 2003 Jul 30;23(17):6740-7 [12890766] J Neurosci. 2003 Oct 8;23(27):9024-31 [14534236] Biochem Cell Biol. 2004 Feb;82(1):191-200 [15052337] J Neurochem. 2004 Jul;90(2):325-31 [15228589] Neuroscience. 2004;127(3):563-7 [15283956] J Biol Chem. 2004 Sep 3;279(36):37842-51 [15234980] J Physiol. 1988 Jan;395:131-59 [2457675] J Biol Chem. 1989 Dec 25;264(36):21818-23 [2557340] J Neurosci. 1990 May;10(5):1683-98 [2332803] J Biol Chem. 1991 Aug 5;266(22):14390-8 [1650359] Cell. 1992 Nov 27;71(5):713-6 [1423627] J Physiol. 1992 Aug;454:155-82 [1282155] J Biol Chem. 1993 Jan 25;268(3):1501-4 [8420923] Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):944-8 [7862670] J Biol Chem. 1996 Jan 5;271(1):553-62 [8550618] J Biol Chem. 1997 Sep 19;272(38):23833-42 [9295331] Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14517-22 [9826732] Exp Neurol. 2005 Mar;192(1):109-16 [15698624] Neurosci Lett. 2005 Jun 24;381(3):305-8 [15896489] Hippocampus. 2005;15(5):675-83 [15889447] J Mol Neurosci. 2005;27(1):13-21 [16055943] Neuron. 2005 Oct 6;48(1):77-90 [16202710] J Pharmacol Exp Ther. 2006 Feb;316(2):835-42 [16249370] Biochem Pharmacol. 2007 Oct 15;74(8):1092-101 [17662959] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.144758 ER - TY - JOUR T1 - Racial/ethnic and gender differences in individual workplace injury risk trajectories: 1988-1998. AN - 69775586; 18235072 AB - I examined workplace injury risk over time and across racial/ethnic and gender groups to observe patterns of change and to understand how occupational characteristics and job mobility influence these changes. I used hierarchical generalized linear models to estimate individual workplace injury and illness risk over time ("trajectories") for a cohort of American workers who participated in the National Longitudinal Survey of Youth (1988-1998). Significant temporal variation in injury risk was observed across racial/ethnic and gender groups. At baseline, White men had a high risk of injury relative to the other groups and experienced the greatest decline over time. Latino men demonstrated a pattern of lower injury risk across time compared with White men. Among both Latinos and non-Latino Whites, women had lower odds of injury than did men. Non-Latino Black women's injury risk was similar to Black men's and greater than that for both Latino and non-Latino White women. Occupational characteristics and job mobility partly explained these differences. Disparities between racial/ethnic and gender groups were dynamic and changed over time. Workplace injury risk was associated with job dimensions such as work schedule, union representation, health insurance, job hours, occupational racial segregation, and occupational environmental hazards. JF - American journal of public health AU - Berdahl, Terceira A AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. terceira.berdahl@ahrq.hhs.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2258 EP - 2263 VL - 98 IS - 12 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Linear Models KW - Minority Groups -- statistics & numerical data KW - Longitudinal Studies KW - Vulnerable Populations -- statistics & numerical data KW - Population Surveillance KW - Risk Assessment KW - Risk Factors KW - Health Surveys KW - Surveys and Questionnaires KW - Health Status Disparities KW - Occupations -- statistics & numerical data KW - United States -- epidemiology KW - Time Factors KW - Sex Distribution KW - Female KW - Male KW - Hispanic Americans -- statistics & numerical data KW - Accidents, Occupational -- trends KW - Wounds and Injuries -- etiology KW - African Americans -- statistics & numerical data KW - European Continental Ancestry Group -- statistics & numerical data KW - Wounds and Injuries -- ethnology KW - Workplace -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69775586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Racial%2Fethnic+and+gender+differences+in+individual+workplace+injury+risk+trajectories%3A+1988-1998.&rft.au=Berdahl%2C+Terceira+A&rft.aulast=Berdahl&rft.aufirst=Terceira&rft.date=2008-12-01&rft.volume=98&rft.issue=12&rft.spage=2258&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=1541-0048&rft_id=info:doi/10.2105%2FAJPH.2006.103135 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-02 N1 - Date created - 2008-11-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Occup Environ Med. 2000 Oct;42(10):1035-40 [11039167] Am J Public Health. 2003 Feb;93(2):221-6 [12554573] Soc Sci Med. 2003 Dec;57(11):2173-82 [14512247] Ergonomics. 2004 Apr 15;47(5):495-526 [15204301] Milbank Mem Fund Q Health Soc. 1984 Fall;62(4):567-90 [6569359] J Occup Med. 1993 Sep;35(9):916-21 [8229344] Am J Public Health. 2007 Jun;97(6):1096-101 [17463379] Am J Public Health. 1998 Jan;88(1):40-4 [9584031] Am J Public Health. 2005 Mar;95(3):483-8 [15727981] Am J Public Health. 2005 Jul;95(7):1213-9 [15983273] Am J Public Health. 2005 Jul;95(7):1226-32 [15983275] Am J Public Health. 2007 May;97(5):919-25 [17395846] Am J Public Health. 1994 Nov;84(11):1846-8 [7977933] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2105/AJPH.2006.103135 ER - TY - JOUR T1 - Differentiating non-asbestiform amphibole and amphibole asbestos by size characteristics. AN - 69617004; 18828048 AB - Mining or processing asbestos minerals can liberate isolated fibers or fiber bundles regulated as airborne asbestos fibers. Coarsely crystalline amphibole minerals are more common than asbestos in many geologic environments, and disturbance can result in the release of prismatic or acicular single crystals or cleavage fragments resembling asbestos fibers or fiber bundles but that are not currently regulated as asbestos. Bulk samples of six coarsely crystalline amphiboles and their five asbestos analogs were processed to maximize the number of particles meeting the criterion for counting under the current U.S. National Institute for Occupational Safety and Health Method 7400 "A" counting rules (> 5 microm long with an aspect ratio >or= 3:1) and also within the respirable width range, i.e. < 3 microm width. The length distributions of the particles produced showed substantial overlap between cleavage fragments and asbestos fibers. Available data sets generally confirmed the relevance of the size distributions of particles generated from reference materials to airborne particles. The length criterion in the current ASTM International standard D7200-06 causes a large proportion (e.g., 40% grunerite and 39% tremolite) of the non-asbestiform particles to be considered potential asbestos. An alternative procedure may be to use a distinction based on width alone as some, but not the majority of, cleavage fragments were thinner than 1 microm (e.g., 9% of actinolite and 20% of grunerite particles), and not many amphibole asbestos particles were wider (e.g., 5% of crocidolite and 18% of amosite particles). This proposal would need further testing. This research should not be considered as addressing any controversy with regard to the toxicity of non-asbestiform amphibole particles of similar dimensions to asbestos particles. JF - Journal of occupational and environmental hygiene AU - Harper, Martin AU - Lee, Eun Gyung AU - Doorn, Stacy S AU - Hammond, Okisha AD - Health Effects Laboratory Division, Exposure Assessment Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. zzg7@cdc.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 761 EP - 770 VL - 5 IS - 12 KW - Air Pollutants, Occupational KW - 0 KW - Asbestos, Amphibole KW - Particulate Matter KW - Index Medicus KW - United States KW - Particle Size KW - United States Occupational Safety and Health Administration KW - Guidelines as Topic KW - Environmental Monitoring -- methods KW - Air Pollutants, Occupational -- analysis KW - Asbestos, Amphibole -- chemistry KW - Particulate Matter -- chemistry KW - Particulate Matter -- analysis KW - Air Pollutants, Occupational -- chemistry KW - Occupational Exposure -- analysis KW - Asbestos, Amphibole -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69617004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Differentiating+non-asbestiform+amphibole+and+amphibole+asbestos+by+size+characteristics.&rft.au=Harper%2C+Martin%3BLee%2C+Eun+Gyung%3BDoorn%2C+Stacy+S%3BHammond%2C+Okisha&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2008-12-01&rft.volume=5&rft.issue=12&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620802462290 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620802462290 ER - TY - JOUR T1 - Recurring outbreaks of Salmonella typhimurium phage type 135 associated with the consumption of products containing raw egg in Tasmania. AN - 66712873; 19374277 AB - Large egg-associated outbreaks of Salmonella Typhimurium 135 (STm135) that were associated with inadequate food safety practices but also linked to a common poultry farm occurred in Tasmania in 2005. A series of public health interventions were implemented to prevent further occurrences but 2 more egg-associated outbreaks in Tasmania in March 2007 and January 2008 led to a further 66 cases of STm135. This report describes these outbreaks and their links to the common source associated with the outbreaks in 2005. JF - Communicable diseases intelligence quarterly report AU - Stephens, Nicola AU - Coleman, David AU - Shaw, Kathleen AD - Communicable Diseases Prevention Unit, Department of Health and Human Services, Hobart, Tasmania. nicola.stephens@dhhs.tas.gov.au Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 466 EP - 468 VL - 32 IS - 4 SN - 1447-4514, 1447-4514 KW - Index Medicus KW - Tasmania -- epidemiology KW - Animals KW - Food Microbiology KW - Humans KW - Cooking KW - Food Contamination KW - Salmonella Food Poisoning -- epidemiology KW - Salmonella Food Poisoning -- microbiology KW - Time Factors KW - Eggs -- microbiology KW - Salmonella Infections -- microbiology KW - Salmonella Infections -- epidemiology KW - Disease Outbreaks KW - Salmonella typhimurium -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66712873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Communicable+diseases+intelligence+quarterly+report&rft.atitle=Recurring+outbreaks+of+Salmonella+typhimurium+phage+type+135+associated+with+the+consumption+of+products+containing+raw+egg+in+Tasmania.&rft.au=Stephens%2C+Nicola%3BColeman%2C+David%3BShaw%2C+Kathleen&rft.aulast=Stephens&rft.aufirst=Nicola&rft.date=2008-12-01&rft.volume=32&rft.issue=4&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Communicable+diseases+intelligence+quarterly+report&rft.issn=14474514&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-14 N1 - Date created - 2009-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rapid detection of Salmonella in foods using real-time PCR. AN - 66694972; 19256088 AB - Conventional methods for detection of Salmonella serovars in foods are generally time-consuming and labor intensive. A real-time PCR method has been developed with custom designed primers and a TaqMan probe to detect the presence of a 262-bp fragment of the Salmonella-specific invA gene. The method has been tested with a total of 384 field-isolated Salmonella serovars and non-Salmonella stock strains, as well as 420 U.S. Food and Drug Administration food samples, comprising a variety of food matrices. The method was highly specific in detecting Salmonella in spiked chili powder and shrimp samples, with a sensitivity of 0.04 CFU/g. In addition, the method is faster, more accurate, and less costly than the traditional U.S. Food and Drug Administration's Bacteriological Analytical Manual cell-culturing and the AOAC International-approved VIDAS methods to detect Salmonella in foods. JF - Journal of food protection AU - Cheng, Chorng-Ming AU - Lin, Wen AU - Van, Khanh Thien AU - Phan, Lieuchi AU - Tran, Nelly N AU - Farmer, Doris AD - U.S. Food and Drug Administration, Pacific Regional Laboratory Southwest, Irvine, California 92612, USA. chorng-ming.cheng@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2436 EP - 2441 VL - 71 IS - 12 SN - 0362-028X, 0362-028X KW - Bacterial Proteins KW - 0 KW - DNA, Bacterial KW - invA protein, Bacteria KW - 147652-43-5 KW - Index Medicus KW - Sensitivity and Specificity KW - Colony Count, Microbial -- methods KW - Food Microbiology KW - DNA, Bacterial -- chemistry KW - Humans KW - DNA, Bacterial -- genetics KW - Serotyping KW - Time Factors KW - Species Specificity KW - Gene Amplification KW - Salmonella enterica -- isolation & purification KW - Polymerase Chain Reaction -- methods KW - Food Contamination -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66694972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Rapid+detection+of+Salmonella+in+foods+using+real-time+PCR.&rft.au=Cheng%2C+Chorng-Ming%3BLin%2C+Wen%3BVan%2C+Khanh+Thien%3BPhan%2C+Lieuchi%3BTran%2C+Nelly+N%3BFarmer%2C+Doris&rft.aulast=Cheng&rft.aufirst=Chorng-Ming&rft.date=2008-12-01&rft.volume=71&rft.issue=12&rft.spage=2436&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-30 N1 - Date created - 2009-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systematic method for determining an ideal housekeeping gene for real-time PCR analysis. AN - 66671958; 19183798 AB - To standardize the amount of biological material between samples (e.g., number of cells or amount of tissue) for quantitative real-time reverse transcriptase PCR (qRT-PCR), the cycle of the target gene at which expression is detected (the cycle threshold, or Ct) is divided by the Ct of a gene either thought to be unaffected by experimental conditions or similarly expressed among donors. Genes that maintain cellular structure or homeostasis, referred to as housekeeping genes, or 18S ribosomal RNA are often used for this purpose. Although unstable or inconsistent housekeeping gene expression will misrepresent experimental effects on target gene expression, housekeeping genes are often chosen arbitrarily rather than systematically. We designed a simple and systematic approach towards selection of housekeeping genes based on Ct variance (as reflected by the standard deviation) and normality of distribution. We validated this approach by comparing stability and consistency of expression of 11 housekeeping genes across different types of cells, experimental treatments, and human donors. Finally, we demonstrated the consequences of inconsistent housekeeping gene expression on the calculation of target gene expression, and conclude that validation of stability of housekeeping gene expression by considering both distribution normality and standard deviation is straightforward and critical for proper experimental design. JF - Journal of biomolecular techniques : JBT AU - Mane, Viraj P AU - Heuer, Melissa A AU - Hillyer, Philippa AU - Navarro, Maria B AU - Rabin, Ronald L AD - Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892-4555, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 342 EP - 347 VL - 19 IS - 5 KW - Lipopolysaccharides KW - 0 KW - Ionomycin KW - 56092-81-0 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - housekeeping genes KW - cycle threshold KW - quantitative real time reverse transcriptase PCR (RT-CR) KW - CD4+ T cells KW - CD4-Positive T-Lymphocytes -- metabolism KW - Lipopolysaccharides -- pharmacology KW - Humans KW - Monocytes -- metabolism KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Monocytes -- drug effects KW - Ionomycin -- pharmacology KW - CD4-Positive T-Lymphocytes -- drug effects KW - Cell Line KW - Biotechnology KW - Gene Expression -- drug effects KW - Reverse Transcriptase Polymerase Chain Reaction -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66671958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomolecular+techniques+%3A+JBT&rft.atitle=Systematic+method+for+determining+an+ideal+housekeeping+gene+for+real-time+PCR+analysis.&rft.au=Mane%2C+Viraj+P%3BHeuer%2C+Melissa+A%3BHillyer%2C+Philippa%3BNavarro%2C+Maria+B%3BRabin%2C+Ronald+L&rft.aulast=Mane&rft.aufirst=Viraj&rft.date=2008-12-01&rft.volume=19&rft.issue=5&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomolecular+techniques+%3A+JBT&rft.issn=1943-4731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-02 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biotechnol Lett. 2004 Mar;26(6):509-15 [15127793] J Immunol. 1993 Aug 15;151(4):1938-49 [8102154] Blood. 1995 Aug 15;86(4):1408-19 [7632949] Biochem Biophys Res Commun. 1995 Dec 5;217(1):363-9 [8526935] Int Immunol. 2006 Mar;18(3):485-93 [16481346] Genome Biol. 2002 Jun 18;3(7):RESEARCH0034 [12184808] Methods. 2001 Dec;25(4):402-8 [11846609] Physiol Genomics. 2001 Dec 21;7(2):97-104 [11773596] Anal Biochem. 2002 Oct 15;309(2):293-300 [12413463] Biochem Biophys Res Commun. 1999 Jun 16;259(3):523-6 [10364451] Oncol Rep. 1998 Mar-Apr;5(2):469-71 [9468581] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The concept of sustainability and the use of outcome indicators. A case study to continue a successful health counselling intervention AN - 57280425; 200906445 AB - Background. To ensure the continuation of a successful pilot programme, the change process and the concept of sustainability need to be elaborated. So far, there are different theories on organizational change and sustainability but its practical application stay far behind. Objectives. To test the practical application of a theory-based concept of sustainability and to assess the role of the change agent. A health counselling programme for high-risk cardiovascular patients, called Heartbeat 2, was used as a case study. Methods. Outcome indicators were assessed based on the questions: Why should health counselling be sustained? How should this be done and by whom? How much needs to occur and by when? Data were derived from registrations, reports and focus group interviews. Results. The results indicate a need for a linkage system in the final stages of change so that the programme is maintained. Limitations of the external change agent are described. The outcome indicators appeared to be an adequate operationalization to monitor sustainability. The change process leading up to sustainability appeared to be highly complex due to unpredictable and unforeseen external factors. Conclusions. Our concept of sustainability appeared to be an adequate tool for the change agent to assess the extent of sustainability. An external change agent has limited influence on the management's decision-making processes during the sustainability stage. As long as the context is changing, definite choices to sustain the innovative service of health counselling in hospitals will not be made, which inherently means an ongoing change process to sustainability. Adapted from the source document. JF - Family Practice AU - Jansen, Maria AU - Harting, Janneke AU - Ebben, Nicole AU - Kroon, Bram AU - Stappers, Jan AU - Van Engelshoven, Esther AU - de Vries, Nanne AD - Public Health Service South Limburg Management, PO Box 2022, Geleen 6160, The Netherlands maria.jansen@ggdzl.nl Y1 - 2008/12// PY - 2008 DA - December 2008 SP - i32 EP - i37 PB - Oxford University Press VL - 25 IS - Supplement 1 SN - 0263-2136, 0263-2136 KW - Capacity planning, change agent, institutionalization, organizational development, sustainability KW - Change agents KW - Counselling KW - Organizational change KW - Sustainability KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57280425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+Practice&rft.atitle=The+concept+of+sustainability+and+the+use+of+outcome+indicators.+A+case+study+to+continue+a+successful+health+counselling+intervention&rft.au=Jansen%2C+Maria%3BHarting%2C+Janneke%3BEbben%2C+Nicole%3BKroon%2C+Bram%3BStappers%2C+Jan%3BVan+Engelshoven%2C+Esther%3Bde+Vries%2C+Nanne&rft.aulast=Jansen&rft.aufirst=Maria&rft.date=2008-12-01&rft.volume=25&rft.issue=Supplement+1&rft.spage=i32&rft.isbn=&rft.btitle=&rft.title=Family+Practice&rft.issn=02632136&rft_id=info:doi/10.1093%2Ffampra%2Fcmn066 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Sustainability; Change agents; Counselling; Hospitals; Organizational change DO - http://dx.doi.org/10.1093/fampra/cmn066 ER - TY - JOUR T1 - A few remarks on 'A capture-recapture approach for screening using two diagnostic tests with availability of disease status for the test positives only' by Böhning and Patilea AN - 37103475; 3843275 JF - Journal of the American Statistical Association AU - Chu, Haitao AU - Nie, Lei AD - University of North Carolina ; US Office of Biostatistics, Food and Drug Administration Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1518 EP - 1519 VL - 103 IS - 484 SN - 0162-1459, 0162-1459 KW - Sociology KW - Statistics KW - Medical research KW - Diseases KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37103475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=A+few+remarks+on+%27A+capture-recapture+approach+for+screening+using+two+diagnostic+tests+with+availability+of+disease+status+for+the+test+positives+only%27+by+B%C3%B6hning+and+Patilea&rft.au=Chu%2C+Haitao%3BNie%2C+Lei&rft.aulast=Chu&rft.aufirst=Haitao&rft.date=2008-12-01&rft.volume=103&rft.issue=484&rft.spage=1518&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F01621450800000094%3F%3F LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12233; 3617 6220; 7886 10902 DO - http://dx.doi.org/10.1198/01621450800000094?? ER - TY - JOUR T1 - An Unsupervised Neural Network to Predict the Level of Heat Stress AN - 217133509; 19031102 AB - Heat stress is known to induce high mortality rate due to multi-system illness, which demands urgent attention to reduce the fatality rate in such patients. Further, for the diagnosis and supportive therapy, one needs to define the severity of heat stress that can be distinguished as mild, intermediate and severe. The objective of this work is to develop an automated unsupervised artificial system to analyze the clinical outcomes of different levels of heat related illnesses. The Kohonen neural network program written in C++, which has seven normalized values of different clinical symptoms between 0-1 fed to the input layer of the network with 50 Kohonen output neurons, has been presented. The optimized initializing parameters such as neighborhood size and learning rate was set to 50 and 0.7, respectively, to simulate the network for 10 million iterations. The network was found smartly distinguishing all 51 patterns to three different states of heat illnesses. With the advent of these findings, it can be concluded that the Kohonen neural network can be used for automated classification of the severity of heat stress and other related psycho-patho-physiological disorders. However, to replace the expert clinicians with such type of smart diagnostic tool, extensive work is required to optimize the system with variety of known and hidden clinical and pathological parameters. JF - Journal of Clinical Monitoring and Computing AU - Aggarwal, Yogender AU - Karan, Bhuwan Mohan AU - Das, Barda Nand AU - Sinha, Rakesh Kumar Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 425 EP - 30 CY - Dordrecht PB - Springer Science & Business Media VL - 22 IS - 6 SN - 13871307 KW - Medical Sciences--Computer Applications KW - Humans KW - Heat Stress Disorders -- diagnosis KW - Diagnosis, Computer-Assisted -- methods KW - Neural Networks (Computer) KW - Decision Support Systems, Clinical KW - Algorithms KW - Pattern Recognition, Automated -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/217133509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Monitoring+and+Computing&rft.atitle=An+Unsupervised+Neural+Network+to+Predict+the+Level+of+Heat+Stress&rft.au=Aggarwal%2C+Yogender%3BKaran%2C+Bhuwan+Mohan%3BDas%2C+Barda+Nand%3BSinha%2C+Rakesh+Kumar&rft.aulast=Aggarwal&rft.aufirst=Yogender&rft.date=2008-12-01&rft.volume=22&rft.issue=6&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Monitoring+and+Computing&rft.issn=13871307&rft_id=info:doi/10.1007%2Fs10877-008-9152-x LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2009 N1 - Last updated - 2014-08-30 N1 - CODEN - JCMCFG DO - http://dx.doi.org/10.1007/s10877-008-9152-x ER - TY - JOUR T1 - Overview of Recent Studies of Community-Acquired Pneumonia AN - 21433287; 12488324 AB - All recent studies of antibacterial drugs for the indication of community-acquired pneumonia submitted to the US Food and Drug Administration have been designed as noninferiority studies. We provide a summary of results of 7 recent clinical studies of oral antibacterial drugs for treatment of community-acquired pneumonia. In these 7 studies, the majority of patients enrolled had Pneumonia Patient Outcomes Research Team scores of I or II. The percentage of randomized subjects with pathogens identified at baseline ranged from 47% to 76%, and the percentage of subjects with Streptoccocus pneumoniae isolated at baseline ranged from 66% to 20%. The primary end point in these studies was clinical cure, assessed 7-21 days after completion of therapy. Clinical cure rates were >80% in the intent-to-treat populations and >90% in the per-protocol populations. We also briefly summarize the results from several recently submitted clinical studies of intravenously administered antibacterial drugs for treatment of community-acquired pneumonia, in which we found similar results. JF - Clinical Infectious Diseases AU - Higgins, K AU - Singer, M AU - Valappil, T AU - Nambiar, S AU - Lin, D AU - Cox, E AD - US Food and Drug Administration, Center for Drug Evaluation and Research, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA, karen.higgins@fda.hhs.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - S150 EP - S156 VL - 47 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Reviews KW - Pathogens KW - Pneumonia KW - A 01330:Food Microbiology KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21433287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Overview+of+Recent+Studies+of+Community-Acquired+Pneumonia&rft.au=Higgins%2C+K%3BSinger%2C+M%3BValappil%2C+T%3BNambiar%2C+S%3BLin%2C+D%3BCox%2C+E&rft.aulast=Higgins&rft.aufirst=K&rft.date=2008-12-01&rft.volume=47&rft.issue=&rft.spage=S150&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F591397 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Reviews; Pathogens; Pneumonia DO - http://dx.doi.org/10.1086/591397 ER - TY - RPRT T1 - Apprentice Electrician Electrocuted while Wiring an Elevator Disconnect Switch - Massachusetts AN - 20973691; 11069914 AB - On October 23, 2006, a 24-year-old male apprentice electrician was electrocuted by an energized 480-volt, three-phase circuit while permanently wiring a heavy duty disconnect switch for a new elevator. The supply side of the disconnect switch had three energized wires fed into it through the switch's top mechanical lugs. At the time of the incident, the victim had just finished disconnecting the three energized wires from the switch's top mechanical lugs and came in contact with an energized source, either a wire or the switch housing, and was electrocuted. A co-worker noticed a bright flash and, upon investigating the source of the flash, found the victim slumped on the ground of the elevator mechanical room. The co-worker yelled for help and started to attend to the victim. A second co-worker entered the elevator mechanical room and then placed a call for emergency medical services (EMS). Both co-workers administered cardiopulmonary resuscitation (CPR) until the arrival of EMS a few minutes later. The local police and fire departments were also notified and responded to the incident site. EMS transported the victim to a local hospital were the victim was pronounced dead. The Massachusetts FACE Program concluded that to prevent similar occurrences in the future, employers should: Ensure that electrical circuits and equipment are de-energized and that lockout/tagout procedures are implemented and enforced prior to beginning work; In addition, general contractors, when feasible, should: Ensure that elevators are permanently wired during installation. JF - Apprentice Electrician Electrocuted while Wiring an Elevator Disconnect Switch - Massachusetts. [np]. Dec 2008. AU - Anonymous Y1 - 2008/12// PY - 2008 DA - Dec 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Fires KW - USA, Massachusetts KW - police KW - Housing KW - emergency medical services KW - Hospitals KW - H 7000:Fire Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20973691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=A+Model+Observer+for+the+Assessment+of+Display+Temporal+Characteristics&rft.au=Liang%2C+Hongye%3BBadano%2C+Aldo&rft.aulast=Liang&rft.aufirst=Hongye&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Microarray-based assay for the detection of genetic variations of structural genes of West Nile virus AN - 20738743; 8869334 AB - Adaptation through fixation of spontaneous mutations in the viral genome is considered to be one of the important factors that enable recurrent West Nile virus (WNV) outbreaks in the U.S. Genetic variations can alter viral phenotype and virulence, and degrade the performance of diagnostic and screening assays, vaccines, and potential therapeutic agents. A microarray assay was developed and optimized for the simultaneous detection of any nucleotide mutations in the entire structural region of WNV in order to facilitate public health surveillance of genetic variation of WNV. The DNA microarray consists of 263 oligonucleotide probes overlapping at half of their lengths which have been immobilized on an amine-binding glass slide. The assay was validated using 23 WNV isolates from the 2002-2005 U.S. epidemics. Oligonucleotide-based WNV arrays detected unambiguously all mutations in the structural region of each one of the isolates identified previously by sequencing analysis, serving as a rapid and effective approach for the identification of mutations in the WNV genome. JF - Journal of Virological Methods AU - Grinev, A AU - Daniel, S AU - Laassri, M AU - Chumakov, K AU - Chizhikov, V AU - Rios, M AD - Division of Emerging and Transfusion Transmitted Diseases, Rockville, MD 20852, USA, Andriyan.Grinev@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 27 EP - 40 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 154 IS - 1-2 SN - 0166-0934, 0166-0934 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Genomes KW - Epidemics KW - Adaptations KW - DNA probes KW - Genetic diversity KW - DNA microarrays KW - Oligonucleotides KW - Nucleotides KW - Public health KW - Virulence KW - Vaccines KW - Mutation KW - West Nile virus KW - G 07880:Human Genetics KW - V 22300:Methods KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20738743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Microarray-based+assay+for+the+detection+of+genetic+variations+of+structural+genes+of+West+Nile+virus&rft.au=Grinev%2C+A%3BDaniel%2C+S%3BLaassri%2C+M%3BChumakov%2C+K%3BChizhikov%2C+V%3BRios%2C+M&rft.aulast=Grinev&rft.aufirst=A&rft.date=2008-12-01&rft.volume=154&rft.issue=1-2&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2008.09.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Virulence; Genomes; Adaptations; Epidemics; DNA probes; Genetic diversity; Vaccines; Oligonucleotides; DNA microarrays; Mutation; Nucleotides; Public health; West Nile virus DO - http://dx.doi.org/10.1016/j.jviromet.2008.09.015 ER - TY - JOUR T1 - Evaluation of a comprehensive slip, trip and fall prevention programme for hospital employees AN - 20694750; 10271014 AB - In 2007, the Bureau of Labor Statistics reported that the incidence rate of lost workday injuries from slips, trips and falls (STFs) on the same level in hospitals was 35.2 per 10,000 full-time equivalents (FTE), which was 75% greater than the average rate for all other private industries combined (20.2 per 10,000 FTEs). The objectives of this 10-year (1996-2005) longitudinal study were to: 1) describe occupational STF injury events in hospitals; 2) evaluate the effectiveness of a comprehensive programme for reducing STF incidents among hospital employees. The comprehensive prevention programme included analysis of injury records to identify common causes of STFs, on-site hazard assessments, changes to housekeeping procedures and products, introduction of STF preventive products and procedures, general awareness campaigns, programmes for external ice and snow removal, flooring changes and slip-resistant footwear for certain employee subgroups. The hospitals' total STF workers' compensation claims rate declined by 58% from the pre-intervention (1996-1999) rate of 1.66 claims per 100 FTE to the post-intervention (2003-2005) time period rate of 0.76 claims per 100 FTE (adjusted rate ratio = 0.42, 95% CI: 0.33-0.54). STFs due to liquid contamination (water, fluid, slippery, greasy and slick spots) were the most common cause (24%) of STF claims for the entire study period 1996-2005. Food services, transport/emergency medical service and housekeeping staff were at highest risk of a STF claim in the hospital environment. Nursing and office administrative staff generated the largest numbers of STF claims. STF injury events in hospitals have a myriad of causes and the work conditions in hospitals are diverse. This research provides evidence that implementation of a broad-scale prevention programme can significantly reduce STF injury claims. JF - Ergonomics AU - Bell, Jennifer AU - Collins, James AU - Wolf, Laurie AU - Gronqvist, Raoul AU - Chiou, Sharon AU - Chang, Wen-Ruey AU - Sorock, Gary AU - Courtney, Theodore AU - Lombardi, David AU - Evanoff, Bradley AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1906 EP - 1925 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 51 IS - 12 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Injuries KW - Occupational safety KW - prevention KW - Ergonomics KW - workers' compensation KW - Ice KW - Falls KW - Snow KW - longitudinal studies KW - emergency medical services KW - Hospitals KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20694750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Evaluation+of+a+comprehensive+slip%2C+trip+and+fall+prevention+programme+for+hospital+employees&rft.au=Bell%2C+Jennifer%3BCollins%2C+James%3BWolf%2C+Laurie%3BGronqvist%2C+Raoul%3BChiou%2C+Sharon%3BChang%2C+Wen-Ruey%3BSorock%2C+Gary%3BCourtney%2C+Theodore%3BLombardi%2C+David%3BEvanoff%2C+Bradley&rft.aulast=Bell&rft.aufirst=Jennifer&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=1906&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130802248092 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Hospitals; Injuries; Falls; Occupational safety; prevention; emergency medical services; Ice; longitudinal studies; Ergonomics; Snow; workers' compensation DO - http://dx.doi.org/10.1080/00140130802248092 ER - TY - JOUR T1 - Footwear effects on walking balance at elevation AN - 20694714; 10271013 AB - The study evaluated the effects of shoe style on workers' instability during walking at elevation. Twenty-four construction workers performed walking tasks on roof planks in a surround-screen virtual reality system, which simulated a residential roof environment. Three common athletic and three work shoe styles were tested on wide, narrow and tilted planks on a simulated roof and on an unrestricted surface at simulated ground. Dependent variables included lateral angular velocities of the trunk and the rear foot, as well as the workers' rated perceptions of instability. The results demonstrated that shoe style significantly affected workers walking instability at elevated work environments. The results highlighted two major shoe-design pathways for improving walking balance at elevation: enhancing rear foot motion control; and improving ankle proprioception. This study also outlined some of the challenges in optimal shoe selection and specific shoe-design needs for improved walking stability during roof work. The study adds to the knowledge in the area of balance control, by emphasising the role of footwear as a critical human-support surface interface during work on narrow surfaces at height. The results can be used for footwear selection and improvements to reduce risk of falls from elevation. JF - Ergonomics AU - Simeonov, Peter AU - Hsiao, Hongwei AU - Powers, John AU - Ammons, Douglas AU - Amendola, Alfred AU - Kau, Tsui-Ying AU - Cantis, Douglas AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1885 EP - 1905 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 51 IS - 12 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Risk reduction KW - working conditions KW - risk reduction KW - Construction industry KW - Ergonomics KW - Working conditions KW - Perception KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20694714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Footwear+effects+on+walking+balance+at+elevation&rft.au=Simeonov%2C+Peter%3BHsiao%2C+Hongwei%3BPowers%2C+John%3BAmmons%2C+Douglas%3BAmendola%2C+Alfred%3BKau%2C+Tsui-Ying%3BCantis%2C+Douglas&rft.aulast=Simeonov&rft.aufirst=Peter&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=1885&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130802562625 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Risk reduction; Occupational health; Ergonomics; Working conditions; Perception; Construction industry; risk reduction; working conditions DO - http://dx.doi.org/10.1080/00140130802562625 ER - TY - JOUR T1 - Record-linkage and capture-recapture analysis to estimate the incidence and completeness of reporting of tuberculosis in England 1999-2002 AN - 20594339; 9293886 AB - In 1999 the Enhanced Tuberculosis Surveillance (ETS) system was introduced in the United Kingdom to strengthen surveillance of tuberculosis (TB). The aim of this study was to assess the use of record-linkage and capture-recapture methodology for estimating the completeness of TB reporting in England between 1999 and 2002. Due to the size of the TB data sources sophisticated record-linkage software was required and the proportion of false-positive cases among unlinked hospital-derived TB records was estimated through a population mixture model. This study showed that record-linkage of TB data sources and cross-validation with additional TB-related datasets improved data quality as well as case ascertainment. Since the introduction of ETS observed completeness of notification in England has increased and the results were consistent with expected levels of under-notification. Completeness of notification estimated by a log-linear capture-recapture model was highly inconsistent with prior estimates and the validity of this methodology was further examined. JF - Epidemiology and Infection AU - VAN HEST, NAH AU - Story, A AU - Grant, Ad AU - Antoine, D AU - Crofts, J P AU - Watson, J M AD - Tuberculosis Control Section, Division of Infectious Disease Control, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands, vanhestr@ggd.rotterdam.nl Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1606 EP - 1616 PB - Cambridge University Press, The Edinburgh Building, VL - 136 IS - 12 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology KW - Computer programs KW - software KW - Data processing KW - Mycobacterium KW - Tuberculosis KW - Models KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20594339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Record-linkage+and+capture-recapture+analysis+to+estimate+the+incidence+and+completeness+of+reporting+of+tuberculosis+in+England+1999-2002&rft.au=VAN+HEST%2C+NAH%3BStory%2C+A%3BGrant%2C+Ad%3BAntoine%2C+D%3BCrofts%2C+J+P%3BWatson%2C+J+M&rft.aulast=VAN+HEST&rft.aufirst=NAH&rft.date=2008-12-01&rft.volume=136&rft.issue=12&rft.spage=1606&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268808000496 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Data processing; Tuberculosis; Models; Mycobacterium DO - http://dx.doi.org/10.1017/S0950268808000496 ER - TY - JOUR T1 - Adaptive stretch-shortening contractions: diminished regenerative capacity with aging AN - 20575317; 9280115 AB - This study determined the age-related changes in acute events responsible for initiating skeletal muscle remodeling and (or) regeneration in the tibialis anterior muscle following a bout of stretch-shortening contractions (SSCs). Changes in muscle performance and morphology were quantified in young and old rats, following an acute exposure to adaptive SSCs at 6, 24, 48, 72, and 120 h postexposure (n = 6 for each age at each recovery period). Following SSC exposure, all performance measures were decreased in old rats throughout the 120 h acute phase. Estimates of edema were increased in the old vs. young exposed muscle at 120 h recovery. Both young and old rats displayed an increase in developmental myosin heavy chain (MHC sub(dev) super(+)) labeling in the exposed muscle, indicating muscle regeneration. However, old rats displayed diminished MHC sub(dev) super(+) labeling, compared with young rats, suggesting limited remodeling and (or) regenerative capacity. Based on these data, diminished local muscle remodeling and (or) regeneration with aging may limit skeletal muscle adaptation following mechanical loading.Original Abstract: Cette etude se propose de determiner les evenements immediats qui sont associes au vieillissement et qui declenchent le remodelage et (ou) regeneration du muscle jambier anterieur apres une serie d'actions d'etirement-contraction (SSCs). On evalue chez des rats jeunes et ages les variations de performance musculaire et les modifications morphologiques observees 6, h, 24 h, 48 h, 72 h et 120 h apres les breves expositions aux SSCs a caractere adaptatif (n = 6 par groupe d'age et par periode de recuperation). Apres l'exposition au SSCs, on observe durant les 120 h d'adaptation une baisse de performance chez les rats ages. D'apres des estimations, le degre de l'[oeligdeme observe 120 h apres l'exposition aux SSCs est plus prononce chez les rats ages que chez les jeunes rats. On observe tant chez les jeunes rats que chez les plus ages une augmentation du marquage de la chaine lourde de myosine en croissance (MHC sub(dev) super(+)), signe de regeneration musculaire. Cependant, on observe moins de marquage de la MHC sub(dev) super(+) chez les rats ages comparativement aux jeunes rats, ce qui suggere une diminution de la capacite de remodelage et (ou) regeneration chez ces premiers. D'apres ces observations, la diminution de la capacite de remodelage et (ou) regeneration observee avec le vieillissement semble limiter l'adaptation du muscle au chargement mecanique. JF - Applied Physiology, Nutrition, and Metabolism AU - Baker, Brent A AU - Hollander, Melinda S AU - Mercer, Robert R AU - Kashon, Michael L AU - Cutlip, Robert G AD - National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division, Morgantown, WV 26505, USA., rgc8@cdc.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1181 EP - 1191 PB - NRC Research Press VL - 33 IS - 6 SN - 1715-5312, 1715-5312 KW - Physical Education Index KW - aging KW - muscle regeneration KW - inflammation KW - myosin heavy chain KW - stretch-shortening contractions KW - vieillissement KW - regeneration musculaire KW - chaine lourde de myosine KW - actions d'etirement-contraction KW - Muscles (function) KW - Recovery KW - Animal subjects KW - Muscles KW - Edema KW - Performance KW - Muscles (contractions) KW - Nutrition KW - Youth KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20575317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=Comparisons+of+Two+Agreement+Measures&rft.au=Liu%2C+Weimin%3BGallas%2C+Brandon+D&rft.aulast=Liu&rft.aufirst=Weimin&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Muscles (function); Recovery; Animal subjects; Muscles; Edema; Performance; Muscles (contractions); Nutrition; Youth DO - http://dx.doi.org/10.1139/H08-110 ER - TY - JOUR T1 - Statistical Application and Challenges in Global Gel-Free Proteomic Analysis by Mass Spectrometry AN - 20531755; 9218323 AB - Global gel-free proteomic analysis by mass spectrometry has been widely used as an important tool for exploring complex biological systems at the whole genome level. Simultaneous analysis of a large number of protein species is a complicated and challenging task. The challenges exist throughout all stages of a global gel-free proteomic analysis: experimental design, peptide/protein identification, data preprocessing and normalization, and inferential analysis. In addition to various efforts to improve the analytical technologies, statistical methodologies have been applied in all stages of proteomic analyses to help extract relevant information efficiently from large proteomic datasets. In this review, we summarize current applications of statistics in several stages of global gel-free proteomic analysis by mass spectrometry. We discuss the challenges associated with the applications of various statistical tools. Whenever possible, we also propose potential solutions on how to improve the data collection and interpretation for mass-spectrometry-based global proteomic analysis using more sophisticated and/or novel statistical approaches. JF - Critical Reviews in Biotechnology AU - Nie, Lei AU - Wu, Gang AU - Zhang, Weiwen AD - Division of Biometrics IV, Office of Biometrics/CDER/OTS/FDA, Spring, MD, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 297 EP - 307 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 28 IS - 4 SN - 0738-8551, 0738-8551 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Statistics KW - Data processing KW - Information processing KW - Reviews KW - Statistical analysis KW - proteomics KW - Data collections KW - Mass spectroscopy KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20531755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Biotechnology&rft.atitle=Statistical+Application+and+Challenges+in+Global+Gel-Free+Proteomic+Analysis+by+Mass+Spectrometry&rft.au=Nie%2C+Lei%3BWu%2C+Gang%3BZhang%2C+Weiwen&rft.aulast=Nie&rft.aufirst=Lei&rft.date=2008-12-01&rft.volume=28&rft.issue=4&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Critical+Reviews+in+Biotechnology&rft.issn=07388551&rft_id=info:doi/10.1080%2F07388550802543158 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; Statistics; Reviews; Information processing; Statistical analysis; Data collections; proteomics; Mass spectroscopy DO - http://dx.doi.org/10.1080/07388550802543158 ER - TY - JOUR T1 - Utility of Adaptive Strategy and Adaptive Design for Biomarker-facilitated Patient Selection in Pharmacogenomic or Pharmacogenetic Clinical Development Program AN - 20367575; 9048861 AB - In the early to late phases of conventional clinical trials, improvement of disease status at study baseline is the anchor of an effective treatment measured by therapeutic response. These population-based clinical trials do not formally account for disease-associated marker genotype or genome-associated therapeutic response. We discuss alternative study designs in pharmacogenomic or pharmacogenetic clinical trials for genomic or genetic biomarker development, and for formally assessing the clinical utility of genomic or genetic (composite) biomarkers. A two-stage adaptive strategy from completed, ongoing or prospectively planned pharmacogenomic or pharmacogenetic clinical trials is described for development of a genomic or genetic biomarker. We present two types of adaptive design: (1) the genomic biomarker is developed external to the clinical trial, which is designed for treatment effect inference; and (2) first-stage data are used to explore a genomic biomarker, but statistical inference of treatment effect in the genomically or genetically defined biomarker subset is only performed at the second stage of the same trial. When the null hypothesis of no treatment effect in all randomized patients and the genomic patient subset are prospectively specified, we compare the statistical power between fixed and adaptive designs. We also compare the two types of adaptive design. Results from simulation studies showed that adaptive design is more powerful than fixed design for those genomic or genetic biomarkers whose clinical utility is predictive of treatment effect. Pursuit of adaptive design gains at least 20% to more than 30% genomic patient subset power when the genomic biomarker status is readily usable at study initiation, in comparison to when it is explored using the first-stage data of the same clinical trial. In exploratory studies, adaptive strategy provides wide flexibility in the process of genomic or genetic biomarker development. In contrast, an adaptive design trial that employs limited flexibility, and is an adequate and well-controlled investigation, has a greater power gain than a fixed design trial, in which the genomic biomarker is capable of predicting treatment effects that pertain only to the prespecified genomic or genetic patient subset. JF - Journal of the Formosan Medical Association AU - Wang, S-J AD - Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, US FDA, HFD-700, WO 21, Mail Stop Room 3562, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA, suejane.wang@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - S19 EP - S27 VL - 107 IS - 12 SN - 0929-6646, 0929-6646 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Statistics KW - pharmacogenomics KW - genomics KW - Genotypes KW - biomarkers KW - Clinical trials KW - Pharmacogenetics KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20367575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Formosan+Medical+Association&rft.atitle=Utility+of+Adaptive+Strategy+and+Adaptive+Design+for+Biomarker-facilitated+Patient+Selection+in+Pharmacogenomic+or+Pharmacogenetic+Clinical+Development+Program&rft.au=Wang%2C+S-J&rft.aulast=Wang&rft.aufirst=S-J&rft.date=2008-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Statistics; Data processing; pharmacogenomics; Genotypes; genomics; Clinical trials; biomarkers; Pharmacogenetics ER - TY - JOUR T1 - AN ANTIBODY MODIFIED AUTOMATED ENZYME-LINKED IMMUNOSORBENT ASSAY-BASED METHOD FOR DETECTION OF STAPHYLOCOCCAL ENTEROTOXIN* AN - 20303004; 8910407 AB - ABSTRACTStudies were conducted with an automated enzyme-linked immunosorbent assay (ELISA)-based method (Vidas, Staph enterotoxin-II [SET-II]), exhibiting an antibody capture that had undergone modification by removal of the Fc fragment on the antibody. Raw liquid or shell eggs containing a nontoxin component with an attraction to the staphylococcal antienterotoxins were studied. Prior to ELISA testing, the eggs were homogenized and extracts collected by centrifugation. Studies showed that regardless of the ELISA-based method used that utilized the unmodified antibodies with both the Fab1+Fc fragments intact, positive (false positive) ELISA responses occurred with fertilized egg yolks and fertilized whole liquid or whole shell eggs. Conversely, when modified (Fab1) antibodies were used, the automated SET-II enzyme-linked fluorescent immunoassay was negative.PRACTICAL APPLICATIONSMost enzyme-linked immunosorbent assays as well as other serological systems use the whole antibody that has not undergone modification for the detection of the staphylococcal enterotoxins. The use of whole antibody (Fab1+Fc fragments) has on occasion produced false positive results. However, the antibody in which the Fc fragment has been removed leaving the Fab1 fragment provides a more specific antibody for the identification of this microbial toxin. The use of modified antibody (Fab1 fragment) represents significant improvement in antibody quality thus ensuring a greater degree of specificity without sacrificing the sensitivity of serological methods for the detection of staphylococcal enterotoxin in foods. JF - Journal of Rapid Methods and Automation in Microbiology AU - Bennett, Reginald W AD - Food and Drug Administration5100 Paint Branch ParkwayCollege Park, MD 20740-3835 Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 320 EP - 329 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 16 SN - 1060-3999, 1060-3999 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Fc KW - Centrifugation KW - Antibodies KW - Enzyme-linked immunosorbent assay KW - Food KW - Automation KW - Shells KW - Eggs KW - Immunosorbents KW - Toxins KW - Yolk KW - A 01490:Miscellaneous KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20303004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rapid+Methods+and+Automation+in+Microbiology&rft.atitle=AN+ANTIBODY+MODIFIED+AUTOMATED+ENZYME-LINKED+IMMUNOSORBENT+ASSAY-BASED+METHOD+FOR+DETECTION+OF+STAPHYLOCOCCAL+ENTEROTOXIN*&rft.au=Bennett%2C+Reginald+W&rft.aulast=Bennett&rft.aufirst=Reginald&rft.date=2008-12-01&rft.volume=16&rft.issue=&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rapid+Methods+and+Automation+in+Microbiology&rft.issn=10603999&rft_id=info:doi/10.1111%2Fj.1745-4581.2008.00138.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Centrifugation; Fc; Enzyme-linked immunosorbent assay; Antibodies; Food; Automation; Shells; Toxins; Immunosorbents; Eggs; Yolk DO - http://dx.doi.org/10.1111/j.1745-4581.2008.00138.x ER - TY - JOUR T1 - Equivalence-by-Design: Targeting In Vivo Drug Delivery Profile AN - 20282440; 8929508 AB - Abstract In the United States (U.S.), drug products are considered therapeutically equivalent if they meet regulatory criteria of pharmaceutical equivalence and bioequivalence. These requirements can be traced back to 1977 when the U.S. Food and Drug Administration (FDA) published the regulations on bioavailability and bioequivalence. Over the years, to keep up with the advancement in science and technology, the FDA has been constantly updating the regulatory approaches to assessing and ensuring equivalence. In view of the recent growth in novel pharmaceutical dosage forms and delivery systems, this paper examines the current framework for documentation of therapeutic equivalence and explores the opportunities of further advancing equivalence methods for complex drug products. It is proposed that equivalence may be established by matching the in vivo drug delivery profile (iDDP) between drug products in comparison. This can be achieved by characterizing the iDDP of the reference formulation with application of an equivalence-by-design approach for pharmaceutical development. Critical variables can be identified to serve as in vitro markers or biomarkers for mapping the desired drug delivery profile in vivo. A multidisciplinary approach may be necessary to develop these markers for characterization of iDDPs. JF - Pharmaceutical Research AU - Chen, Mei-Ling AU - Lee, Vincent HL AD - Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland, 20993-0002, USA, meiling.chen@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2723 EP - 2730 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 25 IS - 12 SN - 0724-8741, 0724-8741 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Bioavailability KW - Pharmaceuticals KW - Mapping KW - biomarkers KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20282440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+Research&rft.atitle=Equivalence-by-Design%3A+Targeting+In+Vivo+Drug+Delivery+Profile&rft.au=Chen%2C+Mei-Ling%3BLee%2C+Vincent+HL&rft.aulast=Chen&rft.aufirst=Mei-Ling&rft.date=2008-12-01&rft.volume=25&rft.issue=12&rft.spage=2723&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+Research&rft.issn=07248741&rft_id=info:doi/10.1007%2Fs11095-008-9743-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bioavailability; Drug delivery; Pharmaceuticals; Mapping; biomarkers DO - http://dx.doi.org/10.1007/s11095-008-9743-8 ER - TY - JOUR T1 - 10th Anniversary Critical Review: Naturally occurring asbestos AN - 20254787; 8879256 AB - Asbestos is a naturally occurring mineral in the Earth's crust, and it is not confined to the historic and current asbestos mining areas, but rather quite commonly encountered in certain geological environments across the world. That diseases developed as a result of high exposures suffered by miners and asbestos products workers is incontrovertible. In addition, asbestos contamination as a result of past production and use is considered a serious issue where remediation is normally required. However, the risk to health of living on soil and rock where asbestos is encountered as a result of the natural occurrence of small quantities of asbestos minerals is less obvious. The picture becomes even less clear when the minerals are subject to intensive investigation, since our generally accepted definitions of asbestos are themselves put to the test. The discovery of asbestos or related minerals has consequences beyond any immediate risks to health, including profound effects on the value of and ability to use or enjoy property. This review examines the issue of naturally occurring asbestos (NOA) as it has developed in the United States of America and elsewhere, including some superficial insights into the reactions of communities to the presence of NOA. These responses to 'contamination' by nature deserve further in-depth study. JF - Journal of Environmental Monitoring AU - Harper, M AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1394 EP - 1408 VL - 10 IS - 12 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Risk Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Asbestos KW - Bioremediation KW - Occupational safety KW - Earth crust KW - Soil KW - USA KW - Reviews KW - Geology KW - Mining KW - Minerals KW - earth crust KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20254787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=10th+Anniversary+Critical+Review%3A+Naturally+occurring+asbestos&rft.au=Harper%2C+M&rft.aulast=Harper&rft.aufirst=M&rft.date=2008-12-01&rft.volume=10&rft.issue=12&rft.spage=1394&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb810541n LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Soil; Historical account; Asbestos; Bioremediation; Reviews; Occupational safety; Earth crust; Geology; Mining; Minerals; earth crust; USA DO - http://dx.doi.org/10.1039/b810541n ER - TY - JOUR T1 - Sharpening the focus on occupational safety and health in nanotechnology AN - 19922992; 9016296 AB - Increasing numbers of workers are involved with the production, use, distribution, and disposal of nanomaterials. At the same time, there is a growing number of reports of adverse biological effects of engineered nanoparticles in test systems. It is useful, at this juncture, to identify critical questions that will help address knowledge gaps concerning the potential occupational hazards of these materials. The questions address (i) hazard classification of engineered nanoparticles, (ii) exposure metrics, (iii) the actual exposures to the different engineered nanoparticles in the workplace, (iv) the limits of engineering controls and personal protective equipment with respect to engineered nanoparticles, (v) the kinds of surveillance programs that may be required at workplaces to protect potentially exposed workers, (vi) whether exposure registers should be established for workers potentially exposed to engineered nanoparticles, and, (vii) whether engineered nanoparticles should be treated as "new" substances and evaluated for safety and hazards?. JF - Scandinavian Journal of Work, Environment & Health AU - Schulte, P AU - Geraci, C AU - Zumwalde, R AU - Hoover, M AU - Castranova, V AU - Kuempel, E AU - Murashov, V AU - Vainio, H AU - Savolainen, K AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, OH 45226, USA, PSchulte@cdc.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 471 EP - 478 VL - 34 IS - 6 SN - 0355-3140, 0355-3140 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - biological effects KW - Occupational safety KW - Protective equipment KW - Workers KW - safety engineering KW - Classification KW - Occupational hazards KW - nanoparticles KW - Occupational exposure KW - nanotechnology KW - X 24490:Other KW - H 1000:Occupational Safety and Health KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19922992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Sharpening+the+focus+on+occupational+safety+and+health+in+nanotechnology&rft.au=Schulte%2C+P%3BGeraci%2C+C%3BZumwalde%2C+R%3BHoover%2C+M%3BCastranova%2C+V%3BKuempel%2C+E%3BMurashov%2C+V%3BVainio%2C+H%3BSavolainen%2C+K&rft.aulast=Schulte&rft.aufirst=P&rft.date=2008-12-01&rft.volume=34&rft.issue=6&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Workers; Classification; Occupational hazards; nanoparticles; Occupational exposure; nanotechnology; safety engineering; biological effects; Occupational safety; Protective equipment ER - TY - JOUR T1 - A fluorescence detection platform using spatial electroluminescent excitation for measuring botulinum neurotoxin A activity AN - 19892059; 8579451 AB - Current biodetection illumination technologies (laser, LED, tungsten lamp, etc.) are based on spot illumination with additional optics required when spatial excitation is required. Herein we describe a new approach of spatial illumination based on electroluminescence (EL) semiconductor strips available in several wavelengths, greatly simplifying the biosensor design by eliminating the need for additional optics. This work combines EL excitation with charge-coupled device (CCD) based detection (EL-CCD detector) of fluorescence for developing a simple portable detector for botulinum neurotoxin A (BoTN-A) activity analysis. A Forster Resonance Energy Transfer (FRET) activity assay for BoTN-A was used to both characterize and optimize the EL-CCD detector. The system consists of two modules: (1) the detection module which houses the CCD camera and emission filters, and (2) the excitation and sample module, containing the EL strip, the excitation filter and the 9-well sample chip. The FRET activity assay used in this study utilized a FITC/DABCYL-SNAP-25 peptide substrate in which cleavage of the substrate by BoTN-A, or its light chain derivative (LcA), produced an increase in fluorescence emission. EL-CCD detector measured limits of detection (LODs) were similar to those measured using a standard fluorescent plate reader with valves between 0.625 and 1.25nM (31-62ng/ml) for LcA and 0.313nM (45ng/ml) for the full toxin, BoTN-A. As far as the authors are aware this is the first demonstration of phosphor-based EL strips being used for the spatial illumination/excitation of a surface, coupled with CCD for point of care detection. JF - Biosensors and Bioelectronics AU - Sapsford, KE AU - Sun, S AU - Francis, J AU - Sharma, S AU - Kostov, Y AU - Rasooly, A AD - Office of Science and Engineering Laboratories, FDA, Silver Spring, MD 20993, USA, rasoolya@mail.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 618 EP - 625 PB - Elsevier Advanced Technology, 660 White Plains Rd. Tarrytown NY 10591-5153 USA VL - 24 IS - 4 SN - 0956-5663, 0956-5663 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Filters KW - Biosensors KW - Light chains KW - Houses KW - Illumination KW - Cameras KW - fluorescence resonance energy transfer KW - Lasers KW - Botulinum toxin type A KW - Wavelength KW - Tungsten KW - X 24390:Radioactive Materials KW - W 30955:Biosensors KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19892059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=A+fluorescence+detection+platform+using+spatial+electroluminescent+excitation+for+measuring+botulinum+neurotoxin+A+activity&rft.au=Sapsford%2C+KE%3BSun%2C+S%3BFrancis%2C+J%3BSharma%2C+S%3BKostov%2C+Y%3BRasooly%2C+A&rft.aulast=Sapsford&rft.aufirst=KE&rft.date=2008-12-01&rft.volume=24&rft.issue=4&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2008.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Biosensors; Filters; Houses; Light chains; Illumination; Cameras; fluorescence resonance energy transfer; Lasers; Wavelength; Botulinum toxin type A; Tungsten DO - http://dx.doi.org/10.1016/j.bios.2008.06.018 ER - TY - JOUR T1 - Extension-ladder safety: Solutions and knowledge gaps AN - 19812761; 8751239 AB - Falls from ladders are the second leading cause for work-related fatalities in the US construction industry. A significant portion of these incidents occurs at building-construction-and-maintenance worksites during the use of extension ladders. This paper presents the results of a critical literature review related to: (1) risk factors associated with falls from extension ladders, (2) practical engineering solutions that may reduce fall- from-extension-ladder incidents, and (3) questions pertaining to ladder safety that remain unanswered. The review results show that the underlying causes of falls involving extension ladders include the ladder-base slipping out, ladders tipping, workers slipping while on ladders or transitioning from a ladder to a surface at height, and mechanical failures. Some engineering control measures are available in the literature; yet, significant knowledge gaps remain. The knowledge-gap analysis identified four actions needed to advance ladder-safety practice: (1) research on visual indicators to assist in setting up ladders at the correct angle, (2) developing and evaluating measures to ease the transition from a ladder to a surface at heights, (3) integrating ladder accessories into a convertible design to ease the carrying, assembling, and storing of multiple accessories, and thus to encourage safe practices, and (4) developing a graphic-oriented practical guide for safe ladder use, maintenance, and mechanical-flaw detection. Relevance to industry - This paper identified knowledge gaps associated with extension-ladder use for advancing ladder-safety interventions. The development and evaluation of ladder-safety innovations will provide the necessary feedback to ladder manufacturers and ladder-standard-setting bodies for design enhancement and will provide workers practical solutions to reduce injury risks associated with extension-ladder use. JF - International Journal of Industrial Ergonomics AU - Hsiao, H AU - Simeonov, P AU - Pizatella, T AU - Stout, N AU - McDougall, V AU - Weeks, J AD - Protective Technology Branch, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505, USA, hxh4@cdc.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 959 EP - 965 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 38 IS - 11-12 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - intervention KW - Construction industry KW - Ergonomics KW - Mortality KW - Working conditions KW - Maintenance KW - safety engineering KW - Reviews KW - innovations KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19812761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Extension-ladder+safety%3A+Solutions+and+knowledge+gaps&rft.au=Hsiao%2C+H%3BSimeonov%2C+P%3BPizatella%2C+T%3BStout%2C+N%3BMcDougall%2C+V%3BWeeks%2C+J&rft.aulast=Hsiao&rft.aufirst=H&rft.date=2008-12-01&rft.volume=38&rft.issue=11-12&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2008.01.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - safety engineering; Reviews; Mortality; Ergonomics; Maintenance; innovations; Construction industry; Working conditions; intervention; Injuries DO - http://dx.doi.org/10.1016/j.ergon.2008.01.011 ER - TY - JOUR T1 - Examining Associations Between Job Characteristics and Health: Linking Data From the Occupational Information Network (O*NET) to Two U.S. National Health Surveys AN - 19811764; 8902348 AB - Objective: To determine whether the Occupational Information Network (O*NET) database can be used to identify job dimensions to serve as proxy measures for psychosocial factors and select environmental factors, and to determine whether these factors could be linked to national health surveys to examine associations with health risk behaviors and outcomes. Methods: Job characteristics were obtained from O*NET 98. Health outcomes were obtained from two national surveys. Data were linked using Bureau of Census codes. Multiple logistic regression was used to examine associations between O*NET factors and cardiovascular disease, depression, and health risk factors. Results: Seven of nine work organization or psychosocial factors were significantly associated with health risk behaviors in both the National Health and Nutrition Examination Survey III and National Health Interview Survey. Conclusions: This study demonstrates a method for linking independently obtained health and job characteristic data based on occupational code. JF - Journal of Occupational and Environmental Medicine AU - Alterman, T AU - Grosch, J AU - Chen, X AU - Chrislip, D AU - Petersen, M AU - Krieg, E Jr AU - Chung, H AU - Muntaner, C AD - NIOSH (MS-R17), 5555 Ridge Road, Cincinnati, OH 45213, USA, talterman@cdc.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1401 EP - 1413 VL - 50 IS - 12 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - census KW - environmental factors KW - depression KW - Nutrition KW - USA KW - Cardiovascular diseases KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19811764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Examining+Associations+Between+Job+Characteristics+and+Health%3A+Linking+Data+From+the+Occupational+Information+Network+%28O*NET%29+to+Two+U.S.+National+Health+Surveys&rft.au=Alterman%2C+T%3BGrosch%2C+J%3BChen%2C+X%3BChrislip%2C+D%3BPetersen%2C+M%3BKrieg%2C+E+Jr%3BChung%2C+H%3BMuntaner%2C+C&rft.aulast=Alterman&rft.aufirst=T&rft.date=2008-12-01&rft.volume=50&rft.issue=12&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e318188e882 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; census; Nutrition; environmental factors; Cardiovascular diseases; depression DO - http://dx.doi.org/10.1097/JOM.0b013e318188e882 ER - TY - JOUR T1 - Inhibition of Taq polymerase as a method for screening heparin for oversulfated contaminants AN - 19707102; 8599776 AB - Heparin and low molecular heparins are extensively used in the treatment of a wide range of diseases in addition to their classic anticoagulant activity and can be found coating medical devices such as catheters, stents and filters. Early in 2008, a sharp increase in heparin-associated severe adverse events, including over 80 deaths, was linked to the presence of a contaminant identified as hypersulfated chondroitin sulfate (OS-CS). OS-CS is one of several oversulfated glycosaminoglycans (GAGs) of different origins that can potentially cause similar clinical problems underscoring the need to develop robust screening methods for contaminants in existing and future lots of heparin. This study demonstrates that oversulfated GAGs block the activity of Taq polymerase used for real time PCR. Based on this finding we developed a simple, rapid, sensitive and high throughput screening method to detect and quantify oversulfated chondroitin sulfate (OS-CS) and other potential oversulfated contaminants in commercial lots of heparin. This method requires less than 100miliUnits (mU) of heparin as starting material, therefore avoiding the need to lyophilize and concentrate samples, and has a limit of detection of <1ng for all oversulfated GAGs tested. JF - Biomaterials AU - Tami, C AU - Puig, M AU - Reepmeyer, J C AU - Ye, H AU - D'Avignon, DA AU - Buhse, L AU - Verthelyi, D AD - Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drugs Evaluation and Research, Food and Drug Administration, Rockville Pike, Bethesda, MD 20892, United States, daniela.verthelyi@fda.hhs.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 4808 EP - 4814 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 29 IS - 36 SN - 0142-9612, 0142-9612 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Filters KW - Chondroitin sulfate KW - Glycosaminoglycans KW - Anticoagulants KW - Catheters KW - Polymerase chain reaction KW - Contaminants KW - Heparin KW - Coatings KW - W 30920:Tissue Engineering KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19707102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Inhibition+of+Taq+polymerase+as+a+method+for+screening+heparin+for+oversulfated+contaminants&rft.au=Tami%2C+C%3BPuig%2C+M%3BReepmeyer%2C+J+C%3BYe%2C+H%3BD%27Avignon%2C+DA%3BBuhse%2C+L%3BVerthelyi%2C+D&rft.aulast=Tami&rft.aufirst=C&rft.date=2008-12-01&rft.volume=&rft.issue=145&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Vital+and+health+statistics.+Series+2%2C+Data+evaluation+and+methods+research&rft.issn=00832057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Filters; Anticoagulants; Glycosaminoglycans; Chondroitin sulfate; Catheters; Polymerase chain reaction; Contaminants; Heparin; Coatings DO - http://dx.doi.org/10.1016/j.biomaterials.2008.08.024 ER - TY - JOUR T1 - Dissociable roles of medial orbitofrontal cortex in human operant extinction learning AN - 19366660; 8752719 AB - Operant extinction, which features modification of instrumental responses to stimuli following a change in associated reinforcement, is an important form of learning for organisms in dynamic environments. Animal studies have highlighted orbital and medial prefrontal cortex and amygdala as mediators of operant extinction. Yet little is known about the neural mediators of operant extinction learning in humans. Using a novel fMRI paradigm, we report dissociable functional responses in distinct regions of medial orbitofrontal cortex (mOFC) during successful appetitive and aversive based operant extinction. During successful operant extinction, increased activity was observed in frontopolar OFC, while decreased activity was observed in caudal mOFC and rostral anterior cingulate cortex (rACC) relative to both (i) successful control trials where the reinforcement associated with the stimulus does not change; and (ii) successful acquisition trials during initial learning of the stimulus-reinforcement associations. Functional connectivity analysis demonstrated inverse connectivity between frontopolar OFC and both rACC and the amygdala. These data support animal models suggesting the importance of mOFC-amygdala interaction during operant extinction and expand our knowledge of the neural systems in humans. These findings suggest that in humans, frontopolar OFC modulates activity in caudal mOFC, rACC and amygdala during successful operant extinction learning. JF - NeuroImage AU - Finger, Elizabeth C AU - Mitchell, Derek GV AU - Jones, Matthew AU - Blair, RJR AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, Elizabeth.Finger@lhsc.on.ca Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 748 EP - 755 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 43 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Learning KW - Data processing KW - Extinction KW - Operant conditioning KW - Neural networks KW - Functional magnetic resonance imaging KW - Animal models KW - Cortex (cingulate) KW - Reinforcement KW - Amygdala KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Dissociable+roles+of+medial+orbitofrontal+cortex+in+human+operant+extinction+learning&rft.au=Finger%2C+Elizabeth+C%3BMitchell%2C+Derek+GV%3BJones%2C+Matthew%3BBlair%2C+RJR&rft.aulast=Finger&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=43&rft.issue=4&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.08.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Operant conditioning; Extinction; Learning; Cortex (prefrontal); Amygdala; Neural networks; Reinforcement; Cortex (cingulate); Data processing; Animal models; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2008.08.021 ER - TY - JOUR T1 - Metabolomics and biomarker discovery: NMR spectral data of urine and hepatotoxicity by carbon tetrachloride, acetaminophen, and d-galactosamine in rats AN - 1709172379; 15622745 AB - The primary objective of this study was to discover biomarkers which are correlated with hepatotoxicity induced by chemicals using super(1)H NMR spectral data of urine. A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition was proposed for early screening of the hepatotoxicity of CCl sub(4), acetaminophen (AAP), and d-galactosamine (GalN) in rats. The hepatotoxic compounds were expected to induce necrosis in hepatocytes. This was confirmed through blood biochemistry and histopathology. CCl sub(4) (1 ml/kg, po) or GalN (0.8 g/kg, ip) was single administered to Sprague-Dawley (S-D) rats and urine was collected every 24 h. Animals were sacrificed 24 h or 48 h post-dosing. AAP (2 g/kg, po) was administered for 2 days and then the animals were sacrificed 24 h after the last treatment. NMR spectroscopy revealed evidently different clustering between control groups and hepatotoxicant treatment groups in global metabolic profilings as indicated by partial least square (PLS)-discrimination analysis (DA). In targeted profilings, endogenous metabolites of allantoin, citrate, taurine, 2-oxoglutarate, acetate, lactate, phenylacetyl glycine, succinate, phenylacetate, 1-methylnicotinamide, hippurate, and benzoate were selected as putative biomarkers for hepatoxicity by CCl sub(4), AAP, and GalN. Comparison of our rat super(1)H NMR PLS-DA data with histopathological changes suggests that super(1)H NMR urinalysis can be used to predict hepatotoxicity induced by CCl sub(4), AAP, and GalN. JF - Metabolomics AU - Kim, Kyu-Bong AU - Chung, Myeon Woo AU - Um, So Young AU - Oh, Ji Seon AU - Kim, Seon Hwa AU - Na, Mi Ae AU - Oh, Hye Young AU - Cho, Wan-Seob AU - Choi, Ki Hwan AD - Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, 5-Nokbun-dong, Eunpyung-gu, Seoul, 122-704, South Korea, hyokwa@kfda.go.kr Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 377 EP - 392 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 4 IS - 4 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Benzoic acid KW - Hepatocytes KW - Metabolites KW - D-Galactosamine KW - Acetic acid KW - biomarkers KW - hepatotoxicity KW - Taurine KW - Dopamine KW - Urine KW - Magnetic resonance spectroscopy KW - Lactic acid KW - N.M.R. KW - Allantoin KW - Urinalysis KW - metabolomics KW - Acetaminophen KW - Citric acid KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709172379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Metabolomics+and+biomarker+discovery%3A+NMR+spectral+data+of+urine+and+hepatotoxicity+by+carbon+tetrachloride%2C+acetaminophen%2C+and+d-galactosamine+in+rats&rft.au=Kim%2C+Kyu-Bong%3BChung%2C+Myeon+Woo%3BUm%2C+So+Young%3BOh%2C+Ji+Seon%3BKim%2C+Seon+Hwa%3BNa%2C+Mi+Ae%3BOh%2C+Hye+Young%3BCho%2C+Wan-Seob%3BChoi%2C+Ki+Hwan&rft.aulast=Kim&rft.aufirst=Kyu-Bong&rft.date=2008-12-01&rft.volume=4&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-008-0131-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Benzoic acid; Data processing; Hepatocytes; Metabolites; D-Galactosamine; biomarkers; Acetic acid; hepatotoxicity; Taurine; Dopamine; Urine; Magnetic resonance spectroscopy; Lactic acid; N.M.R.; Allantoin; Urinalysis; Acetaminophen; metabolomics; Citric acid DO - http://dx.doi.org/10.1007/s11306-008-0131-5 ER - TY - CPAPER T1 - Quantization Errors in Radiology—Initial Model Observer Results T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41852091; 5060856 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Badano, Aldo Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41852091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=In+Silico+Toxicological+Screening+of+Natural+Products&rft.au=Arvidson%2C+Kirk+B%3BValerio+Jr%2C+Luis+G%3BDiaz%2C+Marilyn%3BChanderbhan%2C+Ronald+F&rft.aulast=Arvidson&rft.aufirst=Kirk&rft.date=2008-02-01&rft.volume=18&rft.issue=2-3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376510701856991 L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Fast, Angle-dependent, Analytical Model of CsI Detector Response for Optimization of 3D Breast Imaging Systems T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41846635; 5061187 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Freed, Melanie AU - Park, Subok AU - Badano, Aldo Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=A+Fast%2C+Angle-dependent%2C+Analytical+Model+of+CsI+Detector+Response+for+Optimization+of+3D+Breast+Imaging+Systems&rft.au=Freed%2C+Melanie%3BPark%2C+Subok%3BBadano%2C+Aldo&rft.aulast=Freed&rft.aufirst=Melanie&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative in Silico Imaging and Biomarker Assessment Using Physical and Computational Phantoms: A Review of New Tools and Methods Available from the NIBIB/CDRH Joint Laboratory for the Assessment of Medical Imaging Systems T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41813348; 5064077 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Badano, Aldo AU - Gavrielides, Marios AU - Kinnard, Lisa AU - Park, Subok AU - Kyprianou, Iacovos AU - Gallas, Brandon Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Bioindicators KW - Reviews KW - Imaging techniques KW - Biomarkers KW - Joints KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41813348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Quantitative+in+Silico+Imaging+and+Biomarker+Assessment+Using+Physical+and+Computational+Phantoms%3A+A+Review+of+New+Tools+and+Methods+Available+from+the+NIBIB%2FCDRH+Joint+Laboratory+for+the+Assessment+of+Medical+Imaging+Systems&rft.au=Badano%2C+Aldo%3BGavrielides%2C+Marios%3BKinnard%2C+Lisa%3BPark%2C+Subok%3BKyprianou%2C+Iacovos%3BGallas%2C+Brandon&rft.aulast=Badano&rft.aufirst=Aldo&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Vascular Motion of Peripheral Arteries in Swine: Toward Predictive Modeling of Clinical Failure Modes T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41806637; 5061575 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Pritchard, William AU - Karanian, John AU - Constante, Edison AU - Chiesa, Oscar AU - Peregoy, Jennifer AU - Esparza, Juan Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Arteries KW - Vascular system KW - Prediction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41806637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Evaluation+of+Vascular+Motion+of+Peripheral+Arteries+in+Swine%3A+Toward+Predictive+Modeling+of+Clinical+Failure+Modes&rft.au=Pritchard%2C+William%3BKaranian%2C+John%3BConstante%2C+Edison%3BChiesa%2C+Oscar%3BPeregoy%2C+Jennifer%3BEsparza%2C+Juan&rft.aulast=Pritchard&rft.aufirst=William&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of X-radiation on Implantable Devices during Multislice CT Scans: Recommendations for Reducing the Risk of Device Malfunctions T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41804379; 5064080 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Kyprianou, Iacovos AU - Badal, Andreu Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Risk reduction KW - Computed tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41804379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Effects+of+X-radiation+on+Implantable+Devices+during+Multislice+CT+Scans%3A+Recommendations+for+Reducing+the+Risk+of+Device+Malfunctions&rft.au=Kyprianou%2C+Iacovos%3BBadal%2C+Andreu&rft.aulast=Kyprianou&rft.aufirst=Iacovos&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A persistent problem with scabies in and outside a nursing home in Amsterdam: indications for resistance to lindane and ivermectin. AN - 69839504; 19040826 AB - An ongoing outbreak of scabies in and outside a nursing home in Amsterdam is described. Despite standard treatment with lindane and ivermectin, many recurrences were observed which suggested resistance to these drugs. After treatment with 5% permethrine, the patients were finally cured. JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin AU - van den Hoek, J A AU - van de Weerd, J A AU - Baayen, T D AU - Molenaar, P M AU - Sonder, G J AU - van Ouwerkerk, I M AU - de Vries, H J AD - Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands. Y1 - 2008/11/27/ PY - 2008 DA - 2008 Nov 27 VL - 13 IS - 48 KW - Insecticides KW - 0 KW - Permethrin KW - 509F88P9SZ KW - Lindane KW - 59NEE7PCAB KW - Ivermectin KW - 70288-86-7 KW - Index Medicus KW - Netherlands -- epidemiology KW - Treatment Failure KW - Insecticides -- administration & dosage KW - Risk Factors KW - Humans KW - Treatment Outcome KW - Nursing Homes -- statistics & numerical data KW - Incidence KW - Drug Resistance KW - Risk Assessment -- methods KW - Population Surveillance KW - Scabies -- prevention & control KW - Ivermectin -- administration & dosage KW - Disease Outbreaks -- prevention & control KW - Permethrin -- administration & dosage KW - Lindane -- administration & dosage KW - Disease Outbreaks -- statistics & numerical data KW - Scabies -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Euro+surveillance+%3A+bulletin+Europeen+sur+les+maladies+transmissibles+%3D+European+communicable+disease+bulletin&rft.atitle=A+persistent+problem+with+scabies+in+and+outside+a+nursing+home+in+Amsterdam%3A+indications+for+resistance+to+lindane+and+ivermectin.&rft.au=van+den+Hoek%2C+J+A%3Bvan+de+Weerd%2C+J+A%3BBaayen%2C+T+D%3BMolenaar%2C+P+M%3BSonder%2C+G+J%3Bvan+Ouwerkerk%2C+I+M%3Bde+Vries%2C+H+J&rft.aulast=van+den+Hoek&rft.aufirst=J&rft.date=2008-11-27&rft.volume=13&rft.issue=48&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Euro+surveillance+%3A+bulletin+Europeen+sur+les+maladies+transmissibles+%3D+European+communicable+disease+bulletin&rft.issn=1560-7917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-27 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical mixtures: evaluation of risk for child-specific exposures in a multi-stressor environment. AN - 69801375; 18353412 AB - Evaluating the health impact from exposure to chemical mixtures is multifaceted. One component is exposure. Exposure, and consequently risk assessment for mixtures and chemicals in general, are often viewed in terms of a given exposure to a given population at a given location over a given time period. However, environmental exposures are present throughout human lifetime. As a result, an evaluation of risk must include the distinctive characteristics related to chemical exposures which will impact risk depending upon the particular life stage where exposure occurs. Risks to offspring may be associated with unique exposures in utero, during infancy, childhood, or adolescent periods. For example, exposure of infants to anthropogenic chemicals via breast milk may be of concern. The Agency for Toxic Substances and Disease Registry's (ATSDR's) approach to evaluating risks associated with exposure to mixtures of chemicals is presented. In addition to the breast milk issues, indoor exposure to combined air pollutants, drinking water contaminants, and soil and dust contaminants are discussed. The difference between a mixture's risk evaluation for children and adults is in the distinct exposure scenarios resulting from variations in behavior, physiology, and/or pharmacokinetics between adults and children rather than in the method for the specific mixtures evaluation per se. JF - Toxicology and applied pharmacology AU - Pohl, H R AU - Abadin, H G AD - Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, Georgia, USA. hrp1@cdc.gov Y1 - 2008/11/15/ PY - 2008 DA - 2008 Nov 15 SP - 116 EP - 125 VL - 233 IS - 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Age Factors KW - Risk Factors KW - Humans KW - Child KW - Hazardous Substances -- pharmacokinetics KW - Environmental Exposure -- adverse effects KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69801375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Chemical+mixtures%3A+evaluation+of+risk+for+child-specific+exposures+in+a+multi-stressor+environment.&rft.au=Pohl%2C+H+R%3BAbadin%2C+H+G&rft.aulast=Pohl&rft.aufirst=H&rft.date=2008-11-15&rft.volume=233&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2008.01.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-12 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Toxicol Appl Pharmacol. 2008 Dec 1;233(2):353; author reply 354 [18692517] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2008.01.015 ER - TY - JOUR T1 - Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo: a novel approach to sensitize prostate cancer to anticancer therapy. AN - 69791093; 19010904 AB - Interleukin-13 (IL-13) receptor alpha2 (IL-13Ralpha2), a high-affinity IL-13 binding subunit and a tumor antigen, is amplified in a variety of human tumor cell lines and tumors in vivo. By cDNA microarray, we have shown that gene transfer of human and rat adrenomedullin (AM) up-regulates IL-13Ralpha2 in a human prostate tumor cell line. Here, we show that IL-13Ralpha2 mRNA and protein are also up-regulated in PC-3 prostate tumor cells by recombinant AM (rAM) and human synthetic AM peptide in a dose-dependent manner in vitro and in vivo in mouse prostate tumor model. The 8- to 10-fold up-regulation of IL-13Ralpha2 by rAM or AM peptide in prostate tumor cells in vitro and in vivo increased their sensitivity to IL-13PE cytotoxin consisting of IL-13 and a truncated form of Pseudomonas exotoxin. Immunodeficient mice with established prostate tumors transfected with AM or treated with AM peptide showed reduction in tumor size by intratumoral administration of IL-13PE in a dose-dependent manner. At the highest dose (three 100 mug/kg/d every alternate day), >70% reduction of tumor size was observed compared with controls (P 6-log inactivation). D-values at 55 to 47.5 degrees C were 15 to 59 s in mango juice and 16 to 105 s in orange juice with z-values of 9.28 and 12.30 degrees C, respectively. These results indicate that current pasteurization parameters used for destroying common foodborne bacterial pathogens are adequate for eliminating F. tularensis in the four foods tested. This study is the first to determine thermal inactivation of F. tularensis in specific foods and will permit comparisons with the thermal inactivation data of other more traditional foodborne pathogens. JF - Journal of food protection AU - Day, J B AU - Trujillo, S AU - Hao, Y Y D AU - Whiting, R C AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-712, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA. james.day@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 2208 EP - 2212 VL - 71 IS - 11 SN - 0362-028X, 0362-028X KW - Index Medicus KW - Infant KW - Malus -- microbiology KW - Consumer Product Safety KW - Humans KW - Infant, Newborn KW - Colony Count, Microbial KW - Fruit KW - Mangifera -- microbiology KW - Citrus sinensis -- microbiology KW - Time Factors KW - Hot Temperature KW - Infant Formula KW - Beverages -- microbiology KW - Food Handling -- methods KW - Food Contamination -- analysis KW - Francisella tularensis -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69850959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Thermal+resistance+of+Francisella+tularensis+in+infant+formula+and+fruit+juices.&rft.au=Day%2C+J+B%3BTrujillo%2C+S%3BHao%2C+Y+Y+D%3BWhiting%2C+R+C&rft.aulast=Day&rft.aufirst=J&rft.date=2008-11-01&rft.volume=71&rft.issue=11&rft.spage=2208&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-02 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. AN - 69825858; 19023402 AB - The major DNA repair pathways operate on damage in double-strand DNA because they use the intact strand as a template after damage removal. Therefore, lesions in transient single-strand stretches of chromosomal DNA are expected to be especially threatening to genome stability. To test this hypothesis, we designed systems in budding yeast that could generate many kilobases of persistent single-strand DNA next to double-strand breaks or uncapped telomeres. The systems allowed controlled restoration to the double-strand state after applying DNA damage. We found that lesions induced by UV-light and methyl methanesulfonate can be tolerated in long single-strand regions and are hypermutagenic. The hypermutability required PCNA monoubiquitination and was largely attributable to translesion synthesis by the error-prone DNA polymerase zeta. In support of multiple lesions in single-strand DNA being a source of hypermutability, analysis of the UV-induced mutants revealed strong strand-specific bias and unexpectedly high frequency of alleles with widely separated multiple mutations scattered over several kilobases. Hypermutability and multiple mutations associated with lesions in transient stretches of long single-strand DNA may be a source of carcinogenesis and provide selective advantage in adaptive evolution. JF - PLoS genetics AU - Yang, Yong AU - Sterling, Joan AU - Storici, Francesca AU - Resnick, Michael A AU - Gordenin, Dmitry A AD - Department of Health and Human Services, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1 VL - 4 IS - 11 KW - DNA, Fungal KW - 0 KW - DNA, Single-Stranded KW - Index Medicus KW - DNA Repair KW - Models, Genetic KW - Ultraviolet Rays -- adverse effects KW - DNA, Fungal -- genetics KW - Genome, Fungal KW - Mutagenesis KW - Saccharomyces cerevisiae -- genetics KW - Telomere -- metabolism KW - Saccharomyces cerevisiae -- metabolism KW - DNA, Single-Stranded -- chemistry KW - DNA Breaks, Double-Stranded -- radiation effects KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69825858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+genetics&rft.atitle=Hypermutability+of+damaged+single-strand+DNA+formed+at+double-strand+breaks+and+uncapped+telomeres+in+yeast+Saccharomyces+cerevisiae.&rft.au=Yang%2C+Yong%3BSterling%2C+Joan%3BStorici%2C+Francesca%3BResnick%2C+Michael+A%3BGordenin%2C+Dmitry+A&rft.aulast=Yang&rft.aufirst=Yong&rft.date=2008-11-01&rft.volume=4&rft.issue=11&rft.spage=e1000264&rft.isbn=&rft.btitle=&rft.title=PLoS+genetics&rft.issn=1553-7404&rft_id=info:doi/10.1371%2Fjournal.pgen.1000264 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-23 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Mol Cell Biol. 2005 Dec;6(12):943-53 [16341080] Genes Dev. 2008 Jan 15;22(2):125-40 [18198332] DNA Repair (Amst). 2006 Feb 3;5(2):258-73 [16310415] J Cell Biol. 2006 Apr 24;173(2):195-206 [16618811] Methods Enzymol. 2006;409:329-45 [16793410] Methods Enzymol. 2006;409:462-76 [16793418] Nat Rev Immunol. 2006 Aug;6(8):573-83 [16868548] EMBO J. 2006 Sep 20;25(18):4316-25 [16957771] Mol Cell Biol. 2006 Oct;26(20):7645-57 [16908537] Annu Rev Genet. 2006;40:209-35 [16805667] Nat Struct Mol Biol. 2007 Mar;14(3):208-14 [17293872] Genetics. 2007 Mar;175(3):1533-7 [17151233] Proc Natl Acad Sci U S A. 2007 May 15;104(20):8403-8 [17485671] Crit Rev Biochem Mol Biol. 2007 Jul-Aug;42(4):247-58 [17687667] Crit Rev Biochem Mol Biol. 2007 Sep-Oct;42(5):313-26 [17917869] Nat Biotechnol. 2001 Aug;19(8):773-6 [11479573] Curr Opin Microbiol. 2001 Oct;4(5):582-5 [11587936] Nucleic Acids Res. 2001 Nov 1;29(21):4414-22 [11691929] Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1437-42 [11818556] Genetics. 2002 Nov;162(3):1063-77 [12454056] DNA Repair (Amst). 2002 Jun 21;1(6):425-35 [12509231] Nat Genet. 2003 Jul;34(3):326-9 [12796780] Nucleic Acids Res. 2003 Aug 1;31(15):4541-52 [12888515] J Cell Sci. 2003 Oct 15;116(Pt 20):4057-65 [12972499] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14994-9 [14630945] J Bacteriol. 1972 Mar;109(3):979-86 [4551759] Mutat Res. 1975 Nov;30(2):209-18 [1107831] Nature. 1979 Aug 2;280(5721):420-3 [223063] Crit Rev Microbiol. 1985;12(2):131-51 [3928261] Cancer Res. 1991 Jun 15;51(12):3075-9 [2039987] Genetics. 1991 Nov;129(3):957-62 [1752431] Genetics. 1995 Jul;140(3):965-72 [7672595] Yeast. 1995 Dec;11(16):1553-73 [8720065] Photochem Photobiol. 1997 Feb;65(2):270-83 [9066304] J Mol Biol. 1999 Jun 25;289(5):1207-18 [10373362] Yeast. 1999 Oct;15(14):1541-53 [10514571] Proc Natl Acad Sci U S A. 1963 Nov;50:975-80 [14082365] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12849-54 [16118275] Biochem Soc Trans. 2007 Nov;35(Pt 5):1334-7 [17956345] DNA Repair (Amst). 2007 Dec 1;6(12):1829-38 [17715002] Nature. 2007 Nov 22;450(7169):509-14 [17965729] Mol Cell. 2007 Dec 14;28(5):739-45 [18082599] Mol Cell. 2006 Jan 6;21(1):15-27 [16387650] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pgen.1000264 ER - TY - JOUR T1 - Intracranial hemorrhage and liver-associated deaths associated with tipranavir/ritonavir: review of cases from the FDA's Adverse Event Reporting System. AN - 69820230; 19025478 AB - Tipranavir (TPV), a protease inhibitor, has box warnings for intracranial hemorrhage (ICH) and hepatotoxicity (including hepatic failure and death). A box warning is a labeling statement about serious adverse events leading to significant injury and/or death. A box warning is the most serious warning placed in the labeling of a prescription medication. As a result of the respective morbidity and mortality associated with ICH and hepatic failure, the Food and Drug Administration's (FDA's) Adverse Event Reporting System (AERS) was searched for reports of these adverse events in HIV-infected patients receiving a tipranavir/ritonavir (TPV/r)-based regimen. This search comprised part of the FDA's safety analysis for traditional approval. From July 2006 to March 2007, 10 cases of ICH were identified in AERS. From June 2005 to March 2007, 12 cases of liver-associated deaths were identified. One patient experienced liver failure and fatal ICH. Most patients with these events had additional risk factors. Among patients with liver-associated deaths, 3 had HIV-RNA less than 400 copies per milliliter at the time of hepatic failure. Among 10 patients who discontinued TPV/r when hepatic failure developed, median number of days post-TPV/r to death was 23 (range, 2-69 days). Review of AERS did not identify new safety concerns regarding ICH. Among most patients with liver-associated deaths, death appears to occur soon after hepatic failure develops. If considering TPV/r, careful assessment of risk/benefit is suggested for patients at risk for ICH and hepatic failure. JF - AIDS patient care and STDs AU - Chan-Tack, Kirk M AU - Struble, Kimberly A AU - Birnkrant, Debra B AD - Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA. kirk.chan-tack@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 843 EP - 850 VL - 22 IS - 11 KW - HIV Protease Inhibitors KW - 0 KW - Pyridines KW - Pyrones KW - Ritonavir KW - O3J8G9O825 KW - tipranavir KW - ZZT404XD09 KW - Index Medicus KW - AIDS/HIV KW - Drug Therapy, Combination KW - United States Food and Drug Administration KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - HIV-1 -- drug effects KW - Male KW - Female KW - HIV Infections -- virology KW - Liver Failure -- mortality KW - Intracranial Hemorrhages -- epidemiology KW - Liver Failure -- epidemiology KW - Intracranial Hemorrhages -- mortality KW - Intracranial Hemorrhages -- chemically induced KW - HIV Infections -- drug therapy KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Liver Failure -- chemically induced KW - Pyrones -- adverse effects KW - HIV Protease Inhibitors -- adverse effects KW - Ritonavir -- adverse effects KW - Pyridines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69820230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Herbal+product+use+by+persons+enrolled+in+the+hepatitis+C+Antiviral+Long-Term+Treatment+Against+Cirrhosis+%28HALT-C%29+Trial.&rft.au=Seeff%2C+Leonard+B%3BCurto%2C+Teresa+M%3BSzabo%2C+Gyongyi%3BEverson%2C+Gregory+T%3BBonkovsky%2C+Herbert+L%3BDienstag%2C+Jules+L%3BShiffman%2C+Mitchell+L%3BLindsay%2C+Karen+L%3BLok%2C+Anna+S+F%3BDi+Bisceglie%2C+Adrian+M%3BLee%2C+William+M%3BGhany%2C+Marc+G%3BHALT-C+Trial+Group&rft.aulast=Seeff&rft.aufirst=Leonard&rft.date=2008-02-01&rft.volume=47&rft.issue=2&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-30 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/apc.2008.0043 ER - TY - JOUR T1 - Determination of dialkyl phosphate metabolites of organophosphorus pesticides in human urine by automated solid-phase extraction, derivatization, and gas chromatography-mass spectrometry. AN - 69814810; 19021926 AB - Organophosphorus (OP) pesticides are highly toxic but used commonly worldwide, nevertheless. Their urinary dialkylphosphate (DAP) metabolites are widely used for exposure assessment of OP pesticides in humans. We previously developed an analytical method to measure urinary DAPs utilizing solid-phase extraction (SPE)-derivatization-gas chromatography-tandem mass spectrometry (GC-MS-MS) with quantification using isotope-dilution technique. We now present a more cost-effective yet highly accurate method that can be easily adaptable to many laboratories for routine OP exposure assessment. This method is simple and fast and involves automated SPE of the metabolites followed by derivatization with pentafluorobenzyl bromide and quantification by GC-MS. Dibutyl phosphate (DBP) serves as the internal standard. The detection limits for the six metabolites ranged from 0.1 to 0.15 ng/mL. Depending on the metabolite the relative standard deviation of the analytical procedure was 2-15% for the metabolites. We compared performance of DBP as an internal standard with that of isotope-labeled compounds and found that DBP gives reliable results for the analytical procedure. We also optimized reaction parameters of pentafluorobenzylation. JF - Journal of analytical toxicology AU - Hemakanthi De Alwis, G K AU - Needham, Larry L AU - Barr, Dana B AD - Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F 17, Atlanta, Georgia 30341, USA. hemakanthi.dealwis@fda.hhs.gov PY - 2008 SP - 721 EP - 727 VL - 32 IS - 9 SN - 0146-4760, 0146-4760 KW - Insecticides KW - 0 KW - Organophosphates KW - Solvents KW - di-n-butylphosphoric acid KW - 107-66-4 KW - Index Medicus KW - Reproducibility of Results KW - Biotransformation KW - Humans KW - Reference Standards KW - Temperature KW - Gas Chromatography-Mass Spectrometry KW - Automation KW - Organophosphates -- urine KW - Insecticides -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69814810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Determination+of+dialkyl+phosphate+metabolites+of+organophosphorus+pesticides+in+human+urine+by+automated+solid-phase+extraction%2C+derivatization%2C+and+gas+chromatography-mass+spectrometry.&rft.au=Hemakanthi+De+Alwis%2C+G+K%3BNeedham%2C+Larry+L%3BBarr%2C+Dana+B&rft.aulast=Hemakanthi+De+Alwis&rft.aufirst=G&rft.date=2008-11-01&rft.volume=32&rft.issue=9&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-06 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The US must help set international standards for nanotechnology. AN - 69766017; 18989319 JF - Nature nanotechnology AU - Murashov, Vladimir AU - Howard, John AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US Department of Health and Human Services, Washington, DC 20201, USA. vladimir.murashov@cdc.hhs.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 635 EP - 636 VL - 3 IS - 11 KW - Index Medicus KW - United States KW - Guideline Adherence -- organization & administration KW - International Agencies -- legislation & jurisprudence KW - Nanostructures -- standards KW - Nanostructures -- adverse effects KW - Humans KW - Reference Standards KW - International Agencies -- organization & administration KW - Guideline Adherence -- legislation & jurisprudence KW - International Cooperation -- legislation & jurisprudence KW - Government Regulation KW - Nanotechnology -- legislation & jurisprudence KW - Risk Management -- trends KW - Nanotechnology -- standards KW - Risk Management -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69766017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+nanotechnology&rft.atitle=The+US+must+help+set+international+standards+for+nanotechnology.&rft.au=Murashov%2C+Vladimir%3BHoward%2C+John&rft.aulast=Murashov&rft.aufirst=Vladimir&rft.date=2008-11-01&rft.volume=25&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2007.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nat Nanotechnol. 2009 Apr;4(4):205; author reply 205-6 [19350019] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nnano.2008.323 ER - TY - JOUR T1 - Role of the N-terminal amino acid of Bacillus anthracis lethal factor in lethal toxin cytotoxicity and its effect on the lethal toxin neutralization assay. AN - 69749996; 18815235 AB - The cytotoxic activity of lethal factor (LF), a critical reagent used in the cell-based lethal toxin neutralization assay to assess anthrax vaccines, was shown to depend on the identity of its N-terminal amino acid, which plays a role in the targeting of LF to the proteasome for degradation. These results demonstrate that care must be taken to ensure that LF preparations used in standardized cell-based assays are not altered at their N-terminal ends. JF - Clinical and vaccine immunology : CVI AU - Verma, Anita AU - Wagner, Leslie AU - Stibitz, Scott AU - Nguyen, Nga AU - Guerengomba, Flor AU - Burns, Drusilla L AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1737 EP - 1741 VL - 15 IS - 11 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - anthrax toxin KW - Index Medicus KW - Animals KW - Neutralization Tests KW - Mice KW - Amino Acid Sequence KW - Cell Line KW - Amino Acid Substitution KW - Bacterial Toxins -- genetics KW - Antigens, Bacterial -- toxicity KW - Bacterial Toxins -- toxicity KW - Macrophages -- drug effects KW - Antigens, Bacterial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69749996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+vaccine+immunology+%3A+CVI&rft.atitle=Role+of+the+N-terminal+amino+acid+of+Bacillus+anthracis+lethal+factor+in+lethal+toxin+cytotoxicity+and+its+effect+on+the+lethal+toxin+neutralization+assay.&rft.au=Verma%2C+Anita%3BWagner%2C+Leslie%3BStibitz%2C+Scott%3BNguyen%2C+Nga%3BGuerengomba%2C+Flor%3BBurns%2C+Drusilla+L&rft.aulast=Verma&rft.aufirst=Anita&rft.date=2008-11-01&rft.volume=15&rft.issue=11&rft.spage=1737&rft.isbn=&rft.btitle=&rft.title=Clinical+and+vaccine+immunology+%3A+CVI&rft.issn=1556-679X&rft_id=info:doi/10.1128%2FCVI.00081-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-01 N1 - Date created - 2008-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 2000 Apr;68(4):1781-6 [10722564] Infect Immun. 2007 Nov;75(11):5135-47 [17682039] Vaccine. 2001 Sep 14;19(32):4768-73 [11535328] Vaccine. 2004 Jan 2;22(3-4):422-30 [14670324] Biologicals. 2004 Mar;32(1):17-27 [15026022] J Infect Dis. 2004 Oct 1;190(7):1228-36 [15346332] Science. 1986 Oct 10;234(4773):179-86 [3018930] Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12142-9 [8901547] Infect Immun. 1998 Feb;66(2):862-5 [9453657] Science. 1998 May 1;280(5364):734-7 [9563949] Biochem Biophys Res Commun. 1998 Jul 30;248(3):706-11 [9703991] Biochemistry. 1998 Nov 10;37(45):15737-46 [9843379] Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16756-61 [15548616] J Bacteriol. 2005 May;187(9):3133-8 [15838040] Vaccine. 2006 Aug 14;24(33-34):5950-9 [16797805] Hum Vaccin. 2007 Sep-Oct;3(5):205-11 [17881903] Protein Expr Purif. 2000 Apr;18(3):293-302 [10733882] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/CVI.00081-08 ER - TY - JOUR T1 - Populations of p53 codon 270 CGT to TGT mutant cells in SKH-1 mouse skin tumors induced by simulated solar light. AN - 69740608; 18381587 AB - The p53 codon 270 CGT to TGT mutation was investigated as a biomarker of sunlight-induced mutagenesis and carcinogenesis. The relationship between tumor development and abundance of this hotspot mutation was analyzed in mouse skin tumors induced by chronic exposure to simulated solar light (SSL). The 24 tumors analyzed had similar growth kinetics, with an average doubling time of approximately 16.4 d. Levels of the p53 codon 270 mutation were quantified in the 24 mouse skin tumors using allele-specific competitive blocker-polymerase chain reaction (ACB-PCR). All tumors contained measurable amounts of the mutation. The p53 codon 270 CGT to TGT mutant fraction (MF) ranged from 2.29 x 10(-3) to 9.42 x 10(-2), with 3.26 x 10(-2) as the median. These p53 MF measurements are lower than expected for an initiating mutation involved in the development of tumors of monoclonal origin. There was no evidence of a correlation between p53 codon 270 MF and either tumor area or an estimate of tumor cell number. Thus, the data do not support the idea that p53 mutation accumulates linearly during tumor development. To investigate how p53 mutation was distributed within tumors, 19 needle biopsies from seven different tumors were analyzed by ACB-PCR. This analysis demonstrated that p53 codon 270 mutation is heterogeneously distributed within tumors. The long-term goal of this research is to combine morphological and p53 MF measurements from tissues corresponding to the various stages of tumor development, in order to derive mathematical models relating the p53 codon 270 mutation to the development of SSL-induced skin tumors. JF - Molecular carcinogenesis AU - Verkler, Tracie L AU - Delongchamp, Robert R AU - Couch, Letha H AU - Miller, Barbara J AU - Warbritton, Alan AU - Mellick, Paul W AU - Howard, Paul C AU - Parsons, Barbara L AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, USFDA, Jefferson, Arkansas 72079, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 822 EP - 834 VL - 47 IS - 11 KW - Codon KW - 0 KW - RNA, Messenger KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Animals KW - Base Sequence KW - Cell Transformation, Neoplastic -- radiation effects KW - Cell Transformation, Neoplastic -- metabolism KW - Sunlight KW - Mutation -- genetics KW - Mice KW - RNA, Messenger -- genetics KW - Cell Transformation, Neoplastic -- genetics KW - Skin Neoplasms -- genetics KW - Codon -- genetics KW - Neoplasms, Radiation-Induced -- pathology KW - Neoplasms, Radiation-Induced -- metabolism KW - Skin Neoplasms -- pathology KW - Neoplasms, Radiation-Induced -- genetics KW - Tumor Suppressor Protein p53 -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Skin Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69740608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Populations+of+p53+codon+270+CGT+to+TGT+mutant+cells+in+SKH-1+mouse+skin+tumors+induced+by+simulated+solar+light.&rft.au=Verkler%2C+Tracie+L%3BDelongchamp%2C+Robert+R%3BCouch%2C+Letha+H%3BMiller%2C+Barbara+J%3BWarbritton%2C+Alan%3BMellick%2C+Paul+W%3BHoward%2C+Paul+C%3BParsons%2C+Barbara+L&rft.aulast=Verkler&rft.aufirst=Tracie&rft.date=2008-11-01&rft.volume=47&rft.issue=11&rft.spage=822&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.20439 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20439 ER - TY - JOUR T1 - Estimation of required monitoring time for obtaining validation data in enclosed spaces. AN - 69733687; 18974904 AB - Methods for estimating airborne contaminant concentrations at specific locations within enclosed spaces, such as mathematical models and computational fluid dynamics (CFD), often are validated against directly measured concentrations. However, concentration variation with time introduces uncertainty into the measured concentration. Failure to determine monitoring time requirements can lead to errors in quantifying representative concentrations, which are likely to be attributed to errors in the method being validated. In the current study, to obtain the representative concentrations at multiple locations with a direct reading instrument, we used the standard deviation ratio (SDR) method to determine the required minimum monitoring time within a specified precision limit. To demonstrate the use of the SDR approach in constructing precision confidence intervals, tracer gas concentrations at nine sampling locations in an experimental room were measured to obtain population parameters. Three flow rates of 0.9, 3.3 and 5.5 m(3) min(-1) were employed and contaminant concentrations were measured using a photoionization analyser. Monitoring time requirements varied substantially with location within the room and were strongly dependent upon the flow rate of air through the room. The proposed method would be very useful for industrial hygienists and indoor air researchers who sometimes need to obtain several hundred measured concentrations for validation purposes or to perform tests under repeatable conditions in enclosed spaces. This study also showed that the proposed method can be used to devise efficient indoor monitoring strategies. JF - Journal of environmental monitoring : JEM AU - Lee, Eun Gyung AU - Feigley, Charles E AU - Hussey, James R AU - Slaven, James E AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. dtq5@cdc.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1350 EP - 1356 VL - 10 IS - 11 KW - Air Pollutants KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Spectrometry, Fluorescence KW - Reproducibility of Results KW - Spectrophotometry, Ultraviolet KW - Calorimetry KW - Air Pollutants -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69733687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Estimation+of+required+monitoring+time+for+obtaining+validation+data+in+enclosed+spaces.&rft.au=Lee%2C+Eun+Gyung%3BFeigley%2C+Charles+E%3BHussey%2C+James+R%3BSlaven%2C+James+E&rft.aulast=Lee&rft.aufirst=Eun&rft.date=2008-11-01&rft.volume=10&rft.issue=11&rft.spage=1350&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=1464-0333&rft_id=info:doi/10.1039%2Fb806421k LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/b806421k ER - TY - JOUR T1 - Routine diagnostic X-ray examinations and increased frequency of chromosome translocations among U.S. radiologic technologists. AN - 69732606; 18974125 AB - The U.S. population has nearly one radiographic examination per person per year, and concern about cancer risks associated with medical radiation has increased. Radiologic technologists were surveyed to determine whether their personal cumulative exposure to diagnostic X-rays was associated with increased frequencies of chromosome translocations, an established radiation biomarker and possible intermediary suggesting increased cancer risk. Within a large cohort of U.S. radiologic technologists, 150 provided a blood sample for whole chromosome painting and were interviewed about past X-ray examinations. The number and types of examinations reported were converted to a red bone marrow (RBM) dose score with units that approximated 1 mGy. The relationship between dose score and chromosome translocation frequency was assessed using Poisson regression. The estimated mean cumulative RBM radiation dose score was 49 (range, 0-303). After adjustment for age, translocation frequencies significantly increased with increasing RBM dose score with an estimate of 0.004 translocations per 100 cell equivalents per score unit (95% confidence interval, 0.002-0.007; P < 0.001). Removing extreme values or adjustment for gender, cigarette smoking, occupational radiation dose, allowing practice X-rays while training, work with radioisotopes, and radiotherapy for benign conditions did not affect the estimate. Cumulative radiation exposure from routine X-ray examinations was associated independently with increased chromosome damage, suggesting the possibility of elevated long-term health risks, including cancer. The slope estimate was consistent with expectation based on cytogenetic experience and atomic bomb survivor data. JF - Cancer research AU - Sigurdson, Alice J AU - Bhatti, Parveen AU - Preston, Dale L AU - Doody, Michele Morin AU - Kampa, Diane AU - Alexander, Bruce H AU - Petibone, Dayton AU - Yong, Lee C AU - Edwards, Alan A AU - Ron, Elaine AU - Tucker, James D AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. sigurdsa@mail.nih.gov Y1 - 2008/11/01/ PY - 2008 DA - 2008 Nov 01 SP - 8825 EP - 8831 VL - 68 IS - 21 KW - Index Medicus KW - United States KW - Aged, 80 and over KW - Humans KW - Cohort Studies KW - In Situ Hybridization, Fluorescence KW - Aged KW - Dose-Response Relationship, Radiation KW - Male KW - Female KW - Occupational Exposure KW - Technology, Radiologic -- manpower KW - Translocation, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69732606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Routine+diagnostic+X-ray+examinations+and+increased+frequency+of+chromosome+translocations+among+U.S.+radiologic+technologists.&rft.au=Sigurdson%2C+Alice+J%3BBhatti%2C+Parveen%3BPreston%2C+Dale+L%3BDoody%2C+Michele+Morin%3BKampa%2C+Diane%3BAlexander%2C+Bruce+H%3BPetibone%2C+Dayton%3BYong%2C+Lee+C%3BEdwards%2C+Alan+A%3BRon%2C+Elaine%3BTucker%2C+James+D&rft.aulast=Sigurdson&rft.aufirst=Alice&rft.date=2008-11-01&rft.volume=68&rft.issue=21&rft.spage=8825&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1691 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-08 N1 - Date created - 2008-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiat Res. 1998 Jun;149(6):602-13 [9611099] Radiat Res. 2008 Aug;170(2):149-55 [18666821] Radiat Res. 1999 Dec;152(6):655-64 [10581536] Radiat Res. 2001 Oct;156(4):337-46 [11554845] Int J Radiat Biol. 2001 Aug;77(8):901-8 [11571024] Radiat Prot Dosimetry. 2001;97(3):279-82; discussion 285 [11843345] Health Phys. 2002 Apr;82(4):455-66 [11906134] Health Phys. 2002 Dec;83(6):907-17 [12467299] Int J Cancer. 2003 Feb 10;103(4):556-62 [12478675] Health Phys. 2003 Feb;84(2):245-59 [12553655] Radiat Prot Dosimetry. 2003;103(1):35-40 [12596987] Am J Epidemiol. 2003 Apr 1;157(7):652-63 [12672685] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Health Phys. 2003 Jul;85(1):47-59 [12852471] Radiat Prot Dosimetry. 2003;106(2):131-5 [14653333] Lancet. 2004 Jan 31;363(9406):345-51 [15070562] Mutat Res. 1999 Jun 25;442(2):89-95 [10393277] Radiat Res. 2004 Sep;162(3):249-56 [15378837] Radiat Res. 2004 Oct;162(4):377-89 [15447045] Phys Med Biol. 1981 May;26(3):389-400 [7243876] Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7474-6 [1881886] Int J Radiat Biol. 1992 Jul;62(1):53-63 [1353776] Radiology. 1993 Nov;189(2):377-80 [8210363] Health Phys. 1995 Feb;68(2):266-9 [7814260] Cytogenet Cell Genet. 1995;68(3-4):211-21 [7842739] Mutat Res. 1995 Oct;338(1-6):95-106 [7565886] Mutagenesis. 1995 Nov;10(6):487-95 [8596467] Environ Health Perspect. 1996 May;104 Suppl 3:489-92 [8781370] Radiat Res. 1997 Sep;148(3):216-26 [9291352] Environ Mol Mutagen. 1997;30(3):264-72 [9366904] Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):229-48 [15657915] Radiat Prot Dosimetry. 2005;113(4):396-402 [15928034] Radiat Res. 2005 Nov;164(5):612-7 [16238438] Occup Environ Med. 2005 Dec;62(12):861-7 [16299095] Cancer. 2006 Jun 15;106(12):2707-15 [16639729] Radiat Res. 2006 Jul;166(1 Pt 2):174-92 [16808606] JAMA. 2006 Aug 9;296(6):638-40 [16896096] Mutat Res. 2006 Aug 30;600(1-2):37-45 [16814813] Radiat Res. 2007 Jun;167(6):727-34 [17523852] JAMA. 2007 Jul 18;298(3):317-23 [17635892] N Engl J Med. 2007 Nov 29;357(22):2277-84 [18046031] Mutat Res. 2008 Apr 30;652(2):112-21 [18337160] Radiology. 2008 Jul;248(1):254-63 [18566177] Int J Radiat Biol. 1998 Nov;74(5):565-71 [9848275] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1691 ER - TY - JOUR T1 - An evaluation of a data mining signal for amyotrophic lateral sclerosis and statins detected in FDA's spontaneous adverse event reporting system. AN - 69728074; 18821724 AB - We detected disproportionate reporting of amyotrophic lateral sclerosis (ALS) with HMG-CoA-reductase inhibitors (statins) in the Food and Drug Administration's (FDA) spontaneous adverse event (AE) reporting system (AERS). To describe the original ALS signal and to provide additional context for interpreting the signal by conducting retrospective analyses of data from long-term, placebo-controlled clinical trials of statins. The ALS signal was detected using the multi-item gamma Poisson shrinker (MGPS) algorithm. All AERS cases of ALS reported in association with use of a statin were individually reviewed by two FDA neurologists. Manufacturers of lovastatin, pravastatin, simvastatin, fluvastatin, atorvastatin, cerivastatin, and rosuvastatin were requested to provide the number of cases of ALS diagnosed during all of their placebo-controlled statin trials that were at least 6 months in duration. There were 91 US and foreign reports of ALS with statins in AERS. The data mining signal scores for ALS and statins ranged from 8.5 to 1.6. Data were obtained from 41 statin clinical trials ranging in duration from 6 months to 5 years and representing approximately 200,000 patient-years of exposure to statin and approximately 200,000 patient-years of exposure to placebo. Nine cases of ALS were reported in statin-treated patients and 10 cases in placebo-treated patients. Although we observed a data mining signal for ALS with statins in FDA's AERS, retrospective analyses of 41 statin clinical trials did not reveal an increased incidence of ALS in subjects treated with a statin compared with placebo. Copyright (c) 2008 John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and drug safety AU - Colman, Eric AU - Szarfman, Ana AU - Wyeth, Jo AU - Mosholder, Andrew AU - Jillapalli, Devanand AU - Levine, Jonathan AU - Avigan, Mark AD - Division of Metabolism and Endocrinology Products, United States Food and Drug Administration, Silver Spring, MD 20993, USA. eric.colman@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1068 EP - 1076 VL - 17 IS - 11 KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - 0 KW - Index Medicus KW - Controlled Clinical Trials as Topic KW - Aged, 80 and over KW - Humans KW - Adult KW - Retrospective Studies KW - Product Surveillance, Postmarketing KW - Algorithms KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - United States Food and Drug Administration -- statistics & numerical data KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Amyotrophic Lateral Sclerosis -- epidemiology KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Amyotrophic Lateral Sclerosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69728074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=An+evaluation+of+a+data+mining+signal+for+amyotrophic+lateral+sclerosis+and+statins+detected+in+FDA%27s+spontaneous+adverse+event+reporting+system.&rft.au=Colman%2C+Eric%3BSzarfman%2C+Ana%3BWyeth%2C+Jo%3BMosholder%2C+Andrew%3BJillapalli%2C+Devanand%3BLevine%2C+Jonathan%3BAvigan%2C+Mark&rft.aulast=Colman&rft.aufirst=Eric&rft.date=2008-11-01&rft.volume=17&rft.issue=11&rft.spage=1068&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=1099-1557&rft_id=info:doi/10.1002%2Fpds.1643 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-11 N1 - Date created - 2008-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pds.1643 ER - TY - JOUR T1 - Optical mapping and 454 sequencing of Escherichia coli O157 : H7 isolates linked to the US 2006 spinach-associated outbreak. AN - 69722725; 18957604 AB - Optical maps for five representative clinical, food-borne and bovine-derived isolates from the 2006 Escherichia coli O157 : H7 outbreak linked to fresh spinach in the United States showed a common set of 14 distinct chromosomal markers that define the outbreak strain. Partial 454 DNA sequencing was used to characterize the optically mapped chromosomal markers. The markers included insertions, deletions, substitutions and a simple single nucleotide polymorphism creating a BamHI site. The Shiga toxin gene profile of the spinach-associated outbreak isolates (stx1(-) stx2(+) stx2c(+)) correlated with prophage insertions different from those in the prototypical EDL933 and Sakai reference strains (stx1(+) stx2(+) stx2c(-)). The prophage occupying the yehV chromosomal position in the spinach-associated outbreak isolates was similar to the stx1(+) EDL933 cryptic prophage V, but it lacked the stx1 gene. In EDL933, the stx2 genes are within prophage BP933-W at the wrbA chromosomal locus; this locus was unoccupied in the spinach outbreak isolates. Instead, the stx2 genes were found within a chimeric BP933-W-like prophage with a different integrase, inserted at the argW locus in the outbreak isolates. An extra set of Shiga toxin genes, stx2c, was found in the outbreak isolates within a prophage integrated at the sbcB locus. The optical maps of two additional clinical isolates from the outbreak showed a single, different prophage variation in each, suggesting that changes occurred in the source strain during the course of this widespread, multi-state outbreak. JF - Microbiology (Reading, England) AU - Kotewicz, Michael L AU - Mammel, Mark K AU - LeClerc, J Eugene AU - Cebula, Thomas A AD - Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 3518 EP - 3528 VL - 154 SN - 1350-0872, 1350-0872 KW - Shiga Toxins KW - 0 KW - Index Medicus KW - Animals KW - Prophages -- genetics KW - Food Microbiology KW - Cattle -- microbiology KW - Polymorphism, Genetic KW - Humans KW - Shiga Toxins -- genetics KW - Food Contamination -- analysis KW - Chromosomes, Bacterial -- genetics KW - United States -- epidemiology KW - Escherichia coli Infections -- microbiology KW - Escherichia coli Infections -- epidemiology KW - Escherichia coli O157 -- isolation & purification KW - Restriction Mapping KW - Spinacia oleracea -- microbiology KW - Escherichia coli O157 -- virology KW - Disease Outbreaks KW - Escherichia coli O157 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69722725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+%28Reading%2C+England%29&rft.atitle=Optical+mapping+and+454+sequencing+of+Escherichia+coli+O157+%3A+H7+isolates+linked+to+the+US+2006+spinach-associated+outbreak.&rft.au=Kotewicz%2C+Michael+L%3BMammel%2C+Mark+K%3BLeClerc%2C+J+Eugene%3BCebula%2C+Thomas+A&rft.aulast=Kotewicz&rft.aufirst=Michael&rft.date=2008-11-01&rft.volume=154&rft.issue=&rft.spage=3518&rft.isbn=&rft.btitle=&rft.title=Microbiology+%28Reading%2C+England%29&rft.issn=13500872&rft_id=info:doi/10.1099%2Fmic.0.2008%2F019026-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-22 N1 - Date created - 2008-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1099/mic.0.2008/019026-0 ER - TY - JOUR T1 - Amoxicillin for postexposure inhalational anthrax in pediatrics: rationale for dosing recommendations. AN - 69719402; 18833025 AB - We reviewed information about the safety and plasma pharmacokinetic data for amoxicillin, specifically related to its potential use for postexposure inhalational anthrax. Amoxicillin (45 mg/kg/d) given orally in 3 divided doses to pediatric patients <40 kg should yield an adequate time above the MIC for susceptible Bacillus anthracis (< or =0.5 microg/mL) over most of the dosing interval (75-100%). Doses <45 mg/kg/d and dosing intervals longer than 8 hours should not be used for postexposure inhalational anthrax. JF - The Pediatric infectious disease journal AU - Alexander, John J AU - Colangelo, Philip M AU - Cooper, Charles K AU - Roberts, Rosemary AU - Rodriguez, William J AU - Murphy, Mary D AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 955 EP - 957 VL - 27 IS - 11 SN - 0891-3668, 0891-3668 KW - Amoxicillin KW - 804826J2HU KW - Index Medicus KW - Infant KW - Humans KW - Infant, Newborn KW - Child KW - Microbial Sensitivity Tests KW - Child, Preschool KW - Bacillus anthracis -- drug effects KW - Amoxicillin -- therapeutic use KW - Amoxicillin -- administration & dosage KW - Inhalation Exposure KW - Amoxicillin -- pharmacokinetics KW - Amoxicillin -- adverse effects KW - Anthrax -- prevention & control KW - Anthrax -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69719402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Pediatric+infectious+disease+journal&rft.atitle=Amoxicillin+for+postexposure+inhalational+anthrax+in+pediatrics%3A+rationale+for+dosing+recommendations.&rft.au=Alexander%2C+John+J%3BColangelo%2C+Philip+M%3BCooper%2C+Charles+K%3BRoberts%2C+Rosemary%3BRodriguez%2C+William+J%3BMurphy%2C+Mary+D&rft.aulast=Alexander&rft.aufirst=John&rft.date=2008-11-01&rft.volume=27&rft.issue=11&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=The+Pediatric+infectious+disease+journal&rft.issn=08913668&rft_id=info:doi/10.1097%2FINF.0b013e31817bf9a9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-01 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/INF.0b013e31817bf9a9 ER - TY - JOUR T1 - Antimicrobial resistance in Salmonella enterica serovar Heidelberg isolates from retail meats, including poultry, from 2002 to 2006. AN - 69714800; 18757574 AB - Salmonella enterica serovar Heidelberg frequently causes food-borne illness in humans. There are few data on the prevalence, antimicrobial susceptibility, and genetic diversity of Salmonella serovar Heidelberg isolates in retail meats. We compared the prevalences of Salmonella serovar Heidelberg in a sampling of 20,295 meats, including chicken breast (n = 5,075), ground turkey (n = 5,044), ground beef (n = 5,100), and pork chops (n = 5,076), collected during 2002 to 2006. Isolates were analyzed for antimicrobial susceptibility and compared genetically using pulsed-field gel electrophoresis (PFGE) and PCR for the bla(CMY) gene. A total of 298 Salmonella serovar Heidelberg isolates were recovered, representing 21.6% of all Salmonella serovars from retail meats. One hundred seventy-eight (59.7%) were from ground turkey, 110 (36.9%) were from chicken breast, and 10 (3.4%) were from pork chops; none was found in ground beef. One hundred ninety-eight isolates (66.4%) were resistant to at least one compound, and 49 (16.4%) were resistant to at least five compounds. Six isolates (2.0%), all from ground turkey, were resistant to at least nine antimicrobials. The highest resistance in poultry isolates was to tetracycline (39.9%), followed by streptomycin (37.8%), sulfamethoxazole (27.7%), gentamicin (25.7%), kanamycin (21.5%), ampicillin (19.8%), amoxicillin-clavulanic acid (10.4%), and ceftiofur (9.0%). All isolates were susceptible to ceftriaxone and ciprofloxacin. All ceftiofur-resistant strains carried bla(CMY). PFGE using XbaI and BlnI showed that certain clones were widely dispersed in different types of meats and meat brands from different store chains in all five sampling years. These data indicate that Salmonella serovar Heidelberg is a common serovar in retail poultry meats and includes widespread clones of multidrug-resistant strains. JF - Applied and environmental microbiology AU - Zhao, S AU - White, D G AU - Friedman, S L AU - Glenn, A AU - Blickenstaff, K AU - Ayers, S L AU - Abbott, J W AU - Hall-Robinson, E AU - McDermott, P F AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, US Food and Drug Administration, Laurel, MD 20708, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 6656 EP - 6662 VL - 74 IS - 21 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Swine KW - Animals KW - Turkeys KW - DNA Fingerprinting KW - Drug Resistance, Multiple, Bacterial KW - beta-Lactamases -- genetics KW - Polymerase Chain Reaction KW - Cattle KW - Chickens KW - Meat Products -- microbiology KW - DNA, Bacterial -- genetics KW - Electrophoresis, Gel, Pulsed-Field KW - Microbial Sensitivity Tests KW - Prevalence KW - Salmonella enterica -- isolation & purification KW - Drug Resistance, Bacterial KW - Salmonella enterica -- genetics KW - Food Contamination KW - Anti-Bacterial Agents -- pharmacology KW - Meat -- microbiology KW - Salmonella enterica -- classification KW - Salmonella enterica -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69714800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Antimicrobial+resistance+in+Salmonella+enterica+serovar+Heidelberg+isolates+from+retail+meats%2C+including+poultry%2C+from+2002+to+2006.&rft.au=Zhao%2C+S%3BWhite%2C+D+G%3BFriedman%2C+S+L%3BGlenn%2C+A%3BBlickenstaff%2C+K%3BAyers%2C+S+L%3BAbbott%2C+J+W%3BHall-Robinson%2C+E%3BMcDermott%2C+P+F&rft.aulast=Zhao&rft.aufirst=S&rft.date=2008-11-01&rft.volume=74&rft.issue=21&rft.spage=6656&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.01249-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 2001 Dec;45(12):3647-50 [11709361] Foodborne Pathog Dis. 2008 Apr;5(2):115-26 [18361686] Ann Saudi Med. 2004 Jul-Aug;24(4):270-2 [15387492] JAMA. 1980 Feb 8;243(6):546-7 [7351786] MMWR Morb Mortal Wkly Rep. 1986 Feb 14;35(6):91 [3080662] Epidemiol Infect. 1989 Oct;103(2):227-34 [2806415] J Am Geriatr Soc. 1990 May;38(5):531-4 [2332575] J Emerg Med. 1990 May-Jun;8(3):295-7 [2373838] Clin Infect Dis. 1995 Oct;21(4):1065 [8645823] Infect Control Hosp Epidemiol. 1997 Feb;18(2):115-21 [9120239] World Health Stat Q. 1997;50(1-2):81-9 [9282390] Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25 [10511517] Epidemiol Infect. 2005 Oct;133(5):809-16 [16181499] Foodborne Pathog Dis. 2006 Spring;3(1):59-67 [16602980] Foodborne Pathog Dis. 2006 Spring;3(1):106-17 [16602986] J Food Prot. 2006 May;69(5):1150-3 [16715818] PLoS One. 2007;2(3):e309 [17375195] J Food Prot. 2007 Jun;70(6):1328-33 [17612059] J Antimicrob Chemother. 2007 Aug;60(2):398-401 [17526503] Antimicrob Agents Chemother. 2004 Aug;48(8):2845-52 [15273090] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.01249-08 ER - TY - JOUR T1 - Method for estimating ultraviolet germicidal fluence rates in a hospital room. AN - 69704664; 18844468 AB - Upper-room air UV germicidal irradiation (UVGI) is an effective environmental control measure for mitigating the transmission of airborne infections. Many factors influence the efficacy of an upper-room air UVGI system, including the levels and distribution of radiation. The radiation levels experienced by airborne microorganisms can be estimated by measuring the fluence rate, which is the irradiance from all angles that is incident on a small region of space. The fluence rate can be estimated by use of a radiometer coupled to a planar detector. Measurements in 4 directions at a single point are taken and summed to estimate the fluence rate at that point. This measurement process is repeated at different sites in the room at a single height. In the upper air of a test room, the UV fluence rate varied at least 3-fold, with the maximum rate occurring in the immediate vicinity of the fixtures containing lamps emitting UV radiation. In the area that would be occupied by the patient and/or healthcare personnel, no significant variation occurred in the UV fluence rate for a designated height. There was no significant statistical difference between measurements obtained by different individuals, by using a different alignment, or during 5 observation periods. Lamp failures were detected on multiple occasions. This method is simple, requires no specialized training, and permits regular monitoring of the necessary UV fluence rates needed to sustain the targeted airborne microorganisms' inactivation level. Additionally, this method allowed for the detection of changes in UV fluence rates in the upper air of the simulated hospital room. JF - Infection control and hospital epidemiology AU - Schafer, Millie P AU - Kujundzic, Elmira AU - Moss, Clyde E AU - Miller, Shelly L AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1099, USA. mps3@cdc.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1042 EP - 1047 VL - 29 IS - 11 KW - Index Medicus KW - Nursing KW - Radiometry KW - Patients' Rooms KW - Air Pollution, Indoor -- prevention & control KW - Ultraviolet Rays KW - Infection Control -- standards KW - Infection Control -- methods KW - Infection Control -- instrumentation KW - Air Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69704664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+control+and+hospital+epidemiology&rft.atitle=Method+for+estimating+ultraviolet+germicidal+fluence+rates+in+a+hospital+room.&rft.au=Schafer%2C+Millie+P%3BKujundzic%2C+Elmira%3BMoss%2C+Clyde+E%3BMiller%2C+Shelly+L&rft.aulast=Schafer&rft.aufirst=Millie&rft.date=2008-11-01&rft.volume=29&rft.issue=11&rft.spage=1042&rft.isbn=&rft.btitle=&rft.title=Infection+control+and+hospital+epidemiology&rft.issn=1559-6834&rft_id=info:doi/10.1086%2F591856 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/591856 ER - TY - JOUR T1 - Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. AN - 69693934; 18725543 AB - Emerging evidence suggests that the rewarding, abuse-related effects of nicotine are modulated by the endocannabinoid system of the brain. For example, pharmacological blockade or genetic deletion of cannabinoid CB(1) receptors can reduce or eliminate many abuse-related behavioral and neurochemical effects of nicotine. Furthermore, doses of Delta(9)-tetrahydrocannabinol and nicotine that are ineffective when given alone can induce conditioned place preference when given together. These previous studies have used systemically administered CB(1) receptor agonists and antagonists and gene deletion techniques, which affect cannabinoid CB(1) receptors throughout the brain. A more functionally selective way to alter endocannabinoid activity is to inhibit fatty acid amide hydrolase (FAAH), thereby magnifying and prolonging the effects of the endocannabinoid anandamide only when and where it is synthesized and released on demand. Here, we combined behavioral and neurochemical approaches to evaluate whether the FAAH inhibitor URB597 (cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester) could alter the abuse-related effects of nicotine in rats. We found that URB597, at a dose (0.3 mg/kg) that had no behavioral effects by itself, prevented development of nicotine-induced conditioned place preference (CPP) and acquisition of nicotine self-administration. URB597 also reduced nicotine-induced reinstatement in both CPP and self-administration models of relapse. Furthermore, in vivo microdialysis showed that URB597 reduced nicotine-induced dopamine elevations in the nucleus accumbens shell, the terminal area of the brain's mesolimbic reward system. These findings suggest that FAAH inhibition can counteract the addictive properties of nicotine and that FAAH may serve as a new target for development of medications for treatment of tobacco dependence. JF - The Journal of pharmacology and experimental therapeutics AU - Scherma, Maria AU - Panlilio, Leigh V AU - Fadda, Paola AU - Fattore, Liana AU - Gamaleddin, Islam AU - Le Foll, Bernard AU - Justinová, Zuzana AU - Mikics, Eva AU - Haller, Jozsef AU - Medalie, Julie AU - Stroik, Jessica AU - Barnes, Chanel AU - Yasar, Sevil AU - Tanda, Gianluigi AU - Piomelli, Daniele AU - Fratta, Walter AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 482 EP - 490 VL - 327 IS - 2 KW - Arachidonic Acids KW - 0 KW - Benzamides KW - Carbamates KW - Endocannabinoids KW - Polyunsaturated Alkamides KW - cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester KW - Nicotine KW - 6M3C89ZY6R KW - Amidohydrolases KW - EC 3.5.- KW - fatty-acid amide hydrolase KW - EC 3.5.1.- KW - anandamide KW - UR5G69TJKH KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Self Administration KW - Rats, Long-Evans KW - Reward KW - Motor Activity -- drug effects KW - Hydrolysis KW - Male KW - Carbamates -- pharmacology KW - Nucleus Accumbens -- chemistry KW - Nucleus Accumbens -- drug effects KW - Arachidonic Acids -- metabolism KW - Polyunsaturated Alkamides -- metabolism KW - Conditioning (Psychology) -- drug effects KW - Benzamides -- pharmacology KW - Tobacco Use Disorder -- drug therapy KW - Amidohydrolases -- physiology KW - Nicotine -- pharmacology KW - Dopamine -- analysis KW - Amidohydrolases -- antagonists & inhibitors KW - Tobacco Use Disorder -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69693934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Inhibition+of+anandamide+hydrolysis+by+cyclohexyl+carbamic+acid+3%27-carbamoyl-3-yl+ester+%28URB597%29+reverses+abuse-related+behavioral+and+neurochemical+effects+of+nicotine+in+rats.&rft.au=Scherma%2C+Maria%3BPanlilio%2C+Leigh+V%3BFadda%2C+Paola%3BFattore%2C+Liana%3BGamaleddin%2C+Islam%3BLe+Foll%2C+Bernard%3BJustinov%C3%A1%2C+Zuzana%3BMikics%2C+Eva%3BHaller%2C+Jozsef%3BMedalie%2C+Julie%3BStroik%2C+Jessica%3BBarnes%2C+Chanel%3BYasar%2C+Sevil%3BTanda%2C+Gianluigi%3BPiomelli%2C+Daniele%3BFratta%2C+Walter%3BGoldberg%2C+Steven+R&rft.aulast=Scherma&rft.aufirst=Maria&rft.date=2008-11-01&rft.volume=327&rft.issue=2&rft.spage=482&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.142224 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nicotine Tob Res. 1999;1 Suppl 2:S121-5; discussion S139-40 [11768168] Br J Pharmacol. 2002 Jan;135(2):564-78 [11815392] Neuropharmacology. 2002 Oct;43(5):857-67 [12384171] Behav Pharmacol. 2002 Sep;13(5-6):451-63 [12394421] Brain Res. 2002 Nov 1;954(1):73-81 [12393235] J Neurobiol. 2002 Dec;53(4):606-17 [12436424] Nat Med. 2003 Jan;9(1):76-81 [12461523] Eur J Neurosci. 2003 Apr;17(8):1723-6 [12752390] Synapse. 2003 Oct;50(1):1-6 [12872287] J Biol Chem. 2003 Aug 15;278(33):30429-34 [12761211] Science. 2003 Oct 3;302(5642):84-8 [14526074] Curr Drug Targets CNS Neurol Disord. 2003 Dec;2(6):389-402 [14683467] J Neurosci. 2004 Jan 7;24(1):53-62 [14715937] J Med Chem. 2004 Oct 7;47(21):4998-5008 [15456244] Neuroreport. 2004 Sep 15;15(13):2139-43 [15486497] Eur J Pharmacol. 1987 Sep 23;141(3):395-9 [3666033] Psychopharmacology (Berl). 1989;99(4):473-8 [2594913] Brain Res. 1994 Aug 8;653(1-2):278-84 [7982062] Nature. 1994 Dec 15;372(6507):686-91 [7990962] Nature. 1996 Jul 18;382(6588):255-7 [8717040] Psychopharmacology (Berl). 1997 Jan;129(1):35-43 [9122361] Psychopharmacology (Berl). 1997 Apr;130(4):396-403 [9160857] Nature. 1998 Jan 8;391(6663):173-7 [9428762] Behav Pharmacol. 1997 Dec;8(8):707-12 [9832956] Psychopharmacology (Berl). 2005 Apr;178(4):481-92 [15765262] J Pharmacol Exp Ther. 2005 Apr;313(1):352-8 [15579492] Pharmacol Biochem Behav. 2005 Jun;81(2):381-6 [15925402] Nature. 2005 Jul 7;436(7047):103-7 [16001069] Psychopharmacology (Berl). 2005 Oct;181(4):722-34 [15986197] AAPS J. 2005;7(3):E625-54 [16353941] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18620-5 [16352709] Psychopharmacology (Berl). 2006 Mar;184(3-4):367-81 [16205918] Psychopharmacology (Berl). 2006 Mar;184(3-4):339-44 [16416156] CNS Drug Rev. 2006 Spring;12(1):21-38 [16834756] J Pharmacol Exp Ther. 2006 Aug;318(2):563-70 [16702440] Curr Opin Lipidol. 2007 Apr;18(2):129-40 [17353660] Mol Pharmacol. 2007 Oct;72(4):1024-32 [17628012] Br J Pharmacol. 2007 Nov;152(5):734-43 [17906680] Biol Psychiatry. 2007 Nov 15;62(10):1103-10 [17511970] Neuropharmacology. 2008 Jan;54(1):129-40 [17904589] Neuropharmacology. 2008 Feb;54(2):438-44 [18054052] J Neurochem. 2008 May;105(4):1235-43 [18194436] J Pharmacol Exp Ther. 2008 Aug;326(2):483-92 [18451315] Biol Psychiatry. 2008 Dec 1;64(11):930-7 [18814866] Erratum In: J Pharmacol Exp Ther. 2011 Jun;337(3):887 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.142224 ER - TY - JOUR T1 - Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabant. AN - 69671876; 18305459 AB - Accumulating evidence suggests the endocannabinoid system modulates environmental cues' ability to induce seeking of drugs, including nicotine and alcohol. However, little attention has been directed toward extending these advances to the growing problem of cannabis use disorders. Therefore, we studied intravenous self-administration of Delta(9)-tetrahydrocannabinol (THC), the main psychoactive constituent of marijuana, using a second-order schedule of drug seeking. Squirrel monkeys' lever responses produced only a brief cue light until the end of the session, when the final response delivered THC along with the cue. When a reinstatement procedure was used to model relapse following a period of abstinence, THC-seeking behavior was robustly reinstated by the cue or by pre-session administration of THC, other cannabinoid agonists, or morphine, but not cocaine. The cannabinoid antagonist rimonabant blocked cue-induced drug seeking, THC-induced drug seeking, and the direct reinforcing effects of THC. Thus, rimonabant and related medications might be effective as treatments for cannabinoid dependence. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Justinova, Zuzana AU - Munzar, Patrik AU - Panlilio, Leigh V AU - Yasar, Sevil AU - Redhi, Godfrey H AU - Tanda, Gianluigi AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Department of Health and Human Services, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 2870 EP - 2877 VL - 33 IS - 12 KW - Analgesics, Opioid KW - 0 KW - Cannabinoid Receptor Modulators KW - Piperidines KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - Morphine KW - 76I7G6D29C KW - Dronabinol KW - 7J8897W37S KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Reinforcement (Psychology) KW - Disease Models, Animal KW - Cannabinoid Receptor Modulators -- antagonists & inhibitors KW - Morphine -- pharmacology KW - Saimiri KW - Cannabinoid Receptor Modulators -- agonists KW - Self Administration KW - Cannabinoid Receptor Modulators -- metabolism KW - Analgesics, Opioid -- pharmacology KW - Cues KW - Secondary Prevention KW - Male KW - Piperidines -- pharmacology KW - Brain -- physiopathology KW - Pyrazoles -- pharmacology KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Marijuana Abuse -- metabolism KW - Brain Chemistry -- drug effects KW - Brain -- drug effects KW - Marijuana Abuse -- drug therapy KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Brain -- metabolism KW - Marijuana Abuse -- physiopathology KW - Dronabinol -- antagonists & inhibitors KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69671876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Blockade+of+THC-seeking+behavior+and+relapse+in+monkeys+by+the+cannabinoid+CB%281%29-receptor+antagonist+rimonabant.&rft.au=Justinova%2C+Zuzana%3BMunzar%2C+Patrik%3BPanlilio%2C+Leigh+V%3BYasar%2C+Sevil%3BRedhi%2C+Godfrey+H%3BTanda%2C+Gianluigi%3BGoldberg%2C+Steven+R&rft.aulast=Justinova&rft.aufirst=Zuzana&rft.date=2008-11-01&rft.volume=33&rft.issue=12&rft.spage=2870&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.21 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2006 Aug 16;26(33):8531-6 [16914679] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Brain Res Rev. 2007 Jan;53(1):1-16 [16839608] Behav Pharmacol. 2007 Feb;18(1):61-9 [17218798] Eur J Neurosci. 2007 Apr;25(7):2191-200 [17419755] Psychopharmacology (Berl). 2005 May;179(2):452-60 [15821957] J Neurosci. 2005 Jun 8;25(23):5645-50 [15944392] Pharmacol Biochem Behav. 2005 Jun;81(2):285-99 [15932767] Pharmacol Biochem Behav. 2005 Jun;81(2):387-95 [15935455] Trends Pharmacol Sci. 2005 Aug;26(8):420-6 [15992935] Psychopharmacology (Berl). 2006 Jan;183(4):394-403 [16261315] Trends Neurosci. 2006 Apr;29(4):225-32 [16483675] Addiction. 2007 Dec;102(12):1863-70 [18031422] Nat Neurosci. 2000 Nov;3(11):1073-4 [11036260] Behav Pharmacol. 2000 Aug;11(5):377-86 [11103889] Psychopharmacology (Berl). 2000 Dec;153(1):17-30 [11255926] J Neurosci. 2001 Jul 15;21(14):5344-50 [11438610] Nat Med. 2001 Oct;7(10):1151-4 [11590440] Psychopharmacology (Berl). 2002 Oct;163(3-4):327-44 [12373434] Behav Pharmacol. 2002 Sep;13(5-6):451-63 [12394421] J Pharmacol Exp Ther. 2003 Jul;306(1):93-102 [12660305] Psychopharmacology (Berl). 2003 Jul;168(1-2):164-9 [12669182] Psychopharmacology (Berl). 2003 Sep;169(2):135-40 [12827345] Psychopharmacology (Berl). 2004 Apr;173(1-2):186-94 [14668977] JAMA. 2004 May 5;291(17):2114-21 [15126440] Br J Pharmacol. 2004 Oct;143(3):343-50 [15339858] J Pharmacol Exp Ther. 1973 Jul;186(1):18-30 [4198773] Fed Proc. 1975 Aug;34(9):1771-6 [1149889] Psychopharmacology (Berl). 1977 Mar 16;51(3):235-42 [403538] Psychopharmacology (Berl). 1998 Dec;140(3):331-44 [9877013] Pharmacol Biochem Behav. 1999 Oct;64(2):327-36 [10515309] Neuropsychopharmacology. 2006 Dec;31(12):2652-9 [16541083] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.21 ER - TY - JOUR T1 - Characteristics of grandmothers who have grandchildren with fetal alcohol syndrome or incomplete fetal alcohol syndrome. AN - 69634019; 18196450 AB - Characteristics of Northern Plains American Indian maternal grandmothers who had grandchildren with fetal alcohol syndrome (FAS) or incomplete FAS are described to more effectively prevent fetal FAS and alcohol use during pregnancy. Study 1 had 27 maternal grandmothers who had grandchildren with FAS and Study 2 had 18 grandmothers with grandchildren who had incomplete FAS (cases) which were compared with 119 maternal grandmothers who had grandchildren without FAS (controls). The grandchildren were born between 1981 and 1993 on the Northern Plains. Medical records were manually reviewed for each case and control grandmother. Data were analyzed using Mantel-Haenszel chi square. Study 1 case grandmothers were more likely to experience medical problems (70.4%) including trauma (48.1%) and injuries (51.9%) than the controls. Most of the Study 1 and 2 case grandmothers (92.6% and 77.8%, respectively) had alcohol use documented in their medical records compared to less than half of the control grandmothers. Seven (15.6%) of the case grandmothers had more than one grandchild in either Study 1 or Study 2. Maternal grandmothers who had grandchildren with FAS had significantly higher rates of alcohol use and alcohol-related medical problems than control grandmothers. Antenatal care providers should screen pregnant women for alcohol use at their first visit. The provider needs to ask the women who are using alcohol about their mothers' use of alcohol to provide appropriate care and counseling for the women and prevent FAS. JF - Maternal and child health journal AU - Kvigne, Valborg L AU - Leonardson, Gary R AU - Borzelleca, Joseph AU - Welty, Thomas K AD - Aberdeen Area Indian Health Service, Aberdeen, SD, USA. kvig6@aol.com Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 760 EP - 765 VL - 12 IS - 6 SN - 1092-7875, 1092-7875 KW - Index Medicus KW - Odds Ratio KW - Humans KW - Midwestern United States -- epidemiology KW - Child, Preschool KW - Pregnancy KW - Indians, North American KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Female KW - Male KW - Prevalence KW - Family Relations KW - Alcoholism -- epidemiology KW - Intergenerational Relations KW - Fetal Alcohol Spectrum Disorders -- epidemiology KW - Alcoholism -- complications KW - Fetal Alcohol Spectrum Disorders -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69634019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maternal+and+child+health+journal&rft.atitle=Characteristics+of+grandmothers+who+have+grandchildren+with+fetal+alcohol+syndrome+or+incomplete+fetal+alcohol+syndrome.&rft.au=Kvigne%2C+Valborg+L%3BLeonardson%2C+Gary+R%3BBorzelleca%2C+Joseph%3BWelty%2C+Thomas+K&rft.aulast=Kvigne&rft.aufirst=Valborg&rft.date=2008-11-01&rft.volume=12&rft.issue=6&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=Maternal+and+child+health+journal&rft.issn=10927875&rft_id=info:doi/10.1007%2Fs10995-007-0308-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10995-007-0308-y ER - TY - JOUR T1 - Genomic analysis of polycyclic aromatic hydrocarbon degradation in Mycobacterium vanbaalenii PYR-1. AN - 69588576; 18421421 AB - Mycobacterium vanbaalenii PYR-1 is well known for its ability to degrade a wide range of high-molecular-weight (HMW) polycyclic aromatic hydrocarbons (PAHs). The genome of this bacterium has recently been sequenced, allowing us to gain insights into the molecular basis for the degradation of PAHs. The 6.5 Mb genome of PYR-1 contains 194 chromosomally encoded genes likely associated with degradation of aromatic compounds. The most distinctive feature of the genome is the presence of a 150 kb major catabolic region at positions 494 approximately 643 kb (region A), with an additional 31 kb region at positions 4,711 approximately 4,741 kb (region B), which is predicted to encode most enzymes for the degradation of PAHs. Region A has an atypical mosaic structure made of several gene clusters in which the genes for PAH degradation are complexly arranged and scattered around the clusters. Significant differences in the gene structure and organization as compared to other well-known aromatic hydrocarbon degraders including Pseudomonas and Burkholderia were revealed. Many identified genes were enriched with multiple paralogs showing a remarkable range of diversity, which could contribute to the wide variety of PAHs degraded by M. vanbaalenii PYR-1. The PYR-1 genome also revealed the presence of 28 genes involved in the TCA cycle. Based on the results, we proposed a pathway in which HMW PAHs are degraded into the beta-ketoadipate pathway through protocatechuate and then mineralized to CO2 via TCA cycle. We also identified 67 and 23 genes involved in PAH degradation and TCA cycle pathways, respectively, to be expressed as proteins. JF - Biodegradation AU - Kim, Seong-Jae AU - Kweon, Ohgew AU - Jones, Richard C AU - Edmondson, Ricky D AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 859 EP - 881 VL - 19 IS - 6 KW - Adipates KW - 0 KW - DNA Transposable Elements KW - Environmental Pollutants KW - Polycyclic Aromatic Hydrocarbons KW - 3-oxoadipic acid KW - 1379JRA56F KW - Index Medicus KW - Phylogeny KW - Genome, Bacterial KW - Adipates -- metabolism KW - Citric Acid Cycle -- genetics KW - Biodegradation, Environmental KW - Inactivation, Metabolic -- genetics KW - DNA Transposable Elements -- genetics KW - Models, Biological KW - Mycobacterium -- genetics KW - Environmental Pollutants -- metabolism KW - Mycobacterium -- metabolism KW - Polycyclic Aromatic Hydrocarbons -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69588576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biodegradation&rft.atitle=Genomic+analysis+of+polycyclic+aromatic+hydrocarbon+degradation+in+Mycobacterium+vanbaalenii+PYR-1.&rft.au=Kim%2C+Seong-Jae%3BKweon%2C+Ohgew%3BJones%2C+Richard+C%3BEdmondson%2C+Ricky+D%3BCerniglia%2C+Carl+E&rft.aulast=Kim&rft.aufirst=Seong-Jae&rft.date=2008-11-01&rft.volume=19&rft.issue=6&rft.spage=859&rft.isbn=&rft.btitle=&rft.title=Biodegradation&rft.issn=1572-9729&rft_id=info:doi/10.1007%2Fs10532-008-9189-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-14 N1 - Date created - 2008-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10532-008-9189-z ER - TY - JOUR T1 - Engineering case reports: evaluation of a local exhaust ventilation system for controlling exposures during liquid flavoring production. AN - 69513213; 18770075 JF - Journal of occupational and environmental hygiene AU - Old, Leo AU - Dunn, Kevin H AU - Garcia, Alberto AU - Echt, Alan AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - D103 EP - D110 VL - 5 IS - 11 KW - Flavoring Agents KW - 0 KW - Index Medicus KW - Occupational Exposure -- prevention & control KW - Flavoring Agents -- chemical synthesis KW - Food-Processing Industry KW - Ventilation -- instrumentation KW - Ventilation -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69513213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Engineering+case+reports%3A+evaluation+of+a+local+exhaust+ventilation+system+for+controlling+exposures+during+liquid+flavoring+production.&rft.au=Old%2C+Leo%3BDunn%2C+Kevin+H%3BGarcia%2C+Alberto%3BEcht%2C+Alan&rft.aulast=Old&rft.aufirst=Leo&rft.date=2008-11-01&rft.volume=102&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Basic+%26+clinical+pharmacology+%26+toxicology&rft.issn=1742-7843&rft_id=info:doi/10.1111%2Fj.1742-7843.2007.00184.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620802363274 ER - TY - JOUR T1 - Analytical performance criteria. Field evaluation of diacetyl sampling and analytical methods. AN - 69467589; 18726763 JF - Journal of occupational and environmental hygiene AU - Ashley, Kevin AU - McKernan, Lauralynn Taylor AU - Burroughs, Edward AU - Deddens, James AU - Pendergrass, Stephanie AU - Streicher, Robert P AD - National Institute for Occupational Safety and Health, Cincinnati,Ohio, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - D111 EP - D116 VL - 5 IS - 11 KW - Air Pollutants, Occupational KW - 0 KW - Acetoin KW - BG4D34CO2H KW - Diacetyl KW - K324J5K4HM KW - Index Medicus KW - United States KW - Humans KW - Humidity KW - National Institute for Occupational Safety and Health (U.S.) KW - Diacetyl -- analysis KW - Air Pollutants, Occupational -- analysis KW - Acetoin -- analysis KW - Environmental Monitoring -- standards KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69467589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Analytical+performance+criteria.+Field+evaluation+of+diacetyl+sampling+and+analytical+methods.&rft.au=Ashley%2C+Kevin%3BMcKernan%2C+Lauralynn+Taylor%3BBurroughs%2C+Edward%3BDeddens%2C+James%3BPendergrass%2C+Stephanie%3BStreicher%2C+Robert+P&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2008-11-01&rft.volume=5&rft.issue=3&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620802363282 ER - TY - JOUR T1 - Integration of viral hepatitis services into opioid treatment programs. AN - 66675932; 19192765 AB - Opioid treatment programs (OTPs) dispense methadone and buprenorphine under specific federal regulations to individuals diagnosed with opioid dependence. OTPs can provide a comprehensive therapeutic milieu, often including primary medical care, psychosocial counseling, vocational rehabilitation, ongoing performance monitoring, and other vital services. Because of the high prevalence of infectious diseases, particularly hepatitis C virus infection, model OTPs are developing comprehensive care and treatment programs that integrate general medical and infectious disease-related medical care with substance abuse and mental health services. Integrating hepatitis care services in the substance abuse treatment settings fosters access to care for patients with multiple comorbidities, many who otherwise would not receive needed care. Improving health related outcomes for this patient population with complex medical problems requires an advanced integrated model of care for OTPs that can be exemplified through establishing resources needed to prevent hepatitis infection as standard of care. Outcomes management becomes possible through enhancing current capability of existing dispensing programs. This may serve as a national model for highly cost-efficient healthcare that has a measurable outcome of improved health. JF - Journal of opioid management AU - Kresina, Thomas F AU - Bruce, R Douglas AU - Lubran, Robert AU - Clark, H Westley AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA. PY - 2008 SP - 369 EP - 381 VL - 4 IS - 6 SN - 1551-7489, 1551-7489 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - United States KW - Young Adult KW - Patient Education as Topic KW - Humans KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Methadone -- therapeutic use KW - Hepatitis, Viral, Human -- drug therapy KW - Substance Abuse Treatment Centers -- organization & administration KW - Opioid-Related Disorders -- complications KW - Hepatitis, Viral, Human -- complications KW - Narcotics -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Mental Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66675932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+opioid+management&rft.atitle=Integration+of+viral+hepatitis+services+into+opioid+treatment+programs.&rft.au=Kresina%2C+Thomas+F%3BBruce%2C+R+Douglas%3BLubran%2C+Robert%3BClark%2C+H+Westley&rft.aulast=Kresina&rft.aufirst=Thomas&rft.date=2008-11-01&rft.volume=4&rft.issue=6&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Journal+of+opioid+management&rft.issn=15517489&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-26 N1 - Date created - 2009-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational Racial Composition and Nonfatal Work Injuries AN - 59855779; 200906921 AB - Is there an association between occupational racial composition and nonfatal workplace injuries? Guided by several labor market theories (queuing, social closure, devaluation, poor market position, and human capital), we use occupational data from the U.S. Census and Dictionary of Occupational Titles combined with individual data from the National Longitudinal Survey of Youth to answer this question. Hierarchical generalized linear models of individuals within occupations show that there is an association between occupational racial composition and workplace injuries, but this association is only statistically significant for white men in the model controlling for relevant occupational and individual level characteristics. A 10 percent increase in the occupation percent black is associated with a 28 percent increase in injury risk. Contrary to expectations, white men have the highest adjusted odds of injury; white women and black men have significantly lower odds of injury than white men. Additionally, occupation-level environmental hazards and individual-level education, hours worked per week, jobs with insurance benefits, working in the South, and specific industries are associated with differential injury risk. These findings are consistent with labor market theories that suggest social closure, market position, and individual skills contribute to differential labor market outcomes. We demonstrate that sociological theories of labor market inequality are useful for understanding workplace injury risk, and that workplace injuries should be studied as an outcome of social inequality. Adapted from the source document. JF - Social Problems AU - Berdahl, Terceira A AU - McQuillan, Julia AD - Center for Financing, Access, and Cost Trends, Agency for Health Care Research and Quality, 540 Gaither Road, Suite 5000, Rockville, MD 20850 terceira.berdahl@ahrq.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 549 EP - 572 PB - The University of California Press, Berkeley CA VL - 55 IS - 4 SN - 0037-7791, 0037-7791 KW - occupational racial composition, work injury, health, labor markets, and social inequality KW - Injuries KW - Occupational Safety and Health KW - Social Inequality KW - Labor Market Segmentation KW - United States of America KW - Racial Differences KW - article KW - 9221: politics and society; politics and society UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59855779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Problems&rft.atitle=Occupational+Racial+Composition+and+Nonfatal+Work+Injuries&rft.au=Berdahl%2C+Terceira+A%3BMcQuillan%2C+Julia&rft.aulast=Berdahl&rft.aufirst=Terceira&rft.date=2008-11-01&rft.volume=55&rft.issue=4&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=Social+Problems&rft.issn=00377791&rft_id=info:doi/10.1525%2Fsp.2008.55.4.549 LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2009-03-03 N1 - Number of references - 51 N1 - Last updated - 2016-09-28 N1 - CODEN - SOPRAG N1 - SubjectsTermNotLitGenreText - Occupational Safety and Health; Racial Differences; Injuries; Labor Market Segmentation; Social Inequality; United States of America DO - http://dx.doi.org/10.1525/sp.2008.55.4.549 ER - TY - JOUR T1 - Quality Assurance and Improvement Practice in Mental Health Agencies: Roles, Activities, Targets and Contributions AN - 57282865; 200904353 AB - Accompanying the rise in the number of mental health agency personnel tasked with quality assurance and improvement (QA/I) responsibilities is an increased need to understand the nature of the work these professionals undertake. Four aspects of the work of quality assurance and improvement (QA/I) professionals in mental health were explored in this qualitative study: their perceived roles, their major activities, their QA/I targets, and their contributions. In-person interviews were conducted with QA/I professionals at 16 mental health agencies. Respondents perceived their roles at varying levels of complexity, focused on different targets, and used different methods to conduct their work. Few targets of QA/I work served as indicators of high quality care. Most QA/I professionals provided concrete descriptions of how they had improved agency services, while others could describe none. Accreditation framed much of agency QA/I work, perhaps to its detriment. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - McMillen, Curtis AU - Zayas, Luis E AU - Books, Samantha AU - Lee, Madeline AD - Center for Mental Health Services Research George Warren Brown School of Social Work, Washington University in St. Louis, Washington University Campus Box 1196, One Brookings Drive, St. Louis, MO 63130, USA Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 458 EP - 467 PB - Springer, Dordrecht The Netherlands VL - 35 IS - 6 SN - 0894-587X, 0894-587X KW - Quality of care KW - Quality assurance KW - Mental health professionals KW - Mental health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57282865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Quality+Assurance+and+Improvement+Practice+in+Mental+Health+Agencies%3A+Roles%2C+Activities%2C+Targets+and+Contributions&rft.au=McMillen%2C+Curtis%3BZayas%2C+Luis+E%3BBooks%2C+Samantha%3BLee%2C+Madeline&rft.aulast=McMillen&rft.aufirst=Curtis&rft.date=2008-11-01&rft.volume=35&rft.issue=6&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-008-0189-4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Mental health; Quality assurance; Quality of care; Mental health professionals DO - http://dx.doi.org/10.1007/s10488-008-0189-4 ER - TY - JOUR T1 - Signal-Averaged Electrocardiogram in Physically Healthy, Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Users AN - 57277808; 200903991 AB - Objectives: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) use has been associated with cardiac arrhythmias. Markers of ventricular late potentials (VLP), which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG), but not by standard ECG. Methods: We evaluated SA-ECG parameters in 21 physically healthy, recently abstinent MDMA users who also used cannabis (11 males, mean [SD] age 23.3 [4.6] years, 2.8 [2.0] years of use), 18 physically healthy cannabis users (8 males, mean [SD] age 26.6 [7.1] years, 11.2 [5.4] years of use) and 54 non-drug-using controls (21 males, mean [SD] age 28.4 [7.8] years). We analyzed three SA-ECG parameters considered markers of VLPs: duration of filtered QRS complex (fQRS), duration of low amplitude potentials during terminal 40 ms of QRS complex (LAS40), and root mean square voltage during terminal 40 ms of QRS complex (RMS40). Results: MDMA users, cannabis users, and non-drug-using controls did not differ significantly from each other in fQRS, LAS40, or RMS40 values or in the proportion of subjects with abnormal SA-ECG parameters. There were significant gender differences among controls, but not among MDMA users. Conclusion: These findings suggest that chronic MDMA use is neither quantitatively nor qualitatively associated with a high prevalence of abnormal SA-ECG parameters indicative of VLP markers. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Kanneganti, Praveen AU - Huestis, Marilyn A AU - Kolbrich, Erin A AU - Goodwin, Robert AU - Ziegelstein, Roy C AU - Gorelick, David A AD - Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 712 EP - 720 PB - Taylor & Francis Inc., Philadelphia, PA VL - 34 IS - 6 SN - 0095-2990, 0095-2990 KW - Heart arrhythmia KW - Ecstasy drug KW - Echocardiography KW - Cannabis KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57277808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Signal-Averaged+Electrocardiogram+in+Physically+Healthy%2C+Chronic+3%2C4-Methylenedioxymethamphetamine+%28MDMA%29+Users&rft.au=Kanneganti%2C+Praveen%3BHuestis%2C+Marilyn+A%3BKolbrich%2C+Erin+A%3BGoodwin%2C+Robert%3BZiegelstein%2C+Roy+C%3BGorelick%2C+David+A&rft.aulast=Kanneganti&rft.aufirst=Praveen&rft.date=2008-11-01&rft.volume=34&rft.issue=6&rft.spage=712&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.1080%2F00952990802308254 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Ecstasy drug; Cannabis; Echocardiography; Heart arrhythmia DO - http://dx.doi.org/10.1080/00952990802308254 ER - TY - JOUR T1 - Go out or stay in? The effects of zero tolerance laws on alcohol use and drinking and driving patterns among college students AN - 57273080; 200902002 AB - Zero tolerance laws make it illegal per se for anyone under age 21 to drive with any measurable amount of blood alcohol. Although a link has been established between zero tolerance laws and lower motor vehicle fatalities, research has not produced strong evidence on how zero tolerance laws influence individual alcohol use and drinking and driving behaviors. Using a unique data set and a difference-in-difference-in-difference-type research design, we are able to analyze a number of pathways through which zero tolerance laws can work among an important underage population, college students. We find that zero tolerance laws reduce drinking and driving among college students. Further analysis of our detailed alcohol use measures suggests that zero tolerance laws are particularly effective at reducing the probability of driving after drinking for those who reported drinking away from home. [Copyright 2008 John Wiley and Sons, Ltd.] JF - Health Economics AU - Liang, Lan AU - Huang, Jidong AD - Agency for Healthcare Research and Quality, USA lliang@ahrq.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1261 EP - 1275 PB - John Wiley, Chichester UK VL - 17 IS - 11 SN - 1057-9230, 1057-9230 KW - Alcohol consumption KW - Underage KW - Driving KW - Zero tolerance KW - Legislation KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57273080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Go+out+or+stay+in%3F+The+effects+of+zero+tolerance+laws+on+alcohol+use+and+drinking+and+driving+patterns+among+college+students&rft.au=Liang%2C+Lan%3BHuang%2C+Jidong&rft.aulast=Liang&rft.aufirst=Lan&rft.date=2008-11-01&rft.volume=17&rft.issue=11&rft.spage=1261&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1321 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Zero tolerance; Driving; Undergraduate students; Alcohol consumption; Legislation; Underage DO - http://dx.doi.org/10.1002/hec.1321 ER - TY - JOUR T1 - Healthy Start: Lessons Learned on Interconception Care AN - 57250304; 200905455 AB - The Federal Healthy Start program was started in 1991 to address the factors that contribute to the Nation's high infant mortality rate, particularly among populations with disproportionately high rates of adverse perinatal health outcomes. The goals of Healthy Start are to reduce disparities in access to and utilization of health services by using a lifespan approach, improving the local health care system, and increasing consumer and community input into health care decisions. In 2007, Healthy Start served 99 communities in 38 states, the District of Columbia, and Puerto Rico. Most Healthy Start grantees are nonprofit organizations. Since 2005, all 97 Healthy Start grantees (and the 2 additional grantees funded in 2007) have been required to include an interconception care component. Three quarters of grantees enrolled the majority of their interconception clients during the prenatal period. Most grantees used care coordination and case management as the primary approach to improving interconception health care. In 2007, 93 interconception projects reported that 9 out of 10 women had an ongoing source of primary care. Grantees screened to detect health conditions and risks, as well as provided an opportunity to provide vital information to women about their risks for chronic conditions such as obesity, hypertension, and diabetes. The Healthy Start interconception components demonstrate a critical need for and the potential impact of a strong interconception care program for high-risk populations such as women living in poverty, in medically underserved communities, and without health coverage. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Badura, Maribeth AU - Johnson, Kay AU - Hench, Karen AU - Reyes, Madelyn AD - U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, Division of Healthy Start and Perinatal Services, Rockville, Maryland mbadura@hrsa.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - S61 EP - S66 PB - Elsevier Science, New York NY VL - 18 IS - 6S1 SN - 1049-3867, 1049-3867 KW - Case management KW - Coverage KW - Health care KW - Life span KW - Perinatal KW - Women KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Healthy+Start%3A+Lessons+Learned+on+Interconception+Care&rft.au=Badura%2C+Maribeth%3BJohnson%2C+Kay%3BHench%2C+Karen%3BReyes%2C+Madelyn&rft.aulast=Badura&rft.aufirst=Maribeth&rft.date=2008-11-01&rft.volume=18&rft.issue=6S1&rft.spage=S61&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2008.07.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Women; Health care; Perinatal; Case management; Coverage; Life span DO - http://dx.doi.org/10.1016/j.whi.2008.07.010 ER - TY - JOUR T1 - Mycobacterium bovis BCG Immunization Induces Protective Immunity against Nine Different Mycobacterium tuberculosis Strains in Mice , AN - 21498808; 12495231 AB - Recent preclinical and epidemiologic studies have suggested that certain Mycobacterium tuberculosis genotypes (in particular, Beijing lineage strains) may be resistant to Mycobacterium bovis BCG vaccine-induced antituberculosis protective immunity. To investigate the strain specificity of BCG-induced protective responses in a murine model of pulmonary tuberculosis, C57BL/6 mice were vaccinated with BCG vaccine and then challenged 2 months later with one of nine M. tuberculosis isolates. Four of these strains were from the W-Beijing lineage (HN878, N4, NHN5, and ChS) while four were non-Beijing-type isolates (C913, CDC1551, NY669, and NY920). As a control, the WHO standard M. tuberculosis Erdman strain was evaluated in these vaccination/challenge experiments. To assess the protective responses evoked by BCG immunization, organ bacterial burdens and lung pathology were assessed in vaccinated and naive mice at 4, 12, and 20 weeks postchallenge as well as during the day of infection. At 4 weeks after the aerosol challenge with each of these strains, significantly reduced bacterial growth in the lungs and spleens and significantly improved lung pathology were seen in all vaccinated animals compared to naive controls. After 12 weeks, reduced organ bacterial burdens were detected in vaccinated animals infected with six of nine challenge strains. Although lung CFU values were lower in vaccinated mice for only three of nine groups at 20 weeks postchallenge, significantly decreased lung inflammation was seen in all immunized animals relative to controls at 20 weeks postchallenge. Taken together, these data demonstrate that BCG vaccination protects against infection with diverse M. tuberculosis strains in the mouse model of pulmonary tuberculosis and suggest that strain-specific resistance to BCG-induced protective immunity may be uncommon. JF - Infection and Immunity AU - Jeon, Bo Young AU - Derrick, Steven C AU - Lim, JaeHyun AU - Kolibab, Kristopher AU - Dheenadhayalan, Veerabadran AU - Yang, Amy Li AU - Kreiswirth, Barry AU - Morris, Sheldon L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland, sheldon.morris@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 5173 EP - 5180 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 11 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Aerosols KW - Data processing KW - Animal models KW - Spleen KW - Mycobacterium bovis KW - Immunity KW - Genotypes KW - Infection KW - Vaccination KW - Inflammation KW - BCG KW - Lung KW - Colony-forming cells KW - Tuberculosis KW - Vaccines KW - Mycobacterium tuberculosis KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21498808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Mycobacterium+bovis+BCG+Immunization+Induces+Protective+Immunity+against+Nine+Different+Mycobacterium+tuberculosis+Strains+in+Mice+%2C&rft.au=Jeon%2C+Bo+Young%3BDerrick%2C+Steven+C%3BLim%2C+JaeHyun%3BKolibab%2C+Kristopher%3BDheenadhayalan%2C+Veerabadran%3BYang%2C+Amy+Li%3BKreiswirth%2C+Barry%3BMorris%2C+Sheldon+L&rft.aulast=Jeon&rft.aufirst=Bo&rft.date=2008-11-01&rft.volume=76&rft.issue=11&rft.spage=5173&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00019-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Aerosols; Data processing; Animal models; Spleen; Genotypes; Immunity; Infection; Vaccination; Inflammation; Lung; BCG; Colony-forming cells; Tuberculosis; Vaccines; Mycobacterium bovis; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/IAI.00019-08 ER - TY - JOUR T1 - Effects of Thrombosed Vena Cava Filters on Blood Flow: Flow Visualization and Numerical Modeling AN - 21296463; 11901420 AB - Inferior vena cava (IVC) filters are used to prevent pulmonary embolism (PE) in patients with deep vein thrombosis for whom anticoagulation is contraindicated. IVC filters have been shown to be effective in trapping embolized clots and preventing PE; however, among the commercially available designs, the optimal balance of clot capture efficiency, clot dissolution, and prevention of to vena cava occlusion is unknown. Clot capture efficiency has been quantified in numerous invitro studies, in which model clots are released into a mock circulation system, with the relative capture efficiency of various IVC filters analyzed statistically. In general, two-stage filters have been found to be more efficient than one-stage filters. However, other factors may play a role in the ultimate dissolution of clots and in the overall effect of the resulting blood flow on caval vasculature. Clot dissolution has been shown to increase with increasing wall shear stress, while low and oscillating wall shear stresses are known to have a deleterious effect on vessel walls, causing intimal hyperplasia. This paper describes the effect of IVC filters on blood flow, velocity patterns, and wall shear stress by flow visualization and computational fluid dynamics. JF - Annals of Biomedical Engineering AU - Stewart, Sandy FC AU - Robinson, Ronald A AU - Nelson, Robert A AU - Malinauskas, Richard A AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, White Oak Bldg 62, Rm 2210, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA, sandy.stewart@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1764 EP - 1781 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 36 IS - 11 SN - 0090-6964, 0090-6964 KW - Biotechnology and Bioengineering Abstracts KW - Statistical analysis KW - Computer applications KW - Trapping KW - Thrombosis KW - Mechanical stimuli KW - Filters KW - Hyperplasia KW - Veins KW - Lung KW - Embolism KW - Occlusion KW - Dissolution KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21296463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=Effects+of+Thrombosed+Vena+Cava+Filters+on+Blood+Flow%3A+Flow+Visualization+and+Numerical+Modeling&rft.au=Stewart%2C+Sandy+FC%3BRobinson%2C+Ronald+A%3BNelson%2C+Robert+A%3BMalinauskas%2C+Richard+A&rft.aulast=Stewart&rft.aufirst=Sandy&rft.date=2008-11-01&rft.volume=36&rft.issue=11&rft.spage=1764&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1007%2Fs10439-008-9560-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Filters; Mechanical stimuli; Dissolution; Hyperplasia; Embolism; Occlusion; Statistical analysis; Trapping; Thrombosis; Veins; Computer applications; Lung DO - http://dx.doi.org/10.1007/s10439-008-9560-6 ER - TY - RPRT T1 - Key Design Factors of Enclosed Cab Dust Filtration Systems AN - 20773942; 10308235 AB - Enclosed cabs are a primary means of reducing the silica dust exposure of equipment operators at surface mines. The National Institute for Occupational Safety and Health experimentally investigated various factor effects on cab air filtration system performance. The factors investigated were intake filter efficiency, intake air leakage, intake filter loading (filter flow resistance), recirculation filter use, and wind effects on cab particulate penetration. Adding an intake pressurizer fan to the filtration system was also investigated. Results indicate that intake filter efficiency and recirculation filter use were the two most influential factors on cab penetration performance. Use of the recirculation filter reduced cab penetration by usually an order of magnitude over the intake air filter alone because of the multiplicative filtration of the cab interior air. Intake air leakage and filter loading affected the cab penetration to a lesser extent, while wind had the least impact on cab penetration between the calm and 10-mph wind velocities tested. Adding an intake pressurizer fan notably increased intake airflow and cab pressure with only minor changes to cab penetration. A mathematical model was developed that describes cab penetration in terms of intake filter efficiency, intake air quantity, intake air leakage, recirculation filter efficiency, recirculation filter quantity, and wind penetration. JF - Key Design Factors of Enclosed Cab Dust Filtration Systems. 51 pp. Nov 2008. AU - Organiscak, JA AU - Cecala, AB Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 51 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Occupational safety KW - Particulates KW - Dust KW - air flow KW - silica KW - Air flow KW - Pollutant removal KW - Mathematical models KW - Leakage KW - Velocity KW - Mines KW - Design KW - Filtration KW - Air purification KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20773942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Organiscak%2C+JA%3BCecala%2C+AB&rft.aulast=Organiscak&rft.aufirst=JA&rft.date=2008-11-01&rft.volume=&rft.issue=&rft.spage=51&rft.isbn=&rft.btitle=Key+Design+Factors+of+Enclosed+Cab+Dust+Filtration+Systems&rft.title=Key+Design+Factors+of+Enclosed+Cab+Dust+Filtration+Systems&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Lactobacillus-mediated inhibition of clinical toxic shock syndrome Staphylococcus aureus strains and its relation to acid and peroxide production AN - 20532896; 9213695 AB - The inhibitory activities of 39 strains representing 20 different species of Lactobacillus toward a menstrual toxic shock syndrome (TSS) Staphylococcus aureus archetype strain MN8 were investigated. Nearly every strain (38 of 39) produced an inhibitory effect under both aerobic and anaerobic conditions when assayed on agar medium. In addition, the MN8 inhibition was conserved against at least 10 other clinical TSS S. aureus isolates and, interestingly, required actively growing cultures of Lactobacillus (verified with a two-well co-culture system in broth medium). This general uniform inhibition could be ameliorated by organic buffer (PIPES) supplied in the growth medium and, with only one exception, MRS medium adjusted with non-organic acid (HCl) failed to support growth of TSS strains at or below pH 5.5. By comparison, the vast majority of lactobacilli in this study decreased culture pH to a range of 4-5. Hydrogen peroxide production by the lactobacilli was also assessed and verified by two different methodologies revealing a broad spectrum of phenotypes that, contrary to reports touting its effectiveness, did not seem to correspond with our inhibition studies. Furthermore, resistances to peroxide by MN8, other TSS strains, and a subset of lactobacilli used in this study were nearly identical whereas the S. aureus collection was slightly more sensitive to racemic lactic acid than the lactobacilli. Collectively, these data suggest that the underlying inhibition toward Staphylococcus is generally conserved in Lactobacillus sp. and is related to a common factor in this genus involving promotion of acidic conditions. JF - Anaerobe AU - Elklns, CA AU - Munoz, ME AU - Mullis, L B AU - Stingley, R L AU - Hart, ME AD - Division of Microbiology, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Drive, Jefferson, AR 72079-9502, USA Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 261 EP - 267 VL - 14 IS - 5 SN - 1075-9964, 1075-9964 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Agar KW - Lactobacillus KW - Data processing KW - Hydrogen peroxide KW - Lactic acid KW - Menstruation KW - Staphylococcus aureus KW - Anaerobic conditions KW - pH effects KW - Toxic shock syndrome KW - J 02320:Cell Biology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20532896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Lactobacillus-mediated+inhibition+of+clinical+toxic+shock+syndrome+Staphylococcus+aureus+strains+and+its+relation+to+acid+and+peroxide+production&rft.au=Elklns%2C+CA%3BMunoz%2C+ME%3BMullis%2C+L+B%3BStingley%2C+R+L%3BHart%2C+ME&rft.aulast=Elklns&rft.aufirst=CA&rft.date=2008-11-01&rft.volume=14&rft.issue=5&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2008.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Agar; Data processing; Hydrogen peroxide; Lactic acid; Menstruation; Anaerobic conditions; pH effects; Toxic shock syndrome; Lactobacillus; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.anaerobe.2008.08.003 ER - TY - JOUR T1 - A Review of Work Schedule Issues and Musculoskeletal Disorders with an Emphasis on the Healthcare Sector AN - 20350399; 9024605 AB - Musculoskeletal disorders (MSDs) are a significant cause of morbidity in healthcare workers. The influence of shift work and long work hours on risk for MSDs is an area that needs further exploration. The purpose of this report is to assess research progress and gaps across studies that examined the relationship between demanding work schedules and MSD outcomes. A literature search identified 23 peer-reviewed publications in the English language that examined MSDs and long work hours, shift work, extended work shifts, mandatory overtime, or weekend work. Eight studies that examined long work hours and had some controls for physical job demands reported a significant increase in one or more measures of MSDs. Fourteen studies examining shift work had incomparable methods and types of shift work, and therefore, no clear trends in findings were identified. A small number of studies examined mandatory overtime, work on weekends and days off, and less than 10 h off between shifts. Given the complexity of the work schedule research topic, relatively few studies have adequately examined the relationship of work schedules and musculoskeletal outcomes. The review discusses research gaps including methodological issues and suggests research priorities. JF - Industrial Health AU - Caruso, C C AU - Waters, T R AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), Division of Applied Research and Technology, 4676 Columbia Parkway MS C-24, Cincinnati, OH 45226-1998, USA Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 523 EP - 534 VL - 46 IS - 6 SN - 0019-8366, 0019-8366 KW - Risk Abstracts; Health & Safety Science Abstracts KW - shift work KW - Health care KW - Reviews KW - working conditions KW - musculoskeletal system KW - Medical personnel KW - Morbidity KW - Occupational health KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20350399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=A+Review+of+Work+Schedule+Issues+and+Musculoskeletal+Disorders+with+an+Emphasis+on+the+Healthcare+Sector&rft.au=Caruso%2C+C+C%3BWaters%2C+T+R&rft.aulast=Caruso&rft.aufirst=C&rft.date=2008-11-01&rft.volume=46&rft.issue=6&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - shift work; Health care; Reviews; Morbidity; Medical personnel; musculoskeletal system; working conditions; Occupational health ER - TY - JOUR T1 - Deaths Due to Bloodborne Infections and Their Sequelae Among Health-Care Workers AN - 20251934; 8891720 AB - Background The odds of dying from bloodborne infections among health-care workers has not been well studied. Methods Using data from the National Occupational Mortality Surveillance (NOMS) system, a matched case-control design was employed to examine the relationship between health-care employment and death from HIV, hepatitis B (HBV), hepatitis C (HCV; non-A/non-B viral hepatitis), liver cancer, and cirrhosis from 1984 to 2004. We examined the whole health-care industry and specific health-care occupations. Results From 1984 to 2004, NOMS captured 248,550 deaths from bloodborne pathogens and their sequelae. Employment in the health-care industry was associated with increased risk of death from HIV (MOR=2.27; 95% confidence interval [CI]=2.11-2.44), HBV (MOR=1.98; CI=1.58-2.48), and cirrhosis (MOR=1.09; CI=1.04-1.15) among males, and death from HCV among both males (MOR=1.46; CI=1.22-1.75) and females (MOR=1.22; CI=1.05-1.40). Nursing was the occupation with the highest MORs among males for HIV and HBV, but female nurses were at decreased risk of dying from HIV (MOR=0.69; CI=0.57-0.83). Conclusions Employment in the health-care industry was found to be associated with deaths from several bloodborne pathogens and their sequelae among males, but only with HCV among females from 1984 to 2004 in this exploratory study. Am. J. Ind. Med. 51:812-824, 2008. Published 2008 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Luckhaupt, Sara E AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, sluckhaupt@cdc.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 812 EP - 824 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 51 IS - 11 SN - 0271-3586, 0271-3586 KW - Virology & AIDS Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - employment KW - Liver cancer KW - hepatitis B KW - Infection KW - Medical personnel KW - Workers KW - Nursing KW - infection KW - Hepatitis B KW - Hepatitis C KW - Mortality KW - Cirrhosis KW - Data processing KW - Hepatitis B virus KW - Complications KW - Pathogens KW - Cancer KW - Hepatitis KW - Hepatitis C virus KW - Human immunodeficiency virus KW - Liver KW - nursing KW - R2 23080:Industrial and labor KW - V 22360:AIDS and HIV KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20251934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Deaths+Due+to+Bloodborne+Infections+and+Their+Sequelae+Among+Health-Care+Workers&rft.au=Luckhaupt%2C+Sara+E%3BCalvert%2C+Geoffrey+M&rft.aulast=Luckhaupt&rft.aufirst=Sara&rft.date=2008-11-01&rft.volume=51&rft.issue=11&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20610 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Workers; Data processing; Cirrhosis; Complications; Liver cancer; Nursing; Hepatitis B; Hepatitis C; Pathogens; Infection; Hepatitis; employment; Human immunodeficiency virus; Liver; infection; hepatitis B; nursing; Medical personnel; Cancer; Hepatitis C virus; Hepatitis B virus DO - http://dx.doi.org/10.1002/ajim.20610 ER - TY - JOUR T1 - Determination of orhto-phthalaldehyde in air and on surfaces AN - 20239029; 8852894 AB - Three sampling and analytical methods have been developed and evaluated for ortho-phthalaldehyde (OPA): (1) an HPLC-UV method for OPA in air, (2) a fluorimetric method for OPA on surfaces, and (3) a colorimetric method for OPA on surfaces. (1) The air sampler contains 350 mg of silica gel coated with 1 mg of acidified 2,4-dinitrophenylhydrazine (DNPH). Air sampling may be conducted at 0.03 to 1.0 L min super(-1) for periods up to 8 h. Samples were eluted with ethyl acetate, and the eluents were allowed to stand for 72 h. Analysis was by high performance liquid chromatography (HPLC) with a UV detector set at 369 nm. An unusual phenomenon was the observation that the stability of the sample on a sampler at 3 degree C tends to decrease as the total quantity of OPA collected on the sampler decreases. Elution of the samples within 24 h of air sampling is required. The detection limit (LOD) is approximately 0.02 mu g of OPA per sample. OPA on surfaces may be collected with strips cut from a sheet of polyvinyl alcohol (PVA wipe). (2) In the surface wipe method with analysis by fluorescence measurement, the strips of PVA wipe were placed into dimethyl sulfoxide. An aliquot was treated with aqueous N-acetyl-L-cysteine and ethylenediamine. Analysis was performed with a portable fluorometer (excitation and emission wavelengths = 365 nm and 438 nm, respectively). The LOD is 0.2 mu g per sample. (3) In the surface wipe method with visual colorimetric detection, the strips of PVA wipe were placed into 30: 70 acetonitrile: water. An aliquot was treated with N-(1-naphthyl)ethylenediamine in 0.1 m sulfuric acid. After color development, the LOD is approximately 48 mu g per sample. These methods have been field tested in a hospital. JF - Journal of Environmental Monitoring AU - Tucker, S P AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA, sptl@cdc.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1337 EP - 1349 VL - 10 IS - 11 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Environment Abstracts KW - Alcohol KW - Fluorescence KW - Liquid chromatography KW - Air sampling KW - Sulfuric acid KW - Emissions KW - Acidification KW - checked KW - Hospitals KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20239029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Determination+of+orhto-phthalaldehyde+in+air+and+on+surfaces&rft.au=Tucker%2C+S+P&rft.aulast=Tucker&rft.aufirst=S&rft.date=2008-11-01&rft.volume=10&rft.issue=11&rft.spage=1337&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb809790a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Alcohol; Fluorescence; Liquid chromatography; Emissions; Sulfuric acid; Air sampling; Acidification; checked; Hospitals DO - http://dx.doi.org/10.1039/b809790a ER - TY - RPRT T1 - Explosion Effects on Mine Ventilation Stoppings AN - 20153640; 10308234 AB - The National Institute for Occupational Safety and Health (NIOSH) and the Mine Safety and Health Administration (MSHA) conducted joint research to evaluate explosion blast effects on typical U.S. mine ventilation stoppings in the Pittsburgh Research Laboratory (PRL) Lake Lynn Experimental Mine (LLEM). An innovative Australian-designed brattice stopping was also evaluated. After mine explosion accidents, MSHA conducts investigations to determine the cause(s) as a means to prevent future occurrences. As part of these postexplosion investigations, the condition of underground stoppings, including the debris from damaged stoppings, is documented as evidence of the approximate strength and the direction of the explosion forces. The LLEM data showed that a typical dry-stacked and coated solid-concrete-block stopping survived a total explosion pressure of similar to 6.7 psi ( similar to 46 kPa) and was destroyed at a total explosion pressure of similar to 7.6 psi ( similar to 52 kPa). In comparison, a typical dry-stacked and coated hollow-core concrete block stopping survived a total explosion pressure of similar to 3.4-4.3 psi ( similar to 23-30 kPa) and was destroyed at a total explosion pressure of similar to 3.6-5.2 psi ( similar to 25-36 kPa), depending on the length of the pressure pulse and the value of the pressure-time integral. A typical steel panel stopping design survived a total explosion pressure of 0.8 psi (5.5 kPa) and failed at a total explosion pressure of 1.3 psi (9 kPa). The LLEM data also showed that an obstacle blocking the path of a pressure wave resulted in a higher reflected pressure at the obstacle. An 8-in (20-cm) thick wet-laid solid concrete-block stopping coated on one side survived a total explosion pressure of similar to 26 psi ( similar to 180 kPa); this stopping was not tested to failure. A 6-in (15-cm) thick wet-laid solid-concrete block stopping coated on one side survived a total explosion pressure of similar to 14 psi ( similar to 97 kPa) and was destroyed at a total explosion pressure of similar to 25 psi ( similar to 172 kPa). An innovative Australian woven cloth stopping survived an explosion pressure of 4.0 psi (27 kPa) and was destroyed at an explosion pressure of similar to 6.1 psi ( similar to 42 kPa). These results will help investigators determine the approximate explosion forces that destroy or damage stoppings during actual coal mine explosions. JF - Explosion Effects on Mine Ventilation Stoppings. [np]. Nov 2008. AU - Weiss, E S AU - Cashdollar, K L AU - Harteis, S P AU - Shemon, G J AU - Beiter, DA AU - Urosek, JE Y1 - 2008/11// PY - 2008 DA - Nov 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Safety regulations KW - Ventilation KW - Occupational safety KW - Coal KW - Concrete KW - Accidents KW - Lakes KW - Australia KW - Steel KW - Laboratory testing KW - Mines KW - Explosions KW - USA KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20153640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Weiss%2C+E+S%3BCashdollar%2C+K+L%3BHarteis%2C+S+P%3BShemon%2C+G+J%3BBeiter%2C+DA%3BUrosek%2C+JE&rft.aulast=Weiss&rft.aufirst=E&rft.date=2008-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Explosion+Effects+on+Mine+Ventilation+Stoppings&rft.title=Explosion+Effects+on+Mine+Ventilation+Stoppings&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Fire Fighter Fatality Investigation and Prevention Program: Leading Recommendations for Preventing Fire Fighter Fatalities, 1998-2005 AN - 20144915; 10308233 AB - This document is a synthesis of the 1,286 individual recommendations from the 335 FFFIPP investigations conducted from 1998 to 2005. We hope that the fire service will use this document as a resource and catalyst for developing, updating, and implementing effective policies, programs, and training to prevent fatalities among fire fighters. JF - Fire Fighter Fatality Investigation and Prevention Program: Leading Recommendations for Preventing Fire Fighter Fatalities, 1998-2005. [np]. Nov 2008. AU - Anonymous Y1 - 2008/11// PY - 2008 DA - Nov 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - Fires KW - Training KW - prevention KW - Catalysts KW - H 7000:Fire Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20144915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Fire+Fighter+Fatality+Investigation+and+Prevention+Program%3A+Leading+Recommendations+for+Preventing+Fire+Fighter+Fatalities%2C+1998-2005&rft.title=Fire+Fighter+Fatality+Investigation+and+Prevention+Program%3A+Leading+Recommendations+for+Preventing+Fire+Fighter+Fatalities%2C+1998-2005&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - A Performance Evaluation of Two Overhead Power Line Proximity Warning Devices AN - 20144337; 10308236 AB - Accidental contact of overhead electrical power lines by mobile equipment is a leading cause of occupational fatalities in the United States, accounting for 20% of on-the-job electrocutions. Overhead electrical power line proximity warning devices (PWDs) are intended to warn personnel if mobile equipment moves within some preselected minimum distance of an energized overhead electrical power line. Two commercially available PWDs were tested at the National Institute for Occupational Safety and Healths (NIOSH) Pittsburgh Research Laboratory (PRL). The objective of the tests was to document performance capabilities and limitations for these PWDs by identifying factors that can influence their operation. The two PWDs evaluated in this research are the SIGALARM Model 210 marketed by Allied Safety Systems, LLC, and the ASE Model 2100 from Allied Safety Engineering. Both of these devices operate by measuring the electric field present around energized power lines. The PWDs were installed on a government-owned 22-st (20-mt) rough terrain crane. A purpose-built test site used for this research at PRL allowed operation of the crane near a variety of power line configurations operating at up to 25 kV. Test results show that several factors can adversely affect PWD performance. PWD alarm accuracy generally deteriorated when operating with a boom position significantly different than that used for the last sensitivity adjustment of the device. Another factor that can affect PWD performance is configuration of the overhead power line(s) involved. Accuracy of alarm activation distances was best for simple single-circuit installations, but degraded for multiple circuits on the same poles. This degradation was slightly greater for installations with different voltage levels and/or a combination of vertical and horizontal conductor arrangements. Performance also degraded for crane operation between two intersecting power line installations, especially for intersecting lines at different voltages. An additional aspect of power line configuration shown to influence PWD accuracy was phase sequence on the power line circuit(s). Specific phase conductor arrangements and combinations, particularly in multiple circuit installations, resulted in either improved or degraded accuracy. JF - A Performance Evaluation of Two Overhead Power Line Proximity Warning Devices. [np]. Nov 2008. AU - Homce, G T AU - Cawley, J C AU - Yenchek, M R Y1 - 2008/11// PY - 2008 DA - Nov 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Risk Abstracts; Health & Safety Science Abstracts KW - safety systems KW - Degradation KW - Occupational safety KW - Electric fields KW - Mortality KW - Sensitivity KW - USA KW - safety engineering KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20144337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Risk+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Homce%2C+G+T%3BCawley%2C+J+C%3BYenchek%2C+M+R&rft.aulast=Homce&rft.aufirst=G&rft.date=2008-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Performance+Evaluation+of+Two+Overhead+Power+Line+Proximity+Warning+Devices&rft.title=A+Performance+Evaluation+of+Two+Overhead+Power+Line+Proximity+Warning+Devices&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Enhanced Microscopic Definition of Campylobacter jejuni 81-176 Adherence to, Invasion of, Translocation across, and Exocytosis from Polarized Human Intestinal Caco-2 Cells AN - 19686341; 8595848 AB - Campylobacter jejuni-mediated pathogenesis involves gut adherence and translocation across intestinal cells. The current study was undertaken to examine the C. jejuni interaction with and translocation across differentiated Caco-2 cells to better understand Campylobacter's pathogenesis. The efficiency of C. jejuni 81-176 invasion of Caco-2 cells was two- to threefold less than the efficiency of invasion of INT407 cells. Adherence-invasion analyses indicated that C. jejuni 81-176 adhered to most INT407 cells but invaded only about two-thirds of the host cells over 2 h (two bacteria/cell). In contrast, only 11 to 17% of differentiated Caco-2 cells were observed to bind and internalize either C. jejuni strain 81-176 or NCTC 11168, and a small percentage of infected Caco-2 cells contained 5 to 20 internalized bacteria per cell after 2 h. Electron microscopy revealed that individual C. jejuni cells adhered to the tips of host cell microvilli via intimate flagellar contacts and by lateral bacterial binding to the sides of microvilli. Next, bacteria were observed to bind at the apical host membrane surface via presumed interactions at one pole of the bacterium and with host membrane protrusions located near intercellular junctions. The latter contacts apparently resulted in coordinated, localized plasma membrane invagination, causing simultaneous internalization of bacteria into an endosome. Passage of this Campylobacter endosome intracellularly from the apical surface to the basolateral surface occurred over time, and bacterial release apparently resulted from endosome-basolateral membrane fusion (i.e., exocytosis). Bacteria were found intercellularly below tight junctions at 60 min postinfection, but not at earlier times. This study revealed unique host cell adherence contacts, early endocytosis-specific structures, and a presumptive exocytosis component of the transcellular transcytosis route. JF - Infection and Immunity AU - Hu, Lan AU - Tall, Ben D AU - Curtis, Sherill K AU - Kopecko, Dennis J AD - Laboratory of Enteric and Sexually Transmitted Diseases, FDA Center for Biologics Evaluation and Research, 29 Lincoln Drive, NIH Campus, Bldg. 29/420, Bethesda, Maryland 20892. FDA Center for Food Safety and Applied Nutrition, Laurel, Maryland 20708 Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 5294 EP - 5304 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 11 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Tight junctions KW - Membrane fusion KW - Exocytosis KW - Invaginations KW - endosomes KW - Digestive tract KW - Plasma membranes KW - Campylobacter jejuni KW - Intestine KW - Translocation KW - Electron microscopy KW - Flagella KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19686341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Enhanced+Microscopic+Definition+of+Campylobacter+jejuni+81-176+Adherence+to%2C+Invasion+of%2C+Translocation+across%2C+and+Exocytosis+from+Polarized+Human+Intestinal+Caco-2+Cells&rft.au=Hu%2C+Lan%3BTall%2C+Ben+D%3BCurtis%2C+Sherill+K%3BKopecko%2C+Dennis+J&rft.aulast=Hu&rft.aufirst=Lan&rft.date=2008-11-01&rft.volume=76&rft.issue=11&rft.spage=5294&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - endosomes; Digestive tract; Plasma membranes; Tight junctions; Membrane fusion; Intestine; Exocytosis; Invaginations; Translocation; Electron microscopy; Flagella; Campylobacter jejuni ER - TY - JOUR T1 - Porcine endogenous retroviruses and xenotransplantation AN - 19664770; 8892413 AB - Xenotransplantation is defined by the PHS as any procedure that involves the transplantation, implantation or infusion into a human recipient of either (a) live cells, tissues or organs from a nonhuman animal source, or (b) human body fluids, cells, tissues or organs that have had ex vivo contact with live nonhuman animal cells, tissues or organs (Public Health Service Guideline on Infectious Disease Issues in Xenotransplantation). Use of pigs for human xenotransplantation raises concerns about the risks of transfer of infectious agents from the pig cells to xenotransplantation recipients. The observation that the porcine germline harbors genetic loci encoding porcine endogenous retroviruses (PERVs) that are in some cases infectious for human cells has resulted in renewed scientific interest in PERVs. However, in spite of the past 10 years of investigation, the actual risk for PERV infection, replication, and pathogenic outcome in human recipients of xenotransplantation products is still undefined. JF - Cellular and Molecular Life Sciences AU - Wilson, CA AD - Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissues, and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Building 29B, Rm 5NN20, Bethesda, MD 20892 (USA), Carolyn.wilson@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 3399 EP - 3412 VL - 65 IS - 21 SN - 1420-682X, 1420-682X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Retrovirus KW - Infectious diseases KW - Replication KW - Xenografts KW - Infection KW - Body fluids KW - Public health KW - V 22320:Replication KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19664770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Life+Sciences&rft.atitle=Porcine+endogenous+retroviruses+and+xenotransplantation&rft.au=Wilson%2C+CA&rft.aulast=Wilson&rft.aufirst=CA&rft.date=2008-11-01&rft.volume=65&rft.issue=21&rft.spage=3399&rft.isbn=&rft.btitle=&rft.title=Cellular+and+Molecular+Life+Sciences&rft.issn=1420682X&rft_id=info:doi/10.1007%2Fs00018-008-8498-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Infectious diseases; Replication; Xenografts; Infection; Body fluids; Public health; Retrovirus DO - http://dx.doi.org/10.1007/s00018-008-8498-z ER - TY - JOUR T1 - Should Health-Care Providers in the United States Have Access to Influenza Vaccines Formulated for the Southern Hemisphere? AN - 19633973; 8822537 AB - BackgroundInfluenza is the most common vaccine-preventable disease in travelers. It circulates year-round in the tropics, November to March in the northern hemisphere (NH), and April to October in the southern hemisphere (SH). In 2005, approximately 8.5 million US adults aged 18 years and older traveled to the Caribbean. A similar number traveled to the tropics and the SH. SH formulation of influenza vaccine is not available in the United States. We surveyed International Society of Travel Medicine (ISTM) members to ask if they would use SH influenza vaccine if available. MethodsWe electronically mailed a survey in December 2006 to 1,251 ISTM members in the United States. We asked if respondents would use SH vaccine for patients traveling to the SH or tropics, how many such patients per week they see, and their practice location. ResultsWe received 157 responses for a response rate of 12.5%. Of these, 129 (82%) stated that they would be interested in having SH influenza vaccine available. Of those indicating interest, 73 (60%) reported seeing >10 patients traveling to the SH or tropics each week. Respondents reported practice settings in 34 states and the District of Columbia. Respondents requested more information about the likely cost of SH influenza vaccine, ordering conditions, vaccine use guidelines, comparability with NH vaccine, and approval of SH vaccine by the Food and Drug Administration. ConclusionsMany travelers to the SH are at risk for influenza infection. Although only a limited number of ISTM members responded, respondents indicated considerable interest in availability of SH influenza vaccine for their patients. More data from travel medicine and other practitioners are needed on this topic. Inquiries are being made of influenza vaccine manufacturers about licensing SH influenza vaccines in the United States. Adding SH influenza vaccine to the vaccines available to NH clinicians could help mitigate the morbidity of influenza in travelers. JF - Journal of Travel Medicine AU - Strikas, Raymond A AU - Kozarsky, Phyllis E AU - Reed, Christie AU - Kapella, Brian K AU - Freedman, David O AD - National Vaccine Program Office, Department of Health and Human Services, Washington, DC, USA, raymond.strikas@psc.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 442 EP - 446 PB - BC Decker Inc, 20 Hughson Street South VL - 15 IS - 6 SN - 1195-1982, 1195-1982 KW - Risk Abstracts KW - Travel KW - vaccines KW - Licensing KW - Morbidity KW - influenza KW - USA KW - ASW, Caribbean Sea KW - guidelines KW - Tropical environments KW - infection KW - Drugs KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19633973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Travel+Medicine&rft.atitle=Should+Health-Care+Providers+in+the+United+States+Have+Access+to+Influenza+Vaccines+Formulated+for+the+Southern+Hemisphere%3F&rft.au=Strikas%2C+Raymond+A%3BKozarsky%2C+Phyllis+E%3BReed%2C+Christie%3BKapella%2C+Brian+K%3BFreedman%2C+David+O&rft.aulast=Strikas&rft.aufirst=Raymond&rft.date=2008-11-01&rft.volume=15&rft.issue=6&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Journal+of+Travel+Medicine&rft.issn=11951982&rft_id=info:doi/10.1111%2Fj.1708-8305.2008.00254.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; ASW, Caribbean Sea; vaccines; influenza; Tropical environments; Travel; Morbidity; Licensing; guidelines; infection; Drugs DO - http://dx.doi.org/10.1111/j.1708-8305.2008.00254.x ER - TY - JOUR T1 - Diffusion behaviour of additives in polypropylene in correlation with polymer properties AN - 19617966; 8681947 AB - The migration behaviour of polymer additives in 17 polypropylene (PP) samples is described. These samples cover the major types of PP used in food packaging. The diffusion coefficients of additives with relatively small molecular masses, Mr = 136 (limonene), as well as the migration of typical antioxidants used in PP up to Mr = 1178 (IRGANOX 1010), were measured at different temperatures. In addition, the diffusion data and percentages of xylene-soluble fractions were correlated. This enables a prediction of the migration behaviour of a PP sample by testing its 'isotactic index' with xylene. The results clearly indicate that PP can be subdivided, from the migration point of view, into the monophasic homopolymer (h-PP), the monophasic random copolymer (r-PP), and the heterophasic copolymer (heco-PP). The diffusion coefficients for r-PP are at least one order of magnitude higher than those of h-PP and comparable with the values for heco-PP. Upper limits for the diffusion values can be calculated based on the safety margin required by consumer protection laws. JF - Food Additives & Contaminants Part A Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Begley, T H AU - Brandsch, J AU - Limm, W AU - Siebert, H AU - Piringer, O AD - US Food and Drug Administration, Centre for Food Safety & Applied Nutrition (CFSAN), College Park, MD, USA Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1409 EP - 1415 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 25 IS - 11 SN - 0265-203X, 0265-203X KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Antioxidants KW - Migration KW - Food additives KW - Xylene KW - Diffusion KW - Packaging KW - migration KW - Temperature KW - Food contamination KW - Consumer protection KW - consumer protection KW - Polymers KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19617966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Diffusion+behaviour+of+additives+in+polypropylene+in+correlation+with+polymer+properties&rft.au=Begley%2C+T+H%3BBrandsch%2C+J%3BLimm%2C+W%3BSiebert%2C+H%3BPiringer%2C+O&rft.aulast=Begley&rft.aufirst=T&rft.date=2008-11-01&rft.volume=25&rft.issue=11&rft.spage=1409&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=0265203X&rft_id=info:doi/10.1080%2F02652030802162747 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diffusion; Migration; Food contamination; Polymers; Food additives; Packaging; Risk assessment; Xylene; Antioxidants; Consumer protection; Temperature; migration; consumer protection DO - http://dx.doi.org/10.1080/02652030802162747 ER - TY - JOUR T1 - The safety of post-exposure vaccination of mice infected with Mycobacterium tuberculosis AN - 19615165; 8604365 AB - New post-exposure tuberculosis vaccination strategies are being developed to prevent disease in individuals latently infected with Mycobacterium tuberculosis. However, concerns about the potential induction of deleterious Koch-like reactions after immunization of persons with latent tuberculosis has limited progress in assessing the effectiveness of post-exposure vaccination. To evaluate the safety of immunization after M. tuberculosis infection, two mouse models were established, a drug treatment low bacterial burden model and an active disease model. Twelve different M. tuberculosis antigen preparations and vaccines (including DNA, subunit, viral vectored, and live, attenuated vaccines) were evaluated using these mouse models. In the low bacterial burden model, post-exposure vaccination did not induce significant reactivational disease and only injection of BCG evoked increases in lung inflammatory responses at 1 month after the immunizations. Additionally, although significant increases in lung inflammation were seen for animals injected with the hps65 DNA vaccine or a M. tuberculosis culture supernatant preparation, no differences in the survival periods were detected between vaccinated and non-vaccinated mice at 10 months post-immunization using the low bacterial burden model. For the active disease model, significantly more lung inflammation was observed at 1 month after administration of the hsp65 DNA vaccine but none of the antigen preparations tested increased the lung bacterial burdens at this early time point. Furthermore, vaccination of diseased mice with BCG or TB DNA vaccines did not significantly affect mortality rates compared to non-vaccinated controls at 10 months post-immunization. Overall, these data suggest that while the potential risk of inducing Koch-like reactions is low after immunization of persons with latent tuberculosis, extreme caution is still needed as post-exposure vaccines progress from pre-clinical experiments into the initial phases of clinical testing. JF - Vaccine AU - Derrick, Steven C AU - Perera, L P AU - Dheenadhayalan, Veerabadran AU - Yang, Amy AU - Kolibab, Kristopher AU - Morris, Sheldon L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, United States, steven.derrick@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 6092 EP - 6098 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 48 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Tuberculosis KW - Vaccine KW - Safety KW - Latent infection KW - Mortality KW - Heat shock proteins KW - Data processing KW - Animal models KW - Survival KW - Infection KW - Hsp65 protein KW - Inflammation KW - DNA vaccines KW - Lung KW - BCG KW - Drugs KW - Mycobacterium tuberculosis KW - V 22410:Animal Diseases KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19615165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=The+safety+of+post-exposure+vaccination+of+mice+infected+with+Mycobacterium+tuberculosis&rft.au=Derrick%2C+Steven+C%3BPerera%2C+L+P%3BDheenadhayalan%2C+Veerabadran%3BYang%2C+Amy%3BKolibab%2C+Kristopher%3BMorris%2C+Sheldon+L&rft.aulast=Derrick&rft.aufirst=Steven&rft.date=2008-11-01&rft.volume=26&rft.issue=48&rft.spage=6092&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.09.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Latent infection; Heat shock proteins; Data processing; Animal models; Survival; Hsp65 protein; Infection; Inflammation; DNA vaccines; BCG; Lung; Tuberculosis; Drugs; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1016/j.vaccine.2008.09.011 ER - TY - JOUR T1 - Engineering Case Reports AN - 19605804; 8502109 AB - Abstract not available. JF - Journal of Occupational and Environmental Hygiene AU - Old, Leo AU - Dunn, Kevin H AU - Garcia, Alberto AU - Echt, Alan AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - D103 EP - D110 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 11 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts KW - Safety engineering KW - Occupational safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19605804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Engineering+Case+Reports&rft.au=Old%2C+Leo%3BDunn%2C+Kevin+H%3BGarcia%2C+Alberto%3BEcht%2C+Alan&rft.aulast=Old&rft.aufirst=Leo&rft.date=2008-11-01&rft.volume=5&rft.issue=11&rft.spage=D103&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802363274 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Safety engineering; Occupational safety DO - http://dx.doi.org/10.1080/15459620802363274 ER - TY - JOUR T1 - Enumeration of Mycobacterium leprae Using Real-Time PCR AN - 19568913; 8819512 AB - Mycobacterium leprae is not cultivable in axenic media, and direct microscopic enumeration of the bacilli is complex, labor intensive, and suffers from limited sensitivity and specificity. We have developed a real-time PCR assay for quantifying M. leprae DNA in biological samples. Primers were identified to amplify a shared region of the multicopy repeat sequence (RLEP) specific to M. leprae and tested for sensitivity and specificity in the TaqMan format. The assay was specific for M. leprae and able to detect 10 fg of purified M. leprae DNA, or approximately 300 bacteria in infected tissues. We used the RLEP TaqMan PCR to assess the short and long-term growth results of M. leprae in foot pad tissues obtained from conventional mice, a gene knock-out mouse strain, athymic nude mice, as well as from reticuloendothelial tissues of M. leprae-infected nine-banded armadillos. We found excellent correlative results between estimates from RLEP TaqMan PCR and direct microscopic counting (combined r=0.98). The RLEP TaqMan PCR permitted rapid analysis of batch samples with high reproducibility and is especially valuable for detection of low numbers of bacilli. Molecular enumeration is a rapid, objective and highly reproducible means to estimate the numbers of M. leprae in tissues, and application of the technique can facilitate work with this agent in many laboratories. Author Summary Mycobacterium leprae is not cultivable in axenic media, and direct microscopic enumeration of the bacilli is complex, labor intensive, and suffers from limited sensitivity and specificity. We describe the use of real-time PCR to provide a rapid, objective and consistent enumeration procedure for M. leprae. The procedure is specific for M. leprae, has a dynamic range of approximately 6 logs and yields results in only a few hours, including processing time. The procedure was applied to M. leprae growing in mouse and armadillo tissues showing excellent correlation with microscopic counting. The benefits of this technique for experimental characterization of leprosy infections and vaccine trials are substantial, and potential applications to clinical specimens could impact patient management by simplifying the assessment of bacterial burden prior to and during drug treatment. JF - PLoS Neglected Tropical Diseases AU - Truman, Richard W AU - Andrews, PKyle AU - Robbins, Naoko Y AU - Adams, Linda B AU - Krahenbuhl, James L AU - Gillis, Thomas P AU - Small, Pamela LC AD - Department of Health and Human Services, Health Resources Services Administration, Bureau of Primary Health Care, National Hansen's Disease Programs, Baton Rouge, Louisiana, United States of America Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 2 IS - 11 SN - 1935-2727, 1935-2727 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacilli KW - Mycobacterium leprae KW - Enumeration KW - Infection KW - Clinical trials KW - Leprosy KW - Foot KW - Polymerase chain reaction KW - Primers KW - Vaccines KW - Armadillo KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19568913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Enumeration+of+Mycobacterium+leprae+Using+Real-Time+PCR&rft.au=Truman%2C+Richard+W%3BAndrews%2C+PKyle%3BRobbins%2C+Naoko+Y%3BAdams%2C+Linda+B%3BKrahenbuhl%2C+James+L%3BGillis%2C+Thomas+P%3BSmall%2C+Pamela+LC&rft.aulast=Truman&rft.aufirst=Richard&rft.date=2008-11-01&rft.volume=2&rft.issue=11&rft.spage=e328&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0000328 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bacilli; Foot; Polymerase chain reaction; Primers; Vaccines; Enumeration; Infection; Drugs; Clinical trials; Leprosy; Mycobacterium leprae; Armadillo DO - http://dx.doi.org/10.1371/journal.pntd.0000328 ER - TY - JOUR T1 - US Food and Drug Administration's Total Diet Study: Dietary intake of perchlorate and iodine AN - 19565928; 8831613 AB - The US Food and Drug Administration (FDA) has conducted the Total Diet Study (TDS) since 1961, which designed to monitor the US food supply for chemical contaminants, nutritional elements, and toxic elements. Recently, perchlorate was analyzed in TDS samples. Perchlorate is used as an oxidizing agent in rocket propellant, is found in other items (e.g., explosives, road flares, fireworks, and car airbags), occurs naturally in some fertilizers, and may be generated under certain climatic conditions. It has been detected in surface and groundwater and in food. Perchlorate at high (e.g., pharmacological) doses can interfere with iodide uptake into the thyroid gland, disrupting its function. The National Academy of Sciences (NAS) has identified that "the fetuses of pregnant women who might have hypothyroidism or iodide deficiency as the most sensitive population." This study reports on intake estimates of perchlorate and iodine, a precursor to iodide, using the analytical results from the TDS. Estimated average perchlorate and iodine daily intakes as well as the contribution of specific food groups to total intakes were estimated for 14 age/sex subgroups of the US population. The estimated smallest lower bound to the largest upper bound average perchlorate intakes by the 14 age/sex groups range from 0.08 to 0.39 micrograms per kilogram body weight per day ( mu g/kg bw/day), compared with the US Environmental Protection Agency (EPA) reference dose (RfD) of 0.7 mu g/kg bw/day. Infants and children demonstrated the highest estimated intakes of perchlorate on a body weight basis. The estimated average iodine intakes by the 14 age/sex groups reveal a lower bound (ND=o) and upper bound (ND=LOD) range of average intakes from 138 to 353 mu g/person/day. Estimated iodine intakes by infants 6-11 months exceed their adequate intake (AI), and intakes by children and adult age/sex groups exceed their relevant estimated average requirement (EAR). JF - Journal of Exposure Science and Environmental Epidemiology AU - Murray, C W AU - Egan, S K AU - Kim, H AU - Beru, N AU - Bolger, P M AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, HFS-301, College Park, MD 20740-3835, USA, Clarence.Murray@fda.hhs.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 571 EP - 580 VL - 18 IS - 6 SN - 1559-0631, 1559-0631 KW - Pollution Abstracts KW - Age KW - Propellants KW - Fertilizers KW - Iodine KW - body weight KW - Drugs KW - Diets KW - age groups KW - iodides KW - Thyroid KW - Ingestion KW - Children KW - perchlorate KW - Pregnancy KW - EPA KW - USA KW - FDA KW - Explosives KW - Air bags KW - Infants KW - P 2000:FRESHWATER POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19565928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=US+Food+and+Drug+Administration%27s+Total+Diet+Study%3A+Dietary+intake+of+perchlorate+and+iodine&rft.au=Murray%2C+C+W%3BEgan%2C+S+K%3BKim%2C+H%3BBeru%2C+N%3BBolger%2C+P+M&rft.aulast=Murray&rft.aufirst=C&rft.date=2008-11-01&rft.volume=18&rft.issue=6&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fsj.jes.7500648 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diets; age groups; Age; iodides; Propellants; Thyroid; Children; Ingestion; perchlorate; Pregnancy; EPA; Fertilizers; FDA; Iodine; Explosives; Air bags; Drugs; body weight; Infants; USA DO - http://dx.doi.org/10.1038/sj.jes.7500648 ER - TY - JOUR T1 - Inactivation of Escherichia coli O157:H7, Salmonella typhimurium, and Listeria monocytogenes on Stored Iceberg Lettuce by Aqueous Chlorine Dioxide Treatment AN - 19559000; 8783775 AB - Inactivation of Escherichia coli O157:H7, Salmonella typhimurium, and Listeria monocytogenes in iceberg lettuce by aqueous chlorine dioxide (ClO sub(2)) treatment was evaluated. Iceberg lettuce samples were inoculated with approximately 7 log CFU-g of E. coli O157:H7, S. typhimurium, and L. monocytogenes. Iceberg lettuce samples were then treated with 0, 5, 10, or 50 ppm ClO sub(2) solution and stored at 4 degree C. Aqueous ClO sub(2) treatment significantly decreased the populations of pathogenic bacteria on shredded lettuce (P < 0.05). In particular, 50 ppm ClO sub(2) treatment reduced E. coli O157:H7, S. typhimurium, and L. monocytogenes by 1.44, 1.95, and 1.20 log CFU-g, respectively. The D sub(10)-values of E. coli O157:H7, S. typhimurium, and L. monocytogenes in shredded lettuce were 11, 26, and 42 ppm, respectively. The effect of aqueous ClO sub(2) treatment on the growth of pathogenic bacteria during storage was evaluated, and a decrease in the population size of these pathogenic bacteria was observed. Additionally, aqueous ClO sub(2) treatment did not affect the color of lettuce during storage. These results suggest that aqueous ClO sub(2) treatment can be used to improve the microbial safety of shredded lettuce during storage. JF - Journal of Food Science AU - Kim, Yun-Jung AU - Lee, Seung-Hwan AU - Park, Jiyong AU - Park, Jonghyun AU - Chung, Myongsoo AU - Kwon, Kisung AU - Chung, Kyungsook AU - Won, Misun AU - Song, Kyung Bin AD - Authors Yun-Jung Kim, Seung-Hwan Lee, and Kyung Bin Song are with Dept. of Food Science and Technology, Chungnam National Univ., Daejeon, 305-764, Korea. Author Jiyong Park is with Dept. of Biotechnology, Yonsei Univ., Seoul, 120-749, Korea. Author Jonghyun Park is with Dept. of Food Science and Biotechnology, Kyungwon Univ., Sungnam, 461-701, Korea. Author Myongsoo Chung is with Dept. of Food Science, Ehwa Women's Univ., Seoul, 120-750, Korea. Author Kisung Kwon is with Center for Food Safety Evaluation, Korea Food and Drug Administration, Seoul, 122-704, Korea. Authors Kyungsook Chung and Misun Won are with Korea Research Inst. of Bioscience and Biotechnology, Daejeon, 305-806, Korea. Direct inquiries to author Kyung Bin Song ( Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - M418 EP - M422 PB - Institute of Food Technology VL - 73 IS - 9 SN - 0022-1147, 0022-1147 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - aqueous chlorine dioxide KW - D-value KW - iceberg lettuce KW - microbial growth KW - storage KW - Listeria monocytogenes KW - Chlorine dioxide KW - Icebergs KW - Escherichia coli KW - Salmonella typhimurium KW - Color KW - A 01330:Food Microbiology KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19559000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Inactivation+of+Escherichia+coli+O157%3AH7%2C+Salmonella+typhimurium%2C+and+Listeria+monocytogenes+on+Stored+Iceberg+Lettuce+by+Aqueous+Chlorine+Dioxide+Treatment&rft.au=Kim%2C+Yun-Jung%3BLee%2C+Seung-Hwan%3BPark%2C+Jiyong%3BPark%2C+Jonghyun%3BChung%2C+Myongsoo%3BKwon%2C+Kisung%3BChung%2C+Kyungsook%3BWon%2C+Misun%3BSong%2C+Kyung+Bin&rft.aulast=Kim&rft.aufirst=Yun-Jung&rft.date=2008-11-01&rft.volume=73&rft.issue=9&rft.spage=M418&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2Fj.1750-3841.2008.00940.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chlorine dioxide; Icebergs; Color; Listeria monocytogenes; Escherichia coli; Salmonella typhimurium DO - http://dx.doi.org/10.1111/j.1750-3841.2008.00940.x ER - TY - JOUR T1 - Transient Exposure to Transforming Growth Factor Beta 3 Under Serum-Free Conditions Enhances the Biomechanical and Biochemical Maturation of Tissue-Engineered Cartilage AN - 19512613; 8833721 AB - A goal of cartilage tissue engineering is the production of cell-laden constructs possessing sufficient mechanical and biochemical features to enable native tissue function. This study details a systematic characterization of a serum-free (SF) culture methodology employing transient growth factor supplementation to promote robust maturation of tissue-engineered cartilage. Bovine chondrocyte agarose hydrogel constructs were cultured under free-swelling conditions in serum-containing or SF medium supplemented continuously or transiently with varying doses of transforming growth factor beta 3 (TGF- beta 3). Constructs were harvested weekly or bi-weekly and assessed for mechanical and biochemical properties. Transient exposure (2 weeks) to low concentrations (2.5-5 ng/mL) of TGF- beta 3 in chemically defined medium facilitated robust and highly reproducible construct maturation. Constructs receiving transient TGF- beta 3 exposure achieved native tissue levels of compressive modulus (0.8 MPa) and proteoglycan content (6-7% of wet weight) after less than 2 months of in vitro culture. This maturation response was far superior to that observed after continuous growth factor supplementation or transient TGF- beta 3 treatment in the presence of serum. These findings represent a significant advance in developing an ex vivo culture methodology to promote production of clinically relevant and mechanically competent tissue-engineered cartilage constructs for implantation to repair damaged articular surfaces. JF - Tissue Engineering, Part A: Tissue Engineering AU - Byers, BA AU - Mauck, R L AU - Chiang, I E AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, 50 South Drive, Building 50, Room 1503, MSC 8022, Bethesda, MD 20892, USA, tuanr@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1821 EP - 1834 VL - 14 IS - 11 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - Proteoglycans KW - hydrogels KW - Cartilage KW - Chondrocytes KW - Transforming growth factor-^b KW - Cell culture KW - Tissue engineering KW - Supplementation KW - Transforming growth factor-^b1 KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19512613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Transient+Exposure+to+Transforming+Growth+Factor+Beta+3+Under+Serum-Free+Conditions+Enhances+the+Biomechanical+and+Biochemical+Maturation+of+Tissue-Engineered+Cartilage&rft.au=Byers%2C+BA%3BMauck%2C+R+L%3BChiang%2C+I+E%3BTuan%2C+R+S&rft.aulast=Byers&rft.aufirst=BA&rft.date=2008-11-01&rft.volume=14&rft.issue=11&rft.spage=1821&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2007.0222 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Tissue engineering; Transforming growth factor-^b; Cartilage; Cell culture; Transforming growth factor-^b1; Supplementation; Proteoglycans; Chondrocytes; hydrogels DO - http://dx.doi.org/10.1089/ten.tea.2007.0222 ER - TY - JOUR T1 - Determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in food and paper packaging materials from US marketplaces AN - 19335412; 8681948 AB - A gas chromatography-ion-trap tandem mass spectrometry procedure was developed for the determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in domestic and imported paper packages and food sold in US marketplaces. The procedure involved ultrasonic extraction with dichloromethane, followed by analysis with the gas chromatography-ion-trap tandem mass spectrometry. Calibration curves for DIPN and DBP were achieved with concentrations ranging from 0.01 to 10 mg ml-1 and the corresponding r2 values were 0.9976 and 0.9956, respectively. In most of the fortified samples the recoveries were higher than 80% with a relative standard deviation (RSD) <10%. Using this procedure, it was found that less than 20% of the tested domestic packages and more than 60% of the tested imported food packages contained both DIPN and DBP. The concentrations of DIPN and DBP ranged from 0.09 to 20 mg kg-1 and 0.14 to 55 mg kg-1, respectively, with most of the DINP and DBP levels lower than 20 mg kg-1. DIPN was not detected (<0.01 mg kg-1) in 41 food samples and DBP was only detected in two domestic and four imported food samples with concentrations ranging from <0.01 to 0.81 mg kg-1. JF - Food Additives & Contaminants Part A Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Zhang, K AU - Noonan, G O AU - Begley, T H AD - US Food and Drug Administration, Centre for Food Safety & Applied Nutrition (CFSAN), MD, USA Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1416 EP - 1423 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 25 IS - 11 SN - 0265-203X, 0265-203X KW - Risk Abstracts KW - Risk assessment KW - Food additives KW - USA KW - Ultrasonics KW - Mass spectrometry KW - packaging materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19335412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Determination+of+2%2C6-diisopropylnaphthalene+%28DIPN%29+and+n-dibutylphthalate+%28DBP%29+in+food+and+paper+packaging+materials+from+US+marketplaces&rft.au=Zhang%2C+K%3BNoonan%2C+G+O%3BBegley%2C+T+H&rft.aulast=Zhang&rft.aufirst=K&rft.date=2008-11-01&rft.volume=25&rft.issue=11&rft.spage=1416&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=0265203X&rft_id=info:doi/10.1080%2F02652030802163380 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Mass spectrometry; Ultrasonics; Risk assessment; Food additives; packaging materials DO - http://dx.doi.org/10.1080/02652030802163380 ER - TY - JOUR T1 - Toll-free number for reporting adverse events on labeling for human drug products. Final rule. AN - 69923263; 19112682 AB - The Food and Drug Administration (FDA) is issuing a final rule that confirms the interim final rule entitled "Toll-Free Number for Reporting Adverse Events on Labeling for Human Drug Products" (73 FR 402, January 3, 2008) (interim final rule) and responds to comments submitted in response to the request for comments in the proposed rule of the same title (69 FR 21778, April 22, 2004) (proposed rule). This final rule affirms the interim final rule's requirement for the addition of a statement to the labeling for certain human drug products for which an application is approved under section 505 of the Federal Food, Drug, and Cosmetic Act (the act). The statement includes a toll-free number and advises that the number is to be used only for reporting side effects and is not intended for medical advice (the side effects statement). This final rule also affirms the interim final rule's addition of new part 209 to the regulations requiring distribution of the side effects statement. This final rule implements provisions of the Best Pharmaceuticals for Children Act (the BPCA) and the Food and Drug Administration Amendments Act of 2007 (FDAAA). JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2008/10/28/ PY - 2008 DA - 2008 Oct 28 SP - 63886 EP - 63897 VL - 73 IS - 209 SN - 0097-6326, 0097-6326 KW - Prescription Drugs KW - 0 KW - Health technology assessment KW - United States KW - Humans KW - Adverse Drug Reaction Reporting Systems -- legislation & jurisprudence KW - Drug Labeling -- legislation & jurisprudence KW - Hotlines -- legislation & jurisprudence KW - Drug Industry -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69923263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Toll-free+number+for+reporting+adverse+events+on+labeling+for+human+drug+products.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2008-10-28&rft.volume=73&rft.issue=209&rft.spage=63886&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-02 N1 - Date created - 2008-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - National Estimate of Workers Exposed to Hazardous Workplace Noise --- United States, 1999--2004 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41871865; 5070260 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Tak, SangWoo AU - Calvert, Geoffrey Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Noise levels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41871865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=National+Estimate+of+Workers+Exposed+to+Hazardous+Workplace+Noise+---+United+States%2C+1999--2004&rft.au=Tak%2C+SangWoo%3BCalvert%2C+Geoffrey&rft.aulast=Tak&rft.aufirst=SangWoo&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regional collaboration on a Shigellosis issue T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41864467; 5069270 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Thorne, Brenda AU - Slentz, Monica AU - Martinez, Diana AU - Kilborn, Cindy AU - Lin, Huai AU - Short, Kirstin AU - Awosika-Olumo, Adebowale AU - Partridge, Christa AU - Beckham, Dana AU - Cuellar, Sandra AU - Valcin, Randy AU - Prejean, Jan Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Shigellosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Regional+collaboration+on+a+Shigellosis+issue&rft.au=Thorne%2C+Brenda%3BSlentz%2C+Monica%3BMartinez%2C+Diana%3BKilborn%2C+Cindy%3BLin%2C+Huai%3BShort%2C+Kirstin%3BAwosika-Olumo%2C+Adebowale%3BPartridge%2C+Christa%3BBeckham%2C+Dana%3BCuellar%2C+Sandra%3BValcin%2C+Randy%3BPrejean%2C+Jan&rft.aulast=Thorne&rft.aufirst=Brenda&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using the Environmental Public Health Performance Standards to improve environmental health infrastructure and services to tribal communities T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41863862; 5069091 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Davis, Celeste Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Public health KW - Infrastructure KW - Environmental health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41863862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Using+the+Environmental+Public+Health+Performance+Standards+to+improve+environmental+health+infrastructure+and+services+to+tribal+communities&rft.au=Davis%2C+Celeste&rft.aulast=Davis&rft.aufirst=Celeste&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of question type, reference period and sensitivity on item reliability in the National Survey on Drug Use and Health T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41863335; 5070710 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Kennet, Joel AU - Painter, Dicy AU - Feder, Moshe AU - Snodgrass, Jeanne AU - Piper, Lanny Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Sensitivity KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41863335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Influence+of+question+type%2C+reference+period+and+sensitivity+on+item+reliability+in+the+National+Survey+on+Drug+Use+and+Health&rft.au=Kennet%2C+Joel%3BPainter%2C+Dicy%3BFeder%2C+Moshe%3BSnodgrass%2C+Jeanne%3BPiper%2C+Lanny&rft.aulast=Kennet&rft.aufirst=Joel&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 2006 HIV incidence and prevalence in Houston/Harris County, TX T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41861538; 5067059 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Yang, Biru AU - Chan, Shirley AU - Mohammad, Naqi AU - Wolverton, Marcia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA, Texas, Houston KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=2006+HIV+incidence+and+prevalence+in+Houston%2FHarris+County%2C+TX&rft.au=Yang%2C+Biru%3BChan%2C+Shirley%3BMohammad%2C+Naqi%3BWolverton%2C+Marcia&rft.aulast=Yang&rft.aufirst=Biru&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of chronic obstructive pulmonary disease in the U.S. working population: A study of the 1997-2004 National Health Interview Survey data T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41854038; 5070262 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Bang, Ki AU - Syamlal, Girija AU - Mazurek, Jacek Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Chronic obstructive pulmonary disease KW - Data processing KW - Population studies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Prevalence+of+chronic+obstructive+pulmonary+disease+in+the+U.S.+working+population%3A+A+study+of+the+1997-2004+National+Health+Interview+Survey+data&rft.au=Bang%2C+Ki%3BSyamlal%2C+Girija%3BMazurek%2C+Jacek&rft.aulast=Bang&rft.aufirst=Ki&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two norovirus outbreaks: Same nurse manager, different outcomes T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41854017; 5069427 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Long, Stephen AU - Zhang, Yufang AU - Thorne, Brenda AU - Awosika-Olumo, Adebowale Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Nursing KW - Outbreaks KW - Medical personnel KW - Norovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Two+norovirus+outbreaks%3A+Same+nurse+manager%2C+different+outcomes&rft.au=Long%2C+Stephen%3BZhang%2C+Yufang%3BThorne%2C+Brenda%3BAwosika-Olumo%2C+Adebowale&rft.aulast=Long&rft.aufirst=Stephen&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multivariate analysis of state variation in underinsurance among children with special health care needs in the US, 2005-06 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41851885; 5067369 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Kogan, Michael AU - Newacheck, Paul AU - Strickland, Bonnie AU - Blumberg, Stephen AU - Singh, Gopal AU - Zeni, Mary AU - Honberg, Lynda AU - Free, Heather AU - Heyman, Kathleen Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Children KW - Health care KW - Multivariate analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Multivariate+analysis+of+state+variation+in+underinsurance+among+children+with+special+health+care+needs+in+the+US%2C+2005-06&rft.au=Kogan%2C+Michael%3BNewacheck%2C+Paul%3BStrickland%2C+Bonnie%3BBlumberg%2C+Stephen%3BSingh%2C+Gopal%3BZeni%2C+Mary%3BHonberg%2C+Lynda%3BFree%2C+Heather%3BHeyman%2C+Kathleen&rft.aulast=Kogan&rft.aufirst=Michael&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IRB panel members perceptions of their role in the review of scientific methodology: A qualitative study T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41851827; 5070839 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Gellar, Lauren AU - Candilis, Philip AU - Garverich, Suzanne AU - Jackson, Christopher AU - Lidz, Chuck AU - Roach, Teresa Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Reviews KW - Perception KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=IRB+panel+members+perceptions+of+their+role+in+the+review+of+scientific+methodology%3A+A+qualitative+study&rft.au=Gellar%2C+Lauren%3BCandilis%2C+Philip%3BGarverich%2C+Suzanne%3BJackson%2C+Christopher%3BLidz%2C+Chuck%3BRoach%2C+Teresa&rft.aulast=Gellar&rft.aufirst=Lauren&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.htmlhttp://www.tms. org/Meetings/Annual-09/PDFs/AM09finalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigation of a Potential Mass Rabies Exposure T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41849323; 5069327 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Short, Kirstin AU - Persse, David AU - Awosika-Olumo, Adebowale AU - Ramon, Melanie AU - Grunenwald, Paul AU - Johnson, Gary Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Rabies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Investigation+of+a+Potential+Mass+Rabies+Exposure&rft.au=Short%2C+Kirstin%3BPersse%2C+David%3BAwosika-Olumo%2C+Adebowale%3BRamon%2C+Melanie%3BGrunenwald%2C+Paul%3BJohnson%2C+Gary&rft.aulast=Short&rft.aufirst=Kirstin&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Applications of American Time Use Survey to worker safety and health T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41848881; 5069760 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Chen, Guang Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Health and safety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Applications+of+American+Time+Use+Survey+to+worker+safety+and+health&rft.au=Chen%2C+Guang&rft.aulast=Chen&rft.aufirst=Guang&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Potentially productive years of life lost due to pneumoconiosis mortality in the United States, 1968-2004 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41848767; 5067789 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Mazurek, Jacek AU - Wood, John Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Pneumoconiosis KW - Mortality KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Potentially+productive+years+of+life+lost+due+to+pneumoconiosis+mortality+in+the+United+States%2C+1968-2004&rft.au=Mazurek%2C+Jacek%3BWood%2C+John&rft.aulast=Mazurek&rft.aufirst=Jacek&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An innovative method used to improve birh disparities among women of color T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41848636; 5070072 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Patterson, Pam AU - Mitchell, Carolyn Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Color KW - Methodology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=An+innovative+method+used+to+improve+birh+disparities+among+women+of+color&rft.au=Patterson%2C+Pam%3BMitchell%2C+Carolyn&rft.aulast=Patterson&rft.aufirst=Pam&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy People 2020: Preview the next decade's national objectives T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41846644; 5065146 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Royall, Penelope AU - Blakey, Carter AU - Horton, Mark Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Healthy+People+2020%3A+Preview+the+next+decade%27s+national+objectives&rft.au=Royall%2C+Penelope%3BBlakey%2C+Carter%3BHorton%2C+Mark&rft.aulast=Royall&rft.aufirst=Penelope&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Massachusetts Mental Health / Criminal Justice Cohort Study: What We've Learned T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41843656; 5067787 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Fisher, William AU - Roy-Bujnowski, Kristen AU - Banks, Steven AU - Grudzinskas, Albert AU - Simon, Lorna AU - Clayfield, Jonathan AU - Wolff, Nancy Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA, Massachusetts KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41843656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Massachusetts+Mental+Health+%2F+Criminal+Justice+Cohort+Study%3A+What+We%27ve+Learned&rft.au=Fisher%2C+William%3BRoy-Bujnowski%2C+Kristen%3BBanks%2C+Steven%3BGrudzinskas%2C+Albert%3BSimon%2C+Lorna%3BClayfield%2C+Jonathan%3BWolff%2C+Nancy&rft.aulast=Fisher&rft.aufirst=William&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Introduction to and overview of SAMHSA and CSAT's Screening, Brief Intervention and Referral to Treatment initiative T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41842460; 5068861 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Stein, Jack Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Intervention KW - Reviews KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41842460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Introduction+to+and+overview+of+SAMHSA+and+CSAT%27s+Screening%2C+Brief+Intervention+and+Referral+to+Treatment+initiative&rft.au=Stein%2C+Jack&rft.aulast=Stein&rft.aufirst=Jack&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender Differences in the Progression to AIDS and Mortality in the Houston Surveillance Project T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41838619; 5067169 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Arafat, Raouf AU - Awosika-olumo, Adebowale AU - Wolverton, Marcia AU - Gomez, James AU - Anderson, Lydwina Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA, Texas, Houston KW - Sex KW - Mortality KW - Acquired immune deficiency syndrome KW - Sex differences KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Gender+Differences+in+the+Progression+to+AIDS+and+Mortality+in+the+Houston+Surveillance+Project&rft.au=Arafat%2C+Raouf%3BAwosika-olumo%2C+Adebowale%3BWolverton%2C+Marcia%3BGomez%2C+James%3BAnderson%2C+Lydwina&rft.aulast=Arafat&rft.aufirst=Raouf&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Young adult tobacco program (YATO): Developing a model for tobacco cessation T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41837933; 5068803 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - McHugh, Meaghan AU - Hall, Margruetta AU - Holt, Mica AU - Dankwa-Mullan, Irene Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Tobacco KW - Young adults KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41837933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Young+adult+tobacco+program+%28YATO%29%3A+Developing+a+model+for+tobacco+cessation&rft.au=McHugh%2C+Meaghan%3BHall%2C+Margruetta%3BHolt%2C+Mica%3BDankwa-Mullan%2C+Irene&rft.aulast=McHugh&rft.aufirst=Meaghan&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Qualitative Approach to Inform Practice: Innovative Supports for Alzheimer's Caregivers T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41837925; 5067649 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Richardson, Clemelia AU - Paul, Janice Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Neurodegenerative diseases KW - Alzheimer's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41837925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=A+Qualitative+Approach+to+Inform+Practice%3A+Innovative+Supports+for+Alzheimer%27s+Caregivers&rft.au=Richardson%2C+Clemelia%3BPaul%2C+Janice&rft.aulast=Richardson&rft.aufirst=Clemelia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Decade of Occupational Mortality in Law Enforcement: Census of Fatal Occupational Injuries, 1992-2002 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41837275; 5070265 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Tiesman, Hope AU - Hendricks, Scott AU - Amandus, Harlan Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Census KW - Law enforcement KW - Mortality KW - Occupational safety KW - Injuries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41837275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=A+Decade+of+Occupational+Mortality+in+Law+Enforcement%3A+Census+of+Fatal+Occupational+Injuries%2C+1992-2002&rft.au=Tiesman%2C+Hope%3BHendricks%2C+Scott%3BAmandus%2C+Harlan&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Asthma Management Education among Low-Income Latinos: A Model for Intervention T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41836403; 5066100 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Aguirre, Luis AU - Fernan-Zegarra, Paola AU - Mora, Sonia AU - Newton, Nancy Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Respiratory diseases KW - Asthma KW - Socio-economic aspects KW - Intervention KW - Ethnic groups KW - Education KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41836403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Asthma+Management+Education+among+Low-Income+Latinos%3A+A+Model+for+Intervention&rft.au=Aguirre%2C+Luis%3BFernan-Zegarra%2C+Paola%3BMora%2C+Sonia%3BNewton%2C+Nancy&rft.aulast=Aguirre&rft.aufirst=Luis&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A proposed National Health Interview Survey supplement for occupational health surveillance T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41834564; 5067686 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Luckhaupt, Sara Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Occupational health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=A+proposed+National+Health+Interview+Survey+supplement+for+occupational+health+surveillance&rft.au=Luckhaupt%2C+Sara&rft.aulast=Luckhaupt&rft.aufirst=Sara&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integrating Rapid HIV Testing into Substance Abuse and Mental Health Settings Nationally: The Substance Abuse and Mental Health Services Administration Rapid HIV Testing Initiative T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41830395; 5067277 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - James, Kirk AU - House, Laura AU - Hewitt, Warren AU - Thompson, David AU - Jones, Stella AU - Carrington, Stephen AU - Clark, Westley Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Human immunodeficiency virus KW - Substance abuse KW - Mental disorders KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41830395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Integrating+Rapid+HIV+Testing+into+Substance+Abuse+and+Mental+Health+Settings+Nationally%3A+The+Substance+Abuse+and+Mental+Health+Services+Administration+Rapid+HIV+Testing+Initiative&rft.au=James%2C+Kirk%3BHouse%2C+Laura%3BHewitt%2C+Warren%3BThompson%2C+David%3BJones%2C+Stella%3BCarrington%2C+Stephen%3BClark%2C+Westley&rft.aulast=James&rft.aufirst=Kirk&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy People 2020: Shaping the next decade's disease prevention and health promotion agenda T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41829134; 5068368 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Blakey, Carter AU - Royall, Penelope AU - Horton, Mark AU - Klein, Richard Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Health promotion KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41829134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Healthy+People+2020%3A+Shaping+the+next+decade%27s+disease+prevention+and+health+promotion+agenda&rft.au=Blakey%2C+Carter%3BRoyall%2C+Penelope%3BHorton%2C+Mark%3BKlein%2C+Richard&rft.aulast=Blakey&rft.aufirst=Carter&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender health on the US-Mexico border T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41827503; 5066305 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Correa de Araujo, Rosaly Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41827503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Gender+health+on+the+US-Mexico+border&rft.au=Correa+de+Araujo%2C+Rosaly&rft.aulast=Correa+de+Araujo&rft.aufirst=Rosaly&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developing an occupational health surveillance needs assessment in NH: A stakeholder driven process T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41826997; 5067688 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Armenti, Karla Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Stakeholders KW - Occupational health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41826997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Developing+an+occupational+health+surveillance+needs+assessment+in+NH%3A+A+stakeholder+driven+process&rft.au=Armenti%2C+Karla&rft.aulast=Armenti&rft.aufirst=Karla&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reproductive Health communication between Parents and Adolescents falls short T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41826265; 5067623 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Patterson, Pamela AU - Ford, Calvin Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Adolescents KW - Communication KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41826265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Reproductive+Health+communication+between+Parents+and+Adolescents+falls+short&rft.au=Patterson%2C+Pamela%3BFord%2C+Calvin&rft.aulast=Patterson&rft.aufirst=Pamela&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy of self-reported secondhand smoke exposure in NHANES 1988-2002 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41811116; 5070264 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Arheart, Kristopher AU - Lee, David AU - Fleming, Lora AU - LeBlanc, William AU - Dietz, Noella AU - McCollister, Kathryn AU - Wilkinson, James AU - Lewis, John AU - Clark, John AU - Davila, Evelyn AU - Bandiera, Frank Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Passive smoking KW - Smoke KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41811116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Accuracy+of+self-reported+secondhand+smoke+exposure+in+NHANES+1988-2002&rft.au=Arheart%2C+Kristopher%3BLee%2C+David%3BFleming%2C+Lora%3BLeBlanc%2C+William%3BDietz%2C+Noella%3BMcCollister%2C+Kathryn%3BWilkinson%2C+James%3BLewis%2C+John%3BClark%2C+John%3BDavila%2C+Evelyn%3BBandiera%2C+Frank&rft.aulast=Arheart&rft.aufirst=Kristopher&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Promotoras to improve access to behavioral health services T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41810465; 5065872 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Stotz, Diana AU - Sewell, Erin Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41810465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Using+Promotoras+to+improve+access+to+behavioral+health+services&rft.au=Stotz%2C+Diana%3BSewell%2C+Erin&rft.aulast=Stotz&rft.aufirst=Diana&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dramatic Increases in Obesity and Overweight Prevalence among Ethnic-Immigrant and Social Class Groups in the United States, 1991-2006 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41808866; 5065759 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Singh, Gopal AU - Siahpush, Mohammad AU - Hiatt, Robert Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Obesity KW - Social class KW - Body weight KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41808866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Dramatic+Increases+in+Obesity+and+Overweight+Prevalence+among+Ethnic-Immigrant+and+Social+Class+Groups+in+the+United+States%2C+1991-2006&rft.au=Singh%2C+Gopal%3BSiahpush%2C+Mohammad%3BHiatt%2C+Robert&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Spiritual Well-Being and Social Support on Caregiver Well-Being Among Grandparent and Other Kinship Caregivers - NEW PRESENTER T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41808472; 5070696 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Richardson, Clemelia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Social interactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41808472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Impact+of+Spiritual+Well-Being+and+Social+Support+on+Caregiver+Well-Being+Among+Grandparent+and+Other+Kinship+Caregivers+-+NEW+PRESENTER&rft.au=Richardson%2C+Clemelia&rft.aulast=Richardson&rft.aufirst=Clemelia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of surveillance data to investigate false positive HIV Western Blots in pregnant women T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41805228; 5067050 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Chan, Shirley AU - Yang, Biru AU - Wolverton, Marcia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Human immunodeficiency virus KW - Pregnancy KW - Data processing KW - Western blotting KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41805228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Use+of+surveillance+data+to+investigate+false+positive+HIV+Western+Blots+in+pregnant+women&rft.au=Chan%2C+Shirley%3BYang%2C+Biru%3BWolverton%2C+Marcia&rft.aulast=Chan&rft.aufirst=Shirley&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Community-Based Prostate Cancer Screening for High-Risk Minority and Immigrant Populations: Prostate Cancer Incidence and Implications for Public Health Screenings T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41802579; 5069378 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Dankwa-Mullan, Irene AU - Joseph, Katty AU - Holt, Charlene Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Prostate cancer KW - Public health KW - Immigrants KW - Community involvement KW - Risk groups KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41802579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Community-Based+Prostate+Cancer+Screening+for+High-Risk+Minority+and+Immigrant+Populations%3A+Prostate+Cancer+Incidence+and+Implications+for+Public+Health+Screenings&rft.au=Dankwa-Mullan%2C+Irene%3BJoseph%2C+Katty%3BHolt%2C+Charlene&rft.aulast=Dankwa-Mullan&rft.aufirst=Irene&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - US Government Involvement in Health Issues in Vietnam T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41802295; 5066421 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Sweeney, Marie Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Vietnam KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41802295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=US+Government+Involvement+in+Health+Issues+in+Vietnam&rft.au=Sweeney%2C+Marie&rft.aulast=Sweeney&rft.aufirst=Marie&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender-Responsive Training: Addressing the needs of incarcerated women and girls T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41801813; 5068161 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Hoersch, Michelle Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Training KW - Prisons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41801813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Gender-Responsive+Training%3A+Addressing+the+needs+of+incarcerated+women+and+girls&rft.au=Hoersch%2C+Michelle&rft.aulast=Hoersch&rft.aufirst=Michelle&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A health impact assessment of a rural county's General Plan density options T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41801772; 5069110 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Lindsay, Ann AU - Harris, Celia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Rural areas KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41801772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=A+health+impact+assessment+of+a+rural+county%27s+General+Plan+density+options&rft.au=Lindsay%2C+Ann%3BHarris%2C+Celia&rft.aulast=Lindsay&rft.aufirst=Ann&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health Communication: Integrating information technology and health literacy principles into Healthy People 2020 T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41799746; 5065145 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Harris, Linda AU - Murray, Michelle AU - Baur, Cynthia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Information technology KW - Communication KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41799746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Health+Communication%3A+Integrating+information+technology+and+health+literacy+principles+into+Healthy+People+2020&rft.au=Harris%2C+Linda%3BMurray%2C+Michelle%3BBaur%2C+Cynthia&rft.aulast=Harris&rft.aufirst=Linda&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Town Hall Meetings: A Nationwide Underage Drinking Prevention Effort T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41797915; 5068842 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Ensley, Gwyndolyn Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Towns KW - Prevention KW - Drinking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41797915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Town+Hall+Meetings%3A+A+Nationwide+Underage+Drinking+Prevention+Effort&rft.au=Ensley%2C+Gwyndolyn&rft.aulast=Ensley&rft.aufirst=Gwyndolyn&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efforts at the U.S. Department of Health and Human Services (HHS) to prepare for and respond to increasing public health threats in a global society T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41794822; 5065247 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Chavez, Ilka Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41794822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Efforts+at+the+U.S.+Department+of+Health+and+Human+Services+%28HHS%29+to+prepare+for+and+respond+to+increasing+public+health+threats+in+a+global+society&rft.au=Chavez%2C+Ilka&rft.aulast=Chavez&rft.aufirst=Ilka&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Road to Health Initiative: A Creative Strategy to Increase Health Care Access to Underserved Latino Populations in Los Angeles County T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41793806; 5066232 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Alexander, Patricia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA, California, Los Angeles Cty. KW - Ethnic groups KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41793806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Road+to+Health+Initiative%3A+A+Creative+Strategy+to+Increase+Health+Care+Access+to+Underserved+Latino+Populations+in+Los+Angeles+County&rft.au=Alexander%2C+Patricia&rft.aulast=Alexander&rft.aufirst=Patricia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adults with disabilities: Quality and access to care T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41790853; 5067582 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Chevarley, Frances AU - Keer, David AU - Altman, Barbara AU - Moy, Ernest Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Disabilities KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41790853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Adults+with+disabilities%3A+Quality+and+access+to+care&rft.au=Chevarley%2C+Frances%3BKeer%2C+David%3BAltman%2C+Barbara%3BMoy%2C+Ernest&rft.aulast=Chevarley&rft.aufirst=Frances&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public health and the media: National newspaper coverage of minority health disparities T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41790157; 5065629 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Ghosh, Chandak Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41790157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Public+health+and+the+media%3A+National+newspaper+coverage+of+minority+health+disparities&rft.au=Ghosh%2C+Chandak&rft.aulast=Ghosh&rft.aufirst=Chandak&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Acculturation, Social Status, and Obesity-Related Risk Factors on Behavioral Problems among Children of Immigrant and US-born Parents T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41790103; 5067710 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Singh, Gopal AU - Kogan, Michael AU - Siahpush, Mohammad AU - Kenney, Mary Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Immigrants KW - Children KW - Social class KW - Social interactions KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41790103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Impact+of+Acculturation%2C+Social+Status%2C+and+Obesity-Related+Risk+Factors+on+Behavioral+Problems+among+Children+of+Immigrant+and+US-born+Parents&rft.au=Singh%2C+Gopal%3BKogan%2C+Michael%3BSiahpush%2C+Mohammad%3BKenney%2C+Mary&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Capacity building in Injury Prevention in a rural Navajo community T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41787249; 5065479 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Bill, Nancy AU - Begay, Mary Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Rural areas KW - Prevention KW - Injuries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41787249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Capacity+building+in+Injury+Prevention+in+a+rural+Navajo+community&rft.au=Bill%2C+Nancy%3BBegay%2C+Mary&rft.aulast=Bill&rft.aufirst=Nancy&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increase health promotion & disease prevention to underserved latino populations in T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41786361; 5066175 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Alexander, Patricia Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Health promotion KW - Prevention KW - Ethnic groups KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41786361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Increase+health+promotion+%26amp%3B+disease+prevention+to+underserved+latino+populations+in&rft.au=Alexander%2C+Patricia&rft.aulast=Alexander&rft.aufirst=Patricia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Non-inferiority Trial Design Issues in Treatment-Experienced (TE) Patients with Active Optimized Background Regimens (OBR) T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40328149; 5260765 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Soon, G AU - Zhou, S AU - Qi, K. AU - Hammerstrom, T AU - Smith, F AU - Rhee, S AU - Naeger, L AU - Chan-Tack, K AU - Struble, K AU - Murray, J Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40328149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Non-inferiority+Trial+Design+Issues+in+Treatment-Experienced+%28TE%29+Patients+with+Active+Optimized+Background+Regimens+%28OBR%29&rft.au=Soon%2C+G%3BZhou%2C+S%3BQi%2C+K.%3BHammerstrom%2C+T%3BSmith%2C+F%3BRhee%2C+S%3BNaeger%2C+L%3BChan-Tack%2C+K%3BStruble%2C+K%3BMurray%2C+J&rft.aulast=Soon&rft.aufirst=G&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluating the Role of Anthrax Toxin in the Pathogenesis of B. anthracis T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40327833; 5260802 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Merkel, Tod Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Anthrax KW - Toxins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40327833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Evaluating+the+Role+of+Anthrax+Toxin+in+the+Pathogenesis+of+B.+anthracis&rft.au=Merkel%2C+Tod&rft.aulast=Merkel&rft.aufirst=Tod&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Moraxella catarrhalis Bacteremia in Children T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40321065; 5259234 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Crewalk, J AU - Pikis, A AU - Campos, J AU - Nambiar, S AU - Kadoorie, C AU - Jantausch, B Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Children KW - Bacteremia KW - Moraxella catarrhalis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40321065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Moraxella+catarrhalis+Bacteremia+in+Children&rft.au=Crewalk%2C+J%3BPikis%2C+A%3BCampos%2C+J%3BNambiar%2C+S%3BKadoorie%2C+C%3BJantausch%2C+B&rft.aulast=Crewalk&rft.aufirst=J&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post-Marketing (PM) Analysis of Vancomycin Associated Drug Rash, Eosinophilia, and Systemic Symptoms (DRESS) Syndrome T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40315986; 5259650 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Blank, J AU - Levorson, R AU - Nambiar, S Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Drugs KW - Eosinophilia KW - Exanthema KW - Side effects KW - Vancomycin KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40315986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Post-Marketing+%28PM%29+Analysis+of+Vancomycin+Associated+Drug+Rash%2C+Eosinophilia%2C+and+Systemic+Symptoms+%28DRESS%29+Syndrome&rft.au=Blank%2C+J%3BLevorson%2C+R%3BNambiar%2C+S&rft.aulast=Blank&rft.aufirst=J&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ongoing Concerns, New Laws, New Approaches- the FDA Perspective On Assessing Safety and Benefit of Rheumatology Treatments T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41899174; 5122023 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Seligman, Paul Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Ongoing+Concerns%2C+New+Laws%2C+New+Approaches-+the+FDA+Perspective+On+Assessing+Safety+and+Benefit+of+Rheumatology+Treatments&rft.au=Seligman%2C+Paul&rft.aulast=Seligman&rft.aufirst=Paul&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Why Oregon Went Wrong AN - 57261303; 200900014 AB - Oregon's brave plan to explicitly ration health care in order to cover more people soon ran into problems. Vidhya Alakeson looks at the reasons and asks whether history will repeat itself. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Alakeson, Vidhya AD - Department of Health and Human Services, Washington DC, USA alakesonvidhya@yahoo.co.uk Y1 - 2008/10/18/ PY - 2008 DA - 2008 Oct 18 SP - 900 EP - 901 PB - British Medical Association, BMJ Publishing Group, London UK VL - 337 IS - 7675 SN - 0959-535X, 0959-535X KW - Economics KW - Rationing KW - Health policy KW - Health services KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57261303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Why+Oregon+Went+Wrong&rft.au=Alakeson%2C+Vidhya&rft.aulast=Alakeson&rft.aufirst=Vidhya&rft.date=2008-10-18&rft.volume=337&rft.issue=7675&rft.spage=900&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-01-08 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Health services; Rationing; Health policy; Economics ER - TY - JOUR T1 - Possession, use, and transfer of select agents and toxins. Final rule. AN - 69819208; 19024787 AB - This document completes the biennial review and republication of the lists of biological agents and toxins regulated by the U.S. Department of Health and Human Services (HHS), as well as those biological agents and toxins regulated by both HHS and the U.S. Department of Agriculture (USDA). Because USDA has chosen to no longer regulate ten biological agents and toxins which HHS still believes have the potential to pose a severe threat to public health and safety, we have moved those ten biological agents and toxins from the overlap select agents and toxins section to the HHS select agents and toxins section of the select agent regulations. In a companion document published in this issue of the Federal Register, the USDA has established corresponding final rules regarding the select agents and toxins regulated only by the USDA, as well as those overlap select agents and toxins regulated by both agencies. JF - Federal register AU - Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS) AD - Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS) Y1 - 2008/10/16/ PY - 2008 DA - 2008 Oct 16 SP - 61363 EP - 61366 VL - 73 IS - 201 SN - 0097-6326, 0097-6326 KW - Biological Products KW - 0 KW - Neurotoxins KW - Toxins, Biological KW - Health technology assessment KW - United States KW - Bioterrorism -- legislation & jurisprudence KW - Humans KW - Bioterrorism -- prevention & control KW - United States Department of Agriculture -- legislation & jurisprudence KW - Government Regulation KW - United States Dept. of Health and Human Services -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69819208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Possession%2C+use%2C+and+transfer+of+select+agents+and+toxins.+Final+rule.&rft.au=Centers+for+Disease+Control+and+Prevention+%28CDC%29%2C+Department+of+Health+and+Human+Services+%28HHS%29&rft.aulast=Centers+for+Disease+Control+and+Prevention+%28CDC%29&rft.aufirst=Department+of+Health+and+Human+Services&rft.date=2008-10-16&rft.volume=73&rft.issue=201&rft.spage=61363&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-02 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli. AN - 69685556; 18771711 AB - In the present study, we characterized differential expressions of phosphorylated Ca(2+)/calmodulin-dependent protein kinase IIalpha (pCaMKIIalpha) and phosphorylated extracellular signal-regulated protein (pERK) in the mouse hippocampus induced by various nociceptive stimuli. In an immunoblot study, s.c. injection of formalin and intrathecal (i.t.) injections of glutamate, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1 beta) significantly increased pCaMKIIalpha expression in the hippocampus, but i.p. injections of acetic acid did not. pERK1/2 expression was also increased by i.t. injection of glutamate, TNF-alpha, and IL-1beta but not by s.c. injections of formalin or i.p. injections of acetic acid. In an immunohistochemical study, we found that increased pCaMKIIalpha and pERK expressions were mainly located at CA3 or the dentate gyrus of the hippocampus. In a behavioral study, we assessed the effects of PD98059 (a MEK 1/2 inhibitor) and KN-93 (a CaMKII inhibitor) following i.c.v. administration on the nociceptive behaviors induced by i.t. injections of glutamate, pro-inflammatory cytokines (TNF-alpha or IL-1beta), and i.p. injections of acetic acid. PD98059 as well as KN-93 significantly attenuated the nociceptive behavior induced by glutamate, pro-inflammatory cytokines, and acetic acid. Our results suggest that (1) pERKalpha and pCaMK-II located in the hippocampus are important regulators during the nociceptive processes induced by s.c. formalin, i.t. glutamate, i.t. pro-inflammatory cytokines, and i.p. acetic acid injection, respectively, and (2) the alteration of pERK and pCaMKIIalpha in nociceptive processing induced by formalin, glutamate, pro-inflammatory cytokines and acetic acid was modulated in a different manner. JF - Neuroscience AU - Seo, Y-J AU - Kwon, M-S AU - Choi, H-W AU - Choi, S-M AU - Kim, Y-W AU - Lee, J-K AU - Park, S-H AU - Jung, J-S AU - Suh, H-W AD - Division of Recombinant Product, Biopharmaceutical Bureau, Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul, 122-704, Republic of Korea. Y1 - 2008/10/15/ PY - 2008 DA - 2008 Oct 15 SP - 436 EP - 449 VL - 156 IS - 3 SN - 0306-4522, 0306-4522 KW - 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one KW - 0 KW - Benzylamines KW - Flavonoids KW - Interleukin-1beta KW - Protein Kinase Inhibitors KW - Sulfonamides KW - Tumor Necrosis Factor-alpha KW - KN 93 KW - 139298-40-1 KW - Formaldehyde KW - 1HG84L3525 KW - Glutamic Acid KW - 3KX376GY7L KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2 KW - EC 2.7.11.17 KW - Camk2a protein, mouse KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Acetic Acid KW - Q40Q9N063P KW - Index Medicus KW - Benzylamines -- pharmacology KW - Animals KW - Mice, Inbred ICR KW - Analysis of Variance KW - Protein Kinase Inhibitors -- pharmacology KW - Pain Measurement -- methods KW - Mice KW - Behavior, Animal KW - Phosphorylation KW - Sulfonamides -- pharmacology KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Flavonoids -- pharmacology KW - Time Factors KW - Male KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2 -- metabolism KW - Pain -- chemically induced KW - Hippocampus -- enzymology KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Pain -- metabolism KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69685556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Differential+expression+of+phosphorylated+Ca2%2B%2Fcalmodulin-dependent+protein+kinase+II+and+phosphorylated+extracellular+signal-regulated+protein+in+the+mouse+hippocampus+induced+by+various+nociceptive+stimuli.&rft.au=Seo%2C+Y-J%3BKwon%2C+M-S%3BChoi%2C+H-W%3BChoi%2C+S-M%3BKim%2C+Y-W%3BLee%2C+J-K%3BPark%2C+S-H%3BJung%2C+J-S%3BSuh%2C+H-W&rft.aulast=Seo&rft.aufirst=Y-J&rft.date=2008-10-15&rft.volume=156&rft.issue=3&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2008.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-14 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2008.08.002 ER - TY - CPAPER T1 - Immunotherapy with CpG Oligonucleotides and Antibodies to TNF? Rescue Neonatal Mice from Lethal Arena Virus-induced Meningoencephalitis. T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42061620; 4976147 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Pedras-Vasconcelos, Joao A AU - Puig, Montserrat AU - Sauder, Christian AU - Wolbert, Candie AU - Ovanesov, Mikhail AU - Verthelyi, Daniela Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Immunotherapy KW - Mice KW - Neonates KW - Tumor necrosis factor KW - Antibodies KW - Oligonucleotides KW - Meningoencephalitis KW - CpG islands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42061620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Immunotherapy+with+CpG+Oligonucleotides+and+Antibodies+to+TNF%3F+Rescue+Neonatal+Mice+from+Lethal+Arena+Virus-induced+Meningoencephalitis.&rft.au=Pedras-Vasconcelos%2C+Joao+A%3BPuig%2C+Montserrat%3BSauder%2C+Christian%3BWolbert%2C+Candie%3BOvanesov%2C+Mikhail%3BVerthelyi%2C+Daniela&rft.aulast=Pedras-Vasconcelos&rft.aufirst=Joao&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coalbed Discontinuity Effects on the Production of Degasification Boreholes and on Emissions During Longwall Mining T2 - 2008 Society of Petroleum Engineers Eastern Regional and AAPG Eastern Section Joint Meeting AN - 41103759; 4951983 JF - 2008 Society of Petroleum Engineers Eastern Regional and AAPG Eastern Section Joint Meeting AU - Karacan, C O AU - Goodman, G Y1 - 2008/10/11/ PY - 2008 DA - 2008 Oct 11 KW - Boreholes KW - Mining KW - Emissions KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41103759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Society+of+Petroleum+Engineers+Eastern+Regional+and+AAPG+Eastern+Section+Joint+Meeting&rft.atitle=Coalbed+Discontinuity+Effects+on+the+Production+of+Degasification+Boreholes+and+on+Emissions+During+Longwall+Mining&rft.au=Karacan%2C+C+O%3BGoodman%2C+G&rft.aulast=Karacan&rft.aufirst=C&rft.date=2008-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Society+of+Petroleum+Engineers+Eastern+Regional+and+AAPG+Eastern+Section+Joint+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.aapgspe2008.org/p12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats. AN - 69497311; 18682277 AB - Neurochemical studies suggest that baclofen, an agonist at GABA(B) receptors, may be useful for treatment of nicotine dependence. However, its ability to selectively reduce nicotine's abuse-related behavioral effects remains in question. We assessed effects of baclofen doses ranging from 0.1 to 3mg/kg on nicotine-induced conditioned place preferences (CPPs), nicotine discrimination, locomotor activity and food-reinforced behavior in male Sprague-Dawley rats. The high dose of baclofen (3mg/kg) totally eliminated food-reinforced responding and significantly decreased locomotor activity. Lower doses of baclofen did not have nicotine-like discriminative effects in rats trained to discriminate 0.4mg/kg nicotine from saline under a fixed-ratio 10 schedule of food delivery. Lower doses of baclofen also did not reduce discriminative stimulus effects of the training dose of nicotine and did not significantly shift the dose-response curve for nicotine discrimination. Rats treated with the high 3mg/kg dose of baclofen did not express nicotine-induced CPP. These experiments, along with previous reports that baclofen can reduce intravenous nicotine self-administration behavior, confirm the potential utility of baclofen as a tool for smoking cessation. JF - Neuroscience letters AU - Le Foll, Bernard AU - Wertheim, Carrie E AU - Goldberg, Steven R AD - National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA. bernard_lefoll@camh.net Y1 - 2008/10/10/ PY - 2008 DA - 2008 Oct 10 SP - 236 EP - 240 VL - 443 IS - 3 SN - 0304-3940, 0304-3940 KW - GABA Agonists KW - 0 KW - Nicotinic Agonists KW - Nicotine KW - 6M3C89ZY6R KW - Baclofen KW - H789N3FKE8 KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Reinforcement Schedule KW - Dose-Response Relationship, Drug KW - Motor Activity -- drug effects KW - Male KW - Conditioning, Operant -- drug effects KW - Discrimination (Psychology) -- drug effects KW - GABA Agonists -- pharmacology KW - Reward KW - Discrimination (Psychology) -- physiology KW - Conditioning, Operant -- physiology KW - Nicotine -- pharmacology KW - Nicotinic Agonists -- pharmacology KW - Baclofen -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69497311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Effects+of+baclofen+on+conditioned+rewarding+and+discriminative+stimulus+effects+of+nicotine+in+rats.&rft.au=Le+Foll%2C+Bernard%3BWertheim%2C+Carrie+E%3BGoldberg%2C+Steven+R&rft.aulast=Le+Foll&rft.aufirst=Bernard&rft.date=2008-10-10&rft.volume=443&rft.issue=3&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/10.1016%2Fj.neulet.2008.07.074 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-03 N1 - Date created - 2008-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 2003 Jun;167(4):335-43 [12684733] Neuroscience. 2003;118(1):123-34 [12676144] Psychopharmacology (Berl). 2004 Mar;172(2):179-86 [14610636] Neuroreport. 2004 Sep 15;15(13):2139-43 [15486497] J Neurochem. 1977 Nov;29(5):797-802 [591956] J Consult Clin Psychol. 1982 Feb;50(1):71-86 [7056922] Psychopharmacology (Berl). 1983;81(1):54-60 [6415731] Psychopharmacology (Berl). 1984;84(3):413-9 [6440189] Pharmacol Biochem Behav. 1985 Feb;22(2):237-41 [2858867] Br J Pharmacol. 1987 Jan;90(1):239-46 [2880625] Eur J Pharmacol. 1986 Dec 16;132(2-3):337-8 [3816984] Trends Pharmacol Sci. 1992 May;13(5):177-84 [1604710] Pharmacol Biochem Behav. 1994 Jul;48(3):817-20 [7938142] Nature. 1996 Jul 18;382(6588):255-7 [8717040] Neuropsychopharmacology. 1996 Oct;15(4):417-23 [8887996] BMJ. 1997 Jan 18;314(7075):180-1 [9022432] Psychopharmacology (Berl). 1997 Feb;129(4):390-7 [9085409] Psychopharmacology (Berl). 1997 Jun;131(3):271-7 [9203238] Nature. 1997 Nov 27;390(6658):401-4 [9389479] Behav Pharmacol. 1998 May;9(3):195-206 [9832934] Synapse. 1999 Jan;31(1):76-86 [10025686] J Pharmacol Exp Ther. 1999 Mar;288(3):1053-73 [10027843] Psychopharmacology (Berl). 1999 Apr;143(2):209-14 [10326784] J Pharmacol Exp Ther. 1999 Sep;290(3):1369-74 [10454516] Ann N Y Acad Sci. 2004 Oct;1025:491-503 [15542754] Neuropsychopharmacology. 2005 Jan;30(1):119-28 [15266350] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Psychopharmacology (Berl). 2005 Apr;178(4):481-92 [15765262] Neuropsychopharmacology. 2005 Apr;30(4):720-30 [15562293] Psychopharmacology (Berl). 2006 Mar;184(3-4):367-81 [16205918] Lancet. 2007 Dec 8;370(9603):1915-22 [18068515] Addict Biol. 2008 Jun;13(2):239-52 [18482433] Life Sci. 2000 Feb 18;66(13):PL169-73 [10737423] Psychopharmacology (Berl). 2000 Feb;148(3):314-21 [10755745] Nicotine Tob Res. 2001 May;3(2):123-9 [11403726] Pharmacol Biochem Behav. 2001 Dec;70(4):515-30 [11796151] Drug Alcohol Depend. 2002 Feb 1;65(3):209-20 [11841892] Synapse. 2002 May;44(2):61-3 [11891877] Neuropharmacology. 2002 Mar;42(4):530-9 [11955523] Life Sci. 2001 Dec 7;70(3):349-56 [12005267] Synapse. 2002 Jun 15;44(4):252-3 [11984860] Alcohol Alcohol. 2002 Sep-Oct;37(5):478-84 [12217943] Alcohol Alcohol. 2002 Sep-Oct;37(5):495-8 [12217945] Behav Pharmacol. 2002 Sep;13(5-6):451-63 [12394421] Mol Psychiatry. 2003 Feb;8(2):225-30 [12610655] Neuropsychopharmacology. 2003 Mar;28(3):510-8 [12629530] Synapse. 2003 Oct;50(1):1-6 [12872287] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neulet.2008.07.074 ER - TY - CPAPER T1 - New aspects of COPD ethiopathogenesis T2 - 2008 Annual Congress of the European Respiratory Society AN - 41121931; 4962935 JF - 2008 Annual Congress of the European Respiratory Society AU - Kobylyansky, Viacheslav AU - Ivanov, Igor AU - Gamal, Evgeniy AU - Babadzhanova, Gulnara AU - Petrova, Tatyana Y1 - 2008/10/04/ PY - 2008 DA - 2008 Oct 04 KW - Chronic obstructive pulmonary disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41121931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Congress+of+the+European+Respiratory+Society&rft.atitle=New+aspects+of+COPD+ethiopathogenesis&rft.au=Kobylyansky%2C+Viacheslav%3BIvanov%2C+Igor%3BGamal%2C+Evgeniy%3BBabadzhanova%2C+Gulnara%3BPetrova%2C+Tatyana&rft.aulast=Kobylyansky&rft.aufirst=Viacheslav&rft.date=2008-10-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Congress+of+the+European+Respiratory+Society&rft.issn=&rft_id=info:doi/ L2 - http://dev.ersnet.org/413-scientific-programme.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Renal Papillary Antigen-1 (RPA-1) Cross-Reactivity in Necrotic Renal Proximal Tubules: Significance of Immunohistochemistry and Histopathology AN - 877589009; 13617802 JF - Toxicologic Pathology AU - Zhang, Jun AU - Shaw, Martin AU - Goering, Peter L AD - Center for Drug Evaluation and Research, FDA Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 891 EP - 893 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 36 IS - 6 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877589009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Renal+Papillary+Antigen-1+%28RPA-1%29+Cross-Reactivity+in+Necrotic+Renal+Proximal+Tubules%3A+Significance+of+Immunohistochemistry+and+Histopathology&rft.au=Zhang%2C+Jun%3BShaw%2C+Martin%3BGoering%2C+Peter+L&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2008-10-01&rft.volume=36&rft.issue=6&rft.spage=891&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623308324960 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 4 N1 - Last updated - 2012-06-18 DO - http://dx.doi.org/10.1177/0192623308324960 ER - TY - JOUR T1 - Comparison of Web-Based versus Paper-and-Pencil Self-Administered Questionnaire: Effects on Health Indicators in Dutch Adolescents AN - 839582133; 201104335 AB - Objective. The aim of this study is to investigate differences in responses related to (mental) health and behavior between two methods of data collection: web-based (web) and paper-and-pencil (p&p). Study Design. Within each participating school all third-grade classes (mainly 14-15-year-old pupils) were randomly assigned to either the Internet condition (n=271) or the paper-and-pencil condition (n=261). Principal Findings. Significant but small differences were found for the strengths and difficulties subscales "emotional symptoms" (p&p>web) and "prosocial behavior" (p&p>web), and carrying a weapon (web>p&p). Perceived level of privacy and confidentiality did not differ between the two modes. Conclusions. The findings suggest that in a controlled school setting, web-based administration of health indicators yields almost the same results as paper-and-pencil administration. To generalize these findings, we recommend repeated studies in other populations and settings. Adapted from the source document. JF - Health Services Research AU - van de Looij-Jansen, Petra M. AU - de Wilde, Erik Jan AD - Youth Department, Municipal Public Health Service for the Rotterdam Area, PO Box 70032, 3000 LP Rotterdam, The Netherlands Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1708 EP - 1721 PB - Blackwell Publishers, Oxford UK VL - 43 IS - 5p1 SN - 0017-9124, 0017-9124 KW - Methodology computerized questionnaire preventive youth health care adolescents SDQ KW - Symptoms KW - Prosocial behaviour KW - Health indicators KW - Confidentiality KW - Computer based KW - Internet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839582133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Comparison+of+Web-Based+versus+Paper-and-Pencil+Self-Administered+Questionnaire%3A+Effects+on+Health+Indicators+in+Dutch+Adolescents&rft.au=van+de+Looij-Jansen%2C+Petra+M.%3Bde+Wilde%2C+Erik+Jan&rft.aulast=van+de+Looij-Jansen&rft.aufirst=Petra&rft.date=2008-10-01&rft.volume=43&rft.issue=5p1&rft.spage=1708&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2008.00860.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Internet; Computer based; Health indicators; Prosocial behaviour; Confidentiality; Symptoms DO - http://dx.doi.org/10.1111/j.1475-6773.2008.00860.x ER - TY - JOUR T1 - Hospital Quality, Efficiency, and Input Slack Differentials AN - 839581733; 201104324 AB - Objective. To use an advance in data envelopment analysis (DEA) called congestion analysis to assess the trade-offs between quality and efficiency in U.S. hospitals. Study Setting. Urban U.S. hospitals in 34 states operating in 2004. Study Design and Data Collection. Input and output data from 1,377 urban hospitals were taken from the American Hospital Association Annual Survey and the Medicare Cost Reports. Nurse-sensitive measures of quality came from the application of the Patient Safety Indicator (PSI) module of the Agency for Healthcare Research and Quality (AHRQ) Quality Indicator software to State Inpatient Databases (SID) provided by the Healthcare Cost and Utilization Project (HCUP). Data Analysis. In the first step of the study, hospitals' relative output-based efficiency was determined in order to obtain a measure of congestion (i.e., the productivity loss due to the occurrence of patient safety events). The outputs were adjusted to account for this productivity loss, and a second DEA was performed to obtain input slack values. Differences in slack values between unadjusted and adjusted outputs were used to measure either relative inefficiency or a need for quality improvement. Principal Findings. Overall, the hospitals in our sample could increase the total amount of outputs produced by an average of 26 percent by eliminating inefficiency. About 3 percent of this inefficiency can be attributed to congestion. Analysis of subsamples showed that teaching hospitals experienced no congestion loss. We found that quality of care could be improved by increasing the number of labor inputs in low-quality hospitals, whereas high-quality hospitals tended to have slack on personnel. Conclusions. Results suggest that reallocation of resources could increase the relative quality among hospitals in our sample. Further, higher quality in some dimensions of care need not be achieved as a result of higher costs or through reduced access to health care. Adapted from the source document. JF - Health Services Research AU - Valdmanis, Vivian G AU - Rosko, Michael D AU - Mutter, Ryan L AD - Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, 540 Gaither Road, Rockville, MD 20850 Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1830 EP - 1848 PB - Blackwell Publishers, Oxford UK VL - 43 IS - 5p2 SN - 0017-9124, 0017-9124 KW - Hospital efficiency data envelopment analysis congestion patient safety nurse-sensitive outcomes KW - Quality of care KW - Health care KW - Productivity KW - Patient care KW - Congestion KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839581733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Hospital+Quality%2C+Efficiency%2C+and+Input+Slack+Differentials&rft.au=Valdmanis%2C+Vivian+G%3BRosko%2C+Michael+D%3BMutter%2C+Ryan+L&rft.aulast=Valdmanis&rft.aufirst=Vivian&rft.date=2008-10-01&rft.volume=43&rft.issue=5p2&rft.spage=1830&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2008.00893.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Hospitals; Quality of care; Congestion; Patient care; Health care; Productivity DO - http://dx.doi.org/10.1111/j.1475-6773.2008.00893.x ER - TY - JOUR T1 - Ozone and Other Air Pollutants and the Risk of Oral Clefts AN - 743580412; 201004-31-0304787 (CE); 12103981 (EN) AB - BACKGROUND: Air pollution influences the development of oral clefts in animals. There are few epidemiologic data on the relation of prenatal air pollution exposure and the risk of oral clefts. OBJECTIVES: Our goal in this study was to assess the relations between exposure to ambient air pollution and the risk of cleft lip with or without cleft palate (CL/P). METHODS: We conducted a population-based case-control study of all 653 cases of CL/P and a random sample of 6,530 control subjects from 721,289 Taiwanese newborns in 2001-2003. We used geographic information systems to form exposure parameters for sulfur dioxide, nitrogen oxides, ozone, carbon monoxide, and particulate matter with an aerodynamic diameter or= 10 microm (PM10) during the first 3 months of pregnancy using inverse distance weighting method. We present the effect estimates as odds ratios (ORs) per 10-ppb change for SO2, NO(x), and O3, 100-ppb change for CO, and 10-microg/m3 change for PM10. RESULTS: The risk of CL/P was increased in relation to O3 levels in the first gestational month [adjusted OR = 1.20; 95% confidence interval (CI), 1.02-1.39] and second gestational month (adjusted OR = 1.25; 95% CI, 1.03-1.52) in the range from 16.7 ppb to 45.1 ppb, but was not related to CO, NO(x), SO2, or PM10. CONCLUSIONS: The study provides new evidence that exposure to outdoor air O3 during the first and second month of pregnancy may increase the risk of CL/P. Similar levels of O3 are encountered globally by large numbers of pregnant women. JF - Environmental Health Perspectives AU - Hwang, Bing-Fang AU - Jaakkola, Jouni J K PY - 2008 SP - 1411 EP - 1415 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Air pollution KW - Carbon monoxide KW - Pregnancy KW - Health KW - Ozone KW - Adjustment KW - Geographic information systems KW - Epidemiology KW - Estimates KW - Nitrogen oxides KW - Confidence intervals KW - Sulfur dioxide KW - Satellite navigation systems KW - Weighting methods KW - Copyrights KW - Inverse KW - Animals KW - Pollutants KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743580412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Ozone+and+Other+Air+Pollutants+and+the+Risk+of+Oral+Clefts&rft.au=Hwang%2C+Bing-Fang%3BJaakkola%2C+Jouni+J+K&rft.aulast=Hwang&rft.aufirst=Bing-Fang&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Exposure of Neonatal Rats to Parathion Elicits Sex-Selective Impairment of Acetylcholine Systems in Brain Regions during Adolescence and Adulthood AN - 743577496; 201004-31-0304803 (CE); 12103997 (EN) AB - BACKGROUND: Organophosphates elicit developmental neurotoxicity through multiple mechanisms other than their shared property as cholinesterase inhibitors. Accordingly, these agents may differ in their effects on specific brain circuits. OBJECTIVES: We gave parathion to neonatal rats [postnatal days (PNDs) 1-4], at daily doses of 0.1 or 0.2 mg/kg, spanning the threshold for barely detectable cholinesterase inhibition and systemic effects. METHODS: We assessed neurochemical indices related to the function of acetylcholine (ACh) synapses (choline acetyltransferase, presynaptic high-affinity choline transporter, nicotinic cholinergic receptors) in brain regions comprising all the major ACh projections, with determinations carried out from adolescence to adulthood (PNDs 30, 60, and 100). RESULTS: Parathion exposure elicited lasting alterations in ACh markers in the frontal/parietal cortex, temporal/occipital cortex, midbrain, hippocampus, and striatum. In cerebrocortical areas, midbrain, and hippocampus, effects in males were generally greater than in females, whereas in the striatum, females were targeted preferentially. Superimposed on this general pattern, the cerebrocortical effects showed a nonmonotonic dose-response relationship, with regression of the defects at the higher parathion dose; this relationship has been seen also after comparable treatments with chlorpyrifos and diazinon and likely represents the involvement of cholinesterase-related actions that mask or offset the effects of lower doses. CONCLUSIONS: Neonatal exposure to parathion, at doses straddling the threshold for cholinesterase inhibition, compromises indices of ACh synaptic function in adolescence and adulthood. Differences between the effects of parathion compared with chlorpyrifos or diazinon and the non-monotonic dose-effect relationships reinforce the conclusion that various organophosphates diverge in their effects on neurodevelopment, unrelated to their anticholinesterase actions. JF - Environmental Health Perspectives AU - Slotkin, Theodore A AU - Bodwell, Bethany E AU - Ryde, Ian T AU - Levin, Edward D AU - Seidler, Frederic J PY - 2008 SP - 1308 EP - 1314 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Inhibitors KW - Brain KW - Cholinesterase KW - Chlorpyrifos KW - Choline KW - Health KW - Thresholds KW - Inhibition KW - Organophosphates KW - Females KW - Hippocampus KW - Cortexes KW - Rats KW - Transporter KW - Regression KW - Impairment KW - Cholinergics KW - Synapses KW - Markers KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743577496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+of+Neonatal+Rats+to+Parathion+Elicits+Sex-Selective+Impairment+of+Acetylcholine+Systems+in+Brain+Regions+during+Adolescence+and+Adulthood&rft.au=Slotkin%2C+Theodore+A%3BBodwell%2C+Bethany+E%3BRyde%2C+Ian+T%3BLevin%2C+Edward+D%3BSeidler%2C+Frederic+J&rft.aulast=Slotkin&rft.aufirst=Theodore&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1308&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Traffic-Related Air Pollution and Asthma Onset in Children: A Prospective Cohort Study with Individual Exposure Measurement AN - 743541817; 201004-31-0304794 (CE); 12103988 (EN) AB - BACKGROUND: The question of whether air pollution contributes to asthma onset remains unresolved. OBJECTIVES: In this study, we assessed the association between asthma onset in children and traffic-related air pollution. METHODS: We selected a sample of 217 children from participants in the Southern California Children's Health Study, a prospective cohort designed to investigate associations between air pollution and respiratory health in children 10-18 years of age. Individual covariates and new asthma incidence (30 cases) were reported annually through questionnaires during 8 years of follow-up. Children had nitrogen dioxide monitors placed outside their home for 2 weeks in the summer and 2 weeks in the fall-winter season as a marker of traffic-related air pollution. We used multilevel Cox models to test the associations between asthma and air pollution. RESULTS: In models controlling for confounders, incident asthma was positively associated with traffic pollution, with a hazard ratio (HR) of 1.29 [95% confidence interval (CI), 1.07-1.56] across the average within-community interquartile range of 6.2 ppb in annual residential NO2. Using the total interquartile range for all measurements of 28.9 ppb increased the HR to 3.25 (95% CI, 1.35-7.85). CONCLUSIONS: In this cohort, markers of traffic-related air pollution were associated with the onset of asthma. The risks observed suggest that air pollution exposure contributes to new-onset asthma. JF - Environmental Health Perspectives AU - Jerrett, Michael AU - Shankardass, Ketan AU - Berhane, Kiros AU - Gauderman, W James AU - Kuenzli, Nino AU - Avol, Edward AU - Gilliland, Frank AU - Lurmann, Fred AU - Molitor, Jassy N AU - Molitor, John T AU - Thomas, Duncan C AU - Peters, John AU - McConnell, Rob PY - 2008 SP - 1433 EP - 1438 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Air pollution KW - Asthma KW - Children KW - Health KW - Nitrogen dioxide KW - Markers KW - Monitors KW - Risk KW - Traffic flow KW - Southern California KW - Traffic engineering KW - Seasons KW - Mathematical models KW - Confidence intervals KW - Hazards KW - Multilevel KW - Incidence KW - Copyrights KW - Summer KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743541817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Traffic-Related+Air+Pollution+and+Asthma+Onset+in+Children%3A+A+Prospective+Cohort+Study+with+Individual+Exposure+Measurement&rft.au=Jerrett%2C+Michael%3BShankardass%2C+Ketan%3BBerhane%2C+Kiros%3BGauderman%2C+W+James%3BKuenzli%2C+Nino%3BAvol%2C+Edward%3BGilliland%2C+Frank%3BLurmann%2C+Fred%3BMolitor%2C+Jassy+N%3BMolitor%2C+John+T%3BThomas%2C+Duncan+C%3BPeters%2C+John%3BMcConnell%2C+Rob&rft.aulast=Jerrett&rft.aufirst=Michael&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1433&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Relationship between Prenatal PCB Exposure and Intelligence (IQ) in 9-Year-Old Children AN - 743515030; 201004-31-0304786 (CE); 12103980 (EN) AB - BACKGROUND: Several epidemiologic studies have demonstrated relationships between prenatal exposure to polychlorinated biphenyls (PCBs) and modest cognitive impairments in infancy and early childhood. However, few studies have followed cohorts of exposed children long enough to examine the possible impact of prenatal PCB exposure on psychometric intelligence in later childhood. Of the few studies that have done so, one in the Great Lakes region of the United States reported impaired IQ in children prenatally exposed to PCBs, whereas another found no association. OBJECTIVES: This study was designed to determine whether environmental exposure to PCBs predicts lower IQ in school-age children in the Great Lakes region of the northeastern United States. METHODS: We measured prenatal exposure to PCBs and IQ at 9 years of age in 156 subjects from Oswego, New York. We also measured 50 potential predictors of intelligence in children, including repeated measures of the home environment [Home Observation for Measurement of the Environment (HOME)], socioeconomic status (SES), parental IQ, alcohol/cigarette use, neonatal risk factors, and nutrition. RESULTS: For each 1-ng/g (wet weight) increase in PCBs in placental tissue, Full Scale IQ dropped by three points (p = 0.02), and Verbal IQ dropped by four points (p = 0.003). The median PCB level was 1.50 ng/g, with a lower quartile of 1.00 ng/g and an upper quartile of 2.06 ng/g. Moreover, this association was significant after controlling for many potential confounders, including prenatal exposure to methylmercury, dichlorodiphenyldichloroethylene, hexachlorobenzene, and lead. CONCLUSIONS: These results, in combination with similar results obtained from a similar study in the Great Lakes conducted 10 years earlier, indicate that prenatal PCB exposure in the Great Lakes region is associated with lower IQ in children. JF - Environmental Health Perspectives AU - Stewart, Paul W AU - Lonky, Edward AU - Reihman, Jacqueline AU - Pagano, James AU - Gump, Brooks B AU - Darvill, Thomas PY - 2008 SP - 1416 EP - 1422 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Circuit boards KW - Lakes KW - Printed circuits KW - Intelligence KW - Health KW - Ecological risk assessment KW - Quartiles KW - Exposure KW - Nutrition KW - Risk KW - Psychometrics KW - Impairment KW - Epidemiology KW - Alcohols KW - Cigarettes KW - Copyrights KW - Polychlorinated biphenyls KW - Hexachlorobenzene KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743515030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Relationship+between+Prenatal+PCB+Exposure+and+Intelligence+%28IQ%29+in+9-Year-Old+Children&rft.au=Stewart%2C+Paul+W%3BLonky%2C+Edward%3BReihman%2C+Jacqueline%3BPagano%2C+James%3BGump%2C+Brooks+B%3BDarvill%2C+Thomas&rft.aulast=Stewart&rft.aufirst=Paul&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1416&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Effect of Heat Waves on Mental Health in a Temperate Australian City AN - 743511911; 201004-31-0304796 (CE); 12103990 (EN) AB - OBJECTIVE: The goal of this study was to identify mental, behavioral, and cognitive disorders that may be triggered or exacerbated during heat waves, predisposing individuals to heat-related morbidity and mortality. DESIGN: Using health outcome data from Adelaide, South Australia, for 1993-2006, we estimated the effect of heat waves on hospital admissions and mortalities attributed to mental, behavioral, and cognitive disorders. We analyzed data using Poisson regression accounting for overdispersion and controlling for season and long-term trend, and we performed threshold analysis using hockey stick regression. RESULTS: Above a threshold of 26.7 degrees C, we observed a positive association between ambient temperature and hospital admissions for mental and behavioral disorders. Compared with non-heat-wave periods, hospital admissions increased by 7.3% during heat waves. Specific illnesses for which admissions increased included organic illnesses, including symptomatic mental disorders; dementia; mood (affective) disorders; neurotic, stress related, and somatoform disorders; disorders of psychological development; and senility. Mortalities attributed to mental and behavioral disorders increased during heat waves in the 65- to 74-year age group and in persons with schizophrenia, schizotypal, and delusional disorders. Dementia deaths increased in those up to 65 years of age. CONCLUSION: Our results suggest that episodes of extreme heat pose a salient risk to the health and well-being of the mentally ill. RELEVANCE TO CLINICAL OR PROFESSIONAL PRACTICE: Improvements in the management and care of the mentally ill need to be addressed to avoid an increase in psychiatric morbidity and mortality as heat waves become more frequent. JF - Environmental Health Perspectives AU - Hansen, Alana AU - Bi, Peng AU - Nitschke, Monika AU - Ryan, Philip AU - Pisaniello, Dino AU - Tucker, Graeme PY - 2008 SP - 1369 EP - 1375 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Disorders KW - Mortality KW - Health KW - Hospitals KW - Regression KW - Thresholds KW - Illnesses KW - Age KW - Moods KW - Risk KW - Schizophrenia KW - Regression analysis KW - Seasons KW - Mental health KW - Copyrights KW - Design engineering KW - Ambient temperature KW - Management KW - Mental disorders KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743511911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Effect+of+Heat+Waves+on+Mental+Health+in+a+Temperate+Australian+City&rft.au=Hansen%2C+Alana%3BBi%2C+Peng%3BNitschke%2C+Monika%3BRyan%2C+Philip%3BPisaniello%2C+Dino%3BTucker%2C+Graeme&rft.aulast=Hansen&rft.aufirst=Alana&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1369&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Influence of Living Near Roadways on Spirometry and Exhaled Nitric Oxide in Elementary Schoolchildren AN - 743509552; 201004-31-0304788 (CE); 12103982 (EN) AB - BACKGROUND: Living near major roadways has been associated with an increase in respiratory symptoms, but little is known about how this relates to airway inflammation. OBJECTIVE: We assessed the effects of living near local residential roadways based on objective indicators of ventilatory function and airway inflammation. METHODS: We estimated ambient air pollution, resolved to the level of the child's neighborhood, using a land-use regression model for children 9-11 years of age. We also summed the length of roadways found within a 200-m radius of each child's neighborhood. We had measurements of both air pollution exposure and spirometry for 2,328 children, and also had measurements of exhaled nitric oxide (eNO) for 1,613 of these children. RESULTS: Each kilometer of local roadway within a 200-m radius of the home was associated with a 6.8% increase in eNO (p = 0.045). Each kilometer of any type of roadway (local, major, highway) was also associated with an increase in eNO of 10.1% (p = 0.002). Each microgram per cubic meter increase in PM2.5 was associated with a 3.9% increase in eNO (p = 0.058) and 0.70% decrease in forced vital capacity (FVC) expressed as a percentage of predicted (p = 0.39). Associations between roadway density and both forced expired volume in 1 sec and FVC were negative but not statistically significant at p 0.05. CONCLUSION: Traffic from local neighborhood roadways may cause airway inflammation as indicated by eNO. This may be a more sensitive indicator of adverse air pollution effects than traditional measures of ventilatory function. JF - Environmental Health Perspectives AU - Dales, Robert AU - Wheeler, Amanda AU - Mahmud, Mamun AU - Frescura, Anna Maria AU - Smith-Doiron, Marc AU - Nethery, Elizabeth AU - Liu, Ling PY - 2008 SP - 1423 EP - 1427 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Roadways KW - Mathematical models KW - Air pollution KW - Children KW - Airways KW - Indicators KW - Health KW - Density KW - Nitric oxide KW - Highways KW - Meters KW - Regression KW - Traffic flow KW - Land use KW - Traffic engineering KW - Measuring instruments KW - Copyrights KW - Maria KW - Age KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743509552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Influence+of+Living+Near+Roadways+on+Spirometry+and+Exhaled+Nitric+Oxide+in+Elementary+Schoolchildren&rft.au=Dales%2C+Robert%3BWheeler%2C+Amanda%3BMahmud%2C+Mamun%3BFrescura%2C+Anna+Maria%3BSmith-Doiron%2C+Marc%3BNethery%2C+Elizabeth%3BLiu%2C+Ling&rft.aulast=Dales&rft.aufirst=Robert&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1423&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Association between Traffic-Related Black Carbon Exposure and Lung Function among Urban Women AN - 743473855; 201004-31-0304800 (CE); 12103994 (EN) AB - BACKGROUND: Although a number of studies have documented the relationship between lung function and traffic-related pollution among children, few have focused on adult lung function or examined community-based populations. OBJECTIVE: We examined the relationship between black carbon (BC), a surrogate of traffic-related particles, and lung function among women in the Maternal-Infant Smoking Study of East Boston, an urban cohort in Boston, Massachusetts. METHODS: We estimated local BC levels using a validated spatiotemporal land-use regression model, derived using ambient and indoor monitor data. We examined associations between percent predicted pulmonary function and predicted BC using linear regression, adjusting for sociodemographics (individual and neighborhood levels), smoking status, occupational exposure, type of cooking fuel, and a diagnosis of asthma or chronic bronchitis. RESULTS: The sample of 272 women 18-42 years of age included 57% who self-identified as Hispanic versus 43% white, and 18% who were current smokers. Mean +/- SD predicted annual BC exposure level was 0.62 +/- 0.2 microg/m3. In adjusted analysis, BC (per interquartile range increase) was associated with a 1.1% decrease [95% confidence interval (CI), -2.5% to 0.3%] in forced expiratory volume in 1 sec, a 0.6% decrease (95% CI, -1.9% to 0.6%) in forced vital capacity, and a 3.0% decrease (95% CI, -5.8% to -0.2%) in forced mid-expiratory flow rate. We noted differential effects by smoking status in that former smokers were most affected by BC exposure, whereas current smokers were not affected. CONCLUSION: In this cohort, exposure to traffic-related BC, a component of particulate matter, independently predicted decreased lung function in urban women, when adjusting for tobacco smoke, asthma diagnosis, and socioeconomic status. JF - Environmental Health Perspectives AU - Suglia, Shakira Franco AU - Gryparis, Alexandros AU - Schwartz, Joel AU - Wright, Rosalind J PY - 2008 SP - 1333 EP - 1337 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Lungs KW - Smoking KW - Carbon KW - Asthma KW - Regression KW - Diagnosis KW - Health KW - Cooking KW - Smoke KW - Monitors KW - Heating KW - Adults KW - Children KW - Flow rate KW - Indoor KW - Populations KW - Land use KW - Occupational KW - Article KW - EE 70:Energy (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743473855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Association+between+Traffic-Related+Black+Carbon+Exposure+and+Lung+Function+among+Urban+Women&rft.au=Suglia%2C+Shakira+Franco%3BGryparis%2C+Alexandros%3BSchwartz%2C+Joel%3BWright%2C+Rosalind+J&rft.aulast=Suglia&rft.aufirst=Shakira&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Respiratory and Other Health Effects Reported in Children Exposed to the World Trade Center Disaster of 11 September 2001 AN - 743427811; 201004-31-0304790 (CE); 12103984 (EN) AB - BACKGROUND: Effects of the World Trade Center (WTC) disaster on children's respiratory health have not been definitively established. OBJECTIVE: This report describes respiratory health findings among children who were 18 years of age on 11 September 2001 (9/11) and examine associations between disaster-related exposures and respiratory health. METHODS: Children recruited for the WTC Health Registry (WTCHR) included child residents and students (kindergarten through 12th grade) in Manhattan south of Canal Street, children who were south of Chambers Street on 9/11, and adolescent disaster-related workers or volunteers. We collected data via computer-assisted telephone interviews in 2003-2004, with interview by adult proxy for children still 18 years of age at that time. We compared age-specific asthma prevalence with National Health Interview Survey estimates. RESULTS: Among 3,184 children enrolled, 28% were 5 years of age on 9/11; 34%, 5-11 years; and 39%, 12-17 years. Forty-five percent had a report of dust cloud exposure on 9/11. Half (53%) reported at least one new or worsened respiratory symptom, and 5.7% reported new asthma diagnoses. Before 9/11, age-specific asthma prevalence in enrolled children was similar to national estimates, but prevalence at interview was elevated among enrollees 5 years of age. Dust cloud exposure was associated with new asthma diagnosis (adjusted odds ratio = 2.3; 95% confidence interval, 1.5-3.5). CONCLUSIONS: Asthma prevalence after 9/11 among WTCHR enrollees 5 years of age was higher than national estimates, and new asthma diagnosis was associated with dust cloud exposure in all age groups. We will determine severity of asthma and persistence of other respiratory symptoms on follow-up surveys. JF - Environmental Health Perspectives AU - Thomas, Pauline A AU - Brackbill, Robert AU - Thalji, Lisa AU - DiGrande, Laura AU - Campolucci, Sharon AU - Thorpe, Lorna AU - Henning, Kelly PY - 2008 SP - 1383 EP - 1390 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Health KW - Asthma KW - Age KW - Exposure KW - Clouds KW - Estimates KW - Dust KW - Disasters KW - Streets KW - Diagnosis KW - Kindergartens KW - Adults KW - Adolescents KW - Proxy client servers KW - Confidence intervals KW - Elevated KW - Telephones KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743427811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Respiratory+and+Other+Health+Effects+Reported+in+Children+Exposed+to+the+World+Trade+Center+Disaster+of+11+September+2001&rft.au=Thomas%2C+Pauline+A%3BBrackbill%2C+Robert%3BThalji%2C+Lisa%3BDiGrande%2C+Laura%3BCampolucci%2C+Sharon%3BThorpe%2C+Lorna%3BHenning%2C+Kelly&rft.aulast=Thomas&rft.aufirst=Pauline&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1383&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Air Pollution and Odor in Communities Near Industrial Swine Operations AN - 743423962; 201004-31-0304795 (CE); 12103989 (EN) AB - BACKGROUND: Odors can affect health and quality of life. Industrialized animal agriculture creates odorant compounds that are components of a mixture of agents that could trigger symptoms reported by neighbors of livestock operations. OBJECTIVE: We quantified swine odor episodes reported by neighbors and the relationships of these episodes with environmental measurements. METHODS: Between September 2003 and September 2005, 101 nonsmoking volunteers living within 1.5 mi of industrial swine operations in 16 neighborhoods in eastern North Carolina completed twice-daily odor diaries for approximately 2 weeks. Meteorological conditions, hydrogen sulfide, and particulate matter or= 10 microm in aerodynamic diameter (PM10) were monitored in each neighborhood. We used mixed models to partition odor variance within and between people and between neighborhoods, and to quantify relationships between environmental factors and odor. RESULTS: Participants reported 1,655 episodes of swine odor. In nine neighborhoods, odor was reported on more than half of study-days. Odor ratings were related to temperature, PM10, and semivolatile PM10 in standard but not mixed models. In mixed models, odor increased 0.15 +/- 0.05 units (mean +/- SE) for a 1-ppb increase in H2S, and 0.45 +/- 0.14 units for a 10-microg/m3 increase in PM10 at wind speeds 6.75 miles per hour. The odds of reporting a change in daily activities due to odor increased 62% for each unit increase in average odor during the prior 12 hr (t-value = 7.17). CONCLUSIONS: This study indicates that malodor from swine operations is commonly present in these communities and that the odors reported by neighbors are related to objective environmental measurements and interruption of activities of daily life. JF - Environmental Health Perspectives AU - Wing, Steve AU - Horton, Rachel Avery AU - Marshall, Stephen W AU - Thu, Kendall AU - Tajik, Mansoureh AU - Schinasi, Leah AU - Schiffman, Susan S PY - 2008 SP - 1362 EP - 1368 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Odors KW - Swine KW - Health KW - Mathematical models KW - Communities KW - Air pollution KW - Ratings KW - Wings (aircraft) KW - Reporting KW - Livestock KW - Variance KW - Partitions KW - Diaries KW - Odorants KW - Standards KW - Agriculture KW - Copyrights KW - Hydrogen sulfide KW - Interruption KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743423962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Air+Pollution+and+Odor+in+Communities+Near+Industrial+Swine+Operations&rft.au=Wing%2C+Steve%3BHorton%2C+Rachel+Avery%3BMarshall%2C+Stephen+W%3BThu%2C+Kendall%3BTajik%2C+Mansoureh%3BSchinasi%2C+Leah%3BSchiffman%2C+Susan+S&rft.aulast=Wing&rft.aufirst=Steve&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1362&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Urinary Porphyrin Excretion in Children is Associated with Exposure to Organochlorine Compounds AN - 743421729; 201004-31-0304793 (CE); 12103987 (EN) AB - BACKGROUND: Hexachlorobenzene (HCB) and other organochlorines induce porphyria cutanea tarda (PCT) in animal studies. Evidence in humans, however, is contradictory. In neonates and adults from a population historically highly exposed to HCB (Flix, Catalonia, Spain), no relation with PCT or with porphyrin excretion was found. OBJECTIVES: We aimed to analyze the association between urinary porphyrin excretion and exposure to HCB and other organochlorinated compounds in children 4 years of age. METHODS: Our birth cohort included all newborns from Flix and the five surrounding towns (where no airborne pollution occurred). Among the 68 children with porphyrins we measured in cord blood, 52 children 4 years of age provided blood to measure organochlorine compounds, hair for methylmercury, and urine for porphyrin excretion pattern. RESULTS: Quantitative porphyrin excretion was within the normal values. However, total porphyrins, coproporphyrin I (CPI), and coproporphyrin III (CPIII) adjusted to creatinine excretion increased with increasing levels of HCB, 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p'-DDE), 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p'-DDT), and polychlorinated biphenyl congener 153 (PCB-153). We found no association with methylmercury. When we fitted multiple pollutant models, p,p'-DDE had the strongest association. We found these associations in children from both Flix and other towns, and they were independent of breast-feeding and of organochlorine and porphyrin levels at birth. CONCLUSION: HCB at current levels did not induce porphyria or increase uroporphyrins. However, the increase of urinary coproporphyrins suggests an incipient toxic effect of the organochlorines, especially for p,p'-DDE, on the hepatic heme-synthesis pathway that differs from the major effects seen in PCT. JF - Environmental Health Perspectives AU - Sunyer, Jordi AU - Alvarez-Pedrerol, Mar AU - To-Figueras, Jordi AU - Ribas-Fito, Nuria AU - Grimalt, Joan O AU - Herrero, Carmen PY - 2008 SP - 1407 EP - 1410 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Porphyrins KW - Excretion KW - Children KW - Towns KW - Health KW - Birth KW - Organochlorine compounds KW - Blood KW - Age KW - Adults KW - Toxic KW - Mathematical models KW - Congeners KW - Rope KW - Copyrights KW - Polychlorinated biphenyls KW - Hair KW - Creatinine KW - Pathways KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743421729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Urinary+Porphyrin+Excretion+in+Children+is+Associated+with+Exposure+to+Organochlorine+Compounds&rft.au=Sunyer%2C+Jordi%3BAlvarez-Pedrerol%2C+Mar%3BTo-Figueras%2C+Jordi%3BRibas-Fito%2C+Nuria%3BGrimalt%2C+Joan+O%3BHerrero%2C+Carmen&rft.aulast=Sunyer&rft.aufirst=Jordi&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1407&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Urinary Cadmium and Osteoporosis in U.S. Women [Greater-Than Or Equal To] 50 Years of Age: NHANES 1988-1994 and 1999-2004 AN - 743421699; 201004-31-0304725 (CE); 12103909 (EN) AB - BACKGROUND: Urinary cadmium (U-Cd) has been associated with decreased peripheral bone mineral density (BMD) and osteoporosis. This association, however, has not been confirmed using femoral BMD, the international standard for diagnosing osteoporosis, at levels 1.0 microg Cd/g creatinine. OBJECTIVES: Our goal was to investigate the statistical association between U-Cd, at levels or= 1 microg/g creatinine, and osteoporosis, as indicated by hip BMD and self-report in a population-based sample of U.S. women or= 50 years of age. METHODS: We drew data from the National Health and Nutrition Examination Surveys for 1988-1994 (n = 3,207) and 1999-2004 (n = 1,051). Osteoporosis was indicated by hip BMD cutoffs based on the international standard and self-report of physician diagnosis. We analyzed U-Cd levels for association with osteoporosis using multiple logistic regression. RESULTS: Women or= 50 years of age with U-Cd levels between 0.50 and 1.00 microg/g creatinine were at 43% greater risk for hip-BMD-defined osteoporosis, relative to those with levels or= 0.50 microg/g (odds ratio = 1.43; 95% confidence interval, 1.02-2.00; p = 0.04). We observed similar effect estimates using self-report of physician-diagnosed osteoporosis. Smokers did not show a statistically increased risk. CONCLUSIONS: Results suggest that U.S. women are at risk for osteoporosis at U-Cd levels below the U.S. Occupational Safety and Health Administration's 3-microg/g safety standard. Given null findings among smokers, dietary Cd, rather than tobacco, is the likely source of Cd-related osteoporosis risk for the U.S. female population or= 50 years of age. JF - Environmental Health Perspectives AU - Gallagher, Carolyn M AU - Kovach, John S AU - Meliker, Jaymie R PY - 2008 SP - 1338 EP - 1343 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Osteoporosis KW - Cadmium KW - Risk KW - Health KW - Age KW - Standards KW - Creatinine KW - Density KW - Bones KW - Statistical methods KW - Nutrition KW - Samples KW - Regression KW - Occupational safety KW - Surgical implants KW - Estimates KW - Diagnosis KW - Statistical analysis KW - Biomedical materials KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743421699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Urinary+Cadmium+and+Osteoporosis+in+U.S.+Women+%5BGreater-Than+Or+Equal+To%5D+50+Years+of+Age%3A+NHANES+1988-1994+and+1999-2004&rft.au=Gallagher%2C+Carolyn+M%3BKovach%2C+John+S%3BMeliker%2C+Jaymie+R&rft.aulast=Gallagher&rft.aufirst=Carolyn&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1338&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Margin-of-Exposure Approach to Assessment of Noncancer Risks of Dioxins Based on Human Exposure and Response Data AN - 743309416; 201004-31-0304799 (CE); 12103993 (EN) AB - BACKGROUND: Risk assessment of human environmental exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDFs) and other dioxin-like compounds is complicated by several factors, including limitations in measuring intakes because of the low concentrations of these compounds in foods and the environment and interspecies differences in pharmacokinetics and responses. OBJECTIVES: We examined the feasibility of relying directly on human studies of exposure and potential responses to PCDD/PCDFs and related compounds in terms of measured lipid-adjusted concentrations to assess margin of exposure (MOE) in a quantitative, benchmark dose (BMD)-based framework using representative exposure and selected response data sets. METHODS: We characterize estimated central tendency and upper-bound general U.S. population lipid-adjusted concentrations of PCDD/PCDFs from the 1970s and early 2000s based on available data sets. Estimates of benchmark concentrations for three example responses of interest (induction of cytochrome P4501A2 activity, dental anomalies, and neonatal thyroid hormone alterations) were derived based on selected human studies. RESULTS: The exposure data sets indicate that current serum lipid concentrations in young adults are approximately 6- to 7-fold lower than 1970s-era concentrations. Estimated MOEs for each end point based on current serum lipid concentrations range from 10 for neonatal thyroid hormone concentrations to 100 for dental anomalies-approximately 6-fold greater than would have existed during the 1970s. CONCLUSIONS: Human studies of dioxin exposure and outcomes can be used in a BMD framework for quantitative assessments of MOE. Incomplete exposure characterization can complicate the use of such studies in a BMD framework. JF - Environmental Health Perspectives AU - Aylward, Lesa L AU - Goodman, Julie E AU - Charnley, Gail AU - Rhomberg, Lorenz R PY - 2008 SP - 1344 EP - 1351 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Human KW - Data sets KW - Assessments KW - Lipids KW - Hormones KW - Health KW - Ecological risk assessment KW - Serums KW - Dioxins KW - Benchmarking KW - Risk KW - Adults KW - Estimates KW - Low concentrations KW - Cytochromes KW - Copyrights KW - Risk assessment KW - Foods KW - Feasibility KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743309416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Margin-of-Exposure+Approach+to+Assessment+of+Noncancer+Risks+of+Dioxins+Based+on+Human+Exposure+and+Response+Data&rft.au=Aylward%2C+Lesa+L%3BGoodman%2C+Julie+E%3BCharnley%2C+Gail%3BRhomberg%2C+Lorenz+R&rft.aulast=Aylward&rft.aufirst=Lesa&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1344&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Marked Liver Tumorigenesis by Helicobacter hepaticus Requires Perinatal Exposure AN - 743300831; 201004-31-0304798 (CE); 12103992 (EN) AB - BACKGROUND: Although severe hepatitis and liver tumors occur in a high percentage of A/J male mice naturally infected with Helicobacter hepaticus, these effects have not been observed after injection of adult mice with the bacteria. OBJECTIVES: We tested the hypothesis that perinatal exposure to the bacteria is required for liver tumorigenesis. METHODS: A/J female mice were infected by intragastric (ig) or intraperitoneal (ip) treatment with 1.5 x 10(8) H. hepaticus before pregnancy. We examined offspring at progressive time intervals, including some kept until natural death in old age. A/J, BALB/c, and C57BL/6 weanling male mice were similarly treated ig with the bacteria and observed for up to 2 years. RESULTS: After ip bacterial infection of A/J females, 41% of their male offspring developed hepatitis and 33% had hepatocellular tumors, including 18% with hepatocellular carcinoma. Treatment by the ig route resulted in a similar incidence of hepatitis in offspring (35%) but fewer total liver tumors (8%) and carcinomas (4%). By contrast, ig instillation of H. hepaticus in weanling A/J, C57BL/6, or BALB/c mice resulted in low incidence of hepatitis (0-20%) and few liver tumors, despite presence of bacteria confirmed in feces. CONCLUSIONS: Results indicate that a high incidence of liver tumors in mice infected with H. hepaticus requires perinatal exposure. Contributing perinatal factors could include known high sensitivity of neonatal liver to tumor initiation, and/or modulation of immune response to the bacterium or its toxins. Mechanisms of human perinatal sensitivity to such phenomena can be studied with this model. JF - Environmental Health Perspectives AU - Diwan, Bhalchandra A AU - Sipowicz, Marek AU - Logsdon, Daniel AU - Gorelick, Peter AU - Anver, Miriam R AU - Kasprzak, Kazimierz S AU - Anderson, Lucy M PY - 2008 SP - 1352 EP - 1356 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Bacteria KW - Liver KW - Mice KW - Tumors KW - Hepatitis KW - Incidence KW - Males KW - Health KW - Mathematical models KW - Females KW - Modulation KW - Adults KW - Pregnancy KW - Intervals KW - Toxins KW - Copyrights KW - Human KW - Age KW - Death KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743300831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Marked+Liver+Tumorigenesis+by+Helicobacter+hepaticus+Requires+Perinatal+Exposure&rft.au=Diwan%2C+Bhalchandra+A%3BSipowicz%2C+Marek%3BLogsdon%2C+Daniel%3BGorelick%2C+Peter%3BAnver%2C+Miriam+R%3BKasprzak%2C+Kazimierz+S%3BAnderson%2C+Lucy+M&rft.aulast=Diwan&rft.aufirst=Bhalchandra&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Impairment of NO-Dependent Relaxation in Intralobar Pulmonary Arteries: Comparison of Urban Particulate Matter and Manufactured Nanoparticles AN - 743296789; 201004-31-0304804 (CE); 12103998 (EN) AB - BACKGROUND AND OBJECTIVES: Because pulmonary circulation is the primary vascular target of inhaled particulate matter (PM), and nitric oxide is a major vasculoprotective agent, in this study we investigated the effect of various particles on the NO-cyclic guanosine monophosphate (cGMP) pathway in pulmonary arteries. METHODS: We used intrapulmonary arteries and/or endothelial cells, either exposed in vitro to particles or removed from PM-instilled animals for assessment of vasomotricity, cGMP and reactive oxygen species (ROS) levels, and cytokine/chemokine release. RESULTS: Endothelial NO-dependent relaxation and cGMP accumulation induced by acetylcholine (ACh) were both decreased after 24 hr exposure of rat intrapulmonary arteries to standard reference material 1648 (SRM1648; urban PM). Relaxation due to NO donors was also decreased by SRM1648, whereas responsiveness to cGMP analogue remained unaffected. Unlike SRM1648, ultrafine carbon black and ultrafine and fine titanium dioxide (TiO2) manufactured particles did not impair NO-mediated relaxation. SRM1648-induced decrease in relaxation response to ACh was prevented by dexamethasone (an anti-inflammatory agent) but not by antioxidants. Accordingly, SRM1648 increased the release of proinflammatory mediators (tumor necrosis factor-alpha, interleukin-8) from intrapulmonary arteries or pulmonary artery endothelial cells, but did not elevate ROS levels within intrapulmonary arteries. Decreased relaxation in response to ACh was also evidenced in intrapulmonary arteries removed from rats intratracheally instilled with SRM1648, but not with fine TiO2. CONCLUSION: In contrast to manufactured particles (including nanoparticles), urban PM impairs NO but not cGMP responsiveness in intrapulmonary arteries. We attribute this effect to oxidative-stress-independent inflammatory response, resulting in decreased guanylyl cyclase activation by NO. Such impairment of the NO pathway may contribute to urban-PM-induced cardiovascular dysfunction. JF - Environmental Health Perspectives AU - Courtois, Arnaud AU - Andujar, Pascal AU - Ladeiro, Yannick AU - Baudrimont, Isabelle AU - Delannoy, Estelle AU - Leblais, Veronique AU - Begueret, Hugues AU - Galland, Marie Annick Billon AU - Brochard, Patrick AU - Marano, Francelyne AU - Marthan, Roger AU - Muller, Bernard PY - 2008 SP - 1294 EP - 1299 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Arteries KW - Titanium dioxide KW - Impairment KW - Endothelial cells KW - Health KW - Ultrafines KW - Pathways KW - Nanoparticles KW - Activation KW - Assessments KW - Guanosines KW - Cytokines KW - Inflammatory response KW - Carbon black KW - In vitro testing KW - Dexamethasone KW - Tumors KW - Antioxidants KW - Analogue KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743296789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Impairment+of+NO-Dependent+Relaxation+in+Intralobar+Pulmonary+Arteries%3A+Comparison+of+Urban+Particulate+Matter+and+Manufactured+Nanoparticles&rft.au=Courtois%2C+Arnaud%3BAndujar%2C+Pascal%3BLadeiro%2C+Yannick%3BBaudrimont%2C+Isabelle%3BDelannoy%2C+Estelle%3BLeblais%2C+Veronique%3BBegueret%2C+Hugues%3BGalland%2C+Marie+Annick+Billon%3BBrochard%2C+Patrick%3BMarano%2C+Francelyne%3BMarthan%2C+Roger%3BMuller%2C+Bernard&rft.aulast=Courtois&rft.aufirst=Arnaud&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1294&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Lung Cancer and Vehicle Exhaust in Trucking Industry Workers AN - 743265476; 201004-31-0304801 (CE); 12103995 (EN) AB - BACKGROUND: An elevated risk of lung cancer in truck drivers has been attributed to diesel exhaust exposure. Interpretation of these studies specifically implicating diesel exhaust as a carcinogen has been limited because of limited exposure measurements and lack of work records relating job title to exposure-related job duties. OBJECTIVES: We established a large retrospective cohort of trucking company workers to assess the association of lung cancer mortality and measures of vehicle exhaust exposure. METHODS: Work records were obtained for 31,135 male workers employed in the unionized U.S. trucking industry in 1985. We assessed lung cancer mortality through 2000 using the National Death Index, and we used an industrial hygiene review and current exposure measurements to identify jobs associated with current and historical use of diesel-, gas-, and propane-powered vehicles. We indirectly adjusted for cigarette smoking based on an industry survey. RESULTS: Adjusting for age and a healthy-worker survivor effect, lung cancer hazard ratios were elevated in workers with jobs associated with regular exposure to vehicle exhaust. Mortality risk increased linearly with years of employment and was similar across job categories despite different current and historical patterns of exhaust-related particulate matter from diesel trucks, city and highway traffic, and loading dock operations. Smoking behavior did not explain variations in lung cancer risk. CONCLUSIONS: Trucking industry workers who have had regular exposure to vehicle exhaust from diesel and other types of vehicles on highways, city streets, and loading docks have an elevated risk of lung cancer with increasing years of work. JF - Environmental Health Perspectives AU - Garshick, Eric AU - Laden, Francine AU - Hart, Jaime E AU - Rosner, Bernard AU - Davis, Mary E AU - Eisen, Ellen A AU - Smith, Thomas J PY - 2008 SP - 1327 EP - 1332 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Trucks KW - Cancer KW - Lungs KW - Exhaust KW - Risk KW - Diesel KW - Diesel fuels KW - Freight transportation KW - Mortality KW - Elevated KW - Highways KW - Docks KW - Health KW - Smoking KW - Categories KW - Carcinogens KW - Streets KW - Drivers KW - Traffic flow KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743265476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Lung+Cancer+and+Vehicle+Exhaust+in+Trucking+Industry+Workers&rft.au=Garshick%2C+Eric%3BLaden%2C+Francine%3BHart%2C+Jaime+E%3BRosner%2C+Bernard%3BDavis%2C+Mary+E%3BEisen%2C+Ellen+A%3BSmith%2C+Thomas+J&rft.aulast=Garshick&rft.aufirst=Eric&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1327&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Longitudinal Study of Indoor Nitrogen Dioxide Levels and Respiratory Symptoms in Inner-City Children with Asthma AN - 743264761; 201004-31-0304785 (CE); 12103979 (EN) AB - BACKGROUND: The effect of indoor nitrogen dioxide concentrations on asthma morbidity among inner-city preschool children is uncertain. OBJECTIVES: Our goal was to estimate the effect of indoor NO2 concentrations on asthma morbidity in an inner-city population while adjusting for other indoor pollutants. METHODS: We recruited 150 children (2-6 years of age) with physician-diagnosed asthma from inner-city Baltimore, Maryland. Indoor air was monitored over a 72-hr period in the children's bedrooms at baseline and 3 and 6 months. At each visit, the child's caregiver completed a questionnaire assessing asthma symptoms over the previous 2 weeks and recent health care utilization. RESULTS: Children were 58% male, 91% African American, and 42% from households with annual income $25,000; 63% had persistent asthma symptoms. The mean (+/- SD) in-home NO2 concentration was 30.0 +/- 33.7 (range, 2.9-394.0) ppb. The presence of a gas stove and the use of a space heater or oven/stove for heat were independently associated with higher NO2 concentrations. Each 20-ppb increase in NO2 exposure was associated significantly with an increase in the number of days with limited speech [incidence rate ratio (IRR) = 1.15; 95% confidence interval (CI), 1.05-1.25], cough (IRR = 1.10; 95% CI, 1.02-1.18), and nocturnal symptoms (IRR = 1.09; 95% CI, 1.02-1.16), after adjustment for potential confounders. NO2 concentrations were not associated with increased health care utilization. CONCLUSIONS: Higher indoor NO2 concentrations were associated with increased asthma symptoms in preschool inner-city children. Interventions aimed at lowering NO2 concentrations in inner-city homes may reduce asthma morbidity in this vulnerable population. JF - Environmental Health Perspectives AU - Hansel, Nadia N AU - Breysse, Patrick N AU - McCormack, Meredith C AU - Matsui, Elizabeth C AU - Curtin-Brosnan, Jean AU - Williams, D'Ann L AU - Moore, Jennifer L AU - Cuhran, Jennifer L AU - Diette, Gregory B PY - 2008 SP - 1428 EP - 1432 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Nitrogen dioxide KW - Asthma KW - Indoor KW - Children KW - Stoves KW - Health KW - Health care KW - Utilization KW - Heaters KW - Bedrooms KW - Ovens KW - Households KW - Estimates KW - Preschool children KW - Cough KW - Confidence intervals KW - Speech KW - Incidence KW - Males KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743264761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Longitudinal+Study+of+Indoor+Nitrogen+Dioxide+Levels+and+Respiratory+Symptoms+in+Inner-City+Children+with+Asthma&rft.au=Hansel%2C+Nadia+N%3BBreysse%2C+Patrick+N%3BMcCormack%2C+Meredith+C%3BMatsui%2C+Elizabeth+C%3BCurtin-Brosnan%2C+Jean%3BWilliams%2C+D%27Ann+L%3BMoore%2C+Jennifer+L%3BCuhran%2C+Jennifer+L%3BDiette%2C+Gregory+B&rft.aulast=Hansel&rft.aufirst=Nadia&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1428&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Lead Exposures in U.S. Children, 2008: Implications for Prevention AN - 743257037; 201004-31-0304806 (CE); 12104000 (EN) AB - OBJECTIVE: We reviewed the sources of lead in the environments of U.S. children, contributions to children's blood lead levels, source elimination and control efforts, and existing federal authorities. Our context is the U.S. public health goal to eliminate pediatric elevated blood lead levels (EBLs) by 2010. DATA SOURCES: National, state, and local exposure assessments over the past half century have identified risk factors for EBLs among U.S. children, including age, race, income, age and location of housing, parental occupation, and season. DATA EXTRACTION AND SYNTHESIS: Recent national policies have greatly reduced lead exposure among U.S. children, but even very low exposure levels compromise children's later intellectual development and lifetime achievement. No threshold for these effects has been demonstrated. Although lead paint and dust may still account for up to 70% of EBLs in U.S. children, the U.S. Centers for Disease Control and Prevention estimates that or=30% of current EBLs do not have an immediate lead paint source, and numerous studies indicate that lead exposures result from multiple sources. EBLs and even deaths have been associated with inadequately controlled sources including ethnic remedies and goods, consumer products, and food-related items such as ceramics. Lead in public drinking water and in older urban centers remain exposure sources in many areas. CONCLUSIONS: Achieving the 2010 goal requires maintaining current efforts, especially programs addressing lead paint, while developing interventions that prevent exposure before children are poisoned. It also requires active collaboration across all levels of government to identify and control all potential sources of lead exposure, as well as primary prevention. JF - Environmental Health Perspectives AU - Levin, Ronnie AU - Brown, Mary Jean AU - Kashtock, Michael E AU - Jacobs, David E AU - Whelan, Elizabeth A AU - Rodman, Joanne AU - Schock, Michael R AU - Padilla, Alma AU - Sinks, Thomas PY - 2008 SP - 1285 EP - 1293 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Exposure KW - Painting KW - Health KW - Age KW - Blood KW - Active control KW - Remedies KW - Policies KW - Assessments KW - Drinking water KW - Position (location) KW - Risk KW - Disease control KW - Extraction KW - Occupation KW - Data sources KW - Estimates KW - Ethnic KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743257037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Lead+Exposures+in+U.S.+Children%2C+2008%3A+Implications+for+Prevention&rft.au=Levin%2C+Ronnie%3BBrown%2C+Mary+Jean%3BKashtock%2C+Michael+E%3BJacobs%2C+David+E%3BWhelan%2C+Elizabeth+A%3BRodman%2C+Joanne%3BSchock%2C+Michael+R%3BPadilla%2C+Alma%3BSinks%2C+Thomas&rft.aulast=Levin&rft.aufirst=Ronnie&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1285&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Hydroxylated Metabolites of the Polybrominated Diphenyl Ether Mixture DE-71 Are Weak Estrogen Receptor-[alpha] Ligands AN - 743244906; 201004-31-0304726 (CE); 12103910 (EN) AB - BACKGROUND: Polybrominated diphenyl ethers (PBDEs) are widely found in the environment and are suspected endocrine disruptors. We previously identified six hydroxylated metabolites of PBDE (OH-PBDEs) in treated mice. OBJECTIVE: We tested the hypothesis that OH-PBDEs would interact with and alter activity of estrogen receptor-alpha (ER-alpha). METHODS: We tested estrogenicity using two assays: 3H-estradiol (3H-E2) displacement from recombinant ER-alpha and induction of reporter gene (ERE-luciferase) in cultured cells. We incubated the PBDE mixture DE-71 with rat liver microsomes and tested the resultant metabolite mixture for estrogenic activity. We also determined relative estrogenic potential of individual hydroxylated PBDE congeners. RESULTS: Reporter gene activity was increased by DE-71 that had been subjected to microsomal metabolism. DE-71 did not displace E2 from ER-alpha, but all six of the OH-PBDE metabolites did. para-Hydroxylated metabolites displayed a 10- to 30-fold higher affinity for ER-alpha compared with ortho-hydroxylated PBDEs, and one produced a maximal effect 30% higher than that produced by E2. Coadministration of E2 and DE-71, or certain of its metabolites, yielded reporter activity greater than either chemical alone. Two ortho-OH-PBDEs were antiestrogenic in the reporter assay. CONCLUSIONS: The observations--that the DE-71 mixture did not displace 3H-E2 from ER-alpha while the hydroxylated metabolites did-suggest that the weak estrogenic effects of DE-71 are due to metabolic activation of individual congeners. However, the behavior of DE-71 and its metabolites, when co-administered with E2, suggest a secondary, undetermined mechanism from classical ER-alpha activation. JF - Environmental Health Perspectives AU - Mercado-Feliciano, Minerva AU - Bigsby, Robert M PY - 2008 SP - 1315 EP - 1321 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Metabolites KW - Displacement KW - Activation KW - Ethers KW - Estrogens KW - Health KW - Congeners KW - Genes KW - Assaying KW - Recombinant KW - Mice KW - Endocrine disruptors KW - Affinity KW - Copyrights KW - Resultants KW - Metabolism KW - Liver KW - Ligands KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743244906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Hydroxylated+Metabolites+of+the+Polybrominated+Diphenyl+Ether+Mixture+DE-71+Are+Weak+Estrogen+Receptor-%5Balpha%5D+Ligands&rft.au=Mercado-Feliciano%2C+Minerva%3BBigsby%2C+Robert+M&rft.aulast=Mercado-Feliciano&rft.aufirst=Minerva&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1315&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Developmental Lead Exposure Induces Tactile Defensiveness in Rhesus Monkeys (Macaca Mulatta) AN - 743184049; 201004-31-0304802 (CE); 12103996 (EN) AB - BACKGROUND: Tactile defensiveness in children is associated with difficult social relations, emotional dysregulation, and inattention. However, there are no studies of lead exposure and tactile defensiveness in children or animals in spite of the fact that lead exposure is also associated with inattention and emotional dysregulation. OBJECTIVES: In this study we tested whether lead exposure induces tactile defensiveness in rhesus monkeys. METHODS: We tested 61 monkeys from a 3 (no lead, 1-year lead, 2-year lead) x 2 (succimer chelation or not) factorial experiment for tactile defensiveness at 4 years of age. Lead-treated monkeys had been orally administered lead in a daily milk solution from 8 days of life to either 1 or 2 years of age to produce blood lead levels of 35-40 mg/dL. Succimer chelation therapy or placebo was administered at 1 year of age. We measured tactile defensiveness using six repeated trials of each of three textures as a swipe to the cheek and neck. RESULTS: Lead-exposed monkeys showed higher negative responses to repeated tactile stimulation compared with controls. Blood lead during the first 3 months of life was positively correlated with the negative response on the tactile defensiveness test. There was an interaction of lead exposure x succimer chelation x trials, but it is not clear that succimer chelation was beneficial with respect to tactile defensiveness. CONCLUSIONS: This is the first report to implicate lead as a potential cause of tactile defensiveness. Research should examine whether lead exposure is associated with tactile defensiveness in children. JF - Environmental Health Perspectives AU - Moore, Colleen F AU - Gajewski, Lisa L AU - Laughlin, Nellie K AU - Luck, Melissa L AU - Larson, Julie A AU - Schneider, Mary L PY - 2008 SP - 1322 EP - 1326 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Tactile KW - Monkeys KW - Chelation KW - Texture KW - Children KW - Age KW - Health KW - Blood KW - Surface layer KW - Milk KW - Factorial experiments KW - Correlation KW - Therapy KW - Stimulation KW - Control equipment KW - Copyrights KW - Animals KW - Necks KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743184049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Developmental+Lead+Exposure+Induces+Tactile+Defensiveness+in+Rhesus+Monkeys+%28Macaca+Mulatta%29&rft.au=Moore%2C+Colleen+F%3BGajewski%2C+Lisa+L%3BLaughlin%2C+Nellie+K%3BLuck%2C+Melissa+L%3BLarson%2C+Julie+A%3BSchneider%2C+Mary+L&rft.aulast=Moore&rft.aufirst=Colleen&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1322&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Case-Control Study of Blood Lead Levels and Attention Deficit Hyperactivity Disorder in Chinese Children AN - 743153482; 201004-31-0304792 (CE); 12103986 (EN) AB - BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) and lead exposure are high-prevalence conditions among children. OBJECTIVE: Our goal was to investigate the association between ADHD and blood lead levels (BLLs) in Chinese children, adjusting for known ADHD risk factors and potential confounding variables. METHODS: We conducted a pair-matching case-control study with 630 ADHD cases and 630 non-ADHD controls 4-12 years of age, matched on the same age, sex, and socioeconomic status. The case and control children were systematically evaluated via structured diagnostic interviews, including caregiver interviews, based on the Diagnostic and Statistical Manual of Mental Disorders, 4th ed., revised criteria (DSM-IV-R). We evaluated the association between BLLs and ADHD using the Pearson chi-square test for categorical variables and the Student t-test for continuous data. We then performed conditional multiple variables logistic regression analyses with backward stepwise selection to predict risk factors for ADHD. RESULTS: There was a significant difference in BLLs between ADHD cases and controls. ADHD cases were more likely to have been exposed to lead during childhood than the non-ADHD control subjects, with adjustment for other known risk factors [children with BLLs or= 10 microg/dL vs. or= 5 microg/dL; OR = 6.0; 95% confidence interval (CI) = 4.10-8.77, p 0.01; 5-10 microg/dL vs.or= 5 microg/dL, OR = 4.9; 95% CI = 3.47-6.98, p 0.01]. These results were not modified by age and sex variables. CONCLUSIONS: This was the largest sample size case-control study to date to study the association between BLLs and ADHD in Chinese children. ADHD may be an additional deleterious outcome of lead exposure during childhood, even when BLLs are 10 microg/dL. JF - Environmental Health Perspectives AU - Wang, Hui-Li AU - Chen, Xiang-Tao AU - Yang, Bin AU - Ma, Fang-Li AU - Wang, Shu AU - Tang, Ming-Liang AU - Hao, Ming-Gao AU - Ruan, Di-Yun PY - 2008 SP - 1401 EP - 1406 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Control equipment KW - Risk KW - Age KW - Diagnostic systems KW - Disorders KW - Health KW - Sex KW - Blood KW - Statistical methods KW - Samples KW - Statistical analysis KW - Criteria KW - Regression analysis KW - Confidence intervals KW - Copyrights KW - Logistics KW - Mental disorders KW - Exposure KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743153482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Case-Control+Study+of+Blood+Lead+Levels+and+Attention+Deficit+Hyperactivity+Disorder+in+Chinese+Children&rft.au=Wang%2C+Hui-Li%3BChen%2C+Xiang-Tao%3BYang%2C+Bin%3BMa%2C+Fang-Li%3BWang%2C+Shu%3BTang%2C+Ming-Liang%3BHao%2C+Ming-Gao%3BRuan%2C+Di-Yun&rft.aulast=Wang&rft.aufirst=Hui-Li&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Community-Based Participatory Research: A Vehicle to Promote Public Engagement for Environmental Health in China AN - 743129595; 201004-31-0304807 (CE); 12104001 (EN) AB - BACKGROUND: In the past 25 years, China has experienced remarkable economic growth and rapid agricultural-to-industrial and rural-to-urban transitions. As a consequence, China now faces many daunting environmental challenges that are significantly affecting human health and quality of life, including indoor and outdoor air pollution, water pollution, deforestation, loss of agricultural land, and sustainability. Chinese government leaders have recently emphasized the need for better environmental protection practices along with interventions involving strong public participation. OBJECTIVES: Community-based participatory research (CBPR) is a collaborative approach to research that involves community members, organizational representatives, and researchers as equal participants in all phases of the research process. Over the past 15 years, CBPR has gained recognition and acceptance and is now valued as a means to effect change and provide scientific knowledge relevant to human health and the environment. In this article we highlight the success of CBPR in the United States and suggest that it could be a useful model for addressing environmental health problems in the People's Republic of China. DISCUSSION: CBPR can reduce the tension between science and society by promoting genuine communication, by enabling scientists and administrators to listen and respond to the public, by allowing communities to help shape the research agenda, and by increasing accountability of researchers and governments to the public. CONCLUSIONS: CBPR can potentially help improve environmental health in China, but it is likely to take a different form than it has in the West because the government will be leading the way. JF - Environmental Health Perspectives AU - Ali, Robbie AU - Olden, Kenneth AU - Xu, Shunqing PY - 2008 SP - 1281 EP - 1284 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Governments KW - Communities KW - Agronomy KW - Human KW - Economics KW - Air pollution KW - Sustainability KW - Rapids KW - Water pollution KW - Land KW - Indoor KW - Recognition KW - Farmlands KW - Copyrights KW - Deforestation KW - Acceptance KW - Phases KW - Scientists KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743129595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Community-Based+Participatory+Research%3A+A+Vehicle+to+Promote+Public+Engagement+for+Environmental+Health+in+China&rft.au=Ali%2C+Robbie%3BOlden%2C+Kenneth%3BXu%2C+Shunqing&rft.aulast=Ali&rft.aufirst=Robbie&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1281&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Birth Delivery Mode Modifies the Associations between Prenatal Polychlorinated Biphenyl (PCB) and Polybrominated Diphenyl Ether (PBDE) and Neonatal Thyroid Hormone Levels AN - 743102850; 201004-31-0304789 (CE); 12103983 (EN) AB - BACKGROUND: Developing infants may be especially sensitive to hormone disruption from chemicals including polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). OBJECTIVE: We investigated relationships between cord serum levels of PCBs and PBDEs and thyroid hormones measured in cord blood serum and neonatal blood spots. METHODS: We measured PCBs and PBDEs, thyrotropin (TSH), thyroxine (T4) and free T4 (FT4) in cord blood serum from 297 infants who were delivered at the Johns Hopkins Hospital in 2004-2005. We abstracted results of total T4 (TT4) measured in blood spots collected in the hospital and at neonatal visits. We used delivery mode (augmented vaginal deliveries and nonelective cesarean deliveries) as a surrogate for intrapartum stress, which is known to alter cord blood thyroid hormones. RESULTS: In the full study population, no compounds were associated with a change in average TSH, FT4, or TT4. BDE-100 was associated with increased odds of low cord TT4, BDE-153 with increased odds of low cord TT4 and FT4, and no compounds were associated with increased odds of high TSH. For infants born by spontaneous, vaginal, unassisted deliveries, PCBs were associated with lower cord TT4 and FT4 and lower TT4 measured in neonatal blood spots. PBDEs showed consistent but mainly nonsignificant negative associations with TT4 and FT4 measurements. CONCLUSIONS: Prenatal PCB and PBDE exposures were associated with reduced TT4 and FT4 levels among infants born by spontaneous, unassisted vaginal delivery. Intrapartum stress associated with delivery mode may mask hormonal effects of PCBs and PBDEs. JF - Environmental Health Perspectives AU - Herbstman, Julie B AU - Sjoedin, Andreas AU - Apelberg, Benjamin J AU - Witter, Frank R AU - Halden, Rolf U AU - Patterson, Donald G AU - Panny, Susan R AU - Needham, Larry L AU - Goldman, Lynn R PY - 2008 SP - 1376 EP - 1382 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Rope KW - Blood KW - Infants KW - Hormones KW - Spots KW - Serums KW - Ethers KW - Circuit boards KW - Spontaneous KW - Health KW - Hospitals KW - Polychlorinated biphenyls KW - Printed circuits KW - Stresses KW - Thyroxine KW - Masks KW - Copyrights KW - Disruption KW - Birth KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743102850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Birth+Delivery+Mode+Modifies+the+Associations+between+Prenatal+Polychlorinated+Biphenyl+%28PCB%29+and+Polybrominated+Diphenyl+Ether+%28PBDE%29+and+Neonatal+Thyroid+Hormone+Levels&rft.au=Herbstman%2C+Julie+B%3BSjoedin%2C+Andreas%3BApelberg%2C+Benjamin+J%3BWitter%2C+Frank+R%3BHalden%2C+Rolf+U%3BPatterson%2C+Donald+G%3BPanny%2C+Susan+R%3BNeedham%2C+Larry+L%3BGoldman%2C+Lynn+R&rft.aulast=Herbstman&rft.aufirst=Julie&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1376&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Built Environment and Physical Functioning in Hispanic Elders: The Role of "Eyes on the Street" AN - 743095058; 201004-31-0304805 (CE); 12103999 (EN) AB - BACKGROUND: Research on neighborhood effects increasingly includes the influences of the built environment on health and social well-being. OBJECTIVES: In this population-based study in a low-socioeconomic-status (SES), Hispanic neighborhood, we examined whether architectural features of the built environment theorized to promote direct observations and interactions (e.g., porches, stoops) predicted Hispanic elders' social support and psychological and physical functioning. METHODS: We coded built-environment features for all 3,857 lots in the 403-block area of an urban Miami, Florida, community. We then conducted three annual assessments of social support, psychological distress, and physical functioning in a population-based sample of 273 low-SES Hispanic elders (70-100 years of age). We used structural equation modeling analytic techniques to examine hypothesized relationships between the built environment and elders' social support, psychological distress, and physical functioning over a 3-year period. RESULTS: After controlling for age, sex, and income, architectural features of the built environment theorized to facilitate visual and social contact had a significant direct relationship with elders' physical functioning as measured 3 years later, and an indirect relationship through social support and psychological distress. Further binomial regression analyses suggested that elders living on blocks marked by low levels of positive front entrance features were 2.7 times as likely to have subsequent poor levels of physical functioning, compared with elders living on blocks with a greater number of positive front entrance features [b = 0.99; chi(2) (1 df) = 3.71; p = 0.05; 95% confidence interval, 1.0-7.3]. CONCLUSIONS: Architectural features that facilitate visual and social contacts may be a protective factor for elders' physical functioning. JF - Environmental Health Perspectives AU - Brown, Scott C AU - Mason, Craig A AU - Perrino, Tatiana AU - Lombard, Joanna L AU - Martinez, Frank AU - Plater-Zyberk, Elizabeth AU - Spokane, Arnold R AU - Szapocznik, Jose PY - 2008 SP - 1300 EP - 1307 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Architecture KW - Health KW - Contact KW - Mathematical analysis KW - Entrances KW - Visual KW - Age KW - Assessments KW - Protective KW - Regression analysis KW - Low level KW - Confidence intervals KW - Communities KW - Binomials KW - Copyrights KW - Income KW - Sex KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743095058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Built+Environment+and+Physical+Functioning+in+Hispanic+Elders%3A+The+Role+of+%22Eyes+on+the+Street%22&rft.au=Brown%2C+Scott+C%3BMason%2C+Craig+A%3BPerrino%2C+Tatiana%3BLombard%2C+Joanna+L%3BMartinez%2C+Frank%3BPlater-Zyberk%2C+Elizabeth%3BSpokane%2C+Arnold+R%3BSzapocznik%2C+Jose&rft.aulast=Brown&rft.aufirst=Scott&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1300&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Prenatal Exposure to Perfluorooctanoate (PFOA) and Perfluorooctanesulfonate (PFOS) and Maternally Reported Developmental Milestones in Infancy AN - 743072888; 201004-31-0304791 (CE); 12103985 (EN) AB - BACKGROUND: Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are fluorinated organic compounds present in the general population at low concentrations. Animal studies have shown that they may affect neuromuscular development at high concentrations. OBJECTIVES: We investigated the association between plasma levels of PFOS and PFOA in pregnant women and motor and mental developmental milestones of their children. METHODS: We randomly selected 1,400 pairs of pregnant women and their children from the Danish National Birth Cohort. PFOS and PFOA were measured in maternal blood samples taken in early pregnancy. Apgar score was abstracted from the National Hospital Discharge Register in Denmark. Developmental milestones were reported by mothers using highly structured questionnaires when the children were around 6 months and 18 months of age. RESULTS: Mothers who had higher levels of PFOA and PFOS gave birth to children who had similar Apgar scores and reached virtually all of the development milestones at the same time as children born to mothers with lower exposure levels. Children who were born to mothers with higher PFOS levels were slightly more likely to start sitting without support at a later age. CONCLUSION: We found no convincing associations between developmental milestones in early childhood and levels of PFOA or PFOS as measured in maternal plasma early in pregnancy. JF - Environmental Health Perspectives AU - Fei, Chunyuan AU - McLaughlin, Joseph K AU - Lipworth, Loren AU - Olsen, Joern PY - 2008 SP - 1391 EP - 1395 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Health KW - Birth KW - Age KW - Pregnancy KW - Hospitals KW - Copyrights KW - Blood KW - Motors KW - Registers KW - Discharge KW - Organic compounds KW - Fluorination KW - Animals KW - Low concentrations KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743072888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prenatal+Exposure+to+Perfluorooctanoate+%28PFOA%29+and+Perfluorooctanesulfonate+%28PFOS%29+and+Maternally+Reported+Developmental+Milestones+in+Infancy&rft.au=Fei%2C+Chunyuan%3BMcLaughlin%2C+Joseph+K%3BLipworth%2C+Loren%3BOlsen%2C+Joern&rft.aulast=Fei&rft.aufirst=Chunyuan&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1391&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Review of usnic acid and Usnea barbata toxicity. AN - 69831200; 19034791 AB - Usnic acid is a prominent secondary lichen metabolite that has been used for various purposes worldwide. Crude extracts of usnic acid or pure usnic acid have been marketed in the United States as dietary supplements to aid in weight loss. The US Food and Drug Administration (FDA) received 21 reports of liver toxicity related to the ingestion of dietary supplements that contain usnic acid. This prompted the FDA to issue a warning about one such supplement, LipoKinetix, in 2001 (http://www.cfsan.fda.gov/~dms/ds-lipo.html). Subsequently, usnic acid and Usnea barbata lichen were nominated by the National Toxicology Program (NTP) for toxicity evaluations. At present, a toxicological evaluation of usnic acid is being conducted by the NTP. This review focuses on the recent findings of usnic acid-induced toxicities and their underlying mechanisms of action. JF - Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews AU - Guo, Lei AU - Shi, Qiang AU - Fang, Jia-Long AU - Mei, Nan AU - Ali, A Afshan AU - Lewis, Sherry M AU - Leakey, Julian E A AU - Frankos, Vasilios H AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. lei.guo@fda.hhs.gov PY - 2008 SP - 317 EP - 338 VL - 26 IS - 4 KW - Benzofurans KW - 0 KW - Plant Extracts KW - usnic acid KW - 0W584PFJ77 KW - Index Medicus KW - Animals KW - Mutagenicity Tests KW - Liver -- drug effects KW - Humans KW - Weight Loss KW - Plant Extracts -- pharmacology KW - Benzofurans -- pharmacokinetics KW - Plant Extracts -- toxicity KW - Plant Extracts -- pharmacokinetics KW - Usnea -- chemistry KW - Benzofurans -- toxicity KW - Benzofurans -- pharmacology KW - Benzofurans -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69831200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.atitle=Review+of+usnic+acid+and+Usnea+barbata+toxicity.&rft.au=Guo%2C+Lei%3BShi%2C+Qiang%3BFang%2C+Jia-Long%3BMei%2C+Nan%3BAli%2C+A+Afshan%3BLewis%2C+Sherry+M%3BLeakey%2C+Julian+E+A%3BFrankos%2C+Vasilios+H&rft.aulast=Guo&rft.aufirst=Lei&rft.date=2008-10-01&rft.volume=26&rft.issue=4&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.issn=1532-4095&rft_id=info:doi/10.1080%2F10590500802533392 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-29 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10590500802533392 ER - TY - JOUR T1 - Brain region-specific neurodegenerative profiles showing the relative importance of amphetamine dose, hyperthermia, seizures, and the blood-brain barrier. AN - 69764921; 18991857 AB - Understanding the neurotoxic effects of acute high-dose exposures of laboratory animals to methamphetamine (METH) and amphetamine (AMPH) is of relevance to understanding the neurotoxicity incurred in humans from overdose or abuse of these substances. We present recent findings on the neurodegenerative effects of both a single high dose of 40 mg/kg and a 4-dose exposure to AMPH in the rat. Comparing these results with those we have previously observed in rodents exposed to either AMPH or METH helps further address how dose, hyperthermia, seizures and blood-brain barrier (BBB) disruption interact to produce neurodegeneration. With regard to the 4-dose paradigm of AMPH exposure in the rat, our recent data, combined with previous findings, clearly show the importance of dose and hyperthermic interactions in producing neurodegeneration. The single high AMPH dose invariably resulted in extreme hyperthermia and brief episodes of clonic-tonic seizure activity in many rats. However, motor behavior indicative of status epilepticus was not observed in rats receiving the 40 mg/kg AMPH, which contrasts with what we have previously seen with 40 mg/kg METH dose in the mouse. This may explain why, unlike the mice given METH, there was minimal BBB disruption in the amygdala of rats. Nonetheless, in some of the surviving rats there was extensive neurodegeneration in the hippocampus and intralaminar and ventromedial/lateral thalamic nuclei. Early BBB disruption was seen in the hippocampus and may play an important role in the subsequent neurodegeneration. The fact that status epilepticus does not occur in rats that have major hippocampal and thalamic degeneration indicates that such damage may also occur in humans exposed to high doses of AMPH or METH in the absence of status epilepticus or prominent motor manifestations of seizure activity. JF - Annals of the New York Academy of Sciences AU - Bowyer, John F AU - Thomas, Monzy AU - Schmued, Larry C AU - Ali, Syed F AD - Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA. john.bowyer@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 127 EP - 139 VL - 1139 KW - Central Nervous System Stimulants KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Humans KW - Mice KW - Male KW - Hippocampus -- drug effects KW - Hippocampus -- anatomy & histology KW - Seizures -- chemically induced KW - Fever -- chemically induced KW - Blood-Brain Barrier -- drug effects KW - Central Nervous System Stimulants -- pharmacology KW - Nerve Degeneration -- pathology KW - Nerve Degeneration -- chemically induced KW - Blood-Brain Barrier -- pathology KW - Amphetamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69764921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Brain+region-specific+neurodegenerative+profiles+showing+the+relative+importance+of+amphetamine+dose%2C+hyperthermia%2C+seizures%2C+and+the+blood-brain+barrier.&rft.au=Bowyer%2C+John+F%3BThomas%2C+Monzy%3BSchmued%2C+Larry+C%3BAli%2C+Syed+F&rft.aulast=Bowyer&rft.aufirst=John&rft.date=2008-10-01&rft.volume=1139&rft.issue=&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1432.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-09 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1432.005 ER - TY - JOUR T1 - Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury. AN - 69763314; 18991870 AB - The psychostimulant 3,4-,ethylenedioxymethamphetamine (MDMA, "ecstasy") is known to induce hyperthermia and alterations in neurochemical metabolism in the CNS. However, the detailed cellular or molecular mechanisms behind MDMA-induced neurotoxicity are still not well known. Since MDMA induces profound hyperthermia that could lead to intense cellular stress and cause disruption of the blood-brain barrier (BBB), this investigation examined the effects of acute MDMA on BBB dysfunction, brain edema, and cell injury in rats and mice. When MDMA (40 mg/kg, i.p.) was administered to rats or mice, these animals exhibited profound behavioral disturbances (hyperactivity and hyperlocomotion) and hyperthermia (>40 to 41 degrees C) at 4 h. At this time, the leakage of Evans blue dye was evident, particularly in the cerebellum, hippocampus, cortex, thalamus, and hypothalamus. This effect was most pronounced in mice compared to rats. Marked increase in brain water along with Na(+), K(+), and Cl(-) content was also seen in the aforementioned brain regions. Presence of distorted neuronal and glial cells in brain regions associated with leakage of Evans blue is quite common in MDMA-treated animals. Increased albumin immunoreactivity, indicating breakdown of the BBB, and upregulation of glial fibrillary acidic protein (GFAP), suggesting activation of astrocytes, were seen in most brain regions showing edematous changes. Upregulation of heat-shock protein (HSP72) immunoreactivity in the nuclei and cell cytoplasm of the neurons located in the edematous brain regions are quite common. Taken together, these observations are the first to show that MDMA has the capacity to disrupt BBB permeability to proteins and to induce the formation of edema, probably by inducing hyperthermia and cellular stress, as evident with HSP overexpression leading to cell injury. JF - Annals of the New York Academy of Sciences AU - Sharma, Hari Shanker AU - Ali, Syed F AD - Laboratory of Neurochemistry, Division of Neurotoxicology, National Center of Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. Sharma@surgsci.uu.se Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 242 EP - 258 VL - 1139 KW - Albumins KW - 0 KW - Coloring Agents KW - Hallucinogens KW - Heat-Shock Proteins KW - Evans Blue KW - 45PG892GO1 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Albumins -- metabolism KW - Heat-Shock Proteins -- metabolism KW - Animals KW - Astrocytes -- cytology KW - Evans Blue -- metabolism KW - Body Temperature -- drug effects KW - Coloring Agents -- metabolism KW - Mice KW - Rats KW - Behavior, Animal -- drug effects KW - Rats, Wistar KW - Mice, Inbred C57BL KW - Male KW - Astrocytes -- metabolism KW - Fever -- chemically induced KW - Blood-Brain Barrier -- drug effects KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Brain Edema -- chemically induced KW - Neurons -- cytology KW - Hallucinogens -- pharmacology KW - Blood-Brain Barrier -- pathology KW - N-Methyl-3,4-methylenedioxyamphetamine -- pharmacology KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69763314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Acute+administration+of+3%2C4-methylenedioxymethamphetamine+induces+profound+hyperthermia%2C+blood-brain+barrier+disruption%2C+brain+edema+formation%2C+and+cell+injury.&rft.au=Sharma%2C+Hari+Shanker%3BAli%2C+Syed+F&rft.aulast=Sharma&rft.aufirst=Hari&rft.date=2008-10-01&rft.volume=1139&rft.issue=&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1432.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-09 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1432.052 ER - TY - JOUR T1 - Transcriptional correlates of human substance use. AN - 69762402; 18991846 AB - Drugs of abuse produce both acute and chronic changes in brain function, each of which is reflected in altered gene expression patterns. A number of large-scale gene expression studies have employed microarray analysis of human postmortem brain to identify transcriptional correlates of antemortem substance use. These studies have identified changes in transcripts encoding proteins functionally involved in neuronal function and synaptic plasticity, oligodendrocyte function and myelination, lipid and energy metabolism, mitochondrial function, oxidative phosphorylation, and cytoskeleton-related signal transduction. Overall, different types of substance use appear to share some of these effects, but there are more differences than similarities in gene expression for different types of substance use. Moreover, data suggest that transcriptional subtypes within a diagnostic classification of substance use may occur. These transcriptional subtypes, or "endophenotypes," may reflect complex patterns of substance use and co-morbid neuropsychiatric disorders or other diseases, which may interact with substance use to differentially affect gene expression. A broader understanding of the manner in which substance abuse causes long-term changes in brain function may be obtained from studies replicating and expanding the present gene expression data. In particular, cross-referencing comprehensive transcriptional data on regional and/or substance use-specific changes with genetic and proteomic data may further aid in identifying candidate biomarkers of altered brain function in substance-use disorders. JF - Annals of the New York Academy of Sciences AU - Lehrmann, Elin AU - Freed, William J AD - Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 34 EP - 42 VL - 1139 KW - Index Medicus KW - Gene Expression Profiling KW - Autopsy KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Brain -- anatomy & histology KW - Cluster Analysis KW - Brain -- physiology KW - Substance-Related Disorders -- physiopathology KW - Substance-Related Disorders -- diagnosis KW - Transcription, Genetic KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69762402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Transcriptional+correlates+of+human+substance+use.&rft.au=Lehrmann%2C+Elin%3BFreed%2C+William+J&rft.aulast=Lehrmann&rft.aufirst=Elin&rft.date=2008-10-01&rft.volume=1139&rft.issue=&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1432.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-09 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurobiol Dis. 2005 Apr;18(3):649-55 [15755690] Biol Psychiatry. 2005 Jan 1;57(1):96-101 [15607306] Am J Psychiatry. 2005 Aug;162(8):1403-13 [16055761] Brain Res Mol Brain Res. 2005 Oct 3;139(2):317-32 [16122832] Neuroimage. 2005 Dec;28(4):904-14 [16061398] Neuropsychopharmacology. 2006 Mar;31(3):644-50 [16123763] J Nerv Ment Dis. 2006 Mar;194(3):164-72 [16534433] Neuropsychopharmacology. 2006 Apr;31(4):768-77 [16160706] J Clin Psychiatry. 2006 Feb;67(2):247-57 [16566620] Neuropsychopharmacology. 2006 Jul;31(7):1574-82 [16292326] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4680-5 [11930015] J Neurochem. 2002 May;81(4):802-13 [12065639] Pharmacogenomics J. 2003;3(1):27-40 [12629581] J Neurochem. 2003 May;85(3):543-62 [12694381] Drug Alcohol Depend. 2003 May 21;70(2):117-25 [12732403] J Neurosci Res. 2003 Jun 15;72(6):756-67 [12774316] Eur J Neurosci. 2003 May;17(10):2212-8 [12786988] Curr Mol Med. 2003 Aug;3(5):437-46 [12942997] BMC Bioinformatics. 2003 Sep 8;4:37 [12962547] Brain Res Bull. 2006 Jul 31;70(3):251-9 [16861111] Neuropsychopharmacology. 2006 Oct;31(10):2304-12 [16710320] Biol Psychiatry. 2006 Sep 15;60(6):650-8 [16997002] Brain Res. 2006 Dec 6;1123(1):1-11 [17045977] PLoS One. 2006;1:e114 [17205118] Int J Neuropsychopharmacol. 2007 Aug;10(4):557-63 [17291371] Int J Neuropsychopharmacol. 2007 Aug;10(4):547-55 [17291372] Alcohol Clin Exp Res. 2007 Sep;31(9):1460-6 [17625000] Addict Biol. 2008 Mar;13(1):105-17 [18201295] Mol Psychiatry. 2006 Jul;11(7):615, 663-79 [16636682] Alcohol Clin Exp Res. 2000 Dec;24(12):1873-82 [11141048] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4746-51 [11296301] Neuropsychopharmacology. 2004 Feb;29(2):373-84 [14583743] Biol Psychiatry. 2004 Feb 15;55(4):346-52 [14960286] J Neurochem. 2004 Mar;88(5):1211-9 [15009677] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] J Neurochem. 2004 Sep;90(5):1050-8 [15312160] J Neurosci Res. 2004 Sep 15;77(6):858-66 [15334603] Biol Psychiatry. 1993 Mar 15;33(6):456-66 [8098224] J Neurochem. 1993 Jul;61(1):1-11 [7685811] Am J Psychiatry. 1996 Apr;153(4):533-7 [8599402] Neuron. 1997 Sep;19(3):591-611 [9331351] J Neurochem. 2005 Apr;93(2):359-70 [15816859] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1432.027 ER - TY - JOUR T1 - Histopathology of vascular injury in Sprague-Dawley rats treated with phosphodiesterase IV inhibitor SCH 351591 or SCH 534385. AN - 69717086; 18776163 AB - Histopathological and immunohistochemical studies were conducted to characterize vascular injuries in rats treated with phosphodiesterase (PDE) IV inhibitors SCH 351591 or SCH 534385. Sprague-Dawley rats were administered PDE IV inhibitors by gavage at a range of doses and times. The two PDE IV inhibitors induced comparable levels of vascular injury, primarily in the mesentery and to a lesser extent in the pancreas, kidney, liver, small intestine, and stomach. Mesenteric vascular changes occurred as early as one hour, progressively developed over twenty-four to forty-eight hours, peaked at seventy-two hours, and gradually subsided from seven to nine days. The typical morphology of the vascular toxicity consisted of hemorrhage and necrosis of arterioles and arteries, microvascular injury, fibrin deposition, and perivascular inflammation of a variety of blood vessels. The incidence and severity of mesenteric vascular injury increased in a time- and dose-dependent manner in SCH 351591- or SCH 534385-treated rats. Mesenteric vascular injury was frequently associated with activation of mast cells (MC), endothelial cells (EC), and macrophages (MØ). Immunohistochemical studies showed increases in CD63 immunoreactivity of mesenteric MC and in nitrotyrosine immunoreactivity of mesenteric EC and MØ. The present study also provides a morphological and cellular basis for evaluating candidate biomarkers of drug-induced vascular injury. JF - Toxicologic pathology AU - Zhang, Jun AU - Snyder, Ronald D AU - Herman, Eugene H AU - Knapton, Alan AU - Honchel, Ronald AU - Miller, Terry AU - Espandiari, Parvaneh AU - Goodsaid, Federico M AU - Rosenblum, Irwin Y AU - Hanig, Joseph P AU - Sistare, Frank D AU - Weaver, James L AD - Division of Applied Pharmacology Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. jun.zhang@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 827 EP - 839 VL - 36 IS - 6 KW - Cyclic N-Oxides KW - 0 KW - Phosphodiesterase 4 Inhibitors KW - Phosphodiesterase Inhibitors KW - Quinolines KW - SCH 351591 KW - Index Medicus KW - Pancreas -- pathology KW - Animals KW - Intestine, Small -- blood supply KW - Stomach -- blood supply KW - Kidney -- pathology KW - Mesenteric Arteries -- pathology KW - Rats KW - Stomach -- pathology KW - Rats, Sprague-Dawley KW - Pancreas -- blood supply KW - Kidney -- blood supply KW - Intestine, Small -- pathology KW - Immunohistochemistry KW - Statistics, Nonparametric KW - Quinolines -- toxicity KW - Vascular Diseases -- pathology KW - Vascular Diseases -- chemically induced KW - Phosphodiesterase Inhibitors -- toxicity KW - Cyclic N-Oxides -- toxicity KW - Blood Vessels -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69717086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Histopathology+of+vascular+injury+in+Sprague-Dawley+rats+treated+with+phosphodiesterase+IV+inhibitor+SCH+351591+or+SCH+534385.&rft.au=Zhang%2C+Jun%3BSnyder%2C+Ronald+D%3BHerman%2C+Eugene+H%3BKnapton%2C+Alan%3BHonchel%2C+Ronald%3BMiller%2C+Terry%3BEspandiari%2C+Parvaneh%3BGoodsaid%2C+Federico+M%3BRosenblum%2C+Irwin+Y%3BHanig%2C+Joseph+P%3BSistare%2C+Frank+D%3BWeaver%2C+James+L&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2008-10-01&rft.volume=36&rft.issue=6&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308322308 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-11 N1 - Date created - 2008-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623308322308 ER - TY - JOUR T1 - Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385. AN - 69713474; 18776166 AB - Drug-associated vascular injury can be caused by phosphodiesterase (PDE) IV inhibitors and drugs from several other classes. The pathogenesis is poorly understood, but it appears to include vascular and innate immunological components. This research was undertaken to identify changes in peripheral blood associated with vascular injury caused by PDE IV inhibitors. We evaluated twelve proteins, serum nitrite, and leukocyte populations in peripheral blood of rats treated with experimental PDE IV inhibitors. We found that these compounds produced histological microvascular injury in a dose- and time-dependent manner. Measurement of these serum proteins showed changes in eight of the twelve examined. Changes were seen in the levels of: tissue inhibitor of metalloproteinase-1, alpha1-acid glycoprotein, GRO/CINC-1, vascular endothelial growth factor, C-reactive protein, haptoglobin, thrombomodulin, and interleukin-6. No changes were seen in levels of tumor necrosis factor-alpha, hepatocyte growth factor, nerve growth factor, and granulocyte-monocyte colony stimulating factor. Serum levels of nitrite were also increased. Circulating granulocyte numbers were increased, and lymphocyte numbers were decreased. The changes in these parameters showed both a dose- and time-dependent association with histopathologic changes. These biomarkers could provide an additional tool for the nonclinical and clinical evaluation of investigational compounds. JF - Toxicologic pathology AU - Weaver, James L AU - Snyder, Ronald AU - Knapton, Alan AU - Herman, Eugene H AU - Honchel, Ronald AU - Miller, Terry AU - Espandiari, Parvaneh AU - Smith, Roger AU - Gu, Yi-Zhong AU - Goodsaid, Federico M AU - Rosenblum, Irwin Y AU - Sistare, Frank D AU - Zhang, Jun AU - Hanig, Joseph AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. james.weaver@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 840 EP - 849 VL - 36 IS - 6 KW - Biomarkers KW - 0 KW - Cyclic N-Oxides KW - Nitrates KW - Nitrites KW - Phosphodiesterase 4 Inhibitors KW - Phosphodiesterase Inhibitors KW - Quinolines KW - SCH 351591 KW - Index Medicus KW - Rats KW - Nitrites -- blood KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Clinical Chemistry Tests KW - Mesenteric Arteries -- pathology KW - Immunohistochemistry KW - Leukocyte Count KW - Nitrates -- blood KW - Quinolines -- toxicity KW - Vascular Diseases -- pathology KW - Vascular Diseases -- chemically induced KW - Vascular Diseases -- blood KW - Phosphodiesterase Inhibitors -- toxicity KW - Cyclic N-Oxides -- toxicity KW - Blood Vessels -- drug effects KW - Biomarkers -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69713474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Biomarkers+in+peripheral+blood+associated+with+vascular+injury+in+Sprague-Dawley+rats+treated+with+the+phosphodiesterase+IV+inhibitors+SCH+351591+or+SCH+534385.&rft.au=Weaver%2C+James+L%3BSnyder%2C+Ronald%3BKnapton%2C+Alan%3BHerman%2C+Eugene+H%3BHonchel%2C+Ronald%3BMiller%2C+Terry%3BEspandiari%2C+Parvaneh%3BSmith%2C+Roger%3BGu%2C+Yi-Zhong%3BGoodsaid%2C+Federico+M%3BRosenblum%2C+Irwin+Y%3BSistare%2C+Frank+D%3BZhang%2C+Jun%3BHanig%2C+Joseph&rft.aulast=Weaver&rft.aufirst=James&rft.date=2008-10-01&rft.volume=36&rft.issue=6&rft.spage=840&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308322310 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-11 N1 - Date created - 2008-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623308322310 ER - TY - JOUR T1 - FDA drug approval summary: lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2. AN - 69711997; 18849320 AB - On March 13, 2007, the U.S. Food and Drug Administration approved lapatinib (Tykerb tablets; GlaxoSmithKline, Philadelphia), an oral, small molecule, dual tyrosine kinase inhibitor of ErbB-2 and ErbB-1, for use in combination with capecitabine for the treatment of patients with human epidermal growth factor receptor (HER)-2-overexpressing metastatic breast cancer who had received prior therapy including an anthracycline, a taxane, and trastuzumab. One multicenter, open-label, randomized trial was submitted. Eligible patients had stage IIIb or IV breast cancer, ErbB-2 overexpression (immunohistochemistry 3+ or 2+ with fluorescence in situ hybridization confirmation), measurable disease, a 0 or 1 Eastern Cooperative Oncology Group performance status score, a cardiac ejection fraction within the institutional normal range, and adequate laboratory function. Patients received either lapatinib (1,250 mg once daily on days 1-21) plus capecitabine (1,000 mg/m(2) every 12 hours on days 1-14) every 21 days or capecitabine alone (1,250 mg/m(2) every 12 hours on days 1-14) every 21 days. The primary endpoint was time to progression (TTP) determined by a blinded independent review panel. After TTP results of a prespecified interim analysis were made available, study enrollment was discontinued (399 patients enrolled). The median TTP was 27.1 versus 18.6 weeks (hazard ratio, 0.57; p = .00013) favoring the lapatinib plus capecitabine arm. Response rates were 23.7% (lapatinib plus capecitabine) versus 13.9% (capecitabine alone). Survival data were not mature. Although the toxicities observed in the lapatinib and capecitabine combination arm were generally similar to those in the capecitabine alone arm, a higher incidence of diarrhea and rash was noted with the combination. Grade 3 or 4 adverse reactions that occurred with a frequency of >5% in patients on the combination arm were diarrhea (13%) and palmar-plantar erythrodysesthesia (12%). There was a 2% incidence of reversible decreased left ventricular function in the combination arm. JF - The oncologist AU - Ryan, Qin AU - Ibrahim, Amna AU - Cohen, Martin H AU - Johnson, John AU - Ko, Chia-wen AU - Sridhara, Rajeshwari AU - Justice, Robert AU - Pazdur, Richard AD - Division of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. qin.ryan@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1114 EP - 1119 VL - 13 IS - 10 KW - Quinazolines KW - 0 KW - lapatinib KW - 0VUA21238F KW - Deoxycytidine KW - 0W860991D6 KW - Capecitabine KW - 6804DJ8Z9U KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - United States KW - Young Adult KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Disease Progression KW - Aged KW - Drug Resistance, Neoplasm KW - Quinazolines -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- adverse effects KW - United States Food and Drug Administration KW - Deoxycytidine -- adverse effects KW - Aged, 80 and over KW - Drug Approval KW - Fluorouracil -- analogs & derivatives KW - Adult KW - Neoplasm Metastasis KW - Deoxycytidine -- administration & dosage KW - Middle Aged KW - Quinazolines -- adverse effects KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Receptor, ErbB-2 -- antagonists & inhibitors KW - Breast Neoplasms -- enzymology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Receptor, ErbB-2 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69711997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+drug+approval+summary%3A+lapatinib+in+combination+with+capecitabine+for+previously+treated+metastatic+breast+cancer+that+overexpresses+HER-2.&rft.au=Ryan%2C+Qin%3BIbrahim%2C+Amna%3BCohen%2C+Martin+H%3BJohnson%2C+John%3BKo%2C+Chia-wen%3BSridhara%2C+Rajeshwari%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Ryan&rft.aufirst=Qin&rft.date=2008-10-01&rft.volume=13&rft.issue=10&rft.spage=1114&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2008-0816 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-25 N1 - Date created - 2008-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2008-0816 ER - TY - JOUR T1 - Lenalidomide in combination with dexamethasone for the treatment of multiple myeloma after one prior therapy. AN - 69708087; 18922829 AB - Lenalidomide (CC-5013, Revlimid; Celgene Corporation, Summit, NJ), a thalidomide analogue, was granted approval by the U.S. Food and Drug Administration (FDA) on June 29, 2006, for use in combination with dexamethasone in patients with multiple myeloma (MM) who have received at least one prior therapy. The FDA approved lenalidomide with a restricted distribution program, RevAssist. In two randomized, double-blind, multicenter studies, the combination of lenalidomide and dexamethasone (LD) was compared with placebo and dexamethasone (PD) in patients with MM who had received at least one prior therapy. The primary endpoint was time to progression (TTP). Following a prespecified interim analysis of TTP, an independent data-monitoring committee advised the sponsor to halt the two studies. For both studies, the interim analysis for efficacy revealed a statistically significant longer TTP with LD than with PD. The most clinically relevant grade 3 and 4 adverse events that occurred more frequently in the LD arm were neutropenia, thrombocytopenia, deep vein thrombosis, pulmonary embolism, and atrial fibrillation. Thrombotic or thromboembolic events, including deep vein thrombosis, pulmonary embolism, thrombosis, and intracranial venous sinus thrombosis were reported more frequently in patients treated with LD than with PD. The FDA approved lenalidomide based on interim results from two multicenter, placebo-controlled, randomized trials comparing the combination of LD with PD that revealed a longer TTP with LD than with PD. The major toxicity observed during these trials was myelosuppression. The serious toxicities included thromboembolic events. Lenalidomide is only available under the RevAssist Program. JF - The oncologist AU - Hazarika, Maitreyee AU - Rock, Edwin AU - Williams, Gene AU - Dagher, Ramzi AU - Sridhara, Rajeshwari AU - Booth, Brian AU - Farrell, Ann AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1120 EP - 1127 VL - 13 IS - 10 KW - Placebos KW - 0 KW - Thalidomide KW - 4Z8R6ORS6L KW - Dexamethasone KW - 7S5I7G3JQL KW - lenalidomide KW - F0P408N6V4 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Thalidomide -- adverse effects KW - Double-Blind Method KW - Aged, 80 and over KW - Humans KW - Drug Approval KW - Disease Progression KW - Aged KW - Thalidomide -- administration & dosage KW - Middle Aged KW - Male KW - Female KW - Thalidomide -- analogs & derivatives KW - Dexamethasone -- therapeutic use KW - Dexamethasone -- adverse effects KW - Multiple Myeloma -- drug therapy KW - Dexamethasone -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69708087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Lenalidomide+in+combination+with+dexamethasone+for+the+treatment+of+multiple+myeloma+after+one+prior+therapy.&rft.au=Hazarika%2C+Maitreyee%3BRock%2C+Edwin%3BWilliams%2C+Gene%3BDagher%2C+Ramzi%3BSridhara%2C+Rajeshwari%3BBooth%2C+Brian%3BFarrell%2C+Ann%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Hazarika&rft.aufirst=Maitreyee&rft.date=2008-10-01&rft.volume=13&rft.issue=10&rft.spage=1120&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2008-0077 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-25 N1 - Date created - 2008-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2008-0077 ER - TY - JOUR T1 - Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study. AN - 69685576; 18774129 AB - Concern about potential health impacts of low-level exposures to organophosphorus (OP) pesticides, bisphenol A (BPA), and phthalates among the general population is increasing. We measured levels of six dialkyl phosphate (DAP) metabolites of OP pesticides, a chlorpyrifos-specific metabolite (3,5,6-trichloro-2-pyridinol, TCPy), BPA, and 14 phthalate metabolites in urine samples of 100 pregnant women from the Generation R study, the Netherlands. The unadjusted and creatinine-adjusted concentrations were reported, and compared to National Health and Nutrition Examination Survey and other studies. In general, these metabolites were detectable in the urine of the women from the Generation R study and compared with other groups, they had relatively high-level exposures to OP pesticides and several phthalates but similar exposure to BPA. The median concentrations of total dimethyl (DM) metabolites was 264.0 n mol/g creatinine (Cr) and of total DAP was 316.0 n mol/g Cr. The median concentration of mono-ethyl phthalate (MEP) was 222.0 microg/g Cr; the median concentrations of mono-isobutyl phthalate (MiBP) and mono-n-butyl phthalate (MnBP) were above 50 microg/g Cr. The median concentrations of the three secondary metabolites of di-2-ethylhexyl phthalate (DEHP) were greater than 20 microg/g Cr. The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation. JF - Environmental research AU - Ye, Xibiao AU - Pierik, Frank H AU - Hauser, Russ AU - Duty, Susan AU - Angerer, Jürgen AU - Park, Melissa M AU - Burdorf, Alex AU - Hofman, Albert AU - Jaddoe, Vincent W V AU - Mackenbach, Johan P AU - Steegers, Eric A P AU - Tiemeier, Henning AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3-05, PO Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 260 EP - 267 VL - 108 IS - 2 KW - Benzhydryl Compounds KW - 0 KW - Environmental Pollutants KW - Organophosphorus Compounds KW - Pesticides KW - Phenols KW - Phthalic Acids KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Cities KW - Humans KW - Gestational Age KW - Cohort Studies KW - Adult KW - Gas Chromatography-Mass Spectrometry KW - Tandem Mass Spectrometry KW - Netherlands KW - Adolescent KW - Female KW - Pregnancy KW - Pesticides -- metabolism KW - Organophosphorus Compounds -- urine KW - Environmental Pollutants -- metabolism KW - Organophosphorus Compounds -- metabolism KW - Phenols -- metabolism KW - Pesticides -- urine KW - Phthalic Acids -- metabolism KW - Environmental Pollutants -- urine KW - Phenols -- urine KW - Phthalic Acids -- urine KW - Maternal Exposure KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69685576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Urinary+metabolite+concentrations+of+organophosphorous+pesticides%2C+bisphenol+A%2C+and+phthalates+among+pregnant+women+in+Rotterdam%2C+the+Netherlands%3A+the+Generation+R+study.&rft.au=Ye%2C+Xibiao%3BPierik%2C+Frank+H%3BHauser%2C+Russ%3BDuty%2C+Susan%3BAngerer%2C+J%C3%BCrgen%3BPark%2C+Melissa+M%3BBurdorf%2C+Alex%3BHofman%2C+Albert%3BJaddoe%2C+Vincent+W+V%3BMackenbach%2C+Johan+P%3BSteegers%2C+Eric+A+P%3BTiemeier%2C+Henning%3BLongnecker%2C+Matthew+P&rft.aulast=Ye&rft.aufirst=Xibiao&rft.date=2008-10-01&rft.volume=108&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2008.07.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-12 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):269-80 [15664359] Int J Hyg Environ Health. 2004 Oct;207(5):409-17 [15575555] Environ Health Perspect. 2005 Aug;113(8):1056-61 [16079079] Clin Chim Acta. 2005 Nov;361(1-2):20-9 [16004980] Occup Environ Med. 2005 Nov;62(11):806-18 [16234408] Environ Health Perspect. 2005 Dec;113(12):1802-7 [16330368] Environ Health Perspect. 2006 Feb;114(2):260-3 [16451864] Int J Androl. 2006 Feb;29(1):134-9; discussion 181-5 [16466533] Int J Androl. 2006 Feb;29(1):155-65; discussion 181-5 [16466535] Environ Health Perspect. 2006 Jun;114(6):805-9 [16759976] Environ Health Perspect. 2006 Aug;114(8):1158-61 [16882519] Eur J Epidemiol. 2006;21(6):475-84 [16826450] Toxicology. 2006 Sep 21;226(2-3):79-89 [16860916] Environ Mol Mutagen. 2006 Oct;47(8):571-8 [16795089] Environ Health Perspect. 2006 Nov;114(11):1763-9 [17107865] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2006;24(2):225-55 [17114111] Int J Hyg Environ Health. 2007 Jan;210(1):21-33 [17182278] Pediatr Res. 2007 Feb;61(2):243-50 [17237730] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Mar 1;847(2):114-25 [17055785] Int J Hyg Environ Health. 2007 May;210(3-4):319-33 [17400024] Environ Health Perspect. 2007 May;115(5):792-8 [17520070] Am J Epidemiol. 2007 Jun 15;165(12):1397-404 [17406008] Reprod Toxicol. 2007 Aug-Sep;24(2):131-8 [17768031] Hum Reprod. 2007 Oct;22(10):2715-22 [17704099] Eur J Epidemiol. 2007;22(12):917-23 [18095172] J Chromatogr B Biomed Sci Appl. 2001 Aug 5;759(1):43-9 [11499628] J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Oct 5;778(1-2):5-29 [12376114] Reprod Toxicol. 2002 Sep-Oct;16(5):721-34 [12406498] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jan 25;784(1):169-82 [12504195] Environ Health Perspect. 2003 Jan;111(1):79-84 [12515682] Regul Toxicol Pharmacol. 2003 Jun;37(3):382-95 [12758218] Environ Health Perspect. 2003 Jul;111(9):1148-51 [12842765] Environ Res. 2003 Oct;93(2):177-85 [12963402] Environ Health Perspect. 2003 Nov;111(14):1719-22 [14594621] Environ Health Perspect. 2003 Dec;111(16):1939-46 [14644670] Environ Health Perspect. 2004 Feb;112(2):186-200 [14754573] Environ Health Perspect. 2004 Mar;112(3):331-8 [14998749] J Expo Anal Environ Epidemiol. 2004 May;14(3):249-59 [15141154] Clin Chim Acta. 1972 May;38(2):475-6 [5026368] Environ Health Perspect. 1982 Nov;45:11-7 [7140682] Kidney Int. 1989 Jul;36(1):108-13 [2811052] Am Ind Hyg Assoc J. 1993 Oct;54(10):615-27 [8237794] J Expo Anal Environ Epidemiol. 2005 Jul;15(4):297-309 [15367928] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.envres.2008.07.014 ER - TY - JOUR T1 - Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats. AN - 69682432; 18843197 AB - The members of the platelet-derived growth factor (PDGF) and the transforming growth factor-beta (TGFbeta) pathways are important in the induction of liver fibrosis and cirrhosis; however, their role in the subsequent progression to hepatocellular carcinoma (HCC) remains elusive. Our study provides new insights into mechanisms of dysregulation of PDGFs, TGFbeta and signal transducer and activator of transcription (STAT) pathways in the pathogenesis of methyl-deficient rodent liver carcinogenesis, a remarkably relevant model to the development of HCC in humans. We demonstrated a progressive increase in the Pdgfs and TGFbeta expression in preneoplastic tissue and liver tumors indicating their promotional role in carcinogenesis, particularly in progression of liver fibrosis and cirrhosis. However, activation of the STAT3 occurred only in fully developed HCC and was associated with downregulation of the Socs1 gene. The inhibition of the Socs1 expression in HCC was associated with an increase in histone H3 lysine 9, H3 lysine 27, and H4 lysine 20 trimethylation at the Socs1 promoter, but not with promoter methylation. The results of our study suggest the following model of events in hepatocarcinogenesis: during early stages, overexpression of the Socs1 effectively inhibits TGFbeta- and PDGF-induced STAT3 activation, whereas, during the advanced stages of hepatocarcinogenesis, the Socs1 downregulation resulted in loss of its ability to attenuate the signal from the upregulated TGFbeta and PDGFs leading to oncogenic STAT3 activation and malignant cell transformation. This model illustrates that the Socs1 acts as classic tumor suppressor by preventing activation of the STAT3 and downregulation of Socs1 and consequent activation of STAT3 may be a crucial events leading to formation of HCC. JF - Cell cycle (Georgetown, Tex.) AU - Bagnyukova, Tetyana V AU - Tryndyak, Volodymyr P AU - Muskhelishvili, Levan AU - Ross, Sharon A AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 3202 EP - 3210 VL - 7 IS - 20 KW - Platelet-Derived Growth Factor KW - 0 KW - STAT3 Transcription Factor KW - Socs1 protein, rat KW - Stat3 protein, rat KW - Suppressor of Cytokine Signaling 1 Protein KW - Suppressor of Cytokine Signaling Proteins KW - Transforming Growth Factor beta KW - Methionine KW - AE28F7PNPL KW - Receptors, Platelet-Derived Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Receptors, Platelet-Derived Growth Factor -- metabolism KW - Animals KW - Platelet-Derived Growth Factor -- metabolism KW - Liver -- pathology KW - Random Allocation KW - Humans KW - Liver -- metabolism KW - Platelet-Derived Growth Factor -- genetics KW - Receptors, Platelet-Derived Growth Factor -- genetics KW - Rats KW - Signal Transduction -- physiology KW - Rats, Inbred F344 KW - Promoter Regions, Genetic KW - Down-Regulation KW - Gene Expression Regulation KW - Diet KW - Transforming Growth Factor beta -- genetics KW - Transforming Growth Factor beta -- metabolism KW - Methylation KW - Male KW - Suppressor of Cytokine Signaling Proteins -- metabolism KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Methionine -- deficiency KW - STAT3 Transcription Factor -- genetics KW - Suppressor of Cytokine Signaling Proteins -- genetics KW - STAT3 Transcription Factor -- metabolism KW - Epigenesis, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69682432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=Epigenetic+downregulation+of+the+suppressor+of+cytokine+signaling+1+%28Socs1%29+gene+is+associated+with+the+STAT3+activation+and+development+of+hepatocellular+carcinoma+induced+by+methyl-deficiency+in+rats.&rft.au=Bagnyukova%2C+Tetyana+V%3BTryndyak%2C+Volodymyr+P%3BMuskhelishvili%2C+Levan%3BRoss%2C+Sharon+A%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Bagnyukova&rft.aufirst=Tetyana&rft.date=2008-10-01&rft.volume=7&rft.issue=20&rft.spage=3202&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-24 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat. AN - 69653742; 18626999 AB - The product of the phosphatidylinositol glycan complementation group A gene (Pig-A) is involved in the synthesis of glycosylphosphatidylinositol (GPI) anchors that link various protein markers to the surface of several types of mammalian cells, including hematopoietic cells. Previous observations indicate that Pig-A mutation results in the lack of GPI synthesis and the absence of GPI-anchored proteins on the cell surface. As a first step in designing a rapid assay for measuring Pig-A mutation in the rat, we developed flow cytometry (FCM) strategies for detecting GPI-negative cells in rat peripheral blood and spleen. Anti-CD59 was used to detect GPI-anchored proteins on red blood cells (RBCs), and anti-CD48 was used to detect GPI-anchored proteins on spleen T-cells. The spontaneous frequency of CD59-negative RBCs in five male F344 rats ranged from 1 x 10(-6) to 27 x 10(-6). In contrast, treatment of five rats with three doses of 40 mg/kg N-ethyl-N-nitrosourea (ENU) increased the frequency of CD59-negative RBCs to 183 x 10(-6) to 249 x 10(-6) at 2 weeks and to 329 x 10(-6) to 413 x 10(-6) at 4 weeks after dosing. In the same 4-week posttreatment rats, the frequency of CD48-negative T-cells was 11 x 10(-6) to 16 x 10(-6) in control rats and 194 x 10(-6) to 473 x 10(-6) in ENU-treated rats. The frequencies of GPI-deficient cells were similar for RBCs and spleen T-cells. These results indicate that FCM detection of GPI-linked markers may form the basis for a rapid in vivo mutation assay. Although RBCs may be useful for a minimally invasive assay, T-cells are a promising tissue for both detecting GPI-deficient cells and confirming that Pig-A gene mutation is the cause of the phenotype. Published 2008 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Miura, Daishiro AU - Dobrovolsky, Vasily N AU - Kasahara, Yoshinori AU - Katsuura, Yasuhiro AU - Heflich, Robert H AD - Division of Genetic and Reproductive Toxicology, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 614 EP - 621 VL - 49 IS - 8 KW - Antigens, CD KW - 0 KW - Antigens, CD59 KW - CD48 Antigen KW - Cd48 protein, rat KW - Glycosylphosphatidylinositols KW - Membrane Proteins KW - Mutagens KW - phosphatidylinositol glycan-class A protein KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Ethylnitrosourea -- toxicity KW - Mutagens -- toxicity KW - Male KW - Mutagenicity Tests KW - Spleen -- cytology KW - Membrane Proteins -- genetics KW - Antigens, CD59 -- blood KW - T-Lymphocytes -- immunology KW - Erythrocytes -- immunology KW - Antigens, CD -- immunology KW - Flow Cytometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69653742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Development+of+an+in+vivo+gene+mutation+assay+using+the+endogenous+Pig-A+gene%3A+I.+Flow+cytometric+detection+of+CD59-negative+peripheral+red+blood+cells+and+CD48-negative+spleen+T-cells+from+the+rat.&rft.au=Miura%2C+Daishiro%3BDobrovolsky%2C+Vasily+N%3BKasahara%2C+Yoshinori%3BKatsuura%2C+Yasuhiro%3BHeflich%2C+Robert+H&rft.aulast=Miura&rft.aufirst=Daishiro&rft.date=2008-10-01&rft.volume=49&rft.issue=8&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20414 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-28 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20414 ER - TY - JOUR T1 - Development of an in vivo gene mutation assay using the endogenous Pig-A gene: II. Selection of Pig-A mutant rat spleen T-cells with proaerolysin and sequencing Pig-A cDNA from the mutants. AN - 69653688; 18626996 AB - We previously reported that rat spleen T-cells and peripheral red blood cells that are deficient in glycosylphosphatidylinositol (GPI) synthesis [presumed mutants for the phosphatidylinositol glycan complementation group A gene (Pig-A)] could be detected by flow cytometry (FCM) as cells negative for GPI-linked markers (CD48 and CD59, respectively). To establish this procedure as a rapid in vivo gene mutation assay, we have examined the Pig-A gene of GPI-deficient rat spleen T-cells for DNA sequence alterations. Splenocytes were isolated from male F344 rats, primed with ionomycin and phorbol-12-myristate-13-acetate, and seeded at limiting-dilution into 96-well plates. To select for GPI-deficient T-cells, the cells were cultured for 10 days in a medium containing rat T-STIM and 2 nM proaerolysin (ProAER). The frequency of ProAER-resistant (ProAER(r)) spleen T-cells from control rats ranged from 1.3 x 10(-6) to 4.8 x 10(-6), while administration of three doses of 40 mg/kg N-ethyl-N-nitrosourea increased the frequency of ProAER(r) T-cells 100-fold at 4 weeks after dosing. FCM analysis of the cells in ProAER(r) clones revealed that they were CD48-negative, and thus presumably GPI-deficient. Sequencing of Pig-A cDNA from six ProAER(r) clones indicated that they all contained alterations in the Pig-A protein coding sequence; five had base pair substitutions and one had multiple exons deleted. These results indicate that GPI-deficient spleen T-cells are Pig-A gene mutants and support the use of FCM analysis of GPI-deficient cells as a rapid assay for measuring in vivo gene mutation. Published 2008 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Miura, Daishiro AU - Dobrovolsky, Vasily N AU - Mittelstaedt, Roberta A AU - Kasahara, Yoshinori AU - Katsuura, Yasuhiro AU - Heflich, Robert H AD - Division of Genetic and Reproductive Toxicology, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 622 EP - 630 VL - 49 IS - 8 KW - Bacterial Toxins KW - 0 KW - DNA Primers KW - DNA, Complementary KW - Membrane Proteins KW - Pore Forming Cytotoxic Proteins KW - phosphatidylinositol glycan-class A protein KW - proaerolysin KW - Index Medicus KW - Rats KW - Animals KW - Base Sequence KW - Cells, Cultured KW - Flow Cytometry KW - Reverse Transcriptase Polymerase Chain Reaction KW - Pore Forming Cytotoxic Proteins -- toxicity KW - DNA, Complementary -- genetics KW - Spleen -- cytology KW - Bacterial Toxins -- toxicity KW - T-Lymphocytes -- drug effects KW - Membrane Proteins -- genetics KW - Spleen -- drug effects KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69653688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Development+of+an+in+vivo+gene+mutation+assay+using+the+endogenous+Pig-A+gene%3A+II.+Selection+of+Pig-A+mutant+rat+spleen+T-cells+with+proaerolysin+and+sequencing+Pig-A+cDNA+from+the+mutants.&rft.au=Miura%2C+Daishiro%3BDobrovolsky%2C+Vasily+N%3BMittelstaedt%2C+Roberta+A%3BKasahara%2C+Yoshinori%3BKatsuura%2C+Yasuhiro%3BHeflich%2C+Robert+H&rft.aulast=Miura&rft.aufirst=Daishiro&rft.date=2008-10-01&rft.volume=49&rft.issue=8&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20413 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-28 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20413 ER - TY - JOUR T1 - Pharmacokinetics, dose-range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice. AN - 69652703; 18618596 AB - Methylphenidate hydrochloride (MPH) is one of the most frequently prescribed pediatric drugs for the treatment of attention deficit hyperactivity disorder. In a recent study, increased hepatic adenomas were observed in B6C3F1 mice treated with MPH in their diet. To evaluate the reactive metabolite, ritalinic acid (RA) of MPH and its mode of action in mice, we conducted extensive investigations on the pharmacokinetics (PK) and genotoxicity of the drug in B6C3F1 mice. For the PK study, male B6C3F1 mice were gavaged once with 3 mg/kg body weight (BW) of MPH and groups of mice were sacrificed at various time points (0.25-24 hr) for serum analysis of MPH and RA concentrations. Groups of male B6C3F1 mice were fed diets containing 0, 250, 500, 1,000, 2,000, or 4,000 ppm of MPH for 28 days to determine the appropriate doses for 24-week transgenic mutation studies. Also, the micronucleus frequencies (MN-RETs and MN-NCEs), and the lymphocyte Hprt mutants were determined in peripheral blood and splenic lymphocytes, respectively. Mice fed 4,000 ppm of MPH lost significant BW compared to control mice (P < 0.01). There was a significant increase in the average liver weights whereas kidneys, seminal vesicle, testes, thymus, and urinary bladder weights of mice fed higher doses of MPH were significantly lower than the control group (P < or = 0.05). There was no significant increase in either the Hprt mutant frequency or the micronucleus frequency in the treated animals. These results indicated that although MPH induced liver hypertrophy in mice, no genotoxicity was observed. Published 2008 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Manjanatha, Mugimane G AU - Shelton, Sharon D AU - Dobrovolsky, Vasily N AU - Shaddock, Joseph G AU - McGarrity, Lynda G AU - Doerge, Daniel R AU - Twaddle, Nathan W AU - Lin, Chien-Ju AU - Chen, James J AU - Mattison, Donald R AU - Morris, Suzanne M AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. mugimane.manjanatha@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 585 EP - 593 VL - 49 IS - 8 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - ritalinic acid KW - GT4165RS9H KW - Index Medicus KW - Spectrometry, Mass, Electrospray Ionization KW - Animals KW - Liver -- enzymology KW - Liver -- pathology KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - Dose-Response Relationship, Drug KW - Mice KW - Mutagenicity Tests KW - Liver -- drug effects KW - Body Weight -- drug effects KW - Chromatography, Liquid KW - Feeding Behavior -- drug effects KW - Male KW - Organ Size -- drug effects KW - Methylphenidate -- administration & dosage KW - Methylphenidate -- pharmacokinetics KW - Methylphenidate -- toxicity KW - Methylphenidate -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69652703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Pharmacokinetics%2C+dose-range%2C+and+mutagenicity+studies+of+methylphenidate+hydrochloride+in+B6C3F1+mice.&rft.au=Manjanatha%2C+Mugimane+G%3BShelton%2C+Sharon+D%3BDobrovolsky%2C+Vasily+N%3BShaddock%2C+Joseph+G%3BMcGarrity%2C+Lynda+G%3BDoerge%2C+Daniel+R%3BTwaddle%2C+Nathan+W%3BLin%2C+Chien-Ju%3BChen%2C+James+J%3BMattison%2C+Donald+R%3BMorris%2C+Suzanne+M&rft.aulast=Manjanatha&rft.aufirst=Mugimane&rft.date=2008-10-01&rft.volume=49&rft.issue=8&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20407 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-28 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20407 ER - TY - JOUR T1 - A framework for the concurrent consideration of occupational hazards and obesity. AN - 69642908; 18765399 AB - Occupational hazards and obesity can lead to extensive morbidity and mortality and put great financial burden on society. Historically, occupational hazards and obesity have been addressed as separate unrelated issues, but both are public health problems and there may be public health benefits from considering them together. This paper provides a framework for the concurrent consideration of occupational hazards and obesity. The framework consists of the following elements: (i) investigate the relationship between occupational hazards and obesity, (ii) explore the impact of occupational morbidity and mortality and obesity on workplace absence, disability, productivity and healthcare costs, (iii) assess the utility of the workplace as a venue for obesity prevention programs, (iv) promote a comprehensive approach to worker health and (v) identify and address the ethical, legal and social issues. Utilizing this framework may advance the efforts to address the major societal health problems of occupational hazards and obesity. JF - The Annals of occupational hygiene AU - Schulte, P A AU - Wagner, G R AU - Downes, A AU - Miller, D B AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-C14, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 555 EP - 566 VL - 52 IS - 7 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Health KW - Obesity -- prevention & control KW - Obesity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69642908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=A+framework+for+the+concurrent+consideration+of+occupational+hazards+and+obesity.&rft.au=Schulte%2C+P+A%3BWagner%2C+G+R%3BDownes%2C+A%3BMiller%2C+D+B&rft.aulast=Schulte&rft.aufirst=P&rft.date=2008-10-01&rft.volume=52&rft.issue=7&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmen055 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-22 N1 - Date created - 2008-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/men055 ER - TY - JOUR T1 - Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes. AN - 69624663; 18632753 AB - Aromatic amines (AAs) and polycyclic aromatic hydrocarbons (PAHs) are carcinogens present in tobacco smoke and functional polymorphisms in NAT2 and GSTM1 metabolizing genes are associated with increased bladder cancer risk. We evaluated whether genetic variation in other candidate metabolizing genes are also associated with risk. Candidates included genes that control the transcription of metabolizing genes [aryl hydrocarbon receptor (AHR), AHRR and aryl hydrocarbon nuclear translocator (ARNT)] and genes that activate/detoxify AA or PAH (AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX1, EPHX2, NQO1, MPO, UGT1A4, SULT1A1 and SULT1A2). Using genotype data from 1150 cases of urothelial carcinomas and 1149 controls from the Spanish Bladder Cancer Study, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) adjusting for age, gender, region and smoking status. Based on a test for trend, we observed 10 non-redundant single-nucleotide polymorphisms (SNPs) in five genes (AKR1C3, ARNT, CYP1A1, CYP1B1 and SULT1A2) significantly associated with bladder cancer risk. We observed an inverse association with risk for the AKR1C3 promoter SNP rs1937845 [OR (95% CI) for heterozygote and homozygote variant compared with common homozygote genotype were 0.86 (0.70-1.06) and 0.74 (0.57-0.96), respectively; P for trend = 0.02]. Interestingly, genetic variation in this region has been associated with lung, non-Hodgkin lymphoma and prostate cancer risk. Analysis of additional SNPs to capture most (approximately 90%) of common genetic variation in AKR1C3 and haplotype walking analyses based on all AKR1C3 SNPs (n = 25) suggest two separate regions associated with bladder cancer risk. These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk. JF - Carcinogenesis AU - Figueroa, Jonine D AU - Malats, Núria AU - García-Closas, Montserrat AU - Real, Francisco X AU - Silverman, Debra AU - Kogevinas, Manolis AU - Chanock, Stephen AU - Welch, Robert AU - Dosemeci, Mustafa AU - Lan, Qing AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Castaño-Vinyals, Gemma AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. figueroaj@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1955 EP - 1962 VL - 29 IS - 10 KW - ARNT protein, human KW - 0 KW - Aryl Hydrocarbon Receptor Nuclear Translocator KW - 138391-32-9 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - 3-Hydroxysteroid Dehydrogenases KW - EC 1.1.- KW - AKR1C3 protein, human KW - EC 1.1.1.- KW - Hydroxyprostaglandin Dehydrogenases KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1B1 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Genetic Variation KW - Cytochrome P-450 CYP1A1 -- genetics KW - Cytochrome P-450 Enzyme System -- genetics KW - Humans KW - Aged KW - Glutathione Transferase -- genetics KW - Genotype KW - Promoter Regions, Genetic KW - Haplotypes KW - Aged, 80 and over KW - Aryl Hydrocarbon Receptor Nuclear Translocator -- genetics KW - Risk Factors KW - Adult KW - Middle Aged KW - Male KW - Female KW - Polymorphism, Single Nucleotide KW - Urinary Bladder Neoplasms -- etiology KW - 3-Hydroxysteroid Dehydrogenases -- genetics KW - Hydroxyprostaglandin Dehydrogenases -- genetics KW - Urinary Bladder Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69624663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Bladder+cancer+risk+and+genetic+variation+in+AKR1C3+and+other+metabolizing+genes.&rft.au=Figueroa%2C+Jonine+D%3BMalats%2C+N%C3%BAria%3BGarc%C3%ADa-Closas%2C+Montserrat%3BReal%2C+Francisco+X%3BSilverman%2C+Debra%3BKogevinas%2C+Manolis%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BDosemeci%2C+Mustafa%3BLan%2C+Qing%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BCasta%C3%B1o-Vinyals%2C+Gemma%3BRothman%2C+Nathaniel&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2008-10-01&rft.volume=29&rft.issue=10&rft.spage=1955&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn163 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-14 N1 - Date created - 2008-10-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2000 Oct;83(8):998-1002 [10993645] Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):969-78 [17507624] Biochem J. 2000 Oct 1;351(Pt 1):67-77 [10998348] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] J Biol Chem. 2002 Jul 5;277(27):24799-808 [11978787] Mutat Res. 2002 Sep 30;506-507:29-40 [12351142] Mutat Res. 2002 Sep 30;506-507:65-77 [12351146] Carcinogenesis. 2002 Nov;23(11):1839-49 [12419832] Cancer Lett. 2003 Dec 8;202(1):61-9 [14643027] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] World J Urol. 2004 Feb;21(6):382-91 [14648102] Curr Drug Metab. 2004 Jun;5(3):211-24 [15180491] Hematol Oncol Clin North Am. 1992 Feb;6(1):1-30 [1556044] Cancer Epidemiol Biomarkers Prev. 1992 Jan-Feb;1(2):149-53 [1306098] IARC Sci Publ. 1993;(124):331-40 [8225503] Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8413-7 [8078896] Oncol Res. 1994;6(10-11):525-32 [7620221] Br J Cancer. 1995 Sep;72(3):555-61 [7669561] Mutat Res. 1997 May 12;376(1-2):135-42 [9202749] Cancer Causes Control. 1997 May;8(3):346-55 [9498898] Cancer Causes Control. 1997 May;8(3):444-72 [9498904] J Biochem. 1998 Nov;124(5):940-6 [9792917] Toxicol Lett. 1998 Dec 28;102-103:173-83 [10022251] Pharmacogenetics. 1999 Feb;9(1):113-21 [10208650] Carcinogenesis. 2004 Nov;25(11):2177-81 [15284179] Genet Epidemiol. 2004 Dec;27(4):348-64 [15543638] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Nature. 2005 Oct 27;437(7063):1299-320 [16255080] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Pharmacogenomics J. 2007 Aug;7(4):282-9 [16983398] Arch Biochem Biophys. 2007 Aug 15;464(2):241-50 [17537398] Mutat Res. 2007 Dec 1;625(1-2):72-82 [17612574] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):979-87 [16702380] Nat Clin Pract Urol. 2006 Jun;3(6):327-40 [16763645] Toxicol Lett. 2006 Aug 20;165(2):182-94 [16713138] Expert Opin Drug Metab Toxicol. 2005 Aug;1(2):187-202 [16922636] Toxicol Lett. 2006 Dec 15;167(3):212-20 [17069994] PLoS Genet. 2007 Feb 23;3(2):e29 [17319747] Hum Genet. 2007 Apr;121(2):161-8 [17149600] Genet Epidemiol. 2000 Dec;19(4):323-32 [11108642] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn163 ER - TY - JOUR T1 - Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. AN - 69623489; 18658273 AB - Nanomaterials are frontier technological products used in different manufactured goods. Because of their unique physicochemical, electrical, mechanical, and thermal properties, single-walled carbon nanotubes (SWCNT) are finding numerous applications in electronics, aerospace devices, computers, and chemical, polymer, and pharmaceutical industries. SWCNT are relatively recently discovered members of the carbon allotropes that are similar in structure to fullerenes and graphite. Previously, we (47) have reported that pharyngeal aspiration of purified SWCNT by C57BL/6 mice caused dose-dependent granulomatous pneumonia, oxidative stress, acute inflammatory/cytokine responses, fibrosis, and decrease in pulmonary function. To avoid potential artifactual effects due to instillation/agglomeration associated with SWCNT, we conducted inhalation exposures using stable and uniform SWCNT dispersions obtained by a newly developed aerosolization technique (2). The inhalation of nonpurified SWCNT (iron content of 17.7% by weight) at 5 mg/m(3), 5 h/day for 4 days was compared with pharyngeal aspiration of varying doses (5-20 microg per mouse) of the same SWCNT. The chain of pathological events in both exposure routes was realized through synergized interactions of early inflammatory response and oxidative stress culminating in the development of multifocal granulomatous pneumonia and interstitial fibrosis. SWCNT inhalation was more effective than aspiration in causing inflammatory response, oxidative stress, collagen deposition, and fibrosis as well as mutations of K-ras gene locus in the lung of C57BL/6 mice. JF - American journal of physiology. Lung cellular and molecular physiology AU - Shvedova, A A AU - Kisin, E AU - Murray, A R AU - Johnson, V J AU - Gorelik, O AU - Arepalli, S AU - Hubbs, A F AU - Mercer, R R AU - Keohavong, P AU - Sussman, N AU - Jin, J AU - Yin, J AU - Stone, S AU - Chen, B T AU - Deye, G AU - Maynard, A AU - Castranova, V AU - Baron, P A AU - Kagan, V E AD - Health Effects Laboratory Div., National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. ats1@cdc.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - L552 EP - L565 VL - 295 IS - 4 SN - 1040-0605, 1040-0605 KW - Aerosols KW - 0 KW - Nanotubes, Carbon KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Carbon -- pharmacology KW - Animals KW - Pharynx KW - Aerosols -- administration & dosage KW - Fibrosis KW - Mice, Inbred C57BL KW - Mice KW - Female KW - Oxidative Stress -- drug effects KW - Lung -- drug effects KW - Inflammation -- etiology KW - Lung -- pathology KW - Administration, Inhalation KW - Nanotubes, Carbon -- adverse effects KW - Respiration Disorders -- chemically induced KW - Mutagenesis KW - Inflammation -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69623489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.atitle=Inhalation+vs.+aspiration+of+single-walled+carbon+nanotubes+in+C57BL%2F6+mice%3A+inflammation%2C+fibrosis%2C+oxidative+stress%2C+and+mutagenesis.&rft.au=Shvedova%2C+A+A%3BKisin%2C+E%3BMurray%2C+A+R%3BJohnson%2C+V+J%3BGorelik%2C+O%3BArepalli%2C+S%3BHubbs%2C+A+F%3BMercer%2C+R+R%3BKeohavong%2C+P%3BSussman%2C+N%3BJin%2C+J%3BYin%2C+J%3BStone%2C+S%3BChen%2C+B+T%3BDeye%2C+G%3BMaynard%2C+A%3BCastranova%2C+V%3BBaron%2C+P+A%3BKagan%2C+V+E&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2008-10-01&rft.volume=295&rft.issue=4&rft.spage=L552&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.issn=10400605&rft_id=info:doi/10.1152%2Fajplung.90287.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-10-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Crit Rev Toxicol. 2006 Mar;36(3):189-217 [16686422] J Nanosci Nanotechnol. 2006 Mar;6(3):591-9 [16573109] Int J Immunopathol Pharmacol. 2006 Oct-Dec;19(4 Suppl):3-10 [17291399] Br J Pharmacol. 2007 Mar;150(5):552-8 [17245366] Toxicol In Vitro. 2007 Apr;21(3):438-48 [17125965] Environ Health Perspect. 2007 Mar;115(3):377-82 [17431486] Environ Toxicol. 2007 Aug;22(4):415-21 [17607736] Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L87-97 [18024722] Expert Opin Drug Deliv. 2008 Mar;5(3):331-42 [18318654] Am J Respir Cell Mol Biol. 2008 May;38(5):579-90 [18096873] Inhal Toxicol. 2008 Jun;20(8):751-60 [18569097] Mol Cancer Ther. 2008 Jul;7(7):1913-22 [18645002] Environ Health Perspect. 2007 Aug;115(8):1125-31 [17687437] Am J Respir Crit Care Med. 2000 Jan;161(1):5-8 [10619790] Toxicol Sci. 2000 May;55(1):24-35 [10788556] Wien Klin Wochenschr. 2002 Mar 28;114(5-6):216-21 [12238312] J Toxicol Environ Health A. 2003 Aug 8;66(15):1441-52 [12857634] Free Radic Biol Med. 2003 Aug 15;35(4):327-40 [12899936] J Toxicol Environ Health A. 2004 Jan 9;67(1):87-107 [14668113] Toxicol Sci. 2004 Jan;77(1):126-34 [14514958] Toxicol Sci. 2004 Jan;77(1):117-25 [14514968] Int J Cancer. 2004 May 10;109(6):799-809 [15027112] Ann N Y Acad Sci. 2004 May;1013:1-16 [15194603] Mutat Res. 2004 Aug 8;562(1-2):119-31 [15279835] Philos Trans A Math Phys Eng Sci. 2004 Oct 15;362(1823):2065-98 [15370472] Cancer. 1973 May;31(5):1078-86 [4705148] Histochem J. 1979 Jul;11(4):447-55 [91593] Annu Rev Biochem. 1987;56:779-827 [3304147] Vopr Onkol. 1989;35(4):445-50 [2728386] Nature. 1990 Mar 15;344(6263):245-7 [2156165] Ann Clin Biochem. 1991 Sep;28 ( Pt 5):504-8 [1958055] Mol Carcinog. 1993;8(3):177-85 [8216736] Carcinogenesis. 1993 Nov;14(11):2419-22 [7902220] Cancer Metastasis Rev. 1994 Mar;13(1):67-89 [8143346] J Appl Physiol (1985). 1994 Sep;77(3):1060-6 [7836104] Environ Health Perspect. 1994 Oct;102 Suppl 5:173-9 [7882925] Fundam Appl Toxicol. 1995 Apr;25(1):80-94 [7541380] Inhal Toxicol. 1999 Aug;11(8):709-31 [10477444] Inhal Toxicol. 1996;8 Suppl:73-89 [11542496] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708 [15951334] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L696-7 [16214820] Toxicol Sci. 2006 Apr;90(2):400-18 [16410370] Toxicol Sci. 2006 Jul;92(1):5-22 [16484287] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1152/ajplung.90287.2008 ER - TY - JOUR T1 - Speak up about patient allergies. AN - 69593786; 18812983 JF - Nursing AU - Woo, Eileen AD - Center for Devices and Radiological Health. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 13 VL - 38 IS - 10 KW - Polyglactin 910 KW - 34346-01-5 KW - Nursing KW - United States KW - United States Food and Drug Administration KW - Humans KW - Polyglactin 910 -- adverse effects KW - Hypersensitivity -- immunology KW - Hypersensitivity -- physiopathology KW - Sutures -- adverse effects KW - Hypersensitivity -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69593786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing&rft.atitle=Speak+up+about+patient+allergies.&rft.au=Woo%2C+Eileen&rft.aulast=Woo&rft.aufirst=Eileen&rft.date=2008-10-01&rft.volume=38&rft.issue=10&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Nursing&rft.issn=1538-8689&rft_id=info:doi/10.1097%2F01.NURSE.0000337215.94183.46 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-04 N1 - Date created - 2008-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.NURSE.0000337215.94183.46 ER - TY - JOUR T1 - All hemoglobin-based oxygen carriers are not created equally. AN - 69590577; 18206989 AB - Hemoglobin (Hb)-based oxygen carriers (HBOCs) also known as "blood substitutes" have been under active clinical development over the last two decades. Cell-free Hb outside its natural protective red blood cell environment, as is the case with all HBOCs, has been shown to be vasoactive in part due to the scavenging of vascular endothelial nitric oxide (NO) and may in some instances induce heme-mediated oxidative stress. Chemical modification intended to stabilize HBOCs in the tetrameric or polymeric forms introduces conformational constraints that result in proteins with diverse allosteric responses as well as oxidative and nitrosative redox side reactions. Intra and inter-molecular cross-linking may in some instances also determine the interactions between HBOCs and normal oxidative inactivation and clearance mechanisms. Oxygen and oxidative reactions of normal and several cross-linked Hbs as well as their interactions with endogenous plasma protein (haptoglobin) and cellular receptor pathways (macrophage CD163) differ significantly. Therefore, safety and efficacy may be addressed by designing HBOCs with modifications that limit hypertension, minimize heme destabilization and take into account endogenous Hb removal mechanisms to optimize exposure times for a given indication. JF - Biochimica et biophysica acta AU - Buehler, Paul W AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology (LBVB), Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Maryland 20892, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1378 EP - 1381 VL - 1784 IS - 10 SN - 0006-3002, 0006-3002 KW - Blood Substitutes KW - 0 KW - Drug Carriers KW - HBOC 201 KW - Hemoglobins KW - Oxyhemoglobins KW - Heme KW - 42VZT0U6YR KW - Index Medicus KW - Drug Carriers -- therapeutic use KW - Hypertension -- chemically induced KW - Heme -- toxicity KW - Hypertension -- prevention & control KW - Humans KW - Drug Carriers -- chemistry KW - Hemoglobins -- therapeutic use KW - Oxyhemoglobins -- chemistry KW - Blood Substitutes -- chemistry KW - Blood Substitutes -- therapeutic use KW - Oxyhemoglobins -- toxicity KW - Oxyhemoglobins -- therapeutic use KW - Hemoglobins -- chemistry KW - Blood Substitutes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69590577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=All+hemoglobin-based+oxygen+carriers+are+not+created+equally.&rft.au=Buehler%2C+Paul+W%3BAlayash%2C+Abdu+I&rft.aulast=Buehler&rft.aufirst=Paul&rft.date=2008-10-01&rft.volume=1784&rft.issue=10&rft.spage=1378&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbapap.2007.12.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbapap.2007.12.009 ER - TY - JOUR T1 - Cytochrome c: a non-invasive biomarker of drug-induced liver injury. AN - 69583519; 18418843 AB - Limitations of existing biomarkers to detect liver injury in experimental animals highlight the need for additional tools to predict human toxicity. The utility of cytochrome c (cyt c) as a biomarker in serum and urine was evaluated in two rodent liver injury models. Adult Sprague-Dawley rats treated with acetaminophen or D-galactosamine (GalN) showed dose- and time-dependent histomorphological changes and TUNEL staining in liver consistent with hepatocellular necrosis, apoptosis and inflammation up to 72 h. Matching changes in serum alanine transaminase (ALT), aspartate transaminase (AST) and cyt c peaked at 24 h for either drug at the highest dose, cyt c falling rapidly at 48 hours with ALT and AST remained high. Intracellular transit of cyt c from mitochondria to the cytoplasm in damaged hepatocytes, and then to peripheral circulation, was observed by immunohistochemistry. Correlation coefficients between cyt c and serum diagnostic tests indicate the liver to be the primary source of cyt c. Urinary analysis for cyt c revealed time-dependent increase at 6 h, peaking at 24 h in GalN-treated rats in contrast with irregular patterns of urinary ALT and AST activity. Histological changes detected at 6 h preceded altered ALT, AST and cyt c at 12 and 18 h, respectively, in GalN-treated rats. These studies demonstrate cyt c to be a useful indicator of hepatic injury in rodents and support its utility as a non-invasive predictor of drug-induced hepatotoxicity, when utilized as a potential urinary biomarker. JF - Journal of applied toxicology : JAT AU - Miller, T J AU - Knapton, A AU - Adeyemo, O AU - Noory, L AU - Weaver, J AU - Hanig, J P AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. terry.miller@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 815 EP - 828 VL - 28 IS - 7 SN - 0260-437X, 0260-437X KW - Biomarkers KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Galactosamine KW - 7535-00-4 KW - Cytochromes c KW - 9007-43-6 KW - Index Medicus KW - Acute Disease KW - Animals KW - Hepatocytes -- drug effects KW - Dose-Response Relationship, Drug KW - Mitochondria -- enzymology KW - Disease Models, Animal KW - Hepatocytes -- pathology KW - Hepatocytes -- enzymology KW - Rats KW - Rats, Sprague-Dawley KW - Galactosamine -- toxicity KW - Necrosis -- chemically induced KW - Apoptosis -- drug effects KW - Mitochondria -- drug effects KW - Acetaminophen -- toxicity KW - Male KW - Chemical and Drug Induced Liver Injury -- etiology KW - Cytochromes c -- metabolism KW - Chemical and Drug Induced Liver Injury -- pathology KW - Biomarkers -- metabolism KW - Chemical and Drug Induced Liver Injury -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69583519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Cytochrome+c%3A+a+non-invasive+biomarker+of+drug-induced+liver+injury.&rft.au=Miller%2C+T+J%3BKnapton%2C+A%3BAdeyemo%2C+O%3BNoory%2C+L%3BWeaver%2C+J%3BHanig%2C+J+P&rft.aulast=Miller&rft.aufirst=T&rft.date=2008-10-01&rft.volume=28&rft.issue=7&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.1347 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-09-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jat.1347 ER - TY - JOUR T1 - Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. AN - 69566116; 18802068 AB - Nonalcoholic steatohepatitis (NASH), the most common cause of chronic liver fibrosis, progresses to cirrhosis in up to 20% of patients. We report that hepatic stellate cells (HSC) in sinusoidal lesions of liver of patients with NASH express high levels of high-affinity IL-13R (IL-13Ralpha2), which is colocalized with smooth muscle actin, whereas fatty liver and normal liver specimens do not express IL-13Ralpha2. HSCs engineered to overexpress IL-13Ralpha2 respond to IL-13 and induce TGFB1 promoter activity and TGF-beta1 production. We also developed NASH in rats by feeding a choline-deficient l-amino acid diet. These rats developed liver fibrosis as assessed by H&E staining, Masson's trichrome and Sirius red staining, and hydroxyproline assays. Treatment of these rats with IL-13R-directed cytotoxin caused a substantial decline in fibrosis and liver enzymes without organ toxicity. These studies demonstrate that functional IL-13Ralpha2 are overexpressed in activated HSCs involved in NASH and that IL-13 cytotoxin ameliorates pathological features of NASH in rat liver, indicating a novel role of this cytotoxin in potential therapy. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Shimamura, Takeshi AU - Fujisawa, Toshio AU - Husain, Syed R AU - Kioi, Mitomu AU - Nakajima, Atsushi AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/10/01/ PY - 2008 DA - 2008 Oct 01 SP - 4656 EP - 4665 VL - 181 IS - 7 KW - Cytotoxins KW - 0 KW - Exotoxins KW - IL13-PE38 KW - Interleukin-13 KW - Interleukin-13 Receptor alpha2 Subunit KW - RNA, Messenger KW - Receptors, Interleukin-13 KW - Recombinant Fusion Proteins KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Hepatic Stellate Cells -- pathology KW - Gene Expression Regulation -- immunology KW - Humans KW - Disease Models, Animal KW - Cell Line, Tumor KW - Interleukin-13 Receptor alpha2 Subunit -- biosynthesis KW - RNA, Messenger -- biosynthesis KW - Rats KW - Hepatic Stellate Cells -- metabolism KW - Rats, Inbred F344 KW - Interleukin-13 Receptor alpha2 Subunit -- physiology KW - Cells, Cultured KW - Interleukin-13 Receptor alpha2 Subunit -- genetics KW - Signal Transduction -- immunology KW - Hepatic Stellate Cells -- immunology KW - Male KW - Cell Line KW - Cytotoxins -- metabolism KW - Fatty Liver -- metabolism KW - Liver Cirrhosis -- therapy KW - Recombinant Fusion Proteins -- physiology KW - Fatty Liver -- immunology KW - Exotoxins -- physiology KW - Interleukin-13 -- physiology KW - Fatty Liver -- therapy KW - Interleukin-13 -- therapeutic use KW - Cytotoxins -- therapeutic use KW - Receptors, Interleukin-13 -- physiology KW - Liver Cirrhosis -- metabolism KW - Liver Cirrhosis -- immunology KW - Exotoxins -- therapeutic use KW - Recombinant Fusion Proteins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69566116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Novel+role+of+IL-13+in+fibrosis+induced+by+nonalcoholic+steatohepatitis+and+its+amelioration+by+IL-13R-directed+cytotoxin+in+a+rat+model.&rft.au=Shimamura%2C+Takeshi%3BFujisawa%2C+Toshio%3BHusain%2C+Syed+R%3BKioi%2C+Mitomu%3BNakajima%2C+Atsushi%3BPuri%2C+Raj+K&rft.aulast=Shimamura&rft.aufirst=Takeshi&rft.date=2008-10-01&rft.volume=181&rft.issue=7&rft.spage=4656&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-24 N1 - Date created - 2008-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment. AN - 69556004; 18798697 AB - The impact of an inflammatory response, as well as interactions between the immune and nervous systems, are rapidly assuming major roles in neurodegenerative disease and injury. However, it is now appreciated that the exact nature of such responses can differ with each type of insult and interaction. More recently, neuroinflammation and the associated cellular response of microglia are being considered for their contribution to neurotoxicity of environmental agents; yet, so far, the inclusion of inflammatory end points into neurotoxicity assessment have relied primarily on relatively limited measures or driven by in vitro models of neurotoxicity. To present background information on relevant biological considerations of neuroinflammation and the microglia response demonstrating the complex integrative nature of these biological processes and raising concern with regards to translation of effects demonstrated in vitro to the in vivo situation. Specific points are addressed that would influence the design and interpretation of neuroinflammation with regards to neurotoxicology assessment. There is a complex and dynamic response in the brain to regulate inflammatory processes and maintain a normal homeostatic level. The classification of such responses as beneficial or detrimental is an oversimplification. Neuroinflammation should be considered as a balanced network of processes in which subtle modifications can shift the cells toward disparate outcomes. The tendency to overinterpret data obtained in an isolated culture system should be discouraged. Rather, the use of cross-disciplinary approaches to evaluate several end points should be incorporated into the assessment of inflammatory contributions to the neurotoxicity of environmental exposures. JF - Expert opinion on drug metabolism & toxicology AU - Harry, Gaylia Jean AU - Kraft, Andrew D AD - National Institute of Environmental Health Sciences, National Institutes of Health, Neurotoxicology Group, Laboratory of Neurobiology, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. harry@niehs.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1265 EP - 1277 VL - 4 IS - 10 SN - 1742-5255, 1742-5255 KW - Inflammation Mediators KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Neurodegenerative Diseases -- metabolism KW - Cell Culture Techniques KW - Nervous System -- metabolism KW - Down-Regulation -- immunology KW - Nervous System -- pathology KW - Models, Biological KW - Inflammation Mediators -- metabolism KW - Neurotoxicity Syndromes -- diagnosis KW - Inflammation -- physiopathology KW - Neurotoxicity Syndromes -- etiology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69556004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Neuroinflammation+and+microglia%3A+considerations+and+approaches+for+neurotoxicity+assessment.&rft.au=Harry%2C+Gaylia+Jean%3BKraft%2C+Andrew+D&rft.aulast=Harry&rft.aufirst=Gaylia&rft.date=2008-10-01&rft.volume=4&rft.issue=10&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425255.4.10.1265 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci Res. 1998 Aug 1;53(3):361-7 [9698164] J Neurosci. 1998 Aug 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Immunol. 2007 Jan;28(1):12-8 [17129764] Brain Res. 2007 Feb 2;1131(1):17-28 [17161388] Nat Rev Immunol. 2007 Feb;7(2):161-7 [17220915] J Neuroimmunol. 2007 Feb;183(1-2):125-32 [17229471] J Neurosci. 2007 Mar 7;27(10):2596-605 [17344397] Brain Behav Immun. 2007 May;21(4):367-73 [17234380] Neuroreport. 2007 Mar 26;18(5):425-9 [17496797] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425255.4.10.1265 ER - TY - JOUR T1 - Use of flow cytometry in an apoptosis assay to determine pH and temperature stability of shiga-like toxin 1. AN - 69521417; 18710788 AB - Shiga toxins and Shiga-like toxins (Stx) are a relatively large group of cytotoxins produced by certain serotypes of Shigella and E. coli (STEC). These toxins are responsible for diarrhea, hemorrhagic colitis and may induce hemolytic uremic syndrome (HUS) with serious consequences in young children. The toxins are proteins made up of 5 small B subunits responsible for binding to an outer membrane ligand on host cells and surround the larger, biologically active A subunit. For Shiga-like toxin 1 (Stx1), the cellular receptor is the carbohydrate globotriose. Stx1was purified from STEC. We utilized induction of apoptosis in the human monocyte cell line THP-1, as a biological endpoint to test the stability of Stx1 activity added to fruit punch at different pH (2-9) and temperatures (4 and 20 degrees C). A flow cytometric method was used to test for early and late apoptotic events based on binding of R-phycoerytherin-labeled annexin V to exposed membrane phosphatidyl serine. Membrane permeability to 7-Amino-actinomycin corresponds with late apoptosis or necrosis. The combination of acid pH and higher storage temperature resulted in greatest degree of toxin inactivation. This approach provides a rapid and high throughput method to determine the functional activity of Stx1, and related toxins in a food matrix. JF - Journal of microbiological methods AU - Babu, Uma S AU - Gaines, Dennis M AU - Wu, Yang AU - Westphal, Carmen D AU - Pereira, Marion AU - Raybourne, Richard B AD - Immunobiology Branch, Division of Virulence Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Rd., Laurel, MD, 20708 USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 167 EP - 171 VL - 75 IS - 2 SN - 0167-7012, 0167-7012 KW - Shiga Toxin 1 KW - 0 KW - Index Medicus KW - Hydrogen-Ion Concentration KW - Humans KW - Temperature KW - Escherichia coli O157 -- metabolism KW - Cell Line KW - Shiga Toxin 1 -- chemistry KW - Apoptosis KW - Shiga Toxin 1 -- metabolism KW - Monocytes -- drug effects KW - Shiga Toxin 1 -- toxicity KW - Flow Cytometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69521417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+microbiological+methods&rft.atitle=Use+of+flow+cytometry+in+an+apoptosis+assay+to+determine+pH+and+temperature+stability+of+shiga-like+toxin+1.&rft.au=Babu%2C+Uma+S%3BGaines%2C+Dennis+M%3BWu%2C+Yang%3BWestphal%2C+Carmen+D%3BPereira%2C+Marion%3BRaybourne%2C+Richard+B&rft.aulast=Babu&rft.aufirst=Uma&rft.date=2008-10-01&rft.volume=75&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Journal+of+microbiological+methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2008.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-24 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mimet.2008.05.014 ER - TY - BOOK T1 - Personal Protective Equipment for Health Care Workers Who Work with Hazardous Drugs AN - 58783877; 2008-218165 AB - Health care workers who handle hazardous drugs are at risk of skin rashes, cancer, and reproductive disorders. NIOSH recommends that employers provide appropriate personal protective equipment (PPE) to protect workers who handle hazardous drugs in the workplace. References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Oct 2008, 4 pp. AU - National Inst Occupational Safety and Health Y1 - 2008/10// PY - 2008 DA - October 2008 EP - 4p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Health conditions and policy - Physicians, nurses, and other health personnel KW - Environment and environmental policy - Radioactive and dangerous substances KW - Manufacturing and heavy industry - Machinery and equipment industry KW - Manufacturing and heavy industry - Pharmaceutical industry KW - Business and service sector - Business operations, practices, and workplaces KW - Social conditions and policy - Public safety and security KW - Equipment KW - Hazardous materials KW - Medical workers KW - Safety measures KW - Workplaces KW - Drugs KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58783877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Inst+Occupational+Safety+and+Health&rft.aulast=National+Inst+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2008-10-01&rft.volume=&rft.issue=&rft.spage=4p&rft.isbn=&rft.btitle=Personal+Protective+Equipment+for+Health+Care+Workers+Who+Work+with+Hazardous+Drugs&rft.title=Personal+Protective+Equipment+for+Health+Care+Workers+Who+Work+with+Hazardous+Drugs&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/wp-solutions/2009-106/default.html LA - English DB - PAIS Index N1 - Date revised - 2009-01-09 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - SuppNotes - NIOSH Publication No. 2009-106 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Physical victimization in prison: The role of mental illness AN - 57297086; 200913800 AB - This study compares prison physical victimization rates (inmate-on-inmate and staff-on-inmate) for people with mental disorder to those without mental disorder in a state prison system. Inmate subjects were drawn from 14 adult prisons operated by a single mid-Atlantic State. A sample of 7528 subjects aged 18 or older (7221 men and 564 women) completed an audio-computer administered survey instrument. Mental disorder was based on self-reported mental health treatment ever for particular mental disorders. Approximately one-quarter of the sample reported some prior treatment for schizophrenia, bipolar disorder, depression, PTSD, or anxiety disorder. Rates of physical victimization for males with any mental disorder were 1.6 times (inmate-on-inmate) and 1.2 times (staff-on-inmate) higher than that of males with no mental disorder. Female inmates with mental disorder were 1.7 times more likely to report being physically victimized by another inmate than did their counterparts with no mental disorder. Overall, both males and females with mental disorder are disproportionately represented among victims of physical violence inside prison. Adapted from the source document. JF - International Journal of Law and Psychiatry AU - Blitz, Cynthia L AU - Wolff, Nancy AU - Shi, Jing AD - Center for Mental Health Services & Criminal Justice Research, Rutgers University, New Brunswick, N.J., USA clblitz@rci.rutgers.edu Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 385 EP - 393 PB - Elsevier Ltd., The Netherlands VL - 31 IS - 5 SN - 0160-2527, 0160-2527 KW - Physical victimization Prison Mental illness KW - Prisons KW - Mental health services KW - Men KW - Psychiatric disorders KW - Prisoners KW - Victimization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57297086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Law+and+Psychiatry&rft.atitle=Physical+victimization+in+prison%3A+The+role+of+mental+illness&rft.au=Blitz%2C+Cynthia+L%3BWolff%2C+Nancy%3BShi%2C+Jing&rft.aulast=Blitz&rft.aufirst=Cynthia&rft.date=2008-10-01&rft.volume=31&rft.issue=5&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Law+and+Psychiatry&rft.issn=01602527&rft_id=info:doi/10.1016%2Fj.ijlp.2008.08.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - CODEN - IJLPDI N1 - SubjectsTermNotLitGenreText - Psychiatric disorders; Prisons; Prisoners; Victimization; Mental health services; Men DO - http://dx.doi.org/10.1016/j.ijlp.2008.08.005 ER - TY - JOUR T1 - Expanding the Role of Health Services Research as a Tool to Reduce the Public Health Burden of Alcohol Use Disorders AN - 57279731; 200903429 AB - The public and private cost of 'heavy alcohol use'1 is estimated to be more than 187 billion in lost productivity, health care and criminal justice expenditures, and other costs. This does not include the emotional and psychological costs to family, friends, and the community. Investments by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have led to a number of important advances in pharmacological and behavioral treatments for alcohol disorders. Yet, there continues to be a significant gap between research findings and progress in community-based care. Additionally, limited capacity, a lack of acknowledged standards, and a separation between the specialty substance use treatment sector and general medical practice contribute to this gap. As part of its ongoing efforts to encourage translation from clinical research to practice, NIAAA undertook a review of its alcohol related health services research program for the purpose of creating a vision for the next 10 yr that is sensitive to the changing needs of both the clinical and research communities. Central to the development of a new research agenda is a reconceptualization of alcohol use and misuse along a continuum that takes into account quantity and frequency of use as well as the consequences from 'heavy use' and misuse of alcohol. This public health approach recommends a number of high priority areas to expand and improve the system of care for 'heavy alcohol users' who may be at-risk or who may have developed an alcohol use disorder. These recommendations include research on dissemination and implementation of evidence-based practices, and improving access and utilization to care for individuals who are 'heavy users.' The paper concludes by outlining some of the steps taken by NIAAA to further the continuing development of alcohol health services research. Adapted from the source document. JF - Substance Use & Misuse AU - Delany, Peter J AU - Shields, Joseph J AU - Willenbring, Mark L AU - Huebner, Robert B AD - Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1729 EP - 1746 PB - Taylor & Francis, Philadelphia PA VL - 43 IS - 12 SN - 1082-6084, 1082-6084 KW - Alcohol consumption KW - Alcoholism KW - Heavy drinking KW - Community care KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57279731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Expanding+the+Role+of+Health+Services+Research+as+a+Tool+to+Reduce+the+Public+Health+Burden+of+Alcohol+Use+Disorders&rft.au=Delany%2C+Peter+J%3BShields%2C+Joseph+J%3BWillenbring%2C+Mark+L%3BHuebner%2C+Robert+B&rft.aulast=Delany&rft.aufirst=Peter&rft.date=2008-10-01&rft.volume=43&rft.issue=12&rft.spage=1729&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1080%2F10826080802345341 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Alcohol consumption; Alcoholism; Heavy drinking; Public health; Community care DO - http://dx.doi.org/10.1080/10826080802345341 ER - TY - JOUR T1 - Use of progression-free survival as a surrogate marker in oncology trials: some regulatory issues AN - 57257401; 200823285 AB - There has been interest in using progression-free survival as a surrogate endpoint for overall survival in oncology clinical trials. In order to objectively define this endpoint, clear understanding of what progression means, how it is measured and what its implications are need to be discussed. This article discusses some regulatory aspects of using progression-free survival as an endpoint. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Chakravarty, Aloka AU - Sridhara, Rajeshwari AD - Office of Biostatistics, Center for Drug Evaluation and Research, FDA, MD, USA aloka.chakravarty@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 515 EP - 518 PB - Hodder Arnold, London UK VL - 17 IS - 5 SN - 0962-2802, 0962-2802 KW - Statistics KW - Oncology KW - Regulation KW - Clinical trials KW - Markers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57257401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Use+of+progression-free+survival+as+a+surrogate+marker+in+oncology+trials%3A+some+regulatory+issues&rft.au=Chakravarty%2C+Aloka%3BSridhara%2C+Rajeshwari&rft.aulast=Chakravarty&rft.aufirst=Aloka&rft.date=2008-10-01&rft.volume=17&rft.issue=5&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280207081862 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-12-09 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Oncology; Regulation; Clinical trials; Statistics; Markers DO - http://dx.doi.org/10.1177/0962280207081862 ER - TY - JOUR T1 - An Analysis of Factors Underlying E-Health Disparities AN - 57257140; 200900064 AB - Discusses e-health disparities in terms of differences in Internet access, information seeking, & literacy. A user-centered approach to consumer e-health is outlined. Adapted from the source document. JF - Cambridge Quarterly of Healthcare Ethics AU - Baur, Cynthia AD - Division of Health Communication and Marketing, National Center for Health Marketing, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Washington, DC Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 417 EP - 428 PB - Cambridge University Press, New York NY VL - 17 IS - 4 SN - 0963-1801, 0963-1801 KW - Information seeking KW - Consumers KW - Literacy KW - Internet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57257140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cambridge+Quarterly+of+Healthcare+Ethics&rft.atitle=An+Analysis+of+Factors+Underlying+E-Health+Disparities&rft.au=Baur%2C+Cynthia&rft.aulast=Baur&rft.aufirst=Cynthia&rft.date=2008-10-01&rft.volume=17&rft.issue=4&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Cambridge+Quarterly+of+Healthcare+Ethics&rft.issn=09631801&rft_id=info:doi/10.1017%2FS0963180108080547 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Internet; Consumers; Literacy; Information seeking DO - http://dx.doi.org/10.1017/S0963180108080547 ER - TY - JOUR T1 - Trends in Racial Disparities Among the Elderly for Selected Procedures AN - 57252805; 200823189 AB - The authors examine trends over 1997-2001 in racial or ethnic disparities in the utilization of three costly, referral-sensitive procedures among the elderly-coronary artery bypass grafting (CABG), percutaneous transluminal coronary angioplasty (PTCA), and hip/joint replacement. Using a multivariate framework, they undertake a simultaneous examination of the relationships between patient, local area context, and health systems on these admission types after comparing them to a control group. This period spans the implementation of the Balanced Budget Act and a major Department of Health and Human Services initiative to reduce disparities in cardiovascular and other diseases. Findings suggest increasing disparities for African Americans relative to Whites in their lower utilization of CABG and PTCA over time, and increasing disparities in the utilization of hip/joint replacement among other races' relative to Whites. The authors find that racial or ethnic disparities in use of referral-sensitive procedures did not narrow over 1997-2001. [Copyright 2008 Sage Publications, Inc.] JF - Medical Care Research and Review AU - Basu, Jayasree AU - Mobley, Lee R AD - Agency for Healthcare Research and Quality, Rockville, Maryland Jayasree.basu@ahrq.hhs.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 617 EP - 637 PB - Sage Publications, Thousand Oaks CA VL - 65 IS - 5 SN - 1077-5587, 1077-5587 KW - racial disparities CABG PTCA hip/joint replacement referral-sensitive procedures elderly KW - Elderly people KW - Health inequalities KW - Referrals KW - Medical services KW - Racial inequalities KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57252805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=Trends+in+Racial+Disparities+Among+the+Elderly+for+Selected+Procedures&rft.au=Basu%2C+Jayasree%3BMobley%2C+Lee+R&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2008-10-01&rft.volume=65&rft.issue=5&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558708318284 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-12-09 N1 - Last updated - 2016-09-27 N1 - CODEN - MCRRFH N1 - SubjectsTermNotLitGenreText - Health inequalities; Racial inequalities; Elderly people; Referrals; Medical services DO - http://dx.doi.org/10.1177/1077558708318284 ER - TY - JOUR T1 - Host Biomarkers and Biological Pathways That Are Associated with the Expression of Experimental Cerebral Malaria in Mice AN - 21508659; 12495206 AB - Cerebral malaria (CM) is a primary cause of malaria-associated deaths among young African children. Yet no diagnostic tools are available that could be used to predict which of the children infected with Plasmodium falciparum malaria will progress to CM. We used the Plasmodium berghei ANKA murine model of experimental cerebral malaria (ECM) and high-density oligonucleotide microarray analyses to identify host molecules that are strongly associated with the clinical symptoms of ECM. Comparative expression analyses were performed with C57BL/6 mice, which have an ECM-susceptible phenotype, and with mice that have ECM-resistant phenotypes: CD8 knockout and perforin knockout mice on the C57BL/6 background and BALB/c mice. These analyses allowed the identification of more than 200 host molecules (a majority of which had not been identified previously) with altered expression patterns in the brain that are strongly associated with the manifestation of ECM. Among these host molecules, brain samples from mice with ECM expressed significantly higher levels of p21, metallothionein, and hemoglobin 1 proteins by Western blot analysis than mice unaffected by ECM, suggesting the possible utility of these molecules as prognostic biomarkers of CM in humans. We suggest that the higher expression of hemoglobin 1 in the brain may be associated with ECM and could be a source of excess heme, a molecule that is considered to trigger the pathogenesis of CM. Our studies greatly enhance the repertoire of host molecules for use as diagnostics and novel therapeutics in CM. JF - Infection and Immunity AU - Oakley, Miranda S AU - McCutchan, Thomas F AU - Anantharaman, Vivek AU - Ward, Jerrold M AU - Faucette, Laurence AU - Erexson, Cindy AU - Mahajan, Babita AU - Zheng, Hong AU - Majam, Victoria AU - Aravind, L AU - Kumar, Sanjai AD - Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Sanjai.kumar@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 4518 EP - 4529 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 10 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; CSA Neurosciences Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Symptoms KW - Parasites KW - Human diseases KW - Heme KW - Metallothionein KW - Animal models KW - Malaria KW - Oligonucleotides KW - Phenotypes KW - Public health KW - Hemoglobin KW - Western blotting KW - Perforin KW - Chromium KW - Brain KW - Plasmodium falciparum KW - CD8 antigen KW - Immunity KW - Children KW - biomarkers KW - Plasmodium berghei KW - Extracellular matrix KW - Africa KW - Haemoglobins KW - K 03410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21508659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Host+Biomarkers+and+Biological+Pathways+That+Are+Associated+with+the+Expression+of+Experimental+Cerebral+Malaria+in+Mice&rft.au=Oakley%2C+Miranda+S%3BMcCutchan%2C+Thomas+F%3BAnantharaman%2C+Vivek%3BWard%2C+Jerrold+M%3BFaucette%2C+Laurence%3BErexson%2C+Cindy%3BMahajan%2C+Babita%3BZheng%2C+Hong%3BMajam%2C+Victoria%3BAravind%2C+L%3BKumar%2C+Sanjai&rft.aulast=Oakley&rft.aufirst=Miranda&rft.date=2008-10-01&rft.volume=76&rft.issue=10&rft.spage=4518&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00525-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Symptoms; Human diseases; Brain; Malaria; Immunity; Phenotypes; Haemoglobins; Public health; Perforin; Western blotting; Metallothionein; Chromium; Heme; Animal models; CD8 antigen; Children; biomarkers; Oligonucleotides; Hemoglobin; Extracellular matrix; Plasmodium falciparum; Plasmodium berghei; Africa DO - http://dx.doi.org/10.1128/IAI.00525-08 ER - TY - JOUR T1 - Transformation of N-Phenylpiperazine by Mixed Cultures from a Municipal Wastewater Treatment Plant AN - 21506980; 12494840 AB - Samples from a wastewater treatment plant were used as inocula for mixed cultures dosed with N-phenylpiperazine (NPP), a model compound containing the piperazine ring found in many fluoroquinolones. Chemical analyses showed that NPP (50 mg liter-1) disappeared in 12 days, with the appearance of a transient metabolite and two nitrosated compounds. JF - Applied and Environmental Microbiology AU - Jung, Carina M AU - Heinze, Thomas M AU - Deck, Joanna AU - Strakosha, Ruth AU - Sutherland, John B AD - Divisions of Microbiology, john.sutherland@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 6147 EP - 6150 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 74 IS - 19 SN - 0099-2240, 0099-2240 KW - Aqualine Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Water Resources Abstracts KW - Chemical Analysis KW - Wastewater Facilities KW - Mixed culture KW - AQ 00006:Sewage KW - SW 3040:Wastewater treatment processes KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21506980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Transformation+of+N-Phenylpiperazine+by+Mixed+Cultures+from+a+Municipal+Wastewater+Treatment+Plant&rft.au=Jung%2C+Carina+M%3BHeinze%2C+Thomas+M%3BDeck%2C+Joanna%3BStrakosha%2C+Ruth%3BSutherland%2C+John+B&rft.aulast=Jung&rft.aufirst=Carina&rft.date=2008-10-01&rft.volume=74&rft.issue=19&rft.spage=6147&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00516-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Mixed culture; Wastewater Facilities DO - http://dx.doi.org/10.1128/AEM.00516-08 ER - TY - RPRT T1 - A Maintenance Worker Dies When He Falls Off the Roof of an Apartment Building AN - 20967516; 11069909 AB - A 42-year-old Hispanic maintenance worker died when he fell from the flat roof of a three-story apartment building. The victim was working by himself repairing a leak in the roof at the time of the incident. There were no warning lines or perimeter barriers on the roof and the victim was not using any personal fall protection equipment. The employer of the victim did not have any safety or training programs available for their employees. The CA/FACE investigator determined that, in order to prevent future occurrences, employers should: Ensure fall protection is used by workers performing roof repairs. Develop and implement a safety and training program for employees to follow. In addition: Building owners should consider the installation of guardrails around the perimeter of flat roofs wherever feasible. JF - A Maintenance Worker Dies When He Falls Off the Roof of an Apartment Building. [np]. 2008. AU - Anonymous Y1 - 2008/10// PY - 2008 DA - Oct 2008 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Housing KW - Training KW - Protective equipment KW - Maintenance KW - Residential areas KW - Ethnic groups KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20967516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Maintenance+Worker+Dies+When+He+Falls+Off+the+Roof+of+an+Apartment+Building&rft.title=A+Maintenance+Worker+Dies+When+He+Falls+Off+the+Roof+of+an+Apartment+Building&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Many different tumor types have polyclonal tumor origin: Evidence and implications AN - 20942936; 8467740 AB - Few ideas have gained such strong acceptance in the scientific community as the monoclonal origin of tumors; the idea that tumors start with a single mutated cell (or a single clone of cells) that go on to accumulate additional mutations as a tumor develops. The certainty with which this concept is held by the scientific community reflects the length of time it has been unchallenged and the experimental difficulty in obtaining direct evidence to the contrary. Yet, recent findings regarding X chromosome inactivation patch size indicate that the X-linked marker data previously interpreted as evidence of monoclonal tumor origin is actually more consistent with polyclonal tumor origin, a situation where two or more cells or clones of cells interact to initiate a tumor. Although most tumors show homotypy for X-linked markers (as expected given the bias conferred by X chromosome inactivation patch size), the literature contains numerous examples of tumors with X-linked marker heterotypy, examples of which encompass 24 different tumor types. Chimeric models have yielded direct unequivocal demonstrations of polyclonality in rodent and human tumors. Also, mutational data are consistent with polyclonal tumor origin. Methods that analyze levels of tumor-associated oncogene and tumor suppressor gene mutations demonstrate that initiated cells are much more common in normal tissues than previously realized. Also, while tumors have higher levels of mutation than normal tissues, oncogenic mutations frequently are present as subpopulations within tumors, rather than as the pure mutant populations expected to develop from a single initiated cell. Understanding the mutational basis of tumor etiology has important practical significance for assessing cancer risk, as well as in modeling and treating cancer. Therefore, the scientific community needs to re-examine this issue and consider the implications of polyclonal origin for, perhaps, a majority of tumors, encompassing many different tumor types. reaction JF - Mutation Research-Reviews in Mutation Research AU - Parsons, B L AD - National Center for Toxicological Research, HFT-120, 3900 NCTR Road, USFDA, Jefferson, AR 72079, United States, barbara.parsons@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 232 EP - 247 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 659 IS - 3 SN - 1383-5742, 1383-5742 KW - Genetics Abstracts; Toxicology Abstracts KW - Tumor suppressor genes KW - Etiology KW - Data processing KW - Oncogenes KW - X chromosome KW - Animal models KW - X-chromosome inactivation KW - Tumors KW - Cancer KW - G 07730:Development & Cell Cycle KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20942936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Reviews+in+Mutation+Research&rft.atitle=Many+different+tumor+types+have+polyclonal+tumor+origin%3A+Evidence+and+implications&rft.au=Parsons%2C+B+L&rft.aulast=Parsons&rft.aufirst=B&rft.date=2008-10-01&rft.volume=659&rft.issue=3&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Reviews+in+Mutation+Research&rft.issn=13835742&rft_id=info:doi/10.1016%2Fj.mrrev.2008.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Etiology; Oncogenes; Data processing; X chromosome; Animal models; X-chromosome inactivation; Tumors; Cancer DO - http://dx.doi.org/10.1016/j.mrrev.2008.05.004 ER - TY - JOUR T1 - Campylobacter-Induced Interleukin-8 Secretion in Polarized Human Intestinal Epithelial Cells Requires Campylobacter-Secreted Cytolethal Distending Toxin- and Toll-Like Receptor-Mediated Activation of NF-B AN - 20942124; 8488124 AB - Campylobacter jejuni and Campylobacter coli colonize and infect the intestinal epithelium and cause acute inflammatory diarrhea. The intestinal epithelium serves as a physical barrier to, and a sensor of, bacterial infection by secreting proinflammatory cytokines. This study examined the mechanisms for Campylobacter-induced secretion of the proinflammatory chemokine interleukin-8 (IL-8) by using polarized T84 human colonic epithelial cells as a model. C. jejuni increased the secretion of both IL-8 and tumor necrosis factor alpha (TNF-a) in polarized epithelial cells. However, the increase in IL-8 secretion was independent of Campylobacter-stimulated TNF-a secretion. Polarized T84 cells secreted IL-8 predominantly to the basolateral medium independently of the inoculation direction. While there was a significant correlation between the levels of IL-8 secretion and Campylobacter invasion, all 11 strains tested increased IL-8 secretion by polarized T84 cells despite their differences in adherence, invasion, and transcytosis efficiencies. Cell-free supernatants of Campylobacter-T84-cell culture increased IL-8 secretion to levels similar to those induced by live bacterial inoculation. The ability of the supernatant to induce IL-8 secretion was reduced by flagellum and cytolethal distending toxin (CDT) gene mutants, treatment of the supernatant with protease K or heat, or treatment of T84 cells with the Toll-like receptor (TLR) inhibitor MyD88 inhibitory peptide or chloroquine. NF-B inhibitors or cdtB mutation plus MyD88 inhibitor, but not flaA cdtB double mutations, abolished the ability of the supernatant to induce IL-8 secretion. Taken together, our results demonstrate that Campylobacter-induced IL-8 secretion requires functional flagella and CDT and depends on the activation of NF-B through TLR signaling and CDT in human intestinal epithelial cells. JF - Infection and Immunity AU - Zheng, Jie AU - Meng, Jianghong AU - Zhao, Shaohua AU - Singh, Ruby AU - Song, Wenxia AD - Department of Nutrition and Food Science. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742. Center for Veterinary Medicine, Office of Research, Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 4498 EP - 4508 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 10 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Epithelial cells KW - Chemokines KW - FlaA protein KW - Cell culture KW - Infection KW - Interleukin 8 KW - Campylobacter jejuni KW - Epithelium KW - cytolethal distending toxin KW - Diarrhea KW - MyD88 protein KW - Campylobacter coli KW - Chloroquine KW - Tumor necrosis factor-a KW - Endopeptidase K KW - Inflammation KW - Heat KW - NF-B protein KW - Inoculation KW - Intestine KW - Mutation KW - Toll-like receptors KW - Flagella KW - Signal transduction KW - X 24310:Pharmaceuticals KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20942124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Campylobacter-Induced+Interleukin-8+Secretion+in+Polarized+Human+Intestinal+Epithelial+Cells+Requires+Campylobacter-Secreted+Cytolethal+Distending+Toxin-+and+Toll-Like+Receptor-Mediated+Activation+of+NF-B&rft.au=Zheng%2C+Jie%3BMeng%2C+Jianghong%3BZhao%2C+Shaohua%3BSingh%2C+Ruby%3BSong%2C+Wenxia&rft.aulast=Zheng&rft.aufirst=Jie&rft.date=2008-10-01&rft.volume=76&rft.issue=10&rft.spage=4498&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - cytolethal distending toxin; Epithelial cells; Chemokines; Diarrhea; FlaA protein; MyD88 protein; Chloroquine; Cell culture; Infection; Tumor necrosis factor-a; Endopeptidase K; Interleukin 8; Inflammation; Heat; NF-B protein; Intestine; Inoculation; Epithelium; Mutation; Toll-like receptors; Signal transduction; Flagella; Campylobacter jejuni; Campylobacter coli ER - TY - JOUR T1 - A radiation force technique for acoustic power calibration of high intensity focused ultrasound transducers AN - 20810023; 10961575 AB - It is essential to know the acoustic power radiated by transducers used in high intensity focused ultrasound (HIFU) surgery devices for both safety and effectiveness considerations. The power radiated by medical ultrasound transducers usually is measured via radiation force balance (RFB) methods. However, for the high power focused fields encountered in HIFU applications, such measurements can be difficult due to the need for short measurement times to prevent transducer damage, heating of the RFB target, and bubble formation. To address these challenges, a procedure based on pulsed measurements was formulated. High output focused ultrasound transducers were characterized in terms of an effective duty factor, which was then used to calculate the power during the pulse at high drive levels. Two absorbing target designs were used, and both gave reliable results and displayed no damage and minimal temperature rise if placed near the HIFU transducer and away from the focus. The procedure was reproducible up to the maximum power generated of approximately 230 W, representative of the HIFU range, thus allowing the radiated power to be calibrated in terms of the peak-to-peak voltage applied to the transducer. JF - Journal of the Acoustical Society of America AU - Maruvada, S AD - U.S. Food and Drug Administration, 10903 New Hampshire Ave., Bldg. WO62-2222, Silver Spring, MD 20993, USA Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 2566 VL - 124 IS - 4 SN - 0001-4966, 0001-4966 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - alpha Radiation KW - Radiation KW - Acoustics KW - Surgery KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20810023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=A+radiation+force+technique+for+acoustic+power+calibration+of+high+intensity+focused+ultrasound+transducers&rft.au=Maruvada%2C+S&rft.aulast=Maruvada&rft.aufirst=S&rft.date=2008-10-01&rft.volume=124&rft.issue=4&rft.spage=2566&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; alpha Radiation; Radiation; Acoustics; Surgery; Ultrasound ER - TY - JOUR T1 - Stability of Picrotoxin during Yogurt Manufacture and Storage AN - 20731778; 8646591 AB - Picrotoxin is a neurotoxin found in the berries of Anamirta cocculus, a plant native to Southeast Asia. Picrotoxin has potential for being used as a biological weapon since the toxin is relatively easy to isolate and purify. Limited information exists on the stability and detection of picrotoxin added to foods before or after processing. The objective of this study was to determine the stability of picrotoxin during yogurt manufacture and storage. Direct, cup-set yogurt was produced by using methods that mimic the conditions used in full-scale production of yogurt. Milk (full-fat or low-fat) was pasteurized at 85 degree C for 30 min, and then cooled to 43 degree C. Yogurt starter culture (thermophilic culture or thermophilic + probiotic culture) and picrotoxin (200 mu g-mL milk) were added. Samples of yogurt during fermentation (5 to 6 h, 43 degree C) and during 30 d refrigerated (4 to 6 degree C) storage were analyzed for pH, titratable acidity, and picrototoxin levels. Regardless of starter culture used or fat content of milk, there were no significant differences in the pH and titratable acidities of the picrotoxin-spiked yogurt and the control yogurt (no added picrotoxin) during fermentation and up to 4 wk of refrigerated storage. The color or texture of the yogurt was not affected by addition of picrotoxin. Levels of picrotoxinin and picrotin (components of picrotoxin) in yogurt, as measured by LC-MS (APCI super(+)-SIR) did not change significantly during fermentation and storage. A separate experiment determined that addition of picrotoxin to milk before pasteurization (85 degree C, 30 min) did not affect picrotoxin stability. These results indicate that picrotoxin is stable in yogurt during manufacture and storage. JF - Journal of Food Science AU - Jablonski, JE AU - Jackson, L S AD - U.S. Food and Drug Administration (FDA), Natl. Center for Food Safety & Technology (NCFST), 6502 S. Archer Rd., Summit-Argo, IL 60501, U.S.A. Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - T121 EP - T128 PB - Institute of Food Technology VL - 73 IS - 8 SN - 0022-1147, 0022-1147 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - liquid chromatography-mass spectrometry (LC-MS) KW - manufacture KW - picrotoxin KW - stability KW - yogurt KW - Fruits KW - Starter cultures KW - Milk KW - Fermentation KW - Food KW - probiotics KW - Cocculus KW - Pasteurization KW - Color KW - Yogurt KW - Cold storage KW - Neurotoxins KW - Acidity KW - pH effects KW - J 02330:Biochemistry KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20731778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Stability+of+Picrotoxin+during+Yogurt+Manufacture+and+Storage&rft.au=Jablonski%2C+JE%3BJackson%2C+L+S&rft.aulast=Jablonski&rft.aufirst=JE&rft.date=2008-10-01&rft.volume=73&rft.issue=8&rft.spage=T121&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2Fj.1750-3841.2008.00911.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Starter cultures; Fruits; Milk; Fermentation; Food; probiotics; Pasteurization; Color; Yogurt; Cold storage; picrotoxin; Acidity; Neurotoxins; pH effects; Cocculus DO - http://dx.doi.org/10.1111/j.1750-3841.2008.00911.x ER - TY - JOUR T1 - Does increased urination frequency protect against bladder cancer? AN - 20625844; 9355814 AB - Experimental studies suggest that increased urination frequency may reduce bladder cancer risk if carcinogens are present in the urine. Only 2 small studies of the effect of increased urination frequency on bladder cancer risk in humans have been conducted with conflicting results. Our purpose was to evaluate the effect of urination frequency on risk of bladder cancer in a large, multicenter case-control study. We analyzed data based on interviews conducted with 884 patients with newly diagnosed, bladder cancer and 996 controls from 1998 to 2001 in Spain. We observed a consistent, inverse trend in risk with increasing nighttime voiding frequency in both men (p = 0.0003) and women (p = 0.07); voiding at least 2 times per night was associated with a significant, 40-50% risk reduction. The protective effect of nocturia was apparent among study participants with low, moderate and high water consumption. The risk associated with cigarette smoking was reduced by nocturia. Compared with nonsmokers who did not urinate at night, current smokers who did not urinate at night had an OR of 7.0 (95% CI = 4.7-10.2), whereas those who voided at least twice per night had an OR of 3.3 (95% CI = 1.9-5.8) (p value for trend = 0.0005). Our findings suggest a strong protective effect of nocturia on bladder cancer risk, providing evidence in humans that bladder cancer risk is related to the contact time of the urothelium with carcinogens in urine. Increased urination frequency, coupled with possible dilution of the urine from increased water intake, may diminish the effect of urinary carcinogens on bladder cancer risk. JF - International Journal of Cancer AU - Silverman, Debra T AU - Alguacil, Juan AU - Rothman, Nathaniel AU - Real, Francisco X AU - Garcia-Closas, Montserrat AU - Cantor, Kenneth P AU - Malats, Nuria AU - Tardon, Adonina AU - Serra, Consol AU - Garcia-Closas, Reina AU - Carrato, Alfredo AU - Lloreta, Josep AU - Samanic, Claudine AU - Dosemeci, Mustafa AU - Kogevinas, Manolis AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, silvermd@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1644 EP - 1648 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 7 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - water use KW - urinary bladder KW - risk reduction KW - Urine KW - Spain KW - Cigarette smoking KW - Carcinogens KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20625844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Does+increased+urination+frequency+protect+against+bladder+cancer%3F&rft.au=Silverman%2C+Debra+T%3BAlguacil%2C+Juan%3BRothman%2C+Nathaniel%3BReal%2C+Francisco+X%3BGarcia-Closas%2C+Montserrat%3BCantor%2C+Kenneth+P%3BMalats%2C+Nuria%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BGarcia-Closas%2C+Reina%3BCarrato%2C+Alfredo%3BLloreta%2C+Josep%3BSamanic%2C+Claudine%3BDosemeci%2C+Mustafa%3BKogevinas%2C+Manolis&rft.aulast=Silverman&rft.aufirst=Debra&rft.date=2008-10-01&rft.volume=123&rft.issue=7&rft.spage=1644&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23572 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - water use; risk reduction; urinary bladder; Urine; Cigarette smoking; Carcinogens; Cancer; Spain DO - http://dx.doi.org/10.1002/ijc.23572 ER - TY - JOUR T1 - Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy AN - 20466398; 9146572 AB - SummaryBackground:Topiramate was approved for the treatment of epilepsy in 1999 and has since been approved for the prevention of migraine headache. It is structurally different from the majority of antiepileptic medications and is pharmacodynamically unique in its ability to inhibit the enzyme carbonic anhydrase. Postmarketing reports of topiramate-associated hypothermia have occurred but this adverse event has not been well characterized. Data mining of an adverse event database was used to assist in the identification of hypothermia.Objective:We sought to explore a possible association between the concomitant use of topiramate and valproic acid and the induction of hypothermia.Methods:This was a pharmacovigilance case series survey of spontaneous hypothermia, a reported adverse event in patients treated with topiramate and valproic acid, alone and in combination. The U.S. Food and Drug Administration's Adverse Events Reporting System (AERS) database was searched for reports of hypothermia in association with the use of topiramate. A data mining algorithm was used on the AERS to identify scores for hypothermia associated with antiepileptic drugs.Results:We identified 22 unduplicated reports of hypothermia in patients exposed to topiramate. Three of the 22 were confounded by patient overdoses with multiple drugs and not considered. Use of more than one antiepileptic drug was reported in most of the remaining 19 reports. Of these 19 reports, valproic acid was mentioned in 7. Two of the 19 reports mentioned topiramate only. Eleven of the 19 patients were men. The median age of the 19 patients was 40years (range, 3[frac12] - 82years). Body temperatures ranged from 29.5 degree C (moderate hypothermia) to 35 degree C (mild hypothermia) with a median of 34 degree C. Eleven of 18 reports of hypothermia occurred during the cooler months (one report did not indicate the time of year in which hyopthermia occurred). Comorbid conditions included hypothyroidism in six reports, five in patients who received valproic acid concomitantly with topiramate and five reports of hyperammonemia in similarly treated patients. Data mining scores (empirical Bayes geometric mean) for antiepileptic drugs ranged from a high of 5.845 for phenobarbital to 2.956 for gabapentin. Hypothermia was reported 4.7 times more frequently when topiramate was used than was statistically expected.Conclusion:We have found hypothermia, defined as an unintentional drop in body core temperature to <35 degree C, to be associated with concomitant administration of topiramate (a carbonic anhydrase inhibitor) and valproic acid in patients who have tolerated either drug alone. Data mining analysis for topiramate showed a signal of hypothermia. Topiramate was reported 4.72 times more frequently in the database than would be statistically expected when considering all other drugs. Topiramate may act pharmacodynamically to potentiate the effects of valproic acid as a result of its ability to decrease blood HCO3- and increase blood ammonia levels. JF - Journal of Clinical Pharmacy and Therapeutics AU - Knudsen, J F AU - Sokol, G H AU - Flowers, C M AD - *New Hope Cancer Center, Hudson, FL, USA, james.knudsen@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 513 EP - 519 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 33 IS - 5 SN - 0269-4727, 0269-4727 KW - Health & Safety Science Abstracts; Risk Abstracts KW - ammonia KW - bicarbonate KW - GABAA receptor KW - hypothermia KW - topiramate KW - valproic acid KW - USA KW - Age KW - Ammonia KW - Temperature KW - prevention KW - overdose KW - Enzymes KW - Drugs KW - Side effects KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20466398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacy+and+Therapeutics&rft.atitle=Adjunctive+topiramate+enhances+the+risk+of+hypothermia+associated+with+valproic+acid+therapy&rft.au=Knudsen%2C+J+F%3BSokol%2C+G+H%3BFlowers%2C+C+M&rft.aulast=Knudsen&rft.aufirst=J&rft.date=2008-10-01&rft.volume=33&rft.issue=5&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacy+and+Therapeutics&rft.issn=02694727&rft_id=info:doi/10.1111%2Fj.1365-2710.2008.00943.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Ammonia; prevention; Temperature; Enzymes; overdose; Drugs; Side effects; USA DO - http://dx.doi.org/10.1111/j.1365-2710.2008.00943.x ER - TY - JOUR T1 - Surface chemistry reactions of alpha -terpineol [(R)-2-(4-methyl-3-cyclohexenyl)isopropanol] with ozone and air on a glass and a vinyl tile AN - 20442437; 9132180 AB - AbstractThe surface-phase reaction products of alpha -terpineol [(R)-2-(4-methyl-3-cyclohexenyl)isopropanol] with ozone (O3), air or nitrogen (N2) on both a glass and vinyl flooring tile were investigated using the recently published FLEC Automation and Control System (FACS). The FACS was used to deliver O3 (100ppb), air or N2 to the surface at a specified flow rate (300ml/min) and relative humidity (50%) after application of a 1.6% alpha -terpineol solution in methanol. Oxidation products were detected using the derivatization agents: O-(2,3,4,5,6-pentafluorobenzyl) hydroxylamine and N,O-bis(trimethysilyl)trifluoroacetamide. The positively identified reaction products were glyoxal, methylglyoxal and 4-oxopentanal. The proposed oxidation products based on previously published VOC/O3 reaction mechanisms were: 4-methylcyclohex-3-en-1-one, 6-hydroxyhept-en-2-one, 3-(1-hydroxy-1-methylethyl)-6-methylcyclohex-2-en-1-one) and one surface-enhanced reaction product: 5-(1-hydroxy-1-methylethyl)-2-methylcyclohex-2-en-1-one. Though similar products were observed in gas-phase alpha -terpineol/O3 reactions, the ratio of the reaction products were different suggesting stabilization of larger molecular weight species by the surface. Emission profiles of these oxidation products over 72h are also reported. Practical ImplicationsVolatile organic compounds (VOCs) can interact with indoor initiators [such as hydroxyl radicals (OH times ), ozone and nitrate radicals (NO3 times )] to form a number of oxygenated by-products in the gas-phase. However, when VOCs are applied to or are present on the surface, heterogeneous chemistry with indoor initiators can also occur. The surface can influence the reaction mechanism to produce new surface reaction products. The work, described here, shows the interaction of alpha -terpineol (major component of pine oil) with ozone and air on both glass and vinyl flooring. These results demonstrated emissions of oxygenated organic compounds as a result of reaction and that further investigations of this chemistry are required to accurately estimate indoor occupant exposures. JF - Indoor Air AU - Ham, JE AU - Wells, J R AD - Exposure Assessment Branch, Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, WV, USA, bvo2@cdc.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 394 EP - 407 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 18 IS - 5 SN - 0905-6947, 0905-6947 KW - Pollution Abstracts KW - alpha -Terpineol KW - Ozone KW - Reaction products KW - Surface chemistry KW - Nitrates KW - surface chemistry KW - Byproducts KW - Humidity KW - Automation KW - hydroxylamines KW - Flow rates KW - Hydroxyl radicals KW - Oil KW - Control systems KW - Atmospheric chemistry KW - Oxidation KW - Emissions KW - Indoor environments KW - Volatile organic compounds KW - Nitrogen KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20442437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+Air&rft.atitle=Surface+chemistry+reactions+of+alpha+-terpineol+%5B%28R%29-2-%284-methyl-3-cyclohexenyl%29isopropanol%5D+with+ozone+and+air+on+a+glass+and+a+vinyl+tile&rft.au=Ham%2C+JE%3BWells%2C+J+R&rft.aulast=Ham&rft.aufirst=JE&rft.date=2008-10-01&rft.volume=18&rft.issue=5&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Indoor+Air&rft.issn=09056947&rft_id=info:doi/10.1111%2Fj.1600-0668.2008.00540.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nitrates; surface chemistry; Byproducts; Automation; Humidity; hydroxylamines; Flow rates; Hydroxyl radicals; Oil; Control systems; Oxidation; Atmospheric chemistry; Emissions; Indoor environments; Volatile organic compounds; Ozone; Nitrogen DO - http://dx.doi.org/10.1111/j.1600-0668.2008.00540.x ER - TY - JOUR T1 - Tools for evidence-based toxicology: computational-based strategies as a viable modality for decision support in chemical safety evaluation and risk assessment AN - 20320363; 8933921 JF - Human & Experimental Toxicology AU - Valerio, LG Jr AD - Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave, White Oak 51, Room 4218, Silver Spring, Maryland 20993-0002, USA, Luis.Valerio@fda.hhs.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 757 EP - 760 VL - 27 IS - 10 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - Risk assessment KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20320363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Tools+for+evidence-based+toxicology%3A+computational-based+strategies+as+a+viable+modality+for+decision+support+in+chemical+safety+evaluation+and+risk+assessment&rft.au=Valerio%2C+LG+Jr&rft.aulast=Valerio&rft.aufirst=LG&rft.date=2008-10-01&rft.volume=27&rft.issue=10&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/10.1177%2F0960327108097689 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment DO - http://dx.doi.org/10.1177/0960327108097689 ER - TY - JOUR T1 - Production of biologically active CXC chemokines by Lactococcus lactis: Evaluation of its potential as a novel mucosal vaccine adjuvant AN - 20120739; 8618180 AB - Chemokines have been described as essential mediators in leukocytes migration to inflammatory sites and to secondary lymphoid organs. Mig and IP- 10 are two CXC chemokines that recruit mononuclear cells in vivo and inhibit angiogenesis. In addition to their chemotactic roles, Mig and IP-10 have also an important role in the adaptative immune response. In this study, we asked whether a food-grade bacterium, Lactococcus lactis, is able to produce a fusion protein comprising Mig and IP-10 (Mig::IP-10). The activity of the recombinant Mig::IP-10 produced by the genetically engineered L. lactis (LL-Mig::IP-10) was confirmed in a murine spleen cells chemotaxis assay. Moreover, the adjuvant properties of LL-Mig::IP-10 strain were evaluated in mice by the co-expression of a model antigen, the human papillomavirus type 16 E7 protein. Our data show that LL-Mig::IP-10 can produce a genetic fusion of Mig::IP-10 biologically active. This recombinant strain represents a potential candidate for the development of new strategies for mucosal vaccination. JF - Vaccine AU - Cortes-Perez, Naima G AU - Medina, Luis Fda Costa AU - Lefevre, Francois AU - Langella, Philippe AU - Bermudez-Humaran, Luis G AD - INRA 0910, 78352 Jouy-en-Josas, France, luis.bermudez@jouy.inra.fr Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 5778 EP - 5783 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 46 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Chemokines KW - Adjuvant KW - Lactococcus lactis KW - Mig KW - IP-10 KW - Mucosal vaccines KW - HPV-16 KW - E7 KW - Leukocytes (mononuclear) KW - Data processing KW - CXC chemokines KW - Food KW - Mucosa KW - Angiogenesis KW - Animal models KW - Spleen KW - Adjuvants KW - Chemotaxis KW - Vaccination KW - Inflammation KW - Leukocyte migration KW - IP-10 protein KW - Human papillomavirus 16 KW - Genetic engineering KW - E7 protein KW - Vaccines KW - Immune response KW - Fusion protein KW - V 22350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20120739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Production+of+biologically+active+CXC+chemokines+by+Lactococcus+lactis%3A+Evaluation+of+its+potential+as+a+novel+mucosal+vaccine+adjuvant&rft.au=Cortes-Perez%2C+Naima+G%3BMedina%2C+Luis+Fda+Costa%3BLefevre%2C+Francois%3BLangella%2C+Philippe%3BBermudez-Humaran%2C+Luis+G&rft.aulast=Cortes-Perez&rft.aufirst=Naima&rft.date=2008-10-01&rft.volume=26&rft.issue=46&rft.spage=5778&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.08.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Leukocytes (mononuclear); Data processing; CXC chemokines; Food; Mucosa; Animal models; Angiogenesis; Spleen; Adjuvants; Vaccination; Chemotaxis; Inflammation; Leukocyte migration; IP-10 protein; Genetic engineering; E7 protein; Fusion protein; Immune response; Vaccines; Lactococcus lactis; Human papillomavirus 16 DO - http://dx.doi.org/10.1016/j.vaccine.2008.08.044 ER - TY - JOUR T1 - Defining 'Neuroinflammation' AN - 19761861; 8647702 AB - Neuroinflammation is a hot topic in contemporary neuroscience. A relatively new open-access journal, the Journal of Neuroinflammation, focuses on this field. As another example, abstracts to the 2007 Annual Meeting of the Society for Neuroscience could be submitted in several subcategories of neuroinflammation, a strong signal of growth in this research area. While it is becoming clear that activation of microglia and astroglia and the attendant expression of proinflammatory cytokines and chemokines often are associated with disease-, trauma-, and toxicant-induced damage to the CNS, it is by no means clear that a cause-and-effect relationship exists between the presence of a neuroinflammatory process and neural damage. We have explored this issue with two models of dopaminergic neurotoxicity. We used a single low-dose regimen of MPTP or METH, a paradigm that causes selective degeneration of striatal dopaminergic nerve terminals without affecting the cell body in the substantia nigra. Both compounds increased the expression of the microglia-associated factors, Il-1 alpha , Il6, Ccl2, and Tnf- alpha , and also elicited morphologic evidence of microglial activation prior to induction of astrogliosis. Pharmacologic antagonism of MPTP and METH neurotoxicity prevented these proinflammatory responses, findings suggestive of a link between neuroinflammation and the observed neurotoxic outcomes. Nevertheless, when we used minocycline to suppress the expression of all these mediators, with the exception of Tnf- alpha , we failed to see neuroprotection. Likewise, when we examined the effects of MPTP or METH in transgenic mice lacking Il6, Ccl2, or Tnfr1-2 genes, deficiency of either Il6 or Ccl2 did not alter neurotoxicity, whereas deficiency in Tnfr1-2 was neuroprotective. Although these observations pointed to a role of the proinflammatory cytokine, TNF- alpha , in the neurotoxic effects of MPTP and METH, other observations did not support this supposition. For example, activation of NF- Kappa B or induction of iNOS, known components of inflammatory responses and free radical formation, were not observed. Moreover, immunosuppressive regimens of glucocorticoids failed to suppress TNF- alpha or attenuate neurotoxicity. Taken together, our observations suggest that MPTP and METH neurotoxicity are associated with the elaboration of a 'neuroinflammatory' response, yet this response lacks key features of inflammation and, with the exception of TNF- alpha , neurotoxicity appears to be the cause rather than the consequence of proinflammatory signals. JF - Annals of the New York Academy of Sciences AU - O'Callaghan, James P AU - Sriram, Krishnan AU - Miller, Diane B AD - Centers for Disease Control and Prevention-NIOSH Morgantown, West Virginia, USA, jdo5@cdc.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 318 EP - 330 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1139 IS - 1 SN - 0077-8923, 0077-8923 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - neuroinflammation KW - neurotoxicity KW - methamphetamine KW - MPTP KW - gliosis KW - microglia KW - astroglia KW - cytokines KW - chemokines KW - dopamine KW - dopaminergic KW - Interleukin 6 KW - Central nervous system KW - Minocycline KW - Chemokines KW - Astrocytes KW - Interleukin 1 KW - Animal models KW - Neuroprotection KW - Immunosuppressive agents KW - Neurodegeneration KW - NF- Kappa B protein KW - Nerve endings KW - Dopamine KW - Neostriatum KW - Cytokines KW - Substantia nigra KW - Monocyte chemoattractant protein 1 KW - Free radicals KW - Antagonism KW - Transgenic mice KW - Microglia KW - Glucocorticoids KW - Inflammation KW - Nitric-oxide synthase KW - Neurotoxicity KW - Cell body KW - Gliosis KW - Tumor necrosis factor- alpha KW - W 30910:Imaging KW - F 06910:Microorganisms & Parasites KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19761861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Defining+%27Neuroinflammation%27&rft.au=O%27Callaghan%2C+James+P%3BSriram%2C+Krishnan%3BMiller%2C+Diane+B&rft.aulast=O%27Callaghan&rft.aufirst=James&rft.date=2008-10-01&rft.volume=1139&rft.issue=1&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1432.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Central nervous system; Chemokines; Minocycline; Astrocytes; Interleukin 1; Animal models; Neuroprotection; Neurodegeneration; Immunosuppressive agents; NF- Kappa B protein; Dopamine; Nerve endings; Neostriatum; Cytokines; Substantia nigra; Monocyte chemoattractant protein 1; MPTP; Free radicals; Antagonism; Microglia; Transgenic mice; Glucocorticoids; Inflammation; Nitric-oxide synthase; Cell body; Neurotoxicity; Gliosis; Tumor necrosis factor- alpha DO - http://dx.doi.org/10.1196/annals.1432.032 ER - TY - JOUR T1 - Using mass media campaigns to promote voluntary counseling and HIV-testing services in Kenya AN - 19748945; 8612997 AB - Background: Kenya, a country with high HIV prevalence, has seen a rapid scale-up of voluntary counseling and HIV-testing (VCT) services from three sites in 2000 to 585 by June 2005. From 2002 onwards, services were promoted by a four-phase professionally designed mass media campaign. Objective: To assess the impact of a mass media campaign on VCT services. Design: Observational data from client records. Methods: VCT client data from 131 voluntary counseling and testing sites were included. Descriptive statistics and Poisson regression were used to assess the impact of campaign phases. Results: Client records (381 160) from 131 sites were analyzed. A linear increase in new sites and an exponential increase in client utilization were observed. Regression analysis revealed that the first phase of the campaign increased attendance by 28.5% (95% confidence interval = 15.9, 42.5%) and the fourth by 42.5% (95% confidence interval = 28.4, 64.1%). These two phases, which directly mentioned HIV, had more impact on utilization than the second and third phases, which did not have a significant effect. Conclusion: The Kenyan experience suggests that a professional, intensive mass media campaign is likely to contribute to increases in utilization of testing. Expansion of programs for counseling and HIV testing in developing countries is likely to be facilitated by mass media promotion of these services. JF - AIDS AU - Marum, E AU - Morgan, G AU - Hightower, A AU - Ngare, C AU - Taegtmeyer, M AD - US Department of Health and Human Services/Centers for Disease Control and Prevention, National Center for HIV, STD, and TB Prevention, 1600 Clifton Road MS E-04, Atlanta, GA 30333, USA, emarum@cdc.gov Y1 - 2008/10/01/ PY - 2008 DA - 2008 Oct 01 SP - 2019 EP - 2024 VL - 22 IS - 15 SN - 0269-9370, 0269-9370 KW - Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - Acquired immune deficiency syndrome KW - Kenya KW - Data processing KW - Human immunodeficiency virus KW - mass media KW - Regression analysis KW - Statistical analysis KW - Developing countries KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19748945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Using+mass+media+campaigns+to+promote+voluntary+counseling+and+HIV-testing+services+in+Kenya&rft.au=Marum%2C+E%3BMorgan%2C+G%3BHightower%2C+A%3BNgare%2C+C%3BTaegtmeyer%2C+M&rft.aulast=Marum&rft.aufirst=E&rft.date=2008-10-01&rft.volume=22&rft.issue=15&rft.spage=2019&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e3283104066 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Statistical analysis; Regression analysis; Developing countries; Acquired immune deficiency syndrome; mass media; Human immunodeficiency virus; Kenya DO - http://dx.doi.org/10.1097/QAD.0b013e3283104066 ER - TY - JOUR T1 - Expectations Training for Miners Using Self-Contained Self-Rescuers in Escapes from Underground Coal Mines AN - 19602515; 8502108 AB - National Institute for Occupational Safety and Health researchers conducted a study to investigate the human response issues related to wearing a self-contained self-rescuer (SCSR). The goal was to develop training to educate miners on what they could expect from their units during an escape. Subjects included miners who had experience wearing SCSRs, manufacturers, and researchers. Results identified nine key areas of concern: (1) starting the unit, (2) unit heat, (3) induction of coughing, (4) unit taste, (5) difficulty in breathing while wearing the unit, (6) quality of the air supplied, (7) nose clips, (8) goggles, and (9) the behavior of the breathing bag. In addition, researchers reviewed the literature on human response under duress. This article describes the expectations training program, which comprises the findings of the SCSR study and what is known about the normal human response in an emergency. The authors present background on SCSRs and the SCSR switchover procedure mandated in the recent federal Mine Improvement and New Emergency Response Act of 2006, which provided the impetus for the expectations training. JF - Journal of Occupational and Environmental Hygiene AU - Kowalski-Trakofler, Kathleen M AU - Vaught, Charles AU - Brnich Jr, Michael J AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 671 EP - 677 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 10 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts KW - Training KW - Emergency preparedness KW - Reviews KW - Occupational safety KW - Coal KW - Mines KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Expectations+Training+for+Miners+Using+Self-Contained+Self-Rescuers+in+Escapes+from+Underground+Coal+Mines&rft.au=Kowalski-Trakofler%2C+Kathleen+M%3BVaught%2C+Charles%3BBrnich+Jr%2C+Michael+J&rft.aulast=Kowalski-Trakofler&rft.aufirst=Kathleen&rft.date=2008-10-01&rft.volume=5&rft.issue=10&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802333632 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Training; Reviews; Emergency preparedness; Occupational safety; Coal; Mines DO - http://dx.doi.org/10.1080/15459620802333632 ER - TY - JOUR T1 - Correlation Between Respirator Fit and Respirator Fit Test Panel Cells by Respirator Size AN - 19602410; 8502102 AB - The National Institute for Occupational Safety and Health (NIOSH), recognizing the difficulties inherent in using old military data to define modern industrial respirator fit test panels, recently completed a study to develop an anthropometric database of the measurements of heads and faces of civilian respirator users. Based on the data collected, NIOSH researchers developed two new panels for fit testing half-facepiece and full-facepiece respirators. One of the new panels (NIOSH bivariate panel) uses face length and face width. The other panel is based on principal component analysis (PCA) to identify the linear combination of facial dimensions that best explains facial variations. The objective of this study was to investigate the correlation between respirator fit and the new NIOSH respirator fit test panel cells for various respirator sizes. This study was carried out on 30 subjects that were selected in part using the new NIOSH bivariate panel. Fit tests were conducted on the test subjects using a PORTACOUNT device and three exercises. Each subject was tested with three replications of four models of P-100 half-facepiece respirators in three sizes. This study found that respirator size significantly influenced fit within a given panel cell. Face size categories also matched the respirator sizing reasonably well, in that the small, medium, and large face size categories achieved the highest geometric mean fit factors in the small, medium, and large respirator sizes, respectively. The same pattern holds for fit test passing rate. Therefore, a correlation was found between respirator fit and the new NIOSH bivariate fit test panel cells for various respirator sizes. Face sizes classified by the PCA panel also followed a similar pattern with respirator fit although not quite as consistently. For the LANL panel, however, both small and medium faces achieved best fit in small size respirators, and large faces achieved best fit in medium respirators. These findings support the selection of the facial dimensions for developing the new NIOSH bivariate respirator fit test panel. JF - Journal of Occupational and Environmental Hygiene AU - Zhuang, Ziqing AU - Groce, Dennis AU - Ahlers, Heinz W AU - Iskander, Wafik AU - Landsittel, Douglas AU - Guffey, Steve AU - Benson, Stacey AU - Viscusi, Dennis AU - Shaffer, Ronald E AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 617 EP - 628 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 10 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - principal components analysis KW - Principal components analysis KW - Occupational safety KW - Respirators KW - Military KW - Protective equipment KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Correlation+Between+Respirator+Fit+and+Respirator+Fit+Test+Panel+Cells+by+Respirator+Size&rft.au=Zhuang%2C+Ziqing%3BGroce%2C+Dennis%3BAhlers%2C+Heinz+W%3BIskander%2C+Wafik%3BLandsittel%2C+Douglas%3BGuffey%2C+Steve%3BBenson%2C+Stacey%3BViscusi%2C+Dennis%3BShaffer%2C+Ronald+E&rft.aulast=Zhuang&rft.aufirst=Ziqing&rft.date=2008-10-01&rft.volume=5&rft.issue=10&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802293810 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - principal components analysis; Principal components analysis; Occupational safety; Military; Respirators; Protective equipment DO - http://dx.doi.org/10.1080/15459620802293810 ER - TY - JOUR T1 - Effects of dietary vitamin E, C and soybean oil supplementation on antioxidant enzyme activities in liver and muscles of rats AN - 19582491; 8565421 AB - The effect of elevated levels of dietary vitamin E, C and a combination of vitamin E and C (E&C) with soybean oil on activities of antioxidant (AOE) enzymes important in the protection against lipid peroxidation was studied in male rats fed with vitamin C (12mg/g), vitamin E (3.68mg/g) or E&C (3.68mg/kg+12mg/g) supplemented diets for 28 days. Catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activity in liver, pectoralis major (PM) and sartorius (S) muscles was increased significantly in rats fed with dietary vitamin C, E separately, and vitamin C&E combination, except, superoxide dismutase (SOD), which showed no alterations. These results clearly indicated that vitamin E&C separately and E&C together increased AOE activity in liver, PM and S muscle of rats. However, vitamin E and C combination enhanced AOE activity more significantly and our findings suggest the possible role of vitamin C&E and their combination in reducing the risk of chronic diseases related to oxidative stress. JF - Food and Chemical Toxicology AU - Shireen, K F AU - Pace, R D AU - Mahboob, M AU - Khan, A T AD - Tuskegee University, Tuskegee, Alabama, USA, Kshireen@cfsan.fda.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 3290 EP - 3294 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 10 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Diets KW - glutathione reductase KW - Antioxidants KW - Muscles KW - Enzymes KW - Catalase KW - Lipid peroxidation KW - Ascorbic acid KW - Soybeans KW - Oil KW - Vitamin E KW - Glutathione peroxidase KW - Superoxide dismutase KW - Oxidative stress KW - Dietary supplements KW - Liver KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19582491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+dietary+vitamin+E%2C+C+and+soybean+oil+supplementation+on+antioxidant+enzyme+activities+in+liver+and+muscles+of+rats&rft.au=Shireen%2C+K+F%3BPace%2C+R+D%3BMahboob%2C+M%3BKhan%2C+A+T&rft.aulast=Shireen&rft.aufirst=K&rft.date=2008-10-01&rft.volume=46&rft.issue=10&rft.spage=3290&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2008.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - glutathione reductase; Diets; Antioxidants; Muscles; Enzymes; Lipid peroxidation; Catalase; Soybeans; Ascorbic acid; Oil; Vitamin E; Oxidative stress; Superoxide dismutase; Glutathione peroxidase; Dietary supplements; Liver DO - http://dx.doi.org/10.1016/j.fct.2008.07.015 ER - TY - JOUR T1 - Jarring/jolting exposure and musculoskeletal symptoms among farm equipment operators AN - 19581967; 8549520 AB - Vehicle vibration exposure has been linked to chronic back pain and low-back symptoms among agricultural tractor drivers. The objectives of this study by the National Institute for Occupational Safety and Health (NIOSH) were to assess driver whole-body vibration (WBV) exposures and recommend interventions to reduce the risk of back-related injuries, particularly relative to vehicle jarring/jolting (the transient mechanical shock components of WBV). The methodology included collecting, from two independent samples, field data and health and work history data of farm equipment operators. Data were collected during mowing, raking, baling, chiseling, tilling, and road travel for different model tractors. Spraying using a sprayer and shrub removal with a skid-steer loader were also included. Based on ISO 2631 (1985), the American Conference of Governmental Industrial Hygienists, threshold limit values, presents 0.5 m/s2 as the action level recommended by the Commission of European Communities for overall weighted total RMS acceleration (vector sum for axes x, y, and z) [ACGIH, 2006. Threshold limit values and biological exposure indices. Cincinnati, OH]. WBV measured at the operator/seat interface exceeded this action level. The roughest rides and highest vector sum accelerations occurred with small utility tractor mowers (3.3 and 2.8 m/s2) and a skid-steer loader (1.7 m/s2). Major findings from health and work history data showed 96% of participants reported having to bend or twist their necks, although 24% reported neck symptoms. Sixty-four percent of participating operators reported experiencing back symptoms (e.g., pain, aching, stiffness, etc.). Recommendations included: specifying a seat that 'better' isolates operators from jars/jolts with new tractor purchases; maintaining the seat/seat suspension and replacing worn or damaged cushions with NIOSH tested viscoelastic foam padding; using larger diameter tires with radial-ply instead of bias-ply construction, particularly on small utility tractor-mowers, to aid in attenuating ride 'roughness'; using a swivel seat to reduce the stress on the neck from bending or twisting; and improving efforts to educate owner/operators of the adverse effects of WBV exposures. Since the data presented in this paper were collected from two independent samples, the authors were unable to draw any correlations or etiological inferences from the study. However, results were compared and contrasted with other studies which included similar vibration measurements in agriculture. Relevance to industry Studies concerning agricultural tractor drivers have shown that vibration exposure and duration of exposure are associated with lifetime, transient, and chronic back pain and low-back symptoms. The results from the field measurements and health and work history data are useful for the U.S. agricultural industry to help reduce back injury risk for farm equipment operators. JF - International Journal of Industrial Ergonomics AU - Mayton, A G AU - Kittusamy, N K AU - Ambrose, D H AU - Jobes, C C AU - Legault, M L AD - NIOSH, Pittsburgh, PA, USA, amayton@cdc.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 758 EP - 766 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 38 IS - 9-10 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Injuries KW - risk reduction KW - USA, Ohio, Cincinnati KW - agriculture KW - Stress KW - back pain KW - Tires KW - Occupational safety KW - Threshold limits KW - intervention KW - farms KW - Occupational exposure KW - Ergonomics KW - Vibration KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19581967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Jarring%2Fjolting+exposure+and+musculoskeletal+symptoms+among+farm+equipment+operators&rft.au=Mayton%2C+A+G%3BKittusamy%2C+N+K%3BAmbrose%2C+D+H%3BJobes%2C+C+C%3BLegault%2C+M+L&rft.aulast=Mayton&rft.aufirst=A&rft.date=2008-10-01&rft.volume=38&rft.issue=9-10&rft.spage=758&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2007.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Ohio, Cincinnati; Vibration; Ergonomics; Occupational exposure; farms; Historical account; Threshold limits; Injuries; back pain; Stress; Occupational safety; risk reduction; agriculture; Tires; intervention DO - http://dx.doi.org/10.1016/j.ergon.2007.10.011 ER - TY - JOUR T1 - Differential Sorting of Human Parathyroid Hormone After Transduction of Mouse and Rat Salivary Glands AN - 19410054; 8759280 AB - Gene transfer to salivary glands leads to abundant secretion of transgenic protein into either saliva or the bloodstream. This indicates significant clinical potential, depending on the route of sorting. The aim of this study was to probe the sorting characteristics of human parathyroid hormone (hPTH) in two animal models for salivary gland gene transfer. PTH is a key hormone regulating calcium levels in the blood. A recombinant serotype 5 adenoviral vector carrying the hPTH cDNA was administered to the submandibular glands of mice and rats. Two days after delivery, high levels of hPTH were found in the serum of mice, leading to elevated serum calcium levels. Only low amounts of hPTH were found in the saliva. Two days after vector infusion into rats, a massive secretion of hPTH was measured in saliva, with little secretion into serum. Confocal microscopy showed hPTH in the glands, localized basolaterally in mice and apically in rats. Submandibular gland transduction was effective and the produced hPTH was biologically active in vivo. Whereas hPTH sorted toward the basolateral side in mice, in rats hPTH was secreted mainly at the apical side. These results indicate that the interaction between hPTH and the cell sorting machinery is different between mouse and rat salivary glands. Detailed studies in these two species should result in a better understanding of cellular control of transgenic secretory protein sorting in this tissue. JF - Human Gene Therapy AU - Adriaansen, J AU - Perez, P AU - Goldsmith, C M AU - Zheng, C AU - Baum, B J AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Building 10, Room 1N113, MSC-1190, 10 Center Drive, Bethesda, MD 20892-1190, USA, adriaansenj@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1021 EP - 1028 VL - 19 IS - 10 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Protein transport KW - Calcium KW - Serotypes KW - Gene therapy KW - Secretion KW - Animal models KW - Probes KW - Salivary gland KW - Hormones KW - Calcium (blood) KW - Expression vectors KW - Blood KW - Confocal microscopy KW - Parathyroid hormone KW - Submandibular gland KW - Saliva KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19410054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Differential+Sorting+of+Human+Parathyroid+Hormone+After+Transduction+of+Mouse+and+Rat+Salivary+Glands&rft.au=Adriaansen%2C+J%3BPerez%2C+P%3BGoldsmith%2C+C+M%3BZheng%2C+C%3BBaum%2C+B+J&rft.aulast=Adriaansen&rft.aufirst=J&rft.date=2008-10-01&rft.volume=19&rft.issue=10&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2008.079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein transport; Serotypes; Calcium; Gene therapy; Secretion; Probes; Animal models; Salivary gland; Calcium (blood); Hormones; Expression vectors; Blood; Confocal microscopy; Parathyroid hormone; Submandibular gland; Saliva DO - http://dx.doi.org/10.1089/hum.2008.079 ER - TY - RPRT T1 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. [Part 1 of 2] T2 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. AN - 756825135; 13624-080398_0001 AB - PURPOSE: The adoption of an updated master development plan for the Rocky Mountain Laboratories (RML) campus of the National Institutes of Health (NIH) Main Campus in Hamilton, Ravalli County, Montana is proposed. The primary mission of NIH is to expand fundamental knowledge about the nature and behavior or living systems, to apply that knowledge to enhance the health of humans, and to reduce the burdens of disease and disability. If adopted, the proposed 20-year master plan, which would be reviewed quinquennially, would constitute part of a broad, long-term planning effort at the Department of Health and Human Services (HHS) and would fulfill a requirement of all HHS-administered campuses. The plan would provide a strategy for accommodating potential RML campus development subject to NIH and HHS priorities and the availability of resources. It also would serve as a guide for the development of individual projects, and assist local jurisdictions and utilities in anticipating and planning for infrastructure and systems as they relate to the needs of the RML. It would guide and coordinate the physical development of the RML campus with respect to siting of future construction, vehicular and pedestrian circulation on and off-campus, parking within the property boundaries, open space in and around the campus, required setbacks, historic properties management, natural and scenic resources, and noise and lighting; these considerations would respond to projected NIH administrative, research, and infrastructure support needs. Programming of future campus personnel and facilities was determined through an extensive series of interviews with NIH management and individual institute and center directorates. Three alternatives, including a No Action Alternative, which would retain the existing master plan and complete ongoing projects, are considered in this draft EIS. The proposed Alternative would expand the campus from 33 acres to 36 acres, expand the extent of developed areas from nine acres to 17 acres, and expand the occupiable building area from 323,805 gross square feet to 445,713 gross square feet. The principal features of the master plan would provide for campus upgrades, such as the demolition and replacement of obsolete buildings; construction of a central administration and storage building, which would represent much of the building area growth; expansion of parking facilities from a capacity of 400 spaces to a capacity of 461 spaces; modification of the Fifth Street access point; construction of a new long-term storage facility; installation of a new expanded perimeter fence; creation of a pedestrian core at the center of campus; and provision of landscaped open space throughout campus. POSITIVE IMPACTS: Plan implementation would significantly enhance the functional and social aspects of the NIH Bethesda Campus. Research facilities would be significantly upgraded and facility inadequacies would be corrected. The modified transportation system would provide enhance access within the campus, and landscaping and other aesthetic improvements would transform the somewhat dysfunctional campus into a pleasing and functionally adequate workplace. Utility line conflicts would be resolved. NEGATIVE IMPACTS: The extent of open, undisturbed area would decline from 24 acres to 19 acres. Increases in personnel using the site would place additional stress on the local transportation system within and outside the campus, utilities and waste management facilities, and energy sources. Construction activities, demolition of historically significant buildings, and new buildings and infrastructure would alter the visual appearance of the RML Historic District. JF - EPA number: 080398, Draft EIS--73 pages, Draft Master Plan--102 pages, September 26, 2008 PY - 2008 VL - 1 KW - Urban and Social Programs KW - Buildings KW - Demolition KW - Employment KW - Historic Districts KW - Historic Sites KW - Open Space KW - Parking KW - Research Facilities KW - Roads KW - Site Planning KW - Storage KW - Transportation KW - Vegetation KW - Visual Resources KW - Montana UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756825135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=Peter&rft.date=1981-09-14&rft.volume=128&rft.issue=6&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Forbes&rft.issn=00156914&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2008-12-30 N1 - SuppNotes - Draft. Preparation date: September 26, 2008 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. [Part 2 of 2] T2 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. AN - 756824817; 13624-080398_0002 AB - PURPOSE: The adoption of an updated master development plan for the Rocky Mountain Laboratories (RML) campus of the National Institutes of Health (NIH) Main Campus in Hamilton, Ravalli County, Montana is proposed. The primary mission of NIH is to expand fundamental knowledge about the nature and behavior or living systems, to apply that knowledge to enhance the health of humans, and to reduce the burdens of disease and disability. If adopted, the proposed 20-year master plan, which would be reviewed quinquennially, would constitute part of a broad, long-term planning effort at the Department of Health and Human Services (HHS) and would fulfill a requirement of all HHS-administered campuses. The plan would provide a strategy for accommodating potential RML campus development subject to NIH and HHS priorities and the availability of resources. It also would serve as a guide for the development of individual projects, and assist local jurisdictions and utilities in anticipating and planning for infrastructure and systems as they relate to the needs of the RML. It would guide and coordinate the physical development of the RML campus with respect to siting of future construction, vehicular and pedestrian circulation on and off-campus, parking within the property boundaries, open space in and around the campus, required setbacks, historic properties management, natural and scenic resources, and noise and lighting; these considerations would respond to projected NIH administrative, research, and infrastructure support needs. Programming of future campus personnel and facilities was determined through an extensive series of interviews with NIH management and individual institute and center directorates. Three alternatives, including a No Action Alternative, which would retain the existing master plan and complete ongoing projects, are considered in this draft EIS. The proposed Alternative would expand the campus from 33 acres to 36 acres, expand the extent of developed areas from nine acres to 17 acres, and expand the occupiable building area from 323,805 gross square feet to 445,713 gross square feet. The principal features of the master plan would provide for campus upgrades, such as the demolition and replacement of obsolete buildings; construction of a central administration and storage building, which would represent much of the building area growth; expansion of parking facilities from a capacity of 400 spaces to a capacity of 461 spaces; modification of the Fifth Street access point; construction of a new long-term storage facility; installation of a new expanded perimeter fence; creation of a pedestrian core at the center of campus; and provision of landscaped open space throughout campus. POSITIVE IMPACTS: Plan implementation would significantly enhance the functional and social aspects of the NIH Bethesda Campus. Research facilities would be significantly upgraded and facility inadequacies would be corrected. The modified transportation system would provide enhance access within the campus, and landscaping and other aesthetic improvements would transform the somewhat dysfunctional campus into a pleasing and functionally adequate workplace. Utility line conflicts would be resolved. NEGATIVE IMPACTS: The extent of open, undisturbed area would decline from 24 acres to 19 acres. Increases in personnel using the site would place additional stress on the local transportation system within and outside the campus, utilities and waste management facilities, and energy sources. Construction activities, demolition of historically significant buildings, and new buildings and infrastructure would alter the visual appearance of the RML Historic District. JF - EPA number: 080398, Draft EIS--73 pages, Draft Master Plan--102 pages, September 26, 2008 PY - 2008 VL - 2 KW - Urban and Social Programs KW - Buildings KW - Demolition KW - Employment KW - Historic Districts KW - Historic Sites KW - Open Space KW - Parking KW - Research Facilities KW - Roads KW - Site Planning KW - Storage KW - Transportation KW - Vegetation KW - Visual Resources KW - Montana UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756824817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1991-09-01&rft.volume=66&rft.issue=262&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Thought&rft.issn=00406457&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2008-12-30 N1 - SuppNotes - Draft. Preparation date: September 26, 2008 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay. AN - 69643784; 18822145 AB - The emergence of influenza strains that are resistant to commonly used antivirals has highlighted the need to develop new compounds that target viral gene products or host mechanisms that are essential for effective virus replication. Existing assays to identify potential antiviral compounds often use high throughput screening assays that target specific viral replication steps. To broaden the search for antivirals, cell-based replication assays can be performed, but these are often labor intensive and have limited throughput. We have adapted a traditional virus neutralization assay to develop a practical, cell-based, high throughput screening assay. This assay uses viral neuraminidase (NA) as a read-out to quantify influenza replication, thereby offering an assay that is both rapid and sensitive. In addition to identification of inhibitors that target either viral or host factors, the assay allows simultaneous evaluation of drug toxicity. Antiviral activity was demonstrated for a number of known influenza inhibitors including amantadine that targets the M2 ion channel, zanamivir that targets NA, ribavirin that targets IMP dehydrogenase, and bis-indolyl maleimide that targets protein kinase A/C. Amantadine-resistant strains were identified by comparing IC50 with that of the wild-type virus. Antivirals with specificity for a broad range of targets are easily identified in an accelerated viral inhibition assay that uses NA as a read-out of replication. This assay is suitable for high throughput screening to identify potential antivirals or can be used to identify drug-resistant influenza strains. JF - Virology journal AU - Eichelberger, Maryna C AU - Hassantoufighi, Arash AU - Wu, Meng AU - Li, Min AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA. Maryna.Eichelberger@fda.hhs.gov Y1 - 2008/09/26/ PY - 2008 DA - 2008 Sep 26 SP - 109 VL - 5 KW - Antiviral Agents KW - 0 KW - Enzyme Inhibitors KW - Viral Proteins KW - Neuraminidase KW - EC 3.2.1.18 KW - Index Medicus KW - Animals KW - Drug Resistance, Viral KW - Ducks KW - Virus Replication -- drug effects KW - Humans KW - Chick Embryo KW - Drug Evaluation, Preclinical KW - Viral Proteins -- genetics KW - Influenza B virus -- enzymology KW - Neuraminidase -- antagonists & inhibitors KW - Neuraminidase -- genetics KW - Influenza, Human -- virology KW - Influenza A virus -- drug effects KW - Influenza A virus -- enzymology KW - Influenza B virus -- drug effects KW - Antiviral Agents -- pharmacology KW - Neuraminidase -- metabolism KW - Viral Proteins -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Viral Proteins -- antagonists & inhibitors KW - Influenza, Human -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69643784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology+journal&rft.atitle=Neuraminidase+activity+provides+a+practical+read-out+for+a+high+throughput+influenza+antiviral+screening+assay.&rft.au=Litzinger%2C+William+D%3BSchaefer%2C+Thomas+E&rft.aulast=Litzinger&rft.aufirst=William&rft.date=1987-03-01&rft.volume=30&rft.issue=2&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Business+Horizons&rft.issn=00076813&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-06 N1 - Date created - 2008-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antiviral Res. 2007 Mar;73(3):228-31 [17112602] Pediatrics. 2006 Sep;118(3):e579-85 [16950949] Cell Physiol Biochem. 2007;20(1-4):75-82 [17595517] Int J Geriatr Psychiatry. 2007 Sep;22(9):935-6 [17721896] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18235-40 [17991777] Curr Pharm Des. 2007;13(34):3531-42 [18220789] Emerg Infect Dis. 2007 Sep;13(9):1354-7 [18252107] PLoS Pathog. 2008 Jul;4(7):e1000103 [18654625] Antiviral Res. 2002 Jan;53(1):47-61 [11684315] Antimicrob Agents Chemother. 2000 Apr;44(4):859-66 [10722482] Antimicrob Agents Chemother. 2008 Sep;52(9):3284-92 [18625765] J Virol Methods. 2004 Dec 1;122(1):9-15 [15488615] Science. 1972 Aug 25;177(4050):705-6 [4340949] Appl Microbiol. 1973 Feb;25(2):195-201 [4121031] Virology. 1974 Oct;61(2):397-410 [4472498] Anal Biochem. 1979 Apr 15;94(2):287-96 [464297] Pharmacol Ther. 1979;6(1):123-46 [390559] Cell. 1992 May 1;69(3):517-28 [1374685] Nature. 1993 Jun 3;363(6428):418-23 [8502295] Clin Diagn Lab Immunol. 1996 Sep;3(5):507-10 [8877126] Antiviral Res. 2005 Oct;68(1):10-7 [16087250] J Gen Virol. 2005 Oct;86(Pt 10):2823-30 [16186238] Lancet. 2005 Oct 1;366(9492):1175-81 [16198766] Emerg Infect Dis. 2005 Sep;11(9):1355-62 [16229762] Cell Microbiol. 2006 Mar;8(3):375-86 [16469051] Emerg Infect Dis. 2006 Jan;12(1):9-14 [16494710] Pediatr Infect Dis J. 2006 Jun;25(6):572 [16732168] J Biol Chem. 2006 Jun 16;281(24):16707-15 [16608852] J Infect Dis. 2007 Jul 15;196(2):249-57 [17570112] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1743-422X-5-109 ER - TY - JOUR T1 - Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. AN - 69461467; 18639561 AB - Genomic hypomethylation is a consistent finding in both human and animal tumors and mounting experimental evidence suggests a key role for epigenetic events in tumorigenesis. Furthermore, it has been suggested that early changes in DNA methylation and histone modifications may serve as sensitive predictive markers in animal testing for carcinogenic potency of environmental agents. Alterations in metabolism of methyl donors, disturbances in activity and/or expression of DNA methyltransferases, and presence of DNA single-strand breaks could contribute to the loss of cytosine methylation during carcinogenesis; however, the precise mechanisms of genomic hypomethylation induced by chemical carcinogens remain largely unknown. This study examined the mechanism of DNA hypomethylation during hepatocarcinogenesis induced by peroxisome proliferators WY-14,643 (4-chloro-6-(2,3-xylidino)-pyrimidynylthioacetic acid) and DEHP (di-(2-ethylhexyl)phthalate), agents acting through non-genotoxic mode of action. In the liver of male Fisher 344 rats exposed to WY-14,643 (0.1% (w/w), 5 months), the level of genomic hypomethylation increased by approximately 2-fold, as compared to age-matched controls, while in the DEHP group (1.2% (w/w), 5 months) DNA methylation did not change. Global DNA hypomethylation in livers from WY-14,643 group was accompanied by the accumulation of DNA single-strand breaks, increased cell proliferation, and diminished expression of DNA methyltransferase 1, while the metabolism of methyl donors was not affected. In contrast, none of these parameters changed significantly in rats fed DEHP. Since WY-14,643 is much more potent carcinogen than DEHP, we conclude that the extent of loss of DNA methylation may be related to the carcinogenic potential of the chemical agent, and that accumulation of DNA single-strand breaks coupled to the increase in cell proliferation and altered DNA methyltransferase expression may explain genomic hypomethylation during peroxisome proliferator-induced carcinogenesis. JF - Mutation research AU - Pogribny, Igor P AU - Tryndyak, Volodymyr P AU - Boureiko, Anna AU - Melnyk, Stepan AU - Bagnyukova, Tetyana V AU - Montgomery, Beverly AU - Rusyn, Ivan AD - Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. igor.pogribny@fda.hhs.gov Y1 - 2008/09/26/ PY - 2008 DA - 2008 Sep 26 SP - 17 EP - 23 VL - 644 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Histones KW - 0 KW - Mutagens KW - Peroxisome Proliferators KW - Proliferating Cell Nuclear Antigen KW - Pyrimidines KW - pirinixic acid KW - 86C4MRT55A KW - Diethylhexyl Phthalate KW - C42K0PH13C KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - DNA (cytosine-5-)-methyltransferase 1 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Diethylhexyl Phthalate -- toxicity KW - Histones -- chemistry KW - Mutagens -- toxicity KW - DNA (Cytosine-5-)-Methyltransferase -- metabolism KW - DNA Breaks, Single-Stranded KW - Rats KW - Rats, Inbred F344 KW - Histones -- metabolism KW - Pyrimidines -- toxicity KW - Methylation KW - Male KW - Proliferating Cell Nuclear Antigen -- metabolism KW - Liver -- drug effects KW - Peroxisome Proliferators -- toxicity KW - DNA Methylation -- drug effects KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69461467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Mechanisms+of+peroxisome+proliferator-induced+DNA+hypomethylation+in+rat+liver.&rft.au=Pogribny%2C+Igor+P%3BTryndyak%2C+Volodymyr+P%3BBoureiko%2C+Anna%3BMelnyk%2C+Stepan%3BBagnyukova%2C+Tetyana+V%3BMontgomery%2C+Beverly%3BRusyn%2C+Ivan&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2008-09-26&rft.volume=644&rft.issue=1-2&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrfmmm.2008.06.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-12 N1 - Date created - 2008-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Pharmacol Toxicol. 2002;42:501-25 [11807181] Toxicology. 2008 Apr 3;246(1):2-8 [18006136] Toxicol Sci. 2003 Oct;75(2):229-35 [12773759] Toxicol Sci. 2003 Oct;75(2):289-99 [12883089] J Nutr. 2003 Nov;133(11 Suppl 1):3740S-3747S [14608108] Cancer Sci. 2004 Jan;95(1):58-64 [14720328] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] Nat Rev Cancer. 2004 Feb;4(2):143-53 [14732866] Cancer Res. 2004 Feb 1;64(3):1050-7 [14871837] Science. 2004 Mar 12;303(5664):1626-32 [15016989] Toxicol Appl Pharmacol. 2004 May 1;196(3):422-30 [15094313] Life Sci. 1976 May 1;18(9):941-5 [1271963] Cancer Res. 1988 Dec 1;48(23):6739-44 [3180084] Carcinogenesis. 1993 Dec;14(12):2495-9 [8269617] DNA Cell Biol. 1996 Mar;15(3):255-62 [8634154] Mutat Res. 1997 Apr;386(2):141-52 [9113115] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10907-12 [9380733] Carcinogenesis. 1998 Aug;19(8):1487-94 [9744547] Biochem Biophys Res Commun. 1999 Sep 7;262(3):624-8 [10471374] Toxicol Sci. 2005 Oct;87(2):344-52 [16014735] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13580-5 [16174748] EXS. 2006;(96):321-49 [16383025] Genome Res. 2006 Feb;16(2):157-63 [16365381] Toxicol Sci. 2006 Apr;90(2):269-95 [16322072] Toxicol Sci. 2006 Jun;91(2):393-405 [16537655] Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11112-7 [16840560] Cancer Res. 2006 Sep 1;66(17):8462-9468 [16951157] Crit Rev Toxicol. 2006 May;36(5):459-79 [16954067] Biochim Biophys Acta. 2007 Jan;1775(1):138-62 [17045745] Cancer Res. 2007 Feb 1;67(3):946-50 [17283125] Mutat Res. 2007 Mar 1;616(1-2):7-10 [17147955] Cell. 2007 Feb 23;128(4):683-92 [17320506] Clin Cancer Res. 2007 Apr 15;13(8):2309-12 [17438087] Carcinogenesis. 2007 Jun;28(6):1171-7 [17331954] Nature. 2007 Jul 26;448(7152):445-51 [17597761] J Clin Invest. 2007 Sep;117(9):2713-22 [17717605] Int J Cancer. 2007 Dec 1;121(11):2410-20 [17680562] Mutat Res. 2007 Dec 1;625(1-2):62-71 [17586532] Carcinogenesis. 2007 Dec;28(12):2434-42 [17893234] Oncogene. 2008 Jan 10;27(3):404-8 [17621273] Chem Res Toxicol. 2008 Jan;21(1):28-44 [17970581] Environ Mol Mutagen. 2008 Jan;49(1):9-15 [17879298] Cell. 2000 Jan 7;100(1):57-70 [10647931] Clin Chem. 2000 Feb;46(2):265-72 [10657384] Cancer Res. 2000 Feb 1;60(3):588-94 [10676641] Drug Metab Rev. 2000 May;32(2):211-4 [10774776] Carcinogenesis. 2000 Dec;21(12):2141-5 [11133801] Toxicol Sci. 2001 Jul;62(1):28-35 [11399790] Mol Cell Biol. 2002 Jan;22(2):480-91 [11756544] Epigenetics. 2007 Oct-Dec;2(4):223-6 [18032927] Carcinogenesis. 2003 Jan;24(1):39-45 [12538347] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrfmmm.2008.06.009 ER - TY - JOUR T1 - beta-Estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL. AN - 69612789; 18808673 AB - Female hormones are known to play an important role in predisposition for many infectious diseases. Recent work suggests there are gender effects in HIV/AIDS progression. Here we ask whether the sex steroid hormone beta-estradiol affects the replication of HIV-1 or the efficacy of a common anti-retroviral drug, Stavudine (D4T). Human PBL were infected with HIV-1 in the presence or absence of combinations of sex steroid hormones and the anti-retroviral drug, D4T. After seven days in culture, viral supernatants were assayed for HIV-1 p24 protein. beta-estradiol resulted in a modest inhibition of HIV-1 replication of approximately 26%. However, 2 nM beta-estradiol increased the amount of HIV-1 replication in the presence of 50 nM D4T from a baseline of 33% (+/- SE = 5.4) to 74% (+/- SE = 5.4) of control virus levels in the absence of drug. Both results were statistically highly significant (p < 0.001). beta-estradiol did not increase the replication of a D4T-resistant strain of HIV in the presence of D4T. The effects were unlikely to be due to general cell inhibition or toxicity because these concentrations of drug and hormone cause no cytotoxicity in PBL as measured by trypan blue exclusion. beta-estradiol inhibited both HIV-1 replication in primary human PBL and the antiretroviral efficacy of D4T in PBL cultures. To optimize antiretroviral drug therapy, it may be necessary to monitor patient hormonal status. JF - Retrovirology AU - Zhang, Mingjie AU - Huang, Qingsheng AU - Huang, Yong AU - Wood, Owen AU - Yuan, Weishi AU - Chancey, Caren AU - Daniel, Sylvester AU - Rios, Maria AU - Hewlett, Indira AU - Clouse, Kathleen A AU - Dayton, Andrew I AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA. ming.zhang@fda.hhs.gov Y1 - 2008/09/22/ PY - 2008 DA - 2008 Sep 22 SP - 82 VL - 5 KW - Anti-HIV Agents KW - 0 KW - Culture Media KW - Gonadal Steroid Hormones KW - HIV Core Protein p24 KW - Estradiol KW - 4TI98Z838E KW - Stavudine KW - BO9LE4QFZF KW - Index Medicus KW - Drug Interactions KW - Virus Replication -- drug effects KW - Cells, Cultured KW - Humans KW - HIV Core Protein p24 -- biosynthesis KW - Female KW - Lymphocytes -- virology KW - Culture Media -- chemistry KW - Gonadal Steroid Hormones -- pharmacology KW - Anti-HIV Agents -- pharmacology KW - Stavudine -- pharmacology KW - Estradiol -- pharmacology KW - HIV-1 -- growth & development KW - HIV-1 -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69612789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Retrovirology&rft.atitle=beta-Estradiol+attenuates+the+anti-HIV-1+efficacy+of+Stavudine+%28D4T%29+in+primary+PBL.&rft.au=Zhang%2C+Mingjie%3BHuang%2C+Qingsheng%3BHuang%2C+Yong%3BWood%2C+Owen%3BYuan%2C+Weishi%3BChancey%2C+Caren%3BDaniel%2C+Sylvester%3BRios%2C+Maria%3BHewlett%2C+Indira%3BClouse%2C+Kathleen+A%3BDayton%2C+Andrew+I&rft.aulast=Zhang&rft.aufirst=Mingjie&rft.date=2008-09-22&rft.volume=5&rft.issue=&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Retrovirology&rft.issn=1742-4690&rft_id=info:doi/10.1186%2F1742-4690-5-82 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-06 N1 - Date created - 2008-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Hum Virol. 2001 May-Jun;4(3):113-22 [11572234] J Bioenerg Biomembr. 2000 Jun;32(3):317-24 [11768316] AIDS Patient Care STDS. 2002 May;16(5):211-21 [12055029] Clin Infect Dis. 2002 Aug 1;35(3):313-22 [12115098] Eur J Obstet Gynecol Reprod Biol. 2003 Aug 15;109(2):199-205 [12860342] Expert Opin Drug Metab Toxicol. 2006 Apr;2(2):273-83 [16866613] J Exp Med. 1989 Mar 1;169(3):933-51 [2538549] Antimicrob Agents Chemother. 1989 Jun;33(6):844-9 [2764535] AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1235-42 [9310291] J Infect Dis. 1998 Aug;178(2):413-22 [9697721] J Gen Intern Med. 2004 Nov;19(11):1111-7 [15566440] Biochem Pharmacol. 1988 Dec 1;37(23):4419-22 [2849444] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1742-4690-5-82 ER - TY - JOUR T1 - Risk of Cataract after Exposure to Low Doses of Ionizing Radiation: A 20-Year Prospective Cohort Study among US Radiologic Technologists AN - 19581934; 8534127 AB - The study aim was to determine the risk of cataract among radiologic technologists with respect to occupational and nonoccupational exposures to ionizing radiation and to personal characteristics. A prospective cohort of 35,705 cataract-free US radiologic technologists aged 24-44 years was followed for nearly 20 years (1983-2004) by using two follow-up questionnaires. During the study period, 2,382 cataracts and 647 cataract extractions were reported. Cigarette smoking for .5 pack-years; body mass index of .25 kg/m2 ; and history of diabetes, hypertension, hypercholesterolemia, or arthritis at baseline were significantly (p [lE] 0.05) associated with increased risk of cataract. In multivariate models, self-report of .3 x-rays to the face/neck was associated with a hazard ratio of cataract of 1.25 (95% confidence interval: 1.06, 1.47). For workers in the highest category (mean, 60 mGy) versus lowest category (mean, 5 mGy) of occupational dose to the lens of the eye, the adjusted hazard ratio of cataract was 1.18 (95% confidence interval: 0.99, 1.40). Findings challenge the National Council on Radiation Protection and International Commission on Radiological Protection assumptions that the lowest cumulative ionizing radiation dose to the lens of the eye that can produce a progressive cataract is approximately 2 Gy, and they support the hypothesis that the lowest cataractogenic dose in humans is substantially less than previously thought. JF - American Journal of Epidemiology AU - Chodick, Gabriel AU - Bekiroglu, Nural AU - Hauptmann, Michael AU - Alexander, Bruce H AU - Freedman, DMichal AU - Doody, Michele Morin AU - Cheung, Li C AU - Simon, Steven L AU - Weinstock, Robert M AU - Bouville, AndrE AU - Sigurdson, Alice J AD - 1 Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, hodik_g@mac.org.il Y1 - 2008/09/15/ PY - 2008 DA - 2008 Sep 15 SP - 620 EP - 631 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street VL - 168 IS - 6 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - cataract KW - radiation KW - technology, radiologic KW - x-rays KW - Historical account KW - Eye KW - Eye lens KW - Models KW - commissions KW - Workers KW - diabetes mellitus KW - body mass KW - Arthritis KW - Cigarette smoking KW - Hypercholesterolemia KW - Occupational exposure KW - Inventories KW - Cataracts KW - cataracts KW - Neck KW - Diabetes mellitus KW - USA KW - Ionizing radiation KW - councils KW - hypertension KW - Body mass index KW - Hypertension KW - X 24390:Radioactive Materials KW - R2 23080:Industrial and labor KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19581934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Risk+of+Cataract+after+Exposure+to+Low+Doses+of+Ionizing+Radiation%3A+A+20-Year+Prospective+Cohort+Study+among+US+Radiologic+Technologists&rft.au=Chodick%2C+Gabriel%3BBekiroglu%2C+Nural%3BHauptmann%2C+Michael%3BAlexander%2C+Bruce+H%3BFreedman%2C+DMichal%3BDoody%2C+Michele+Morin%3BCheung%2C+Li+C%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BBouville%2C+AndrE%3BSigurdson%2C+Alice+J&rft.aulast=Chodick&rft.aufirst=Gabriel&rft.date=2008-09-15&rft.volume=168&rft.issue=6&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwn171 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inventories; Cataracts; Eye lens; Neck; Models; Diabetes mellitus; Workers; Arthritis; Ionizing radiation; Cigarette smoking; Body mass index; Hypercholesterolemia; Occupational exposure; Hypertension; commissions; Historical account; diabetes mellitus; Eye; body mass; cataracts; hypertension; councils; USA DO - http://dx.doi.org/10.1093/aje/kwn171 ER - TY - JOUR T1 - Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury. AN - 69364162; 18586006 AB - Recent studies in mice suggest that stress-activated c-Jun N-terminal protein kinase 2 (JNK2) plays a pathologic role in acetaminophen (APAP)-induced liver injury (AILI), a major cause of acute liver failure (ALF). In contrast, we present evidence that JNK2 can have a protective role against AILI. When male C57BL/6J wild type (WT) and JNK2(-/-) mice were treated with 300mg APAP/kg, 90% of JNK2(-/-) mice died of ALF compared to 20% of WT mice within 48h. The high susceptibility of JNK2(-/-) mice to AILI appears to be due in part to deficiencies in hepatocyte proliferation and repair. Therefore, our findings are consistent with JNK2 signaling playing a protective role in AILI and further suggest that the use of JNK inhibitors as a potential treatment for AILI, as has been recommended by other investigators, should be reconsidered. JF - Biochemical and biophysical research communications AU - Bourdi, Mohammed AU - Korrapati, Midhun C AU - Chakraborty, Mala AU - Yee, Steven B AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1760, USA. bourdim@nih.gov Y1 - 2008/09/12/ PY - 2008 DA - 2008 Sep 12 SP - 6 EP - 10 VL - 374 IS - 1 KW - Analgesics, Non-Narcotic KW - 0 KW - Cyclin D KW - Cyclins KW - Acetaminophen KW - 362O9ITL9D KW - Mitogen-Activated Protein Kinase 9 KW - EC 2.7.1.24 KW - Index Medicus KW - Animals KW - Mice, Mutant Strains KW - Cyclins -- metabolism KW - Mice KW - Liver Regeneration -- genetics KW - Male KW - Mitogen-Activated Protein Kinase 9 -- genetics KW - Liver Failure, Acute -- genetics KW - Liver Failure, Acute -- chemically induced KW - Liver -- pathology KW - Liver -- enzymology KW - Liver -- drug effects KW - Mitogen-Activated Protein Kinase 9 -- physiology KW - Analgesics, Non-Narcotic -- toxicity KW - Liver Failure, Acute -- enzymology KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69364162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Protective+role+of+c-Jun+N-terminal+kinase+2+in+acetaminophen-induced+liver+injury.&rft.au=Bourdi%2C+Mohammed%3BKorrapati%2C+Midhun+C%3BChakraborty%2C+Mala%3BYee%2C+Steven+B%3BPohl%2C+Lance+R&rft.aulast=Bourdi&rft.aufirst=Mohammed&rft.date=2008-09-12&rft.volume=374&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=1090-2104&rft_id=info:doi/10.1016%2Fj.bbrc.2008.06.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-25 N1 - Date created - 2008-07-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Pharmacol. 1987 Apr 15;36(8):1193-6 [3593409] Hepatology. 2004 Jul;40(1):23-6 [15239082] J Clin Invest. 1995 Feb;95(2):803-10 [7860764] EMBO J. 1999 Jan 4;18(1):188-97 [9878062] Br J Pharmacol. 1999 Aug;127(7):1589-96 [10455314] Endocrinology. 2004 Dec;145(12):5439-47 [15331580] Toxicol Pathol. 2005;33(1):41-51 [15805055] Nat Rev Drug Discov. 2005 Jun;4(6):489-99 [15931258] Toxicol Sci. 2006 Jan;89(1):31-41 [16177235] Life Sci. 2006 Mar 6;78(15):1670-6 [16226279] Gastroenterology. 2006 Jul;131(1):165-78 [16831600] Gastroenterology. 2006 Jul;131(1):314-6 [16831613] Transplantation. 2006 Jul 27;82(2):241-50 [16858288] Exp Mol Med. 2006 Aug 31;38(4):408-16 [16953120] Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1536-44 [16489107] Mol Cell. 2006 Sep 15;23(6):899-911 [16973441] J Biochem Mol Biol. 2006 Sep 30;39(5):479-91 [17002867] Microbiol Mol Biol Rev. 2006 Dec;70(4):1061-95 [17158707] Chem Res Toxicol. 2007 Feb;20(2):208-16 [17305405] Hepatology. 2007 Feb;45(2):412-21 [17366662] Eur J Pharmacol. 2007 Jun 14;564(1-3):190-5 [17395177] Chem Res Toxicol. 2007 May;20(5):734-44 [17439248] Gut. 2007 Jul;56(7):982-90 [17185352] J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):160-5 [17616004] J Cell Physiol. 2007 Nov;213(2):286-300 [17559071] J Biol Chem. 2008 May 16;283(20):13565-77 [18337250] Hepatology. 2008 Sep;48(3):889-97 [18712839] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4611-6 [11287661] J Pharmacol Exp Ther. 2001 Jun;297(3):946-52 [11356915] Hepatology. 2002 Feb;35(2):289-98 [11826401] Biochem Biophys Res Commun. 2002 Jun 7;294(2):225-30 [12051698] Toxicol Appl Pharmacol. 2002 Jun 1;181(2):106-15 [12051994] FASEB J. 2002 Aug;16(10):1227-36 [12153990] Biochem J. 2003 Apr 1;371(Pt 1):199-204 [12534346] Hepatology. 2003 Apr;37(4):824-32 [12668975] Am J Physiol Gastrointest Liver Physiol. 2003 Jun;284(6):G875-9 [12736142] J Biol Chem. 2003 Jun 20;278(25):22243-9 [12646564] Toxicol Lett. 2003 Oct 15;144(3):279-88 [12927346] Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G959-66 [12842828] Drug Metab Dispos. 2003 Dec;31(12):1499-506 [14625346] Biochim Biophys Acta. 2004 Mar 11;1697(1-2):89-101 [15023353] Hepatology. 2004 May;39(5):1267-76 [15122755] Cancer Treat Res. 2004;119:217-37 [15164880] Cancer Lett. 1991 Sep;59(3):251-6 [1680544] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbrc.2008.06.065 ER - TY - JOUR T1 - Introducing Black-Gold II, a highly soluble gold phosphate complex with several unique advantages for the histochemical localization of myelin. AN - 69465846; 18657520 AB - A novel gold phosphate complex called Black-Gold II with improved myelin staining properties has been developed. It differs from its predecessor, Black-Gold, in that it is highly water soluble at room temperature. This unique physical property confers a number of advantages for the high resolution staining of myelinated fibers. Specifically, it 1) allows for easier solution preparation, eliminating the need for extended heating or sonicating; 2) produces a more uniform and consistent tracer concentration, resulting in more consistent staining and 3) can be used at a 50% higher concentration, resulting in faster and more intense staining without the need for subsequent treatment with gold chloride intensifiers. To characterize the stain, both normal rat brains as well as those exposed to the neurotoxins kainic acid or methamphetamine were examined. The study also incorporates the first application of such stains to examine peripheral nerves of control and acrylamide-exposed rats. JF - Brain research AU - Schmued, Larry AU - Bowyer, John AU - Cozart, Matthew AU - Heard, David AU - Binienda, Zbigniew AU - Paule, Merle AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson AR 72079, USA. larry.schmued@fda.hhs.gov Y1 - 2008/09/10/ PY - 2008 DA - 2008 Sep 10 SP - 210 EP - 217 VL - 1229 SN - 0006-8993, 0006-8993 KW - Black-Gold KW - 0 KW - Fluoresceins KW - Organic Chemicals KW - Phosphates KW - fluoro jade KW - Amphetamine KW - CK833KGX7E KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Rats KW - Animals KW - Nerve Degeneration -- complications KW - Myelin Sheath -- pathology KW - Nerve Degeneration -- metabolism KW - Peripheral Nervous System Diseases -- pathology KW - Nerve Degeneration -- pathology KW - Myelin Sheath -- metabolism KW - Peripheral Nervous System Diseases -- chemically induced KW - Peripheral Nervous System Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69465846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Introducing+Black-Gold+II%2C+a+highly+soluble+gold+phosphate+complex+with+several+unique+advantages+for+the+histochemical+localization+of+myelin.&rft.au=Schmued%2C+Larry%3BBowyer%2C+John%3BCozart%2C+Matthew%3BHeard%2C+David%3BBinienda%2C+Zbigniew%3BPaule%2C+Merle&rft.aulast=Schmued&rft.aufirst=Larry&rft.date=2008-09-10&rft.volume=1229&rft.issue=&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2008.06.129 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-03 N1 - Date created - 2008-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2008.06.129 ER - TY - JOUR T1 - Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume. AN - 733743203; 18778475 AB - Welding fume has been categorized as "possibly carcinogenic" to humans. Our objectives were to characterize the lung response to carcinogenic and non-carcinogenic metal-containing welding fumes and to determine if these fumes caused increased lung tumorigenicity in A/J mice, a lung tumor susceptible strain. We exposed male A/J and C57BL/6J, a lung tumor resistant strain, by pharyngeal aspiration four times (once every 3 days) to 85 mug of gas metal arc-mild steel (GMA-MS), GMA-stainless steel (SS), or manual metal arc-SS (MMA-SS) fume, or to 25.5 mug soluble hexavalent chromium (S-Cr). Shams were exposed to saline vehicle. Bronchoalveolar lavage (BAL) was done at 2, 7, and 28 days post-exposure. For the lung tumor study, gross tumor counts and histopathological changes were assessed in A/J mice at 48 and 78 weeks post-exposure. BAL revealed notable strain-dependent differences with regards to the degree and resolution of the inflammatory response after exposure to the fumes. At 48 weeks, carcinogenic metal-containing GMA-SS fume caused the greatest increase in tumor multiplicity and incidence, but this was not different from sham. By 78 weeks, tumor incidence in the GMA-SS group versus sham approached significance (p = 0.057). A significant increase in perivascular/peribronchial lymphoid infiltrates for the GMA-SS group versus sham and an increased persistence of this fume in lung cells compared to the other welding fumes was found. The increased persistence of GMA-SS fume in combination with its metal composition may trigger a chronic, but mild, inflammatory state in the lung possibly enhancing tumorigenesis in this susceptible mouse strain. JF - Particle and fibre toxicology AU - Zeidler-Erdely, Patti C AU - Kashon, Michael L AU - Battelli, Lori A AU - Young, Shih-Houng AU - Erdely, Aaron AU - Roberts, Jenny R AU - Reynolds, Steven H AU - Antonini, James M AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA. paz9@cdc.gov. Y1 - 2008/09/08/ PY - 2008 DA - 2008 Sep 08 SP - 12 VL - 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733743203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Pulmonary+inflammation+and+tumor+induction+in+lung+tumor+susceptible+A%2FJ+and+resistant+C57BL%2F6J+mice+exposed+to+welding+fume.&rft.au=Zeidler-Erdely%2C+Patti+C%3BKashon%2C+Michael+L%3BBattelli%2C+Lori+A%3BYoung%2C+Shih-Houng%3BErdely%2C+Aaron%3BRoberts%2C+Jenny+R%3BReynolds%2C+Steven+H%3BAntonini%2C+James+M&rft.aulast=Zeidler-Erdely&rft.aufirst=Patti&rft.date=2008-09-08&rft.volume=5&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-5-12 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2008-09-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Med Chem. 2007;14(12):1279-89 [17504213] Toxicol Appl Pharmacol. 2007 Sep 15;223(3):234-45 [17706736] J Occup Environ Hyg. 2006 Apr;3(4):194-203; quiz D45 [16531292] Mol Cell Biochem. 2005 Nov;279(1-2):17-23 [16283511] Genes Dev. 2005 Mar 15;19(6):643-64 [15769940] J Natl Cancer Inst. 1999 Apr 21;91(8):675-90 [10218505] Int J Occup Environ Health. 1998 Apr-Jun;4(2):85-8 [10026469] Toxicol Lett. 1998 Sep 1;98(1-2):77-86 [9776564] Exp Lung Res. 1998 Jul-Aug;24(4):541-55 [9659582] Carcinogenesis. 1997 Oct;18(10):1917-20 [9364000] Scand J Work Environ Health. 1997 Apr;23(2):104-13 [9167233] Int J Radiat Biol. 1997 Mar;71(3):301-8 [9134020] Carcinogenesis. 1997 Mar;18(3):531-7 [9067553] Am J Ind Med. 1996 Oct;30(4):383-91 [8892542] Toxicol Appl Pharmacol. 1996 Sep;140(1):188-99 [8806885] Cancer Res. 1996 May 1;56(9):2224-8 [8616876] Toxicol Pathol. 1991;19(2):168-75 [1771369] Cancer Res. 1992 Jun 1;52(11):3164-73 [1591728] Exp Lung Res. 1991 Mar-Apr;17(2):157-68 [2050022] Am Rev Respir Dis. 1991 May;143(5 Pt 1):1134-48 [2024826] IARC Monogr Eval Carcinog Risks Hum. 1990;49:1-648 [2232124] Toxicol Pathol. 1989;17(4 Pt 2):737-42 [2483278] J Natl Cancer Inst. 1987 Apr;78(4):743-9 [3470549] Exp Pathol. 1986;30(3):129-41 [3792485] J Natl Cancer Inst. 1985 Nov;75(5):963-9 [3863993] Toxicol Lett. 1982 Apr;11(1-2):159-63 [6896394] Scand J Work Environ Health. 1977 Dec;3(4):203-11 [339336] Mutat Res. 1978 Jan;56(3):235-43 [342941] Adv Cancer Res. 1975;21:1-58 [1108612] Toxicol Sci. 2004 Sep;81(1):26-34 [15159525] Cancer Res. 2004 Apr 1;64(7):2307-16 [15059877] Inhal Toxicol. 2004 Jan;16(1):27-32 [14744662] Toxicol Sci. 2003 Sep;75(1):181-91 [12832661] J Toxicol Environ Health A. 2003 Aug 8;66(15):1441-52 [12857634] Crit Rev Toxicol. 2003;33(1):61-103 [12585507] Scand J Work Environ Health. 2002 Jun;28(3):163-7 [12109555] Respir Res. 2000;1(3):163-9 [11667981] Methods. 2001 Dec;25(4):402-8 [11846609] Anticancer Res. 2001 May-Jun;21(3B):1749-55 [11497255] Cancer Res. 2000 Sep 15;60(18):5017-20 [11016621] J Toxicol Environ Health A. 1999 Nov 26;58(6):343-63 [10580758] Carcinogenesis. 2000 Apr;21(4):533-41 [10753182] J Immunol Methods. 2008 Feb 29;331(1-2):59-68 [18089291] Scand J Work Environ Health. 2007 Oct;33(5):379-86 [17973064] Toxicol Pathol. 2006;34(4):364-72 [16844664] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1743-8977-5-12 ER - TY - CPAPER T1 - Monitoring of Nutrition Labeling and Determination of Ascorbic acid and Calcium in Fortified Food T2 - 15th International Congress of Dietetics (ICD 2008) AN - 41096117; 4939793 JF - 15th International Congress of Dietetics (ICD 2008) AU - Jang, Jin-Wook Y1 - 2008/09/08/ PY - 2008 DA - 2008 Sep 08 KW - Nutrition KW - Calcium KW - Food KW - Ascorbic acid KW - Vitamin C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41096117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Congress+of+Dietetics+%28ICD+2008%29&rft.atitle=Monitoring+of+Nutrition+Labeling+and+Determination+of+Ascorbic+acid+and+Calcium+in+Fortified+Food&rft.au=Jang%2C+Jin-Wook&rft.aulast=Jang&rft.aufirst=Jin-Wook&rft.date=2008-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Congress+of+Dietetics+%28ICD+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ics-inc.co.jp/icd2008/5top.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Acetylcholine release in the mesocorticolimbic dopamine system during cocaine seeking: conditioned and unconditioned contributions to reward and motivation. AN - 69513157; 18768696 AB - Microdialysis was used to assess the contribution to cocaine seeking of cholinergic input to the mesocorticolimbic dopamine system in ventral tegmental area (VTA). VTA acetylcholine (ACh) was elevated in animals lever pressing for intravenous cocaine and in cocaine-experienced and cocaine-naive animals passively receiving similar "yoked" injections. In cocaine-trained animals, the elevations comprised an initial (first hour) peak to approximately 160% of baseline and a subsequent plateau of 140% of baseline for the rest of the cocaine intake period. In cocaine-naive animals, yoked cocaine injections raised ACh levels to the 140% plateau but did not cause the initial 160% peak. In cocaine-trained animals that received unexpected saline (extinction conditions) rather than the expected cocaine, the initial peak was seen but the subsequent plateau was absent. VTA ACh levels played a causal role and were not just a correlate of cocaine seeking. Blocking muscarinic input to the VTA increased cocaine intake; the increase in intake offset the decrease in cholinergic input, resulting in the same VTA dopamine levels as were seen in the absence of the ACh antagonists. Increased VTA ACh levels (resulting from 10 microM VTA neostigmine infusion) increased VTA dopamine levels and reinstated cocaine seeking in cocaine-trained animals that had undergone extinction; these effects were strongly attenuated by local infusion of a muscarinic antagonist and weakly attenuated by a nicotinic antagonist. These findings identify two cholinergic responses to cocaine self-administration, an unconditioned response to cocaine itself and a conditioned response triggered by cocaine-predictive cues, and confirm that these cholinergic responses contribute to the control of cocaine seeking. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - You, Zhi-Bing AU - Wang, Bin AU - Zitzman, Dawnya AU - Wise, Roy A AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. zyou@intra.nida.nih.gov Y1 - 2008/09/03/ PY - 2008 DA - 2008 Sep 03 SP - 9021 EP - 9029 VL - 28 IS - 36 KW - Cholinergic Antagonists KW - 0 KW - Mecamylamine KW - 6EE945D3OK KW - Atropine KW - 7C0697DR9I KW - Cocaine KW - I5Y540LHVR KW - Acetylcholine KW - N9YNS0M02X KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Extinction, Psychological KW - Rats, Long-Evans KW - Substantia Nigra -- drug effects KW - Mecamylamine -- pharmacology KW - Cholinergic Antagonists -- pharmacology KW - Cocaine -- administration & dosage KW - Microdialysis -- methods KW - Substantia Nigra -- metabolism KW - Rats KW - Self Administration -- methods KW - Behavior, Animal -- physiology KW - Atropine -- pharmacology KW - Male KW - Acetylcholine -- metabolism KW - Reward KW - Motivation KW - Conditioning (Psychology) -- physiology KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- physiopathology KW - Dopamine -- metabolism KW - Ventral Tegmental Area -- metabolism KW - Ventral Tegmental Area -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69513157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Acetylcholine+release+in+the+mesocorticolimbic+dopamine+system+during+cocaine+seeking%3A+conditioned+and+unconditioned+contributions+to+reward+and+motivation.&rft.au=You%2C+Zhi-Bing%3BWang%2C+Bin%3BZitzman%2C+Dawnya%3BWise%2C+Roy+A&rft.aulast=You&rft.aufirst=Zhi-Bing&rft.date=2008-09-03&rft.volume=28&rft.issue=36&rft.spage=9021&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.0694-08.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-16 N1 - Date created - 2008-09-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 1996 Aug 19;730(1-2):133-42 [8883897] Brain Res. 1999 Aug 21;839(1):85-93 [10482802] Nature. 1997 Nov 27;390(6658):401-4 [9389479] J Neurosci. 1998 Jul 1;18(13):5035-44 [9634569] J Comp Neurol. 2005 Mar 7;483(2):217-35 [15678476] J Neurosci. 2000 Feb 15;20(4):1635-42 [10662853] Pharmacol Biochem Behav. 2000 Mar;65(3):375-9 [10683476] J Neurosci. 2000 Oct 1;20(19):7489-95 [11007908] Eur J Neurosci. 2000 Oct;12(10):3596-604 [11029630] J Neurosci. 2001 Mar 1;21(5):1452-63 [11222635] J Neurosci. 2001 Aug 1;21(15):5841-6 [11466456] Neuroscience. 2001;106(3):633-41 [11591463] J Neurosci. 2002 Jan 1;22(1):RC190 [11756520] J Neurosci. 2002 Jul 15;22(14):6247-53 [12122083] Eur J Pharmacol. 2003 Sep 5;477(1):37-44 [14512096] J Neurosci. 2003 Oct 15;23(28):9305-11 [14561857] Psychopharmacology (Berl). 2004 Aug;175(1):53-9 [14767633] J Pharmacol Exp Ther. 1968 May;161(1):122-9 [5648489] J Comp Physiol Psychol. 1969 May;68(1):22-30 [5798120] Psychopharmacologia. 1974 Jan 14;34(3):255-64 [4819978] Biochem Pharmacol. 1975 Apr 15;24(8):847-52 [1125084] Nature. 1976 Mar 18;260(5548):258-60 [1256567] Can J Psychol. 1977 Dec;31(4):195-203 [608135] Brain Res. 1980 Mar 3;185(1):1-15 [7353169] Brain Res. 1981 May 25;213(1):190-4 [7016258] Science. 1983 Aug 19;221(4612):773-5 [6879176] Brain Res. 1985 Mar 11;329(1-2):19-26 [3872153] Brain Res. 1985 Dec 2;348(2):355-8 [4075093] Neurosci Lett. 1986 May 23;66(3):281-6 [2425289] Brain Res Bull. 1986 May;16(5):603-37 [3742247] Neuroscience. 1986 Oct;19(2):551-64 [3774154] Acta Physiol Scand. 1986 Nov;128(3):351-8 [3788613] Eur J Pharmacol. 1987 Sep 23;141(3):395-9 [3666033] J Neurosci. 1988 Jan;8(1):100-12 [3339402] Neuroscience. 1989;28(3):611-23 [2710334] Pharmacol Biochem Behav. 1989 Feb;32(2):527-31 [2727015] Pharmacol Biochem Behav. 1988 Nov;31(3):547-59 [3251239] J Comp Neurol. 1989 Jun 8;284(2):314-35 [2754038] J Neurosci. 1989 Oct;9(10):3400-9 [2795130] Pharmacol Biochem Behav. 1989 Dec;34(4):899-904 [2623043] J Neurosci. 1990 Aug;10(8):2541-59 [2388079] Neurosci Lett. 1990 Jul 3;114(2):154-9 [2395528] Synapse. 1990;6(1):106-12 [1697988] Proc Natl Acad Sci U S A. 1990 Sep;87(18):7050-4 [2402490] Brain Res. 1990 Aug 27;526(1):45-53 [2078817] Neuroscience. 1991;41(2-3):483-94 [1678502] Synapse. 1994 Jan;16(1):36-44 [8134899] Pharmacol Toxicol. 1994 Dec;75(6):348-52 [7534921] J Neurosci. 1995 Sep;15(9):5859-69 [7666171] Psychopharmacology (Berl). 1995 Jul;120(1):10-20 [7480530] J Neurosci. 1996 Jan 15;16(2):714-22 [8551354] J Comp Neurol. 1995 Dec 11;363(2):177-96 [8642069] Psychopharmacology (Berl). 1995 Nov;122(2):194-7 [8848536] J Comp Neurol. 1996 Jan 8;364(2):254-66 [8788248] J Neurosci. 2005 May 11;25(19):4725-32 [15888648] J Comp Neurol. 2006 Feb 20;494(6):863-75 [16385486] Brain Res. 2006 Oct 20;1116(1):143-52 [16942754] J Neurosci. 2007 May 23;27(21):5730-43 [17522317] J Neurosci. 2007 Sep 26;27(39):10546-55 [17898226] Neuroreport. 2008 Jun 11;19(9):991-5 [18521007] Synapse. 1999 Mar 15;31(4):241-9 [10051104] Pharmacol Biochem Behav. 1997 Aug;57(4):915-21 [9259024] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.0694-08.2008 ER - TY - JOUR T1 - Body size and the risk of biliary tract cancer: a population-based study in China AN - 19607504; 8586559 AB - Though obesity is an established risk factor for gall bladder cancer, its role in cancers of the extrahepatic bile ducts and ampulla of Vater is less clear, as also is the role of abdominal obesity. In a population-based case-control study of biliary tract cancer in Shanghai, China, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for biliary tract cancer in relation to anthropometric measures, including body mass index (BMI) at various ages and waist-to-hip ratio (WHR), adjusting for age, sex, and education. The study included 627 patients with biliary tract cancer (368 gall bladder, 191 bile duct, 68 ampulla of Vater) and 959 healthy subjects randomly selected from the population. A higher BMI at all ages, including early adulthood (ages 20-29 years), and a greater WHR were associated with an increased risk of gall bladder cancer. A high usual adult BMI ( greater than or equal to 25) was associated with a 1.6-fold risk of gall bladder cancer (95% CI 1.2-2.1, P fortrend 0.90) having the highest risk of gall bladder cancer (OR= 12.6, 95% CI 4.8-33.2), relative to those with a low BMI and WHR We found no clear risk patterns for cancers of the bile duct and ampulla of Vater. These results suggest that both overall and abdominal obesity, including obesity in early adulthood, are associated with an increased risk of gall bladder cancer. The increasing prevalence of obesity and cholesterol stones in Shanghai seems at least partly responsible for the rising incidence of gall bladder cancer in Shanghai. JF - British Journal of Cancer AU - Hsing, A W AU - Sakoda, L C AU - Rashid, A AU - Chen, J AU - Shen, M C AU - Han, T Q AU - Wang, B S AU - Gao, Y T AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd. EPS 5024, Bethesda, MD 20892-7324, USA, hsinga@mail.nih.gov Y1 - 2008/09/02/ PY - 2008 DA - 2008 Sep 02 SP - 811 EP - 815 VL - 99 IS - 5 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Age KW - obesity KW - body size KW - cholesterol KW - Cancer KW - urinary bladder KW - Education KW - body mass KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19607504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Body+size+and+the+risk+of+biliary+tract+cancer%3A+a+population-based+study+in+China&rft.au=Hsing%2C+A+W%3BSakoda%2C+L+C%3BRashid%2C+A%3BChen%2C+J%3BShen%2C+M+C%3BHan%2C+T+Q%3BWang%2C+B+S%3BGao%2C+Y+T&rft.aulast=Hsing&rft.aufirst=A&rft.date=2008-09-02&rft.volume=99&rft.issue=5&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604616 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - China, People's Rep., Shanghai; China, People's Rep.; Cancer; urinary bladder; obesity; Age; cholesterol; Education; body mass; body size DO - http://dx.doi.org/10.1038/sj.bjc.6604616 ER - TY - JOUR T1 - Evaluation of the renal effects of experimental feeding of melamine and cyanuric acid to fish and pigs AN - 745637203; 13097828 AB - Objective--To determine whether renal crystals can be experimentally induced in animals fed melamine or the related triazine compound cyanuric acid, separately or in combination, and to compare experimentally induced crystals with those from a cat with triazine-related renal failure. Animals--75 fish (21 tilapia, 24 rainbow trout, 15 channel catfish, and 15 Atlantic salmon), 4 pigs, and 1 cat that was euthanatized because of renal failure. Procedures--Fish and pigs were fed a target dosage of melamine (400 mg/kg), cyanuric acid (400 mg/kg), or melamine and cyanuric acid (400 mg of each compound/kg) daily for 3 days and were euthanatized 1, 3, 6, 10, or 14 days after administration ceased. Fresh, frozen, and formalin-fixed kidneys were examined for crystals. Edible tissues were collected for residue analysis. Crystals were examined for composition via Raman spectroscopy and hydrophilic-interaction liquid chromatography-tandem mass spectrometry. Results--All animals fed the combination of melamine and cyanuric acid developed goldbrown renal crystals arranged in radial spheres (spherulites), similar to those detected in the cat. Spectral analyses of crystals from the cat, pigs, and fish were consistent with melamine-cyanurate complex crystals. Melamine and cyanuric acid residues were identified in edible tissues of fish. Conclusions and Clinical Relevance--Although melamine and cyanuric acid appeared to have low toxicity when administered separately, they induced extensive renal crystal formation when administered together. The subsequent renal failure may be similar to acute uric acid nephropathy in humans, in which crystal spherulites obstruct renal tubules. JF - American Journal of Veterinary Research AU - Reimschuessel, R AU - Gieseker, C M AU - Miller, R A AU - Ward, J AU - Boehmer, J AU - Rummel, N AU - Heller, D N AU - Nochetto, C AU - de Alwis, GKH AU - Bataller, N AU - Andersen, W C AU - Turnipseed, S B AU - Karbiwnyk, C M AU - Satzger, R D AD - Center for Veterinary Medicine, US FDA, 8401 Muirkirk Rd, Laurel, MD 20708, USA Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1217 EP - 1228 VL - 69 IS - 9 SN - 0002-9645, 0002-9645 KW - Toxicology Abstracts KW - Feeding KW - Renal failure KW - Oncorhynchus mykiss KW - Cyanuric acid KW - Toxicity KW - Crystals KW - Tilapia KW - Ictalurus punctatus KW - Salmo salar KW - Mass spectroscopy KW - triazine KW - Raman spectroscopy KW - renal tubules KW - Nephropathy KW - spherulites KW - Kidney KW - Uric acid KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745637203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Veterinary+Research&rft.atitle=Evaluation+of+the+renal+effects+of+experimental+feeding+of+melamine+and+cyanuric+acid+to+fish+and+pigs&rft.au=Reimschuessel%2C+R%3BGieseker%2C+C+M%3BMiller%2C+R+A%3BWard%2C+J%3BBoehmer%2C+J%3BRummel%2C+N%3BHeller%2C+D+N%3BNochetto%2C+C%3Bde+Alwis%2C+GKH%3BBataller%2C+N%3BAndersen%2C+W+C%3BTurnipseed%2C+S+B%3BKarbiwnyk%2C+C+M%3BSatzger%2C+R+D&rft.aulast=Reimschuessel&rft.aufirst=R&rft.date=2008-09-01&rft.volume=69&rft.issue=9&rft.spage=1217&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Veterinary+Research&rft.issn=00029645&rft_id=info:doi/10.2460%2Fajvr.69.9.1217 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Feeding; Renal failure; Cyanuric acid; Crystals; Toxicity; Mass spectroscopy; triazine; Raman spectroscopy; renal tubules; spherulites; Nephropathy; Kidney; Uric acid; Oncorhynchus mykiss; Tilapia; Salmo salar; Ictalurus punctatus DO - http://dx.doi.org/10.2460/ajvr.69.9.1217 ER - TY - JOUR T1 - Variants in Iron Metabolism Genes Predict Higher Blood Lead Levels in Young Children AN - 743551982; 201004-31-0306918 (CE); 12108116 (EN) AB - BACKGROUND: Given the association between iron deficiency and lead absorption, we hypothesized that variants in iron metabolism genes would predict higher blood lead levels in young children. OBJECTIVE: We examined the association between common missense variants in the hemochromatosis (HFE) and transferrin (TF) genes and blood lead levels in 422 Mexican children. METHODS: Archived umbilical cord blood samples were genotyped for HFE (H63D and C282Y) and TF (P570S) variants. Blood lead was measured at 24, 30, 36, 42, and 48 months of age. A total of 341 subjects had at least one follow-up blood lead level available and data available on covariates of interest for inclusion in the longitudinal analyses. We used random-effects models to examine the associations between genotype (HFE, TF, and combined HFE + TF) and repeated measures of blood lead, adjusting for maternal blood lead at delivery and child's concurrent anemia status. RESULTS: Of 422 children genotyped, 17.7, 3.3, and 18.9% carried the HFE H63D, HFE C282Y, and TF P570S variants, respectively. One percent of children carried both the HFE C282Y and TF P570S variants, and 3% of children carried both the HFE H63D and TF P570S variants. On average, carriers of either the HFE (beta = 0.11, p = 0.04) or TF (beta = 0.10, p = 0.08) variant had blood lead levels that were 11% and 10% higher, respectively, than wild-type subjects. In models examining the dose effect, subjects carrying both variants (beta = 0.41, p = 0.006) had blood lead 50% higher than wild-type subjects and a significantly higher odds of having a blood lead level 10 microg/dL (odds ratio = 18.3; 95% confidence interval, 1.9-177.1). CONCLUSIONS: Iron metabolism gene variants modify lead metabolism such that HFE variants are associated with increased blood lead levels in young children. The joint presence of variant alleles in the HFE and TF genes showed the greatest effect, suggesting a gene-by-gene-by-environment interaction. JF - Environmental Health Perspectives AU - Hopkins, Marianne R AU - Ettinger, Adrienne S AU - Hernandez-Avila, Mauricio AU - Schwartz, Joel AU - Tellez-Rojo, Martha Maria AU - Lamadrid-Figueroa, Hector AU - Bellinger, David AU - Hu, Howard AU - Wright, Robert O PY - 2008 SP - 1261 EP - 1266 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Blood KW - Children KW - Genes KW - Iron KW - Metabolism KW - Beta KW - Iron and steel industry KW - Health KW - Confidence intervals KW - Copyrights KW - Umbilical cords KW - Transferrin KW - Carriers KW - Mathematical models KW - Inclusions KW - Anemias KW - Age KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743551982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Variants+in+Iron+Metabolism+Genes+Predict+Higher+Blood+Lead+Levels+in+Young+Children&rft.au=Hopkins%2C+Marianne+R%3BEttinger%2C+Adrienne+S%3BHernandez-Avila%2C+Mauricio%3BSchwartz%2C+Joel%3BTellez-Rojo%2C+Martha+Maria%3BLamadrid-Figueroa%2C+Hector%3BBellinger%2C+David%3BHu%2C+Howard%3BWright%2C+Robert+O&rft.aulast=Hopkins&rft.aufirst=Marianne&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1261&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Temporal, Multicity Model to Estimate the Effects of Short-Term Exposure to Ambient Air Pollution on Health AN - 743530135; 201004-31-0306938 (CE); 12108139 (EN) AB - BACKGROUND: Countries worldwide are expending significant resources to improve air quality partly to improve the health of their citizens. Are these societal expenditures improving public health? OBJECTIVES: We consider these issues by tracking the risk of death associated with outdoor air pollution over both space and time in Canadian cities. MATERIALS AND METHODS: We propose two multi-year estimators that use current plus several previous years of data to estimate current year risk. The estimators are derived from sequential time series analyses using moving time windows. To evaluate the statistical properties of the proposed methods, a simulation study with three scenarios of changing risk was conducted based on 12 Canadian cities from 1981 to 2000. Then an optimal estimator was applied to 24 of Canada's largest cities over the 17-year period from 1984 to 2000. RESULTS: The annual average daily concentrations of ozone appeared to be increasing over the time period, whereas those of nitrogen dioxide were decreasing. However, the proposed method returns different time trends in public health risks. Evidence for some monotonic increasing trends in the annual risks is weak for O(3) (p = 0.3870) but somewhat stronger for NO(2) (p = 0.1082). In particular, an increasing time trend becomes apparent when excluding year 1998, which reveals lower risk than proximal years, even though concentrations of NO(2) were decreasing. The simulation results validate our two proposed methods, producing estimates close to the preassigned values. CONCLUSIONS: Despite decreasing ambient concentrations, public health risks related to NO(2) appear to be increasing. Further investigations are necessary to understand why the concentrations and adverse effects of NO(2) show opposite time trends. JF - Environmental Health Perspectives AU - Shin, Hwashin Hyun AU - Stieb, David M AU - Jessiman, Barry AU - Goldberg, Mark S AU - Brion, Orly AU - Brook, Jeff AU - Ramsay, Tim AU - Burnett, Richard T PY - 2008 SP - 1147 EP - 1153 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Health KW - Mathematical models KW - Trends KW - Estimates KW - Estimators KW - Public health KW - Air pollution KW - Simulation KW - Windows (intervals) KW - Time series analysis KW - Nitrogen dioxide KW - Expenditures KW - Tracking KW - Ozone KW - Copyrights KW - Air quality KW - Temporal logic KW - Death KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743530135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Temporal%2C+Multicity+Model+to+Estimate+the+Effects+of+Short-Term+Exposure+to+Ambient+Air+Pollution+on+Health&rft.au=Shin%2C+Hwashin+Hyun%3BStieb%2C+David+M%3BJessiman%2C+Barry%3BGoldberg%2C+Mark+S%3BBrion%2C+Orly%3BBrook%2C+Jeff%3BRamsay%2C+Tim%3BBurnett%2C+Richard+T&rft.aulast=Shin&rft.aufirst=Hwashin&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Pyrethroid Pesticide Esfenvalerate Suppresses the Afternoon Rise of Luteinizing Hormone and Delays Puberty in Female Rats AN - 743516294; 201004-31-0306921 (CE); 12108122 (EN) AB - BACKGROUND: One of the most widely used classes of insecticides is the synthetic pyrethroids. Although pyrethroids are less acutely toxic to humans than to insects, in vitro studies have suggested that pyrethroids may be estrogenic. OBJECTIVES: We assessed pubertal effects by orally administering 0.5, 1.0, and 5.0 mg/kg/day of the type II pyrethroid esfenvalerate (ESF) to female rats beginning on postnatal day (PND) 22 until vaginal opening. ESF administration suppresses serum estradiol and delays pubertal onset. MATERIALS AND METHODS: To assess possible hypothalamic and/or pituitary effects, animals received 0.5 or 1.0 mg/kg ESF or corn oil on PNDs 22-29. On PND30, we drew three blood samples (200 microL) from each rat at 15-min intervals beginning at 1000 hours, and again at 1500 hours. To test hypothalamic responsiveness, after the third afternoon sample, all animals received an intravenous injection of N-methyl-d,l-aspartic acid (NMA; 40 mg/kg), and then we drew two more samples. We performed a second experiment as above except that animals received luteinizing hormone-releasing hormone (LHRH; 25 ng/rat) to test pituitary responsiveness. RESULTS: Basal levels of luteinizing hormone (LH) in the afternoon hours were higher in control animals than in animals treated with 1.0 mg/kg ESF (p 0.05). Furthermore, NMA- and LHRH-stimulated LH release was similar in control and ESF-treated animals, indicating that both hypothalamic and pituitary responsiveness, respectively, were unaffected. CONCLUSIONS: Although the hypothalamus is able to respond to exogenous stimuli, absence of a normal afternoon rise in LH would indicate a hypothalamic deficit in ESF-treated animals. JF - Environmental Health Perspectives AU - Pine, Michelle D AU - Hiney, Jill K AU - Lee, Boyeon AU - Dees, W Les PY - 2008 SP - 1243 EP - 1247 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Animals KW - Hormones KW - Delay KW - Health KW - Females KW - Rats KW - Stimuli KW - Hypothalamus KW - Insecticides KW - Intervals KW - In vitro testing KW - Pine KW - Corn oil KW - Toxic KW - Pesticides KW - Insects KW - Copyrights KW - Serums KW - Human KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743516294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Pyrethroid+Pesticide+Esfenvalerate+Suppresses+the+Afternoon+Rise+of+Luteinizing+Hormone+and+Delays+Puberty+in+Female+Rats&rft.au=Pine%2C+Michelle+D%3BHiney%2C+Jill+K%3BLee%2C+Boyeon%3BDees%2C+W+Les&rft.aulast=Pine&rft.aufirst=Michelle&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1243&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Effects of Air Pollution on Mortality in Socially Deprived Urban Areas in Hong Kong, China AN - 743511566; 201004-31-0306931 (CE); 12108132 (EN) AB - BACKGROUND: Poverty is a major determinant of population health, but little is known about its role in modifying air pollution effects. OBJECTIVES: We set out to examine whether people residing in socially deprived communities are at higher mortality risk from ambient air pollution. METHODS: This study included 209 tertiary planning units (TPUs), the smallest units for town planning in the Special Administrative Region of Hong Kong, China. The socioeconomic status of each TPU was measured by a social deprivation index (SDI) derived from the proportions of the population with a) unemployment, b) monthly household income US$250, c) no schooling at all, d) one-person household, e) never-married status, and f ) subtenancy, from the 2001 Population Census. TPUs were classified into three levels of SDI: low, middle, and high. We performed time-series analysis with Poisson regression to examine the association between changes in daily concentrations of ambient air pollution and daily number of deaths in each SDI group for the period from January 1996 to December 2002. We evaluated the differences in pollution effects between different SDI groups using a case-only approach with logistic regression. RESULTS: We found significant associations of nitrogen dioxide, sulfur dioxide, particulate matter with aerodynamic diameter 10 mum, and ozone with all nonaccidental and cardiovascular mortality in areas of middle or high SDI (p 0.05). Health outcomes, measured as all nonaccidental, cardiovascular, and respiratory mortality, in people residing in high SDI areas were more strongly associated with SO(2) and NO(2) compared with those in middle or low SDI areas. CONCLUSIONS: Neighborhood socioeconomic deprivation increases mortality risks associated with air pollution. JF - Environmental Health Perspectives AU - Wong, Chit-Ming AU - Ou, Chun-Quan AU - Chan, King-Pan AU - Chau, Yuen-Kwan AU - Thach, Thuan-Quoc AU - Yang, Lin AU - Chung, Roger Yat-Nork AU - Thomas, Graham Neil AU - Peiris, Joseph Sriyal Malik AU - Wong, Tze-Wai AU - Hedley, Anthony Johnson AU - Lam, Tai-Hing PY - 2008 SP - 1189 EP - 1194 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Air pollution KW - Mortality KW - Health KW - Urethane thermoplastic elastomers KW - Risk KW - Regression KW - Households KW - Deprivation KW - Nitrogen dioxide KW - Census KW - Determinants KW - Regression analysis KW - Town planning KW - Sulfur dioxide KW - Communities KW - Ozone KW - Copyrights KW - Logistics KW - Income KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743511566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Effects+of+Air+Pollution+on+Mortality+in+Socially+Deprived+Urban+Areas+in+Hong+Kong%2C+China&rft.au=Wong%2C+Chit-Ming%3BOu%2C+Chun-Quan%3BChan%2C+King-Pan%3BChau%2C+Yuen-Kwan%3BThach%2C+Thuan-Quoc%3BYang%2C+Lin%3BChung%2C+Roger+Yat-Nork%3BThomas%2C+Graham+Neil%3BPeiris%2C+Joseph+Sriyal+Malik%3BWong%2C+Tze-Wai%3BHedley%2C+Anthony+Johnson%3BLam%2C+Tai-Hing&rft.aulast=Wong&rft.aufirst=Chit-Ming&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Public Health and Air Pollution in Asia (PAPA) Project: Estimating the Mortality Effects of Particulate Matter in Bangkok, Thailand AN - 743511443; 201004-31-0306929 (CE); 12108130 (EN) AB - BACKGROUND: Air pollution data in Bangkok, Thailand, indicate that levels of particulate matter with aerodynamic diameter or = 10 microm (PM(10)) are significantly higher than in most cities in North America and Western Europe, where the health effects of PM(10) are well documented. However, the pollution mix, seasonality, and demographics are different from those in developed Western countries. It is important, therefore, to determine whether the large metropolitan area of Bangkok is subject to similar effects of PM(10). OBJECTIVES: This study was designed to investigate the mortality risk from air pollution in Bangkok, Thailand. METHODS: The study period extended from 1999 to 2003, for which the Ministry of Public Health provided the mortality data. Measures of air pollution were derived from air monitoring stations, and information on temperature and relative humidity was obtained from the weather station in central Bangkok. The statistical analysis followed the common protocol for the multicity PAPA (Public Health and Air Pollution Project in Asia) project in using a natural cubic spline model with smooths of time and weather. RESULTS: The excess risk for non-accidental mortality was 1.3% [95% confidence interval (CI), 0.8-1.7] per 10 microg/m(3) of PM(10), with higher excess risks for cardiovascular and above age 65 mortality of 1.9% (95% CI, 0.8-3.0) and 1.5% (95% CI, 0.9-2.1), respectively. In addition, the effects from PM(10) appear to be consistent in multipollutant models. CONCLUSIONS: The results suggest strong associations between several different mortality outcomes and PM(10). In many cases, the effect estimates were higher than those typically reported in Western industrialized nations. JF - Environmental Health Perspectives AU - Vichit-Vadakan, Nuntavarn AU - Vajanapoom, Nitaya AU - Ostro, Bart PY - 2008 SP - 1179 EP - 1182 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Air pollution KW - Mortality KW - Bangkok KW - Risk KW - Health KW - Public health KW - Relative humidity KW - Estimating KW - Metropolitan areas KW - Estimates KW - Weather KW - Climatology KW - Statistical analysis KW - Nations KW - Stations KW - Weather stations KW - Mathematical models KW - Confidence intervals KW - Splines KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743511443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Business+Ethics+Quarterly&rft.atitle=What+is+%28and+isn%27t%29+the+matter+with+%22what%27s+the+matter+...%22&rft.au=Monast%2C+Joseph+H&rft.aulast=Monast&rft.aufirst=Joseph&rft.date=1994-10-01&rft.volume=4&rft.issue=4&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Business+Ethics+Quarterly&rft.issn=1052150X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Season, Sex, Age, and Education as Modifiers of the Effects of Outdoor Air Pollution on Daily Mortality in Shanghai, China: The Public Health and Air Pollution in Asia (PAPA) Study AN - 743478529; 201004-31-0306932 (CE); 12108133 (EN) AB - BACKGROUND: Various factors can modify the health effects of outdoor air pollution. Prior findings about modifiers are inconsistent, and most of these studies were conducted in developed countries. OBJECTIVES: We conducted a time-series analysis to examine the modifying effect of season, sex, age, and education on the association between outdoor air pollutants [particulate matter 10 microm in aerodynamic diameter (PM(10)), sulfur dioxide, nitrogen dioxide, and ozone] and daily mortality in Shanghai, China, using 4 years of daily data (2001-2004). METHODS: Using a natural spline model to analyze the data, we examined effects of air pollution for the warm season (April-September) and cool season (October-March) separately. For total mortality, we examined the association stratified by sex and age. Stratified analysis by educational attainment was conducted for total, cardiovascular, and respiratory mortality. RESULTS: Outdoor air pollution was associated with mortality from all causes and from cardiorespiratory diseases in Shanghai. An increase of 10 mug/m(3) in a 2-day average concentration of PM(10), SO(2), NO(2), and O(3) corresponds to increases in all-cause mortality of 0.25% [95% confidence interval (CI), 0.14-0.37), 0.95% (95% CI, 0.62-1.28), 0.97% (95% CI, 0.66-1.27), and 0.31% (95% CI, 0.04-0.58), respectively. The effects of air pollutants were more evident in the cool season than in the warm season, and females and the elderly were more vulnerable to outdoor air pollution. Effects of air pollution were generally greater in residents with low educational attainment (illiterate or primary school) compared with those with high educational attainment (middle school or above). CONCLUSIONS: Season, sex, age, and education may modify the health effects of outdoor air pollution in Shanghai. These findings provide new information about the effects of modifiers on the relationship between daily mortality and air pollution in developing countries and may have implications for local environmental and social policies. JF - Environmental Health Perspectives AU - Kan, Haidong AU - London, Stephanie J AU - Chen, Guohai AU - Zhang, Yunhui AU - Song, Guixiang AU - Zhao, Naiqing AU - Jiang, Lili AU - Chen, Bingheng PY - 2008 SP - 1183 EP - 1188 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Air pollution KW - Mortality KW - Education KW - Outdoor KW - Seasons KW - Health KW - Sex KW - Age KW - Cool season KW - Mathematical models KW - Pollutants KW - Policies KW - Diseases KW - Nitrogen dioxide KW - Confidence intervals KW - Splines KW - Sulfur dioxide KW - Ozone KW - Copyrights KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743478529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Season%2C+Sex%2C+Age%2C+and+Education+as+Modifiers+of+the+Effects+of+Outdoor+Air+Pollution+on+Daily+Mortality+in+Shanghai%2C+China%3A+The+Public+Health+and+Air+Pollution+in+Asia+%28PAPA%29+Study&rft.au=Kan%2C+Haidong%3BLondon%2C+Stephanie+J%3BChen%2C+Guohai%3BZhang%2C+Yunhui%3BSong%2C+Guixiang%3BZhao%2C+Naiqing%3BJiang%2C+Lili%3BChen%2C+Bingheng&rft.aulast=Kan&rft.aufirst=Haidong&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1183&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Association between 24-Hour Urinary Cadmium and Pulmonary Function among Community-Exposed Men: The VA Normative Aging Study AN - 743473635; 201004-31-0306924 (CE); 12108125 (EN) AB - BACKGROUND: High levels of cadmium exposure are known to cause emphysema in occupationally exposed workers, but little has been reported to date on the association between chronic environmental cadmium exposure and pulmonary function. OBJECTIVE: In this study we examined the association between pulmonary function and cadmium body burden in a subcohort of the Normative Aging Study, a community-based study of aging. METHODS: We examined 96 men who had cadmium measured in single 24-hr urinary specimens collected in 1994-1995 and who had one to three tests of pulmonary function between 1994 and 2002 (a total of 222 observations). We used mixed-effect models to predict pulmonary function based on individual 24-hr urinary cadmium output, adjusted for age, height, time elapsed from the baseline, and smoking status. We assessed effect modification by smoking status. RESULTS: Among all subjects, a single log-unit increase in baseline urinary cadmium was inversely associated with forced expiratory volume in 1 sec (FEV(1)) percent predicted [beta = -7.56%; 95% confidence interval (CI) -13.59% to -1.53%]; forced vital capacity (FVC) percent predicted (beta = -2.70%; 95% CI -7.39% to 1.99%), and FEV(1)/FVC ratio (beta = -4.13%; 95% CI -7.61% to -0.66%). In models including an interaction between urinary cadmium and smoking status, there was a graded, statistically significant reduction in FEV(1)/FVC ratio across smoking status in association with urinary cadmium. CONCLUSIONS: This study suggests that chronic cadmium exposure is associated with reduced pulmonary function, and cigarette smoking modifies this association. These results should be interpreted with caution because the sample size is small, and further studies are needed to confirm our findings. JF - Environmental Health Perspectives AU - Lampe, Brad J AU - Park, Sung Kyun AU - Robins, Thomas AU - Mukherjee, Bhramar AU - Litonjua, Augusto A AU - Amarasiriwardena, Chitra AU - Weisskopf, Marc AU - Sparrow, David AU - Hu, Howard PY - 2008 SP - 1226 EP - 1230 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Cadmium KW - Pulmonary functions KW - Smoking KW - Mathematical models KW - Beta KW - Health KW - Men KW - Statistical methods KW - Samples KW - Reduction KW - Emphysema KW - Cigarettes KW - Statistical analysis KW - Confidence intervals KW - Copyrights KW - Parks KW - Age KW - Adjustment KW - Exposure KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743473635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Association+between+24-Hour+Urinary+Cadmium+and+Pulmonary+Function+among+Community-Exposed+Men%3A+The+VA+Normative+Aging+Study&rft.au=Lampe%2C+Brad+J%3BPark%2C+Sung+Kyun%3BRobins%2C+Thomas%3BMukherjee%2C+Bhramar%3BLitonjua%2C+Augusto+A%3BAmarasiriwardena%2C+Chitra%3BWeisskopf%2C+Marc%3BSparrow%2C+David%3BHu%2C+Howard&rft.aulast=Lampe&rft.aufirst=Brad&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1226&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Residential Traffic and Children's Respiratory Health AN - 743441933; 201004-31-0306920 (CE); 12108118 (EN) AB - BACKGROUND: Living near traffic has been associated with asthma and other respiratory symptoms. Most studies, however, have been conducted in areas with high background levels of ambient air pollution, making it challenging to isolate an independent effect of traffic. Additionally, most investigations have used surrogates of exposure, and few have measured traffic pollutants directly as part of the study. OBJECTIVE: We conducted a cross-sectional study of current asthma and other respiratory symptoms in children (n = 1,080) living at varying distances from high-traffic roads in the San Francisco Bay Area, California, a highly urbanized region characterized by good regional air quality due to coastal breezes. METHODS: We obtained health information and home environmental factors by parental questionnaire. We assessed exposure with several measures of residential proximity to traffic calculated using geographic information systems, including traffic within a given radius and distance to major roads. We also measured traffic-related pollutants (nitrogen oxides and nitrogen dioxide) for a subset of households to determine how well traffic metrics correlated with measured traffic pollutants. RESULTS: Using multivariate logistic regression analyses, we found associations between current asthma and residential proximity to traffic. For several traffic metrics, children whose residences were in the highest quintile of exposure had approximately twice the adjusted odds of current asthma (i.e., asthma episode in the preceeding 12 months) compared with children whose residences were within the lowest quintile. The highest risks were among those living within 75 m of a freeway/highway. Most traffic metrics correlated moderately well with actual pollutant measurements. CONCLUSION: Our findings provide evidence that even in an area with good regional air quality, proximity to traffic is associated with adverse respiratory health effects in children. JF - Environmental Health Perspectives AU - Kim, Janice J AU - Huen, Karen AU - Adams, Sara AU - Smorodinsky, Svetlana AU - Hoats, Abby AU - Malig, Brian AU - Lipsett, Michael AU - Ostro, Bart PY - 2008 SP - 1274 EP - 1279 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Traffic flow KW - Traffic engineering KW - Asthma KW - Children KW - Health KW - Pollutants KW - Proximity KW - Residential KW - Roads KW - Correlation analysis KW - Air quality KW - Regional KW - Air pollution KW - Highways KW - Geographic information systems KW - Nitrogen dioxide KW - Coastal KW - Risk KW - Households KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743441933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Residential+Traffic+and+Children%27s+Respiratory+Health&rft.au=Kim%2C+Janice+J%3BHuen%2C+Karen%3BAdams%2C+Sara%3BSmorodinsky%2C+Svetlana%3BHoats%2C+Abby%3BMalig%2C+Brian%3BLipsett%2C+Michael%3BOstro%2C+Bart&rft.aulast=Kim&rft.aufirst=Janice&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1274&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Risk of Birth Defects in Australian Communities with High Levels of Brominated Disinfection By-products AN - 743426720; 201004-31-0306919 (CE); 12108117 (EN) AB - BACKGROUND: By international standards, water supplies in Perth, Western Australia, contain high trihalomethane (THM) levels, particularly the brominated forms. Geographic variability in these levels provided an opportunity to examine cross-city spatial relationships between THM exposure and rates of birth defects (BDs). OBJECTIVES: Our goal was to examine BD rates by exposure to THMs with a highly brominated fraction in metropolitan locations in Perth, Western Australia. METHODS: We collected water samples from 47 separate locations and analyzed them for total and individual THM concentrations (micrograms per liter), including separation into brominated forms. We classified collection areas by total THM (TTHM) concentration: low ( 60 microg/L), medium ( 60 to 130 microg/L), and high ( or = 130 microg/L). We also obtained deidentified registry-based data on total births and BDs (2000-2004 inclusive) from post codes corresponding to water sample collection sites and used binomial logistic regression to compare the frequency of BDs aggregately and separately for the TTHM exposure groups, adjusting for maternal age and socioeconomic status. RESULTS: Total THMs ranged from 36 to 190 microg/L. A high proportion of the THMs were brominated (on average, 92%). Women living in high-TTHM areas showed an increased risk of any BD [odds ratio (OR) = 1.22; 95% confidence interval (CI), 1.01-1.48] and for the major category of any cardiovascular BD (OR = 1.62; 95% CI, 1.04-2.51), compared with women living in low-TTHM areas. CONCLUSIONS: Brominated forms constituted the significant fraction of THMs in all areas. Small but statistically significant increases in risks of BDs were associated with residence in areas with high THMs. JF - Environmental Health Perspectives AU - Chisholm, Kimberley AU - Cook, Angus AU - Bower, Carol AU - Weinstein, Philip PY - 2008 SP - 1267 EP - 1273 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Bromination KW - Risk KW - Standards KW - Byproducts KW - Statistical methods KW - Samples KW - Western Australia KW - Statistical analysis KW - Health KW - Birth defects KW - Collection KW - Categories KW - Water supplies KW - Heating KW - Regression KW - Separation KW - Confidence intervals KW - Communities KW - Binomials KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743426720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Risk+of+Birth+Defects+in+Australian+Communities+with+High+Levels+of+Brominated+Disinfection+By-products&rft.au=Chisholm%2C+Kimberley%3BCook%2C+Angus%3BBower%2C+Carol%3BWeinstein%2C+Philip&rft.aulast=Chisholm&rft.aufirst=Kimberley&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1267&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Right Heart Pressure Increases after Acute Increases in Ambient Particulate Concentration AN - 743413092; 201004-31-0306933 (CE); 12108134 (EN) AB - OBJECTIVES: We explored the association between acute changes in daily mean pulmonary artery (PA) and right ventricular (RV) pressures and concentrations of ambient fine particulate matter [PM with aerodynamic diameter or = 2.5 microm (PM(2.5))] as an explanation for previous associations between congestive heart failure (HF) hospital admissions and PM. MATERIALS AND METHODS: In the Chronicle Offers Management to Patients with Advanced Signs and Symptoms of Heart Failure (COMPASS-HF) trial, to see whether management of ambulatory HF could be improved by providing continuous right heart pressure monitoring to physicians, the Chronicle Implantable Hemodynamic Monitor (Medtronic, Inc., Minneapolis, MN, USA) continuously measured multiple right heart hemodynamic parameters, heart rate, and activity trends in subjects with moderate/severe HF. Using these trial data, we calculated daily mean pressures, using only those time intervals where the subject was not physically active (n = 5,807 person-days; n = 11 subjects). We then studied the association between mean daily PA/RV pressures and mean ambient PM(2.5) concentrations on the same day and previous 6 days. RESULTS: Each 11.62-microg/m(3) increase in same-day mean PM(2.5) concentration was associated with small but significant increases in estimated PA diastolic pressure [0.19 mmHg; 95% confidence interval (CI), 0.05-0.33] and RV diastolic pressure (0.23 mmHg; 95% CI, 0.11-0.34). Although we saw considerable differences in the magnitude of response by COMPASS-HF randomization group (total data access for physicians vs. blocked clinician access), season, left ventricular ejection fraction, and obesity, these effects were not significantly different. CONCLUSIONS: These pilot study findings provide a potential mechanism for previous findings of increased risk of HF associated with ambient PM. However, because of the small number of subjects, a larger study is needed for confirmation. JF - Environmental Health Perspectives AU - Rich, David Q AU - Freudenberger, Ronald S AU - Ohman-Strickland, Pamela AU - Cho, Yong AU - Kipen, Howard M PY - 2008 SP - 1167 EP - 1171 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Heart KW - Recreational vehicles KW - Failure KW - Compasses KW - Health KW - Hemodynamics KW - Diastolic pressure KW - Management KW - Physicians KW - Heart rate KW - Monitors KW - Risk KW - Arteries KW - Patients KW - Intervals KW - Ejection KW - Seasons KW - Mathematical analysis KW - Hospitals KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743413092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Right+Heart+Pressure+Increases+after+Acute+Increases+in+Ambient+Particulate+Concentration&rft.au=Rich%2C+David+Q%3BFreudenberger%2C+Ronald+S%3BOhman-Strickland%2C+Pamela%3BCho%2C+Yong%3BKipen%2C+Howard+M&rft.aulast=Rich&rft.aufirst=David&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1167&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Oridonin Confers Protection against Arsenic-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response AN - 743411905; 201004-31-0306934 (CE); 12108135 (EN) AB - BACKGROUND: Groundwater contaminated with arsenic imposes a big challenge to human health worldwide. Using natural compounds to subvert the detrimental effects of arsenic represents an attractive strategy. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical regulator of the cellular antioxidant response and xenobiotic metabolism. Recently, activation of the Nrf2 signaling pathway has been reported to confer protection against arsenic-induced toxicity in a cell culture model. OBJECTIVES: The goal of the present work was to identify a potent Nrf2 activator from plants as a chemopreventive compound and to demonstrate the efficacy of the compound in battling arsenic-induced toxicity. RESULTS: Oridonin activated the Nrf2 signaling pathway at a low subtoxic dose and was able to stabilize Nrf2 by blocking Nrf2 ubiquitination and degradation, leading to accumulation of the Nrf2 protein and activation of the Nrf2-dependent cytoprotective response. Pretreatment of UROtsa cells with 1.4 muM oridonin significantly enhanced the cellular redox capacity, reduced formation of reactive oxygen species (ROS), and improved cell survival after arsenic challenge. CONCLUSIONS: We identified oridonin as representing a novel class of Nrf2 activators and illustrated the mechanism by which the Nrf2 pathway is activated. Furthermore, we demonstrated the feasibility of using natural compounds targeting Nrf2 as a therapeutic approach to protect humans from various environmental insults that may occur daily. JF - Environmental Health Perspectives AU - Du, Yu AU - Villaneuva, Nicole F AU - Wang, Xiao-Jun AU - Sun, Zheng AU - Chen, Weimin AU - Li, Jixue AU - Lou, Hongxiang AU - Wong, Pak Kin AU - Zhang, Donna D PY - 2008 SP - 1154 EP - 1161 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Arsenic KW - Activation KW - Toxicity KW - Health KW - Mathematical models KW - Pathways KW - Cellular KW - Activated KW - Human KW - Degradation KW - Culture KW - Sun KW - Strategy KW - Antioxidants KW - Groundwater KW - Copyrights KW - Regulators KW - Pretreatment KW - Metabolism KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743411905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Oridonin+Confers+Protection+against+Arsenic-Induced+Toxicity+through+Activation+of+the+Nrf2-Mediated+Defensive+Response&rft.au=Du%2C+Yu%3BVillaneuva%2C+Nicole+F%3BWang%2C+Xiao-Jun%3BSun%2C+Zheng%3BChen%2C+Weimin%3BLi%2C+Jixue%3BLou%2C+Hongxiang%3BWong%2C+Pak+Kin%3BZhang%2C+Donna+D&rft.aulast=Du&rft.aufirst=Yu&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1154&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Public Health and Air Pollution in Asia (PAPA): A Multicity Study of Short-Term Effects of Air Pollution on Mortality AN - 743365375; 201004-31-0306927 (CE); 12108128 (EN) AB - BACKGROUND AND OBJECTIVES: Although the deleterious effects of air pollution from fossil fuel combustion have been demonstrated in many Western nations, fewer studies have been conducted in Asia. The Public Health and Air Pollution in Asia (PAPA) project assessed the effects of short-term exposure to air pollution on daily mortality in Bangkok, Thailand, and in three cities in China: Hong Kong, Shanghai, and Wuhan. METHODS: Poisson regression models incorporating natural spline smoothing functions were used to adjust for seasonality and other time-varying covariates that might confound the association between air pollution and mortality. Effect estimates were determined for each city and then for the cities combined using a random effects method. RESULTS: In individual cities, associations were detected between most of the pollutants [nitrogen dioxide, sulfur dioxide, particulate matter or = 10 microm in aerodynamic diameter (PM(10)), and ozone] and most health outcomes under study (i.e., all natural-cause, cardiovascular, and respiratory mortality). The city-combined effects of the four pollutants tended to be equal or greater than those identified in studies conducted in Western industrial nations. In addition, residents of Asian cities are likely to have higher exposures to air pollution than those in Western industrial nations because they spend more time outdoors and less time in air conditioning. CONCLUSIONS: Although the social and environmental conditions may be quite different, it is reasonable to apply estimates derived from previous health effect of air pollution studies in the West to Asia. JF - Environmental Health Perspectives AU - Wong, Chit-Ming AU - Vichit-Vadakan, Nuntavarn AU - Kan, Haidong AU - Qian, Zhegmin PY - 2008 SP - 1195 EP - 1202 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Air pollution KW - Mortality KW - Health KW - Nations KW - Mathematical models KW - Estimates KW - Public health KW - Pollutants KW - Combustion KW - Nitrogen dioxide KW - Air conditioning KW - Regression KW - Splines KW - Sulfur dioxide KW - Ozone KW - Copyrights KW - Smoothing KW - Aerodynamics KW - Adjustment KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743365375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Public+Health+and+Air+Pollution+in+Asia+%28PAPA%29%3A+A+Multicity+Study+of+Short-Term+Effects+of+Air+Pollution+on+Mortality&rft.au=Wong%2C+Chit-Ming%3BVichit-Vadakan%2C+Nuntavarn%3BKan%2C+Haidong%3BQian%2C+Zhegmin&rft.aulast=Wong&rft.aufirst=Chit-Ming&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1195&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens AN - 743356004; 201004-31-0306926 (CE); 12108127 (EN) AB - BACKGROUND: Concerns have been raised about the biological and toxicologic effects of the antimicrobials triclocarban (TCC) and triclosan (TCS) in personal care products. Few studies have evaluated their biological activities in mammalian cells to assess their potential for adverse effects. OBJECTIVES: In this study, we assessed the activity of TCC, its analogs, and TCS in in vitro nuclear-receptor-responsive and calcium signaling bioassays. MATERIALS AND METHODS: We determined the biological activities of the compounds in in vitro, cell-based, and nuclear-receptor-responsive bioassays for receptors for aryl hydrocarbon (AhR), estrogen (ER), androgen (AR), and ryanodine (RyR1). RESULTS: Some carbanilide compounds, including TCC (1-10 muM), enhanced estradiol (E(2))-dependent or testosterone-dependent activation of ER- and AR-responsive gene expression up to 2.5-fold but exhibited little or no agonistic activity alone. Some carbanilides and TCS exhibited weak agonistic and/or antagonistic activity in the AhR-responsive bioassay. TCS exhibited antagonistic activity in both ER- and AR-responsive bioassays. TCS (0.1-10 muM) significantly enhanced the binding of [(3)H]ryanodine to RyR1 and caused elevation of resting cytosolic [Ca(2+)] in primary skeletal myotubes, but carbanilides had no effect. CONCLUSIONS: Carbanilides, including TCC, enhanced hormone-dependent induction of ER- and AR-dependent gene expression but had little agonist activity, suggesting a new mechanism of action of endocrine-disrupting compounds. TCS, structurally similar to noncoplanar ortho-substituted poly-chlorinated biphenyls, exhibited weak AhR activity but interacted with RyR1 and stimulated Ca(2+) mobilization. These observations have potential implications for human and animal health. Further investigations are needed into the biological and toxicologic effects of TCC, its analogs, and TCS. JF - Environmental Health Perspectives AU - Ahn, Ki Chang AU - Zhao, Bin AU - Chen, Jiangang AU - Cherednichenko, Gennady AU - Sanmarti, Enio AU - Denison, Michael S AU - Lasley, Bill AU - Pessah, Isaac N AU - Kueltz, Dietmar AU - Chang, Daniel P Y AU - Gee, Shirley J AU - Hammock, Bruce D PY - 2008 SP - 1203 EP - 1210 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Bioassay KW - Biological KW - In vitro testing KW - Analogs KW - Gene expression KW - Health KW - Screens KW - Activation KW - Binding KW - Animal health KW - Aromatic compounds KW - Estrogens KW - Bills KW - Receptors KW - Calcium KW - Hydrocarbons KW - Copyrights KW - Elevation KW - Human KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743356004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=In+Vitro+Biologic+Activities+of+the+Antimicrobials+Triclocarban%2C+Its+Analogs%2C+and+Triclosan+in+Bioassay+Screens%3A+Receptor-Based+Bioassay+Screens&rft.au=Ahn%2C+Ki+Chang%3BZhao%2C+Bin%3BChen%2C+Jiangang%3BCherednichenko%2C+Gennady%3BSanmarti%2C+Enio%3BDenison%2C+Michael+S%3BLasley%2C+Bill%3BPessah%2C+Isaac+N%3BKueltz%2C+Dietmar%3BChang%2C+Daniel+P+Y%3BGee%2C+Shirley+J%3BHammock%2C+Bruce+D&rft.aulast=Ahn&rft.aufirst=Ki&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1203&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Environmental Public Health Tracking of Childhood Asthma Using California Health Interview Survey, Traffic, and Outdoor Air Pollution Data AN - 743355692; 201004-31-0306917 (CE); 12108115 (EN) AB - BACKGROUND: Despite extensive evidence that air pollution affects childhood asthma, state-level and national-level tracking of asthma outcomes in relation to air pollution is limited. OBJECTIVES: Our goals were to evaluate the feasibility of linking the 2001 California Health Interview Survey (CHIS), air monitoring, and traffic data; estimate associations between traffic density (TD) or outdoor air pollutant concentrations and childhood asthma morbidity; and evaluate the usefulness of such databases, linkages, and analyses to Environmental Public Health Tracking (EPHT). METHODS: We estimated TD within 500 feet of residential cross-streets of respondents and annual average pollutant concentrations based on monitoring station measurements. We used logistic regression to examine associations with reported asthma symptoms and emergency department (ED) visits/hospitalizations. RESULTS: Assignment of TD and air pollution exposures for cross-streets was successful for 82% of children with asthma in Los Angeles and San Diego, California, Counties. Children with asthma living in high ozone areas and areas with high concentrations of particulate matter 10 microm in aerodynamic diameter experienced symptoms more frequently, and those living close to heavy traffic reported more ED visits/hospitalizations. The advantages of the CHIS for asthma EPHT include a large and representative sample, biennial data collection, and ascertainment of important socio-demographic and residential address information. Disadvantages are its cross-sectional design, reliance on parental reports of diagnoses and symptoms, and lack of information on some potential confounders. CONCLUSIONS: Despite limitations, the CHIS provides a useful framework for examining air pollution and childhood asthma morbidity in support of EPHT, especially because later surveys address some noted gaps. We plan to employ CHIS 2003 and 2005 data and novel exposure assessment methods to re-examine the questions raised here. JF - Environmental Health Perspectives AU - Wilhelm, Michelle AU - Meng, Ying-Ying AU - Rull, Rudolph P AU - English, Paul AU - Balmes, John AU - Ritz, Beate PY - 2008 SP - 1254 EP - 1260 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Asthma KW - Air pollution KW - Traffic flow KW - Traffic engineering KW - Health KW - Tracking KW - Children KW - Public health KW - Pollutants KW - Residential KW - Exposure KW - Density KW - Outdoor KW - Assessments KW - Emergencies KW - Regression KW - Feet KW - Estimates KW - Regression analysis KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743355692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Environmental+Public+Health+Tracking+of+Childhood+Asthma+Using+California+Health+Interview+Survey%2C+Traffic%2C+and+Outdoor+Air+Pollution+Data&rft.au=Wilhelm%2C+Michelle%3BMeng%2C+Ying-Ying%3BRull%2C+Rudolph+P%3BEnglish%2C+Paul%3BBalmes%2C+John%3BRitz%2C+Beate&rft.aulast=Wilhelm&rft.aufirst=Michelle&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1254&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Enduring Mental Health Morbidity and Social Function Impairment in World Trade Center Rescue, Recovery, and Cleanup Workers: The Psychological Dimension of an Environmental Health Disaster AN - 743318457; 201004-31-0306916 (CE); 12108114 (EN) AB - BACKGROUND: The World Trade Center (WTC) attacks exposed thousands of workers to hazardous environmental conditions and psychological trauma. In 2002, to assess the health of these workers, Congress directed the National Institute for Occupational Safety and Health to establish the WTC Medical Monitoring and Treatment Program. This program has established a large cohort of WTC rescue, recovery, and cleanup workers. We previously documented extensive pulmonary dysfunction in this cohort related to toxic environmental exposures. OBJECTIVES: Our objective in this study was to describe mental health outcomes, social function impairment, and psychiatric comorbidity in the WTC worker cohort, as well as perceived symptomatology in workers' children. METHODS: Ten to 61 months after the WTC attack, 10,132 WTC workers completed a self-administered mental health questionnaire. RESULTS: Of the workers who completd the questionnaire, 11.1% met criteria for probable post-traumatic stress disorder (PTSD), 8.8% met criteria for probable depression, 5.0% met criteria for probable panic disorder, and 62% met criteria for substantial stress reaction. PTSD prevalence was comparable to that seen in returning Afghanistan war veterans and was much higher than in the U.S. general population. Point prevalence declined from 13.5% to 9.7% over the 5 years of observation. Comorbidity was extensive and included extremely high risks for impairment of social function. PTSD was significantly associated with loss of family members and friends, disruption of family, work, and social life, and higher rates of behavioral symptoms in children of workers. CONCLUSIONS: Working in 9/11 recovery operations is associated with chronic impairment of mental health and social functioning. Psychological distress and psychopathology in WTC workers greatly exceed population norms. Surveillance and treatment programs continue to be needed. JF - Environmental Health Perspectives AU - Stellman, Jeanne Mager AU - Smith, Rebecca P AU - Katz, Craig L AU - Sharma, Vansh AU - Charney, Dennis S AU - Herbert, Robin AU - Moline, Jacqueline AU - Luft, Benjamin J AU - Markowitz, Steven AU - Udasin, Iris AU - Harrison, Denise AU - Baron, Sherry AU - Landrigan, Philip J AU - Levin, Stephen M AU - Southwick, Steven PY - 2008 SP - 1248 EP - 1253 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Impairment KW - Criteria KW - Mental health KW - Recovery KW - Children KW - Disorders KW - Cleaning KW - Exposure KW - Stresses KW - Disasters KW - Risk KW - Occupational safety KW - Medical KW - Panic KW - Norms KW - Toxic KW - Surveillance KW - Sherry KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743318457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Enduring+Mental+Health+Morbidity+and+Social+Function+Impairment+in+World+Trade+Center+Rescue%2C+Recovery%2C+and+Cleanup+Workers%3A+The+Psychological+Dimension+of+an+Environmental+Health+Disaster&rft.au=Stellman%2C+Jeanne+Mager%3BSmith%2C+Rebecca+P%3BKatz%2C+Craig+L%3BSharma%2C+Vansh%3BCharney%2C+Dennis+S%3BHerbert%2C+Robin%3BMoline%2C+Jacqueline%3BLuft%2C+Benjamin+J%3BMarkowitz%2C+Steven%3BUdasin%2C+Iris%3BHarrison%2C+Denise%3BBaron%2C+Sherry%3BLandrigan%2C+Philip+J%3BLevin%2C+Stephen+M%3BSouthwick%2C+Steven&rft.aulast=Stellman&rft.aufirst=Jeanne&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1248&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - High Temperatures Enhanced Acute Mortality Effects of Ambient Particle Pollution in the "Oven" City of Wuhan, China AN - 743231049; 201004-31-0306928 (CE); 12108129 (EN) AB - BACKGROUND: We investigated whether the effect of air pollution on daily mortality is enhanced by high temperatures in Wuhan, China, using data from 2001 to 2004. Wuhan has been called an "oven" city because of its hot summers. Approximately 4.5 million permanent residents live in the 201-km(2) core area of the city. METHOD: We used a generalized additive model to analyze pollution, mortality, and covariate data. The estimates of the interaction between high temperature and air pollution were obtained from the main effects and pollutant-temperature interaction models. RESULTS: We observed effects of consistently and statistically significant interactions between particulate matter or = 10 microm (PM(10)) and temperature on daily nonaccidental (p = 0.014), cardiovascular (p = 0.007), and cardiopulmonary (p = 0.014) mortality. The PM(10) effects were strongest on extremely high-temperature days (daily average temperature, 33.1 degrees C), less strong on extremely low-temperature days (2.2 degrees C), and weakest on normal-temperature days (18.0 degrees C). The estimates of the mean percentage of change in daily mortality per 10-mug/m(3) increase in PM(10) concentrations at the average of lags 0 and 1 day during hot temperature were 2.20% (95% confidence interval), 0.74-3.68) for nonaccidental, 3.28% (1.24-5.37) for cardiovascular, 2.35% (-0.03 to 4.78) for stroke, 3.31% (-0.22 to 6.97) for cardiac, 1.15% (-3.54% to 6.07) for respiratory, and 3.02% (1.03-5.04) for cardiopulmonary mortality. CONCLUSIONS: We found synergistic effects of PM(10) and high temperatures on daily nonaccidental, cardiovascular, and cardiopulmonary mortality in Wuhan. JF - Environmental Health Perspectives AU - Qian, Zhengmin AU - He, Qingci AU - Lin, Hung-Mo AU - Kong, Lingli AU - Bentley, Christy M AU - Liu, Wenshan AU - Zhou, Dunjin PY - 2008 SP - 1172 EP - 1178 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mortality KW - Air pollution KW - Pollution abatement KW - Estimates KW - Health KW - Confidence intervals KW - Copyrights KW - Summer KW - Synergistic effect KW - Mathematical models KW - Additives KW - Strokes KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743231049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=High+Temperatures+Enhanced+Acute+Mortality+Effects+of+Ambient+Particle+Pollution+in+the+%22Oven%22+City+of+Wuhan%2C+China&rft.au=Qian%2C+Zhengmin%3BHe%2C+Qingci%3BLin%2C+Hung-Mo%3BKong%2C+Lingli%3BBentley%2C+Christy+M%3BLiu%2C+Wenshan%3BZhou%2C+Dunjin&rft.aulast=Qian&rft.aufirst=Zhengmin&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1172&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Gene and Protein Expression following Exposure to Radiofrequency Fields from Mobile Phones AN - 743218976; 201004-31-0306937 (CE); 12108138 (EN) AB - BACKGROUND: Since 1999, several articles have been published on genome-wide and/or proteome-wide response after exposure to radiofrequency (RF) fields whose signal and intensities were similar to or typical of those of currently used mobile telephones. These studies were performed using powerful high-throughput screening techniques (HTSTs) of transcriptomics and/or proteomics, which allow for the simultaneous screening of the expression of thousands of genes or proteins. OBJECTIVES: We reviewed these HTST-based studies and compared the results with currently accepted concepts about the effects of RF fields on gene expression. In this article we also discuss these last in light of the recent concept of microwave-assisted chemistry. DISCUSSION: To date, the results of HTST-based studies of transcriptomics and/or proteomics after exposure to RF fields relevant to human exposure are still inconclusive, as most of the positive reports are flawed by methodologic imperfections or shortcomings. In addition, when positive findings were reported, no precise response pattern could be identified in a reproducible way. In particular, results from HTST studies tend to exclude the role of a cell stressor for exposure to RF fields at nonthermal intensities. However, on the basis of lessons from microwave-assisted chemistry, we can assume that RF fields might affect heat-sensitive gene or protein expression to an extent larger than would be predicted from temperature change only. But in all likelihood, this would concern intensities higher than those relevant to usual human exposure. CONCLUSIONS: The precise role of transcriptomics and proteomics in the screening of bioeffects from exposure to RF fields from mobile phones is still uncertain in view of the lack of positively identified phenotypic change and the lack of theoretical, as well as experimental, arguments for specific gene and/or protein response patterns after this kind of exposure. JF - Environmental Health Perspectives AU - Vanderstraeten, Jacques AU - Verschaeve, Luc PY - 2008 SP - 1131 EP - 1135 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Radio frequencies KW - Genes KW - Proteins KW - Screening KW - Proteomics KW - Telephones KW - Human KW - Radiofrequency KW - Health KW - Copyrights KW - Gene expression KW - Defects KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743218976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Gene+and+Protein+Expression+following+Exposure+to+Radiofrequency+Fields+from+Mobile+Phones&rft.au=Vanderstraeten%2C+Jacques%3BVerschaeve%2C+Luc&rft.aulast=Vanderstraeten&rft.aufirst=Jacques&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1131&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Fluoride Induces Endoplasmic Reticulum Stress and Inhibits Protein Synthesis and Secretion AN - 743194409; 201004-31-0306935 (CE); 12108136 (EN) AB - BACKGROUND: Exposure to excessive amounts of fluoride (F(-)) causes dental fluorosis in susceptible individuals; however, the mechanism of F(-)-induced toxicity is unclear. Previously, we have shown that high-dose F(-) activates the unfolded protein response (UPR) in ameloblasts that are responsible for dental enamel formation. The UPR is a signaling pathway responsible for either alleviating endoplasmic reticulum (ER) stress or for inducing apoptosis of the stressed cells. OBJECTIVES: In this study we determined if low-dose F(-) causes ER stress and activates the UPR, and we also determined whether F(-) interferes with the secretion of proteins from the ER. METHODS: We stably transfected the ameloblast-derived LS8 cell line with secreted alkaline phosphatase (SEAP) and determined activity and localization of SEAP and F(-)-mediated induction of UPR proteins. Also, incisors from mice given drinking water containing various concentrations of F(-) were examined for eucaryotic initiation factor-2, subunit alpha (eIF2alpha) phosphorylation. RESULTS: We found that F(-) decreases the extracellular secretion of SEAP in a linear, dose-dependent manner. We also found a corresponding increase in the intracellular accumulation of SEAP after exposure to F(-). These changes are associated with the induction of UPR proteins such as the molecular chaperone BiP and phosphorylation of the UPR sensor PKR-like ER kinase, and its substrate, eIF2alpha. Importantly, F(-)-induced phosphorylation of eIF2alphawas confirmed in vivo. CONCLUSIONS: These data suggest that F(-) initiates an ER stress response in ameloblasts that interferes with protein synthesis and secretion. Consequently, ameloblast function during enamel development may be impaired, and this may culminate in dental fluorosis. JF - Environmental Health Perspectives AU - Sharma, Ramaswamy AU - Tsuchiya, Masahiro AU - Bartlett, John D PY - 2008 SP - 1142 EP - 1146 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Secretions KW - Proteins KW - Stresses KW - Phosphorylation KW - Kinases KW - Protein synthesis KW - Fluorides KW - Health KW - Endoplasmic reticulum KW - Biocompatibility KW - Toxicity KW - Mice KW - Drinking water KW - Position (location) KW - Surgical implants KW - Apoptosis KW - Biomedical materials KW - Alkaline phosphatase KW - Dental enamels KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743194409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Fluoride+Induces+Endoplasmic+Reticulum+Stress+and+Inhibits+Protein+Synthesis+and+Secretion&rft.au=Sharma%2C+Ramaswamy%3BTsuchiya%2C+Masahiro%3BBartlett%2C+John+D&rft.aulast=Sharma&rft.aufirst=Ramaswamy&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1142&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Effects of Maternal Exposure to Di-(2-ethylhexyl) Phthalate during Fetal and/or Neonatal Periods on Atopic Dermatitis in Male Offspring AN - 743193846; 201004-31-0306936 (CE); 12108137 (EN) AB - BACKGROUND: Di-(2-ethylhexyl) phthalate (DEHP) has been widely used in polyvinyl chloride products and is ubiquitous in developed countries. Although maternal exposure to DEHP during fetal and/or neonatal periods reportedly affects reproductive and developmental systems, its effects on allergic diseases in offspring remain to be determined. OBJECTIVES: In the present study, we examined whether maternal exposure to DEHP during fetal and/or neonatal periods in NC/Nga mice affects atopic dermatitis-like skin lesions related to mite allergen in offspring. METHODS: We administered DEHP at a dose of 0, 0.8, 4, 20, or 100 microg/animal/week by intraperitoneal injection into dams during pregnancy (gestation days 0, 7, and 14) and/or lactation (postnatal days 1, 8, and 15). Eight-week-old male offspring of these treated females were injected intradermally with mite allergen into their right ears. We then evaluated clinical scores, ear thickening, histologic findings, and protein expression of eotaxin in the ear. RESULTS: Maternal exposure to a 100-microg dose of DEHP during neonatal periods, but not during fetal periods, enhanced atopic dermatitis-like skin lesions related to mite allergen in males. The results were concomitant with the enhancement of eosinophilic inflammation, mast cell degranulation, and protein expression of eotaxin in overall trend. CONCLUSION: Maternal exposure to DEHP during neonatal periods can accelerate atopic dermatitis-like skin lesions related to mite allergen in male offspring, possibly via T helper 2 (T(H)2)-dominant responses, which can be responsible, at least in part, for the recent increase in atopic dermatitis. JF - Environmental Health Perspectives AU - Yanagisawa, Rie AU - Takano, Hirohisa AU - Inoue, Ken-ichiro AU - Koike, Eiko AU - Sadakane, Kaori AU - Ichinose, Takamichi PY - 2008 SP - 1136 EP - 1141 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mites KW - Males KW - Ear KW - Lesions KW - Gestation KW - Dermatitis KW - Health KW - Proteins KW - Phthalates KW - Polyvinyl chlorides KW - Mice KW - Numerical control KW - Pregnancy KW - Allergic diseases KW - Dams KW - Thickening KW - Masts KW - Copyrights KW - Females KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743193846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Effects+of+Maternal+Exposure+to+Di-%282-ethylhexyl%29+Phthalate+during+Fetal+and%2For+Neonatal+Periods+on+Atopic+Dermatitis+in+Male+Offspring&rft.au=Yanagisawa%2C+Rie%3BTakano%2C+Hirohisa%3BInoue%2C+Ken-ichiro%3BKoike%2C+Eiko%3BSadakane%2C+Kaori%3BIchinose%2C+Takamichi&rft.aulast=Yanagisawa&rft.aufirst=Rie&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1136&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Identification of the Functional Domain of Thyroid Hormone Receptor Responsible for Polychlorinated Biphenyl-Mediated Suppression of Its Action in Vitro AN - 743174051; 201004-31-0306923 (CE); 12108124 (EN) AB - BACKGROUND: Polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins, and poly-chlorinated dibenzofurans adversely affect the health of humans and various animals. Such effects might be partially exerted through the thyroid hormone (TH) system. We previously reported that one of the hydroxylated PCB congeners suppresses TH receptor (TR)-mediated transcription by dissociating TR from the TH response element (TRE). However, the binding site of PCB within TR has not yet been identified. OBJECTIVES: We aimed to identify the functional TR domain responsible for the PCB-mediated suppression of TR action by comparing the magnitude of suppression using several representative PCB/dioxin congeners. MATERIALS AND METHODS: We generated chimeric receptors by combining TR and glucocorticoid receptor (GR) and determined receptor-mediated transcription using transient transfection-based reporter gene assays, and TR-TRE binding using electrophoretic mobility shift assays. RESULTS: Although several PCB congeners, including the hydroxylated forms, suppressed TR-mediated transcription to various degrees, 2,3,7,8-tetrachlorodibenzo-p-dioxin did not alter TR action, but 2,3,4,7,8-pentachlorodibenzofuran weakly suppressed it. The magnitude of suppression correlated with that of TR-TRE dissociation. The suppression by PCB congeners was evident from experiments using chimeric receptors containing a TR DNA-binding domain (DBD) but not a GR-DBD. CONCLUSIONS: Several nondioxin-like PCB congeners and hydroxylated PCB compounds suppress TR action by dissociating TR from TRE through interaction with TR-DBD. JF - Environmental Health Perspectives AU - Miyazaki, Wataru AU - Iwasaki, Toshiharu AU - Takeshita, Akira AU - Tohyama, Chiharu AU - Koibuchi, Noriyuki PY - 2008 SP - 1231 EP - 1236 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Circuit boards KW - Printed circuits KW - Receptors KW - Congeners KW - Health KW - In vitro testing KW - Hormones KW - Assaying KW - Binding KW - Correlation KW - Binding sites KW - Glucocorticoids KW - Genes KW - Copyrights KW - Polychlorinated biphenyls KW - Animals KW - Human KW - Dioxins KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743174051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Identification+of+the+Functional+Domain+of+Thyroid+Hormone+Receptor+Responsible+for+Polychlorinated+Biphenyl-Mediated+Suppression+of+Its+Action+in+Vitro&rft.au=Miyazaki%2C+Wataru%3BIwasaki%2C+Toshiharu%3BTakeshita%2C+Akira%3BTohyama%2C+Chiharu%3BKoibuchi%2C+Noriyuki&rft.aulast=Miyazaki&rft.aufirst=Wataru&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Bone Mineral Density Changes in Relation to Environmental PCB Exposure AN - 743099692; 201004-31-0306930 (CE); 12108131 (EN) AB - BACKGROUND: Bone toxicity has been linked to organochlorine exposure following a few notable poisoning incidents, but epidemiologic studies in populations with environmental organochlorine exposure have yielded inconsistent results. OBJECTIVES: The aim of this study was to investigate whether organochlorine exposure was associated with bone mineral density (BMD) in a population 60-81 years of age (154 males, 167 females) living near the Baltic coast, close to a river contaminated by polychlorinated biphenyls (PCBs). METHODS: We measured forearm BMD in participants using dual energy X-ray absorptiometry; and we assessed low BMD using age- and sex-standardized Z-scores. We analyzed blood samples for five dioxin-like PCBs, the three most abundant non-dioxin-like PCBs, and p,p'-dichloro-phenyldichloroethylene (p,p'-DDE). RESULTS: In males, dioxin-like chlorobiphenyl (CB)-118 was negatively associated with BMD; the odds ratio for low BMD (Z-score less than -1) was 1.06 (95% confidence interval, 1.01-1.12) per 10 pg/mL CB-118. The sum of the three most abundant non-dioxin-like PCBs was positively associated with BMD, but not with a decreased risk of low BMD. In females, CB-118 was positively associated with BMD, but this congener did not influence the risk of low BMD in women. CONCLUSIONS: Environmental organochlorine exposures experienced by this population sample since the 1930s in Sweden may have been sufficient to result in sex-specific changes in BMD. JF - Environmental Health Perspectives AU - Hodgson, Susan AU - Thomas, Laura AU - Fattore, Elena AU - Lind, P Monica AU - Alfven, Tobias AU - Hellstroem, Lennart AU - Haakansson, Helen AU - Carubelli, Grazia AU - Fanelli, Roberto AU - Jarup, Lars PY - 2008 SP - 1162 EP - 1166 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Density KW - Bones KW - Populations KW - Risk KW - Health KW - Males KW - Females KW - Minerals KW - Toxicity KW - Forearm KW - Circuit boards KW - Epidemiology KW - Confidence intervals KW - Energy use KW - Rivers KW - Congeners KW - Coastal environments KW - Copyrights KW - Polychlorinated biphenyls KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743099692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Bone+Mineral+Density+Changes+in+Relation+to+Environmental+PCB+Exposure&rft.au=Hodgson%2C+Susan%3BThomas%2C+Laura%3BFattore%2C+Elena%3BLind%2C+P+Monica%3BAlfven%2C+Tobias%3BHellstroem%2C+Lennart%3BHaakansson%2C+Helen%3BCarubelli%2C+Grazia%3BFanelli%2C+Roberto%3BJarup%2C+Lars&rft.aulast=Hodgson&rft.aufirst=Susan&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1162&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Comparison of the Faran Cylinder Model and the Weak Scattering Model for predicting the frequency dependence of backscatter from human cancellous femur in vitro. AN - 742777683; pmid-19045632 AB - This letter presents the first side-by-side comparison of the Faran Cylinder Model and the Weak Scattering Model for predicting backscatter from human femur. Both models are applied to the same dataset of frequency-dependent backscatter coefficients from 26 human femur cancellous bone samples in vitro. The Faran Cylinder Model predicts a slightly slower rate of increase of backscatter with frequency than the Weak Scattering Model, but both models are in reasonable agreement with the data and with each other, given the uncertainty in the measurements. JF - The Journal of the Acoustical Society of America AU - Wear, Keith A AU - Padilla, Frederic AU - Laugier, Pascal AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1408 EP - 1410 VL - 124 IS - 3 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Imaging, Three-Dimensional KW - Cadaver KW - Image Interpretation, Computer-Assisted KW - Synchrotrons KW - Humans KW - Fourier Analysis KW - X-Ray Microtomography KW - Femur -- ultrasonography KW - Scattering, Radiation KW - Femur -- radiography KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742777683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Comparison+of+the+Faran+Cylinder+Model+and+the+Weak+Scattering+Model+for+predicting+the+frequency+dependence+of+backscatter+from+human+cancellous+femur+in+vitro.&rft.au=Wear%2C+Keith+A%3BPadilla%2C+Frederic%3BLaugier%2C+Pascal&rft.aulast=Wear&rft.aufirst=Keith&rft.date=2008-09-01&rft.volume=124&rft.issue=3&rft.spage=1408&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Direct methods for characterizing high-intensity focused ultrasound transducers using acoustic streaming. AN - 742777074; pmid-19045669 AB - Two techniques are presented for noninvasively determining the intensity field of high-intensity focused ultrasound transducers in a liquid medium. The techniques are based upon the streaming velocity induced in the liquid by the absorbed ultrasound beam. The approaches are similar to an iterative streaming method previously reported, but the present approaches are "direct:" The differential operations of the Navier-Stokes equations are performed directly upon the experimentally measured streaming velocity, rather than through an iterative approach that minimizes the difference between a theoretical estimate of the streaming velocity and the one measured experimentally. As such, the direct methods are much faster than the iterative technique. The price paid for the increase in speed is smaller spatial coverage; the direct techniques are applicable only where accurate streaming velocity is available. Comparisons performed in the range 100-1000 W/cm(2) focal intensity showed differences between the direct methods and the iterative streaming technique to be less than 20%. Similar differences were observed in low-power comparisons with hydrophone measurements. JF - The Journal of the Acoustical Society of America AU - Myers, Matthew R AU - Hariharan, Prasanna AU - Banerjee, Rupak K AD - Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, U. S. FDA, 10903 New Hampshire Avenue, Building 62, Room 2231, Silver Spring, Maryland 20993-0002, USA. matthew.myers@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1790 EP - 1802 VL - 124 IS - 3 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Finite Element Analysis KW - Viscosity KW - Signal Processing, Computer-Assisted KW - Acoustics -- instrumentation KW - Transducers KW - Reproducibility of Results KW - Motion KW - Sound Spectrography KW - Normal Distribution KW - Algorithms KW - Time Factors KW - Ultrasonics KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742777074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Direct+methods+for+characterizing+high-intensity+focused+ultrasound+transducers+using+acoustic+streaming.&rft.au=Myers%2C+Matthew+R%3BHariharan%2C+Prasanna%3BBanerjee%2C+Rupak+K&rft.aulast=Myers&rft.aufirst=Matthew&rft.date=2008-09-01&rft.volume=124&rft.issue=3&rft.spage=1790&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Development and characterization of a blood mimicking fluid for high intensity focused ultrasound. AN - 742776259; pmid-19045670 AB - A blood mimicking fluid (BMF) has been developed for the acoustic and thermal characterizations of high intensity focused ultrasound (HIFU) ablation devices. The BMF is based on a degassed and de-ionized water solution dispersed with low density polyethylene microspheres, nylon particles, gellan gum, and glycerol. A broad range of physical parameters, including attenuation coefficient, speed of sound, viscosity, thermal conductivity, and diffusivity, were characterized as a function of temperature (20-70 degrees C). The nonlinear parameter B/A and backscatter coefficient were also measured at room temperature. Importantly, the attenuation coefficient is linearly proportional to the frequency (2-8 MHz) with a slope of about 0.2 dB cm(-1) MHz(-1) in the 20-70 degrees C range as in the case of human blood. Furthermore, sound speed and bloodlike backscattering indicate the usefulness of the BMF for ultrasound flow imaging and ultrasound-guided HIFU applications. Most of the other temperature-dependent physical parameters are also close to the reported values in human blood. These properties make it a unique HIFU research tool for developing standardized exposimetry techniques, validating numerical models, and determining the safety and efficacy of HIFU ablation devices. JF - The Journal of the Acoustical Society of America AU - Liu, Yunbo AU - Maruvada, Subha AU - King, Randy L AU - Herman, Bruce A AU - Wear, Keith A AD - Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland 20993, USA. Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1803 EP - 1810 VL - 124 IS - 3 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Scattering, Radiation KW - Humans KW - Laser-Doppler Flowmetry -- instrumentation KW - Water -- chemistry KW - Models, Biological KW - Regional Blood Flow KW - Microspheres KW - Hot Temperature KW - Polysaccharides, Bacterial -- chemistry KW - Nylons -- chemistry KW - Viscosity KW - Polyethylene -- chemistry KW - Nonlinear Dynamics KW - Ultrasonic Therapy -- instrumentation KW - Ultrasonography, Doppler, Color -- instrumentation KW - Ultrasonic Therapy -- adverse effects KW - Thermal Conductivity KW - Glycerol -- chemistry KW - Phantoms, Imaging KW - Blood KW - Acoustics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742776259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Development+and+characterization+of+a+blood+mimicking+fluid+for+high+intensity+focused+ultrasound.&rft.au=Liu%2C+Yunbo%3BMaruvada%2C+Subha%3BKing%2C+Randy+L%3BHerman%2C+Bruce+A%3BWear%2C+Keith+A&rft.aulast=Liu&rft.aufirst=Yunbo&rft.date=2008-09-01&rft.volume=124&rft.issue=3&rft.spage=1803&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Role of epidemiology in microbial risk assessment. AN - 733920411; 18608511 AB - Microbial risk assessment (MRA) is a systematic tool to evaluate the likelihood of exposure to food-borne pathogens and the resulting impact of exposure on consumer health. In addition, MRA can be used to evaluate the public health impact of intervention or control measures designed to prevent or reduce pathogens at any or all of the steps in our complex food production system. Epidemiological studies provide useful information and data for MRA. This paper discusses the use and limitations of epidemiological data in the development and validation of MRA using examples from published microbial risk assessments. JF - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment AU - Miliotis, M AU - Dennis, S AU - Buchanan, R AU - Potter, M AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA. marianna.miliotis@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1052 EP - 1057 VL - 25 IS - 9 SN - 1944-0049, 1944-0049 KW - Index Medicus KW - Food Microbiology KW - Consumer Product Safety KW - Humans KW - Environmental Exposure -- analysis KW - Risk Assessment -- methods KW - Environmental Exposure -- adverse effects KW - Disease Outbreaks KW - Foodborne Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733920411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.atitle=Role+of+epidemiology+in+microbial+risk+assessment.&rft.au=Miliotis%2C+M%3BDennis%2C+S%3BBuchanan%2C+R%3BPotter%2C+M&rft.aulast=Miliotis&rft.aufirst=M&rft.date=2008-09-01&rft.volume=25&rft.issue=9&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F02652030802056618 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-02 N1 - Date created - 2009-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/02652030802056618 ER - TY - JOUR T1 - Dynamics of pigmentation induction by repeated ultraviolet exposures: dose, dose interval and ultraviolet spectrum dependence. AN - 69630614; 18616777 AB - The dynamics of ultraviolet (UV)-induced melanogenesis have been well characterized for single UV exposures. However, our knowledge of the effects of repeated UV exposures on the development of new pigmentation is limited. To characterize the dynamics and dose dependence of pigmentation induction by repeated UV exposures using two different UV sources. A total of 40 healthy subjects participated in the study: 21 were exposed to a 5% UVB/95% UVA source and 19 were exposed to a 2% UVB/98% UVA source. Skin phototypes 2-3 were represented. Subjects were exposed one to three times per week. The minimal erythemal dose and minimal melanogenic dose of all subjects were determined, and both visual and instrumental observations of the development of pigmentation and erythema were recorded. Dark-brown pigmentation could be produced by a cumulative UV dose of 4200 J m(-2) given as 10 exposures over 5 weeks. However, comparable pigmentation could also be induced by a cumulative dose of 2900 J m(-2) given as eight exposures over 4 weeks. The lowest cumulative dose of 1900 J m(-2) given over 4 weeks produced moderate pigmentation. The 2% UVB source led to earlier and darker pigmentation than the 5% UVB source did for equally erythemogenic doses. These observations show that the dynamics of melanogenesis induced by repeated exposures depends on UV dose, dose interval and emission spectrum. They also indicate that increasing the UV dose above a certain level of cumulative exposure does not significantly increase the level of UV-induced pigmentation. JF - The British journal of dermatology AU - Miller, S A AU - Coelho, S G AU - Zmudzka, B Z AU - Bushar, H F AU - Yamaguchi, Y AU - Hearing, V J AU - Beer, J Z AD - Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA. sharona.miller@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 921 EP - 930 VL - 159 IS - 4 KW - Melanins KW - 0 KW - Index Medicus KW - Erythema -- etiology KW - Radiation Dosage KW - Skin -- radiation effects KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Dose-Response Relationship, Radiation KW - Time Factors KW - Male KW - Female KW - Ultraviolet Rays KW - Skin Pigmentation -- radiation effects KW - Melanins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69630614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+dermatology&rft.atitle=Dynamics+of+pigmentation+induction+by+repeated+ultraviolet+exposures%3A+dose%2C+dose+interval+and+ultraviolet+spectrum+dependence.&rft.au=Miller%2C+S+A%3BCoelho%2C+S+G%3BZmudzka%2C+B+Z%3BBushar%2C+H+F%3BYamaguchi%2C+Y%3BHearing%2C+V+J%3BBeer%2C+J+Z&rft.aulast=Miller&rft.aufirst=S&rft.date=2008-09-01&rft.volume=159&rft.issue=4&rft.spage=921&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+dermatology&rft.issn=1365-2133&rft_id=info:doi/10.1111%2Fj.1365-2133.2008.08708.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Photodermatol Photoimmunol Photomed. 2000 Feb;16(1):10-4 [10721858] J Invest Dermatol. 2001 Sep;117(3):678-82 [11564176] Pigment Cell Res. 2002 Apr;15(2):119-26 [11936269] Photodermatol Photoimmunol Photomed. 2002 Feb;18(1):23-8 [11982918] Photodermatol Photoimmunol Photomed. 2002 Oct;18(5):223-7 [12390662] J Invest Dermatol. 1981 May;76(5):352-5 [7229426] J Invest Dermatol. 1981 May;76(5):356-8 [7229427] Photochem Photobiol. 1982 Aug;36(2):187-91 [7122713] J Am Acad Dermatol. 1983 Nov;9(5):724-33 [6358278] Arch Dermatol. 1988 Jun;124(6):869-71 [3377516] J Invest Dermatol. 1992 Oct;99(4):468-73 [1402005] Photodermatol Photoimmunol Photomed. 1992 Apr;9(2):45-7 [1489713] Photodermatol Photoimmunol Photomed. 1994 Apr;10(2):53-6 [8043385] Contact Dermatitis. 1996 Jul;35(1):1-10 [8896947] J Invest Dermatol. 2005 Jun;124(6):1326-32 [15955111] Photodermatol Photoimmunol Photomed. 2006 Apr;22(2):59-66 [16606410] Photochem Photobiol. 2006 May-Jun;82(3):651-5 [16522135] Photodermatol Photoimmunol Photomed. 2006 Aug;22(4):193-9 [16869868] Pigment Cell Res. 2006 Dec;19(6):606-14 [17083487] Arch Dermatol Res. 2007 Apr;299(1):25-32 [17256147] Exp Dermatol. 2008 Nov;17(11):916-24 [18363705] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2133.2008.08708.x ER - TY - JOUR T1 - Modeling the physiological state of the inoculum and CO2 atmosphere on the lag phase and growth rate of Listeria monocytogenes. AN - 69597015; 18810878 AB - In previous studies, the growth of L. monocytogenes has been modeled under different CO2 headspace concentrations; however, the inoculum cells were always in the stationary phase. In this study, the growth of L. monocytogenes under different CO2 concentrations as affected by the physiological state of the cells was investigated. Exponential-growth-phase, stationary-phase, dried, and starved cells were prepared and inoculated at 5 degrees C into brain heart infusion broths that had been preequilibrated under atmospheres of 0, 20, 40, 60, or 80% CO2 (the balance was N2). Lag-phase duration times (LDTs) and exponential growth rates were determined by enumerating cells at appropriate time intervals and by fitting the data to a three-phase linear function that has a lag period before the initiation of exponential growth. Longer LDTs were observed as the CO2 concentration increased, with no growth observed at 80% CO2. For example, the LDTs for exponential-phase, stationary-phase, starved, and dried cells were 2.21, 8.27, 9.17, and 9.67 days, respectively, under the 40% CO2 atmosphere. In general, exponential-growth-phase cells had the shortest LDT followed by starved cells and stationary-phase cells. Dried cells had the longest LDT. Exponential growth rates decreased as the CO2 concentrations increased. Once exponential growth was attained, no retained differences among the various initial physiological states of the cells for any of the atmospheres were observed in the exponential growth rates. The exponential growth rates under 0, 20, 40, 60, and 80% CO2 averaged 0.39, 0.37, 0.23, 0.23, and 0.0 log CFU/day, respectively. Dimensionless factors were calculated that describe the inhibitory action of CO2 on the LDTs and exponential growth rates for the various physiological states. JF - Journal of food protection AU - De Jesús, Antonio J AU - Whiting, Richard C AD - U.S. Food and Drug Administration, Center for Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA. antonio.dejesus@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1915 EP - 1918 VL - 71 IS - 9 SN - 0362-028X, 0362-028X KW - Carbon Dioxide KW - 142M471B3J KW - Index Medicus KW - Food Microbiology KW - Dose-Response Relationship, Drug KW - Kinetics KW - Temperature KW - Colony Count, Microbial KW - Time Factors KW - Listeria monocytogenes -- metabolism KW - Listeria monocytogenes -- growth & development KW - Carbon Dioxide -- metabolism KW - Models, Biological KW - Carbon Dioxide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69597015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Modeling+the+physiological+state+of+the+inoculum+and+CO2+atmosphere+on+the+lag+phase+and+growth+rate+of+Listeria+monocytogenes.&rft.au=De+Jes%C3%BAs%2C+Antonio+J%3BWhiting%2C+Richard+C&rft.aulast=De+Jes%C3%BAs&rft.aufirst=Antonio&rft.date=2008-09-01&rft.volume=71&rft.issue=9&rft.spage=1915&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detection of abrin in food using enzyme-linked immunosorbent assay and electrochemiluminescence technologies. AN - 69596364; 18810871 AB - Abrin is a toxic ribosome-inactivating protein present in beans of Abrus precatorius, also known as rosary peas. The possibility that abrin could be used to adulterate food has made the development of assays for the detection of abrin a priority. Rabbit-derived polyclonal antibodies and mouse monoclonal antibodies were prepared against a mixture of abrin isozymes. The specificity and cross-reactivity of the antibodies were evaluated against a challenge library of 40 grains, nuts, legumes, and foods. An enzyme-linked immunosorbent assay (ELISA) and an electrochemiluminescence (ECL)-based assay were assembled and optimized. Polyclonal (capture) and polyclonal (detection) ELISAs, polyclonal and monoclonal ELISAs, and polyclonal and monoclonal ECL assays had limits of detection (LODs) of 0.1 to 0.5 ng/ml for abrin in buffer. The LOD for abrin dissolved into juices, dairy products, soda, chocolate drink, and condiments and analyzed with the ECL assay ranged from 0.1 to 0.5 ng/ml in the analytical sample. In contrast, the LODs for the ELISAs ranged from 0.5 to 10 ng/ml in the analytical sample. JF - Journal of food protection AU - Garber, Eric A E AU - Walker, Jennifer L AU - O'Brien, Thomas W AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Maryland 20740, USA. eric.garber@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1868 EP - 1874 VL - 71 IS - 9 SN - 0362-028X, 0362-028X KW - Antibodies, Monoclonal KW - 0 KW - Abrin KW - 1393-62-0 KW - Index Medicus KW - Sensitivity and Specificity KW - Consumer Product Safety KW - Humans KW - Cross Reactions KW - Luminescent Measurements -- methods KW - Food Analysis -- methods KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Food Contamination -- analysis KW - Abrin -- isolation & purification KW - Abrin -- analysis KW - Abrus -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69596364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Detection+of+abrin+in+food+using+enzyme-linked+immunosorbent+assay+and+electrochemiluminescence+technologies.&rft.au=Garber%2C+Eric+A+E%3BWalker%2C+Jennifer+L%3BO%27Brien%2C+Thomas+W&rft.aulast=Garber&rft.aufirst=Eric+A&rft.date=2008-09-01&rft.volume=71&rft.issue=9&rft.spage=1868&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicity and detection of ricin and abrin in beverages. AN - 69588229; 18810872 AB - The oral and intraperitoneal (i.p.) toxicities to female BALB/c mice of ricin and abrin in phosphate-buffered saline (PBS), spring water, apple juice, and half-and-half (only oral) were examined after brief (2 h) and prolonged (11 to 13 days) storage. The ricin and abrin samples prepared in PBS had oral toxicities consistent with those previous studies, indicating oral and i.p. 50% lethal doses of > 1 mg/kg of body weight and between 2 and 20 microg/kg of body weight, respectively. The toxicities of ricin and abrin in PBS were greater than those in apple juice and water. The oral toxicity of ricin and abrin in half-and-half appeared comparable to or less than that observed for the toxins in water. Spiked samples stored for a maximum of 11 days (13 for the abrin samples) at 4 degrees C induced similar numbers of fatalities as did samples stored for only 2 h. Enzyme-linked immunosorbent assays of the samples administered by i.p. injection indicated a decrease in detectable toxin at 0.5 microg/ml. JF - Journal of food protection AU - Garber, Eric A E AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Maryland 20740, USA. eric.garber@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1875 EP - 1883 VL - 71 IS - 9 SN - 0362-028X, 0362-028X KW - Abrin KW - 1393-62-0 KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - Administration, Oral KW - Injections, Intraperitoneal KW - Animals KW - Random Allocation KW - Dose-Response Relationship, Drug KW - Humans KW - Temperature KW - Biological Assay KW - Mice KW - Mice, Inbred BALB C KW - Malus -- chemistry KW - Lethal Dose 50 KW - Time Factors KW - Milk -- chemistry KW - Female KW - Ricin -- toxicity KW - Ricin -- analysis KW - Consumer Product Safety KW - Beverages -- analysis KW - Abrin -- toxicity KW - Food Contamination -- analysis KW - Abrin -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69588229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Toxicity+and+detection+of+ricin+and+abrin+in+beverages.&rft.au=Garber%2C+Eric+A+E&rft.aulast=Garber&rft.aufirst=Eric+A&rft.date=2008-09-01&rft.volume=71&rft.issue=9&rft.spage=1875&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Xenobiotic-activated receptors: from transcription to drug metabolism to disease. AN - 69551034; 18707139 AB - Xenobiotic-activated receptors (XARs) are a group of ligand-activated transcription factors that are evolutionally specialized to regulate genomic programs to protect the body against innumerable chemicals from the environment. XARs share unique properties, such as promiscuous ligand binding, conserved structural motifs, common protein partners, and overlapping target genes. These unique features of XARs clearly distinguish them from receptors that are activated by endogenous chemicals to regulate energy metabolism, reproduction, and growth and differentiation. XARs regulate xenobiotic metabolism and disposition by controlling the expression and induction of drug-metabolizing enzymes and transporters. Furthermore, XARs integrate a broad range of protective mechanisms, such as antioxidative response and immune/inflammatory functions, to antagonize foreign chemicals. As the primary means of xenobiotic sensing and defense, XARs are intimately involved in drug disposition, polymorphic drug clearance, drug-drug interaction, and pathogenesis of some chemically induced cancers and chronic diseases. As a consequence, some XAR characteristics have been exploited in drug development and safety evaluation of drugs and environmental carcinogens and toxicants. In this perspective, common features and recent advances in the structures, modes of action, and implications in disease and drug development of XARs are discussed. JF - Chemical research in toxicology AU - Ma, Qiang AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory DiVision, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. qam1@cdc.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1651 EP - 1671 VL - 21 IS - 9 KW - Pharmaceutical Preparations KW - 0 KW - Receptors, Cytoplasmic and Nuclear KW - Transcription Factors KW - Xenobiotics KW - Index Medicus KW - Animals KW - Humans KW - Receptors, Cytoplasmic and Nuclear -- agonists KW - Pharmaceutical Preparations -- metabolism KW - Transcription, Genetic -- drug effects KW - Disease KW - Transcription Factors -- agonists KW - Transcription Factors -- metabolism KW - Xenobiotics -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Xenobiotics -- pharmacology KW - Transcription, Genetic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69551034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Xenobiotic-activated+receptors%3A+from+transcription+to+drug+metabolism+to+disease.&rft.au=Ma%2C+Qiang&rft.aulast=Ma&rft.aufirst=Qiang&rft.date=2008-09-01&rft.volume=21&rft.issue=9&rft.spage=1651&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx800156s LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx800156s ER - TY - JOUR T1 - Characterization of new formalin-detoxified botulinum neurotoxin toxoids. AN - 69524441; 18667637 AB - Antigenicities of several formalin-detoxified botulinum neurotoxin preparations were measured by inhibition and sandwich enzyme-linked immunosorbent assay (ELISA), and immunogenicity was studied in mice. The toxoids were derived primarily from the serotype A 150-kDa neurotoxin protein, while one toxoid was derived from the naturally occurring 900-kDa toxin-hemagglutinin complex. Antigenicity was severely compromised in two commercially available toxoids. A variety of new toxoids were synthesized in-house by optimizing formaldehyde reaction conditions. Three of the resulting toxoids were found to be antigenically identical to the native toxin, as measured by inhibition ELISA, in spite of showing a reduction of toxicity by more than 100,000-fold. Sandwich ELISAs indicated that the in-house toxoids were two- to threefold less antigenic than the neurotoxin compared to commercial toxoids, which were about 100-fold less antigenic. Mice were immunized twice, on day 0 and day 14. By day 28, relatively high toxin-specific immunoglobulin G (IgG) titers were detected in animals that had received any of the in-house toxoids, with greater than 99% being IgG1 and the remainder being IgG2. These immunized mice remained asymptomatic after being challenged with 50 to 1,000,000 50% lethal dose (LD(50)) units of the 900-kDa neurotoxin. In contrast, animals immunized with several different batches of commercially available toxoids did not develop measurable toxin-specific antibody titers. However, these mice survived neurotoxin challenges with 2 LD(50) units but died when challenged with 6 LD(50) units. Neutralizing titers measured from pools of sera generated with the in-house toxoid preparations ranged from 2.5 to 5 U/ml. In terms of predicting immunogenicity, inhibition ELISAs comparing each formalin toxoid to the parent toxin provided good insight for screening the new toxoids as well as for estimating their relative in vivo potencies. Inhibition ELISA data indicate that those toxoids that most closely resemble the native toxin are highly immunogenic and protective. The superior quality of these new toxoids makes them useful tools for continued use in ELISA development and for antitoxin production. JF - Clinical and vaccine immunology : CVI AU - Keller, James E AD - Division of Bacterial, Parasitic and Allergenic Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. james.keller@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1374 EP - 1379 VL - 15 IS - 9 KW - Botulinum Antitoxin KW - 0 KW - Fixatives KW - Immunoglobulin G KW - Toxoids KW - Formaldehyde KW - 1HG84L3525 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - Immunoglobulin G -- blood KW - Botulinum Antitoxin -- blood KW - Animals KW - Botulism -- prevention & control KW - Neutralization Tests KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Immunization, Secondary KW - Male KW - Survival Analysis KW - Formaldehyde -- pharmacology KW - Fixatives -- pharmacology KW - Botulinum Toxins -- immunology KW - Botulinum Toxins -- toxicity KW - Toxoids -- toxicity KW - Toxoids -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69524441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+vaccine+immunology+%3A+CVI&rft.atitle=Characterization+of+new+formalin-detoxified+botulinum+neurotoxin+toxoids.&rft.au=Keller%2C+James+E&rft.aulast=Keller&rft.aufirst=James&rft.date=2008-09-01&rft.volume=15&rft.issue=9&rft.spage=1374&rft.isbn=&rft.btitle=&rft.title=Clinical+and+vaccine+immunology+%3A+CVI&rft.issn=1556-679X&rft_id=info:doi/10.1128%2FCVI.00117-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-23 N1 - Date created - 2008-09-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Appl Toxicol. 1999 Dec;19 Suppl 1:S35-8 [10594898] Biochim Biophys Acta. 1954 Oct;15(2):307-9 [13208707] Vaccine. 2002 Jun 7;20(19-20):2556-61 [12057613] J Biol Chem. 2004 Feb 20;279(8):6235-43 [14638685] J Biol Chem. 1975 Sep 25;250(18):7435-42 [809435] Infect Immun. 1977 Apr;16(1):107-9 [326664] Infect Immun. 1977 Jun;16(3):910-4 [19355] Am J Med. 1980 Oct;69(4):567-70 [7191633] Immunology. 1958 Oct;1(4):365-72 [13610419] J Immunol. 1962 Mar;88:277-83 [13893049] J Immunol. 1963 May;90:697-702 [14054890] Bull World Health Organ. 1963;29:701-9 [14107742] Arch Biochem. 1949 Dec;24(2):270-80 [15405716] J Immunol. 1960 Apr;84:384-9 [13846070] N Engl J Med. 2006 Feb 2;354(5):462-71 [16452558] Biologicals. 2006 Sep;34(3):223-6 [16490362] J Bacteriol. 2007 Feb;189(3):818-32 [17114256] Infect Immun. 2007 Jun;75(6):3043-54 [17371853] Infect Immun. 2008 Jan;76(1):437-42 [17967862] Infect Immun. 2008 Mar;76(3):1314-8 [18070903] J Immunol Methods. 2008 Aug 20;337(1):42-8 [18571196] J Protein Chem. 1991 Aug;10(4):415-25 [1781887] Am J Med. 1984 May;76(5):794-8 [6720725] Infect Immun. 1991 Feb;59(2):625-30 [1702767] Infect Immun. 1995 Jul;63(7):2738-42 [7790092] Toxicon. 1995 Oct;33(10):1383-6 [8599190] Dev Biol Stand. 1996;87:125-34 [8854009] JAMA. 1997 Aug 6;278(5):433-5 [9244338] Ann Intern Med. 1998 Aug 1;129(3):221-8 [9696731] Infect Immun. 1998 Oct;66(10):4817-22 [9746584] J Bacteriol. 1951 Jun;61(6):751-2 [14850434] Am J Hyg. 1951 Nov;54(3):342-53 [14885154] Vaccine. 2002 May 15;20(16):2107-15 [11972980] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/CVI.00117-08 ER - TY - JOUR T1 - Tasigna for chronic and accelerated phase Philadelphia chromosome--positive chronic myelogenous leukemia resistant to or intolerant of imatinib. AN - 69494214; 18765523 AB - This Food and Drug Administration (FDA) approval report describes the data and analyses leading to the approval by the FDA of nilotinib (Tasigna, AMN-107; Novartis Pharmaceuticals Corporation), an inhibitor of Bcr-Abl tyrosine kinase, for the treatment of chronic-phase (CP) and accelerated-phase (AP) chronic myelogenous leukemia (CML) resistant to or intolerant of imatinib. The FDA approval of the efficacy and safety of nilotinib was based on the results of an ongoing single-arm, open-label, phase 2 clinical trial. The primary end point for CML-CP was unconfirmed major cytogenetic response. The efficacy end point for CML-AP was confirmed hematologic response. The major cytogenetic response rate in 232 evaluable CP patients was 40% (95% confidence interval, 33%, 46%). The hematologic response rate in 105 evaluable AP patients was 26% (95% confidence interval, 18%, 35%). The median duration of response has not been reached for both CML-CP and CML-AP responding patients. In CML-CP patients, the common serious drug-related adverse reactions were thrombocytopenia and neutropenia. In CML-AP patients, the common serious drug-related adverse reactions were thrombocytopenia, neutropenia, pneumonia, febrile neutropenia, leukopenia, intracranial hemorrhage, elevated lipase, and pyrexia. Nilotinib prolongs the QT interval and sudden deaths have been reported; these risks and appropriate risk minimization strategies are described in a boxed warning on the labeling. On October 29, 2007, the U.S. FDA granted accelerated approval to nilotinib (Tasigna) for use in the treatment of CP and AP Philadelphia chromosome positive CML in adult patients resistant to or intolerant of prior therapy that included imatinib. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Hazarika, Maitreyee AU - Jiang, Xiaoping AU - Liu, Qi AU - Lee, Shwu-Luan AU - Ramchandani, Roshni AU - Garnett, Christine AU - Orr, Micheal S AU - Sridhara, Rajeshwari AU - Booth, Brian AU - Leighton, John K AU - Timmer, William AU - Harapanhalli, Ravi AU - Dagher, Ramzi AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Office of New Drugs, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993, USA. Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 5325 EP - 5331 VL - 14 IS - 17 SN - 1078-0432, 1078-0432 KW - 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide KW - 0 KW - Antineoplastic Agents KW - Benzamides KW - Piperazines KW - Protein Kinase Inhibitors KW - Pyrimidines KW - Imatinib Mesylate KW - 8A1O1M485B KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Fusion Proteins, bcr-abl KW - EC 2.7.10.2 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Protein Kinase Inhibitors -- therapeutic use KW - Clinical Trials, Phase II as Topic KW - Humans KW - Drug Approval KW - Adult KW - Drug Resistance, Neoplasm KW - Protein-Tyrosine Kinases -- antagonists & inhibitors KW - Pyrimidines -- adverse effects KW - Pyrimidines -- therapeutic use KW - Piperazines -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69494214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Tasigna+for+chronic+and+accelerated+phase+Philadelphia+chromosome--positive+chronic+myelogenous+leukemia+resistant+to+or+intolerant+of+imatinib.&rft.au=Hazarika%2C+Maitreyee%3BJiang%2C+Xiaoping%3BLiu%2C+Qi%3BLee%2C+Shwu-Luan%3BRamchandani%2C+Roshni%3BGarnett%2C+Christine%3BOrr%2C+Micheal+S%3BSridhara%2C+Rajeshwari%3BBooth%2C+Brian%3BLeighton%2C+John+K%3BTimmer%2C+William%3BHarapanhalli%2C+Ravi%3BDagher%2C+Ramzi%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Hazarika&rft.aufirst=Maitreyee&rft.date=2008-09-01&rft.volume=14&rft.issue=17&rft.spage=5325&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-08-0308 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-03 N1 - Date created - 2008-09-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-08-0308 ER - TY - JOUR T1 - Functional role of Trp-105 of Enterococcus faecalis azoreductase (AzoA) as resolved by structural and mutational analysis. AN - 69485881; 18757799 AB - Enterococcus faecalis azoreductase (AzoA) is a very active enzyme with a broad spectrum of substrate specificity and is capable of degrading various azo dyes. The enzyme has an absolute requirement for reduced FMN, which delivers a total of four electrons from NADH to the substrate, resulting in the cleavage of the nitrogen double bond. In this study, we report the identification of amino acid residues critical for FMN binding in AzoA. FMN is stabilized by 22 amino acid residues, eight of which, Trp-105, Asn-106, Leu-107, Gly-150, Gly-151, Tyr-153, Asn-121 and Tyr-129, are involved in binding the FMN isoalloxazine ring. In silico analysis of the amino acid residues revealed that the Trp residue at position 105 of AzoA is the most likely significant contributor to the binding of FMN to the enzyme and is involved in FMN stabilization and destabilization. Site-directed mutagenesis analysis of Trp-105 was performed to determine the role of this amino acid residue in FMN binding and azo dye reductive activity. The mutant proteins were overexpressed in Escherichia coli and purified by anion-exchange and size-exclusion chromatography. The replacement of Trp-105 by the small side-chain amino acids Ala and Gly caused complete loss of both affinity for FMN and enzyme activity. Substitution of Tyr for Trp-105 did not significantly decrease the V(max) of the enzyme (22 % reduction). Substitutions with three bulky side-chain amino acids, Gln, Phe and His, produced enzymes with lower V(max) values (decreases of 68.2, 30.6 and 8.2-fold, respectively). However, these mutated enzymes maintained K(m) values similar to the wild-type enzyme. This study provides an insight into the catalytic properties of AzoA in FMN stabilization and enzyme activity. JF - Microbiology (Reading, England) AU - Chen, Huizhong AU - Xu, Haiyan AU - Kweon, Ohgew AU - Chen, Siwei AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079-9502, USA. huizhong.chen@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 2659 EP - 2667 VL - 154 SN - 1350-0872, 1350-0872 KW - Flavin Mononucleotide KW - 7N464URE7E KW - Tryptophan KW - 8DUH1N11BX KW - NADH, NADPH Oxidoreductases KW - EC 1.6.- KW - azoreductase KW - Index Medicus KW - Molecular Structure KW - Escherichia coli -- metabolism KW - Models, Molecular KW - Escherichia coli -- genetics KW - Amino Acid Sequence KW - Escherichia coli -- enzymology KW - Structure-Activity Relationship KW - Binding Sites KW - Cloning, Molecular KW - Mutagenesis, Site-Directed KW - Sequence Alignment KW - Kinetics KW - Flavin Mononucleotide -- metabolism KW - Molecular Sequence Data KW - Substrate Specificity KW - NADH, NADPH Oxidoreductases -- chemistry KW - Enterococcus faecalis -- metabolism KW - Enterococcus faecalis -- genetics KW - Enterococcus faecalis -- enzymology KW - Tryptophan -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69485881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+%28Reading%2C+England%29&rft.atitle=Functional+role+of+Trp-105+of+Enterococcus+faecalis+azoreductase+%28AzoA%29+as+resolved+by+structural+and+mutational+analysis.&rft.au=Chen%2C+Huizhong%3BXu%2C+Haiyan%3BKweon%2C+Ohgew%3BChen%2C+Siwei%3BCerniglia%2C+Carl+E&rft.aulast=Chen&rft.aufirst=Huizhong&rft.date=2008-09-01&rft.volume=154&rft.issue=&rft.spage=2659&rft.isbn=&rft.btitle=&rft.title=Microbiology+%28Reading%2C+England%29&rft.issn=13500872&rft_id=info:doi/10.1099%2Fmic.0.2008%2F019877-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-09 N1 - Date created - 2008-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1099/mic.0.2008/019877-0 ER - TY - JOUR T1 - Identifying patterns of adverse event reporting for four members of the angiotensin II receptor blockers class of drugs: revisiting the Weber effect. AN - 69469346; 18636418 AB - To evaluate the evidence for temporal reporting patterns, such as the Weber effect, in spontaneous post-marketing adverse event (AE) reports submitted to the Food and Drug Administration (FDA), for four members of the angiotensin II receptor blockers drug class (ARBs). For losartan, valsartan, irbesartan, and candesartan, we evaluated temporal trends in reporting for the total number of AE reports, serious AE reports, and direct reports from consumers or health care providers (direct reports) to FDA. Reporting patterns were considered consistent with the Weber effect when the peak occurred 2 years after US marketing and the number of reports declined thereafter. We tabulated the number of reports by year since the first report. We adjusted the total number of reports, number of serious AE reports, and number of direct reports by the number of US dispensed prescriptions. There were no clear temporal reporting patterns for the total number of reports, direct reports, or serious AE reports. We observed a consistent trend for the adjusted number of direct and serious AE reports. The adjusted number was highest in the first year and continually decreased over time for all four ARBs. For the adjusted total number of reports, the decline was not constant over time. A characteristic temporal pattern in the adjusted number of reports, in which the adjusted number was highest in the first year and declined thereafter, was identified. However, we did not observe a pattern consistent with the Weber effect for these four ARBs. JF - Pharmacoepidemiology and drug safety AU - McAdams, Mara A AU - Governale, Laura A AU - Swartz, Lynette AU - Hammad, Tarek A AU - Dal Pan, Gerald J AD - Office of Surveillance and Epidemiology, Food & Drug Administration, Silver Spring, MD 20993-0002, USA. mara.mcadams@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 882 EP - 889 VL - 17 IS - 9 KW - Angiotensin II Type 1 Receptor Blockers KW - 0 KW - Antihypertensive Agents KW - Benzimidazoles KW - Biphenyl Compounds KW - Tetrazoles KW - Valsartan KW - 80M03YXJ7I KW - Valine KW - HG18B9YRS7 KW - irbesartan KW - J0E2756Z7N KW - Losartan KW - JMS50MPO89 KW - candesartan KW - S8Q36MD2XX KW - Index Medicus KW - United States KW - Drug Approval -- methods KW - Humans KW - Antihypertensive Agents -- adverse effects KW - Time Factors KW - Benzimidazoles -- adverse effects KW - Losartan -- adverse effects KW - Adverse Drug Reaction Reporting Systems -- trends KW - Valine -- analogs & derivatives KW - Valine -- adverse effects KW - Biphenyl Compounds -- adverse effects KW - Tetrazoles -- adverse effects KW - Angiotensin II Type 1 Receptor Blockers -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69469346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Identifying+patterns+of+adverse+event+reporting+for+four+members+of+the+angiotensin+II+receptor+blockers+class+of+drugs%3A+revisiting+the+Weber+effect.&rft.au=McAdams%2C+Mara+A%3BGovernale%2C+Laura+A%3BSwartz%2C+Lynette%3BHammad%2C+Tarek+A%3BDal+Pan%2C+Gerald+J&rft.aulast=McAdams&rft.aufirst=Mara&rft.date=2008-09-01&rft.volume=17&rft.issue=9&rft.spage=882&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=1099-1557&rft_id=info:doi/10.1002%2Fpds.1633 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-27 N1 - Date created - 2008-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pds.1633 ER - TY - JOUR T1 - Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes. AN - 69466775; 18534653 AB - Single-walled carbon nanotubes (SWCNT) have been introduced into a large number of new technologies and consumer products. The combination of their exceptional features with very broad applications raised concerns regarding their potential health effects. The prime target for SWCNT toxicity is believed to be the lung where exposure may occur through inhalation, particularly in occupational settings. Our previous work has demonstrated that SWCNT cause robust inflammatory responses in rodents with very early termination of the acute phase and rapid onset of chronic fibrosis. Timely elimination of polymorphonuclear neutrophils (PMNs) through apoptosis and their subsequent clearance by macrophages is a necessary stage in the resolution of pulmonary inflammation whereby NADPH oxidase contributes to control of apoptotic cell death and clearance of PMNs. Thus, we hypothesized that NADPH oxidase may be an important regulator of the transition from the acute inflammation to the chronic fibrotic stage in response to SWCNT. To experimentally address the hypothesis, we employed NADPH oxidase-deficient mice which lack the gp91(phox) subunit of the enzymatic complex. We found that NADPH oxidase null mice responded to SWCNT exposure with a marked accumulation of PMNs and elevated levels of apoptotic cells in the lungs, production of pro-inflammatory cytokines, decreased production of the anti-inflammatory and pro-fibrotic cytokine, TGF-beta, and significantly lower levels of collagen deposition, as compared to C57BL/6 control mice. These results demonstrate a role for NADPH oxidase-derived reactive oxygen species in determining course of pulmonary response to SWCNT. JF - Toxicology and applied pharmacology AU - Shvedova, A A AU - Kisin, E R AU - Murray, A R AU - Kommineni, C AU - Castranova, V AU - Fadeel, B AU - Kagan, V E AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, WV, USA. ats1@cdc.gov Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 235 EP - 240 VL - 231 IS - 2 KW - Cytokines KW - 0 KW - Nanotubes, Carbon KW - Transforming Growth Factor beta KW - Collagen KW - 9007-34-5 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Animals KW - Collagen -- drug effects KW - Lung Diseases -- etiology KW - Cytokines -- drug effects KW - Fibrosis -- etiology KW - Collagen -- metabolism KW - Lung Diseases -- pathology KW - Mice KW - Cytokines -- metabolism KW - Fibrosis -- metabolism KW - Mice, Inbred C57BL KW - Inflammation -- etiology KW - Occupational Exposure -- adverse effects KW - Transforming Growth Factor beta -- metabolism KW - Transforming Growth Factor beta -- drug effects KW - Male KW - Inflammation -- pathology KW - Neutrophils -- metabolism KW - Neutrophils -- drug effects KW - NADPH Oxidase -- metabolism KW - Apoptosis -- drug effects KW - Lung -- drug effects KW - Lung -- pathology KW - Nanotubes, Carbon -- toxicity KW - NADPH Oxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69466775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Increased+accumulation+of+neutrophils+and+decreased+fibrosis+in+the+lung+of+NADPH+oxidase-deficient+C57BL%2F6+mice+exposed+to+carbon+nanotubes.&rft.au=Shvedova%2C+A+A%3BKisin%2C+E+R%3BMurray%2C+A+R%3BKommineni%2C+C%3BCastranova%2C+V%3BFadeel%2C+B%3BKagan%2C+V+E&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2008-09-01&rft.volume=231&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2008.04.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2008.04.018 ER - TY - JOUR T1 - Commentary: regulatory toxicology and the critical path: predicting long-term outcomes from short-term studies. AN - 69465942; 18725478 JF - Veterinary pathology AU - Jacobson-Kram, D AD - PhD, DABT, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993 (USA). david.jacobsonkram@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 707 EP - 709 VL - 45 IS - 5 SN - 0300-9858, 0300-9858 KW - Index Medicus KW - Animals KW - Humans KW - Predictive Value of Tests KW - Toxicity Tests -- methods KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69465942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+pathology&rft.atitle=Commentary%3A+regulatory+toxicology+and+the+critical+path%3A+predicting+long-term+outcomes+from+short-term+studies.&rft.au=Jacobson-Kram%2C+D&rft.aulast=Jacobson-Kram&rft.aufirst=D&rft.date=2008-09-01&rft.volume=45&rft.issue=5&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Veterinary+pathology&rft.issn=03009858&rft_id=info:doi/10.1354%2Fvp.45-5-707 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1354/vp.45-5-707 ER - TY - JOUR T1 - Eye malformations in children with heavy alcohol exposure in utero. AN - 69456621; 18571671 AB - To determine whether children who do not develop fetal alcohol syndrome (FAS) despite heavy alcohol exposure are at risk for eye abnormalities. We screened 9628 pregnant women and identified 101 women who were drinking >/= 2 oz of absolute alcohol per day and 101 nondrinking control women. We followed 43 exposed and 55 control offspring between age 4 and 9 years, performing masked standardized ophthalomologic examinations. The groups did not differ in their rates of impaired visual acuity, refractory errors, ptosis, epicanthal folds, or short palpebral fissures. Biomicroscopy examination was normal in all exposed subjects; cataracts were detected in 2 control subjects (4%) but in no exposed subjects. Arterial tortuosity was seen in 7 exposed subjects (16%) and in 8 control subjects (15%). Optic nerve hypoplasia was not detected in any subject. Previous research has found that children with FAS have a high incidence of serious ophthalmologic defects; our data indicate that the risk is limited to children with FAS and does not extend to children exposed to high levels of alcohol prenatally who do not develop FAS. Eye examinations are unlikely to clarify the diagnosis in children suspected of having alcohol-related damage. JF - The Journal of pediatrics AU - Flanigan, Elizabeth Y AU - Aros, Sofia AU - Bueno, Maria Ferraz AU - Conley, Mary AU - Troendle, James F AU - Cassorla, Fernando AU - Mills, James L AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 391 EP - 395 VL - 153 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Infant, Newborn KW - Child KW - Pregnancy KW - Child, Preschool KW - Fetal Alcohol Spectrum Disorders -- etiology KW - Infant KW - Refraction, Ocular KW - Prospective Studies KW - Risk Factors KW - Adult KW - Incidence KW - Follow-Up Studies KW - Adolescent KW - United States -- epidemiology KW - Time Factors KW - Fetal Alcohol Spectrum Disorders -- epidemiology KW - Visual Acuity KW - Male KW - Female KW - Fetal Alcohol Spectrum Disorders -- diagnosis KW - Maternal Exposure -- adverse effects KW - Eye Abnormalities -- diagnosis KW - Alcohol Drinking -- adverse effects KW - Eye Abnormalities -- epidemiology KW - Eye Abnormalities -- etiology KW - Alcohol Drinking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69456621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pediatrics&rft.atitle=Eye+malformations+in+children+with+heavy+alcohol+exposure+in+utero.&rft.au=Flanigan%2C+Elizabeth+Y%3BAros%2C+Sofia%3BBueno%2C+Maria+Ferraz%3BConley%2C+Mary%3BTroendle%2C+James+F%3BCassorla%2C+Fernando%3BMills%2C+James+L&rft.aulast=Flanigan&rft.aufirst=Elizabeth&rft.date=2008-09-01&rft.volume=153&rft.issue=3&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pediatrics&rft.issn=1097-6833&rft_id=info:doi/10.1016%2Fj.jpeds.2008.04.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-09 N1 - Date created - 2008-08-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addict Biol. 2004 Jun;9(2):153-7; discussion 159-60 [15223541] Neurobehav Toxicol Teratol. 1984 Sep-Oct;6(5):373-7 [6514101] Neuropediatrics. 1981 Feb;12(1):97-8 [6789226] J Pediatr Ophthalmol Strabismus. 1981 Jul-Aug;18(4):6-15 [7264859] Birth Defects Orig Artic Ser. 1982;18(6):651-5 [6890860] J Pediatr Ophthalmol Strabismus. 1984 Jan-Feb;21(1):8-18 [6707858] J AAPOS. 2000 Aug;4(4):200-4 [10951294] Am J Obstet Gynecol. 2007 Jul;197(1):12-25 [17618743] Eur J Ophthalmol. 2007 Jan-Feb;17(1):104-9 [17294389] Neurosci Biobehav Rev. 2007;31(2):221-9 [16908065] PLoS Med. 2006 May;3(5):e247; author reply e248 [16719552] Subst Use Misuse. 2006;41(2):183-97 [16479683] J Pediatr. 2005 Oct;147(4):473-9 [16227033] Am J Public Health. 2005 Jul;95(7):1190-9 [15933241] J AAPOS. 1999 Aug;3(4):212-20 [10477223] Eur J Ophthalmol. 1997 Jul-Sep;7(3):262-70 [9352281] J Pediatr Ophthalmol Strabismus. 1997 Jan-Feb;34(1):17-23 [9027675] Acta Paediatr. 1996 Dec;85(12):1463-8 [9001659] Alcohol Clin Exp Res. 1996 Apr;20(2):359-63 [8730230] J Pediatr Ophthalmol Strabismus. 2001 Jul-Aug;38(4):219-23 [11495309] JAMA. 1981 Jan 9;245(2):108 [7452823] Pediatrics. 1996 Jun;97(6 Pt 1):845-50 [8657525] Graefes Arch Clin Exp Ophthalmol. 1995 Mar;233(3):150-3 [7758982] Br J Ophthalmol. 1991 Sep;75(9):524-6 [1911652] J Ment Defic Res. 1990 Oct;34 ( Pt 5):429-35 [2266551] Clin Pediatr (Phila). 1990 Mar;29(3):172-4 [2306903] Surv Ophthalmol. 1987 Jan-Feb;31(4):277-84 [3107154] Neurobehav Toxicol Teratol. 1985 May-Jun;7(3):263-6 [4033867] Acta Ophthalmol Suppl. 1985;171:1-50 [2988263] Alcohol Alcohol. 2002 Jan-Feb;37(1):2-8 [11825849] J Pediatr Ophthalmol. 1976 Sep-Oct;13(5):255-8 [828202] J Am Optom Assoc. 1984 Aug;55(8):595-8 [6541235] Lancet. 1973 Jun 9;1(7815):1267-71 [4126070] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jpeds.2008.04.024 ER - TY - JOUR T1 - The critical path of warfarin dosing: finding an optimal dosing strategy using pharmacogenetics. AN - 69445467; 18714317 JF - Clinical pharmacology and therapeutics AU - Lesko, L J AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. lawrence.lesko@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 301 EP - 303 VL - 84 IS - 3 KW - Anticoagulants KW - 0 KW - Warfarin KW - 5Q7ZVV76EI KW - CYP2C9 protein, human KW - EC 1.14.13.- KW - Cytochrome P-450 CYP2C9 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Abridged Index Medicus KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Cost-Benefit Analysis KW - Aged KW - Genetic Testing -- economics KW - Anticoagulants -- therapeutic use KW - Anticoagulants -- adverse effects KW - Warfarin -- adverse effects KW - Warfarin -- administration & dosage KW - Warfarin -- therapeutic use KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Pharmacogenetics KW - Anticoagulants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69445467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=The+critical+path+of+warfarin+dosing%3A+finding+an+optimal+dosing+strategy+using+pharmacogenetics.&rft.au=Lesko%2C+L+J&rft.aulast=Lesko&rft.aufirst=L&rft.date=2008-09-01&rft.volume=84&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.133 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Pharmacol Ther. 2008 Sep;84(3):303-5 [18714318] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2008.133 ER - TY - JOUR T1 - Multiendpoint mechanistic profiling of hepatotoxicants in HepG2/C3A human hepatoma cells and novel statistical approaches for development of a prediction model for acute hepatotoxicity. AN - 69439953; 18539427 AB - HepG2/C3A human hepatoma cells were exposed to serial concentrations of seven known hepatotoxicants for 48h. Six endpoint assays were selected to model different mechanisms of acute hepatotoxicity. Each compound produced a unique concentration-response pattern across all endpoints. The endpoints did not correlate strongly, suggesting that each endpoint monitored an independent cellular process. Prediction models were developed using five statistical methods. The models used only known hepatotoxicants for the training set. The zero concentration (control) and all concentrations not significantly different from control were programmed as non-toxic levels and concentrations significantly different from control as toxic levels. So, rather than a binary classification of each compound (i.e., toxic or non-toxic), the models gave a prediction of the concentration, if any, at which a compound showed behavior similar to liver toxicants at their toxic concentrations. The discriminant analysis model gave the best overall performance with positive and negative predictive values of 1.00 and 0.83, respectively. Ten additional compounds were tested using this prediction model. The model predicted liver active concentrations for each compound that were consistent with their known biologically active concentrations. This model system may be useful for predicting concentration levels at which unknown compounds would display undesirable liver activity. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Flynn, Thomas J AU - Ferguson, Martine S AD - FDA Center for Food Safety and Applied Nutrition, Division of Toxicology, U.S. Food and Drug Administration, MOD-1 Laboratories, 8301 Muirkirk Road, Laurel, MD 20708-2476, USA. thomas.flynn@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1618 EP - 1631 VL - 22 IS - 6 SN - 0887-2333, 0887-2333 KW - Xenobiotics KW - 0 KW - Index Medicus KW - Liver Neoplasms -- metabolism KW - Discriminant Analysis KW - Forecasting -- methods KW - Endpoint Determination -- methods KW - Dose-Response Relationship, Drug KW - Humans KW - Models, Statistical KW - Cell Line, Tumor KW - Xenobiotics -- administration & dosage KW - Chemical and Drug Induced Liver Injury KW - Toxicity Tests, Acute -- methods KW - Xenobiotics -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69439953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Multiendpoint+mechanistic+profiling+of+hepatotoxicants+in+HepG2%2FC3A+human+hepatoma+cells+and+novel+statistical+approaches+for+development+of+a+prediction+model+for+acute+hepatotoxicity.&rft.au=Flynn%2C+Thomas+J%3BFerguson%2C+Martine+S&rft.aulast=Flynn&rft.aufirst=Thomas&rft.date=2008-09-01&rft.volume=22&rft.issue=6&rft.spage=1618&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=08872333&rft_id=info:doi/10.1016%2Fj.tiv.2008.04.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-21 N1 - Date created - 2008-08-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tiv.2008.04.016 ER - TY - JOUR T1 - Effects of (-)-epigallocatechin gallate on the redox reactions of human hemoglobin. AN - 69413039; 18539156 AB - The toxicity of acellular hemoglobin (Hb)-based therapeutics has been attributed in part to the uncontrolled oxidative reactions. A variety of antioxidant strategies to ameliorate potential oxidative damage in vivo have been suggested. We have examined the effects of (-)-epigallocatechin gallate (EGCG), a green tea polyphenol compound widely regarded as a chain-breaking antioxidant, on the oxidative stability of diaspirin crosslinked Hb (DBBF) and its cytotoxic ferryl intermediate. DBBF (ferrous) was rapidly oxidized to the ferric form in the presence of EGCG relative to the normal spontaneous oxidation of this Hb. The fast elimination of ferrous Hb is probably due to the ability of EGCG to produce hydrogen peroxide (H2O2) as these reactions were almost completely reversed by the addition of catalase and superoxide dismutase to the reaction medium. EGCG, however, effectively reduced ferryl back to ferric Hb in a biphasic kinetic reaction at physiological pH. At acidic pH where the autoreduction of protonated ferryl Hb is enhanced, a monophasic reduction process of the ferryl heme is achieved. A balance between pro and antioxidant properties of EGCG should be taken into account if EGCG is used in combination therapy with redox active acellular Hbs. JF - Free radical biology & medicine AU - Jia, Yiping AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health Campus, Bethesda, MD 20892, USA. yiping.jia@fda.hhs.gov Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 659 EP - 666 VL - 45 IS - 5 SN - 0891-5849, 0891-5849 KW - Cross-Linking Reagents KW - 0 KW - Hemoglobins KW - succinyldisalicylic acid KW - 578-19-8 KW - Catechin KW - 8R1V1STN48 KW - epigallocatechin gallate KW - BQM438CTEL KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Cross-Linking Reagents -- chemistry KW - Oxidation-Reduction -- drug effects KW - Aspirin -- chemistry KW - Humans KW - Aspirin -- analogs & derivatives KW - Hemoglobins -- metabolism KW - Catechin -- analogs & derivatives KW - Hemoglobins -- chemistry KW - Catechin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69413039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Effects+of+%28-%29-epigallocatechin+gallate+on+the+redox+reactions+of+human+hemoglobin.&rft.au=Jia%2C+Yiping%3BAlayash%2C+Abdu+I&rft.aulast=Jia&rft.aufirst=Yiping&rft.date=2008-09-01&rft.volume=45&rft.issue=5&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2008.05.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-03 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.05.010 ER - TY - JOUR T1 - Characteristics of US workers whose blood lead levels trigger the medical removal protection provision, and conformity with biological monitoring requirements, 2003-2005. AN - 69406212; 18561249 AB - Workers with blood lead levels (BLL) > or =60 microg/dl (50 microg/dl for construction workers) or with three or more consecutive BLLs over at least 6 months that average 50 microg/dl or greater are required to be removed from work involving lead exposure that exceeds the OSHA action level. This study estimates the proportion of workers with BLLs that trigger the medical removal provision by industry sector, and examines whether workers received appropriate follow-up blood lead testing. Three years (2003-2005) of data from the Adult Blood Lead Epidemiology and Surveillance program were analyzed to identify those industries with a high percentage of workers with BLLs that trigger the medical removal provision. Adjusted rate ratios (RR) of adults with such BLLs were estimated by industry sector compared to the battery manufacturing industry using Poisson regression models. Out of 13,724 adults with BLLs > or =25 microg/dl, a total of 533 adults had BLLs that triggered the medical removal provision. RRs of adults with BLLs triggering medical removal were highest for "painting and wall covering contractors" (RR = 22.1) followed by "highway, street and bridge construction" (RR = 14.7), "amusement, gambling, and recreation" (RR = 11.4), and "glass product manufacturing" (RR = 10.1). Overall, 29% of adults with BLLs triggering medical removal received appropriate follow-up blood lead tests and met the eligibility to return to lead work. These findings suggest that additional efforts are needed to prevent occupational overexposure to lead in adults, and to ensure proper medical management of those workers who meet medical removal criteria. Published 2008 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Tak, SangWoo AU - Roscoe, Robert J AU - Alarcon, Walter AU - Ju, Jun AU - Sestito, John P AU - Sussell, Aaron L AU - Calvert, Geoffrey M AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. stak@cdc.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 691 EP - 700 VL - 51 IS - 9 KW - Lead KW - 2P299V784P KW - Index Medicus KW - United States KW - Lead Poisoning -- prevention & control KW - Guideline Adherence KW - Humans KW - Adult KW - Facility Design and Construction KW - Adolescent KW - Male KW - Female KW - Occupational Exposure KW - Environmental Monitoring KW - Occupational Health KW - Lead -- blood KW - Population Surveillance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69406212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Characteristics+of+US+workers+whose+blood+lead+levels+trigger+the+medical+removal+protection+provision%2C+and+conformity+with+biological+monitoring+requirements%2C+2003-2005.&rft.au=Tak%2C+SangWoo%3BRoscoe%2C+Robert+J%3BAlarcon%2C+Walter%3BJu%2C+Jun%3BSestito%2C+John+P%3BSussell%2C+Aaron+L%3BCalvert%2C+Geoffrey+M&rft.aulast=Tak&rft.aufirst=SangWoo&rft.date=2008-09-01&rft.volume=51&rft.issue=9&rft.spage=691&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.20603 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-12 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20603 ER - TY - JOUR T1 - Poor People, Poor Places and Access to Health Care in the United States AN - 61682884; 200905865 AB - Research suggests that community-level poverty is associated with access to health care net of individual-level characteristics, but no research investigates whether this association differs by individual-level income. Using data from the Medical Expenditure Panel Surveys, the U.S. Census Bureau and the Health Resource and Services Administration, I find that the negative relationship between the prevalence of poverty in communities and access to health care is much stronger for middle-and high-income individuals than for those in lower-income groups. I suggest that individuals may benefit from living among those in similar economic circumstances because they face similar obstacles to obtaining medical care. For poor individuals, the collective knowledge and experience embedded in poor communities may compensate for the otherwise negative influence of community-level poverty. Adapted from the source document. JF - Social Forces AU - Kirby, James B AD - AHRQ-CFACT, 540 Gaither Road, Rockville, MD 20850 jkirby@ahrq.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 325 EP - 355 PB - University of North Carolina Press, Chapel Hill VL - 87 IS - 1 SN - 0037-7732, 0037-7732 KW - Low Income Groups KW - Communities KW - United States of America KW - Access KW - Health Care Services KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61682884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Forces&rft.atitle=Poor+People%2C+Poor+Places+and+Access+to+Health+Care+in+the+United+States&rft.au=Kirby%2C+James+B&rft.aulast=Kirby&rft.aufirst=James&rft.date=2008-09-01&rft.volume=87&rft.issue=1&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Social+Forces&rft.issn=00377732&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-02-03 N1 - Number of references - 64 N1 - Last updated - 2016-09-28 N1 - CODEN - SOFOAP N1 - SubjectsTermNotLitGenreText - Low Income Groups; Health Care Services; Access; United States of America; Communities ER - TY - JOUR T1 - Benefits and Changes for Family to Family Graduates AN - 61427411; 200900537 AB - Family members of people with serious mental illnesses (SMI) need information and support to cope with the considerable stresses they experience. The Family to Family Education Program (FtF) is a structured, peer-led, 12-week information and support self-help class for such individuals. Previous research by Dixon et al. (2004) shows reduced subjective burden and increased empowerment among graduates. The present study sought to understand what processes take place during FtF participation that might lead to these benefits, as a first step in building a conceptual model of how FtF causes its effects, using semi-structured interviews with 31 FtF graduates. Qualitative data analysis suggested that new factual and emotional information from FtF shifts interviewees' understanding of their situation and that skills acquired through FtF then allow participants to incorporate these new perspectives into more adaptive behaviors. These changes led to both proximal and distal benefits for the FtF participants interviewed. The results are discussed in the context of self-help, stress-and-coping, and trauma recovery theories. Adapted from the source document. JF - American Journal of Community Psychology AU - Lucksted, Alicia AU - Stewart, Bette AU - Forbes, Courtney B AD - Center for Mental Health Services Research, Division of Services Research, Department of Psychiatry, University of Maryland School of Medicine, 737 West Lombard Street, Rm 528, Baltimore, MD 21201, USA Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 154 EP - 166 PB - Springer, Dordrecht The Netherlands VL - 42 IS - 1-2 SN - 0091-0562, 0091-0562 KW - Support KW - Stress KW - Family KW - Coping KW - Mental Illness KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61427411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Community+Psychology&rft.atitle=Benefits+and+Changes+for+Family+to+Family+Graduates&rft.au=Lucksted%2C+Alicia%3BStewart%2C+Bette%3BForbes%2C+Courtney+B&rft.aulast=Lucksted&rft.aufirst=Alicia&rft.date=2008-09-01&rft.volume=42&rft.issue=1-2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Community+Psychology&rft.issn=00910562&rft_id=info:doi/10.1007%2Fs10464-008-9195-7 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 42 N1 - Last updated - 2016-09-28 N1 - CODEN - AJCPCK N1 - SubjectsTermNotLitGenreText - Family; Mental Illness; Stress; Support; Coping DO - http://dx.doi.org/10.1007/s10464-008-9195-7 ER - TY - JOUR T1 - Evaluation of the relative importance of coalbed reservoir parameters for prediction of methane inflow rates during mining of longwall development entries AN - 50451702; 2009-075715 AB - This study presents a reservoir modeling approach to investigate the relative effects of different coalbed parameters on the migration of methane into development entries. A base coalbed reservoir model of a three-entry development section, where grids were dynamically controlled to simulate the advance of mining at a constant section advance rate, was created and calibrated for a Pittsburgh Coalbed mine in the Southwestern Pennsylvania section of the Northern Appalachian Basin. The values of coalbed parameters were varied to evaluate their effects on predicted methane emissions for various development distances. The results of these parametric simulations were then used to derive linear expressions relating these parameters to methane emissions into the workings. These models were analyzed to assess their significance and adequacy for predictive purposes. This work shows that coupling reservoir simulations with linear modeling yield a technique that can be applicable to different coalbeds. The reservoir parameters used by the linear models (coalbed thickness, pressure, sorption time constant, Langmuir parameters, permeability) can be determined by running relatively simple laboratory tests, such as adsorption equilibrium and permeability determination, on coal samples obtained either from the mining operation or from the exploratory boreholes drilled ahead of mining. JF - Computers & Geosciences AU - Karacan, C O Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1093 EP - 1114 PB - Elsevier, Amsterdam VL - 34 IS - 9 SN - 0098-3004, 0098-3004 KW - United States KW - mining KW - mines KW - migration KW - methane KW - underground mining KW - pollutants KW - statistical analysis KW - aliphatic hydrocarbons KW - prediction KW - pollution KW - coal seams KW - alkanes KW - organic compounds KW - Allegheny County Pennsylvania KW - safety KW - longwall mining KW - hydrocarbons KW - risk assessment KW - Pennsylvania KW - regression analysis KW - Pittsburgh Pennsylvania KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50451702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+%26+Geosciences&rft.atitle=Evaluation+of+the+relative+importance+of+coalbed+reservoir+parameters+for+prediction+of+methane+inflow+rates+during+mining+of+longwall+development+entries&rft.au=Karacan%2C+C+O&rft.aulast=Karacan&rft.aufirst=C&rft.date=2008-09-01&rft.volume=34&rft.issue=9&rft.spage=1093&rft.isbn=&rft.btitle=&rft.title=Computers+%26+Geosciences&rft.issn=00983004&rft_id=info:doi/10.1016%2Fj.cageo.2007.04.008 L2 - http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5840&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e5198452fad934c6346f38b57511c8e0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2009-01-01 N1 - SuppNotes - Supplemental information/data is available in the online version of this article N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; Allegheny County Pennsylvania; coal seams; hydrocarbons; longwall mining; methane; migration; mines; mining; organic compounds; Pennsylvania; Pittsburgh Pennsylvania; pollutants; pollution; prediction; regression analysis; risk assessment; safety; statistical analysis; underground mining; United States DO - http://dx.doi.org/10.1016/j.cageo.2007.04.008 ER - TY - RPRT T1 - Table of contents AN - 236501281 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236501281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-09-01&rft.volume=&rft.issue=552&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2008 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS: STUDIES OF PROPARGYL ALCOHOL (CAS NO. 107-19-7) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) AN - 236500037; 18974778 AB - Propargyl alcohol is used in a variety of chemical manufacturing processes and to protect steel from becoming brittle. We studied propargyl alcohol to determine if it caused cancer in rats or mice. We exposed groups of 50 male and female rats and mice to air containing propargyl alcohol six hours per day for two years. Rats were exposed to concentrations of 16, 32, or 64 parts per million (ppm) of propargyl alcohol in air, and mice were exposed to concentrations of 8, 16, or 32 ppm. Similar groups of 50 animals were exposed to clean air in the same inhalation chambers six hours per day as the untreated control groups. Tissues from more than 40 sites were examined for every animal. All groups of animals exposed to propargyl alcohol experienced a variety of lesions in the epithelial tissues of the nose, including hyperplasia, metaplasia, and inflammation. Adenomas of the respiratory epithelium of the nose were observed in male rats and in male and female mice exposed to propargyl alcohol. The rate of mononuclear cell leukemia was also increased in exposed male rats, and the rate of Harderian gland adenomas was increased in exposed male mice. We conclude that the increased occurrences of adenomas of the epithelium of the nose in male rats and in male and female mice and of mononuclear cell leukemia in male rats were caused by exposure to propargyl alcohol. An increased occurrence of adenomas of the Harderian gland in male mice may also have been associated with exposure to propargyl alcohol. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1 EP - 172 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Alkynes KW - Propanols KW - propargyl alcohol KW - Toxicology KW - Carcinogens KW - Rodents KW - Alcohol KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Humans KW - Carcinogenicity Tests KW - Mice KW - Neoplasms, Experimental -- pathology KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Propanols -- toxicity KW - Alkynes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236500037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS%3A+STUDIES+OF+PROPARGYL+ALCOHOL+%28CAS+NO.+107-19-7%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-09-01&rft.volume=&rft.issue=552&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2008 N1 - Document feature - Tables; Graphs; Photographs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 236440676 AB - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236440676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-09-01&rft.volume=&rft.issue=552&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2008 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Biological Enrichment of Mycoplasma Agents by Cocultivation with Permissive Cell Cultures AN - 21487652; 12494773 AB - In this study, we describe our results on the evaluation of the ability of different permissive mammalian cell lines to support the biological enrichment of mycoplasma species known to be bacterial contaminants of cell substrates. The study showed that this approach is able to significantly improve the efficiency of mycoplasma detection based on nucleic acid testing or biochemical technologies (e.g., MycoAlert mycoplasma detection). Of 10 different cell lines (Vero, MDBK, HEK-293, Hep-G2, CV-1, EBTr, WI-38, R9ab, MDCK, and High Five) used in the study, only MDCK cell culture was found to support the efficient growth of all the tested mycoplasmas (Mycoplasma arginini, M. bovis, M. fermentans, M. gallinaceum, M. gallisepticum, M. synoviae, M. hominis, M. hyorhinis, M. orale, M. salivarium, and Acholeplasma laidlawii) known to be most frequently associated with contamination of cell substrates and cell lines in research laboratories or manufacturing facilities. The infection of MDCK cells with serial dilutions of each mycoplasma species demonstrated that these common cell line contaminants can be detected reliably after 7-day enrichment in MDCK cell culture at contamination levels of 0.05 to 0.25 CFU/ml. The High Five insect cell line was also found to be able to support the efficient growth of most mycoplasma species tested, except for M. hyorhinis strain DBS1050. However, mycoplasma growth in insect cell culture was demonstrated to be temperature dependent, and the most efficient growth was observed when the incubation temperature was increased from 28C to between 35 and 37C. We believe that this type of mycoplasma enrichment is one of the most promising approaches for improving the purity and safety testing of cell substrates and other cell-derived biologics and pharmaceuticals. JF - Applied and Environmental Microbiology AU - Volokhov, Dmitriy V AU - Kong, Hyesuk AU - George, Joseph AU - Anderson, Christine AU - Chizhikov, Vladimir E Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 5383 EP - 5391 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 74 IS - 17 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Acholeplasma laidlawii KW - Cell culture KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21487652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Biological+Enrichment+of+Mycoplasma+Agents+by+Cocultivation+with+Permissive+Cell+Cultures&rft.au=Volokhov%2C+Dmitriy+V%3BKong%2C+Hyesuk%3BGeorge%2C+Joseph%3BAnderson%2C+Christine%3BChizhikov%2C+Vladimir+E&rft.aulast=Volokhov&rft.aufirst=Dmitriy&rft.date=2008-09-01&rft.volume=74&rft.issue=17&rft.spage=5383&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00720-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cell culture; Acholeplasma laidlawii DO - http://dx.doi.org/10.1128/AEM.00720-08 ER - TY - JOUR T1 - Increasing Incidence of Legionellosis in the United States, 1990-2005: Changing Epidemiologic Trends AN - 21426219; 12489756 AB - Background. An abrupt increase in the incidence of legionellosis in the United States has been noted since 2003. Whether the recent increase is associated with shifting epidemiologic trends has not been well characterized. Methods. We analyzed all cases of legionellosis reported to the Centers for Disease Control and Prevention through the National Notifiable Disease Surveillance System from 1990 through 2005. Results. A total of 23,076 cases of legionellosis were reported to the Centers for Disease Control and Prevention from 1990 through 2005. The number of reported cases increased by 70% from 1310 cases in 2002 to 2223 cases in 2003, with a sustained increase to >2000 cases per year from 2003 through 2005. The eastern United States showed most of the increases in age-adjusted incidence rates after 2002, with the mean rate in the Middle Atlantic states during 2003-2005 exceeding that during 1990-2002 by 96%. During 2000-2005, legionellosis cases were most commonly reported in persons aged 45-64 years. Persons aged <65 years comprised 63% of total cases in 2000-2005. Age-adjusted incidence rates in males exceeded those in females for all age groups and years. Legionellosis incidence showed marked seasonally in eastern states, with most cases reported in the summer or fall. Conclusions. Reported legionellosis cases have increased substantially in recent years, particularly in the eastern United States and among middle-aged adults. Legionella infection should be considered in the differential diagnosis of any patient with pneumonia. Public health professionals should focus increased attention on detection and prevention of this important and increasing public health problem. JF - Clinical Infectious Diseases AU - Neil, K AU - Berkelman, R AD - Enteric Diseases Epidemiology Branch, Div. of Foodborne, Bacterial and Mycotic Diseases, US Centers for Disease Control and Prevention, 1600 Clifton Rd., MS-A38, Atlanta, GA, 30333, USA, Karen.Neil@cdc.hhs.gov Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 591 EP - 599 VL - 47 IS - 5 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Age KW - Differential diagnosis KW - Disease control KW - Infection KW - Legionella KW - Pneumonia KW - Public health KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21426219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Increasing+Incidence+of+Legionellosis+in+the+United+States%2C+1990-2005%3A+Changing+Epidemiologic+Trends&rft.au=Neil%2C+K%3BBerkelman%2C+R&rft.aulast=Neil&rft.aufirst=K&rft.date=2008-09-01&rft.volume=47&rft.issue=5&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F590557 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; Differential diagnosis; Disease control; Infection; Pneumonia; Public health; Legionella DO - http://dx.doi.org/10.1086/590557 ER - TY - JOUR T1 - Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats AN - 20940380; 8494947 AB - 3-Monochloropropane-1,2-diol (a-chlorohydrin, 3-MCPD) is a well-known contaminant, which has been detected in a wide range of foods and ingredients, and is also a suspected cause of cancer. In this study, the carcinogenicity of 3-MCPD in SD rats was investigated. Groups of 50 male and 50 female rats were exposed for two years to drinking water containing 0, 25, 100 or 400ppm 3-MCPD. The body weights and water consumptions of the male and female rats given 400ppm 3-MCPD were significantly lower than those of the controls. The incidences of renal tubule adenomas or carcinomas and Leydig cell tumors occurred with dose-related positive trends in male rats. The incidences of renal tubule carcinomas and Leydig cell tumors were significantly increased in male rats given 400ppm 3-MCPD. The incidence of renal tubule adenomas showed a positive trend in female rats, which was significant in 400ppm 3-MCPD group. In conclusion, there was clear evidence of the carcinogenic activity of 3-MCPD in male SD rats, based on the increased incidences of renal tubule carcinomas and Leydig cell tumors. There was some evidence of the carcinogenic activity of 3-MCPD in female SD rats, based on the increased incidence of renal tubule adenomas. JF - Food and Chemical Toxicology AU - Cho, W S AU - Han, B S AU - Nam, K T AU - Park, K AU - Choi, M AU - Kim, SH AU - Jeong, J AU - Jang, D D AD - Korea Food and Drug Administration, National Institute of Toxicological Research, Seoul 122-704, Republic of Korea, ddjang@kfda.go.kr Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 3172 EP - 3177 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 9 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Body weight KW - renal tubules KW - Leydig cells KW - Carcinogenicity KW - Food KW - Tumors KW - Contaminants KW - Drinking water KW - Adenoma KW - Cancer KW - Carcinoma KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20940380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Carcinogenicity+study+of+3-monochloropropane-1%2C2-diol+in+Sprague-Dawley+rats&rft.au=Cho%2C+W+S%3BHan%2C+B+S%3BNam%2C+K+T%3BPark%2C+K%3BChoi%2C+M%3BKim%2C+SH%3BJeong%2C+J%3BJang%2C+D+D&rft.aulast=Cho&rft.aufirst=W&rft.date=2008-09-01&rft.volume=46&rft.issue=9&rft.spage=3172&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2008.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Body weight; Carcinogenicity; Leydig cells; renal tubules; Food; Tumors; Drinking water; Contaminants; Adenoma; Cancer; Carcinoma DO - http://dx.doi.org/10.1016/j.fct.2008.07.003 ER - TY - JOUR T1 - Diverse Myeloid and Lymphoid Cell Subpopulations Produce Gamma Interferon during Early Innate Immune Responses to Francisella tularensis Live Vaccine Strain AN - 20887977; 8406445 AB - Francisella tularensis, a small gram-negative intracellular bacterium responsible for causing tularemia, is highly pathogenic and classified as a category A agent of bioterrorism. As for other intracellular pathogens, successful protective immune responses to Francisella tularensis require rapid and efficient induction of gamma interferon (IFN-g) production. Studies using intracellular bacteria such as Listeria monocytogenes as well as Francisella suggest that natural killer (NK) and T cells are important sources of IFN-g. However, comprehensive characterization of specific sources of IFN-g produced during Francisella infection in vivo remains incomplete, and depletion of NK cells before infection of mice with the F. tularensis live vaccine strain (LVS) has little impact on the course or outcome of infection. In this study, we determined the cell subpopulations that respond quickly to intradermal F. tularensis LVS infection of mice by producing IFN-g within hours to a few days. Splenic and liver lymphocytes were obtained from LVS-infected mice and analyzed for IFN-g mRNA by reverse transcription-PCR, for intracellular cytokine expression by multiparameter flow cytometry, and for ex vivo production of IFN-g protein by enzyme-linked immunosorbent assay. Cells producing IFN-g were readily detectable by day 3 after infection, and numbers progressively increased through days 5 to 7. Importantly, the cell types responsible for IFN-g production were much more varied than expected: these included not only NK cells and T cells, which might be predicted, but also other cells, including dendritic cells (DCs), "NK DCs," NK T cells, and neutrophils. Most importantly, since RAG-1 knockout mice appeared to exhibit a frequency of IFN-g-producing cells comparable to that of intact wild-type mice, early IFN-g production by innate immune cells does not depend on the presence of T or B cells. JF - Infection and Immunity AU - De Pascalis, Roberto AU - Taylor, Betsy C AU - Elkins, Karen L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, U.S. FDA, 1401 Rockville Pike, HFM 431, Rockville, Maryland 20852. Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 4311 EP - 4321 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 9 SN - 0019-9567, 0019-9567 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Lymphoid cells KW - Listeria monocytogenes KW - Enzyme-linked immunosorbent assay KW - g-Interferon KW - Lymphocytes B KW - bioterrorism KW - Natural killer cells KW - Leukocytes (neutrophilic) KW - Spleen KW - Francisella tularensis KW - Pathogens KW - Infection KW - RAG1 protein KW - Flow cytometry KW - Dendritic cells KW - Tularemia KW - Lymphocytes T KW - Liver KW - Cytokines KW - Vaccines KW - J 02350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20887977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Diverse+Myeloid+and+Lymphoid+Cell+Subpopulations+Produce+Gamma+Interferon+during+Early+Innate+Immune+Responses+to+Francisella+tularensis+Live+Vaccine+Strain&rft.au=De+Pascalis%2C+Roberto%3BTaylor%2C+Betsy+C%3BElkins%2C+Karen+L&rft.aulast=De+Pascalis&rft.aufirst=Roberto&rft.date=2008-09-01&rft.volume=76&rft.issue=9&rft.spage=4311&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Lymphoid cells; Enzyme-linked immunosorbent assay; g-Interferon; bioterrorism; Lymphocytes B; Leukocytes (neutrophilic); Natural killer cells; Spleen; Pathogens; Infection; RAG1 protein; Flow cytometry; Dendritic cells; Tularemia; Liver; Lymphocytes T; Cytokines; Vaccines; Listeria monocytogenes; Francisella tularensis ER - TY - JOUR T1 - Racial/Ethnic, Socioeconomic, and Behavioral Determinants of Childhood and Adolescent Obesity in the United States: Analyzing Independent and Joint Associations AN - 20561667; 9272848 AB - Purpose This study examines independent and joint associations between several socioeconomic, demographic, and behavioral characteristics and obesity prevalence among 46,707 children aged 10-17 years in the United States. Methods The 2003 National Survey of Children's Health was used to calculate obesity prevalence. Logistic regression was used to estimate odds of obesity and adjusted prevalence. Results Ethnic minority status, non-metropolitan residence, lower socioeconomic status (SES) and social capital, higher television viewing, and higher physical inactivity levels were all independently associated with higher obesity prevalence. Adjusted obesity prevalence varied by age, gender, race/ethnicity, and SES. Compared with affluent white children, the odds of obesity were 2.7, 1.9 and 3.2 times higher for the poor Hispanic, white, and black children, respectively. Hispanic, white, and black children watching television 3 hours or more per day had 1.8, 1.9, and 2.5 times higher odds of obesity than white children who watched television less than 1 hour/day, respectively. Poor children with a sedentary lifestyle had 3.7 times higher odds of obesity than their active, affluent counterparts (adjusted prevalence, 19.8% vs. 6.7%). Conclusions Race/ethnicity, SES, and behavioral factors are independently related to childhood and adolescent obesity. Joint effects by gender, race/ethnicity, and SES indicate the potential for considerable reduction in the existing disparities in childhood obesity in the United States. JF - Annals of Epidemiology AU - Singh, Gopal K AU - Kogan, Michael D AU - Van Dyck, Peter C AU - Siahpush, Mohammad AD - From the Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, gsingh@hrsa.gov PY - 2008 SP - 682 EP - 695 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 18 IS - 9 SN - 1047-2797, 1047-2797 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Childhood and Adolescent Obesity KW - Ethnicity KW - Socioeconomic Status KW - Social Capital KW - Neighborhood Safety KW - Television Viewing KW - Physical Activity KW - United States KW - demography KW - Obesity KW - Age KW - Blacks KW - Adolescence KW - obesity KW - Socioeconomics KW - Children KW - affluence KW - Demographics KW - Joints KW - USA KW - Socioeconomic factors KW - Television KW - Gender KW - physical activity KW - Ethnic groups KW - Adolescents KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20561667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Racial%2FEthnic%2C+Socioeconomic%2C+and+Behavioral+Determinants+of+Childhood+and+Adolescent+Obesity+in+the+United+States%3A+Analyzing+Independent+and+Joint+Associations&rft.au=Singh%2C+Gopal+K%3BKogan%2C+Michael+D%3BVan+Dyck%2C+Peter+C%3BSiahpush%2C+Mohammad&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2008-09-01&rft.volume=18&rft.issue=9&rft.spage=682&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2008.05.001 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-12-16 N1 - SubjectsTermNotLitGenreText - Obesity; Socioeconomic factors; Blacks; Adolescence; Gender; Television; Children; Demographics; Joints; demography; Age; obesity; Socioeconomics; physical activity; affluence; Adolescents; Ethnic groups; USA DO - http://dx.doi.org/10.1016/j.annepidem.2008.05.001 ER - TY - JOUR T1 - Raw Single-Wall Carbon Nanotubes Induce Oxidative Stress and Activate MAPKs, AP-1, NF- Kappa B, and Akt in Normal and Malignant Human Mesothelial Cells AN - 20254038; 8543165 AB - BACKGROUND: Single-wall carbon nanotubes (SWCNTs), with their unique physicochemical and mechanical properties, have many potential new applications in medicine and industry. There has been great concern subsequent to preliminary investigations of the toxicity, biopersistence, patho-genicity, and ability of SWCNTs to translocate to subpleural areas. These results compel studies of potential interactions of SWCNTs with mesothelial cells. Objective: Exposure to asbestos is the primary cause of malignant mesothelioma in 80-90% of individuals who develop the disease. Because tie mesothelial cells are the primary target cells of asbestos-induced molecular changes mediated through an oxidant-linked mechanism, we used normal mesothelial and malignant mesothelial cells to investigate alterations in molecular signaling in response to a commercially manufactured SWCNT. METHODS: In the present study, we exposed mesothelial cells to SWCNTs and investigated reactive oxygen species (ROS) generation, cell viability, DNA damage, histone H2AX phosphorylation, activation of poly(ADP-ribose) polymerase 1 (PARP-1), stimulation of extracellular signal-regulated kinase (ERKs), Jun N-terminal kinases (JNKs), protein p38, and activation of activator protein-1 (AP-1), nuclear factor Kappa B (NF- Kappa B), and protein serine-threonine kinase (Akt). RESULTS: Exposure to SWCNTs induced ROS generation, increased cell death, enhanced DNA damage and H2AX phosphorylation, and activated PARP, AP-1, NF- Kappa B, p38, and Akt in a dose-dependent manner. These events recapitulate some of the key molecular events involved in mesothelioma development associated with asbestos exposure. Conclusions: The cellular and molecular findings reported here do suggest that SWCNTs can cause potentially adverse cellular responses in mesothelial cells through activation of molecular signaling associated with oxidative stress, which is of sufficient significance to warrant in vivo animal exposure studies. JF - Environmental Health Perspectives AU - Pacurari, M AU - Yin, X J AU - Zhao, J AU - Ding, M AU - Leonard, S S AU - Schwegler-Berry, D AU - Ducatman, B S AU - Sbarra, D AU - Hoover, MD AU - Castranova, V AU - Vallyathan, V AD - NIOSH/CDC, 1095 Willowdale Rd., Morgantown, WV 26505 USA, vav1@cdc.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1211 EP - 1217 VL - 116 IS - 9 SN - 0091-6765, 0091-6765 KW - Biochemistry Abstracts 2: Nucleic Acids; Environment Abstracts KW - AKT protein KW - Activator protein 1 KW - Toxicity KW - N 14820:DNA Metabolism & Structure KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20254038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Raw+Single-Wall+Carbon+Nanotubes+Induce+Oxidative+Stress+and+Activate+MAPKs%2C+AP-1%2C+NF-+Kappa+B%2C+and+Akt+in+Normal+and+Malignant+Human+Mesothelial+Cells&rft.au=Pacurari%2C+M%3BYin%2C+X+J%3BZhao%2C+J%3BDing%2C+M%3BLeonard%2C+S+S%3BSchwegler-Berry%2C+D%3BDucatman%2C+B+S%3BSbarra%2C+D%3BHoover%2C+MD%3BCastranova%2C+V%3BVallyathan%2C+V&rft.aulast=Pacurari&rft.aufirst=M&rft.date=2008-09-01&rft.volume=116&rft.issue=9&rft.spage=1211&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10924 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Activator protein 1; Toxicity DO - http://dx.doi.org/10.1289/ehp.10924 ER - TY - JOUR T1 - National trends in silicosis mortality in the United States, 1981-2004 AN - 20253975; 8891696 AB - Background This article describes trends in mortality with silicosis and identifies industries and occupations with elevated silicosis mortality. Methods A total of 6,326 deaths with silicosis for 1981-2004 were analyzed for trends and association with occupation and industry. Annual mortality rates were age-adjusted to the U.S. Year 2000 population. A linear regression model was used for analyzing mortality trends. Proportionate mortality ratios (PMRs) were based on 1,440 deaths with information on usual industry and occupation. Results Overall age-adjusted mortality rates per million declined from 2.4 in 1981 to 0.7 in 2004. Industries having significantly elevated PMRs for silicosis included mining and quarrying. Occupations with elevated PMRs included those associated with metal and mineral processing. Conclusions The results suggest that considerable progress has been made towards elimination of this preventable disease. However, about 30 silicosis deaths per year have been recorded since 1995 among those of working age, warranting continued efforts to effectively limit workplace exposures. Am. J. Ind. Med. 51:633-639, 2008. Published 2008 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Bang, Ki Moon AU - Attfield, Michael D AU - Wood, John M AU - Syamlal, Girija AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, kmb2@cdc.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 633 EP - 639 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 51 IS - 9 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Mortality KW - Metals KW - USA KW - Age KW - Quarrying KW - Silicosis KW - mineral processing KW - Mining KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20253975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=National+trends+in+silicosis+mortality+in+the+United+States%2C+1981-2004&rft.au=Bang%2C+Ki+Moon%3BAttfield%2C+Michael+D%3BWood%2C+John+M%3BSyamlal%2C+Girija&rft.aulast=Bang&rft.aufirst=Ki&rft.date=2008-09-01&rft.volume=51&rft.issue=9&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20607 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Metals; Mortality; Age; Quarrying; Silicosis; mineral processing; Mining; USA DO - http://dx.doi.org/10.1002/ajim.20607 ER - TY - JOUR T1 - A cohort mortality study of chemical laboratory workers at Department of Energy Nuclear Plants AN - 20251455; 8891699 AB - Objective This study evaluates the mortality experience of 6,157 chemical laboratory workers employed at United States Department of Energy facilities. Methods All cause, all cancer and cause-specific standardized mortality ratios were calculated. Cox regression analyses were conducted to further evaluate the relation between chemical exposure and mortality risk due to selected cancers. Results The mortality due to all causes combined and all cancers combined were below expectation for the cohort. There were no statistically significant elevations reported among males for any specific cancer or non-cancer outcome. There no statistically significant elevations among females for any specific non-cancer and most specific cancers; however, multiple myeloma deaths were significantly elevated (SMR=3.56; 95% CI=1.43-7.33; number of observed deaths, n=7). Statistically significant elevations were seen among workers employed 20+ years for leukemia using both 2- and 5-year lag periods. Also, a statistically significant positive trend of elevated lung cancer mortality with increasing employment duration was seen using both 5- and 10-year lags. A similar trend was seen for smoking related cancers among men. Conclusion While lymphatic and hematopoietic cancer mortality was below expectation, a significant elevation of multiple myeloma deaths among females and an elevation of leukemia among workers employed 20+ years (possibly due to radiation and benzene exposure) were observed. A NIOSH case-control study is underway to examine more closely the relation between multiple myeloma and a variety of chemical exposures among workers employed at the Oak Ridge K-25 facility. Am. J. Ind. Med. 51:656-667, 2008. Published 2008 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Kubale, Travis AU - Hiratzka, Shannon AU - Henn, Scott AU - Markey, Andrea AU - Daniels, Robert AU - Utterback, David AU - Waters, Kathy AU - Silver, Sharon AU - Robinson, Cynthia AU - Macievic, Gregory AU - Lodwick, Jeffrey AD - Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, tek2@cdc.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 656 EP - 667 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 51 IS - 9 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - employment KW - multiple myeloma KW - Cancer KW - Benzene KW - USA, Tennessee, Oak Ridge KW - Leukemia KW - Smoking KW - USA KW - Standards KW - Nuclear energy KW - Occupational exposure KW - Lung cancer KW - H 8000:Radiation Safety/Electrical Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20251455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=A+cohort+mortality+study+of+chemical+laboratory+workers+at+Department+of+Energy+Nuclear+Plants&rft.au=Kubale%2C+Travis%3BHiratzka%2C+Shannon%3BHenn%2C+Scott%3BMarkey%2C+Andrea%3BDaniels%2C+Robert%3BUtterback%2C+David%3BWaters%2C+Kathy%3BSilver%2C+Sharon%3BRobinson%2C+Cynthia%3BMacievic%2C+Gregory%3BLodwick%2C+Jeffrey&rft.aulast=Kubale&rft.aufirst=Travis&rft.date=2008-09-01&rft.volume=51&rft.issue=9&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20601 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoking; Leukemia; Mortality; employment; multiple myeloma; Nuclear energy; Standards; Benzene; Occupational exposure; Cancer; Lung cancer; USA, Tennessee, Oak Ridge; USA DO - http://dx.doi.org/10.1002/ajim.20601 ER - TY - JOUR T1 - An expanded model for predicting surface coal mine drill respirable dust emissions AN - 20236794; 8565823 AB - Overexposure to airborne respirable crystalline silica dust can cause disabling or fatal respiratory disease, and mine worker exposure to silica dust continues to be an ongoing occupational health concern. Exposures of surface coal mine rock drillers to respirable crystalline silica are of particular concern. On surface coal mine drills, bailing air flushes the cuttings out of the drill hole. Conveyor belting material is typically used to fabricate a shroud around the drill deck in an effort to contain the drill dust so that it can be captured by a collector. Dust leakage from the drill shroud is usually the worst dust source problem on most drills. The focus of this work is drill shroud dust leakage and the relationships of various drill parameters on this leakage. Experimental data were obtained and used in combination with dimensional analysis to establish these relationships. In general, it is found that airborne respirable dust (ARD) concentrations vary in a direct relationship with shroud leakage area and in an inverse relationship with drill deck cross-sectional area and shroud height. This work expands the testing and dimensional analysis previously reported for collector/bailing air flow ratios ranging from 2:1 to 4:1 to include ratios approaching 1:1. A semi-empirical mathematical model has been developed and expanded to describe ARD generation on surface coal mine drills. Geometric parameters included are drill deck height and cross-sectional area, shroud leakage associated with the deck shroud, and the operational parameters of bailing airflow and dust collector airflow. The relationships can be described by logarithmic functions and yield predictive ARD values, which fall in the range measured on operating drills for collector/bailing air flow ratios greater than 2. However, at values of collector/bailing air flow ratios of approximately 1.1, the amount of ARD shows minimal response, if any, to drill deck shroud improvements that do not result in near-perfect seals. This is a condition that can occur in actual operation and is a substantially different result than previously expected and reported. Application of these results should provide mine operators with sufficient information to determine (1) the relative magnitude of their dust emissions, (2) where they should focus their efforts to reduce ARD emissions and (3) the improvement they could reasonably expect to achieve. Given that exposures of surface coal mine rock drillers to respirable crystalline silica are of particular concern, substantial reductions of airborne silica dust during drilling may be estimated and achieved through use of the analysis presented. JF - International Journal of Mining, Reclamation and Environment AU - Page, S J AU - Reed, R AU - Listak, J M AD - Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA, USA, sep8@cdc.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 210 EP - 221 VL - 22 IS - 3 SN - 1748-0930, 1748-0930 KW - Pollution Abstracts KW - Coal KW - Respiratory diseases KW - Dust collectors KW - air flow KW - seals KW - silica KW - Emissions KW - Occupational exposure KW - Leakage KW - Mathematical models KW - Mines KW - Occupational health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20236794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Mining%2C+Reclamation+and+Environment&rft.atitle=An+expanded+model+for+predicting+surface+coal+mine+drill+respirable+dust+emissions&rft.au=Page%2C+S+J%3BReed%2C+R%3BListak%2C+J+M&rft.aulast=Page&rft.aufirst=S&rft.date=2008-09-01&rft.volume=22&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Mining%2C+Reclamation+and+Environment&rft.issn=17480930&rft_id=info:doi/10.1080%2F17480930701828833 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - seals; air flow; Mathematical models; Leakage; silica; Emissions; Respiratory diseases; Coal; Mines; Dust collectors; Occupational exposure; Occupational health DO - http://dx.doi.org/10.1080/17480930701828833 ER - TY - JOUR T1 - Acute Upper and Lower Respiratory Effects in Wildland Firefighters AN - 20205479; 8535677 AB - Objectives: To assess acute respiratory effects experienced by wildland firefighters. Methods: We studied two Interagency Hotshot Crews with questionnaires, spirometry, and measurement of albumin, eosinophilic cationic protein (ECP), and myeloperoxidase (MPO) as indicators of inflammation in sputum and nasal lavage fluid. Assessments were made preseason, postfire, and postseason. Results: Fifty-eight members of the two crews had at least two assessments. Mean upper and lower respiratory symptom scores were higher postfire compared to preseason (P < 0.001). The mean forced expiratory volume in 1 second was lower postfire compared to preseason (P < 0.001) and then recovered by postseason. Individual increases in sputum and nasal ECP and MPO from preseason to postfire were all significantly associated with postfire respiratory symptom scores. Conclusions: Wildland firefighting was associated with upper and lower respiratory symptoms and reduced forced expiratory volume in 1 second. Within individuals, symptoms were associated with increased ECP and MPO in sputum and nasal lavage fluid. The long-term respiratory health impact of wildland firefighting, especially over multiple fire seasons, remains an important concern. JF - Journal of Occupational and Environmental Medicine AU - Gaughan, D M AU - Cox-Ganser, J M AU - Enright, P L AU - Castellan, R M AU - Wagner, G R AU - Hobbs, G R AU - Bledsoe, T A AU - Siegel, P D AU - Kreiss, K AU - Weissman, D N AD - NIOSH MS-H2800,1095 Willowdale Road, Morgantown, WV 26505, USA, dug5@cdc.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1019 EP - 1028 VL - 50 IS - 9 SN - 1076-2752, 1076-2752 KW - Sustainability Science Abstracts; Health & Safety Science Abstracts KW - Fires KW - Occupational safety KW - Wildfire KW - Proteins KW - Respiratory function KW - Emergency medical services KW - M3 1010:Issues in Sustainable Development KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20205479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Acute+Upper+and+Lower+Respiratory+Effects+in+Wildland+Firefighters&rft.au=Gaughan%2C+D+M%3BCox-Ganser%2C+J+M%3BEnright%2C+P+L%3BCastellan%2C+R+M%3BWagner%2C+G+R%3BHobbs%2C+G+R%3BBledsoe%2C+T+A%3BSiegel%2C+P+D%3BKreiss%2C+K%3BWeissman%2C+D+N&rft.aulast=Gaughan&rft.aufirst=D&rft.date=2008-09-01&rft.volume=50&rft.issue=9&rft.spage=1019&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181754161 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Wildfire; Proteins; Fires; Emergency medical services; Occupational safety; Respiratory function DO - http://dx.doi.org/10.1097/JOM.0b013e3181754161 ER - TY - JOUR T1 - Frequency and spectrum of ENU-induced mutation in the X174 transgene in mouse splenic lymphocytes and their significance to spontaneous transgenic rodent mutation frequencies AN - 20061349; 8534229 AB - A perceived disadvantage of transgenic rodent mutation assays is that spontaneous mutant frequencies are high compared to those of endogenous genes and may consequently reduce sensitivity to induced mutation. We have previously argued that unrepaired G:T mismatches from spontaneous deamination of 5-methylcytosine at CpG sites could be converted to apparent in vivo mutations in the bacterial recovery systems because of rapid, random, mismatch repair in Escherichia coli. In this study, we have measured mutation frequencies in spleen of male mice induced by N-ethyl-N-nitrosourea (ENU) using the X174 transgene, which is not subject to mismatch repair in E.coli, using single-burst analysis, a unique method to identify in vivo mutation. In order to compare our results to those using the lacI and cII transgenes, we converted all mutant frequencies to base pair substitution (bps) mutation frequencies per nucleotide based on mutant spectra from this study and published literature. We found this frequency in control spleen to be similar for lacI (3.8 ± 0.7 x 108) and X174 (3.1 ± 1.2 x 108) at 6 weeks of age. We found a strong age dependence for spontaneous lacI mutation that extrapolated to a value at conception (1.8 ± 0.9 x 108) that was not significantly different from the human germ line bps mutation frequency per nucleotide of 1.7 ± 0.2 x 108. These two transgenes provided similar mutational responses to 40 mg/kg ENU, 7- to 9-fold. In contrast, the cII target gene in the same tissue produces both spontaneous and induced mutation frequencies 10 times higher, for unknown reasons. We conclude that the spontaneous mutant frequencies measured by the lacI and X174 transgenes in this moderately dividing tissue accurately measure in vivo mutation frequencies at early ages. For these two transgenes, seemingly high mutant frequencies may reflect the expected accumulation of somatic mutation with age. JF - Mutagenesis AU - Valentine, Carrie R AU - Rainey, Heather F AU - Farrell, Jessica M AU - Shaddock, Joseph G AU - Dobrovolsky, Vasily N AU - Delongchamp, Robert R AD - 1 Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT-120, Jefferson, AR 72079, USA, rdelongchamp@uams.edu Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 383 EP - 397 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 23 IS - 5 SN - 0267-8357, 0267-8357 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Age KW - mismatch repair KW - Deamination KW - Transgenes KW - Spleen KW - Mutant frequency KW - Lymphocytes KW - CpG islands KW - Transgenic mice KW - Nucleotides KW - Mutagenesis KW - Escherichia coli KW - Ethyl nitrosourea KW - Mutation KW - Base pairs KW - J 02410:Animal Diseases KW - W 30925:Genetic Engineering KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20061349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Frequency+and+spectrum+of+ENU-induced+mutation+in+the+X174+transgene+in+mouse+splenic+lymphocytes+and+their+significance+to+spontaneous+transgenic+rodent+mutation+frequencies&rft.au=Valentine%2C+Carrie+R%3BRainey%2C+Heather+F%3BFarrell%2C+Jessica+M%3BShaddock%2C+Joseph+G%3BDobrovolsky%2C+Vasily+N%3BDelongchamp%2C+Robert+R&rft.aulast=Valentine&rft.aufirst=Carrie&rft.date=2008-09-01&rft.volume=23&rft.issue=5&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=02678357&rft_id=info:doi/10.1093%2Fmutage%2Fgen026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; mismatch repair; Transgenes; Deamination; Spleen; Mutant frequency; CpG islands; Lymphocytes; Transgenic mice; Nucleotides; Mutagenesis; Ethyl nitrosourea; Mutation; Base pairs; Escherichia coli DO - http://dx.doi.org/10.1093/mutage/gen026 ER - TY - JOUR T1 - Anaplasma phagocytophilum-induced gene expression in both human neutrophils and HL-60 cells AN - 19717302; 8435688 AB - Anaplasma phagocytophilum (Ap), the etiologic agent of the tick-borne disease human granulocytic anaplasmosis, is an obligate intracellular pathogen unique in its ability to target and replicate within neutrophils. We define and compare the spectra of host gene expression in response to Ap infection of human neutrophils and of HL-60 cells using long (70-mer)-oligonucleotide array technology. In addition to apoptosis-related genes, genes involved in signaling pathways, transcriptional regulation, immune response, host defense, cell adhesion, and cytoskeleton were modulated in neutrophils infected with Ap. Ap infection affected the same pathways in HL-60 cells but transcriptional changes occurred more slowly and in a reduced spectrum of genes. Gene expression changes detected by microarray were confirmed for randomly selected genes by QRT-PCR and Western blot studies. These studies demonstrate for the first time that the ERK pathway is activated in Ap-infected neutrophils and also define multiple pathways that are activated during intracellular Ap infection, which together serve to prolong the cell survival that is needed to allow bacterial replication and survival in neutrophils, which otherwise would rapidly apoptose. JF - Genomics AU - Lee, H C AU - Kioi, M AU - Han, J AU - Puri, R K AU - Goodman, J L AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA, jesse.goodman@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 144 EP - 151 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 92 IS - 3 SN - 0888-7543, 0888-7543 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Cell survival KW - Western blotting KW - Replication KW - Anaplasma phagocytophilum KW - Leukocytes (neutrophilic) KW - Transcription KW - Pathogens KW - Infection KW - Anaplasma KW - DNA microarrays KW - Cell adhesion KW - Gene expression KW - Cytoskeleton KW - Extracellular signal-regulated kinase KW - Anaplasmosis KW - Gene regulation KW - tick-borne diseases KW - Immune response KW - Signal transduction KW - J 02350:Immunology KW - W 30900:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19717302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Anaplasma+phagocytophilum-induced+gene+expression+in+both+human+neutrophils+and+HL-60+cells&rft.au=Lee%2C+H+C%3BKioi%2C+M%3BHan%2C+J%3BPuri%2C+R+K%3BGoodman%2C+J+L&rft.aulast=Lee&rft.aufirst=H&rft.date=2008-09-01&rft.volume=92&rft.issue=3&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Genomics&rft.issn=08887543&rft_id=info:doi/10.1016%2Fj.ygeno.2008.05.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Western blotting; Replication; Leukocytes (neutrophilic); Transcription; Pathogens; Infection; DNA microarrays; Cell adhesion; Cytoskeleton; Gene expression; Extracellular signal-regulated kinase; Anaplasmosis; Gene regulation; tick-borne diseases; Immune response; Signal transduction; Anaplasma phagocytophilum; Anaplasma DO - http://dx.doi.org/10.1016/j.ygeno.2008.05.005 ER - TY - JOUR T1 - Universal virus detection by degenerate-oligonucleotide primed polymerase chain reaction of purified viral nucleic acids AN - 19712074; 8468774 AB - This study describes a novel non-specific universal virus detection method that permits molecular detection of viruses in biological materials containing mixtures of cells and viruses. Samples are subjected to nuclease digestion and ultracentrifugation to separate encapsidated viral nucleic acids from cellular nucleic acids. A degenerate oligonucleotide primer PCR (DOP-PCR) that has been optimized for the non-specific amplification of virus sized genomes is then employed. Virus identification is performed by sequencing of cloned DOP-PCR products followed by sequence comparison to sequences published in GenBank. This method was used to detect a variety of DNA viruses (including HSV, VZV, SV40, AAV, and EBV) and RNA viruses (including HTLV-I, HTLV-II, influenza, and poliovirus), which were spiked into cells, constitutively expressed in cell culture, or detected in productively infected cultured cells. This novel approach was compared with a non-specific virus detection method used previously and found to be several logs more sensitive. This type of approach has potential utility in solving virus detection and discovery problems where other methods have failed. JF - Journal of Virological Methods AU - Nanda, S AU - Jayan, G AU - Voulgaropoulou, F AU - Sierra-Honigmann, AM AU - Uhlenhaut, C AU - McWatters, BJP AU - Patel, A AU - Krause, PR AD - Food and Drug Administration, United States, philip.krause@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 18 EP - 24 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 152 IS - 1-2 SN - 0166-0934, 0166-0934 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Genomes KW - Poliovirus KW - Human T-lymphotropic virus 2 KW - Human T-lymphotropic virus 1 KW - Nuclease KW - RNA viruses KW - Cell culture KW - Oligonucleotides KW - Ultracentrifugation KW - DNA viruses KW - Adeno-associated virus KW - Influenza KW - Epstein-Barr virus KW - nucleic acids KW - Simian virus 40 KW - Varicella-zoster virus KW - Polymerase chain reaction KW - Primers KW - V 22300:Methods KW - N 14815:Nucleotide Sequence KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19712074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Universal+virus+detection+by+degenerate-oligonucleotide+primed+polymerase+chain+reaction+of+purified+viral+nucleic+acids&rft.au=Nanda%2C+S%3BJayan%2C+G%3BVoulgaropoulou%2C+F%3BSierra-Honigmann%2C+AM%3BUhlenhaut%2C+C%3BMcWatters%2C+BJP%3BPatel%2C+A%3BKrause%2C+PR&rft.aulast=Nanda&rft.aufirst=S&rft.date=2008-09-01&rft.volume=152&rft.issue=1-2&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2008.06.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Influenza; nucleic acids; Nuclease; Polymerase chain reaction; Cell culture; RNA viruses; Primers; DNA viruses; Ultracentrifugation; Oligonucleotides; Poliovirus; Epstein-Barr virus; Human T-lymphotropic virus 2; Human T-lymphotropic virus 1; Varicella-zoster virus; Simian virus 40; Adeno-associated virus DO - http://dx.doi.org/10.1016/j.jviromet.2008.06.007 ER - TY - JOUR T1 - Trans-natural antisense transcripts including noncoding RNAs in 10 species: implications for expression regulation AN - 19711613; 8523957 AB - Natural antisense transcripts are at least partially complementary to their sense transcripts. Cis-Sense/Antisense pairs (cis-SAs) have been extensively characterized and known to play diverse regulatory roles, whereas trans-Sense/Antisense pairs (trans-SAs) in animals are poorly studied. We identified long trans-SAs in human and nine other animals, using ESTs to increase coverage significantly over previous studies. The percentage of transcriptional units (TUs) involved in trans-SAs among all TUs was as high as 4.13%. Particularly 2896 human TUs (or 2.89% of all human TUs) were involved in 3327 trans-SAs. Sequence complementarities over multiple segments with predicted RNA hybridization indicated that some trans-SAs might have sophisticated RNA-RNA pairing patterns. One-fourth of human trans-SAs involved noncoding TUs, suggesting that many noncoding RNAs may function by a trans-acting antisense mechanism. TUs in trans-SAs were statistically significantly enriched in nucleic acid binding, ion/protein binding and transport and signal transduction functions and pathways; a significant number of human trans-SAs showed concordant or reciprocal expression pattern; a significant number of human trans-SAs were conserved in mouse. This evidence suggests important regulatory functions of trans-SAs. In 30 cases, trans-SAs were related to cis-SAs through paralogues, suggesting a possible mechanism for the origin of trans-SAs. All trans-SAs are available at http://trans.cbi.pku.edu.cn/ . JF - Nucleic Acids Research AU - Li, Jiong-Tang AU - Zhang, Yong AU - Kong, Lei AU - Liu, Qing-Rong AU - Wei, Liping AD - super(1)Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, 100871, P.R. China and super(2)Department of Health and Human Services (DHHS), Molecular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program (NIDA-IRP), NIH, Box 5180, Baltimore, MD 21224, USA Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 4833 EP - 4844 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - 15 SN - 0305-1048, 0305-1048 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Protein transport KW - Antisense KW - nucleic acids KW - RNA KW - Nucleotide sequence KW - Transcription KW - Proteins KW - expressed sequence tags KW - Complementarity KW - Signal transduction KW - W 30940:Products KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19711613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Trans-natural+antisense+transcripts+including+noncoding+RNAs+in+10+species%3A+implications+for+expression+regulation&rft.au=Li%2C+Jiong-Tang%3BZhang%2C+Yong%3BKong%2C+Lei%3BLiu%2C+Qing-Rong%3BWei%2C+Liping&rft.aulast=Li&rft.aufirst=Jiong-Tang&rft.date=2008-09-01&rft.volume=36&rft.issue=15&rft.spage=4833&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn470 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein transport; Antisense; nucleic acids; RNA; Nucleotide sequence; Proteins; Transcription; expressed sequence tags; Complementarity; Signal transduction DO - http://dx.doi.org/10.1093/nar/gkn470 ER - TY - JOUR T1 - Concentrations of Saxitoxin and Tetrodotoxin in Three Species of Puffers from the Indian River Lagoon, Florida, the Location for Multiple Cases of Saxitoxin Puffer Poisoning from 2002 to 2004 AN - 19653584; 8682860 AB - In response to multiple, unexpected cases of saxitoxin poisoning that started in January 2002, southern puffers Sphoeroides nephelus, checkered puffers S. testudineus, and bandtail puffers S. spengleri were collected from April to August 2002 from several locations in the Indian River Lagoon (IRL), Florida. Fish were analyzed for saxitoxin (STX) and tetrodotoxin (TTX) content in muscle, liver, and gonad tissues by means of the liquid chromatography-electrospray ionization-mass spectrometry method in multiple reactions monitoring mode. Spatial, species, and tissue-specific differences in toxin content and composition were found among these puffer species in the IRL. Southern puffers from the northern IRL had the highest concentrations of STX, muscle being the most contaminated tissue (1,770 +/- 159 kg/100 g tissue [mean +/- SD]; n = 3). Southern puffers from the Banana River and central IRL had lower amounts of STX in all tissues tested. Nearly all southern puffer tissues tested had only trace amounts of TTX. Both checkered and bandtail puffers from the central and southern IRL had higher concentrations of TTX than of STX in all tissues, checkered puffer livers being the most toxic (6,075 +/- 3,283 kg/100 g tissue; n = 3). For comparison, U.S. mid-Atlantic northern puffers S. maculatus (n = 10) were tested and found to contain no detectable amounts of STX or TTX. This research confirms that STX and not TTX was responsible for 28 poisoning cases in southern puffers from the northern IRL between 2002 and 2004, and it describes for the first time the relative distribution of STX and TTX in U.S. East Coast puffers. JF - Transactions of the American Fisheries Society AU - Deeds, Jonathan R AU - White, Kevin D AU - Etheridge, Stacey M AU - Landsberg, Jan H AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20723, USA Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1317 EP - 1326 PB - American Fisheries Society, 5410 Grosvenor Ln. Ste. 110 Bethesda MD 20814-2199 USA VL - 137 IS - 5 SN - 0002-8487, 0002-8487 KW - Pollution Abstracts; Aqualine Abstracts; Ecology Abstracts; Water Resources Abstracts; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Toxicants KW - Tetrodotoxin KW - Freshwater KW - Musa KW - Testing Procedures KW - Rivers KW - Poisoning KW - Muscles KW - Animal physiology KW - rivers KW - Toxins KW - Coastal zone KW - Fish physiology KW - Fish Populations KW - Coastal lagoons KW - Monitoring KW - ASW, USA, Florida, Indian River Lagoon KW - Pollution monitoring KW - Lagoons KW - gonads KW - Muscle KW - Saxitoxin KW - Coasts KW - Toxicity KW - Spectrometry KW - Liver KW - Sphoeroides nephelus KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - P 2000:FRESHWATER POLLUTION KW - D 04040:Ecosystem and Ecology Studies KW - Q5 08504:Effects on organisms KW - SW 3030:Effects of pollution KW - Q1 08344:Reproduction and development KW - AQ 00003:Monitoring and Analysis of Water and Wastes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19653584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+the+American+Fisheries+Society&rft.atitle=Concentrations+of+Saxitoxin+and+Tetrodotoxin+in+Three+Species+of+Puffers+from+the+Indian+River+Lagoon%2C+Florida%2C+the+Location+for+Multiple+Cases+of+Saxitoxin+Puffer+Poisoning+from+2002+to+2004&rft.au=Deeds%2C+Jonathan+R%3BWhite%2C+Kevin+D%3BEtheridge%2C+Stacey+M%3BLandsberg%2C+Jan+H&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2008-09-01&rft.volume=137&rft.issue=5&rft.spage=1317&rft.isbn=&rft.btitle=&rft.title=Transactions+of+the+American+Fisheries+Society&rft.issn=00028487&rft_id=info:doi/10.1577%2FT07-204.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Rivers; Pollution monitoring; Toxicants; Fish physiology; Animal physiology; Tetrodotoxin; Coastal lagoons; Toxicity; Lagoons; Liver; Muscles; Poisoning; Saxitoxin; Spectrometry; Coastal zone; gonads; rivers; Toxins; Testing Procedures; Muscle; Fish Populations; Monitoring; Coasts; Musa; Sphoeroides nephelus; ASW, USA, Florida, Indian River Lagoon; Freshwater DO - http://dx.doi.org/10.1577/T07-204.1 ER - TY - JOUR T1 - Antibacterial Compounds from Rose Bengal-Sensitized Photooxidation of beta -Caryophyllene AN - 19651768; 8531597 AB - The bactericidal activity of beta -caryophyllene photooxidized in acetonitrile was examined for 5 Gram-positive and 4 Gram-negative foodborne bacteria. The beta -caryophyllene (5 10 super(-3) M) was photooxidized in acetonitrile containing Rose Bengal (6.25 10 super(-4) M) for 24 h under fluorescent light. The antimicrobial activities of samples were determined by the agar-disc diffusion method. Active compounds from the photooxidized beta -caryophyllene were isolated by silica gel open-column chromatography in conjunction with recyclic high-performance liquid chromatography (HPLC), and were identified by infrared spectroscopy, mass spectrometry, and nuclear magnetic resonance spectroscopy. The antimicrobial activity of the photooxidized beta -caryophyllene was strongly enhanced against Streptococcus aureus and Vibrio parahaemolyticus, relative to that of beta -caryophyllene, but was weakly enhanced against other tested bacteria. The photooxidized beta -caryophyllene contained 3 active compounds specific for these 2 bacteria, and the compounds were identified as 5- alpha -hydroxycaryophylla-4(12),8(13)-diene, 5- alpha -hydroxycaryophylla-3(4),8(13)-diene, and 5- beta -hydroxycaryophylla-3(4),8(13)-diene. The efficacies of these compounds were similar, but the efficacy of 5- beta -hydroxycaryophylla-3(4),8(13)-diene was slightly higher than that of the other 2 compounds. The results suggest that the antibacterial activities of beta -caryophyllene for S. aureus and V. parahaemolyticus could be enhanced by dye-sensitized photooxidation, and the photooxidized beta -caryophyllene and the isolated individual compounds could be useful antimicrobial agents to control the growth of S. aureus and V. parahaemolyticus in certain food systems. JF - Journal of Food Science AU - Kim, Y S AU - Park, S J AU - Lee, E J AU - Cerbo, R M AU - Lee, S M AU - Ryu, CH AU - Kim, G S AU - Kim, JO AU - Ha, Y L AD - Authors Y.S. Kim, R.M. Cerbo, S.M. Lee, C.H. Ryu, and Y.L. Ha are with Division of Applied Life Sciences (BK21 Program), Graduate School, and Inst. of Agriculture & Life Science and author G.S. Kim is with School of Veterinary Medicine, Gyeongsang Natl. Univ., Jinju 660-701, Republic of Korea. Author S.J. Park is with College of Oriental Medicine, Daegu Haany Univ., Gyeongsan 712-715, Republic of Korea. Author E.J. Lee is with Korea Food and Drug Administration, Seoul 122-704, Republic of Korea. Author J.O. Kim is with HK Biotech Co. Ltd., Jinju 660-972, Republic of Korea. Direct inquiries to author Ha (E-mail: Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - C540 EP - C545 PB - Institute of Food Technology VL - 73 IS - 7 SN - 0022-1147, 0022-1147 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - antimicrobial activity KW - -caryophyllene KW - photooxidation KW - S. aureus KW - V. parahaemolyticus KW - High-performance liquid chromatography KW - Antimicrobial activity KW - Antibacterial activity KW - silica gel KW - Food KW - Mass spectrometry KW - Spectroscopy KW - Mass spectroscopy KW - I.R. spectroscopy KW - Vibrio parahaemolyticus KW - Diffusion KW - N.M.R. KW - NMR KW - Staphylococcus aureus KW - Bactericidal activity KW - Caryophyllene KW - Streptococcus KW - Chromatography KW - Light effects KW - Antimicrobial agents KW - Liquid chromatography KW - Photooxidation KW - Acetonitrile KW - antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials KW - H 4000:Food and Drugs KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19651768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Antibacterial+Compounds+from+Rose+Bengal-Sensitized+Photooxidation+of+beta+-Caryophyllene&rft.au=Kim%2C+Y+S%3BPark%2C+S+J%3BLee%2C+E+J%3BCerbo%2C+R+M%3BLee%2C+S+M%3BRyu%2C+CH%3BKim%2C+G+S%3BKim%2C+JO%3BHa%2C+Y+L&rft.aulast=Kim&rft.aufirst=Y&rft.date=2008-09-01&rft.volume=73&rft.issue=7&rft.spage=C540&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2Fj.1750-3841.2008.00879.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Antimicrobial activity; Antibacterial activity; Food; silica gel; Spectroscopy; Mass spectroscopy; Antimicrobial agents; Light effects; I.R. spectroscopy; Photooxidation; N.M.R.; Diffusion; Acetonitrile; Caryophyllene; Bactericidal activity; Chromatography; Liquid chromatography; Mass spectrometry; NMR; antimicrobial agents; Streptococcus; Vibrio parahaemolyticus; Staphylococcus aureus DO - http://dx.doi.org/10.1111/j.1750-3841.2008.00879.x ER - TY - JOUR T1 - Filtration Performance of NIOSH-Approved N95 and P100 Filtering Facepiece Respirators Against 4 to 30 Nanometer-Size Nanoparticles AN - 19602206; 8502095 AB - This study investigated the filtration performance of NIOSH-approved N95 and P100 filtering facepiece respirators (FFR) against six different monodisperse silver aerosol particles in the range of 4-30 nm diameter. A particle test system was developed and standardized for measuring the penetration of monodisperse silver particles. For respirator testing, five models of N95 and two models of P100 filtering facepiece respirators were challenged with monodisperse silver aerosol particles of 4, 8, 12, 16, 20, and 30 nm at 85 L/min flow rate and percentage penetrations were measured. Consistent with single-fiber filtration theory, N95 and P100 respirators challenged with silver monodisperse particles showed a decrease in percentage penetration with a decrease in particle diameter down to 4 nm. Penetrations less than 1 particle/30 min for 4-8 nm particles for one P100 respirator model, and 4-12 nm particles for the other P100 model, were observed. Experiments were also carried out with larger than 20 nm monodisperse NaCl particles using a TSI 3160 Fractional Efficiency Tester. NaCl aerosol penetration levels of 20 nm and 30 nm (overlapping sizes) particles were compared with silver aerosols of the same sizes by a three-way ANOVA analysis. A significant (p < 0.001) difference between NaCl and silver aerosol penetration levels was obtained after adjusting for particle sizes and manufacturers. A significant (p = 0.001) interaction with manufacturers indicated the difference in NaCl, and silver aerosol penetrations were not the same across manufacturers. The two aerosols had the same effect across 20 nm and 30 nm sizes as shown by the absence of any significant (p = 0.163) interaction with particle sizes. In the case of P100 FFRs, a significant (p < 0.001) difference between NaCl and silver aerosol (20 nm and 30 nm) penetrations was observed for both respirator models tested. The filtration data for 4-30 nm monodisperse particles supports previous studies that indicate NIOSH-approved air-purifying respirators provide expected levels of filtration protection against nanoparticles. JF - Journal of Occupational and Environmental Hygiene AU - Rengasamy, Samy AU - King, William P AU - Eimer, Benjamin C AU - Shaffer, Ronald E AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 556 EP - 564 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 9 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Aerosols KW - Filtration KW - Standards KW - Particulates KW - Respirators KW - Silver KW - Protective equipment KW - Occupational exposure KW - Flow rates KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Filtration+Performance+of+NIOSH-Approved+N95+and+P100+Filtering+Facepiece+Respirators+Against+4+to+30+Nanometer-Size+Nanoparticles&rft.au=Rengasamy%2C+Samy%3BKing%2C+William+P%3BEimer%2C+Benjamin+C%3BShaffer%2C+Ronald+E&rft.aulast=Rengasamy&rft.aufirst=Samy&rft.date=2008-09-01&rft.volume=5&rft.issue=9&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802275387 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Filtration; Aerosols; Standards; Particulates; Respirators; Protective equipment; Silver; Flow rates; Occupational exposure DO - http://dx.doi.org/10.1080/15459620802275387 ER - TY - JOUR T1 - Nicotine Leads to Improvements in Behavioral Impairment and an Increase in the Nicotine Acetylcholine Receptor in Transgenic Mice AN - 19532921; 8409744 AB - Nicotine is the principal psychoactive ingredient in cigarette smoke, and has been associated with health problems in humans. However, the pure form of nicotine may prove to be a valuable pharmaceutical agent for the treatment of AD. However, the beneficial effects of nicotine remain a matter of much controversy. In order to clarify this issue, 12-month-old transgenic mice, expressing neuron-specific enolase (NSE)-controlled APPsw, were treated with low, middle, and high doses of nicotine for 6 months. Herein, we have concluded that the nicotine-treated groups evidenced improvements in behavior and increases in the nicotine acetylcholine receptor, nAchR alpha 7. These findings provide experimental evidence that nicotine effects an improvement in impaired memory, and that this improvement is associated with an increase in nAchR alpha 7. Thus, nicotine may prove a good preventative or therapeutic modality for AD patients. JF - Neurochemical Research AU - Shim, Sun B AU - Lee, Se H AU - Chae, Kab R AU - Kim, Chuel K AU - Hwang, Dae Y AU - Kim, Byoung G AU - Jee, Seung W AU - Lee, Su H AU - Sin, Ji S AU - Bae, Chang J AU - Lee, Byoung C AU - Lee, Hyung H AU - Kim, Yong K AD - Korea Food and Drug Administration, 194 Tongilro Eunpyung-ku, Seoul, 122-704, Republic of Korea, kimyongkyu@hanmail.net Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1783 EP - 1788 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 33 IS - 9 SN - 0364-3190, 0364-3190 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Memory KW - Nicotine KW - Pharmaceuticals KW - Cigarette smoke KW - Transgenic mice KW - Acetylcholine receptors KW - Phosphopyruvate hydratase KW - Acetylcholine receptors (nicotinic) KW - W 30925:Genetic Engineering KW - N3 11008:Neurochemistry KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19532921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+Research&rft.atitle=Nicotine+Leads+to+Improvements+in+Behavioral+Impairment+and+an+Increase+in+the+Nicotine+Acetylcholine+Receptor+in+Transgenic+Mice&rft.au=Shim%2C+Sun+B%3BLee%2C+Se+H%3BChae%2C+Kab+R%3BKim%2C+Chuel+K%3BHwang%2C+Dae+Y%3BKim%2C+Byoung+G%3BJee%2C+Seung+W%3BLee%2C+Su+H%3BSin%2C+Ji+S%3BBae%2C+Chang+J%3BLee%2C+Byoung+C%3BLee%2C+Hyung+H%3BKim%2C+Yong+K&rft.aulast=Shim&rft.aufirst=Sun&rft.date=2008-09-01&rft.volume=33&rft.issue=9&rft.spage=1783&rft.isbn=&rft.btitle=&rft.title=Neurochemical+Research&rft.issn=03643190&rft_id=info:doi/10.1007%2Fs11064-008-9629-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Memory; Nicotine; Pharmaceuticals; Cigarette smoke; Phosphopyruvate hydratase; Acetylcholine receptors; Transgenic mice; Acetylcholine receptors (nicotinic) DO - http://dx.doi.org/10.1007/s11064-008-9629-5 ER - TY - JOUR T1 - alpha -Terpineol reactions with the nitrate radical: Rate constant and gas-phase products AN - 19489007; 8515569 AB - The bimolecular rate constant of k sub(N) sub(O) sub(3) sub(?) sub(+) sub( alpha ) sub(-) sub(t) sub(e) sub(r) sub(p) sub(i) sub(n) sub(e) sub(o) sub(l) (16+ /-4)x10 super(-) super(1) super(2)cm super(3)molecule super(-) super(1)s super(-) super(1) was measured using the relative rate technique for the reaction of the nitrate radical (NO sub(3)?) with alpha -terpineol (2-(4-methyl-1-cyclohex-3-enyl)propan-2-ol) at 297+/-3K and 1atmosphere total pressure. To more clearly define part of alpha -terpineol's indoor environment degradation mechanism, the products of alpha -terpineol+NO sub(3)? reaction were investigated. The identified reaction products were: acetone, glyoxal (HC(?O)C(?O)H), and methylglyoxal (CH sub(3)C(?O)C(?O)H). The use of derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) were used to propose the other major reaction products: 6-hydroxyhept-5-en-2-one, 4-(1-hydroxy-1-methylethyl)-1-methyl-2-oxocyclohexyl nitrate, 5-(1-hydroxy-1-methylethyl)-2-oxocyclohexyl nitrate, 1-formyl-5-hydroxy-4-(hydroxymethyl)-1,5-dimethylhexyl nitrate, and 1,4-diformyl-5-hydroxy-1,5-dimethylhexyl nitrate. The elucidation of these products was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible alpha -terpineol+NO sub(3)? reaction mechanisms based on previously published volatile organic compound+NO sub(3)? gas-phase mechanisms. The additional gas-phase products (2,6,6-trimethyltetrahydro-2H-pyran-2,5-dicarbaldehyde and 2,2-dimethylcyclohexane-1,4-dicarbaldehyde) are proposed to be the result of cyclization through a reaction intermediate. JF - Atmospheric Environment AU - Jones, B T AU - Ham, JE AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, bvo2@cdc.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 6689 EP - 6698 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 42 IS - 27 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - acetone KW - Nitrates KW - Mass spectrometry KW - Indoor environments KW - P 0000:AIR POLLUTION KW - M2 551.508:Instruments (551.508) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19489007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=alpha+-Terpineol+reactions+with+the+nitrate+radical%3A+Rate+constant+and+gas-phase+products&rft.au=Jones%2C+B+T%3BHam%2C+JE&rft.aulast=Jones&rft.aufirst=B&rft.date=2008-09-01&rft.volume=42&rft.issue=27&rft.spage=6689&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2008.04.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mass spectrometry; acetone; Nitrates; Indoor environments DO - http://dx.doi.org/10.1016/j.atmosenv.2008.04.017 ER - TY - JOUR T1 - Windows super(()R) based general PBPK/PD modeling software AN - 19342938; 8712385 AB - A physiologically based pharmacokinetic (PBPK) model and program (called PostNatal) was developed which focuses on postnatal growth. Algorithms defining organ/tissue growth curves from birth through adulthood for male and female humans, dogs, rats, and mice are utilized to calculate the appropriate weight and blood flow for the internal organs/tissues. This Windows super(()R) based program is actually four linked PBPK models with each PBPK model acting independently or totally integrated with the others through metabolism by first order or Michaelis-Menten kinetics. Data fitting is accomplished by a weighted least square regression algorithm. The model includes linkages for the simulation of pharmacodynamic (PD) effects. JF - Computers in Biology and Medicine AU - Luecke, R H AU - Pearce, BA AU - Wosilait, W D AU - Doerge AU - Slikker, W AU - Young, J F AD - National Center for Toxicological Research/FDA/DHHS, Jefferson, AR 72079, USA, john.young@fda.hhs.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 962 EP - 978 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 38 IS - 9 SN - 0010-4825, 0010-4825 KW - Biotechnology and Bioengineering Abstracts KW - Birth KW - Computer programs KW - software KW - Growth curves KW - Data processing KW - Kinetics KW - Algorithms KW - Computer applications KW - Pharmacodynamics KW - Pharmacokinetics KW - Metabolism KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19342938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+in+Biology+and+Medicine&rft.atitle=Windows+super%28%28%29R%29+based+general+PBPK%2FPD+modeling+software&rft.au=Luecke%2C+R+H%3BPearce%2C+BA%3BWosilait%2C+W+D%3BDoerge%3BSlikker%2C+W%3BYoung%2C+J+F&rft.aulast=Luecke&rft.aufirst=R&rft.date=2008-09-01&rft.volume=38&rft.issue=9&rft.spage=962&rft.isbn=&rft.btitle=&rft.title=Computers+in+Biology+and+Medicine&rft.issn=00104825&rft_id=info:doi/10.1016%2Fj.compbiomed.2008.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Algorithms; Data processing; Computer programs; Metabolism; Kinetics; Pharmacokinetics; software; Computer applications; Birth; Pharmacodynamics; Growth curves DO - http://dx.doi.org/10.1016/j.compbiomed.2008.06.001 ER - TY - JOUR T1 - Lead in women's and children's vitamins. AN - 69449802; 18646762 AB - A survey was conducted to determine the extent of lead (Pb) contamination in vitamins labeled for use by women and children. The Pb content of 324 multivitamin-mineral products was determined using microwave assisted nitric acid digestion and inductively coupled plasma mass spectrometry. Cryogenic grinding was used to composite soft samples such as oil filled capsules and candy-like products such as gummies and jelly beans. Estimates of Pb exposures from consumption of these products were derived for four population groups: young children (0-6 yrs), older children (7+ yrs), pregnant or lactating women, and adult women. The estimated median and maximum Pb exposures were 0.123 and 2.88 microg/day for young children, 0.356 and 1.78 microg/day for older children, 0.845 and 8.97 microg/day for pregnant and lactating women, and 0.842 and 4.92 microg/day for adult women. The overall median value for Pb exposure was 0.576 microg/day. Five samples would have provided exposures that exceeded 4 microg/day. Estimates of exposures were assessed with respect to safe/tolerable exposure levels that have been developed for the specific age and sex groups. These safe/tolerable levels are referred to as the provisional total tolerable intake levels (PTTI) and are 6, 15, 25, and 75 microg Pb/day for young children, older children, pregnant or lactating women, and adult women, respectively. Estimates of Pb exposures were below the PTTI levels for the four population groups. Median and maximum values were used instead of the mean and standard deviation because of the skewed distribution of results toward lower mass fraction and exposure. JF - Journal of agricultural and food chemistry AU - Mindak, William R AU - Cheng, John AU - Canas, Benjamin J AU - Bolger, P Michael AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration 5100 Paint Branch Parkway, Mail Stop HFS-716, College Park, Maryland 20740, USA. william.mindak@fda.hhs.gov Y1 - 2008/08/27/ PY - 2008 DA - 2008 Aug 27 SP - 6892 EP - 6896 VL - 56 IS - 16 KW - Vitamins KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Infant KW - Mass Spectrometry KW - Maximum Allowable Concentration KW - Humans KW - Adult KW - Infant, Newborn KW - Child KW - Female KW - Pregnancy KW - Lactation KW - Child, Preschool KW - Vitamins -- analysis KW - Drug Contamination KW - Lead -- analysis KW - Dietary Supplements -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69449802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Lead+in+women%27s+and+children%27s+vitamins.&rft.au=Mindak%2C+William+R%3BCheng%2C+John%3BCanas%2C+Benjamin+J%3BBolger%2C+P+Michael&rft.aulast=Mindak&rft.aufirst=William&rft.date=2008-08-27&rft.volume=56&rft.issue=16&rft.spage=6892&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Fjf801236w LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-06 N1 - Date created - 2008-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf801236w ER - TY - JOUR T1 - Irradiation in the production, processing and handling of food. Final rule. AN - 69720793; 18958941 AB - The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of ionizing radiation for control of food-borne pathogens, and extension of shelf-life, in fresh iceberg lettuce and fresh spinach (hereinafter referred to in this document as "iceberg lettuce and spinach") at a dose up to 4.0 kilo Gray (kGy). This action is in partial response to a petition filed by The National Food Processors Association on behalf of The Food Irradiation Coalition. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2008/08/22/ PY - 2008 DA - 2008 Aug 22 SP - 49593 EP - 49603 VL - 73 IS - 164 SN - 0097-6326, 0097-6326 KW - Food Additives KW - 0 KW - Health technology assessment KW - United States KW - United States Food and Drug Administration KW - Humans KW - Consumer Product Safety -- legislation & jurisprudence KW - Lettuce KW - Food Preservation -- legislation & jurisprudence KW - Food Contamination -- prevention & control KW - Food Irradiation -- legislation & jurisprudence KW - Food Handling -- legislation & jurisprudence KW - Food Handling -- methods KW - Food Contamination -- legislation & jurisprudence KW - Spinacia oleracea KW - Food Preservation -- methods KW - Time Factors KW - Food Irradiation -- methods KW - Legislation, Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69720793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Irradiation+in+the+production%2C+processing+and+handling+of+food.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2008-08-22&rft.volume=73&rft.issue=164&rft.spage=49593&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-31 N1 - Date created - 2008-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. AN - 69418596; 18472313 AB - Urinary metabolic perturbations associated with acute and chronic acetaminophen-induced hepatotoxicity were investigated using nuclear magnetic resonance (NMR) spectroscopy and ultra performance liquid chromatography/mass spectrometry (UPLC/MS) metabonomics approaches to determine biomarkers of hepatotoxicity. Acute and chronic doses of acetaminophen (APAP) were administered to male Sprague-Dawley rats. NMR and UPLC/MS were able to detect both drug metabolites and endogenous metabolites simultaneously. The principal component analysis (PCA) of NMR or UPLC/MS spectra showed that metabolic changes observed in both acute and chronic dosing of acetaminophen were similar. Histopathology and clinical chemistry studies were performed and correlated well with the PCA analysis and magnitude of metabolite changes. Depletion of antioxidants (e.g. ferulic acid), trigonelline, S-adenosyl-L-methionine, and energy-related metabolites indicated that oxidative stress was caused by acute and chronic acetaminophen administration. Similar patterns of metabolic changes in response to acute or chronic dosing suggest similar detoxification and recovery mechanisms following APAP administration. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Sun, Jinchun AU - Schnackenberg, Laura K AU - Holland, Ricky D AU - Schmitt, Thomas C AU - Cantor, Glenn H AU - Dragan, Yvonne P AU - Beger, Richard D AD - Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 328 EP - 340 VL - 871 IS - 2 SN - 1570-0232, 1570-0232 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Rats KW - Animals KW - Liver -- pathology KW - Necrosis -- urine KW - Necrosis -- pathology KW - Male KW - Nuclear Magnetic Resonance, Biomolecular -- methods KW - Rats, Sprague-Dawley -- urine KW - Chemical and Drug Induced Liver Injury KW - Acetaminophen -- poisoning KW - Liver Diseases -- pathology KW - Computational Biology -- methods KW - Chromatography, High Pressure Liquid -- methods KW - Mass Spectrometry -- methods KW - Liver Diseases -- urine KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69418596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Metabonomics+evaluation+of+urine+from+rats+given+acute+and+chronic+doses+of+acetaminophen+using+NMR+and+UPLC%2FMS.&rft.au=Sun%2C+Jinchun%3BSchnackenberg%2C+Laura+K%3BHolland%2C+Ricky+D%3BSchmitt%2C+Thomas+C%3BCantor%2C+Glenn+H%3BDragan%2C+Yvonne+P%3BBeger%2C+Richard+D&rft.aulast=Sun&rft.aufirst=Jinchun&rft.date=2008-08-15&rft.volume=871&rft.issue=2&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=15700232&rft_id=info:doi/10.1016%2Fj.jchromb.2008.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-09 N1 - Date created - 2008-08-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 1;877(1-2):105 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jchromb.2008.04.008 ER - TY - JOUR T1 - In vitro and in vivo percutaneous absorption of retinol from cosmetic formulations: Significance of the skin reservoir and prediction of systemic absorption AN - 20885950; 8414501 AB - The percutaneous absorption of retinol (Vitamin A) from cosmetic formulations was studied to predict systemic absorption and to understand the significance of the skin reservoir in in vitro absorption studies. Viable skin from fuzzy rat or human subjects was assembled in flow-through diffusion cells for in vitro absorption studies. In vivo absorption studies using fuzzy rats were performed in glass metabolism cages for collection of urine, feces, and body content. Retinol (0.3%) formulations (hydroalcoholic gel and oil-in-water emulsion) containing super(3)H-retinol were applied and absorption was measured at 24 or 72 h. All percentages reported are % of applied dose. In vitro studies using human skin and the gel and emulsion vehicles found 0.3 and 1.3% retinol, respectively, in receptor fluid at 24 h. Levels of absorption in the receptor fluid increased over 72 h with the gel and emulsion vehicles. Using the gel vehicle, in vitro rat skin studies found 23% in skin and 6% in receptor fluid at 24 h, while 72-h studies found 18% in skin and 13% in receptor fluid. Thus, significant amounts of retinol remained in rat skin at 24 h and decreased over 72 h, with proportional increases in receptor fluid. In vivo rat studies with the gel found 4% systemic absorption of retinol after 24 h and systemic absorption did not increase at 72 h. Retinol remaining in rat skin after in vivo application was 18% and 13% of the applied dermal dose after 24 and 72 h, respectively. Similar observations were made with the oil-in water emulsion vehicle in the rat. Retinol formed a reservoir in rat skin both in vivo and in vitro. Little additional retinol was bioavailable after 24 h. Comparison of these in vitro and in vivo results for absorption through rat skin indicates that the 24-h in vitro receptor fluid value accurately estimated 24-h in vivo systemic absorption. Therefore, the best single estimate of retinol systemic absorption from in vitro human skin studies is the 24-h receptor fluid value. However, the receptor fluid value from the 72-h extended study may be used in a worst-case exposure estimate. In conclusion, in vivo skin absorption studies can be useful in determining whether to include material in the in vitro skin reservoir as absorbable material in estimates of systemic absorption. JF - Toxicology and Applied Pharmacology AU - Yourick, J J AU - Jung, C T AU - Bronaugh, R L AD - Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA, jeffrey.yourick@fda.hhs.gov Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 117 EP - 121 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 231 IS - 1 SN - 0041-008X, 0041-008X KW - Toxicology Abstracts KW - Skin KW - Urine KW - Vitamin A KW - Cosmetics KW - Diffusion KW - Feces KW - Metabolism KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20885950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=In+vitro+and+in+vivo+percutaneous+absorption+of+retinol+from+cosmetic+formulations%3A+Significance+of+the+skin+reservoir+and+prediction+of+systemic+absorption&rft.au=Yourick%2C+J+J%3BJung%2C+C+T%3BBronaugh%2C+R+L&rft.aulast=Yourick&rft.aufirst=J&rft.date=2008-08-15&rft.volume=231&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2008.04.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Skin; Urine; Vitamin A; Diffusion; Cosmetics; Feces; Metabolism DO - http://dx.doi.org/10.1016/j.taap.2008.04.006 ER - TY - JOUR T1 - Designing toxicogenomics studies that use DNA array technology. AN - 734076181; 19812785 AB - Bioassays are routinely used to evaluate the toxicity of test agents. Experimental designs for bioassays are largely encompassed by fixed effects linear models. In toxicogenomics studies where DNA arrays measure mRNA levels, the tissue samples are typically generated in a bioassay. These measurements introduce additional sources of variation, which must be properly managed to obtain valid tests of treatment effects. An analysis of covariance model is developed which combines a fixed-effects linear model for the bioassay with important variance components associated with DNA array measurements. These models can accommodate the dominant characteristics of measurements from DNA arrays, and they account for technical variation associated with normalization, spots, dyes, and batches as well as the biological variation associated with the bioassay. An example illustrates how the model is used to identify valid designs and to compare competing designs. Many toxicogenomics studies are bioassays which measure gene expression using DNA arrays. These studies can be designed and analyzed using standard methods with a few modifications to account for characteristics of array measurements, such as multiple endpoints and normalization. As much as possible, technical variation associated with probes, dyes, and batches are managed by blocking treatments within these sources of variation. An example shows how some practical constraints can be accommodated by this modelling and how it allows one to objectively compare competing designs. JF - Bioinformatics and biology insights AU - Delongchamp, Robert R AU - Velasco, Cruz AU - Desai, Varsha G AU - Lee, Taewon AU - Fuscoe, James C AD - Biometry Branch, Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. rdelongchamp@uams.edu Y1 - 2008/08/14/ PY - 2008 DA - 2008 Aug 14 SP - 317 EP - 328 VL - 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734076181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics+and+biology+insights&rft.atitle=Designing+toxicogenomics+studies+that+use+DNA+array+technology.&rft.au=Delongchamp%2C+Robert+R%3BVelasco%2C+Cruz%3BDesai%2C+Varsha+G%3BLee%2C+Taewon%3BFuscoe%2C+James+C&rft.aulast=Delongchamp&rft.aufirst=Robert&rft.date=2008-08-14&rft.volume=2&rft.issue=&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Bioinformatics+and+biology+insights&rft.issn=1177-9322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-11 N1 - Date created - 2009-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Pathol. 2003 Sep-Oct;31(5):471-9 [14692614] Bioinformatics. 2003 Dec 12;19(18):2448-55 [14668230] Mutat Res. 2003 Nov;544(2-3):415-24 [14644344] Ann N Y Acad Sci. 2003 May;993:363-76; discussion 387-93 [12853330] Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7575-80 [12808153] Bioinformatics. 2003 May 1;19(7):803-10 [12724289] Pharm Res. 2002 Dec;19(12):1773-8 [12523654] Nat Rev Genet. 2002 Aug;3(8):579-88 [12154381] Curr Opin Mol Ther. 2002 Jun;4(3):229-35 [12139308] Curr Issues Mol Biol. 2002 Apr;4(2):45-56 [11931569] Biometrics. 2004 Sep;60(3):774-82 [15339301] Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:72-83 [15209406] Bioinformatics. 2004 Jun 12;20(9):1436-46 [14962916] BMC Bioinformatics. 2006;7 Suppl 2:S11 [17118132] Nucleic Acids Res. 2007;35(3):e18 [17169993] Neuroscience. 2007 Jan 5;144(1):66-76 [17049170] Bioinformatics. 2005 Jul 15;21(14):3065 [15941744] Nucleic Acids Res. 2006;34(9):e70 [16723429] Basic Clin Pharmacol Toxicol. 2006 Jun;98(6):537-46 [16700814] Nat Rev Genet. 2006 Jan;7(1):55-65 [16369572] BMC Bioinformatics. 2005;6 Suppl 2:S13 [16026598] Bioinformatics. 2005 Jun 15;21(12):2803-4 [15817695] Mutat Res. 2005 Aug 4;575(1-2):102-15 [15924886] Bioinformatics. 2005 May 1;21(9):1995-2000 [15691855] Bioinformatics. 2005 Apr 15;21(8):1502-8 [15564298] Bioinformatics. 2005 Feb 15;21(4):492-501 [15374872] Mol Carcinog. 1999 Mar;24(3):153-9 [10204799] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity. AN - 69398135; 18624435 AB - The discovery of acrylamide (AA) in many common cooked starchy foods has presented significant challenges to toxicologists, food scientists, and national regulatory and public health organizations because of the potential for producing neurotoxicity and cancer. This paper reviews some of the underlying experimental bases for AA toxicity and earlier risk assessments. Then, dietary exposure modeling is used to estimate probable AA intake in the U.S. population, and physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling is used to integrate the findings of rodent neurotoxicity and cancer into estimates of risks from human AA exposure through the diet. The goal of these modeling techniques is to reduce the uncertainty inherent in extrapolating toxicological findings across species and dose by comparing common exposure biomarkers. PBPK/PD modeling estimated population-based lifetime excess cancer risks from average AA consumption in the diet in the range of 1-4 x 10 (-4); however, modeling did not support a link between dietary AA exposure and human neurotoxicity because marginal exposure ratios were 50-300 lower than in rodents. In addition, dietary exposure modeling suggests that because AA is found in so many common foods, even big changes in concentration for single foods or groups of foods would probably have a small impact on overall population-based intake and risk. These results suggest that a more holistic analysis of dietary cancer risks may be appropriate, by which potential risks from AA should be considered in conjunction with other risks and benefits from foods. JF - Journal of agricultural and food chemistry AU - Doerge, Daniel R AU - Young, John F AU - Chen, James J AU - Dinovi, Michael J AU - Henry, Sara H AD - National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA. daniel.doerge@fda.hhs.gov Y1 - 2008/08/13/ PY - 2008 DA - 2008 Aug 13 SP - 6031 EP - 6038 VL - 56 IS - 15 KW - Carcinogens KW - 0 KW - Acrylamide KW - 20R035KLCI KW - Index Medicus KW - Hot Temperature KW - Animals KW - Humans KW - Carcinogens -- chemistry KW - Neoplasms -- chemically induced KW - Food Contamination -- analysis KW - Environmental Exposure -- analysis KW - Risk Assessment KW - Acrylamide -- pharmacology KW - Diet KW - Acrylamide -- pharmacokinetics KW - Models, Biological KW - Acrylamide -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69398135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Using+dietary+exposure+and+physiologically+based+pharmacokinetic%2Fpharmacodynamic+modeling+in+human+risk+extrapolations+for+acrylamide+toxicity.&rft.au=Doerge%2C+Daniel+R%3BYoung%2C+John+F%3BChen%2C+James+J%3BDinovi%2C+Michael+J%3BHenry%2C+Sara+H&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2008-08-13&rft.volume=56&rft.issue=15&rft.spage=6031&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Fjf073042g LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-29 N1 - Date created - 2008-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf073042g ER - TY - JOUR T1 - Acrylamide: a dietary carcinogen formed in vivo? AN - 69397763; 18624427 AB - Acrylamide, a chemical formed during heating of human foods, reacts with N-terminal valine in hemoglobin (Hb) and forms stable reaction products (adducts). These adducts to N-terminal valine in Hb have been used to estimate daily intake of acrylamide. Daily intake of acrylamide estimated from Hb adduct levels was higher than daily intake estimated from dietary questionnaires, possibly indicating other sources of exposures. Therefore, in this study the possible endogenous formation of acrylamide was investigated by treating mice with FeSO 4, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-hydrochloric acid (MPTP), or methamphetamine (METH). Acrylamide Hb adducts were determined, and a significant increase ( p < 0.05) in acrylamide Hb adduct levels was observed 24 h following treatment with FeSO 4 and 72 h following treatment with MPTP or METH. The results of this study show that acrylamide Hb adduct levels are increased in mice treated with compounds known to induce free radicals, thus suggesting the endogenous production of acrylamide. JF - Journal of agricultural and food chemistry AU - Tareke, Eden AU - Lyn-Cook, Beverly AU - Robinson, Bonnie AU - Ali, Syed F AD - Division of Personalized Nutrition and Medicine, Toxicologic Pathology Association, Inc., Jefferson, Arkansas 72079, USA. eden.tareke@fda.hhs.gov Y1 - 2008/08/13/ PY - 2008 DA - 2008 Aug 13 SP - 6020 EP - 6023 VL - 56 IS - 15 KW - Carcinogens KW - 0 KW - Ferrous Compounds KW - Hemoglobins KW - Acrylamide KW - 20R035KLCI KW - ferrous sulfate KW - 39R4TAN1VT KW - Methamphetamine KW - 44RAL3456C KW - Globins KW - 9004-22-2 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Valine KW - HG18B9YRS7 KW - Index Medicus KW - Globins -- isolation & purification KW - Animals KW - Ferrous Compounds -- pharmacology KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- pharmacology KW - Mice, Inbred C57BL KW - Methamphetamine -- pharmacology KW - Mice KW - Hemoglobins -- chemistry KW - Diet KW - Globins -- chemistry KW - Valine -- chemistry KW - Male KW - Hot Temperature KW - Acrylamide -- chemical synthesis KW - Food Analysis KW - Food Handling -- methods KW - Acrylamide -- blood KW - Acrylamide -- administration & dosage KW - Carcinogens -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69397763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Acrylamide%3A+a+dietary+carcinogen+formed+in+vivo%3F&rft.au=Tareke%2C+Eden%3BLyn-Cook%2C+Beverly%3BRobinson%2C+Bonnie%3BAli%2C+Syed+F&rft.aulast=Tareke&rft.aufirst=Eden&rft.date=2008-08-13&rft.volume=56&rft.issue=15&rft.spage=6020&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Fjf703749h LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-29 N1 - Date created - 2008-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf703749h ER - TY - GEN T1 - Child Welfare Outcomes 2002-2005. Report to Congress AN - 61982754; ED502956 AB - "Child Welfare Outcomes 2002-2005: Report to Congress" (Child Welfare Outcomes Report) is the seventh in a series of annual reports from the U.S. Department of Health and Human Services (the Department). The reports are developed in accordance with section 479A of the Social Security Act (as amended by the Adoption and Safe Families Act of 1997) and provide information pertaining to State performance on the following national child welfare outcomes: (1) Reduce recurrence of child abuse and/or neglect; (2) Reduce the incidence of child abuse and/or neglect in foster care; (3) Increase permanency for children in foster care; (4) Reduce time in foster care to reunification without increasing reentry; (5) Reduce time in foster care to adoption; (6) Increase placement stability; and (7) Reduce placements of young children in group homes or institutions. The outcomes reflect widely accepted performance objectives for child welfare practice. They were established by the Department in consultation with state and local child welfare agency administrators, child advocacy organizations, child welfare researchers, State legislators, and other experts in the child welfare field. The Child Welfare Outcomes Reports are designed to inform Congress, the states, and the public about state performance on key child welfare outcomes and change in performance over time. The underlying goal of the reports is to promote continuous improvement in the outcomes experienced by children served by child welfare systems throughout the nation. Five appendixes are included: (1) Adoption and Safe Families Act of 1997 (Public Law 105-89), Section 203(A); (2) Child Welfare Outcomes and Measures; (3) Data Sources and Data Elements; (4) Highlights of "Child Maltreatment 2005"; and (5) Annual AFCARS (Adoption and Foster Care Analysis and Reporting System) Report. (Contains 67 footnotes and 17 tables. Additional references, footnotes and tables are included on a state-by state basis.) Y1 - 2008/08/13/ PY - 2008 DA - 2008 Aug 13 SP - 532 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - Adoption and Safe Families Act 1997 KW - Social Security Act KW - ERIC, Resources in Education (RIE) KW - Adoption KW - Institutions KW - Annual Reports KW - Group Homes KW - Foster Care KW - Child Welfare KW - Child Safety KW - Placement KW - Federal Legislation KW - Social Services KW - Child Neglect KW - Incidence KW - Performance KW - Child Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61982754?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - CPAPER T1 - Immunosuppressive protocols to improve long term outcomes T2 - 22nd International Congress of the Transplantation Society AN - 41088362; 4938465 JF - 22nd International Congress of the Transplantation Society AU - Cavaille-Coll, Marc W AU - Norman, Douglas AU - Vanrenterghem, Yves Y1 - 2008/08/10/ PY - 2008 DA - 2008 Aug 10 KW - Immunosuppression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41088362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+International+Congress+of+the+Transplantation+Society&rft.atitle=Immunosuppressive+protocols+to+improve+long+term+outcomes&rft.au=Cavaille-Coll%2C+Marc+W%3BNorman%2C+Douglas%3BVanrenterghem%2C+Yves&rft.aulast=Cavaille-Coll&rft.aufirst=Marc&rft.date=2008-08-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+International+Congress+of+the+Transplantation+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.transplantation2008.org/sota_program.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Need for Improved Sample Prep Methods T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41078733; 4919837 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Tortorello, Mary Lou Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Sampling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41078733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=The+Need+for+Improved+Sample+Prep+Methods&rft.au=Tortorello%2C+Mary+Lou&rft.aulast=Tortorello&rft.aufirst=Mary&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of the Combination of pH, Water Activity and Temperature on the Germination of Bacillus anthracis Spores T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41077270; 4920154 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Hao, Yun Yun Diana AU - Whiting, Richard C Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Germination KW - Temperature effects KW - PH KW - PH effects KW - Water temperature KW - Water activity KW - Spores KW - Abiotic factors KW - Bacillus anthracis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41077270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=Effect+of+the+Combination+of+pH%2C+Water+Activity+and+Temperature+on+the+Germination+of+Bacillus+anthracis+Spores&rft.au=Hao%2C+Yun+Yun+Diana%3BWhiting%2C+Richard+C&rft.aulast=Hao&rft.aufirst=Yun+Yun&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fish Consumption by Mothers of Infants and by Women of Childbearing Age T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41077025; 4919818 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Choiniere, Conrad J AU - Timbo, Babgaleh AU - Street, Debra AU - Trumbo, Paula AU - Fein, Sara Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Infants KW - Age KW - Fish consumption UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41077025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=Fish+Consumption+by+Mothers+of+Infants+and+by+Women+of+Childbearing+Age&rft.au=Choiniere%2C+Conrad+J%3BTimbo%2C+Babgaleh%3BStreet%2C+Debra%3BTrumbo%2C+Paula%3BFein%2C+Sara&rft.aulast=Choiniere&rft.aufirst=Conrad&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Salmonella Factors Affecting Resistance to Non-Thermal Processes T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41076356; 4919942 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Larkin, John W Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41076356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=Salmonella+Factors+Affecting+Resistance+to+Non-Thermal+Processes&rft.au=Larkin%2C+John+W&rft.aulast=Larkin&rft.aufirst=John&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sanitary Design: Cross-Contamination Issues in Liquid Food Transportation T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41076024; 4919851 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Kashtock, Michael E Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Transportation KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41076024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=Sanitary+Design%3A+Cross-Contamination+Issues+in+Liquid+Food+Transportation&rft.au=Kashtock%2C+Michael+E&rft.aulast=Kashtock&rft.aufirst=Michael&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficacy of Electrolyzed Oxidizing Water Against Listeria monocytogenes and Morganella morganii Biofilms T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41075083; 4919823 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - McCarthy, Usan AU - Bencsath, Aladar AU - Johnson, Deborah Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Biofilms KW - Morganella morganii KW - Listeria monocytogenes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41075083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=Efficacy+of+Electrolyzed+Oxidizing+Water+Against+Listeria+monocytogenes+and+Morganella+morganii+Biofilms&rft.au=McCarthy%2C+Usan%3BBencsath%2C+Aladar%3BJohnson%2C+Deborah&rft.aulast=McCarthy&rft.aufirst=Usan&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence and Antimicrobial Resistance of Salmonella Isolated from Retail Meat: National Antimicrobial Resistance Monitoring System (NARMS): 20022006 T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41074925; 4919933 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Zhao, Shaohua AU - Glenn, Althea AU - Friedman, Sharon L AU - Abbott, Jason W AU - Ayers, Sherry AU - Hall-Robinson, Elvira AU - McDermott, P F Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Antimicrobial agents KW - Antimicrobial resistance KW - Meat KW - Monitoring systems KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41074925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=Prevalence+and+Antimicrobial+Resistance+of+Salmonella+Isolated+from+Retail+Meat%3A+National+Antimicrobial+Resistance+Monitoring+System+%28NARMS%29%3A+20022006&rft.au=Zhao%2C+Shaohua%3BGlenn%2C+Althea%3BFriedman%2C+Sharon+L%3BAbbott%2C+Jason+W%3BAyers%2C+Sherry%3BHall-Robinson%2C+Elvira%3BMcDermott%2C+P+F&rft.aulast=Zhao&rft.aufirst=Shaohua&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Equivalence and International Comparison of Food Safety Systems WHO Perspective T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41074923; 4919953 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Buchanan, Robert L Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Food contamination KW - Food KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41074923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=Equivalence+and+International+Comparison+of+Food+Safety+Systems+WHO+Perspective&rft.au=Buchanan%2C+Robert+L&rft.aulast=Buchanan&rft.aufirst=Robert&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Food Allergens: Current Understanding and Impact of Processing T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41074858; 4920275 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Fu, Tong-Jen Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Allergens KW - Food hypersensitivity KW - Processing fishery products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41074858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=Food+Allergens%3A+Current+Understanding+and+Impact+of+Processing&rft.au=Fu%2C+Tong-Jen&rft.aulast=Fu&rft.aufirst=Tong-Jen&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A National Review of Irrigation Water Practices T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41074472; 4920067 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Fogg, Norman Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Reviews KW - Irrigation water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41074472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=A+National+Review+of+Irrigation+Water+Practices&rft.au=Fogg%2C+Norman&rft.aulast=Fogg&rft.aufirst=Norman&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enterotoxigenicity and Other Metabolic Characteristics of Staphylococcus Species T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41074278; 4920151 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Hait, Jennifer M AU - Bennett, Reginald W Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Laboratory methods KW - Pathogens KW - Staphylococcus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41074278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=Enterotoxigenicity+and+Other+Metabolic+Characteristics+of+Staphylococcus+Species&rft.au=Hait%2C+Jennifer+M%3BBennett%2C+Reginald+W&rft.aulast=Hait&rft.aufirst=Jennifer&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Resistance to Third Generation Cephalosporins in Salmonella Isolated from NARMS Retail Meats T2 - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AN - 41071319; 4920267 JF - 95th Annual Meeting of the International Association for Food Protection (IAFP 2008) AU - Zhao, Shaohua Y1 - 2008/08/03/ PY - 2008 DA - 2008 Aug 03 KW - Meat KW - Cephalosporins KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41071319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.atitle=Resistance+to+Third+Generation+Cephalosporins+in+Salmonella+Isolated+from+NARMS+Retail+Meats&rft.au=Zhao%2C+Shaohua&rft.aulast=Zhao&rft.aufirst=Shaohua&rft.date=2008-08-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202008/Full%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Estimating Community Drug Abuse by Wastewater Analysis AN - 743480545; 201004-31-0307846 (CE); 12110178 (EN) AB - BACKGROUND: The social and medical problems of drug abuse are a matter of increasing global concern. To tackle drug abuse in changing scenarios, international drug agencies need fresh methods to monitor trends and patterns of illicit drug consumption. OBJECTIVE: We tested a sewage epidemiology approach, using levels of excreted drug residues in wastewater, to monitor collective use of the major drugs of abuse in near real time. METHODS: Selected drug target residues derived from use of cocaine, opiates, cannabis, and amphetamines were measured by mass spectrometry in wastewater collected at major sewage treatment plants in Milan (Italy), Lugano (Switzerland), and London (United Kingdom). The amounts of drug residues conveyed to the treatment plants, reflecting the amounts collectively excreted with urine, were used to estimate consumption of the active parent drugs. RESULTS: Reproducible and characteristic profiles of illicit drug use were obtained in the three cities, thus for the first time quickly revealing changes in local consumption (e.g., cocaine consumption rose significantly on weekends in Milan). Profiles of local drug consumption based on waste-water measurements are in line with national annual prevalence estimates. CONCLUSIONS: Patterns and trends of drug abuse in local communities can be promptly monitored by this tool, a convenient new complement to more complex, lengthy survey methods. In principle, searching the sewage for excreted compounds relevant to public health issues appears to have the potential to become a convenient source of real-time epidemiologic information. JF - Environmental Health Perspectives AU - Zuccato, Ettore AU - Chiabrando, Chiara AU - Castiglioni, Sara AU - Bagnati, Renzo AU - Fanelli, Roberto PY - 2008 SP - 1027 EP - 1032 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Drugs KW - Waste water KW - Drug abuse KW - Residues KW - Monitors KW - Epidemiology KW - Estimates KW - Health KW - Communities KW - Sewage KW - Illicit KW - Real time KW - Trends KW - Searching KW - Estimating KW - Cannabis KW - Tools KW - Complement KW - Medical KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743480545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Estimating+Community+Drug+Abuse+by+Wastewater+Analysis&rft.au=Zuccato%2C+Ettore%3BChiabrando%2C+Chiara%3BCastiglioni%2C+Sara%3BBagnati%2C+Renzo%3BFanelli%2C+Roberto&rft.aulast=Zuccato&rft.aufirst=Ettore&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1027&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Use of Space-Time Models to Investigate the Stability of Patterns of Disease AN - 743441092; 201004-31-0307834 (CE); 12110166 (EN) AB - BACKGROUND: The use of Bayesian hierarchical spatial models has become widespread in disease mapping and ecologic studies of health-environment associations. In this type of study, the data are typically aggregated over an extensive time period, thus neglecting the time dimension. The output of purely spatial disease mapping studies is therefore the average spatial pattern of risk over the period analyzed, but the results do not inform about, for example, whether a high average risk was sustained over time or changed over time. OBJECTIVE: We investigated how including the time dimension in disease-mapping models strengthens the epidemiologic interpretation of the overall pattern of risk. METHODS: We discuss a class of Bayesian hierarchical models that simultaneously characterize and estimate the stable spatial and temporal patterns as well as departures from these stable components. We show how useful rules for classifying areas as stable can be constructed based on the posterior distribution of the space-time interactions. We carry out a simulation study to investigate the sensitivity and specificity of the decision rules we propose, and we illustrate our approach in a case study of congenital anomalies in England. RESULTS: Our results confirm that extending hierarchical disease-mapping models to models that simultaneously consider space and time leads to a number of benefits in terms of interpretation and potential for detection of localized excesses. JF - Environmental Health Perspectives AU - Abellan, Juan Jose AU - Richardson, Sylvia AU - Best, Nicky PY - 2008 SP - 1111 EP - 1119 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Bayesian analysis KW - Health KW - Mapping KW - Ecological monitoring KW - Congenital anomalies KW - Copyrights KW - Classification KW - Temporal logic KW - Computer simulation KW - Estimates KW - Stability KW - Mathematical models KW - Epidemiology KW - Construction KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743441092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Use+of+Space-Time+Models+to+Investigate+the+Stability+of+Patterns+of+Disease&rft.au=Abellan%2C+Juan+Jose%3BRichardson%2C+Sylvia%3BBest%2C+Nicky&rft.aulast=Abellan&rft.aufirst=Juan&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Road Proximity Increases Risk of Skeletal Abnormalities in Wood Frogs from National Wildlife Refuges in Alaska AN - 743424993; 201004-31-0307849 (CE); 12110181 (EN) AB - BACKGROUND: Skeletal and eye abnormalities in amphibians are not well understood, and they appear to be increasing while global populations decline. Here, we present the first study of amphibian abnormalities in Alaska. OBJECTIVE: In this study we investigated the relationship between anthropogenic influences and the probability of skeletal and eye abnormalities in Alaskan wood frogs (Rana sylvatica). METHODS: From 2000 to 2006, we examined 9,269 metamorphic wood frogs from 86 breeding sites on five National Wildlife Refuges: Arctic, Innoko, Kenai, Tetlin, and Yukon Delta. Using road proximity as a proxy for human development, we tested relationships between skeletal and eye abnormalities and anthropogenic effects. We also examined a subsample of 458 frogs for the trematode parasite Ribeiroia ondatrae, a known cause of amphibian limb abnormalities. RESULTS: Prevalence of skeletal and eye abnormalities at Alaskan refuges ranged from 1.5% to 7.9% and were as high as 20% at individual breeding sites. Proximity to roads increased the risk of skeletal abnormalities (p = 0.004) but not eye abnormalities. The only significant predictor of eye abnormalities was year sampled (p = 0.006). R. ondatrae was not detected in any Alaskan wood frogs. CONCLUSIONS: Abnormality prevalence at road-accessible sites in the Kenai and Tetlin refuges is among the highest reported in the published literature. Proximity to roads is positively correlated with risk of skeletal abnormalities in Alaskan wood frogs. JF - Environmental Health Perspectives AU - Reeves, Mari K AU - Dolph, Christine L AU - Zimmer, Heidi AU - Tjeerdema, Ronald S AU - Trust, Kimberly A PY - 2008 SP - 1009 EP - 1014 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Abnormalities KW - Frogs KW - Wood KW - Roads KW - Proximity KW - Risk KW - Refuges KW - Health KW - Wildlife refuges KW - Correlation KW - Populations KW - Proxy client servers KW - Metamorphic KW - Parasites KW - Copyrights KW - Limbs KW - Human KW - Deltas KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743424993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Road+Proximity+Increases+Risk+of+Skeletal+Abnormalities+in+Wood+Frogs+from+National+Wildlife+Refuges+in+Alaska&rft.au=Reeves%2C+Mari+K%3BDolph%2C+Christine+L%3BZimmer%2C+Heidi%3BTjeerdema%2C+Ronald+S%3BTrust%2C+Kimberly+A&rft.aulast=Reeves&rft.aufirst=Mari&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1009&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Relation between Cord Blood Mercury Levels and Early Child Development in a World Trade Center Cohort AN - 743417506; 201004-31-0307838 (CE); 12110170 (EN) AB - OBJECTIVE: This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development. METHODS: We determined maternal and umbilical cord blood total mercury of nonsmoking women who delivered at term in lower Manhattan after 11 September 2001, and measured birth outcomes and child development. RESULTS: Levels of total mercury in cord and maternal blood were not significantly higher for women who resided or worked within 1 or 2 miles of the WTC in the month after 11 September, compared with women who lived and worked farther away. Average cord mercury levels were more than twice maternal levels, and both were elevated in women who reported eating fish/seafood during pregnancy. Regression analyses showed no significant association between (ln) cord or maternal blood total mercury and birth outcomes. Log cord mercury was inversely associated with the Bayley Scales of Infant Development psychomotor score [Psychomotor Development Index (PDI)] at 36 months (b = -4.2, p = 0.007) and with Performance (b = -3.4, p = 0.023), Verbal (b = -2.9, p = 0.023), and Full IQ scores (b = -3.8, p = 0.002) on the Wechsler Preschool and Primary Scale of Intelligence, Revised (WPPSI-R), at 48 months, after controlling for fish/seafood consumption and other confounders. Fish/seafood consumption during pregnancy was significantly associated with a 5.6- to 9.9-point increase in 36-month PDI, and 48-month Verbal and Full IQ scores. CONCLUSIONS: Blood mercury was not significantly raised in women living or working close to the WTC site in the weeks after 11 September 2001. Higher cord blood mercury was associated with reductions in developmental scores at 36 and 48 months, after adjusting for the positive effects of fish/seafood consumption during pregnancy. JF - Environmental Health Perspectives AU - Lederman, Sally Ann AU - Jones, Robert L AU - Caldwell, Kathleen L AU - Rauh, Virginia AU - Sheets, Stephen E AU - Tang, Deliang AU - Viswanathan, Sheila AU - Becker, Mark AU - Stein, Janet L AU - Wang, Richard Y AU - Perera, Frederica P PY - 2008 SP - 1085 EP - 1091 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mercury KW - Blood KW - Rope KW - Fish KW - Seafood KW - Pregnancy KW - Health KW - Birth KW - Copyrights KW - Umbilical cords KW - Intelligence KW - Eating KW - Elevated KW - Disasters KW - Infants KW - Regression analysis KW - Reduction KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743417506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Relation+between+Cord+Blood+Mercury+Levels+and+Early+Child+Development+in+a+World+Trade+Center+Cohort&rft.au=Lederman%2C+Sally+Ann%3BJones%2C+Robert+L%3BCaldwell%2C+Kathleen+L%3BRauh%2C+Virginia%3BSheets%2C+Stephen+E%3BTang%2C+Deliang%3BViswanathan%2C+Sheila%3BBecker%2C+Mark%3BStein%2C+Janet+L%3BWang%2C+Richard+Y%3BPerera%2C+Frederica+P&rft.aulast=Lederman&rft.aufirst=Sally&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1085&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Protective Effects of B Vitamins and Antioxidants on the Risk of Arsenic-Related Skin Lesions in Bangladesh AN - 743393265; 201004-31-0307842 (CE); 12110174 (EN) AB - BACKGROUND: An estimated 25-40 million of the 127 million people of Bangladesh have been exposed to high levels of naturally occurring arsenic from drinking groundwater. The mitigating effects of diet on arsenic-related premalignant skin lesions are largely unknown. OBJECTIVES: The purpose of this study was to clarify the effects of the vitamin B group (thiamin, riboflavin, niacin, pyridoxine, and cobalamin) and antioxidants (vitamins A, C, and E) on arsenic-related skin lesions. METHODS: We performed a cross-sectional study using baseline data from the Health Effects of Arsenic Longitudinal Study (HEALS), 2000-2002, with individual-level, time-weighted measures of arsenic exposure from drinking water. A total of 14,828 individuals meeting a set of eligibility criteria were identified among 65,876 users of all 5,996 tube wells in the 25-km(2) area of Araihazar, Bangladesh; 11,746 were recruited into the study. This analysis is based on 10,628 subjects (90.5%) with nonmissing dietary data. Skin lesions were identified according to a structured clinical protocol during screening and confirmed with further clinical review. RESULTS: Riboflavin, pyridoxine, folic acid, and vitamins A, C, and E significantly modified risk of arsenic-related skin lesions. The deleterious effect of ingested arsenic, at a given exposure level, was significantly reduced (ranging from 46% reduction for pyridoxine to 68% for vitamin C) for persons in the highest quintiles of vitamin intake. CONCLUSIONS: Intakes of B-vitamins and antioxidants, at doses greater than the current recommended daily amounts for the country, may reduce the risk of arsenic-related skin lesions in Bangladesh. JF - Environmental Health Perspectives AU - Zablotska, Lydia B AU - Chen, Yu AU - Graziano, Joseph H AU - Parvez, Faruque AU - van Geen, Alexander AU - Howe, Geoffrey R AU - Ahsan, Habibul PY - 2008 SP - 1056 EP - 1062 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Arsenic KW - Lesions KW - Vitamins KW - Pyridoxine KW - Risk KW - Health KW - Antioxidants KW - Riboflavin KW - Intakes KW - Drinking water KW - Reduction KW - Protective KW - Vitamin C KW - Criteria KW - Tubes KW - Meetings KW - Diets KW - Groundwater KW - Drinking KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743393265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Protective+Effects+of+B+Vitamins+and+Antioxidants+on+the+Risk+of+Arsenic-Related+Skin+Lesions+in+Bangladesh&rft.au=Zablotska%2C+Lydia+B%3BChen%2C+Yu%3BGraziano%2C+Joseph+H%3BParvez%2C+Faruque%3Bvan+Geen%2C+Alexander%3BHowe%2C+Geoffrey+R%3BAhsan%2C+Habibul&rft.aulast=Zablotska&rft.aufirst=Lydia&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1056&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Prenatal Phenol and Phthalate Exposures and Birth Outcomes AN - 743389158; 201004-31-0307837 (CE); 12110169 (EN) AB - BACKGROUND: Many phthalates and phenols are hormonally active and are suspected to alter the course of development. OBJECTIVE: We investigated prenatal exposures to phthalate and phenol metabolites and their associations with body size measures of the infants at birth. METHODS: We measured 5 phenol and 10 phthalate urinary metabolites in a multiethnic cohort of 404 women in New York City during their third trimester of pregnancy and recorded size of infants at birth. RESULTS: Median urinary concentrations were 10 microg/L for 2 of 5 phenols and 6 of 10 phthalate monoester metabolites. Concentrations of low-molecular-weight phthalate monoesters (low-MWP) were approximately 5-fold greater than those of high-molecular-weight metabolites. Low-MWP metabolites had a positive association with gestational age [0.97 day gestational age per ln-biomarker; 95% confidence interval (CI), 0.07-1.9 days, multivariate adjusted] and with head circumference. Higher prenatal exposures to 2,5-dichlorophenol (2,5-DCP) predicted lower birth weight in boys (-210 g average birth weight difference between the third tertile and first tertile of 2,5-DCP; 95% CI, 71-348 g). Higher maternal benzophenone-3 (BP3) concentrations were associated with a similar decrease in birth weight among girls but with greater birth weight in boys. CONCLUSIONS: We observed a range of phthalate and phenol exposures during pregnancy in our population, but few were associated with birth size. The association of 2,5-DCP and BP3 with reduced or increased birth weight could be important in very early or small-size births. In addition, positive associations of urinary metabolites with some outcomes may be attributable partly to unresolved confounding with maternal anthropometric factors. JF - Environmental Health Perspectives AU - Wolff, Mary S AU - Engel, Stephanie M AU - Berkowitz, Gertrud S AU - Ye, Xiaoyun AU - Silva, Manori J AU - Zhu, Chenbo AU - Wetmur, James AU - Calafat, Antonia M PY - 2008 SP - 1092 EP - 1097 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Birth KW - Phthalates KW - Metabolites KW - Phenol KW - Exposure KW - Infants KW - Health KW - Age KW - Pregnancy KW - Weight reduction KW - Confidence intervals KW - Copyrights KW - Circumferences KW - Girls KW - Adjustment KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743389158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prenatal+Phenol+and+Phthalate+Exposures+and+Birth+Outcomes&rft.au=Wolff%2C+Mary+S%3BEngel%2C+Stephanie+M%3BBerkowitz%2C+Gertrud+S%3BYe%2C+Xiaoyun%3BSilva%2C+Manori+J%3BZhu%2C+Chenbo%3BWetmur%2C+James%3BCalafat%2C+Antonia+M&rft.aulast=Wolff&rft.aufirst=Mary&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1092&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Pentachlorophenol and Cancer Risk: Focusing the Lens on Specific Chlorophenols and Contaminants AN - 743382762; 201004-31-0307850 (CE); 12110182 (EN) AB - OBJECTIVE: Pentachlorophenol, a fungicide widely used as a wood preservative, was classified in 1999 by the International Agency for Research on Cancer as a possible human carcinogen. We reviewed currently available data to determine the extent to which recent studies assist in distinguishing the effect of pentachlorophenol from that of its contaminants (e.g., dioxins and other chlorophenols). DATA SOURCES AND EXTRACTION: We performed a systematic review of published studies pertaining to cancer risk in relation to pentachlorophenol exposure, focusing on results pertaining specifically to all cancer sites and specific hematopoietic cancers, and data pertaining to risks associated with other types of chlorophenols, dioxins, or furans. SYNTHESIS: The pentachlorophenol studies presented considerable evidence pertaining to hematopoietic cancers, with strong associations seen in multiple studies, in different locations, and using different designs. There is little evidence of an association between these cancers and chlorophenols that contain fewer than four chlorines. The extension of a large cohort study of sawmill workers, with follow-up to 1995, provided information about risks of relatively rare cancers (e.g., non-Hodgkin lymphoma, multiple myeloma), using a validated exposure assessment procedure that distinguishes between exposures to pentachlorophenol and tetrachlorophenol. In contrast with dioxin, pentachlorophenol exposure has not been associated with total cancer incidence or mortality. CONCLUSIONS: The updated cohort study focusing on pentachlorophenol provides increased statistical power and precision, and demonstrates associations between hematopoietic cancer and pentachlorophenol exposure not observed in earlier evaluations of this cohort. Contaminant confounding is an unlikely explanation for the risks seen with pentachlorophenol exposure. JF - Environmental Health Perspectives AU - Cooper, Glinda S AU - Jones, Samantha PY - 2008 SP - 1001 EP - 1008 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Pentachlorophenol KW - Cancer KW - Risk KW - Chlorophenols KW - Focusing KW - Contaminants KW - Dioxins KW - Health KW - Wood KW - Fungicides KW - Assessments KW - Carcinogens KW - Extraction KW - Sawmills KW - Data sources KW - Mortality KW - Lenses KW - Preservatives KW - Synthesis KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743382762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Pentachlorophenol+and+Cancer+Risk%3A+Focusing+the+Lens+on+Specific+Chlorophenols+and+Contaminants&rft.au=Cooper%2C+Glinda+S%3BJones%2C+Samantha&rft.aulast=Cooper&rft.aufirst=Glinda&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1001&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Interactions between Glutathione S-Transferase P1, Tumor Necrosis Factor, and Traffic-Related Air Pollution for Development of Childhood Allergic Disease AN - 743347222; 201004-31-0307839 (CE); 12110171 (EN) AB - BACKGROUND: Air pollutants may induce airway inflammation and sensitization due to generation of reactive oxygen species. The genetic background to these mechanisms could be important effect modifiers. OBJECTIVE: Our goal was to assess interactions between exposure to air pollution and single nucleotide polymorphisms (SNPs) in the beta2-adrenergic receptor (ADRB2), glutathione S-transferase P1 (GSTP1), and tumor necrosis factor (TNF) genes for development of childhood allergic disease. METHODS: In a birth cohort originally of 4,089 children, we assessed air pollution from local traffic using nitrogen oxides (traffic NO(x)) as an indicator based on emission databases and dispersion modeling and estimated individual exposure through geocoding of home addresses. We measured peak expiratory flow rates and specific IgE for inhalant and food allergens at 4 years of age, and selected children with asthma symptoms up to 4 years of age (n = 542) and controls (n = 542) for genotyping. RESULTS: Interaction effects on allergic sensitization were indicated between several GSTP1 SNPs and traffic NO(x) exposure during the first year of life (p(nominal) 0.001-0.06). Children with Ile105Val/Val105Val genotypes were at increased risk of sensitization to any allergen when exposed to elevated levels of traffic NO(x) (for a difference between the 5th and 95th percentile of exposure: odds ratio = 2.4; 95% confidence interval, 1.0-5.3). In children with TNF-308 GA/AA genotypes, the GSTP1-NO(x) interaction effect was even more pronounced. We observed no conclusive interaction effects for ADRB2. CONCLUSION: The effect of air pollution from traffic on childhood allergy appears to be modified by GSTP1 and TNF variants, supporting a role of genes controlling the antioxidative system and inflammatory response in allergy. JF - Environmental Health Perspectives AU - Melen, Erik AU - Nyberg, Fredrik AU - Lindgren, Cecilia M AU - Berglind, Niklas AU - Zucchelli, Marco AU - Nordling, Emma AU - Hallberg, Jenny AU - Svartengren, Magnus AU - Morgenstern, Ralf AU - Kere, Juha AU - Bellander, Tom AU - Wickman, Magnus AU - Pershagen, Goeran PY - 2008 SP - 1077 EP - 1084 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Traffic flow KW - Traffic engineering KW - Air pollution KW - Children KW - Mathematical models KW - Glutathione KW - Allergic diseases KW - Tumors KW - Health KW - Genes KW - Age KW - Genetic algorithms KW - Asthma KW - Dispersions KW - Risk KW - Inflammatory response KW - Flow rate KW - Emission analysis KW - Nitrogen oxides KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743347222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Interactions+between+Glutathione+S-Transferase+P1%2C+Tumor+Necrosis+Factor%2C+and+Traffic-Related+Air+Pollution+for+Development+of+Childhood+Allergic+Disease&rft.au=Melen%2C+Erik%3BNyberg%2C+Fredrik%3BLindgren%2C+Cecilia+M%3BBerglind%2C+Niklas%3BZucchelli%2C+Marco%3BNordling%2C+Emma%3BHallberg%2C+Jenny%3BSvartengren%2C+Magnus%3BMorgenstern%2C+Ralf%3BKere%2C+Juha%3BBellander%2C+Tom%3BWickman%2C+Magnus%3BPershagen%2C+Goeran&rft.aulast=Melen&rft.aufirst=Erik&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1077&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Maternal and Gestational Risk Factors for Hypospadias AN - 743310744; 201004-31-0307840 (CE); 12110172 (EN) AB - BACKGROUND: An increase in the prevalence of hypospadias has been reported, but the environmental causes remain virtually unknown. OBJECTIVES: Our goal was to assess the association between risk of hypospadias and indicators of placental function and endogenous hormone levels, exposure to exogenous hormones, maternal diet during pregnancy, and other environmental factors. METHODS: We conducted a case-control study in Sweden and Denmark from 2000 through 2005 using self-administered questionnaires completed by mothers of hypospadias cases and matched controls. The response rate was 88% and 81% among mothers of cases and controls, respectively. The analyses included 292 cases and 427 controls. RESULTS: A diet during pregnancy lacking both fish and meat was associated with a more than 4-fold increased risk of hypospadias [odds ratio (OR) = 4.6; 95% confidence interval (CI), 1.6-13.3]. Boys born to obese [body mass index (BMI) or = 30] women had a more than 2-fold increased risk of hypospadias (OR = 2.6; 95% CI, 1.2-5.7) compared with boys born to mothers with a normal weight (BMI = 20-24). Maternal hypertension during pregnancy and absence of maternal nausea increased a boy's risk of hypospadias 2.0-fold (95% CI, 1.1-3.7) and 1.8-fold (95% CI, 1.2-2.8), respectively. Nausea in late pregnancy also appeared to be positively associated with hypospadias risk (OR = 7.6; 95% CI, 1.1-53). CONCLUSIONS: A pregnancy diet lacking meat and fish appears to increase the risk of hypospadias in the offspring. Other risk associations were compatible with a role for placental insufficiency in the etiology of hypospadias. JF - Environmental Health Perspectives AU - Akre, Olof AU - Boyd, Heather A AU - Ahlgren, Martin AU - Wilbrand, Kerstin AU - Westergaard, Tine AU - Hjalgrim, Henrik AU - Nordenskjoeld, Agneta AU - Ekbom, Anders AU - Melbye, Mads PY - 2008 SP - 1071 EP - 1076 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Pregnancy KW - Diets KW - Control equipment KW - Fish KW - Meat KW - Bismaleimides KW - Hormones KW - Nausea KW - Health KW - Hypertension KW - Ecological risk assessment KW - Confidence intervals KW - Copyrights KW - Compatibility KW - Indicators KW - Etiology KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743310744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Maternal+and+Gestational+Risk+Factors+for+Hypospadias&rft.au=Akre%2C+Olof%3BBoyd%2C+Heather+A%3BAhlgren%2C+Martin%3BWilbrand%2C+Kerstin%3BWestergaard%2C+Tine%3BHjalgrim%2C+Henrik%3BNordenskjoeld%2C+Agneta%3BEkbom%2C+Anders%3BMelbye%2C+Mads&rft.aulast=Akre&rft.aufirst=Olof&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1071&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Methodologic Issues and Approaches to Spatial Epidemiology AN - 743305372; 201004-31-0307835 (CE); 12110167 (EN) AB - Spatial epidemiology is increasingly being used to assess health risks associated with environmental hazards. Risk patterns tend to have both a temporal and a spatial component; thus, spatial epidemiology must combine methods from epidemiology, statistics, and geographic information science. Recent statistical advances in spatial epidemiology include the use of smoothing in risk maps to create an interpretable risk surface, the extension of spatial models to incorporate the time dimension, and the combination of individual- and area-level information. Advances in geographic information systems and the growing availability of modeling packages have led to an improvement in exposure assessment. Techniques drawn from geographic information science are being developed to enable the visualization of uncertainty and ensure more meaningful inferences are made from data. When public health concerns related to the environment arise, it is essential to address such anxieties appropriately and in a timely manner. Tools designed to facilitate the investigation process are being developed, although the availability of complete and clean health data, and appropriate exposure data often remain limiting factors. JF - Environmental Health Perspectives AU - Beale, Linda AU - Abellan, Juan Jose AU - Hodgson, Susan AU - Jarup, Lars PY - 2008 SP - 1105 EP - 1110 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Epidemiology KW - Risk KW - Health KW - Mathematical models KW - Availability KW - Assessments KW - Geographic information systems KW - Statistics KW - Constraining KW - Anxiety KW - Cleaning KW - Ecological risk assessment KW - Hazards KW - Satellite navigation systems KW - Copyrights KW - Packages KW - Visualization KW - Smoothing KW - Uncertainty KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743305372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Methodologic+Issues+and+Approaches+to+Spatial+Epidemiology&rft.au=Beale%2C+Linda%3BAbellan%2C+Juan+Jose%3BHodgson%2C+Susan%3BJarup%2C+Lars&rft.aulast=Beale&rft.aufirst=Linda&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1105&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Ambient Ozone Concentrations Cause Increased Hospitalizations for Asthma in Children: An 18-Year Study in Southern California AN - 743275742; 201004-31-0307841 (CE); 12110173 (EN) AB - BACKGROUND: Asthma is the most important chronic disease of childhood. The U.S. Environmental Protection Agency has concluded that children with asthma continue to be susceptible to ozone-associated adverse effects on their disease. OBJECTIVES: This study was designed to evaluate time trends in associations between declining warm-season O(3) concentrations and hospitalization for asthma in children. METHODS: We undertook an ecologic study of hospital discharges for asthma during the high O(3) seasons in California's South Coast Air Basin (SoCAB) in children who ranged in age from birth to 19 years from 1983 to 2000. We used standard association and causal statistical analysis methods. Hospital discharge data were obtained from the State of California; air pollution data were obtained from the California Air Resources Board, and demographic data from the 1980, 1990, and 2000 U.S. Census. SoCAB was divided into 195 spatial grids, and quarterly average O(3), sulfurdioxide, particulate matter with aerodynamic diameter or = 10 microm, nitrogen dioxide, and carbon monoxide were assigned to each unit for 3-month periods along with demographic variables. RESULTS: O(3) was the only pollutant associated with increased hospital admissions over the study period. Inclusion of a variety of demographic and weather variables accounted for all of the non-O(3) temporal changes in hospitalizations. We found a time-independent, constant effect of ambient levels of O(3) and quarterly hospital discharge rates for asthma. We estimate that the average effect of a 10-ppb mean increase in any given mean quarterly 1-hr maximum O(3) over the 18-year median of 87.7 ppb was a 4.6% increase in the same quarterly outcome. CONCLUSIONS: Our data indicate that at current levels of O(3) experienced in Southern California, O(3) contributes to an increased risk of hospitalization for children with asthma. JF - Environmental Health Perspectives AU - Moore, Kelly AU - Neugebauer, Romain AU - Lurmann, Fred AU - Hall, Jane AU - Brajer, Vic AU - Alcorn, Sianna AU - Tager, Ira PY - 2008 SP - 1063 EP - 1070 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Asthma KW - Children KW - Hospitals KW - Southern California KW - Health KW - Demographics KW - Air pollution KW - Inclusions KW - Nitrogen dioxide KW - Risk KW - Census KW - Estimates KW - Ecological monitoring KW - Weather KW - Climatology KW - Statistical analysis KW - Seasons KW - Standards KW - Basins KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743275742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Ambient+Ozone+Concentrations+Cause+Increased+Hospitalizations+for+Asthma+in+Children%3A+An+18-Year+Study+in+Southern+California&rft.au=Moore%2C+Kelly%3BNeugebauer%2C+Romain%3BLurmann%2C+Fred%3BHall%2C+Jane%3BBrajer%2C+Vic%3BAlcorn%2C+Sianna%3BTager%2C+Ira&rft.aulast=Moore&rft.aufirst=Kelly&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1063&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Genomic Profiling Reveals an Alternate Mechanism for Hepatic Tumor Promotion by Perfluorooctanoic Acid in Rainbow Trout AN - 743220045; 201004-31-0307843 (CE); 12110175 (EN) AB - BACKGROUND: Perfluorooctanoic acid (PFOA) is a potent hepatocarcinogen and peroxisome proliferator (PP) in rodents. Humans are not susceptible to peroxisome proliferation and are considered refractory to carcinogenesis by PPs. Previous studies with rainbow trout indicate they are also insensitive to peroxisome proliferation by the PP dehydroepiandrosterone (DHEA), but are still susceptible to enhanced hepatocarcinogenesis after chronic exposure. OBJECTIVES: In this study, we used trout as a unique in vivo tumor model to study the potential for PFOA carcinogenesis in the absence of peroxisome proliferation compared with the structurally diverse PPs clofibrate (CLOF) and DHEA. Mechanisms of carcinogenesis were identified from hepatic gene expression profiles phenotypically anchored to tumor outcome. METHODS: We fed aflatoxin B(1) or sham-initiated animals 200-1,800 ppm PFOA in the diet for 30 weeks for tumor analysis. We subsequently examined gene expression by cDNA array in animals fed PFOA, DHEA, CLOF, or 5 ppm 17beta-estradiol (E(2), a known tumor promoter) in the diet for 14 days. RESULTS: PFOA (1,800 ppm or 50 mg/kg/day) and DHEA treatments resulted in enhanced liver tumor incidence and multiplicity (p 0.0001), whereas CLOF showed no effect. Carcinogenesis was independent of peroxisome proliferation, measured by lack of peroxisomal beta-oxidation and catalase activity. Alternately, both tumor promoters, PFOA and DHEA, resulted in estrogenic gene signatures with strong correlation to E(2) by Pearson correlation (R = 0.81 and 0.78, respectively), whereas CLOF regulated no genes in common with E(2). CONCLUSIONS: These data suggest that the tumor-promoting activities of PFOA in trout are due to novel mechanisms involving estrogenic signaling and are independent of peroxisome proliferation. JF - Environmental Health Perspectives AU - Tilton, Susan C AU - Orner, Gayle A AU - Benninghoff, Abby D AU - Carpenter, Hillary M AU - Hendricks, Jerry D AU - Pereira, Cliff B AU - Williams, David E PY - 2008 SP - 1047 EP - 1055 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Tumors KW - Carcinogens KW - Trout KW - Gene expression KW - Polypropylenes KW - Correlation KW - Health KW - Diets KW - Genes KW - Animals KW - Rainbows KW - Catalase KW - Arrays KW - Aflatoxins KW - Signatures KW - Surgical implants KW - Biomedical materials KW - Promotion KW - Profiling KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743220045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Genomic+Profiling+Reveals+an+Alternate+Mechanism+for+Hepatic+Tumor+Promotion+by+Perfluorooctanoic+Acid+in+Rainbow+Trout&rft.au=Tilton%2C+Susan+C%3BOrner%2C+Gayle+A%3BBenninghoff%2C+Abby+D%3BCarpenter%2C+Hillary+M%3BHendricks%2C+Jerry+D%3BPereira%2C+Cliff+B%3BWilliams%2C+David+E&rft.aulast=Tilton&rft.aufirst=Susan&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1047&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Adverse Cardiovascular Effects with Acute Particulate Matter and Ozone Exposures: Interstrain Variation in Mice AN - 743183894; 201004-31-0307845 (CE); 12110177 (EN) AB - OBJECTIVES: Increased ambient particulate matter (PM) levels are associated with cardiovascular morbidity and mortality, as shown by numerous epidemiology studies. Few studies have investigated the role of copollutants, such as ozone, in this association. Furthermore, the mechanisms by which PM affects cardiac function remain uncertain. We hypothesized that PM and O(3) induce adverse cardiovascular effects in mice and that these effects are strain dependent. STUDY DESIGN: After implanting radiotelemeters to measure heart rate (HR) and HR variability (HRV) parameters, we exposed C57Bl/6J (B6), C3H/HeJ (HeJ), and C3H/HeOuJ (OuJ) inbred mouse strains to three different daily exposures of filtered air (FA), carbon black particles (CB), or O(3) and CB sequentially [O(3)CB; for CB, 536 +/- 24 microg/m(3); for O(3), 584 +/- 35 ppb (mean +/- SE)]. RESULTS: We observed significant changes in HR and HRV in all strains due to O(3)CB exposure, but not due to sequential FA and CB exposure (FACB). The data suggest that primarily acute HR and HRV effects occur during O(3)CB exposure, especially in HeJ and OuJ mice. For example, HeJ and OuJ mice demonstrated dramatic increases in HRV parameters associated with marked brady-cardia during O(3)CB exposure. In contrast, depressed HR responses occurred in B6 mice without detectable changes in HRV parameters. CONCLUSIONS: These findings demonstrate that important interstrain differences exist with respect to PM- and O(3)-induced cardiac effects. This interstrain variation suggests that genetic factors may modulate HR regulation in response to and recuperation from acute copollutant exposures. JF - Environmental Health Perspectives AU - Hamade, Ali K AU - Rabold, Richard AU - Tankersley, Clarke G PY - 2008 SP - 1033 EP - 1039 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Exposure KW - Mice KW - Strain KW - Health KW - Ozone KW - Genetics KW - Heart rate KW - Control KW - Copyrights KW - Mortality KW - Epidemiology KW - Carbon black KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743183894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Adverse+Cardiovascular+Effects+with+Acute+Particulate+Matter+and+Ozone+Exposures%3A+Interstrain+Variation+in+Mice&rft.au=Hamade%2C+Ali+K%3BRabold%2C+Richard%3BTankersley%2C+Clarke+G&rft.aulast=Hamade&rft.aufirst=Ali&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1033&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Diet and Nondiet Predictors of Urinary 3-Phenoxybenzoic Acid in NHANES 1999-2002 AN - 743180867; 201004-31-0307848 (CE); 12110180 (EN) AB - BACKGROUND: 3-Phenoxybenzoic acid (3PBA), a pyrethroid metabolite, was detected in 75% of urine samples analyzed for pesticides in the U.S. National Health and Nutrition Examination Survey (NHANES) 1999-2002. NHANES also includes 24-hr diet data and information on household pesticide use, activities, occupation, demographics, and other exposure factors. OBJECTIVES: The objective of our study was to explore the relative importance of diet versus nondiet predictors in explaining variability in urinary 3PBA. A secondary objective was to explore whether the NHANES data could be used to identify particular foods driving 3PBA levels. METHODS: We divided subjects into child (6-10 years of age), teen (11-18 years), and adult ( or = 19 years) age groups and restricted our analyses to subjects in the morning sampling session who fasted for or = 8 hr beforehand. Regression modeling consisted of several model-building steps and a final Tobit regression on the left-censored log 3PBA measurements. We also conducted bootstrap analyses to evaluate the stability of the regression parameters. RESULTS: Reported household pesticide use was not significantly associated with urinary 3PBA in any age group. Diet was significant for all three groups, and certain foods appeared to contribute more than others. Among adults, tobacco use was positively associated with 3PBA (p = 0.0326), and positive associations were suggested with the number of cytochrome p450-inhibiting medications taken (p = 0.0652) and minutes spent gardening (p = 0.0613) in the past month. CONCLUSIONS: Although exploratory, our findings underline the importance of collecting accurate data on household pesticide use and dietary intake when evaluating pyrethroid exposure-biomarker relationships. JF - Environmental Health Perspectives AU - Riederer, Anne M AU - Bartell, Scott M AU - Barr, Dana B AU - Ryan, P Barry PY - 2008 SP - 1015 EP - 1022 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Diets KW - Pesticides KW - Regression KW - Households KW - Health KW - Age KW - Adults KW - Regression analysis KW - Foods KW - Nutrition KW - Sampling KW - Occupation KW - Metabolites KW - Driving KW - Cytochromes KW - Gardening KW - Demographics KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743180867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Diet+and+Nondiet+Predictors+of+Urinary+3-Phenoxybenzoic+Acid+in+NHANES+1999-2002&rft.au=Riederer%2C+Anne+M%3BBartell%2C+Scott+M%3BBarr%2C+Dana+B%3BRyan%2C+P+Barry&rft.aulast=Riederer&rft.aufirst=Anne&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1015&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Design Issues in Small-Area Studies of Environment and Health AN - 743176402; 201004-31-0307836 (CE); 12110168 (EN) AB - BACKGROUND: Small-area studies are part of the tradition of spatial epidemiology, which is concerned with the analysis of geographic patterns of disease with respect to environmental, demographic, socioeconomic, and other factors. We focus on etiologic research, where the aim is to make inferences about spatially varying environmental factors influencing the risk of disease. METHODS AND RESULTS: We illustrate the approach through three exemplars: a) magnetic fields from overhead electric power lines and the occurrence of childhood leukemia, which illustrates the use of geographic information systems to focus on areas with high exposure prevalence; b) drinking-water disinfection by-products and reproductive outcomes, taking advantage of large between- to within-area variability in exposures from the water supply; and c) chronic exposure to air pollutants and cardiorespiratory health, where issues of socioeconomic confounding are particularly important. DISCUSSION: The small-area epidemiologic approach assigns exposure estimates to individuals based on location of residence or other geographic variables such as workplace or school. In this way, large populations can be studied, increasing the ability to investigate rare exposures or rare diseases. The approach is most effective when there is well-defined exposure variation across geographic units, limited within-area variation, and good control for potential confounding across areas. CONCLUSIONS: In conjunction with traditional individual-based approaches, small-area studies offer a valuable addition to the armamentarium of the environmental epidemiologist. Modeling of exposure patterns coupled with collection of individual-level data on subsamples of the population should lead to improved risk estimates (i.e., less potential for bias) and help strengthen etiologic inference. JF - Environmental Health Perspectives AU - Elliott, Paul AU - Savitz, David A PY - 2008 SP - 1098 EP - 1104 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Health KW - Epidemiology KW - Byproducts KW - Risk KW - Estimates KW - Populations KW - Etiology KW - Inference KW - Geographic information systems KW - Water supplies KW - Position (location) KW - Magnetic fields KW - Leukemias KW - Bias KW - Workplaces KW - Satellite navigation systems KW - Electric power KW - Demographics KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743176402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Design+Issues+in+Small-Area+Studies+of+Environment+and+Health&rft.au=Elliott%2C+Paul%3BSavitz%2C+David+A&rft.aulast=Elliott&rft.aufirst=Paul&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1098&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Computational Toxicology of Chloroform: Reverse Dosimetry Using Bayesian Inference, Markov Chain Monte Carlo Simulation, and Human Biomonitoring Data AN - 743135903; 201004-31-0307844 (CE); 12110176 (EN) AB - BACKGROUND: One problem of interpreting population-based biomonitoring data is the reconstruction of corresponding external exposure in cases where no such data are available. OBJECTIVES: We demonstrate the use of a computational framework that integrates physiologically based pharmacokinetic (PBPK) modeling, Bayesian inference, and Markov chain Monte Carlo simulation to obtain a population estimate of environmental chloroform source concentrations consistent with human biomonitoring data. The biomonitoring data consist of chloroform blood concentrations measured as part of the Third National Health and Nutrition Examination Survey (NHANES III), and for which no corresponding exposure data were collected. METHODS: We used a combined PBPK and shower exposure model to consider several routes and sources of exposure: ingestion of tap water, inhalation of ambient household air, and inhalation and dermal absorption while showering. We determined posterior distributions for chloroform concentration in tap water and ambient household air using U.S. Environmental Protection Agency Total Exposure Assessment Methodology (TEAM) data as prior distributions for the Bayesian analysis. RESULTS: Posterior distributions for exposure indicate that 95% of the population represented by the NHANES III data had likely chloroform exposures or = 67 microg/L in tap water and or = 0.02 microg/L in ambient household air. CONCLUSIONS: Our results demonstrate the application of computer simulation to aid in the interpretation of human biomonitoring data in the context of the exposure-health evaluation-risk assessment continuum. These results should be considered as a demonstration of the method and can be improved with the addition of more detailed data. JF - Environmental Health Perspectives AU - Lyons, Michael A AU - Yang, Raymond S H AU - Mayeno, Arthur N AU - Reisfeld, Brad PY - 2008 SP - 1040 EP - 1046 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Computer simulation KW - Chloroform KW - Monte Carlo methods KW - Tap water KW - Households KW - Health KW - Bayesian analysis KW - Human KW - Assessments KW - Inference KW - Mathematical models KW - Inhalation KW - Computation KW - Markov chains KW - Ingestion KW - Nutrition KW - Reconstruction KW - Continuums KW - Estimates KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743135903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Computational+Toxicology+of+Chloroform%3A+Reverse+Dosimetry+Using+Bayesian+Inference%2C+Markov+Chain+Monte+Carlo+Simulation%2C+and+Human+Biomonitoring+Data&rft.au=Lyons%2C+Michael+A%3BYang%2C+Raymond+S+H%3BMayeno%2C+Arthur+N%3BReisfeld%2C+Brad&rft.aulast=Lyons&rft.aufirst=Michael&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1040&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Comparison of Different Methods for Spatial Analysis of Cancer Data in Utah AN - 743133499; 201004-31-0307833 (CE); 12110165 (EN) AB - BACKGROUND: The standardized incidence ratio (SIR) and SaTScan software are used by the Environmental Epidemiology Program (EEP), Utah Department of Health, to investigate health concerns and exposures in Utah (USA). Recently, the EEP acquired the Rapid Inquiry Facility (RIF). The RIF enables access of additional dimensions of data, identifies potentially exposed populations, and computes disease rates and relative risk statistics for that potentially exposed population. OBJECTIVE: In this article we present a comparison of the SIR, SaTScan, and RIF methodologies in an investigation of cancer rates in residents living over contaminated groundwater plumes near Hill Air Force Base (HAFB) in Utah. METHODS: For this study, we used cancer data from the Utah Cancer Registry for cancers of the lung, kidney, and non-Hodgkin lymphoma. We used SIR and the RIF to investigate the cancer rate in a defined population within the study area during six consecutive 5-year time intervals (1975-2004). We used SaTScan and the RIF to explore the study area for clusters. RESULTS: The RIF risk analysis and SIR are mathematically identical. SIR is set up and computed by programming SAS; the RIF risk analysis, on the other hand, is set up through four menu-driven steps. The RIF disease-mapping feature enhanced the interpretation of SaTScan results. We found kidney and lung cancer to be statistically elevated for the potentially exposed population for one and two periods, respectively. SaTScan found two clusters, one outside the potentially exposed population and one that included a portion of that population. CONCLUSION: The RIF is an easy-to-use and useful tool that extends the ability of the investigator to conduct analysis of disease rates and interpret the findings. JF - Environmental Health Perspectives AU - Ball, Wayne AU - LeFevre, Sam AU - Jarup, Lars AU - Beale, Linda PY - 2008 SP - 1120 EP - 1124 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Cancer KW - Populations KW - Exposure KW - Health KW - Mathematical analysis KW - Risk analysis KW - Kidneys KW - Clusters KW - Lungs KW - Tools KW - Rapids KW - Statistics KW - Risk KW - Computer programs KW - Epidemiology KW - SAS KW - Intervals KW - Programming KW - Software KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743133499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Comparison+of+Different+Methods+for+Spatial+Analysis+of+Cancer+Data+in+Utah&rft.au=Ball%2C+Wayne%3BLeFevre%2C+Sam%3BJarup%2C+Lars%3BBeale%2C+Linda&rft.aulast=Ball&rft.aufirst=Wayne&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1120&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Community- and Individual-Level Socioeconomic Status and Breast Cancer Risk: Multilevel Modeling on Cape Cod, Massachusetts AN - 743129653; 201004-31-0307832 (CE); 12110164 (EN) AB - BACKGROUND: Previous research demonstrated increased risk of breast cancer associated with higher socioeconomic status (SES) measured at both the individual and community levels. However, little attention has been paid to simultaneously examining both measures. OBJECTIVES: We evaluated the independent influences of individual and community SES on the risk of breast cancer using case-control data. Because our previous work suggests that associations may be stronger after including a latency period, we also assessed the effect of community-level SES assuming a 10-year latency period. METHODS: We obtained individual education for cases and matched controls diagnosed between 1987 and 1993 on Cape Cod, Massachusetts (USA). We acquired community-level SES from census data for 1980 and 1990. Using SES data at diagnosis and 10 years earlier, we constructed models for breast cancer risk using individual-level SES only, community-level SES only, and a multilevel analysis including both. We adjusted models for other individual-level risk factors. RESULTS: Women with the highest education were at greater risk of developing breast cancer in both 1980 and 1990 [odds ratio (OR) = 1.17 and 1.19, respectively]. Similarly, women living in the highest-SES communities in 1990 had greater risk (OR = 1.30). Results were stronger in the analyses considering a latency period (OR = 1.69). Adjusting for intragroup correlation had little effect on the analyses. CONCLUSIONS: Models including individual- or community-level measures of SES produced associations similar to those observed in previous research. Results for models including both measures are consistent with a contextual effect of SES on risk of breast cancer independent of individual SES. JF - Environmental Health Perspectives AU - Webster, Thomas F AU - Hoffman, Kate AU - Weinberg, Janice AU - Vieira, Veronica AU - Aschengrau, Ann PY - 2008 SP - 1125 EP - 1129 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Cancer KW - Breast KW - Communities KW - Multilevel KW - Education KW - Health KW - Mathematical models KW - Census KW - Copyrights KW - Adjustment KW - Diagnosis KW - Correlation analysis KW - Construction KW - Control equipment KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743129653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Community-+and+Individual-Level+Socioeconomic+Status+and+Breast+Cancer+Risk%3A+Multilevel+Modeling+on+Cape+Cod%2C+Massachusetts&rft.au=Webster%2C+Thomas+F%3BHoffman%2C+Kate%3BWeinberg%2C+Janice%3BVieira%2C+Veronica%3BAschengrau%2C+Ann&rft.aulast=Webster&rft.aufirst=Thomas&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Children Are Likely to Suffer Most from Our Fossil Fuel Addiction AN - 743115062; 201004-31-0307852 (CE); 12110184 (EN) AB - BACKGROUND: The periods of fetal and child development arguably represent the stages of greatest vulnerability to the dual impacts of fossil fuel combustion: the multiple toxic effects of emitted pollutants (polycyclic aromatic hydrocarbons, particles, sulfur oxides, nitrogen oxides, metals) and the broad health impacts of global climate change attributable in large part to carbon dioxide released by fossil fuel burning. OBJECTIVES: In this commentary I highlight current scientific evidence indicating that the fetus and young child are at heightened risk of developmental impairment, asthma, and cancer from fossil fuel pollutants and from the predicted effects of climate disruption such as heat waves, flooding, infectious disease, malnutrition, and trauma. Increased risk during early development derives from the inherently greater biologic vulnerability of the developing fetus and child and from their long future lifetime, during which early insults can potentially manifest as adult as well as childhood disease. I cite recent reports concluding that reducing dependence on fossil fuel and promoting clean and sustainable energy is economically feasible. DISCUSSION: Although much has been written separately about the toxicity of fossil fuel burning emissions and the effects of climate change on health, these two faces of the problem have not been viewed together with a focus on the developing fetus and child. Adolescence and old age are also periods of vulnerability, but the potential for both immediate and long-term adverse effects is greatest when exposure occurs prenatally or in the early years. CONCLUSIONS: Consideration of the full spectrum of health risks to children from fossil fuel combustion underscores the urgent need for environmental and energy policies to reduce fossil fuel dependence and maximize the health benefits to this susceptible population. We do not have to leave our children a double legacy of ill health and ecologic disaster. JF - Environmental Health Perspectives AU - Perera, Frederica P PY - 2008 SP - 987 EP - 990 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Fossil fuels KW - Health KW - Combustion KW - Risk KW - Children KW - Climate change KW - Pollutants KW - Economics KW - Disasters KW - Toxicity KW - Asthma KW - Ecology KW - Leaves KW - Energy policy KW - Adults KW - Impairment KW - Infectious diseases KW - Nitrogen oxides KW - Toxic KW - Article KW - EE 70:Energy (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743115062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Children+Are+Likely+to+Suffer+Most+from+Our+Fossil+Fuel+Addiction&rft.au=Perera%2C+Frederica+P&rft.aulast=Perera&rft.aufirst=Frederica&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Integrating Human Health into Environmental Impact Assessment: An Unrealized Opportunity for Environmental Health and Justice AN - 743071498; 201004-31-0307851 (CE); 12110183 (EN) AB - OBJECTIVES: The National Environmental Policy Act and related state laws require many public agencies to analyze and disclose potentially significant environmental effects of agency actions, including effects on human health. In this paper we review the purpose and procedures of environmental impact assessment (EIA), existing regulatory requirements for health effects analysis, and potential barriers to and opportunities for improving integration of human health concerns within the EIA process. DATA SOURCES: We use statutes, regulations, guidelines, court opinions, and empirical research on EIA along with recent case examples of integrated health impact assessment (HIA)/EIA at both the state and federal level. DATA SYNTHESIS: We extract lessons and recommendations for integrated HIA/EIA practice from both existing practices as well as case studies. CONCLUSIONS: The case studies demonstrate the adequacy, scope, and power of existing statutory requirements for health analysis within EIA. The following support the success of integrated HIA/EIA: a proponent recognizing EIA as an available regulatory strategy for public health; the openness of the agency conducting the EIA; involvement of public health institutions; and complementary objectives among community stakeholders and health practitioners. We recommend greater collaboration among institutions responsible for EIA, public health institutions, and affected stakeholders along with guidance, resources, and training for integrated HIA/EIA practice. JF - Environmental Health Perspectives AU - Bhatia, Rajiv AU - Wernham, Aaron PY - 2008 SP - 991 EP - 1000 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 116 IS - 8 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Public health KW - Human KW - Environmental legislation KW - Environmental impact assessments KW - Laws KW - Policies KW - Assessments KW - Guidelines KW - Data sources KW - Training KW - Strategy KW - Communities KW - Conduction KW - Potential barriers KW - Synthesis KW - Copyrights KW - Empirical analysis KW - Adequacy KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743071498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Integrating+Human+Health+into+Environmental+Impact+Assessment%3A+An+Unrealized+Opportunity+for+Environmental+Health+and+Justice&rft.au=Bhatia%2C+Rajiv%3BWernham%2C+Aaron&rft.aulast=Bhatia&rft.aufirst=Rajiv&rft.date=2008-08-01&rft.volume=116&rft.issue=8&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways. AN - 71641929; 18522492 AB - Hemoglobin (Hb) released into the circulation during hemolysis and chemically modified Hb proposed for use as oxygen therapeutics exert toxic effects that are partially attributable to heme's oxidant activity. Native extracellular Hb is scavenged by haptoglobin (Hp) after alphabeta-subunit dimerization. In the absence of Hp, monocyte/macrophage cell-surface CD163 binds and clears Hb. We evaluated several chemically modified Hbs to establish the role of chemical cross-linking patterns and molecular sizes on binding and clearance by each pathway. We found that Hbs possessing beta-globin cross-linking, irrespective of polymerization, demonstrate increased Hp affinity compared with alpha-globin-stabilized Hbs. These data suggest that Hb alpha-subunit accessibility is critical for Hp binding in the absence of dimerization. beta-Globin chain cross-linked tetramers/polymers displayed strong polyvalent Hp binding with increased viscosity and formation of visible gel matrices. Modified Hb interaction with CD163 and cellular uptake demonstrated an inverse relation with molecular size, irrespective of alpha and beta cross-linking. These findings were confirmed by HO-1 induction and intracellular ferritin accumulation in CD163-expressing HEK293 cells. Based on these results, a rational and systematic approach to HBOC design may be used to optimize interaction with endogenous Hb clearance and detoxification pathways. JF - Antioxidants & redox signaling AU - Buehler, Paul W AU - Vallelian, Florence AU - Mikolajczyk, Malgorzata G AU - Schoedon, Gabriele AU - Schweizer, Thomas AU - Alayash, Abdu I AU - Schaer, Dominik J AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Rockville, Maryland, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1449 EP - 1462 VL - 10 IS - 8 KW - Antigens, CD KW - 0 KW - Antigens, Differentiation, Myelomonocytic KW - Antioxidants KW - CD163 antigen KW - Haptoglobins KW - Hemoglobins KW - Receptors, Cell Surface KW - Receptors, Scavenger KW - Globins KW - 9004-22-2 KW - Ferritins KW - 9007-73-2 KW - Index Medicus KW - Dimerization KW - Humans KW - Surface Plasmon Resonance KW - Receptors, Scavenger -- metabolism KW - Antigens, CD -- genetics KW - Antigens, Differentiation, Myelomonocytic -- genetics KW - Haptoglobins -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Protein Binding KW - Models, Biological KW - Receptors, Cell Surface -- metabolism KW - Chromatography, Gel KW - Ferritins -- metabolism KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization KW - Antigens, CD -- metabolism KW - Antigens, Differentiation, Myelomonocytic -- metabolism KW - Receptors, Cell Surface -- genetics KW - Globins -- metabolism KW - Cell Line KW - Signal Transduction -- physiology KW - Antioxidants -- metabolism KW - Hemoglobins -- metabolism KW - Hemoglobins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71641929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Structural+stabilization+in+tetrameric+or+polymeric+hemoglobin+determines+its+interaction+with+endogenous+antioxidant+scavenger+pathways.&rft.au=Buehler%2C+Paul+W%3BVallelian%2C+Florence%3BMikolajczyk%2C+Malgorzata+G%3BSchoedon%2C+Gabriele%3BSchweizer%2C+Thomas%3BAlayash%2C+Abdu+I%3BSchaer%2C+Dominik+J&rft.aulast=Buehler&rft.aufirst=Paul&rft.date=2008-08-01&rft.volume=10&rft.issue=8&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=1557-7716&rft_id=info:doi/10.1089%2Fars.2008.2028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-29 N1 - Date created - 2008-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/ars.2008.2028 ER - TY - JOUR T1 - Meth mouth. AN - 69745796; 18982966 AB - Methamphetamine (meth) is a drug traditionally sought by groups living on the fringes of society. But now, it has entered the mainstream. Over the last five years, meth has seen a surge in abuse, media coverage and attention from law-enforcement officers. Meth mouth is characterized by rampant caries, typically on the smooth surfaces of dentition. This article gives a history of meth use and abuse. It describes the condition of meth mouth and its etiology. Treatment options and other dental considerations are discussed. JF - The New York state dental journal AU - Heng, Christine K AU - Badner, Victor M AU - Schiop, Luminita Adela AD - US Public Health Service, Federal Correctional Institution, Danbury, CT, USA. cheng@bop.gov PY - 2008 SP - 50 EP - 51 VL - 74 IS - 5 SN - 0028-7571, 0028-7571 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Dentistry KW - Index Medicus KW - Humans KW - Mouth Diseases -- chemically induced KW - Mouth Diseases -- prevention & control KW - Dental Caries -- chemically induced KW - Xerostomia -- chemically induced KW - Amphetamine-Related Disorders -- complications KW - Methamphetamine -- adverse effects KW - Dental Caries -- prevention & control KW - Central Nervous System Stimulants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69745796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+York+state+dental+journal&rft.atitle=Meth+mouth.&rft.au=Heng%2C+Christine+K%3BBadner%2C+Victor+M%3BSchiop%2C+Luminita+Adela&rft.aulast=Heng&rft.aufirst=Christine&rft.date=2008-08-01&rft.volume=74&rft.issue=5&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=The+New+York+state+dental+journal&rft.issn=00287571&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-09 N1 - Date created - 2008-11-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Reprint In: Hawaii Dent J. 2009 May-Jun;40(3):15-6; quiz 21 [19743598] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cutting off the nose to save the penis. AN - 69520698; 18466268 AB - The average bicycle police officer spends 24 hours a week on his bicycle and previous studies have shown riding a bicycle with a traditional (nosed) saddle has been associated with urogenital paresthesia and sexual dysfunction. The objective of this study was to assess the effectiveness of the no-nose bicycle saddle as an ergonomic intervention and their acceptance among male bicycle police officers. Bicycle police officers from five U.S. metropolitan areas were recruited for this study. Officers completed: (i) the International Index of Erectile Function Questionnaire (IIEF); (ii) computerized pressure measurements at the points of contact on the bicycle; the handlebars, the pedals, and the saddle; (iii) one night of nocturnal Rigiscan assessment; (iv) penile vibrotactile sensitivity threshold assessed by computerized biothesiometery. Officers selected a no-nose saddle for their bicycles and were asked to use the intervention saddle exclusively for 6 months, at which point they were retested. Perineal pressure, urogenital numbness, penile vibrotactile sensitivity threshold, erectile function as measure by International Index of Erectile Function Questionnaire (IIEF) and Rigiscan. After 6 months, 90 men were reassessed. Only three men had returned to a traditional saddle. The results are presented for those who used the no-nose saddle continuously for 6 months. There was a 66% reduction in saddle contact pressure in the perineal region (P < 0.001). There was a significant improvement in penis tactile sensation (P = 0.015). There was a significant improvement in erectile function assessed by IIEF (P = 0.015). There were no changes noted in the Rigiscan measures. The number of men indicating they had not experienced urogential paresthesia while cycling for the preceding 6 months, rose from 27% to 82% using no-nose saddles. (i) With few exceptions, bicycle police officers were able to effectively use no-nose saddles in their police work. (ii) Use of no-nose saddles reduced most perineal pressure. (iii) Penile health improved after 6 month using no-nose saddles as measured by biothesiometry and IIEF. There was no improvement in Rigiscan(R) measure after 6 months of using no nose saddles, suggesting that a longer recovery time may be needed.. JF - The journal of sexual medicine AU - Schrader, Steven M AU - Breitenstein, Michael J AU - Lowe, Brian D AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. sms4@cdc.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1932 EP - 1940 VL - 5 IS - 8 KW - Index Medicus KW - Perineum KW - Paresthesia -- etiology KW - Human Engineering KW - Equipment Design KW - Humans KW - Adult KW - Paresthesia -- prevention & control KW - Pressure -- adverse effects KW - Follow-Up Studies KW - Male KW - Bicycling KW - Erectile Dysfunction -- prevention & control KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Erectile Dysfunction -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69520698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+sexual+medicine&rft.atitle=Cutting+off+the+nose+to+save+the+penis.&rft.au=Schrader%2C+Steven+M%3BBreitenstein%2C+Michael+J%3BLowe%2C+Brian+D&rft.aulast=Schrader&rft.aufirst=Steven&rft.date=2008-08-01&rft.volume=5&rft.issue=8&rft.spage=1932&rft.isbn=&rft.btitle=&rft.title=The+journal+of+sexual+medicine&rft.issn=1743-6109&rft_id=info:doi/10.1111%2Fj.1743-6109.2008.00867.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-24 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1743-6109.2008.00867.x ER - TY - JOUR T1 - Zinc diethyldithiocarbamate allergenicity: potential haptenation mechanisms. AN - 69491439; 18759874 AB - Zinc diethyldithiocarbamate (ZDEC) and its disulfide, tetraethylthiuram disulfide (TETD), are rubber accelerators and contact allergens that cross-react in some individuals. This study explored potential protein haptenation mechanisms of ZDEC and its oxidation products. ZDEC oxidation/reduction products and sites of protein binding were assessed using high-performance liquid chromatography and mass spectrometry. The murine local lymph node assay (LLNA) was employed to probe haptenation mechanisms of ZDEC by examining its allergenicity along with its oxidation products and through elimination of oxidation and chelation mechanisms by substituting cobalt for zinc [cobalt (II) dithiocarbamate, CoDEC]. Oxidation of ZDEC by hypochlorous acid (bleach, HOCl), iodine, or hydrogen peroxide resulted in production of TETD, tetraethylthiocarbamoyl disulfide, and tetraethyldicarbamoyl disulfide (TEDCD). Albumin thiols reduced TETD with subsequent mixed disulfide formation/haptenation. ZDEC directly chelated the copper ion on the active site of the superoxide dismutase, whereas CoDEC did not bind to Cu proteins or form mixed disulfides with free thiols. ZDEC, sodium diethyldithiocarbamate, TEDCD, and TETD were all positive in the LLNA except CoDEC, which was non-allergenic. The thiol is the critical functional group in ZDEC's allergenicity, and haptenation is predominantly through chelation of metalloproteins and formation of mixed disulfides. JF - Contact dermatitis AU - Chipinda, Itai AU - Hettick, Justin M AU - Simoyi, Reuben H AU - Siegel, Paul D AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA. ichipinda@cdc.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 79 EP - 89 VL - 59 IS - 2 KW - Allergens KW - 0 KW - Haptens KW - Ditiocarb KW - 99Z2744345 KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - Oxidation-Reduction KW - Cross-Sectional Studies KW - Animals KW - Mice KW - Mice, Inbred BALB C KW - Female KW - Chromatography, High Pressure Liquid KW - Ditiocarb -- chemistry KW - Disulfiram -- chemistry KW - Allergens -- chemistry KW - Haptens -- chemistry KW - Dermatitis, Allergic Contact -- etiology KW - Dermatitis, Allergic Contact -- pathology KW - Ditiocarb -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69491439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contact+dermatitis&rft.atitle=Zinc+diethyldithiocarbamate+allergenicity%3A+potential+haptenation+mechanisms.&rft.au=Chipinda%2C+Itai%3BHettick%2C+Justin+M%3BSimoyi%2C+Reuben+H%3BSiegel%2C+Paul+D&rft.aulast=Chipinda&rft.aufirst=Itai&rft.date=2008-08-01&rft.volume=59&rft.issue=2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Contact+dermatitis&rft.issn=1600-0536&rft_id=info:doi/10.1111%2Fj.1600-0536.2008.01399.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-10 N1 - Date created - 2008-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0536.2008.01399.x ER - TY - JOUR T1 - Biomarkers of neurotoxic shellfish poisoning. AN - 69463092; 18582487 AB - Urine specimens from patients diagnosed with neurotoxic shellfish poisoning (NSP) were examined for biomarkers of brevetoxin intoxication. Brevetoxins were concentrated from urine by using solid-phase extraction (SPE), and analyzed by enzyme-linked immunosorbent assay (ELISA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Urine extracts were fractionated by LC, and fractions analyzed for brevetoxins by ELISA. In subsequent LC-MS/MS analyses, several brevetoxin metabolites of B-type backbone were identified, with elution profiles consistent with those of ELISA. The more abundant brevetoxin metabolites in urine were characterized structurally by LC-MS/MS. With the exception of BTX-3, brevetoxin metabolites in urine differed from those found in shellfish and in shellfish meal remnants. Proposed structures of these major urinary metabolites are methylsulfoxy BTX-3, 27-epoxy BTX-3, and reduced BTX-B5. BTX-3 was found in all specimens examined. BTX-3 concentrations in urine, as determined by LC-MS/MS, correlated well with composite toxin measurements by ELISA (r(2)=0.96). BTX-3 is a useful biomarker for confirmation of clinical diagnosis of NSP. JF - Toxicon : official journal of the International Society on Toxinology AU - Abraham, Ann AU - Plakas, Steven M AU - Flewelling, Leanne J AU - El Said, Kathleen R AU - Jester, Edward L E AU - Granade, Hudson R AU - White, Kevin D AU - Dickey, Robert W AD - Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, P.O. Box 158, 1 Iberville Drive, Dauphin Island, AL 36528-0158, USA. ann.abraham@fda.hhs.gov Y1 - 2008/08/01/ PY - 2008 DA - 2008 Aug 01 SP - 237 EP - 245 VL - 52 IS - 2 SN - 0041-0101, 0041-0101 KW - Biomarkers KW - 0 KW - Marine Toxins KW - Neurotoxins KW - Oxocins KW - brevetoxin KW - 98225-48-0 KW - Index Medicus KW - Molecular Structure KW - Shellfish -- analysis KW - Biomarkers -- chemistry KW - Animals KW - Enzyme-Linked Immunosorbent Assay KW - Biomarkers -- urine KW - Shellfish Poisoning KW - Neurotoxins -- urine KW - Oxocins -- urine KW - Oxocins -- poisoning KW - Neurotoxins -- poisoning KW - Marine Toxins -- urine KW - Bivalvia -- metabolism KW - Oxocins -- chemistry KW - Foodborne Diseases KW - Dinoflagellida KW - Neurotoxins -- chemistry KW - Marine Toxins -- poisoning KW - Marine Toxins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69463092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Biomarkers+of+neurotoxic+shellfish+poisoning.&rft.au=Abraham%2C+Ann%3BPlakas%2C+Steven+M%3BFlewelling%2C+Leanne+J%3BEl+Said%2C+Kathleen+R%3BJester%2C+Edward+L+E%3BGranade%2C+Hudson+R%3BWhite%2C+Kevin+D%3BDickey%2C+Robert+W&rft.aulast=Abraham&rft.aufirst=Ann&rft.date=2008-08-01&rft.volume=52&rft.issue=2&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2008.04.175 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-28 N1 - Date created - 2008-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxicon.2008.04.175 ER - TY - JOUR T1 - Structural model analysis of HIV risk behaviors among sexually active minority adolescents. AN - 69455062; 18717142 AB - Contents of this article are solely the responsibility of the authors and do not necessarily reflect the opinions, official policy or position of the U.S. Department of Health and Human Services, the Substance Abuse and Mental Health Services Administration or Centers for Mental Health Services and Substance Abuse Prevention. To evaluate an HIV risk profile in sexually active black and Hispanic adolescents using a structural equation model (SEM). Grantees from 15 states and Washington, DC, were selected to participate in the study. Black and Hispanic adolescents (N = 2,371) who completed the baseline instrument were required to have experienced vaginal, oral or anal sex in order to be included in this study. Total minority youths who self-reported as black but not Hispanic were n = 1,455 and for Hispanic n = 916. The hypothesized model fit moderately well (CFI = 0.940, TLI = 0.928, RMSEA = 0.039). The key significant direct effect was found (P < 0.05) for higher alcohol, tobacco and other drug use related to nonuse of condoms, more sex partners and use of substances before sex. Current findings underscore the need to incorporate culturally sensitive strategies in developing programs for minority youth. However, given that minority group members often report greater experiences of discrimination than whites, future research in this area should also include an examination of the role of other stressors such as racial disparities and their potential cumulative impact on minority youth and their risks for alcohol, tobacco and other drug use and HIV. JF - Journal of the National Medical Association AU - Bellamy, Nikki D AU - Wang, Min Qi AU - Matthew, Resa F AU - Leitao, Marion P AU - Agee, Rená A AU - Yan, Alice F AD - Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Prevention, Traumatic Stress and Special Programs, 1 Choke Cherry Road, Room 6-1003, Rockville, MD 20857, USA. nikki.bellamy@samhsa.hhs.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 914 EP - 924 VL - 100 IS - 8 SN - 1943-4693, 1943-4693 KW - Index Medicus KW - United States KW - Educational Status KW - Humans KW - African Americans -- statistics & numerical data KW - Demography KW - Cross-Sectional Studies KW - Hispanic Americans -- statistics & numerical data KW - Risk Factors KW - Adolescent KW - Adolescent Health Services KW - Female KW - Male KW - Substance-Related Disorders -- epidemiology KW - Risk-Taking KW - Minority Groups -- statistics & numerical data KW - HIV Infections -- epidemiology KW - Sexual Behavior -- statistics & numerical data KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69455062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Medical+Association&rft.atitle=Structural+model+analysis+of+HIV+risk+behaviors+among+sexually+active+minority+adolescents.&rft.au=Bellamy%2C+Nikki+D%3BWang%2C+Min+Qi%3BMatthew%2C+Resa+F%3BLeitao%2C+Marion+P%3BAgee%2C+Ren%C3%A1+A%3BYan%2C+Alice+F&rft.aulast=Bellamy&rft.aufirst=Nikki&rft.date=2008-08-01&rft.volume=100&rft.issue=8&rft.spage=914&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Medical+Association&rft.issn=19434693&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-19 N1 - Date created - 2008-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Food microbial pathogen detection and analysis using DNA microarray technologies. AN - 69444966; 18673074 AB - Culture-based methods used for microbial detection and identification are simple to use, relatively inexpensive, and sensitive. However, culture-based methods are too time-consuming for high-throughput testing and too tedious for analysis of samples with multiple organisms and provide little clinical information regarding the pathogen (e.g., antibiotic resistance genes, virulence factors, or strain subtype). DNA-based methods, such as polymerase chain reaction (PCR), overcome some these limitations since they are generally faster and can provide more information than culture-based methods. One limitation of traditional PCR-based methods is that they are normally limited to the analysis of a single pathogen, a small group of related pathogens, or a small number of relevant genes. Microarray technology enables a significant expansion of the capability of DNA-based methods in terms of the number of DNA sequences that can be analyzed simultaneously, enabling molecular identification and characterization of multiple pathogens and many genes in a single array assay. Microarray analysis of microbial pathogens has potential uses in research, food safety, medical, agricultural, regulatory, public health, and industrial settings. In this article, we describe the main technical elements of microarray technology and the application and potential use of DNA microarrays for food microbial analysis. JF - Foodborne pathogens and disease AU - Rasooly, Avraham AU - Herold, Keith E AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryland, USA. rasoolya@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 531 EP - 550 VL - 5 IS - 4 KW - DNA Probes KW - 0 KW - DNA, Bacterial KW - RNA, Bacterial KW - RNA, Ribosomal KW - Virulence Factors KW - Index Medicus KW - Sensitivity and Specificity KW - Genotype KW - Gene Expression Profiling KW - DNA, Bacterial -- genetics KW - Polymerase Chain Reaction -- methods KW - Drug Resistance, Bacterial -- genetics KW - RNA, Ribosomal -- genetics KW - Virulence Factors -- genetics KW - RNA, Bacterial -- genetics KW - Microspheres KW - Bacteria -- genetics KW - Food Microbiology KW - Oligonucleotide Array Sequence Analysis -- methods KW - Bacteria -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69444966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Foodborne+pathogens+and+disease&rft.atitle=Food+microbial+pathogen+detection+and+analysis+using+DNA+microarray+technologies.&rft.au=Rasooly%2C+Avraham%3BHerold%2C+Keith+E&rft.aulast=Rasooly&rft.aufirst=Avraham&rft.date=2008-08-01&rft.volume=5&rft.issue=4&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Foodborne+pathogens+and+disease&rft.issn=1556-7125&rft_id=info:doi/10.1089%2Ffpd.2008.0119 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-23 N1 - Date created - 2008-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Microbiol Methods. 2005 Mar;60(3):291-8 [15649531] Appl Environ Microbiol. 2005 Mar;71(3):1373-86 [15746340] Mol Cell Probes. 2005 Jun;19(3):195-201 [15797820] Surg Today. 2005;35(5):396-403 [15864422] J Clin Microbiol. 2005 May;43(5):2291-302 [15872258] Anal Chem. 2005 Aug 1;77(15):5041-7 [16053320] Biosens Bioelectron. 2005 Sep 15;21(3):500-7 [16076440] J Clin Microbiol. 2005 Aug;43(8):4197-9 [16081976] J Clin Microbiol. 2005 Sep;43(9):4507-14 [16145099] Philos Trans R Soc Lond B Biol Sci. 2005 Oct 29;360(1462):1897-903 [16214747] Methods. 2005 Sep;37(1):103-13 [16199178] J Microbiol Methods. 2005 Dec;63(3):318-30 [15923050] Clin Biochem. 2006 Jan;39(1):67-73 [16330012] J Clin Microbiol. 2006 Jan;44(1):244-50 [16390982] J Clin Microbiol. 2006 Feb;44(2):504-12 [16455905] J Microbiol Methods. 2006 Jun;65(3):453-67 [16239042] J Microbiol Methods. 2006 Jun;65(3):488-502 [16242802] J AOAC Int. 2006 May-Jun;89(3):873-83 [16792089] J Virol Methods. 2006 Sep;136(1-2):17-23 [16690139] J Med Microbiol. 2006 Sep;55(Pt 9):1197-209 [16914649] J Clin Microbiol. 2006 Sep;44(9):3167-71 [16954243] J Appl Microbiol. 2006 Oct;101(4):754-63 [16968287] J Biomol Screen. 2006 Oct;11(7):773-81 [16943392] J Clin Microbiol. 2006 Dec;44(12):4376-83 [17021058] Anal Biochem. 2007 Jan 1;360(1):169-71 [16996468] Anal Biochem. 2007 Jan 15;360(2):244-54 [17123456] Anal Biochem. 2007 Feb 15;361(2):244-52 [17184721] J Biomed Opt. 2007 Jan-Feb;12(1):014038 [17343513] Mol Cell Probes. 2007 Jun;21(3):161-70 [17123780] Mar Pollut Bull. 2007 May;54(5):521-36 [17350051] Int J Food Microbiol. 2007 Jun 30;117(2):131-40 [17512074] Appl Microbiol Biotechnol. 2007 Aug;76(1):225-33 [17492283] Appl Environ Microbiol. 2007 Oct;73(20):6566-76 [17827305] Nucleic Acids Res. 2003 Jun 15;31(12):e67 [12799456] Biotechnol Bioeng. 2003 Sep 20;83(6):721-8 [12889036] J Clin Microbiol. 2000 Feb;38(2):781-8 [10655385] Biotechniques. 2000 Sep;29(3):630-5 [10997277] Appl Environ Microbiol. 2001 Jul;67(7):3258-63 [11425749] Int J Food Microbiol. 2001 Jul 20;67(1-2):71-80 [11482571] J Mol Med (Berl). 2001 Jun;79(5-6):329-32 [11485028] Nucleic Acids Res. 2001 Aug 15;29(16):E81 [11504889] Microbiol Immunol. 2004;48(2):91-6 [14978333] Int J Food 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Environ Microbiol. 2004 Jul;70(7):4256-66 [15240309] Diagn Microbiol Infect Dis. 2004 Jul;49(3):163-71 [15246505] J Mol Microbiol Biotechnol. 2008;14(1-3):6-15 [17957105] J Clin Microbiol. 2007 Nov;45(11):3514-21 [17728472] Jpn J Infect Dis. 2007 Nov;60(6):355-61 [18032834] Anal Chem. 2007 Dec 1;79(23):9007-13 [17949012] Microb Drug Resist. 2007 Winter;13(4):281-8 [18184054] Biomacromolecules. 2008 Jan;9(1):355-62 [18052028] Microbiology. 2008 Feb;154(Pt 2):462-75 [18227250] Mol Cell Probes. 2003 Aug;17(4):187-96 [12944122] J Clin Microbiol. 2003 Sep;41(9):4071-80 [12958228] J Appl Microbiol. 2003;95(4):787-98 [12969293] Antimicrob Agents Chemother. 2003 Oct;47(10):3290-5 [14506043] Biotechniques. 2003 Dec;35(6):1216-21 [14682056] J Mol Diagn. 2004 Aug;6(3):236-42 [15269301] Biotechniques. 2004 Jul;37(1):40, 42, 44 [15283198] J Antimicrob Chemother. 2004 Aug;54(2):376-85 [15201233] J Clin Microbiol. 2004 Aug;42(8):3766-74 [15297528] Annu Rev Microbiol. 1986;40:337-65 [2430518] FEMS Microbiol Rev. 1994 Oct;15(2-3):155-73 [7524576] Nucleic Acids Res. 1996 Aug 1;24(15):3040-7 [8760891] Appl Environ Microbiol. 1997 Jun;63(6):2397-402 [9172361] Anal Biochem. 1997 Aug 1;250(2):203-11 [9245440] Anal Biochem. 1997 Sep 5;251(2):270-9 [9299026] J Mol Evol. 1998 Jun;46(6):716-20 [9608054] J Mol Evol. 1998 Nov;47(5):565-77 [9797407] Anal Biochem. 1999 Jan 1;266(1):23-30 [9887210] Nucleic Acids Res. 1999 May 1;27(9):1970-7 [10198429] Cancer Res. 2004 Nov 1;64(21):7664-7 [15520165] Biosens Bioelectron. 2004 Nov 1;20(4):684-98 [15522583] FEMS Microbiol Lett. 2004 Nov 15;240(2):215-23 [15522510] Appl Environ Microbiol. 2004 Dec;70(12):7436-44 [15574946] FEMS Microbiol Lett. 2005 Jan 1;242(1):65-71 [15621421] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/fpd.2008.0119 ER - TY - JOUR T1 - Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists. AN - 69433269; 18708391 AB - Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P(interaction) = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Bhatti, Parveen AU - Doody, Michele M AU - Alexander, Bruce H AU - Yuenger, Jeff AU - Simon, Steven L AU - Weinstock, Robert M AU - Rosenstein, Marvin AU - Stovall, Marilyn AU - Abend, Michael AU - Preston, Dale L AU - Pharoah, Paul AU - Struewing, Jeffery P AU - Sigurdson, Alice J AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892-7238, USA. bhattip@mail.NIH.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 2007 EP - 2011 VL - 17 IS - 8 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - United States KW - Genotype KW - Humans KW - Chi-Square Distribution KW - Case-Control Studies KW - Incidence KW - Middle Aged KW - Likelihood Functions KW - Male KW - Female KW - Breast Neoplasms -- genetics KW - Polymorphism, Single Nucleotide KW - Breast Neoplasms -- mortality KW - Breast Neoplasms -- etiology KW - Occupational Exposure -- adverse effects KW - Neoplasms, Radiation-Induced -- mortality KW - Neoplasms, Radiation-Induced -- genetics KW - Radiation, Ionizing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69433269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Breast+cancer+risk+polymorphisms+and+interaction+with+ionizing+radiation+among+U.S.+radiologic+technologists.&rft.au=Bhatti%2C+Parveen%3BDoody%2C+Michele+M%3BAlexander%2C+Bruce+H%3BYuenger%2C+Jeff%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BRosenstein%2C+Marvin%3BStovall%2C+Marilyn%3BAbend%2C+Michael%3BPreston%2C+Dale+L%3BPharoah%2C+Paul%3BStruewing%2C+Jeffery+P%3BSigurdson%2C+Alice+J&rft.aulast=Bhatti&rft.aufirst=Parveen&rft.date=2008-08-01&rft.volume=17&rft.issue=8&rft.spage=2007&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0300 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-16 N1 - Date created - 2008-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 2006 Jun 15;106(12):2707-15 [16639729] Cytogenet Genome Res. 2006;113(1-4):188-93 [16575179] Radiat Res. 2007 Jun;167(6):727-34 [17523852] Nature. 2007 Jun 28;447(7148):1087-93 [17529967] Nat Genet. 2007 Aug;39(8):954-6 [17618282] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2000-7 [17932347] Int J Cancer. 2008 Jan 1;122(1):177-82 [17764108] Endocr Relat Cancer. 2001 Sep;8(3):197-209 [11566611] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Oncogene. 2003 Sep 1;22(37):5848-54 [12947391] Mol Carcinog. 2004 Sep;41(1):1-16 [15352122] J Chronic Dis. 1987;40 Suppl 2:45S-57S [3312274] JAMA. 1991 Mar 13;265(10):1290-4 [2053936] Breast Cancer Res. 2005;7(1):21-32 [15642178] Biochem Biophys Res Commun. 2006 Feb 3;340(1):83-9 [16359639] Radiat Res. 2006 Jul;166(1 Pt 2):174-92 [16808606] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0300 ER - TY - JOUR T1 - Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms. AN - 69431595; 18566013 AB - This study investigated associations between occupational pesticide exposure and renal cell carcinoma (RCC) risk. To follow-up on a previous report by Buzio et al., we also considered whether this association could be modified by glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) genotypes. About 1097 RCC cases and 1476 controls from Central and Eastern Europe were interviewed to collect data on lifetime occupational histories. Occupational information for jobs held for at least 12 months duration was coded for pesticide exposures and assessed for frequency and intensity of exposure. GSTM1 and GSTT1 gene deletions were analyzed using TaqMan assays. A significant increase in RCC risk was observed among subjects ever exposed to pesticides [odds ratio (OR): 1.60; 95% confidence interval (CI): 1.00-2.55]. After stratification by genotypes, increased risk was observed among exposed subjects with at least one GSTM1 active allele (OR: 4.00; 95% CI: 1.55-10.33) but not among exposed subjects with two GSTM1 inactive alleles compared with unexposed subjects with two inactive alleles (P-interaction: 0.04). Risk was highest among exposed subjects with both GSTM1 and GSTT1 active genotypes (OR: 6.47; 95% CI: 1.82-23.00; P-interaction: 0.02) compared with unexposed subjects with at least one GSTM1 or T1 inactive genotype. In the largest RCC case-control study with genotype information conducted to date, we observed that risk associated with pesticide exposure was exclusive to individuals with active GSTM1/T1 genotypes. These findings further support the hypothesis that glutathione S-transferase polymorphisms can modify RCC risk associated with occupational pesticide exposure. JF - Carcinogenesis AU - Karami, S AU - Boffetta, P AU - Rothman, N AU - Hung, R J AU - Stewart, T AU - Zaridze, D AU - Navritalova, M AU - Mates, D AU - Janout, V AU - Kollarova, H AU - Bencko, V AU - Szeszenia-Dabrowska, N AU - Holcatova, I AU - Mukeria, A AU - Gromiec, J AU - Chanock, S J AU - Brennan, P AU - Chow, W-H AU - Moore, L E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. karamis@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1567 EP - 1571 VL - 29 IS - 8 KW - Pesticides KW - 0 KW - GSTT2 protein, human KW - EC 2.5.1.- KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Occupational Exposure KW - Humans KW - Aged KW - Europe -- epidemiology KW - Risk Assessment KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Interviews as Topic KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Male KW - Kidney Neoplasms -- genetics KW - Carcinoma, Renal Cell -- enzymology KW - Carcinoma, Renal Cell -- classification KW - Polymorphism, Genetic KW - Kidney Neoplasms -- enzymology KW - Kidney Neoplasms -- chemically induced KW - Kidney Neoplasms -- epidemiology KW - Glutathione Transferase -- genetics KW - Carcinoma, Renal Cell -- genetics KW - Pesticides -- toxicity KW - Carcinoma, Renal Cell -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69431595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Renal+cell+carcinoma%2C+occupational+pesticide+exposure+and+modification+by+glutathione+S-transferase+polymorphisms.&rft.au=Karami%2C+S%3BBoffetta%2C+P%3BRothman%2C+N%3BHung%2C+R+J%3BStewart%2C+T%3BZaridze%2C+D%3BNavritalova%2C+M%3BMates%2C+D%3BJanout%2C+V%3BKollarova%2C+H%3BBencko%2C+V%3BSzeszenia-Dabrowska%2C+N%3BHolcatova%2C+I%3BMukeria%2C+A%3BGromiec%2C+J%3BChanock%2C+S+J%3BBrennan%2C+P%3BChow%2C+W-H%3BMoore%2C+L+E&rft.aulast=Karami&rft.aufirst=S&rft.date=2008-08-01&rft.volume=29&rft.issue=8&rft.spage=1567&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-04 N1 - Date created - 2008-08-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):449-54 [10794492] Am J Epidemiol. 2008 Apr 1;167(7):759-74 [18270371] Pharmacogenetics. 2001 Aug;11(6):521-35 [11505222] Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1239-48 [11751440] Occup Med (Lond). 2002 May;52(3):157-64 [12063361] Med Lav. 2002 Jul-Aug;93(4):303-9 [12212398] Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):885-9 [12223433] Epidemiology. 2003 Sep;14(5):585-92 [14501274] Occup Environ Med. 2003 Oct;60(10):789-93 [14504370] Chem Biol Interact. 1986 Oct 15;60(1):31-45 [3536138] Toxicol Appl Pharmacol. 1991 Jan;107(1):54-62 [1987660] Scand J Work Environ Health. 1994 Jun;20(3):160-5 [7973487] Int J Cancer. 1995 May 29;61(5):601-5 [7768630] Int J Epidemiol. 1995 Feb;24(1):51-7 [7797356] Arch Toxicol. 1997;71(9):596-9 [9285043] Am J Epidemiol. 1998 Sep 1;148(5):424-30 [9737554] Cancer Res. 1999 Jun 15;59(12):2903-8 [10383153] Int J Cancer. 2005 Mar 10;114(1):101-8 [15523697] Rev Environ Health. 2005 Apr-Jun;20(2):103-18 [16121833] Int J Cancer. 2006 May 15;118(10):2543-7 [16353144] Am J Epidemiol. 2006 Dec 1;164(11):1027-42 [17000715] Carcinogenesis. 2007 Sep;28(9):1960-4 [17617661] Chem Biol Interact. 2000 Dec 1;129(1-2):61-76 [11154735] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn153 ER - TY - JOUR T1 - Population monitoring for acute exposure to 210Po. AN - 69420085; 18695450 AB - To investigate the feasibility of using single void urine samples to monitor internal radiation exposure of first responders and large populations int he event of a radiological incident involving the intentional dispersal of 210Po. Urinary excretion of 210Po was evaluated and organ absorbed and effective doses were calculated subsequent to an acute unit intake of 210Po. 210Po can be detected in single void urine samples at levels sufficient to detect effective dose below recommended limits. Minimum intakes of 210Po that would result in clinically significant effects were estimated. Collection and analysis of single void urine samples is adequate to identify persons who may be exposed in the event of a radiological emergency involving 210Po. Also, the first responder limit appears to be sufficiently protective to prevent clinically significant deterministic effects. JF - Journal of occupational and environmental medicine AU - Anderson, Jeri L AU - Spitz, Henry B AU - Daniels, Robert D AD - Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio 45226, USA. JLAnderson@cdc.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 916 EP - 923 VL - 50 IS - 8 KW - Radioisotopes KW - 0 KW - Polonium KW - DQY03U61EJ KW - Index Medicus KW - Radiation Monitoring -- methods KW - Humans KW - Environmental Exposure -- analysis KW - Monte Carlo Method KW - Radioisotopes -- metabolism KW - Polonium -- urine KW - Polonium -- metabolism KW - Radioisotopes -- urine KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69420085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Population+monitoring+for+acute+exposure+to+210Po.&rft.au=Anderson%2C+Jeri+L%3BSpitz%2C+Henry+B%3BDaniels%2C+Robert+D&rft.aulast=Anderson&rft.aufirst=Jeri&rft.date=2008-08-01&rft.volume=50&rft.issue=8&rft.spage=916&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=1536-5948&rft_id=info:doi/10.1097%2FJOM.0b013e318181b4f2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JOM.0b013e318181b4f2 ER - TY - JOUR T1 - Summary of roundtable discussion on vitamin D research needs. AN - 69409213; 18689407 AB - We summarize the discussions of a roundtable following the conference "Vitamin D and Health in the 21st Century: an Update." The roundtable participants offered additional information on vitamin D research needs from a critical, impartial, and interdisciplinary perspective. Although the group recognized the progress to date, they found that the available evidence on the relation of 25-hydroxyvitamin D, dietary intake, status, functional health, and adverse outcomes has significant limitations because most studies have been short term, have failed to consider important confounders such as baseline vitamin D status and body mass index, and did not study key populations. To meet these data gaps, the roundtable identified several overarching research needs: 1) long-term, high-quality dose-response studies with relevant outcomes, including bone health, other functional outcomes (such as immune function, autoimmune disorders, and chronic disease prevention), and adverse outcomes (such as hypercalcemia and hypercalcuria), especially in understudied population groups such as dark-skinned individuals, infants, adolescents, reproductive-aged women, and pregnant and lactating women; 2) further research to understand the relation of 25-hydroxyvitamin D threshold values to relevant functional outcomes in each life stage and in racial and ethnic groups; 3) further research to understand the metabolic partitioning, fate, and mobilization of key vitamin D metabolites at recommended and greater than recommended intakes to assess the availability of stored vitamin D, relative contributions of endogenously produced and dietary vitamin D, and impact of important confounders (such as body mass index) on vitamin D status; and 4) further research to define the maximal, long-term vitamin D intake to ensure safety for all humans. JF - The American journal of clinical nutrition AU - Brannon, Patsy M AU - Yetley, Elizabeth A AU - Bailey, Regan L AU - Picciano, Mary Frances AD - Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 587S EP - 592S VL - 88 IS - 2 KW - Vitamin D KW - 1406-16-2 KW - Abridged Index Medicus KW - Index Medicus KW - Nutritional Status KW - Ethnic Groups KW - Dose-Response Relationship, Drug KW - Humans KW - Body Mass Index KW - Nutritional Requirements KW - Biomedical Research -- organization & administration KW - Vitamin D -- physiology KW - Nutrition Policy KW - Vitamin D -- adverse effects KW - Vitamin D -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69409213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Summary+of+roundtable+discussion+on+vitamin+D+research+needs.&rft.au=Brannon%2C+Patsy+M%3BYetley%2C+Elizabeth+A%3BBailey%2C+Regan+L%3BPicciano%2C+Mary+Frances&rft.aulast=Brannon&rft.aufirst=Patsy&rft.date=2008-08-01&rft.volume=88&rft.issue=2&rft.spage=587S&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=1938-3207&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-12 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products: hepatotoxicity of deoxynivalenol. AN - 69357079; 18300328 AB - Deoxynivalenol (DON) is a mycotoxin food contaminant found in several cereal grains. The literature on the liver toxicity of DON in vivo is conflicting and does not clearly characterize its hepatotoxic effects. Cultured rat liver clone-9 cells were used as a model to assess the hepatotoxic potential of DON. The cell cultures, seeded onto 96-well plates, were treated at confluence with varying concentrations of DON (0-100 microg ml(-1)) for 48 h at 37 degrees C in 5% CO2. After the treatment period, the cells were assayed for a number of hepatotoxic endpoints that included cytotoxicity, double-stranded DNA (ds-DNA) content, oxidative stress and mitochondrial function. The concentration-dependent toxicity of DON, as measured by cytotoxicity and ds-DNA content, was observed over the entire concentration range studied beginning at 0.5 microg ml(-1). DON also induced a significant concentration-dependent increase in oxidative stress at DON concentrations starting at 10 microg ml(-1). The mitochondrial function of the treated cells decreased with the increasing concentration of DON exposure, but it was not statistically different from that of the control value. Liver histopathology observed at 3, 24 and 72 h following a single intraperitoneal administration dose of DON (10 mg kg(-1) BW) to adult male rats is consistent with early mild hepatotoxicity. The overall results of this study suggest that acute DON exposure has early mild cytotoxic effects on hepatocytes in vivo that are expressed as severe effects in rat liver clone-9 cells in vitro. JF - Journal of applied toxicology : JAT AU - Sahu, Saura C AU - Garthoff, Larry H AU - Robl, Martin G AU - Chirtel, Stuart J AU - Ruggles, Dennis I AU - Flynn, Thomas J AU - Sobotka, Thomas J AD - Division of Toxicology, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD 20708, USA. saura.sahu@fda.hhs.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 765 EP - 772 VL - 28 IS - 6 SN - 0260-437X, 0260-437X KW - Trichothecenes KW - 0 KW - DNA KW - 9007-49-2 KW - deoxynivalenol KW - JT37HYP23V KW - Index Medicus KW - Rats KW - Clone Cells KW - Animals KW - Rats, Sprague-Dawley KW - Cell Survival -- drug effects KW - Cells, Cultured KW - DNA -- genetics KW - Oxidative Stress -- drug effects KW - Mitochondria, Liver -- drug effects KW - DNA -- biosynthesis KW - Male KW - Cell Line KW - Trichothecenes -- toxicity KW - Hepatocytes -- drug effects KW - Chemical and Drug Induced Liver Injury -- pathology KW - Food Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69357079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Rat+liver+clone-9+cells+in+culture+as+a+model+for+screening+hepatotoxic+potential+of+food-related+products%3A+hepatotoxicity+of+deoxynivalenol.&rft.au=Sahu%2C+Saura+C%3BGarthoff%2C+Larry+H%3BRobl%2C+Martin+G%3BChirtel%2C+Stuart+J%3BRuggles%2C+Dennis+I%3BFlynn%2C+Thomas+J%3BSobotka%2C+Thomas+J&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2008-08-01&rft.volume=28&rft.issue=6&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.1337 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-14 N1 - Date created - 2008-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jat.1337 ER - TY - JOUR T1 - Cutting a battery pack cable can start a fire. AN - 69342243; 18648273 JF - Nursing AU - Mirsaidi, Nasrin AD - Center for Devices and Radiological Health. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 13 EP - 14 VL - 38 IS - 8 KW - Medical Waste Disposal KW - 0 KW - Nursing KW - United States KW - United States Food and Drug Administration KW - Humans KW - Therapeutic Irrigation -- instrumentation KW - Equipment Safety KW - Operating Room Nursing KW - Disposable Equipment KW - Debridement -- instrumentation KW - Medical Waste Disposal -- methods KW - Equipment Failure KW - Explosions -- prevention & control KW - Electric Power Supplies -- adverse effects KW - Safety Management -- organization & administration KW - Fires -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69342243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing&rft.atitle=Cutting+a+battery+pack+cable+can+start+a+fire.&rft.au=Mirsaidi%2C+Nasrin&rft.aulast=Mirsaidi&rft.aufirst=Nasrin&rft.date=2008-08-01&rft.volume=38&rft.issue=8&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Nursing&rft.issn=1538-8689&rft_id=info:doi/10.1097%2F01.NURSE.0000327465.69676.1c LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.NURSE.0000327465.69676.1c ER - TY - JOUR T1 - Current regulatory toxicology perspectives on the development of herbal medicines to prescription drug products in the United States. AN - 69329036; 18614266 AB - Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. The US food and drug administration (FDA) published a guidance to assist academic and industry sponsors in the development of this unique group of drug products, and has recently approved an new drug application (NDA) based on green tea extract (Veregen) for topical treatment of genital and perianal warts. In this article, current regulatory views on issues related to requirements and recommendations on various types of nonclinical toxicity studies in support of clinical trials and filing an NDA for a herbal medicine, including pharm/tox aspects of green tea extract (Veregen) NDA, are discussed. Topics include nonclinical pharmacology/toxicology perspectives on herbal nomenclature and its identification, previous human experience and initial clinical trial proposal, regulatory aspects of acute toxicity studies, chronic toxicity studies, mutagenicity studies, reproductive toxicity studies, and carcinogenicity studies on botanicals. Certain regulatory review-related issues are also presented. It is anticipated that through a proactive two-way communication between the Agency and the sponsor, toxicological development of botanical drug product can be significantly facilitated. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Wu, Kuei-Meng AU - Ghantous, Hanan AU - Birnkrant, Debra B AD - Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States. kueimeng.wu@fda.hhs.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 2606 EP - 2610 VL - 46 IS - 8 SN - 0278-6915, 0278-6915 KW - Teratogens KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Mutagenicity Tests KW - Humans KW - Toxicity Tests KW - Carcinogenicity Tests KW - Teratogens -- toxicity KW - Terminology as Topic KW - Drug Prescriptions KW - Plants, Medicinal -- toxicity KW - Legislation, Drug -- trends KW - Herbal Medicine -- legislation & jurisprudence KW - Plants, Medicinal -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69329036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Current+regulatory+toxicology+perspectives+on+the+development+of+herbal+medicines+to+prescription+drug+products+in+the+United+States.&rft.au=Wu%2C+Kuei-Meng%3BGhantous%2C+Hanan%3BBirnkrant%2C+Debra+B&rft.aulast=Wu&rft.aufirst=Kuei-Meng&rft.date=2008-08-01&rft.volume=46&rft.issue=8&rft.spage=2606&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2008.05.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-15 N1 - Date created - 2008-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2008.05.029 ER - TY - JOUR T1 - Evaluation of the butter flavoring chemical diacetyl and a fluorochemical paper additive for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. AN - 69326905; 18585428 AB - Diacetyl (2,3-butanedione) is a yellowish liquid that is usually mixed with other ingredients to produce butter flavor or other flavors in a variety of food products. Inhalation of butter flavoring vapors was first associated with clinical bronchiolitis obliterans among workers in microwave popcorn production. Recent findings have shown irreversible obstructive lung disease among workers not only in the microwave popcorn industry, but also in flavoring manufacture, and in chemical synthesis of diacetyl, a predominant chemical for butter flavoring. It has been reported that perfluorochemicals utilized in food packaging are migrating into foods and may be sources of oral exposure. Relatively small quantities of perfluorochemicals are used in the manufacturing of paper or paperboard that is in direct contact with food to repel oil or grease and water. Because of recent concerns about perfluorochemicals such as those found on microwave popcorn bags (e.g. Lodyne P208E) and diacetyl in foods, we evaluated both compounds for mutagenicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. Lodyne P208E was less toxic than diacetyl and did not induce a mutagenic response. Diacetyl induced a highly mutagenic response in the L5178Y mouse lymphoma mutation assay in the presence of human liver S9 for activation. The increase in the frequency of small colonies in the assay with diacetyl indicates that diacetyl causes damage to multiple loci on chromosome 11 in addition to functional loss of the thymidine kinase locus. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Whittaker, Paul AU - Clarke, Jane J AU - San, Richard H C AU - Begley, Timothy H AU - Dunkel, Virginia C AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, United States. paul.whittaker@fda.hhs.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 2928 EP - 2933 VL - 46 IS - 8 SN - 0278-6915, 0278-6915 KW - Chlorofluorocarbons, Methane KW - 0 KW - Flavoring Agents KW - Hydrocarbons, Fluorinated KW - Lodyne P208E KW - Mutagens KW - Butter KW - 8029-34-3 KW - Diacetyl KW - K324J5K4HM KW - Index Medicus KW - Paper KW - Translocation, Genetic -- drug effects KW - Animals KW - Chromosome Deletion KW - Aneuploidy KW - Humans KW - Liver -- metabolism KW - Cell Line, Tumor KW - Mice KW - Leukemia L5178 KW - Mutagenicity Tests KW - Point Mutation -- drug effects KW - Liver -- drug effects KW - Mitosis -- drug effects KW - Colony-Forming Units Assay KW - Flavoring Agents -- toxicity KW - Diacetyl -- toxicity KW - Chlorofluorocarbons, Methane -- toxicity KW - Hydrocarbons, Fluorinated -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69326905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Evaluation+of+the+butter+flavoring+chemical+diacetyl+and+a+fluorochemical+paper+additive+for+mutagenicity+and+toxicity+using+the+mammalian+cell+gene+mutation+assay+in+L5178Y+mouse+lymphoma+cells.&rft.au=Whittaker%2C+Paul%3BClarke%2C+Jane+J%3BSan%2C+Richard+H+C%3BBegley%2C+Timothy+H%3BDunkel%2C+Virginia+C&rft.aulast=Whittaker&rft.aufirst=Paul&rft.date=2008-08-01&rft.volume=46&rft.issue=8&rft.spage=2928&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2008.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-15 N1 - Date created - 2008-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2008.06.001 ER - TY - JOUR T1 - Simulated solar light-induced p53 mutagenesis in SKH-1 mouse skin: a dose-response assessment. AN - 69325874; 18314877 AB - Sunlight and ultraviolet-induced mutation of the p53 gene is a frequent, possibly obligate step in skin cancer development, making quantitative measurement of p53 mutation an ideal biomarker for sunlight-induced skin carcinogenesis. To understand how the appearance of p53 mutation relates to skin tumor development, SKH-1 hairless mice were exposed 5 d per week to one of four different doses of simulated solar light (SSL; 0, 6.85, 13.70, 20.55 mJ x CIE/cm(2)) previously characterized for their tumorigenic potential. Allele-specific competitive blocker-PCR (ACB-PCR) was used to measure levels of p53 codon 270 CGT to TGT mutation within DNA isolated from dorsal skin of exposed mice. For each dose, p53 mutant fraction (MF) was measured after 4, 16, and 28 wk of exposure. Significant dose- and time-dependent increases in p53 MF were identified. All p53 MF measurements were integrated by relating the observed p53 MF to the cumulative dose of SSL. The increase in the logarithm of p53 MF was described by the linear function: log(10) MF = alpha + 0.0016 x d, where alpha is the spontaneous log(10) MF after a particular time point and d is the dose of SSL in mJ x CIE/cm(2). The p53 MF induced in nontumor bearing skin by 28 wk of exposure at the high dose of SSL was significantly lower than that found in skin tumors induced by approximately 32 wk of exposure to the same dose of SSL. p53 MF showed a strong negative correlation with tumor latency, suggesting this quantitative biomarker has the potential to predict tumorigenicity. (c) 2008 Wiley-Liss, Inc. JF - Molecular carcinogenesis AU - Verkler, Tracie L AU - Delongchamp, Robert R AU - Miller, Barbara J AU - Webb, Peggy J AU - Howard, Paul C AU - Parsons, Barbara L AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research (NCTR), USFDA, Jefferson, Arkansas 72079, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 599 EP - 607 VL - 47 IS - 8 KW - Biomarkers, Tumor KW - 0 KW - Index Medicus KW - Polymerase Chain Reaction KW - Animals KW - Ultraviolet Rays KW - Alleles KW - Electrophoresis, Polyacrylamide Gel KW - Dose-Response Relationship, Drug KW - Neoplasms, Radiation-Induced KW - Sunlight KW - Mice KW - Mutation KW - Skin -- drug effects KW - Genes, p53 KW - Skin Neoplasms -- chemically induced KW - Skin -- metabolism KW - Skin -- pathology KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69325874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Simulated+solar+light-induced+p53+mutagenesis+in+SKH-1+mouse+skin%3A+a+dose-response+assessment.&rft.au=Verkler%2C+Tracie+L%3BDelongchamp%2C+Robert+R%3BMiller%2C+Barbara+J%3BWebb%2C+Peggy+J%3BHoward%2C+Paul+C%3BParsons%2C+Barbara+L&rft.aulast=Verkler&rft.aufirst=Tracie&rft.date=2008-08-01&rft.volume=47&rft.issue=8&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.20415 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-14 N1 - Date created - 2008-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20415 ER - TY - JOUR T1 - Relative quantitative comparisons of the extracellular protein profiles of Staphylococcus aureus UAMS-1 and its sarA, agr, and sarA agr regulatory mutants using one-dimensional polyacrylamide gel electrophoresis and nanocapillary liquid chromatography coupled with tandem mass spectrometry. AN - 69323063; 18539737 AB - One-dimensional polyacrylamide gel electrophoresis followed by nanocapillary liquid chromatography coupled with mass spectrometry was used to analyze proteins isolated from Staphylococcus aureus UAMS-1 after 3, 6, 12, and 24 h of in vitro growth. Protein abundance was determined using a quantitative value termed normalized peptide number, and overall, proteins known to be associated with the cell wall were more abundant early on in growth, while proteins known to be secreted into the surrounding milieu were more abundant late in growth. In addition, proteins from spent media and cell lysates of strain UAMS-1 and its isogenic sarA, agr, and sarA agr regulatory mutant strains during exponential growth were identified, and their relative abundances were compared. Extracellular proteins known to be regulated by the global regulators sarA and agr displayed protein levels in accordance with what is known regarding the effects of these regulators. For example, cysteine protease (SspB), endopeptidase (SspA), staphopain (ScpA), and aureolysin (Aur) were higher in abundance in the sarA and sarA agr mutants than in strain UAMS-1. The immunoglobulin G (IgG)-binding protein (Sbi), immunodominant staphylococcal antigen A (IsaA), IgG-binding protein A (Spa), and the heme-iron-binding protein (IsdA) were most abundant in the agr mutant background. Proteins whose abundance was decreased in the sarA mutant included fibrinogen-binding protein (Fib [Efb]), IsaA, lipase 1 and 2, and two proteins identified as putative leukocidin F and S subunits of the two-component leukotoxin family. Collectively, this approach identified 1,263 proteins (matches of two peptides or more) and provided a convenient and reliable way of identifying proteins and comparing their relative abundances. JF - Journal of bacteriology AU - Jones, Richard C AU - Deck, Joanna AU - Edmondson, Ricky D AU - Hart, Mark E AD - Divisions of Microbiology, Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079-9502, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 5265 EP - 5278 VL - 190 IS - 15 KW - Agr protein, Staphylococcus aureus KW - 0 KW - Bacterial Proteins KW - DNA Transposable Elements KW - Proteome KW - SarA protein, Staphylococcus aureus KW - Trans-Activators KW - Index Medicus KW - Electrophoresis, Polyacrylamide Gel KW - Chromatography, Liquid KW - Tandem Mass Spectrometry KW - Mutagenesis, Insertional KW - Staphylococcus aureus -- physiology KW - Gene Expression Regulation, Bacterial KW - Bacterial Proteins -- genetics KW - Trans-Activators -- genetics KW - Staphylococcus aureus -- genetics KW - Bacterial Proteins -- metabolism KW - Bacterial Proteins -- isolation & purification KW - Trans-Activators -- physiology KW - Proteome -- analysis KW - Mutation KW - Bacterial Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69323063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Relative+quantitative+comparisons+of+the+extracellular+protein+profiles+of+Staphylococcus+aureus+UAMS-1+and+its+sarA%2C+agr%2C+and+sarA+agr+regulatory+mutants+using+one-dimensional+polyacrylamide+gel+electrophoresis+and+nanocapillary+liquid+chromatography+coupled+with+tandem+mass+spectrometry.&rft.au=Jones%2C+Richard+C%3BDeck%2C+Joanna%3BEdmondson%2C+Ricky+D%3BHart%2C+Mark+E&rft.aulast=Jones&rft.aufirst=Richard&rft.date=2008-08-01&rft.volume=190&rft.issue=15&rft.spage=5265&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.00383-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-12 N1 - Date created - 2008-07-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Microbiol. 2004 Aug;12(8):378-85 [15276614] N Engl J Med. 2003 Apr 3;348(14):1342-7 [12672861] Proc Natl Acad Sci U S A. 1975 Mar;72(3):1059-62 [1093163] FEBS Lett. 1980 Jun 30;115(2):209-12 [7398877] J Mol Biol. 1982 May 5;157(1):105-32 [7108955] Infect Immun. 1984 May;44(2):434-8 [6201445] Antimicrob Agents Chemother. 1982 Aug;22(2):277-83 [6821457] Biochem J. 1988 May 15;252(1):87-93 [3138972] J Clin Microbiol. 1988 Oct;26(10):1939-49 [2846632] Mol Gen Genet. 1989 Nov;219(3):480-5 [2622452] J Bacteriol. 1991 Oct;173(20):6313-20 [1717437] Infect Immun. 1995 Sep;63(9):3373-80 [7642265] Infect Immun. 1997 Jan;65(1):95-100 [8975897] FEMS Microbiol Lett. 1997 Jun 15;151(2):139-44 [9228746] Infect Immun. 1999 Mar;67(3):1086-92 [10024547] J Exp Med. 1999 Mar 15;189(6):907-18 [10075974] J Bacteriol. 2005 Jan;187(2):576-92 [15629929] Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1169-74 [15657139] Curr Microbiol. 2005 Jan;50(1):47-51 [15696259] Bioinformatics. 2005 Mar 1;21(5):617-23 [15501914] Infect Immun. 2005 Aug;73(8):4793-802 [16040992] Clin Microbiol Rev. 2000 Jan;13(1):16-34, table of contents [10627489] Trends Microbiol. 2000 May;8(5):231-7 [10785640] Mol Microbiol. 2000 Jun;36(6):1197-205 [10931273] FEMS Immunol Med Microbiol. 2000 Oct;29(2):145-53 [11024354] Infect Immun. 2001 Mar;69(3):1521-7 [11179322] Clin Infect Dis. 2001 May 15;32 Suppl 2:S114-32 [11320452] Curr Top Microbiol Immunol. 2001;257:53-83 [11417122] Proteomics. 2001 Apr;1(4):480-93 [11681202] J Bacteriol. 2001 Dec;183(24):7341-53 [11717293] J Biol Chem. 2002 Jan 4;277(1):243-50 [11684686] Infect Immun. 2002 Feb;70(2):470-80 [11796572] Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2293-8 [11830639] Microbiol Mol Biol Rev. 2002 Mar;66(1):39-63; table of contents [11875127] Mol Microbiol. 2002 Mar;43(6):1603-14 [11952908] Mol Microbiol. 2003 Jun;48(6):1429-49 [12791129] J Bacteriol. 2003 Aug;185(15):4410-7 [12867449] Vet Res. 2003 Sep-Oct;34(5):689-716 [14556701] J Bacteriol. 2003 Nov;185(22):6686-94 [14594843] J Bacteriol. 2003 Dec;185(23):6928-37 [14617657] Anal Chem. 2003 Dec 15;75(24):6912-21 [14670053] Antimicrob Agents Chemother. 2004 Jan;48(1):275-80 [14693550] FEMS Immunol Med Microbiol. 2004 Jan 15;40(1):1-9 [14734180] Int J Med Microbiol. 2003 Dec;293(6):391-401 [14760970] J Bacteriol. 2004 Feb;186(4):1175-81 [14762013] Infect Immun. 2004 Apr;72(4):2160-9 [15039339] Vet Microbiol. 2004 Apr 19;99(3-4):269-79 [15066729] Clin Infect Dis. 2004 Apr 15;38(8):1049-55 [15095205] FEMS Microbiol Rev. 2004 May;28(2):183-200 [15109784] Annu Rev Biophys Biomol Struct. 2004;33:297-316 [15139815] Microbes Infect. 2004 May;6(6):604-8 [15158195] Anal Chem. 2004 Jul 15;76(14):4193-201 [15253663] Mol Microbiol. 2005 Nov;58(4):1087-101 [16262792] Nat Cell Biol. 2006 Apr;8(4):358-66 [16531994] Microbiology. 2006 Oct;152(Pt 10):3075-90 [17005987] Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16942-7 [17075065] Nucleic Acids Res. 2007 Jan;35(Database issue):D193-7 [17142230] FEMS Immunol Med Microbiol. 2007 Mar;49(2):288-95 [17328763] Nat Med. 2007 Dec;13(12):1510-4 [17994102] FEBS Lett. 2002 Apr 24;517(1-3):72-8 [12062412] Clin Microbiol Rev. 2002 Jul;15(3):430-8 [12097250] Infect Immun. 2002 Dec;70(12):6680-7 [12438342] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Apr 5;787(1):179-95 [12659740] Proteomics. 2004 Oct;4(10):3034-47 [15378746] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.00383-08 ER - TY - JOUR T1 - Identification of residues outside of the receptor binding domain that influence the infectivity and tropism of porcine endogenous retrovirus. AN - 69318787; 18508891 AB - Identification of determinants of human tropism of porcine endogenous retrovirus (PERV) is critical to understanding the risk of transmission of PERV to recipients of porcine xenotransplantation products. Previously, we showed that a chimeric envelope cDNA encoding the 360 N-terminal residues of the human-tropic PERV envelope class A (PERV-A) SU and the 130 C-terminal residues of the pig-tropic PERV-C SU and all of TM (PERV-A/C) showed a 100-fold decrease in infectivity titer on human cells (M. Gemeniano, O. Mpanju, D. R. Salomon, M. V. Eiden, and C. A. Wilson, Virology 346:108-117, 2006). To identify residues important for human cell infection, we performed site-directed mutagenesis on each of the nine residues, singly or in combination, that distinguish the C-terminal region of PERV-C from PERV-A. Of the nine amino acids, two single-amino-acid substitutions, Q374R and I412V, restored the infectivity of human cells to the chimeric PERV-A/C to a titer equivalent to that of PERV-A. In contrast, PERV-A/C mutant envelope Q439P resulted in undetectable infection of human cells and an approximately 1,000-fold decrease in control pig cells. Mutation of K441R rescued mutants that carried Q439P, suggesting an incompatibility between the proline residue at this position and the presence of KK in the proteolytic cleavage signal. We confirmed this incompatibility with vectors carrying PERV-A envelope mutant R462K that were also rendered noninfectious. Finally, tropism of vectors carrying PERV-C envelope mutants with only four amino acid changes in the C terminus of PERV-C envelope, NHRQ436YNRP plus K441R, was shifted to one similar to that of PERV-A. Our results show an important and previously unrecognized role for infectivity and tropism for residues at the C terminus of SU. JF - Journal of virology AU - Argaw, Takele AU - Figueroa, Mariel AU - Salomon, Daniel R AU - Wilson, Carolyn A AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, 8800 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 7483 EP - 7491 VL - 82 IS - 15 KW - Gene Products, env KW - 0 KW - Recombinant Fusion Proteins KW - Index Medicus KW - Swine KW - Recombinant Fusion Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Animals KW - Sequence Alignment KW - Amino Acid Substitution -- genetics KW - Humans KW - Recombinant Fusion Proteins -- genetics KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Cell Line KW - Gene Products, env -- metabolism KW - Virus Attachment KW - Endogenous Retroviruses -- physiology KW - Endogenous Retroviruses -- genetics KW - Gene Products, env -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69318787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Identification+of+residues+outside+of+the+receptor+binding+domain+that+influence+the+infectivity+and+tropism+of+porcine+endogenous+retrovirus.&rft.au=Argaw%2C+Takele%3BFigueroa%2C+Mariel%3BSalomon%2C+Daniel+R%3BWilson%2C+Carolyn+A&rft.aulast=Argaw&rft.aufirst=Takele&rft.date=2008-08-01&rft.volume=82&rft.issue=15&rft.spage=7483&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.00295-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-01 N1 - Date created - 2008-07-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2001 Jun;75(12):5465-72 [11356953] Nat Med. 1997 Mar;3(3):282-6 [9055854] Microbiol Mol Biol Rev. 2001 Sep;65(3):371-89, table of contents [11528001] J Virol. 2000 Jan;74(1):49-56 [10590090] J Virol. 2000 Jan;74(2):899-913 [10623753] J Virol. 2000 Feb;74(4):1815-26 [10644355] J Virol. 2000 Jul;74(13):5754-61 [10846053] Nature. 2000 Sep 7;407(6800):90-4 [10993079] Transplantation. 2000 Oct 15;70(7):1010-6 [11045635] J Virol. 2001 Mar;75(6):2771-5 [11222700] J Virol. 2001 Apr;75(8):3685-95 [11264358] J Virol. 2001 May;75(9):4357-66 [11287584] J Virol. 2001 May;75(10):4551-7 [11312325] J Virol. 2001 Oct;75(19):8888-98 [11533152] J Virol. 2002 Mar;76(6):3045-8 [11861871] J Virol. 2002 Oct;76(19):9673-85 [12208946] J Virol. 2002 Dec;76(23):12369-75 [12414980] Proc Natl Acad Sci U S A. 2003 May 27;100(11):6759-64 [12740431] J Virol. 2003 Nov;77(22):12363-8 [14581574] J Virol. 2004 Mar;78(5):2494-501 [14963150] J Virol. 2004 Mar;78(5):2502-9 [14963152] Transplantation. 2004 Apr 15;77(7):1071-9 [15087774] Virology. 1982 Jul 15;120(1):251-7 [6285602] Virology. 1985 Sep;145(2):335-9 [2992156] J Virol. 1987 May;61(5):1609-14 [3033286] Nature. 1997 Oct 16;389(6652):681-2 [9338777] J Virol. 1998 Apr;72(4):3082-7 [9525633] J Virol. 1998 May;72(5):4503-7 [9557749] Lancet. 1998 Aug 29;352(9129):692-4 [9728985] J Virol. 1998 Dec;72(12):9453-8 [9811678] J Virol. 1998 Dec;72(12):9986-91 [9811736] J Virol. 1999 Jul;73(7):5621-9 [10364311] J Virol. 2004 Dec;78(24):13871-9 [15564495] J Virol. 2004 Dec;78(24):13880-90 [15564496] J Virol. 2005 Jan;79(1):649-54 [15596862] Microbes Infect. 2005 Apr;7(4):658-65 [15876545] J Virol. 2005 Jun;79(12):7868-76 [15919941] Xenotransplantation. 2005 Nov;12(6):450-6 [16202068] J Virol. 2006 Feb;80(4):1619-28 [16439518] Virology. 2006 Mar 1;346(1):108-17 [16309725] J Virol. 2006 Apr;80(7):3135-46 [16537582] J Virol. 2006 Oct;80(20):10258-61 [17005704] AIDS Res Hum Retroviruses. 2006 Oct;22(10):993-7 [17067269] Immunol Cell Biol. 2007 Apr-May;85(3):238-48 [17228325] Virology. 2007 Jun 5;362(2):468-74 [17303204] Xenotransplantation. 2007 May;14(3):222-6 [17489862] J Virol. 1987 Sep;61(9):2852-6 [3039173] J Virol. 1991 Aug;65(8):4461-9 [1649341] J Virol. 1991 Nov;65(11):5975-82 [1717711] J Virol. 1992 Feb;66(2):865-74 [1370559] J Virol. 1992 Aug;66(8):4632-8 [1321266] J Virol. 1993 Aug;67(8):4712-21 [8331726] J Virol. 1994 May;68(5):3207-19 [7512161] J Virol. 1995 Feb;69(2):713-9 [7815534] Virology. 2001 Jul 5;285(2):177-80 [11437652] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00295-08 ER - TY - JOUR T1 - Silicosis mortality among young adults in the United States, 1968-2004. AN - 69316008; 18521821 AB - To describe silicosis deaths in young (aged 15-44) adults in the U.S. during 1968-2004. We analyzed the National Center for Health Statistics multiple cause-of-death records. Compared with silicosis decedents aged >or=45 years (n = 15,643), young decedents (n = 237) were more likely to have silicosis listed as the underlying cause of death (74.3% vs. 48.2%, P < 0.001), to be female (9.3% vs. 2.2%, P < 0.001) and black (37.1% vs. 11.7%, P < 0.001). Twenty-nine young silicosis decedents had industry and occupation information available. Occupations in construction and manufacturing industries were associated with significantly elevated proportionate mortality ratios for young silicosis deaths. Silicosis deaths occur among young adults. Because these deaths are likely to reflect more intense and recent exposures, the follow-back investigations into the work sites where these individuals were exposed to silica should be conducted. JF - American journal of industrial medicine AU - Mazurek, Jacek M AU - Attfield, Michael D AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia WV26 505, USA. acq8@cdc.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 568 EP - 578 VL - 51 IS - 8 KW - Index Medicus KW - Humans KW - Death Certificates KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Sex Distribution KW - Male KW - Female KW - Age Distribution KW - Silicosis -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69316008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLOS+Medicine&rft.atitle=A+Mechanism+for+the+Inhibition+of+Neural+Progenitor+Cell+Proliferation+by+Cocaine&rft.au=Lee%2C+Chun-Ting%3BChen%2C+Jia%3BHayashi%2C+Teruo%3BTsai%2C+Shang-Yi%3BSanchez%2C+Joseph+F%3BErrico%2C+Stacie+L%3BAmable%2C+Rose%3BSu%2C+Tsung-Ping%3BLowe%2C+Ross+H%3BHuestis%2C+Marilyn+A%3BShen%2C+James%3BBecker%2C+Kevin+G%3BGeller%2C+Herbert+M%3BFreed%2C+William+J%3BGraeber%2C+Manuel&rft.aulast=Lee&rft.aufirst=Chun-Ting&rft.date=2008-06-01&rft.volume=5&rft.issue=6&rft.spage=e117&rft.isbn=&rft.btitle=&rft.title=PLOS+Medicine&rft.issn=15491277&rft_id=info:doi/10.1371%2Fjournal.pmed.0050117 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-20 N1 - Date created - 2008-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20597 ER - TY - JOUR T1 - Childhood agricultural and adult occupational exposures to organic dusts in a population-based case-control study of systemic lupus erythematosus. AN - 69310756; 18625648 AB - Organic dust exposure can influence the development and symptoms of immune-related diseases such as atopy and asthma, but has rarely been examined in relation to systemic autoimmunity. The present analyses explore the association of lifetime farm and occupational organic dust exposures with systemic lupus erythematosus (SLE) in recently diagnosed patients (n = 265) compared with controls (n = 355) frequency matched by age, sex and state. Questionnaire data included childhood farm residence, childhood and adult experience with specific crops, and adult work in textiles, hog or poultry processing and paper or furniture manufacture. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression models including age, sex, state, race, education and silica exposure. Overall childhood or adult farm contact and childhood farm residence were not associated with SLE. Farm contact with livestock was inversely associated with SLE (OR = 0.55, 95% CI 0.35, 0.88). This effect was most pronounced among those with childhood farm residence and both childhood and adult livestock exposure (OR = 0.19; 95% CI 0.06, 0.63), but was difficult to separate from adult exposure to grains or corn. Other adult occupational exposures were not associated with SLE risk overall, regardless of childhood farm residence or livestock exposure, although an inverse association was seen among non-smokers (OR = 0.59; 95% CI 0.33, 1.1), particularly for textile work (OR = 0.34; 95% CI 0.19, 0.64). These exploratory findings support the development of studies to specifically investigate the effects of organic dust exposure on SLE risk, with particular attention to exposure assessment and characterization of demographics, smoking and other occupational exposures. JF - Lupus AU - Parks, C G AU - Cooper, G S AU - Dooley, M A AU - Park, M M AU - Treadwell, E L AU - Gilkeson, G S AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. parks1@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 711 EP - 719 VL - 17 IS - 8 SN - 0961-2033, 0961-2033 KW - Dust KW - 0 KW - Index Medicus KW - Paper KW - Humans KW - Crops, Agricultural KW - Adult KW - Environmental Exposure KW - Case-Control Studies KW - Animal Husbandry KW - Wood KW - Child KW - Adolescent KW - Male KW - Female KW - Industry KW - Occupational Exposure KW - Agriculture KW - Lupus Erythematosus, Systemic -- immunology KW - Lupus Erythematosus, Systemic -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69310756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lupus&rft.atitle=Childhood+agricultural+and+adult+occupational+exposures+to+organic+dusts+in+a+population-based+case-control+study+of+systemic+lupus+erythematosus.&rft.au=Parks%2C+C+G%3BCooper%2C+G+S%3BDooley%2C+M+A%3BPark%2C+M+M%3BTreadwell%2C+E+L%3BGilkeson%2C+G+S&rft.aulast=Parks&rft.aufirst=C&rft.date=2008-08-01&rft.volume=17&rft.issue=8&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Lupus&rft.issn=09612033&rft_id=info:doi/10.1177%2F0961203308089436 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-04 N1 - Date created - 2008-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0961203308089436 ER - TY - JOUR T1 - Independent and Joint Effects of Socioeconomic, Behavioral, and Neighborhood Characteristics on Physical Inactivity and Activity Levels Among US Children and Adolescents AN - 61688436; 200821799 AB - This study examines the independent and joint associations between several socioeconomic and behavioral characteristics and physical activity (PA) and inactivity prevalence among 68,288 US children aged 6-17 years. The 2003 National Survey of Children's Health was used to estimate PA prevalence. Multivariate logistic regression was used to estimate odds of activity and inactivity and adjusted prevalence, while least squares regression was used to model mean number of days of physical inactivity (PIA) in past month. The prevalence of PA varied substantially by socioeconomic and behavioral characteristics, with older, female, non-English speaking, and metropolitan children and those with lower socioeconomic status (SES) and neighborhood social capital having higher inactivity and lower activity levels. Children who watched television 3+ h/day had 60% higher adjusted odds of PIA and 30% lower odds of PA than those who watched television <3 h/day. Children experiencing inadequate sleep during the entire week had 55% higher odds of PIA and 29% lower odds of PA than those who experienced 5+ nights of adequate sleep during the week. Children whose both parents were physically inactive had 147% higher odds of PTA and 46% lower odds of PA than children whose parents were both physically active. Differentials in PIA by ethnicity, SES, television viewing, and parental inactivity were greater for Younger than for older children. Subgroups such as older, female adolescents, children from socially disadvantaged households and neighborhoods, and those in metropolitan areas should be targeted for the promotion of regular physical activity and reduced television viewing time. Adapted from the source document. JF - Journal of Community Health AU - Singh, Gopal K AU - Kogan, Michael D AU - Siahpush, Mohammad AU - van Dyck, Peter C AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA gsingh@hrsa.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 206 EP - 216 PB - Springer, New York NY VL - 33 IS - 4 SN - 0094-5145, 0094-5145 KW - Childhood physical activity, Inactivity, Ethnicity, Socioeconomic status, Social capital, Neighborhood safety, Television viewing, Sleep deprivation, Parental behavior, United States KW - Television Viewing KW - Ethnic Groups KW - Socioeconomic Status KW - Physical Fitness KW - Sleep KW - Disadvantaged KW - United States of America KW - Metropolitan Areas KW - Cultural Capital KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61688436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Independent+and+Joint+Effects+of+Socioeconomic%2C+Behavioral%2C+and+Neighborhood+Characteristics+on+Physical+Inactivity+and+Activity+Levels+Among+US+Children+and+Adolescents&rft.au=Singh%2C+Gopal+K%3BKogan%2C+Michael+D%3BSiahpush%2C+Mohammad%3Bvan+Dyck%2C+Peter+C&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2008-08-01&rft.volume=33&rft.issue=4&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-008-9094-8 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-08-07 N1 - Number of references - 28 N1 - Last updated - 2016-09-28 N1 - CODEN - JCMHBR N1 - SubjectsTermNotLitGenreText - Television Viewing; Sleep; United States of America; Physical Fitness; Socioeconomic Status; Metropolitan Areas; Ethnic Groups; Cultural Capital; Disadvantaged DO - http://dx.doi.org/10.1007/s10900-008-9094-8 ER - TY - JOUR T1 - Preventing unintentional pediatric injuries: a tailored intervention for parents and providers AN - 57258637; 200822276 AB - The purpose of this study was to determine the efficacy of providing (i) tailored injury prevention information (T-IPI) to parents and (ii) concurrent T-IPI to parents and providers to promote parent adoption of safety practices. During well-child visits, parents of children ages 4 and younger completed a computer assessment and were randomized to receive generic injury prevention information, T-IPI or T-IPI supplemented with a tailored summary for providers. Follow-up assessments were completed by telephone 1 month later. Parents receiving T-IPI alone or with supplementary provider information were more likely to report adopting a new injury prevention behavior than those receiving generic information (49 and 45%, respectively, compared with 32%; odds ratio = 2.0 and 1.9, respectively), and these effects were greatest among the least educated parents. In addition, more complicated behavior changes were reported by those receiving tailored information. Provider receipt of feedback did not result in significantly different provider-parent communication or change in parents' safety practices. Providing parents with individually tailored pediatric injury prevention information may be an effective method for delivering injury prevention anticipatory guidance. Tailoring may have particular utility for more complicated behaviors and for communication with less educated parents. Adapted from the source document. JF - Health Education Research AU - Nansel, Tonja R AU - Weaver, Nancy L AU - Jacobsen, Heather A AU - Glasheen, Cristie AU - Kreuter, Matthew W AD - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA nanselt@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 656 EP - 669 PB - Oxford University Press, UK VL - 23 IS - 4 SN - 0268-1153, 0268-1153 KW - Assessment KW - Paediatrics KW - Prevention KW - Injuries KW - Safety KW - Parents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57258637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+Research&rft.atitle=Preventing+unintentional+pediatric+injuries%3A+a+tailored+intervention+for+parents+and+providers&rft.au=Nansel%2C+Tonja+R%3BWeaver%2C+Nancy+L%3BJacobsen%2C+Heather+A%3BGlasheen%2C+Cristie%3BKreuter%2C+Matthew+W&rft.aulast=Nansel&rft.aufirst=Tonja&rft.date=2008-08-01&rft.volume=23&rft.issue=4&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Health+Education+Research&rft.issn=02681153&rft_id=info:doi/10.1093%2Fher%2Fcym041 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - HRTPE2 N1 - SubjectsTermNotLitGenreText - Parents; Prevention; Injuries; Paediatrics; Safety; Assessment DO - http://dx.doi.org/10.1093/her/cym041 ER - TY - JOUR T1 - Computer Simulation of Heat Transfer in Different Tissue Layers of Body Extremities Under Heat Stress in Deep Anesthetic Condition AN - 216796505; 18619092 AB - Many mathematical models of thermoregulation in humans have been developed, so far. These models appeared to be very useful tools for studying temperature regulation in humans under adverse environmental conditions. However, no one discussed the heat transfer characteristics of denervated subjects. Thus, the present study is concerned with aspects of the passive system for denervated subjects: (1) modeling the human body extremities (2) modeling heat transport mechanism within the body and at its periphery. The present model was simulated using the software (Wintherm 8.0, Thermoanalytics, USA) for different body segments to predict the heat flow between body core and skin surface with changes in environmental temperature with fixed relative humidity and wind velocity. The simulated model for comparative study of internal temperature distribution of hand, arm, leg and feet segments yielded remarkably good results and observed to be in trends with previously cited work under ambient environmental condition and at controlled room temperature. Models could be used to measure the temperature distribution in human limbs during local hyperthermia and to investigate the interaction between limbs and the thermal environment. [PUBLICATION ABSTRACT] JF - Journal of Medical Systems AU - Aggarwal, Yogender AU - Karan, Bhuwan Mohan AU - Das, Barda Nand AU - Sinha, Rakesh Kumar Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 283 EP - 90 CY - New York PB - Springer Science & Business Media VL - 32 IS - 4 SN - 0148-5598 KW - Medical Sciences--Computer Applications KW - Simulation KW - Heat transfer KW - Anesthesia KW - Temperature KW - Humans KW - Models, Biological KW - Computer Simulation KW - Heat Stress Disorders -- physiopathology KW - Body Temperature Regulation -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/216796505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomputing&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Systems&rft.atitle=Computer+Simulation+of+Heat+Transfer+in+Different+Tissue+Layers+of+Body+Extremities+Under+Heat+Stress+in+Deep+Anesthetic+Condition&rft.au=Aggarwal%2C+Yogender%3BKaran%2C+Bhuwan+Mohan%3BDas%2C+Barda+Nand%3BSinha%2C+Rakesh+Kumar&rft.aulast=Aggarwal&rft.aufirst=Yogender&rft.date=2008-08-01&rft.volume=32&rft.issue=4&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Systems&rft.issn=01485598&rft_id=info:doi/10.1007%2Fs10916-008-9133-0 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2008 N1 - Document feature - References N1 - Last updated - 2014-07-26 DO - http://dx.doi.org/10.1007/s10916-008-9133-0 ER - TY - JOUR T1 - A meta-analysis of studies investigating the effects of lead exposure on nerve conduction AN - 21336129; 11722340 AB - Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log sub(10) blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the median, ulnar, and radial nerves in the arm, and in the deep peroneal nerve in the leg. Distal latencies of the median, ulnar, and deep peroneal nerves were longer. No changes in the amplitudes of compound muscle or nerve action potentials were detected. The lowest concentration at which a relationship with blood lead could be detected was 33.0kg/dl for the nerve conduction velocity of the median sensory nerve. Lead may reduce nerve conduction velocity by acting directly on peripheral nerves or by acting indirectly, for example, on the kidney or liver. JF - Archives of Toxicology AU - Krieg, Edward F AU - Chrislip, David W AU - Brightwell, WStephen AD - Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-22, Cincinnati, OH, 45226, USA, erk3@cdc.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 531 EP - 542 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 82 IS - 8 SN - 0340-5761, 0340-5761 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Health & Safety Science Abstracts KW - Sensory neurons KW - Muscles KW - Arm KW - Lead KW - Blood levels KW - Models KW - Leg KW - Blood KW - Action potential KW - peroneal nerve KW - Reviews KW - Liver KW - Kidney KW - Nerve conduction KW - Peripheral nerves KW - N3 11028:Neuropharmacology & toxicology KW - H 14000:Toxicology KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21336129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=A+meta-analysis+of+studies+investigating+the+effects+of+lead+exposure+on+nerve+conduction&rft.au=Krieg%2C+Edward+F%3BChrislip%2C+David+W%3BBrightwell%2C+WStephen&rft.aulast=Krieg&rft.aufirst=Edward&rft.date=2008-08-01&rft.volume=82&rft.issue=8&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/10.1007%2Fs00204-008-0292-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Sensory neurons; Muscles; Arm; Lead; Models; Leg; Blood; Action potential; peroneal nerve; Reviews; Kidney; Liver; Nerve conduction; Peripheral nerves; Blood levels DO - http://dx.doi.org/10.1007/s00204-008-0292-z ER - TY - JOUR T1 - Modeling the Violation of Reward Maximization and Invariance in Reinforcement Schedules AN - 21038838; 8517087 AB - It is often assumed that animals and people adjust their behavior to maximize reward acquisition. In visually cued reinforcement schedules, monkeys make errors in trials that are not immediately rewarded, despite having to repeat error trials. Here we show that error rates are typically smaller in trials equally distant from reward but belonging to longer schedules (referred to as 'schedule length effect'). This violates the principles of reward maximization and invariance and cannot be predicted by the standard methods of Reinforcement Learning, such as the method of temporal differences. We develop a heuristic model that accounts for all of the properties of the behavior in the reinforcement schedule task but whose predictions are not different from those of the standard temporal difference model in choice tasks. In the modification of temporal difference learning introduced here, the effect of schedule length emerges spontaneously from the sensitivity to the immediately preceding trial. We also introduce a policy for general Markov Decision Processes, where the decision made at each node is conditioned on the motivation to perform an instrumental action, and show that the application of our model to the reinforcement schedule task and the choice task are special cases of this general theoretical framework. Within this framework, Reinforcement Learning can approach contextual learning with the mixture of empirical findings and principled assumptions that seem to coexist in the best descriptions of animal behavior. As examples, we discuss two phenomena observed in humans that often derive from the violation of the principle of invariance: 'framing,' wherein equivalent options are treated differently depending on the context in which they are presented, and the 'sunk cost' effect, the greater tendency to continue an endeavor once an investment in money, effort, or time has been made. The schedule length effect might be a manifestation of these phenomena in monkeys. Author Summary Theories of rational behavior are built on a number of principles, including the assumption that subjects adjust their behavior to maximize their long-term returns and that they should work equally hard to obtain a reward in situations where the effort to obtain reward is the same (called the invariance principle). Humans, however, are sensitive to the manner in which equivalent choices are presented, or 'framed,' and often have a greater tendency to continue an endeavor once an investment in money, effort, or time has been made, a phenomenon known as 'sunk cost' effect. In a similar manner, when monkeys must perform different numbers of trials to obtain a reward, they work harder as the number of trials already performed increases, even though both the work remaining and the forthcoming reward are the same in all situations. Methods from the theory of Reinforcement Learning, which usually provide learning strategies aimed at maximizing returns, cannot model this violation of invariance. Here we generalize a prominent method of Reinforcement Learning so as to explain the violation of invariance, without losing the ability to model behaviors explained by standard Reinforcement Learning models. This generalization extends our understanding of how animals and humans learn and behave. JF - PLoS Computational Biology AU - La Camera, Giancarlo AU - Richmond, Barry J AU - Friston, Karl J AD - Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 4 IS - 8 SN - 1553-734X, 1553-734X KW - Biotechnology and Bioengineering Abstracts KW - Reinforcement schedules KW - Learning KW - Motivation KW - Reinforcement KW - Problem solving KW - Temporal discrimination learning KW - Computer applications KW - Nodes KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21038838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Computational+Biology&rft.atitle=Modeling+the+Violation+of+Reward+Maximization+and+Invariance+in+Reinforcement+Schedules&rft.au=La+Camera%2C+Giancarlo%3BRichmond%2C+Barry+J%3BFriston%2C+Karl+J&rft.aulast=La+Camera&rft.aufirst=Giancarlo&rft.date=2008-08-01&rft.volume=4&rft.issue=8&rft.spage=e1000131&rft.isbn=&rft.btitle=&rft.title=PLoS+Computational+Biology&rft.issn=1553734X&rft_id=info:doi/10.1371%2Fjournal.pcbi.1000131 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Reinforcement schedules; Learning; Motivation; Reinforcement; Problem solving; Nodes; Computer applications; Temporal discrimination learning; Models DO - http://dx.doi.org/10.1371/journal.pcbi.1000131 ER - TY - JOUR T1 - Phenotypic and Genotypic Analyses of Neisseria gonorrhoeae Isolates That Express Frequently Recovered PorB PIA Variable Region Types Suggest that Certain P1a Porin Sequences Confer a Selective Advantage for Urogenital Tract Infection AN - 20895584; 8406376 AB - Typing of the porB variable region (VR) is an epidemiological tool that classifies gonococcal strains based on sequence differences in regions of the porB gene that encode surface-exposed loops. The frequent isolation of certain porB VR types suggests that some porin sequences confer a selective advantage during infection and/or transmission. Alternatively, certain porin types may be markers of strains that are successful due to factors unrelated to porin. In support of the first hypothesis, here we show urogenital tract isolates representing the most common PIA VR types identified in an urban clinic in Baltimore, MD, over a 10-year period belonged to several different clonal types, as determined by pulsed-field gel electrophoresis (PFGE). Serum resistance, which was confirmed by factor H and C4b-binding protein binding studies, was more often associated with gonococcal the most common VR types. In contrast, three porin-independent phenotypes, namely, lactoferrin utilization, b-lactamase production, and multiple transferable resistance (Mtr), were segregated with the PFGE cluster and not with the VR type. Data combined with another PIA strain collection showed a strong correlation between serum resistance and the most common VR types. A comparison of VR typing hybridization patterns and nucleotide sequences of 12 porB1a genes suggests that certain porin loop 1, 3, 6, and/or 7 sequences may play a role in the serum resistance phenotype. We conclude that some PorB PIA sequences confer a survival or transmission advantage in the urogenital tract, perhaps via increased resistance to complement-mediated killing. The capacity of some porin types to evade a porin-specific adaptive immune response must also be considered. JF - Infection and Immunity AU - Garvin, Lotisha E AU - Bash, Margaret C AU - Keys, Christine AU - Warner, Douglas M AU - Ram, Sanjay AU - Shafer, William M AU - Jerse, Ann E AD - Department of Microbiology and Immunology. Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services University, Bethesda, Maryland. Division of Bacterial, Allergenic, and Parasitic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland. Division of Microbiological Studies, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland. Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia. Laboratories of Microbial Pathogenesis, VA Medical Research Service, Veterans Affairs Medical Center, Decatur, Georgia Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 3700 EP - 3709 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 8 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Data processing KW - porB gene KW - Porins KW - Complement KW - Survival KW - Infection KW - C4b-binding protein KW - Neisseria gonorrhoeae KW - lactoferrin KW - Pulsed-field gel electrophoresis KW - Immune response KW - b-Lactamase KW - Variable region KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20895584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Phenotypic+and+Genotypic+Analyses+of+Neisseria+gonorrhoeae+Isolates+That+Express+Frequently+Recovered+PorB+PIA+Variable+Region+Types+Suggest+that+Certain+P1a+Porin+Sequences+Confer+a+Selective+Advantage+for+Urogenital+Tract+Infection&rft.au=Garvin%2C+Lotisha+E%3BBash%2C+Margaret+C%3BKeys%2C+Christine%3BWarner%2C+Douglas+M%3BRam%2C+Sanjay%3BShafer%2C+William+M%3BJerse%2C+Ann+E&rft.aulast=Garvin&rft.aufirst=Lotisha&rft.date=2008-08-01&rft.volume=76&rft.issue=8&rft.spage=3700&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; porB gene; Porins; lactoferrin; Complement; Pulsed-field gel electrophoresis; Survival; b-Lactamase; Immune response; C4b-binding protein; Infection; Variable region; Neisseria gonorrhoeae ER - TY - JOUR T1 - In vitro dermal absorption and metabolism of D&C red no. 17 in human and porcine skin AN - 20872342; 8390753 AB - D&C red no. 17 is approved for use in externally applied drug and cosmetic applications, in amounts consistent with good manufacturing practice. Concerns about the safety of the color additive (1-[4-phenylazophenylazo]-2-napthol (PAN) is the primary color constituent) have been raised due to potential metabolic cleavage of PAN to yield 4-aminoazobenzene. 14C-PAN was applied in a commercially available suntan vehicle containing D&C red no. 17 to viable porcine and non-viable (cadaver) human skin in flow-through diffusion cells. At the end of 24h, unabsorbed material was removed from the skin and some cells were allowed to continue for an additional 48h. In human skin, 0.07% and 0.17% of the applied dose were absorbed into the receptor fluid after 24 and 72h, respectively. At the end of 24h, 12.5% of the applied dose remained in the skin, which did not decrease at 72h. When PAN was applied to viable porcine skin for 24h, 0.3% of the applied dose was absorbed and 12.7% remained in the skin. Additional studies to simulate short-term exposure were completed with PAN applied to the skin for only 15min, and absorption was determined for 24 and 72h. These studies in human cadaver skin found 0.02% and 0.08% of the applied dose in the receptor fluid after 24 and 72h, respectively. Viable porcine skin studies with the 15min application resulted in receptor fluid values of 0.1% of the applied dose after 24h. Lipophilic receptor fluids composed of the non-ionic surfactant Volpo 20 at wt% concentrations of 1%, 3%, or 6% in water did not increase partitioning of PAN from the skin into the receptor fluid. No metabolism of PAN was found in viable porcine skin when examined by HPLC. In conclusion, skin absorption of PAN from a commercially available suntan product was low. JF - International Journal of Cosmetic Science AU - Yourick, Jeffrey J AU - Sasik, Camille T AU - Bronaugh, Robert L AD - Office of Cosmetics and Colors, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 310 EP - 311 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 30 IS - 4 KW - Health & Safety Science Abstracts KW - Skin KW - Consumer products KW - cosmetics KW - Absorption KW - Diffusion KW - Surfactants KW - Drugs KW - Additives KW - Metabolism KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20872342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cosmetic+Science&rft.atitle=In+vitro+dermal+absorption+and+metabolism+of+D%26amp%3BC+red+no.+17+in+human+and+porcine+skin&rft.au=Yourick%2C+Jeffrey+J%3BSasik%2C+Camille+T%3BBronaugh%2C+Robert+L&rft.aulast=Yourick&rft.aufirst=Jeffrey&rft.date=2008-08-01&rft.volume=30&rft.issue=4&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cosmetic+Science&rft.issn=1468-2494&rft_id=info:doi/10.1111%2Fj.1468-2494.2007.00405_5.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Skin; Absorption; Consumer products; Metabolism; cosmetics; Additives; Diffusion; Drugs; Surfactants DO - http://dx.doi.org/10.1111/j.1468-2494.2007.00405_5.x ER - TY - JOUR T1 - Maternal and fetal exposure to bisphenol A in Korea AN - 20868479; 8379147 AB - Bisphenol A (BPA) is a well-known endocrine disrupter used widely. Despite the potential risk of human exposure to BPA, little information exists concerning maternal and fetal exposure to BPA during pregnancy in Korea. This study purposed to evaluate the correlation between maternal and fetal exposure, and to determine exposure levels to BPA in Korean pregnant women and their fetuses. Maternal blood and umbilical cord blood were collected from 300 subjects, and total BPA levels were measured. Blood BPA concentrations ranged from non-detectable to 66.48 mu g/L in pregnant women and from non-detectable to 8.86 mu g/L in umbilical cords. Serum BPA levels in most pregnant women were higher than in corresponding fetal umbilical cords and a positive correlation was found between in maternal and fetal BPA concentrations (p<0.05). JF - Reproductive Toxicology AU - Lee, Y J AU - Ryu, HY AU - Kim, H K AU - Min, C S AU - Lee, J H AU - Kim, E AU - Nam, B H AU - Park, J H AU - Jung, J Y AU - Jang, D D AU - Park, E Y AU - Lee, KH AU - Ma, J Y AU - Won, H S AU - Im, M W AU - Leem, J H AU - Hong, Y C AU - Yoon, H S AD - National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea, hsyoon0956@kfda.go.kr Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 413 EP - 419 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 25 IS - 4 SN - 0890-6238, 0890-6238 KW - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - Bisphenol A KW - Bioaccumulation KW - endocrine disruptors KW - Korea, Rep. KW - Fetuses KW - Umbilical cord KW - Pregnancy KW - H 14000:Toxicology KW - R2 23060:Medical and environmental health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20868479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Maternal+and+fetal+exposure+to+bisphenol+A+in+Korea&rft.au=Lee%2C+Y+J%3BRyu%2C+HY%3BKim%2C+H+K%3BMin%2C+C+S%3BLee%2C+J+H%3BKim%2C+E%3BNam%2C+B+H%3BPark%2C+J+H%3BJung%2C+J+Y%3BJang%2C+D+D%3BPark%2C+E+Y%3BLee%2C+KH%3BMa%2C+J+Y%3BWon%2C+H+S%3BIm%2C+M+W%3BLeem%2C+J+H%3BHong%2C+Y+C%3BYoon%2C+H+S&rft.aulast=Lee&rft.aufirst=Y&rft.date=2008-08-01&rft.volume=25&rft.issue=4&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2008.05.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bisphenol A; Umbilical cord; Fetuses; Pregnancy; Bioaccumulation; endocrine disruptors; Korea, Rep. DO - http://dx.doi.org/10.1016/j.reprotox.2008.05.058 ER - TY - JOUR T1 - Interlaboratory evaluation of an extraction and fluorescence method for the determination of trace beryllium in soils AN - 20239465; 8480328 AB - Analytical methods for the determination of trace beryllium in soils are needed so that anthropogenic sources of this element can be distinguished from native (background) levels of beryllium. In this work, a collaborative interlaboratory evaluation of a new extraction and fluorescence-based procedure for determining beryllium in soil samples was carried out to fulfil method validation requirements for ASTM International voluntary consensus standard test methods. A Canadian reference material, CCRMP Till-1 soil, with a background beryllium concentration of 2.4 kg g super(-1), was selected for study. This certified reference material (CRM) was spiked and homogenized with varying levels of beryllium oxide in order to give batches of material with beryllium concentrations of 4.36 c 0.69, 11.5 c 0.7, 124 c 7 and 246 c 16 kg g super(-1) (c values are standard deviations). In the interlaboratory study (ILS), which was carried out in accordance with an applicable ASTM International standard practice (ASTM E691), samples of these spiked soils were subjected to extraction in dilute ammonium bifluoride at 690 C for 40 h. Fluorescence measurement of the extracted beryllium was carried out via detection using the high quantum yield fluorophore, hydroxybenzoquinoline sulfonate (HBQS). Interlaboratory precision estimates from six participating laboratories ranged from 0.048 to 0.103 (relative standard deviations) for the five different beryllium concentrations. Pooled bias estimates resulting from this ILS were between -0.049 and 0.177 for the various beryllium levels. These figures of merit support promulgation of the analytical procedure as an ASTM International standard test method. JF - Journal of Environmental Monitoring AU - Cronin, J P AU - Agrawal, A AU - Adams, L AU - Tonazzi, JCL AU - Brisson, MJ AU - White, K T AU - Marlow, D AU - Ashley, K AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, M.S. R-7, Cincinnati, OH, 45226-1998, USA, KAshley@cdc.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 955 EP - 960 VL - 10 IS - 8 SN - 1464-0325, 1464-0325 KW - Environment Abstracts; Pollution Abstracts KW - Soil KW - Ammonium KW - sulfonates KW - Fluorescence KW - anthropogenic factors KW - Beryllium KW - International standardization KW - P 5000:LAND POLLUTION KW - ENA 15:Renewable Resources-Terrestrial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20239465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Interlaboratory+evaluation+of+an+extraction+and+fluorescence+method+for+the+determination+of+trace+beryllium+in+soils&rft.au=Cronin%2C+J+P%3BAgrawal%2C+A%3BAdams%2C+L%3BTonazzi%2C+JCL%3BBrisson%2C+MJ%3BWhite%2C+K+T%3BMarlow%2C+D%3BAshley%2C+K&rft.aulast=Cronin&rft.aufirst=J&rft.date=2008-08-01&rft.volume=10&rft.issue=8&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb804313b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Soil; Ammonium; sulfonates; Fluorescence; anthropogenic factors; Beryllium; International standardization DO - http://dx.doi.org/10.1039/b804313b ER - TY - JOUR T1 - The pharmacogenomics of P-glycoprotein and its role in veterinary medicine AN - 19714515; 8392279 AB - Despite advancements in pharmacogenetics in human medicine, the incorporation of pharmacogenetics into veterinary medicine is still in its early stages of development. To date, efforts to understand the pharmacologic impact of genetic variation in veterinary species have largely focused on genes encoding for the membrane transporter, P-glycoprotein (P-gp). The emphasis on the role of P-gp is largely because of safety concerns associated with the use of some macrocyclic lactones in dogs. Because of the body of information available on this topic, we use P-gp as a platform for understanding the importance of population diversity in veterinary medicine. The impact of P-gp on drug pharmacokinetics and pharmacodynamics is considered, along with endogenous and exogenous factors that can modulate P-gp activity. The review includes discussion of how population diversity in P-gp activity can lead to susceptibility to certain diseases or alter patient response to environmental stress or pharmaceutical intervention. In addition, phenotypic diversity also needs to be considered, as demonstrated by the impact of P-gp up-regulation and drug resistance. The aim of this review was to set the stage for further exploration into the impact of genetic and phenotypic variability on drug pharmacokinetics, disease propensity, product formulation and drug response in both companion and food-producing animals. JF - Journal of Veterinary Pharmacology and Therapeutics AU - Martinez, M AU - MODRIC, S AU - Sharkey, M AU - Troutman, L AU - Walker, L AU - Mealey, K AD - Center for Veterinary Medicine, Office of New Animal Drug Evaluation, Rockville, MD, USA, marilyn.martinez@fda.hhs.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 285 EP - 300 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 31 IS - 4 SN - 0140-7783, 0140-7783 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - pharmacogenomics KW - Food KW - Drug resistance KW - Genetic diversity KW - Developmental stages KW - lactones KW - Pharmacokinetics KW - Pharmacogenetics KW - P-Glycoprotein KW - Veterinary medicine KW - Reviews KW - Pharmaceuticals KW - Environmental stress KW - Drugs KW - Pharmacodynamics KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19714515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.atitle=The+pharmacogenomics+of+P-glycoprotein+and+its+role+in+veterinary+medicine&rft.au=Martinez%2C+M%3BMODRIC%2C+S%3BSharkey%2C+M%3BTroutman%2C+L%3BWalker%2C+L%3BMealey%2C+K&rft.aulast=Martinez&rft.aufirst=M&rft.date=2008-08-01&rft.volume=31&rft.issue=4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.issn=01407783&rft_id=info:doi/10.1111%2Fj.1365-2885.2008.00964.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - pharmacogenomics; Drug resistance; Food; Developmental stages; Genetic diversity; lactones; Pharmacogenetics; Pharmacokinetics; Veterinary medicine; P-Glycoprotein; Reviews; Pharmaceuticals; Environmental stress; Drugs; Pharmacodynamics DO - http://dx.doi.org/10.1111/j.1365-2885.2008.00964.x ER - TY - JOUR T1 - Evaluation of a rapid one-step immunochromatographic test and two immunoenzymatic assays for the detection of anti-Treponema pallidum antibodies AN - 19647210; 8407767 AB - BACKGROUND: The control of syphilis depends on screening of the population at risk and is usually performed using the Treponema pallidum particle agglutination test (TPPA). Outside Europe the rapid plasma reagin test (RPR) or venereal disease research laboratory test is most often used for screening purposes. Because of the drawbacks in current diagnostic procedures, ie, long turnaround time, the need is felt for a rapid and simple test that can potentially be performed on whole blood. OBJECTIVE AND STUDY DESIGN: In this study a one-step immunochromatographic test (Biorapid Syphilis) and two ELISA, the Bioelisa Syphilis 3.0 and ETI-Treponema Plus, were evaluated. METHODS: Serum samples were collected between February 2000 and May 2006 at the University Hospital in Maastricht, The Netherlands. 145 TPPA-positive sera, confirmed by fluorescent treponemal antibody absorption (FTA-Abs, treponemal test) and/or RPR (non-treponemal) were included. Furthermore, 41 sera from healthy controls and 144 TPPA-negative sera from controls with underlying conditions that might interfere with T pallidum serology were collected. RESULTS: The sensitivity and specificity of the Biorapid Syphilis, Bioelisa Syphilis 3.0 and ETI-Treponema Plus were 92% and 79%, 100% and 100% and 100% and 100%, respectively, with our selected sera. CONCLUSIONS: The performance of both ELISA was excellent in our study and is favoured over the TPPA because of its ability to be run on an automated system. The sensitivity and specificity of the Biorapid Syphilis were considered too low to implement the test in a hospital laboratory in a developed country but it might be useful in primary healthcare settings in developing countries. JF - Sexually Transmitted Infections AU - van Dommelen, L AU - Smismans, A AU - Goossens, V J AU - Damoiseaux, J AU - Bruggeman, C A AU - van Tiel, F H AU - Hoebe, C J P A AD - Medical Microbiology, Maastricht Infection Centre, University Hospital Maastricht, Maastricht, The Netherlands Department of Infectious Diseases, South Limburg Municipal Public Health Service, Heerlen, The Netherlands Department of Clinical and Experimental Immunology, University Hospital Maastricht, Maastricht, The Netherlands Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 292 EP - 296 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 84 IS - 4 SN - 1368-4973, 1368-4973 KW - Microbiology Abstracts B: Bacteriology KW - Blood KW - Rapid plasma reagin test KW - Enzyme-linked immunosorbent assay KW - Antibodies KW - Agglutination KW - Treponema pallidum KW - Globus pallidus KW - Syphilis KW - Serology KW - Developing countries KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19647210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=Evaluation+of+a+rapid+one-step+immunochromatographic+test+and+two+immunoenzymatic+assays+for+the+detection+of+anti-Treponema+pallidum+antibodies&rft.au=van+Dommelen%2C+L%3BSmismans%2C+A%3BGoossens%2C+V+J%3BDamoiseaux%2C+J%3BBruggeman%2C+C+A%3Bvan+Tiel%2C+F+H%3BHoebe%2C+C+J+P+A&rft.aulast=van+Dommelen&rft.aufirst=L&rft.date=2008-08-01&rft.volume=84&rft.issue=4&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Rapid plasma reagin test; Blood; Agglutination; Antibodies; Enzyme-linked immunosorbent assay; Globus pallidus; Developing countries; Serology; Syphilis; Hospitals; Treponema pallidum ER - TY - JOUR T1 - Rapid detection of ricin in cosmetics and elimination of artifacts associated with wheat lectin AN - 20063429; 8418576 AB - Ricin can be detected in cosmetics at 0.005 ?g/mL in the analytical sample using lateral flow devices (LFDs). Wheat germ, an ingredient used in skin care products is also a potential source of wheat lectin. False positives were observed when wheat lectin was added to LFDs from two manufacturers, irrespective of whether the LFD was specific for ricin, Staphylococcus enterotoxin B (SEB), or botulinum toxin. In contrast, pea and peanut lectins did not cause false positives. Substitution of the buffer supplied with the LFDs with a buffer containing 2.5% non-fat milk powder eliminated the occurrence of false positives. This substitution increased the LOD to 0.01 ?g/mL ricin, which is an acceptable level for screening cosmetics for contamination by ricin. JF - Journal of Immunological Methods AU - Dayan-Kenigsberg, J AU - Bertocchi, A AU - Garber, EAE AD - Center for Food Safety and Applied Nutrition, HFS-716, 5100 Paint Branch Pkwy., College Park, MD, 20740, USA, Eric.Garber@fda.hhs.gov Y1 - 2008/07/31/ PY - 2008 DA - 2008 Jul 31 SP - 251 EP - 254 PB - Elsevier Science, P.O. Box 211 Langford Lane Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 336 IS - 2 SN - 0022-1759, 0022-1759 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Arachis hypogaea KW - Powder KW - Skin KW - Milk KW - Wheat germ KW - Staphylococcus KW - Ricin KW - Nuts KW - Lectins KW - Cosmetics KW - Food contamination KW - Triticum aestivum KW - Botulinum toxin KW - enterotoxin B KW - F 06900:Methods KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20063429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Rapid+detection+of+ricin+in+cosmetics+and+elimination+of+artifacts+associated+with+wheat+lectin&rft.au=Dayan-Kenigsberg%2C+J%3BBertocchi%2C+A%3BGarber%2C+EAE&rft.aulast=Dayan-Kenigsberg&rft.aufirst=J&rft.date=2008-07-31&rft.volume=336&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2008.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Powder; Milk; Skin; Wheat germ; Ricin; Nuts; Cosmetics; Lectins; Botulinum toxin; Food contamination; enterotoxin B; Triticum aestivum; Arachis hypogaea; Staphylococcus DO - http://dx.doi.org/10.1016/j.jim.2008.05.007 ER - TY - JOUR T1 - Mapping prefrontal circuits in vivo with manganese-enhanced magnetic resonance imaging in monkeys. AN - 69347078; 18650340 AB - Manganese-enhanced magnetic resonance imaging (MEMRI) provides a powerful tool to study multisynaptic circuits in vivo and thereby to link information about neural structure and function within individual subjects. Making the best use of MEMRI in monkeys requires minimizing manganese-associated neurotoxicity, maintaining sensitivity to manganese-dependent signal changes and mapping transport throughout the brain without a priori anatomical hypotheses. Here, we performed intracortical injections of isotonic MnCl(2), comparisons of preinjection and postinjection scans, and voxelwise statistical mapping. Isotonic MnCl(2) did not cause cell death at the injection site, damage to downstream targets of manganese transport, behavioral deficits, or changes in neuronal responsiveness. We detected and mapped manganese transport throughout cortical-subcortical circuits by using voxelwise statistical comparisons of at least 10 preinjection and two postinjection scans. We were able to differentiate between focal and diffuse projection fields and to distinguish between the topography of striatal projections from orbitofrontal and anterior cingulate cortex in a single animal. This MEMRI approach provides a basis for combining circuit-based anatomical analyses with simultaneous single-unit recordings and/or functional magnetic resonance imaging in individual monkeys. Such studies will enhance our interpretations of functional data and our understanding of how neuronal activity is transformed as it propagates through a circuit. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Simmons, Janine M AU - Saad, Ziad S AU - Lizak, Martin J AU - Ortiz, Michael AU - Koretsky, Alan P AU - Richmond, Barry J AD - Department of Health and Human Services, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA. Y1 - 2008/07/23/ PY - 2008 DA - 2008 Jul 23 SP - 7637 EP - 7647 VL - 28 IS - 30 KW - Manganese KW - 42Z2K6ZL8P KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Action Potentials -- physiology KW - Animals KW - Conditioning, Classical -- physiology KW - Neural Pathways -- physiology KW - Action Potentials -- drug effects KW - Haplorhini KW - Photic Stimulation -- methods KW - Neural Pathways -- blood supply KW - Oxygen -- blood KW - Neural Pathways -- anatomy & histology KW - Time Factors KW - Image Processing, Computer-Assisted KW - Female KW - Male KW - Magnetic Resonance Imaging KW - Manganese -- pharmacology KW - Brain Mapping KW - Prefrontal Cortex -- anatomy & histology KW - Prefrontal Cortex -- physiology KW - Prefrontal Cortex -- blood supply KW - Image Enhancement -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69347078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=Practice-specific+risk+perceptions+and+self-reported+food+safety+practices&rft.au=Levy%2C+Alan+S%3BChoini%C3%A8re%2C+Conrad+J%3BFein%2C+Sara+B&rft.aulast=Levy&rft.aufirst=Alan&rft.date=2008-06-01&rft.volume=28&rft.issue=3&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2008.01051.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-07-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Neurophysiol. 2000 Apr;83(4):1864-76 [10758098] J Cereb Blood Flow Metab. 2008 Apr;28(4):832-40 [17987047] J Neurosci Methods. 2000 Nov 15;103(1):63-71 [11074096] Magn Reson Med. 2001 Sep;46(3):424-9 [11550231] Neuroscience. 2002;112(2):467-74 [12044464] Neuron. 2002 May 30;34(5):685-700 [12062017] Magn Reson Med. 2003 Jul;50(1):33-9 [12815676] Neuroimage. 2003 Nov;20(3):1591-600 [14642470] Magn Reson Med. 2004 Jan;51(1):22-6 [14705041] Neuroimage. 2004 Mar;21(3):914-23 [15006658] Exp Brain Res. 1983;49(1):93-115 [6861938] J Neurosci. 1985 Mar;5(3):776-94 [2983048] Arch Toxicol. 1987;61(1):46-52 [3439874] Arch Toxicol. 1992;66(5):359-64 [1319135] Science. 1993 Feb 5;259(5096):819-21 [7679223] Exp Neurol. 1993 Mar;120(1):89-94 [8477830] J Neurochem. 1994 Jan;62(1):205-16 [7505311] Brain Res. 1994 Sep 19;657(1-2):124-32 [7820609] J Comp Neurol. 1994 Dec 15;350(3):337-56 [7533796] Magn Reson Med. 1995 May;33(5):636-47 [7596267] J Neurosci. 1995 Jul;15(7 Pt 1):4851-67 [7623116] J Neurosci. 1995 Sep;15(9):5999-6013 [7666184] Neurology. 1996 Feb;46(2):492-8 [8614520] Comput Biomed Res. 1996 Jun;29(3):162-73 [8812068] NMR Biomed. 1997 Jun-Aug;10(4-5):171-8 [9430344] Magn Reson Med. 1998 Nov;40(5):740-8 [9797158] Neurotoxicology. 1999 Apr-Jun;20(2-3):227-38 [10385886] NMR Biomed. 2004 Dec;17(8):532-43 [15617052] NMR Biomed. 2004 Dec;17(8):554-68 [15617054] NMR Biomed. 2004 Dec;17(8):595-601 [15761948] Magn Reson Med. 2006 Mar;55(3):604-11 [16470592] Magn Reson Imaging. 2006 May;24(4):349-58 [16677940] J Neurosci. 2006 Aug 9;26(32):8368-76 [16899732] Cereb Cortex. 2008 Jan;18(1):93-103 [17434918] Neuroimage. 2008 Apr 1;40(2):458-72 [18222710] J Comp Neurol. 2000 Sep 25;425(3):447-70 [10972944] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1523/JNEUROSCI.1488-08.2008 ER - TY - JOUR T1 - Effects of sampling artifacts on occupational samples of diesel particulate matter. AN - 69478385; 18756633 AB - Total carbon (TC) is sometimes used to measure or characterize diesel particulate matter (DPM) in occupational settings such as underground mines. DPM samples are collected on quartz fiber filters. When using quartz fiber filters, adsorption of gas phase organic carbon (OC) has been reported, causing a positive bias in the particulate TC results (adsorption artifact). Most of the data on the sampling artifacts and corrections applyto environmental air sampling, where samples are collected at a much higher filter face velocity and the OC concentrations are generally much lower relative to occupational sampling. In this study, we investigated the effects of adsorption artifact on samples from occupational settings. Samples were collected with and without denuders to determine the amount of gas phase OC collected and the accuracy of certain corrections. In underground stone mines, the adsorption artifact was found to positively bias the particulate TC by greater than 20% for filter loadings below 25 microg/cm2 TC (8-h time weighted average = 262 microg/m3). The tandem filter correction reduced the effect of the artifact, as high as 60% of the TC value, to less than 11% for laboratory data. It also significantly reduced the effect of the artifact obtained for field samples. JF - Environmental science & technology AU - Noll, James AU - Birch, M Eileen AD - Pittsburgh Research Laboratory, U.S. Department of Health and Human Services, PHS, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 626 Cochrans Mill Road, Pittsburgh, Pennsylvania 15236, USA. JIN1@cdc.gov Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 5223 EP - 5228 VL - 42 IS - 14 SN - 0013-936X, 0013-936X KW - Air Pollutants, Occupational KW - 0 KW - Particulate Matter KW - Vehicle Emissions KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Filtration -- methods KW - Particle Size KW - Humans KW - Adsorption KW - Carbon -- chemistry KW - Artifacts KW - Air Pollutants, Occupational -- analysis KW - Particulate Matter -- analysis KW - Environmental Monitoring -- methods KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69478385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Effects+of+sampling+artifacts+on+occupational+samples+of+diesel+particulate+matter.&rft.au=Noll%2C+James%3BBirch%2C+M+Eileen&rft.aulast=Noll&rft.aufirst=James&rft.date=2008-07-15&rft.volume=42&rft.issue=14&rft.spage=5223&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-22 N1 - Date created - 2008-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ixabepilone in combination with capecitabine and as monotherapy for treatment of advanced breast cancer refractory to previous chemotherapies. AN - 69315004; 18628451 AB - To describe the considerations leading to marketing approval of ixabepilone in combination with capecitabine and as monotherapy for the treatment of advanced breast cancer that is refractory to other chemotherapies. Data from one randomized multicenter trial comparing combination therapy with ixabepilone and capecitabine to capecitabine alone were analyzed for support of the combination therapy indication. For monotherapy, a single-arm trial of ixabepilone was analyzed. Supporting data came from an additional single-arm combination therapy study and two single-arm monotherapy studies. In patients with metastatic or locally advanced breast cancer who had disease progression on or following an anthracycline and a taxane, ixabepilone plus capecitabine showed an improvement in progression-free survival compared with capecitabine alone {median progression-free survival, 5.7 [95% confidence interval (95% CI), 4.8-6.7] versus 4.1 (95% CI, 3.1-4.3) months, stratified log-rank P < 0.0001; hazard ratio, 0.69 (95% CI, 0.58-0.83)}. As monotherapy for patients who had disease progression on or following an anthracycline, a taxane, and capecitabine, ixabepilone as monotherapy showed a 12% objective response rate by independent blinded review and 18% by investigator assessment. The major toxicities from ixabepilone therapy were peripheral neuropathy and myelosuppression, particularly neutropenia. On October 16, 2007, the Food and Drug Administration approved ixabepilone for injection in combination with capecitabine or as monotherapy for the treatment of patients with advanced breast cancer who have experienced disease progression on previous chemotherapies. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Lechleider, Robert J AU - Kaminskas, Edvardas AU - Jiang, Xiaoping AU - Aziz, Robeena AU - Bullock, Julie AU - Kasliwal, Ravindra AU - Harapanhalli, Ravi AU - Pope, Sarah AU - Sridhara, Rajeshwari AU - Leighton, John AU - Booth, Brian AU - Dagher, Ramzi AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20903, USA. Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 4378 EP - 4384 VL - 14 IS - 14 SN - 1078-0432, 1078-0432 KW - Epothilones KW - 0 KW - Deoxycytidine KW - 0W860991D6 KW - Capecitabine KW - 6804DJ8Z9U KW - ixabepilone KW - K27005NP0A KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Disease-Free Survival KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Epothilones -- adverse effects KW - Aged KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- adverse effects KW - Neoplasm Recurrence, Local -- drug therapy KW - Deoxycytidine -- adverse effects KW - Neoplasm Metastasis -- drug therapy KW - Fluorouracil -- analogs & derivatives KW - Deoxycytidine -- administration & dosage KW - Middle Aged KW - Female KW - Epothilones -- administration & dosage KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- mortality KW - Drug Resistance, Neoplasm KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69315004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Ixabepilone+in+combination+with+capecitabine+and+as+monotherapy+for+treatment+of+advanced+breast+cancer+refractory+to+previous+chemotherapies.&rft.au=Lechleider%2C+Robert+J%3BKaminskas%2C+Edvardas%3BJiang%2C+Xiaoping%3BAziz%2C+Robeena%3BBullock%2C+Julie%3BKasliwal%2C+Ravindra%3BHarapanhalli%2C+Ravi%3BPope%2C+Sarah%3BSridhara%2C+Rajeshwari%3BLeighton%2C+John%3BBooth%2C+Brian%3BDagher%2C+Ramzi%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Lechleider&rft.aufirst=Robert&rft.date=2008-07-15&rft.volume=14&rft.issue=14&rft.spage=4378&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-08-0015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-16 N1 - Date created - 2008-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-08-0015 ER - TY - JOUR T1 - Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV. AN - 69281505; 18505381 AB - Injection drug users (IDUs) who successfully clear hepatitis C virus (HCV) have a reduced risk of developing chronic reinfection, despite their continuing exposure to the virus. To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years). HCV-specific T cell responses were assessed in proliferation, enzyme-linked immunospot (ELISPOT), interferon (IFN)-gamma secretion, and cytotoxicity assays, whereas HCV-specific antibodies were assessed in enzyme immunoassays (EIAs), chemiluminescent assays, and in vitro neutralization assays. HCV-specific T cell proliferation and IFN-gamma production were more common in nonviremic EIA-positive IDUs (16 [94%] of 17 IDUs) than in viremic EIA-positive IDUs (9 [45%] of 20 IDUs) (P= .003). They were also noted in 16 (62%) of 26 nonviremic EIA-negative IDUs. In contrast, 19 (90%) of 21 viremic IDUs displayed neutralizing antibodies (nAbs), compared with 9 (56%) of 16 nonviremic EIA-positive IDUs (P= .04) and 0 of 24 nonviremic EIA-negative IDUs. Nonviremic IDUs with nAbs were older (P= .0115) than those without nAbs, but these groups did not differ in terms of either injection drug use duration or HCV-specific T cell responses. The reduced risk of HCV persistence in IDUs previously recovered from HCV infection correlated with T cell responses, and prolonged antigenic stimulation appears to be required to maintain humoral responses. JF - The Journal of infectious diseases AU - Mizukoshi, Eishiro AU - Eisenbach, Christoph AU - Edlin, Brian R AU - Newton, Kimberly P AU - Raghuraman, Sukanya AU - Weiler-Normann, Christina AU - Tobler, Leslie H AU - Busch, Michael P AU - Carrington, Mary AU - McKeating, Jane A AU - O'Brien, Thomas R AU - Rehermann, Barbara AD - Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA. Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 203 EP - 212 VL - 198 IS - 2 SN - 0022-1899, 0022-1899 KW - Cytokines KW - 0 KW - Viral Proteins KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Viral Proteins -- genetics KW - Humans KW - Cytokines -- secretion KW - Leukocytes, Mononuclear -- immunology KW - Reverse Transcriptase Polymerase Chain Reaction KW - Risk Assessment KW - Genotype KW - Lymphocyte Activation KW - Cross-Sectional Studies KW - Leukocytes, Mononuclear -- virology KW - Viremia -- epidemiology KW - Incidence KW - Interferon-gamma -- blood KW - United States -- epidemiology KW - T-Lymphocytes -- immunology KW - Hepacivirus -- pathogenicity KW - Hepatitis C -- transmission KW - Hepacivirus -- genetics KW - Substance Abuse, Intravenous -- immunology KW - Hepatitis C -- epidemiology KW - Hepatitis C -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69281505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Service+Review&rft.atitle=Funneling+Child+Welfare+Consumers+into+and+through+the+Mental+Health+System%3A+Assessment%2C+Referral%2C+and+Quality+Issues&rft.au=Fedoravicius%2C+Nicole%3BMcMillen%2C+J+Curtis%3BRowe%2C+Jill+E%3BKagotho%2C+Njeri%3BWare%2C+Norma+C&rft.aulast=Fedoravicius&rft.aufirst=Nicole&rft.date=2008-06-01&rft.volume=82&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Social+Service+Review&rft.issn=00377961&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-07-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Semin Liver Dis. 2005 Feb;25(1):7-17 [15731994] J Clin Invest. 1998 Nov 1;102(9):1758-65 [9802890] J Clin Microbiol. 2005 May;43(5):2477-80 [15872288] Am J Trop Med Hyg. 2005 Jul;73(1):44-9 [16014830] Hepatology. 2006 Nov;44(5):1139-45 [17058216] Gastroenterology. 2007 Feb;132(2):667-78 [17258731] Gastroenterology. 2007 Feb;132(2):654-66 [17258733] Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6025-30 [17392433] Hepatology. 2007 Sep;46(3):666-71 [17657818] J Exp Med. 2000 May 1;191(9):1499-512 [10790425] Nat Med. 2000 May;6(5):578-82 [10802716] J Virol. 2001 Feb;75(3):1229-35 [11152496] Am J Public Health. 2001 Jan;91(1):46-7 [11189823] J Clin Invest. 2001 Feb;107(3):341-9 [11160158] Lancet. 2001 May 5;357(9266):1397-401 [11356437] Am J Public Health. 2002 Mar;92(3):385-7 [11867316] Lancet. 2002 Apr 27;359(9316):1478-83 [11988247] J Virol. 2002 Jun;76(12):6104-13 [12021343] J Exp Med. 2003 Mar 3;197(5):633-42 [12615904] J Infect Dis. 2003 Mar 15;187(6):974-81 [12660944] J Virol. 2003 Apr;77(8):4781-93 [12663785] Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7271-6 [12761383] J Exp Med. 2003 Jun 16;197(12):1645-55 [12810686] Trends Immunol. 2003 Aug;24(8):456-64 [12909460] Science. 2003 Oct 24;302(5645):659-62 [14576438] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14199-204 [14617769] J Immunol. 2004 Jan 1;172(1):483-92 [14688358] J Virol. 2004 Feb;78(3):1575-81 [14722311] J Clin Microbiol. 2004 Feb;42(2):610-7 [14766824] Hepatology. 2004 Jul;40(1):87-97 [15239090] Hepatology. 2004 Jul;40(1):98-107 [15239091] Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10149-54 [15220475] Gastroenterology. 2004 Sep;127(3):924-36 [15362047] AIDS. 1988 Feb;2(1):55-60 [3128998] West J Med. 1992 Jan;156(1):30-5 [1310362] N Engl J Med. 1992 Dec 31;327(27):1899-905 [1280771] JAMA. 1994 Jan 12;271(2):115-20 [8264065] Medicine (Baltimore). 1995 Jul;74(4):212-20 [7623656] Lancet. 1995 Oct 14;346(8981):1006-7 [7475549] Am J Public Health. 1995 Nov;85(11):1531-7 [7485666] Am J Public Health. 1996 May;86(5):642-54 [8629714] NIDA Res Monogr. 1995;157:212-30 [8684438] J Infect Dis. 1997 Aug;176(2):518-22 [9237722] J Infect Dis. 1997 Oct;176(4):859-66 [9333142] Nature. 1998 Mar 5;392(6671):86-9 [9510252] Nat Rev Immunol. 2005 Mar;5(3):215-29 [15738952] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/589510 ER - TY - JOUR T1 - The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats AN - 20936605; 8346707 AB - Acrylamide (AA) is an important industrial chemical that is neurotoxic in rodents and humans and carcinogenic in rodents. The observation of cancer in endocrine-responsive tissues in Fischer 344 rats has prompted hypotheses of hormonal dysregulation, as opposed to DNA damage, as the mechanism for tumor induction by AA. The current investigation examines possible evidence for disruption of the hypothalamic-pituitary-thyroid axis from 14 days of repeated exposure of male Fischer 344 rats to doses of AA that range from one that is carcinogenic after lifetime exposure (2.5 mg/kg/d), an intermediate dose (10 mg/kg/d), and a high dose (50 mg/kg/d) that is neurotoxic for this exposure time. The endpoints selected include: serum levels of thyroid and pituitary hormones; target tissue expression of genes involved in hormone synthesis, release, and receptors; neurotransmitters in the CNS that affect hormone homeostasis; and histopathological evaluation of target tissues. These studies showed virtually no evidence for systematic alteration of the hypothalamic-pituitary-thyroid axis and do not support hormone dysregulation as a plausible mechanism for AA-induced thyroid cancer in the Fischer 344 rat. Specifically, there were no significant changes in: 1) mRNA levels in hypothalamus or pituitary for TRH, TSH, thyroid hormone receptor alpha and beta , as well 10 other hormones or releasing factors; 2) mRNA levels in thyroid for thyroglobulin, thyroid peroxidase, sodium iodide symporter, or type I deiodinases; 3) serum TSH or T3 levels (T4 was decreased at high dose only); 4) dopaminergic tone in the hypothalamus and pituitary or importantly 5) increased cell proliferation (Mki67 mRNA and Ki-67 protein levels were not increased) in thyroid or pituitary. These negative findings are consistent with a genotoxic mechanism of AA carcinogenicity based on metabolism to glycidamide and DNA adduct formation. Clarification of this mechanistic dichotomy may be useful in human cancer risk assessments for AA. JF - Toxicology and Applied Pharmacology AU - Bowyer, J F AU - Latendresse, J R AU - Delongchamp, R R AU - Muskhelishvili, L AU - Warbritton, A R AU - Thomas, M AU - Tareke, E AU - McDaniel, L P AU - Doerge AD - National Center for Toxicological Research, Division of Biochemical Toxicology, 3900 NCTR Road, Jefferson, AR 72079, USA, daniel.doerge@fda.hhs.gov Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 208 EP - 215 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 230 IS - 2 SN - 0041-008X, 0041-008X KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Risk assessment KW - Central nervous system KW - Homeostasis KW - Pituitary hormones KW - Gene expression KW - Thyrotropin-releasing hormone KW - Thyroid hormone receptors KW - Thyroglobulin KW - Carcinogenicity KW - Pituitary KW - thyroid cancer KW - Thyroxine KW - Thyroid-stimulating hormone KW - Neurotransmitters KW - Iodide peroxidase KW - DNA adducts KW - Genotoxicity KW - Hypothalamic-pituitary-thyroid axis KW - Triiodothyronine KW - Tumors KW - Neurochemistry KW - mRNA KW - Serum levels KW - DNA damage KW - Acrylamide KW - Neurotoxicity KW - Cell proliferation KW - sodium iodide symporter KW - Metabolism KW - N 14820:DNA Metabolism & Structure KW - N3 11028:Neuropharmacology & toxicology KW - X 24320:Food Additives & Contaminants KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20936605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=The+effects+of+subchronic+acrylamide+exposure+on+gene+expression%2C+neurochemistry%2C+hormones%2C+and+histopathology+in+the+hypothalamus-pituitary-thyroid+axis+of+male+Fischer+344+rats&rft.au=Bowyer%2C+J+F%3BLatendresse%2C+J+R%3BDelongchamp%2C+R+R%3BMuskhelishvili%2C+L%3BWarbritton%2C+A+R%3BThomas%2C+M%3BTareke%2C+E%3BMcDaniel%2C+L+P%3BDoerge&rft.aulast=Bowyer&rft.aufirst=J&rft.date=2008-07-15&rft.volume=230&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2008.02.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Central nervous system; Homeostasis; Pituitary hormones; Gene expression; Thyrotropin-releasing hormone; Thyroglobulin; Thyroid hormone receptors; Pituitary; Carcinogenicity; thyroid cancer; Thyroxine; Neurotransmitters; Thyroid-stimulating hormone; Iodide peroxidase; DNA adducts; Genotoxicity; Triiodothyronine; Hypothalamic-pituitary-thyroid axis; Neurochemistry; Tumors; mRNA; Serum levels; DNA damage; Acrylamide; Neurotoxicity; sodium iodide symporter; Cell proliferation; Metabolism DO - http://dx.doi.org/10.1016/j.taap.2008.02.028 ER - TY - JOUR T1 - The Membrane Form of Tumor Necrosis Factor Is Sufficient to Mediate Partial Innate Immunity to Francisella tularensis Live Vaccine Strain AN - 19808599; 8611913 AB - Here we characterize Francisella tularensis live vaccine strain (LVS) infection in total tumor necrosis factor (TNF) knockout (KO) mice and in transgenic mice expressing only the membrane form of TNF (memTNF). MemTNF mice, but not TNF KO mice, survived low-dose, sublethal LVS infections. Splenic nitric oxide production was impaired in infected memTNF mice and was absent in infected TNF KO mice. Spleen cell production of interferon- gamma , RANTES, and monocyte chemotactic protein-1 was elevated in TNF KO mice, compared with that in WT mice, by days 4-5 after infection, along with transiently increased numbers of CCR2 super(+) cells, whereas memTNF mice had an intermediate phenotype. By day 6 after infection, TNF KO mice, but not memTNF mice, exhibited massive apoptosis in spleens and livers, which shortly preceded their death. Thus, memTNF partially functions to regulate chemokine expression, cell recruitment, and nitric oxide production during primary LVS infection and protects against the induction of apoptosis observed in TNF KO mice. JF - Journal of Infectious Diseases AU - Cowley, S C AU - Goldberg, M F AU - Ho, JA AU - Elkins, K L AD - CBER/FDA, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA, siobhan.cowley@fda.hhs.gov Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 284 EP - 292 VL - 198 IS - 2 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Chemokines KW - Monocyte chemoattractant protein 1 KW - Apoptosis KW - Tumor necrosis factor KW - RANTES KW - Spleen KW - Francisella tularensis KW - Immunity KW - Transgenic mice KW - Infection KW - Liver KW - Nitric oxide KW - Vaccines KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19808599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=The+Membrane+Form+of+Tumor+Necrosis+Factor+Is+Sufficient+to+Mediate+Partial+Innate+Immunity+to+Francisella+tularensis+Live+Vaccine+Strain&rft.au=Cowley%2C+S+C%3BGoldberg%2C+M+F%3BHo%2C+JA%3BElkins%2C+K+L&rft.aulast=Cowley&rft.aufirst=S&rft.date=2008-07-15&rft.volume=198&rft.issue=2&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F589620 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Chemokines; Apoptosis; Monocyte chemoattractant protein 1; Tumor necrosis factor; Spleen; RANTES; Immunity; Infection; Transgenic mice; Liver; Nitric oxide; Vaccines; Francisella tularensis DO - http://dx.doi.org/10.1086/589620 ER - TY - CPAPER T1 - In Vivo Evidence that the Neurovirulence of Mumps Virus Clinical Isolate 88-1961 is a Multigenic Trait T2 - 27th Annual Meeting of the American Society for Virology AN - 41065640; 4913416 JF - 27th Annual Meeting of the American Society for Virology AU - Sauder, Christian AU - Zhang, Cheryl AU - Malik, Tahir AU - Duprex, Paul AU - Carbone, Kathryn AU - Rubin, Steven Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Mumps KW - Clinical isolates KW - Neurovirulence KW - Mumps virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41065640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=In+Vivo+Evidence+that+the+Neurovirulence+of+Mumps+Virus+Clinical+Isolate+88-1961+is+a+Multigenic+Trait&rft.au=Sauder%2C+Christian%3BZhang%2C+Cheryl%3BMalik%2C+Tahir%3BDuprex%2C+Paul%3BCarbone%2C+Kathryn%3BRubin%2C+Steven&rft.aulast=Sauder&rft.aufirst=Christian&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improvement of Growth Characteristics of Influenza B Viruses by Specific Amino Acid Substitutions in Hemagglutinin T2 - 27th Annual Meeting of the American Society for Virology AN - 41065180; 4913746 JF - 27th Annual Meeting of the American Society for Virology AU - Lugovtsev, Vladimir Y AU - Vodeiko, Galina M AU - Levandowski, Roland A AU - Weir, Jerry P Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Amino acids KW - Influenza KW - Viruses KW - Influenza B KW - Hemagglutinins KW - Amino acid substitution KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41065180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Heme-oxygenase+1+Gene+Expression+is+a+Marker+for+Hexavalent+Chromium-Induced+Stress+and+Toxicity+in+Human+Dermal+Fibroblasts&rft.au=Joseph%2C+Pius%3BHe%2C+Quanren%3BUmbright%2C+Christina&rft.aulast=Joseph&rft.aufirst=Pius&rft.date=2008-06-01&rft.volume=103&rft.issue=2&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigation of the Contribution of the Surface and Matrix Proteins of Mumps Virus Strain Urabe AM9 to Neurovirulence T2 - 27th Annual Meeting of the American Society for Virology AN - 41061682; 4913587 JF - 27th Annual Meeting of the American Society for Virology AU - Link, Malen A AU - Sauder, Christian AU - Zhang, Cheryl AU - Duprex, Paul AU - Carbone, Kathryn M AU - Rubin, Steven Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Mumps KW - Matrix protein KW - Neurovirulence KW - Strains KW - Mumps virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41061682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Investigation+of+the+Contribution+of+the+Surface+and+Matrix+Proteins+of+Mumps+Virus+Strain+Urabe+AM9+to+Neurovirulence&rft.au=Link%2C+Malen+A%3BSauder%2C+Christian%3BZhang%2C+Cheryl%3BDuprex%2C+Paul%3BCarbone%2C+Kathryn+M%3BRubin%2C+Steven&rft.aulast=Link&rft.aufirst=Malen&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Protection Induced by a Live Attenuated Matrix Gene (M1) Mutant Virus Against Homologous and Heterologous Influenza Challenges in Mice T2 - 27th Annual Meeting of the American Society for Virology AN - 41060220; 4913596 JF - 27th Annual Meeting of the American Society for Virology AU - Xie, Hang AU - Wu, Zhengqi AU - Liu, Teresa AU - Ye, Zhiping Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Mice KW - Mutants KW - Influenza UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41060220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Mechanism+of+Protection+Induced+by+a+Live+Attenuated+Matrix+Gene+%28M1%29+Mutant+Virus+Against+Homologous+and+Heterologous+Influenza+Challenges+in+Mice&rft.au=Xie%2C+Hang%3BWu%2C+Zhengqi%3BLiu%2C+Teresa%3BYe%2C+Zhiping&rft.aulast=Xie&rft.aufirst=Hang&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of H5N1 Influenza Neuraminidase Stalk Chimeras on Virus Growth T2 - 27th Annual Meeting of the American Society for Virology AN - 41055542; 4913728 JF - 27th Annual Meeting of the American Society for Virology AU - Adamo, Joan E AU - Liu, Teresa AU - Schmeisser, Falko M AU - Ye, Zhiping Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Influenza KW - Chimeras KW - Exo-a-sialidase KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41055542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Analysis+of+H5N1+Influenza+Neuraminidase+Stalk+Chimeras+on+Virus+Growth&rft.au=Adamo%2C+Joan+E%3BLiu%2C+Teresa%3BSchmeisser%2C+Falko+M%3BYe%2C+Zhiping&rft.aulast=Adamo&rft.aufirst=Joan&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Melamine Contaminated Animal Feed Recalls T2 - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AN - 41067328; 4917589 JF - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AU - Alewynse, M G Y1 - 2008/07/07/ PY - 2008 DA - 2008 Jul 07 KW - Animal feeds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41067328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.atitle=Melamine+Contaminated+Animal+Feed+Recalls&rft.au=Alewynse%2C+M+G&rft.aulast=Alewynse&rft.aufirst=M&rft.date=2008-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.issn=&rft_id=info:doi/ L2 - http://adsa.asas.org/meetings/2008/Program-Scientific.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inactivation of Clostridium botulinum Type A Neurotoxin in Milk by High Pressure Processing T2 - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AN - 41066208; 4917328 JF - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AU - Schlesser, J E AU - Gerdes, R AU - Skinner, G E AU - Reddy, N R AU - Parisi, B Y1 - 2008/07/07/ PY - 2008 DA - 2008 Jul 07 KW - Neurotoxins KW - Inactivation KW - Milk KW - Pressure KW - Clostridium botulinum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41066208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.atitle=Inactivation+of+Clostridium+botulinum+Type+A+Neurotoxin+in+Milk+by+High+Pressure+Processing&rft.au=Schlesser%2C+J+E%3BGerdes%2C+R%3BSkinner%2C+G+E%3BReddy%2C+N+R%3BParisi%2C+B&rft.aulast=Schlesser&rft.aufirst=J&rft.date=2008-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.issn=&rft_id=info:doi/ L2 - http://adsa.asas.org/meetings/2008/Program-Scientific.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDAs Food Protection Plan and Import Safety Plan T2 - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AN - 41063163; 4917590 JF - 2008 Joint Annual Meeting of the American Dairy Science Association and the American Society of Animal Science AU - Benz, S A Y1 - 2008/07/07/ PY - 2008 DA - 2008 Jul 07 KW - Imports KW - FDA KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41063163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.atitle=FDAs+Food+Protection+Plan+and+Import+Safety+Plan&rft.au=Benz%2C+S+A&rft.aulast=Benz&rft.aufirst=S&rft.date=2008-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.issn=&rft_id=info:doi/ L2 - http://adsa.asas.org/meetings/2008/Program-Scientific.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease. AN - 69227057; 17956852 AB - Chronic beryllium disease (CBD) is a granulomatous lung disease that occurs primarily in workers who are exposed to beryllium dust or fumes. Although exposure to beryllium is a necessary factor in the pathobiology of CBD, alleles that code for a glutamic acid residue at the 69th position of the HLA-DPbeta1 gene have previously been found to be associated with CBD. To date, 43 HLA-DPbeta1 alleles that code for glutamic acid 69 (E69) have been described. Whether all of these E69 coding alleles convey equal risk of CBD is unknown. The present study demonstrates that, on the one hand, E69 alleloforms of major histocompatibility complex class II antigen-presenting proteins with the greatest negative surface charge convey the highest risk of CBD, and on the other hand, irrespective of allele, they convey equal risk of beryllium sensitization (BeS). In addition, the data suggest that the same alleles that cause the greatest risk of CBD are also important for the progression from BeS to CBD. Alleles convey the highest risk code for E26 in a constant region and for E69, aspartic acid 55 (D55), E56, D84 and E85 in hypervariable regions of the HLA-DPbeta1 chain. Together with the calculated high binding affinities for beryllium, these results suggest that an adverse immune response, leading to CBD, is triggered by chemically specific metal-protein interactions. JF - Journal of the Royal Society, Interface AU - Snyder, James A AU - Demchuk, Eugene AU - McCanlies, Erin C AU - Schuler, Christine R AU - Kreiss, Kathleen AU - Andrew, Michael E AU - Frye, Bonnie L AU - Ensey, James S AU - Stanton, Marcia L AU - Weston, Ainsley AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2008/07/06/ PY - 2008 DA - 2008 Jul 06 SP - 749 EP - 758 VL - 5 IS - 24 SN - 1742-5689, 1742-5689 KW - HLA-DR Antigens KW - 0 KW - HLA-DRB1 Chains KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Alleles KW - Risk Factors KW - Humans KW - Occupational Exposure -- adverse effects KW - Protein Binding -- genetics KW - Chronic Disease KW - Protein Binding -- immunology KW - Male KW - Female KW - Surface Properties KW - Berylliosis -- immunology KW - Berylliosis -- metabolism KW - HLA-DR Antigens -- immunology KW - Beryllium -- metabolism KW - HLA-DR Antigens -- genetics KW - HLA-DR Antigens -- metabolism KW - Models, Biological KW - Berylliosis -- genetics KW - Amino Acid Substitution KW - Beryllium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69227057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Society%2C+Interface&rft.atitle=Impact+of+negatively+charged+patches+on+the+surface+of+MHC+class+II+antigen-presenting+proteins+on+risk+of+chronic+beryllium+disease.&rft.au=Snyder%2C+James+A%3BDemchuk%2C+Eugene%3BMcCanlies%2C+Erin+C%3BSchuler%2C+Christine+R%3BKreiss%2C+Kathleen%3BAndrew%2C+Michael+E%3BFrye%2C+Bonnie+L%3BEnsey%2C+James+S%3BStanton%2C+Marcia+L%3BWeston%2C+Ainsley&rft.aulast=Snyder&rft.aufirst=James&rft.date=2008-07-06&rft.volume=5&rft.issue=24&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Society%2C+Interface&rft.issn=17425689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-22 N1 - Date created - 2008-06-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Allergy Asthma Immunol. 2003 May;90(5 Suppl 2):24-7 [12772947] J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003 Feb;38(2):439-69 [12638707] Environ Health Perspect. 2003 Nov;111(15):1827-34 [14630515] Risk Anal. 2003 Dec;23(6):1211-20 [14641896] J Immunol. 2003 Dec 15;171(12):6910-8 [14662898] Lancet. 2004 Feb 7;363(9407):415-6 [14962519] Nat Genet. 2004 Jul;36(7):664 [15226743] Am J Ind Med. 2004 Aug;46(2):95-103 [15273960] Am J Ind Med. 2004 Nov;46(5):453-62 [15490468] J Occup Med. 1991 Jan;33(1):23-8 [1995798] Science. 1993 Oct 8;262(5131):242-4 [8105536] Int Immunol. 1995 Oct;7(10):1585-91 [8562503] Am J Ind Med. 1997 Oct;32(4):337-40 [9258386] J Immunol. 1999 Aug 1;163(3):1647-53 [10415070] Tissue Antigens. 2004 Dec;64(6):631-49 [15546336] Am J Respir Crit Care Med. 2005 Jan 1;171(1):54-60 [15374840] J Occup Environ Hyg. 2004 Oct;1(10):648-59 [15631056] J Occup Environ Hyg. 2005 Jun;2(6):D48-50 [16020086] DNA Seq. 2005 Jun;16(3):235-6 [16147881] Mutat Res. 2005 Dec 30;592(1-2):68-78 [16054169] Proteomics. 2006 Mar;6(5):1663-75 [16447159] Annu Rev Public Health. 2007;28:259-77 [17094767] Angew Chem Int Ed Engl. 2007;46(15):2669-71 [17348063] J Phys Chem B. 2007 Mar 22;111(11):2873-85 [17388420] Tissue Antigens. 2007 Mar;69(3):290-2 [17493161] J Phys Chem B. 2007 Jun 14;111(23):6425-36 [17508737] Risk Anal. 2000 Feb;20(1):87-99 [10795342] Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12717-22 [11050177] Appl Occup Environ Hyg. 2001 May;16(5):559-67 [11370935] Toxicology. 2001 Aug 13;165(1):27-38 [11551429] Eur Respir J. 2001 Oct;18(4):677-84 [11716174] Am J Respir Crit Care Med. 2002 Mar 15;165(6):788-94 [11897645] Nucleic Acids Res. 2003 Jan 1;31(1):311-4 [12520010] Am J Epidemiol. 2003 Mar 1;157(5):388-98 [12615603] Sarcoidosis Vasc Diffuse Lung Dis. 2003 Jun;20(2):144-8 [12870725] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Origin of Low Mammalian Cell Toxicity in a Class of Highly Active Antimicrobial Amphipathic Helical Peptides AN - 19891878; 8339968 AB - We recently described a novel antimicrobial peptide, RTA3, derived from the commensal organism Streptococcus mitis, with strong anti-Gram-negative activity, low salt sensitivity, and minimal mammalian cell toxicity in vitro and in vivo. This peptide conforms to the positively charged, amphipathic helical peptide motif, but has a positively charged amino acid (Arg-5) on the nonpolar face of the helical structure that is induced upon membrane binding. We surmised that disruption of the hydrophobic face with a positively charged residue plays a role in minimizing eukaryotic cell toxicity, and we tested this using a mutant with an R5L substitution. The greatly enhanced toxicity in the mutant peptide correlated with its ability to bind and adopt helical conformations upon interacting with neutral membranes; the wild type peptide RTA3 did not bind to neutral membranes (binding constant reduced by at least 1000-fold). Spectroscopic analysis indicates that disruption of the hydrophobic face of the parent peptide is accommodated in negatively charged membranes without partial peptide unfolding. These observations apply generally to amphipathic helical peptides of this class as we obtained similar results with a peptide and mutant pair (Chen, Y., Mant, C. T., Farmer, S. W., Hancock, R. E., Vasil, M. L., and Hodges, R. S. (2005) J. Biol. Chem. 280, 12316-12329) having similar structural properties. In contrast to previous interpretations, we demonstrate that these peptides simply do not bind well to membranes (like those of eukaryotes) with exclusively neutral lipids in their external bilayer leaflet. We highlight a significant role for tryptophan in promoting binding of amphipathic helical peptides to neutral bilayers, augmenting the arsenal of strategies to reduce mammalian toxicity in antimicrobial peptides. JF - Journal of Biological Chemistry AU - Hawrani, Ayman AU - Howe, Robin A AU - Walsh, Timothy R AU - Dempsey, Christopher E AD - Biochemistry Department and Department of Cellular and Molecular Medicine, Bristol University, Bristol BS8 1TD, National Public Health Service Cardiff, University Hospital of Wales, Cardiff CF14 4XW, and the Department of Medical Microbiology, Cardiff University, Cardiff CF14 4XN, United Kingdom Y1 - 2008/07/04/ PY - 2008 DA - 2008 Jul 04 SP - 18636 EP - 18645 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 27 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts KW - Tryptophan KW - Amino acids KW - Lipids KW - Commensals KW - Hydrophobicity KW - Toxicity KW - Antimicrobial agents KW - Salts KW - Mammalian cells KW - Streptococcus mitis KW - Antimicrobial peptides KW - Conformation KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - X 24310:Pharmaceuticals KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Origin+of+Low+Mammalian+Cell+Toxicity+in+a+Class+of+Highly+Active+Antimicrobial+Amphipathic+Helical+Peptides&rft.au=Hawrani%2C+Ayman%3BHowe%2C+Robin+A%3BWalsh%2C+Timothy+R%3BDempsey%2C+Christopher+E&rft.aulast=Hawrani&rft.aufirst=Ayman&rft.date=2008-07-04&rft.volume=283&rft.issue=27&rft.spage=18636&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tryptophan; Salts; Amino acids; Mammalian cells; Lipids; Commensals; Hydrophobicity; Toxicity; Antimicrobial peptides; Antimicrobial agents; Conformation; Streptococcus mitis ER - TY - CPAPER T1 - Accuracy of Impression Techniques for an Implant-Supported Prosthesis T2 - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AN - 40980966; 4877943 JF - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AU - Del'acqua, M A AU - Chavez, A M AU - Mollo-Junior, F.D.A. AU - Compagnoni, M A AU - Nogueira, S S AU - Arioli-Filho, J N Y1 - 2008/07/02/ PY - 2008 DA - 2008 Jul 02 KW - Face KW - Maxilla UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40980966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.atitle=Accuracy+of+Impression+Techniques+for+an+Implant-Supported+Prosthesis&rft.au=Del%27acqua%2C+M+A%3BChavez%2C+A+M%3BMollo-Junior%2C+F.D.A.%3BCompagnoni%2C+M+A%3BNogueira%2C+S+S%3BArioli-Filho%2C+J+N&rft.aulast=Del%27acqua&rft.aufirst=M&rft.date=2008-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2008Toronto/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy of the Index and Three Techniques for Abutment Impressions T2 - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AN - 40974047; 4877944 JF - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AU - Chavez, A M AU - Mollo, F.D.A. AU - Nogueira, S S AU - Filho, J.N. Arioli AU - Del'acqua, M A Y1 - 2008/07/02/ PY - 2008 DA - 2008 Jul 02 KW - Face KW - Maxilla UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40974047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.atitle=Accuracy+of+the+Index+and+Three+Techniques+for+Abutment+Impressions&rft.au=Chavez%2C+A+M%3BMollo%2C+F.D.A.%3BNogueira%2C+S+S%3BFilho%2C+J.N.+Arioli%3BDel%27acqua%2C+M+A&rft.aulast=Chavez&rft.aufirst=A&rft.date=2008-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2008Toronto/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Human Salivary Gland Stem/Progenitor Cells (SGSC) T2 - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AN - 40973057; 4878062 JF - 86th General Session and Exhibition of the International Association for Dental Research and 32nd Annual Meeting of the American Association for Dental Research AU - Yoshizawa, S AU - Mineshiba, J AU - Weigert, R AU - Aye, M P AU - Robey, P G Y1 - 2008/07/02/ PY - 2008 DA - 2008 Jul 02 KW - Salivary gland KW - Stem cells KW - Glands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40973057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.atitle=Characterization+of+Human+Salivary+Gland+Stem%2FProgenitor+Cells+%28SGSC%29&rft.au=Yoshizawa%2C+S%3BMineshiba%2C+J%3BWeigert%2C+R%3BAye%2C+M+P%3BRobey%2C+P+G&rft.aulast=Yoshizawa&rft.aufirst=S&rft.date=2008-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2008Toronto/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - What do we know about hearing protector comfort? AN - 85407365; pmid-19052440 AB - The purpose of the present article is to review comfort studies on hearing protector devices. Comfort is probably the most important dimension for long-term worker acceptance and effective wear of hearing protectors in noise. A short digression has been made to introduce comfort work from the textile and clothing industries where models of comfort have been attempted and comfort research is much more sophisticated. Finally, presented are some recent efforts by NIOSH to examine issues of hearing protector comfort in greater detail. These efforts include a field study of a semi-custom earplug hearing protector. JF - Noise & health AU - Davis, Rickie R AD - Hearing Loss Prevention Team, Engineering and Physical Hazards Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. rrd1@cdc.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 83 EP - 89 VL - 10 IS - 40 SN - 1463-1741, 1463-1741 KW - Index Medicus KW - National Library of Medicine KW - Consumer Satisfaction KW - *Ear Protective Devices: standards KW - Equipment Design KW - *Hearing Loss, Noise-Induced: prevention & control KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Health KW - United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85407365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+%26+health&rft.atitle=What+do+we+know+about+hearing+protector+comfort%3F&rft.au=Davis%2C+Rickie+R&rft.aulast=Davis&rft.aufirst=Rickie&rft.date=2008-07-01&rft.volume=10&rft.issue=40&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Noise+%26+health&rft.issn=14631741&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The National Institute for Occupational Safety and Health Radiation Dose Reconstruction Program: commentary and conclusions. AN - 71661765; 18545038 JF - Health physics AU - Neton, James W AU - Elliott, Larry J AD - National Institute for Occupational Safety and Health, Office of Compensation Analysis and Support, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA. jneton@cdc.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 160 EP - 163 VL - 95 IS - 1 KW - Radioactive Pollutants KW - 0 KW - Index Medicus KW - United States KW - Reproducibility of Results KW - Risk Factors KW - Humans KW - Workers' Compensation KW - Data Collection KW - Quality Control KW - Radiation Injuries KW - Occupational Health -- legislation & jurisprudence KW - Radiation Dosage KW - Occupational Exposure -- prevention & control KW - Radiation Monitoring -- methods KW - Occupational Exposure -- standards KW - Occupational Exposure -- adverse effects KW - Radioactive Pollutants -- toxicity KW - Risk Assessment -- methods KW - National Institute for Occupational Safety and Health (U.S.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71661765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=The+National+Institute+for+Occupational+Safety+and+Health+Radiation+Dose+Reconstruction+Program%3A+commentary+and+conclusions.&rft.au=Neton%2C+James+W%3BElliott%2C+Larry+J&rft.aulast=Neton&rft.aufirst=James&rft.date=2008-07-01&rft.volume=95&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=1538-5159&rft_id=info:doi/10.1097%2F01.HP.0000311550.43768.48 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-16 N1 - Date created - 2008-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.HP.0000311550.43768.48 ER - TY - JOUR T1 - Analysis of in vivo mutation data can inform cancer risk assessment. AN - 71652807; 18321622 AB - Under the new U.S. Environmental Protection Agency (EPA) Cancer Risk Assessment Guidelines [U.S. EPA, 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001B, March 2005], the quantitative model chosen for cancer risk assessment is based on the mode-of-action (MOA) of the chemical under consideration. In particular, the risk assessment model depends on whether or not the chemical causes tumors through a direct DNA-reactive mechanism. It is assumed that direct DNA-reactive carcinogens initiate carcinogenesis by inducing mutations and have low-dose linear dose-response curves, whereas carcinogens that operate through a nonmutagenic MOA may have nonlinear dose-responses. We are currently evaluating whether the analysis of in vivo gene mutation data can inform the risk assessment process by better defining the MOA for cancer and thus influencing the choice of the low-dose extrapolation model. This assessment includes both a temporal analysis of mutation induction and a dose-response concordance analysis of mutation with tumor incidence. Our analysis of published data on riddelliine in rats and dichloroacetic acid in mice indicates that our approach has merit. We propose an experimental design and graphical analysis that allow for assessing time-to-mutation and dose-response concordance, thereby optimizing the potential for in vivo mutation data to inform the choice of the quantitative model used in cancer risk assessment. JF - Regulatory toxicology and pharmacology : RTP AU - Moore, Martha M AU - Heflich, Robert H AU - Haber, Lynne T AU - Allen, Bruce C AU - Shipp, Annette M AU - Kodell, Ralph L AD - National Center for Toxicological Research, Food and Drug Administration, Division of Genetic and Reproductive Toxicology, Jefferson, AR 72079, USA. martha.moore@fda.hhs.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 151 EP - 161 VL - 51 IS - 2 SN - 0273-2300, 0273-2300 KW - Carcinogens KW - 0 KW - Mutagens KW - DNA KW - 9007-49-2 KW - Index Medicus KW - United States KW - Animals KW - United States Environmental Protection Agency KW - Dose-Response Relationship, Drug KW - Humans KW - DNA -- metabolism KW - Mutagens -- toxicity KW - Guidelines as Topic KW - Risk Assessment -- methods KW - DNA -- drug effects KW - Mutation -- drug effects KW - Neoplasms -- chemically induced KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71652807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Analysis+of+in+vivo+mutation+data+can+inform+cancer+risk+assessment.&rft.au=Moore%2C+Martha+M%3BHeflich%2C+Robert+H%3BHaber%2C+Lynne+T%3BAllen%2C+Bruce+C%3BShipp%2C+Annette+M%3BKodell%2C+Ralph+L&rft.aulast=Moore&rft.aufirst=Martha&rft.date=2008-07-01&rft.volume=51&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2008.01.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-21 N1 - Date created - 2008-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2008.01.015 ER - TY - JOUR T1 - Alcohol use, injuries, and prenatal visits during three successive pregnancies among American Indian women on the Northern Plains who have children with fetal alcohol syndrome or incomplete fetal alcohol syndrome. AN - 69605547; 18498046 AB - The purpose of the study was to compare three sequential pregnancies of American Indian women who have children with FAS or children with incomplete FAS with women who did not have children with FAS. Two retrospective case-control studies were conducted of Northern Plains American Indian children with fetal alcohol syndrome (FAS) (Study 1) or incomplete FAS (Study 2) in 1981-1993. Three successive pregnancies ending in live births of 43 case mothers who had children with FAS, and 35 case mothers who had children with incomplete FAS were compared to the pregnancies of 86 and 70 control mothers who did not have children with FAS, respectively, in the two studies. Prenatal records were abstracted for the index child (child with FAS or incomplete FAS) and siblings born just before and just after the index child, and comparable prenatal records for the controls. Compared to the controls, significantly more case mothers used alcohol before and after all three pregnancies and during pregnancy with the before sibling and the index child. Mothers who had children with FAS reduced their alcohol use during the pregnancy following the birth of the index child. All Study 1 case mothers (100%) and 60% of Study 2 case mothers used alcohol during the pregnancy with the index child compared to 20 and 9% of respective control mothers. More study 1 case mothers experienced unintentional injuries (OR 9.50) and intentional injuries during the index pregnancy (OR 9.33) than the control mothers. Most case mothers began prenatal care in the second trimester. Alcohol use was documented before, during and after each of the three pregnancies. Women of child-bearing age should be screened for alcohol use whenever they present for medical services. Mothers who had a child with FAS decreased their alcohol consumption with the next pregnancy, a finding that supports the importance of prenatal screening throughout pregnancy. Women who receive medical care for injuries should be screened for alcohol use and referred for appropriate treatment. Protective custody, case management and treatment services need to be readily available for women who use alcohol. JF - Maternal and child health journal AU - Kvigne, Valborg L AU - Leonardson, Gary R AU - Borzelleca, Joseph AU - Brock, Ellen AU - Neff-Smith, Martha AU - Welty, Thomas K AD - Aberdeen Area Indian Health Service, 2013 W 15th St #1, Sioux Falls, SD 57104, USA. kvig6@aol.com Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 37 EP - 45 VL - 12 Suppl 1 KW - Index Medicus KW - Odds Ratio KW - Humans KW - Montana -- epidemiology KW - Adult KW - Retrospective Studies KW - Case-Control Studies KW - South Dakota -- epidemiology KW - Confidence Intervals KW - Middle Aged KW - Female KW - Pregnancy KW - Prenatal Care -- statistics & numerical data KW - Indians, North American -- statistics & numerical data KW - Alcohol Drinking -- epidemiology KW - Fetal Alcohol Spectrum Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69605547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maternal+and+child+health+journal&rft.atitle=Alcohol+use%2C+injuries%2C+and+prenatal+visits+during+three+successive+pregnancies+among+American+Indian+women+on+the+Northern+Plains+who+have+children+with+fetal+alcohol+syndrome+or+incomplete+fetal+alcohol+syndrome.&rft.au=Kvigne%2C+Valborg+L%3BLeonardson%2C+Gary+R%3BBorzelleca%2C+Joseph%3BBrock%2C+Ellen%3BNeff-Smith%2C+Martha%3BWelty%2C+Thomas+K&rft.aulast=Kvigne&rft.aufirst=Valborg&rft.date=2008-07-01&rft.volume=12+Suppl+1&rft.issue=&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Maternal+and+child+health+journal&rft.issn=1573-6628&rft_id=info:doi/10.1007%2Fs10995-008-0367-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-05 N1 - Date created - 2008-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10995-008-0367-8 ER - TY - JOUR T1 - Early communication about an ongoing safety review Botox and Botox Cosmetic (botulinum toxin type A) and Myobloc (botulinum toxin type B). AN - 69554305; 18794742 JF - Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses AU - U.S. Food and Drug Administration AD - U.S. Food and Drug Administration PY - 2008 SP - 150 EP - 151 VL - 28 IS - 3 SN - 0741-5206, 0741-5206 KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - Metalloendopeptidases KW - EC 3.4.24.- KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Nursing KW - United States KW - United States Food and Drug Administration KW - Humans KW - Product Surveillance, Postmarketing KW - Drug Labeling KW - Botulinum Toxins, Type A -- adverse effects KW - Botulinum Toxins -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69554305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plastic+surgical+nursing+%3A+official+journal+of+the+American+Society+of+Plastic+and+Reconstructive+Surgical+Nurses&rft.atitle=Early+communication+about+an+ongoing+safety+review+Botox+and+Botox+Cosmetic+%28botulinum+toxin+type+A%29+and+Myobloc+%28botulinum+toxin+type+B%29.&rft.au=U.S.+Food+and+Drug+Administration&rft.aulast=U.S.+Food+and+Drug+Administration&rft.aufirst=&rft.date=2008-07-01&rft.volume=28&rft.issue=3&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Plastic+surgical+nursing+%3A+official+journal+of+the+American+Society+of+Plastic+and+Reconstructive+Surgical+Nurses&rft.issn=07415206&rft_id=info:doi/10.1097%2F01.PSN.0000335818.00036.c5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-30 N1 - Date created - 2008-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.PSN.0000335818.00036.c5 ER - TY - JOUR T1 - Asbestosis mortality surveillance in the United States, 1970-2004. AN - 69404549; 18686715 AB - To describe the demographic, geographic, and occupational distribution of asbestosis mortality in the United States during 1970-2004, we identified a total of 25,413 asbestosis deaths. We calculated national, state, and county death rates, age-adjusted to the 2000 U.S. standard population. We also calculated industry- and occupation-specific proportionate mortality ratios (PMRs), adjusted for age, sex, and race, and corresponding confidence intervals (CIs) using available data. The overall U.S. age-adjusted asbestosis death rate was 4.1 per million population per year; the rate for males (10.4) was nearly 35-fold higher than that for females (0.3). It increased significantly from 0.6 to 6.9 per million population from 1970 to 2000 (p<0.001), and then declined to 6.3 in 2004 (p=0.014). High asbestosis death rates occurred predominantly, though not exclusively, in coastal areas. Industries with highest PMRs included ship and boat building and repairing (18.5; 95% CI 16.3-20.9) and miscellaneous nonmetallic mineral and stone products (15.9; 95% CI 13.0-19.5). Occupations with highest PMRs included insulation workers (109.2; 95% CI 93.8-127.2) and boilermakers (21.3; 95% CI 17.0-26.6). JF - International journal of occupational and environmental health AU - Bang, Ki Moon AU - Mazurek, Jacek M AU - Syamlal, Girija AU - Wood, John M AD - Division of Respiratory Disease Studies, RM H-G900.2, National Institute for Occupational Safety and Health, CDC, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA. kmb2@cdc.gov PY - 2008 SP - 161 EP - 169 VL - 14 IS - 3 SN - 1077-3525, 1077-3525 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Occupations KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Population Surveillance KW - Asbestosis -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69404549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+and+environmental+health&rft.atitle=Asbestosis+mortality+surveillance+in+the+United+States%2C+1970-2004.&rft.au=Bang%2C+Ki+Moon%3BMazurek%2C+Jacek+M%3BSyamlal%2C+Girija%3BWood%2C+John+M&rft.aulast=Bang&rft.aufirst=Ki&rft.date=2008-07-01&rft.volume=14&rft.issue=3&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+and+environmental+health&rft.issn=10773525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-02 N1 - Date created - 2008-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monitoring of brevetoxins in the Karenia brevis bloom-exposed Eastern oyster (Crassostrea virginica). AN - 69377498; 18582486 AB - Brevetoxin uptake and elimination were examined in Eastern oyster (Crassostrea virginica) exposed to recurring blooms of the marine alga Karenia brevis in Sarasota Bay, FL, over a three-year period. Brevetoxins were monitored by in vitro assays (ELISA, cytotoxicity assay, and receptor binding assay) and LC-MS, with in vivo toxicity of shellfish extracts assessed by the traditional mouse bioassay. Measurements by all methods reflected well the progression and magnitude of the blooms. Highest levels recorded by mouse bioassay at bloom peak were 157 MU/100g. Oysters were toxic by mouse bioassay at levels >or=20 MU/100g for up to two weeks after bloom dissipation, whereas brevetoxins were measurable by in vitro assays and LC-MS for several months afterwards. For the structure-based methods, summed values for the principal brevetoxin metabolites of PbTx-2 (cysteine and cysteine sulfoxide conjugates), as determined by LC-MS, were highly correlated (r(2)=0.90) with composite toxin measurements by ELISA. ELISA and LC-MS values also correlated well (r(2)=0.74 and 0.73, respectively) with those of mouse bioassay. Pharmacology-based cytotoxicity and receptor binding assays did not correlate as well (r(2)=0.65), and were weakly correlated with mouse bioassay (r(2)=0.48 and 0.50, respectively). ELISA and LC-MS methods offer rapid screening and confirmation, respectively, of brevetoxin contamination in the oyster, and are excellent alternatives to mouse bioassay for assessing oyster toxicity following K. brevis blooms. JF - Toxicon : official journal of the International Society on Toxinology AU - Plakas, Steven M AU - Jester, Edward L E AU - El Said, Kathleen R AU - Granade, Hudson R AU - Abraham, Ann AU - Dickey, Robert W AU - Scott, Paula S AU - Flewelling, Leanne J AU - Henry, Michael AU - Blum, Patricia AU - Pierce, Richard AD - Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, 1 Iberville Drive, Dauphin Island, AL 36528, USA. steven.plakas@fda.hhs.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 32 EP - 38 VL - 52 IS - 1 SN - 0041-0101, 0041-0101 KW - Marine Toxins KW - 0 KW - Oxocins KW - brevetoxin KW - 98225-48-0 KW - Index Medicus KW - Mass Spectrometry KW - Animals KW - Food Contamination KW - Chromatography, Liquid KW - Biological Assay KW - Mice KW - Environmental Monitoring KW - Marine Toxins -- analysis KW - Oxocins -- analysis KW - Dinoflagellida -- pathogenicity KW - Crassostrea -- metabolism KW - Oxocins -- toxicity KW - Marine Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69377498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Monitoring+of+brevetoxins+in+the+Karenia+brevis+bloom-exposed+Eastern+oyster+%28Crassostrea+virginica%29.&rft.au=Plakas%2C+Steven+M%3BJester%2C+Edward+L+E%3BEl+Said%2C+Kathleen+R%3BGranade%2C+Hudson+R%3BAbraham%2C+Ann%3BDickey%2C+Robert+W%3BScott%2C+Paula+S%3BFlewelling%2C+Leanne+J%3BHenry%2C+Michael%3BBlum%2C+Patricia%3BPierce%2C+Richard&rft.aulast=Plakas&rft.aufirst=Steven&rft.date=2008-07-01&rft.volume=52&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2008.04.174 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-16 N1 - Date created - 2008-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxicon.2008.04.174 ER - TY - JOUR T1 - Mold(2), molecular descriptors from 2D structures for chemoinformatics and toxicoinformatics. AN - 69362851; 18564836 AB - Research applications in chemoinformatics and toxicoinformatics increasingly use representations of molecules in the form of numerical descriptors that capture the structural characteristics and properties of molecules. These representations are useful for ADME/toxicity prediction, diversity analysis, library design, QSAR/QSPR, virtual screening, and other purposes. Molecular descriptors have ranged from relatively simple forms calculated from simple two-dimensional (2D) chemical structures to more complex forms representing three-dimensional (3D) chemical structures or complex molecular fingerprints consisting of numerous bit positions to represent specific chemical information. The Mold (2) software was developed to enable the rapid calculation of a large and diverse set of descriptors encoding two-dimensional chemical structure information. Comparative analysis of Mold (2) descriptors with those calculated by Cerius (2), Dragon, and Molconn-Z on several data sets using Shannon entropy analysis demonstrated that Mold (2) descriptors convey a similar amount of information. In addition, using the same classification method, slightly better models were generated using Mold (2) descriptors compared to those generated using descriptors from the compared commercial software packages. The low computing cost for Mold (2) makes it suitable not only for small data sets, such as in QSAR, but also for large databases in virtual screening. High reproducibility and reliability are expected because Mold (2) does not require 3D structures. Mold (2) is freely available to the public ( http://www.fda.gov/nctr/science/centers/toxicoinformatics/index.htm). JF - Journal of chemical information and modeling AU - Hong, Huixiao AU - Xie, Qian AU - Ge, Weigong AU - Qian, Feng AU - Fang, Hong AU - Shi, Leming AU - Su, Zhenqiang AU - Perkins, Roger AU - Tong, Weida AD - Center for Toxicoinformatics, Division of Systems Toxicology, National Center for Toxicological Research, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. huixiao.hong@fda.hhs.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 1337 EP - 1344 VL - 48 IS - 7 SN - 1549-9596, 1549-9596 KW - Index Medicus KW - Molecular Structure KW - Quantitative Structure-Activity Relationship KW - Information Systems KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69362851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemical+information+and+modeling&rft.atitle=Mold%282%29%2C+molecular+descriptors+from+2D+structures+for+chemoinformatics+and+toxicoinformatics.&rft.au=Hong%2C+Huixiao%3BXie%2C+Qian%3BGe%2C+Weigong%3BQian%2C+Feng%3BFang%2C+Hong%3BShi%2C+Leming%3BSu%2C+Zhenqiang%3BPerkins%2C+Roger%3BTong%2C+Weida&rft.aulast=Hong&rft.aufirst=Huixiao&rft.date=2008-07-01&rft.volume=48&rft.issue=7&rft.spage=1337&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemical+information+and+modeling&rft.issn=15499596&rft_id=info:doi/10.1021%2Fci800038f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-11 N1 - Date created - 2008-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ci800038f ER - TY - JOUR T1 - Activation of Nrf2 in defense against cadmium-induced oxidative stress. AN - 69328170; 18512965 AB - Exposure to cadmium (Cd) elicits a range of adverse responses including oxidative damage and cancer. The molecular targets of Cd remain largely unidentified. Here, we analyzed the function and signal transduction of transcription factor Nrf2 in protection against Cd-induced oxidative stress. Wild-type (Nrf2 (+/+)) mouse embryonic fibroblasts (MEF) produced reactive oxygen species (ROS) at a low level, whereas treatment with Cd significantly increased the ROS production. On the other hand, Nrf2 knockout (Nrf2 (-/-)) MEF cells exhibited an elevated level of ROS under a basal condition, and Cd dramatically increased the ROS production at concentrations as low as 2 microM, resulting in increased sensitivity to Cd-induced cell death. Cd induced the basal and inducible expression of cytoprotective enzymes NQO1 and HO1 in WT MEF cells, but induction was lost in Nrf2 (-/-) MEF cells. Induction of the genes required antioxidant response elements (ARE) as Cd drove ARE-dependent reporter expression and Cd-activated Nrf2 bound to endogenous AREs in mouse hepa1c1c7 cells. Activation of Nrf2 by Cd involved stabilization of the Nrf2 protein, increased formation of Nrf2/Keap1 complex in the cytoplasm, translocation of the complex into the nucleus, and subsequently disruption of the complex. Lastly, Nrf2 was found ubiquitinated in the cytoplasm but deubiquitinated in the nucleus. The study provided a mechanistic transcriptional model in which Cd activates Nrf2 through a metal-activated signaling pathway involving a dynamic interplay between ubiquitination/deubiquitination and complex formation/dissociation of Nrf2 and Keap1. JF - Chemical research in toxicology AU - He, Xiaoqing AU - Chen, Michael G AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 1375 EP - 1383 VL - 21 IS - 7 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Cytoskeletal Proteins KW - Environmental Pollutants KW - Keap1 protein, mouse KW - Kelch-Like ECH-Associated Protein 1 KW - Membrane Proteins KW - NF-E2-Related Factor 2 KW - Nfe2l2 protein, mouse KW - Reactive Oxygen Species KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Hmox1 protein, mouse KW - NAD(P)H Dehydrogenase (Quinone) KW - EC 1.6.5.2 KW - Nqo1 protein, mouse KW - NADPH Dehydrogenase KW - EC 1.6.99.1 KW - Cadmium Chloride KW - J6K4F9V3BA KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Hepatocytes -- drug effects KW - Cell Nucleus -- metabolism KW - Gene Silencing KW - Cell Nucleus -- drug effects KW - Adaptor Proteins, Signal Transducing -- biosynthesis KW - Membrane Proteins -- genetics KW - Mice, Knockout KW - Cytoskeletal Proteins -- biosynthesis KW - Cell Survival -- drug effects KW - Membrane Proteins -- biosynthesis KW - Signal Transduction KW - Cytoskeletal Proteins -- genetics KW - Fibroblasts -- drug effects KW - Heme Oxygenase-1 -- biosynthesis KW - NADPH Dehydrogenase -- genetics KW - Dose-Response Relationship, Drug KW - Cell Line, Tumor KW - Heme Oxygenase-1 -- genetics KW - Mice KW - Fibroblasts -- metabolism KW - Cells, Cultured KW - Adaptor Proteins, Signal Transducing -- genetics KW - NADPH Dehydrogenase -- biosynthesis KW - Hepatocytes -- metabolism KW - Transcription, Genetic -- drug effects KW - Environmental Pollutants -- toxicity KW - NF-E2-Related Factor 2 -- genetics KW - Cadmium Chloride -- toxicity KW - Oxidative Stress -- drug effects KW - NF-E2-Related Factor 2 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69328170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Activation+of+Nrf2+in+defense+against+cadmium-induced+oxidative+stress.&rft.au=He%2C+Xiaoqing%3BChen%2C+Michael+G%3BMa%2C+Qiang&rft.aulast=He&rft.aufirst=Xiaoqing&rft.date=2008-07-01&rft.volume=21&rft.issue=7&rft.spage=1375&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx800019a LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-11 N1 - Date created - 2008-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx800019a ER - TY - JOUR T1 - Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture. AN - 69306869; 18456338 AB - Ketamine, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, is used as a pediatric anesthetic for surgical procedures. Recent data suggest that anesthetic drugs may cause neurodegeneration during development. The purpose of this study was to determine the dose and temporal response of ketamine using newborn rat forebrain cultures and also to determine if co-administration of 7-nitroindazole, a nitric oxide synthase (NOS) inhibitor, could protect or reverse ketamine-induced cell death. Neural cells collected from the rat forebrain were incubated for 24h with 1, 10 or 20 microM ketamine alone or with ketamine plus 1, 5, 10 or 20 microM 7-nitroindazole. Ketamine (10 microM) caused an increase in DNA fragmentation and elevated immunoreactivity to nitrotyrosine, a marked reduction in the expression of the neuronal marker polysialic acid neural cell adhesion molecule (PSA-NCAM) and in mitochondrial metabolism, as well as an increased Bax/BCL-XL ratio. No significant effect was observed in the release of lactate dehydrogenase (LDH). Ketamine-induced neurotoxic effects were effectively blocked by 7-nitroindazole (10 microM). These data indicate a role for nitric oxide in the enhanced degeneration induced by ketamine in vitro and also suggest that blocking neuronal nitric oxide synthase (nNOS) may help reduce the risk of ketamine in pediatrics. JF - Neurotoxicology AU - Wang, Cheng AU - Sadovova, Natalya AU - Patterson, Tucker A AU - Zou, Xiaoju AU - Fu, Xin AU - Hanig, Joseph P AU - Paule, Merle G AU - Ali, Syed F AU - Zhang, Xuan AU - Slikker, William AD - Division of Neurotoxicology, National Center for Toxicological Research/US Food & Drug Administration, HFT-132 Jefferson, AR, USA. cheng.wang@fda.hhs.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 613 EP - 620 VL - 29 IS - 4 SN - 0161-813X, 0161-813X KW - Excitatory Amino Acid Antagonists KW - 0 KW - Indazoles KW - Neural Cell Adhesion Molecule L1 KW - Neuroprotective Agents KW - Sialic Acids KW - Tetrazolium Salts KW - Thiazoles KW - bcl-2-Associated X Protein KW - bcl-X Protein KW - polysialyl neural cell adhesion molecule KW - Ketamine KW - 690G0D6V8H KW - Nitric Oxide Synthase Type I KW - EC 1.14.13.39 KW - Hydro-Lyases KW - EC 4.2.1.- KW - lactate dehydratase KW - EC 4.2.1.54 KW - thiazolyl blue KW - EUY85H477I KW - 7-nitroindazole KW - UX0N37CMVH KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Ketamine -- toxicity KW - Neural Cell Adhesion Molecule L1 -- metabolism KW - Sialic Acids -- metabolism KW - bcl-X Protein -- metabolism KW - bcl-2-Associated X Protein -- metabolism KW - Rats KW - Animals, Newborn KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Nitric Oxide Synthase Type I -- metabolism KW - DNA Fragmentation -- drug effects KW - Gene Expression Regulation -- drug effects KW - Time Factors KW - Hydro-Lyases -- metabolism KW - Excitatory Amino Acid Antagonists -- toxicity KW - Neurons -- drug effects KW - Indazoles -- pharmacology KW - Prosencephalon -- cytology KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69306869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Protective+effects+of+7-nitroindazole+on+ketamine-induced+neurotoxicity+in+rat+forebrain+culture.&rft.au=Wang%2C+Cheng%3BSadovova%2C+Natalya%3BPatterson%2C+Tucker+A%3BZou%2C+Xiaoju%3BFu%2C+Xin%3BHanig%2C+Joseph+P%3BPaule%2C+Merle+G%3BAli%2C+Syed+F%3BZhang%2C+Xuan%3BSlikker%2C+William&rft.aulast=Wang&rft.aufirst=Cheng&rft.date=2008-07-01&rft.volume=29&rft.issue=4&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2008.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-05 N1 - Date created - 2008-07-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuro.2008.03.007 ER - TY - JOUR T1 - An innovative approach to determine fetal risk: the FDA Office of Women's Health pregnancy exposure registry web listing. AN - 69280625; 18468921 JF - Women's health issues : official publication of the Jacobs Institute of Women's Health AU - Sharma, Pellavi AU - Parekh, Ameeta AU - Uhl, Kathleen AD - Food and Drug Administration, Office of Women's Health, Rockville, Maryland, USA. pellavi.sharma@fda.hhs.gov PY - 2008 SP - 226 EP - 228 VL - 18 IS - 4 SN - 1049-3867, 1049-3867 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Maternal Exposure -- prevention & control KW - Prenatal Care -- legislation & jurisprudence KW - Humans KW - Adult KW - Health Policy KW - Female KW - Pregnancy KW - Registries KW - Internet -- legislation & jurisprudence KW - Prenatal Exposure Delayed Effects -- prevention & control KW - Prenatal Diagnosis -- methods KW - Abnormalities, Drug-Induced -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69280625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+health+issues+%3A+official+publication+of+the+Jacobs+Institute+of+Women%27s+Health&rft.atitle=An+innovative+approach+to+determine+fetal+risk%3A+the+FDA+Office+of+Women%27s+Health+pregnancy+exposure+registry+web+listing.&rft.au=Sharma%2C+Pellavi%3BParekh%2C+Ameeta%3BUhl%2C+Kathleen&rft.aulast=Sharma&rft.aufirst=Pellavi&rft.date=2008-07-01&rft.volume=18&rft.issue=4&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Women%27s+health+issues+%3A+official+publication+of+the+Jacobs+Institute+of+Women%27s+Health&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2008.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-17 N1 - Date created - 2008-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.whi.2008.02.006 ER - TY - JOUR T1 - Cocaine-like neurochemical effects of antihistaminic medications. AN - 69278954; 18363822 AB - The pattern of activation of dopamine (DA) neurotransmission in the nucleus accumbens (NAc) of rats produced by H(1) histamine antagonists which have behavioral effects like those of psychostimulant drugs was examined. Diphenhydramine and (+)-chlorpheniramine were compared with triprolidine, a potent and selective H(1) antagonist and (-)-chlorpheniramine which is less active than its enantiomer at H(1) receptors. Affinities of the drugs to DA, serotonin, and norepinephrine transporters at H(1) receptors and potencies for DA uptake inhibition in striatal synaptosomes were determined to assess mechanisms by which the compounds increased DA levels. Intravenous diphenhydramine (1.0-3.0 mg/kg) (+)- and (-)-chlorpheniramine (1.0-5.6 mg/kg) but not triprolidine (1.0-3.0 mg/kg) elicited a cocaine-like pattern of stimulation of DA transmission with larger effects in the NAc shell than core. The absence of stereospecific effects with chlorpheniramine enantiomers along with the lack of an effect with triprolidine suggest that the effects on DA transmission were not related to H(1) receptor antagonism. Although in vivo potencies were not directly related to DA transporter affinities, it is hypothesized that actions at that site modulated by other actions, possibly those at the serotonin transporter, are primarily responsible for the neurochemical actions of the drugs on DA neurotransmission and might underlie the occasional misuse of these medications. JF - Journal of neurochemistry AU - Tanda, Gianluigi AU - Kopajtic, Theresa A AU - Katz, Jonathan L AD - Psychobiology Section, Medications Discovery Research Branch, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. gtanda@intra.nida.nih.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 147 EP - 157 VL - 106 IS - 1 KW - Central Nervous System Stimulants KW - 0 KW - Dopamine Agonists KW - Dopamine Plasma Membrane Transport Proteins KW - Dopamine Uptake Inhibitors KW - Histamine H1 Antagonists KW - Serotonin Plasma Membrane Transport Proteins KW - Triprolidine KW - 2L8T9S52QM KW - Chlorpheniramine KW - 3U6IO1965U KW - Diphenhydramine KW - 8GTS82S83M KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Stereoisomerism KW - Synaptosomes -- drug effects KW - Serotonin Plasma Membrane Transport Proteins -- drug effects KW - Triprolidine -- pharmacology KW - Presynaptic Terminals -- metabolism KW - Rats KW - Presynaptic Terminals -- drug effects KW - Reward KW - Substance-Related Disorders -- metabolism KW - Dopamine Plasma Membrane Transport Proteins -- drug effects KW - Male KW - Dopamine Uptake Inhibitors -- agonists KW - Substance-Related Disorders -- physiopathology KW - Serotonin Plasma Membrane Transport Proteins -- metabolism KW - Synaptic Transmission -- drug effects KW - Chlorpheniramine -- pharmacology KW - Triprolidine -- adverse effects KW - Synaptic Transmission -- physiology KW - Rats, Sprague-Dawley KW - Chlorpheniramine -- adverse effects KW - Diphenhydramine -- pharmacology KW - Dopamine Plasma Membrane Transport Proteins -- metabolism KW - Diphenhydramine -- adverse effects KW - Synaptosomes -- metabolism KW - Central Nervous System Stimulants -- pharmacology KW - Nucleus Accumbens -- drug effects KW - Dopamine Agonists -- pharmacology KW - Histamine H1 Antagonists -- pharmacology KW - Cocaine -- agonists KW - Nucleus Accumbens -- metabolism KW - Histamine H1 Antagonists -- adverse effects KW - Dopamine Agonists -- adverse effects KW - Dopamine -- metabolism KW - Central Nervous System Stimulants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69278954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Trans+Fat+Labeling+and+Regulations&rft.au=Moss%2C+J&rft.aulast=Moss&rft.aufirst=J&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-19 N1 - Date created - 2008-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1471-4159.2008.05361.x ER - TY - JOUR T1 - Tumor necrosis factor p55 and p75 receptors are involved in chemical-induced apoptosis of dentate granule neurons. AN - 69277301; 18373618 AB - Localized tumor necrosis factor-alpha (TNFalpha) elevation has diverse effects in brain injury often attributed to signaling via TNFp55 or TNFp75 receptors. Both dentate granule cells and CA pyramidal cells express TNF receptors (TNFR) at low levels in a punctate pattern. Using a model to induce selective death of dentate granule cells (trimethyltin; 2 mg/kg, i.p.), neuronal apoptosis [terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ end labeling, active caspase 3 (AC3)] was accompanied by amoeboid microglia and elevated TNFalpha mRNA levels. TNFp55R (55 kDa type-1 TNFR) and TNFp75R (75 kDa type-2 TNFR) immunoreactivity in AC3(+) neurons displayed a pattern suggestive of receptor internalization and a temporal sequence of expression of TNFp55R followed by TNFp75R associated with the progression of apoptosis. A distinct ramified microglia response occurred around CA1 neurons and healthy dentate neurons that displayed an increase in the normal punctate pattern of TNFRs. Neuronal damage was decreased with i.c.v. injection of TNFalpha antibody and in TNFp55R-/-p75R-/- mice that showed higher constitutive mRNA levels for interleukin (IL-1alpha), macrophage inflammatory protein 1-alpha (MIP-1alpha), TNFalpha, transforming growth factor beta1, Fas, and TNFRSF6-assoicated via death domain (FADD). TNFp75R-/- mice showed exacerbated injury and elevated mRNA levels for IL-1alpha, MIP-1alpha, and TNFalpha. In TNFp55R-/- mice, constitutive mRNA levels for TNFalpha, IL-6, caspase 8, FADD, and Fas-associated phosphatase were higher; IL-1alpha, MIP-1alpha, and transforming growth factor beta1 lower. The mice displayed exacerbated neuronal death, delayed microglia response, increased FADD and TNFp75R mRNA levels, and co-expression of TNFp75R in AC3(+) neurons. The data demonstrate TNFR-mediated apoptotic death of dentate granule neurons utilizing both TNFRs and suggest a TNFp75R-mediated apoptosis in the absence of normal TNFp55R activity. JF - Journal of neurochemistry AU - Harry, G Jean AU - Lefebvre d'Hellencourt, Christian AU - McPherson, Christopher A AU - Funk, Jason A AU - Aoyama, Mineyoshi AU - Wine, Robert N AD - Department of Health and Human Services, Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. harry@niehs.nih.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 281 EP - 298 VL - 106 IS - 1 KW - Apoptosis Regulatory Proteins KW - 0 KW - Cytokines KW - Fadd protein, mouse KW - Fas-Associated Death Domain Protein KW - Neurotoxins KW - Receptors, Nerve Growth Factor KW - Receptors, Tumor Necrosis Factor KW - Receptors, Tumor Necrosis Factor, Type I KW - TNFRSF16 protein, mouse KW - Trimethyltin Compounds KW - trimethyltin KW - 1631-73-8 KW - Index Medicus KW - Animals KW - Fas-Associated Death Domain Protein -- genetics KW - Cytokines -- drug effects KW - Cytokines -- genetics KW - Apoptosis Regulatory Proteins -- genetics KW - Apoptosis Regulatory Proteins -- drug effects KW - Mice KW - Cytokines -- metabolism KW - Trimethyltin Compounds -- toxicity KW - Neurotoxins -- toxicity KW - Mice, Knockout KW - Microglia -- immunology KW - Apoptosis Regulatory Proteins -- metabolism KW - Mice, Inbred C57BL KW - Endocytosis -- drug effects KW - Fas-Associated Death Domain Protein -- drug effects KW - Fas-Associated Death Domain Protein -- metabolism KW - Microglia -- drug effects KW - Endocytosis -- physiology KW - Male KW - Receptors, Nerve Growth Factor -- genetics KW - Dentate Gyrus -- immunology KW - Neurons -- metabolism KW - Nerve Degeneration -- immunology KW - Neurons -- drug effects KW - Dentate Gyrus -- metabolism KW - Apoptosis -- immunology KW - Nerve Degeneration -- chemically induced KW - Receptors, Tumor Necrosis Factor, Type I -- drug effects KW - Receptors, Tumor Necrosis Factor -- drug effects KW - Receptors, Tumor Necrosis Factor, Type I -- genetics KW - Receptors, Nerve Growth Factor -- metabolism KW - Receptors, Tumor Necrosis Factor, Type I -- metabolism KW - Receptors, Nerve Growth Factor -- drug effects KW - Dentate Gyrus -- pathology KW - Nerve Degeneration -- metabolism KW - Apoptosis -- drug effects KW - Receptors, Tumor Necrosis Factor -- metabolism KW - Neurons -- immunology KW - Receptors, Tumor Necrosis Factor -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69277301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Tumor+necrosis+factor+p55+and+p75+receptors+are+involved+in+chemical-induced+apoptosis+of+dentate+granule+neurons.&rft.au=Harry%2C+G+Jean%3BLefebvre+d%27Hellencourt%2C+Christian%3BMcPherson%2C+Christopher+A%3BFunk%2C+Jason+A%3BAoyama%2C+Mineyoshi%3BWine%2C+Robert+N&rft.aulast=Harry&rft.aufirst=G&rft.date=2008-07-01&rft.volume=106&rft.issue=1&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/10.1111%2Fj.1471-4159.2008.05382.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-19 N1 - Date created - 2008-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1471-4159.2008.05382.x ER - TY - JOUR T1 - Validation of an in vitro model for assessment of androstenedione hepatotoxicity using the rat liver cell line clone-9. AN - 69270142; 18059068 AB - Androstenedione, a naturally occurring steroid hormone, has been used to enhance athletic performance. Little is known, however, about its hepatotoxicity. Clone-9 cells, a non-transformed epithelial cell line that was originally isolated from normal liver of a 4-week old Sprague-Dawley rat, were used as an in vitro model to assess the hepatotoxic potential of androstenedione. The cultures were treated with androstenedione for 24 h at 37 degrees C in 5% CO(2) at concentrations of 0-100 microg ml(-1). After the treatment period, the cells and the culture supernatants were assayed for markers of cytotoxicity which included: release of liver enzymes, cell viability, cellular double-stranded DNA content, oxidative stress, steatosis, cellular ATP content, caspase-3 activity, the mitochondrial permeability transition and induction of cytochrome P450 activity. Significant concentration-dependent differences from control were observed in some endpoints at medium concentrations of 10 microg ml(-1) and above. These in vitro findings were compared with comparable endpoints obtained from an in vivo study of androstenedione toxicity in female Sprague-Dawley rats. Of the eight endpoints that could be compared between the two studies, only three (lipid accumulation, ATP depletion and P450 activity) appeared to be concordant. This suggests that, under the experimental conditions used, the clone-9 cells were not a good model for androstenedione hepatotoxicity. JF - Journal of applied toxicology : JAT AU - Sahu, Saura C AU - Wiesenfeld, Paddy L AU - Kim, Chung S AU - Ross, Ivan A AU - Sapienza, Philip P AU - Newell, Richard AU - O'Donnell, Michael W AU - Flynn, Thomas J AD - Division of Toxicology, Office of Applied Research and Safety Assessment, U. S. Food and Drug Administration, Laurel, MD 20708, USA. saura.sahu@fda.hhs.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 703 EP - 709 VL - 28 IS - 5 SN - 0260-437X, 0260-437X KW - Biomarkers KW - 0 KW - Enzymes KW - Androstenedione KW - 409J2J96VR KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - DNA KW - 9007-49-2 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Clone Cells KW - Animals KW - Liver -- pathology KW - Liver -- cytology KW - Hepatocytes -- drug effects KW - Reproducibility of Results KW - Enzymes -- metabolism KW - Hepatocytes -- enzymology KW - Models, Biological KW - DNA -- biosynthesis KW - Rats KW - Rats, Sprague-Dawley KW - Enzymes -- blood KW - Liver -- drug effects KW - Adenosine Triphosphate -- metabolism KW - DNA -- genetics KW - Oxidative Stress -- drug effects KW - Cell Line KW - Female KW - Caspase 3 -- metabolism KW - Chemical and Drug Induced Liver Injury -- pathology KW - Androstenedione -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69270142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Validation+of+an+in+vitro+model+for+assessment+of+androstenedione+hepatotoxicity+using+the+rat+liver+cell+line+clone-9.&rft.au=Sahu%2C+Saura+C%3BWiesenfeld%2C+Paddy+L%3BKim%2C+Chung+S%3BRoss%2C+Ivan+A%3BSapienza%2C+Philip+P%3BNewell%2C+Richard%3BO%27Donnell%2C+Michael+W%3BFlynn%2C+Thomas+J&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2008-07-01&rft.volume=28&rft.issue=5&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-18 N1 - Date created - 2008-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Age-related differences in susceptibility to toxic effects of valproic acid in rats. AN - 69266982; 17994530 AB - A multi-age rat model was evaluated as a means to identify a potential age-related difference in liver injury following exposure to valproic acid (VPA), a known pediatric hepatotoxic agent. Different age groups of Sprague-Dawley (SD) rats (10-, 25-, 40-, 80-day-old) were administered VPA at doses of 160, 320, 500 or 650 mg kg(-1) (i.p.) for 4 days. Animals from all age groups developed toxicity after treatment with VPA; however, the patterns of toxicity were dissimilar within each age group. The high dose of VPA caused significant lethality in 10- and 25-day-old rats. All doses of VPA caused decrease in the platelet counts (10-, 25-day-old rats) and the rate of growth (40-day-old rats) and increases in the urine creatine concentration (high dose, 80-day-old rats). VPA induced hepatic and splenic alterations in all age groups. The most severe lesions were found mostly in 10- and 80-day-old rats. Significant changes in blood urea nitrogen, alanine aminotransferase and alkaline phosphatase were observed in 10-day-old pups after treatment with low doses of VPA. The highest VPA dose caused significant decreases in the levels of serum total protein (40- and 80-day-old rats). Principal component analysis of spectra derived from terminal urine samples of all age groups showed that each age group clusters separately. In conclusion, this study showed that the vulnerability profile of each age group was different indicating that a multi-age pediatric animal model is appropriate to assess more completely age-dependent changes in drug toxicity. JF - Journal of applied toxicology : JAT AU - Espandiari, Parvaneh AU - Zhang, Jun AU - Schnackenberg, Laura K AU - Miller, Terry J AU - Knapton, Alan AU - Herman, Eugene H AU - Beger, Richard D AU - Hanig, Joseph P AD - FDA, Center for Drug Evaluation and Research, Silver Spring, MD 20993, USA. parvaneh.espandiari@fda.hhs.gov Y1 - 2008/07// PY - 2008 DA - July 2008 SP - 628 EP - 637 VL - 28 IS - 5 SN - 0260-437X, 0260-437X KW - Anticonvulsants KW - 0 KW - Valproic Acid KW - 614OI1Z5WI KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Animals KW - Blood Chemical Analysis KW - Liver -- pathology KW - Spleen -- pathology KW - Blood Cell Count KW - Magnetic Resonance Spectroscopy KW - Rats KW - Rats, Sprague-Dawley KW - Alanine Transaminase -- blood KW - Liver -- drug effects KW - Body Weight -- drug effects KW - Spleen -- drug effects KW - Female KW - Male KW - Metabolism KW - Organ Size -- drug effects KW - Aging -- physiology KW - Valproic Acid -- toxicity KW - Anticonvulsants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69266982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Age-related+differences+in+susceptibility+to+toxic+effects+of+valproic+acid+in+rats.&rft.au=Espandiari%2C+Parvaneh%3BZhang%2C+Jun%3BSchnackenberg%2C+Laura+K%3BMiller%2C+Terry+J%3BKnapton%2C+Alan%3BHerman%2C+Eugene+H%3BBeger%2C+Richard+D%3BHanig%2C+Joseph+P&rft.aulast=Espandiari&rft.aufirst=Parvaneh&rft.date=2008-07-01&rft.volume=28&rft.issue=5&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-18 N1 - Date created - 2008-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Presence of airborne fibers in tungsten refining and manufacturing processes: preliminary characterization. AN - 69244967; 18569509 AB - In tungsten refining and manufacturing processes, a series of tungsten oxides (WO(X)) are typically formed as intermediates in the production of tungsten powder. Studies in the Swedish tungsten refining and manufacturing industry have shown that intermediate tungsten refining processes can create WO(X) fibers. The purpose of the present study was to identify and provide a preliminary characterization of airborne tungsten-containing fiber dimensions, elemental composition, and concentrations in the U.S. tungsten refining and manufacturing industry. To provide the preliminary characterization, 10 static air samples were collected during the course of normal employee work activities and analyzed using standard fiber sampling and counting methods. Results from transmission electron microscopy analyses conducted indicate that airborne fibers with length > 0.5 microm, diameter > 0.01 microm, and aspect ratio > or = 3:1, with a geometric mean (GM) length of approximately 2.0 microm and GM diameter of approximately 0.25 microm, were present on 9 of the 10 air samples collected. Energy dispersive X-ray spectrometry results indicate that airborne fibers prior to the carburization process consisted primarily of tungsten and oxygen, with other elements being detected in trace quantities. Results from an air sample collected at the carburization process indicated the presence of fibers composed primarily of tungsten with oxygen and carbon, and traces of other elements. Based on National Institute for Occupational Safety and Health standard fiber counting rules, airborne fiber concentrations ranged from below the limit of detection to 0.14 f/cm(3). The calcining process was associated with the highest airborne fiber concentrations. More than 99% (574/578) of the airborne fibers identified had an aerodynamic diameter 0.2 mg/sample) were found on the hands of 61% and 0% of these two groups, respectively, with the highest measured quantity equal to 1.06 mg. Samples from the upper surfaces of automobile motors were generally low to nondetectable (<0.027 mg/sample), while the median value of 0.047 mg/50 cm2(CV = 160%) and up to 0.640 mg were found on the drip pans. JF - Journal of Occupational and Environmental Hygiene AU - Boeniger, Mark AU - Neumeister, Charles AU - Booth-Jones, Angela AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 417 EP - 425 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 7 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - High-performance liquid chromatography KW - polyesters KW - Gasoline KW - Motor vehicles KW - Pyrene KW - corn KW - Oil KW - Workers KW - pyrene KW - Sampling KW - Occupational exposure KW - Environmental hygiene KW - Polycyclic aromatic hydrocarbons KW - Skin KW - Oils KW - Hand KW - Filters KW - Fabrics KW - Liquid chromatography KW - Filter paper KW - Dimethyl sulfoxide KW - polycyclic aromatic hydrocarbons KW - technicians KW - Sampling methods KW - Pans KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19580786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Sampling+and+Analytical+Method+Development+and+Hand+Wipe+Measurements+of+Dermal+Exposures+to+Polycyclic+Aromatic+Hydrocarbons&rft.au=Boeniger%2C+Mark%3BNeumeister%2C+Charles%3BBooth-Jones%2C+Angela&rft.aulast=Boeniger&rft.aufirst=Mark&rft.date=2008-07-01&rft.volume=5&rft.issue=7&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802111319 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Polycyclic aromatic hydrocarbons; polyesters; Skin; Gasoline; Motor vehicles; Oils; Hand; Pyrene; Fabrics; Workers; Dimethyl sulfoxide; Filter paper; Sampling; Pans; Environmental hygiene; Filters; Oil; pyrene; Liquid chromatography; polycyclic aromatic hydrocarbons; technicians; corn; Sampling methods; Occupational exposure DO - http://dx.doi.org/10.1080/15459620802111319 ER - TY - JOUR T1 - Bam32: a novel mediator of Erk activation in T cells AN - 194972669; 18448454 AB - Bam32 (B lymphocyte adapter molecule of 32 kDa) is an adapter protein expressed in some hematopoietic cells including B and T lymphocytes. It was previously shown that Bam32-deficient mice have defects in various aspects of B cell activation including B cell receptor (BCR)-induced Erk activation, BCR-induced proliferation and T-independent antibody responses. In this study, we have examined the role of Bam32 in T cell activation using Bam32-deficient mice. By comparing CD4[sup]+ T cells from lymph nodes of wild-type and Bam32-deficient mice, we found that Bam32 was required for optimal TCR-induced Erk activation, cytokine production, proliferation and actin-mediated spreading of CD4[sup]+ T cells. These results indicate a novel pathway to Erk activation in T cells involving the adapter protein Bam32. JF - International Immunology AU - Sommers, Connie L AU - Gurson, Jordan M AU - Surana, Rishi AU - Barda-saad, Mira AU - Lee, Jan AU - Kishor, Aparna AU - Li, Wenmei AU - Gasser, Adam J AU - Barr, Valarie A AU - Miyaji, Michihiko AU - Love, Paul E AU - Samelson, Lawrence E Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 811 EP - 8 CY - Oxford PB - Oxford Publishing Limited(England) VL - 20 IS - 7 SN - 09538178 KW - Medical Sciences--Allergology And Immunology KW - Actins KW - Adaptor Proteins, Signal Transducing KW - Cytokines KW - Dapp1 protein, mouse KW - Lipoproteins KW - Receptors, Antigen, T-Cell KW - Extracellular Signal-Regulated MAP Kinases KW - Animals KW - Adaptor Proteins, Signal Transducing -- immunology KW - Lipoproteins -- immunology KW - Humans KW - Receptors, Antigen, T-Cell -- metabolism KW - Cytokines -- secretion KW - Jurkat Cells KW - Actins -- immunology KW - Mice KW - Cell Proliferation KW - Mice, Knockout KW - Enzyme Activation -- genetics KW - Lymphocyte Activation -- genetics KW - Lipoproteins -- genetics KW - Actins -- genetics KW - Extracellular Signal-Regulated MAP Kinases -- immunology KW - Mice, Inbred C57BL KW - Adaptor Proteins, Signal Transducing -- genetics KW - Cell Adhesion -- immunology KW - Receptors, Antigen, T-Cell -- genetics KW - Signal Transduction KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Lipoproteins -- metabolism KW - CD4-Positive T-Lymphocytes -- metabolism KW - Extracellular Signal-Regulated MAP Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/194972669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Immunology&rft.atitle=Bam32%3A+a+novel+mediator+of+Erk+activation+in+T+cells&rft.au=Sommers%2C+Connie+L%3BGurson%2C+Jordan+M%3BSurana%2C+Rishi%3BBarda-saad%2C+Mira%3BLee%2C+Jan%3BKishor%2C+Aparna%3BLi%2C+Wenmei%3BGasser%2C+Adam+J%3BBarr%2C+Valarie+A%3BMiyaji%2C+Michihiko%3BLove%2C+Paul+E%3BSamelson%2C+Lawrence+E&rft.aulast=Sommers&rft.aufirst=Connie&rft.date=2008-07-01&rft.volume=20&rft.issue=7&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=International+Immunology&rft.issn=09538178&rft_id=info:doi/10.1093%2Fintimm%2Fdxn039 LA - English DB - ProQuest Central N1 - Copyright - Published by Oxford University Press 2008. N1 - Last updated - 2016-08-27 DO - http://dx.doi.org/10.1093/intimm/dxn039 ER - TY - JOUR T1 - Advancing Personalized Health Care through Health Information Technology: An Update from the American Health Information Community's Personalized Health Care Workgroup AN - 19477058; 8339765 AB - The Personalized Health Care Workgroup of the American Health Information Community was formed to determine what is needed to promote standard reporting and incorporation of medical genetic/genomic tests and family health history data in electronic health records. The Workgroup has examined and clarified a range of issues related to this information, including interoperability standards and requirements for confidentiality, privacy, and security, in the course of developing recommendations to facilitate its capture, storage, transmission, and use in clinical decision support. The Workgroup is one of several appointed by the American Health Information Community to study high-priority issues related to the implementation of interoperable electronic health records in the United States. It is also a component of the U.S. Department of Health and Human Services' Personalized Health Care Initiative, which is designed to create a foundation upon which information technology that supports personalized, predictive, and pre-emptive health care can be built. JF - Journal of the American Medical Informatics Association AU - Glaser, John AU - Henley, Douglas E AU - Downing, Gregory AU - Brinner, Kristin M AD - Partners HealthCare, Boston, MA. American Academy of Family Physicians, Leawood, KS. Personalized Health Care Initiative, United States Department of Health and Human Services, Washington, DC. Personalized Health Care Workgroup, American Health Information Community, United States Department of Health and Human Services, Washington, DC Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 391 EP - 396 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 15 IS - 4 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts KW - genomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19477058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Advancing+Personalized+Health+Care+through+Health+Information+Technology%3A+An+Update+from+the+American+Health+Information+Community%27s+Personalized+Health+Care+Workgroup&rft.au=Glaser%2C+John%3BHenley%2C+Douglas+E%3BDowning%2C+Gregory%3BBrinner%2C+Kristin+M&rft.aulast=Glaser&rft.aufirst=John&rft.date=2008-07-01&rft.volume=15&rft.issue=4&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - genomics ER - TY - JOUR T1 - Radiation dose reconstruction program of the National Institute for Occupational Safety and Health: Overview AN - 19381807; 8552906 AB - Over the past 65 years, hundreds of thousands of workers have been engaged in nuclear weapons-related activities for the U.S. Department of Energy or its predecessor agencies. To date, almost 27,000 such employees (or their survivors) have filed claims under Part B of the Energy Employees Occupational Illness Compensation Program Act of 2000, which provides monetary compensation and medical benefits to energy employees who have developed certain types of cancer that have been determined, under the guidelines of the program, to have resulted from occupational radiation exposure covered under the Act. Although it is difficult to predict the number of cancer claims that will be evaluated under this program, the number could double or triple. In each case, the processing of a claim requires that the National Institute for Occupational Safety and Health reconstruct the radiation dose received by the employee followed by a determination by the U.S. Department of Labor as to whether the employee was "at least as likely as not" to have sustained the cancer as a result of his or her occupational exposure to ionizing radiation. Although some of the dose assessments are straightforward, many are extremely complex due to (1) missing, non-interpretable, or undocumented records; (2) a wide variety of external and internal exposure conditions; and/or (3) highly variable work assignments and work loads. The program objectives are to process claims in an effective, efficient, and timely manner. One of the initial challenges was to develop the necessary infrastructure to meet these objectives. Subsequent challenges included documenting that assessments are fair and scientifically consistent. Ensuring that each claimant receives the "benefit of the doubt" in any cases where the required background information and data are ambiguous or not available is also an important objective. Fortunately, there are some aspects of the processing requirements that have tended to reduce the complexity, two examples being that compensation is based on exposures that occurred during covered employment after a cancer has developed and that the required dose estimates are for individual body organs, not effective doses. Throughout the process, every effort has been made to ensure that the dose assessments have the support of the best available science. JF - Health Physics AU - Neton, J W AU - Howard, J AU - Elliott, L J AD - CDC/NIOSH/OD, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226-1998, USA, jfn2@cdc.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 6 EP - 13 VL - 95 IS - 1 SN - 0017-9078, 0017-9078 KW - Pollution Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - employment KW - Data processing KW - Occupational safety KW - Organs KW - Cancer KW - USA KW - guidelines KW - Energy KW - Reviews KW - Ionizing radiation KW - Economics KW - infrastructure KW - Occupational exposure KW - X 24390:Radioactive Materials KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19381807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Radiation+dose+reconstruction+program+of+the+National+Institute+for+Occupational+Safety+and+Health%3A+Overview&rft.au=Neton%2C+J+W%3BHoward%2C+J%3BElliott%2C+L+J&rft.aulast=Neton&rft.aufirst=J&rft.date=2008-07-01&rft.volume=95&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Ionizing radiation; Reviews; Energy; Occupational exposure; Cancer; employment; guidelines; Economics; Occupational safety; infrastructure; Organs; USA ER - TY - JOUR T1 - Establishing bounding internal dose estimates for thorium activities at Rocky Flats AN - 19380561; 8552913 AB - As part of an evaluation of a Special Exposure Cohort petition filed on behalf of workers at the Rocky Flats Plant, the National Institute for Occupational Safety and Health (NIOSH) was required to demonstrate that bounding values could be established for radiation doses due to the potential intake of all radionuclides present at the facility. The main radioactive elements of interest at Rocky Flats were plutonium and uranium, but much smaller quantities of several other elements, including thorium, were occasionally handled at the site. Bounding potential doses from thorium has proven challenging at other sites due to the early historical difficulty in detecting this element through urinalysis methods and the relatively high internal dose delivered per unit intake. This paper reports the results of NIOSH's investigation of the uses of thorium at Rocky Flats and provides bounding dose reconstructions for these operations. During this investigation, NIOSH reviewed unclassified reports, unclassified extracts of classified materials, material balance and inventory ledgers, monthly progress reports from various groups, and health physics field logbooks, and conducted interviews with former Rocky Flats workers. Thorium operations included: (1) an experimental metal forming project with 240 kg of thorium in 1960; (2) the use of pre-formed parts in weapons mockups; (3) the removal of super(228)Th from super(233)U; (4) numerous analytical procedures involving trace quantities of thorium; and (5) the possible experimental use of thorium as a mold coating compound. The thorium handling operations at Rocky Flats were limited in scope, well-monitored and documented, and potential doses can be bounded. JF - Health Physics AU - Ulsh, BA AU - Rich, B L AU - Chew, M H AU - Morris, R L AU - Sharfi, M AU - Rolfes, M R AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop C-46, Cincinnati, OH 45226, USA, bau6@cdc.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 81 EP - 88 VL - 95 IS - 1 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Historical account KW - Metals KW - Plutonium KW - Radioisotopes KW - Occupational safety KW - Uranium KW - Occupational exposure KW - Thorium KW - material balance KW - Weapons KW - Reviews KW - Coatings UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19380561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Establishing+bounding+internal+dose+estimates+for+thorium+activities+at+Rocky+Flats&rft.au=Ulsh%2C+BA%3BRich%2C+B+L%3BChew%2C+M+H%3BMorris%2C+R+L%3BSharfi%2C+M%3BRolfes%2C+M+R&rft.aulast=Ulsh&rft.aufirst=BA&rft.date=2008-07-01&rft.volume=95&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Thorium; Occupational exposure; Weapons; material balance; Metals; Uranium; Plutonium; Reviews; Coatings; Occupational safety; Historical account; Radioisotopes ER - TY - CPAPER T1 - Determination of Total Trans Fatty Acids by GC and IR for Regulatory Compliance T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41043959; 4894966 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Mossoba, M Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Compliance KW - Fatty acids KW - Guanylate cyclase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41043959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Determination+of+Total+Trans+Fatty+Acids+by+GC+and+IR+for+Regulatory+Compliance&rft.au=Mossoba%2C+M&rft.aulast=Mossoba&rft.aufirst=M&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trans Fat Labeling and Regulations T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41041303; 4894967 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Moss, J Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Food KW - Fats UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41041303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Trans+Fat+Labeling+and+Regulations&rft.au=Moss%2C+J&rft.aulast=Moss&rft.aufirst=J&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What is Natural from an FDA Perspective? T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41040745; 4894701 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Nalubola, R Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41040745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=What+is+Natural+from+an+FDA+Perspective%3F&rft.au=Nalubola%2C+R&rft.aulast=Nalubola&rft.aufirst=R&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using a Rapid Multiplex Real-Time PCR Assay for Simultaneous Detection of Salmonella, Shigella and Escherichia coli o157:h7 in potato salad T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41037512; 4894575 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Lin, W AU - Cheng, C AU - Van, K Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Polymerase chain reaction KW - Anadromous species KW - Nucleotide sequence KW - Solanum tuberosum KW - Escherichia coli KW - Salmonella KW - Shigella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41037512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Using+a+Rapid+Multiplex+Real-Time+PCR+Assay+for+Simultaneous+Detection+of+Salmonella%2C+Shigella+and+Escherichia+coli+o157%3Ah7+in+potato+salad&rft.au=Lin%2C+W%3BCheng%2C+C%3BVan%2C+K&rft.aulast=Lin&rft.aufirst=W&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thermal Stability of Ricin in Orange Juice T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41016129; 4894286 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Jackson, L AU - Tolleson, W H Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Ricin KW - Thermal stability KW - Fruit juices KW - Citrus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41016129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Thermal+Stability+of+Ricin+in+Orange+Juice&rft.au=Jackson%2C+L%3BTolleson%2C+W+H&rft.aulast=Jackson&rft.aufirst=L&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA Perspective and Guidelines or Regulations for Minimally Processed Foods T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41015960; 4894934 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Skinner, J AU - Larkin, G Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Guidelines KW - FDA KW - Food processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41015960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=FDA+Perspective+and+Guidelines+or+Regulations+for+Minimally+Processed+Foods&rft.au=Skinner%2C+J%3BLarkin%2C+G&rft.aulast=Skinner&rft.aufirst=J&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Current FDA Retail Food Safety Activities and Future Trends T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41015309; 4894843 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Bohm, S Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Food contamination KW - FDA KW - Food KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41015309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Current+FDA+Retail+Food+Safety+Activities+and+Future+Trends&rft.au=Bohm%2C+S&rft.aulast=Bohm&rft.aufirst=S&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Method for Determination of Epichlorohydrin (ECH) in Food Contact Materials by Oxolane Derivatization and Gas Chromatography-Mass Spectrometry (GC-MS) T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41014952; 4894004 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Sung, J AU - Yoon, H AU - Lee, Y Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Spectrometry KW - Epichlorohydrin KW - Mass spectroscopy KW - Gas chromatography KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41014952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=New+Method+for+Determination+of+Epichlorohydrin+%28ECH%29+in+Food+Contact+Materials+by+Oxolane+Derivatization+and+Gas+Chromatography-Mass+Spectrometry+%28GC-MS%29&rft.au=Sung%2C+J%3BYoon%2C+H%3BLee%2C+Y&rft.aulast=Sung&rft.aufirst=J&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Produce Safety: What We Know, What We Need to Know and How to Get there T2 - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AN - 41011948; 4894762 JF - 2008 Annual Meeting and Food Expo of the Institute of Food Technologists AU - Smith, M A Y1 - 2008/06/28/ PY - 2008 DA - 2008 Jun 28 KW - Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41011948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.atitle=Produce+Safety%3A+What+We+Know%2C+What+We+Need+to+Know+and+How+to+Get+there&rft.au=Smith%2C+M+A&rft.aulast=Smith&rft.aufirst=M&rft.date=2008-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Food+Expo+of+the+Institute+of+Food+Technologists&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={7416B4B4 -7931-416A-B8E9-D7C271C3FE8C}&AKey={8616C01D-DC03-41AD-9244-6706B0A8 C9BD} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Determination and confirmation of melamine residues in catfish, trout, tilapia, salmon, and shrimp by liquid chromatography with tandem mass spectrometry. AN - 69225540; 18494486 AB - Pet and food animal (hogs, chicken, and fish) feeds were recently found to be contaminated with melamine (MEL). A quantitative and confirmatory method is presented to determine MEL residues in edible tissues from fish fed this contaminant. Edible tissues were extracted with acidic acetonitrile, defatted with dichloromethane, and cleaned up using mixed-mode cation exchange solid-phase extraction cartridges. Extracts were analyzed by liquid chromatography with tandem mass spectrometry with hydrophilic interaction chromatography and electrospray ionization in positive ion mode. Fish and shrimp tissues were fortified with 10-500 microg/kg (ppb) of MEL with an average recovery of 63.8% (21.5% relative standard deviation, n = 121). Incurred fish tissues were generated by feeding fish up to 400 mg/kg of MEL or a combination of MEL and the related triazine cyanuric acid (CYA). MEL and CYA are known to form an insoluble complex in the kidneys, which may lead to renal failure. Fifty-five treated catfish, trout, tilapia, and salmon were analyzed after withdrawal times of 1-14 days. MEL residues were found in edible tissues from all of the fish with concentrations ranging from 0.011 to 210 mg/kg (ppm). Incurred shrimp and a survey of market seafood products were also analyzed as part of this study. JF - Journal of agricultural and food chemistry AU - Andersen, Wendy C AU - Turnipseed, Sherri B AU - Karbiwnyk, Christine M AU - Clark, Susan B AU - Madson, Mark R AU - Gieseker, Charles M AU - Miller, Ron A AU - Rummel, Nathan G AU - Reimschuessel, Renate AD - Animal Drugs Research Center and Denver District Laboratory, U.S. Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, Colorado 80225-0087, USA. Y1 - 2008/06/25/ PY - 2008 DA - 2008 Jun 25 SP - 4340 EP - 4347 VL - 56 IS - 12 KW - Triazines KW - 0 KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Salmon KW - Shellfish -- analysis KW - Animals KW - Ictaluridae KW - Trout KW - Fishes KW - Animal Feed -- analysis KW - Tilapia KW - Triazines -- analysis KW - Food Contamination -- analysis KW - Chromatography, Liquid KW - Seafood -- analysis KW - Tandem Mass Spectrometry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69225540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Determination+and+confirmation+of+melamine+residues+in+catfish%2C+trout%2C+tilapia%2C+salmon%2C+and+shrimp+by+liquid+chromatography+with+tandem+mass+spectrometry.&rft.au=Andersen%2C+Wendy+C%3BTurnipseed%2C+Sherri+B%3BKarbiwnyk%2C+Christine+M%3BClark%2C+Susan+B%3BMadson%2C+Mark+R%3BGieseker%2C+Charles+M%3BMiller%2C+Ron+A%3BRummel%2C+Nathan+G%3BReimschuessel%2C+Renate&rft.aulast=Andersen&rft.aufirst=Wendy&rft.date=2008-06-25&rft.volume=56&rft.issue=12&rft.spage=4340&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Fjf800295z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf800295z ER - TY - CPAPER T1 - Gas-Phase Chemistry of Fragrance Compounds T2 - 101st Annual Conference and Exhibition of the Air and Waste Management Association AN - 41043251; 4907804 JF - 101st Annual Conference and Exhibition of the Air and Waste Management Association AU - Forester, C AU - Ham, J AU - Wells, J Y1 - 2008/06/24/ PY - 2008 DA - 2008 Jun 24 KW - Fragrance compounds KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41043251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Conference+and+Exhibition+of+the+Air+and+Waste+Management+Association&rft.atitle=Gas-Phase+Chemistry+of+Fragrance+Compounds&rft.au=Forester%2C+C%3BHam%2C+J%3BWells%2C+J&rft.aulast=Forester&rft.aufirst=C&rft.date=2008-06-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Conference+and+Exhibition+of+the+Air+and+Waste+Management+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/browseOptions.asp?MKey={EDF17668- D85D-4ADF-BB4B-795DC0621B8B}&AKey={B2B3355E-B6DC-4154-ABE7-63E874668 9A8} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - BOOK T1 - Child Welfare Policy Manual AN - 61947547; ED501832 AB - This document conveys mandatory policies that have their basis in Federal Law and/or program regulations. It also provides interpretations of Federal Statutes and program regulations initiated by inquiries from State Child Welfare agencies or Administration for Children and Families (ACF) Regional Offices. The manual replaces the Children's Bureau's former policy issuance system, updating and reformatting all of the existing relevant policy issuance's (Policy Announcements and Policy Interpretation Questions) into question and answer format. This manual is broken down into nine main policy areas (with detailed subsections): (1) AFCARS [Adoption and Foster Care Analysis and Reporting System]; (2) CAPTA [Child Abuse Prevention and Treatment Act]; (3) Independent Living; (4) MEPA [Multiethnic Placement Act]/IEAP [Interethnic Adoption Provisions (Small Business Job Protection Act)]; (5) Monitoring; (6) SACWIS [Statewide Automated Child Welfare Information System]; (7) Title IV-B; (8) Title IV-E; and (9) Tribes/Indian Tribal Organizations. Y1 - 2008/06/19/ PY - 2008 DA - 2008 Jun 19 SP - 442 PB - Administration for Children & Families. U.S. Department of Health and Human Services, 380 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Information Systems KW - Guidelines KW - Independent Living KW - Program Costs KW - Welfare Services KW - Adoption KW - Public Policy KW - Racial Differences KW - Foster Care KW - Child Welfare KW - Eligibility KW - Tribes KW - Prevention KW - Federal Legislation KW - Federal Regulation KW - Data Collection KW - Compliance (Legal) KW - Guides KW - Policy Analysis KW - Child Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61947547?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Leveraging exploratory investigational new drug studies to accelerate drug development. AN - 69223754; 18559581 AB - In 2006, the U.S. Food and Drug Administration published its guide on exploratory investigational new drug (IND) studies with the goal of making the approach to early-stage, pilot clinical trials more flexible within the context of current regulations. The exploratory IND allows sponsors to initiate clinical trials of limited scale with reduced preclinical requirements. These studies may be important vehicles for the conduct of proof-of-principle pharmacodynamic investigations of highly potent molecules, for bioavailability studies that require only a single drug dose to be administered, and for imaging trials that permit critical dosimetry and biodistribution investigations of new molecules. These trials were done with no therapeutic intent and must be followed by traditional dose-escalation investigations that are supported by standard preclinical toxicologic and pharmacologic studies. To the extent that they allow early evaluations of essential drug characteristics that can only be obtained in humans, exploratory IND trials have the potential to limit the cost and improve the development times of new agents. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Jacobson-Kram, David AU - Mills, George AD - Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. david.jacobsonkram@fda.hhs.gov Y1 - 2008/06/15/ PY - 2008 DA - 2008 Jun 15 SP - 3670 EP - 3674 VL - 14 IS - 12 SN - 1078-0432, 1078-0432 KW - Drugs, Investigational KW - 0 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Humans KW - Models, Biological KW - Drug Evaluation, Preclinical KW - Diagnostic Imaging -- methods KW - Drugs, Investigational -- therapeutic use KW - Drugs, Investigational -- pharmacokinetics KW - Chemistry, Pharmaceutical -- trends KW - Chemistry, Pharmaceutical -- methods KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69223754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Leveraging+exploratory+investigational+new+drug+studies+to+accelerate+drug+development.&rft.au=Jacobson-Kram%2C+David%3BMills%2C+George&rft.aulast=Jacobson-Kram&rft.aufirst=David&rft.date=2008-06-15&rft.volume=14&rft.issue=12&rft.spage=3670&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-4558 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-4558 ER - TY - JOUR T1 - Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories. AN - 69307632; 18549499 AB - The use of gene expression profiling in both clinical and laboratory settings would be enhanced by better characterization of variance due to individual, environmental, and technical factors. Meta-analysis of microarray data from untreated or vehicle-treated animals within the control arm of toxicogenomics studies could yield useful information on baseline fluctuations in gene expression, although control animal data has not been available on a scale and in a form best served for data-mining. A dataset of control animal microarray expression data was assembled by a working group of the Health and Environmental Sciences Institute's Technical Committee on the Application of Genomics in Mechanism Based Risk Assessment in order to provide a public resource for assessments of variability in baseline gene expression. Data from over 500 Affymetrix microarrays from control rat liver and kidney were collected from 16 different institutions. Thirty-five biological and technical factors were obtained for each animal, describing a wide range of study characteristics, and a subset were evaluated in detail for their contribution to total variability using multivariate statistical and graphical techniques. The study factors that emerged as key sources of variability included gender, organ section, strain, and fasting state. These and other study factors were identified as key descriptors that should be included in the minimal information about a toxicogenomics study needed for interpretation of results by an independent source. Genes that are the most and least variable, gender-selective, or altered by fasting were also identified and functionally categorized. Better characterization of gene expression variability in control animals will aid in the design of toxicogenomics studies and in the interpretation of their results. JF - BMC genomics AU - Boedigheimer, Michael J AU - Wolfinger, Russell D AU - Bass, Michael B AU - Bushel, Pierre R AU - Chou, Jeff W AU - Cooper, Matthew AU - Corton, J Christopher AU - Fostel, Jennifer AU - Hester, Susan AU - Lee, Janice S AU - Liu, Fenglong AU - Liu, Jie AU - Qian, Hui-Rong AU - Quackenbush, John AU - Pettit, Syril AU - Thompson, Karol L AD - CDER, US FDA, Silver Spring, MD 20993, USA . mboedigh@amgen.com Y1 - 2008/06/12/ PY - 2008 DA - 2008 Jun 12 SP - 285 VL - 9 KW - Index Medicus KW - Animals KW - Reference Values KW - Discriminant Analysis KW - Kidney -- metabolism KW - Sex Characteristics KW - Principal Component Analysis KW - Liver -- metabolism KW - Computational Biology KW - Reverse Transcriptase Polymerase Chain Reaction KW - Fasting -- metabolism KW - Multivariate Analysis KW - Rats KW - Rats, Sprague-Dawley KW - Rats, Inbred F344 KW - Databases, Nucleic Acid KW - Rats, Wistar KW - Female KW - Male KW - Genetic Variation KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis -- statistics & numerical data KW - Toxicogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69307632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Sources+of+variation+in+baseline+gene+expression+levels+from+toxicogenomics+study+control+animals+across+multiple+laboratories.&rft.au=Boedigheimer%2C+Michael+J%3BWolfinger%2C+Russell+D%3BBass%2C+Michael+B%3BBushel%2C+Pierre+R%3BChou%2C+Jeff+W%3BCooper%2C+Matthew%3BCorton%2C+J+Christopher%3BFostel%2C+Jennifer%3BHester%2C+Susan%3BLee%2C+Janice+S%3BLiu%2C+Fenglong%3BLiu%2C+Jie%3BQian%2C+Hui-Rong%3BQuackenbush%2C+John%3BPettit%2C+Syril%3BThompson%2C+Karol+L&rft.aulast=Boedigheimer&rft.aufirst=Michael&rft.date=2008-06-12&rft.volume=9&rft.issue=&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2F1471-2164-9-285 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-28 N1 - Date created - 2008-07-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):31-6 [11134512] BMC Bioinformatics. 2007;8:427 [17980031] Pharmacogenetics. 2002 Jan;12(1):55-65 [11773865] Genome Res. 2002 Feb;12(2):292-7 [11827948] Toxicol Pathol. 2002 Jan-Feb;30(1):80-7 [11890480] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1896-901 [12578971] Genome Biol. 2003;4(5):P3 [12734009] Biostatistics. 2003 Apr;4(2):249-64 [12925520] Mol Endocrinol. 2004 Mar;18(3):747-60 [14684848] Endocrinology. 2004 Apr;145(4):1972-9 [14684613] Environ Health Perspect. 2004 Mar;112(4):417-9 [15033589] Environ Health Perspect. 2004 Mar;112(4):428-38 [15033592] Environ Health Perspect. 2004 Mar;112(4):488-94 [15033599] Physiol Genomics. 2004 Apr 13;17(2):230-44 [14762175] Genomics. 2004 Jun;83(6):980-8 [15177552] Nucleic Acids Res. 2005 Jan 1;33(Database issue):D553-5 [15608260] Toxicol Pathol. 2005;33(1):102-10 [15805061] Toxicol Pathol. 2005;33(1):136-45 [15805065] BMC Physiol. 2005;5(1):8 [15953391] Gene. 2005 Aug 15;356:39-48 [15967596] Life Sci. 2006 May 8;78(24):2787-96 [16360708] Toxicol Sci. 2006 Nov;94(1):226-33 [16917072] Mol Endocrinol. 2006 Nov;20(11):2613-29 [16543404] Xenobiotica. 2006 Oct-Nov;36(10-11):938-62 [17118915] J Toxicol Sci. 2006 Dec;31(5):449-69 [17202760] Toxicology. 2001 Mar 7;160(1-3):87-96 [11246128] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2164-9-285 ER - TY - JOUR T1 - Non-traditional vectors for paralytic shellfish poisoning. AN - 69473769; 18728730 AB - Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, are also produced in freshwater cyanobacteria and have been associated with calcareous red macroalgae. STXs are transferred and bioaccumulate throughout aquatic food webs, and can be vectored to terrestrial biota, including humans. Fisheries closures and human intoxications due to STXs have been documented in several non-traditional (i.e. non-filter-feeding) vectors. These include, but are not limited to, marine gastropods, both carnivorous and grazing, crustacea, and fish that acquire STXs through toxin transfer. Often due to spatial, temporal, or a species disconnection from the primary source of STXs (bloom forming dinoflagellates), monitoring and management of such non-traditional PSP vectors has been challenging. A brief literature review is provided for filter feeding (traditional) and non-filter feeding (non-traditional) vectors of STXs with specific reference to human effects. We include several case studies pertaining to management actions to prevent PSP, as well as food poisoning incidents from STX(s) accumulation in non-traditional PSP vectors. JF - Marine drugs AU - Deeds, Jonathan R AU - Landsberg, Jan H AU - Etheridge, Stacey M AU - Pitcher, Grant C AU - Longan, Sara Watt AD - US Food and Drug Administration Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland, 20723, USA. jonathan.deeds@fda.hhs.gov Y1 - 2008/06/10/ PY - 2008 DA - 2008 Jun 10 SP - 308 EP - 348 VL - 6 IS - 2 KW - Saxitoxin KW - 35523-89-8 KW - Index Medicus KW - puffer fish KW - non traditional vectors KW - saxitoxins KW - crustaceans KW - paralytic shellfish poisoning KW - SPFP KW - PSP KW - saxitoxin puffer fish poisoning KW - gastropods KW - STXs KW - public health KW - Seafood -- poisoning KW - Animals KW - Public Health KW - Eutrophication KW - Humans KW - Shellfish Poisoning KW - Saxitoxin -- poisoning KW - Food Chain KW - Paralysis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69473769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+drugs&rft.atitle=Non-traditional+vectors+for+paralytic+shellfish+poisoning.&rft.au=Deeds%2C+Jonathan+R%3BLandsberg%2C+Jan+H%3BEtheridge%2C+Stacey+M%3BPitcher%2C+Grant+C%3BLongan%2C+Sara+Watt&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2008-06-10&rft.volume=6&rft.issue=2&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Marine+drugs&rft.issn=1660-3397&rft_id=info:doi/10.3390%2Fmd20080015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-05 N1 - Date created - 2008-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicon. 1995 May;33(5):667-78 [7660371] Toxicon. 1995 Oct;33(10):1321-9 [8599183] Toxicon. 1995 Jul;33(7):901-8 [8588214] Toxicon. 1996 Apr;34(4):467-74 [8735246] Toxicon. 1995 Dec;33(12):1577-84 [8866615] Toxicon. 1995 Dec;33(12):1669-73 [8866623] Toxicon. 1997 Jan;35(1):137-40 [9028016] Toxicon. 1997 Mar;35(3):423-31 [9080597] Can J Microbiol. 1968 Nov;14(11):1199-204 [5724889] Can J Microbiol. 1969 Feb;15(2):165-73 [5764275] Toxicon. 1972 May;10(3):273-8 [5072092] Aust Vet J. 1975 Dec;51(12):587-8 [816341] Toxicon. 1975 Feb;13(1):1-9 [1053239] Zhonghua Nei Ke Za Zhi. 1981 Apr;20(4):231-2 [7307748] Toxicon. 1982;20(3):662-4 [7101312] Toxicon. 1982;20(4):747-52 [6814018] Biochem Biophys Res Commun. 1983 Jul 29;114(2):465-72 [6882435] Toxicon. 1983;21(4):547-51 [6623494] Toxicon. 1983;21(6):897-900 [6658812] Toxicon. 1984;22(3):381-5 [6474491] Toxicon. 1986;24(2):175-86 [3085292] Trans R Soc Trop Med Hyg. 1986;80(1):64-5 [3727000] Toxicon. 1988;26(1):105-7 [2894726] Toxicon. 1988;26(5):485-90 [3188054] Toxicon. 1988;26(8):707-12 [3188060] Ann N Y Acad Sci. 1960 Nov 17;90:843-55 [13747257] Toxicon. 2005 Feb;45(2):163-9 [15626365] Environ Toxicol Chem. 2005 Jan;24(1):129-35 [15683176] Nature. 2005 Apr 7;434(7034):763-7 [15815630] Environ Toxicol. 2005 Jun;20(3):331-40 [15892061] Toxicon. 2006 Jul;48(1):55-63 [16822534] Chemosphere. 2006 Sep;64(10):1642-9 [16504245] Aquat Toxicol. 2006 Oct 25;80(1):82-91 [16959334] Environ Health Perspect. 2006 Oct;114(10):1502-7 [17035133] Toxicon. 2006 Dec 15;48(8):988-94 [17011007] Toxicon. 1997 Jul;35(7):1081-7 [9248006] Appl Environ Microbiol. 1997 Aug;63(8):3104-10 [9251196] Toxicon. 1997 Aug;35(8):1327-35 [9278980] Toxicon. 1997 Aug;35(8):1341-6 [9278982] Nat Toxins. 1997;5(4):146-51 [9407557] Toxicon. 1998 Feb;36(2):283-98 [9620576] Toxicon. 1998 May;36(5):799-803 [9655641] Toxicon. 1999 Oct;37(10):1359-73 [10414862] J Nat Toxins. 2000 Feb;9(1):63-71 [10701182] Toxicon. 2000 Aug;38(8):1101-9 [10708801] Toxicon. 2000 Dec;38(12):1689-702 [10858510] Toxicon. 2000 Dec;38(12):1871-7 [10858525] Appl Environ Microbiol. 2001 May;67(5):2345-53 [11319121] MMWR Morb Mortal Wkly Rep. 2002 Apr 19;51(15):321-3 [11990235] Toxicon. 2002 Oct;40(10):1463-69 [12368116] Toxicon. 2002 Nov;40(11):1593-9 [12419510] Toxicon. 2004 Feb;43(2):207-12 [15019480] Toxicon. 2004 May;43(6):713-9 [15109892] Mar Pollut Bull. 2004 Jun;48(11-12):1116-21 [15172817] Aquat Toxicol. 2004 Jul 14;68(4):339-50 [15177951] Toxicon. 2004 Dec 1;44(7):765-71 [15500852] Biochemistry. 1966 Apr;5(4):1191-5 [5958196] Science. 1968 Nov 22;162(3856):915-6 [5684499] Toxicon. 2007 Oct;50(5):639-45 [17619042] Toxicon. 2008 Feb;51(2):280-8 [17996918] Toxicon. 1987;25(9):923-8 [3433303] Toxicon. 1989;27(5):579-86 [2749756] Toxicon. 1989;27(5):596-600 [2749759] Toxicon. 1989;27(6):665-74 [2749763] Toxicon. 1990;28(6):707-14 [2402764] J Environ Pathol Toxicol Oncol. 1990 May-Jun;10(3):124-8 [1701485] Toxicon. 1990;28(8):885-93 [2080515] Toxicon. 1994 Feb;32(2):175-83 [8153956] Nat Toxins. 1994;2(4):236-51 [7952949] Nat Toxins. 1994;2(5):254-62 [7866660] Am J Epidemiol. 1995 Apr 15;141(8):766-70 [7709919] Toxicon. 1994 Dec;32(12):1573-9 [7725326] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3390/md20080015 ER - TY - CPAPER T1 - Occupational Monitoring of Carbonaceous Nanomaterials T2 - 40th Central Regional Meeting of the American Chemical Society (CERMACS 2008) AN - 41073750; 4916438 JF - 40th Central Regional Meeting of the American Chemical Society (CERMACS 2008) AU - Ruda- Eberenz, Toni AU - Birch, M Eileen AU - Evans, Douglas E AU - Ku, Bon-Ki Y1 - 2008/06/10/ PY - 2008 DA - 2008 Jun 10 KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41073750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2008%29&rft.atitle=Occupational+Monitoring+of+Carbonaceous+Nanomaterials&rft.au=Ruda-+Eberenz%2C+Toni%3BBirch%2C+M+Eileen%3BEvans%2C+Douglas+E%3BKu%2C+Bon-Ki&rft.aulast=Ruda-+Eberenz&rft.aufirst=Toni&rft.date=2008-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cermacs2008.org/site/ProgramBook-Final3.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Considerations for Whole Parasite Based Malaria Vaccines T2 - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AN - 40964257; 4871273 JF - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AU - Kumar, Sanjai Y1 - 2008/06/08/ PY - 2008 DA - 2008 Jun 08 KW - Parasites KW - Vaccines KW - Malaria KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40964257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.atitle=Considerations+for+Whole+Parasite+Based+Malaria+Vaccines&rft.au=Kumar%2C+Sanjai&rft.aulast=Kumar&rft.aufirst=Sanjai&rft.date=2008-06-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Continuing reassessment of the risks of erythropoiesis-stimulating agents in patients with cancer. AN - 71629380; 18519748 AB - Erythropoiesis-stimulating agents (ESA) are approved for the treatment of anemia in patients with nonmyeloid malignancies whose anemia is due to the effect of concomitantly administered chemotherapy. Since the 1993 approval of epoetin alfa in patients with cancer, the risk of thrombovascular events, decreased survival, and poorer tumor control have been increasingly recognized. The risks of ESAs in patients with cancer and the design of trials to assess these risks have been the topic of discussion at two Oncologic Drugs Advisory Committees in 2004 and 2007. Evaluation of randomized clinical trials comparing use of ESAs to transfusion support alone in patients with active cancer. Six studies (Breast Cancer Erythropoeitin Survival Trial, Evaluation of NeoRecormon on outcome in Head And Neck Cancer in Europe, Danish Head and Neck Cancer, Lymphoid Malignancy, CAN-20, and Anemia of Cancer) investigating ESAs in oncology patients showed decreased survival, decreased duration of locoregional tumor control, and/or increased risk of thrombovascular events. In these six studies, ESA dosing was targeted to achieve and maintain hemoglobin values in excess of current recommendations, and in three of the six studies, ESAs were administered to patients not receiving chemotherapy. ESAs increase the risk of thrombovascular events and result in decreased survival and poorer tumor control when administered to achieve hemoglobin levels of > or =12 g/dL in patients with nonmyeloid malignancies. No completed or ongoing randomized, controlled trial has addressed safety issues of ESAs in patients with chemotherapy-associated anemia using currently approved dosing regimens in an epidermal tumor type. Additional studies are needed to better characterize these risks. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Juneja, Vinni AU - Keegan, Patricia AU - Gootenberg, Joseph E AU - Rothmann, Mark D AU - Shen, Yuan Li AU - Lee, Kyung Y AU - Weiss, Karen D AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak, MD 20993, USA. vinni.juneja@fda.hhs.gov Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 3242 EP - 3247 VL - 14 IS - 11 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Hematinics KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Risk Factors KW - Humans KW - Blood Transfusion KW - Antineoplastic Agents -- adverse effects KW - Neoplasms -- drug therapy KW - Neoplasms -- complications KW - Anemia -- chemically induced KW - Anemia -- drug therapy KW - Hematinics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71629380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Continuing+reassessment+of+the+risks+of+erythropoiesis-stimulating+agents+in+patients+with+cancer.&rft.au=Juneja%2C+Vinni%3BKeegan%2C+Patricia%3BGootenberg%2C+Joseph+E%3BRothmann%2C+Mark+D%3BShen%2C+Yuan+Li%3BLee%2C+Kyung+Y%3BWeiss%2C+Karen+D%3BPazdur%2C+Richard&rft.aulast=Juneja&rft.aufirst=Vinni&rft.date=2008-06-01&rft.volume=14&rft.issue=11&rft.spage=3242&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-1872 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-28 N1 - Date created - 2008-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-1872 ER - TY - JOUR T1 - New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process. AN - 70785500; 18378963 AB - Predicting clinically significant drug interactions during drug development is a challenge for the pharmaceutical industry and regulatory agencies. Since the publication of the US Food and Drug Administration's (FDA's) first in vitro and in vivo drug interaction guidance documents in 1997 and 1999, researchers and clinicians have gained a better understanding of drug interactions. This knowledge has enabled the FDA and the industry to progress and begin to overcome these challenges. The FDA has continued its efforts to evaluate methodologies to study drug interactions and communicate recommendations regarding the conduct of drug interaction studies, particularly for CYP-based and transporter-based drug interactions, to the pharmaceutical industry. A drug interaction Web site was established to document the FDA's current understanding of drug interactions (http://www.fda.gov/cder/drug/drugInteractions/default.htm). This report provides an overview of the evolution of the drug interaction guidances, includes a synopsis of the steps taken by the FDA to revise the original drug interaction guidance documents, and summarizes and highlights updated sections in the current guidance document, Drug Interaction Studies-Study Design, Data Analysis, and Implications for Dosing and Labeling. JF - Journal of clinical pharmacology AU - Huang, Shiew-Mei AU - Strong, John M AU - Zhang, Lei AU - Reynolds, Kellie S AU - Nallani, Srikanth AU - Temple, Robert AU - Abraham, Sophia AU - Habet, Sayed Al AU - Baweja, Raman K AU - Burckart, Gilbert J AU - Chung, Sang AU - Colangelo, Philip AU - Frucht, David AU - Green, Martin D AU - Hepp, Paul AU - Karnaukhova, Elena AU - Ko, Hon-Sum AU - Lee, Jang-Ik AU - Marroum, Patrick J AU - Norden, Janet M AU - Qiu, Wei AU - Rahman, Atiqur AU - Sobel, Solomon AU - Stifano, Toni AU - Thummel, Kenneth AU - Wei, Xiao-Xiong AU - Yasuda, Sally AU - Zheng, Jenny H AU - Zhao, Hong AU - Lesko, Lawrence J AD - Office of Clinical Pharmacology, CDER, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 662 EP - 670 VL - 48 IS - 6 SN - 0091-2700, 0091-2700 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Cytochrome P-450 Enzyme System -- metabolism KW - Cytochrome P-450 Enzyme System -- drug effects KW - Biological Transport -- drug effects KW - Drug Interactions KW - Guidelines as Topic KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70785500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=New+era+in+drug+interaction+evaluation%3A+US+Food+and+Drug+Administration+update+on+CYP+enzymes%2C+transporters%2C+and+the+guidance+process.&rft.au=Huang%2C+Shiew-Mei%3BStrong%2C+John+M%3BZhang%2C+Lei%3BReynolds%2C+Kellie+S%3BNallani%2C+Srikanth%3BTemple%2C+Robert%3BAbraham%2C+Sophia%3BHabet%2C+Sayed+Al%3BBaweja%2C+Raman+K%3BBurckart%2C+Gilbert+J%3BChung%2C+Sang%3BColangelo%2C+Philip%3BFrucht%2C+David%3BGreen%2C+Martin+D%3BHepp%2C+Paul%3BKarnaukhova%2C+Elena%3BKo%2C+Hon-Sum%3BLee%2C+Jang-Ik%3BMarroum%2C+Patrick+J%3BNorden%2C+Janet+M%3BQiu%2C+Wei%3BRahman%2C+Atiqur%3BSobel%2C+Solomon%3BStifano%2C+Toni%3BThummel%2C+Kenneth%3BWei%2C+Xiao-Xiong%3BYasuda%2C+Sally%3BZheng%2C+Jenny+H%3BZhao%2C+Hong%3BLesko%2C+Lawrence+J&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2008-06-01&rft.volume=48&rft.issue=6&rft.spage=662&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270007312153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-18 N1 - Date created - 2008-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Pharmacol. 2009 Mar;49(3):368-9; author reply 370 [19246734] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0091270007312153 ER - TY - JOUR T1 - Detection and quantification of group C rotaviruses in communal sewage. AN - 70774770; 18390677 AB - Group C rotaviruses have been recognized as a cause of acute gastroenteritis in humans, cattle, and swine, although the true epidemiologic and clinical importance of this virus in these hosts has not yet been fully established. A real-time PCR assay based on a broadly reactive primer pair was developed and used to quantitatively determine the viral load of group C rotaviruses in environmental samples. A total of 35 raw and 35 treated sewage samples collected at the same sampling time in four Hungarian sewage treatment plants during a survey in 2005 were tested for the presence of group C rotaviruses. The overall detection rates were 91% (32 of 35) for the influent and 57% (20 of 35) for the effluent samples. Molecular characterization of the amplified partial VP6 gene revealed the cocirculation of human and animal (i.e., bovine and porcine) strains that were easily distinguishable by melting curve analysis. Human strains yielded relatively high viral loads (mean, 1.2 x 10(7); median, 6.9 x 10(5) genome equivalents per liter influent sewage) and appeared to display seasonal activity over the study period, whereas animal strains appeared to circulate throughout the year at much lower average titers (bovine strains mean, 9.9 x 10(4); median, 3.0 x 10(4); porcine strains mean, 3.9 x 10(4); median, 3.1 x 10(4) genome equivalents per liter influent sewage). Our findings suggest that monitoring of communal sewage may provide a good surrogate for investigating the epidemiology and ecology of group C rotaviruses in humans and animals. JF - Applied and environmental microbiology AU - Meleg, Edina AU - Bányai, Krisztián AU - Martella, Vito AU - Jiang, Baoming AU - Kocsis, Béla AU - Kisfali, Péter AU - Melegh, Béla AU - Szucs, György AD - Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, H-7623 Pécs, Hungary. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 3394 EP - 3399 VL - 74 IS - 11 KW - Antigens, Viral KW - 0 KW - Capsid Proteins KW - DNA Primers KW - Sewage KW - VP6 protein, Rotavirus KW - Index Medicus KW - Transition Temperature KW - Animals KW - Base Sequence KW - Reproducibility of Results KW - DNA Primers -- genetics KW - Humans KW - Seasons KW - Molecular Sequence Data KW - Antigens, Viral -- genetics KW - Capsid Proteins -- genetics KW - Rotavirus -- classification KW - Rotavirus -- isolation & purification KW - Sewage -- virology KW - Polymerase Chain Reaction -- methods KW - Rotavirus -- genetics KW - Virology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70774770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Detection+and+quantification+of+group+C+rotaviruses+in+communal+sewage.&rft.au=Meleg%2C+Edina%3BB%C3%A1nyai%2C+Kriszti%C3%A1n%3BMartella%2C+Vito%3BJiang%2C+Baoming%3BKocsis%2C+B%C3%A9la%3BKisfali%2C+P%C3%A9ter%3BMelegh%2C+B%C3%A9la%3BSzucs%2C+Gy%C3%B6rgy&rft.aulast=Meleg&rft.aufirst=Edina&rft.date=2008-06-01&rft.volume=74&rft.issue=11&rft.spage=3394&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.02895-07 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-26 N1 - Date created - 2008-05-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Microbiol. 1998 Jan;36(1):6-10 [9431910] Scand J Infect Dis. 1997;29(4):415-8 [9360259] Virus Res. 2004 Nov;106(1):15-26 [15522443] J Infect Dis. 2005 Sep 1;192 Suppl 1:S146-59 [16088798] Jpn J Infect Dis. 2005 Aug;58(4):255-7 [16116266] J Clin Microbiol. 2005 Sep;43(9):4460-5 [16145092] Emerg Infect Dis. 2006 Feb;12(2):304-6 [16494759] J Clin Virol. 2006 Aug;36(4):306-8 [16774844] J Clin Virol. 2006 Dec;37(4):317-22 [16996791] FEMS Microbiol Rev. 2002 Jun;26(2):187-205 [12069883] J Clin Microbiol. 1999 Dec;37(12):4142-4 [10565947] Jpn J Infect Dis. 1999 Aug;52(4):170-1 [10592901] J Diarrhoeal Dis Res. 1999 Jun;17(2):69-74 [10897889] J Infect Dis. 2000 Sep;182(3):678-84 [10950759] Clin Diagn Lab Immunol. 2001 Jan;8(1):161-5 [11139211] Pediatr Infect Dis J. 2001 Nov;20(11):1088-90 [11734719] Bioinformatics. 2001 Dec;17(12):1244-5 [11751241] J Med Virol. 2002 May;67(1):106-12 [11920824] Crit Rev Microbiol. 2002;28(4):371-409 [12546197] Arch Virol. 2003 Feb;148(2):399-404 [12557002] Appl Environ Microbiol. 2003 Feb;69(2):747-53 [12570991] Appl Environ Microbiol. 2003 Jul;69(7):3919-23 [12839761] J Med Virol. 2004 Jan;72(1):149-55 [14635024] Lancet Infect Dis. 2004 Feb;4(2):91-9 [14871633] J Clin Microbiol. 2004 May;42(5):2127-33 [15131180] J Med Virol. 2004 Sep;74(1):173-9 [15258985] Epidemiol Infect. 2004 Aug;132(4):745-9 [15310177] Eur J Epidemiol. 2004;19(6):589-95 [15330133] J Clin Microbiol. 1982 Oct;16(4):724-6 [6296194] Lancet. 1984 May 26;1(8387):1139-42 [6144874] Scand J Infect Dis. 1988;20(5):475-8 [2851876] J Clin Microbiol. 1990 Mar;28(3):495-503 [1691208] Clin Microbiol Rev. 1993 Jul;6(3):199-210 [8395330] Curr Top Microbiol Immunol. 1994;185:339-71 [8050284] J Infect Dis. 1995 Jul;172(1):45-50 [7797945] N Engl J Med. 1996 Oct 3;335(14):1022-8 [8793926] J Med Virol. 1997 May;52(1):86-91 [9131463] Comp Immunol Microbiol Infect Dis. 1998 Jan;21(1):75-80 [9597309] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.02895-07 ER - TY - JOUR T1 - Strategies and experimental models for evaluating anesthetics: effects on the developing nervous system. AN - 70760594; 18499593 AB - Advances in pediatric and obstetric surgery have resulted in an increase in the duration and complexity of procedures requiring anesthesia. It has been reported that anesthetic drugs cause widespread and dose-dependent apoptosis in the developing rat brain. The similarity of the physiology, pharmacology, metabolism, and reproductive systems of the nonhuman primate to that of the human, especially during pregnancy, make the monkey an exceptionally good animal model for assessing potential neurotoxic effects of anesthetics. The window of vulnerability to these neuronal effects of pediatric anesthetics is restricted to the period of rapid synaptogenesis, also known as the brain growth spurt period. To minimize the risks to children resulting from the use of anesthesia, the following questions should be addressed: 1. What is the relationship between exposure and brain cell loss for drugs commonly used in the practice of pediatric anesthesia (inhaled anesthetics, midazolam, ketamine, and nitrous oxide)? 2. Are there "class effects," or does each drug need to be considered independently? 3. Are there important interactions among the drugs used as anesthetics contributing to the risk of brain cell death? 4. What is the likely period of human vulnerability? Pharmacogenomic/system biology approaches have great potential for helping to advance the understanding of brain-related biological processes, including neuronal plasticity and neurotoxicity. Because of the complexity and temporal features of how developmental neurotoxicity is manifested, pharmacogenomic/systems biology approaches may prove to be useful tools for enhancing our understanding of the biological processes induced by anesthetics. Therefore, the main purpose of this review is to describe the application of these approaches and models, as well as protection strategies, especially as regards the issue of anesthetic-induced neuronal cell death during development. Much of the discussion that follows is based on experiments conducted with ketamine. This is due in part to the use of ketamine in the early studies and the volume of preclinical experimental work performed with this drug, as well as its use in anesthetic studies in developing rodents and nonhuman primates. Although ketamine use in pediatric anesthesia is relatively limited, the findings of the studies are sufficiently strong to merit concern about the N-methyl-d-aspartate antagonist drugs as a class. Our focus on ketamine should not be construed as implying that the risk of neurodegeneration with ketamine is greater, or less, than with other anesthetics. We are simply describing the effects where we have the most preclinical data. JF - Anesthesia and analgesia AU - Wang, Cheng AU - Slikker, William AD - Division of Neurotoxicology, National Center for Toxicological Research/F3900 NCTR Road, Jefferson, AR 72079-9502, USA. cheng.wang@fda.hhs.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1643 EP - 1658 VL - 106 IS - 6 KW - Anesthetics KW - 0 KW - Neuroprotective Agents KW - Ketamine KW - 690G0D6V8H KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Ketamine -- toxicity KW - Synapses -- drug effects KW - Humans KW - Disease Models, Animal KW - Mice KW - Cell Death -- drug effects KW - Pharmacogenetics KW - Risk Assessment KW - Neuroprotective Agents -- pharmacology KW - Rats KW - Animals, Newborn KW - Behavior, Animal -- drug effects KW - Systems Biology KW - Macaca mulatta KW - Synapses -- metabolism KW - Species Specificity KW - Drug Evaluation, Preclinical KW - Anesthetics -- toxicity KW - Nervous System -- drug effects KW - Neurotoxicity Syndromes -- etiology KW - Nerve Degeneration -- chemically induced KW - Nerve Degeneration -- prevention & control KW - Nervous System -- pathology KW - Biomedical Research KW - Nerve Degeneration -- metabolism KW - Neurotoxicity Syndromes -- prevention & control KW - Nerve Degeneration -- pathology KW - Nervous System -- metabolism KW - Nervous System -- growth & development KW - Neurotoxicity Syndromes -- metabolism KW - Neurotoxicity Syndromes -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70760594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Strategies+and+experimental+models+for+evaluating+anesthetics%3A+effects+on+the+developing+nervous+system.&rft.au=Wang%2C+Cheng%3BSlikker%2C+William&rft.aulast=Wang&rft.aufirst=Cheng&rft.date=2008-06-01&rft.volume=106&rft.issue=6&rft.spage=1643&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=1526-7598&rft_id=info:doi/10.1213%2Fane.ob013e3181732c01 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1213/ane.ob013e3181732c01 ER - TY - JOUR T1 - Adjustment for temporal confounders in a reanalysis of a case-control study of beryllium and lung cancer. AN - 70748376; 17890301 AB - To evaluate potential confounding of the association between beryllium and lung cancer in a reanalysis of data from a published case-control study of workers at a beryllium processing facility. The association of cumulative and average beryllium exposure with lung cancer among 142 cases and five age-match controls per case was reanalysed using conditional logistic regression. Adjustment was made independently for potential confounders of hire age and birth year. Alternative adjustments to avoid taking the logarithm of zero were explored. Adjustment for either birth cohort or hire age (two highly correlated factors) attenuated lung cancer risk associated with cumulative exposure; however, lung cancer risk was significantly associated with average exposure using a 10-year lag following adjustment. Stratification of analyses by birth cohort found greater lung cancer risk from cumulative and average exposure for workers born before 1900 than for workers born later. The magnitude of the association between lung cancer and average exposure was not reduced by modifying the method used to take the log of exposure. In this reanalysis, average, but not cumulative, beryllium exposure was related to lung cancer risk after adjustment for birth cohort. Confounding by birth cohort is likely related to differences in smoking patterns for workers born before 1900 and the tendency for workers hired during the World War II era to have been older at hire. JF - Occupational and environmental medicine AU - Schubauer-Berigan, M K AU - Deddens, J A AU - Steenland, K AU - Sanderson, W T AU - Petersen, M R AD - NIOSH, DSHEFS, MS-R15, 4676 Columbia Pkwy, Cincinnati, Ohio 45226, USA. zcg3@cdc.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 379 EP - 383 VL - 65 IS - 6 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Age Factors KW - Aged, 80 and over KW - Humans KW - Confounding Factors (Epidemiology) KW - Case-Control Studies KW - Occupational Exposure -- adverse effects KW - Data Interpretation, Statistical KW - Aged KW - Middle Aged KW - Occupational Exposure -- analysis KW - Male KW - Lung Neoplasms -- chemically induced KW - Occupational Diseases -- chemically induced KW - Beryllium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70748376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Adjustment+for+temporal+confounders+in+a+reanalysis+of+a+case-control+study+of+beryllium+and+lung+cancer.&rft.au=Schubauer-Berigan%2C+M+K%3BDeddens%2C+J+A%3BSteenland%2C+K%3BSanderson%2C+W+T%3BPetersen%2C+M+R&rft.aulast=Schubauer-Berigan&rft.aufirst=M&rft.date=2008-06-01&rft.volume=65&rft.issue=6&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-04 N1 - Date created - 2008-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Occup Environ Med. 2008 Jun;65(6):368-70 [18487425] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Animal studies in the development of medical countermeasures. AN - 70745171; 18323860 AB - The mission of the US Food and Drug Administration (FDA) is to protect public health by ensuring the safety, efficacy, and quality of drugs. In drug development, animal studies play a key role in assessing the safety (toxicology), pharmacokinetics (PK), and proof-of-concept efficacy of a new product. When clinical studies are neither ethical nor feasible to conduct, the Animal Rule (67 FR 37988, 2002) introduces the potential for drug (e.g., countermeasure) approval based on efficacy studies in animals, and appropriate human safety and pharmacokinetic information. The Center for Drug Evaluation and Research is responsible for the review of drug and therapeutic biologic applications. The use of the word "drugs" in this paper will henceforth refer to both drugs and therapeutic biologics (e.g., monoclonal antibodies and small protein molecules). Information about vaccines and other biologics, such as antisera and blood products, should be obtained from the Center for Biologic Evaluation and Research. JF - Clinical pharmacology and therapeutics AU - Roberts, R AU - McCune, S K AD - US Food and Drug Administration, Silver Spring, Maryland, USA. rosemary.roberts@fda.hhs.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 918 EP - 920 VL - 83 IS - 6 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration -- trends KW - Animals KW - Humans KW - United States Food and Drug Administration -- standards KW - Biomedical Research -- standards KW - Biomedical Research -- trends KW - Biomedical Research -- methods KW - Disease Models, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70745171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Animal+studies+in+the+development+of+medical+countermeasures.&rft.au=Roberts%2C+R%3BMcCune%2C+S+K&rft.aulast=Roberts&rft.aufirst=R&rft.date=2008-06-01&rft.volume=83&rft.issue=6&rft.spage=918&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.23 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-12 N1 - Date created - 2008-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2008.23 ER - TY - JOUR T1 - ATSDR evaluation of health effects of benzene and relevance to public health. AN - 69818234; 19022880 AB - As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for Benzene. The primary purpose of this article is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of benzene. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. JF - Toxicology and industrial health AU - Wilbur, S AU - Wohlers, D AU - Paikoff, S AU - Keith, L S AU - Faroon, O AD - Agency for Toxic Substances and Disease Registry (ATSDR), U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA. sdw9@cdc.gov PY - 2008 SP - 263 EP - 398 VL - 24 IS - 5-6 SN - 0748-2337, 0748-2337 KW - Carcinogens, Environmental KW - 0 KW - Benzene KW - J64922108F KW - Index Medicus KW - United States KW - Registries KW - Environmental Monitoring KW - Animals KW - Humans KW - United States Dept. of Health and Human Services KW - Animals, Laboratory KW - Male KW - Female KW - Public Health KW - Benzene -- toxicity KW - Carcinogens, Environmental -- toxicity KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69818234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=ATSDR+evaluation+of+health+effects+of+benzene+and+relevance+to+public+health.&rft.au=Wilbur%2C+S%3BWohlers%2C+D%3BPaikoff%2C+S%3BKeith%2C+L+S%3BFaroon%2C+O&rft.aulast=Wilbur&rft.aufirst=S&rft.date=2008-06-01&rft.volume=24&rft.issue=5-6&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233708090910 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0748233708090910 ER - TY - JOUR T1 - Effect of ethanol on opioid drug permeability through caco-2 cell monolayers. AN - 69531403; 18592381 JF - The AAPS journal AU - Volpe, Donna A AU - Asafu-Adjaye, Ebenezer B AU - Ellison, Christopher D AU - Doddapaneni, Suresh AU - Uppoor, Ramana S AU - Khan, Mansoor A AD - Division of Product Quality Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, Maryland 20993-0002, USA. donna.volpe@fda.hhs.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 360 EP - 362 VL - 10 IS - 2 KW - Analgesics, Opioid KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Caco-2 Cells KW - Ethanol -- adverse effects KW - Ethanol -- pharmacology KW - Cell Membrane Permeability -- drug effects KW - Analgesics, Opioid -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69531403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Effect+of+ethanol+on+opioid+drug+permeability+through+caco-2+cell+monolayers.&rft.au=Volpe%2C+Donna+A%3BAsafu-Adjaye%2C+Ebenezer+B%3BEllison%2C+Christopher+D%3BDoddapaneni%2C+Suresh%3BUppoor%2C+Ramana+S%3BKhan%2C+Mansoor+A&rft.aulast=Volpe&rft.aufirst=Donna&rft.date=2008-06-01&rft.volume=10&rft.issue=2&rft.spage=360&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-008-9046-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-03 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Pharm Sci. 2000 May;10(3):195-204 [10767597] Clin Pharmacokinet. 1978 Nov-Dec;3(6):440-52 [31257] Drugs. 1979 Oct;18(4):299-311 [387374] J Clin Pharmacol. 1981 Apr;21(4):152-6 [6165742] Gut. 1983 May;24(5):399-404 [6840613] Curr Med Res Opin. 2008 Jan;24(1):297-305 [18062845] Scand J Gastroenterol. 1991 Jan;26(1):3-15 [2006395] Clin Investig. 1992 Jun;70(6):487-91 [1392416] Clin Pharmacokinet. 1997 Aug;33(2):79-90 [9260032] Am J Physiol. 1999 Apr;276(4 Pt 1):G965-74 [10198341] J Anal Toxicol. 2006 Apr;30(3):202-9 [16803655] Gastroenterol Clin Biol. 1985;9(12 Pt 2):88-92 [3833611] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1208/s12248-008-9046-3 ER - TY - JOUR T1 - Reducing risk on machinery: a field evaluation pilot study of risk assessment. AN - 69338724; 18643827 AB - A pilot evaluation of the ANSI B11-TR3 Machinery Risk Assessment/Risk Reduction (RA/RR) Guideline was conducted. The TR3 guideline was introduced into five companies on one machinery system in each company with a second machine system serving as a control. A pre-post investigation was performed with safety conditions measured pre and post in both treatment and control and with risk reduction score measured only in the treatment machine system. NIOSH provided a commercially available risk assessment software to facilitate the process. Evaluation measures included avoided injuries, reduced exposure to machinery hazards, pretest and posttest knowledge demonstration, assessment of group processes following training, correct implementation of the guidelines, and degree to which risk reduction recommendations were implemented. The qualitative results of this pilot effort appear to be the best indicators for the way ahead in industrial machine risk assessment. All companies indicated that they derived value in participating in this study and in conducting risk assessments. Quantitative study results suggest that: (1) as measured by the knowledge of the participants before and after the TR3 training, the guidelines can be effective at enhancing employee knowledge of safe machine operations and (2) although the injury reduction trends appear successful, the small sample size in the study size should be considered in interpreting these early results. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Etherton, John AU - Main, Bruce AU - Cloutier, Dennis AU - Christensen, Wayne AD - NIOSH, Center for Safer Solutions, Morgantown, WV, USA. jre@saferjobs.com Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 711 EP - 721 VL - 28 IS - 3 KW - Index Medicus KW - United States KW - Software KW - Occupational Health KW - Humans KW - Equipment Safety KW - United States Occupational Safety and Health Administration KW - Pilot Projects KW - Guidelines as Topic KW - Workplace KW - Time Factors KW - Safety Management KW - National Institute for Occupational Safety and Health (U.S.) KW - Risk Assessment KW - Accidents, Occupational -- prevention & control KW - Risk Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69338724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Reducing+risk+on+machinery%3A+a+field+evaluation+pilot+study+of+risk+assessment.&rft.au=Etherton%2C+John%3BMain%2C+Bruce%3BCloutier%2C+Dennis%3BChristensen%2C+Wayne&rft.aulast=Etherton&rft.aufirst=John&rft.date=2008-06-01&rft.volume=28&rft.issue=3&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=1539-6924&rft_id=info:doi/10.1111%2Fj.1539-6924.2008.01045.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1539-6924.2008.01045.x ER - TY - JOUR T1 - Role of the U.S. Food and Drug Administration in the regulatory management of human listeriosis in the United States. AN - 69281939; 18592761 AB - From 1986 to 2006, the incidence of listeriosis in the United States dropped from approximately seven to three cases per million population, a reduction that most likely reflects the joint efforts of industry, government, consumers, and academia. Herein, we describe the U.S. Food and Drug Administration (FDA) strategy over the past three decades to combat listeriosis. Specifically, we discuss early actions taken to address outbreaks during the 1980s, policy decisions regarding the presence of Listeria monocytogenes in FDA-regulated foods, FDA compliance programs with L. monocytogenes components, enforcement actions to remove L. monocytogenes-contaminated products from the market (i.e., recalls) or to prevent entry of such products into the market (i.e., import detentions and refusals), research milestones, outreach and education efforts, and selected special projects. Evolving demographic trends in the United States may pose a challenge to further reduction of the incidence of listeriosis. JF - Journal of food protection AU - Klontz, Karl C AU - McCarthy, Patrick V AU - Datta, Atin R AU - Lee, Judy O AU - Acheson, David W K AU - Brackett, Robert E AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA. karl.klontz@fda.hhs.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1277 EP - 1286 VL - 71 IS - 6 SN - 0362-028X, 0362-028X KW - Index Medicus KW - Public Health KW - Food Microbiology KW - Consumer Product Safety KW - Disease Outbreaks -- prevention & control KW - Humans KW - United States -- epidemiology KW - Risk Assessment KW - Prevalence KW - Listeriosis -- epidemiology KW - Food Contamination -- prevention & control KW - United States Food and Drug Administration KW - Listeria monocytogenes -- growth & development KW - Listeriosis -- prevention & control KW - Legislation, Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69281939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Role+of+the+U.S.+Food+and+Drug+Administration+in+the+regulatory+management+of+human+listeriosis+in+the+United+States.&rft.au=Klontz%2C+Karl+C%3BMcCarthy%2C+Patrick+V%3BDatta%2C+Atin+R%3BLee%2C+Judy+O%3BAcheson%2C+David+W+K%3BBrackett%2C+Robert+E&rft.aulast=Klontz&rft.aufirst=Karl&rft.date=2008-06-01&rft.volume=71&rft.issue=6&rft.spage=1277&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-11 N1 - Date created - 2008-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - FDA drug approval summary: nelarabine (Arranon) for the treatment of T-cell lymphoblastic leukemia/lymphoma. AN - 69270580; 18586926 AB - To describe the clinical trials leading to U.S. Food and Drug Administration (FDA) approval of nelarabine (Arranon), a new purine analogue, for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens. Two phase II trials, one conducted in pediatric patients and the other in adult patients, were reviewed. Patients were in their first or subsequent relapse and/or were refractory to first-line therapy. The dose and schedule of i.v. nelarabine in the pediatric and adult studies were 650 mg/m2 per day daily for 5 days and 1,500 mg/m2 i.v. on days 1, 3, and 5, respectively. Treatments were repeated every 21 days. Study endpoints were the rates of complete response (CR) and CR with incomplete hematologic or bone marrow recovery (CR*). The pediatric efficacy population consisted of 39 patients who had relapsed after, or had been refractory to, two or more induction regimens. CR to nelarabine treatment was observed in five patients (13%) and CR+CR* was observed in nine patients (23%). The adult efficacy population consisted of 28 patients. CR to nelarabine treatment was observed in five patients (18%) and CR+CR* was observed in six patients (21%). Neurologic toxicity was dose limiting for both pediatric and adult patients. Other severe toxicities included hematologic, hepatic, and metabolic laboratory abnormalities in pediatric patients and gastrointestinal and pulmonary toxicities in adults. On October 28, 2005, the FDA granted accelerated approval for nelarabine for treatment of patients with relapsed or refractory T-ALL/T-LBL after at least two prior regimens. This use is based on the induction of CR. The applicant will conduct postmarketing clinical trials to demonstrate clinical benefit, for example, survival prolongation. JF - The oncologist AU - Cohen, Martin H AU - Johnson, John R AU - Justice, Robert AU - Pazdur, Richard AD - Division of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA. martin.cohen@fda.hhs.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 709 EP - 714 VL - 13 IS - 6 SN - 1083-7159, 1083-7159 KW - Arabinonucleosides KW - 0 KW - nelarabine KW - 60158CV180 KW - Index Medicus KW - United States KW - Infant KW - United States Food and Drug Administration KW - Clinical Trials, Phase II as Topic KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Child, Preschool KW - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy KW - Drug Approval -- legislation & jurisprudence KW - Leukemia-Lymphoma, Adult T-Cell -- drug therapy KW - Arabinonucleosides -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69270580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+drug+approval+summary%3A+nelarabine+%28Arranon%29+for+the+treatment+of+T-cell+lymphoblastic+leukemia%2Flymphoma.&rft.au=Cohen%2C+Martin+H%3BJohnson%2C+John+R%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Cohen&rft.aufirst=Martin&rft.date=2008-06-01&rft.volume=13&rft.issue=6&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/10.1634%2Ftheoncologist.2006-0017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-29 N1 - Date created - 2008-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2006-0017 ER - TY - JOUR T1 - Low-fidelity DNA synthesis by human DNA polymerase theta. AN - 69243707; 18503084 AB - Human DNA polymerase theta (pol or POLQ) is a proofreading-deficient family A enzyme implicated in translesion synthesis (TLS) and perhaps in somatic hypermutation (SHM) of immunoglobulin genes. These proposed functions and kinetic studies imply that pol may synthesize DNA with low fidelity. Here, we show that when copying undamaged DNA, pol generates single base errors at rates 10- to more than 100-fold higher than for other family A members. Pol adds single nucleotides to homopolymeric runs at particularly high rates, exceeding 1% in certain sequence contexts, and generates single base substitutions at an average rate of 2.4 x 10(-3), comparable to inaccurate family Y human pol kappa (5.8 x 10(-3)) also implicated in TLS. Like pol kappa, pol is processive, implying that it may be tightly regulated to avoid deleterious mutagenesis. Pol also generates certain base substitutions at high rates within sequence contexts similar to those inferred to be copied by pol during SHM of immunoglobulin genes in mice. Thus, pol is an exception among family A polymerases, and its low fidelity is consistent with its proposed roles in TLS and SHM. JF - Nucleic acids research AU - Arana, Mercedes E AU - Seki, Mineaki AU - Wood, Richard D AU - Rogozin, Igor B AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 3847 EP - 3856 VL - 36 IS - 11 KW - Nucleotides KW - 0 KW - DNA KW - 9007-49-2 KW - DNA polymerase theta KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Nucleotides -- metabolism KW - Somatic Hypermutation, Immunoglobulin KW - Humans KW - Mutation KW - Nucleotides -- analysis KW - DNA -- chemistry KW - DNA -- biosynthesis KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69243707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Low-fidelity+DNA+synthesis+by+human+DNA+polymerase+theta.&rft.au=Arana%2C+Mercedes+E%3BSeki%2C+Mineaki%3BWood%2C+Richard+D%3BRogozin%2C+Igor+B%3BKunkel%2C+Thomas+A&rft.aulast=Arana&rft.aufirst=Mercedes&rft.date=2008-06-01&rft.volume=36&rft.issue=11&rft.spage=3847&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkn310 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-21 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2006;34(17):4731-42 [16971464] Biochim Biophys Acta. 1992 Nov 15;1171(1):11-8 [1420357] DNA Repair (Amst). 2007 Feb 4;6(2):213-23 [17118716] J Biol Chem. 2007 Jun 15;282(24):17387-94 [17449470] J Biol Chem. 1997 Jan 24;272(4):2559-69 [8999973] J Biol Chem. 1997 Aug 8;272(32):20205-12 [9242698] J Mol Biol. 1999 Jun 18;289(4):835-50 [10369765] Genomics. 1999 Jul 1;59(1):90-6 [10395804] EMBO J. 2004 Nov 10;23(22):4484-94 [15496986] Mol Cell Biol. 2004 Dec;24(23):10381-9 [15542845] Adv Protein Chem. 2004;69:137-65 [15588842] J Exp Med. 2005 Apr 18;201(8):1191-6 [15824086] J Immunol. 2005 Jun 15;174(12):7781-6 [15944281] Annu Rev Biochem. 2005;74:317-53 [15952890] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8656-61 [15939880] J Biol Chem. 2005 Jun 24;280(25):23446-50 [15879599] J Biol Chem. 2005 Aug 19;280(33):29980-7 [15964835] Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13986-91 [16172387] J Biol Chem. 1993 May 15;268(14):10312-23 [7683674] J Biol Chem. 1993 May 15;268(14):10324-34 [7683675] J Biol Chem. 1993 Jun 25;268(18):13462-71 [8390464] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6830-4 [8041704] Methods Enzymol. 1995;262:217-32 [8594349] EMBO J. 2005 Nov 2;24(21):3757-69 [16222339] Cell. 2006 Jan 27;124(2):331-42 [16439207] Trends Biochem Sci. 2006 Apr;31(4):206-14 [16545956] J Biol Chem. 2006 May 19;281(20):13869-72 [16571727] Front Biosci. 2006;11:2496-517 [16720328] Nat Cell Biol. 2006 Jun;8(6):640-2 [16738703] Cell Cycle. 2006 May;5(10):1044-7 [16687932] J Biol Chem. 2006 Aug 18;281(33):23445-55 [16787914] Mol Cell. 2006 Oct 6;24(1):115-25 [17018297] Plant Mol Biol. 2007 Jul;64(5):601-11 [17522954] DNA Repair (Amst). 2008 Jan 1;7(1):119-27 [17920341] Mol Cell. 2007 Dec 14;28(5):702-7 [18082594] Eur J Immunol. 2008 Jan;38(1):227-39 [18081040] Mol Cell. 2007 Dec 28;28(6):1058-70 [18158902] Cell Res. 2008 Jan;18(1):148-61 [18166979] J Biol Chem. 1996 Oct 4;271(40):24954-61 [8798775] J Biol Chem. 1999 Nov 19;274(47):33313-9 [10559208] J Biol Chem. 2000 Dec 15;275(50):39678-84 [11006276] Nat Immunol. 2001 Jun;2(6):530-6 [11376340] Nat Immunol. 2001 Jun;2(6):537-41 [11376341] J Mol Biol. 2001 Sep 14;312(2):335-46 [11554790] Cell. 2001 Oct 5;107(1):91-102 [11595188] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] Annu Rev Biochem. 2002;71:191-219 [12045095] J Mol Biol. 2002 May 31;319(2):359-69 [12051913] Genetics. 2003 Mar;163(3):1031-40 [12663541] J Biol Chem. 2003 Aug 22;278(34):32014-9 [12794064] J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698] Nucleic Acids Res. 2003 Nov 1;31(21):6117-26 [14576298] J Biol Chem. 2003 Oct 31;278(44):43770-80 [12882968] Int J Cancer. 2004 Mar10;109(1):9-16 [14735462] J Exp Med. 2004 Jan 19;199(2):265-70 [14734526] J Exp Med. 2004 Apr 5;199(7):917-24 [15051760] Cold Spring Harb Symp Quant Biol. 1966;31:77-84 [5237214] Biochim Biophys Acta. 1988 Nov 10;951(1):1-15 [2847793] Nucleic Acids Res. 1990 Jul 11;18(13):3739-44 [2374708] J Biol Chem. 1990 Aug 15;265(23):13878-87 [2199444] DNA Repair (Amst). 2006 Nov 8;5(11):1384-91 [16890500] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkn310 ER - TY - JOUR T1 - Targeting IL-13Ralpha2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin. AN - 69231212; 18566228 AB - We have shown previously that high-affinity receptors for interleukin-13 (IL-13Ralpha2) are overexpressed on a variety of solid cancer cells, diseased fibroblasts, and other cells, and a chimeric fusion protein composed of human IL-13 and mutated Pseudomonas exotoxin (IL-13-PE38) is highly and specifically cytotoxic to these cells in vitro and in vivo. To improve the specificity for the target, we isolated specific antibodies against IL-13Ralpha2 from human single-chain Fv (scFv) antibody phage library and developed immunotoxin by selecting two high-affinity clones of scFv and fused to PE. The fusion chimeric gene was expressed in Escherichia coli, and highly purified IL-13R-specific immunotoxin, termed anti-IL-13Ralpha2(scFv)-PE38, was tested for its cytotoxicity. This molecule was highly cytotoxic to U251 glioma and PM-RCC renal cell carcinoma cell lines in vitro. The cytotoxic activity was neutralized by purified extracellular domain of IL-13Ralpha2 but not by IL-13, indicating that cytotoxic activity is specific. Anti-IL-13Ralpha2(scFv)-PE38 showed significant antitumor activity in immunodeficient mice with s.c. glioma tumors. Both i.p. and i.t. routes of administration showed antitumor activity in a dose-dependent manner. The maximum tolerated dose of anti-IL-13Ralpha2(scFv)-PE38 was 200 microg/kg i.p. twice daily for 5 days. These results indicate that anti-IL-13Ralpha2(scFv)-PE38 is a highly selective therapeutic agent for cancer therapy and should be further tested in animal models of human cancer. JF - Molecular cancer therapeutics AU - Kioi, Mitomu AU - Seetharam, Saraswathy AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, NIH Building 29B, Room 2NN20, 29 Lincoln Drive, Bethesda, MD 20892, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1579 EP - 1587 VL - 7 IS - 6 SN - 1535-7163, 1535-7163 KW - Antibodies KW - 0 KW - Antineoplastic Agents KW - Exotoxins KW - Immunoglobulin Variable Region KW - Immunotoxins KW - Interleukin-13 Receptor alpha2 Subunit KW - Recombinant Fusion Proteins KW - Index Medicus KW - Clone Cells KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Humans KW - Recombinant Fusion Proteins -- isolation & purification KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Cell Death -- drug effects KW - Recombinant Fusion Proteins -- metabolism KW - Glioblastoma -- metabolism KW - Xenograft Model Antitumor Assays KW - Protein Structure, Tertiary KW - Antineoplastic Agents -- pharmacology KW - Interleukin-13 Receptor alpha2 Subunit -- metabolism KW - Exotoxins -- pharmacology KW - Antibodies -- pharmacology KW - Mutation -- genetics KW - Immunotoxins -- isolation & purification KW - Interleukin-13 Receptor alpha2 Subunit -- chemistry KW - Immunotoxins -- pharmacology KW - Pseudomonas -- metabolism KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69231212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Targeting+IL-13Ralpha2-positive+cancer+with+a+novel+recombinant+immunotoxin+composed+of+a+single-chain+antibody+and+mutated+Pseudomonas+exotoxin.&rft.au=Kioi%2C+Mitomu%3BSeetharam%2C+Saraswathy%3BPuri%2C+Raj+K&rft.aulast=Kioi&rft.aufirst=Mitomu&rft.date=2008-06-01&rft.volume=7&rft.issue=6&rft.spage=1579&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/10.1158%2F1535-7163.MCT-07-2131 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-22 N1 - Date created - 2008-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1535-7163.MCT-07-2131 ER - TY - JOUR T1 - Heme-oxygenase 1 gene expression is a marker for hexavalent chromium-induced stress and toxicity in human dermal fibroblasts. AN - 69192962; 18332044 AB - Several adverse health effects, including irritant and allergic contact dermatitis, have been reported among workers who are occupationally exposed to chromium-containing compounds. Human dermal fibroblasts were used as an in vitro experimental model to study the potential mechanisms underlying hexavalent chromium [Cr(VI)]-induced dermal toxicity. Exposure of the fibroblasts to 5 microM Cr(VI) (LC50 for a 24-h exposure period) followed by microarray analysis of the gene expression profile revealed overexpression of several genes including those involved in cell stress response. The cellular level of glutathione, the major antioxidant molecule present in the cells, was significantly lower in the Cr(VI)-treated cells compared to the corresponding control cells. The Cr(VI)-induced overexpression of heme-oxygenase 1 messenger RNA (HO-1) in the fibroblasts was significantly blocked by actinomycin D and by inhibitors of MAP kinase pathways. The Cr(VI)-induced cytotoxicity and the overexpression of the HO-1 gene were dependent on the glutathione level of the fibroblasts. Buthionine sulfoximine-mediated GSH depletion resulted in enhanced Cr(VI) cytotoxicity and further overexpression of the HO-1 gene. On the other hand, elevated cellular levels of glutathione resulting from pretreating the cells with GSH significantly protected the cells against the Cr(VI)-induced cytotoxicity and blocked the HO-1 gene's overexpression. Pretreating the fibroblasts with N-acetyl cysteine also significantly reduced the Cr(VI)-induced cytotoxicity and overexpression of the HO-1 gene. In conclusion, depletion of GSH leading to cellular stress is a major mechanism responsible for Cr(VI)-induced cytotoxicity. Furthermore, the expression level of HO-1 gene is a marker for Cr(VI)-induced cell stress leading to cytotoxicity. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Joseph, Pius AU - He, Quanren AU - Umbright, Christina AD - Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia 26505, USA. pjoseph1@cdc.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 325 EP - 334 VL - 103 IS - 2 KW - Antimetabolites KW - 0 KW - Biomarkers KW - Carcinogens, Environmental KW - Enzyme Inhibitors KW - Nucleic Acid Synthesis Inhibitors KW - Chromium KW - 0R0008Q3JB KW - chromium hexavalent ion KW - 18540-29-9 KW - Dactinomycin KW - 1CC1JFE158 KW - Buthionine Sulfoximine KW - 5072-26-4 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Glutathione KW - GAN16C9B8O KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Fibroblasts -- drug effects KW - Glutathione -- metabolism KW - Humans KW - Acetylcysteine -- pharmacology KW - Glutathione -- deficiency KW - Fibroblasts -- metabolism KW - Nucleic Acid Synthesis Inhibitors -- pharmacology KW - Antimetabolites -- pharmacology KW - Dactinomycin -- pharmacology KW - Fibroblasts -- pathology KW - Oxidative Stress -- drug effects KW - Microarray Analysis KW - Enzyme Inhibitors -- pharmacology KW - Buthionine Sulfoximine -- pharmacology KW - Heme Oxygenase-1 -- antagonists & inhibitors KW - Skin -- drug effects KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Skin -- metabolism KW - Skin -- pathology KW - Heme Oxygenase-1 -- metabolism KW - Biomarkers -- metabolism KW - Heme Oxygenase-1 -- genetics KW - Carcinogens, Environmental -- toxicity KW - Chromium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69192962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Heme-oxygenase+1+gene+expression+is+a+marker+for+hexavalent+chromium-induced+stress+and+toxicity+in+human+dermal+fibroblasts.&rft.au=Joseph%2C+Pius%3BHe%2C+Quanren%3BUmbright%2C+Christina&rft.aulast=Joseph&rft.aufirst=Pius&rft.date=2008-06-01&rft.volume=103&rft.issue=2&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfn048 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-12 N1 - Date created - 2008-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfn048 ER - TY - JOUR T1 - Engineering case reports. Effectiveness of local exhaust ventilation (LEV) in controlling engineered nanomaterial emissions during reactor cleanout operations. AN - 69129486; 18432476 JF - Journal of occupational and environmental hygiene AU - Methner, Mark M AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - D63 EP - D69 VL - 5 IS - 6 KW - Air Pollutants, Occupational KW - 0 KW - Manganese Compounds KW - Oxides KW - Silver Compounds KW - Cobalt KW - 3G0H8C9362 KW - manganese oxide KW - 64J2OA7MH3 KW - disilver oxide KW - 897WUN6G6T KW - cobalt oxide KW - USK772NS56 KW - Index Medicus KW - Environmental Monitoring KW - Occupational Health KW - Microscopy, Electron, Transmission KW - Occupational Exposure -- prevention & control KW - Engineering KW - Humans KW - Occupational Exposure -- analysis KW - Nanostructures -- ultrastructure KW - Ventilation -- methods KW - Oxides -- analysis KW - Air Pollutants, Occupational -- analysis KW - Silver Compounds -- analysis KW - Cobalt -- analysis KW - Nanostructures -- analysis KW - Manganese Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69129486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Engineering+case+reports.+Effectiveness+of+local+exhaust+ventilation+%28LEV%29+in+controlling+engineered+nanomaterial+emissions+during+reactor+cleanout+operations.&rft.au=Methner%2C+Mark+M&rft.aulast=Methner&rft.aufirst=Mark&rft.date=2008-06-01&rft.volume=5&rft.issue=6&rft.spage=D63&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620802059393 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-09 N1 - Date created - 2008-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620802059393 ER - TY - JOUR T1 - Assessment of ecological regression in the study of colon, breast, ovary, non-Hodgkin's lymphoma, or prostate cancer and residential UV. AN - 69102272; 18414201 AB - Recent ecological studies have suggested a possible association between exposure to ultraviolet-B (UVB) radiation and reduction in the risk of various cancers; however, ecological studies are known to be subject to bias. The objective of this study was to demonstrate difficulties with the ecological approach. We conducted a multicountry ecological study using cancer incidence rates, residential UV levels, dietary intake, and different sociodemographic variables for 38 locations spanning 33 countries worldwide. The effect of residential UV exposure on cancer incidence was assessed using multiple linear regression models. The results of our multivariate analyses show no indication of an inverse association between residential UV levels and the risk of colon, non-Hodgkin's lymphoma (NHL), ovarian, prostate, or breast cancer in women. For colon cancer and NHL, a significant positive association was calculated. The rates of melanoma, which were used to examine the methods of this study, showed a strong and significant (P<0.01) association with solar radiation. Our results provide no evidence to support previous ecological results that UV exposure may reduce the risk of NHL, colon, breast, ovary, or prostate cancer. The study demonstrates the high sensitivity of ecological studies to adjustments for various confounders, and casts doubts on results of ecological analyses in this field. JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) AU - Waltz, Paul AU - Chodick, Gabriel AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 279 EP - 286 VL - 17 IS - 3 KW - Index Medicus KW - Ecosystem KW - Regression Analysis KW - Humans KW - Cohort Studies KW - Residence Characteristics KW - Geography KW - Male KW - Female KW - Multivariate Analysis KW - Prostatic Neoplasms -- etiology KW - Ovarian Neoplasms -- etiology KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Colonic Neoplasms -- epidemiology KW - Prostatic Neoplasms -- epidemiology KW - Colonic Neoplasms -- etiology KW - Ultraviolet Rays -- adverse effects KW - Lymphoma, Non-Hodgkin -- etiology KW - Environmental Exposure KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- epidemiology KW - Ovarian Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69102272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.atitle=Assessment+of+ecological+regression+in+the+study+of+colon%2C+breast%2C+ovary%2C+non-Hodgkin%27s+lymphoma%2C+or+prostate+cancer+and+residential+UV.&rft.au=Waltz%2C+Paul%3BChodick%2C+Gabriel&rft.aulast=Waltz&rft.aufirst=Paul&rft.date=2008-06-01&rft.volume=17&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.issn=1473-5709&rft_id=info:doi/10.1097%2FCEJ.0b013e3282b6fd0f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-30 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Eur J Cancer Prev. 2008 Aug;17(4):384 [18562966] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CEJ.0b013e3282b6fd0f ER - TY - JOUR T1 - Funneling Child Welfare Consumers into and through the Mental Health System: Assessment, Referral, and Quality Issues AN - 61426655; 200806249 AB - This qualitative study explores how consumers of child welfare services reach nonpsychiatric mental health providers and the perceived quality of these services. It relies on iterative interviews with individuals and groups, as well as on court observations from one metropolitan area. Results suggest that, consistent with theories of street-level bureaucracy, efficiency issues drive mental health service use, as clients are routinely subjected to psychological evaluations and funneled into mental health services as a matter of course. Referral practices are shaped by child welfare professionals' routines, discretion, and desire to meet such system objectives as providing short turnaround times for reports. The results suggest that, despite stakeholders' best intentions, maltreated children are not benefiting from thoughtful processes geared to screen for, assess, and provide targeted treatment for unmet mental health needs. Adapted from the source document. JF - Social Service Review AU - Fedoravicius, Nicole AU - McMillen, J Curtis AU - Rowe, Jill E AU - Kagotho, Njeri AU - Ware, Norma C AD - Center for Mental Health Services Research, Washington University, St. Louis Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 273 EP - 290 PB - University of Chicago Press, IL VL - 82 IS - 2 SN - 0037-7961, 0037-7961 KW - Bureaucracy KW - Efficiency KW - Motivation KW - Mental Health Services KW - Psychological Theories KW - Metropolitan Areas KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61426655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Service+Review&rft.atitle=Funneling+Child+Welfare+Consumers+into+and+through+the+Mental+Health+System%3A+Assessment%2C+Referral%2C+and+Quality+Issues&rft.au=Fedoravicius%2C+Nicole%3BMcMillen%2C+J+Curtis%3BRowe%2C+Jill+E%3BKagotho%2C+Njeri%3BWare%2C+Norma+C&rft.aulast=Fedoravicius&rft.aufirst=Nicole&rft.date=2008-06-01&rft.volume=82&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Social+Service+Review&rft.issn=00377961&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2008-11-06 N1 - Number of references - 23 N1 - Last updated - 2016-09-28 N1 - CODEN - SSRVAW N1 - SubjectsTermNotLitGenreText - Mental Health Services; Psychological Theories; Metropolitan Areas; Efficiency; Bureaucracy; Motivation ER - TY - BOOK T1 - Estimating the Permeation Resistance of Nonporous Barrier Polymers to Sulfur Mustard (HD) and Sarin (GB) Chemical Warfare Agents Using Liquid Simulants AN - 58792288; 2008-218166 AB - The purpose of this document is to report the results of the NIOSH Chemical Warfare Agent (CWA) Simulant Project that had the following goals: 1.) Identify chemicals (simulants) that simulate the permeation of Sarin (GB) and sulfur mustard (HD) through elastomeric barrier materials that are commonly used in respirators. 2.) Develop a convenient and reliable laboratory procedure (test method) that can be used by Personal Protective Equipment (PPE) manufacturers for estimating GB and HD permeation rates through barrier materials using the simulants. PPE manufacturers can use this method to screen and deselect candidate barrier materials during product development testing. Advancements in this research can benefit the first responder community by providing PPE manufacturers with information and testing techniques that will reduce the time and resources needed to engineer products that weigh less, have better permeation resistance, are less cumbersome, and could potentially be less expensive. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Jun 2008, 97 pp. AU - Bartram, Philip W AU - Lindsay, Robert S AU - Palya, Frank Jr AU - Rivin, Donald AU - Rodriguez, Axel AU - Shuely, Wendel J Y1 - 2008/06// PY - 2008 DA - June 2008 EP - 97p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Social conditions and policy - Public safety and security KW - International relations - War KW - Military and defense policy - Military planning, strategy, and operations KW - Science and technology policy - Science and science policy and research KW - Laboratories KW - Chemical warfare KW - Safety measures KW - Working conditions KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58792288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bartram%2C+Philip+W%3BLindsay%2C+Robert+S%3BPalya%2C+Frank+Jr%3BRivin%2C+Donald%3BRodriguez%2C+Axel%3BShuely%2C+Wendel+J&rft.aulast=Bartram&rft.aufirst=Philip&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=97p&rft.isbn=&rft.btitle=Estimating+the+Permeation+Resistance+of+Nonporous+Barrier+Polymers+to+Sulfur+Mustard+%28HD%29+and+Sarin+%28GB%29+Chemical+Warfare+Agents+Using+Liquid+Simulants&rft.title=Estimating+the+Permeation+Resistance+of+Nonporous+Barrier+Polymers+to+Sulfur+Mustard+%28HD%29+and+Sarin+%28GB%29+Chemical+Warfare+Agents+Using+Liquid+Simulants&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2008-141/pdfs/2008-141.pdf LA - English DB - PAIS Index N1 - Date revised - 2009-01-09 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - SuppNotes - NIOSH Publication No. 2008-141 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Three-dimensional time-lapse velocity tomography of an underground longwall panel AN - 50649235; 2008-103492 AB - Three-dimensional velocity tomograms were generated to image the stress redistribution around an underground coal longwall panel to produce a better understanding of the mechanisms that lead to ground failure, especially rockbursts. Mining-induced microseismic events provided passive sources for the three-dimensional velocity tomography. Surface-mounted geophones monitored microseismic activity for 18 days. Eighteen tomograms were generated and high-velocity regions correlated with high abutment stresses predicted by numerical modeling. Additionally, the high-velocity regions were observed to redistribute as the longwall face retreated, indicating that velocity tomography may be an appropriate technology for monitoring stress redistribution in underground mines. JF - International Journal of Rock Mechanics and Mining Sciences (1997) AU - Luxbacher, Kray AU - Westman, Erik AU - Swanson, Peter AU - Karfakis, Mario Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 478 EP - 485 PB - Elsevier, Oxford-New York VL - 45 IS - 4 SN - 1365-1609, 1365-1609 KW - tomography KW - mining KW - failures KW - geologic hazards KW - underground mining KW - three-dimensional models KW - site exploration KW - roof control KW - stress KW - mathematical models KW - rock mechanics KW - sedimentary rocks KW - longwall mining KW - rock bursts KW - coal KW - tunnels KW - time-lapse methods KW - velocity KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50649235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.atitle=Three-dimensional+time-lapse+velocity+tomography+of+an+underground+longwall+panel&rft.au=Luxbacher%2C+Kray%3BWestman%2C+Erik%3BSwanson%2C+Peter%3BKarfakis%2C+Mario&rft.aulast=Luxbacher&rft.aufirst=Kray&rft.date=2008-06-01&rft.volume=45&rft.issue=4&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.issn=13651609&rft_id=info:doi/10.1016%2Fj.ijrmms.2007.07.015 L2 - http://www.sciencedirect.com/science/journal/13651609 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2008-01-01 N1 - Number of references - 45 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - IJRMA2 N1 - SubjectsTermNotLitGenreText - coal; failures; geologic hazards; longwall mining; mathematical models; mining; rock bursts; rock mechanics; roof control; sedimentary rocks; site exploration; stress; three-dimensional models; time-lapse methods; tomography; tunnels; underground mining; velocity DO - http://dx.doi.org/10.1016/j.ijrmms.2007.07.015 ER - TY - CPAPER T1 - Heterogeneity of Tn1546 among VanA-type VRE Isolates of Enterococcus faecium T2 - 108th General Meeting of the American Society for Microbiology AN - 41008685; 4883740 JF - 108th General Meeting of the American Society for Microbiology AU - Sung, K AU - Khan, S A AU - Nawaz, M S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Antimicrobial agents KW - Antimicrobial resistance KW - Enterococcus faecium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41008685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Heterogeneity+of+Tn1546+among+VanA-type+VRE+Isolates+of+Enterococcus+faecium&rft.au=Sung%2C+K%3BKhan%2C+S+A%3BNawaz%2C+M+S&rft.aulast=Sung&rft.aufirst=K&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Evaluation of CPC+, a New Medium for Isolation and Enumeration of Vibrio vulnificus from U.S. Market Oysters T2 - 108th General Meeting of the American Society for Microbiology AN - 41008136; 4885028 JF - 108th General Meeting of the American Society for Microbiology AU - Krantz, J A AU - Nordstrom, J L AU - Bowers, J C AU - DePaola, A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - USA KW - Oysters KW - Pathogenic bacteria KW - Vibrio vulnificus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41008136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=An+Evaluation+of+CPC%2B%2C+a+New+Medium+for+Isolation+and+Enumeration+of+Vibrio+vulnificus+from+U.S.+Market+Oysters&rft.au=Krantz%2C+J+A%3BNordstrom%2C+J+L%3BBowers%2C+J+C%3BDePaola%2C+A&rft.aulast=Krantz&rft.aufirst=J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biotransformation of Fluoroquinolones by an Escherichia coli Strain Isolated from a Municipal Wastewater Treatment Plant T2 - 108th General Meeting of the American Society for Microbiology AN - 41006295; 4883551 JF - 108th General Meeting of the American Society for Microbiology AU - Jung, C M AU - Heinze, T M AU - Strakosha, R AU - Elkins, C A AU - Sutherland, J B Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Municipal wastes KW - Wastewater treatment KW - Biotransformation KW - Fluoroquinolones KW - Strains KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41006295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Biotransformation+of+Fluoroquinolones+by+an+Escherichia+coli+Strain+Isolated+from+a+Municipal+Wastewater+Treatment+Plant&rft.au=Jung%2C+C+M%3BHeinze%2C+T+M%3BStrakosha%2C+R%3BElkins%2C+C+A%3BSutherland%2C+J+B&rft.aulast=Jung&rft.aufirst=C&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=86th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research+and+32nd+Annual+Meeting+of+the+American+Association+for+Dental+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Mouse Model to Study the Efficacy of Potential Vaccines Against ETEC Using a Bioluminescent Reporter Strain T2 - 108th General Meeting of the American Society for Microbiology AN - 41005978; 4885422 JF - 108th General Meeting of the American Society for Microbiology AU - Singh, S AU - Stibitz, S AU - Walker, R AU - Kopecko, D J AU - Osorio, M Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Vaccines KW - Animal models KW - Bioluminescence KW - Disease control KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41005978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Mouse+Model+to+Study+the+Efficacy+of+Potential+Vaccines+Against+ETEC+Using+a+Bioluminescent+Reporter+Strain&rft.au=Singh%2C+S%3BStibitz%2C+S%3BWalker%2C+R%3BKopecko%2C+D+J%3BOsorio%2C+M&rft.aulast=Singh&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improvements to I-SceI-Mediated Allelic Exchange in Bacillus anthracis T2 - 108th General Meeting of the American Society for Microbiology AN - 41005679; 4885316 JF - 108th General Meeting of the American Society for Microbiology AU - Plaut, R D AU - Stibitz, S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Virulence KW - Pathogenic bacteria KW - Bacillus anthracis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41005679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Improvements+to+I-SceI-Mediated+Allelic+Exchange+in+Bacillus+anthracis&rft.au=Plaut%2C+R+D%3BStibitz%2C+S&rft.aulast=Plaut&rft.aufirst=R&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolism of Sudan Azo Dyes by Lactobacillus acidophilus and Lactobacillus fermentum T2 - 108th General Meeting of the American Society for Microbiology AN - 41004634; 4883559 JF - 108th General Meeting of the American Society for Microbiology AU - Xu, H. AU - Heinze, T M AU - Cerniglia, C E AU - Chen, H Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Sudan KW - Azo dyes KW - Metabolism KW - Lactobacillus acidophilus KW - Lactobacillus fermentum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41004634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Metabolism+of+Sudan+Azo+Dyes+by+Lactobacillus+acidophilus+and+Lactobacillus+fermentum&rft.au=Xu%2C+H.%3BHeinze%2C+T+M%3BCerniglia%2C+C+E%3BChen%2C+H&rft.aulast=Xu&rft.aufirst=H.&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of Resveratrol with Animal-Associated Bacteria T2 - 108th General Meeting of the American Society for Microbiology AN - 41004599; 4883553 JF - 108th General Meeting of the American Society for Microbiology AU - Jung, C M AU - Heinze, T M AU - Mullis, L B AU - Sutherland, J B Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Resveratrol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41004599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Interaction+of+Resveratrol+with+Animal-Associated+Bacteria&rft.au=Jung%2C+C+M%3BHeinze%2C+T+M%3BMullis%2C+L+B%3BSutherland%2C+J+B&rft.aulast=Jung&rft.aufirst=C&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Multiplex Real-Time PCR Assay for Rapid and Simultaneous Detection of Salmonella, Shigella, and E. coli O157:H7 T2 - 108th General Meeting of the American Society for Microbiology AN - 41003763; 4885013 JF - 108th General Meeting of the American Society for Microbiology AU - Cheng, C-M AU - Lin, W AU - Van, K Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polymerase chain reaction KW - Anadromous species KW - Nucleotide sequence KW - Escherichia coli KW - Salmonella KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41003763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Novel+Multiplex+Real-Time+PCR+Assay+for+Rapid+and+Simultaneous+Detection+of+Salmonella%2C+Shigella%2C+and+E.+coli+O157%3AH7&rft.au=Cheng%2C+C-M%3BLin%2C+W%3BVan%2C+K&rft.aulast=Cheng&rft.aufirst=C-M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Methods for Bacterial Gene Identification and Characterization in Microarray Data Analysis T2 - 108th General Meeting of the American Society for Microbiology AN - 41003455; 4885701 JF - 108th General Meeting of the American Society for Microbiology AU - Zou, W AU - Chang, C-W AU - Nayak, R AU - Chen, J J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41003455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=New+Methods+for+Bacterial+Gene+Identification+and+Characterization+in+Microarray+Data+Analysis&rft.au=Zou%2C+W%3BChang%2C+C-W%3BNayak%2C+R%3BChen%2C+J+J&rft.aulast=Zou&rft.aufirst=W&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Investigation of a Seven Gene Multi-Locus Sequence Typing Scheme to Discriminate a Closely Related Collection of Salmonella T2 - 108th General Meeting of the American Society for Microbiology AN - 41001270; 4883630 JF - 108th General Meeting of the American Society for Microbiology AU - Bell, R L AU - Andrzejewski, D AU - Callahan, J H AU - Musser, S M AU - Brown, E W Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Typing KW - Anadromous species KW - Phylogeny KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41001270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=An+Investigation+of+a+Seven+Gene+Multi-Locus+Sequence+Typing+Scheme+to+Discriminate+a+Closely+Related+Collection+of+Salmonella&rft.au=Bell%2C+R+L%3BAndrzejewski%2C+D%3BCallahan%2C+J+H%3BMusser%2C+S+M%3BBrown%2C+E+W&rft.aulast=Bell&rft.aufirst=R&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Matrix Type, Enrichment Medium, and Genomic DNA Extraction Method on Real-Time PCR Inhibition and Detection of Yersinia enterocolitica from Environmental Swabs T2 - 108th General Meeting of the American Society for Microbiology AN - 41001222; 4885024 JF - 108th General Meeting of the American Society for Microbiology AU - Stewart, D AU - Laird, D AU - Reineke, K AU - Tortorello, M Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polymerase chain reaction KW - Genomics KW - Nucleotide sequence KW - Yersinia enterocolitica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41001222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.atitle=Inactivation+of+Clostridium+botulinum+Type+A+Neurotoxin+in+Milk+by+High+Pressure+Processing&rft.au=Schlesser%2C+J+E%3BGerdes%2C+R%3BSkinner%2C+G+E%3BReddy%2C+N+R%3BParisi%2C+B&rft.aulast=Schlesser&rft.aufirst=J&rft.date=2008-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+of+Animal+Science&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization by Optical Mapping of Three Archetypal Chromosomes of Escherichia coli O157:H7 Involved in Three 2006 Outbreaks Associated with Fresh Produce T2 - 108th General Meeting of the American Society for Microbiology AN - 41000659; 4885446 JF - 108th General Meeting of the American Society for Microbiology AU - Kotewicz, M L AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Gene mapping KW - Outbreaks KW - Chromosomes KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41000659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Characterization+by+Optical+Mapping+of+Three+Archetypal+Chromosomes+of+Escherichia+coli+O157%3AH7+Involved+in+Three+2006+Outbreaks+Associated+with+Fresh+Produce&rft.au=Kotewicz%2C+M+L%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Kotewicz&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of a Genotyping DNA Microarray Representing Diverse Pathotypes of E.coli and Shigella sp for Strain Identification and Discrimination between and Within Closely Related Species T2 - 108th General Meeting of the American Society for Microbiology AN - 41000565; 4884704 JF - 108th General Meeting of the American Society for Microbiology AU - Jackson, S A AU - Patel, I AU - Mammel, M K AU - Mays, T AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Discrimination KW - DNA microarrays KW - Genotyping KW - Population genetics KW - Strains KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41000565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Use+of+a+Genotyping+DNA+Microarray+Representing+Diverse+Pathotypes+of+E.coli+and+Shigella+sp+for+Strain+Identification+and+Discrimination+between+and+Within+Closely+Related+Species&rft.au=Jackson%2C+S+A%3BPatel%2C+I%3BMammel%2C+M+K%3BMays%2C+T%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Jackson&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transposon Mutagenesis Shows that Genes Other than those Associated with csgBA(C) and bcsABZC Operons can Affect the Expression of Extracellular Cellulose and Curli in Cronobacter sp. (formerly Enterobacter sakazakii) T2 - 108th General Meeting of the American Society for Microbiology AN - 41000307; 4884985 JF - 108th General Meeting of the American Society for Microbiology AU - Datta, A R AU - Tall, B D AU - Kothary, M H AU - Sathyamoorthy, V AU - Everton, K S AU - Lee, C J AU - Carter, L AU - McCardell, B A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Cellulose KW - Transposon mutagenesis KW - Operons KW - Mutagenesis KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41000307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Mechanism+of+Protection+Induced+by+a+Live+Attenuated+Matrix+Gene+%28M1%29+Mutant+Virus+Against+Homologous+and+Heterologous+Influenza+Challenges+in+Mice&rft.au=Xie%2C+Hang%3BWu%2C+Zhengqi%3BLiu%2C+Teresa%3BYe%2C+Zhiping&rft.aulast=Xie&rft.aufirst=Hang&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Antimicrobial Resistance Monitoring System (NARMS) T2 - 108th General Meeting of the American Society for Microbiology AN - 40999466; 4886299 JF - 108th General Meeting of the American Society for Microbiology AU - White, D G Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Antimicrobial agents KW - Antimicrobial resistance KW - Monitoring systems KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40999466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=National+Antimicrobial+Resistance+Monitoring+System+%28NARMS%29&rft.au=White%2C+D+G&rft.aulast=White&rft.aufirst=D&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Degradation of Ceftiofur by Bovine Fecal Bacteria T2 - 108th General Meeting of the American Society for Microbiology AN - 40999276; 4885136 JF - 108th General Meeting of the American Society for Microbiology AU - Williams, A J AU - Rafii, F AU - Park, M AU - Sims, L M AU - Jung, C M AU - Johnson, S J AU - Erickson, B D AU - Cerniglia, C E AU - Sutherland, J B Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Fecal coliforms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40999276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Degradation+of+Ceftiofur+by+Bovine+Fecal+Bacteria&rft.au=Sauder%2C+Christian%3BZhang%2C+Cheryl%3BMalik%2C+Tahir%3BDuprex%2C+Paul%3BCarbone%2C+Kathryn%3BRubin%2C+Steven&rft.aulast=Sauder&rft.aufirst=Christian&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Campylobacter jejuni 81-176 Induces Specific Phosphorylation/Dephosphorylation of Host Proteins during Invasion of Human Epithelial Cells T2 - 108th General Meeting of the American Society for Microbiology AN - 40999192; 4882754 JF - 108th General Meeting of the American Society for Microbiology AU - Hu, L. AU - Kopecko, D J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Dephosphorylation KW - Epithelial cells KW - Phosphorylation KW - Introduced species KW - Campylobacter jejuni KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40999192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Campylobacter+jejuni+81-176+Induces+Specific+Phosphorylation%2FDephosphorylation+of+Host+Proteins+during+Invasion+of+Human+Epithelial+Cells&rft.au=Hu%2C+L.%3BKopecko%2C+D+J&rft.aulast=Hu&rft.aufirst=L.&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phylogenetic Diversity of Enterobacter sakazakii as Revealed by a Five-Gene Multilocus Sequence Analysis T2 - 108th General Meeting of the American Society for Microbiology AN - 40999067; 4883635 JF - 108th General Meeting of the American Society for Microbiology AU - Ramaseshan, A S AU - Keys, C E AU - Trujillo, S AU - Lampel, K A AU - Brown, E W Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Phylogenetics KW - Species diversity KW - Nucleotide sequence KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40999067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Phylogenetic+Diversity+of+Enterobacter+sakazakii+as+Revealed+by+a+Five-Gene+Multilocus+Sequence+Analysis&rft.au=Ramaseshan%2C+A+S%3BKeys%2C+C+E%3BTrujillo%2C+S%3BLampel%2C+K+A%3BBrown%2C+E+W&rft.aulast=Ramaseshan&rft.aufirst=A&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is 16S rDNA a Reliable Phylogenetic Marker to Characterize Taxonomic Relationships of Erwinia, Brenneria, and Pectobacterium? T2 - 108th General Meeting of the American Society for Microbiology AN - 40998987; 4883625 JF - 108th General Meeting of the American Society for Microbiology AU - Naum, M AU - Brown, E W AU - Mason-Gamer, R J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - RRNA 16S KW - Phylogenetics KW - Erwinia KW - Brenneria KW - Pectobacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40998987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Is+16S+rDNA+a+Reliable+Phylogenetic+Marker+to+Characterize+Taxonomic+Relationships+of+Erwinia%2C+Brenneria%2C+and+Pectobacterium%3F&rft.au=Naum%2C+M%3BBrown%2C+E+W%3BMason-Gamer%2C+R+J&rft.aulast=Naum&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Survivability of Bacillus anthracis (Stern strain) in Processed Liquid Eggs T2 - 108th General Meeting of the American Society for Microbiology AN - 40998921; 4885032 JF - 108th General Meeting of the American Society for Microbiology AU - Khan, S A AU - Sung, K AU - Nawaz, M S AU - Cerniglia, C E AU - Kelly, L S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Eggs KW - Strains KW - Bacillus anthracis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40998921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Investigation+of+the+Contribution+of+the+Surface+and+Matrix+Proteins+of+Mumps+Virus+Strain+Urabe+AM9+to+Neurovirulence&rft.au=Link%2C+Malen+A%3BSauder%2C+Christian%3BZhang%2C+Cheryl%3BDuprex%2C+Paul%3BCarbone%2C+Kathryn+M%3BRubin%2C+Steven&rft.aulast=Link&rft.aufirst=Malen&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Method to Isolate and Enrich for Francisella tularensis, Salmonella enteritidis and Listeria monocytogenes from Foods to Facilitate Subsequent Detection by Real-Time PCR T2 - 108th General Meeting of the American Society for Microbiology AN - 40998794; 4885005 JF - 108th General Meeting of the American Society for Microbiology AU - Day, J AU - Hao, D Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polymerase chain reaction KW - Food KW - Anadromous species KW - Nucleotide sequence KW - Salmonella enteritidis KW - Francisella tularensis KW - Listeria monocytogenes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40998794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Development+of+a+Method+to+Isolate+and+Enrich+for+Francisella+tularensis%2C+Salmonella+enteritidis+and+Listeria+monocytogenes+from+Foods+to+Facilitate+Subsequent+Detection+by+Real-Time+PCR&rft.au=Day%2C+J%3BHao%2C+D&rft.aulast=Day&rft.aufirst=J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Transcriptomic Analysis of AcrA Function: The Membrane Fusion Protein of the Major Tripartite Multidrug Efflux Pump of Escherichia coli T2 - 108th General Meeting of the American Society for Microbiology AN - 40998568; 4882975 JF - 108th General Meeting of the American Society for Microbiology AU - Elkins, C A AU - Han, T AU - Mullis, L B AU - Fuscoe, J C Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Membrane proteins KW - Membrane fusion KW - Pumps KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40998568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Comparative+Transcriptomic+Analysis+of+AcrA+Function%3A+The+Membrane+Fusion+Protein+of+the+Major+Tripartite+Multidrug+Efflux+Pump+of+Escherichia+coli&rft.au=Elkins%2C+C+A%3BHan%2C+T%3BMullis%2C+L+B%3BFuscoe%2C+J+C&rft.aulast=Elkins&rft.aufirst=C&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Real-Time Multiplex PCR Assay for the Detection of Shigella in Foods T2 - 108th General Meeting of the American Society for Microbiology AN - 40997106; 4885019 JF - 108th General Meeting of the American Society for Microbiology AU - Deer, D M AU - Lampel, K A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polymerase chain reaction KW - Food KW - Nucleotide sequence KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40997106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Real-Time+Multiplex+PCR+Assay+for+the+Detection+of+Shigella+in+Foods&rft.au=Deer%2C+D+M%3BLampel%2C+K+A&rft.aulast=Deer&rft.aufirst=D&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Studies on the Fimbrial Subunit Promoters of Bordetella pertussis T2 - 108th General Meeting of the American Society for Microbiology AN - 40995864; 4884413 JF - 108th General Meeting of the American Society for Microbiology AU - Chen, Q AU - Boucher, P AU - Baxter, K AU - Hinton, D AU - Stibitz, S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Promoters KW - Pertussis KW - Bordetella pertussis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40995864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Genetic+Studies+on+the+Fimbrial+Subunit+Promoters+of+Bordetella+pertussis&rft.au=Chen%2C+Q%3BBoucher%2C+P%3BBaxter%2C+K%3BHinton%2C+D%3BStibitz%2C+S&rft.aulast=Chen&rft.aufirst=Q&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Cellulose and Curli Multicellular Behavior Morphotypes among Cronobacter sp. (formerly Enterobacter sakazakii) T2 - 108th General Meeting of the American Society for Microbiology AN - 40995493; 4884984 JF - 108th General Meeting of the American Society for Microbiology AU - Tall, B D AU - Kothary, M H AU - Everton, K S AU - McCardell, B A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Cellulose KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40995493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Expression+of+Cellulose+and+Curli+Multicellular+Behavior+Morphotypes+among+Cronobacter+sp.+%28formerly+Enterobacter+sakazakii%29&rft.au=Tall%2C+B+D%3BKothary%2C+M+H%3BEverton%2C+K+S%3BMcCardell%2C+B+A&rft.aulast=Tall&rft.aufirst=B&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Method to Isolate and Detect Shigella species from Produce Commodities T2 - 108th General Meeting of the American Society for Microbiology AN - 40995238; 4885020 JF - 108th General Meeting of the American Society for Microbiology AU - Hawkins, E AU - Tipton, A AU - Enurah, A AU - Lampel, K Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40995238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Method+to+Isolate+and+Detect+Shigella+species+from+Produce+Commodities&rft.au=Hawkins%2C+E%3BTipton%2C+A%3BEnurah%2C+A%3BLampel%2C+K&rft.aulast=Hawkins&rft.aufirst=E&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the Taxonomic Utility of Six-Enzyme Pulsed-Field Gel Electrophoresis in Reconstructing Salmonella Phylogeny T2 - 108th General Meeting of the American Society for Microbiology AN - 40994238; 4883628 JF - 108th General Meeting of the American Society for Microbiology AU - Trujillo, S AU - Keys, C E AU - Brown, E W Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Phylogeny KW - Electrophoresis KW - Pulsed-field gel electrophoresis KW - Anadromous species KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40994238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Evaluation+of+the+Taxonomic+Utility+of+Six-Enzyme+Pulsed-Field+Gel+Electrophoresis+in+Reconstructing+Salmonella+Phylogeny&rft.au=Trujillo%2C+S%3BKeys%2C+C+E%3BBrown%2C+E+W&rft.aulast=Trujillo&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Real Time PCR Method for the Detection of Yersinia enterocolitica in Green Leafy Vegetables T2 - 108th General Meeting of the American Society for Microbiology AN - 40994067; 4884595 JF - 108th General Meeting of the American Society for Microbiology AU - Rodriguez, A A AU - Regan, P M AU - Margolin, A B Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Vegetables KW - Polymerase chain reaction KW - Nucleotide sequence KW - Yersinia enterocolitica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40994067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Development+of+a+Real+Time+PCR+Method+for+the+Detection+of+Yersinia+enterocolitica+in+Green+Leafy+Vegetables&rft.au=Rodriguez%2C+A+A%3BRegan%2C+P+M%3BMargolin%2C+A+B&rft.aulast=Rodriguez&rft.aufirst=A&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Evaluation of Hepatitis A Virus Recoveries from Green Onions and Spinach Using Fluorogenic RT-PCR T2 - 108th General Meeting of the American Society for Microbiology AN - 40994066; 4885023 JF - 108th General Meeting of the American Society for Microbiology AU - Shieh, Y C AU - Laird, D T AU - Stewart, D S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Hepatitis A KW - Polymerase chain reaction KW - Hepatitis A virus KW - Spinacia oleracea KW - Allium cepa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40994066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Rapid+Evaluation+of+Hepatitis+A+Virus+Recoveries+from+Green+Onions+and+Spinach+Using+Fluorogenic+RT-PCR&rft.au=Shieh%2C+Y+C%3BLaird%2C+D+T%3BStewart%2C+D+S&rft.aulast=Shieh&rft.aufirst=Y&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Multiple Strains of Norovirus in Oysters Implicated in an Outbreak of Acute Gastroenteritis T2 - 108th General Meeting of the American Society for Microbiology AN - 40992843; 4883161 JF - 108th General Meeting of the American Society for Microbiology AU - Woods, J W Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Gastroenteritis KW - Oysters KW - Outbreaks KW - Strains KW - Norovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40992843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Detection+of+Multiple+Strains+of+Norovirus+in+Oysters+Implicated+in+an+Outbreak+of+Acute+Gastroenteritis&rft.au=Woods%2C+J+W&rft.aulast=Woods&rft.aufirst=J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Studies of Secreted Proteases of Bacillus anthracis T2 - 108th General Meeting of the American Society for Microbiology AN - 40991834; 4885832 JF - 108th General Meeting of the American Society for Microbiology AU - McNichol, B A AU - Grippe, V K AU - Lee, G M AU - Merkel, T J AU - Stibitz, S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Proteinase KW - Bacillus anthracis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40991834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Genetic+Studies+of+Secreted+Proteases+of+Bacillus+anthracis&rft.au=McNichol%2C+B+A%3BGrippe%2C+V+K%3BLee%2C+G+M%3BMerkel%2C+T+J%3BStibitz%2C+S&rft.aulast=McNichol&rft.aufirst=B&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of Biological Enrichment in Mammalian Cell Culture to Increase the Sensitivity of Mycoplasma Detection by Molecular Methods T2 - 108th General Meeting of the American Society for Microbiology AN - 40991536; 4884835 JF - 108th General Meeting of the American Society for Microbiology AU - Kong, H AU - Volokhov, D V AU - George, J AU - Anderson, C AU - Chizhikov, V E Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Cell culture KW - Mammalian cells KW - Mycoplasma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40991536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=The+Use+of+Biological+Enrichment+in+Mammalian+Cell+Culture+to+Increase+the+Sensitivity+of+Mycoplasma+Detection+by+Molecular+Methods&rft.au=Kong%2C+H%3BVolokhov%2C+D+V%3BGeorge%2C+J%3BAnderson%2C+C%3BChizhikov%2C+V+E&rft.aulast=Kong&rft.aufirst=H&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phenotypic Microarray of Escherichia coli O157:H7 Isolates from the 2006 Outbreaks Linked to Fresh Produce T2 - 108th General Meeting of the American Society for Microbiology AN - 40990380; 4884607 JF - 108th General Meeting of the American Society for Microbiology AU - Mukherjee, A AU - Mammel, M K AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Outbreaks KW - Phenotypes KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40990380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Phenotypic+Microarray+of+Escherichia+coli+O157%3AH7+Isolates+from+the+2006+Outbreaks+Linked+to+Fresh+Produce&rft.au=Mukherjee%2C+A%3BMammel%2C+M+K%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Mukherjee&rft.aufirst=A&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phenotypic and Genotypic Characterization of Escherichia coli O157:H7 Isolates from 2006 Outbreaks Linked to Fresh Produce T2 - 108th General Meeting of the American Society for Microbiology AN - 40990333; 4884605 JF - 108th General Meeting of the American Society for Microbiology AU - Li, B. AU - Gebru, S AU - George, G L AU - Roberson, D AU - Lacher, D W AU - Kotewicz, M L AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Outbreaks KW - Phenotypes KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40990333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Phenotypic+and+Genotypic+Characterization+of+Escherichia+coli+O157%3AH7+Isolates+from+2006+Outbreaks+Linked+to+Fresh+Produce&rft.au=Li%2C+B.%3BGebru%2C+S%3BGeorge%2C+G+L%3BRoberson%2C+D%3BLacher%2C+D+W%3BKotewicz%2C+M+L%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Li&rft.aufirst=B.&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Campylobacter jejuni 81-176 Requires Lipid Rafts and Glycosylphosphatidylinositol (GPI)-Anchored Proteins for Human Epithelial Cell Adherence and Invasion T2 - 108th General Meeting of the American Society for Microbiology AN - 40989408; 4883254 JF - 108th General Meeting of the American Society for Microbiology AU - Shima, K AU - Giri, C P AU - Guerry, P AU - Kopecko, D J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Lipid rafts KW - Glycosylphosphatidylinositol KW - Epithelial cells KW - Campylobacter jejuni KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40989408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Campylobacter+jejuni+81-176+Requires+Lipid+Rafts+and+Glycosylphosphatidylinositol+%28GPI%29-Anchored+Proteins+for+Human+Epithelial+Cell+Adherence+and+Invasion&rft.au=Shima%2C+K%3BGiri%2C+C+P%3BGuerry%2C+P%3BKopecko%2C+D+J&rft.aulast=Shima&rft.aufirst=K&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of LC-MS Technology and Other Novel Subtyping Strategies to Detect Clusters of Foodborne Pathogenic Strains T2 - 108th General Meeting of the American Society for Microbiology AN - 40988773; 4886443 JF - 108th General Meeting of the American Society for Microbiology AU - Brown, E Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Technology KW - Food KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40988773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=The+Use+of+LC-MS+Technology+and+Other+Novel+Subtyping+Strategies+to+Detect+Clusters+of+Foodborne+Pathogenic+Strains&rft.au=Brown%2C+E&rft.aulast=Brown&rft.aufirst=E&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic Analysis of Polycyclic Aromatic Hydrocarbon Degradation in Mycobacterium vanbaalenii PYR-1 T2 - 108th General Meeting of the American Society for Microbiology AN - 40988426; 4884135 JF - 108th General Meeting of the American Society for Microbiology AU - Kim, S-J AU - Kweon, O-G AU - Jones, R C AU - Edmondson, R D AU - Cerniglia, C E Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polycyclic aromatic hydrocarbons KW - Genomic analysis KW - Aromatic hydrocarbons KW - Mycobacterium vanbaalenii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40988426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Genomic+Analysis+of+Polycyclic+Aromatic+Hydrocarbon+Degradation+in+Mycobacterium+vanbaalenii+PYR-1&rft.au=Kim%2C+S-J%3BKweon%2C+O-G%3BJones%2C+R+C%3BEdmondson%2C+R+D%3BCerniglia%2C+C+E&rft.aulast=Kim&rft.aufirst=S-J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vibrio cholerae O139 O-Antigen Gene Locus Requires Adjacent Group 4 Capsule Secretion Genes for Biosynthesis of Capsule, but Not LPS T2 - 108th General Meeting of the American Society for Microbiology AN - 40988088; 4883403 JF - 108th General Meeting of the American Society for Microbiology AU - Xu, D-Q AU - Johnson, J A AU - Kopecko, D J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Biosynthesis KW - Secretion KW - Lipopolysaccharides KW - Vibrio cholerae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40988088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Vibrio+cholerae+O139+O-Antigen+Gene+Locus+Requires+Adjacent+Group+4+Capsule+Secretion+Genes+for+Biosynthesis+of+Capsule%2C+but+Not+LPS&rft.au=Xu%2C+D-Q%3BJohnson%2C+J+A%3BKopecko%2C+D+J&rft.aulast=Xu&rft.aufirst=D-Q&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation and Molecular Characterization of Tetracycline-Resistant Escherichia coli Isolated from Catfish T2 - 108th General Meeting of the American Society for Microbiology AN - 40987419; 4884584 JF - 108th General Meeting of the American Society for Microbiology AU - Nawaz, M S AU - Khan, A A AU - Khan, S A AU - Sung, K AU - Steele, R S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Pathogens KW - Food KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40987419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Isolation+and+Molecular+Characterization+of+Tetracycline-Resistant+Escherichia+coli+Isolated+from+Catfish&rft.au=Nawaz%2C+M+S%3BKhan%2C+A+A%3BKhan%2C+S+A%3BSung%2C+K%3BSteele%2C+R+S&rft.aulast=Nawaz&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Characterization of Class 1 Integron Resistance Genes Cassettes among Salmonella Strains from Imported Seafood T2 - 108th General Meeting of the American Society for Microbiology AN - 40986681; 4884567 JF - 108th General Meeting of the American Society for Microbiology AU - Khan, A A AU - Ponce, E AU - Cheng, C-M AU - Nawaz, M AU - Summage-West, C Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Seafood KW - Anadromous species KW - Strains KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40986681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Language+Learning+and+Development&rft.atitle=Is+Infants%27+Learning+of+Sound+Patterns+Constrained+by+Phonological+Features%3F&rft.au=Cristi%C3%A1%2C+Alejandrina%3BSeidl%2C+Amanda&rft.aulast=Cristi%C3%A1&rft.aufirst=Alejandrina&rft.date=2008-07-01&rft.volume=4&rft.issue=3&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Language+Learning+and+Development&rft.issn=15475441&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Genomic Evaluation of Listeria monocytogenes Strains Involved in Invasive and Gastroenteritis Listeriosis Outbreaks T2 - 108th General Meeting of the American Society for Microbiology AN - 40986259; 4884114 JF - 108th General Meeting of the American Society for Microbiology AU - Burall, L S AU - Datta, A R Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Gastroenteritis KW - Outbreaks KW - Listeriosis KW - Genomics KW - Strains KW - Listeria monocytogenes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40986259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Comparative+Genomic+Evaluation+of+Listeria+monocytogenes+Strains+Involved+in+Invasive+and+Gastroenteritis+Listeriosis+Outbreaks&rft.au=Burall%2C+L+S%3BDatta%2C+A+R&rft.aulast=Burall&rft.aufirst=L&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevelance and Distribution of Noro- and Hepatitis A Viruses (HAV) in U.S. Market Shellfish T2 - 108th General Meeting of the American Society for Microbiology AN - 40986256; 4883160 JF - 108th General Meeting of the American Society for Microbiology AU - Burkhardt III, W AU - Calci, K AU - Williams-Hill, D AU - Tran, N AU - Thammasouk, K AU - Wetherington, J AU - Kasturi, K AU - Herbst, T AU - Lara, A AU - Williams, J AU - Kaewussdangkul, P AU - Romero, H AU - Jacobs, E AU - Patton, L AU - Swinford, A G AU - Woods, J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - USA KW - Hepatitis A KW - Shellfish KW - Viruses KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40986256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Prevelance+and+Distribution+of+Noro-+and+Hepatitis+A+Viruses+%28HAV%29+in+U.S.+Market+Shellfish&rft.au=Simmons%2C+Janine+M%3BSaad%2C+Ziad+S%3BLizak%2C+Martin+J%3BOrtiz%2C+Michael%3BKoretsky%2C+Alan+P%3BRichmond%2C+Barry+J&rft.aulast=Simmons&rft.aufirst=Janine&rft.date=2008-07-23&rft.volume=28&rft.issue=30&rft.spage=7637&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.1488-08.2008 L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Design and Development of a Novel High Density Microarray Representative of Over 75 Complete Genome Sequences of Salmonella and Escherichia coli: Identifying Genes and SNPs T2 - 108th General Meeting of the American Society for Microbiology AN - 40985711; 4884701 JF - 108th General Meeting of the American Society for Microbiology AU - Jackson, S A AU - Mammel, M AU - Patel, I AU - LeClerc, J E AU - Cebula, T A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Genomes KW - Single-nucleotide polymorphism KW - Anadromous species KW - Escherichia coli KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40985711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Design+and+Development+of+a+Novel+High+Density+Microarray+Representative+of+Over+75+Complete+Genome+Sequences+of+Salmonella+and+Escherichia+coli%3A+Identifying+Genes+and+SNPs&rft.au=Jackson%2C+S+A%3BMammel%2C+M%3BPatel%2C+I%3BLeClerc%2C+J+E%3BCebula%2C+T+A&rft.aulast=Jackson&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recommendations for a Revised System of Nomenclature for Allelic Variants of Intimin (eae) T2 - 108th General Meeting of the American Society for Microbiology AN - 40985630; 4884688 JF - 108th General Meeting of the American Society for Microbiology AU - Lacher, D AU - Steinsland, H AU - Whittam, T Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Experimental allergic encephalomyelitis KW - Nomenclature KW - Intimin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40985630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Recommendations+for+a+Revised+System+of+Nomenclature+for+Allelic+Variants+of+Intimin+%28eae%29&rft.au=Lacher%2C+D%3BSteinsland%2C+H%3BWhittam%2C+T&rft.aulast=Lacher&rft.aufirst=D&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning and Partial Characterization of a Novel Vibrio tubiashii Hemolysin Gene and the Development of a PCR Based Detection for V. tubiashii T2 - 108th General Meeting of the American Society for Microbiology AN - 40985497; 4884602 JF - 108th General Meeting of the American Society for Microbiology AU - Sathyamoorthy, V AU - Datta, A R AU - Lee, C J AU - Tall, B D AU - McCardell, B A AU - Kothary, M H Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polymerase chain reaction KW - Hemolysin KW - Disease detection KW - Nucleotide sequence KW - Vibrio tubiashii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40985497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Cloning+and+Partial+Characterization+of+a+Novel+Vibrio+tubiashii+Hemolysin+Gene+and+the+Development+of+a+PCR+Based+Detection+for+V.+tubiashii&rft.au=Sathyamoorthy%2C+V%3BDatta%2C+A+R%3BLee%2C+C+J%3BTall%2C+B+D%3BMcCardell%2C+B+A%3BKothary%2C+M+H&rft.aulast=Sathyamoorthy&rft.aufirst=V&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Function and Expression of the hmu Heme Transport System in Corynebacterium Species T2 - 108th General Meeting of the American Society for Microbiology AN - 40984829; 4884294 JF - 108th General Meeting of the American Society for Microbiology AU - Schmitt, M P AU - Allen, C E AU - Kunkle, C A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Heme KW - Corynebacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40984829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Function+and+Expression+of+the+hmu+Heme+Transport+System+in+Corynebacterium+Species&rft.au=Schmitt%2C+M+P%3BAllen%2C+C+E%3BKunkle%2C+C+A&rft.aulast=Schmitt&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of Vibrio parahaemolyticus and V. vulnificus Levels in U.S. Market Oysters T2 - 108th General Meeting of the American Society for Microbiology AN - 40984657; 4884591 JF - 108th General Meeting of the American Society for Microbiology AU - Nordstrom, J L AU - Bowers, J C AU - Krantz, J A AU - Calci, K R AU - Byars, R AU - Johnson, J AU - Kasturi, K AU - Kawalek, M AU - Gonzalez, E AU - Obando, J AU - Versace, J AU - Phan, L AU - Thammasouk, K AU - Eliasberg, S AU - Chatman, L AU - Welch, J AU - DePaola, A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - USA KW - Oysters KW - Pathogenic bacteria KW - Vibrio parahaemolyticus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40984657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Distribution+of+Vibrio+parahaemolyticus+and+V.+vulnificus+Levels+in+U.S.+Market+Oysters&rft.au=Nordstrom%2C+J+L%3BBowers%2C+J+C%3BKrantz%2C+J+A%3BCalci%2C+K+R%3BByars%2C+R%3BJohnson%2C+J%3BKasturi%2C+K%3BKawalek%2C+M%3BGonzalez%2C+E%3BObando%2C+J%3BVersace%2C+J%3BPhan%2C+L%3BThammasouk%2C+K%3BEliasberg%2C+S%3BChatman%2C+L%3BWelch%2C+J%3BDePaola%2C+A&rft.aulast=Nordstrom&rft.aufirst=J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variation in the Effect of Exposure to Gatifloxacin on the Metabolic Activities of different Strains of Clostridium perfringens T2 - 108th General Meeting of the American Society for Microbiology AN - 40984056; 4884250 JF - 108th General Meeting of the American Society for Microbiology AU - Rafii, F AU - Park, M AU - Costa, G. Gamboa da Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Gatifloxacin KW - Strains KW - Clostridium perfringens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40984056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Variation+in+the+Effect+of+Exposure+to+Gatifloxacin+on+the+Metabolic+Activities+of+different+Strains+of+Clostridium+perfringens&rft.au=Rafii%2C+F%3BPark%2C+M%3BCosta%2C+G.+Gamboa+da&rft.aulast=Rafii&rft.aufirst=F&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Practice-specific risk perceptions and self-reported food safety practices AN - 37079717; 3834855 AB - The relationship between risk perception and risk avoidance is typically analyzed using self-reported measures. However, in domains such as driving or food handling, the validity of responses about usual behavior is threatened because people think about the situations in which they are self-aware, such as when they encounter a hazard. Indeed, researchers have often noted a divergence between what people say about their behavior and how they actually behave. Thus, in order to draw conclusions about risk perceptions and risk avoidance from survey data, it is important to identify particular cognitive elements, such as those measured by questions about risk and safety knowledge, risk perceptions, or information search behavior, which may be effective antecedents of self-reported safety behavior. It is also important to identify and correct for potential sources of bias that may exist in the data. The authors analyze the Food and Drug Administration's 1998 Food Safety Survey to determine whether there are consistent cognitive antecedents for three types of safe food practices: preparation, eating, and cooling of foods. An assessment of measurement biases shows that endogeneity of food choices affects reports of food preparation. In addition, response bias affects reports of cooling practices as evidenced by its relation to knowledge and information search, a pattern of cognitive effects unique to cooling practices. After correcting for these biases, results show that practice-specific risk perceptions are the primary cognitive antecedents of safe food behavior, which has implications for the design of effective education messages about food safety. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Levy, Alan S AU - Choinière, Conrad J AU - Fein, Sara B AD - U.S. Food and Drug Administration Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 749 EP - 762 VL - 28 IS - 3 SN - 0272-4332, 0272-4332 KW - Sociology KW - Risk management KW - Measurement KW - Medical sociology KW - Food KW - Health education KW - Social perception KW - Surveys KW - Food safety KW - Human behaviour KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37079717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=Practice-specific+risk+perceptions+and+self-reported+food+safety+practices&rft.au=Levy%2C+Alan+S%3BChoini%C3%A8re%2C+Conrad+J%3BFein%2C+Sara+B&rft.aulast=Levy&rft.aufirst=Alan&rft.date=2008-06-01&rft.volume=28&rft.issue=3&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2008.01051.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5142 10449 5772; 7854; 6071 1542 11325; 7887 12008; 11883 9382; 12429; 10449 5772; 5779 4049; 5114; 11038 7625 DO - http://dx.doi.org/10.1111/j.1539-6924.2008.01051.x ER - TY - JOUR T1 - Executive and Attention Functioning Among Children in the PANDAS Subgroup AN - 21124016; 11153714 AB - Evidence from past studies indicates that adults and children with Obsessive-Compulsive Disorder (OCD) and Tourette syndrome (TS) experience subtle neuropsychological deficits. Less is known about neuropsychological functioning of children and adolescents with a symptom course consistent with the PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection) subgroup of OCD and tics. To provide such information, we administered three tests of attention control and two of executive function to 67 children and adolescents (ages 5-16) diagnosed with OCD and/or tics and a symptom course consistent with the PANDAS subgroup and 98 healthy volunteers (HV) matched by age, sex, and IQ. In a paired comparison of the two groups, the PANDAS subjects were less accurate than HV in a test of response suppression. Further, in a two-step linear regression analysis of the PANDAS group in which clinical variables were added stepwise into the model and in the second step matching variables (age, sex, and IQ) were added, IQ emerged as a predictor of performance on this task. In the same analysis, ADHD diagnosis and age emerged as predictors of response time in a continuous performance task. Subdividing the PANDAS group by primary psychiatric diagnosis revealed that subjects with TS or OCD with tics exhibited a longer response time compared to controls than subjects with OCD only, replicating previous findings within TS and OCD. This study demonstrates that children with PANDAS exhibit neuropsychological profiles similar to those of their primary psychiatric diagnosis. JF - Neuropsychology, Development, and Cognition. Section C: Child Neuropsychology AU - Hirschtritt, Matthew AU - Hammond, Christopher AU - Luckenbaugh, David AU - Buhle, Jason AU - Thurm, Audrey AU - Casey, B J AU - Swedo, Susan AD - Department of Health and Human Services, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA,Johns Hopkins University, Baltimore, Maryland, USA Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 179 EP - 194 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 15 IS - 2 SN - 0929-7049, 0929-7049 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts; Immunology Abstracts KW - Streptococcus KW - Age KW - Pediatrics KW - Adolescence KW - Infection KW - Children KW - Cognition KW - Executive function KW - Intelligence KW - Mental disorders KW - Regression analysis KW - Obsessive compulsive disorder KW - Gilles de la Tourette syndrome KW - Sex KW - N3 11001:Behavioral and Cognitive Neuroscience KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21124016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Structural+stabilization+in+tetrameric+or+polymeric+hemoglobin+determines+its+interaction+with+endogenous+antioxidant+scavenger+pathways.&rft.au=Buehler%2C+Paul+W%3BVallelian%2C+Florence%3BMikolajczyk%2C+Malgorzata+G%3BSchoedon%2C+Gabriele%3BSchweizer%2C+Thomas%3BAlayash%2C+Abdu+I%3BSchaer%2C+Dominik+J&rft.aulast=Buehler&rft.aufirst=Paul&rft.date=2008-08-01&rft.volume=10&rft.issue=8&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=1557-7716&rft_id=info:doi/10.1089%2Fars.2008.2028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Pediatrics; Adolescence; Children; Infection; Cognition; Executive function; Intelligence; Mental disorders; Regression analysis; Obsessive compulsive disorder; Gilles de la Tourette syndrome; Sex; Streptococcus DO - http://dx.doi.org/10.1080/09297040802186899 ER - TY - JOUR T1 - In vitro acetylcholinesterase inhibition and cytotoxic effect of some organophosphorus pesticides in human erythrocytes and HepG2 cells AN - 20944950; 8508039 AB - In vitro effects of some novel organophosphates like RPR-II, RPR-V, chlorpyrifos, dimethoate and monocrotophos (MCP) were studied in human erythrocytes with special reference to acetylcholinesterase (AChE) and mitochondrial function (MTT assay) in HepG2 cell lines. The purpose of the present study was to quantify "in vitro" effect by means of the 50 percent inhibition (IC sub(50) using acetylthiocholine iodide as substrate in human RBC in the presence of different concentrations of pesticides. Our study indicated dose dependent AChE inhibition by all the OP compounds tested. The IC sub(50) observed for RPR-II, RPR-V and chlorpyrifos was greater than 10 mM, whereas dimethoate and MCP showed 1.60 and 2.38 mM respectively showing dimethoate 1.48 times more potent than MCP. The kinetic constant (Vmax and Km) showed the trend of decreasing with all the compounds assayed indicating non-competative inhibition. Similarly, the cell viability (MTT) also decreased by all the tested five OP compounds. RPR-II and RPR-V were found to be least toxic and IC sub(50) observed was greater than 10 mM, whereas IC sub(50) observed for chlorpyrifos, dimethoate and MCP were 0.835, 0.850 and 0.576 mM respectively. These results indicated dose dependent cytotoxic effect by all these OP compounds on HepG2 cell lines and relatively MCP was most potent in comparison to other compounds tested. From the present study, it can be concluded that the in vitro AChE and MTT assays are sensitive assays and can be used as biochemical marker for the exposure of organophosphates. JF - Toxicology International AU - Rahman, M F AU - Mahboob, M AU - Grover, P AD - Division of Neurotoxicology, HFT-132, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas - 72079, USA, rahman1030@gmail.com Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 49 EP - 55 VL - 15 IS - 1 SN - 0971-6580, 0971-6580 KW - Toxicology Abstracts KW - Chlorpyrifos KW - Pesticides (organophosphorus) KW - Cytotoxicity KW - Biochemical markers KW - Acetylcholinesterase KW - Kinetics KW - Erythrocytes KW - monocrotophos KW - Mitochondria KW - Dimethoate KW - organophosphates KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20944950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+International&rft.atitle=In+vitro+acetylcholinesterase+inhibition+and+cytotoxic+effect+of+some+organophosphorus+pesticides+in+human+erythrocytes+and+HepG2+cells&rft.au=Rahman%2C+M+F%3BMahboob%2C+M%3BGrover%2C+P&rft.aulast=Rahman&rft.aufirst=M&rft.date=2008-06-01&rft.volume=15&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Toxicology+International&rft.issn=09716580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chlorpyrifos; Pesticides (organophosphorus); Biochemical markers; Cytotoxicity; Acetylcholinesterase; Kinetics; Erythrocytes; monocrotophos; Mitochondria; organophosphates; Dimethoate ER - TY - JOUR T1 - Targeting IL-13Ra2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin AN - 20915767; 8340916 AB - We have shown previously that high-affinity receptors for interleukin-13 (IL-13Ra2) are overexpressed on a variety of solid cancer cells, diseased fibroblasts, and other cells, and a chimeric fusion protein composed of human IL-13 and mutated Pseudomonas exotoxin (IL-13-PE38) is highly and specifically cytotoxic to these cells in vitro and in vivo. To improve the specificity for the target, we isolated specific antibodies against IL-13Ra2 from human single-chain Fv (scFv) antibody phage library and developed immunotoxin by selecting two high-affinity clones of scFv and fused to PE. The fusion chimeric gene was expressed in Escherichia coli, and highly purified IL-13R-specific immunotoxin, termed anti-IL-13Ra2(scFv)-PE38, was tested for its cytotoxicity. This molecule was highly cytotoxic to U251 glioma and PM-RCC renal cell carcinoma cell lines in vitro. The cytotoxic activity was neutralized by purified extracellular domain of IL-13Ra2 but not by IL-13, indicating that cytotoxic activity is specific. Anti-IL-13Ra2(scFv)-PE38 showed significant antitumor activity in immunodeficient mice with s.c. glioma tumors. Both i.p. and i.t. routes of administration showed antitumor activity in a dose-dependent manner. The maximum tolerated dose of anti-IL-13Ra2(scFv)-PE38 was 200 kg/kg i.p. twice daily for 5 days. These results indicate that anti-IL-13Ra2(scFv)-PE38 is a highly selective therapeutic agent for cancer therapy and should be further tested in animal models of human cancer. [Mol Cancer Ther 2008; 7(6):1579-87] JF - Molecular Cancer Therapeutics AU - Kioi, Mitomu AU - Seetharam, Saraswathy AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1579 EP - 1587 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 7 IS - 6 SN - 1535-7163, 1535-7163 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Phages KW - Animal models KW - Immunodeficiency KW - Pseudomonas KW - Tumors KW - Fv KW - Exotoxins KW - Immunotoxins KW - Fibroblasts KW - Brain tumors KW - Tumor cell lines KW - Interleukin 13 KW - Antibodies KW - Cytotoxicity KW - renal cell carcinoma KW - Gene fusion KW - Escherichia coli KW - Glioma KW - Fusion protein KW - Antitumor activity KW - J 02410:Animal Diseases KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20915767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Targeting+IL-13Ra2-positive+cancer+with+a+novel+recombinant+immunotoxin+composed+of+a+single-chain+antibody+and+mutated+Pseudomonas+exotoxin&rft.au=Kioi%2C+Mitomu%3BSeetharam%2C+Saraswathy%3BPuri%2C+Raj+K&rft.aulast=Kioi&rft.aufirst=Mitomu&rft.date=2008-06-01&rft.volume=7&rft.issue=6&rft.spage=1579&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phages; Immunodeficiency; Animal models; Tumors; Immunotoxins; Exotoxins; Fv; Fibroblasts; Brain tumors; Cytotoxicity; Antibodies; Interleukin 13; Tumor cell lines; renal cell carcinoma; Gene fusion; Fusion protein; Glioma; Antitumor activity; Escherichia coli; Pseudomonas ER - TY - JOUR T1 - Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercle AN - 20890100; 8308959 AB - Rationale: Behavioral and anatomical data suggest that the ventral striatum, consisting of the nucleus accumbens and olfactory tubercle, is functionally heterogeneous. Cocaine and d-amphetamine appear to be more rewarding when administered into the medial olfactory tubercle or medial accumbens shell than into their lateral counterparts, including the accumbens core. Objectives: We sought to determine whether rats self-administer the popular recreational drug ( plus or minus )-3,4-methylenedioxymethamphetamine (MDMA) into ventrostriatal subregions and whether the medial olfactory tubercle and medial accumbens shell mediate MDMA's positive reinforcing effects more effectively than their lateral counterparts. Results: Rats receiving 30 mM MDMA into the medial olfactory tubercle, medial accumbens shell, or accumbens core, but not the lateral tubercle or lateral shell, showed higher self-administration rates than rats receiving vehicle. The medial shell supported more vigorous self-administration of MDMA at higher concentrations than the core or medial olfactory tubercle. In addition, intra-medial shell MDMA self-administration was disrupted by co-administration of the D1 or D2 receptor antagonists SCH 23390 (1-3 mM) or raclopride (3-10 mM). Conclusions: Our data suggest that the ventral striatum is functionally heterogeneous. The medial accumbens shell appears to be more important than other ventrostriatal subregions in mediating the positive reinforcing effects of MDMA via both D1- and D2-type receptors. Together with previous data, our data also suggest that unidentified actions of MDMA interfere with the positive reinforcing effects of dopamine in the medial olfactory tubercle. JF - Psychopharmacology AU - Shin, Rick AU - Qin, Mei AU - Liu, Zhong-Hua AU - Ikemoto, Satoshi AD - US Department of Health and Human Services, 251 Bayview Boulevard, Room 08A711, Baltimore, MD, 21224, USA, sikemoto@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 261 EP - 270 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 198 IS - 2 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Dopamine D2 receptors KW - Nucleus accumbens KW - raclopride KW - Dopamine D1 receptors KW - Drug abuse KW - MDMA KW - Olfactory bulb KW - Antagonists KW - Neostriatum KW - Amphetamine KW - Cocaine KW - Drug self-administration KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20890100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Intracranial+self-administration+of+MDMA+into+the+ventral+striatum+of+the+rat%3A+differential+roles+of+the+nucleus+accumbens+shell%2C+core%2C+and+olfactory+tubercle&rft.au=Shin%2C+Rick%3BQin%2C+Mei%3BLiu%2C+Zhong-Hua%3BIkemoto%2C+Satoshi&rft.aulast=Shin&rft.aufirst=Rick&rft.date=2008-06-01&rft.volume=198&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Nucleus accumbens; raclopride; Neostriatum; Dopamine D1 receptors; Amphetamine; Drug abuse; Cocaine; MDMA; Antagonists; Olfactory bulb; Drug self-administration DO - http://dx.doi.org/10.1007/s00213-008-1131-x ER - TY - JOUR T1 - Anthrax Lethal Toxin Enhances TNF-Induced Endothelial VCAM-1 Expression via an IFN Regulatory Factor-1-Dependent Mechanism AN - 20825763; 8303160 AB - Impaired host defenses and vascular dysfunction are hallmarks of the late, antibiotic-refractory stages of systemic anthrax infection. Anthrax lethal toxin (LT), a key virulence factor of Bacillus anthracis, was previously shown to enhance VCAM-1 expression on primary human endothelial cells suggesting a causative link between dysregulated adhesion molecule expression and the poor immune response and vasculitis associated with anthrax. In this study, we report that LT amplification of TNF-induced VCAM-1 expression is driven transcriptionally by the cooperative activation of NF-B and IFN regulatory factor-1 (IRF-1). LT enhancement of NF-B phosphorylation and nuclear translocation correlated temporally with a delayed reaccumulation of IBa, while increased induction of IRF-1 was linked to STAT1 activation. LT failed to augment TNF-induced ICAM-1 or E-selectin expression, two adhesion molecules regulated by NF-B, but not IRF-1. These results suggest that LT can differentially modulate NF-B target genes and highlight the importance of IRF-1 in VCAM-1 enhancement. Altering the activity of key transcription factors involved in host response to infection may be a critical mechanism by which LT contributes to anthrax pathogenesis. JF - Journal of Immunology AU - Warfel, Jason M AU - D'Agnillo, Felice AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20057 Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 7516 EP - 7524 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 11 SN - 0022-1767, 0022-1767 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Anthrax lethal toxin KW - Vasculitis KW - virulence factors KW - Bacillus anthracis KW - Infection KW - Endothelial cells KW - Interferon KW - Nuclear transport KW - vascular cell adhesion molecule 1 KW - Phosphorylation KW - Stat1 protein KW - Transcription factors KW - NF-B protein KW - Interferon regulatory factor 1 KW - intercellular adhesion molecule 1 KW - Anthrax KW - Immune response KW - E-selectin KW - Cell adhesion molecules KW - Vascular system KW - X 24370:Natural Toxins KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20825763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Anthrax+Lethal+Toxin+Enhances+TNF-Induced+Endothelial+VCAM-1+Expression+via+an+IFN+Regulatory+Factor-1-Dependent+Mechanism&rft.au=Warfel%2C+Jason+M%3BD%27Agnillo%2C+Felice&rft.aulast=Warfel&rft.aufirst=Jason&rft.date=2008-06-01&rft.volume=180&rft.issue=11&rft.spage=7516&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; Vasculitis; virulence factors; Infection; Endothelial cells; vascular cell adhesion molecule 1; Nuclear transport; Interferon; Phosphorylation; Stat1 protein; Transcription factors; intercellular adhesion molecule 1; Interferon regulatory factor 1; NF-B protein; Anthrax; Immune response; Cell adhesion molecules; E-selectin; Vascular system; Bacillus anthracis ER - TY - JOUR T1 - An interlaboratory study of perfluorinated alkyl compound levels in human plasma AN - 20823364; 8257686 AB - We conducted an interlaboratory study which differed from the typical study of this type because of its emphasis on comparing intralaboratory variability in results. We sent specimens to six laboratories experienced in the analysis of perfluorinated alkyl compounds in blood matrices and that use stringent procedures to control and assure accuracy and precision. Each received an identical set of 60 plasma specimens that were analyzed in six completely independent batches. Split specimens were included so that within- and between-batch coefficients of variation could be calculated. All laboratories used liquid chromatography-tandem mass spectrometry (LC-MS/MS). The concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS) measured in the specimens in general showed a high level of agreement, although in some cases the agreement was only moderate. The average within- and between-batch coefficient of variation for PFOS was 9.1% and 9.3%; for PFOA was 14.5% and 14.5%; and for PFHxS was 14.5% and 17.0%. The recent availability of labeled internal standards, among other advances, has facilitated improvement in the accuracy and precision of the assays. Considering the degree of between-subject variation in levels among people in background-exposed populations, the results indicate that biomarker-based epidemiologic studies of associations with health could have reasonable precision. JF - Environmental Research AU - Longnecker, M P AU - Smith, C S AU - Kissling, GE AU - Hoppin, JA AU - Butenhoff, J L AU - Decker, E AU - Ehresman, D J AU - Ellefson, ME AU - Flaherty, J AU - Gardner AU - Langlois, E AU - LeBlanc, A AU - Lindstrom, AB AU - Reagen, W K AU - Strynar, MJ AU - Studabaker, W B AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA, longnec1@niehs.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 152 EP - 159 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 107 IS - 2 SN - 0013-9351, 0013-9351 KW - Toxicology Abstracts KW - Blood KW - Mass spectroscopy KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20823364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=An+interlaboratory+study+of+perfluorinated+alkyl+compound+levels+in+human+plasma&rft.au=Longnecker%2C+M+P%3BSmith%2C+C+S%3BKissling%2C+GE%3BHoppin%2C+JA%3BButenhoff%2C+J+L%3BDecker%2C+E%3BEhresman%2C+D+J%3BEllefson%2C+ME%3BFlaherty%2C+J%3BGardner%3BLanglois%2C+E%3BLeBlanc%2C+A%3BLindstrom%2C+AB%3BReagen%2C+W+K%3BStrynar%2C+MJ%3BStudabaker%2C+W+B&rft.aulast=Longnecker&rft.aufirst=M&rft.date=2008-06-01&rft.volume=107&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2008.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Blood; Mass spectroscopy DO - http://dx.doi.org/10.1016/j.envres.2008.01.005 ER - TY - JOUR T1 - Age and gender affect DNMT3a and DNMT3b expression in human liver AN - 20688943; 8161705 AB - DNA methylation is catalyzed by a family of DNA methyltransferases (DNMTs) including the maintenance enzyme DNMT 1 and de novo methyltransferases DNMT 3a and DNMT 3b. Elevated levels of DNMTs have been found in cancer cells and in several types of human tumors. A polymorphism found in DNMT3b has been associated with increased risk for several cancers. The factors influencing DNMT expression in human tissues have not been clearly determined. he present study examined TDNMT3a and DNMT3b levels in human liver tissue samples and compared the effect of ageing, cigarette smoking, and gender. DNMT3a and DNMT3b expression levels in the samples from older individuals (56-78 years, n = 28) were both significantly higher than those of the younger group (16-48 years, n = 27) (73.2 plus or minus 3.4 vs 8.3 plus or minus 2.8 and 56.1 plus or minus 1.9 vs 17.5 plus or minus 5.7, respectively; p < 0.05). Levels of DNMT3b in females were significantly higher than those in males (75.4 plus or minus 2.2 vs 16.3 plus or minus 4.7; p < 0.05); however, DNMT3a levels were similar for females and males (52.7 plus or minus 2.7 vs 48.4 plus or minus 2.0). Expression levels of DNMT3a and DNMT3b were similar in smokers and nonsmokers (58.1 plus or minus 3.5 vs 60.8 plus or minus 3.1 and 54.5 plus or minus 2.3 vs 48.3 plus or minus 1.8, respectively). Genotyping for DNMT3b (C arrow right T) variant in this sample pool showed a frequency distribution of CC (41%), CT (50%), and TT (9%). The findings from this study suggest that ageing and gender may be important factors influencing DNA methylation status. JF - Cell Biology and Toxicology AU - Xiao, Yongmei AU - Word, Beverly AU - Starlard-Davenport, Atena AU - Haefele, Aaron AU - Lyn-Cook, Beverly D AU - Hammons, George AD - National Center for Toxicological Research, Jefferson, AR, 72079, USA, ghammons@nctr.fda.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 265 EP - 272 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 24 IS - 3 SN - 0742-2091, 0742-2091 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Age KW - Methyltransferase KW - Genotyping KW - Aging KW - Cigarette smoking KW - Liver KW - DNA methylation KW - DNA methyltransferase KW - Enzymes KW - Tumors KW - Cancer KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20688943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infancy&rft.atitle=Test-Retest+Reliability+in+Infant+Speech+Perception+Tasks&rft.au=Cristia%2C+Alejandrina%3BSeidl%2C+Amanda%3BSingh%2C+Leher%3BHouston%2C+Derek&rft.aulast=Cristia&rft.aufirst=Alejandrina&rft.date=2016-09-01&rft.volume=21&rft.issue=5&rft.spage=648&rft.isbn=&rft.btitle=&rft.title=Infancy&rft.issn=15250008&rft_id=info:doi/10.1111%2Finfa.12127 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Methyltransferase; Genotyping; Cigarette smoking; Aging; DNA methylation; Liver; Enzymes; DNA methyltransferase; Tumors; Cancer DO - http://dx.doi.org/10.1007/s10565-007-9035-9 ER - TY - JOUR T1 - Modeling Neonatal Thimerosal Exposure in Mice AN - 20677092; 8204111 JF - Toxicological Sciences AU - Berman, Robert F AU - Pessah, Issac N AU - Mouton, Peter R AU - Mav, Deepak AU - Harry, GJean AD - Department of Neurological Surgery and the Center for Children's Environmental Health, University of California Davis, California 95616. Center for Children's Environmental Health and Department of Molecular Biosciences, University of California Davis, California 95616. Stereology Resource Center, 104 Ringneck Court, Chester, Maryland 21619. Constella Group, LLC, Durham, North Carolina 27713. Neurotoxicology Group, Laboratory of Neurobiology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 416 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 2 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - thimerosal KW - Neonates KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20677092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Modeling+Neonatal+Thimerosal+Exposure+in+Mice&rft.au=Berman%2C+Robert+F%3BPessah%2C+Issac+N%3BMouton%2C+Peter+R%3BMav%2C+Deepak%3BHarry%2C+GJean&rft.aulast=Berman&rft.aufirst=Robert&rft.date=2008-06-01&rft.volume=103&rft.issue=2&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - thimerosal; Neonates ER - TY - JOUR T1 - Occupational physical activities and long-term functional and radiographic outcomes in patients with ankylosing spondylitis AN - 20624661; 9350050 AB - Objective We sought to identify specific occupational activities associated with functional limitations and radiographic damage in patients with longstanding ankylosing spondylitis (AS). Methods We asked patients diagnosed with AS for 20 years to report all past occupations, which we mapped to specific physical activities using the Occupational Information Network, which is the US Department of Labor job classification database. For each occupation reported, we obtained ratings for 13 physical abilities of the worker and 13 aspects of the work environment or work tasks (work context) thought to be most relevant to patients with AS. Averages for each measure, weighted by the number of years in each job, were related to the degree of functional limitation as assessed by the Bath AS Functional Index (BASFI) and to the extent of spinal radiographic damage as assessed by the Bath AS Radiology Index for the spine (BASRI-s). Results Among 397 patients, those with a history of jobs requiring dynamic flexibility (the ability to repeatedly bend, stretch, twist, or reach) had more functional limitations than those whose past jobs required little or no dynamic flexibility (adjusted mean BASFI score 48.3 in the top quartile versus 38.1 in all others). Those whose past jobs required more dynamic flexibility, extent flexibility, and exposure to whole body vibration also had significantly higher BASRI-s scores. Conclusion Bending, twisting, and stretching are the occupational activities associated with greater functional limitations and radiographic damage in patients with longstanding AS. Exposure to whole body vibration was also associated with more radiographic damage. JF - Arthritis & Rheumatism AU - Ward, Michael M AU - Reveille, John D AU - Learch, Thomas J AU - Davis, John C AU - Weisman, Michael H AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, US Department of Health and Human Services, Bethesda, Maryland, wardm1@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 822 EP - 832 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 6 SN - 0004-3591, 0004-3591 KW - Toxicology Abstracts KW - Vibrations KW - Computer programs KW - Databases KW - Workers KW - Ankylosing spondylitis KW - Spine KW - Baths KW - Classification KW - Physical activity KW - Radiology KW - Occupational exposure KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20624661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Renal+cell+carcinoma%2C+occupational+pesticide+exposure+and+modification+by+glutathione+S-transferase+polymorphisms.&rft.au=Karami%2C+S%3BBoffetta%2C+P%3BRothman%2C+N%3BHung%2C+R+J%3BStewart%2C+T%3BZaridze%2C+D%3BNavritalova%2C+M%3BMates%2C+D%3BJanout%2C+V%3BKollarova%2C+H%3BBencko%2C+V%3BSzeszenia-Dabrowska%2C+N%3BHolcatova%2C+I%3BMukeria%2C+A%3BGromiec%2C+J%3BChanock%2C+S+J%3BBrennan%2C+P%3BChow%2C+W-H%3BMoore%2C+L+E&rft.aulast=Karami&rft.aufirst=S&rft.date=2008-08-01&rft.volume=29&rft.issue=8&rft.spage=1567&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn153 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Vibrations; Workers; Databases; Computer programs; Spine; Ankylosing spondylitis; Classification; Baths; Physical activity; Radiology; Occupational exposure DO - http://dx.doi.org/10.1002/art.23704 ER - TY - JOUR T1 - Aerosolization of Single-Walled Carbon Nanotubes for an Inhalation Study AN - 20235574; 10310424 AB - Single-walled carbon nanotubes (SWCNT) are being produced in increasing quantities because of high interest in applications resulting from their unique properties. Because of potential respiratory exposures during production and handling, inhalation studies are needed to determine potential toxicity. A generation system was designed to produce respirable aerosol at 5 mg/m3 for a 1-wk animal (mouse) exposure. The starting material used in these experiments was as-produced powder from the high pressure carbon monoxide method that was sieved to number 6 mesh (< 2.3 mm). An acoustic feeder system was developed that handled the SWCNT powder without causing compaction of the material. The feed rate was adjustable, allowing output concentrations as high as 25 mg/m3. The powder particles were reduced in size using a mill that produced high shear forces, tearing the agglomerates apart. The resulting aerosol was size-separated using a settling chamber and two cyclones to produce a respirable aerosol. The mass output efficiency of the entire system for producing a respirable aerosol from bulk material was estimated to be about 10%. JF - Inhalation Toxicology AU - Baron, Paul AU - Deye, Gregory AU - Chen, Bean AU - Schwegler-Berry, Diane AU - Shvedova, Anna AU - Castranova, Vincent AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 751 EP - 760 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 20 IS - 8 SN - 0895-8378, 0895-8378 KW - Toxicology Abstracts KW - Inhalation KW - Carbon monoxide KW - Cyclones KW - Powder KW - Aerosols KW - Acoustics KW - nanotubes KW - Toxicity KW - Pressure KW - Compaction KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20235574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+Toxicology&rft.atitle=Aerosolization+of+Single-Walled+Carbon+Nanotubes+for+an+Inhalation+Study&rft.au=Baron%2C+Paul%3BDeye%2C+Gregory%3BChen%2C+Bean%3BSchwegler-Berry%2C+Diane%3BShvedova%2C+Anna%3BCastranova%2C+Vincent&rft.aulast=Baron&rft.aufirst=Paul&rft.date=2008-06-01&rft.volume=20&rft.issue=8&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Inhalation+Toxicology&rft.issn=08958378&rft_id=info:doi/10.1080%2F08958370801975303 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cyclones; Carbon monoxide; Inhalation; Powder; Aerosols; Acoustics; nanotubes; Toxicity; Pressure; Compaction DO - http://dx.doi.org/10.1080/08958370801975303 ER - TY - JOUR T1 - Dopamine and reward: The anhedonia hypothesis 30 years on AN - 20143491; 10263374 AB - The anhedonia hypothesis -- that brain dopamine plays a critical role in the subjective pleasure associated with positive rewards -- was intended to draw the attention of psychiatrists to the growing evidence that dopamine plays a critical role in the objective reinforcement and incentive motivation associated with food and water, brain stimulation reward, and psychomotor stimulant and opiate reward. The hypothesis called to attention the apparent paradox that neuroleptics, drugs used to treat a condition involving anhedonia (schizophrenia), attenuated in laboratory animals the positive reinforcement that we normally associate with pleasure. The hypothesis held only brief interest for psychiatrists, who pointed out that the animal studies reflected acute actions of neuroleptics whereas the treatment of schizophrenia appears to result from neuroadaptations to chronic neuroleptic administration, and that it is the positive symptoms of schizophrenia that neuroleptics alleviate, rather than the negative symptoms that include anhedonia. Perhaps for these reasons, the hypothesis has had minimal impact in the psychiatric literature. Despite its limited heuristic value for the understanding of schizophrenia, however, the anhedonia hypothesis has had major impact on biological theories of reinforcement, motivation, and addiction. Brain dopamine plays a very important role in reinforcement of response habits, conditioned preferences, and synaptic plasticity in cellular models of learning and memory. The notion that dopamine plays a dominant role in reinforcement is fundamental to the psychomotor stimulant theory of addiction, to most neuroadaptation theories of addiction, and to current theories of conditioned reinforcement and reward prediction. Properly understood, it is also fundamental to recent theories of incentive motivation. JF - Neurotoxicity Research AU - Wise, Roy A AD - Department of Health and Human Services, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, USA, rwise@intra.nida.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 169 EP - 183 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 14 IS - 2-3 SN - 1029-8428, 1029-8428 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Opiates KW - Motivation KW - Food KW - Emotional behavior KW - Conditioned reinforcement KW - Brain KW - Laboratory animals KW - Plasticity (synaptic) KW - Psychomotor stimulants KW - Schizophrenia KW - Mental disorders KW - Memory KW - Dopamine KW - Neuroleptics KW - Neurotoxicity KW - Reinforcement KW - Problem solving KW - Addiction KW - Attention KW - Hedonic response KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20143491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+Research&rft.atitle=Dopamine+and+reward%3A+The+anhedonia+hypothesis+30+years+on&rft.au=Wise%2C+Roy+A&rft.aulast=Wise&rft.aufirst=Roy&rft.date=2008-06-01&rft.volume=14&rft.issue=2-3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+Research&rft.issn=10298428&rft_id=info:doi/10.1007%2FBF03033808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Opiates; Motivation; Food; Conditioned reinforcement; Emotional behavior; Laboratory animals; Brain; Plasticity (synaptic); Psychomotor stimulants; Schizophrenia; Memory; Mental disorders; Dopamine; Neuroleptics; Neurotoxicity; Reinforcement; Problem solving; Addiction; Hedonic response; Attention DO - http://dx.doi.org/10.1007/BF03033808 ER - TY - JOUR T1 - Postlicensure Monitoring of Intussusception After RotaTeq Vaccination in the United States, February 1, 2006, to September 25, 2007 AN - 19806125; 8304213 AB - BACKGROUND. In 1999, a previous rotavirus vaccine (RotaShield; Wyeth Laboratories, Marietta, PA) was withdrawn from the US market after postlicensure monitoring identified an association with intussusception. Although the new rotavirus vaccine (RotaTeq; Merck, West Point, PA) introduced in 2006 was not associated with intussusception in prelicensure trials, additional monitoring is important to ensure a complete safety profile. METHODS. We assessed intussusception reports after RotaTeq vaccination by using data from the Vaccine Adverse Event Reporting System and the Vaccine Safety Datalink, a cohort of children enrolled in managed care. Observed versus expected rate ratios were determined by using vaccine dose distribution data and Vaccine Safety Datalink background intussusception rates. RESULTS. Between February 1, 2006, and September 25, 2007, the Vaccine Adverse Event Reporting System received 160 intussusception reports after RotaTeq vaccination. With the assumptions that reporting completeness was 75% and that 75% of the distributed doses of RotaTeq were administered, the observed versus expected rate ratios were 0.53 and 0.91 for the 1-21 and 1-7 day interval after vaccination, respectively. In the Vaccine Safety Datalink, 3 intussusception cases occurred within 30 days after 111521 RotaTeq vaccinations, compared with 6 cases after 186722 non-RotaTeq vaccinations during the same period. If, like RotaShield, RotaTeq had a 37-fold increased risk of intussusception within 3 to 7 days after vaccination, then 8 intussusception cases would be expected within 3 to 7 days among the 684000 infants vaccinated with the first dose of RotaTeq in the Vaccine Safety Datalink (N = 49902) and the prelicensure trial (N = 34035) combined, whereas no cases have been observed. CONCLUSIONS. Available data do not indicate that RotaTeq is associated with intussusception. Although an intussusception risk similar in magnitude to that of RotaShield can be excluded, continued monitoring is necessary for complete assessment of the safety profile of RotaTeq. JF - Pediatrics AU - Haber, Penina AU - Patel, Manish AU - Izurieta, Hector S AU - Baggs, James AU - Gargiullo, Paul AU - Weintraub, Eric AU - Cortese, Margaret AU - Braun, MMiles AU - Belongia, Edward A AU - Miller, Elaine AU - Ball, Robert AU - Iskander, John AU - Parashar, Umesh D AD - Immunization Safety Office, Office of the Chief Science Officer. National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland. Marshfield Clinic Research Foundation, Epidemiology Research Center, Marshfield, Wisconsin Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1206 EP - 1212 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - 6 SN - 0031-4005, 0031-4005 KW - Risk Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Rotavirus KW - vaccines KW - Data processing KW - Children KW - Vaccination KW - USA KW - Combined vaccines KW - intussusception KW - Vaccines KW - Side effects KW - Infants KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19806125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Postlicensure+Monitoring+of+Intussusception+After+RotaTeq+Vaccination+in+the+United+States%2C+February+1%2C+2006%2C+to+September+25%2C+2007&rft.au=Haber%2C+Penina%3BPatel%2C+Manish%3BIzurieta%2C+Hector+S%3BBaggs%2C+James%3BGargiullo%2C+Paul%3BWeintraub%2C+Eric%3BCortese%2C+Margaret%3BBraun%2C+MMiles%3BBelongia%2C+Edward+A%3BMiller%2C+Elaine%3BBall%2C+Robert%3BIskander%2C+John%3BParashar%2C+Umesh+D&rft.aulast=Haber&rft.aufirst=Penina&rft.date=2008-06-01&rft.volume=121&rft.issue=6&rft.spage=1206&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Combined vaccines; intussusception; Vaccines; Children; Vaccination; Infants; vaccines; Side effects; Rotavirus; USA ER - TY - JOUR T1 - Synthesis and potency of novel uracil nucleotides and derivatives as P2Y sub(2) and P2Y sub(6) receptor agonists AN - 19725287; 8808036 AB - The phosphate, uracil, and ribose moieties of uracil nucleotides were varied structurally for evaluation of agonist activity at the human P2Y sub(2), P2Y sub(4), and P2Y sub(6) receptors. The 2-thio modification, found previously to enhance P2Y sub(2) receptor potency, could be combined with other favorable modifications to produce novel molecules that exhibit high potencies and receptor selectivities. Phosphonomethylene bridges introduced for stability in analogues of UDP, UTP, and uracil dinucleotides markedly reduced potency. Truncation of dinucleotide agonists of the P2Y sub(2) receptor, in the form of Up sub(4)-sugars, indicated that a terminal uracil ring is not essential for moderate potency at this receptor and that specific SAR patterns are observed at this distal end of the molecule. Key compounds reported in this study include 9, alpha , beta -methylene-UDP, a P2Y sub(6) receptor agonist; 30, Up sub(4)- phenyl ester and 34, Up sub(4)-[1]glucose, selective P2Y sub(2) receptor agonists; dihalomethylene phosphonate analogues 16 and 41, selective P2Y sub(2) receptor agonists; 43, the 2-thio analogue of INS37217 (P super(1)- (uridine-5')-P super(4)-(2'-deoxycytidine-5')tetraphosphate), a potent and selective P2Y sub(2) receptor agonist. JF - Bioorganic and Medicinal Chemistry AU - Ko, Hyojin AU - Carter, Rhonda L AU - Cosyn, Liesbet AU - Petrelli, Riccardo AU - De Castro, Sonia AU - Besada, Pedro AU - Zhou, Yixing AU - Cappellacci, Loredana AU - Franchetti, Palmarisa AU - Grifantini, Mario AU - Van Calenbergh, Serge AU - Harden, TKendall AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-0810, USA, kajacobs@helix.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 6319 EP - 6332 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 12 SN - 0968-0896, 0968-0896 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - phosphonates KW - Phosphate KW - Uracil KW - Purine P2Y receptors KW - Ribose KW - Esters KW - Nucleotides KW - N 14840:Antisense, Nucleotide Analogs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19725287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis+and+potency+of+novel+uracil+nucleotides+and+derivatives+as+P2Y+sub%282%29+and+P2Y+sub%286%29+receptor+agonists&rft.au=Ko%2C+Hyojin%3BCarter%2C+Rhonda+L%3BCosyn%2C+Liesbet%3BPetrelli%2C+Riccardo%3BDe+Castro%2C+Sonia%3BBesada%2C+Pedro%3BZhou%2C+Yixing%3BCappellacci%2C+Loredana%3BFranchetti%2C+Palmarisa%3BGrifantini%2C+Mario%3BVan+Calenbergh%2C+Serge%3BHarden%2C+TKendall%3BJacobson%2C+Kenneth+A&rft.aulast=Ko&rft.aufirst=Hyojin&rft.date=2008-06-01&rft.volume=16&rft.issue=12&rft.spage=6319&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.05.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - phosphonates; Phosphate; Uracil; Ribose; Purine P2Y receptors; Esters; Nucleotides DO - http://dx.doi.org/10.1016/j.bmc.2008.05.013 ER - TY - JOUR T1 - Effectiveness of Local Exhaust Ventilation (LEV) in Controlling Engineered Nanomaterial Emissions During Reactor Cleanout Operations AN - 19581186; 8502066 AB - Abstract not available. JF - Journal of Occupational and Environmental Hygiene AU - Old, Leo AU - Methner, Mark M AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - D63 EP - D69 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 6 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Ventilation KW - Occupational exposure KW - nanotechnology KW - Exhaust emissions KW - Nanotechnology KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19581186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Effectiveness+of+Local+Exhaust+Ventilation+%28LEV%29+in+Controlling+Engineered+Nanomaterial+Emissions+During+Reactor+Cleanout+Operations&rft.au=Old%2C+Leo%3BMethner%2C+Mark+M&rft.aulast=Old&rft.aufirst=Leo&rft.date=2008-06-01&rft.volume=5&rft.issue=6&rft.spage=D63&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620802059393 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ventilation; Occupational exposure; Nanotechnology; Exhaust emissions; nanotechnology DO - http://dx.doi.org/10.1080/15459620802059393 ER - TY - JOUR T1 - A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine AN - 19580976; 8520611 AB - Prenatal exposure of the developing brain to cocaine causes morphological and behavioral abnormalities. Recent studies indicate that cocaine-induced proliferation inhibition and/or apoptosis in neural progenitor cells may play a pivotal role in causing these abnormalities. To understand the molecular mechanism through which cocaine inhibits cell proliferation in neural progenitors, we sought to identify the molecules that are responsible for mediating the effect of cocaine on cell cycle regulation. Methods and Findings Microarray analysis followed by quantitative real-time reverse transcription PCR was used to screen cocaine-responsive and cell cycle-related genes in a neural progenitor cell line where cocaine exposure caused a robust anti-proliferative effect by interfering with the G1-to-S transition. Cyclin A2, among genes related to the G1-to-S cell cycle transition, was most strongly down-regulated by cocaine. Down-regulation of cyclin A was also found in cocaine-treated human primary neural and A2B5+ progenitor cells, as well as in rat fetal brains exposed to cocaine in utero. Reversing cyclin A down-regulation by gene transfer counteracted the proliferation inhibition caused by cocaine. Further, we found that cocaine-induced accumulation of reactive oxygen species, which involves N-oxidation of cocaine via cytochrome P450, promotes cyclin A down-regulation by causing an endoplasmic reticulum (ER) stress response, as indicated by increased phosphorylation of eIF2a and expression of ATF4. In the developing rat brain, the P450 inhibitor cimetidine counteracted cocaine-induced inhibition of neural progenitor cell proliferation as well as down-regulation of cyclin A. Conclusions Our results demonstrate that down-regulation of cyclin A underlies cocaine-induced proliferation inhibition in neural progenitors. The down-regulation of cyclin A is initiated by N-oxidative metabolism of cocaine and consequent ER stress. Inhibition of cocaine N-oxidative metabolism by P450 inhibitors may provide a preventive strategy for counteracting the adverse effects of cocaine on fetal brain development. Investigating the mechanism of cocaine's effect on fetal brain development, Chun-Ting Lee and colleagues find that down-regulation of cyclin A by a cocaine metabolite inhibits neural proliferation. Editors' Summary Background. Every year, cocaine abuse by mothers during pregnancy exposes thousands of unborn infants (fetuses) to this powerful and addictive stimulant. Maternal cocaine abuse during early pregnancy increases the risk of miscarriage; its use during late pregnancy slows the baby's growth and can trigger premature labor. Babies exposed to cocaine shortly before birth are often irritable and have disturbed sleep patterns. They can also be very sensitive to sound and touch and consequently hard to comfort. These problems usually resolve spontaneously within the first few weeks of life but some permanent birth defects are also associated with frequent cocaine abuse during pregnancy. In particular, babies exposed to cocaine before birth sometimes have small heads-an abnormality that generally indicates a small brain-and, although they usually have normal intelligence, the development of their thinking skills and language is often delayed, and they can have behavioral problems. JF - PLOS Medicine AU - Lee, Chun-Ting AU - Chen, Jia AU - Hayashi, Teruo AU - Tsai, Shang-Yi AU - Sanchez, Joseph F AU - Errico, Stacie L AU - Amable, Rose AU - Su, Tsung-Ping AU - Lowe, Ross H AU - Huestis, Marilyn A AU - Shen, James AU - Becker, Kevin G AU - Geller, Herbert M AU - Freed, William J AU - Graeber, Manuel AD - Cellular Neurobiology Research Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Baltimore, Maryland, United States of America Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 5 IS - 6 SN - 1549-1277, 1549-1277 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Molecular modelling KW - Prenatal experience KW - Abortion KW - Cell cycle KW - Metabolites KW - Drug abuse KW - Reverse transcription KW - Expression vectors KW - Endoplasmic reticulum KW - Reactive oxygen species KW - Sound KW - Cocaine KW - Neural stem cells KW - Cimetidine KW - Cyclins KW - Brain KW - Stress KW - Toxicity KW - Fetuses KW - Pregnancy KW - Cyclin A KW - Cell division KW - Neurons KW - Tactile stimuli KW - Initiation factor eIF-2 KW - Cytochrome P450 KW - Cell proliferation KW - Side effects KW - Metabolism KW - Infants KW - X 24380:Social Poisons & Drug Abuse KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19580976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLOS+Medicine&rft.atitle=A+Mechanism+for+the+Inhibition+of+Neural+Progenitor+Cell+Proliferation+by+Cocaine&rft.au=Lee%2C+Chun-Ting%3BChen%2C+Jia%3BHayashi%2C+Teruo%3BTsai%2C+Shang-Yi%3BSanchez%2C+Joseph+F%3BErrico%2C+Stacie+L%3BAmable%2C+Rose%3BSu%2C+Tsung-Ping%3BLowe%2C+Ross+H%3BHuestis%2C+Marilyn+A%3BShen%2C+James%3BBecker%2C+Kevin+G%3BGeller%2C+Herbert+M%3BFreed%2C+William+J%3BGraeber%2C+Manuel&rft.aulast=Lee&rft.aufirst=Chun-Ting&rft.date=2008-06-01&rft.volume=5&rft.issue=6&rft.spage=e117&rft.isbn=&rft.btitle=&rft.title=PLOS+Medicine&rft.issn=15491277&rft_id=info:doi/10.1371%2Fjournal.pmed.0050117 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Prenatal experience; Abortion; Cell cycle; Metabolites; Drug abuse; Reverse transcription; Expression vectors; Endoplasmic reticulum; Reactive oxygen species; Sound; Cocaine; Cimetidine; Neural stem cells; Cyclins; Brain; Stress; Toxicity; Fetuses; Pregnancy; Cyclin A; Cell division; Neurons; Tactile stimuli; Cytochrome P450; Initiation factor eIF-2; Cell proliferation; Metabolism; Side effects; Infants DO - http://dx.doi.org/10.1371/journal.pmed.0050117 ER - TY - JOUR T1 - Mental Health Outcomes in Police Personnel After Hurricane Katrina AN - 19531794; 8352329 AB - Objective: We examined symptoms of depression and posttraumatic stress disorder (PTSD) among New Orleans Police Department (NOPD) personnel who provided law enforcement and relief services to affected communities following Hurricane Katrina. Methods: We conducted a cross-sectional survey of mental health outcomes related to personal and work-related exposures of police personnel 8 weeks after the Hurricane. Results: Of the 912 police personnel who completed the questionnaire, 227 (26%) reported symptoms consistent with depression and 170 (19%) reported symptoms consistent with PTSD. Risk factors associated with PTSD include recovery of bodies, crowd control, assault, and injury to a family member. Depressive symptoms were associated with rare family contact, uninhabitable home, isolation from the NOPD, assault, and injury to a family member. Conclusions: Police personnel reported symptoms of PTSD and depression associated with work-related and personal factors following Hurricane Katrina. JF - Journal of Occupational and Environmental Medicine AU - West, C AU - Bernard, B AU - Mueller, C AU - Kitt, M AU - Driscoll, R AU - Tak, S AD - CDC/NIOSH/DSHEFS, 4676 Columbia Parkway R-10, Cincinnati, OH 45226, USA, cawest@cdc.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 689 EP - 695 VL - 50 IS - 6 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - Psychology KW - police KW - law enforcement KW - posttraumatic stress disorder KW - Disasters KW - depression KW - USA, Louisiana, New Orleans KW - Hurricanes KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19531794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Mental+Health+Outcomes+in+Police+Personnel+After+Hurricane+Katrina&rft.au=West%2C+C%3BBernard%2C+B%3BMueller%2C+C%3BKitt%2C+M%3BDriscoll%2C+R%3BTak%2C+S&rft.aulast=West&rft.aufirst=C&rft.date=2008-06-01&rft.volume=50&rft.issue=6&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181638685 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Louisiana, New Orleans; police; Occupational health; Disasters; Hurricanes; posttraumatic stress disorder; depression; Injuries; Psychology; law enforcement DO - http://dx.doi.org/10.1097/JOM.0b013e3181638685 ER - TY - JOUR T1 - Assessment of Stromal-Derived Inducing Activity in the Generation of Dopaminergic Neurons from Human Embryonic Stem Cells AN - 19477851; 8305126 AB - Producing dopaminergic (DA) neurons is a major goal of human embryonic stem cell (hESC) research. DA neurons can be differentiated from hESC by coculture with the mouse PA6 stromal cell line; this differentiation-inducing effect is termed stromal-derived inducing activity (SDIA). The molecular and biochemical nature of SDIA is, however, unknown. Various studies have suggested that SDIA involves either a fixation-resistant component located on the PA6 cell surface or factors secreted into the medium by PA6 cells. To address this question, hESC were cocultured with PA6 cells for 12 days and then further differentiated with sonic hedgehog homolog, fibroblast growth factor-8, and glial cell line-derived neurotrophic factor. After 18 days, 34% of cells were tyrosine hydroxylase (TH)+. When PA6 cells were fixed or irradiated, the number of TH+ cells was decreased by threefold, whereas mitomycin-c treatment of feeder cells decreased the number of TH+ cells by 32%. The neural-inducing effect of PA6 cells, as monitored by beta -III-tubulin expression, was minimally affected by mitomycin-c treatment or fixation but was decreased 50% by irradiation. Medium conditioned by PA6 cells was ineffective in differentiating TH+ cells when used alone. Conditioned medium combined with heparin and/or fixed PA6 cells produced TH+ cell differentiation, although less effectively than PA6 cell coculture. Thus, PA6 cell surface activity is required for neural differentiation of hESC, but secreted factors are required for the specific DA neuron-inducing effect. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Vazin, Tandis AU - Chen, Jia AU - Lee, Chun-Ting AU - Amable, Rose AU - Freed, William J AD - Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1517 EP - 1525 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 26 IS - 6 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Cell surface KW - stromal cells KW - Glial cell line-derived neurotrophic factor KW - Cell culture KW - Mitomycin C KW - Differentiation KW - Neurogenesis KW - Stem cells KW - Hedgehog protein KW - Dopamine KW - Radiation KW - Embryo cells KW - Neurons KW - Tyrosine 3-monooxygenase KW - Heparin KW - N3 11001:Behavioral and Cognitive Neuroscience KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19477851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Assessment+of+Stromal-Derived+Inducing+Activity+in+the+Generation+of+Dopaminergic+Neurons+from+Human+Embryonic+Stem+Cells&rft.au=Vazin%2C+Tandis%3BChen%2C+Jia%3BLee%2C+Chun-Ting%3BAmable%2C+Rose%3BFreed%2C+William+J&rft.aulast=Vazin&rft.aufirst=Tandis&rft.date=2008-06-01&rft.volume=26&rft.issue=6&rft.spage=1517&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; stromal cells; Glial cell line-derived neurotrophic factor; Cell culture; Mitomycin C; Differentiation; Hedgehog protein; Stem cells; Neurogenesis; Dopamine; Embryo cells; Radiation; Neurons; Tyrosine 3-monooxygenase; Heparin ER - TY - JOUR T1 - General and plastic surgery devices; reclassification of the tissue adhesive for topical approximation of skin device. Final rule. AN - 69293718; 18605409 AB - The Food and Drug Administration (FDA) is reclassifying the device type, tissue adhesive for the topical approximation of skin, from class III (premarket approval) into class II (special controls). Tissue adhesives for non-topical uses remain in class III and continue to require premarket approval applications (PMAs). FDA is proposing this reclassification in accordance with the Federal Food, Drug, and Cosmetic Act (the act). Elsewhere in this issue of the Federal Register, FDA is announcing the availability of a guidance document entitled "Class II Special Controls Guidance Document: Tissue Adhesive for the Topical Approximation of Skin" that will serve as the special control for the reclassified device type. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2008/05/30/ PY - 2008 DA - 2008 May 30 SP - 31027 EP - 31033 VL - 73 IS - 105 SN - 0097-6326, 0097-6326 KW - Tissue Adhesives KW - 0 KW - Health technology assessment KW - United States KW - Equipment Safety -- classification KW - United States Food and Drug Administration KW - Reconstructive Surgical Procedures -- instrumentation KW - Reconstructive Surgical Procedures -- legislation & jurisprudence KW - Humans KW - Device Approval -- legislation & jurisprudence KW - Legislation, Drug KW - Administration, Topical KW - Tissue Adhesives -- adverse effects KW - Tissue Adhesives -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69293718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=General+and+plastic+surgery+devices%3B+reclassification+of+the+tissue+adhesive+for+topical+approximation+of+skin+device.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2008-05-30&rft.volume=73&rft.issue=105&rft.spage=31027&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-18 N1 - Date created - 2008-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methamphetamine causes microglial activation in the brains of human abusers. AN - 70785194; 18509037 AB - Methamphetamine is a popular addictive drug whose use is associated with multiple neuropsychiatric adverse events and toxic to the dopaminergic and serotonergic systems of the brain. Methamphetamine-induced neuropathology is associated with increased expression of microglial cells that are thought to participate in either pro-toxic or protective mechanisms in the brain. Although reactive microgliosis has been observed in animal models of methamphetamine neurotoxicity, no study has reported on the status of microglial activation in human methamphetamine abusers. The present study reports on 12 abstinent methamphetamine abusers and 12 age-, gender-, and education-matched control subjects who underwent positron emission tomography using a radiotracer for activated microglia, [(11)C](R)-(1-[2-chlorophenyl]-N-methyl-N-[1-methylpropyl]-3-isoquinoline carboxamide) ([(11)C](R)-PK11195). Compartment analysis was used to estimate quantitative levels of binding potentials of [(11)C](R)-PK11195 in brain regions with dopaminergic and/or serotonergic innervation. The mean levels of [(11)C](R)-PK11195 binding were higher in methamphetamine abusers than those in control subjects in all brain regions (>250% higher; p < 0.01 for all). In addition, the binding levels in the midbrain, striatum, thalamus, and orbitofrontal and insular cortices (p < 0.05) correlated inversely with the duration of methamphetamine abstinence. These results suggest that chronic self-administration of methamphetamine can cause reactive microgliosis in the brains of human methamphetamine abusers, a level of activation that appears to subside over longer periods of abstinence. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Sekine, Yoshimoto AU - Ouchi, Yasuomi AU - Sugihara, Genichi AU - Takei, Nori AU - Yoshikawa, Etsuji AU - Nakamura, Kazuhiko AU - Iwata, Yasuhide AU - Tsuchiya, Kenji J AU - Suda, Shiro AU - Suzuki, Katsuaki AU - Kawai, Masayoshi AU - Takebayashi, Kiyokazu AU - Yamamoto, Shigeyuki AU - Matsuzaki, Hideo AU - Ueki, Takatoshi AU - Mori, Norio AU - Gold, Mark S AU - Cadet, Jean L AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 SP - 5756 EP - 5761 VL - 28 IS - 22 KW - Antineoplastic Agents KW - 0 KW - Carbon Isotopes KW - Central Nervous System Stimulants KW - Isoquinolines KW - Methamphetamine KW - 44RAL3456C KW - PK 11195 KW - YNF83VN1RL KW - Index Medicus KW - Brain Mapping KW - Magnetic Resonance Imaging -- methods KW - Positron-Emission Tomography -- methods KW - Isoquinolines -- pharmacokinetics KW - Protein Binding -- drug effects KW - Humans KW - Antineoplastic Agents -- pharmacokinetics KW - Adult KW - Case-Control Studies KW - Carbon Isotopes -- pharmacokinetics KW - Male KW - Female KW - Methamphetamine -- adverse effects KW - Brain -- pathology KW - Microglia -- diagnostic imaging KW - Amphetamine-Related Disorders -- pathology KW - Amphetamine-Related Disorders -- diagnostic imaging KW - Central Nervous System Stimulants -- adverse effects KW - Amphetamine-Related Disorders -- etiology KW - Microglia -- drug effects KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70785194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Methamphetamine+causes+microglial+activation+in+the+brains+of+human+abusers.&rft.au=Sekine%2C+Yoshimoto%3BOuchi%2C+Yasuomi%3BSugihara%2C+Genichi%3BTakei%2C+Nori%3BYoshikawa%2C+Etsuji%3BNakamura%2C+Kazuhiko%3BIwata%2C+Yasuhide%3BTsuchiya%2C+Kenji+J%3BSuda%2C+Shiro%3BSuzuki%2C+Katsuaki%3BKawai%2C+Masayoshi%3BTakebayashi%2C+Kiyokazu%3BYamamoto%2C+Shigeyuki%3BMatsuzaki%2C+Hideo%3BUeki%2C+Takatoshi%3BMori%2C+Norio%3BGold%2C+Mark+S%3BCadet%2C+Jean+L&rft.aulast=Sekine&rft.aufirst=Yoshimoto&rft.date=2008-05-28&rft.volume=28&rft.issue=22&rft.spage=5756&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.1179-08.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-01 N1 - Date created - 2008-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurochem. 2004 Jun;89(6):1445-53 [15189347] Arch Gen Psychiatry. 2004 Jan;61(1):73-84 [14706946] Neurosci Lett. 2004 Sep 9;367(3):349-54 [15337264] J Pharmacol Exp Ther. 2004 Oct;311(1):1-7 [15163680] Brain Res. 1992 Aug 7;587(2):250-6 [1381982] J Pers Soc Psychol. 1992 Sep;63(3):452-9 [1403624] Radiology. 1993 Jan;186(1):59-65 [8416587] J Cereb Blood Flow Metab. 1996 Jan;16(1):42-52 [8530554] Trends Neurosci. 1996 Aug;19(8):312-8 [8843599] Nature. 1997 Apr 24;386(6627):827-30 [9126740] Mol Neurobiol. 1997 Dec;15(3):307-39 [9457704] J Immunol. 1998 Feb 15;160(4):1944-8 [9469457] Lancet. 1998 Oct 31;352(9138):1433-7 [9807990] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):868-73 [15644446] Ann Neurol. 2005 Feb;57(2):168-75 [15668962] J Neurochem. 2005 Feb;92(4):790-7 [15686480] Eur Neuropsychopharmacol. 2002 Dec;12(6):581-6 [12468021] Neuroimage. 2003 Jul;19(3):1085-94 [12880834] Am J Psychiatry. 2003 Sep;160(9):1699-701 [12944350] FASEB J. 2003 Oct;17(13):1775-88 [14519657] Neurosci Lett. 2003 Nov 27;352(1):13-6 [14615038] J Neurosci. 1999 Nov 15;19(22):10107-15 [10559418] J Psychoactive Drugs. 2000 Apr-Jun;32(2):137-41 [10908000] Biomed Chromatogr. 2000 Aug;14(5):293-300 [10960827] Brain. 2000 Nov;123 ( Pt 11):2321-37 [11050032] Mol Pharmacol. 2000 Dec;58(6):1247-56 [11093760] Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] Exp Neurol. 2001 Jun;169(2):219-30 [11358437] Am J Psychiatry. 2001 Aug;158(8):1206-14 [11481152] Lancet. 2001 Aug 11;358(9280):461-7 [11513911] Neuropsychopharmacology. 2002 Jan;26(1):53-63 [11751032] J Subst Abuse Treat. 2002 Sep;23(2):151-6 [12220613] Glia. 2002 Nov;40(2):206-17 [12379908] Mol Pharmacol. 2002 Nov;62(5):993-1000 [12391261] Exp Neurol. 2004 May;187(1):47-57 [15081587] Neuropsychopharmacology. 2004 May;29(5):1019-26 [15039764] Neuroimage. 2005 Jun;26(2):480-92 [15907305] Brain Res. 2005 Jul 19;1050(1-2):190-8 [15987631] Folia Neuropathol. 2005;43(2):81-9 [16012909] J Pharmacol Exp Ther. 2005 Nov;315(2):658-67 [16076935] Neurotox Res. 2005 Nov;8(3-4):199-206 [16371314] Arch Gen Psychiatry. 2006 Jan;63(1):90-100 [16389202] Eur J Pharmacol. 2006 Aug 21;544(1-3):1-9 [16859675] Biol Psychiatry. 2007 Mar 1;61(5):577-81 [16712806] CNS Neurol Disord Drug Targets. 2007 Jun;6(3):219-33 [17511618] J Neurosci. 2004 Jun 30;24(26):6028-36 [15229250] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.1179-08.2008 ER - TY - CPAPER T1 - Skeletal Muscle Morphology Following Chronic Stretch-Shortening Contraction Exposure: Effects of Glutathione Depletion and Age T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40929015; 4850950 JF - 55th Annual Meeting on American College of Sports Medicine AU - Baker, Brent A AU - Hollander, Melinda S AU - Kashon, Michael L AU - Cutlip, Robert G Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Skeletal muscle KW - Muscle contraction KW - Morphology KW - Age KW - Glutathione KW - Coenzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40929015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Skeletal+Muscle+Morphology+Following+Chronic+Stretch-Shortening+Contraction+Exposure%3A+Effects+of+Glutathione+Depletion+and+Age&rft.au=Baker%2C+Brent+A%3BHollander%2C+Melinda+S%3BKashon%2C+Michael+L%3BCutlip%2C+Robert+G&rft.aulast=Baker&rft.aufirst=Brent&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relation between OMNI-RPE and Heart Rate Wearing Running Clothes VS. Firefighter Ensembles during Treadmill Exercise T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40924644; 4851710 JF - 55th Annual Meeting on American College of Sports Medicine AU - Coca, Aitor AU - Sinkule, Edward J AU - Powell, Jeffrey B AU - Roberge, Raymond J AU - Williams, W Jon Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Firefighter services KW - Heart rate KW - Running KW - Physical training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40924644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Relation+between+OMNI-RPE+and+Heart+Rate+Wearing+Running+Clothes+VS.+Firefighter+Ensembles+during+Treadmill+Exercise&rft.au=Coca%2C+Aitor%3BSinkule%2C+Edward+J%3BPowell%2C+Jeffrey+B%3BRoberge%2C+Raymond+J%3BWilliams%2C+W+Jon&rft.aulast=Coca&rft.aufirst=Aitor&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Glutathione Depletion on Real-Time Muscle Performance during a Chronic Exposure of Stretch-Shortening Contractions: Age Effects T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40923212; 4851094 JF - 55th Annual Meeting on American College of Sports Medicine AU - Hollander, Melinda S AU - Baker, Brent A AU - Ensey, James AU - Kashon, Michael L AU - Cutlip, Robert G Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Muscle contraction KW - Age KW - Glutathione KW - Chronic exposure KW - Coenzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40923212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Effects+of+Glutathione+Depletion+on+Real-Time+Muscle+Performance+during+a+Chronic+Exposure+of+Stretch-Shortening+Contractions%3A+Age+Effects&rft.au=Hollander%2C+Melinda+S%3BBaker%2C+Brent+A%3BEnsey%2C+James%3BKashon%2C+Michael+L%3BCutlip%2C+Robert+G&rft.aulast=Hollander&rft.aufirst=Melinda&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Glutathione and Age on Muscle Performance during a Chronic Exposure of Stretch-Shortening Contractions T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40922699; 4850949 JF - 55th Annual Meeting on American College of Sports Medicine AU - Cutlip, Robert G AU - Baker, Brent A AU - Hollander, Melinda S AU - Ensey, James S AU - Kashon, Michael L Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Muscle contraction KW - Age KW - Glutathione KW - Chronic exposure KW - Coenzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40922699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Effects+of+Glutathione+and+Age+on+Muscle+Performance+during+a+Chronic+Exposure+of+Stretch-Shortening+Contractions&rft.au=Cutlip%2C+Robert+G%3BBaker%2C+Brent+A%3BHollander%2C+Melinda+S%3BEnsey%2C+James+S%3BKashon%2C+Michael+L&rft.aulast=Cutlip&rft.aufirst=Robert&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Response of Tibialis Anterior Tendon to a Chronic Exposure of Stretch-Shortening Cycles: Age Effects T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40922569; 4850686 JF - 55th Annual Meeting on American College of Sports Medicine AU - Ensey, James S AU - Hollander, Melinda S AU - Wu, John Z AU - Kashon, Michael L AU - Baker, Brent A AU - Cutlip, Robert G Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Age KW - Tendons KW - Chronic exposure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40922569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Response+of+Tibialis+Anterior+Tendon+to+a+Chronic+Exposure+of+Stretch-Shortening+Cycles%3A+Age+Effects&rft.au=Ensey%2C+James+S%3BHollander%2C+Melinda+S%3BWu%2C+John+Z%3BKashon%2C+Michael+L%3BBaker%2C+Brent+A%3BCutlip%2C+Robert+G&rft.aulast=Ensey&rft.aufirst=James&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Impact of the Climate Change on the Autumn Phytoplankton from the Gulf of Riga T2 - Third US-EU-Baltic International Symposium on Ocean Observations, Ecosystem-Based Management and Forecasting AN - 40911095; 4843375 JF - Third US-EU-Baltic International Symposium on Ocean Observations, Ecosystem-Based Management and Forecasting AU - Purvina, Santa AU - Purina, Ingrida AU - Barda, Ieva AU - Strode, Evita AU - Putna, Ieva AU - Yurkovska, Vija AU - Pfeifere, Mara AU - Balode, Maija Y1 - 2008/05/27/ PY - 2008 DA - 2008 May 27 KW - Baltic Sea, Riga Gulf KW - Phytoplankton KW - Climatic changes KW - Ecosystem disturbance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40911095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+US-EU-Baltic+International+Symposium+on+Ocean+Observations%2C+Ecosystem-Based+Management+and+Forecasting&rft.atitle=The+Impact+of+the+Climate+Change+on+the+Autumn+Phytoplankton+from+the+Gulf+of+Riga&rft.au=Purvina%2C+Santa%3BPurina%2C+Ingrida%3BBarda%2C+Ieva%3BStrode%2C+Evita%3BPutna%2C+Ieva%3BYurkovska%2C+Vija%3BPfeifere%2C+Mara%3BBalode%2C+Maija&rft.aulast=Purvina&rft.aufirst=Santa&rft.date=2008-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+US-EU-Baltic+International+Symposium+on+Ocean+Observations%2C+Ecosystem-Based+Management+and+Forecasting&rft.issn=&rft_id=info:doi/ L2 - http://www.us-eu-baltic2008.org/glance.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Modifications and insights into a method for the analysis of the nitrogen mustard mechlorethamine by high-performance liquid chromatography. AN - 69194647; 18471487 AB - Previously, a method was presented for the analysis of mechlorethamine by derivatization of this unstable nitrogen mustard to bis(2-phenylthioethyl)methylamine (PTEMA), a stable compound suitable for analysis by HPLC with UV detection [J.C. Reepmeyer, J. Chromatogr. A, 1085 (2005) 262]. Mechlorethamine HCl served as a reference standard and it was derivatized in situ simultaneously with samples of mechlorethamine HCl in ointment preparations. This paper presents the synthesis of PTEMA on a gram scale, synthesis of its picrate salt, bis(2-phenylthioethyl)methylamine picrate (PTEMAP), and isolation of the picrate as a crystalline solid. PTEMAP may serve as a reference standard replacing the toxic mechlorethamine HCl. Insights into the handling, storage, drying, and hygroscopic properties of mechlorethamine HCl and PTEMAP are discussed. In addition, one step following the derivatization procedure in the original method is recognized as a potential for error, and a procedure relating to the order of addition of reagents is presented to avoid this error. The method has been extended to the analysis of mechlorethamine in aqueous solutions. JF - Analytica chimica acta AU - Reepmeyer, John C AU - Ye, Wei AU - Ritschel, Wolfgang A AD - United States Food and Drug Administration, Center for Drug Evaluation and Research, Office of Phamaceutical Science, Division of Pharmaceutical Analysis, FDA, 1114 Market Street, Room 1002, St. Louis, MO 63101, USA. john.reepmeyer@fda.hhs.gov Y1 - 2008/05/26/ PY - 2008 DA - 2008 May 26 SP - 78 EP - 84 VL - 616 IS - 1 KW - Diethylamines KW - 0 KW - Solutions KW - Sulfides KW - bis(2-phenylthioethyl)methylamine KW - Water KW - 059QF0KO0R KW - Mechlorethamine KW - 50D9XSG0VR KW - Index Medicus KW - Sensitivity and Specificity KW - Molecular Structure KW - Chromatography, High Pressure Liquid -- standards KW - Water -- chemistry KW - Chromatography, High Pressure Liquid -- methods KW - Solutions -- chemistry KW - Sulfides -- chemical synthesis KW - Mechlorethamine -- standards KW - Mechlorethamine -- analysis KW - Diethylamines -- analysis KW - Sulfides -- analysis KW - Diethylamines -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69194647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+chimica+acta&rft.atitle=Modifications+and+insights+into+a+method+for+the+analysis+of+the+nitrogen+mustard+mechlorethamine+by+high-performance+liquid+chromatography.&rft.au=Reepmeyer%2C+John+C%3BYe%2C+Wei%3BRitschel%2C+Wolfgang+A&rft.aulast=Reepmeyer&rft.aufirst=John&rft.date=2008-05-26&rft.volume=616&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Analytica+chimica+acta&rft.issn=1873-4324&rft_id=info:doi/10.1016%2Fj.aca.2008.04.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-10 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.aca.2008.04.020 ER - TY - JOUR T1 - Analysis of tetramethylene disulfotetramine in foods using solid-phase microextraction-gas chromatography-mass spectrometry. AN - 69152553; 18378250 AB - An automated solid-phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) method for the determination of tetramethylene disulfotetramine in foods was developed. A comparison of direct immersion (DI) and headspace (HS) extraction techniques using a 70microm carbowax/divinylbenzene (CW/DVB) fiber is presented. The optimized DI-SPME method provided an aqueous extraction limit of detection (LOD) of 9.0ng/g while the HS-SPME LOD was 2.7ng/g. In both SPME modes, recovery was highly matrix dependent and quantification requires standard addition calibrations. Analysis of foods using DI-SPME encountered many obstacles including fiber fouling, low recovery and poor reproducibility. HS-SPME was successfully applied to food analysis with minimal interferences. Standard addition calibration curves for foods gave high linearity (R2>0.98), reproducibility (RSD<12%) and sensitivity with LODs ranging from 0.9 to 4.3ng/g. JF - Journal of chromatography. A AU - De Jager, Lowri S AU - Perfetti, Gracia A AU - Diachenko, Gregory W AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD, USA. lowri.dejager@fda.hhs.gov Y1 - 2008/05/23/ PY - 2008 DA - 2008 May 23 SP - 36 EP - 40 VL - 1192 IS - 1 SN - 0021-9673, 0021-9673 KW - Bridged-Ring Compounds KW - 0 KW - tetramethylenedisulfotetramine KW - F6TS3WME05 KW - Index Medicus KW - Food Analysis -- methods KW - Gas Chromatography-Mass Spectrometry -- methods KW - Food Contamination -- analysis KW - Solid Phase Microextraction -- methods KW - Bridged-Ring Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69152553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+A&rft.atitle=Analysis+of+tetramethylene+disulfotetramine+in+foods+using+solid-phase+microextraction-gas+chromatography-mass+spectrometry.&rft.au=De+Jager%2C+Lowri+S%3BPerfetti%2C+Gracia+A%3BDiachenko%2C+Gregory+W&rft.aulast=De+Jager&rft.aufirst=Lowri&rft.date=2008-05-23&rft.volume=1192&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2008.03.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-21 N1 - Date created - 2008-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.chroma.2008.03.042 ER - TY - CPAPER T1 - Can Disproportionality Analysis Play a Role in Monitoring Drug-Eluting Stent Safety? T2 - 16th World Congress of Cardiology (WCC 2008) AN - 41052018; 4905472 DE: JF - 16th World Congress of Cardiology (WCC 2008) AU - Duggirala, H AU - Yang, X AU - Van Manen, R. Y1 - 2008/05/18/ PY - 2008 DA - 2008 May 18 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41052018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+World+Congress+of+Cardiology+%28WCC+2008%29&rft.atitle=Can+Disproportionality+Analysis+Play+a+Role+in+Monitoring+Drug-Eluting+Stent+Safety%3F&rft.au=Duggirala%2C+H%3BYang%2C+X%3BVan+Manen%2C+R.&rft.aulast=Duggirala&rft.aufirst=H&rft.date=2008-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+World+Congress+of+Cardiology+%28WCC+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://circ.ahajournals.org/cgi/reprint/CIRCULATIONAHA.108.189875 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Incident Diabetes and Pesticide Exposure among Licensed Pesticide Applicators: Agricultural Health Study, 1993-2003 AN - 19583164; 8509145 AB - Exposure to certain environmental toxicants may be associated with increased risk of developing diabetes. The authors' aim was to investigate the relation between lifetime exposure to specific agricultural pesticides and diabetes incidence among pesticide applicators. The study included 33,457 licensed applicators, predominantly non-Hispanic White males, enrolled in the Agricultural Health Study. Incident diabetes was self-reported in a 5-year follow-up interview (1999-2003), giving 1,176 diabetics and 30,611 nondiabetics for analysis. Lifetime exposure to pesticides and covariate information were reported by participants at enrollment (1993-1997). Using logistic regression, the authors considered two primary measures of pesticide exposure: ever use and cumulative lifetime days of use. They found seven specific pesticides (aldrin, chlordane, heptachlor, dichlorvos, trichlorfon, alachlor, and cyanazine) for which the odds of diabetes incidence increased with both ever use and cumulative days of use. Applicators who had used the organochlorine insecticides aldrin, chlordane, and heptachlor more than 100 lifetime days had 51%, 63%, and 94% increased odds of diabetes, respectively. The observed association of organochlorine and organophosphate insecticides with diabetes is consistent with results from previous human and animal studies. Long-term exposure from handling certain pesticides, in particular, organochlorine and organophosphate insecticides, may be associated with increased risk of diabetes. JF - American Journal of Epidemiology AU - Montgomery, M P AU - Kamel, F AU - Saldana, T M AU - Alavanja, MCR AU - Sandler, D P AD - 1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, sandler@niehs.nih.gov Y1 - 2008/05/15/ PY - 2008 DA - 2008 May 15 SP - 1235 EP - 1246 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street VL - 167 IS - 10 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - agrochemicals KW - diabetes mellitus KW - environmental exposure KW - hydrocarbons, chlorinated KW - insecticides KW - pesticides KW - phosphoric acid esters KW - Organochlorine compounds KW - Toxicants KW - Organophosphates KW - Aldrin KW - Insecticides KW - Occupational exposure KW - Dichlorvos KW - Pesticides (organophosphorus) KW - heptachlor KW - Chlordane KW - dichlorvos KW - Alachlor KW - Herbicides KW - organophosphates KW - Diabetes mellitus KW - Heptachlor KW - Pesticides KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19583164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Incident+Diabetes+and+Pesticide+Exposure+among+Licensed+Pesticide+Applicators%3A+Agricultural+Health+Study%2C+1993-2003&rft.au=Montgomery%2C+M+P%3BKamel%2C+F%3BSaldana%2C+T+M%3BAlavanja%2C+MCR%3BSandler%2C+D+P&rft.aulast=Montgomery&rft.aufirst=M&rft.date=2008-05-15&rft.volume=167&rft.issue=10&rft.spage=1235&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwn028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Pesticides (organophosphorus); Organochlorine compounds; Insecticides; Toxicants; Chlordane; heptachlor; Aldrin; Pesticides; Alachlor; organophosphates; Dichlorvos; Organophosphates; dichlorvos; Herbicides; diabetes mellitus; Heptachlor; Occupational exposure DO - http://dx.doi.org/10.1093/aje/kwn028 ER - TY - CPAPER T1 - DNp63a Modulates Keratinocyte Growth Regulation via Activation of NF-kB/c-Rel T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40954560; 4867808 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - King, K E AU - Ponnamperuma, R M AU - Allen, C AU - Chen, Z AU - Van Waes, C. AU - Weinberg, W C Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - NF-B protein KW - Keratinocytes KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40954560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=DNp63a+Modulates+Keratinocyte+Growth+Regulation+via+Activation+of+NF-kB%2Fc-Rel&rft.au=King%2C+K+E%3BPonnamperuma%2C+R+M%3BAllen%2C+C%3BChen%2C+Z%3BVan+Waes%2C+C.%3BWeinberg%2C+W+C&rft.aulast=King&rft.aufirst=K&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Automated Evaluation of HER-2/NEU Immunohistochemical Expression in Breast Cancer Using Digital Microscopy T2 - Fifth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008) AN - 40907965; 4846900 JF - Fifth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008) AU - Gavrielides, Marios AU - Masmoudi, Hela AU - Petrick, Nicholas AU - Myers, Kyle AU - Hewitt, Stephen Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Breast cancer KW - Microscopy KW - ErbB-2 protein KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40907965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifth+IEEE+International+Symposium+on+Biomedical+Imaging%3A+From+Nano+to+Macro+%28ISBI+2008%29&rft.atitle=Automated+Evaluation+of+HER-2%2FNEU+Immunohistochemical+Expression+in+Breast+Cancer+Using+Digital+Microscopy&rft.au=Gavrielides%2C+Marios%3BMasmoudi%2C+Hela%3BPetrick%2C+Nicholas%3BMyers%2C+Kyle%3BHewitt%2C+Stephen&rft.aulast=Gavrielides&rft.aufirst=Marios&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifth+IEEE+International+Symposium+on+Biomedical+Imaging%3A+From+Nano+to+Macro+%28ISBI+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biomedicalimaging.org/RegularProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapeutic Equivalence of Inhaled Corticosteroids - US Perspectives T2 - 2008 Conference on Respiratory Drug Delivery (RDD 2008) AN - 40909416; 4845482 JF - 2008 Conference on Respiratory Drug Delivery (RDD 2008) AU - Chowdhury, Badrul A Y1 - 2008/05/11/ PY - 2008 DA - 2008 May 11 KW - Corticoids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40909416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Conference+on+Respiratory+Drug+Delivery+%28RDD+2008%29&rft.atitle=Therapeutic+Equivalence+of+Inhaled+Corticosteroids+-+US+Perspectives&rft.au=Chowdhury%2C+Badrul+A&rft.aulast=Chowdhury&rft.aufirst=Badrul&rft.date=2008-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Conference+on+Respiratory+Drug+Delivery+%28RDD+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.rddonline.com/rdd/rdd.php?id=3&sid=3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vibration Exposure Induces Mechanical Hyperalgesia in Lean but Not Fatty Zucker Rats T2 - 27th Annual Scientific Meeting of the American Pain Society (APS 2008) AN - 40916040; 4850364 JF - 27th Annual Scientific Meeting of the American Pain Society (APS 2008) AU - Krajnak, K AU - Johnson, C AU - Waugh, S AU - Miller, R Y1 - 2008/05/07/ PY - 2008 DA - 2008 May 07 KW - Vibration KW - Rats KW - Pain perception KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40916040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Scientific+Meeting+of+the+American+Pain+Society+%28APS+2008%29&rft.atitle=Vibration+Exposure+Induces+Mechanical+Hyperalgesia+in+Lean+but+Not+Fatty+Zucker+Rats&rft.au=Krajnak%2C+K%3BJohnson%2C+C%3BWaugh%2C+S%3BMiller%2C+R&rft.aulast=Krajnak&rft.aufirst=K&rft.date=2008-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Scientific+Meeting+of+the+American+Pain+Society+%28APS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ampainsoc.org/meeting/annual_08/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Persistent Organochlorine Pesticides and Risk of Testicular Germ Cell Tumors AN - 20710753; 8201280 AB - BACKGROUND: Exposure to endocrine-disrupting chemicals, such as persistent organochlorine pesticides, has been suggested to increase the risk of testicular germ cell tumors (TGCTs). METHODS: To study the relationship of POP exposure to TGCT risk, prediagnostic serum samples from 754 case subjects and 928 control subjects enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study were analyzed for cis-nonachlor, trans-nonachlor, oxychlordane, total chlordanes, beta -hexachlorocyclohexane, mirex, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and p,p'-dichlorodiphenyltrichloroethane. Adjusted odds ratios (ORs) and their associated 95% confidence intervals (CIs) for the risk of TGCT overall and for the histological subgroups, seminoma and nonseminoma, were estimated using multivariable logistic regression. All statistical tests were two-sided. RESULTS: TGCT risk was statistically significantly associated with higher plasma levels of p,p'-DDE (for highest quartile [Q4] vs lowest quartile [Q1], OR = 1.71, 95% CI = 1.23 to 2.38, P sub(trend) = .0002) and of two chlordane components, cis-nonachlor (Q4 vs Q1, OR = 1.56, 95% CI = 1.11 to 2.18, P sub(trend) = .009) and trans-nonachlor (Q4 vs Q1, OR = 1.46, 95% CI = 1.07 to 2.00, P sub(trend) = .026). Seminoma risk was statistically significantly associated with p,p'-DDE (Q4 vs Q1, OR = 1.91, 95% CI = 1.22 to 2.99, P sub(trend) = .0008), cis-nonachlor (Q4 vs Q1, OR = 1.93, 95% CI = 1.27 to 2.93, P sub(trend) = .0045), trans-nonachlor (Q4 vs Q1, OR = 1.72, 95% CI = 1.11 to 2.67, P sub(trend) = .033), and a chlordane metabolite, oxychlordane (Q4 vs Q1, OR = 1.64, 95% CI = 1.04 to 2.60, P sub(trend) = .048), whereas nonseminoma risk showed a statistically significant association with p,p'-DDE only (Q4 vs Q1, OR = 1.63, 95% CI = 1.10 to 2.42, P sub(trend) = .0044). CONCLUSIONS: Increased exposure to p,p'-DDE may be associated with the risk of both seminomatous and nonseminomatous TGCTs, whereas exposure to chlordane compounds and metabolites may be associated with the risk of seminoma. Because evidence suggests that TGCT is initiated in very early life, it is possible that exposure to these persistent organic pesticides during fetal life or via breast feeding may increase the risk of TGCT in young men. JF - Journal of the National Cancer Institute AU - McGlynn, Katherine A AU - Quraishi, Sabah M AU - Graubard, Barry I AU - Weber, Jean-Philippe AU - Rubertone, Mark V AU - Erickson, Ralph L AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (KAM, SMQ, BIG) Y1 - 2008/05/07/ PY - 2008 DA - 2008 May 07 SP - 663 EP - 671 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 100 IS - 9 SN - 0027-8874, 0027-8874 KW - Health & Safety Science Abstracts; Risk Abstracts KW - breast feeding KW - Chemicals KW - Organochlorine compounds KW - endocrine disruptors KW - Metabolites KW - tumors KW - Insecticides KW - Chlordane KW - Cancer KW - Pesticides KW - Mirex KW - H 5000:Pesticides KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20710753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Persistent+Organochlorine+Pesticides+and+Risk+of+Testicular+Germ+Cell+Tumors&rft.au=McGlynn%2C+Katherine+A%3BQuraishi%2C+Sabah+M%3BGraubard%2C+Barry+I%3BWeber%2C+Jean-Philippe%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2008-05-07&rft.volume=100&rft.issue=9&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chlordane; Insecticides; tumors; Pesticides; Metabolites; Cancer; Organochlorine compounds; endocrine disruptors; Chemicals; breast feeding; Mirex ER - TY - JOUR T1 - Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats. AN - 69159233; 18407439 AB - Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-alpha activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity. JF - Toxicology letters AU - Cho, Wan-Seob AU - Han, Beom Seok AU - Ahn, Byeongwoo AU - Nam, Ki Taek AU - Choi, Mina AU - Oh, Sang Yeon AU - Kim, Seung Hee AU - Jeong, Jayoung AU - Jang, Dong Deuk AD - National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea. Y1 - 2008/05/05/ PY - 2008 DA - 2008 May 05 SP - 110 EP - 116 VL - 178 IS - 2 SN - 0378-4274, 0378-4274 KW - Carcinogens KW - 0 KW - Peroxisome Proliferators KW - Phthalic Acids KW - Catalase KW - EC 1.11.1.6 KW - diisodecyl phthalate KW - WF93T741QI KW - Index Medicus KW - Eating -- drug effects KW - Animals KW - Sex Characteristics KW - Neoplasms -- epidemiology KW - Rats KW - Catalase -- metabolism KW - Rats, Inbred F344 KW - Blotting, Western KW - Body Weight -- drug effects KW - Neoplasms -- chemically induced KW - Carcinogenicity Tests KW - Immunohistochemistry KW - Female KW - Male KW - Survival Analysis KW - Organ Size -- drug effects KW - Peroxisome Proliferators -- toxicity KW - Phthalic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69159233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Peroxisome+proliferator+di-isodecyl+phthalate+has+no+carcinogenic+potential+in+Fischer+344+rats.&rft.au=Cho%2C+Wan-Seob%3BHan%2C+Beom+Seok%3BAhn%2C+Byeongwoo%3BNam%2C+Ki+Taek%3BChoi%2C+Mina%3BOh%2C+Sang+Yeon%3BKim%2C+Seung+Hee%3BJeong%2C+Jayoung%3BJang%2C+Dong+Deuk&rft.aulast=Cho&rft.aufirst=Wan-Seob&rft.date=2008-05-05&rft.volume=178&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2008.02.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-09 N1 - Date created - 2008-04-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Toxicol Lett. 2010 Aug 16;197(2):156 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2008.02.013 ER - TY - JOUR T1 - Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine. AN - 69158324; 18395999 AB - Pyrrolizidine alkaloid-containing plants are widespread in the world and may be the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids require metabolism to exert their genotoxicity and tumorigenicity. Our mechanistic studies have determined that metabolism of the retronecine-type (riddelliine, retrorsine, and monocrotaline), heliotridine-type (lasiocarpine), and otonecine-type (clivorine) tumorigenic pyrrolizidine alkaloids in vivo and/or in vitro all generates a common set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts responsible for tumor induction. All the pyrrolizidine alkaloids studied previously are diesters with an ester linkage at the C7 and C9 positions of the necine base. In this study, we report that F344 rat liver microsomal metabolism of heliotrine, a tumorigenic monoester bearing a hydroxyl group at the C7 of the necine base, resulted in the formation of the dehydroheliotridine (DHH) metabolite. When incubations of heliotrine were carried out in the presence of calf thymus DNA, the same set of DHP-derived DNA adducts was formed. These results support that DHP-derived DNA adducts are potential common biomarkers of pyrrolizidine alkaloid exposure and tumorigenicity. For comparison, the dehydroretronecine (DHR)-derived DNA adducts formed from metabolism of riddleiine, retrorsine, monocrotaline, riddelleiine N-oxide, and retrorsine N-oxide were measured in parallel; the levels of DHP-derived DNA adduct formation were in the order: riddelliine approximately retrorsine>monocrotaline>retrorsine N-oxide>or=riddelliine N-oxide>heliotrine. JF - Toxicology letters AU - Xia, Qingsu AU - Yan, Jian AU - Chou, Ming W AU - Fu, Peter P AD - National Center for Toxicological Research, Jefferson, AR 72079, United States. Y1 - 2008/05/05/ PY - 2008 DA - 2008 May 05 SP - 77 EP - 82 VL - 178 IS - 2 SN - 0378-4274, 0378-4274 KW - Biomarkers KW - 0 KW - DNA Adducts KW - Pyrrolizidine Alkaloids KW - riddelliine KW - 23246-96-0 KW - heliotrine KW - 303-33-3 KW - Monocrotaline KW - 73077K8HYV KW - DNA KW - 9007-49-2 KW - dehydroretronecine KW - QG6MWR17OH KW - retrorsine KW - XJ86XWL8IY KW - Index Medicus KW - Animals KW - Stereoisomerism KW - DNA -- pharmacology KW - Microsomes, Liver -- metabolism KW - Thymus Gland -- chemistry KW - Circular Dichroism KW - Biotransformation -- drug effects KW - Chromatography, High Pressure Liquid KW - Isotope Labeling KW - Rats KW - Rats, Inbred F344 KW - Cattle KW - In Vitro Techniques KW - Male KW - Monocrotaline -- metabolism KW - Monocrotaline -- analogs & derivatives KW - Pyrrolizidine Alkaloids -- metabolism KW - DNA Adducts -- drug effects KW - Monocrotaline -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69158324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Formation+of+DHP-derived+DNA+adducts+from+metabolic+activation+of+the+prototype+heliotridine-type+pyrrolizidine+alkaloid%2C+heliotrine.&rft.au=Xia%2C+Qingsu%3BYan%2C+Jian%3BChou%2C+Ming+W%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2008-05-05&rft.volume=178&rft.issue=2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2008.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-09 N1 - Date created - 2008-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2008.02.008 ER - TY - JOUR T1 - Elective termination of pregnancy after vaccination reported to the Vaccine Adverse Event Reporting System (VAERS): 1990-2006. AN - 69150273; 18406499 AB - Generally, live-virus vaccines are contraindicated for pregnant women because of the theoretical risk of transmission of the vaccine virus to the fetus. Advisory groups recommend avoiding pregnancy in the immediate period after administration of such contraindicated vaccines (CVs) and stress benefit-to-risk evaluation for live or inactivated vaccines regarding pregnancy. Given the limited available data and theoretical risks associated particularly with live-virus vaccines, inadvertent immunization with CVs may lead to elective termination of pregnancy (ETP), despite advisory group statements that "vaccination is not ordinarily an indication to terminate the pregnancy." The Vaccine Adverse Event Reporting System (VAERS), a national passive surveillance system managed by the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC), accepts reports of adverse events after vaccination. The objectives of this review were to describe reports of ETP in VAERS and characterize the circumstances of inadvertent administration of vaccines to pregnant women among ETP reports. We reviewed VAERS reports of ETP submitted from 1990 to 2006. Reports of ETP for reasons other than vaccination during or shortly before pregnancy, such as fetal abnormalities or deaths, were excluded. Of 80 ETP reports, 62 (78%) originated from the US; 79 (99%) were reported by manufacturers. Median age of vaccinees was 26 years (range: 13-43 years; 67 reports). Seventy-three vaccinees (91%) received a single vaccine; 65 (81%) received at least one live-virus vaccine. In 48 (60%) ETP reports, vaccinees were unaware of pregnancy at time of immunization. In 15 (19%) reports, vaccinees became pregnant within 3 months of vaccination; in 13 (16%) reports, vaccinees might have been pregnant before vaccination; in 4 (5%) reports, information was missing. All 80 reports of ETP involved vaccines for which possible effects on fetal development are unknown. However, no cases of vaccine-associated congenital rubella or varicella syndromes have been reported in the medical literature. Also, these syndromes have not been reported to varicella or rubella vaccine pregnancy registries. VAERS has the limitations of passive surveillance systems. Under-reporting of ETP in VAERS could be substantial. More attention may be needed to assess the likelihood of pregnancy when administering vaccines to women with child-bearing potential, and to inform women who learn they are pregnant shortly after being immunized of current information on risks. Quantifying the frequency of ETP related to CVs and the risk (if any) to the fetus of such vaccines can help to inform policy, practice, and individual decision making. Good quality information may be obtained from controlled observational studies. JF - Vaccine AU - Chang, Soju AU - Ball, Robert AU - Braun, M Miles AD - Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, HFM-222, Rockville, MD 20852 United States. soju.chang@fda.hhs.gov Y1 - 2008/05/02/ PY - 2008 DA - 2008 May 02 SP - 2428 EP - 2432 VL - 26 IS - 19 SN - 0264-410X, 0264-410X KW - Viral Vaccines KW - 0 KW - Index Medicus KW - United States KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Adult KW - Adolescent KW - Female KW - Pregnancy KW - Viral Vaccines -- adverse effects KW - Abortion, Eugenic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69150273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Elective+termination+of+pregnancy+after+vaccination+reported+to+the+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29%3A+1990-2006.&rft.au=Chang%2C+Soju%3BBall%2C+Robert%3BBraun%2C+M+Miles&rft.aulast=Chang&rft.aufirst=Soju&rft.date=2008-05-02&rft.volume=26&rft.issue=19&rft.spage=2428&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.02.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-24 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.vaccine.2008.02.052 ER - TY - GEN T1 - Tribal Child Care and Development Fund: Guide for New Administrators AN - 881462028; ED519375 AB - Tribal Child Care and Development Fund administrators work each day to ensure that the children and families in tribal communities have the child care services that best meet their needs. The Child Care and Development Fund (CCDF), a federal block grant for States, Tribes, and Territories, is a key resource to help increase the availability, affordability, and quality of child care services. With Child Care and Development Funds, tribal CCDF administrators can support low-income families, families receiving temporary public assistance, and those transitioning from public assistance in obtaining child care services so they may work, attend training, or participate in educational activities. Developed from information and resources provided at national and regional tribal CCDF administrator trainings, this Guide brings together the technical and practical aspects of tribal CCDF administration. Examples of effective program strategies are provided to illustrate the various ways that tribal CCDF administrators respond to the needs of children and families served through the child care assistance program. Footnotes in each section point to sources of additional information, including guidance documents disseminated by the Child Care Bureau and specific sections of the Federal regulations that govern the CCDF program. Tribal CCDF administrators should always consult the regulations and current CCDF guidance for the most comprehensive and up-to-date information on the management of a tribal CCDF program. Appendices include: (1) Getting Started as a New Administrator; (2) Federal CCDF Contacts and Resources; (3) Sample Quality Activities; (4) Potential Collaborative Partners for Tribal CCDF Programs; and (5) Tribal CCDF Dates to Remember. (Contains 46 footnotes.) Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 34 PB - Child Care Bureau. US Department of Health and Human Services, Administration for Children & Families, Office of Family Assistance, 370 L'Enfant Promenade SW 5th Floor East, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Administrators KW - Elementary Secondary Education KW - Low Income Groups KW - Program Administration KW - Federal Aid KW - Family Needs KW - Administrator Guides KW - Child Care KW - Supported Employment KW - Block Grants KW - Grantsmanship KW - Tribes KW - Partnerships in Education KW - Money Management KW - Family Programs KW - Program Implementation KW - Federal Programs KW - American Indian Studies KW - Disadvantaged KW - Technical Assistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881462028?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - A regulatory perspective on the role of drug interactions in antiretroviral drug development. AN - 733326991; 19372986 AB - To provide a regulatory perspective on the role of drug interaction information in the development of antiretroviral drugs. Additionally, this review highlights novel studies that provided important information for the safe and effective use of antiretroviral medications. The management of drug interactions in HIV therapy becomes more complex with the introduction of each new drug because many antiretroviral drugs are involved in multiple metabolic and transporter-based interactions. Therefore, a comprehensive preclinical evaluation to characterize a new drug's metabolic pathway(s) followed by in-vivo studies is critical for the safe use of combination antiretroviral therapy. This review highlights published studies to illustrate several clinical and regulatory issues for in-vivo drug interaction studies such as general design issues, study-population selection, study-design options, use of historical controls and interpretation of results. Early identification of potential drug interactions can help identify and prioritize clinically important interaction studies essential to the overall development process. Understanding the clinical implications and management of drug interactions can lead to more effective long-term therapy, reduce toxicity, and delay the development of resistance. JF - Current opinion in HIV and AIDS AU - Struble, Kimberly A AU - Reynolds, Kellie Schoolar AD - Office of New Drugs, Division of Antiviral Products, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. kimberly.struble@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 325 EP - 329 VL - 3 IS - 3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733326991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+HIV+and+AIDS&rft.atitle=A+regulatory+perspective+on+the+role+of+drug+interactions+in+antiretroviral+drug+development.&rft.au=Struble%2C+Kimberly+A%3BReynolds%2C+Kellie+Schoolar&rft.aulast=Struble&rft.aufirst=Kimberly&rft.date=2008-05-01&rft.volume=3&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+HIV+and+AIDS&rft.issn=1746-6318&rft_id=info:doi/10.1097%2FCOH.0b013e3282f5f509 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-16 N1 - Date created - 2009-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/COH.0b013e3282f5f509 ER - TY - JOUR T1 - Approaches to establish thresholds for major food allergens and for gluten in food. AN - 71658338; 18522044 JF - Journal of food protection AU - Buchanan, Robert AU - Dennis, Sherri AU - Gendel, Steven AU - Acheson, David AU - Assimon, Sue Anne AU - Beru, Nega AU - Bolger, Philip AU - Carlson, David AU - Carvajal, Ricardo AU - Copp, Catherine AU - Falci, Kenneth AU - Garber, Eric AU - Harden, Elizabeth AU - Kane, Rhonda AU - Kvenberg, John AU - Luccioli, Stefano AU - Park, Douglas AU - Raybourne, Richard AU - Troxell, Terry AU - Vierk, Katherine AU - Threshold Working Group AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20740-3835, USA. ; Threshold Working Group Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1043 EP - 1088 VL - 71 IS - 5 SN - 0362-028X, 0362-028X KW - Allergens KW - 0 KW - Glutens KW - 8002-80-0 KW - Index Medicus KW - Food Labeling KW - Humans KW - Food Hypersensitivity -- prevention & control KW - Celiac Disease -- diet therapy KW - Food Analysis -- standards KW - Food Analysis -- methods KW - Consumer Product Safety KW - Glutens -- analysis KW - Food Contamination -- analysis KW - Allergens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71658338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Approaches+to+establish+thresholds+for+major+food+allergens+and+for+gluten+in+food.&rft.au=Buchanan%2C+Robert%3BDennis%2C+Sherri%3BGendel%2C+Steven%3BAcheson%2C+David%3BAssimon%2C+Sue+Anne%3BBeru%2C+Nega%3BBolger%2C+Philip%3BCarlson%2C+David%3BCarvajal%2C+Ricardo%3BCopp%2C+Catherine%3BFalci%2C+Kenneth%3BGarber%2C+Eric%3BHarden%2C+Elizabeth%3BKane%2C+Rhonda%3BKvenberg%2C+John%3BLuccioli%2C+Stefano%3BPark%2C+Douglas%3BRaybourne%2C+Richard%3BTroxell%2C+Terry%3BVierk%2C+Katherine%3BThreshold+Working+Group&rft.aulast=Buchanan&rft.aufirst=Robert&rft.date=2008-05-01&rft.volume=71&rft.issue=5&rft.spage=1043&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-08 N1 - Date created - 2008-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 mice. AN - 70485524; 18252804 AB - Perfluorinated alkyl acids (PFAAs) are used in a multitude of applications and are categorized as high-production volume chemicals produced in quantities exceeding 10,000 lbs/year. As a result, widespread exposure has been documented in adults, children, and infants. It is generally accepted that children are more sensitive to the effects of xenobiotic exposures during fetal and postnatal periods of development; therefore, considerable efforts are required to investigate the potential impact of a model PFAA, perfluorooctane sulfonate (PFOS) on children's immunological health. Using the pairing of female C57BL/6N mice with male C3H/HeJ, developmental immunotoxicity was evaluated in B6C3F1 pups following oral maternal exposure to PFOS on gestations days 1-17. Exposure levels included 0.1, 1, and 5 mg/kg/day PFOS. Natural killer (NK) cell activity, SRBC IgM plaque assay, CD4/8 lymphocytic subpopulations, nitrite production in peritoneal macrophages, and body/organ weights were evaluated at 4 and 8 weeks of age in F1 pups. No significant dose-responsive changes in maternal or pup body weights, flow cytometry, or macrophage function were observed, yet hepatomegaly was indicated in F1 male pups at 4 weeks of age. Functional deficits were not evident until 8 weeks of age when NK cell function and IgM production were significantly decreased. When compared with females, male pups were more sensitive to the effects of PFOS thereby establishing a no observed adverse effect level and low observed adverse effect level of 0.1 and 1.0 mg/kg/day (males only) following maternal PFOS exposure level, respectively. This study establishes that the developing immune system is sensitive to the effects of PFOS and results in functional deficits in innate and humoral immunity detectable at adulthood. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Keil, Deborah E AU - Mehlmann, Tracey AU - Butterworth, Leon AU - Peden-Adams, Margie M AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. deborah.keil@unlv.edu Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 77 EP - 85 VL - 103 IS - 1 KW - Alkanesulfonic Acids KW - 0 KW - Fluorocarbons KW - perfluorooctane sulfonic acid KW - 9H2MAI21CL KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Mice KW - Flow Cytometry KW - Male KW - Female KW - Pregnancy KW - Immunity, Innate -- drug effects KW - Alkanesulfonic Acids -- toxicity KW - Fluorocarbons -- toxicity KW - Maternal Exposure KW - Antibody Formation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70485524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Gestational+exposure+to+perfluorooctane+sulfonate+suppresses+immune+function+in+B6C3F1+mice.&rft.au=Keil%2C+Deborah+E%3BMehlmann%2C+Tracey%3BButterworth%2C+Leon%3BPeden-Adams%2C+Margie+M&rft.aulast=Keil&rft.aufirst=Deborah&rft.date=2008-05-01&rft.volume=103&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfn015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-08 N1 - Date created - 2008-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfn015 ER - TY - JOUR T1 - Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells. AN - 70453801; 18069091 AB - Parkinson's disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons with unknown etiology. MPP+ (1-methyl-4-phenylpyridinium ion) is the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which induces Parkinson's-like symptoms in humans and animals. MPTP/MPP+ produces selective dopaminergic neuronal degeneration, therefore, these agents are commonly used to study the pathogenesis of PD. However, the mechanisms of their toxicity have not been fully elucidated. Recently, we reported in a microarray study using a midbrain-derived dopaminergic neuronal cell line, MN9D, that MPP+ induced significant changes in a number of genes known to be associated with the dopaminergic system. In this study, we investigated the expression time courses of six genes using real-time RT-PCR, and compared them with the progressive dopaminergic depletion caused by MPP+. Our data showed that dopamine content was significantly decreased after 0.5h of MPP+ (200 microM) exposure and was completely depleted after 40 h. The expression of Gpr37, which is closely related to the pathogenesis of autosomal recessive juvenile Parkinsonism, was up-regulated after 0.5h, and stayed up-regulated up to 48 h. Txnip, which is critical to the adjustment of cellular redox status, was down-regulated after 1h and stayed down-regulated up to 48 h. Ldh1 and Cdo1, which are also involved in oxidative stress, were down-regulated after 16 h and stayed down-regulated up to 48 h. Two pro-apoptotic genes, Egln3 and Bnip3, were down-regulated after 2 and 4h, and stayed down-regulated up to 48 h. These findings suggested that the time course of expression for multiple genes correlated with the dopaminergic depletion; and MPP+-induced neurotoxicity in MN9D cells could be used as a model to further explore the roles of these and other genes in the pathogenesis and possible treatment of PD. JF - Neurochemistry international AU - Wang, Jianyong AU - Duhart, Helen M AU - Xu, Zengjun AU - Patterson, Tucker A AU - Newport, Glenn D AU - Ali, Syed F AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. jianyong.wang@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1037 EP - 1043 VL - 52 IS - 6 SN - 0197-0186, 0197-0186 KW - BNip3 protein, mouse KW - 0 KW - Carrier Proteins KW - DNA-Binding Proteins KW - Gpr37 protein, mouse KW - Herbicides KW - Immediate-Early Proteins KW - Isoenzymes KW - Membrane Proteins KW - Mitochondrial Proteins KW - RNA, Messenger KW - Receptors, G-Protein-Coupled KW - Txnip protein, mouse KW - Thioredoxins KW - 52500-60-4 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - lactate dehydrogenase 1 KW - EC 1.1.1.27.- KW - Egln3 protein, rat KW - EC 1.14.11.29 KW - Hypoxia-Inducible Factor-Proline Dioxygenases KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Carrier Proteins -- genetics KW - RNA, Messenger -- drug effects KW - Thioredoxins -- genetics KW - DNA-Binding Proteins -- genetics KW - Disease Progression KW - Substantia Nigra -- drug effects KW - Mitochondrial Proteins -- genetics KW - Mice KW - Membrane Proteins -- genetics KW - Isoenzymes -- genetics KW - Substantia Nigra -- metabolism KW - Substantia Nigra -- physiopathology KW - Immediate-Early Proteins -- genetics KW - RNA, Messenger -- metabolism KW - Down-Regulation -- genetics KW - L-Lactate Dehydrogenase -- genetics KW - Receptors, G-Protein-Coupled -- genetics KW - Herbicides -- toxicity KW - Down-Regulation -- drug effects KW - Time Factors KW - Cell Line KW - Parkinsonian Disorders -- physiopathology KW - Neurons -- metabolism KW - Dopamine -- deficiency KW - 1-Methyl-4-phenylpyridinium -- toxicity KW - Neurons -- drug effects KW - Gene Expression Regulation -- drug effects KW - Parkinsonian Disorders -- metabolism KW - Parkinsonian Disorders -- genetics KW - Gene Expression Regulation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70453801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=Comparison+of+the+time+courses+of+selective+gene+expression+and+dopaminergic+depletion+induced+by+MPP%2B+in+MN9D+cells.&rft.au=Wang%2C+Jianyong%3BDuhart%2C+Helen+M%3BXu%2C+Zengjun%3BPatterson%2C+Tucker+A%3BNewport%2C+Glenn+D%3BAli%2C+Syed+F&rft.aulast=Wang&rft.aufirst=Jianyong&rft.date=2008-05-01&rft.volume=52&rft.issue=6&rft.spage=1037&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-28 N1 - Date created - 2008-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimating the coverage of a targeted mobile tuberculosis screening programme among illicit drug users and homeless persons with truncated models. AN - 70430470; 17631692 AB - Truncated models are indirect methods to estimate the size of a hidden population which, in contrast to the capture-recapture method, can be used on a single information source. We estimated the coverage of a tuberculosis screening programme among illicit drug users and homeless persons with a mobile digital X-ray unit between 1 January 2003 and 31 December 2005 in Rotterdam, The Netherlands, using truncated models. The screening programme reached about two-third of the estimated target population at least once annually. The intended coverage (at least two chest X-rays per person per year) was about 23%. We conclude that simple truncated models can be used relatively easily on available single-source routine data to estimate the size of a population of illicit drug users and homeless persons. We assumed that the most likely overall bias in this study would be overestimation and therefore the coverage of the targeted mobile tuberculosis screening programme would be higher. JF - Epidemiology and infection AU - van Hest, N A H AU - De Vries, G AU - Smit, F AU - Grant, A D AU - Richardus, J H AD - Tuberculosis Control Section, Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands. vanhestr@ggd.rotterdam.nl Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 628 EP - 635 VL - 136 IS - 5 SN - 0950-2688, 0950-2688 KW - Street Drugs KW - 0 KW - Index Medicus KW - Radiography, Thoracic -- utilization KW - Humans KW - Substance-Related Disorders KW - Models, Statistical KW - Netherlands KW - Homeless Persons KW - Health Services Research KW - Tuberculosis -- diagnosis KW - Mobile Health Units KW - Mass Screening -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70430470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+infection&rft.atitle=Estimating+the+coverage+of+a+targeted+mobile+tuberculosis+screening+programme+among+illicit+drug+users+and+homeless+persons+with+truncated+models.&rft.au=van+Hest%2C+N+A+H%3BDe+Vries%2C+G%3BSmit%2C+F%3BGrant%2C+A+D%3BRichardus%2C+J+H&rft.aulast=van+Hest&rft.aufirst=N+A&rft.date=2008-05-01&rft.volume=136&rft.issue=5&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+infection&rft.issn=09502688&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-03-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 1992 May 1;135(9):1060-7 [1534441] Lancet. 1992 Mar 21;339(8795):742 [1347606] Am J Epidemiol. 1995 Nov 15;142(10):1047-58 [7485050] Am J Epidemiol. 1995 Nov 15;142(10):1059-68 [7485051] J Epidemiol Community Health. 1995 Dec;49(6):629-33 [8596100] Epidemiol Rev. 1995;17(2):243-64 [8654510] J Epidemiol Community Health. 1996 Aug;50(4):469-72 [8882234] JAMA. 1997 Oct 8;278(14):1159-63 [9326475] Am J Respir Crit Care Med. 1999 Jan;159(1):295-300 [9872853] Eur J Epidemiol. 2004;19(12):1075-83 [15678786] Int J Tuberc Lung Dis. 2005 May;9(5):528-33 [15875924] Eur J Public Health. 2006 Apr;16(2):133-6 [16230316] BMJ. 2006 Jul 8;333(7558):57-8 [16825208] Am J Respir Crit Care Med. 2007 Jul 15;176(2):201-7 [17413123] Epidemiol Infect. 2008 Jan;136(1):14-22 [17352840] Int J Tuberc Lung Dis. 1999 Nov;3(11):1001-8 [10587322] Stat Med. 2001 Oct 30;20(20):3123-57 [11590637] Eur J Epidemiol. 2001;17(2):123-8 [11599684] Eur J Epidemiol. 2001;17(10):935-42 [12188014] Int J Tuberc Lung Dis. 2003 Aug;7(8):751-7 [12921151] Arch Dis Child. 2004 Mar;89(3):222-4 [14977695] Am J Epidemiol. 1982 Jul;116(1):168-76 [6213145] Biometrics. 1987 Dec;43(4):783-91 [3427163] BMJ. 1994 Jan 1;308(6920):27-30 [8298348] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice. AN - 70426694; 18328611 AB - 3-Monochloropropane-1,2-diol (3-MCPD) is a food processing contaminant in a wide range of foods and ingredients and is a suspected cause of cancer. In this study, the 13-week toxicity of 3-MCPD was examined in B6C3F1 mice (10/sex/group) administered 3-MCPD doses of 0, 5, 25, 100, 200 and 400 ppm dissolved in their drinking water over a 13-week period. All the mice survived to the end of study. The mean body weight gains in the males and females given 400 ppm were significantly lower than those of the controls. The relative kidney weights of the males and females given 200 and 400 ppm were significantly higher than those of the controls without any corresponding histopathological changes. The sperm motility was lower in the 400 ppm group than the control, and there was a significant increase in the incidence of germinal epithelium degeneration in the 200 and 400 ppm groups. A delayed total estrus cycle length was observed in the 400 ppm group without any histopathological changes. Based on these results, the target organ was determined to be kidney, testis, and ovary. The no-observed-adverse-effect level (NOAEL) was found to be 100 ppm (18.05 mg/kg/day for males and 15.02 mg/kg/day for females). JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Cho, Wan-Seob AU - Han, Beom Seok AU - Lee, Hakyung AU - Kim, Cheulkyu AU - Nam, Ki Taek AU - Park, Kidae AU - Choi, Mina AU - Kim, Sung Jun AU - Kim, Seung Hee AU - Jeong, Jayoung AU - Jang, Dong Deuk AD - Division of Toxicologic Pathology, Department of Toxicological Research, Korea Food and Drug Administration, National Institute of Toxicological Research, Korea FDA, Eunpyung-Ku, Seoul, Republic of Korea. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1666 EP - 1673 VL - 46 IS - 5 SN - 0278-6915, 0278-6915 KW - Water KW - 059QF0KO0R KW - alpha-Chlorohydrin KW - 96-24-2 KW - Glycerol KW - PDC6A3C0OX KW - Index Medicus KW - Vagina -- drug effects KW - Administration, Oral KW - Animals KW - Blood Chemical Analysis KW - Vagina -- cytology KW - Sex Characteristics KW - Survival KW - Mice KW - Sperm Motility -- drug effects KW - Blood Cell Count KW - Mice, Inbred Strains KW - No-Observed-Adverse-Effect Level KW - Body Weight -- drug effects KW - Female KW - Growth -- drug effects KW - Male KW - Organ Size -- drug effects KW - Glycerol -- analogs & derivatives KW - Glycerol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70426694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Subchronic+toxicity+study+of+3-monochloropropane-1%2C2-diol+administered+by+drinking+water+to+B6C3F1+mice.&rft.au=Cho%2C+Wan-Seob%3BHan%2C+Beom+Seok%3BLee%2C+Hakyung%3BKim%2C+Cheulkyu%3BNam%2C+Ki+Taek%3BPark%2C+Kidae%3BChoi%2C+Mina%3BKim%2C+Sung+Jun%3BKim%2C+Seung+Hee%3BJeong%2C+Jayoung%3BJang%2C+Dong+Deuk&rft.aulast=Cho&rft.aufirst=Wan-Seob&rft.date=2008-05-01&rft.volume=46&rft.issue=5&rft.spage=1666&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2007.12.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2007.12.030 ER - TY - JOUR T1 - Determination of aflatoxins B1, B2, G1, and G2 and ochratoxin A in ginseng and ginger by multitoxin immunoaffinity column cleanup and liquid chromatographic quantitation: collaborative study. AN - 69233577; 18567295 AB - The accuracy, repeatability, and reproducibility characteristics of a method using multitoxin immunoaffinity column cleanup with liquid chromatography (LC) for determination of aflatoxins (AF; sum of aflatoxins B1, B2, G1, and G2) and ochratoxin A (OTA) in powdered ginseng and ginger have been established in a collaborative study involving 13 laboratories from 7 countries. Blind duplicate samples of blank, spiked (AF and OTA added) at levels ranging from 0.25 to 16.0 microg/kg for AF and 0.25 to 8.0 microg/kg for OTA were analyzed. A naturally contaminated powdered ginger sample was also included. Test samples were extracted with methanol and 0.5% aqueous sodium hydrogen carbonate solution (700 + 300, v/v). The extract was centrifuged, diluted with phosphate buffer (PB), filtered, and applied to an immunoaffinity column containing antibodies specific for AF and OTA. After washing the column with water, the toxins were eluted from the column with methanol, and quantified by high-performance LC with fluorescence detection. Average recoveries of AF from ginseng and ginger ranged from 70 to 87% (at spiking levels ranging from 2 to 16 microg/kg), and of OTA, from 86 to 113% (at spiking levels ranging from 1 to 8 microg/kg). Relative standard deviations for within-laboratory repeatability (RSDr) ranged from 2.6 to 8.3% for AF, and from 2.5 to 10.7% for OTA. Relative standard deviations for between-laboratory reproducibility (RSDR) ranged from 5.7 to 28.6% for AF, and from 5.5 to 10.7% for OTA. HorRat values were < or = 2 for the multi-analytes in the 2 matrixes. JF - Journal of AOAC International AU - Trucksess, Mary W AU - Weaver, Carol M AU - Oles, Carolyn J AU - Fry, Frederick S AU - Noonan, Gregory O AU - Betz, Joseph M AU - Rader, Jeanne I AD - U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. mary.trucksess@fda.hhs.gov PY - 2008 SP - 511 EP - 523 VL - 91 IS - 3 SN - 1060-3271, 1060-3271 KW - Aflatoxins KW - 0 KW - Indicators and Reagents KW - Ochratoxins KW - ochratoxin A KW - 1779SX6LUY KW - aflatoxin G2 KW - 2MS0D8WA29 KW - aflatoxin B2 KW - 7SKR7S646P KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Cooperative Behavior KW - Reference Standards KW - Aflatoxin B1 -- analysis KW - Ochratoxins -- analysis KW - Aflatoxins -- analysis KW - Chromatography, Liquid -- methods KW - Panax -- chemistry KW - Ochratoxins -- standards KW - Chromatography, Affinity -- standards KW - Ginger -- chemistry KW - Aflatoxins -- standards KW - Chromatography, Liquid -- standards KW - Chromatography, Affinity -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69233577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determination+of+aflatoxins+B1%2C+B2%2C+G1%2C+and+G2+and+ochratoxin+A+in+ginseng+and+ginger+by+multitoxin+immunoaffinity+column+cleanup+and+liquid+chromatographic+quantitation%3A+collaborative+study.&rft.au=Trucksess%2C+Mary+W%3BWeaver%2C+Carol+M%3BOles%2C+Carolyn+J%3BFry%2C+Frederick+S%3BNoonan%2C+Gregory+O%3BBetz%2C+Joseph+M%3BRader%2C+Jeanne+I&rft.aulast=Trucksess&rft.aufirst=Mary&rft.date=2008-05-01&rft.volume=91&rft.issue=3&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Food Prot. 2001 Aug;64(8):1268-70 [11510675] Anal Bioanal Chem. 2007 Sep;389(1):27-35 [17390125] J Assoc Off Anal Chem. 1991 Sep-Oct;74(5):718-44 [1783583] Food Addit Contam. 1996 Jan;13(1):121-8 [8647302] Food Addit Contam. 2005 Feb;22(2):163-72 [15824007] J AOAC Int. 2006 May-Jun;89(3):624-30 [16792061] J Agric Food Chem. 2006 Jul 26;54(15):5688-93 [16848564] J AOAC Int. 2007 Jul-Aug;90(4):1042-9 [17760342] J AOAC Int. 2006 Jul-Aug;89(4):1095-109 [16915851] Exp Biol Med (Maywood). 2004 Jun;229(6):560-8 [15169976] Microbiol Res. 2004;159(2):113-20 [15293944] J Food Prot. 2004 Aug;67(8):1782-6 [15330551] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry. AN - 69233150; 18567304 AB - Two analogs of sildenafil and vardenafil in food were detected by column liquid chromatography (LC) with a photodiode array detector. They were isolated by preparative LC; their structures were established by mass spectrometry and nuclear magnetic resonance spectrometry. One analog was found to be methisosildenafil (compound A), 5-(5-(3,5-dimethylpiperazin-1-ylsulfonyl)-2-ethoxy-phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]-pyrimidin-7(6H)-one. It is a sildenafil analog with a dimethylpiperazine ring substituted for the methylpiperazine group. The second analog, hydroxyvardenafil (compound B) is reported for the first time in this study. Hydroxyvardenafil's International Union of Pure and Applied Chemistry name is 2-(2-ethoxy-5-(4-(2-hydroxyethyl)-piperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propyl-imidazo[1,5-f][1,2,4]triazin-4(3H)-one. The novel vardenafil analog has a hydroxyl group added to the ethylpiperazine group. JF - Journal of AOAC International AU - Choi, Dong Mi AU - Park, Sangaeh AU - Yoon, Tae Hyung AU - Jeong, Hye Kyoung AU - Pyo, Jae Sung AU - Park, Janghyun AU - Kim, Deukjoon AU - Kwon, Sung Won AD - Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul 122704, Korea. PY - 2008 SP - 580 EP - 588 VL - 91 IS - 3 SN - 1060-3271, 1060-3271 KW - Imidazoles KW - 0 KW - Phosphodiesterase Inhibitors KW - Piperazines KW - Purines KW - Sulfones KW - Triazines KW - Vardenafil Dihydrochloride KW - 5O8R96XMH7 KW - Sildenafil Citrate KW - BW9B0ZE037 KW - Index Medicus KW - Molecular Structure KW - Purines -- standards KW - Triazines -- analysis KW - Phosphodiesterase Inhibitors -- standards KW - Reference Standards KW - Phosphodiesterase Inhibitors -- chemistry KW - Triazines -- standards KW - Phosphodiesterase Inhibitors -- analysis KW - Purines -- chemistry KW - Purines -- analysis KW - Triazines -- chemistry KW - Sulfones -- chemistry KW - Imidazoles -- standards KW - Piperazines -- chemistry KW - Food Contamination -- analysis KW - Piperazines -- standards KW - Imidazoles -- analysis KW - Mass Spectrometry -- standards KW - Sulfones -- standards KW - Magnetic Resonance Spectroscopy -- standards KW - Chromatography, Liquid -- methods KW - Magnetic Resonance Spectroscopy -- methods KW - Mass Spectrometry -- methods KW - Chromatography, Liquid -- standards KW - Piperazines -- analysis KW - Sulfones -- analysis KW - Imidazoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69233150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determination+of+analogs+of+sildenafil+and+vardenafil+in+foods+by+column+liquid+chromatography+with+a+photodiode+array+detector%2C+mass+spectrometry%2C+and+nuclear+magnetic+resonance+spectrometry.&rft.au=Choi%2C+Dong+Mi%3BPark%2C+Sangaeh%3BYoon%2C+Tae+Hyung%3BJeong%2C+Hye+Kyoung%3BPyo%2C+Jae+Sung%3BPark%2C+Janghyun%3BKim%2C+Deukjoon%3BKwon%2C+Sung+Won&rft.aulast=Choi&rft.aufirst=Dong&rft.date=2008-05-01&rft.volume=91&rft.issue=3&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration? AN - 69200859; 18470306 AB - Parkinson disease (PD), a chronic neurodegenerative disease, has been proposed to be a multifactorial disorder resulting from a combination of environmental mechanisms (chemical, infectious, and traumatic), aging, and genetic deficits. Microglial activation is important in the pathogenesis of PD. We investigated dopaminergic (DA) neurotoxicity and the underlying mechanisms of formyl-methionyl-leucyl-phenylalanine (fMLP), a bacteria-derived peptide, in relation to PD. We measured DA neurotoxicity using a DA uptake assay and immunocytochemical staining (ICC) in primary mesencephalic cultures from rodents. Microglial activation was observed via ICC, flow cytometry, and superoxide measurement. fMLP can cause selective DA neuronal loss at concentrations as low as 10(-13) M. Further, fMLP (10(-13) M) led to a significant reduction in DA uptake capacity in neuron/glia (N/G) cultures, but not in microglia-depleted cultures, indicating an indispensable role of microglia in fMLP-induced neurotoxicity. Using ICC of a specific microglial marker, OX42, we observed morphologic changes in activated microglia after fMLP treatment. Microglial activation after fMLP treatment was confirmed by flow cytometry analysis of major histocompatibility antigen class II expression on a microglia HAPI cell line. Mechanistic studies revealed that fMLP (10(-13) M)-induced increase in the production of extracellular superoxide from microglia is critical in mediating fMLP-elicited neurotoxicity. Pharmacologic inhibition of NADPH oxidase (PHOX) with diphenylene-iodonium or apocynin abolished the DA neurotoxicity of fMLP. N/G cultures from PHOX-deficient (gp91PHOX-/ -) mice were also insensitive to fMLP-induced DA neurotoxicity. fMLP (10(-13) M) induces DA neurotoxicity through activation of microglial PHOX and subsequent production of superoxide, suggesting a role of fMLP in the central nervous system inflammatory process. JF - Environmental health perspectives AU - Gao, Xi AU - Hu, Xiaoming AU - Qian, Li AU - Yang, Sufen AU - Zhang, Wei AU - Zhang, Dan AU - Wu, Xuefei AU - Fraser, Alison AU - Wilson, Belinda AU - Flood, Patrick M AU - Block, Michelle AU - Hong, Jau-Shyong AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 593 EP - 598 VL - 116 IS - 5 SN - 0091-6765, 0091-6765 KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - inflammation KW - microglia KW - neurotoxicity KW - fMLP KW - NADPH oxidase KW - NADPH Oxidase -- metabolism KW - Animals KW - Neurons -- metabolism KW - Enzyme Activation KW - Neurons -- drug effects KW - Mice KW - Mice, Knockout KW - Pregnancy KW - Rats KW - Rats, Inbred F344 KW - Cells, Cultured KW - Oxidative Stress KW - Mice, Inbred C57BL KW - Female KW - Parkinson Disease -- etiology KW - Neurodegenerative Diseases -- chemically induced KW - Microglia -- enzymology KW - Central Nervous System Infections -- metabolism KW - Central Nervous System Infections -- etiology KW - Neurodegenerative Diseases -- metabolism KW - Neurodegenerative Diseases -- pathology KW - Dopamine -- metabolism KW - N-Formylmethionine Leucyl-Phenylalanine -- toxicity KW - Microglia -- drug effects KW - Central Nervous System Infections -- pathology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69200859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Formyl-methionyl-leucyl-phenylalanine-induced+dopaminergic+neurotoxicity+via+microglial+activation%3A+a+mediator+between+peripheral+infection+and+neurodegeneration%3F&rft.au=Gao%2C+Xi%3BHu%2C+Xiaoming%3BQian%2C+Li%3BYang%2C+Sufen%3BZhang%2C+Wei%3BZhang%2C+Dan%3BWu%2C+Xuefei%3BFraser%2C+Alison%3BWilson%2C+Belinda%3BFlood%2C+Patrick+M%3BBlock%2C+Michelle%3BHong%2C+Jau-Shyong&rft.aulast=Gao&rft.aufirst=Xi&rft.date=2008-05-01&rft.volume=116&rft.issue=5&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Histol Histopathol. 2006 Jun;21(6):673-8 [16528677] Blood. 1996 Jul 15;88(2):690-6 [8695817] J Biochem. 2006 Nov;140(5):739-45 [17030506] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] J Immunol. 2007 Feb 1;178(3):1759-66 [17237425] Glia. 2007 Apr 1;55(5):453-62 [17203472] Brain Res. 2007 Mar 23;1138:196-202 [17275793] J Am Acad Nurse Pract. 2007 Apr;19(4):179-97 [17430539] Neurosci Lett. 1996 Jun 14;211(1):13-6 [8809836] Ann Neurol. 1998 Sep;44(3 Suppl 1):S115-20 [9749582] Blood. 1999 Mar 1;93(5):1464-76 [10029572] Immunopharmacol Immunotoxicol. 1999 Aug;21(3):397-419 [10466071] J Exp Med. 1999 Sep 6;190(5):741-7 [10477558] Ann Neurol. 2005 Feb;57(2):176-9 [15668963] FASEB J. 2005 Apr;19(6):550-7 [15791005] FASEB J. 2006 Feb;20(2):251-8 [16449797] J Neural Transm Suppl. 2007;(72):113-20 [17982884] Brain Res Rev. 2007 Nov;56(1):119-47 [17659349] J Biol Chem. 2008 Mar 21;283(12):7983-93 [18160398] Br J Pharmacol. 1998 Nov;125(5):1109-14 [9846652] J Pharmacol Exp Ther. 2000 May;293(2):607-17 [10773035] Neurobiol Aging. 2000 May-Jun;21(3):463-73 [10858596] Immunol Rev. 2000 Oct;177:185-94 [11138775] J Pharmacol Exp Ther. 2001 Sep;298(3):1133-41 [11504811] Neural Plast. 2001;8(1-2):99-110 [11530892] J Immunol. 2002 Jan 1;168(1):434-42 [11751990] Neuroscience. 2002;112(1):7-11 [12044467] J Neurochem. 2002 Jun;81(6):1285-97 [12068076] Ann N Y Acad Sci. 2002 May;962:318-31 [12076984] Neurobiol Dis. 2002 Aug;10(3):366-77 [12270697] J Neurochem. 2002 Nov;83(4):973-83 [12421370] Nat Rev Neurosci. 2003 Feb;4(2):103-12 [12563281] Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8 [12666096] Scand J Immunol. 2004 Jan;59(1):25-33 [14723618] Immunology. 2004 Jun;112(2):201-10 [15147563] Drugs. 2004;64(19):2143-57 [15456332] Biochem Biophys Res Commun. 1985 Apr 16;128(1):297-304 [2985075] Neurology. 1988 Aug;38(8):1285-91 [3399080] J Neurosci Res. 1990 Sep;27(1):36-42 [2254955] Blood. 1993 Jul 15;82(2):633-40 [8329716] Nature. 1993 Aug 12;364(6438):584 [8350919] Ann Neurol. 1994;36 Suppl:S25-8 [8017885] J Pharmacol Exp Ther. 2006 Nov;319(2):595-603 [16891616] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.11031 ER - TY - JOUR T1 - Adolescent use of insulin and patient-controlled analgesia pump technology: a 10-year Food and Drug Administration retrospective study of adverse events. AN - 69173873; 18450857 AB - From January 1, 2005, through December 31, 2005, the Food and Drug Administration received 5 adolescent death reports associated with the use of insulin pumps, raising concerns about use of this device in this age group. To understand better the types of infusion pump-related problems in adolescents, we performed a comprehensive evaluation of insulin and patient-controlled analgesic pump-related adverse events reported for adolescents that were received by the Food and Drug Administration from 1996 to 2005. A search for medical device adverse event reports from January 1, 1996 through December 31, 2005, involving insulin pumps or patient-controlled analgesic pumps used by patients who were aged 12 to 21 years was conducted in the Food and Drug Administration's Manufacturer and User Facility Device Experience Database. Reports were reviewed for demographic characteristics, type of adverse event, and patient morbidity, and potential contributory factors were classified from narratives in the reports. A total of 1674 reports were identified: 1594 for insulin pumps and 53 for patient-controlled analgesic pumps. In reports of insulin pump events, there were 13 reported deaths, 2 reports that indicated possible suicide attempts, and several additional reports indicating severe hypoglycemic or hyperglycemic events that seemed to be device-related. A total of 102 (6.4%) insulin-pump reports highlighted factors that may have contributed to the adverse event, including problems associated with compliance, education, sports-related activities, and dropping or damaging the pump. Eighty-two percent of cases involving the insulin pump resulted in hospitalization. Half of the reports involving patient-controlled analgesic pumps indicated that the patient received an excess of medication; tampering and noncompliance were evident in some cases. Adolescents are a special population who deserve careful consideration of risk and benefit for use of device technology. Studies need to further identify safety problems in this age group. JF - Pediatrics AU - Cope, Judith U AU - Morrison, Audrey E AU - Samuels-Reid, Joy AD - Division of Postmarket Surveillance, Office of Surveillance and Biometrics, Food and Drug Administration, Rockville, Maryland 20850, USA. Judith.cope@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - e1133 EP - e1138 VL - 121 IS - 5 KW - Abridged Index Medicus KW - Index Medicus KW - Hypoglycemia -- etiology KW - Adolescent Behavior KW - Humans KW - Adult KW - Psychology, Adolescent KW - Hyperglycemia -- etiology KW - Child KW - Equipment Failure KW - Adolescent KW - Male KW - Female KW - Insulin Infusion Systems -- adverse effects KW - Analgesia, Patient-Controlled -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69173873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Adolescent+use+of+insulin+and+patient-controlled+analgesia+pump+technology%3A+a+10-year+Food+and+Drug+Administration+retrospective+study+of+adverse+events.&rft.au=Cope%2C+Judith+U%3BMorrison%2C+Audrey+E%3BSamuels-Reid%2C+Joy&rft.aulast=Cope&rft.aufirst=Judith&rft.date=2008-05-01&rft.volume=121&rft.issue=5&rft.spage=e1133&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2007-1707 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-04 N1 - Date created - 2008-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Pediatrics. 2008 Sep;122(3):682; author reply 682-3 [18762546] Pediatrics. 2008 Aug;122(2):473-4; author reply 474 [18676571] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.2007-1707 ER - TY - JOUR T1 - Multi-class, multi-residue liquid chromatography/tandem mass spectrometry screening and confirmation methods for drug residues in milk. AN - 69160256; 18412094 AB - This paper describes the development and optimization of a multi-residue veterinary drug screening method for whole milk. The drug residues of regulatory interest in milk include beta-lactams, sulfonamides, tetracyclines, fluoroquinolones, and macrolides. Milk samples were extracted with acetonitrile and the samples were then subjected to a clean-up procedure using a bonded solid-phase extraction cartridge and a molecular weight cut-off filter. Liquid chromatography/tandem mass spectrometry (LC/MS/MS) triple quadrupole electrospray methods were developed to monitor for the drugs in milk. Since established tolerance levels are set for most of these drugs in milk, the initial screening procedure was semi-quantitative, where samples were compared to the response of a positive control. The positive control, consisting of an extract from a portion of milk fortified with the drugs at half their allowed levels, was used to set the laboratory's minimum response criteria for unknown samples. Confirmatory analyses, with additional ion transitions for each residue, were performed on the same extracts. JF - Rapid communications in mass spectrometry : RCM AU - Turnipseed, Sherri B AU - Andersen, Wendy C AU - Karbiwnyk, Christine M AU - Madson, Mark R AU - Miller, Keith E AD - Animal Drugs Research Center, Food and Drug Administration, Denver Federal Center, Denver, CO 80225, USA. sherri.turnipseed@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1467 EP - 1480 VL - 22 IS - 10 SN - 0951-4198, 0951-4198 KW - Veterinary Drugs KW - 0 KW - Index Medicus KW - Animals KW - Cattle KW - Food Analysis -- methods KW - Veterinary Drugs -- analysis KW - Food Contamination -- analysis KW - Chromatography, High Pressure Liquid -- methods KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods KW - Milk -- chemistry KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69160256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Multi-class%2C+multi-residue+liquid+chromatography%2Ftandem+mass+spectrometry+screening+and+confirmation+methods+for+drug+residues+in+milk.&rft.au=Turnipseed%2C+Sherri+B%3BAndersen%2C+Wendy+C%3BKarbiwnyk%2C+Christine+M%3BMadson%2C+Mark+R%3BMiller%2C+Keith+E&rft.aulast=Turnipseed&rft.aufirst=Sherri&rft.date=2008-05-01&rft.volume=22&rft.issue=10&rft.spage=1467&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=09514198&rft_id=info:doi/10.1002%2Frcm.3532 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-10 N1 - Date created - 2008-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/rcm.3532 ER - TY - JOUR T1 - Implementing infrared determination of quartz particulates on novel filters for a prototype dust monitor. AN - 69158657; 18449405 AB - Research by the National Institute for Occupational Safety and Health (NIOSH) has pursued quartz analysis for the specialized filter assemblies of a new worker-wearable personal dust monitor (PDM). The PDM is a real-time instrument utilizing a tapered element oscillating microbalance (TEOM). Standard fiberglass TEOM filters cannot accommodate the desired P-7 infrared analytical method used by the Mine Safety and Health Administration (MSHA). Novel filter materials were tested with the objective of demonstrating this type of analysis. Low temperature ashing and spectrometric examination were employed, revealing that nylon fiber candidate filters left minimal residual ash and produced no significant spectral interference. Avoiding titanium dioxide in all filter materials proved to be a key requirement. Fine quartz particulates were collected on prototype filters in a Marple chamber, either open-faced or through PDMs during test runs. The filters were then subjected to MSHA P-7 analysis and the spectrometrically based analytical results for quartz mass were compared to reference measurements. Also, PDM instrumental mass readings were compared to filter gravimetric measurements. Results suggest that the P-7 method is adaptable to variations in filter materials and that quartz dust analysis by the P-7 method when utilizing the new ashable PDM filters can have accuracy and precision within 10% and 4%, respectively. This is within the declared 13% accuracy and 7-10% precision of the P-7 method itself. Instrument mass readings had modest positive bias but met NIOSH accuracy criteria. Continued work with specialized PDM filters is merited, as they are a new type of TEOM sample amenable to ashing analysis of particulates. JF - Journal of environmental monitoring : JEM AU - Tuchman, Donald P AU - Volkwein, Jon C AU - Vinson, Robert P AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 671 EP - 678 VL - 10 IS - 5 SN - 1464-0325, 1464-0325 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Quartz KW - 14808-60-7 KW - Index Medicus KW - Spectrophotometry, Infrared KW - Particle Size KW - Filtration -- instrumentation KW - Coal Mining KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Quartz -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69158657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Implementing+infrared+determination+of+quartz+particulates+on+novel+filters+for+a+prototype+dust+monitor.&rft.au=Tuchman%2C+Donald+P%3BVolkwein%2C+Jon+C%3BVinson%2C+Robert+P&rft.aulast=Tuchman&rft.aufirst=Donald&rft.date=2008-05-01&rft.volume=10&rft.issue=5&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb803804j LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-15 N1 - Date created - 2008-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/b803804j ER - TY - JOUR T1 - Risk of leukemia among survivors of testicular cancer: a population-based study of 42,722 patients. AN - 69124864; 18433667 AB - The aim of this study is to quantify excess absolute risk (EAR) and excess relative risk (ERR) of secondary leukemia among a large population-based group of testicular cancer survivors. We identified 42,722 1-year survivors of testicular cancer within 14 population-based cancer registries in Europe and North America (1943-2002). Poisson regression analysis was used to model EAR (per 100,000 person-years [PY]) and ERR of secondary leukemia. Cumulative risks were calculated using a competing risk model. Secondary leukemia developed in 89 patients (EAR = 10.8 per 100,000 PY, 95% confidence interval [CI] = 7.6-14.6; ERR = 1.6, 95%CI = 1.0-2.2). Statistically significantly elevated risks were observed for acute myeloid leukemia (AML) (EAR = 7.2, 95%CI = 4.7-10.2) and acute lymphoblastic leukemia (EAR = 1.3, 95%CI = 0.4-2.8). In multivariate analyses, AML risk was higher among patients whose initial management included chemotherapy compared to those receiving radiotherapy alone (p = 0.1). Excess cumulative leukemia risk was approximately 0.23% by 30 years after testicular cancer diagnosis. Although ERR of leukemia following testicular cancer is large, EAR and cumulative risk, which are better gauges of the population burden, are small. JF - Annals of epidemiology AU - Howard, Regan AU - Gilbert, Ethel AU - Lynch, Charles F AU - Hall, Per AU - Storm, Hans AU - Holowaty, Eric AU - Pukkala, Eero AU - Langmark, Froydis AU - Kaijser, Magnus AU - Andersson, Michael AU - Joensuu, Heikki AU - Fossa, Sophie D AU - Allan, James M AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. reganho@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 416 EP - 421 VL - 18 IS - 5 KW - Index Medicus KW - Registries KW - North America -- epidemiology KW - Humans KW - Cohort Studies KW - Adult KW - Middle Aged KW - Europe -- epidemiology KW - Male KW - Multivariate Analysis KW - Testicular Neoplasms -- therapy KW - Leukemia -- chemically induced KW - Neoplasms, Second Primary -- epidemiology KW - Leukemia -- epidemiology KW - Testicular Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69124864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+epidemiology&rft.atitle=Risk+of+leukemia+among+survivors+of+testicular+cancer%3A+a+population-based+study+of+42%2C722+patients.&rft.au=Howard%2C+Regan%3BGilbert%2C+Ethel%3BLynch%2C+Charles+F%3BHall%2C+Per%3BStorm%2C+Hans%3BHolowaty%2C+Eric%3BPukkala%2C+Eero%3BLangmark%2C+Froydis%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BJoensuu%2C+Heikki%3BFossa%2C+Sophie+D%3BAllan%2C+James+M%3BTravis%2C+Lois+B&rft.aulast=Howard&rft.aufirst=Regan&rft.date=2008-05-01&rft.volume=18&rft.issue=5&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Annals+of+epidemiology&rft.issn=1873-2585&rft_id=info:doi/10.1016%2Fj.annepidem.2008.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-04-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Jul 19;92(14):1165-71 [10904090] J Clin Oncol. 2007 Oct 1;25(28):4370-8 [17906202] J Clin Oncol. 1984 Oct;2(10):1080-7 [6092549] Acta Radiol Oncol. 1984;23(5):305-13 [6095600] Lancet. 1991 Aug 10;338(8763):359-63 [1713639] Int J Radiat Oncol Biol Phys. 1992;24(5):913-9 [1447034] J Natl Cancer Inst. 1993 Jan 6;85(1):36-40 [7677934] J Clin Oncol. 1993 Mar;11(3):415-24 [8445415] J Natl Cancer Inst. 1995 Jan 4;87(1):58-60 [7666466] J Natl Cancer Inst. 1997 Oct 1;89(19):1429-39 [9326912] Leukemia. 1999 Apr;13 Suppl 1:S37-41 [10232363] Expert Rev Anticancer Ther. 2005 Feb;5(1):123-38 [15757445] J Natl Cancer Inst. 2005 Sep 21;97(18):1354-65 [16174857] Lancet. 2006 Mar 4;367(9512):754-65 [16517276] Int J Cancer. 2007 Feb 1;120(3):623-31 [17096341] Br J Cancer. 2007 Feb 12;96(3):529-33 [17262080] Leuk Lymphoma. 2001 May;41(5-6):559-70 [11378573] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.annepidem.2008.01.003 ER - TY - JOUR T1 - Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. AN - 69110887; 18096873 AB - Carbon nanotubes (CNT), with their applications in industry and medicine, may lead to new risks to human health. CNT induce a robust pulmonary inflammation and oxidative stress in rodents. Realistic exposures to CNT may occur in conjunction with other pathogenic impacts (microbial infections) and trigger enhanced responses. We evaluated interactions between pharyngeal aspiration of single-walled CNT (SWCNT) and bacterial pulmonary infection of C57BL/6 mice with Listeria monocytogenes (LM). Mice were given SWCNT (0, 10, and 40 mug/mouse) and 3 days later were exposed to LM (10(3) bacteria/mouse). Sequential exposure to SWCNT/LM amplified lung inflammation and collagen formation. Despite this robust inflammatory response, SWCNT pre-exposure significantly decreased the pulmonary clearance of LM-exposed mice measured 3 to 7 days after microbial infection versus PBS/LM-treated mice. Decreased bacterial clearance in SWCNT-pre-exposed mice was associated with decreased phagocytosis of bacteria by macrophages and a decrease in nitric oxide production by these phagocytes. Pre-incubation of naïve alveolar macrophages with SWCNT in vitro also resulted in decreased nitric oxide generation and suppressed phagocytizing activity toward LM. Failure of SWCNT-exposed mice to clear LM led to a continued elevation in nearly all major chemokines and acute phase cytokines into the later course of infection. In SWCNT/LM-exposed mice, bronchoalveolar lavage neutrophils, alveolar macrophages, and lymphocytes, as well as lactate dehydrogenase level, were increased compared with mice exposed to SWCNT or LM alone. In conclusion, enhanced acute inflammation and pulmonary injury with delayed bacterial clearance after SWCNT exposure may lead to increased susceptibility to lung infection in exposed populations. JF - American journal of respiratory cell and molecular biology AU - Shvedova, Anna A AU - Fabisiak, James P AU - Kisin, Elena R AU - Murray, Ashley R AU - Roberts, Jenny R AU - Tyurina, Yulia Y AU - Antonini, James M AU - Feng, Wei Hong AU - Kommineni, Choudari AU - Reynolds, Jeffrey AU - Barchowsky, Aaron AU - Castranova, Vince AU - Kagan, Valerian E AD - Pathology/Physiology Research Branch, HELD, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. ats1@cdc.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 579 EP - 590 VL - 38 IS - 5 KW - Cytokines KW - 0 KW - Nanotubes, Carbon KW - Index Medicus KW - Bronchoalveolar Lavage Fluid -- immunology KW - Animals KW - Cytokines -- biosynthesis KW - Weight Loss KW - Mice, Inbred C57BL KW - Bronchoalveolar Lavage Fluid -- microbiology KW - Mice KW - Phagocytosis KW - Macrophages, Alveolar -- immunology KW - Female KW - Pneumonia -- chemically induced KW - Listeriosis -- pathology KW - Pneumonia -- microbiology KW - Listeriosis -- immunology KW - Lung -- pathology KW - Nanotubes, Carbon -- toxicity KW - Pneumonia -- pathology KW - Nanotubes, Carbon -- microbiology KW - Lung -- immunology KW - Listeria monocytogenes -- pathogenicity KW - Pneumonia -- immunology KW - Listeriosis -- physiopathology KW - Lung -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69110887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Sequential+exposure+to+carbon+nanotubes+and+bacteria+enhances+pulmonary+inflammation+and+infectivity.&rft.au=Shvedova%2C+Anna+A%3BFabisiak%2C+James+P%3BKisin%2C+Elena+R%3BMurray%2C+Ashley+R%3BRoberts%2C+Jenny+R%3BTyurina%2C+Yulia+Y%3BAntonini%2C+James+M%3BFeng%2C+Wei+Hong%3BKommineni%2C+Choudari%3BReynolds%2C+Jeffrey%3BBarchowsky%2C+Aaron%3BCastranova%2C+Vince%3BKagan%2C+Valerian+E&rft.aulast=Shvedova&rft.aufirst=Anna&rft.date=2008-05-01&rft.volume=38&rft.issue=5&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=1535-4989&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-06 N1 - Date created - 2008-04-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2002 Nov;70(1):110-9 [12388840] Int Arch Occup Environ Health. 2008 May;81(6):721-6 [17849141] J Immunol. 2003 May 1;170(9):4457-64 [12707321] Toxicol Sci. 2003 May;73(1):66-71 [12700415] Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7812-7 [12810961] J Toxicol Environ Health A. 2003 Aug 8;66(15):1441-52 [12857634] J Nanosci Nanotechnol. 2003 Feb-Apr;3(1-2):63-73 [12908231] J Toxicol Environ Health A. 2004 Jan 9;67(1):87-107 [14668113] Biomaterials. 2004 May;25(12):2399-407 [14741605] Curr Mol Med. 2004 Sep;4(6):681-9 [15357216] Nat Rev Immunol. 2004 Oct;4(10):812-23 [15459672] Toxicol Appl Pharmacol. 2004 Nov 1;200(3):206-18 [15504457] Cell. 1993 May 7;73(3):457-67 [8387893] Clin Immunol Immunopathol. 1994 Sep;72(3):283-92 [7914840] J Appl Physiol (1985). 1994 Sep;77(3):1060-6 [7836104] Eur J Immunol. 1995 Jan;25(1):200-6 [7843232] Environ Health Perspect. 1994 Dec;102 Suppl 10:37-42 [7705302] Immunity. 1995 Jul;3(1):109-17 [7621071] Immunity. 1997 Sep;7(3):419-32 [9324362] Anal Chem. 1998 Jul 1;70(13):2446-53 [9666719] Immunity. 1999 Jan;10(1):29-38 [10023768] Am J Respir Cell Mol Biol. 1999 Apr;20(4):561-72 [10100987] Am J Respir Cell Mol Biol. 2005 Jul;33(1):97-104 [15845864] Biomaterials. 2005 Dec;26(35):7260-75 [16023200] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708 [15951334] Annu Rev Immunol. 2006;24:99-146 [16551245] J Virol. 2006 May;80(9):4521-7 [16611912] Crit Rev Toxicol. 2006 Mar;36(3):189-217 [16686422] Nature. 2006 May 11;441(7090):235-8 [16648838] Toxicol Sci. 2006 Jul;92(1):5-22 [16484287] Toxicol Lett. 2006 Aug 1;165(1):88-100 [16527436] Immunobiology. 2006;211(6-8):511-24 [16920490] Ann Occup Hyg. 2007 Jan;51(1):1-12 [17041243] Cardiovasc Res. 2007 Feb 1;73(3):549-59 [17207782] Annu Rev Immunol. 2007;25:821-52 [17201677] Nanomedicine. 2007 Mar;3(1):95-101 [17379174] Pak J Pharm Sci. 2007 Apr;20(2):157-62 [17416573] J Biol Inorg Chem. 2007 May;12(4):527-34 [17353996] Toxicol Appl Pharmacol. 2007 Jun 15;221(3):339-48 [17482224] Nanomedicine. 2007 Jun;3(2):168-71 [17468052] Langmuir. 2007 Aug 14;23(17):8670-3 [17658863] Adv Drug Deliv Rev. 2007 Jul 10;59(6):403-10 [17573146] J Food Prot. 2007 Aug;70(8):1844-9 [17803140] Acta Biomater. 2008 Mar;4(2):273-83 [17720641] Blood. 2000 Apr 15;95(8):2484-90 [10753825] Med Mycol. 2000;38 Suppl 1:335-47 [11204162] Environ Health Perspect. 2001 May;109(5):515-21 [11401764] Exp Mol Pathol. 2002 Feb;72(1):1-9 [11784117] Free Radic Biol Med. 2002 Sep 1;33(5):676-84 [12208354] Environ Health Perspect. 2002 Nov;110(11):1105-11 [12417481] N1 - Last updated - 2017-01-18 ER - TY - BOOK T1 - Protecting Poultry Workers from Avian Influenza (Bird Flu) AN - 58792232; 2008-197923 AB - The National Institute for Occupational Safety and Health (NIOSH) requests help in protecting poultry workers from infection with viruses that cause avian influenza (also known as bird flu). Although human infection with avian influenza viruses is rare, workers infected with certain types of these viruses may become ill or die. Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), May 2008, 32 pp. AU - National Institute for Occupational Safety and Health Y1 - 2008/05// PY - 2008 DA - May 2008 EP - 32p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Agriculture and agricultural policy - Livestock, meat, and animal products industry KW - Health conditions and policy - Diseases and disorders KW - Agriculture and agricultural policy - Processed food industries KW - Environment and environmental policy - Animals KW - Social conditions and policy - Public safety and security KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Food industry KW - Safety measures KW - Birds KW - Communicable diseases KW - Avian influenza KW - Working conditions KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58792232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Institute+for+Occupational+Safety+and+Health&rft.aulast=National+Institute+for+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2008-05-01&rft.volume=&rft.issue=&rft.spage=32p&rft.isbn=&rft.btitle=Protecting+Poultry+Workers+from+Avian+Influenza+%28Bird+Flu%29&rft.title=Protecting+Poultry+Workers+from+Avian+Influenza+%28Bird+Flu%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2008-128/ LA - English DB - PAIS Index N1 - Date revised - 2008-10-03 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Protecting Poultry Workers from Exposure to Avian Influenza Viruses AN - 58771280; 2008-159128 AB - Emerging zoonotic diseases are of increasing regional and global importance. Preventing occupational exposure to zoonotic diseases protects workers as well as their families, communities, and the public health. Workers can be protected from zoonotic diseases most effectively by preventing and controlling diseases in animals, reducing workplace exposures, and educating workers. Certain avian influenza viruses are potential zoonotic disease agents that may be transmitted from infected birds to humans. Poultry workers are at risk of becoming infected with these viruses if they are exposed to infected birds or virus-contaminated materials or environments. Critical components of worker protection include educating employers and training poultry workers about occupational exposure to avian influenza viruses. Other recommendations for protecting poultry workers include the use of good hygiene and work practices, personal protective clothing and equipment, vaccination for seasonal influenza viruses, antiviral medication, and medical surveillance. Current recommendations for protecting poultry workers from exposure to avian influenza viruses are summarized in this article. Adapted from the source document. JF - Public Health Reports AU - MacMahon, Kathleen L AU - Delaney, Lisa J AU - Kullman, Greg AU - Gibbins, John D AU - Decker, John AU - Kiefer, Max J AD - Education and Information Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS-C32, 4676 Columbia Pkwy., Cincinnati, OH 45230, Tel: 513-533-8547, Fax: 513-533-8230 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 316 EP - 322 PB - Association of Schools of Public Health, Washington, DC VL - 123 IS - 3 SN - 0033-3549, 0033-3549 KW - Agriculture and agricultural policy - Livestock, meat, and animal products industry KW - Health conditions and policy - Diseases and disorders KW - Health conditions and policy - Health and health policy KW - Agriculture and agricultural policy - Processed food industries KW - Labor conditions and policy - Work and labor KW - Food industry KW - Communicable diseases KW - Avian influenza KW - Labor KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58771280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Protecting+Poultry+Workers+from+Exposure+to+Avian+Influenza+Viruses&rft.au=MacMahon%2C+Kathleen+L%3BDelaney%2C+Lisa+J%3BKullman%2C+Greg%3BGibbins%2C+John+D%3BDecker%2C+John%3BKiefer%2C+Max+J&rft.aulast=MacMahon&rft.aufirst=Kathleen&rft.date=2008-05-01&rft.volume=123&rft.issue=3&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Avian influenza; Communicable diseases; Public health; Labor; Food industry ER - TY - JOUR T1 - Active and passive smoking and depression among Japanese workers AN - 57303601; 200916176 AB - Objective To assess the relation of passive and active smoking to depressive symptoms in 1839 men and 931 women working in a suburb of Tokyo in 2002. Method Self-reported smoking history and exposure to passive smoking (no, occasional, or regular) at work and at home. Depressive symptoms according to the Center for Epidemiologic Studies Depression Scale, with a cut-off point of 16. Results Compared to never smokers unexposed to passive smoking, never smokers reporting regular and occasional exposure to passive smoking at work had increased depressive symptoms. The adjusted odds ratios (aORs) were 1.92 (95% confidence interval (CI) 1.14, 3.23) for regular exposure and 1.63 (95% CI 1.08, 2.47) for occasional exposure. Current smokers had significantly increased depressive symptoms (aOR ranging from 2.25 to 2.38) but former smokers had only marginal increases of depressive symptoms (aOR ranging from 1.43 to 1.55). Gender did not modify the effects of active/passive smoking on depressive symptoms. Conclusion Passive smoking at work and current smoking appear associated with higher levels of depressive symptoms. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Nakata, Akinori AU - Takahashi, Masaya AU - Ikeda, Tomoko AU - Hojou, Minoru AU - Nigam, Jeannie A AU - Swanson, Naomi G AD - National Institute for Occupational Safety and Health, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 451 EP - 456 PB - Elsevier Ltd, The Netherlands VL - 46 IS - 5 SN - 0091-7435, 0091-7435 KW - Passive smoking Smoking Depressive symptoms Working population Epidemiology Occupational health KW - Smoking KW - Passive smoking KW - Depression KW - Gender KW - Marginal KW - Confidence intervals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57303601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Active+and+passive+smoking+and+depression+among+Japanese+workers&rft.au=Nakata%2C+Akinori%3BTakahashi%2C+Masaya%3BIkeda%2C+Tomoko%3BHojou%2C+Minoru%3BNigam%2C+Jeannie+A%3BSwanson%2C+Naomi+G&rft.aulast=Nakata&rft.aufirst=Akinori&rft.date=2008-05-01&rft.volume=46&rft.issue=5&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2008.01.024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Depression; Passive smoking; Smoking; Gender; Marginal; Confidence intervals DO - http://dx.doi.org/10.1016/j.ypmed.2008.01.024 ER - TY - JOUR T1 - The quality of medical care for comorbid conditions of depressed elders AN - 57251326; 200823594 AB - Objectives: In light of large variation in the quality of medical care, this study assesses the extent to which medical care for depressed elders is consistent with systematic quality standards. Method: Using the Donabedian model, we assess factors related to two quality measures: medical service fit and medical provider contact. We assessed 110 depressed older adults with comorbid conditions through practical guidelines of medical services. Results: We found large variation in the quality of medical care and differences between two quality measures. Structure (Medigap insurance and clinical factors) and process factors (medical professional visits, ER visits, and adequacy of informal care) influenced the quality of medical care. Conclusion: Emphasizing accuracy in quality measures, quality disparities by medical conditions call attention to the risky population with certain conditions targeted for closer follow-up. Appropriate medical care processes can enhance the quality. Adapted from the source document. JF - Aging & Mental Health AU - Hong, Song-Iee AU - Morrow-Howell, Nancy AU - Proctor, Enola AU - Wentz, Joan D AU - Rubin, Eugene AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, Missouri Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 323 EP - 332 PB - Taylor & Francis, Abingdon UK VL - 12 IS - 3 SN - 1360-7863, 1360-7863 KW - Measurement KW - Elderly people KW - Quality of care KW - Health care KW - Medical services KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57251326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+%26+Mental+Health&rft.atitle=The+quality+of+medical+care+for+comorbid+conditions+of+depressed+elders&rft.au=Hong%2C+Song-Iee%3BMorrow-Howell%2C+Nancy%3BProctor%2C+Enola%3BWentz%2C+Joan+D%3BRubin%2C+Eugene&rft.aulast=Hong&rft.aufirst=Song-Iee&rft.date=2008-05-01&rft.volume=12&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Aging+%26+Mental+Health&rft.issn=13607863&rft_id=info:doi/10.1080%2F13607860802121118 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-12-09 N1 - Last updated - 2016-09-27 N1 - CODEN - AMHTFD N1 - SubjectsTermNotLitGenreText - Health care; Quality of care; Elderly people; Comorbidity; Medical services; Measurement DO - http://dx.doi.org/10.1080/13607860802121118 ER - TY - JOUR T1 - Reduced Bone Cortical Thickness in Boys with Autism or Autism Spectrum Disorder AN - 57244960; 200821706 AB - Bone development, casein-free diet use, supplements, and medications were assessed for 75 boys with autism or autism spectrum disorder, ages 4-8 years. Second metacarpal bone cortical thickness (BCT), measured on hand-wrist radiographs, and % deviations in BCT from reference medians were derived. BCT increased with age, but % deviations evidenced a progressive fall-off (p = .02): +3.1 - 4.7%, -6.5 - 4.0%, -16.6 - 3.4%, -19.4 - 3.7%, -24.1 - 4.4%, at ages 4-8, respectively, adjusting for height. The 12% of the boys on casein-free diets had an overall % deviation of -18.9 - 3.7%, nearly twice that of boys on minimally restricted or unrestricted diets (-10.5 - 1.3%, p < .04), although even for boys on minimally restricted or unrestricted diets the % deviation was highly significant (p < .001). Our data suggest that the bone development of autistic boys should be monitored as part of routine care, especially if they are on casein-free diets. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Hediger, Mary L AU - England, Lucinda J AU - Molloy, Cynthia A AU - Yu, Kai F AU - Manning-Courtney, Patricia AU - Mills, James L AD - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health (DESPR, NICHD, NIH), Department of Health and Human Services, Bldg 6100, Rm 7B03, MSC 7510, 9000 Rockville Pike, Bethesda, MD 20892-7510, USA hedigerm@exchange.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 848 EP - 856 PB - Springer, Dordrecht The Netherlands VL - 38 IS - 5 SN - 0162-3257, 0162-3257 KW - Bones KW - Diet KW - Autistic children KW - Child development KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57244960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Reduced+Bone+Cortical+Thickness+in+Boys+with+Autism+or+Autism+Spectrum+Disorder&rft.au=Hediger%2C+Mary+L%3BEngland%2C+Lucinda+J%3BMolloy%2C+Cynthia+A%3BYu%2C+Kai+F%3BManning-Courtney%2C+Patricia%3BMills%2C+James+L&rft.aulast=Hediger&rft.aufirst=Mary&rft.date=2008-05-01&rft.volume=38&rft.issue=5&rft.spage=848&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-007-0453-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Autistic children; Autistic spectrum disorders; Bones; Child development; Diet DO - http://dx.doi.org/10.1007/s10803-007-0453-6 ER - TY - JOUR T1 - Outcomes for Youth Residential Treatment Programs Using Administrative Data from the Child Welfare System: A Risk-Adjustment Application AN - 57233558; 200820006 AB - This study assessed whether administrative data from the public child welfare system could be used to develop risk-adjusted performance reports for residential mental health programs for adolescents. Regression methods were used with 3,759 residential treatment spells for 2,784 children and youth to determine which outcomes could be adequately risk adjusted for case mix. Expected outcomes were created for each residential program given its case mix; then, expected and achieved outcomes were compared. For most programs, achieved results did not differ significantly from expected results for individual outcomes. Overall, outcomes achieved were not impressive. Only one quarter of spells resulted in a youth being maintained in a single less restrictive setting in the year following discharge. Methodological implications of this study suggest further refinements are needed for child welfare administrative data in order to develop risk-adjusted report cards of program performance. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - McMillen, J Curtis AU - Lee, Bethany R AU - Jonson-Reid, Melissa AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, Campus Box 1196, St. Louis, MO 63130, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 189 EP - 197 PB - Springer, Dordrecht The Netherlands VL - 35 IS - 3 SN - 0894-587X, 0894-587X KW - Residential treatment KW - Mental health services KW - Risk adjustment KW - Child protection KW - Young people KW - Child welfare KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57233558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Outcomes+for+Youth+Residential+Treatment+Programs+Using+Administrative+Data+from+the+Child+Welfare+System%3A+A+Risk-Adjustment+Application&rft.au=McMillen%2C+J+Curtis%3BLee%2C+Bethany+R%3BJonson-Reid%2C+Melissa&rft.aulast=McMillen&rft.aufirst=J&rft.date=2008-05-01&rft.volume=35&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-007-0155-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Young people; Risk adjustment; Child protection; Residential treatment; Mental health services; Child welfare DO - http://dx.doi.org/10.1007/s10488-007-0155-6 ER - TY - JOUR T1 - Does participation in the food stamp program increase the prevalence of obesity and health care spending? AN - 37030536; 3804128 AB - We use panel data techniques and information on state-level Food Stamp Program characteristics to obtain unbiased estimates of the impact of Food Stamp Program participation on weight status and health care spending among nonelderly adults. Our results suggest that program participation by women leads to a 5.9% (p = 0.07) increase in their likelihood of overweight and obesity, which is smaller than previous estimates, and to higher medical expenditures. The direct effect of program participation on medical spending through higher discretionary income is significantly larger than the indirect effect through changes in weight status. Reprinted by permission of the American Agricultural Economics Association JF - American journal of agricultural economics AU - Meyerhoefer, Chad D AU - Pylypchuk, Yuriy AD - US Agency for Healthcare Research and Quality Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 287 EP - 305 VL - 90 IS - 2 SN - 0002-9092, 0002-9092 KW - Economics KW - Food stamps KW - Obesity KW - Health expenditure KW - Food KW - Government programmes KW - Social security KW - U.S.A. KW - Panel data KW - Poverty alleviation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37030536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+agricultural+economics&rft.atitle=Does+participation+in+the+food+stamp+program+increase+the+prevalence+of+obesity+and+health+care+spending%3F&rft.au=Meyerhoefer%2C+Chad+D%3BPylypchuk%2C+Yuriy&rft.aulast=Meyerhoefer&rft.aufirst=Chad&rft.date=2008-05-01&rft.volume=90&rft.issue=2&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=American+journal+of+agricultural+economics&rft.issn=00029092&rft_id=info:doi/10.1111%2Fj.1467-8276.2007.01125.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11923 11949 13521; 9963 9962; 5576 5574 10472; 5114; 8823; 5780 4618; 9144 8160 8163; 433 293 14 DO - http://dx.doi.org/10.1111/j.1467-8276.2007.01125.x ER - TY - RPRT T1 - FOREWORD AN - 236448189 AB - NLEHS/NIH, the National Institute for Occupational Safety and Health of the Centers for Disease Control and Prevention (NIOSH/CDC), and the National Center for Toxicological Research of the Food and Drug Administration (NCTR/FDA) Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236448189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-05-01&rft.volume=&rft.issue=540&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program May 2008 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYLENE BLUE TRIHYDRATE (CAS NO. 7220-79-3) IN F344/N RATS AND B6C3F^sub 1^ MICE (GAVAGE STUDIES) AN - 236441104; 18685714 AB - Methylene blue trihydrate has a variety of medical uses, including the treatment of methemoglobinemia and psychiatric disorders and as a disinfectant and biological stain. We studied the effects of methylene blue trihydrate on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing methylene blue trihydrate in aqueous methylcellulose directly into the stomachs of male and female rats and mice. Groups of 50 male and female rats received 5, 25, or 50 milligrams of methylene blue trihydrate per kilogram body weight five days per week for two years; groups of 50 male and female mice received 2.5, 12.5, or 25 milligrams of methylene blue per kilogram of body weight for the same duration. Groups of animals receiving methylcellulose alone served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. The two highest dose groups of male and female rats weighed less than the control animals, while the two highest dose groups of female mice weighed more than their corresponding control group. In male and female rats and mice, the blood of the animals was affected, with animals receiving the highest doses experiencing methemoglobinemia and anemia. This caused secondary injury to the spleen in these animals. Cancer of the pancreatic islets was increased in male rats receiving methylene blue trihydrate, and some uncommon tumors of the small intestine were seen in exposed male mice. There was a slight increase in malignant lymphomas in exposed male and female mice. We conclude that exposure to methylene blue caused pancreatic islet tumors in male rats and small intestine tumors in male mice. Malignant lymphomas in male and female mice were possibly associated with methylene blue trihydrate exposure. Methylene blue trihydrate caused blood abnormalities and anemia in male and female rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1 EP - 224 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Enzyme Inhibitors KW - Mutagens KW - Methylene Blue KW - Rodents KW - Toxicology KW - Carcinogens KW - Anemia KW - Lymphomas KW - Animals KW - DNA Damage KW - Anemia -- chemically induced KW - Islets of Langerhans -- drug effects KW - Lymphoma -- chemically induced KW - Methemoglobinemia -- pathology KW - Anemia -- pathology KW - Neoplasms, Experimental -- pathology KW - Islets of Langerhans -- pathology KW - Rats KW - Chromosome Aberrations -- chemically induced KW - Rats, Inbred F344 KW - Intestinal Neoplasms -- chemically induced KW - CHO Cells KW - Intestine, Small -- drug effects KW - Methemoglobinemia -- chemically induced KW - Male KW - Administration, Oral KW - Intestinal Neoplasms -- pathology KW - Cricetulus KW - Pancreatic Neoplasms -- chemically induced KW - Mice KW - Mice, Inbred Strains KW - Pancreatic Neoplasms -- pathology KW - Sister Chromatid Exchange -- drug effects KW - Body Weight -- drug effects KW - Intestine, Small -- pathology KW - Lymphoma -- pathology KW - Female KW - Cricetinae KW - Neoplasms, Experimental -- etiology KW - Enzyme Inhibitors -- toxicity KW - Toxicity Tests KW - Mutagens -- toxicity KW - Methylene Blue -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236441104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+METHYLENE+BLUE+TRIHYDRATE+%28CAS+NO.+7220-79-3%29+IN+F344%2FN+RATS+AND+B6C3F%5Esub+1%5E+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-05-01&rft.volume=&rft.issue=540&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program May 2008 N1 - Document feature - Tables; Diagrams; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 236440598 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236440598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-05-01&rft.volume=&rft.issue=540&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program May 2008 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Enzyme-Linked Immunosorbent Assays Using Novel Japanese Encephalitis Virus Antigen Improve the Accuracy of Clinical Diagnosis of Flavivirus Infections AN - 21498045; 12494269 AB - The cross-reactive antibodies induced by flavivirus infections confound serodiagnosis and pathogenesis, especially in secondary infections caused by antigenically closely related yet distinct flaviviruses. The envelope (E) glycoprotein fusion peptide contains immunodominant cross-reactive determinants. Using a recombinant Japanese encephalitis virus (JEV) premembrane and E expression plasmid producing JEV virus-like particles (VLPs), dramatic reductions in cross-reactivity were produced by the G106K-L107D (KD) double-mutant VLP against a panel of flavivirus murine monoclonal antibodies. Human serum panels from patients with recent flavivirus infections were analyzed to compare the accuracy of JEV wild-type (WT) and KD VLPs as serodiagnostic antigens in enzyme-linked immunosorbent assays. Statistical analysis demonstrated significant differences in assay performances for accurate determination of current JEV infections between WT and KD antigens by detecting immunoglobulin M antibodies at a serum dilution of 1:4,000 (likelihood ratios = 2.74 [WT] and 22 [KD]). The application and continued development of cross-reactivity-reduced antigens should improve both flavivirus infection serodiagnosis and estimates of disease burden. JF - Clinical and Vaccine Immunology AU - Chiou, Shyan-Song AU - Crill, Wayne D AU - Chen, Li-Kuang AU - Chang, Gwong-Jen J AD - Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado, gxc7@cdc.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 825 EP - 835 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 15 IS - 5 SN - 1556-679X, 1556-679X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - Cross-reactivity KW - Virus-like particles KW - Monoclonal antibodies KW - Statistical analysis KW - Secondary infection KW - Plasmids KW - Flavivirus KW - Encephalitis KW - Envelopes KW - Japanese encephalitis virus KW - Glycoproteins KW - Immunoglobulin M KW - F 06905:Vaccines KW - V 22300:Methods KW - W 30915:Pharmaceuticals & Vaccines KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21498045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Enzyme-Linked+Immunosorbent+Assays+Using+Novel+Japanese+Encephalitis+Virus+Antigen+Improve+the+Accuracy+of+Clinical+Diagnosis+of+Flavivirus+Infections&rft.au=Chiou%2C+Shyan-Song%3BCrill%2C+Wayne+D%3BChen%2C+Li-Kuang%3BChang%2C+Gwong-Jen+J&rft.aulast=Chiou&rft.aufirst=Shyan-Song&rft.date=2008-05-01&rft.volume=15&rft.issue=5&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00004-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Envelopes; Virus-like particles; Cross-reactivity; Monoclonal antibodies; Statistical analysis; Glycoproteins; Secondary infection; Plasmids; Immunoglobulin M; Encephalitis; Japanese encephalitis virus; Flavivirus DO - http://dx.doi.org/10.1128/CVI.00004-08 ER - TY - JOUR T1 - Biomedical Ultrasound/Bioresponse to Vibration: Ultrasonic Characterization of Bone III AN - 21265478; 10960130 JF - Journal of the Acoustical Society of America AU - Wear, KA AU - Bossy, E AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Ave, Bldg 62, Rm 3108, Silver Spring, MD 20993, USA Y1 - 2008/05// PY - 2008 DA - May 2008 VL - 123 IS - 5 SN - 0001-4966, 0001-4966 KW - Biotechnology and Bioengineering Abstracts KW - Bone KW - Vibrations KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21265478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Biomedical+Ultrasound%2FBioresponse+to+Vibration%3A+Ultrasonic+Characterization+of+Bone+III&rft.au=Wear%2C+KA%3BBossy%2C+E&rft.aulast=Wear&rft.aufirst=KA&rft.date=2008-05-01&rft.volume=123&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Vibrations; Bone; Ultrasound ER - TY - JOUR T1 - Factors Influencing the Growth of Salmonella during Sprouting of Naturally Contaminated Alfalfa Seeds AN - 21056612; 8196932 AB - In this study, the factors that affect Salmonella growth during sprouting of naturally contaminated alfalfa seeds associated with two previous outbreaks of salmonellosis were examined. A minidrum sprouter equipped with automatic irrigation and rotation systems was built to allow sprouting to be conducted under conditions similar to those used commercially. The growth of Salmonella during sprouting in the minidrum was compared with that observed in sprouts grown in glass jars under conditions commonly used at home. The level of Salmonella increased by as much as 4 log units after 48 h of sprouting in jars but remained constant during the entire sprouting period in the minidrum. The effect of temperature and irrigation frequency on Salmonella growth was examined. Increasing the sprouting temperature from 20 to 30C increased the Salmonella counts by as much as 2 log units on sprouts grown both in the minidrum and in the glass jars. Decreasing the irrigation frequency from every 20 min to every 2 h during sprouting in the minidrum or from every 4 h to every 24 h during sprouting in the glass jars resulted in an approximately 2-log increase in Salmonella counts. The levels of total aerobic mesophilic bacteria, coliforms, and Salmonella in spent irrigation water closely reflected those found in sprouts, confirming that monitoring of spent irrigation water is a good way to monitor pathogen levels during sprouting. JF - Journal of Food Protection AU - Fu, Tong-Jen AU - Reineke, Karl F AU - Chirtel, Stuart AU - Vanpelt, Olif M AD - U.S. Food and Drug Administration Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 888 EP - 896 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 71 IS - 5 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - Temperature effects KW - Mesophilic bacteria KW - Seeds KW - Coliforms KW - Irrigation KW - Temperature KW - alfalfa KW - outbreaks KW - Pathogens KW - Food contamination KW - irrigation water KW - Growth KW - Salmonellosis KW - Salmonella KW - A 01330:Food Microbiology KW - J 02400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21056612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Factors+Influencing+the+Growth+of+Salmonella+during+Sprouting+of+Naturally+Contaminated+Alfalfa+Seeds&rft.au=Fu%2C+Tong-Jen%3BReineke%2C+Karl+F%3BChirtel%2C+Stuart%3BVanpelt%2C+Olif+M&rft.aulast=Fu&rft.aufirst=Tong-Jen&rft.date=2008-05-01&rft.volume=71&rft.issue=5&rft.spage=888&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282008%29071%253C0888%3AFITGOD%253E2.3.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Mesophilic bacteria; Coliforms; Seeds; Salmonellosis; Irrigation; Pathogens; Growth; Temperature; alfalfa; outbreaks; Food contamination; irrigation water; Salmonella DO - http://dx.doi.org/10.1043/0362-028X(2008)071%3C0888:FITGOD%3E2.3.CO;2 ER - TY - JOUR T1 - Underimmunization of American Indian and Alaska Native Children AN - 20972430; 8202783 AB - OBJECTIVE. The goal was to determine whether disparities in childhood immunization coverage exist between American Indian/Alaska Native children and non-Hispanic white children. METHODS. We compared immunization coverage with the 4 diphtheria-tetanus-pertussis, 3 poliovirus, 1 measles-mumps-rubella, 3 Haemophilus influenza type b, and 3 hepatitis B(4:3:1:3:3) series and its individual vaccine components ( greater than or equal to 4 doses of diphtheria, tetanus, and pertussis vaccine; greater than or equal to 3 doses of oral or inactivated polio vaccine; greater than or equal to 1 dose of measles, mumps, and rubella vaccine; greater than or equal to 3 doses of Haemophilus influenzae type b vaccine; and greater than or equal to 3 doses of hepatitis B vaccine) between American Indian/Alaska Native children and non-Hispanic white children from 2000 to 2005, using data from the National Immunization Survey. RESULTS. Although immunization coverage increased for both populations from 2001 to 2004, American Indian/Alaska Native children had significantly lower immunization coverage, compared with non-Hispanic white children, over that time period. In 2005, coverage continued to increase for American Indian/Alaska Native children but decreased for non-Hispanic white children, and no statistically significant disparity in 4:3:1:3:3 coverage was evident in that year. CONCLUSIONS. Disparities in immunization coverage for American Indian/Alaska Native children have been present, but unrecognized, since 2001. The absence of a disparity in coverage in 2005 is encouraging but is tempered by the fact that coverage for non-Hispanic white children decreased in that year. JF - Pediatrics AU - Groom, Amy V AU - Washington, Michael L AU - Smith, Philip J AU - Bryan, Ralph T AD - Immunization Services Division, National Center for Immunization and Respiratory Diseases. Office of Minority Health and Health Disparities, Office of Strategy and Innovation, Office of the Director, Centers for Disease Control and Prevention, Atlanta, Georgia. Division of Epidemiology and Disease Prevention, Office of Public Health Support, Indian Health Service, Albuquerque, New Mexico Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 938 EP - 944 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - 5 SN - 0031-4005, 0031-4005 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Pertussis KW - Haemophilus influenzae KW - Data processing KW - Measles KW - Statistical analysis KW - Poliovirus 1 KW - Diphtheria KW - Tetanus KW - Children KW - Rubella KW - Immunization KW - Influenza KW - Hepatitis B KW - Vaccines KW - Mumps KW - J 02400:Human Diseases KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20972430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Underimmunization+of+American+Indian+and+Alaska+Native+Children&rft.au=Groom%2C+Amy+V%3BWashington%2C+Michael+L%3BSmith%2C+Philip+J%3BBryan%2C+Ralph+T&rft.aulast=Groom&rft.aufirst=Amy&rft.date=2008-05-01&rft.volume=121&rft.issue=5&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pertussis; Data processing; Measles; Statistical analysis; Diphtheria; Children; Tetanus; Rubella; Immunization; Influenza; Hepatitis B; Vaccines; Mumps; Haemophilus influenzae; Poliovirus 1 ER - TY - JOUR T1 - Effect of Aloe vera whole leaf extract on short chain fatty acids production by Bacteroides fragilis, Bifidobacterium infantis and Eubacterium limosum AN - 20962385; 8225920 AB - Aims:To investigate the effect of Aloe vera whole leaf extract on pure and mixed human gut bacterial cultures by assessing the bacterial growth and changes in the production of short chain fatty acids. Methods and Results:Bacteroides fragilis, Bifidobacterium infantis, and Eubacterium limosum were incubated with Aloe vera extracts [0%, 0.5%, 1%, 1.5% and 2%; (w-v)] for 24 and 48h. Short chain fatty acids production was measured by gas chromatography-mass spectrometry analyses. A significant linear increase in growth response to Aloe vera supplementation was observed at 24h for each of the bacterial cultures; however, only B. infantis and a mixed bacterial culture showed a significant positive linear dose response in growth at 48h. In pure bacteria cultures, a significantly enhanced dose response to Aloe vera supplementation was observed in the production of acetic acid by B. infantis at 24h and of butyric acid by E. limosum at 24 and 48h. In the mixed bacterial culture, the production of propionic acid was reduced significantly at 24 and 48h in a dose-dependent fashion, whereas butyric acid production showed a significant linear increase. Conclusions:The results indicated that Aloe vera possessed bacteriogenic activity in vitro and altered the production of acetic, butyric and propionic acids by micro-organisms selected for the study. Significance and Impact of the Study:The results of the study suggest that consumption of a dietary supplement, Aloe vera, may alter the production of short chain fatty acids by human intestinal microflora. JF - Letters in Applied Microbiology AU - Pogribna, M AU - Freeman, J P AU - Paine, D AU - Boudreau, MD AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA, mary.boudreau@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 575 EP - 580 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 46 IS - 5 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Aloe vera KW - bacteria KW - intestine KW - short chain fatty acids KW - Bacteroides fragilis KW - Propionic acid KW - Leaves KW - Acetic acid KW - Mass spectroscopy KW - Intestinal microflora KW - Aloe vera KW - Bifidobacterium infantis KW - Digestive tract KW - Gas chromatography KW - Dietary supplements KW - Fatty acids KW - Eubacterium limosum KW - Butyric acid KW - J 02330:Biochemistry KW - A 01310:Products of Microorganisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20962385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Letters+in+Applied+Microbiology&rft.atitle=Effect+of+Aloe+vera+whole+leaf+extract+on+short+chain+fatty+acids+production+by+Bacteroides+fragilis%2C+Bifidobacterium+infantis+and+Eubacterium+limosum&rft.au=Pogribna%2C+M%3BFreeman%2C+J+P%3BPaine%2C+D%3BBoudreau%2C+MD&rft.aulast=Pogribna&rft.aufirst=M&rft.date=2008-05-01&rft.volume=46&rft.issue=5&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Letters+in+Applied+Microbiology&rft.issn=1472-765X&rft_id=info:doi/10.1111%2Fj.1472-765X.2008.02346.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Intestinal microflora; Digestive tract; Gas chromatography; Dietary supplements; Leaves; Propionic acid; Fatty acids; Acetic acid; Mass spectroscopy; Butyric acid; Bacteroides fragilis; Aloe vera; Bifidobacterium infantis; Eubacterium limosum DO - http://dx.doi.org/10.1111/j.1472-765X.2008.02346.x ER - TY - JOUR T1 - Modeling the inactivation kinetics of bacillus spores by glutaraldehyde AN - 20943687; 8225932 AB - Aims:Our goal was to develop a mathematical kinetic model to predict the sporicidal activity of glutaraldehyde, which is an active ingredient frequently used in commercial products employed for liquid disinfection and decontamination. Methods and Results:We used our previously published data on spore inactivation by glutaraldehyde to develop a predictive model obtained by calculating multiple independent modifying functions. The model was then validated by comparing model predicted values to new experimental data. For model validation, quality-controlled spores of Bacillus athrophaeus (previously and generally known as Bacillus subtilis globigii) were exposed under conditions where several physicochemical variables were modified simultaneously, and the spore surviving fractions were measured by titration. Conclusions:The model predicted within one order of magnitude variations in sporicidal effectiveness due to changes in main parameters (glutaraldehyde concentration, temperature or time-duration of the treatment). Other parameters such pH, salinity and the effect of serum concentration were also addressed, albeit with less accuracy. Significance and Impact of the study:The model should be useful to quantitatively estimate the effectiveness of glutaraldehyde-based disinfectants, decontaminants, and germicides under the described conditions, particularly when limited data are available or when spore virulence (like that of Bacillus anthracis) precludes extensive experimentation. A similar approach could predict the effectiveness of a variety of decontaminant and disinfecting agents. JF - Letters in Applied Microbiology AU - Retta, S M AU - Sagripanti, J-L AD - Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA, joseluis.sagripanti@us.army.mil Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 568 EP - 574 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 46 IS - 5 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacillus KW - decontamination KW - disinfection KW - glutaraldehyde KW - spore KW - Temperature effects KW - Disinfection KW - Bacillus subtilis KW - Mathematical models KW - Decontamination KW - Bacillus anthracis KW - Models KW - Virulence KW - Disinfectants KW - Salinity effects KW - Kinetics KW - Titration KW - Germicides KW - Glutaraldehyde KW - Spores KW - pH effects KW - A 01490:Miscellaneous KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20943687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Letters+in+Applied+Microbiology&rft.atitle=Modeling+the+inactivation+kinetics+of+bacillus+spores+by+glutaraldehyde&rft.au=Retta%2C+S+M%3BSagripanti%2C+J-L&rft.aulast=Retta&rft.aufirst=S&rft.date=2008-05-01&rft.volume=46&rft.issue=5&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Letters+in+Applied+Microbiology&rft.issn=1472-765X&rft_id=info:doi/10.1111%2Fj.1472-765X.2008.02358.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Disinfection; Mathematical models; Decontamination; Models; Virulence; Disinfectants; Kinetics; Salinity effects; Titration; Germicides; Spores; Glutaraldehyde; pH effects; Bacillus subtilis; Bacillus anthracis DO - http://dx.doi.org/10.1111/j.1472-765X.2008.02358.x ER - TY - JOUR T1 - Neural Network-Based Evaluation of Chronic Non-Thermal Effects of Modulated 2450 MHz Microwave Radiation on Electroencephalogram AN - 208948454; 18259868 AB - The effects of chronic exposure (2 h daily for 21 days) of 1 kHz square wave-modulated 2450 MHz microwave radiation (non-thermal) on sleep-EEG, open field behavior, and thyroid hormones (T3, T4, and TSH) have been analyzed in an animal model. Results revealed significant changes in these pathophysiological parameters (p < 0.05 or better), except body temperature, grooming behavior, and TSH levels. The sleep-EEG power spectrum data for slow wave sleep (SWS), rapid eye movement (REM) sleep, and awake (AWA) states in two experimental groups of rats (microwave exposed and the control) were tested by an artificial neural network (ANN), containing 60 nodes in input layer, weighted from power spectrum data from 0 to 30 Hz, 18 nodes in hidden layer and an output node. The target output values for this network were determined with another five-layered neural network (with the structure of 6-14-1-14-6). The input and output of this network was assigned with the six confirmed pathophysiological changes. The most important feature for chronic exposure of 2450 MHz microwave exposure and for control subjects was extracted from the third layer single neuron and used as the target value for the three-layered ANN. The network was found effective in recognizing the EEG power spectra with an average of 71.93% for microwave exposure and 93.13% for control subjects, respectively. However, the lower percentage of pattern identification agreement in the microwave-exposed group in comparison to the control group suggest only mild effects of microwave exposure with this experimental setup. JF - Annals of Biomedical Engineering AU - Sinha, Rakesh Kumar AU - Aggarwal, Yogender AU - Upadhyay, Prabhat Kumar AU - Dwivedi, Anjana AU - Keshri, Anup Kumar AU - Das, Barda Nand Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 839 EP - 51 CY - New York PB - Springer Science & Business Media VL - 36 IS - 5 SN - 00906964 KW - Medical Sciences KW - Rats KW - Radiation Dosage KW - Hot Temperature KW - Animals KW - Diagnosis, Computer-Assisted -- methods KW - Computer Simulation KW - Models, Neurological KW - Dose-Response Relationship, Radiation KW - Electroencephalography -- methods KW - Male KW - Sleep -- physiology KW - Sleep -- radiation effects KW - Microwaves KW - Neural Networks (Computer) KW - Brain -- radiation effects KW - Brain -- physiology KW - Electroencephalography -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/208948454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=Neural+Network-Based+Evaluation+of+Chronic+Non-Thermal+Effects+of+Modulated+2450+MHz+Microwave+Radiation+on+Electroencephalogram&rft.au=Sinha%2C+Rakesh+Kumar%3BAggarwal%2C+Yogender%3BUpadhyay%2C+Prabhat+Kumar%3BDwivedi%2C+Anjana%3BKeshri%2C+Anup+Kumar%3BDas%2C+Barda+Nand&rft.aulast=Sinha&rft.aufirst=Rakesh&rft.date=2008-05-01&rft.volume=36&rft.issue=5&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1007%2Fs10439-008-9450-y LA - English DB - ProQuest Central N1 - Copyright - Biomedical Engineering Society 2008 N1 - Last updated - 2014-08-30 DO - http://dx.doi.org/10.1007/s10439-008-9450-y ER - TY - JOUR T1 - Macrophage Proinflammatory Response to Francisella tularensis Live Vaccine Strain Requires Coordination of Multiple Signaling Pathways AN - 20894124; 8200913 AB - The macrophage proinflammatory response to Francisella tularensis (Ft) live vaccine strain (LVS) was shown previously to be TLR2 dependent. The observation that intracellular Ft LVS colocalizes with TLR2 and MyD88 inside macrophages suggested that Ft LVS might signal from within the phagosome. Macrophages infected with LVS Delta iglC, a Ft LVS mutant that fails to escape from the phagosome, displayed greatly increased expression of a subset of TLR2-dependent, proinflammatory genes (e.g., Tnf) but decreased expression of others (e.g., Ifnb1). This latter subset was similarly mitigated in IFN- beta super(-/-) macrophages indicating that while Ft LVS-induced TLR2 signaling is necessary, cytosolic sensing of Ft to induce IFN- beta is required for full induction of the macrophage proinflammatory response. Although LVS Delta iglC greatly increased IL-1 beta mRNA in wild-type macrophages, protein secretion was not observed. IL-1 beta secretion was also diminished in Ft LVS-infected IFN- beta super(-/-) macrophages. rIFN- beta failed to restore IL-1 beta secretion in LVS Delta iglC-infected macrophages, suggesting that signals in addition to IFN- beta are required for assembly of the inflammasome and activation of caspase-1. IFN- beta plays a central role in controlling the macrophage bacterial burden: bacterial recovery was greater in IFN- beta super(-/-) than in wild-type macrophages and treatment of Ft LVS-infected macrophages with rIFN- beta or 5,6-dimethylxanthenone-4-acetic acid, a potent IFN- beta inducer, greatly decreased the intracellular Ft LVS burden. In toto, these observations support the hypothesis that the host inflammatory response to Ft LVS is complex and requires engagement of multiple signaling pathways downstream of TLR2 including production of IFN- beta via an unknown cytosolic sensor and activation of the inflammasome. JF - Journal of Immunology AU - Cole, Leah E AU - Santiago, Araceli AU - Barry, Eileen AU - Kang, Tae Jin AU - Shirey, Kari Ann AU - Roberts, Zachary J AU - Elkins, Karen L AU - Cross, Alan S AU - Vogel, Stefanie N AD - Department of Microbiology and Immunology and. Center for Vaccine Development, School of Medicine, University of Maryland, Baltimore, MD 21201. Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Allergenic, and Parasitic Products, Center for Biologics Evaluation and Research/Food and Drug Administration, Bethesda, MD 20852 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 6885 EP - 6891 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 10 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - beta -Interferon KW - Macrophages KW - MyD88 protein KW - Tumor necrosis factor KW - Phagosomes KW - Interleukin 1 KW - TLR2 protein KW - Francisella tularensis KW - Cell activation KW - mRNA KW - Inflammation KW - Caspase-1 KW - Vaccines KW - Toll-like receptors KW - Signal transduction KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20894124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Macrophage+Proinflammatory+Response+to+Francisella+tularensis+Live+Vaccine+Strain+Requires+Coordination+of+Multiple+Signaling+Pathways&rft.au=Cole%2C+Leah+E%3BSantiago%2C+Araceli%3BBarry%2C+Eileen%3BKang%2C+Tae+Jin%3BShirey%2C+Kari+Ann%3BRoberts%2C+Zachary+J%3BElkins%2C+Karen+L%3BCross%2C+Alan+S%3BVogel%2C+Stefanie+N&rft.aulast=Cole&rft.aufirst=Leah&rft.date=2008-05-01&rft.volume=180&rft.issue=10&rft.spage=6885&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; beta -Interferon; MyD88 protein; Tumor necrosis factor; TLR2 protein; Interleukin 1; Phagosomes; Inflammation; mRNA; Cell activation; Caspase-1; Vaccines; Toll-like receptors; Signal transduction; Francisella tularensis ER - TY - JOUR T1 - Interaction of Systemically Delivered Adenovirus Vectors with Kupffer Cells in Mouse Liver AN - 20852403; 8307009 AB - When adenovirus (Ad) vectors are injected intravenously they are rapidly taken up by Kupffer cells (KCs) in the liver. This results in massive KC necrosis within minutes, followed by a more gradual disappearance of KCs from the liver. It is not known how KCs recognize Ad, or why Ad kills KCs. We used a variety of mutated and fiber-pseudotyped Ad vectors to evaluate how capsid proteins influence Ad uptake by KCs and to define the viral proteins that are involved in the destruction of KCs. We found that depletion of KCs from the liver was partially dependent on interactions between Ad and integrins, but was independent of the cox-sackievirus and Ad receptor. The Ad5 fiber shaft was proven to be a particularly important contributory factor, because vectors with the shorter Ad35 shaft were not as effective at depleting KCs. In contrast, the fiber head played no discernible role. Variations in the ability of Ad vectors to deplete KCs could not be explained by differences in the amount of Ad that reached KCs, because all mutant Ads were accumulated by KCs at similar levels. Interestingly, we found that the Ad mutant ts1 did not cause KC death; this virus is known to bind and enter cells normally, but the capsid is unable to disassemble or lyse membranes. We conclude that Ad vectors kill KCs at a postbinding step and that this cell death can be mitigated if downstream events in viral entry are blocked. JF - Human Gene Therapy AU - Smith, J S AU - Xu, Z AU - Tian, J AU - Stevenson, S C AU - Byrnes, A P AD - Division of Cellular and Gene Therapies, Food and Drug Administration, CBER, Building 29B, Room 2E20, HFM-725, Bethesda, MD 20892, USA, Andrew.Byrnes@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 547 EP - 554 VL - 19 IS - 5 SN - 1043-0342, 1043-0342 KW - Immunology Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Capsids KW - Head KW - Gene therapy KW - Hepatocytes KW - Adenovirus KW - Expression vectors KW - Fibers KW - Kupffer cells KW - Cell death KW - Necrosis KW - Integrins KW - Liver KW - Capsid protein KW - W 30905:Medical Applications KW - V 22320:Replication KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20852403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Interaction+of+Systemically+Delivered+Adenovirus+Vectors+with+Kupffer+Cells+in+Mouse+Liver&rft.au=Smith%2C+J+S%3BXu%2C+Z%3BTian%2C+J%3BStevenson%2C+S+C%3BByrnes%2C+A+P&rft.aulast=Smith&rft.aufirst=J&rft.date=2008-05-01&rft.volume=19&rft.issue=5&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2008.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Capsids; Expression vectors; Kupffer cells; Fibers; Necrosis; Cell death; Gene therapy; Head; Integrins; Hepatocytes; Liver; Capsid protein; Adenovirus DO - http://dx.doi.org/10.1089/hum.2008.004 ER - TY - JOUR T1 - Vaccine-Elicited 10-Kilodalton Culture Filtrate Protein-Specific CD8 super(+) T Cells Are Sufficient To Mediate Protection against Mycobacterium tuberculosis Infection AN - 20846411; 8198749 AB - The 10-kDa culture filtrate protein (CFP-10) and 6-kDa early secretory antigen of T cells (ESAT-6) are secreted in abundance by Mycobacterium tuberculosis and are frequently recognized by T cells from infected people. The genes encoding these proteins have been deleted from the genome of the vaccine strain Mycobacterium bovis bacillus Calmette-Guerin (BCG), and it is hypothesized that these proteins are important targets of protective immunity. Indeed, vaccination with ESAT-6 elicits protective CD4 super(+) T cells in C57BL/6 mice. We have previously shown that M. tuberculosis infection of C3H mice elicits CFP-10-specific CD8 super(+) and CD4 super(+) T cells. Here we demonstrate that immunization with a CFP-10 DNA vaccine stimulates a specific T-cell response only to the H-2K super(k)-restricted epitope CFP-10 sub(32-39). These CFP-10 sub(32-39)-specific CD8 super(+) cells undergo a rapid expansion and accumulate in the lung following challenge of immunized mice with aerosolized M. tuberculosis. Protective immunity is induced by CFP-10 DNA vaccination as measured by a CFU reduction in the lung and spleen 4 and 8 weeks after challenge with M. tuberculosis. These data demonstrate that CFP-10 is a protective antigen and that CFP-10 sub(32-39)-specific CD8 super(+) T cells elicited by vaccination are sufficient to mediate protection against tuberculosis. JF - Infection and Immunity AU - Wu, Ying AU - Woodworth, Joshua S AU - Shin, Daniel S AU - Morris, Sheldon AU - Behar, Samuel M AD - Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115. Laboratory of Mycobacterial Diseases and Cellular Immunology, FDA/CBER, Bethesda, Maryland 20892 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2249 EP - 2255 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 5 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Data processing KW - protective antigen KW - Spleen KW - Cell culture KW - Mycobacterium bovis KW - CD8 antigen KW - Infection KW - CD4 antigen KW - DNA vaccines KW - BCG KW - Lung KW - Colony-forming cells KW - Lymphocytes T KW - Tuberculosis KW - Histocompatibility antigen H-2 KW - ESAT-6 antigen KW - Epitopes KW - Mycobacterium tuberculosis KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20846411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Vaccine-Elicited+10-Kilodalton+Culture+Filtrate+Protein-Specific+CD8+super%28%2B%29+T+Cells+Are+Sufficient+To+Mediate+Protection+against+Mycobacterium+tuberculosis+Infection&rft.au=Wu%2C+Ying%3BWoodworth%2C+Joshua+S%3BShin%2C+Daniel+S%3BMorris%2C+Sheldon%3BBehar%2C+Samuel+M&rft.aulast=Wu&rft.aufirst=Ying&rft.date=2008-05-01&rft.volume=76&rft.issue=5&rft.spage=2249&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; protective antigen; Spleen; Cell culture; CD8 antigen; Infection; CD4 antigen; DNA vaccines; Lung; BCG; Colony-forming cells; Lymphocytes T; Tuberculosis; Histocompatibility antigen H-2; ESAT-6 antigen; Epitopes; Mycobacterium bovis; Mycobacterium tuberculosis ER - TY - JOUR T1 - Temperature measurements and determination of cavitation thresholds during High Intensity Focused Ultrasound (HIFU) Exposures in ex-vivo porcine muscle AN - 20823238; 10957044 AB - Cavitation in HIFU procedures can yield unpredictable results, particularly when the same location is targeted for more than several seconds. To study this effect, temperature rise was measured in fresh ex-vivo porcine tissue during HIFU exposures. Immediately following euthanasia, a section of back muscle (latissimus dorsi) was resected and a 50 mu m diameter fine bare wire thermocouple was placed via needle through the tissue. 825 kHz HIFU was then applied to the tissue focused at the thermocouple junction. Thirty second HIFU exposures of increasing pressure from 1-7.5 MPa were applied and the temperature rise and decay during and after sonication were recorded. B-mode imaging was used to monitor any cavitation activity during sonication. If cavitation was noted during the sonication, the sonication was repeated at the same pressure level two more times at 20 minute intervals in order to characterize the repeatability given that cavitation has occurred. The cavitation threshold of porcine muscle was determined to be between 4 and 7 MPa. Temperature traces obtained at various pressure levels demonstrated a wide range of heating profiles in fresh ex-vivo tissue due to both the occurrence of cavitation and viscous heating artifacts. JF - Journal of the Acoustical Society of America AU - Maruvada, S AU - Liu, Y AU - Herman, BA AU - Pritchard, W F AU - Harris, G R AD - U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA, subha.maruvada@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 VL - 123 IS - 5 SN - 0001-4966, 0001-4966 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Cavitation KW - Muscles KW - Pressure KW - imaging KW - Ultrasound KW - Sonication KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20823238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Temperature+measurements+and+determination+of+cavitation+thresholds+during+High+Intensity+Focused+Ultrasound+%28HIFU%29+Exposures+in+ex-vivo+porcine+muscle&rft.au=Maruvada%2C+S%3BLiu%2C+Y%3BHerman%2C+BA%3BPritchard%2C+W+F%3BHarris%2C+G+R&rft.aulast=Maruvada&rft.aufirst=S&rft.date=2008-05-01&rft.volume=123&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; Cavitation; Muscles; Pressure; Ultrasound; imaging; Sonication ER - TY - JOUR T1 - Recent developments in modeling and measuring scattering from trabecular bone AN - 20813182; 10959092 AB - Laboratories at the US Food and Drug Administration, the University of Paris and elsewhere have investigated scattering from trabecular bone. Recent analysis of data from 23 human femur samples in vitro suggests that the Faran Cylinder Model and the Weak Scattering Model accurately predict frequency dependence of backscatter coefficient. Shear mode conversion of incident longitudinal waves may be a significant source of scattering loss. Other recent work involves the effect of errors of attenuation measurements on backscatter coefficient estimates. Backscatter measurements must be compensated for attenuation in order to estimate backscatter coefficient. However, attenuation is often overestimated because it is often measured using phase sensitive receivers that exhibit phase cancellation artifacts. Recent analysis of data from 16 human calcaneus samples in vitro suggests that backscatter coefficient estimates that are based on phase sensitive attenuation compensation tend to overestimate 1) average magnitude of backscatter coefficient at 500 kHz by a factor of about 1.6 plus or minus 0.3 (mean plus or minus standard deviation) and 2) average exponent (n) of frequency dependence by about 0.34 plus or minus 0.12 (where backscatter coefficient is assumed to be proportional to frequency to the nth power). JF - Journal of the Acoustical Society of America AU - Wear, KA AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Ave, Bldg 62, Rm 3108, Silver Spring, MD 20993, USA, keith.wear@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 VL - 123 IS - 5 SN - 0001-4966, 0001-4966 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Calcaneus KW - Data processing KW - Femur KW - Frequency dependence KW - Models KW - Bone (trabecular) KW - Standard deviation KW - Waves KW - W 30935:Food Biotechnology KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20813182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Recent+developments+in+modeling+and+measuring+scattering+from+trabecular+bone&rft.au=Wear%2C+KA&rft.aulast=Wear&rft.aufirst=KA&rft.date=2008-05-01&rft.volume=123&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Bone (trabecular); Frequency dependence; Models; Calcaneus; Standard deviation; Femur; Waves ER - TY - JOUR T1 - Options for Occupational Health Surveillance of Workers Potentially Exposed to Engineered Nanoparticles: State of the Science AN - 20785101; 8307092 AB - Objective: Health authorities, employers, and worker representatives are increasingly faced with making decisions about occupational health surveillance of workers potentially exposed to engineered nanoparticles. This article was developed to identify options that can be considered. Methods: The published scientific literature on health effects from engineered and incidental nanoparticles and the principles of occupational health surveillance were reviewed to describe possible options and the evidence base for them. Results: Various options for occupational health surveillance were identified. The options ranged from no action targeted to nanotechnology workers to an approach that includes documentation of the presence of engineered nanoparticles, identification of potentially exposed workers, and general and targeted medical testing. Conclusions: Although the first priority should be to implement appropriate primary preventive measures, additional efforts to monitor employee health may be warranted. Continued research is needed, and the collection of such information for exposure registries may be useful for future epidemiologic studies. JF - Journal of Occupational and Environmental Medicine AU - Schulte, P A AU - Trout, D AU - Zumwalde, R D AU - Kuempel, E AU - Geraci, CL AU - Castranova, V AU - Mundt, D J AU - Mundt, KA AU - Halperin, W E AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS-C14, Cincinnati, OH 45226-1998, USA, pas4@cdc.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 517 EP - 526 VL - 50 IS - 5 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Reviews KW - Occupational exposure KW - nanotechnology KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20785101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Options+for+Occupational+Health+Surveillance+of+Workers+Potentially+Exposed+to+Engineered+Nanoparticles%3A+State+of+the+Science&rft.au=Schulte%2C+P+A%3BTrout%2C+D%3BZumwalde%2C+R+D%3BKuempel%2C+E%3BGeraci%2C+CL%3BCastranova%2C+V%3BMundt%2C+D+J%3BMundt%2C+KA%3BHalperin%2C+W+E&rft.aulast=Schulte&rft.aufirst=P&rft.date=2008-05-01&rft.volume=50&rft.issue=5&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181651517 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Occupational exposure; Occupational health; Reviews; nanotechnology DO - http://dx.doi.org/10.1097/JOM.0b013e3181651517 ER - TY - JOUR T1 - 3,4-Dichloropropionanilide (DCPA) Inhibits T-Cell Activation by Altering the Intracellular Calcium Concentration following Store Depletion AN - 20693908; 8204090 AB - Stimulation of T cells through the T-cell receptor results in the activation of a series of signaling pathways that leads to the secretion of interleukin (IL)-2 and cell proliferation. Influx of calcium (Ca super(2+)) from the extracellular environment, following internal Ca super(2+) store depletion, provides the elevated and sustained intracellular calcium concentration ([Ca super(2+)] sub(i)) critical for optimal T-cell activation. Our laboratory has documented that exposure to the herbicide 3,4-dichloropropionanilide (DCPA) inhibits intracellular signaling events that have one or more Ca super(2+) dependent steps. Herein we report that DCPA attenuates the normal elevated and sustained [Ca super(2+)] sub(i) that follows internal store depletion in the human leukemic Jurkat T cell line and primary mouse T cells. DCPA did not alter the depletion of internal Ca super(2+) stores when stimulated by anti-CD3 or thapsigargin demonstrating that early inositol 1,4,5-triphosphate-mediated signaling and depletion of Ca super(2+) stores were unaffected. 2-Aminoethyldiphenol borate (2-APB) is known to alter the store-operated Ca super(2+) (SOC) influx that follows Ca super(2+) store depletion. Exposure of Jurkat cells to either DCPA or 50 mu M 2-APB attenuated the increase in [Ca super(2+)] sub(i) following thapsigargin or anti-CD3 induced store depletion in a similar manner. At low concentrations, 2-APB enhances SOC influx but this enhancement is abrogated in the presence of DCPA. This alteration in [Ca super(2+)] sub(i), when exposed to DCPA, significantly reduces nuclear levels of nuclear factor of activated T cells (NFAT) and IL-2 secretion. The plasma membrane polarization profile is not altered by DCPA exposure. Taken together, these data indicate that DCPA inhibits T-cell activation by altering Ca super(2+) homeostasis following store depletion. JF - Toxicological Sciences AU - Lewis, Tricia L AU - Brundage, Kathleen M AU - Brundage, Rodney A AU - Barnett, John B AD - Department of Microbiology, Immunology and Cell Biology. Center for Immunopathology and Microbial Pathogenesis, West Virginia University School of Medicine, Morgantown, West Viginia 26506. National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Morgantown, West Viginia 26506 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 97 EP - 107 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts; Immunology Abstracts; Calcium & Calcified Tissue Abstracts KW - Intracellular signalling KW - Calcium homeostasis KW - Interleukin 2 KW - double prime T-cell receptor KW - Inositol KW - Herbicides KW - Polarization KW - Calcium (extracellular) KW - Cell activation KW - Calcium (intracellular) KW - Leukemia KW - Calcium influx KW - Plasma membranes KW - thapsigargin KW - Transcription factors KW - Lymphocytes T KW - NF-AT protein KW - Cell proliferation KW - Signal transduction KW - T 2000:Cellular Calcium KW - F 06955:Immunomodulation & Immunopharmacology KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20693908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=3%2C4-Dichloropropionanilide+%28DCPA%29+Inhibits+T-Cell+Activation+by+Altering+the+Intracellular+Calcium+Concentration+following+Store+Depletion&rft.au=Lewis%2C+Tricia+L%3BBrundage%2C+Kathleen+M%3BBrundage%2C+Rodney+A%3BBarnett%2C+John+B&rft.aulast=Lewis&rft.aufirst=Tricia&rft.date=2008-05-01&rft.volume=103&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Calcium homeostasis; Intracellular signalling; Interleukin 2; double prime T-cell receptor; Inositol; Herbicides; Polarization; Calcium (extracellular); Calcium (intracellular); Cell activation; Leukemia; Calcium influx; thapsigargin; Plasma membranes; Transcription factors; Lymphocytes T; Cell proliferation; NF-AT protein; Signal transduction ER - TY - JOUR T1 - Occupation and bladder cancer in a hospital-based case-control study in Spain AN - 20690770; 8202611 AB - OBJECTIVES: We investigated the association between occupation and bladder cancer in a hospital-based case-control study conducted in Spain. METHODS: 1219 patients with transitional cell carcinoma of the urinary bladder and 1271 controls selected from 18 hospitals in Spain between June 1998 and September 2000 provided detailed information on life-time occupational history, smoking habits, medical history, and other factors. We used unconditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for each occupation and industry, adjusting for age, hospital region, smoking duration, and employment in a high-risk occupation for bladder cancer. RESULTS: Statistically significant increased risks were observed among men employed as machine operators in the printing industry (OR 5.4; 95% CI 1.6 to 17.7), among men employed in the transportation equipment industry (OR 1.6; 95% CI 1.1 to 2.6) and among those who had worked for greater than or equal to 10 years in the electrical/gas/sanitary services (OR 3.9; 95% CI 1.5 to 10.4) and in hotels and other lodgings (OR 3.1; 95% CI 1.3 to 7.3). Men who worked as miscellaneous mechanics and repairers (OR 2.0; 95% CI 1.1 to 3.6) and as supervisors in production occupations (OR 2.1; 95% CI 1.2 to 3.6) also had excess risks for bladder cancer. Male farmers and those who worked in crop and livestock production had decreased risks for bladder cancer. We found no significant associations between occupation or industry and bladder cancer risk among women. CONCLUSIONS: We did not observe excess bladder cancer risk for many of the occupations identified as being a priori at high risk. Examination of more detailed job exposure information should help clarify these associations. JF - Occupational and Environmental Medicine AU - Samanic, C M AU - Kogevinas, M AU - Silverman, D T AU - Tardon, A AU - Serra, C AU - Malats, N AU - Real, F X AU - Carrato, A AU - Garcia-Closas, R AU - Sala, M AU - Lloreta, J AU - Rothman, N AU - Dosemeci, M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 347 EP - 353 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 5 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Age KW - Spain KW - Printing industry KW - Crops KW - Cancer KW - hotels KW - Livestock KW - Smoking KW - urinary bladder KW - Transportation KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20690770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Occupation+and+bladder+cancer+in+a+hospital-based+case-control+study+in+Spain&rft.au=Samanic%2C+C+M%3BKogevinas%2C+M%3BSilverman%2C+D+T%3BTardon%2C+A%3BSerra%2C+C%3BMalats%2C+N%3BReal%2C+F+X%3BCarrato%2C+A%3BGarcia-Closas%2C+R%3BSala%2C+M%3BLloreta%2C+J%3BRothman%2C+N%3BDosemeci%2C+M&rft.aulast=Samanic&rft.aufirst=C&rft.date=2008-05-01&rft.volume=65&rft.issue=5&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - urinary bladder; Smoking; Historical account; Age; Transportation; Printing industry; Cancer; Crops; Occupational exposure; Livestock; hotels; Spain ER - TY - JOUR T1 - Chemical exposures at hazardous waste sites: Experiences from the United States and Poland AN - 20689260; 8178654 AB - The U.S. Agency for Toxic Substances and Disease Registry (ATSDR) and the Polish Nofer Institute of Occupational Health collaborate on issues related to hazardous chemical exposure at or near hazardous waste sites. This paper outlines the scope of hazardous chemical exposure in the United States and in Poland and identifies priority chemicals and chemical mixtures. Special attention is paid to exposures to metals and to evaluation of the health risks associated with those exposures. Studies in the United States indicate that exposure to hazardous waste site chemicals may be associated with an increased risk of adverse developmental - specifically cardiovascular and neurodevelopmental - effects. JF - Environmental Toxicology and Pharmacology AU - Pohl, H R AU - Tarkowski, S AU - Buczynska, A AU - Fay, M AU - De Rosa, CT AD - US Department of Health and Human Services, Atlanta, GA, USA, hpohl@cdc.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 283 EP - 291 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 25 IS - 3 SN - 1382-6689, 1382-6689 KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Chemicals KW - Metals KW - Cardiovascular system KW - USA KW - Poland KW - Neurotoxicity KW - Waste disposal sites KW - Hazardous wastes KW - Occupational exposure KW - Occupational health KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20689260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Chemical+exposures+at+hazardous+waste+sites%3A+Experiences+from+the+United+States+and+Poland&rft.au=Pohl%2C+H+R%3BTarkowski%2C+S%3BBuczynska%2C+A%3BFay%2C+M%3BDe+Rosa%2C+CT&rft.aulast=Pohl&rft.aufirst=H&rft.date=2008-05-01&rft.volume=25&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/10.1016%2Fj.etap.2007.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Metals; Waste disposal sites; Occupational exposure; Chemicals; Cardiovascular system; Neurotoxicity; Hazardous wastes; Occupational health; USA; Poland DO - http://dx.doi.org/10.1016/j.etap.2007.12.005 ER - TY - JOUR T1 - Estimating Consumer Familiarity with Health Terminology: A Context-based Approach AN - 20673332; 8199215 AB - OBJECTIVES: Effective health communication is often hindered by a "vocabulary gap" between language familiar to consumers and jargon used in medical practice and research. To present health information to consumers in a comprehensible fashion, we need to develop a mechanism to quantify health terms as being more likely or less likely to be understood by typical members of the lay public. Prior research has used approaches including syllable count, easy word list, and frequency count, all of which have significant limitations. DESIGN: In this article, we present a new method that predicts consumer familiarity using contextual information. The method was applied to a large query log data set and validated using results from two previously conducted consumer surveys. MEASUREMENTS: We measured the correlation between the survey result and the context-based prediction, syllable count, frequency count, and log normalized frequency count. RESULTS: The correlation coefficient between the context-based prediction and the survey result was 0.773 (p < 0.001), which was higher than the correlation coefficients between the survey result and the syllable count, frequency count, and log normalized frequency count (p less than or equal to 0.012). CONCLUSIONS: The context-based approach provides a good alternative to the existing term familiarity assessment methods. JF - Journal of the American Medical Informatics Association AU - Zeng-Treitler, Qing AU - Goryachev, Sergey AU - Tse, Tony AU - Keselman, Alla AU - Boxwala, Aziz AD - Decision Systems Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, Bethesda, MD. Aquilent, Inc., Laurel, MD Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 349 EP - 356 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 15 IS - 3 SN - 1067-5027, 1067-5027 KW - Biotechnology Research Abstracts (through 1992) KW - Communication KW - Language KW - Consumers KW - Familiarity KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20673332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Estimating+Consumer+Familiarity+with+Health+Terminology%3A+A+Context-based+Approach&rft.au=Zeng-Treitler%2C+Qing%3BGoryachev%2C+Sergey%3BTse%2C+Tony%3BKeselman%2C+Alla%3BBoxwala%2C+Aziz&rft.aulast=Zeng-Treitler&rft.aufirst=Qing&rft.date=2008-05-01&rft.volume=15&rft.issue=3&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Consumers; Familiarity; Language; Communication ER - TY - JOUR T1 - Anamnestic Protective Immunity to Bacillus anthracis Is Antibody Mediated but Independent of Complement and Fc Receptors AN - 20668629; 8198740 AB - The threat of bioterrorist use of Bacillus anthracis has focused urgent attention on the efficacy and mechanisms of protective immunity induced by available vaccines. However, the mechanisms of infection-induced immunity have been less well studied and defined. We used a combination of complement depletion along with immunodeficient mice and adoptive transfer approaches to determine the mechanisms of infection-induced protective immunity to B. anthracis. B- or T-cell-deficient mice lacked the complete anamnestic protection observed in immunocompetent mice. In addition, T-cell-deficient mice generated poor antibody titers but were protected by the adoptive transfer of serum from B. anthracis-challenged mice. Adoptively transferred sera were protective in mice lacking complement, Fc receptors, or both, suggesting that they operate independent of these effectors. Together, these results indicate that antibody-mediated neutralization provides significant protection in B. anthracis infection-induced immunity. JF - Infection and Immunity AU - Harvill, Eric T AU - Osorio, Manuel AU - Loving, Crystal L AU - Lee, Gloria M AU - Kelly, Vanessa K AU - Merkel, Tod J AD - Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802. Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2177 EP - 2182 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 5 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Antibodies KW - double prime Fc receptors KW - Lymphocytes T KW - Adoptive transfer KW - Immunodeficiency KW - Immunity KW - Vaccines KW - Bacillus anthracis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20668629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Anamnestic+Protective+Immunity+to+Bacillus+anthracis+Is+Antibody+Mediated+but+Independent+of+Complement+and+Fc+Receptors&rft.au=Harvill%2C+Eric+T%3BOsorio%2C+Manuel%3BLoving%2C+Crystal+L%3BLee%2C+Gloria+M%3BKelly%2C+Vanessa+K%3BMerkel%2C+Tod+J&rft.aulast=Harvill&rft.aufirst=Eric&rft.date=2008-05-01&rft.volume=76&rft.issue=5&rft.spage=2177&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antibodies; double prime Fc receptors; Immunodeficiency; Adoptive transfer; Lymphocytes T; Vaccines; Immunity; Bacillus anthracis ER - TY - JOUR T1 - The Role of Metabolic Biomarkers in Drug Toxicity Studies AN - 20281078; 8883069 AB - Metabolic profiling is a technique that can potentially provide more sensitive and specific biomarkers of toxicity than the current clinical measures benefiting preclinical and clinical drug studies. Both nuclear magnetic resonance (NMR) and mass spectrometry (MS) platforms have been used for metabolic profiling studies of drug toxicity. Not only can both techniques provide novel biomarker(s) of toxicity but the combination of both techniques gives a broader range of metabolites evaluated. Changes in metabolic patterns can provide insight into mechanism(s) of toxicity and help to eliminate a potentially toxic new chemical entity earlier in the developmental process. Metabolic profiling offers numerous advantages in toxicological research and screening as sample collection and preparation are relatively simple. Further, sample throughput, reproducibility, and accuracy are high. The area of drug toxicity of therapeutic compounds has already been impacted by metabolic profiling studies and will continue to be impacted as new, more specific biomarker(s) are found. In order for a biomarker or pattern of biomarkers to be accepted, it must be shown that they originate from the target tissue of interest. Metabolic profiling studies are amenable to any biofluid or tissue sample making it possible to link the changes noted in urine for instance as originating from renal injury. Additionally, the ease of sample collection makes it possible to follow a single animal or subject over time in order to determine whether and when the toxicity resolves itself. This review focuses on the advantages of metabolic profiling for drug toxicity studies. JF - Toxicology Mechanisms and Methods AU - Schnackenberg, Laura K AU - Beger, Richard D AD - Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 301 EP - 311 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 18 IS - 4 SN - 1537-6516, 1537-6516 KW - Toxicology Abstracts KW - Injuries KW - Urine KW - Reviews KW - Kidney KW - N.M.R. KW - Metabolites KW - Toxicity KW - Drugs KW - biomarkers KW - Mass spectroscopy KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20281078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=The+Role+of+Metabolic+Biomarkers+in+Drug+Toxicity+Studies&rft.au=Schnackenberg%2C+Laura+K%3BBeger%2C+Richard+D&rft.aulast=Schnackenberg&rft.aufirst=Laura&rft.date=2008-05-01&rft.volume=18&rft.issue=4&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376510701623193 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Injuries; Urine; Reviews; Kidney; Metabolites; N.M.R.; Toxicity; biomarkers; Drugs; Mass spectroscopy DO - http://dx.doi.org/10.1080/15376510701623193 ER - TY - JOUR T1 - Quantitative determination of cesium binding to ferric hexacyanoferrate: Prussian blue AN - 20241936; 8867014 AB - Ferric hexacyanoferrate (Fe sub(4) super(III)[Fe super(II)(CN) sub(6)] sub(3)), also known as insoluble Prussian blue (PB) is the active pharmaceutical ingredient (API) of the drug product, Radiogardase. Radiogardase is the first FDA approved medical countermeasure for the treatment of internal contamination with radioactive cesium (Cs) or thallium in the event of a major radiological incident such as a "dirty bomb". A number of pre-clinical and clinical studies have evaluated the use of PB as an investigational decorporation agent to enhance the excretion of metal cations. There are few sources of published in vitro data that detail the binding capacity of cesium to insoluble PB under various chemical and physical conditions. The study objective was to determine the in vitro binding capacity of PB APIs and drug products by evaluating certain chemical and physical factors such as medium pH, particle size, and storage conditions (temperature). In vitro experimental conditions ranged from pH 1 to 9, to cover the range of pH levels that PB may encounter in the gastrointestinal (GI) tract in humans. Measurements of cesium binding were made between 1 and 24 h, to cover gastric and intestinal tract residence time using a validated atomic emission spectroscopy (AES) method. The results indicated that pH, exposure time, storage temperature (affecting moisture content) and particle size play significant roles in the cesium binding to both the PB API and the drug product. The lowest cesium binding was observed at gastric pH of 1 and 2, whereas the highest cesium binding was observed at physiological pH of 7.5. It was observed that dry storage conditions resulted in a loss of moisture from PB, which had a significant negative effect on the PB cesium binding capacity at time intervals consistent with gastric residence. Differences were also observed in the binding capacity of PB with different particle sizes. Significant batch to batch differences were also observed in the binding capacity of some PB API and drug products. Our results suggest that certain physiochemical properties affect the initial binding capacity and the overall binding capacity of PB APIs and drug products during conditions that simulated gastric and GI residence time. These physiochemical properties can be utilized as quality attributes to monitor and predict drug product quality under certain manufacturing and storage conditions and may be utilized to enhance the clinical efficacy of PB. JF - Journal of Pharmaceutical and Biomedical Analysis AU - Faustino, Patrick J AU - Yang, Yongsheng AU - Progar, Joseph J AU - Brownell, Charles R AU - Sadrieh, Nakissa AU - May, Joan C AU - Leutzinger, Eldon AU - Place, David A AU - Duffy, Eric P AU - Houn, Florence AU - Loewke, Sally A AU - Mecozzi, Vincent J AU - Ellison, Christopher D AU - Khan, Mansoor A AU - Hussain, Ajaz S AU - Lyon, Robbe C AD - Division of Product Quality Research, Office of Testing and Research, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States, patrick.faustino@fda.hhs.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 114 EP - 125 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 47 IS - 1 SN - 0731-7085, 0731-7085 KW - Toxicology Abstracts KW - Prussian blue KW - Cesium binding KW - pH-profile KW - GI model KW - Particle size KW - Moisture KW - Atomic emission spectroscopy KW - Product quality KW - Temperature effects KW - Data processing KW - Cesium KW - Contamination KW - Heavy metals KW - Drug development KW - Spectroscopy KW - Cations KW - Storage conditions KW - Apis KW - Intestine KW - Pharmaceuticals KW - Excretion KW - Thallium KW - Gastrointestinal tract KW - Drugs KW - pH effects KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20241936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.atitle=Quantitative+determination+of+cesium+binding+to+ferric+hexacyanoferrate%3A+Prussian+blue&rft.au=Faustino%2C+Patrick+J%3BYang%2C+Yongsheng%3BProgar%2C+Joseph+J%3BBrownell%2C+Charles+R%3BSadrieh%2C+Nakissa%3BMay%2C+Joan+C%3BLeutzinger%2C+Eldon%3BPlace%2C+David+A%3BDuffy%2C+Eric+P%3BHoun%2C+Florence%3BLoewke%2C+Sally+A%3BMecozzi%2C+Vincent+J%3BEllison%2C+Christopher+D%3BKhan%2C+Mansoor+A%3BHussain%2C+Ajaz+S%3BLyon%2C+Robbe+C&rft.aulast=Faustino&rft.aufirst=Patrick&rft.date=2008-05-01&rft.volume=47&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.issn=07317085&rft_id=info:doi/10.1016%2Fj.jpba.2007.11.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Particle size; Temperature effects; Cesium; Data processing; Contamination; Heavy metals; Drug development; Spectroscopy; Cations; Storage conditions; Intestine; Pharmaceuticals; Thallium; Excretion; Gastrointestinal tract; pH effects; Drugs; Apis DO - http://dx.doi.org/10.1016/j.jpba.2007.11.049 ER - TY - JOUR T1 - Test early for verotoxin producing Escherichia coli AN - 20105034; 8300599 JF - British Medical Journal AU - Salmon, Roland L AU - Evans, Meirion R AU - Mason, Brendan W AU - Werber, Dirk AD - National Public Health Service for Wales, Temple of Peace and Health, Cardiff CF10 3NW Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1147 EP - 1148 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 336 IS - 7654 SN - 0959-8138, 0959-8138 KW - Microbiology Abstracts B: Bacteriology KW - verotoxin KW - Escherichia coli KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20105034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Medical+Journal&rft.atitle=Test+early+for+verotoxin+producing+Escherichia+coli&rft.au=Salmon%2C+Roland+L%3BEvans%2C+Meirion+R%3BMason%2C+Brendan+W%3BWerber%2C+Dirk&rft.aulast=Salmon&rft.aufirst=Roland&rft.date=2008-05-01&rft.volume=336&rft.issue=7654&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=British+Medical+Journal&rft.issn=09598138&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - verotoxin; Escherichia coli ER - TY - JOUR T1 - Effect of Gaseous Chlorine Dioxide on Indoor Microbial Contaminants AN - 19896322; 8380069 AB - Traditional and modern techniques for bioaerosol enumeration were used to evaluate the relative efficiency of gaseous chlorine dioxide (ClO2) in reducing the indoor microbial contamination under field and laboratory conditions. The field study was performed in a highly microbially contaminated house, which had had an undetected roof leak for an extended period of time and exhibited large areas of visible microbial growth. Air concentrations of culturable fungi and bacteria, total fungi determined by microscopic count and polymerase chain reaction (PCR) assays, endotoxin, and (1-3)-B-D-glucan were determined before and after the house was tented and treated with ClO2. The laboratory study was designed to evaluate the efficiency of ClO2 treatment against known concentrations of spores of Aspergillus versicolor and Stachybotrys chartarum on filter paper (surrogate for surface treatment). These species are commonly found in damp indoor environments and were detected in the field study. Upon analysis of the environmental data from the treated house, it was found that the culturable bacteria and fungi as well as total count of fungi (as determined by microscopic count and PCR) were decreased at least 85% after the ClO2 application. However, microscopic analyses of tape samples collected from surfaces after treatment showed that the fungal structures were still present on surfaces. There was no statistically significant change in airborne endotoxin and (1-3)-B-D-glucan concentration in the field study. The laboratory study supported these results and showed a nonsignificant increase in the concentration of (1-3)-B-D-glucan after ClO2 treatment. JF - Journal of the Air & Waste Management Association AU - Burton, N C AU - Adhikari, A AU - Iosslfova, Y AU - Grinshpun, SA AU - Reponen, T AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, and Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA Y1 - 2008/05// PY - 2008 DA - May 2008 VL - 58 IS - 5 SN - 1096-2247, 1096-2247 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Pollution Abstracts KW - Endotoxins KW - Houses KW - Data processing KW - Housing KW - Contamination KW - Fungi KW - Aspergillus versicolor KW - Airborne microorganisms KW - Statistical analysis KW - Chlorine KW - Stachybotrys chartarum KW - Microbial contamination KW - Filters KW - Chlorine dioxide KW - Residential areas KW - Filter paper KW - Polymerase chain reaction KW - Indoor environments KW - Contaminants KW - Spores KW - P 0000:AIR POLLUTION KW - A 01450:Environmental Pollution & Waste Treatment KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19896322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Effect+of+Gaseous+Chlorine+Dioxide+on+Indoor+Microbial+Contaminants&rft.au=Burton%2C+N+C%3BAdhikari%2C+A%3BIosslfova%2C+Y%3BGrinshpun%2C+SA%3BReponen%2C+T&rft.aulast=Burton&rft.aufirst=N&rft.date=2008-05-01&rft.volume=58&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Endotoxins; Chlorine dioxide; Houses; Data processing; Contamination; Fungi; Filter paper; Statistical analysis; Polymerase chain reaction; Spores; Contaminants; Filters; Housing; Airborne microorganisms; Residential areas; Chlorine; Microbial contamination; Indoor environments; Aspergillus versicolor; Stachybotrys chartarum ER - TY - JOUR T1 - Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR AN - 19891617; 8204083 AB - The liver-specific importer organic anion transporting polypeptide 1b2 (Oatp1b2, Slco1b2, also known as Oatp4 and Lst-1) and its human orthologs OATP1B1/1B3 transport a large variety of chemicals. Oatp1b2-null mice were engineered by homologous recombination and their phenotype was characterized. Oatp1b2 protein was absent in livers of Oatp1b2-null mice. Oatp1b2-null mice develop normally and breed well. However, adult Oatp1b2-null mice had moderate conjugated hyperbilirubinemia. Compared with wild-types, Oatp1b2-null mice had similar hepatic messenger RNA expression of most transporters examined except a higher Oatp1a4 but lower organic anion transporter 2. Intra-arterial injection of the mushroom toxin phalloidin (an Oatp1b2-specific substrate identified in vitro) caused cholestasis in wild-type mice but not in Oatp1b2-null mice. Hepatic uptake of fluorescence-labeled phalloidin was absent in Oatp1b2-null mice. Three hours after administration of microcystin-LR (a blue-green algae toxin), the binding of microcystin-LR to hepatic protein phosphatase 1/2a was much lower in Oatp1b2-null mice compared with wild-type mice. In contrast, Oatp1b2-null mice were transiently protected from decrease in bile flow induced by estradiol-17 beta -D-glucuronide, a common substrate for Oatps. Oatp1b2-null mice were completely resistant to the hepatotoxicity induced by phalloidin and microcystin-LR, but were similarly sensitive to alpha -amanitin-induced hepatotoxicity compared with wild-type mice. In conclusion, Oatp1b2-null mice display altered basic physiology and markedly decreased hepatic uptake/toxicity of phalloidin and microcystin-LR. Oatp1b2-null mice are useful in elucidating the role of Oatp1b2 and its human orthologs OATP1B1/1B3 in hepatic uptake and systemic disposition of toxic chemicals and therapeutic drugs. JF - Toxicological Sciences AU - Lu, Hong AU - Choudhuri, Supratim AU - Ogura, Kenichiro AU - Csanaky, Ivan L AU - Lei, Xiaohong AU - Cheng, Xingguo AU - Song, Pei-zhen AU - Klaassen, Curtis D AD - Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas. Center for Food Safety and Nutrition, Food and Drug Administration, College Park, Maryland. Department of Drug Metabolism and Molecular Toxicology, Tokyo University of Pharmacy and Life Science, Tokyo, Japan Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 35 EP - 45 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 1 SN - 1096-6080, 1096-6080 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Anions KW - Cholestasis KW - phalloidin KW - Phosphoprotein phosphatase KW - Disposition KW - Toxicity KW - Basidiocarps KW - hepatotoxicity KW - Toxins KW - organic anion transporting polypeptide KW - Gene expression KW - Cyanobacteria KW - Bile KW - Hyperbilirubinemia KW - Liver KW - Microcystin-LR KW - homologous recombination KW - Cyanophyta KW - Drugs KW - Algae KW - K 03410:Animal Diseases KW - X 24370:Natural Toxins KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Characterization+of+Organic+Anion+Transporting+Polypeptide+1b2-null+Mice%3A+Essential+Role+in+Hepatic+Uptake%2FToxicity+of+Phalloidin+and+Microcystin-LR&rft.au=Lu%2C+Hong%3BChoudhuri%2C+Supratim%3BOgura%2C+Kenichiro%3BCsanaky%2C+Ivan+L%3BLei%2C+Xiaohong%3BCheng%2C+Xingguo%3BSong%2C+Pei-zhen%3BKlaassen%2C+Curtis+D&rft.aulast=Lu&rft.aufirst=Hong&rft.date=2008-05-01&rft.volume=103&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Anions; Cholestasis; Phosphoprotein phosphatase; phalloidin; Disposition; Toxicity; Basidiocarps; organic anion transporting polypeptide; Toxins; hepatotoxicity; Gene expression; Hyperbilirubinemia; Bile; Liver; Microcystin-LR; homologous recombination; Drugs; Algae; Cyanobacteria; Cyanophyta ER - TY - JOUR T1 - Epidemiology of Hospitalizations Associated with Ulcers, Gastric Cancers, and Helicobacter pylori Infection among American Indian and Alaska Native Persons AN - 19807977; 8761983 AB - To describe the epidemiology of ulcers, gastric cancer, and Helicobacter pylori infection among American Indian (AI) and Alaska Native (AN) persons, we analyzed hospitalization discharge records with physician discharge diagnoses coded as ulcer, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma during 1980 to 2005, and H. pylori during 1996 to 2005 from the Indian Health Service Inpatient Dataset The average annual age-adjusted rate of hospitalizations that included an ulcer-associated condition was 232.4 per 100,000 AI/AN persons. The age-adjusted rate for gastric cancer was 14.2 per 100,000 persons. MALT lymphoma was listed as a discharge diagnosis at an age-adjusted rate of 6.1 per 100,000, and the age-adjusted rate of H. pybri discharge diagnoses was 282 per 100,000. The AI/AN persons living in the Alaska region and those greater than or equal to 65 years old had the highest rates of hospitalizations that listed ulcer-associated conditions, gastric cancers, MALT lymphoma, and H. pylori as a discharge diagnosis. JF - American Journal of Tropical Medicine and Hygiene AU - Demma, L J AU - Holman, R C AU - Sobel, J AU - Yorita, K L AU - Hennessy, T W AU - Paisano, EL AU - Cheek, JE AD - Enteric Disease Epidemiology Branch, Division of Foodborne, Bacterial, and Mycotic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 811 EP - 818 VL - 78 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Epidemiology KW - Ulcers KW - Mucosal-associated lymphoid tissue KW - Gastric cancer KW - Infection KW - Lymphoma KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19807977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Epidemiology+of+Hospitalizations+Associated+with+Ulcers%2C+Gastric+Cancers%2C+and+Helicobacter+pylori+Infection+among+American+Indian+and+Alaska+Native+Persons&rft.au=Demma%2C+L+J%3BHolman%2C+R+C%3BSobel%2C+J%3BYorita%2C+K+L%3BHennessy%2C+T+W%3BPaisano%2C+EL%3BCheek%2C+JE&rft.aulast=Demma&rft.aufirst=L&rft.date=2008-05-01&rft.volume=78&rft.issue=5&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epidemiology; Ulcers; Mucosal-associated lymphoid tissue; Infection; Gastric cancer; Lymphoma; Helicobacter pylori ER - TY - JOUR T1 - Trends in Intussusception Hospitalizations Among US Infants, 1993-2004: Implications for Monitoring the Safety of the New Rotavirus Vaccination Program AN - 19794377; 8202803 AB - OBJECTIVES. In 2006, a new rotavirus vaccine was recommended for routine immunization of US infants. Because a previous rotavirus vaccine was withdrawn in 1999 after it was associated with intussusception, monitoring for this adverse event with the new vaccine is important. The objectives of this study were to assess intussusception hospitalizations trends among US infants for 1993 to 2004; provide estimates of hospitalization rates for intussusception for 2002-2004; and assess variations in background rates by age, race/ethnicity, and surgical management. METHODS. By using the Healthcare Cost and Utilization Project's State Inpatient Database that captures US hospital discharges from 16 states representing 49% of the birth cohort during 1993-2004 and from 35 states representing 85% of the birth cohort in 2002-2004, we examined hospitalizations among infants (<12 months of age) with an International Classification of Disease, Ninth Revision, Clinical Modification code for intussusception (560.0). Incidence rates were calculated by using census data, and rate ratios with 95% confidence intervals were calculated by using Poisson regression data. RESULTS. Annual intussusception hospitalization rates declined 25% from 1993 to 2004 but have remained stable at similar to 35 cases per 100000 infants since 2000. Rates were very low for infants younger than 9 weeks (<5 per 100000) then increased rapidly, peaking at similar to 62 per 100000 at 26 to 29 weeks, before declining gradually to 26 per 100000 at 52 weeks. Compared with rates among non-Hispanic white infants (27 per 100000), rates were greater among non-Hispanic black infants (37 per 100000) and Hispanic infants (45 per 100000); however, rates did not differ by race/ethnicity for infants who were younger than 16 weeks. CONCLUSIONS. This assessment of US hospitalizations provides up-to-date and nationally representative prevaccine rates of intussusception. Because rates varied almost 12-fold by week of age and to a lesser extent by race/ethnicity during the age of vaccination, adjusting baseline rates to reflect the demographics of the vaccinated population will be crucial for assessing risk for intussusception after rotavirus vaccination. JF - Pediatrics AU - Tate, Jacqueline E AU - Simonsen, Lone AU - Viboud, Cecile AU - Steiner, Claudia AU - Patel, Manish M AU - Curns, Aaron T AU - Parashar, Umesh D AD - Division of Viral Diseases, Epidemiology Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Fogarty International Center, National Institutes of Health, Bethesda, Maryland. Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland Y1 - 2008/05// PY - 2008 DA - May 2008 SP - e1125 EP - e1132 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - 5 SN - 0031-4005, 0031-4005 KW - Risk Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - Rotavirus KW - census KW - vaccines KW - Age KW - Vaccination KW - immunization KW - Demography KW - Databases KW - USA KW - Health care KW - Classification KW - intussusception KW - Census KW - Vaccines KW - Side effects KW - Ethnic groups KW - Races KW - Infants KW - Hospitals KW - R2 23060:Medical and environmental health KW - W 30915:Pharmaceuticals & Vaccines KW - V 22400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19794377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Trends+in+Intussusception+Hospitalizations+Among+US+Infants%2C+1993-2004%3A+Implications+for+Monitoring+the+Safety+of+the+New+Rotavirus+Vaccination+Program&rft.au=Tate%2C+Jacqueline+E%3BSimonsen%2C+Lone%3BViboud%2C+Cecile%3BSteiner%2C+Claudia%3BPatel%2C+Manish+M%3BCurns%2C+Aaron+T%3BParashar%2C+Umesh+D&rft.aulast=Tate&rft.aufirst=Jacqueline&rft.date=2008-05-01&rft.volume=121&rft.issue=5&rft.spage=e1125&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Demography; Databases; Age; Classification; intussusception; Census; Vaccines; Vaccination; Races; Ethnic groups; Hospitals; Infants; census; immunization; vaccines; Health care; Side effects; Rotavirus; USA ER - TY - JOUR T1 - The impact of operating heavy equipment vehicles on lower back disorders AN - 19614799; 8681571 AB - Literature reviews examining the relationship between heavy equipment vehicle (HEV) operation and the development of musculoskeletal disorders have generally been qualitative in nature and have not employed an evidence-based assessment procedure. This research determines the extent to which whole-body vibration/shock and working postures are associated with lower back and neck disorders among HEV operators, while accounting for individual (i.e. age, gender, prior history of back or neck disorders) and occupational (i.e. material handling, climatic conditions, psychosocial factors) confounders. Published articles were obtained from a search of electronic databases and from bibliographies in the identified articles. A critical appraisal of these articles was conducted using an epidemiological appraisal instrument (Genaidy et al. 2007). The meta-analysis was conducted using statistical techniques employing fixed-effect and random-effect models. Eighteen articles reporting observational studies satisfied the inclusion criteria adopted for this research. The methodological qualities of the published studies ranged from marginal to average. The meta-relative risk was found to be 2.21, indicating that operators exposed to driving HEVs are at more than twice the risk of developing lower back pain in comparison to those not exposed to driving HEVs. Therefore, it seems possible that there is a causal relationship between working as a HEV operator and development of lower back disorders. Prospective cohort studies are urgently needed to confirm the outcomes of this evidence-based methodology (based in part on the meta-analysis) and the biological plausibility should be further explored. The reported findings point to a need for improved ergonomic design of HEVs. JF - Ergonomics AU - Waters, Thomas AU - Genaidy, Ash AU - Viruet, Heriberto Barriera AU - Makola, Mbulelo AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 602 EP - 636 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 51 IS - 5 SN - 0014-0139, 0014-0139 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - back pain KW - musculoskeletal system KW - Bibliographies KW - Gender KW - posture KW - Age KW - Materials handling KW - climatic conditions KW - Ergonomics KW - Hepatitis E virus KW - Reviews KW - Vibration KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19614799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=The+impact+of+operating+heavy+equipment+vehicles+on+lower+back+disorders&rft.au=Waters%2C+Thomas%3BGenaidy%2C+Ash%3BViruet%2C+Heriberto+Barriera%3BMakola%2C+Mbulelo&rft.aulast=Waters&rft.aufirst=Thomas&rft.date=2008-05-01&rft.volume=51&rft.issue=5&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130701779197 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Hepatitis E virus; Ergonomics; musculoskeletal system; Vibration; back pain; Reviews; Bibliographies; Materials handling; Gender; climatic conditions; posture; Historical account; Age DO - http://dx.doi.org/10.1080/00140130701779197 ER - TY - JOUR T1 - Interlaboratory Evaluation of Genomic Signatures for Predicting Carcinogenicity in the Rat AN - 19531412; 8204082 AB - The Critical Path Institute recently established the Predictive Safety Testing Consortium, a collaboration between several companies and the U.S. Food and Drug Administration, aimed at evaluating and qualifying biomarkers for a variety of toxicological endpoints. The Carcinogenicity Working Group of the Predictive Safety Testing Consortium has concentrated on sharing data to test the predictivity of two published hepatic gene expression signatures, including the signature by Fielden et al. (2007, TOXICOL: Sci. 99, 90-100) for predicting nongenotoxic hepatocarcinogens, and the signature by Nie et al. (2006, Mol. Carcinog. 45, 914-933) for predicting nongenotoxic carcinogens. Although not a rigorous prospective validation exercise, the consortium approach created an opportunity to perform a meta-analysis to evaluate microarray data from short-term rat studies on over 150 compounds. Despite significant differences in study designs and microarray platforms between laboratories, the signatures proved to be relatively robust and more accurate than expected by chance. The accuracy of the Fielden et al. signature was between 63 and 69%, whereas the accuracy of the Nie et al. signature was between 55 and 64%. As expected, the predictivity was reduced relative to internal validation estimates reported under identical test conditions. Although the signatures were not deemed suitable for use in regulatory decision making, they were deemed worthwhile in the early assessment of drugs to aid decision making in drug development. These results have prompted additional efforts to rederive and evaluate a QPCR-based signature using these samples. When combined with a standardized test procedure and prospective interlaboratory validation, the accuracy and potential utility in preclinical applications can be ascertained. JF - Toxicological Sciences AU - Fielden, Mark R AU - Nie, Alex AU - McMillian, Michael AU - Elangbam, Chandi S AU - Trela, Bruce A AU - Yang, Yi AU - Dunn, Robert TII AU - Dragan, Yvonne AU - Fransson-Stehen, Ronny AU - Bogdanffy, Matthew AU - Adams, Stephen P AU - Foster, William R AU - Chen, Shen-Jue AU - Rossi, Phil AU - Kasper, Peter AU - Jacobson-Kram, David AU - Tatsuoka, Kay S AU - Wier, Patrick J AU - Gollub, Jeremy AU - Halbert, Donald N AU - Roter, Alan AU - Young, Jamie K AU - Sina, Joseph F AU - Marlowe, Jennifer AU - Martus, Hans-Joerg AU - Aubrecht, Jiri AU - Olaharski, Andrew J AU - Roome, Nigel AU - Nioi, Paul AU - Pardo, Ingrid AU - Snyder, Ron AU - Perry, Richard AU - Lord, Peter AU - Mattes, William AU - Car, Bruce D AD - Roche Palo Alto, Palo Alto, California. Johnson & Johnson Pharmaceutical Research & Development, Raritan, New Jersey. GlaxoSmithKline, Research Triangle Park, North Carolina. Abbott Laboratories, Abbott Park, Illinois. Amgen, Thousand Oaks, California. AstraZeneca, Boston, Massachusetts. AstraZeneca, Soedertaelje, Sweden. Boehringer-Ingelheim, Ridgefield, Connecticut. Bristol-Myers Squibb, Princeton, New Jersey. Bristol-Myers Squibb, Wallingford, Connecticut. Critical Path Institute, Tucson, Arizona. Federal Institute for Drugs and Medical Devices, Bonn, Germany. Food and Drug Administration, Washington, DC. Iconix Biosciences, Mountain View, California. Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana. Merck Research Laboratories, West Point, Pennsylvania. Novartis Pharma AG, Basel, Switzerland. Pfizer, Groton, Connecticut. Sanofi-Aventis, Porcheville, France. Schering-Plough Research Institute, Summit, New Jersey. Wyeth Research, Chazy, New York Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 28 EP - 34 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 1 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Toxicology Abstracts KW - Data processing KW - Drug development KW - Carcinogens KW - Drug screening KW - biomarkers KW - Physical training KW - Gene expression KW - Decision making KW - Carcinogenicity KW - Reviews KW - Liver KW - genomics KW - X 24310:Pharmaceuticals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19531412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Interlaboratory+Evaluation+of+Genomic+Signatures+for+Predicting+Carcinogenicity+in+the+Rat&rft.au=Fielden%2C+Mark+R%3BNie%2C+Alex%3BMcMillian%2C+Michael%3BElangbam%2C+Chandi+S%3BTrela%2C+Bruce+A%3BYang%2C+Yi%3BDunn%2C+Robert+TII%3BDragan%2C+Yvonne%3BFransson-Stehen%2C+Ronny%3BBogdanffy%2C+Matthew%3BAdams%2C+Stephen+P%3BFoster%2C+William+R%3BChen%2C+Shen-Jue%3BRossi%2C+Phil%3BKasper%2C+Peter%3BJacobson-Kram%2C+David%3BTatsuoka%2C+Kay+S%3BWier%2C+Patrick+J%3BGollub%2C+Jeremy%3BHalbert%2C+Donald+N%3BRoter%2C+Alan%3BYoung%2C+Jamie+K%3BSina%2C+Joseph+F%3BMarlowe%2C+Jennifer%3BMartus%2C+Hans-Joerg%3BAubrecht%2C+Jiri%3BOlaharski%2C+Andrew+J%3BRoome%2C+Nigel%3BNioi%2C+Paul%3BPardo%2C+Ingrid%3BSnyder%2C+Ron%3BPerry%2C+Richard%3BLord%2C+Peter%3BMattes%2C+William%3BCar%2C+Bruce+D&rft.aulast=Fielden&rft.aufirst=Mark&rft.date=2008-05-01&rft.volume=103&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Decision making; Data processing; Carcinogenicity; Reviews; Liver; Drug development; Carcinogens; genomics; Drug screening; biomarkers; Physical training ER - TY - JOUR T1 - Reliable Comfort and Meaningfulness: Palliative Care Beyond Cancer AN - 57247709; 200819895 AB - To live well in the time left to them, patients with fatal chronic conditions need confidence that their healthcare system ensures excellent medical diagnosis and treatment, prevention of overwhelming symptoms, continuity and comprehensiveness of care, advance care planning, patient centred decisions, ands support for carers. Hospices and palliative care have improved these dimensions of quality for people dying from cancer. Applying those insights to other fatal chronic conditions could greatly improve the last part of life, although the endeavour entails substantial challenges. End of life care for elderly people will have to last for a long time: being disabled enough to need daily help now continues for an average of more than two years before death. Patients with non-malignant, long term illness are older and frailer than patients with cancer (as are their carers). Transfers between hospitals, nursing homes, and home care often engender delirium, depression, falls, treatment errors, and pressure ulcers, in addition to the common hospice problems of pain and loss. Entities that are often unfamiliar to hospices-such as social insurance programmes for poor people, long term care facilities, and disability transportation-will need to be partners in care. References. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Lynn, Joanne AD - Office Clinical Standards & Quality, Centers for Medicare & Medicaid Services, Baltimore, MD, US Joanne.Lynn@cms.hhs.gov Y1 - 2008/04/26/ PY - 2008 DA - 2008 Apr 26 SP - 958 EP - 959 PB - British Medical Association, BMJ Publishing Group, London UK VL - 336 IS - 7650 SN - 0959-535X, 0959-535X KW - Elderly people KW - Palliative care KW - Patients KW - Terminally ill people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57247709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Reliable+Comfort+and+Meaningfulness%3A+Palliative+Care+Beyond+Cancer&rft.au=Lynn%2C+Joanne&rft.aulast=Lynn&rft.aufirst=Joanne&rft.date=2008-04-26&rft.volume=336&rft.issue=7650&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.39535.656319.94 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Terminally ill people; Patients; Elderly people; Palliative care DO - http://dx.doi.org/10.1136/bmj.39535.656319.94 ER - TY - CPAPER T1 - Relationship of Hepatitis C Virus to Hepatocellular Carcinoma in Dialysis Patients. T2 - 43rd Annual Meeting of the European Association for the Study of the Liver AN - 40845819; 4818906 JF - 43rd Annual Meeting of the European Association for the Study of the Liver AU - Henderson, W A AU - Gill, J M AU - Kim, K H AU - Skanderson, M AU - Butt, A A Y1 - 2008/04/23/ PY - 2008 DA - 2008 Apr 23 KW - Hepatitis KW - Dialysis KW - Hepatocellular carcinoma KW - Tumors KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=43rd+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.atitle=Relationship+of+Hepatitis+C+Virus+to+Hepatocellular+Carcinoma+in+Dialysis+Patients.&rft.au=Henderson%2C+W+A%3BGill%2C+J+M%3BKim%2C+K+H%3BSkanderson%2C+M%3BButt%2C+A+A&rft.aulast=Henderson&rft.aufirst=W&rft.date=2008-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=43rd+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.issn=&rft_id=info:doi/ L2 - http://www.easl.ch/liver-meeting/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Biological exposure assessment to tetrachloroethylene for workers in the dry cleaning industry. AN - 69194474; 18412959 AB - The purpose of this study was to assess the feasibility of conducting biological tetrachloroethylene (perchloroethylene, PCE) exposure assessments of dry cleaning employees in conjunction with evaluation of possible PCE health effects. Eighteen women from four dry cleaning facilities in southwestern Ohio were monitored in a pilot study of workers with PCE exposure. Personal breathing zone samples were collected from each employee on two consecutive work days. Biological monitoring included a single measurement of PCE in blood and multiple measurements of pre- and post-shift PCE in exhaled breath and trichloroacetic acid (TCA) in urine. Post-shift PCE in exhaled breath gradually increased throughout the work week. Statistically significant correlations were observed among the exposure indices. Decreases in PCE in exhaled breath and TCA in urine were observed after two days without exposure to PCE. A mixed-effects model identified statistically significant associations between PCE in exhaled breath and airborne PCE time weighted average (TWA) after adjusting for a random participant effect and fixed effects of time and body mass index. Although comprehensive, our sampling strategy was challenging to implement due to fluctuating work schedules and the number (pre- and post-shift on three consecutive days) and multiplicity (air, blood, exhaled breath, and urine) of samples collected. PCE in blood is the preferred biological index to monitor exposures, but may make recruitment difficult. PCE TWA sampling is an appropriate surrogate, although more field intensive. Repeated measures of exposure and mixed-effects modeling may be required for future studies due to high within-subject variability. Workers should be monitored over a long enough period of time to allow the use of a lag term. JF - Environmental health : a global access science source AU - McKernan, Lauralynn T AU - Ruder, Avima M AU - Petersen, Martin R AU - Hein, Misty J AU - Forrester, Christy L AU - Sanderson, Wayne T AU - Ashley, David L AU - Butler, Mary A AD - Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA. LTaylor@cdc.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 12 VL - 7 KW - Solvents KW - 0 KW - Tetrachloroethylene KW - TJ904HH8SN KW - Index Medicus KW - Regression Analysis KW - Solvents -- analysis KW - Humans KW - Adult KW - Aged KW - Pilot Projects KW - Middle Aged KW - Body Mass Index KW - Female KW - Environmental Monitoring -- methods KW - Breath Tests KW - Tetrachloroethylene -- urine KW - Laundering KW - Occupational Exposure -- analysis KW - Tetrachloroethylene -- blood KW - Tetrachloroethylene -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69194474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+%3A+a+global+access+science+source&rft.atitle=Biological+exposure+assessment+to+tetrachloroethylene+for+workers+in+the+dry+cleaning+industry.&rft.au=McKernan%2C+Lauralynn+T%3BRuder%2C+Avima+M%3BPetersen%2C+Martin+R%3BHein%2C+Misty+J%3BForrester%2C+Christy+L%3BSanderson%2C+Wayne+T%3BAshley%2C+David+L%3BButler%2C+Mary+A&rft.aulast=McKernan&rft.aufirst=Lauralynn&rft.date=2008-04-15&rft.volume=7&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Environmental+health+%3A+a+global+access+science+source&rft.issn=1476-069X&rft_id=info:doi/10.1186%2F1476-069X-7-12 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-03 N1 - Date created - 2008-05-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Occup Hyg. 2001 Jan;45(1):71-81 [11137701] Int Arch Occup Environ Health. 2000 May;73(4):221-7 [10877027] Appl Occup Environ Hyg. 2002 May;17(5):352-9 [12018399] Mutat Res. 2003 Aug 5;539(1-2):9-18 [12948810] J Occup Environ Med. 2003 Nov;45(11):1152-7 [14610396] Environ Health Perspect. 1977 Dec;21:239-45 [612449] Int Arch Occup Environ Health. 1983;52(1):69-77 [6874093] Scand J Work Environ Health. 1983 Jun;9(3):273-81 [6612269] Am Ind Hyg Assoc J. 1983 Aug;44(8):600-5 [6624647] Br J Ind Med. 1986 Dec;43(12):814-24 [3801333] Arch Environ Health. 1988 Jul-Aug;43(4):292-8 [3415356] Am Ind Hyg Assoc J. 1990 Oct;51(10):566-74 [2251984] Arch Environ Health. 1991 May-Jun;46(3):174-8 [2039273] Anal Chem. 1992 May 1;64(9):1021-9 [1590585] Environ Health Perspect. 1995 Apr;103 Suppl 3:49-53 [7635112] IARC Monogr Eval Carcinog Risks Hum. 1995;63:159-221 [9097093] Am J Clin Nutr. 1998 May;67(5):934-9 [9583852] J Occup Environ Med. 1999 Jan;41(1):11-6 [9924715] J Air Waste Manag Assoc. 2001 Dec;51(12):1671-5 [15666472] JAMA. 2005 Apr 20;293(15):1861-7 [15840860] Environ Sci Technol. 2005 Oct 1;39(19):7741-8 [16245853] J Occup Environ Hyg. 2006 Nov;3(11):606-19 [17086665] J Toxicol Environ Health A. 2007 Apr 1;70(7):627-37 [17365617] Ann Occup Hyg. 2000 Jan;44(1):43-56 [10689758] Environ Health Perspect. 2000 Jun;108(6):569-73 [10856033] Am J Ind Med. 2001 Feb;39(2):121-32 [11170155] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1476-069X-7-12 ER - TY - JOUR T1 - Preventing household transmission of Shiga toxin-producing Escherichia coli O157 infection: promptly separating siblings might be the key. AN - 69156237; 18444854 AB - Preventing household transmission of Shiga toxin-producing Escherichia coli O157 (STEC O157) infection is important because of the ease of interpersonal transmission and the potential disease severity. We conducted a retrospective cohort study of households associated with an outbreak of STEC O157 infection in South Wales, United Kingdom, in autumn 2005. We investigated whether characteristics of the primary case patient or the household were predictors for secondary household transmission of STEC O157 infection. Furthermore, we estimated the proportion of cases that might be prevented by isolation (e.g., hospitalization) of the primary case patient immediately after the microbiological diagnosis and the number of patients with STEC O157 who would need to be isolated to prevent 1 case of hemolytic uremic syndrome. Based on dates of symptom onset, case patients in households were classified as having primary, coprimary, or secondary infection. Secondary cases were considered to be preventable if the secondary case patient's symptoms started >1 incubation period (4 days) after the date of microbiological diagnosis of the primary case. Eighty-nine (91%) of 98 eligible households were enrolled. Among 20 households (22%), 25 secondary cases were ascertained. Thirteen secondary cases (56%) occurred in siblings of the primary case patients; hemolytic uremic syndrome developed in 4 of these siblings. Presence of a sibling (risk ratio, 3.8; 95% confidence interval, 0.99-14.6) and young age (<5 years) of the primary case patient (risk ratio, 2.03; 95% confidence interval, 0.99-41.6) were independent predictors for households in which secondary cases occurred. Of the 15 secondary cases for which complete information was available, 7 (46%) might have been prevented. When restricting isolation to primary case patients who were aged <10 years and who had a sibling, we estimated the number of patients who would need to be isolated to prevent 1 case of hemolytic uremic syndrome to be 47 patients (95% confidence interval, 16-78 patients). Promptly separating pediatric patients with STEC O157 infection from their young siblings should be considered. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Werber, Dirk AU - Mason, Brendan W AU - Evans, Meirion R AU - Salmon, Roland L AD - Communicable Disease Surveillance Centre, National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff, United Kingdom. werberd@rki.de Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 1189 EP - 1196 VL - 46 IS - 8 KW - Index Medicus KW - Communicable Disease Control -- methods KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Child KW - Wales KW - Patient Isolation KW - Child, Preschool KW - Shiga-Toxigenic Escherichia coli -- isolation & purification KW - Escherichia coli Infections -- transmission KW - Escherichia coli O157 -- isolation & purification KW - Siblings KW - Escherichia coli Infections -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69156237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Preventing+household+transmission+of+Shiga+toxin-producing+Escherichia+coli+O157+infection%3A+promptly+separating+siblings+might+be+the+key.&rft.au=Werber%2C+Dirk%3BMason%2C+Brendan+W%3BEvans%2C+Meirion+R%3BSalmon%2C+Roland+L&rft.aulast=Werber&rft.aufirst=Dirk&rft.date=2008-04-15&rft.volume=46&rft.issue=8&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/10.1086%2F587670 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-28 N1 - Date created - 2008-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Infect Dis. 2008 Apr 15;46(8):1197-9 [18444855] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/587670 ER - TY - JOUR T1 - Occupational exposure to pesticides and risk of adult brain tumors. AN - 69110886; 18299277 AB - The authors examined incident glioma and meningioma risk associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 glioma and 195 meningioma patients diagnosed between 1994 and 1998 in three US hospitals. Controls were 765 patients admitted to the same hospitals for nonmalignant conditions. Occupational histories were collected during personal interviews. Exposure to pesticides was estimated by use of a questionnaire, combined with pesticide measurement data abstracted from published sources. Using logistic regression models, the authors found no association between insecticide and herbicide exposures and risk for glioma and meningioma. There was no association between glioma and exposure to insecticides or herbicides, in men or women. Women who reported ever using herbicides had a significantly increased risk for meningioma compared with women who never used herbicides (odds ratio = 2.4, 95% confidence interval: 1.4, 4.3), and there were significant trends of increasing risk with increasing years of herbicide exposure (p = 0.01) and increasing cumulative exposure (p = 0.01). There was no association between meningioma and herbicide or insecticide exposure among men. These findings highlight the need to go beyond job title to elucidate potential carcinogenic exposures within different occupations. JF - American journal of epidemiology AU - Samanic, Claudine M AU - De Roos, Anneclaire J AU - Stewart, Patricia A AU - Rajaraman, Preetha AU - Waters, Martha A AU - Inskip, Peter D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. samanicc@mail.nih.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 976 EP - 985 VL - 167 IS - 8 KW - Pesticides KW - 0 KW - Index Medicus KW - Meningeal Neoplasms -- epidemiology KW - Meningioma -- epidemiology KW - Humans KW - Aged KW - Glioma -- epidemiology KW - Risk Assessment KW - Meningeal Neoplasms -- etiology KW - Meningioma -- etiology KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - Glioma -- etiology KW - Incidence KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Brain Neoplasms -- epidemiology KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Pesticides -- toxicity KW - Brain Neoplasms -- etiology KW - Brain Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69110886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Occupational+exposure+to+pesticides+and+risk+of+adult+brain+tumors.&rft.au=Samanic%2C+Claudine+M%3BDe+Roos%2C+Anneclaire+J%3BStewart%2C+Patricia+A%3BRajaraman%2C+Preetha%3BWaters%2C+Martha+A%3BInskip%2C+Peter+D&rft.aulast=Samanic&rft.aufirst=Claudine&rft.date=2008-04-15&rft.volume=167&rft.issue=8&rft.spage=976&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwm401 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-15 N1 - Date created - 2008-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2001 Jan 11;344(2):79-86 [11150357] Int J Cancer. 1999 Jul 19;82(2):155-60 [10389745] Int J Cancer. 2002 May 10;99(2):252-9 [11979441] Am J Ind Med. 2002 Sep;42(3):214-27 [12210690] Cancer Causes Control. 2003 Mar;14(2):139-50 [12749719] J Neurosurg. 2003 Nov;99(5):848-53 [14609164] Int J Cancer. 2005 Jan 1;113(1):116-25 [15386358] Bull World Health Organ. 1962;26:75-91 [13888659] Int J Cancer. 2005 May 1;114(5):797-805 [15609304] Environ Health Perspect. 2005 May;113(5):546-51 [15866761] Occup Environ Med. 2005 Nov;62(11):786-92 [16234405] Int J Cancer. 2006 Mar 1;118(5):1321-4 [16152609] Occup Environ Med. 2006 Apr;63(4):267-72 [16556747] Int J Cancer. 2006 Sep 1;119(5):1152-7 [16570277] Am J Epidemiol. 2006 Oct 1;164(7):629-36 [16835295] J Agric Saf Health. 2006 Nov;12(4):255-74 [17131948] Occup Environ Med. 2007 Aug;64(8):509-14 [17537748] Cancer. 2007 Aug 1;110(3):471-6 [17580362] Am J Ind Med. 2004 May;45(5):395-407 [15095422] Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1583-8 [15466973] J Occup Med. 1979 Nov;21(11):745-8 [556268] Br J Ind Med. 1984 Feb;41(1):15-24 [6318800] Br J Cancer. 1985 Aug;52(2):259-70 [4027168] J Occup Med. 1986 Jul;28(7):497-501 [3734918] Scand J Work Environ Health. 1986 Oct;12(5):448-54 [3787216] Br J Ind Med. 1988 Feb;45(2):98-105 [3342201] J Occup Med. 1988 May;30(5):429-32 [3373347] Am J Epidemiol. 1988 Oct;128(4):778-85 [3421243] N Engl J Med. 1991 Jan 24;324(4):212-8 [1985242] Arch Environ Health. 1991 Mar-Apr;46(2):110-6 [2006895] Lancet. 1991 Oct 26;338(8774):1027-32 [1681353] Cancer. 1992 May 15;69(10):2541-7 [1568177] Br J Ind Med. 1992 Apr;49(4):220-5 [1571291] Scand J Work Environ Health. 1992 Jun;18(3):201-4 [1615295] Neuroepidemiology. 1992;11(4-6):267-76 [1337947] Int J Epidemiol. 1993 Aug;22(4):579-83 [8225728] Cancer Causes Control. 1993 Nov;4(6):529-38 [8280830] J Occup Med. 1993 Dec;35(12):1208-12 [8113924] Epidemiol Rev. 1995;17(2):382-414 [8654518] Int J Epidemiol. 1996 Aug;25(4):744-52 [8921451] Int J Cancer. 1997 Jul 29;72(3):389-93 [9247278] Am J Ind Med. 1998 Sep;34(3):252-60 [9698994] Int J Cancer. 2002 Apr 1;98(4):609-15 [11920623] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwm401 ER - TY - JOUR T1 - Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. AN - 69109009; 18413775 AB - Gene-knockout studies in mice suggest that INHA, encoding a subunit of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal cell tumors. It is not known whether genetic variation in the inhibin pathway also influences susceptibility to testicular germ cell tumors (TGCT), the most common testicular cancer in young men. To address this question, we conducted a case-control analysis (577 cases; 707 controls) of single-nucleotide polymorphisms (SNP) in genes in the inhibin pathway among participants in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study. Thirty-eight tagging SNPs in six genes (INHA, INHBA, INHBB, INHBC, INHBE, and SMAD4) were genotyped. Odds ratios (OR) and 95% confidence intervals (CI) relating variant genotypes to TGCT risk were calculated using unconditional logistic regression. Among White subjects, an elevated risk of TGCT was observed for carriers of the T allele of the INHA variant rs2059693 (CT genotype: OR, 1.33; 95% CI, 1.04-1.71; TT: OR, 1.60; 95% CI, 1.01-2.52; P(trend) = 0.008). The association with rs2059693 was stronger for nonseminomas, and for teratomas and teratocarcinomas in particular (N = 58; CT: OR, 1.63; 95% CI, 0.89-2.99; TT: OR, 4.54; 95% CI 2.00-10.3; P(trend) = 0.0008). We found no evidence of association with variants in the other investigated genes. These findings suggest that genetic variation in the INHA locus influences TGCT development. JF - Cancer research AU - Purdue, Mark P AU - Graubard, Barry I AU - Chanock, Stephen J AU - Rubertone, Mark V AU - Erickson, Ralph L AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20892, USA. purduem@mail.nih.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 3043 EP - 3048 VL - 68 IS - 8 KW - Inhibins KW - 57285-09-3 KW - Index Medicus KW - Genotype KW - Animals KW - Risk Factors KW - Military Personnel KW - Humans KW - Case-Control Studies KW - Disease Models, Animal KW - Mice KW - United States -- epidemiology KW - Male KW - Inhibins -- genetics KW - Genetic Variation KW - Polymorphism, Single Nucleotide KW - Neoplasms, Germ Cell and Embryonal -- epidemiology KW - Neoplasms, Germ Cell and Embryonal -- genetics KW - Testicular Neoplasms -- genetics KW - Testicular Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69109009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Genetic+variation+in+the+inhibin+pathway+and+risk+of+testicular+germ+cell+tumors.&rft.au=Purdue%2C+Mark+P%3BGraubard%2C+Barry+I%3BChanock%2C+Stephen+J%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L%3BMcGlynn%2C+Katherine+A&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2008-04-15&rft.volume=68&rft.issue=8&rft.spage=3043&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-07-5852 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Reprod. 2004 Aug;19(8):1760-4 [15205401] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Mol Cell Endocrinol. 2004 Oct 15;225(1-2):73-6 [15451570] J Obstet Gynaecol Br Commonw. 1973 Jul;80(7):651-3 [4723959] Acta Genet Med Gemellol (Roma). 1981;30(3):189-202 [6805197] Acta Genet Med Gemellol (Roma). 1984;33(1):131-9 [6429992] Cancer. 1989 Aug 15;64(4):956-61 [2545331] Br J Urol. 1990 Sep;66(3):315-7 [2119845] Nature. 1992 Nov 26;360(6402):313-9 [1448148] Eur Urol. 1993;23(1):54-9; discussion 60-1 [8477778] BMJ. 1994 May 28;308(6941):1393-9 [7912596] Cancer Causes Control. 1995 Nov;6(6):519-24 [8580300] Nature. 1996 Dec 5;384(6608):470-4 [8945475] Cancer. 1997 Sep 1;80(5):929-35 [9307193] Br J Cancer. 1997;76(9):1191-8 [9365168] Lancet. 1997 Dec 13;350(9093):1723-8 [9413462] J Clin Endocrinol Metab. 1998 Mar;83(3):969-75 [9506758] Mol Endocrinol. 1999 Jun;13(6):851-65 [10379885] Genet Epidemiol. 2005 Apr;28(3):261-72 [15637718] Nature. 2005 Oct 27;437(7063):1299-320 [16255080] Nat Genet. 2005 Dec;37(12):1320-2 [16258542] Ann N Y Acad Sci. 2005 Dec;1061:173-82 [16467266] Hum Genet. 2006 Aug;120(1):1-21 [16645853] Fertil Steril. 2007 Jan;87(1):210-2 [17084394] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):77-83 [17220333] Am J Epidemiol. 2007 Feb 15;165(4):355-63 [17110638] Dev Biol. 2000 Apr 15;220(2):225-37 [10753512] Nat Med. 2000 Jun;6(6):637-41 [10835679] Hum Reprod. 2000 Dec;15(12):2644-9 [11098038] Eur J Endocrinol. 2001 Dec;145(6):779-84 [11720904] Cancer Invest. 2001;19(8):842-53 [11768038] Mol Endocrinol. 2002 Feb;16(2):213-20 [11818495] Science. 2002 Jun 21;296(5576):2225-9 [12029063] Hum Reprod. 2002 Jul;17(7):1741-5 [12093833] Am J Public Health. 2002 Dec;92(12):1900-4 [12453804] Semin Reprod Med. 2004 Aug;22(3):177-85 [15319820] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-07-5852 ER - TY - JOUR T1 - Let Patients Control the Purse Strings AN - 57256990; 200818733 AB - As the burden of disease shifts from acute to chronic care, governments are having to reshape health services. The UK health white paper, Our Health, Our Care, Our Say, published in January 2006, outlines four goals: greater prevention and early intervention, more choice and a louder voice for patients, more support for people with long term needs, and tackling inequalities. Other countries in the Organisation for Economic Cooperation and Development have stated similar objectives. If governments are serious about these aims, they would do well to learn from recent innovation in social care. In the United Kingdom, the Netherlands, the United States, and Germany, the delivery of social care services is being transformed through the introduction of individualised funding mechanisms, such as direct payments and individual budgets. These mechanisms allow services to be more accurately tailored to individual needs and could particularly benefit patients needing long term health care. Tables, Figures, References. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Alakeson, Vidhya AD - Office Assistant Secretary for Planning & Evaluation, Department Health & Human Services, Washington, DC US vidhya.alakeson@hhs.gov Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 SP - 807 EP - 809 PB - British Medical Association, BMJ Publishing Group, London UK VL - 336 IS - 7648 SN - 0959-535X, 0959-535X KW - Health care KW - Patents KW - UK KW - Budgets KW - National health services KW - Control KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57256990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Let+Patients+Control+the+Purse+Strings&rft.au=Alakeson%2C+Vidhya&rft.aulast=Alakeson&rft.aufirst=Vidhya&rft.date=2008-04-12&rft.volume=336&rft.issue=7648&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.39524.400498.AD LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - National health services; Health care; Budgets; Control; Patents; UK DO - http://dx.doi.org/10.1136/bmj.39524.400498.AD ER - TY - CPAPER T1 - Increased Distributional Variance of Mitochondrial DNA Content Associated with Prostate Cancer Development. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873452; 4824369 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Furusawa, Jun AU - Mizumachi, Takatsugu AU - Muskhelishvili, Levan AU - Naito, Akihiro AU - Fan, Chun-Yang AU - Siegel, Eric R AU - Kadlubar, Fred F AU - Kumar, Udaya AU - Higuchi, Masahiro Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Mitochondrial DNA KW - Prostate cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Increased+Distributional+Variance+of+Mitochondrial+DNA+Content+Associated+with+Prostate+Cancer+Development.&rft.au=Furusawa%2C+Jun%3BMizumachi%2C+Takatsugu%3BMuskhelishvili%2C+Levan%3BNaito%2C+Akihiro%3BFan%2C+Chun-Yang%3BSiegel%2C+Eric+R%3BKadlubar%2C+Fred+F%3BKumar%2C+Udaya%3BHiguchi%2C+Masahiro&rft.aulast=Furusawa&rft.aufirst=Jun&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D Np63a Alters Keratinocyte Growth Regulation via the Activation of the NF-a B Subunit c-Rel. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873047; 4824500 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - King, Kathryn E AU - Ponnamperuma, Roshini M AU - Allen, Clint AU - Chen, Zhong AU - Van Waes, Carter AU - Weinberg, Wendy C Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Keratinocytes KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=D+Np63a+Alters+Keratinocyte+Growth+Regulation+via+the+Activation+of+the+NF-a+B+Subunit+c-Rel.&rft.au=King%2C+Kathryn+E%3BPonnamperuma%2C+Roshini+M%3BAllen%2C+Clint%3BChen%2C+Zhong%3BVan+Waes%2C+Carter%3BWeinberg%2C+Wendy+C&rft.aulast=King&rft.aufirst=Kathryn&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Non-Mutational Mechanisms in Cancer Cell Drug Resistance. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866783; 4822761 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Chekhun, Vasyl' F AU - Filkowski, Jody AU - Meservy, James AU - Ilnytskyy, Yaroslav AU - Mykytenko, Dmytro AU - Tryndyak, Volodymyr AU - Pogribny, Igor P AU - Kovalchuk, Olga Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Drug resistance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Role+of+Non-Mutational+Mechanisms+in+Cancer+Cell+Drug+Resistance.&rft.au=Chekhun%2C+Vasyl%27+F%3BFilkowski%2C+Jody%3BMeservy%2C+James%3BIlnytskyy%2C+Yaroslav%3BMykytenko%2C+Dmytro%3BTryndyak%2C+Volodymyr%3BPogribny%2C+Igor+P%3BKovalchuk%2C+Olga&rft.aulast=Chekhun&rft.aufirst=Vasyl%27&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxidant-Induced Apoptosis is Mediated by Oxidation of the Actin-Regulatory Protein Cofilin. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866595; 4823023 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Zdanov, Stephanie AU - Klamt, Fabio AU - Levine, Rodney L AU - Shacter, Emily Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Oxidation KW - Cofilin KW - Apoptosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Oxidant-Induced+Apoptosis+is+Mediated+by+Oxidation+of+the+Actin-Regulatory+Protein+Cofilin.&rft.au=Zdanov%2C+Stephanie%3BKlamt%2C+Fabio%3BLevine%2C+Rodney+L%3BShacter%2C+Emily&rft.aulast=Zdanov&rft.aufirst=Stephanie&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Upregulation of Interleukin 13 Receptor (IL-13R) by Adrenomedullin (AM) in Human Prostate Cancer Model T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864329; 4820789 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Joshi, Bharat H AU - Leland, Pamela AU - Calvo, Alfonso AU - Montuenga, Luis AU - Green, Jeffrey AU - Puri, Raj K Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate cancer KW - Adrenomedullin KW - Interleukin 13 receptors KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=In+Vivo+Upregulation+of+Interleukin+13+Receptor+%28IL-13R%29+by+Adrenomedullin+%28AM%29+in+Human+Prostate+Cancer+Model&rft.au=Joshi%2C+Bharat+H%3BLeland%2C+Pamela%3BCalvo%2C+Alfonso%3BMontuenga%2C+Luis%3BGreen%2C+Jeffrey%3BPuri%2C+Raj+K&rft.aulast=Joshi&rft.aufirst=Bharat&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MicroRNA miR-16 Linked to the Development and Progression of B Cell Malignancies in the NZB de novo Murine Model of CLL. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859882; 4822941 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Salerno, Erica AU - Scaglione, Brian AU - Coffman, Frederick AU - Fernandes, Helen AU - Marti, Gerald E AU - Baskar, Sivasubramanian AU - Rader, Christoph AU - Raveche, Elizabeth Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lymphocytes B KW - Animal models KW - Malignancy KW - MiRNA KW - Chronic lymphatic leukemia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=MicroRNA+miR-16+Linked+to+the+Development+and+Progression+of+B+Cell+Malignancies+in+the+NZB+de+novo+Murine+Model+of+CLL.&rft.au=Salerno%2C+Erica%3BScaglione%2C+Brian%3BCoffman%2C+Frederick%3BFernandes%2C+Helen%3BMarti%2C+Gerald+E%3BBaskar%2C+Sivasubramanian%3BRader%2C+Christoph%3BRaveche%2C+Elizabeth&rft.aulast=Salerno&rft.aufirst=Erica&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The SNP rs380390 of Complement Factor H Gene is Associated with the Risk of Lung Cancer and Interacts with ERCC6 SNP rs3793784. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40858132; 4822641 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Zhang, Xuemei AU - Guo, Yongli AU - Tuo, Jingsheng AU - Green, Bridgett AU - Wise, Carolyn AU - Kadlubar, Susan AU - Kadlubar, Fred F AU - Lin, Dongxin AU - Ning, Baitang Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - Single-nucleotide polymorphism KW - Complement factor H KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+SNP+rs380390+of+Complement+Factor+H+Gene+is+Associated+with+the+Risk+of+Lung+Cancer+and+Interacts+with+ERCC6+SNP+rs3793784.&rft.au=Zhang%2C+Xuemei%3BGuo%2C+Yongli%3BTuo%2C+Jingsheng%3BGreen%2C+Bridgett%3BWise%2C+Carolyn%3BKadlubar%2C+Susan%3BKadlubar%2C+Fred+F%3BLin%2C+Dongxin%3BNing%2C+Baitang&rft.aulast=Zhang&rft.aufirst=Xuemei&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Mechanisms of Differential Apoptosis between Human Melanoma Cell Lines UACC903 and UACC903(+6) Revealed by Mitochondria-focused cDNA Microarrays T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856985; 4821894 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wang, Bi-Dar AU - Zhang, Qiuyang AU - Nguyen, AnhThu AU - Wu, Jun AU - He, Ping AU - St Laurent, Georges AU - Rennert, Owen AU - Su, Yan A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Melanoma KW - DNA microarrays KW - Mitochondria KW - Apoptosis KW - Molecular modelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Molecular+Mechanisms+of+Differential+Apoptosis+between+Human+Melanoma+Cell+Lines+UACC903+and+UACC903%28%2B6%29+Revealed+by+Mitochondria-focused+cDNA+Microarrays&rft.au=Wang%2C+Bi-Dar%3BZhang%2C+Qiuyang%3BNguyen%2C+AnhThu%3BWu%2C+Jun%3BHe%2C+Ping%3BSt+Laurent%2C+Georges%3BRennert%2C+Owen%3BSu%2C+Yan+A&rft.aulast=Wang&rft.aufirst=Bi-Dar&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BMI, NSAIDs and Multiple Disease Outcomes. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855285; 4822597 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Huang, Wen-Yi AU - Weiss, Jocelyn AU - Purdue, Mark AU - Berndt, Sonja AU - Daugherty, Sarah AU - Pinsky, Paul F AU - Weissfeld, Joel L AU - Hayes, Richard B Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Nonsteroidal antiinflammatory drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=BMI%2C+NSAIDs+and+Multiple+Disease+Outcomes.&rft.au=Huang%2C+Wen-Yi%3BWeiss%2C+Jocelyn%3BPurdue%2C+Mark%3BBerndt%2C+Sonja%3BDaugherty%2C+Sarah%3BPinsky%2C+Paul+F%3BWeissfeld%2C+Joel+L%3BHayes%2C+Richard+B&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Different Patterns of miRNA Expression Distinguish Genotoxic and Non-genotoxic Rat Hepatocarcinogenesis T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854652; 4820264 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Tryndyak, Volodymyr AU - Muskhelishvili, Levan AU - Bagnyukova, Tetyana AU - Montgomery, Beverly AU - Beland, Frederick AU - Pogribny, Igor P Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Genotoxicity KW - MiRNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Different+Patterns+of+miRNA+Expression+Distinguish+Genotoxic+and+Non-genotoxic+Rat+Hepatocarcinogenesis&rft.au=Tryndyak%2C+Volodymyr%3BMuskhelishvili%2C+Levan%3BBagnyukova%2C+Tetyana%3BMontgomery%2C+Beverly%3BBeland%2C+Frederick%3BPogribny%2C+Igor+P&rft.aulast=Tryndyak&rft.aufirst=Volodymyr&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carcinogenic Potential of Tar-based Vaginal Douche Products and Cervical Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853748; 4822115 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Haverkos, Harry W AU - Boring, Daniel AU - Kruhlak, Naomi L AU - Matthews, Edwin J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cervical cancer KW - Carcinogenicity KW - Vagina KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Carcinogenic+Potential+of+Tar-based+Vaginal+Douche+Products+and+Cervical+Cancer&rft.au=Haverkos%2C+Harry+W%3BBoring%2C+Daniel%3BKruhlak%2C+Naomi+L%3BMatthews%2C+Edwin+J&rft.aulast=Haverkos&rft.aufirst=Harry&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumorigenicity of Acrylamide and its Metabolite Glycidamide in the Neonatal Mouse Bioassay T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852762; 4822129 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Von Tungeln, Linda S AU - Doerge, Daniel R AU - da Costa, Goncalo Gamboa AU - Marques, M Matilde AU - Beland, Frederick A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Metabolites KW - Neonates KW - Bioassays KW - Acrylamide KW - Tumorigenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Tumorigenicity+of+Acrylamide+and+its+Metabolite+Glycidamide+in+the+Neonatal+Mouse+Bioassay&rft.au=Von+Tungeln%2C+Linda+S%3BDoerge%2C+Daniel+R%3Bda+Costa%2C+Goncalo+Gamboa%3BMarques%2C+M+Matilde%3BBeland%2C+Frederick+A&rft.aulast=Von+Tungeln&rft.aufirst=Linda&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acrylamide Increases Levels of Nitric Oxide Synthase and Cox-2 in Normal Breast Cell In Vitro T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852402; 4821964 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Lyn-Cook Jr., L.E. AU - Tareke, E AU - Word, B AU - Starlard-Davenport, A AU - Lyn-Cook, B D AU - Hammons, G J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Nitric-oxide synthase KW - Acrylamide KW - Cyclooxygenase-2 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Acrylamide+Increases+Levels+of+Nitric+Oxide+Synthase+and+Cox-2+in+Normal+Breast+Cell+In+Vitro&rft.au=Lyn-Cook+Jr.%2C+L.E.%3BTareke%2C+E%3BWord%2C+B%3BStarlard-Davenport%2C+A%3BLyn-Cook%2C+B+D%3BHammons%2C+G+J&rft.aulast=Lyn-Cook+Jr.&rft.aufirst=L.E.&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Auto-oxidation and Oligomerization of Protein S on the Apoptotic Cell Surface is Required for MerTK-mediated Phagocytosis of Apoptotic Cells T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40851952; 4821865 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Uehara, Hiroshi AU - Shacter, Emily Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Apoptosis KW - Oligomerization KW - Phagocytosis KW - Cell surface KW - Protein S KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40851952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Auto-oxidation+and+Oligomerization+of+Protein+S+on+the+Apoptotic+Cell+Surface+is+Required+for+MerTK-mediated+Phagocytosis+of+Apoptotic+Cells&rft.au=Uehara%2C+Hiroshi%3BShacter%2C+Emily&rft.aulast=Uehara&rft.aufirst=Hiroshi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Indole-3-carbinol (I3C) Reactives p16 in Pancreatic Cancer Cells through Hypomethylation T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40850840; 4821786 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Lyn-Cook, Beverly D AU - Haefele, Aaron AU - Word, Beverly AU - Hammons, George Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Pancreatic cancer KW - Indole-3-carbinol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40850840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Indole-3-carbinol+%28I3C%29+Reactives+p16+in+Pancreatic+Cancer+Cells+through+Hypomethylation&rft.au=Lyn-Cook%2C+Beverly+D%3BHaefele%2C+Aaron%3BWord%2C+Beverly%3BHammons%2C+George&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Bombesin marine toxin conjugates inhibit the growth of lung cancer cells. AN - 70466440; 18336841 AB - Hemiasterlin (Hem) and dolastatin (Dol) are marine natural products which are cytotoxic for cancer cells. Hem, a tripeptide, and Dol, a hexapeptide, were conjugated with linkers (L) to the universal BB agonist DPhe-Gln-Trp-Ala-Val-betaAla-His-Phe-Nle-NH2(BA1) and the effects of the Hem-BB and Dol-BB conjugates investigated on NCI-H1299 lung cancer cells. Hem-LA-BA1 and Hem-LB-BA1 inhibited specific (125I-Tyr4)BB binding to NCI-H1299 cells, which have BB2 receptors (R), with IC50 values of 15 and 25 nM, respectively. Addition of Hem-LA-BA1 and Hem-LB-BA1 to Fura-2 AM loaded cells containing BB2R, caused elevated cytosolic Ca2+. In a growth assay, Hem-LA-BA1 and Hem-LB-BA1 inhibited the proliferation of NCI-H1299 cells. Dol-succinamide (Dols)-LD-BA1 and Dols-LE-BA1 bound with high affinity to NCI-H1299 cells and elevated cytosolic Ca2+, but did not inhibit the proliferation of NCI-H1299 cells. Also, Hem-LA-BA1 inhibited 125I-DTyr-Gln-Trp-Ala-Val-betaAla-His-Phe-Nle-NH2 (BA2) binding to Balb/3T3 cells transfected with BB1R or BB2R as well as with BRS-3 with IC50 values of 130, 8, and 540 nM, respectively. These results show that Hem-BB conjugates are cytotoxic for cancer cells containing BB2R. JF - Life sciences AU - Moody, Terry W AU - Pradhan, Tapas AU - Mantey, Samuel A AU - Jensen, Robert T AU - Dyba, Marcin AU - Moody, Deborah AU - Tarasova, Nadya I AU - Michejda, Christopher J AD - Department of Health and Human Services, NCI Office of the Director, CCR, Bethesda, MD 20892 USA. moodyt@mail.nih.gov Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 SP - 855 EP - 861 VL - 82 IS - 15-16 SN - 0024-3205, 0024-3205 KW - Antineoplastic Agents KW - 0 KW - Marine Toxins KW - Oligopeptides KW - Prodrugs KW - Receptors, Drug KW - hemiasterlin KW - Bombesin KW - PX9AZU7QPK KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Calcium -- metabolism KW - Cytosol -- metabolism KW - Animals KW - 3T3 Cells KW - Cell Survival -- drug effects KW - Receptors, Drug -- drug effects KW - Prodrugs -- pharmacology KW - Humans KW - Mice KW - Cell Line, Tumor KW - Protein Binding KW - Marine Toxins -- pharmacology KW - Bombesin -- chemistry KW - Lung Neoplasms -- drug therapy KW - Oligopeptides -- pharmacology KW - Bombesin -- pharmacology KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology KW - Marine Toxins -- chemistry KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70466440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Bombesin+marine+toxin+conjugates+inhibit+the+growth+of+lung+cancer+cells.&rft.au=Moody%2C+Terry+W%3BPradhan%2C+Tapas%3BMantey%2C+Samuel+A%3BJensen%2C+Robert+T%3BDyba%2C+Marcin%3BMoody%2C+Deborah%3BTarasova%2C+Nadya+I%3BMichejda%2C+Christopher+J&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2008-04-09&rft.volume=82&rft.issue=15-16&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/10.1016%2Fj.lfs.2008.01.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anticancer Drug Des. 1999 Dec;14(6):473-86 [10834269] Curr Pharm Des. 2005;11(9):1167-80 [15853664] Clin Cancer Res. 2002 Apr;8(4):1139-46 [11948125] J Nucl Med. 2003 May;44(5):823-31 [12732685] Biochemistry. 2003 Nov 25;42(46):13484-95 [14621994] J Biol Chem. 2004 May 28;279(22):23580-9 [15016826] Biochem Pharmacol. 1973 Dec 1;22(23):3099-108 [4202581] J Clin Endocrinol Metab. 1981 Dec;53(6):1310-2 [6117568] Science. 1981 Dec 11;214(4526):1246-8 [6272398] Nature. 1985 Aug 29-Sep 4;316(6031):823-6 [2993906] Biochem Biophys Res Commun. 1987 Aug 31;147(1):189-95 [2443131] Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):395-9 [1671171] Neuron. 1991 Mar;6(3):421-30 [1848080] Pulm Pharmacol Ther. 1999;12(5):291-302 [10545285] Biochemistry. 1999 Oct 26;38(43):14302-10 [10572005] Mol Endocrinol. 1990 Dec;4(12):1956-63 [1707129] J Biol Chem. 1993 Mar 15;268(8):5979-84 [8383682] J Biol Chem. 1995 Feb 17;270(7):3346-52 [7852420] Jpn J Cancer Res. 1997 Mar;88(3):316-27 [9140117] J Biol Chem. 1997 Oct 10;272(41):26062-71 [9325344] Eur J Pharmacol. 1998 Feb 19;343(2-3):275-87 [9570477] Clin Cancer Res. 1999 Mar;5(3):525-31 [10100703] J Am Chem Soc. 2005 Dec 21;127(50):17667-71 [16351096] Anticancer Agents Med Chem. 2006 Jan;6(1):33-40 [16475925] Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10403-7 [16801542] J Pharmacol Exp Ther. 2006 Sep;318(3):1265-72 [16766720] Cell Mol Life Sci. 2006 Oct;63(19-20):2377-86 [17006627] Int J Oncol. 2007 Jun;30(6):1453-9 [17487366] Anticancer Agents Med Chem. 2007 May;7(3):345-57 [17504160] Eur J Nucl Med Mol Imaging. 2007 Aug;34(8):1228-38 [17287960] Receptors Channels. 1998;6(3):201-12 [10100328] Curr Med Chem. 2001 Jul;8(9):1093-122 [11472243] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.lfs.2008.01.019 ER - TY - CPAPER T1 - A Comparative Study of Host Cell Responses to M._tuberculosis PE_PGRS Proteins T2 - Third International Conference on TB Vaccines for the World (TBV 2008) AN - 40967921; 4869231 JF - Third International Conference on TB Vaccines for the World (TBV 2008) AU - Singh, P P Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 KW - Comparative studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40967921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.atitle=A+Comparative+Study+of+Host+Cell+Responses+to+M._tuberculosis+PE_PGRS+Proteins&rft.au=Singh%2C+P+P&rft.aulast=Singh&rft.aufirst=P&rft.date=2008-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluating Old and New TB Vaccines: The Search for Correlates of Protection and a New Potency Assay T2 - Third International Conference on TB Vaccines for the World (TBV 2008) AN - 40964545; 4869236 JF - Third International Conference on TB Vaccines for the World (TBV 2008) AU - Parra, M Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40964545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.atitle=Evaluating+Old+and+New+TB+Vaccines%3A+The+Search+for+Correlates+of+Protection+and+a+New+Potency+Assay&rft.au=Parra%2C+M&rft.aulast=Parra&rft.aufirst=M&rft.date=2008-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Effectiveness of New Recombinant Modified Vaccinia Ankara Vaccines Against Tuberculosis T2 - Third International Conference on TB Vaccines for the World (TBV 2008) AN - 40964505; 4869234 JF - Third International Conference on TB Vaccines for the World (TBV 2008) AU - Kolibab, K Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 KW - Turkey, Ankara KW - Vaccines KW - Tuberculosis KW - Vaccinia KW - Disease control KW - Recombinants KW - Mycobacterium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40964505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.atitle=Characterization+of+the+Effectiveness+of+New+Recombinant+Modified+Vaccinia+Ankara+Vaccines+Against+Tuberculosis&rft.au=Kolibab%2C+K&rft.aulast=Kolibab&rft.aufirst=K&rft.date=2008-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post-infection Vaccines, are they Safe? T2 - Third International Conference on TB Vaccines for the World (TBV 2008) AN - 40960393; 4869193 JF - Third International Conference on TB Vaccines for the World (TBV 2008) AU - Morris, Sheldon Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40960393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.atitle=Post-infection+Vaccines%2C+are+they+Safe%3F&rft.au=Morris%2C+Sheldon&rft.aulast=Morris&rft.aufirst=Sheldon&rft.date=2008-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Quantitative determination of thallium binding to ferric hexacyanoferrate: Prussian blue. AN - 70386619; 18226478 AB - Ferric hexacyanoferrate, (Fe(4)(III)[Fe(II)(CN)(6)](3)), also known as insoluble Prussian blue (PB), is the active pharmaceutical ingredient (API) of Radiogardase which is the first approved drug product (DP) for treatment of thallium and radiocesium poisoning. The aim of this study is (1) to determine the in vitro thallium binding capacity and binding rates of insoluble PB; and (2) to evaluate the effect of physiological pH conditions, PB particle size and storage conditions on the binding to PB. Experimental pH levels from 1.0 to 7.5 were used to cover the range of pH levels that PB may encounter when traveling through the gastrointestinal (GI) tract in humans. Measurements of thallium binding were made between 1 and 24h, to cover gastric and intestinal tract residence time. PB was found to have a binding capacity of approximately 1400 mg/g at pH 7.5. When the pH decreased, the binding decreased as well. The results indicated that the hydration state of PB influences the thallium binding process. It was also found that there exits a direct correlation between the moisture loss in PB and the thallium binding rate constant. The PB with 17 mol of water had a binding rate constant of 0.52, which was reduced to 0.32 when PB was dehydrated to 2.5 mol of water. Significant differences were observed in both binding capacity and binding rate constant among PB fractions with different particle size ranges. PB fraction with particle size of 220-1000 microm had a binding rate constant of 0.43, which increased to 0.64 when the particle size was reduced to 32-90 microm. Batch-to-batch variation in thallium binding was also observed among the APIs and the DPs and this was related to particle size and hydration state. These findings can be utilized to evaluate and predict drug product quality under certain manufacturing and dry storage conditions. JF - International journal of pharmaceutics AU - Yang, Yongsheng AU - Faustino, Patrick J AU - Progar, Joseph J AU - Brownell, Charles R AU - Sadrieh, Nakissa AU - May, Joan C AU - Leutzinger, Eldon AU - Place, David A AU - Duffy, Eric P AU - Yu, Lawrence X AU - Khan, Mansoor A AU - Lyon, Robbe C AD - Food and Drug Administration, Center for Drug Evaluation and Research, Office of Testing and Research, Division of Product Quality Research, Silver Spring, MD 20993, USA. Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 SP - 187 EP - 194 VL - 353 IS - 1-2 SN - 0378-5173, 0378-5173 KW - Ferrocyanides KW - 0 KW - Thallium KW - AD84R52XLF KW - ferric ferrocyanide KW - TLE294X33A KW - Index Medicus KW - Particle Size KW - Hydrogen-Ion Concentration KW - Ferrocyanides -- chemistry KW - Thallium -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70386619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+pharmaceutics&rft.atitle=Quantitative+determination+of+thallium+binding+to+ferric+hexacyanoferrate%3A+Prussian+blue.&rft.au=Yang%2C+Yongsheng%3BFaustino%2C+Patrick+J%3BProgar%2C+Joseph+J%3BBrownell%2C+Charles+R%3BSadrieh%2C+Nakissa%3BMay%2C+Joan+C%3BLeutzinger%2C+Eldon%3BPlace%2C+David+A%3BDuffy%2C+Eric+P%3BYu%2C+Lawrence+X%3BKhan%2C+Mansoor+A%3BLyon%2C+Robbe+C&rft.aulast=Yang&rft.aufirst=Yongsheng&rft.date=2008-04-02&rft.volume=353&rft.issue=1-2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=International+journal+of+pharmaceutics&rft.issn=03785173&rft_id=info:doi/10.1016%2Fj.ijpharm.2007.11.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-23 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijpharm.2007.11.031 ER - TY - CPAPER T1 - Impact of the 1998 Renal Guidance on Recent New Drug Application Submissions T2 - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AN - 40913976; 4847407 JF - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AU - Huang, S AU - Abraham, S AU - Apparaju, S AU - Atkinson Jr, A AU - Burckart, G AU - Lee, C AU - Roy, K AU - Strong, J AU - Xiao, S AU - Wu, T. AU - Zhang, L AU - Zhang, Y AU - Lesko, L Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 KW - Drugs KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40913976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.atitle=Impact+of+the+1998+Renal+Guidance+on+Recent+New+Drug+Application+Submissions&rft.au=Huang%2C+S%3BAbraham%2C+S%3BApparaju%2C+S%3BAtkinson+Jr%2C+A%3BBurckart%2C+G%3BLee%2C+C%3BRoy%2C+K%3BStrong%2C+J%3BXiao%2C+S%3BWu%2C+T.%3BZhang%2C+L%3BZhang%2C+Y%3BLesko%2C+L&rft.aulast=Huang&rft.aufirst=S&rft.date=2008-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2008/2008_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - QT Prolongation Potential for New Molecular Entity Drugs Approved by FDA, 2003-2006: Labeling Review T2 - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AN - 40911715; 4847279 JF - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AU - Gevorkian, N AU - Sharma, P AU - Pinnow, E AU - Parekh, A Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 KW - Reviews KW - Drugs KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40911715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.atitle=QT+Prolongation+Potential+for+New+Molecular+Entity+Drugs+Approved+by+FDA%2C+2003-2006%3A+Labeling+Review&rft.au=Gevorkian%2C+N%3BSharma%2C+P%3BPinnow%2C+E%3BParekh%2C+A&rft.aulast=Gevorkian&rft.aufirst=N&rft.date=2008-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2008/2008_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inclusion of Subpopulations in Early Phase Clinical Trials Submitted to the FDA: A Review of NMES Approved in 2006 T2 - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AN - 40911510; 4847412 JF - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AU - Pinnow, E AU - Parekh, A AU - Sharma, P AU - Gevorkian, N AU - Uhl, K Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 KW - Clinical trials KW - Reviews KW - Subpopulations KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40911510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.atitle=Inclusion+of+Subpopulations+in+Early+Phase+Clinical+Trials+Submitted+to+the+FDA%3A+A+Review+of+NMES+Approved+in+2006&rft.au=Pinnow%2C+E%3BParekh%2C+A%3BSharma%2C+P%3BGevorkian%2C+N%3BUhl%2C+K&rft.aulast=Pinnow&rft.aufirst=E&rft.date=2008-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2008/2008_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Effect of p53 genotype on gene expression profiles in murine liver AN - 19800395; 8254809 AB - The tumor suppressor protein p53 is a key regulatory element in the cell and is regarded as the ''guardian of the genome''. Much of the present knowledge of p53 function has come from studies of transgenic mice in which the p53 gene has undergone a targeted deletion. In order to provide additional insight into the impact on the cellular regulatory networks associated with the loss of this gene, microarray technology was utilized to assess gene expression in tissues from both the p53 super(-) super(/) super(-) and p53 super(+) super(/) super(-) mice. Six male mice from each genotype (p53 super(+) super(/) super(+), p53 super(+) super(/) super(-), and p53 super(-) super(/) super(-)) were humanely killed and the tissues processed for microarray analysis. The initial studies have been performed in the liver for which the Dunnett test revealed 1406 genes to be differentially expressed between p53 super(+) super(/) super(+) and p53 super(+) super(/) super(-) or between p53 super(+) super(/) super(+) and p53 super(-) super(/) super(-) at the level of p approximately equal to 0.05. Both genes with increased expression and decreased expression were identified in p53 super(+) super(/) super(-) and in p53 super(-) super(/) super(-) mice. Most notable in the gene list derived from the p53 super(+) super(/) super(-) mice was the significant reduction in p53 mRNA. In the p53 super(-) super(/) super(-) mice, not only was there reduced expression of the p53 genes on the array, but genes associated with DNA repair, apoptosis, and cell proliferation were differentially expressed, as expected. However, altered expression was noted for many genes in the Cdc42-GTPase pathways that influence cell proliferation. This may indicate that alternate pathways are brought into play in the unperturbed liver when loss or reduction in p53 levels occurs. JF - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis AU - Morris, S M AU - Akerman, G S AU - Desai, V G AU - Tsai, Ca AU - Tolleson, W H AU - Melchior, W B AU - Lin, C J AU - Fuscoe, J C AU - Casciano, DA AU - Chen, J J AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States, suzanne.morris@fda.hhs.gov Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 SP - 54 EP - 73 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 640 IS - 1-2 SN - 1386-1964, 1386-1964 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Genomes KW - Tumor suppressor genes KW - Molecular modelling KW - Play KW - Apoptosis KW - Regulatory sequences KW - Genotypes KW - DNA repair KW - Transgenic mice KW - p53 protein KW - Mutagenesis KW - Gene expression KW - Gene deletion KW - Liver KW - Cell proliferation KW - W 30925:Genetic Engineering KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19800395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.atitle=Effect+of+p53+genotype+on+gene+expression+profiles+in+murine+liver&rft.au=Morris%2C+S+M%3BAkerman%2C+G+S%3BDesai%2C+V+G%3BTsai%2C+Ca%3BTolleson%2C+W+H%3BMelchior%2C+W+B%3BLin%2C+C+J%3BFuscoe%2C+J+C%3BCasciano%2C+DA%3BChen%2C+J+J&rft.aulast=Morris&rft.aufirst=S&rft.date=2008-04-02&rft.volume=640&rft.issue=1-2&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.issn=13861964&rft_id=info:doi/10.1016%2Fj.mrfmmm.2007.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Tumor suppressor genes; Apoptosis; Play; Regulatory sequences; Genotypes; Transgenic mice; DNA repair; Mutagenesis; p53 protein; Gene expression; Gene deletion; Liver; Cell proliferation DO - http://dx.doi.org/10.1016/j.mrfmmm.2007.12.004 ER - TY - JOUR T1 - Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine. AN - 71637716; 18441258 AB - Immunohistochemical studies for kidney injury molecule-1 (Kim-1), renal papillary antigen-1 (RPA-1), and renal papillary antigen-2 (RPA-2) were conducted to explore their relationship to inducible nitric oxide synthase (iNOS) and nitrotyrosine expression. Male Sprague-Dawley rats were exposed to gentamicin (100 mg/kg/day Gen, sc, for 3 days), mercury (0.25 mg Hg/kg, iv, single dose), or chromium (5 mg Cr/kg, sc, single dose) and kidney tissue was examined 24 hours or 72 hours after the last dose of the nephrotoxicant. Another group of kidneys was evaluated 24 hours after rats were administered 3 daily doses (50, 100, 150, 200, or 300 mg/kg/day) of Gen. Gen- and Cr-treated rats exhibited increased immunoreactivity of Kim-1, RPA-1, and RPA-2 largely in the S1/S2 segments and to a lesser extent in the S3 segments of the proximal tubule of the kidney, whereas Hg-treated rats showed increased immunoreactivity of Kim-1, RPA-1, and RPA-2 in the S3 segments. Up-regulation of Kim-1, RPA-1, and RPA-2 expression correlated with injured tubular epithelial cells and also correlated with immunoreactivity of iNOS and nitrotyrosine. It is possible that iNOS activation with nitrotyrosine production in injured nephron segments may be involved in the induction of Kim-1, RPA-1, and RPA-2 following exposure to nephrotoxicants. JF - Toxicologic pathology AU - Zhang, Jun AU - Brown, Ronald P AU - Shaw, Martin AU - Vaidya, Vishal S AU - Zhou, Yuzhao AU - Espandiari, Parvaneh AU - Sadrieh, Nakissa AU - Stratmeyer, Melvin AU - Keenan, Joe AU - Kilty, Cormac G AU - Bonventre, Joseph V AU - Goering, Peter L AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA. jun.zhang@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 397 EP - 409 VL - 36 IS - 3 KW - Antigens KW - 0 KW - Biomarkers KW - Cell Adhesion Molecules KW - Gentamicins KW - Havcr1protein, rat KW - Xenobiotics KW - renal tubular antigen KW - Peroxynitrous Acid KW - 14691-52-2 KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Mercuric Chloride KW - 53GH7MZT1R KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Nos2 protein, rat KW - Potassium Dichromate KW - T4423S18FM KW - Index Medicus KW - Peroxynitrous Acid -- metabolism KW - Animals KW - Dose-Response Relationship, Drug KW - Fluorescent Antibody Technique, Indirect KW - Disease Models, Animal KW - Kidney Tubules, Proximal -- pathology KW - Rats KW - Gentamicins -- toxicity KW - Rats, Sprague-Dawley KW - Potassium Dichromate -- toxicity KW - Kidney Tubules, Proximal -- metabolism KW - Apoptosis -- drug effects KW - Biomarkers -- metabolism KW - Kidney Tubules, Proximal -- drug effects KW - Up-Regulation KW - Mercuric Chloride -- toxicity KW - Immunohistochemistry KW - Male KW - Immunoenzyme Techniques KW - Kidney -- metabolism KW - Antigens -- metabolism KW - Kidney -- pathology KW - Kidney -- drug effects KW - Cell Adhesion Molecules -- metabolism KW - Nitric Oxide Synthase Type II -- metabolism KW - Xenobiotics -- toxicity KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71637716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Immunolocalization+of+Kim-1%2C+RPA-1%2C+and+RPA-2+in+kidney+of+gentamicin-%2C+mercury-%2C+or+chromium-treated+rats%3A+relationship+to+renal+distributions+of+iNOS+and+nitrotyrosine.&rft.au=Zhang%2C+Jun%3BBrown%2C+Ronald+P%3BShaw%2C+Martin%3BVaidya%2C+Vishal+S%3BZhou%2C+Yuzhao%3BEspandiari%2C+Parvaneh%3BSadrieh%2C+Nakissa%3BStratmeyer%2C+Melvin%3BKeenan%2C+Joe%3BKilty%2C+Cormac+G%3BBonventre%2C+Joseph+V%3BGoering%2C+Peter+L&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2008-04-01&rft.volume=36&rft.issue=3&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308315832 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-05 N1 - Date created - 2008-06-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Surg Pathol. 2007 Mar;31(3):371-81 [17325478] Toxicol Pathol. 2007 Feb;35(2):270-5 [17366321] Expert Opin Drug Saf. 2007 Mar;6(2):207-15 [17367267] J Pathol. 2007 Jun;212(2):209-17 [17471468] Toxicol Sci. 2007 Oct;99(2):637-48 [17636248] Toxicol Sci. 2008 Jan;101(1):159-70 [17934191] Drug Metab Rev. 1999 Nov;31(4):971-97 [10575556] Kidney Int. 2000 May;57(5):1968-72 [10792615] Mol Cell Biochem. 2001 Jun;222(1-2):149-58 [11678597] Kidney Int. 2002 Mar;61(3):855-61 [11849438] Kidney Int. 2002 Jul;62(1):237-44 [12081583] Nephron. 2002 Sep;92(1):133-41 [12187096] Diabetes. 2002 Nov;51(11):3274-82 [12401719] Am J Physiol Renal Physiol. 2002 Dec;283(6):F1326-36 [12388382] Antioxid Redox Signal. 2002 Dec;4(6):915-24 [12573140] J Biol Chem. 2003 Jul 18;278(29):27256-66 [12682064] Life Sci. 2003 Oct 3;73(20):2543-56 [12967679] Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63 [14600030] Environ Health Perspect. 2004 Mar;112(4):465-79 [15033597] Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4003-8 [15020765] Cancer. 1977 Apr;39(4):1362-71 [851939] Ren Physiol. 1987;10(1):54-64 [3685614] J Pharmacol Exp Ther. 1988 Mar;244(3):1081-5 [3252023] Cancer Chemother Pharmacol. 1989;25(1):1-9 [2686850] Exp Pathol. 1990;38(4):231-9 [2387365] Am J Physiol. 1994 Nov;267(5 Pt 2):F748-57 [7526707] Arch Toxicol. 1996;71(1-2):80-92 [9010589] Hypertension. 1997 Oct;30(4):948-52 [9336398] J Biol Chem. 1998 Feb 13;273(7):4135-42 [9461608] Toxicol Pathol. 1998 Jan-Feb;26(1):92-103 [9502391] Kidney Int. 1998 Jun;53(6):1642-6 [9607195] Ind Health. 1998 Oct;36(4):324-30 [9810145] Am J Physiol. 1999 Jun;276(6 Pt 2):F874-81 [10362776] Am J Physiol. 1999 Jul;277(1 Pt 2):F33-40 [10409295] Arch Toxicol. 1999 Jun-Jul;73(4-5):233-45 [10463389] Toxicology. 2005 Feb 14;207(2):169-77 [15596248] BMC Nephrol. 2005;6:4 [15854231] J Nephrol. 2005 Sep-Oct;18(5):548-52 [16299680] Am J Physiol Renal Physiol. 2006 Feb;290(2):F517-29 [16174863] J Pharmacol Exp Ther. 2006 Mar;316(3):1038-46 [16306274] Toxicol Pathol. 2006;34(2):152-63 [16537294] Nat Rev Cancer. 2006 Jul;6(7):521-34 [16794635] Am J Physiol Renal Physiol. 2006 Aug;291(2):F456-64 [16467126] Expert Opin Drug Metab Toxicol. 2006 Oct;2(5):697-713 [17014390] Cancer Biomark. 2005;1(1):69-74 [17192033] Am J Physiol Renal Physiol. 2007 Jan;292(1):F313-20 [16896183] Physiol Rev. 2007 Jan;87(1):315-424 [17237348] Kidney Int. 2007 Mar;71(5):417-24 [17213874] Kidney Int. 2008 Mar;73(5):608-14 [18160964] Comment In: Toxicol Pathol. 2008 Oct;36(6):890; author reply 891-3 [18701423] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623308315832 ER - TY - JOUR T1 - Occupational risks for idiopathic pulmonary fibrosis mortality in the United States. AN - 70796109; 18507288 AB - Metal and wood dust exposures have been identified as possible occupational risk factors for idiopathic pulmonary fibrosis (IPF). We analyzed mortality data using ICD-10 code J84.1--"Other interstitial pulmonary diseases with fibrosis," derived age-adjusted mortality rates for 1999-2003, and assessed occupational risks for 1999, by calculating proportionate mortality ratios (PMRs) and mortality odds ratios (MORs) using a matched case-control approach. We identified 84,010 IPF deaths, with an age-adjusted mortality rate of 75.7 deaths/million. Mortality rates were highest among males, whites, and those aged 85 and older. Three industry categories with potential occupational exposures recognized as risk factors for IPF were identified: "Wood buildings and mobile homes" (PMR = 4.5, 95% confidence interval (CI) 1.2-11.6 and MOR = 5.3, 95% CI 1.2-23.8), "Metal mining" (PMR = 2.4, 95% CI 1.3-4.0 and MOR = 2.2, 95% CI 1.1-4.4), and "Fabricated structural metal products" (PMR = 1.9, 95% CI 1.1-3.1 and MOR = 1.7, 95% CI 1.0-3.1). Workers in these industry categories may benefit from toxicological studies and improved surveillance for this disease. JF - International journal of occupational and environmental health AU - Pinheiro, Germania A AU - Antao, Vinicius C AU - Wood, John M AU - Wassell, James T AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. germania.pinheiro@yahoo.com PY - 2008 SP - 117 EP - 123 VL - 14 IS - 2 SN - 1077-3525, 1077-3525 KW - Dust KW - 0 KW - Metals KW - Index Medicus KW - Humans KW - Wood KW - Aged KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Industry KW - Occupational Exposure KW - Pulmonary Fibrosis -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70796109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+and+environmental+health&rft.atitle=Occupational+risks+for+idiopathic+pulmonary+fibrosis+mortality+in+the+United+States.&rft.au=Pinheiro%2C+Germania+A%3BAntao%2C+Vinicius+C%3BWood%2C+John+M%3BWassell%2C+James+T&rft.aulast=Pinheiro&rft.aufirst=Germania&rft.date=2008-04-01&rft.volume=14&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+and+environmental+health&rft.issn=10773525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular epidemiological analysis and microbial source tracking of Salmonella enterica serovars in a preharvest turkey production environment. AN - 70500922; 18361686 AB - Epidemiological studies were conducted to source track and delineate horizontal transmission pathways of Salmonella serovars in a turkey production environment. Salmonella enterica serovar Heidelberg (n = 111), Salmonella Senftenberg (n = 14), Salmonella Muenster (n = 10), unidentifiable "roughs" (n = 5), Salmonella Anatum (n = 3), and Salmonella Worthington (n = 2) were isolated from the birds' cecal and crop contents, litter, environmental swabs, drinkers, and feed samples. These strains (n = 145) were analyzed for their antimicrobial susceptibility profiles and the bacterial horizontal transmission pathways were tracked by XbaI-digested pulsed-field gel electrophoresis (PFGE) macrorestriction profiles. Nearly 79% of the strains were resistant to one or more antimicrobials, while 44% of the strains were resistant to two to six antimicrobials. Nearly 21% of the strains were susceptible to all of the antimicrobials tested. Twenty-seven distinct PFGE fingerprint profiles (90-95% similarity) were observed among 110 Salmonella Heidelberg strains (one strain was untypeable), and 13 of the 27 profiles (48%) elicited 100% similarity among the fingerprint patterns. The prevalence of Salmonella Heidelberg strains at weeks 2 (n = 20), 10 (n = 20), and 18 (n = 70) among the sampled pens suggested cross-colonization among pens during the 20-week production cycle. Salmonella Heidelberg strains were first isolated from the birds at week 2, and identical fingerprint profiles of this serovar were subsequently isolated from birds within the same pen; birds in other pens; and litter, air, and swab samples at weeks 10 and 18, suggesting possible horizontal transmission of this serovar across the production facility during the grow-out period. JF - Foodborne pathogens and disease AU - Nayak, Rajesh AU - Stewart-King, Tabitha AD - U.S. Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, Jefferson, Arkansas 72079, USA. Rajesh.Nayak@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 115 EP - 126 VL - 5 IS - 2 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - Index Medicus KW - Phylogeny KW - Feces -- microbiology KW - Animals KW - Humans KW - Food Contamination -- analysis KW - Serotyping KW - Drug Resistance, Multiple, Bacterial KW - DNA, Bacterial -- analysis KW - Genotype KW - Food Contamination -- prevention & control KW - Food Microbiology KW - Molecular Epidemiology KW - Electrophoresis, Gel, Pulsed-Field KW - Colony Count, Microbial KW - Microbial Sensitivity Tests KW - Environmental Microbiology KW - Salmonella enterica -- isolation & purification KW - Turkeys -- microbiology KW - Consumer Product Safety KW - Drug Resistance, Bacterial KW - Salmonella enterica -- genetics KW - Anti-Bacterial Agents -- pharmacology KW - Salmonella enterica -- classification KW - Salmonella enterica -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70500922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Foodborne+pathogens+and+disease&rft.atitle=Molecular+epidemiological+analysis+and+microbial+source+tracking+of+Salmonella+enterica+serovars+in+a+preharvest+turkey+production+environment.&rft.au=Nayak%2C+Rajesh%3BStewart-King%2C+Tabitha&rft.aulast=Nayak&rft.aufirst=Rajesh&rft.date=2008-04-01&rft.volume=5&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Foodborne+pathogens+and+disease&rft.issn=1556-7125&rft_id=info:doi/10.1089%2Ffpd.2007.0029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-11 N1 - Date created - 2008-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/fpd.2007.0029 ER - TY - JOUR T1 - Captan exposure and evaluation of a pesticide exposure algorithm among orchard pesticide applicators in the Agricultural Health Study. AN - 70493064; 18326518 AB - Pesticide exposure assessment in the Agricultural Health Study (AHS) has relied upon two exposure metrics: lifetime exposure days and intensity-weighted lifetime exposure days, the latter incorporating an intensity score computed from a questionnaire-based algorithm. We evaluated this algorithm using actual fungicide exposure measurements from AHS private orchard applicators. Captan was selected as a marker of fungicide exposure. Seventy-four applicators from North Carolina and Iowa growing apples and/or peaches were sampled on 2 days they applied captan in 2002 and 2003. Personal air, hand rinse, 10 dermal patches, a pre-application first-morning urine and a subsequent 24-h urine sample were collected from each applicator per day. Environmental samples were analyzed for captan, and urine samples were analyzed for cis-1,2,3,6-tetrahydrophthalimide (THPI). Task and personal protective equipment information needed to compute an individual's algorithm score was also collected. Differences in analyte detection frequency were tested in a repeated logistic regression model. Mixed-effects models using maximum-likelihood estimation were employed to estimate geometric mean exposures and to evaluate the measured exposure data against the algorithm. In general, captan and THPI were detected significantly more frequently in environmental and urine samples collected from applicators who used air blast sprayers as compared to those who hand sprayed. The AHS pesticide exposure intensity algorithm, while significantly or marginally predictive of thigh and forearm captan exposure, respectively, did not predict air, hand rinse or urinary THPI exposures. The algorithm's lack of fit with some exposure measures among orchard fungicide applicators may be due in part to the assignment of equal exposure weights to air blast and hand spray application methods in the current algorithm. Some modification of the algorithm is suggested by these results. JF - The Annals of occupational hygiene AU - Hines, Cynthia J AU - Deddens, James A AU - Jaycox, Larry B AU - Andrews, Ronnee N AU - Striley, Cynthia A F AU - Alavanja, Michael C R AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway R-14, Cincinnati, OH 45226, USA. chines@cde.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 153 EP - 166 VL - 52 IS - 3 KW - Fungicides, Industrial KW - 0 KW - Captan KW - EOL5G26Q9F KW - Index Medicus KW - Humans KW - Algorithms KW - Fruit KW - Models, Biological KW - Male KW - Female KW - Environmental Monitoring -- methods KW - Agriculture KW - Fungicides, Industrial -- analysis KW - Fungicides, Industrial -- administration & dosage KW - Captan -- administration & dosage KW - Occupational Exposure -- analysis KW - Captan -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70493064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Captan+exposure+and+evaluation+of+a+pesticide+exposure+algorithm+among+orchard+pesticide+applicators+in+the+Agricultural+Health+Study.&rft.au=Hines%2C+Cynthia+J%3BDeddens%2C+James+A%3BJaycox%2C+Larry+B%3BAndrews%2C+Ronnee+N%3BStriley%2C+Cynthia+A+F%3BAlavanja%2C+Michael+C+R&rft.aulast=Hines&rft.aufirst=Cynthia&rft.date=2008-04-01&rft.volume=52&rft.issue=3&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmen001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/men001 ER - TY - JOUR T1 - Onset of acute myocardial infarction after use of non-steroidal anti-inflammatory drugs. AN - 70468729; 18302311 AB - To examine the association between cyclooxygenase-2 (COX-2) selective and traditional nonsteroidal anti-inflammatory drugs (NSAIDs) and incident acute myocardial infarction (AMI), and to address unanswered questions regarding the contour of risk over time. A cohort of new NSAID users aged 40-84 years was followed for the occurrence of first AMI. Data were collected within the General Practice Research Database (GPRD) from 1 January 1997 to 31 December 2004. The study population included 1185 AMI events (889 probable and 296 possible) from a cohort of 283 136 patients. After adjustment for demographic and cardiovascular risk factors, the hazard ratio (HR) for AMI was significantly increased for both coxib (2.11, 95% confidence interval (CI) 1.04-4.26) and non-coxib (2.24, 95%CI 1.13-4.42) COX-2 selective NSAIDs when compared to remote exposure to NSAIDs, but was not increased for traditional NSAIDs. Stratifying exposure into the first month of use versus use beyond 1 month, the risk of AMI was increased during the first month of COX-2 selective NSAIDs use, but not later (3.43, 95%CI 1.66-7.07 and 1.88, 95%CI 0.82-4.31, respectively p-value for interaction = 0.6). The results suggest that the use of coxib and non-coxib COX-2 selective NSAIDs was associated with an elevated risk of AMI within the first month of exposure. Recent past exposure to NSAID was not associated with a similar increase in risk. JF - Pharmacoepidemiology and drug safety AU - Hammad, Tarek A AU - Graham, David J AU - Staffa, Judy A AU - Kornegay, Cynthia J AU - Dal Pan, Gerald J AD - Office of Surveillance and Epidemiology, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. tarek.hammad@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 315 EP - 321 VL - 17 IS - 4 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Index Medicus KW - Medical Records Systems, Computerized KW - Humans KW - Aged KW - Pharmacoepidemiology KW - United Kingdom -- epidemiology KW - Social Class KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Cohort Studies KW - Confidence Intervals KW - Middle Aged KW - Female KW - Male KW - Myocardial Infarction -- chemically induced KW - Cyclooxygenase 2 Inhibitors -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Myocardial Infarction -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70468729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Onset+of+acute+myocardial+infarction+after+use+of+non-steroidal+anti-inflammatory+drugs.&rft.au=Hammad%2C+Tarek+A%3BGraham%2C+David+J%3BStaffa%2C+Judy+A%3BKornegay%2C+Cynthia+J%3BDal+Pan%2C+Gerald+J&rft.aulast=Hammad&rft.aufirst=Tarek&rft.date=2008-04-01&rft.volume=17&rft.issue=4&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=1099-1557&rft_id=info:doi/10.1002%2Fpds.1560 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-17 N1 - Date created - 2008-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pds.1560 ER - TY - JOUR T1 - Indoor air quality in prisons before and after implementation of a smoking ban law. AN - 70451091; 18285386 AB - To ascertain whether a new indoor smoking ban law in North Carolina correctional facilities was successfully implemented and whether the indoor air quality has improved as a result. Before the law came into effect, we tested the air quality of 22 dormitory and common areas within six North Carolina prisons using standard protocols for testing particulate matter. We measured particulate matter 2.5 microm in diameter (PM(2.5)) using state of the art TSI SidePak monitors. After the law went into effect, the same locations within each prison were tested again. Written inmate surveys were also conducted at two prisons, one with partial smoking ban (indoors only) and one with a total smoking ban (indoors and outdoors). The findings indicate that, on average, levels of respirable suspended particulates (RSPs), an accepted marker for secondhand smoke (SHS) levels, decreased 77% in these prisons after the law took effect compared to levels obtained before ban implementation. Several areas were tobacco-free before the implementation of this ban. In those areas no significant decreases in RSPs were noted. Laws banning tobacco use in correctional facilities can significantly reduce indoor SHS exposure among inmates, visitors and staff and potentially lead to reduced use. To date, 24 US states have enacted 100% smoke-free correctional facility policies for all indoor areas even though inmates and staff have much higher tobacco use prevalence rates than the general population. With an estimated nine million people incarcerated worldwide, prison smoking bans could have a substantial impact in terms of health outcomes and long-term costs if they can effectively reduce exposure to secondhand smoke. JF - Tobacco control AU - Proescholdbell, S K AU - Foley, K L AU - Johnson, J AU - Malek, S H AD - Tobacco Prevention and Control Branch, Division of Public Health, North Carolina Department of Health and Human Services, 1932 Mail Service Center, Raleigh, NC 27699-1932, USA. scott.proescholdbell@ncmail.net Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 123 EP - 127 VL - 17 IS - 2 KW - Particulate Matter KW - 0 KW - Tobacco Smoke Pollution KW - Index Medicus KW - Humans KW - Adult KW - North Carolina -- epidemiology KW - Health Policy KW - Particulate Matter -- analysis KW - Air Pollution, Indoor -- analysis KW - Tobacco Smoke Pollution -- legislation & jurisprudence KW - Air Pollution, Indoor -- legislation & jurisprudence KW - Tobacco Smoke Pollution -- analysis KW - Prisons -- trends KW - Prisons -- legislation & jurisprudence KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70451091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+control&rft.atitle=Indoor+air+quality+in+prisons+before+and+after+implementation+of+a+smoking+ban+law.&rft.au=Proescholdbell%2C+S+K%3BFoley%2C+K+L%3BJohnson%2C+J%3BMalek%2C+S+H&rft.aulast=Proescholdbell&rft.aufirst=S&rft.date=2008-04-01&rft.volume=17&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Tobacco+control&rft.issn=1468-3318&rft_id=info:doi/10.1136%2Ftc.2007.022038 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-15 N1 - Date created - 2008-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/tc.2007.022038 ER - TY - JOUR T1 - Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database. AN - 70431282; 18363538 AB - We describe a 71-year-old man who had received warfarin 7.5 mg/day for 5 years for atrial fibrillation, which had maintained his international normalized ratio (INR) within a narrow range of 2.5-3.2. During this 5-year period, he had also been treating himself with the supplement glucosamine hydrochloride 500 mg-chondroitin sulfate 400 mg twice/day for arthritis. The patient then increased his dosage of glucosamine to 1500 mg and chondroitin to 1200 mg twice/day; his INR previous to this change was 2.3. Approximately 3 weeks later, his INR increased to 3.9. His supplement dosage was reduced to glucosamine 750 mg-chondroitin 600 mg/day; a repeat INR done 16 days later was 4.7. The supplement was then stopped, and his warfarin schedule was changed to 7.5 mg every other day alternating with 3.75 mg every other day. Sixteen days later, his INR was 2.6. This case report suggests that a potential interaction exists between warfarin and glucosamine that is associated with an increase in the INR. We therefore performed a pharmacovigilance survey of spontaneously reported adverse events in warfarin-treated patients concomitantly exposed to glucosamine, glucosamine-chondroitin sulfate, or chondroitin sulfate and present a literature review of this apparent drug-drug interaction. Using the United States Food and Drug Administration (FDA) MedWatch database, 20 reports of glucosamine or glucosamine-chondroitin sulfate use with warfarin associated with altered coagulation (manifested by increased INR, or increased bleeding or bruising) were identified. In some cases, a decrease in the supplement dosage was followed by a return of the INR to the previous therapeutic range. Similarly, a decrease in warfarin dosage was followed by a decrease in INR in one patient who received long-term warfarin therapy. One report described an intraventricular bleed and subdural hematoma, which resulted in a persistent vegetative state. The World Health Organization (WHO) adverse drug reactions database documented 21 spontaneous reports of increased INR associated with glucosamine use, 17 of which resolved when glucosamine was stopped. We located one published case report of concomitant use of glucosamine-chondroitin sulfate potentiating the effect of warfarin. In aggregate, the reports from the FDA and WHO, the published case report, and our case report suggest that the use of warfarin and glucosamine may lead to an increased INR. Patients should be advised that the use of the two products may cause an increase in INR, and they should inform their health care provider if they consume glucosamine. More information is necessary to define this interaction. JF - Pharmacotherapy AU - Knudsen, James F AU - Sokol, Gerald H AD - Division of Neurology and Psychiatry Drug Products, Office of Drug Evaluation I, United States Food and Drug Administration, Silver Spring, MD 20993-0002, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 540 EP - 548 VL - 28 IS - 4 SN - 0277-0008, 0277-0008 KW - Anticoagulants KW - 0 KW - Drug Combinations KW - Warfarin KW - 5Q7ZVV76EI KW - Chondroitin Sulfates KW - 9007-28-7 KW - Glucosamine KW - N08U5BOQ1K KW - Index Medicus KW - Drug Interactions KW - Chondroitin Sulfates -- administration & dosage KW - Aged, 80 and over KW - Humans KW - International Normalized Ratio KW - Adult KW - Aged KW - Middle Aged KW - Dietary Supplements KW - Male KW - Female KW - Anticoagulants -- adverse effects KW - Warfarin -- adverse effects KW - Warfarin -- administration & dosage KW - Glucosamine -- pharmacology KW - Anticoagulants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70431282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Potential+glucosamine-warfarin+interaction+resulting+in+increased+international+normalized+ratio%3A+case+report+and+review+of+the+literature+and+MedWatch+database.&rft.au=Knudsen%2C+James+F%3BSokol%2C+Gerald+H&rft.aulast=Knudsen&rft.aufirst=James&rft.date=2008-04-01&rft.volume=28&rft.issue=4&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/10.1592%2Fphco.28.4.540 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1592/phco.28.4.540 ER - TY - JOUR T1 - Fetal ultrasound: mechanical effects. AN - 70419848; 18359910 AB - In this discussion, any biological effect of ultrasound that is accompanied by temperature increments less than 1 degrees C above normal physiologic levels is called a mechanical effect. However, one should keep in mind that the term mechanical effect also includes processes that are not of a mechanical nature but arise secondary to mechanical interaction between ultrasound and tissues, such as chemical reactions initiated by free oxygen species generated during cavitation and sonoluminescence. Investigations with laboratory animals have documented that pulsed ultrasound can produce damage to biological tissues in vivo through nonthermal mechanisms. The acoustic output used to induce these adverse bio-effects is considerably greater than the output of diagnostic devices when gas bodies are not present. However, low-intensity pulsed ultrasound is used clinically to accelerate the bone fracture repair process and induce healing of nonunions in humans. Low-intensity pulsed ultrasound also has been shown to enhance repair of soft tissue damage and accelerate nerve regeneration in animal models. Although such exposures to low intensity do not appear to cause damage to exposed tissues, they do raise questions about the acoustic threshold that might induce potentially adverse developmental effects in the fetus. To date, bioeffects studies in humans do not substantiate a causal relationship between diagnostic ultrasound exposure during pregnancy and adverse biological effects to the fetus. However, the epidemiologic studies were conducted with commercially available devices predating 1992, having outputs not exceeding a derated spatial-peak temporal-average intensity (ISPTA.3) of 94 mW/cm2. Current limits in the United States allow an ISPTA.3 of 720 mW/cm2 for obstetric modes. At the time of this report, available evidence, experimental or epidemiologic, is insufficient to conclude that there is a causal relationship between obstetric diagnostic ultrasound exposure and adverse nonthermal effects to the fetus. However, low-intensity pulsed ultrasound effects reported in humans and animal models indicate a need for further investigation of potentially adverse developmental effects. JF - Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine AU - Stratmeyer, Melvin E AU - Greenleaf, James F AU - Dalecki, Diane AU - Salvesen, Kjell A AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, 9200 Corporate Blvd, HFZ-120, Rockville, MD 20850 USA. melvin.stratmeyer@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 597 EP - 605; quiz 606-9 VL - 27 IS - 4 SN - 0278-4297, 0278-4297 KW - Index Medicus KW - Radiation Dosage KW - Animals KW - Risk Factors KW - Humans KW - Dose-Response Relationship, Radiation KW - Female KW - Risk Assessment KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Ultrasonography, Prenatal -- adverse effects KW - Fetus -- radiation effects KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70419848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+ultrasound+in+medicine+%3A+official+journal+of+the+American+Institute+of+Ultrasound+in+Medicine&rft.atitle=Fetal+ultrasound%3A+mechanical+effects.&rft.au=Stratmeyer%2C+Melvin+E%3BGreenleaf%2C+James+F%3BDalecki%2C+Diane%3BSalvesen%2C+Kjell+A&rft.aulast=Stratmeyer&rft.aufirst=Melvin&rft.date=2008-04-01&rft.volume=27&rft.issue=4&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Journal+of+ultrasound+in+medicine+%3A+official+journal+of+the+American+Institute+of+Ultrasound+in+Medicine&rft.issn=02784297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-07 N1 - Date created - 2008-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Are literature references sufficient for dose recommendations? An FDA case study of efavirenz and rifampin. AN - 70415606; 18303126 AB - One of the numerous regulatory functions of the Food and Drug Administration (FDA) is the evaluation of drug-drug interactions and the determination of appropriate dose adjustments, if necessary, to ensure the safe and effective use of medications. The FDA considers several data sources when determining the significance of drug-drug interactions. The majority of dose adjustment recommendations are based on specific drug-drug interactions studies. The FDA reviews individual patient pharmacokinetic and safety data from drug interaction studies, determines appropriate dose adjustments, and provides recommendations to update the respective product labeling. Sometimes literature references are submitted to the FDA to support dosing recommendations. Determining an appropriate dose adjustment recommendation based on literature reports is a challenge for the FDA due to the lack of individual patient pharmacokinetic or safety data from these studies. Recently, the FDA encountered a challenging regulatory situation when evaluating literature reports to determine the appropriate dose of efavirenz and rifampin. Although numerous studies were found in the literature about this combination, a dosing recommendation cannot be concluded from the reported data. This article reviews the process the FDA used to evaluate literature to support potential dose adjustments for efavirenz when coadministered with rifampin and the challenges encountered during the process. JF - Journal of clinical pharmacology AU - DiGiacinto, Jennifer L AU - Chan-Tack, Kirk M AU - Robertson, Sarah M AU - Reynolds, Kellie S AU - Struble, Kimberly A AD - Office of Clinica Pharmacology, Division IV, US Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 518 EP - 523 VL - 48 IS - 4 SN - 0091-2700, 0091-2700 KW - Anti-HIV Agents KW - 0 KW - Antitubercular Agents KW - Benzoxazines KW - efavirenz KW - JE6H2O27P8 KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - United States KW - Randomized Controlled Trials as Topic KW - Drug Interactions KW - United States Food and Drug Administration KW - Databases, Bibliographic KW - Humans KW - Reference Standards KW - Rifampin -- adverse effects KW - Antitubercular Agents -- administration & dosage KW - Anti-HIV Agents -- adverse effects KW - Anti-HIV Agents -- administration & dosage KW - Benzoxazines -- adverse effects KW - Rifampin -- administration & dosage KW - Antitubercular Agents -- adverse effects KW - Benzoxazines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70415606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Are+literature+references+sufficient+for+dose+recommendations%3F+An+FDA+case+study+of+efavirenz+and+rifampin.&rft.au=DiGiacinto%2C+Jennifer+L%3BChan-Tack%2C+Kirk+M%3BRobertson%2C+Sarah+M%3BReynolds%2C+Kellie+S%3BStruble%2C+Kimberly+A&rft.aulast=DiGiacinto&rft.aufirst=Jennifer&rft.date=2008-04-01&rft.volume=48&rft.issue=4&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270008315308 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-28 N1 - Date created - 2008-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0091270008315308 ER - TY - JOUR T1 - Substance abuse in pregnant women: making improved detection a good clinical outcome. AN - 70412221; 18349872 AB - In this issue, Gideon Koren and colleagues review the maternal and child health implications of drug-residue testing in maternal and neonatal hair and testing for drugs in meconium. Since the 1990s, these methods have been used to varying degrees in clinical practice, but recent technological advances have increased their accuracy and usability in the clinical setting. Compared with self-reported maternal use, drug-residue testing in hair and testing for drugs in meconium are more reliable methods for detecting drug and alcohol exposure during pregnancy. These methods can also provide insights into patterns of use and abuse of these substances. JF - Clinical pharmacology and therapeutics AU - Araojo, R AU - McCune, S AU - Feibus, K AD - Maternal Health Team, Pediatric and Maternal Health Staff, Office of New Drugs-Immediate Office, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 520 EP - 522 VL - 83 IS - 4 KW - Biomarkers KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Meconium -- chemistry KW - Humans KW - Hair -- chemistry KW - Biomarkers -- analysis KW - Adult KW - Infant, Newborn KW - Adolescent KW - Female KW - Pregnancy KW - Substance-Related Disorders -- diagnosis KW - Pregnancy Complications -- diagnosis KW - Prenatal Exposure Delayed Effects -- diagnosis KW - Substance Abuse Detection -- methods KW - Substance Abuse Detection -- ethics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70412221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Substance+abuse+in+pregnant+women%3A+making+improved+detection+a+good+clinical+outcome.&rft.au=Araojo%2C+R%3BMcCune%2C+S%3BFeibus%2C+K&rft.aulast=Araojo&rft.aufirst=R&rft.date=2008-04-01&rft.volume=83&rft.issue=4&rft.spage=520&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.13 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-26 N1 - Date created - 2008-03-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Clin Pharmacol Ther. 2008 Apr;83(4):631-4 [18288086] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2008.13 ER - TY - JOUR T1 - Respiratory inflammatory responses among occupants of a water-damaged office building. AN - 70383899; 18333992 AB - The National Institute for Occupational Safety and Health (NIOSH) received a request for evaluation of a water-damaged office building which housed approximately 1300 employees. Workers reported respiratory conditions that they perceived to be building related. We hypothesized that these symptoms were associated with airways inflammation. To test this hypothesis, we assessed airways inflammation in employees using exhaled breath condensate (EBC) and the fraction of exhaled nitric oxide (FENO). In September 2001, a health questionnaire was offered to all employees. Based on this questionnaire, NIOSH invited 356 symptomatic and asymptomatic employees to participate in a medical survey. In June 2002, these employees were offered questionnaire, spirometry, methacholine challenge test, allergen skin prick testing, EBC and FENO. FENO or EBC were completed by 239 participants. As smoking is highly related to the measurements that we used in this study, we included only the 207 current non-smokers in the analyses. EBC interleukin-8 (IL-8) levels, but not nitrite, were significantly higher among workers with respiratory symptoms and in the physician-diagnosed asthmatic group. Of the analyses assessed, EBC IL-8 showed the most significant relationship with a number of symptoms and physician-diagnosed asthma. Implementation of exhaled breath condensate and exhaled nitric oxide in indoor air quality problems. JF - Indoor air AU - Akpinar-Elci, M AU - Siegel, P D AU - Cox-Ganser, J M AU - Stemple, K J AU - White, S K AU - Hilsbos, K AU - Weissman, D N AD - CDC/NIOSH Division of Respiratory Diseases Studies, Morgantown, WV, USA. makpinarelci@gmail.com Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 125 EP - 130 VL - 18 IS - 2 KW - Interleukin-8 KW - 0 KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - United States KW - Exhalation KW - Humans KW - Skin Tests KW - Nitric Oxide -- metabolism KW - Workplace KW - Fungi -- growth & development KW - National Institute for Occupational Safety and Health (U.S.) KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Interleukin-8 -- metabolism KW - Female KW - Male KW - Sick Building Syndrome -- etiology KW - Sick Building Syndrome -- microbiology KW - Airway Obstruction -- etiology KW - Air Pollution, Indoor -- adverse effects KW - Occupational Diseases -- metabolism KW - Respiratory Hypersensitivity -- etiology KW - Airway Obstruction -- microbiology KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Respiratory Hypersensitivity -- metabolism KW - Respiratory Hypersensitivity -- microbiology KW - Occupational Diseases -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70383899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+air&rft.atitle=Respiratory+inflammatory+responses+among+occupants+of+a+water-damaged+office+building.&rft.au=Akpinar-Elci%2C+M%3BSiegel%2C+P+D%3BCox-Ganser%2C+J+M%3BStemple%2C+K+J%3BWhite%2C+S+K%3BHilsbos%2C+K%3BWeissman%2C+D+N&rft.aulast=Akpinar-Elci&rft.aufirst=M&rft.date=2008-04-01&rft.volume=18&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Indoor+air&rft.issn=1600-0668&rft_id=info:doi/10.1111%2Fj.1600-0668.2007.00514.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-20 N1 - Date created - 2008-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0668.2007.00514.x ER - TY - JOUR T1 - Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts. AN - 69647871; 18842697 AB - We have previously reported that metabolism of a series of pyrrolizidine alkaloids in vitro and in vivo generated a set of (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts. It has also been shown that the levels of the DHP-derived DNA adduct formation correlated closely with the tumorigenic potencies of the mice fed with different doses of riddelliine. Retronecine is the necine base and the structurally smallest chemical of the retronecine-type pyrrolizidine alkaloids. Although it has been reported that microsomal metabolism of retronecine generated DHP as a metabolite, it was yet not known whether metabolism of retronecine in vivo could generate DHP-derived DNA adducts and if formed, whether or not the levels of DNA adducts were comparable with those formed from the other tumorigenic retronecine-type pyrrolizidine alkaloids, such as riddelliine, retrorsine, and monocrotaline. In this investigation, the in-vitro and in-vivo metabolic activation of retronecine was studied. Rat liver microsomal metabolism of retronecine in the presence of calf thymus DNA resulted in the formation of a set of DHP-DNA adducts. The metabolism of retronecine N-oxide under similar conditions also formed the similar set of DHP-DNA adducts. The level of DNA adducts from retronecine was enhanced when metabolism by liver microsomes from phenobarbital (PB)-induced rats were used. The DHP-DNA adducts were also found in the liver DNA of female F344 rats treated with retronecine or retronecine N-oxide. The highest level of the total DHP-DNA adducts was found in liver DNA from the rats treated with dehydroretronecine (DHR). The order of the levels of DNA adducts in the liver DNA samples from rats treated with various pyrrolizidine alkaloids was: DHR > riddelliine > riddelliine N-oxide >> retronecine > retronecine N-oxide. The results indicate that 1) retronecine can be metabolized to form DHP by rat liver microsomal enzymes and interacts with DNA to produce DHP-DNA adducts and 2) retronecine N-oxide undergoes the biotransformation to the parent compound, retronecine. The results from this and our previous findings strongly suggest that formation of DHP-DNA adducts may be a potential biomarker for pyrrolizidine alkaloid carcinogenesis. JF - Toxicology and industrial health AU - Yan, J AU - Xia, Q AU - Chou, M W AU - Fu, P P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 181 EP - 188 VL - 24 IS - 3 SN - 0748-2337, 0748-2337 KW - Cyclic N-Oxides KW - 0 KW - DNA Adducts KW - Pyrrolizidine Alkaloids KW - riddelliine KW - 23246-96-0 KW - retronecine KW - 2P5723M6II KW - Monocrotaline KW - 73077K8HYV KW - riddelliine N-oxide KW - 75056-11-0 KW - DNA KW - 9007-49-2 KW - calf thymus DNA KW - 91080-16-9 KW - dehydroretronecine KW - QG6MWR17OH KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Biotransformation KW - Microsomes, Liver -- metabolism KW - Liver -- metabolism KW - Female KW - DNA Adducts -- biosynthesis KW - Monocrotaline -- metabolism KW - Pyrrolizidine Alkaloids -- pharmacokinetics KW - Monocrotaline -- pharmacokinetics KW - Monocrotaline -- analogs & derivatives KW - DNA -- metabolism KW - Cyclic N-Oxides -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69647871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Metabolic+activation+of+retronecine+and+retronecine+N-oxide+-+formation+of+DHP-derived+DNA+adducts.&rft.au=Yan%2C+J%3BXia%2C+Q%3BChou%2C+M+W%3BFu%2C+P+P&rft.aulast=Yan&rft.aufirst=J&rft.date=2008-04-01&rft.volume=24&rft.issue=3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233708093727 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0748233708093727 ER - TY - JOUR T1 - Dexrazoxane (Totect): FDA review and approval for the treatment of accidental extravasation following intravenous anthracycline chemotherapy. AN - 69168460; 18448560 AB - Management of anthracycline extravasation is problematic and most reports are anecdotal. On September 6, 2007, the U.S. Food and Drug Administration approved Totect 500 mg (dexrazoxane hydrochloride for injection) for the treatment of extravasation resulting from i.v. anthracycline chemotherapy. In two studies, a total of 57 evaluable patients experienced extravasation from peripheral vein or central venous access sites with local swelling, pain, or redness. The presence of anthracycline in skin biopsy tissue was confirmed by tissue fluorescence, and treatment with a 3-day schedule of dexrazoxane began within 6 hours of the event. The primary endpoint was a reduction in the need for surgical intervention. Only one patient required surgical repair of the injury site, and late sequelae in the remainder were absent or mild. Also, the sponsor, TopoTarget A/S, Copenhagen, Denmark, performed controlled nonclinical studies in support of dexrazoxane dose and timing for the reduction of tissue injury resulting from anthracycline extravasation. For this uncommon but serious complication of anthracycline therapy, the need for surgical intervention was 1.7% with this regimen. JF - The oncologist AU - Kane, Robert C AU - McGuinn, W David AU - Dagher, Ramzi AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Bldg. 22, Room 2109, Silver Spring, Maryland 20993-0002, USA. robert.kane@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 445 EP - 450 VL - 13 IS - 4 SN - 1083-7159, 1083-7159 KW - Anthracyclines KW - 0 KW - Antibiotics, Antineoplastic KW - Razoxane KW - 5AR83PR647 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Risk Factors KW - Humans KW - Drug Approval KW - Infusions, Intravenous -- adverse effects KW - Razoxane -- therapeutic use KW - Antibiotics, Antineoplastic -- administration & dosage KW - Extravasation of Diagnostic and Therapeutic Materials KW - Anthracyclines -- administration & dosage KW - Anthracyclines -- adverse effects KW - Antibiotics, Antineoplastic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69168460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Dexrazoxane+%28Totect%29%3A+FDA+review+and+approval+for+the+treatment+of+accidental+extravasation+following+intravenous+anthracycline+chemotherapy.&rft.au=Kane%2C+Robert+C%3BMcGuinn%2C+W+David%3BDagher%2C+Ramzi%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Kane&rft.aufirst=Robert&rft.date=2008-04-01&rft.volume=13&rft.issue=4&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/10.1634%2Ftheoncologist.2007-0247 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-17 N1 - Date created - 2008-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2007-0247 ER - TY - JOUR T1 - Genetic contributions to influenza virus attenuation in the rat brain. AN - 69148154; 18444085 AB - Influenza is generally regarded as an infection of the respiratory tract; however, neurological involvement is a well-recognized, although uncommon, complication of influenza A virus infection. The authors previously described the development of a rat model for studying influenza virus infection of the central nervous system (CNS). This model was used here to study the role of virus genes in virus replication and spread in brain. In the present work, an infectious cDNA clone of the neurotoxic WSN strain of influenza virus (rWSN) was altered by site-directed mutagenesis at five loci that corresponded to changes previously shown to confer temperature sensitivity and attenuation of the A/Ann Arbor/6/60 strain (PB1Delta 391, PB1Delta 581, and PB1Delta 661; PB2Delta 265, and NPDelta 34). Whereas rWSN and its mutated derivative (mu-rWSN) replicated equally well in MDCK cells at 37 degrees C (the body temperature of rats), rWSN grew to higher titers and infection was more widespread compared to mu-rWSN in rat brain. These results demonstrate that the five mutations that confer attenuation of the A/Ann Arbor/6/60 influenza virus strain for the respiratory system also confer attenuation for the central nervous system. Further in vivo and in vitro examination of these five mutations, both individually and in combination, will likely provide important information on the role of specific virus genes in virulence and pathogenesis. JF - Journal of neurovirology AU - Qi, Li AU - Carbone, Kathryn M AU - Ye, Zhiping AU - Liu, Teresa AU - Ovanesov, Mikhail AU - Pletnikov, Mikhail AU - Sauder, Christian AU - Rubin, Steven A AD - CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 136 EP - 142 VL - 14 IS - 2 KW - Viral Proteins KW - 0 KW - Index Medicus KW - Rats KW - Mutagenesis, Site-Directed KW - Animals KW - Temperature KW - Orthomyxoviridae Infections -- immunology KW - Virus Replication KW - Viral Proteins -- immunology KW - Viral Proteins -- genetics KW - Influenza A virus -- physiology KW - Central Nervous System -- virology KW - Virulence -- genetics KW - Viral Proteins -- biosynthesis KW - Genes, Viral KW - Influenza A virus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69148154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurovirology&rft.atitle=Genetic+contributions+to+influenza+virus+attenuation+in+the+rat+brain.&rft.au=Qi%2C+Li%3BCarbone%2C+Kathryn+M%3BYe%2C+Zhiping%3BLiu%2C+Teresa%3BOvanesov%2C+Mikhail%3BPletnikov%2C+Mikhail%3BSauder%2C+Christian%3BRubin%2C+Steven+A&rft.aulast=Qi&rft.aufirst=Li&rft.date=2008-04-01&rft.volume=14&rft.issue=2&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurovirology&rft.issn=1538-2443&rft_id=info:doi/10.1080%2F13550280701885563 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-08 N1 - Date created - 2008-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/13550280701885563 ER - TY - JOUR T1 - Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity. AN - 69118775; 18276636 AB - Replication of the mitochondrial genome by DNA polymerase gamma requires dNTP precursors that are subject to oxidation by reactive oxygen species generated by the mitochondrial respiratory chain. One such oxidation product is 8-oxo-dGTP, which can compete with dTTP for incorporation opposite template adenine to yield A-T to C-G transversions. Recent reports indicate that the ratio of undamaged dGTP to dTTP in mitochondrial dNTP pools from rodent tissues varies from approximately 1:1 to >100:1. Within this wide range, we report here the proportion of 8-oxo-dGTP in the dNTP pool that would be needed to reduce the replication fidelity of human DNA polymerase gamma. When various in vivo mitochondrial dNTP pools reported previously were used here in reactions performed in vitro, 8-oxo-dGTP was readily incorporated opposite template A and the resulting 8-oxo-G-A mismatch was not proofread efficiently by the intrinsic 3' exonuclease activity of pol gamma. At the dNTP ratios reported in rodent tissues, whether highly imbalanced or relatively balanced, the amount of 8-oxo-dGTP needed to reduce fidelity was <1% of dGTP. Moreover, direct measurements reveal that 8-oxo-dGTP is present at such concentrations in the mitochondrial dNTP pools of several rat tissues. The results suggest that oxidized dNTP precursors may contribute to mitochondrial mutagenesis in vivo, which could contribute to mitochondrial dysfunction and disease. JF - Nucleic acids research AU - Pursell, Zachary F AU - McDonald, J Tyson AU - Mathews, Christopher K AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 2174 EP - 2181 VL - 36 IS - 7 KW - DNA, Mitochondrial KW - 0 KW - Deoxyguanine Nucleotides KW - Deoxyribonucleotides KW - 8-oxodeoxyguanosine triphosphate KW - 139307-94-1 KW - deoxyguanosine triphosphate KW - 8C2O37Y44Q KW - DNA polymerase gamma KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Wistar KW - Deoxyribonucleotides -- metabolism KW - Mitochondria -- metabolism KW - Mice KW - Mitochondria, Heart -- metabolism KW - Mitochondria, Heart -- genetics KW - Male KW - Deoxyguanine Nucleotides -- metabolism KW - DNA, Mitochondrial -- chemistry KW - DNA, Mitochondrial -- biosynthesis KW - DNA Replication KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69118775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Trace+amounts+of+8-oxo-dGTP+in+mitochondrial+dNTP+pools+reduce+DNA+polymerase+gamma+replication+fidelity.&rft.au=Pursell%2C+Zachary+F%3BMcDonald%2C+J+Tyson%3BMathews%2C+Christopher+K%3BKunkel%2C+Thomas+A&rft.aulast=Pursell&rft.aufirst=Zachary&rft.date=2008-04-01&rft.volume=36&rft.issue=7&rft.spage=2174&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkn062 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-19 N1 - Date created - 2008-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 1989 Feb 7;28(3):988-95 [2713377] Lancet. 1989 Mar 25;1(8639):642-5 [2564461] Proc Natl Acad Sci U S A. 1990 Jun;87(12):4533-7 [2352934] Nature. 1991 Jan 31;349(6308):431-4 [1992344] Nature. 1992 Jan 16;355(6357):273-5 [1309939] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):11021-5 [1332067] Biochemistry. 1994 Apr 19;33(15):4695-701 [8161527] J Biol Chem. 1995 Jun 16;270(24):14659-65 [7782328] J Biol Chem. 1995 Oct 27;270(43):25942-8 [7592783] Methods Enzymol. 1995;262:217-32 [8594349] Biochem J. 1996 Jan 1;313 ( Pt 1):17-29 [8546679] Biochemistry. 1998 Jul 21;37(29):10529-39 [9671525] Science. 1999 Mar 5;283(5407):1482-8 [10066162] Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4990-5 [15784738] J Biol Chem. 2005 Jul 1;280(26):24472-80 [15878850] Science. 2005 Jul 15;309(5733):481-4 [16020738] Structure. 2005 Nov;13(11):1653-9 [16271888] Hum Mol Genet. 2006 Jan 15;15(2):363-74 [16368709] Chem Rev. 2006 Feb;106(2):383-405 [16464011] Mutat Res. 2006 Jul 25;599(1-2):11-20 [16490220] Hum Mol Genet. 2006 Oct 1;15(19):2846-55 [16940310] J Biol Chem. 2006 Nov 24;281(47):36241-8 [17005553] Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18586-91 [17124168] Lab Invest. 2007 Apr;87(4):326-35 [17310215] Nat Genet. 2007 Apr;39(4):540-3 [17334366] Nucleic Acids Res. 2007;35(9):3076-86 [17452367] FASEB J. 2007 Aug;21(10):2294-303 [17403938] Hum Mol Genet. 2007 Nov 15;16(22):2729-39 [17725985] Science. 1999 Oct 22;286(5440):774-9 [10531063] J Biol Chem. 1999 Dec 31;274(53):38197-203 [10608893] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] J Biol Chem. 2002 May 3;277(18):15807-12 [11856756] J Biol Chem. 2002 May 3;277(18):15225-8 [11897778] Structure. 2003 Jan;11(1):121-7 [12517346] EMBO Rep. 2003 Mar;4(3):269-73 [12634844] J Biol Chem. 2003 Sep 26;278(39):37965-73 [12857738] J Biol Chem. 2004 Apr 23;279(17):17019-26 [14747464] Nature. 2004 May 27;429(6990):417-23 [15164064] EMBO J. 2004 Sep 1;23(17):3452-61 [15297882] J Biol Chem. 1988 Mar 25;263(9):4450-9 [2831231] Proc Natl Acad Sci U S A. 1989 Sep;86(17):6469-73 [2671990] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkn062 ER - TY - JOUR T1 - NIEHS extramural global environmental health portfolio: opportunities for collaboration. AN - 69102273; 18414621 AB - Global environmental health has emerged as a critical topic for environmental health researchers and practitioners. Estimates of the environmental contribution of total worldwide disease burden range from 25 to 33%. We reviewed grants funded by the National Institute of Environmental Health Sciences (NIEHS) during 2005-2007 to evaluate the costs and scientific composition of the global environmental health portfolio, with the ultimate aim of strengthening global environmental health research partnerships. We examined NIEHS grant research databases to identify the global environmental health portfolio. In the past 3 fiscal years (2005-2007), the NIEHS funded 57 scientific research projects in 37 countries, at an estimated cost of $30 million. Metals such as arsenic, methylmercury, and lead are the most frequently studied toxic agents, but a wide range of stressors, routes of exposure, and agents are addressed in the portfolio. The portfolio analysis indicates that there is a firm foundation of research activities upon which additional global environmental health partnerships could be encouraged. Current data structures could be strengthened to support more automated analysis of grantee information. JF - Environmental health perspectives AU - Drew, Christina H AU - Barnes, Martha I AU - Phelps, Jerry AU - Van Houten, Bennett AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. drewc@niehs.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 421 EP - 425 VL - 116 IS - 4 SN - 0091-6765, 0091-6765 KW - Environmental Pollutants KW - 0 KW - Metals KW - Index Medicus KW - partnerships KW - global health KW - science assessment KW - Humans KW - Research Support as Topic KW - Metals -- toxicity KW - Global Health KW - Research -- organization & administration KW - Environmental Pollutants -- toxicity KW - Environmental Exposure -- adverse effects KW - Environmental Pollution -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69102273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=NIEHS+extramural+global+environmental+health+portfolio%3A+opportunities+for+collaboration.&rft.au=Drew%2C+Christina+H%3BBarnes%2C+Martha+I%3BPhelps%2C+Jerry%3BVan+Houten%2C+Bennett&rft.aulast=Drew&rft.aufirst=Christina&rft.date=2008-04-01&rft.volume=116&rft.issue=4&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11323 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-11 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiology. 1999 Sep;10(5):573-84 [10468437] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.11323 ER - TY - RPRT T1 - Developmental Status and Early Intervention Service Needs of Maltreated Children. Final Report AN - 61965222; ED501753 AB - This report describes the extent to which maltreated children have developmental problems or are subject to factors associated with poor developmental outcomes, what services these children might be eligible to receive, what factors influence service receipt, and what solutions have been devised to address barriers to service provision. This final report presents findings from an analysis of the "National Early Intervention Longitudinal Study" (NEILS) and the "National Survey of Child and Adolescent Well-Being" (NSCAW) to provide information about the developmental status and early intervention service needs of children under age three who are substantiated for maltreatment. The study found that: (1) children ages birth to 36 months who have been maltreated are at substantial risk of experiencing subsequent developmental problems; (2) compared to classification at the time of initial contact with Child Welfare Services, over time a higher proportion of children are described as having fewer risks or with a low score on a developmental measure while over time a smaller proportion of children are described as having more risks; (3) few infants and toddlers with substantiated cases of maltreatment are reported to have a diagnosed medical condition (an established risk condition) as described in IDEA (e.g., Down syndrome, blindness, cerebral palsy) that would make them automatically eligible for Part C services; (4) among children who have substantiated maltreatment, the proportion with a low score on a developmental measure does not differ markedly from those of children investigated but not found to have substantiated maltreatment; (5) maltreated children between 24 to 36 months of age have relatively high levels of behavior problems reported by their caregivers; (6) a sizeable proportion of infants and toddlers with substantiated maltreatment were reported to have an Individualized Family Service Plan (IFSP), reflecting eligibility for Part C services; (7) families are receiving parent training and family counseling services through Child Welfare Services or by referral. It is unclear the extent to which these services provide interventions focused on enhancing child development; (8) Part C providers may not be familiar with the unique challenges associated with providing services to maltreated children and their families; and (9) increased training and collaboration of Child Welfare and Part C service providers may be a useful approach to facilitate CAPTA compliance and enhance developmental outcomes for children. This study confirms that the level of risk for developmental delay is high for maltreated children and that it remains high, years after the initial maltreatment. (Contains 15 exhibits.) AU - Barth, Richard P. AU - Scarborough, Anita A. AU - Lloyd, Christopher E. AU - Losby, Jan L. AU - Casanueva, Cecilia AU - Mann, Tammy Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 70 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - Individuals with Disabilities Education Act KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Parent Education KW - At Risk Persons KW - Toddlers KW - Young Children KW - Individual Characteristics KW - Individualized Family Service Plans KW - Developmental Delays KW - Counseling Services KW - Intervention KW - Child Welfare KW - Behavior Problems KW - Eligibility KW - Health Needs KW - Federal Legislation KW - Family Programs KW - Early Intervention KW - Social Services KW - Child Development KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61965222?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Evaluation of Gatekeeper Training for Suicide Prevention in Veterans AN - 57246031; 200822141 AB - Clinical providers and 'front line' nonclinical staff who work with veterans, families, and communities are natural gatekeepers to identify and to refer veterans at risk for suicide. A national cohort (n=602) of community based counseling center staff from the U.S. Department of Veterans Affairs (VA) participated in an evaluation of a brief standardized gatekeeper training program and a scripted behavioral rehearsal practice session. A significant difference in knowledge and self efficacy was observed from pre to post (p<.0001) with the nonclinicians showing larger effect sizes for knowledge (0.96 vs. 0.42) and self efficacy (0.89 vs. 0.41). Gatekeeper training for suicide prevention shows promise for increasing the capacity of VA staff to work with at risk veterans. JF - Archives of Suicide Research AU - Matthieu, Monica M AU - Cross, Wendi AU - Batres, Alfonso R AU - Flora, Charles M AU - Knox, Kerry L AD - Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research, St. Louis, MO Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 148 EP - 154 PB - Taylor & Francis, Philadelphia PA VL - 12 IS - 2 SN - 1381-1118, 1381-1118 KW - Assessment KW - Lay people KW - Veterans KW - Referrals KW - Suicide KW - Preventive programmes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57246031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Suicide+Research&rft.atitle=Evaluation+of+Gatekeeper+Training+for+Suicide+Prevention+in+Veterans&rft.au=Matthieu%2C+Monica+M%3BCross%2C+Wendi%3BBatres%2C+Alfonso+R%3BFlora%2C+Charles+M%3BKnox%2C+Kerry+L&rft.aulast=Matthieu&rft.aufirst=Monica&rft.date=2008-04-01&rft.volume=12&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Archives+of+Suicide+Research&rft.issn=13811118&rft_id=info:doi/10.1080%2F13811110701857491 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - ASREFQ N1 - SubjectsTermNotLitGenreText - Veterans; Preventive programmes; Lay people; Assessment; Suicide; Referrals DO - http://dx.doi.org/10.1080/13811110701857491 ER - TY - JOUR T1 - Prediction of Heat-Illness Symptoms with the Prediction of Human Vascular Response in Hot Environment Under Resting Condition AN - 216793198; 18461820 AB - The thermoregulatory control of human skin blood flow is vital to maintain the body heat storage during challenges of thermal homeostasis under heat stress. Whenever thermal homeostasis disturbed, the heat load exceeds heat dissipation capacity, which alters the cutaneous vascular responses along with other body physiological variables. Whole body skin blood flow has been calculated from the forearm blood flow. Present model has been designed using electronics circuit simulator (Multisim 8.0, National Instruments, USA), is to execute a series of predictive equations for early prediction of physiological parameters of young nude subjects during resting condition at various level of dry heat stress under almost still air to avoid causalities associated with hot environmental. The users can execute the model by changing the environmental temperature in °C and exposure time in minutes. The model would be able to predict and detect the changes in human vascular responses along with other physiological parameters and from this predicted values heat related-illness symptoms can be inferred. [PUBLICATION ABSTRACT] JF - Journal of Medical Systems AU - Aggarwal, Yogender AU - Karan, Bhuwan Mohan AU - Das, Barda Nand AU - Sinha, Rakesh Kumar Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 167 EP - 76 CY - New York PB - Springer Science & Business Media VL - 32 IS - 2 SN - 0148-5598 KW - Medical Sciences--Computer Applications KW - Temperature KW - Physiology KW - Heatstroke KW - Humans KW - Body Temperature Regulation -- physiology KW - Skin -- blood supply KW - Hot Temperature KW - Rest -- physiology KW - Blood Vessels -- radiation effects KW - Predictive Value of Tests KW - Heat Stroke UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/216793198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomputing&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Systems&rft.atitle=Prediction+of+Heat-Illness+Symptoms+with+the+Prediction+of+Human+Vascular+Response+in+Hot+Environment+Under+Resting+Condition&rft.au=Aggarwal%2C+Yogender%3BKaran%2C+Bhuwan+Mohan%3BDas%2C+Barda+Nand%3BSinha%2C+Rakesh+Kumar&rft.aulast=Aggarwal&rft.aufirst=Yogender&rft.date=2008-04-01&rft.volume=32&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Systems&rft.issn=01485598&rft_id=info:doi/10.1007%2Fs10916-007-9119-3 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2008 N1 - Document feature - References N1 - Last updated - 2014-07-26 DO - http://dx.doi.org/10.1007/s10916-007-9119-3 ER - TY - JOUR T1 - Automatic assessment of dynamic contrast-enhanced MRI in an ischemic rat hindlimb model: an exploratory study of transplanted multipotent progenitor cells AN - 21067311; 8632284 AB - This study presents computerized automatic image analysis for quantitatively evaluating dynamic contrast-enhanced MRI in an ischemic rat hindlimb model. MRI at 7T was performed on animals in a blinded placebo-controlled experiment comparing multipotent adult progenitor cell-derived progenitor cell (MDPC)-treated, phosphate buffered saline (PBS)-injected, and sham-operated rats. Ischemic and non-ischemic limb regions of interest were automatically segmented from time-series images for detecting changes in perfusion and late enhancement. In correlation analysis of the time-signal intensity histograms, the MDPC-treated limbs correlated well with their corresponding non-ischemic limbs. However, the correlation coefficient of the PBS control group was significantly lower than that of the MDPC-treated and sham-operated groups. In semi-quantitative parametric maps of contrast enhancement, there was no significant difference in hypo-enhanced area between the MDPC and PBS groups at early perfusion-dependent time frames. However, the late-enhancement area was significantly larger in the PBS than the MDPC group. The results of this exploratory study show that MDPC-treated rats could be objectively distinguished from PBS controls. The differences were primarily determined by late contrast enhancement of PBS-treated limbs. These computerized methods appear promising for assessing perfusion and late enhancement in dynamic contrast-enhanced MRI. Published in 2007 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Hsu, Li-Yueh AU - Wragg, Andrew AU - Anderson, Stasia A AU - Balaban, Robert S AU - Boehm, Manfred AU - Arai, Andrew E AD - National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, araia@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 111 EP - 119 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 21 IS - 2 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Stem cells KW - Perfusion KW - Limbs KW - Phosphate KW - Magnetic resonance imaging KW - Animal models KW - Image processing KW - N.M.R. KW - Correlation analysis KW - Ischemia KW - Maps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21067311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Automatic+assessment+of+dynamic+contrast-enhanced+MRI+in+an+ischemic+rat+hindlimb+model%3A+an+exploratory+study+of+transplanted+multipotent+progenitor+cells&rft.au=Hsu%2C+Li-Yueh%3BWragg%2C+Andrew%3BAnderson%2C+Stasia+A%3BBalaban%2C+Robert+S%3BBoehm%2C+Manfred%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2008-04-01&rft.volume=21&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1166 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Limbs; Magnetic resonance imaging; Stem cells; Ischemia; Animal models; Perfusion; Maps; N.M.R.; Image processing; Correlation analysis; Phosphate DO - http://dx.doi.org/10.1002/nbm.1166 ER - TY - JOUR T1 - FDA perspective on antivirals against biothreats: Communicate early and often AN - 21025540; 8254163 AB - Development of antiviral products for certain highly pathogenic viruses with limited available treatments, such as viruses that may have biothreat potential, is critically important and challenging. The mission of the FDA is to protect the public health by assuring the safety, efficacy and quality of such products. Human clinical trials are critically important whenever relevant naturally occurring diseases can appropriately be studied. In selected situations when clinical studies are not ethical and field efficacy studies are not feasible, the Animal Rule (67 FR 37988, 2002) introduces the possibility of drug/biologic approval/licensure based on efficacy studies in animals, and appropriate human safety and pharmacokinetic information. This approach necessitates the development of well-delineated animal models predictive of human disease and treatment responses, and plans for adding human information if suitable circumstances arise. Efficient development of therapeutics against these agents requires collaborative efforts among industry, academia and federal agencies. JF - Antiviral Research AU - Roberts, R AU - Styrt, B AU - McCune, S AD - Center for Drug Evaluation and Research, Office of Counter-Terrorism and Emergency Coordination, 10903 New Hampshire Avenue, White Oak Campus, Silver Spring, MD 20993, United States, rosemary.roberts@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 60 EP - 63 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 78 IS - 1 SN - 0166-3542, 0166-3542 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Antiviral agents KW - Ethics KW - Animal models KW - Drug development KW - Clinical trials KW - Pharmacokinetics KW - Public health KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21025540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=FDA+perspective+on+antivirals+against+biothreats%3A+Communicate+early+and+often&rft.au=Roberts%2C+R%3BStyrt%2C+B%3BMcCune%2C+S&rft.aulast=Roberts&rft.aufirst=R&rft.date=2008-04-01&rft.volume=78&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2007.10.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antiviral agents; Ethics; Animal models; Drug development; Clinical trials; Pharmacokinetics; Public health DO - http://dx.doi.org/10.1016/j.antiviral.2007.10.001 ER - TY - JOUR T1 - Determination of Molecular Phylogenetics of Vibrio parahaemolyticus Strains by Multilocus Sequence Typing AN - 20964884; 8199429 AB - Vibrio parahaemolyticus is an important human pathogen whose transmission is associated with the consumption of contaminated seafood. There is a growing public health concern due to the emergence of a pandemic strain causing severe outbreaks worldwide. Many questions remain unanswered regarding the evolution and population structure of V. parahaemolyticus. In this work, we describe a multilocus sequence typing (MLST) scheme for V. parahaemolyticus based on the internal fragment sequences of seven housekeeping genes. This MLST scheme was applied to 100 V. parahaemolyticus strains isolated from geographically diverse clinical (n = 37) and environmental (n = 63) sources. The sequences obtained from this work were deposited and are available in a public database (http://pubmlst.org/vparahaemolyticus). Sixty-two unique sequence types were identified, and most (50) were represented by a single isolate, suggesting a high level of genetic diversity. Three major clonal complexes were identified by eBURST analysis. Separate clonal complexes were observed for V. parahaemolyticus isolates originating from the Pacific and Gulf coasts of the United States, while a third clonal complex consisted of strains belonging to the pandemic clonal complex with worldwide distribution. The data reported in this study indicate that V. parahaemolyticus is genetically diverse with a semiclonal population structure and an epidemic structure similar to that of Vibrio cholerae. Genetic diversity in V. parahaemolyticus appears to be driven primarily by frequent recombination rather than mutation, with recombination ratios estimated at 2.5:1 and 8.8:1 by allele and site, respectively. Application of this MLST scheme to more V. parahaemolyticus strains and by different laboratories will facilitate production of a global picture of the epidemiology and evolution of this pathogen. JF - Journal of Bacteriology AU - Gonzalez-Escalona, Narjol AU - Martinez-Urtaza, Jaime AU - Romero, Jaime AU - Espejo, Romilio T AU - Jaykus, Lee-Ann AU - DePaola, Angelo AD - Department of Food Science, North Carolina State University, Raleigh, North Carolina. Instituto de Acuicultura, Universidad de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela, Spain. Laboratorio de Biotecnologia, Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile. Gulf Coast Seafood Laboratory, Food and Drug Administration, Dauphin Island, Alabama. Center for Food and Applied Nutrition, Food and Drug Administration, College Park, Maryland Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 2831 EP - 2840 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 8 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Phylogeny KW - Epidemics KW - Data processing KW - Genetic diversity KW - Pathogens KW - Public health KW - multilocus sequence typing KW - Disease transmission KW - Vibrio cholerae KW - Recombination KW - Databases KW - pandemics KW - Epidemiology KW - Vibrio parahaemolyticus KW - Population structure KW - Seafood KW - Mutation KW - Evolution KW - Coasts KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20964884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Determination+of+Molecular+Phylogenetics+of+Vibrio+parahaemolyticus+Strains+by+Multilocus+Sequence+Typing&rft.au=Gonzalez-Escalona%2C+Narjol%3BMartinez-Urtaza%2C+Jaime%3BRomero%2C+Jaime%3BEspejo%2C+Romilio+T%3BJaykus%2C+Lee-Ann%3BDePaola%2C+Angelo&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2008-04-01&rft.volume=190&rft.issue=8&rft.spage=2831&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phylogeny; Data processing; Epidemics; Genetic diversity; Pathogens; Disease transmission; multilocus sequence typing; Public health; Databases; Recombination; pandemics; Epidemiology; Population structure; Seafood; Mutation; Evolution; Coasts; Vibrio cholerae; Vibrio parahaemolyticus ER - TY - JOUR T1 - Flow Cytometric Analysis of Micronuclei in Peripheral Blood Reticulocytes IV: An Index of Chromosomal Damage in the Rhesus Monkey (Macaca mulatta) AN - 20924627; 8090211 AB - We report evaluation in rhesus monkeys of a flow cytometric procedure (MicroFlow) that has previously been shown to allow assessment of micronucleated reticulocytes (MN-RETs) in the peripheral blood of rats and dogs. Reticulocytes (RETs) were labeled with anti-CD71-fluorescein isothiocyanate, DNA was stained with propidium iodide using RNase treatment, and anti-CD61-phycoerythrin was used to reduce interference from platelets. Flow cytometric data were compared with microscopic scores of peripheral blood and bone marrow using standard acridine orange staining. A single iv administration of cyclophosphamide (CP, 5 mg/kg) induced an approximately 10-fold increase in blood MN-RET frequency, with the peak occurring 2 days after administration. After daily CP treatment to approximate a steady-state condition, the frequency of MN-RETs in peripheral blood was approximately 25% of that in bone marrow, indicating strong selection against MN-RETs. Nonetheless, CP-treated animals exhibited markedly elevated blood MN-RET values (2.45-3.99%, n = 3; compared to a mean baseline of 0.12%, n = 6). These measurements closely reflected the increased frequencies observed in the bone marrow compartment (Spearman correlation coefficient = 0.9856, n = 6). These data suggest that MN-RET measurements in blood are suitable for assessing chemical-induced chromosomal damage and can be readily integrated into routine toxicity tests, allowing genotoxicity data to be obtained as an integral part of toxicity evaluations. Microscopy-based scoring is challenging due to the low frequency of RETs and MN-RET in monkeys, but sufficient numbers of cells are easily scored with the flow cytometric procedure. JF - Toxicological Sciences AU - Hotchkiss, Charlotte E AU - Bishop, Michelle E AU - Dertinger, Stephen D AU - Slikker, William Jr AU - Moore, Martha M AU - MacGregor, James T AD - The Bionetics Corporation, Jefferson, Arkansas72079. National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, 72079. Litron Laboratories, Rochester, New York, 14623. National Center for Toxicological Research, U.S. Food and Drug Administration, Rockville, Maryland, 20857 Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 352 EP - 358 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 102 IS - 2 SN - 1096-6080, 1096-6080 KW - Rhesus macaque KW - Rhesus monkey KW - Genetics Abstracts; Toxicology Abstracts KW - Acridine orange KW - Data processing KW - propidium iodide KW - Genotoxicity KW - Micronuclei KW - Bone marrow KW - Peripheral blood KW - Cyclophosphamide KW - Flow cytometry KW - Platelets KW - DNA KW - Ribonuclease KW - Macaca mulatta KW - Reticulocytes KW - isothiocyanate KW - G 07870:Mammals KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20924627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Flow+Cytometric+Analysis+of+Micronuclei+in+Peripheral+Blood+Reticulocytes+IV%3A+An+Index+of+Chromosomal+Damage+in+the+Rhesus+Monkey+%28Macaca+mulatta%29&rft.au=Hotchkiss%2C+Charlotte+E%3BBishop%2C+Michelle+E%3BDertinger%2C+Stephen+D%3BSlikker%2C+William+Jr%3BMoore%2C+Martha+M%3BMacGregor%2C+James+T&rft.aulast=Hotchkiss&rft.aufirst=Charlotte&rft.date=2008-04-01&rft.volume=102&rft.issue=2&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Acridine orange; Data processing; propidium iodide; Micronuclei; Genotoxicity; Bone marrow; Peripheral blood; Cyclophosphamide; Flow cytometry; DNA; Platelets; Ribonuclease; Reticulocytes; isothiocyanate; Macaca mulatta ER - TY - JOUR T1 - Irritancy and Sensitization Potential of Glyoxylic Acid AN - 20887860; 8403980 AB - Glyoxylic acid, a small dicarboxylic acid, has been detected at measurable levels in the atmosphere and is suspected to be present in indoor air environments. It is generated through the ozonolysis of several high volume production compounds that are commonly found indoors. Glyoxylic acid was tested in a combined irritancy and local lymph node assay (LLNA). It tested positive in the LLNA with an EC3 value of 5.05%. Significant increases were observed in the B220+cell population in the draining lymph nodes. No changes were identified in the IgE+B220+ cell population in the draining lymph nodes or total serum IgE levels; this suggests that glyoxylic acid functions as a T-cell-mediated contact sensitizer. Exposure to volatile organic compounds (VOC), similar to glyoxylic acid, emitted from building materials, cleaning formulations or other consumer products, and /or indoor chemistry have been linked to adverse health effects. These results may provide an explanation for some of adverse health effects associated with indoor air exposure. JF - Journal of Immunotoxicology AU - Anderson, Stacey E AU - Ham, Jason E AU - Munson, Albert E AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 93 EP - 98 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 2 SN - 1547-691X, 1547-691X KW - Toxicology Abstracts; Immunology Abstracts KW - F 06910:Microorganisms & Parasites KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20887860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunotoxicology&rft.atitle=Irritancy+and+Sensitization+Potential+of+Glyoxylic+Acid&rft.au=Anderson%2C+Stacey+E%3BHam%2C+Jason+E%3BMunson%2C+Albert+E&rft.aulast=Anderson&rft.aufirst=Stacey&rft.date=2008-04-01&rft.volume=5&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunotoxicology&rft.issn=1547691X&rft_id=info:doi/10.1080%2F15476910802085681 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/15476910802085681 ER - TY - JOUR T1 - Fully automatic, retrospective enhancement of real-time acquired cardiac cine MR images using image-based navigators and respiratory motion-corrected averaging AN - 20857696; 8368752 AB - Real-time imaging may be clinically important in patients with congestive heart failure, arrhythmias, or in pediatric cases. However, real-time imaging typically has compromised spatial and temporal resolution compared with gated, segmented studies. To combine the best features of both types of imaging, a new method is proposed that uses parallel imaging to improve temporal resolution of real-time acquired images at the expense of signal-to-noise ratio (SNR), but then produces an SNR-enhanced cine by means of respiratory motion-corrected averaging of images acquired in real-time over multiple heartbeats while free-breathing. The retrospective processing based on image-based navigators and nonrigid image registration is fully automated. The proposed method was compared with conventional cine images in 21 subjects. The resultant image quality for the proposed method (3.9 - 0.44) was comparable to the conventional cine (4.2 - 0.99) on a 5-point scale (P = not significant [n.s.]). The conventional method exhibited degraded image quality in cases of arrhythmias whereas the proposed method had uniformly good quality. Motion-corrected averaging of real-time acquired cardiac images provides a means of attaining high-quality cine images with many of the benefits of real-time imaging, such as free-breathing acquisition and tolerance to arrhythmias. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Chefd'hotel, Christophe AU - Lorenz, Christine H AU - Mancini, Christine AU - Arai, Andrew E AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 771 EP - 778 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Arrhythmia KW - Pediatrics KW - N.M.R. KW - congestive heart failure KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Fully+automatic%2C+retrospective+enhancement+of+real-time+acquired+cardiac+cine+MR+images+using+image-based+navigators+and+respiratory+motion-corrected+averaging&rft.au=Kellman%2C+Peter%3BChefd%27hotel%2C+Christophe%3BLorenz%2C+Christine+H%3BMancini%2C+Christine%3BArai%2C+Andrew+E%3BMcVeigh%2C+Elliot+R&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2008-04-01&rft.volume=59&rft.issue=4&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21509 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - imaging; Arrhythmia; Pediatrics; N.M.R.; congestive heart failure DO - http://dx.doi.org/10.1002/mrm.21509 ER - TY - JOUR T1 - Modification of the Submerged Coil To Prevent Microbial Carryover Error in Thermal Death Studies AN - 20846666; 8189921 AB - A submerged coil unit generates death rate data for foodborne pathogens through precise computer-controlled sequential sampling rather than the usual manually timed, labor-intensive single sampling associated with other approaches. Our work with Yersinia pseudotuberculosis and Listeria monocytogenes Scott A using the submerged coil unit indicated non-log-linear death rates with large degrees of tailing. Varying degrees of cell adhesion to the surface of the exit port resulted in carryover that was likely the primary cause of these non-log-linear kinetics. This carryover also resulted in erroneously high measured levels of thermal resistance for both organisms. To address the carryover problem, modifications were made to the exit port of the submerged coil unit to ensure continuous and uniform heat treatment. These modifications resulted in a 2-fold decrease in measured D-values for L. monocytogenes Scott A and a 10-fold decrease in measured D- values for Y. pseudotuberculosis. D-values measured with the modified machine for L. monocytogenes Scott A were similar to those found in the literature. Slight tailing in survival curves persisted with the modified method, particularly for Y. pseudotuberculosis. These results indicate that kinetic data for microbial death rates obtained using an unmodified submerged coil unit must be viewed with suspicion in light of the significant potential for carryover. JF - Journal of Food Protection AU - Keller, Susanne E AU - Shazer, Arlette G AU - Fleischman, Gregory J AU - Chirtel, Stuart AU - Anderson, Nathan AU - Larkin, John AD - U.S. Food and Drug Administration Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 775 EP - 780 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 71 IS - 4 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Listeria monocytogenes KW - Mortality KW - Food KW - Yersinia pseudotuberculosis KW - Survival KW - Pathogens KW - Mine tailings KW - Cell adhesion KW - Kinetics KW - adhesion KW - Sampling KW - survival KW - Pseudotuberculosis KW - Heat treatments KW - A 01330:Food Microbiology KW - J 02490:Miscellaneous KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20846666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Modification+of+the+Submerged+Coil+To+Prevent+Microbial+Carryover+Error+in+Thermal+Death+Studies&rft.au=Keller%2C+Susanne+E%3BShazer%2C+Arlette+G%3BFleischman%2C+Gregory+J%3BChirtel%2C+Stuart%3BAnderson%2C+Nathan%3BLarkin%2C+John&rft.aulast=Keller&rft.aufirst=Susanne&rft.date=2008-04-01&rft.volume=71&rft.issue=4&rft.spage=775&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282008%29071%253C0775%3AMOTSCT%253E2.3.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Food; Kinetics; Survival; Pathogens; Sampling; Heat treatments; Pseudotuberculosis; Cell adhesion; Mortality; adhesion; survival; Mine tailings; Listeria monocytogenes; Yersinia pseudotuberculosis DO - http://dx.doi.org/10.1043/0362-028X(2008)071%3C0775:MOTSCT%3E2.3.CO;2 ER - TY - JOUR T1 - Evaluation of multiple strains of Enterobacter sakazakii using fatty acid profiles AN - 20838511; 7916669 AB - Fatty acid profiles are useful for identifying Gram-negative Enterobacter sakazakii strains within the family Enterobacteriaceae. The majority of cases of E. sakazakii infection have involved sepsis, meningitis, or enteritis, especially in neonates and infants. Gas chromatography with flame ionization detection (GC-FID) was utilized for the analysis of cellular fatty acid methyl esters (FAMEs). Thirty E. sakazakiistrains isolated from food and environmental sources were cultured for 24h on brain heart infusion (BHI) agar on three different days at 37°C. Whole cell FAMEs were obtained by saponification, methylation and extraction into hexane:methyl tert-butyl ether. The day to day variations for the 30 E. sakazakii strains for each fatty acid were determined. Gram-negative bacteria commonly contain combinations of straight-chain, unsaturated, hydroxyl, and cyclo fatty acids. Major fatty acids of E. sakazakii strains evaluated in this study were straight chain 12:0, 14:0, 16:0 and unsaturated 16:1, 18:1, and 17:0 omega cyclo 7-8. Analysis of FAMEs from E. sakazakii strains grown on BHI agar by this rapid GC-FID method is highly reproducible and provides a sensitive procedure for identification of this organism. The fatty acid profile assay could be used to rapidly screen infant formula samples for E. sakazakii and reduce the time required for the current assay by up to 5days. JF - Food Chemistry AU - Hoffmann, Maria AU - Keys, Christine E AU - Song, Kwang-Young AU - Brown, Eric W AU - Fry, Frederick S AU - Whittaker, Paul AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, USA, paul.whittaker@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1623 EP - 1628 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 107 IS - 4 SN - 0308-8146, 0308-8146 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Gas chromatography KW - Fatty acids KW - Enterobacter sakazakii KW - Heart KW - Agar KW - Infant formulas KW - Enteritis KW - Brain KW - Infection KW - Meningitis KW - Sepsis KW - Food sources KW - Gram-negative bacteria KW - fatty acid methyl esters KW - Ethers KW - Neonates KW - Methylation KW - Ionization KW - Enterobacteriaceae KW - Infants KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20838511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Chemistry&rft.atitle=Evaluation+of+multiple+strains+of+Enterobacter+sakazakii+using+fatty+acid+profiles&rft.au=Hoffmann%2C+Maria%3BKeys%2C+Christine+E%3BSong%2C+Kwang-Young%3BBrown%2C+Eric+W%3BFry%2C+Frederick+S%3BWhittaker%2C+Paul&rft.aulast=Hoffmann&rft.aufirst=Maria&rft.date=2008-04-01&rft.volume=107&rft.issue=4&rft.spage=1623&rft.isbn=&rft.btitle=&rft.title=Food+Chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2007.10.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heart; Agar; Infant formulas; Enteritis; Brain; Infection; Meningitis; Sepsis; Gas chromatography; Gram-negative bacteria; Food sources; fatty acid methyl esters; Fatty acids; Neonates; Ethers; Ionization; Methylation; Infants; Enterobacter sakazakii; Enterobacteriaceae DO - http://dx.doi.org/10.1016/j.foodchem.2007.10.032 ER - TY - JOUR T1 - Extended-spectrum b-lactamase (ESBL)-producing enterobacteria: factors associated with infection in the community setting, Auckland, New Zealand AN - 20823943; 8337756 AB - We aimed to document the epidemiology of extended-spectrum b-lactamase (ESBL)-producing enterobacteria in the Auckland community and identify factors associated with infection using a case-control study design. ESBL-producing enterobacteria were isolated from 107 infected patients, for which demographic and clinical data were available for 98 cases (92%). Escherichia coli was the predominant organism (82%), with urine as the commonest source (97%). Compared with a control group infected with ESBL-negative enterobacteria, factors significantly associated with infection on univariate analysis were: living in a residential care home (RCH); recent admission to hospital 'M'; recent antibiotic use; older age (>75 years); presence of a urinary catheter; and a history of comorbid chronic obstructive pulmonary disease (COPD), cardiovascular disease, neurological disease or recurrent urinary tract infection. On multivariate analysis, residence in RCH and COPD remained significant associations. Pulsed-field gel electrophoresis typing of the ESBL-producing E. coli identified a common strain. We concluded that residence in RCH and a history of COPD are significant associations with ESBL-producing enterobacterial infection in the Auckland community. Several spatial clusters in RCHs and a common strain suggest point-source outbreaks. A substantial number of community cases did not live in an RCH nor had been recently hospitalised, suggesting the independent generation of ESBL-producing enterobacteria in the broader community. JF - Journal of Hospital Infection AU - Moor, C T AU - Roberts, S A AU - Simmons, G AU - Briggs, S AU - Morris, A J AU - Smith, J AU - Heffernan, H AD - Auckland Regional Public Health Service, Auckland, New Zealand, gregs@adhb.govt.nz Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 355 EP - 362 PB - W.B. Saunders Company, Periodicals Order Fulfillment Dept. 6277 Sea Harbor Drive Orlando, FL 32887-4800 USA, [mailto:hhspcs@harcourt.com], [URL:http://www.wbsaunders.com] VL - 68 IS - 4 SN - 0195-6701, 0195-6701 KW - Microbiology Abstracts B: Bacteriology KW - Antimicrobial drug resistance KW - Beta-lactamases KW - Community-acquired infections KW - Risk factors KW - Neurological diseases KW - Antibiotics KW - Urinary tract KW - Chronic obstructive pulmonary disease KW - Demography KW - Typing KW - Epidemiology KW - Urine KW - Multivariate analysis KW - Chronic infection KW - Escherichia coli KW - Geriatrics KW - Catheters KW - Pulsed-field gel electrophoresis KW - Recurrent infection KW - Cardiovascular diseases KW - b-Lactamase KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20823943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hospital+Infection&rft.atitle=Extended-spectrum+b-lactamase+%28ESBL%29-producing+enterobacteria%3A+factors+associated+with+infection+in+the+community+setting%2C+Auckland%2C+New+Zealand&rft.au=Moor%2C+C+T%3BRoberts%2C+S+A%3BSimmons%2C+G%3BBriggs%2C+S%3BMorris%2C+A+J%3BSmith%2C+J%3BHeffernan%2C+H&rft.aulast=Moor&rft.aufirst=C&rft.date=2008-04-01&rft.volume=68&rft.issue=4&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hospital+Infection&rft.issn=01956701&rft_id=info:doi/10.1016%2Fj.jhin.2008.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neurological diseases; Antibiotics; Urinary tract; Chronic obstructive pulmonary disease; Demography; Typing; Epidemiology; Multivariate analysis; Urine; Chronic infection; Pulsed-field gel electrophoresis; Catheters; Geriatrics; Recurrent infection; b-Lactamase; Cardiovascular diseases; Hospitals; Escherichia coli DO - http://dx.doi.org/10.1016/j.jhin.2008.02.003 ER - TY - JOUR T1 - A Multilevel Analysis of State and Regional Disparities in Childhood and Adolescent Obesity in the United States AN - 20812823; 8156431 AB - This study examines state- and regional disparities in obesity prevalence among 46,707 US children and adolescents aged 10-17 years before and after adjusting for individual socioeconomic and behavioral characteristics and area deprivation measures. The 2003 National Survey of Children's Health was used to calculate obesity prevalence in nine geographic regions and in the 50 states and the District of Columbia (DC). Logistic regression was used to estimate odds of obesity and adjusted prevalence. OLS regression was used to determine the amount of variance explained by income inequality, poverty, and violent crime rates. The prevalence of childhood obesity varied substantially across geographic areas, with the Southcentral regions of the US having the highest prevalence ( greater than or equal to 18%) and the Mountain region the lowest prevalence (11.4%). Children in West Virginia, Kentucky, Texas, Tennessee, and North Carolina (adjusted prevalence > 18.3%) had over twice the odds of being obese than their Utah counterparts (adjusted prevalence = 10.4%). Geographic disparities in obesity were similar for male and female children. Individual characteristics such as race/ethnicity, household socioeconomic status, neighborhood social capital, television viewing, recreational computer use, and physical activity accounted for 55% of the state and 25% of the regional disparities in obesity. Area poverty rates accounted for an additional 18% of the state variance in adjusted obesity prevalence. Although individual and area level socioeconomic factors are important predictors, substantial geographic disparities in childhood and adolescent obesity remain. Prevention efforts targeting individual risk factors as well as contextual social and environmental factors may reduce geographic disparities in childhood and adolescent obesity. JF - Journal of Community Health AU - Singh, Gopal K AU - Kogan, Michael D AU - van Dyck, Peter C AD - Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD, 20857, USA, gsingh@hrsa.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 90 EP - 102 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 33 IS - 2 SN - 0094-5145, 0094-5145 KW - Physical Education Index KW - Obesity KW - Socioeconomic factors KW - Preventive health KW - Community health KW - Analysis KW - Adolescence KW - Television KW - Exercise KW - Children KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20812823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=A+Multilevel+Analysis+of+State+and+Regional+Disparities+in+Childhood+and+Adolescent+Obesity+in+the+United+States&rft.au=Singh%2C+Gopal+K%3BKogan%2C+Michael+D%3Bvan+Dyck%2C+Peter+C&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2008-04-01&rft.volume=33&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-007-9071-7 LA - English DB - Physical Education Index N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Obesity; Adolescence; Children; Socioeconomic factors; Preventive health; Television; Exercise; Analysis; Community health DO - http://dx.doi.org/10.1007/s10900-007-9071-7 ER - TY - JOUR T1 - Nocardia wallacei sp. nov. and Nocardia blacklockiae sp. nov., Human Pathogens and Members of the "Nocardia transvalensis Complex" AN - 20668881; 8200467 AB - Nocardia isolates that share the property of in vitro amikacin resistance are grouped together by some authors in the Nocardia transvalensis complex. Our examination of 13 isolates that are amikacin resistant has revealed the existence of three distinct species. Sequence analysis of the 16S rRNA, 65-kDa heat shock protein, and secA1 genes, coupled with DNA-DNA hybridization, indicated that "N. asteroides drug pattern IV," "N. transvalensis new taxon 1," and N. transvalensis sensu stricto should each be considered a distinct species. The phenotypic and molecular characteristics of the proposed new species Nocardia wallacei (N. asteroides drug pattern IV) and N. blacklockiae (N. transvalensis new taxon 1) are presented and compared with those of N. transvalensis sensu stricto. The relative genetic diversity of isolates best placed with the species N. blacklockiae is also discussed. Case studies demonstrating the pathogenicity of N. wallacei and N. blacklockiae are presented. The type strain of N. wallacei is ATCC 49873 (DSM 45136), and that of N. blacklockiae is ATCC 700035 (DSM 45135). JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Brown, June M AU - Steigerwalt, Arnold G AU - Brown-Elliott, Barbara A AU - Witebsky, Frank G AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland. Bacterial Zoonoses Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia. University of Texas Health Center, Department of Microbiology, Tyler, Texas Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1178 EP - 1184 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 46 IS - 4 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Nocardia transvalensis KW - Heat shock proteins KW - Amikacin KW - Pathogenicity KW - Genetic diversity KW - Pathogens KW - rRNA 16S KW - Drugs KW - New species KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20668881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Nocardia+wallacei+sp.+nov.+and+Nocardia+blacklockiae+sp.+nov.%2C+Human+Pathogens+and+Members+of+the+%22Nocardia+transvalensis+Complex%22&rft.au=Conville%2C+Patricia+S%3BBrown%2C+June+M%3BSteigerwalt%2C+Arnold+G%3BBrown-Elliott%2C+Barbara+A%3BWitebsky%2C+Frank+G&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2008-04-01&rft.volume=46&rft.issue=4&rft.spage=1178&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heat shock proteins; Pathogenicity; Amikacin; Genetic diversity; Pathogens; Drugs; rRNA 16S; New species; Nocardia transvalensis ER - TY - JOUR T1 - Utility of polyclonal antibodies targeted toward unique tryptic peptides in the proteomic analysis of cytochrome P450 isozymes AN - 20589418; 8103602 AB - P450s are key enzymes responsible for biotransformation of numerous endogenous and exogenous compounds and are located in almost every tissue. This superfamily is the largest group of enzymes (>6000) that share a high degree of similarity in protein sequence. The human genome contains 57 CYP genes and 58 pseudogenes. A major gap exists in our knowledge about differences in CYP expression on a protein level. DNA and mRNA information are not sufficient because transcription and particularly translation events are not necessarily correlated with levels of expressed proteins. The data reported in this study complete the framework of an integrated proteomic method for the simultaneous qualitative and quantitative analysis of CYP isozyme composition using MALDI-TOF-MS and immunochemistry that has been developed in our laboratory over the last several years (Alterman et al., 2005a,b) and is based on the fact that each P450 isozyme possesses unique tryptic peptide(s) (UTP) that could be used for differential analysis of human CYP expression. Here we demonstrate that three different immunochemical techniques (ELISA, Western blot, and peptide affinity enrichment on magnetic beads with attached antibodies) have potential to be incorporated in an integrated proteomic method combining mass spectrometry and immunochemistry. Fundamentally, this approach is based on the measurement of the same chemical entity (isozyme-specific UTP) in the tryptic digest by two orthogonal analytical techniques, mass spectrometry and immunochemistry. The application of this approach is illustrated with two human CYP isozymes - CYP1A2 and CYP2E1. JF - Toxicology In Vitro AU - Kornilayev, BA AU - Alterman, MA AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA 8800 Rockville Pike, Building 29A, Room 2D12, HFM-735, Bethesda, MD 20892, United States, Michail.Alterman@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 779 EP - 787 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 22 IS - 3 SN - 0887-2333, 0887-2333 KW - Toxicology Abstracts KW - Genomes KW - Translation KW - Pseudogenes KW - Western blotting KW - Enzyme-linked immunosorbent assay KW - CYP1A2 protein KW - Data processing KW - biotransformation KW - Enzymes KW - Transcription KW - Mass spectroscopy KW - Antibodies KW - Isoenzymes KW - DNA KW - Tryptic peptides KW - Cytochrome P450 KW - proteomics KW - Immunochemistry KW - Amino acid sequence KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20589418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+In+Vitro&rft.atitle=Utility+of+polyclonal+antibodies+targeted+toward+unique+tryptic+peptides+in+the+proteomic+analysis+of+cytochrome+P450+isozymes&rft.au=Kornilayev%2C+BA%3BAlterman%2C+MA&rft.aulast=Kornilayev&rft.aufirst=BA&rft.date=2008-04-01&rft.volume=22&rft.issue=3&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Toxicology+In+Vitro&rft.issn=08872333&rft_id=info:doi/10.1016%2Fj.tiv.2007.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Western blotting; Pseudogenes; Translation; Enzyme-linked immunosorbent assay; Data processing; CYP1A2 protein; biotransformation; Transcription; Enzymes; Mass spectroscopy; Antibodies; DNA; Isoenzymes; Tryptic peptides; proteomics; Cytochrome P450; Immunochemistry; Amino acid sequence DO - http://dx.doi.org/10.1016/j.tiv.2007.12.001 ER - TY - JOUR T1 - O Antigen Protects Bordetella parapertussis from Complement AN - 20542887; 8086180 AB - Bordetella pertussis, a causative agent of whooping cough, expresses BrkA, which confers serum resistance, but the closely related human pathogen that also causes whooping cough, Bordetella parapertussis, does not. Interestingly, B. parapertussis, but not B. pertussis, produces an O antigen, a factor shown in other models to confer serum resistance. Using a murine model of infection, we determined that O antigen contributes to the ability of B. parapertussis to colonize the respiratory tract during the first week of infection, but not thereafter. Interestingly, an O antigen-deficient strain of B. parapertussis was not defective in colonizing mice lacking the complement cascade. O antigen prevented both complement component C3 deposition on the surface and complement-mediated killing of B. parapertussis. In addition, O antigen was required for B. parapertussis to systemically spread in complement-sufficient mice, but not complement-deficient mice. These data indicate that O antigen enables B. parapertussis to efficiently colonize the lower respiratory tract by protecting against complement-mediated control and clearance. JF - Infection and Immunity AU - Goebel, Elizabeth M AU - Wolfe, Daniel N AU - Elder, Kelly AU - Stibitz, Scott AU - Harvill, Eric T AD - Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Building, University Park, Pennsylvania 16802. Graduate Program in Immunology and Infectious Diseases. Graduate Program in Pathobiology. Center for Biologics Evaluation and Research, FDA, 29 Lincoln Drive, Bethesda, Maryland 20892 Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1774 EP - 1780 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 4 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Pertussis KW - Bordetella pertussis KW - Complement KW - Bordetella parapertussis KW - Animal models KW - O antigen KW - Complement component C3 KW - Pathogens KW - Infection KW - Respiratory tract KW - Models KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20542887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=O+Antigen+Protects+Bordetella+parapertussis+from+Complement&rft.au=Goebel%2C+Elizabeth+M%3BWolfe%2C+Daniel+N%3BElder%2C+Kelly%3BStibitz%2C+Scott%3BHarvill%2C+Eric+T&rft.aulast=Goebel&rft.aufirst=Elizabeth&rft.date=2008-04-01&rft.volume=76&rft.issue=4&rft.spage=1774&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pertussis; Complement; Animal models; O antigen; Complement component C3; Pathogens; Infection; Models; Respiratory tract; Bordetella pertussis; Bordetella parapertussis ER - TY - JOUR T1 - Aflatoxins contamination in spices and processed spice products commercialized in Korea AN - 20468304; 7916626 AB - A survey for total aflatoxins (aflatoxins B1, B2, G1, and G2) was conducted on 88 spices and processed spice products commercialized in Korea. The presence of aflatoxins was determined by high-performance liquid chromatography (HPLC) with fluorescence detector using immunoaffinity column clean-up. Total aflatoxins (AFs) are detected in 12 samples (13.6% of incidence) including seven red pepper powder, two red pepper pastes (Kochujang), two curry and one ginger product. The contamination levels are 0.08-4.45 is a subset of g/kg as aflatoxin B1 and 0.08-4.66 is a subset of g/kg as AFs. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis on contaminated samples was conducted for the confirmation of detected aflatoxins. The 12 samples which showed aflatoxins by HPLC/FLD were confirmed as aflatoxins by LC-MS/MS. JF - Food Chemistry AU - Cho, Sung-Hye AU - Lee, Chang-Hee AU - Jang, Mi-Ran AU - Son, Young-Wook AU - Lee, Sang-Mok AU - Choi, In-Sun AU - Kim, So-Hee AU - Kim, Dai-Byung AD - Busan Regional Agency, Korea Food and Drug Administration, Busan 608-829, Republic of Korea, chang65@hanmail.net Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1283 EP - 1288 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 107 IS - 3 SN - 0308-8146, 0308-8146 KW - Toxicology Abstracts KW - Aflatoxins KW - Spices KW - Immunoaffinity column KW - HPLC-FLD KW - LC-MS/MS KW - High-performance liquid chromatography KW - Aflatoxin B1 KW - Powder KW - Fluorescence KW - Food contamination KW - Mass spectroscopy KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20468304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Chemistry&rft.atitle=Aflatoxins+contamination+in+spices+and+processed+spice+products+commercialized+in+Korea&rft.au=Cho%2C+Sung-Hye%3BLee%2C+Chang-Hee%3BJang%2C+Mi-Ran%3BSon%2C+Young-Wook%3BLee%2C+Sang-Mok%3BChoi%2C+In-Sun%3BKim%2C+So-Hee%3BKim%2C+Dai-Byung&rft.aulast=Cho&rft.aufirst=Sung-Hye&rft.date=2008-04-01&rft.volume=107&rft.issue=3&rft.spage=1283&rft.isbn=&rft.btitle=&rft.title=Food+Chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2007.08.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Aflatoxin B1; High-performance liquid chromatography; Powder; Fluorescence; Spices; Aflatoxins; Food contamination; Mass spectroscopy DO - http://dx.doi.org/10.1016/j.foodchem.2007.08.049 ER - TY - JOUR T1 - Mortality among U.S. underground coal miners: A 23-year follow-up AN - 20278308; 8891653 AB - Background The mortality experience over 22-24 years of 8,899 working coal miners initially medically examined in 1969-1971 at 31 U.S. coal mines was evaluated. Methods A cohort life-table analysis was undertaken on underlying causes of death, and proportional hazards models were fitted to both underlying, and underlying and contributing causes of death. Results Elevated mortality from nonviolent causes, nonmalignant respiratory disease (NMRD), and accidents was observed, but lung cancer and stomach cancer mortality were not elevated. Smoking, pneumoconiosis, coal rank region, and cumulative coal mine dust exposure were all predictors of mortality from nonviolent causes and NMRD. Mortality from nonviolent causes and NMRD was related to dust exposure within the complete cohort and also for the never smoker subgroup. Dust exposure relative risks for mortality were similar for pneumoconiosis, NMRD, and chronic airways obstruction. Conclusions The findings confirm and enlarge upon previous results showing that exposure to coal mine dust leads to increased mortality, even in the absence of smoking. Am. J. Ind. Med. 51:231-245, 2008. JF - American Journal of Industrial Medicine AU - Attfield, M D AU - Kuempel, E D AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, mdal@cdc.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 231 EP - 245 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 51 IS - 4 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Occupational safety KW - Pneumoconiosis KW - Coal KW - Respiratory diseases KW - Mines KW - Dust KW - Cancer KW - Smoking KW - USA KW - Accidents KW - Mining KW - Lung cancer KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20278308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Mortality+among+U.S.+underground+coal+miners%3A+A+23-year+follow-up&rft.au=Attfield%2C+M+D%3BKuempel%2C+E+D&rft.aulast=Attfield&rft.aufirst=M&rft.date=2008-04-01&rft.volume=51&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20560 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoking; Mortality; Accidents; Occupational safety; Pneumoconiosis; Respiratory diseases; Mining; Coal; Mines; Cancer; Dust; Lung cancer; USA DO - http://dx.doi.org/10.1002/ajim.20560 ER - TY - JOUR T1 - Nutrigenomics research for personalized nutrition and medicine AN - 20269717; 8853264 AB - Current nutritional and genetic epidemiological methods yield 'risk factors' on the basis of population studies. Risk factors, however, are statistical estimates of the percentage reduction in disease in the population if the risk were to be avoided or the gene variant were not present. These measures are often assumed to apply to individuals who are likely to differ in genetic make-up, lifestyle, and dietary patterns than to the individuals in the study population. Developing individual risk factors in light of the genetic diversity of human populations, the complexity of foods, culture and lifestyle, and the variety of metabolic processes that lead to health or disease is a significant challenge for personalizing dietary advice for healthy or individuals with chronic disease. JF - Current Opinion in Biotechnology AU - Kaput, Jim AD - Division of Personalized Nutrition and Medicine, FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States, James.Kaput@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 110 EP - 120 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 19 IS - 2 SN - 0958-1669, 0958-1669 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Statistics KW - Risk factors KW - Reviews KW - Food KW - Population studies KW - Genetic diversity KW - Nutrition KW - W 30910:Imaging KW - G 07750:Ecological & Population Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20269717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Nutrigenomics+research+for+personalized+nutrition+and+medicine&rft.au=Kaput%2C+Jim&rft.aulast=Kaput&rft.aufirst=Jim&rft.date=2008-04-01&rft.volume=19&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2008.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Statistics; Food; Reviews; Risk factors; Genetic diversity; Population studies; Nutrition DO - http://dx.doi.org/10.1016/j.copbio.2008.02.005 ER - TY - JOUR T1 - Investigational new drugs submitted to the Food and Drug Administration that are placed on clinical hold: the experience of the Office of Cellular, Tissue and Gene Therapy AN - 20133764; 10252889 AB - Background Cell and gene therapies are medical products regulated by the U.S. Food and Drug Administration (FDA) within its Center of Biologics Evaluation and Research (CBER) in the Office of Cellular, Tissue, and Gene Therapy (OCTGT). Clinical research using cell and gene therapies in the United States must be conducted under an Investigational New Drug (IND) application. After an initial, 30-day review FDA either places an IND on clinical hold or allows the IND to proceed. Methods We reviewed letters sent by OCTGT to IND sponsors that were placed on clinical hold. We categorized each deficiency and determined its frequency. Results We found that similar deficiencies existed across IND applications and we tabulated the most common deficiencies. Discussion We discussed the deficiencies and the resources that can help individuals avoid those deficiencies. We believe that awareness of the common deficiencies along with the applicable resources can reduce the frequency of clinical holds and allow clinical studies to proceed without delay. We also believe that this information will guide the FDA as to how to facilitate development of safe and effective cell and gene therapies. JF - Cytotherapy AU - Wonnacott, K AU - Lavoie, D AU - Fiorentino, R AU - McIntyre, M AU - Huang, Y AU - Hirschfeld, S AD - Food and Drug Administration, Center for Biologics Evaluation and Research, Rockville, Maryland, USA Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 312 EP - 316 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 10 IS - 3 SN - 1465-3249, 1465-3249 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene therapy KW - Medical equipment KW - Reviews KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20133764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytotherapy&rft.atitle=Investigational+new+drugs+submitted+to+the+Food+and+Drug+Administration+that+are+placed+on+clinical+hold%3A+the+experience+of+the+Office+of+Cellular%2C+Tissue+and+Gene+Therapy&rft.au=Wonnacott%2C+K%3BLavoie%2C+D%3BFiorentino%2C+R%3BMcIntyre%2C+M%3BHuang%2C+Y%3BHirschfeld%2C+S&rft.aulast=Wonnacott&rft.aufirst=K&rft.date=2008-04-01&rft.volume=10&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Cytotherapy&rft.issn=14653249&rft_id=info:doi/10.1080%2F14653240801910905 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Gene therapy; Medical equipment; Reviews DO - http://dx.doi.org/10.1080/14653240801910905 ER - TY - JOUR T1 - Digital-analog hybrid control model for eukaryotic heat shock response illustrating the dynamics of heat shock protein 70 on exposure to thermal stress AN - 19920306; 8688846 AB - We are introducing in this paper a digital-analog hybrid model approach for the study of a complete gene regulatory network; the heat shock response (HSR) network of eukaryotes. HSR is a crucial and widely studied cellular phenomenon occurring due to various stresses on the cell, and is characterised by the induction of heat shock genes resulting in the production of heat shock proteins (HSPs) which restores cellular homeostasis by maintaining protein integrity. We are proposing a model which incorporates simple digital and analog components which mimic the functioning of biological molecules involved in HSR and model their dynamics and behaviour. The simulation result of the circuit for the production of HSP70 has been found to be consistent with published experimental results. The qualitative behaviour of the HSR is expressed through a truth table. Through this novel approach, the authors have tried to develop a level of understanding of the interactions of the parts of the HSR system and of this system as a whole. JF - Computer Methods and Programs in Biomedicine AU - Dwivedi, Anjana AU - Karan, Bhuwan Mohan AU - Das, Barda Nand AU - Sinha, Rakesh Kumar AD - Department of Electrical and Electronics Engineering, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India, dwivedi.anjana@gmail.com Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 17 EP - 24 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo@elsevier.com], [URL:http://www.elsevier.nl] VL - 90 IS - 1 SN - 0169-2607, 0169-2607 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Digital-analog hybrid model KW - Gene regulatory network KW - Heat shock response KW - Heat shock protein 70 KW - Molecular modelling KW - Heat shock proteins KW - Hsp70 protein KW - Hybrids KW - Stress KW - Circuits KW - Homeostasis KW - Computer applications KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19920306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Methods+and+Programs+in+Biomedicine&rft.atitle=Digital-analog+hybrid+control+model+for+eukaryotic+heat+shock+response+illustrating+the+dynamics+of+heat+shock+protein+70+on+exposure+to+thermal+stress&rft.au=Dwivedi%2C+Anjana%3BKaran%2C+Bhuwan+Mohan%3BDas%2C+Barda+Nand%3BSinha%2C+Rakesh+Kumar&rft.aulast=Dwivedi&rft.aufirst=Anjana&rft.date=2008-04-01&rft.volume=90&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Computer+Methods+and+Programs+in+Biomedicine&rft.issn=01692607&rft_id=info:doi/10.1016%2Fj.cmpb.2007.11.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Heat shock proteins; Hsp70 protein; Hybrids; Stress; Circuits; Homeostasis; Computer applications DO - http://dx.doi.org/10.1016/j.cmpb.2007.11.008 ER - TY - JOUR T1 - Detection of naturally occurring enteroviruses in waters using direct RT-PCR and integrated cell culture-RT-PCR AN - 19682434; 8245652 AB - Viruses detected by rapid molecular assays are not always infectious. In this study we compared enterovirus levels in natural waters using culture and reverse transcription-polymerase chain reaction (RT-PCR) techniques to determine whether molecular units of naturally occurring enteroviruses can be utilized to predict viral infectivity. Viruses were concentrated from 12 river water and effluent samples using 1MDS filter-filtration and beef extract-elution. An integrated cell culture-RT-PCR (ICC-RT-PCR) was applied to the concentrates; and these waters contained up to 1.9MPN of culturable (on BGM cells) viruses per litre (0.57MPN /300ml). Sample concentrates were also subjected to a direct 'molecular' approach using solvent-extraction, PEG-precipitation, and RNA-extraction before RT-PCR detection. The detection sensitivity of the direct RT-PCR was equivalent to 0.46 estimated (culturable) MPN/reaction, per 300ml water. Two-thirds of the samples demonstrated consistent presence or absence of viruses by ICC-RT-PCR and direct RT-PCR. The direct RT-PCR approach resulted in over-estimation of naturally occurring infectious viruses as high as 91-fold in waters. Increased RT-PCR units may not reflect higher levels of culturable viruses in natural waters. The differences in virus levels detected by molecular and culture assays could be attributed to factors of volume of sample analyzed, different concentration schemes utilized that may affect the presence of residual inhibitors, and different stability exhibited by enterovirus strains/groups. JF - Journal of Virological Methods AU - Shieh, Y C AU - Wong, C I AU - Krantz, JA AU - Hsu, F C AD - Dauphin Island, AL 36528, USA, carol.shieh@fda.hhs.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 184 EP - 189 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 149 IS - 1 SN - 0166-0934, 0166-0934 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Rivers KW - Infectivity KW - Enterovirus KW - Beef KW - Polymerase chain reaction KW - Cell culture KW - Effluents KW - V 22300:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19682434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Detection+of+naturally+occurring+enteroviruses+in+waters+using+direct+RT-PCR+and+integrated+cell+culture-RT-PCR&rft.au=Shieh%2C+Y+C%3BWong%2C+C+I%3BKrantz%2C+JA%3BHsu%2C+F+C&rft.aulast=Shieh&rft.aufirst=Y&rft.date=2008-04-01&rft.volume=149&rft.issue=1&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2007.12.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Rivers; Infectivity; Beef; Polymerase chain reaction; Cell culture; Effluents; Enterovirus DO - http://dx.doi.org/10.1016/j.jviromet.2007.12.013 ER - TY - JOUR T1 - Occupational Risk Management of Engineered Nanoparticles AN - 19582969; 8502054 AB - The earliest and most extensive societal exposures to engineered nanoparticles are likely to occur in the workplace. Until toxicologic and health effects research moves forward to characterize more broadly the potential hazards of nanoparticles and to provide a scientific basis for appropriate control of nanomaterials in the workplace, current and future workers may be at risk from occupational exposures. This article reviews a conceptual framework for occupational risk management as applied to engineered nanomaterials and describes an associated approach for controlling exposures in the presence of uncertainty. The framework takes into account the potential routes of exposure and factors that may influence biological activity and potential toxicity of nanomaterials; incorporates primary approaches based on the traditional industrial hygiene hierarchy of controls involving elimination or substitution, engineering controls, administrative controls, and use of personal protective equipment; and includes valuable secondary approaches involving health surveillance and medical monitoring. JF - Journal of Occupational and Environmental Hygiene AU - Schulte, Paul AU - Geraci, Charles AU - Zumwalde, Ralph AU - Hoover, Mark AU - Kuempel, Eileen AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 239 EP - 249 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 4 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Toxicity KW - Protective equipment KW - Workers KW - Reviews KW - Hygiene KW - nanoparticles KW - Occupational exposure KW - nanotechnology KW - Environmental hygiene KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19582969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Occupational+Risk+Management+of+Engineered+Nanoparticles&rft.au=Schulte%2C+Paul%3BGeraci%2C+Charles%3BZumwalde%2C+Ralph%3BHoover%2C+Mark%3BKuempel%2C+Eileen&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2008-04-01&rft.volume=5&rft.issue=4&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620801907840 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Workers; Toxicity; Hygiene; nanoparticles; Occupational exposure; Environmental hygiene; Reviews; Protective equipment; nanotechnology DO - http://dx.doi.org/10.1080/15459620801907840 ER - TY - JOUR T1 - Suspension Tolerance in a Full-Body Safety Harness, and a Prototype Harness Accessory AN - 19578362; 8502052 AB - Workers wearing full-body safety harnesses are at risk for suspension trauma if they are not rescued in 5 to 30 min after a successfully arrested fall. Suspension trauma, which may be fatal, occurs when a person's legs are immobile in a vertical posture, leading to the pooling of blood in the legs, pelvis, and abdomen, and the reduction of return blood flow to the heart and brain. To measure suspension tolerance time, 22 men and 18 women with construction experience were suspended from the chest D-ring (CHEST) and back D-ring (BACK) of full-body, fall-arrest harnesses. Fifteen men and 13 women from the original group of subjects were then suspended using a newly developed National Institute for Occupational Safety and Health harness accessory (ACCESS), which supports the upper legs. Midthigh circumference changes were 1.4 and 1.9 cm, changes in minute ventilation were 1.2 and 1.5 L/min, changes in heart rate (HR) were 15.1 and 21.6 bpm, and changes in mean arterial pressure were 5.1 and -2.6 mmHg (p <= 0.05) for all subjects during CHEST and BACK, respectively. Kaplan-Meier median suspension time for all subjects for the CHEST condition was 29 min (range 4-60 min) and 31 min (range 5-56 min) for the BACK condition. The 95th percentile for suspension time was 7 min for CHEST and 11 min for BACK. Cox regression revealed that body weight had a statistically significant effect on the time until experiencing a medical end point (p <= 0.05) during the BACK condition. Mean (± SD) suspension time was 58 ± 6 min (range 39-60 min) for all subjects for the ACCESS condition. There were no terminations due to medical symptoms during the ACCESS suspension, changes in physiological variables were small, and 85% of ACCESS subjects completed 60-min suspensions. These data provide information on motionless suspension tolerance time to standards-setting organizations and demonstrate the potential of a prototype harness accessory to delay or prevent suspension trauma. JF - Journal of Occupational and Environmental Hygiene AU - Turner, Nina L AU - Wassell, James T AU - Whisler, Richard AU - Zwiener, Joyce AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 227 EP - 231 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 4 SN - 1545-9624, 1545-9624 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Ventilation KW - Prototypes KW - prototypes KW - Heart rate KW - Physiology KW - Occupational safety KW - Brain KW - Protective equipment KW - Body weight KW - heart rate KW - Posture KW - body weight KW - posture KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19578362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Suspension+Tolerance+in+a+Full-Body+Safety+Harness%2C+and+a+Prototype+Harness+Accessory&rft.au=Turner%2C+Nina+L%3BWassell%2C+James+T%3BWhisler%2C+Richard%3BZwiener%2C+Joyce&rft.aulast=Turner&rft.aufirst=Nina&rft.date=2008-04-01&rft.volume=5&rft.issue=4&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620801894386 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ventilation; Prototypes; prototypes; Occupational safety; Physiology; Heart rate; Brain; Protective equipment; Body weight; heart rate; Posture; body weight; posture DO - http://dx.doi.org/10.1080/15459620801894386 ER - TY - JOUR T1 - In Vitro Model of Colonization Resistance by the Enteric Microbiota: Effects of Antimicrobial Agents Used in Food-Producing Animals AN - 19528728; 8083436 AB - A bioassay was developed to measure the minimum concentration of an antimicrobial drug that disrupts the colonization resistance mediated by model human intestinal microbiota against Salmonella invasion of Caco-2 intestinal cells. The bioassay was used to measure the minimum disruptive concentrations (MDCs) of drugs used in animal agriculture. The MDCs varied from 0.125 mu g/ml for some broad-spectrum antimicrobial drugs (e.g., streptomycin) to 16 mu g/ml for drugs with limited spectra of antimicrobial activity (e.g., lincomycin). The acceptable daily intake (ADI) residue concentration calculated on the basis of the MDCs were higher for erythromycin, lincomycin, and tylosin than the ADI residue concentrations calculated on the basis of the MICs. The MDC-based ADI values for apramycin, bacitracin, neomycin, novobiocin, penicillin G, streptomycin, tetracycline, and vancomycin were lower than the reported MIC-based ADI values. The effects of antimicrobial drugs at their MDCs on the bacterial composition of the microbiota were observed by denaturing gradient gel electrophoresis of 16S rRNA sequences amplified by PCR. Changes in the population composition of the model colonization resistance microbiota occurred simultaneously with reduced colonization resistance. The results of this study suggest that direct assessment of the effects of antimicrobial drugs on colonization resistance in an in vitro model can be useful in determining ADI values. JF - Antimicrobial Agents & Chemotherapy AU - Wagner, RDoug AU - Johnson, Shemedia J AU - Cerniglia, Carl E AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1230 EP - 1237 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 4 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Agriculture KW - Antimicrobial activity KW - Drug resistance KW - Food KW - Streptomycin KW - Bacitracin KW - Tetracyclines KW - Colonization KW - Polymerase chain reaction KW - Vancomycin KW - Neomycin KW - Drugs KW - Novobiocin KW - Lincomycin KW - Apramycin KW - Erythromycin KW - Minimum inhibitory concentration KW - Penicillin KW - Gel electrophoresis KW - Antimicrobial agents KW - Intestinal microflora KW - Intestine KW - Tylosin KW - Salmonella KW - rRNA 16S KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19528728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Model+of+Colonization+Resistance+by+the+Enteric+Microbiota%3A+Effects+of+Antimicrobial+Agents+Used+in+Food-Producing+Animals&rft.au=Wagner%2C+RDoug%3BJohnson%2C+Shemedia+J%3BCerniglia%2C+Carl+E&rft.aulast=Wagner&rft.aufirst=RDoug&rft.date=2008-04-01&rft.volume=52&rft.issue=4&rft.spage=1230&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Agriculture; Antimicrobial activity; Food; Drug resistance; Novobiocin; Lincomycin; Bacitracin; Streptomycin; Apramycin; Tetracyclines; Erythromycin; Minimum inhibitory concentration; Gel electrophoresis; Penicillin; Antimicrobial agents; Intestinal microflora; Colonization; Intestine; Vancomycin; Polymerase chain reaction; Neomycin; Tylosin; rRNA 16S; Drugs; Salmonella ER - TY - JOUR T1 - Population Structure of Invasive and Colonizing Strains of Streptococcus agalactiae from Neonates of Six U.S. Academic Centers from 1995 to 1999 AN - 19480676; 8200483 AB - The purpose of this study was to describe the population structure of group B streptococci (GBS) isolated from infected and colonized neonates during a prospective active-surveillance study of early-onset disease in six centers in the United States from July 1995 to June 1999 and to examine its relationship to bovine strains of GBS. The phylogenetic lineage of each GBS isolate was determined by multilocus sequence typing, and isolates were clustered into clonal complexes (CCs) using the eBURST software program. A total of 899 neonatal GBS isolates were studied, of which 129 were associated with invasive disease. Serotype Ia, Ib, and V isolates were highly clonal, with 92% to 96% of serotype Ia, Ib, and V isolates being confined to single clonal clusters. In contrast, serotype II and III isolates were each comprised of two major clones, with 39% of serotype II and 41% of serotype III isolates in CC 17 and 41% of serotype II and 54% of serotype III isolates in CC 19. Further analysis demonstrates that the CC 17 serotype II and III GBS are closely related to a previously described "ancestral" lineage of bovine GBS. While 120 (93%) of invasive GBS were confined to the same lineages that colonized neonates, 9 (7%) of the invasive GBS isolates were from rare lineages that comprised only 2.7% of colonizing lineages. These results are consistent with those for other geographic regions that demonstrate the highly clonal nature of GBS infecting and colonizing human neonates. JF - Journal of Clinical Microbiology AU - Bohnsack, John F AU - Whiting, April AU - Gottschalk, Marcelo AU - Dunn, Diane Marie AU - Weiss, Robert AU - Azimi, Parvin H AU - Philips, Joseph BIII AU - Weisman, Leonard E AU - Rhoads, George G AU - Lin, Feng-Ying C AD - Department of Pediatrics. Genome Center, University of Utah Health Sciences Center, Salt Lake City, Utah. Faculte de Medicine Veterinaire, Universite de Montreal, Saint-Hyacinthe, Quebec, Canada. Department of Infectious Diseases, Children's Hospital Medical Center of Northern California, Oakland, California. University of Alabama at Birmingham, Birmingham, Alabama. Baylor College of Medicine, Houston, Texas. University of Dentistry and Medicine of New Jersey, Piscataway, New Jersey. National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1285 EP - 1291 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 46 IS - 4 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Computer programs KW - software KW - Age KW - Serotypes KW - Guillain-Barre syndrome KW - Streptococcus agalactiae KW - Population structure KW - Neonates KW - multilocus sequence typing KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19480676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Population+Structure+of+Invasive+and+Colonizing+Strains+of+Streptococcus+agalactiae+from+Neonates+of+Six+U.S.+Academic+Centers+from+1995+to+1999&rft.au=Bohnsack%2C+John+F%3BWhiting%2C+April%3BGottschalk%2C+Marcelo%3BDunn%2C+Diane+Marie%3BWeiss%2C+Robert%3BAzimi%2C+Parvin+H%3BPhilips%2C+Joseph+BIII%3BWeisman%2C+Leonard+E%3BRhoads%2C+George+G%3BLin%2C+Feng-Ying+C&rft.aulast=Bohnsack&rft.aufirst=John&rft.date=2008-04-01&rft.volume=46&rft.issue=4&rft.spage=1285&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phylogeny; Computer programs; Age; software; Serotypes; Guillain-Barre syndrome; Population structure; Neonates; multilocus sequence typing; Streptococcus agalactiae ER - TY - JOUR T1 - Semicarbazide formation in flour and bread. AN - 70414345; 18303820 AB - Azodicarbonamide, an approved food additive, is commonly used as a flour additive and dough conditioner in the United States and Canada. A number of researchers have clearly established a link between the use of azodicarbonamide and semicarbazide contamination in commercial bread products. However, all of these studies have primarily focused on the final baked product and have not extensively investigated the processing and conditions that affect the final semicarbazide levels. In this study, a previously developed method for measuring free semicarbazide in bread was applied to dough samples during the mixing and kneading process. Additionally, flour and bread samples were spiked with biurea or azodicarbonamide to help elucidate semicarbazide formation pathways. The results showed that semicarbazide was not formed as a byproduct of azodicarbonamide decomposition to biurea, which occurs upon the addition of water. Indeed, semicarbazide was not detected after room temperature or elevated temperature dough maturation, but only after baking. It was concluded that although azodicarbonamide is the initial starting material, semicarbazide formation in bread occurs through a stable intermediate, biurea. JF - Journal of agricultural and food chemistry AU - Noonan, Gregory O AU - Begley, Timothy H AU - Diachenko, Gregory W AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. gregory.noonan@fda.hhs.gov Y1 - 2008/03/26/ PY - 2008 DA - 2008 Mar 26 SP - 2064 EP - 2067 VL - 56 IS - 6 SN - 0021-8561, 0021-8561 KW - Azo Compounds KW - 0 KW - Biureas KW - Food Additives KW - Semicarbazides KW - 1,1-azobisformamide KW - 56Z28B9C8O KW - Index Medicus KW - Hot Temperature KW - Azo Compounds -- chemistry KW - Food Additives -- chemistry KW - Food Contamination -- analysis KW - Food Handling KW - Biureas -- chemistry KW - Flour -- analysis KW - Semicarbazides -- chemical synthesis KW - Semicarbazides -- analysis KW - Bread -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70414345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Semicarbazide+formation+in+flour+and+bread.&rft.au=Noonan%2C+Gregory+O%3BBegley%2C+Timothy+H%3BDiachenko%2C+Gregory+W&rft.aulast=Noonan&rft.aufirst=Gregory&rft.date=2008-03-26&rft.volume=56&rft.issue=6&rft.spage=2064&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf073198g LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-11 N1 - Date created - 2008-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf073198g ER - TY - JOUR T1 - Strategic paths for biomarker qualification AN - 20664736; 8185027 AB - Biomarkers may be qualified using different qualification processes. A passive approach for qualification has been to accept the end of discussions in the scientific literature as an indication that a biomarker has been accepted. An active approach to qualification requires development of a comprehensive process by which a consensus may be reached about the qualification of a biomarker. Active strategies for qualification include those associated with context-independent as well as context-dependent qualifications. JF - Toxicology AU - Goodsaid, F M AU - Frueh, F W AU - Mattes, W AD - Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, FDA, United States, Federico.Goodsaid@fda.hhs.gov Y1 - 2008/03/20/ PY - 2008 DA - 2008 Mar 20 SP - 219 EP - 223 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 245 IS - 3 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20664736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Strategic+paths+for+biomarker+qualification&rft.au=Goodsaid%2C+F+M%3BFrueh%2C+F+W%3BMattes%2C+W&rft.aulast=Goodsaid&rft.aufirst=F&rft.date=2008-03-20&rft.volume=245&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2007.12.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/j.tox.2007.12.023 ER - TY - CPAPER T1 - Zinc Diethyldithiocarbamate Allergenicity: Potential Haptenation Mechanisms. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40859512; 4813185 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Chipinda, I AU - Hettick, J M AU - Simoyi, R H AU - Siegel, P D Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Zinc KW - Allergenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Zinc+Diethyldithiocarbamate+Allergenicity%3A+Potential+Haptenation+Mechanisms.&rft.au=Chipinda%2C+I%3BHettick%2C+J+M%3BSimoyi%2C+R+H%3BSiegel%2C+P+D&rft.aulast=Chipinda&rft.aufirst=I&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Labeled Single Walled Carbon Nanotubes to Study Acute Translocation from the Lungs. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40859347; 4813171 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Mercer, R R AU - Scabilloni, J F AU - Wang, L AU - Battelli, L A AU - Castranova, V Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Translocation KW - Lung KW - Nanotechnology KW - Carbon KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Use+of+Labeled+Single+Walled+Carbon+Nanotubes+to+Study+Acute+Translocation+from+the+Lungs.&rft.au=Mercer%2C+R+R%3BScabilloni%2C+J+F%3BWang%2C+L%3BBattelli%2C+L+A%3BCastranova%2C+V&rft.aulast=Mercer&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of an Improved Strategy for the Derivation of Skin Notations T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40859022; 4813078 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Dotson, G AU - Maier, A AU - Gadagbui, B AU - Geraci, C L Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Development+of+an+Improved+Strategy+for+the+Derivation+of+Skin+Notations&rft.au=Dotson%2C+G%3BMaier%2C+A%3BGadagbui%2C+B%3BGeraci%2C+C+L&rft.aulast=Dotson&rft.aufirst=G&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumors Derived from Many Different Tissues may have Polyclonal Origin: Evidence and Implications. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858987; 4813246 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Parsons, B L Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Tumors+Derived+from+Many+Different+Tissues+may+have+Polyclonal+Origin%3A+Evidence+and+Implications.&rft.au=Parsons%2C+B+L&rft.aulast=Parsons&rft.aufirst=B&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risk Assessment of Acrylamide in Food Contact Materials. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858885; 4813232 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Henry, S H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Risk assessment KW - Acrylamide KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Risk+Assessment+of+Acrylamide+in+Food+Contact+Materials.&rft.au=Henry%2C+S+H&rft.aulast=Henry&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Defining Neuroinflammation: Lessons from MPTP- and Methamphetamine-Induced Neurotoxicity. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858802; 4813092 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - O'Callaghan, J P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Neurotoxicity KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Defining+Neuroinflammation%3A+Lessons+from+MPTP-+and+Methamphetamine-Induced+Neurotoxicity.&rft.au=O%27Callaghan%2C+J+P&rft.aulast=O%27Callaghan&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Year of Biomarker Qualification Submissions through the Pilot Process for Biomarker Qualification at the FDA. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858299; 4813338 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Goodsaid, F M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Bioindicators KW - FDA KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=A+Year+of+Biomarker+Qualification+Submissions+through+the+Pilot+Process+for+Biomarker+Qualification+at+the+FDA.&rft.au=Goodsaid%2C+F+M&rft.aulast=Goodsaid&rft.aufirst=F&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Endotoxin-induced Acute Kidney Injury in Rats. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858163; 4812976 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Brown, R P AU - Vaidya, V S AU - Beach, B C AU - Toal, M C AU - Loftin, S T AU - Zhang, J AU - Collings, F B AU - Bonventre, J V AU - Goering, P L Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Kidneys KW - Injuries KW - Rats KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Detection+of+Endotoxin-induced+Acute+Kidney+Injury+in+Rats.&rft.au=Brown%2C+R+P%3BVaidya%2C+V+S%3BBeach%2C+B+C%3BToal%2C+M+C%3BLoftin%2C+S+T%3BZhang%2C+J%3BCollings%2C+F+B%3BBonventre%2C+J+V%3BGoering%2C+P+L&rft.aulast=Brown&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Independently Public Toxicogenomics Studies Validate the Transsulfuation Pathway as Potential Liver Toxicity Pathway. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40857710; 4813110 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Chen, M AU - Schnackenberg, L K AU - Holland, R AU - Beger, R D AU - Isukapalli, S AU - Georgopoulos, P G AU - Welsh, W J AU - Tong, W Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Liver KW - Animal physiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Independently+Public+Toxicogenomics+Studies+Validate+the+Transsulfuation+Pathway+as+Potential+Liver+Toxicity+Pathway.&rft.au=Chen%2C+M%3BSchnackenberg%2C+L+K%3BHolland%2C+R%3BBeger%2C+R+D%3BIsukapalli%2C+S%3BGeorgopoulos%2C+P+G%3BWelsh%2C+W+J%3BTong%2C+W&rft.aulast=Chen&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contaminants and a Globilized Food Supply. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40857633; 4813231 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Bolger, P M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Contaminants KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Contaminants+and+a+Globilized+Food+Supply.&rft.au=Bolger%2C+P+M&rft.aulast=Bolger&rft.aufirst=P&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Irritancy and the Sensitization Potential of Metal Working Fluids and Metal Working Fluid Components. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40856615; 4813182 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Anderson, S AU - Brown, K AU - Butterworth, L AU - Fedorowicz, A AU - Beezhold, D AU - Munson, A E AU - Meade, B J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Metals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Evaluation+of+Irritancy+and+the+Sensitization+Potential+of+Metal+Working+Fluids+and+Metal+Working+Fluid+Components.&rft.au=Anderson%2C+S%3BBrown%2C+K%3BButterworth%2C+L%3BFedorowicz%2C+A%3BBeezhold%2C+D%3BMunson%2C+A+E%3BMeade%2C+B+J&rft.aulast=Anderson&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Biodistribution of Coated and Uncoated Nano- and Micron-Sized Titanium Dioxide Following Intradermal Administration in Mice. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40856470; 4813175 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Gopee, N V AU - Cozart, C AU - Siitonen, P H AU - Smith, C S AU - Walker, N J AU - Howard, P C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Titanium dioxide KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Comparative+Biodistribution+of+Coated+and+Uncoated+Nano-+and+Micron-Sized+Titanium+Dioxide+Following+Intradermal+Administration+in+Mice.&rft.au=Gopee%2C+N+V%3BCozart%2C+C%3BSiitonen%2C+P+H%3BSmith%2C+C+S%3BWalker%2C+N+J%3BHoward%2C+P+C&rft.aulast=Gopee&rft.aufirst=N&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in the Renal Expression of RPA-1, RPA-2, and KIM-1 from Spontaneously Hypertensive Rats (SHR) Given Doxorubicin (DXR) or Mitoxantrone (MTX), with or without Dexrazoxane (DRZ). T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40856186; 4812986 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Zhang, J AU - Shaw, M AU - Keenan, J AU - Kilty, C AU - Lipshultz, S E AU - Knapton, A AU - Vaidya, V S AU - Bonventre, J V AU - Herman, E H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Rats KW - Doxorubicin KW - Razoxane KW - Kidneys KW - Mitoxantrone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Changes+in+the+Renal+Expression+of+RPA-1%2C+RPA-2%2C+and+KIM-1+from+Spontaneously+Hypertensive+Rats+%28SHR%29+Given+Doxorubicin+%28DXR%29+or+Mitoxantrone+%28MTX%29%2C+with+or+without+Dexrazoxane+%28DRZ%29.&rft.au=Zhang%2C+J%3BShaw%2C+M%3BKeenan%2C+J%3BKilty%2C+C%3BLipshultz%2C+S+E%3BKnapton%2C+A%3BVaidya%2C+V+S%3BBonventre%2C+J+V%3BHerman%2C+E+H&rft.aulast=Zhang&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathways of p-Nonylphenol (NP)-Induced Renal Toxicity Suggested by Global Gene Expression Profiles T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40855890; 4812990 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Camacho, L AU - Han, T AU - Fu, X. AU - Cooper, S AU - Fuscoe, J AU - Delclos, K Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Gene expression KW - P-Nonylphenol KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Pathways+of+p-Nonylphenol+%28NP%29-Induced+Renal+Toxicity+Suggested+by+Global+Gene+Expression+Profiles&rft.au=Camacho%2C+L%3BHan%2C+T%3BFu%2C+X.%3BCooper%2C+S%3BFuscoe%2C+J%3BDelclos%2C+K&rft.aulast=Camacho&rft.aufirst=L&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ICCVAM Recommendations on the use of Five In Vitro Pyrogen Test Methods for Assessing the Potential Pyrogenicity of Pharmaceuticals and Other Products T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40846803; 4811921 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - McFarland, R AU - Wind, M AU - Kulpa-Eddy, J AU - Tice, R AU - Stokes, W Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Pyrogens KW - Pharmaceuticals KW - Pyrogenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40846803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=ICCVAM+Recommendations+on+the+use+of+Five+In+Vitro+Pyrogen+Test+Methods+for+Assessing+the+Potential+Pyrogenicity+of+Pharmaceuticals+and+Other+Products&rft.au=McFarland%2C+R%3BWind%2C+M%3BKulpa-Eddy%2C+J%3BTice%2C+R%3BStokes%2C+W&rft.aulast=McFarland&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Ferrous Sulfate in Hexavalent Chromium-induced Cytotoxicity and Apoptosis in Human Dermal Fibroblasts T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40846536; 4811835 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Sellamuthu, R AU - Joseph, P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cytotoxicity KW - Sulfate KW - Fibroblasts KW - Apoptosis KW - Skin KW - Ferrous sulfate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40846536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Role+of+Ferrous+Sulfate+in+Hexavalent+Chromium-induced+Cytotoxicity+and+Apoptosis+in+Human+Dermal+Fibroblasts&rft.au=Sellamuthu%2C+R%3BJoseph%2C+P&rft.aulast=Sellamuthu&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Function and Signal Transduction of Nrf2 from a Metal's Perspective. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40845873; 4813382 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Ma, Q. AU - He, X. Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Signal transduction KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Function+and+Signal+Transduction+of+Nrf2+from+a+Metal%27s+Perspective.&rft.au=Ma%2C+Q.%3BHe%2C+X.&rft.aulast=Ma&rft.aufirst=Q.&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biodistribution of @@u3@H-Pigment Yellow 74, a Tattoo Ink Pigment, Following Intradermal Administration in Mice to Mimic Tattooing T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844733; 4811878 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Couch, L H AU - Gopee, N V AU - Howard, P C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Tattoos KW - Pigments KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Biodistribution+of+%40%40u3%40H-Pigment+Yellow+74%2C+a+Tattoo+Ink+Pigment%2C+Following+Intradermal+Administration+in+Mice+to+Mimic+Tattooing&rft.au=Couch%2C+L+H%3BGopee%2C+N+V%3BHoward%2C+P+C&rft.aulast=Couch&rft.aufirst=L&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicity and Tissue Distribution of Titanium Dioxide (TiO2) Nanoparticles in Subcutaneously and Intravenously Injected Mice over 6 Months T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844617; 4811859 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Umbreit, T AU - Goering, P L AU - Miller, T J AU - Weaver, J L AU - Francke-Carroll, S AU - Sadrieh, N AU - Kauffman, J AU - Guthrie, J AU - Robertson, J AU - Stratmeyer, M E Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Titanium dioxide KW - Mice KW - Nanoparticles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Toxicity+and+Tissue+Distribution+of+Titanium+Dioxide+%28TiO2%29+Nanoparticles+in+Subcutaneously+and+Intravenously+Injected+Mice+over+6+Months&rft.au=Umbreit%2C+T%3BGoering%2C+P+L%3BMiller%2C+T+J%3BWeaver%2C+J+L%3BFrancke-Carroll%2C+S%3BSadrieh%2C+N%3BKauffman%2C+J%3BGuthrie%2C+J%3BRobertson%2C+J%3BStratmeyer%2C+M+E&rft.aulast=Umbreit&rft.aufirst=T&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabonomic Analysis of Urine in Cisplatin-Induced Renal Toxicity in Rats and Mice T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844244; 4811636 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Beger, R D AU - Schnackenberg, L AU - Espandiari, P AU - Holland, R AU - Schmitt, T AU - Zhang, J AU - Nagothu, K AU - Portilla, D AU - Hanig, J AU - Sadrieh, N Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Mice KW - Urine KW - Rats KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Metabonomic+Analysis+of+Urine+in+Cisplatin-Induced+Renal+Toxicity+in+Rats+and+Mice&rft.au=Beger%2C+R+D%3BSchnackenberg%2C+L%3BEspandiari%2C+P%3BHolland%2C+R%3BSchmitt%2C+T%3BZhang%2C+J%3BNagothu%2C+K%3BPortilla%2C+D%3BHanig%2C+J%3BSadrieh%2C+N&rft.aulast=Beger&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acrylamide and Glycidamide-Induced Mitochondrial Gene Expression Profiles in Big Blue Transgenic Mice. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40842802; 4812665 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Manjanatha, M G AU - Moland, C L AU - Branham, W S AU - Shelton, S D AU - Tareke, E AU - Lee, T AU - Aidoo, A AU - Fuscoe, J C AU - Desai, V G Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mice KW - Gene expression KW - Acrylamide KW - Mitochondria KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40842802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Acrylamide+and+Glycidamide-Induced+Mitochondrial+Gene+Expression+Profiles+in+Big+Blue+Transgenic+Mice.&rft.au=Manjanatha%2C+M+G%3BMoland%2C+C+L%3BBranham%2C+W+S%3BShelton%2C+S+D%3BTareke%2C+E%3BLee%2C+T%3BAidoo%2C+A%3BFuscoe%2C+J+C%3BDesai%2C+V+G&rft.aulast=Manjanatha&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Gene Expression Profiles in Liver of Rats Treated with Riddelliine and Comfrey. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40842506; 4812573 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Mei, N AU - Guo, L AU - Dial, S L AU - Fuscoe, J C AU - Chen, T Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Liver KW - Rats KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40842506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Comparison+of+Gene+Expression+Profiles+in+Liver+of+Rats+Treated+with+Riddelliine+and+Comfrey.&rft.au=Mei%2C+N%3BGuo%2C+L%3BDial%2C+S+L%3BFuscoe%2C+J+C%3BChen%2C+T&rft.aulast=Mei&rft.aufirst=N&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Chronic Aloe Vera Administration on Colonic Protein Expression and Global DNA Methylation in the Fisher-344 Rat. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40842310; 4812618 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Pogribna, M AU - Beland, F A AU - Tryndyak, V AU - Boudreau, M D Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - DNA methylation KW - Aloe vera KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40842310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Effects+of+Chronic+Aloe+Vera+Administration+on+Colonic+Protein+Expression+and+Global+DNA+Methylation+in+the+Fisher-344+Rat.&rft.au=Pogribna%2C+M%3BBeland%2C+F+A%3BTryndyak%2C+V%3BBoudreau%2C+M+D&rft.aulast=Pogribna&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RAW264.7 Macrophage Cells - An In Vitro Alternative Food Safety Testing Platform Compatible with Various Food Types and Food-Borne Toxins. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40842180; 4811692 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Tolleson, W H AU - Jackson, L S Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxins KW - Food KW - Macrophages KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40842180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=RAW264.7+Macrophage+Cells+-+An+In+Vitro+Alternative+Food+Safety+Testing+Platform+Compatible+with+Various+Food+Types+and+Food-Borne+Toxins.&rft.au=Tolleson%2C+W+H%3BJackson%2C+L+S&rft.aulast=Tolleson&rft.aufirst=W&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Cerium Oxide on Rat Primary Alveolar Macrophages T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841380; 4812170 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Ma, J Y AU - Zhao, H AU - Barger, M AU - Castranova, V AU - Ma, J K Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cerium KW - Oxides KW - Alveoli KW - Macrophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Effects+of+Cerium+Oxide+on+Rat+Primary+Alveolar+Macrophages&rft.au=Ma%2C+J+Y%3BZhao%2C+H%3BBarger%2C+M%3BCastranova%2C+V%3BMa%2C+J+K&rft.aulast=Ma&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Design of an Inhalation Exposure System to Study Spot Welding Fume Characteristics and Biological Effects T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841370; 4812040 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Afshari, A A AU - Antonini, J M AU - Castranova, V AU - Boylstein, R AU - Kanwal, R AU - Frazer, D G Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Biological effects KW - Welding KW - Fumes KW - Inhalation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Design+of+an+Inhalation+Exposure+System+to+Study+Spot+Welding+Fume+Characteristics+and+Biological+Effects&rft.au=Afshari%2C+A+A%3BAntonini%2C+J+M%3BCastranova%2C+V%3BBoylstein%2C+R%3BKanwal%2C+R%3BFrazer%2C+D+G&rft.aulast=Afshari&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhalation of Stainless Steel Welding Fume Results in Dissimilar Inflammatory Responses in the Lungs of A/J and C57BL/6J Mice T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841069; 4812029 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Zeidler-Erdely, P C AU - Stone, S AU - Donlin, M AU - Moseley, A AU - Cumpston, J AU - Chen, B T AU - Frazer, D G AU - Young, S AU - Antonini, J M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung KW - Welding KW - Steel KW - Fumes KW - Inhalation KW - Mice KW - Stainless steel KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Inhalation+of+Stainless+Steel+Welding+Fume+Results+in+Dissimilar+Inflammatory+Responses+in+the+Lungs+of+A%2FJ+and+C57BL%2F6J+Mice&rft.au=Zeidler-Erdely%2C+P+C%3BStone%2C+S%3BDonlin%2C+M%3BMoseley%2C+A%3BCumpston%2C+J%3BChen%2C+B+T%3BFrazer%2C+D+G%3BYoung%2C+S%3BAntonini%2C+J+M&rft.aulast=Zeidler-Erdely&rft.aufirst=P&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Titanium Dioxide Nanoparticles Induce JB6 Cell Apoptosis through Activation of the Caspase-8/Bid Pathway T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40840926; 4812063 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Zhao, J AU - Bowman, L AU - Zhang, X AU - Ding, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Titanium dioxide KW - Apoptosis KW - Nanoparticles KW - Cell activation KW - BID protein KW - Caspase-8 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40840926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Titanium+Dioxide+Nanoparticles+Induce+JB6+Cell+Apoptosis+through+Activation+of+the+Caspase-8%2FBid+Pathway&rft.au=Zhao%2C+J%3BBowman%2C+L%3BZhang%2C+X%3BDing%2C+M&rft.aulast=Zhao&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of AP-1-MAPKs and NF-kB Signal Pathways by Tungsten Carbide-Cobalt Particles T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40840052; 4812180 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Ding, M AU - Zhao, J AU - Bowman, L AU - Leonard, S AU - Lu, Y. AU - Kisin, E AU - Murray, A AU - Vallyathan, V AU - Castranova, V AU - Shvedova, A Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Particulates KW - Tungsten KW - NF-B protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40840052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Induction+of+AP-1-MAPKs+and+NF-kB+Signal+Pathways+by+Tungsten+Carbide-Cobalt+Particles&rft.au=Ding%2C+M%3BZhao%2C+J%3BBowman%2C+L%3BLeonard%2C+S%3BLu%2C+Y.%3BKisin%2C+E%3BMurray%2C+A%3BVallyathan%2C+V%3BCastranova%2C+V%3BShvedova%2C+A&rft.aulast=Ding&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ICH S2B, a Standard Battery for Genotoxicity Testing of Pharmaceuticals: A Ten Year Perspective. How Well has it Served Us, can it be Improved? T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40839590; 4813437 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Jacobson-Kram, D Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Genotoxicity testing KW - Batteries KW - Pharmaceuticals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=ICH+S2B%2C+a+Standard+Battery+for+Genotoxicity+Testing+of+Pharmaceuticals%3A+A+Ten+Year+Perspective.+How+Well+has+it+Served+Us%2C+can+it+be+Improved%3F&rft.au=Jacobson-Kram%2C+D&rft.aulast=Jacobson-Kram&rft.aufirst=D&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of a Mouse Model to Evaluate Pulmonary Inflammation Caused by Floor Dust from a Water-Damaged Building T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40839048; 4812031 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Young, S AU - Cox-Ganser, J M AU - Wolfarth, M AU - Antonini, J M AU - Castranova, V AU - Park, J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Dust KW - Animal models KW - Lung KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Use+of+a+Mouse+Model+to+Evaluate+Pulmonary+Inflammation+Caused+by+Floor+Dust+from+a+Water-Damaged+Building&rft.au=Young%2C+S%3BCox-Ganser%2C+J+M%3BWolfarth%2C+M%3BAntonini%2C+J+M%3BCastranova%2C+V%3BPark%2C+J&rft.aulast=Young&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Genomic Hypomethylation during Hepatocarcinogenesis Induced by Peroxisome Proliferators in Rats. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40837821; 4812232 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Tryndyak, V AU - Boureiko, A AU - Melnyk, S AU - Rusyn, I AU - Pogribny, I Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Rats KW - Genomics KW - Peroxisomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40837821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Mechanism+of+Genomic+Hypomethylation+during+Hepatocarcinogenesis+Induced+by+Peroxisome+Proliferators+in+Rats.&rft.au=Tryndyak%2C+V%3BBoureiko%2C+A%3BMelnyk%2C+S%3BRusyn%2C+I%3BPogribny%2C+I&rft.aulast=Tryndyak&rft.aufirst=V&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA Regulatory Perspective on Reproductive and Developmental Testing for Biopharmaceuticals. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40837339; 4813494 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Ghantous, H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40837339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=FDA+Regulatory+Perspective+on+Reproductive+and+Developmental+Testing+for+Biopharmaceuticals.&rft.au=Ghantous%2C+H&rft.aulast=Ghantous&rft.aufirst=H&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA Perspective on Topical Nanomaterials in Cosmetics. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40837192; 4813459 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Bronaugh, R Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cosmetics KW - Nanotechnology KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40837192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=FDA+Perspective+on+Topical+Nanomaterials+in+Cosmetics.&rft.au=Bronaugh%2C+R&rft.aulast=Bronaugh&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Risk Factors in Progressive Massive Fibrosis in Coal Miners. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836811; 4812679 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Yucesoy, B AU - Johnson, V J AU - Fluharty, K AU - Kashon, M L AU - Slaven, J AU - Kissling, G AU - Germolec, D AU - Vallyathan, V AU - Luster, M I Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Coal KW - Occupational safety KW - Mining KW - Fibrosis KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Genetic+Risk+Factors+in+Progressive+Massive+Fibrosis+in+Coal+Miners.&rft.au=Yucesoy%2C+B%3BJohnson%2C+V+J%3BFluharty%2C+K%3BKashon%2C+M+L%3BSlaven%2C+J%3BKissling%2C+G%3BGermolec%2C+D%3BVallyathan%2C+V%3BLuster%2C+M+I&rft.aulast=Yucesoy&rft.aufirst=B&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - History and Overview of the Threshold of Toxicological Concern (TTC) Concept. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836133; 4813481 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - McDougal, A Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Historical account KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=History+and+Overview+of+the+Threshold+of+Toxicological+Concern+%28TTC%29+Concept.&rft.au=McDougal%2C+A&rft.aulast=McDougal&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbon Nanotube Acute Lung Exposure Induces Plasminogen Activator Inhibitor 1 T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836131; 4812005 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Erdely, A AU - Hulderman, T AU - Salmen, R AU - Liston, A AU - Zeidler-Erdely, P C AU - Simeonova, P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung KW - Nanotechnology KW - Plasminogen activator inhibitors KW - Carbon KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Carbon+Nanotube+Acute+Lung+Exposure+Induces+Plasminogen+Activator+Inhibitor+1&rft.au=Erdely%2C+A%3BHulderman%2C+T%3BSalmen%2C+R%3BListon%2C+A%3BZeidler-Erdely%2C+P+C%3BSimeonova%2C+P&rft.aulast=Erdely&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of In Vitro, Pharyngeal Aspiration, and Inhalation Results for Single-walled Carbon Nanotubes. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835981; 4813513 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Castranova, V Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Inhalation KW - Nanotechnology KW - Pharynx KW - Carbon KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Comparison+of+In+Vitro%2C+Pharyngeal+Aspiration%2C+and+Inhalation+Results+for+Single-walled+Carbon+Nanotubes.&rft.au=Castranova%2C+V&rft.aulast=Castranova&rft.aufirst=V&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Genetic Toxicity Test Battery in Hazard Identification for Potential Carcinogenicity of Veterinary Drugs and Feed Ingredients. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835666; 4812466 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Jagannath, D AU - Zhou, T Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Veterinary medicine KW - Toxicity testing KW - Feeds KW - Carcinogenicity KW - Drugs KW - Hazards KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Use+of+Genetic+Toxicity+Test+Battery+in+Hazard+Identification+for+Potential+Carcinogenicity+of+Veterinary+Drugs+and+Feed+Ingredients.&rft.au=Jagannath%2C+D%3BZhou%2C+T&rft.aulast=Jagannath&rft.aufirst=D&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Does Sandblasted Metal Attenuate or Enhance the Toxicity of Freshly Fractured Silica? T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835331; 4812141 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Pacurari, M AU - Robinson, V AU - Castranova, V AU - Leonard, S S AU - Chen, F AU - Vallyathan, V AU - Barger, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Silica KW - Metals KW - Fractures KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Does+Sandblasted+Metal+Attenuate+or+Enhance+the+Toxicity+of+Freshly+Fractured+Silica%3F&rft.au=Pacurari%2C+M%3BRobinson%2C+V%3BCastranova%2C+V%3BLeonard%2C+S+S%3BChen%2C+F%3BVallyathan%2C+V%3BBarger%2C+M&rft.aulast=Pacurari&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Sex- and Age-Related Differences in Heart of Rat Strain Fisher 344 Using Oligonucleotide Microarrays T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835266; 4812121 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Han, T AU - Branham, W S AU - Moland, C L AU - Holland, R AU - Schnackenberg, L K AU - Beger, R D AU - Jones, R AU - Edmondson, R AU - Taylor, J AU - Tong, W AU - Dragan, Y P AU - Fuscoe, J C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Oligonucleotides KW - Heart KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Analysis+of+Sex-+and+Age-Related+Differences+in+Heart+of+Rat+Strain+Fisher+344+Using+Oligonucleotide+Microarrays&rft.au=Han%2C+T%3BBranham%2C+W+S%3BMoland%2C+C+L%3BHolland%2C+R%3BSchnackenberg%2C+L+K%3BBeger%2C+R+D%3BJones%2C+R%3BEdmondson%2C+R%3BTaylor%2C+J%3BTong%2C+W%3BDragan%2C+Y+P%3BFuscoe%2C+J+C&rft.aulast=Han&rft.aufirst=T&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicity of Silicon Nanoparticles and Microparticles T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40834487; 4812197 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Choi, J AU - Zhang, Q AU - Hitchins, V M AU - Stratmeyer, M E AU - Goering, P L AU - Vytas, R AU - Wang, N Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Silicon KW - Nanoparticles KW - Microparticles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40834487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Toxicity+of+Silicon+Nanoparticles+and+Microparticles&rft.au=Choi%2C+J%3BZhang%2C+Q%3BHitchins%2C+V+M%3BStratmeyer%2C+M+E%3BGoering%2C+P+L%3BVytas%2C+R%3BWang%2C+N&rft.aulast=Choi&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary Toxicity Associated with Non-Dispersed Titanium Dioxide Nanorods. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40834412; 4812158 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Roberts, J R AU - Schwegler-Berry, D AU - Leonard, S S AU - Karim, A AU - Tirumala, V AU - Antonini, J M AU - Castranova, V Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Titanium dioxide KW - Lung KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40834412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Pulmonary+Toxicity+Associated+with+Non-Dispersed+Titanium+Dioxide+Nanorods.&rft.au=Roberts%2C+J+R%3BSchwegler-Berry%2C+D%3BLeonard%2C+S+S%3BKarim%2C+A%3BTirumala%2C+V%3BAntonini%2C+J+M%3BCastranova%2C+V&rft.aulast=Roberts&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurotoxicity Assessment of Silver-25 Nanoparticles: An In Vitro and In Vivo Study T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40834402; 4812191 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Rahman, M F AU - Wang, J AU - Patterson, T A AU - Duhart, H M AU - Newport, G D AU - Hussain, S M AU - Schlager, J J AU - Ali, S F Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Neurotoxicity KW - Nanoparticles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40834402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Neurotoxicity+Assessment+of+Silver-25+Nanoparticles%3A+An+In+Vitro+and+In+Vivo+Study&rft.au=Rahman%2C+M+F%3BWang%2C+J%3BPatterson%2C+T+A%3BDuhart%2C+H+M%3BNewport%2C+G+D%3BHussain%2C+S+M%3BSchlager%2C+J+J%3BAli%2C+S+F&rft.aulast=Rahman&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Gaba Agonists on Ketamine-Induced Neurotoxicity in PND-3 Monkey Frontal Cortical Cultures T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40833332; 4811270 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Wang, C AU - Sadovova AU - Patterson, T A AU - Zou, X AU - Zhang, X AU - Hanig, J P AU - Paule, M G AU - Slikker, W Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Neurotoxicity KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40833332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Effect+of+Gaba+Agonists+on+Ketamine-Induced+Neurotoxicity+in+PND-3+Monkey+Frontal+Cortical+Cultures&rft.au=Wang%2C+C%3BSadovova%3BPatterson%2C+T+A%3BZou%2C+X%3BZhang%2C+X%3BHanig%2C+J+P%3BPaule%2C+M+G%3BSlikker%2C+W&rft.aulast=Wang&rft.aufirst=C&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Understanding Toxicity through the Analyses of a Well Designed ToxML Databases T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40832784; 4811463 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Storaska, A AU - Arvidson, K AU - Benz, R AU - Brown, R AU - Bower, D AU - Lee, E AU - Marchant, C AU - Sun, G AU - Wood, J AU - Yang, C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Understanding+Toxicity+through+the+Analyses+of+a+Well+Designed+ToxML+Databases&rft.au=Storaska%2C+A%3BArvidson%2C+K%3BBenz%2C+R%3BBrown%2C+R%3BBower%2C+D%3BLee%2C+E%3BMarchant%2C+C%3BSun%2C+G%3BWood%2C+J%3BYang%2C+C&rft.aulast=Storaska&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Corticosterone Pretreatment Attenuates Neurodegeneration and Blood-Brain Barrier Disruption Following Excitotoxic Damage from Kainic Acid T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40832465; 4811353 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Benkovic, S A AU - O'Callaghan, J P AU - Miller, D B Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Excitotoxicity KW - Corticosterone KW - Neurodegeneration KW - Kainic acid KW - Blood-brain barrier KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Corticosterone+Pretreatment+Attenuates+Neurodegeneration+and+Blood-Brain+Barrier+Disruption+Following+Excitotoxic+Damage+from+Kainic+Acid&rft.au=Benkovic%2C+S+A%3BO%27Callaghan%2C+J+P%3BMiller%2C+D+B&rft.aulast=Benkovic&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adverse Effects of Pharmaceuticals: A. Construction of a Relational Database of Adverse Cardiological Effects Using FDA Archives, Pharmapendium, and Public Sources T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40832320; 4811465 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Frid, A A AU - Matthews, E J AU - Kruhlak, N L AU - Benz, R AU - Contrera, J F Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Side effects KW - FDA KW - Databases KW - Pharmaceuticals KW - Archives KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Adverse+Effects+of+Pharmaceuticals%3A+A.+Construction+of+a+Relational+Database+of+Adverse+Cardiological+Effects+Using+FDA+Archives%2C+Pharmapendium%2C+and+Public+Sources&rft.au=Frid%2C+A+A%3BMatthews%2C+E+J%3BKruhlak%2C+N+L%3BBenz%2C+R%3BContrera%2C+J+F&rft.aulast=Frid&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adverse Effects of Pharmaceuticals: B. Prediction of Adverse Cardiological Effects Using MC4PC, Leadscope, Bioepisteme, and MDL-QSAR Software Programs T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40831753; 4811472 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Matthews, E J AU - Frid, A A AU - Kruhlak, N L AU - Benz, R AU - Contrera, J F Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Side effects KW - Computer programs KW - Lead KW - Software KW - Pharmaceuticals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40831753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Adverse+Effects+of+Pharmaceuticals%3A+B.+Prediction+of+Adverse+Cardiological+Effects+Using+MC4PC%2C+Leadscope%2C+Bioepisteme%2C+and+MDL-QSAR+Software+Programs&rft.au=Matthews%2C+E+J%3BFrid%2C+A+A%3BKruhlak%2C+N+L%3BBenz%2C+R%3BContrera%2C+J+F&rft.aulast=Matthews&rft.aufirst=E&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Screening the Activation State of Multiple Phosphoproteins Reveals the In Vivo Impact of Stressors on Brain Signaling Pathways Controlling Cellular Structure T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40831401; 4811358 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Miller, D B AU - O'Callaghan, J P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Brain KW - Signal transduction KW - Phosphoproteins KW - Screening KW - Ecosystem disturbance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40831401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Screening+the+Activation+State+of+Multiple+Phosphoproteins+Reveals+the+In+Vivo+Impact+of+Stressors+on+Brain+Signaling+Pathways+Controlling+Cellular+Structure&rft.au=Miller%2C+D+B%3BO%27Callaghan%2C+J+P&rft.aulast=Miller&rft.aufirst=D&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Dermal Penetration of Titanium Dioxide (TiO2) from Sunscreen Formulations Containing Micron- and Nano-scale Particles of TiO2. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40830589; 4812172 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Sadrieh, N AU - Wokovich, A M AU - Gopee, N V AU - Siitonen, P H AU - Cozart, C R AU - Howard, P C AU - Doub, W H AU - Buhse, L F Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Particulates KW - Titanium dioxide KW - Sunscreens KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40830589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Analysis+of+Dermal+Penetration+of+Titanium+Dioxide+%28TiO2%29+from+Sunscreen+Formulations+Containing+Micron-+and+Nano-scale+Particles+of+TiO2.&rft.au=Sadrieh%2C+N%3BWokovich%2C+A+M%3BGopee%2C+N+V%3BSiitonen%2C+P+H%3BCozart%2C+C+R%3BHoward%2C+P+C%3BDoub%2C+W+H%3BBuhse%2C+L+F&rft.aulast=Sadrieh&rft.aufirst=N&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhalation of Carbon Nanotubes Induces Oxidative Stress and Cytokine Response Causing Respiratory Impairment and Pulmonary Fibrosis in Mice T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40830521; 4812154 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Shvedova, A A AU - Kisin, E AU - Murray, A R AU - Johnson, V AU - Gorelik, O AU - Arepalli, S AU - Hubbs, A F AU - Mercer, R R AU - Stone, S AU - Frazer, D AU - Chen, T AU - Deye, G AU - Maynard, A AU - Baron, P AU - Mason, R AU - Kadiiska, M AU - Stadler, K AU - Mouithys-Mickalad, A AU - Castranova, V AU - Kagan, V E Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Inhalation KW - Mice KW - Nanotechnology KW - Oxidative stress KW - Fibrosis KW - Lung diseases KW - Cytokines KW - Carbon KW - Nanotubes KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40830521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Inhalation+of+Carbon+Nanotubes+Induces+Oxidative+Stress+and+Cytokine+Response+Causing+Respiratory+Impairment+and+Pulmonary+Fibrosis+in+Mice&rft.au=Shvedova%2C+A+A%3BKisin%2C+E%3BMurray%2C+A+R%3BJohnson%2C+V%3BGorelik%2C+O%3BArepalli%2C+S%3BHubbs%2C+A+F%3BMercer%2C+R+R%3BStone%2C+S%3BFrazer%2C+D%3BChen%2C+T%3BDeye%2C+G%3BMaynard%2C+A%3BBaron%2C+P%3BMason%2C+R%3BKadiiska%2C+M%3BStadler%2C+K%3BMouithys-Mickalad%2C+A%3BCastranova%2C+V%3BKagan%2C+V+E&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Protective Effect of L-carnitine on Phencyclidine-induced Cortical Apoptosis in the Developing Rat T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40829814; 4811240 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Zou, X AU - Boctor, S Y AU - Sadovova, N AU - Ferguson , S. AU - Paule, M G AU - Slikker, W AU - Wang, C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Apoptosis KW - Cortex KW - L-Carnitine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40829814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Protective+Effect+of+L-carnitine+on+Phencyclidine-induced+Cortical+Apoptosis+in+the+Developing+Rat&rft.au=Zou%2C+X%3BBoctor%2C+S+Y%3BSadovova%2C+N%3BFerguson+%2C+S.%3BPaule%2C+M+G%3BSlikker%2C+W%3BWang%2C+C&rft.aulast=Zou&rft.aufirst=X&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of Biomarker Genes for the Exposure of Aristolochic Acid in Rat Kidney T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40828542; 4812861 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Chen, T AU - Mei, N AU - Guo, L Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Bioindicators KW - Kidneys KW - Biomarkers KW - Aristolochic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40828542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Determination+of+Biomarker+Genes+for+the+Exposure+of+Aristolochic+Acid+in+Rat+Kidney&rft.au=Chen%2C+T%3BMei%2C+N%3BGuo%2C+L&rft.aulast=Chen&rft.aufirst=T&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of NMDA Receptor Subunits in Phencyclidine (PCP)-Induced Neuronal Apoptosis in Rats T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40825840; 4811272 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Paule, M G AU - Sadovova, N AU - Zou, X AU - Zhang, X AU - Slikker, W AU - Wang, C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Rats KW - Apoptosis KW - N-Methyl-D-aspartic acid receptors KW - Phencyclidine KW - Glutamic acid receptors (ionotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40825840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Role+of+NMDA+Receptor+Subunits+in+Phencyclidine+%28PCP%29-Induced+Neuronal+Apoptosis+in+Rats&rft.au=Paule%2C+M+G%3BSadovova%2C+N%3BZou%2C+X%3BZhang%2C+X%3BSlikker%2C+W%3BWang%2C+C&rft.aulast=Paule&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disruption of Antioxidant Defense and DNA Repair Systems during 2-acetylaminofluorene-induced Hepatocarcinogenesis in Rats T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40825707; 4811541 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Bagnyukova, T V AU - Powell, C L AU - Montgomery, B AU - Beland, F A AU - Pogribny, I P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Rats KW - Antioxidants KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40825707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Disruption+of+Antioxidant+Defense+and+DNA+Repair+Systems+during+2-acetylaminofluorene-induced+Hepatocarcinogenesis+in+Rats&rft.au=Bagnyukova%2C+T+V%3BPowell%2C+C+L%3BMontgomery%2C+B%3BBeland%2C+F+A%3BPogribny%2C+I+P&rft.aulast=Bagnyukova&rft.aufirst=T&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Anthrax lethal toxin increases superoxide production in murine neutrophils via differential effects on MAPK signaling pathways. AN - 70368379; 18322225 AB - The combination of lethal factor and its receptor-binding partner, protective Ag, is termed lethal toxin (LT) and has critical pathogenic activity during infection with Bacillus anthracis. We herein report that anthrax LT binds and enters murine neutrophils, leading to the cleavage of mitogen-activated protein kinase kinase/MEK/MAPKK 1-4 and 6, but not mitogen-activated protein kinase kinase 5 and 7. Anthrax LT treatment of neutrophils disrupts signaling to downstream MAPK targets in response to TLR stimulation. Following anthrax LT treatment, ERK family and p38 phosphorylation are nearly completely blocked, but signaling to JNK family members persists in vitro and ex vivo. In contrast to previous reports involving human neutrophils, anthrax LT treatment of murine neutrophils increases their production of superoxide in response to PMA or TLR stimulation in vitro or ex vivo. Although this enhanced superoxide production correlates with effects due to the LT-induced blockade of ERK signaling, it requires JNK signaling that remains largely intact despite the activity of anthrax LT. These findings reveal a previously unrecognized mechanism through which anthrax LT supports a critical proinflammatory response of murine neutrophils. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Xu, Lixin AU - Fang, Hui AU - Frucht, David M AD - Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - 4139 EP - 4147 VL - 180 IS - 6 SN - 0022-1767, 0022-1767 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Inflammation Mediators KW - Protein Kinase Inhibitors KW - anthrax toxin KW - Superoxides KW - 11062-77-4 KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 1 KW - Mitogen-Activated Protein Kinase 3 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Drug Delivery Systems KW - Protein Kinase Inhibitors -- pharmacology KW - Mitogen-Activated Protein Kinase 3 -- physiology KW - JNK Mitogen-Activated Protein Kinases -- physiology KW - Mice KW - Mice, Inbred BALB C KW - Mitogen-Activated Protein Kinase 1 -- physiology KW - Inflammation Mediators -- toxicity KW - Cells, Cultured KW - JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors KW - Mice, Inbred C57BL KW - Mitogen-Activated Protein Kinase 1 -- antagonists & inhibitors KW - Neutrophils -- metabolism KW - Antigens, Bacterial -- toxicity KW - Superoxides -- metabolism KW - Neutrophils -- pathology KW - Neutrophils -- enzymology KW - MAP Kinase Signaling System -- immunology KW - Bacterial Toxins -- toxicity KW - Up-Regulation -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70368379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Anthrax+lethal+toxin+increases+superoxide+production+in+murine+neutrophils+via+differential+effects+on+MAPK+signaling+pathways.&rft.au=Xu%2C+Lixin%3BFang%2C+Hui%3BFrucht%2C+David+M&rft.aulast=Xu&rft.aufirst=Lixin&rft.date=2008-03-15&rft.volume=180&rft.issue=6&rft.spage=4139&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Smallpox Vaccine Injury Compensation Program. AN - 70313329; 18284357 AB - In January 2003, the Secretary of the US Department of Health and Human Services (DHHS) announced that certain individuals should receive smallpox vaccine or other countermeasures to be prepared to serve the civilian population in the event of a smallpox bioterrorism event. In April 2003, Congress passed and the President signed the Smallpox Emergency Personnel Protection Act of 2003. This act created the Smallpox Vaccine Injury Compensation Program to provide medical and lost employment income coverage as a payer of last resort to persons who sustain a covered medical injury as a direct result of receiving smallpox vaccination voluntarily under a DHHS-approved smallpox emergency response plan. As of September 2006, 62 persons had requested benefits, of whom 19 had been determined to be medically eligible, 27 were denied benefits, and 16 submitted the request after the legislatively defined filing deadline. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Clark, Paul T AU - Levin, Stan AD - US Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, and Smallpox Vaccine Injury Compensation Program, Rockville, Maryland, USA. Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - S179 EP - S181 VL - 46 Suppl 3 KW - DryVax vaccine KW - 0 KW - Smallpox Vaccine KW - Index Medicus KW - United States KW - Eligibility Determination KW - Adverse Drug Reaction Reporting Systems -- economics KW - Humans KW - Disability Evaluation KW - Income KW - Insurance, Liability -- economics KW - Mass Vaccination -- adverse effects KW - Bioterrorism -- prevention & control KW - Smallpox Vaccine -- adverse effects KW - Mass Vaccination -- economics KW - Insurance, Liability -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70313329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=The+Smallpox+Vaccine+Injury+Compensation+Program.&rft.au=Clark%2C+Paul+T%3BLevin%2C+Stan&rft.aulast=Clark&rft.aufirst=Paul&rft.date=2008-03-15&rft.volume=46+Suppl+3&rft.issue=&rft.spage=S179&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/10.1086%2F524381 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-04 N1 - Date created - 2008-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/524381 ER - TY - CPAPER T1 - An Antibody-Based Multiplex Bead Assay to Determine the Potency and Composition of Allergen Extracts T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40730983; 4763719 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - deVore, N AU - Slater, J E Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Allergens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40730983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=An+Antibody-Based+Multiplex+Bead+Assay+to+Determine+the+Potency+and+Composition+of+Allergen+Extracts&rft.au=deVore%2C+N%3BSlater%2C+J+E&rft.aulast=deVore&rft.aufirst=N&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identifying Fungal Isolates using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40722797; 4763476 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Green, B J AU - Hettick, J M AU - Schmechel, D AU - Kashon, M L AU - Slaven, J E AU - Blachere, F M AU - Buskirk, A AU - Janotka, E AU - Siegel, P D AU - Beezhold, D H Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Mass spectroscopy KW - Lasers KW - Desorption KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40722797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Identifying+Fungal+Isolates+using+Matrix-Assisted+Laser+Desorption%2FIonization+Time-of-Flight+Mass+Spectrometry&rft.au=Green%2C+B+J%3BHettick%2C+J+M%3BSchmechel%2C+D%3BKashon%2C+M+L%3BSlaven%2C+J+E%3BBlachere%2C+F+M%3BBuskirk%2C+A%3BJanotka%2C+E%3BSiegel%2C+P+D%3BBeezhold%2C+D+H&rft.aulast=Green&rft.aufirst=B&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elevated Serum IgE Concentrations in Systemic Lupus Erythematosus are Related to History of Childhood Allergy, Asthma, and Hives T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40717820; 4764215 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Biagini, R E AU - Smith, J P AU - Sammons, D L AU - Mackenzie, B A AU - Parks, C G Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Respiratory diseases KW - Asthma KW - Historical account KW - Children KW - Systemic lupus erythematosus KW - Hypersensitivity KW - Immunoglobulin E KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40717820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Elevated+Serum+IgE+Concentrations+in+Systemic+Lupus+Erythematosus+are+Related+to+History+of+Childhood+Allergy%2C+Asthma%2C+and+Hives&rft.au=Biagini%2C+R+E%3BSmith%2C+J+P%3BSammons%2C+D+L%3BMackenzie%2C+B+A%3BParks%2C+C+G&rft.aulast=Biagini&rft.aufirst=R&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Multiclass determination and confirmation of antibiotic residues in honey using LC-MS/MS. AN - 70362454; 18257525 AB - A multiclass method has been developed for the determination and confirmation in honey of tetracyclines (chlortetracycline, doxycycline, oxytetracycline, and tetracycline), fluoroquinolones (ciprofloxacin, danofloxacin, difloxacin, enrofloxacin, and sarafloxacin), macrolides (tylosin), lincosamides (lincomycin), aminoglycosides (streptomycin), sulfonamides (sulfathiazole), phenicols (chloramphenicol), and fumagillin residues using liquid chromatography tandem mass spectrometry (LC-MS/MS). Erythromycin (a macrolide) and monensin (an ionophore) can be detected and confirmed but not quantitated. Honey samples (approximately 2 g) are dissolved in 10 mL of water and centrifuged. An aliquot of the supernatant is used to determine streptomycin. The remaining supernatant is filtered through a fine-mesh nylon fabric and cleaned up by solid phase extraction. After solvent evaporation and sample reconstitution, 15 antibiotics are assayed by LC-MS/MS using electrospray ionization (ESI) in positive ion mode. Afterward, chloramphenicol is assayed using ESI in negative ion mode. The method has been validated at the low part per billion levels for most of the drugs with accuracies between 65 and 104% and coefficients of variation less than 17%. The evaluation of matrix effects caused by honey of different floral origin is presented. JF - Journal of agricultural and food chemistry AU - Lopez, Mayda I AU - Pettis, Jeffery S AU - Smith, I Barton AU - Chu, Pak-Sin AD - Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA. mayda.lopez@fda.hhs.gov Y1 - 2008/03/12/ PY - 2008 DA - 2008 Mar 12 SP - 1553 EP - 1559 VL - 56 IS - 5 SN - 0021-8561, 0021-8561 KW - Anti-Bacterial Agents KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Humans KW - Honey -- analysis KW - Chromatography, Liquid -- methods KW - Drug Residues -- analysis KW - Anti-Bacterial Agents -- analysis KW - Food Contamination -- analysis KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70362454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Multiclass+determination+and+confirmation+of+antibiotic+residues+in+honey+using+LC-MS%2FMS.&rft.au=Lopez%2C+Mayda+I%3BPettis%2C+Jeffery+S%3BSmith%2C+I+Barton%3BChu%2C+Pak-Sin&rft.aulast=Lopez&rft.aufirst=Mayda&rft.date=2008-03-12&rft.volume=56&rft.issue=5&rft.spage=1553&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=00218561&rft_id=info:doi/10.1021%2Fjf073236w LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-28 N1 - Date created - 2008-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf073236w ER - TY - CPAPER T1 - Genotype Distribution in Acute and Chronic Hepatitis B in the Netherlands T2 - 2008 Winter and Annual Meeting of the European Society for Clinical Virology (ESCV 2008) AN - 40782993; 4792268 JF - 2008 Winter and Annual Meeting of the European Society for Clinical Virology (ESCV 2008) AU - Bruisten, Sylvia AU - van Houdt, Robin AU - Koedijk, Femke AU - Op de Coul, Eline AU - Coutinho, Roel AU - Boot, Hein Y1 - 2008/03/12/ PY - 2008 DA - 2008 Mar 12 KW - Netherlands KW - Hepatitis B KW - Genotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Winter+and+Annual+Meeting+of+the+European+Society+for+Clinical+Virology+%28ESCV+2008%29&rft.atitle=Genotype+Distribution+in+Acute+and+Chronic+Hepatitis+B+in+the+Netherlands&rft.au=Bruisten%2C+Sylvia%3Bvan+Houdt%2C+Robin%3BKoedijk%2C+Femke%3BOp+de+Coul%2C+Eline%3BCoutinho%2C+Roel%3BBoot%2C+Hein&rft.aulast=Bruisten&rft.aufirst=Sylvia&rft.date=2008-03-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Winter+and+Annual+Meeting+of+the+European+Society+for+Clinical+Virology+%28ESCV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.escv2008.fi/abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Medicine. Moving toward transparency of clinical trials. AN - 70370251; 18323436 JF - Science (New York, N.Y.) AU - Zarin, Deborah A AU - Tse, Tony AD - National Library of Medicine, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20894, USA. dzarin@mail.nih.gov Y1 - 2008/03/07/ PY - 2008 DA - 2008 Mar 07 SP - 1340 EP - 1342 VL - 319 IS - 5868 KW - Index Medicus KW - United States KW - Intellectual Property KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Product Surveillance, Postmarketing KW - Databases, Factual KW - Publishing KW - Public Policy KW - Disclosure KW - Registries KW - Access to Information KW - Clinical Trials as Topic -- standards KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Clinical Trials as Topic -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70370251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Medicine.+Moving+toward+transparency+of+clinical+trials.&rft.au=Zarin%2C+Deborah+A%3BTse%2C+Tony&rft.aulast=Zarin&rft.aufirst=Deborah&rft.date=2008-03-07&rft.volume=319&rft.issue=5868&rft.spage=1340&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/10.1126%2Fscience.1153632 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-21 N1 - Date created - 2008-03-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2004 Sep 15;292(11):1359-62 [15355937] JAMA. 2004 Sep 15;292(11):1363-4 [15355936] Lancet. 1991 Apr 13;337(8746):867-72 [1672966] J R Soc Med. 1995;88 Suppl 24:12-6 [7776320] JAMA. 2004 Dec 1;292(21):2622-31 [15572720] Circulation. 2005 Sep 27;112(13):2040-2 [16172264] N Engl J Med. 2005 Dec 29;353(26):2779-87 [16382064] Science. 2006 Jan 13;311(5758):180-1 [16410509] BMJ. 2006 Mar 25;332(7543):677-8 [16554332] Lancet. 2006 May 20;367(9523):1631-3 [16714166] N Engl J Med. 2006 Nov 23;355(21):2169-71 [17124012] BMJ. 2007 Jan 20;334(7585):120-3 [17235089] N Engl J Med. 2007 Apr 19;356(16):1601-4 [17442902] JAMA. 2007 May 16;297(19):2112-20 [17507347] N Engl J Med. 2007 Jun 14;356(24):2457-71 [17517853] N Engl J Med. 2007 Jun 14;356(24):2522-4 [17517854] N Engl J Med. 2007 Jun 28;356(26):2734-6 [17548427] Nat Rev Drug Discov. 2007 Jul;6(7):532-9 [17491596] Arch Intern Med. 2007 Aug 13-27;167(15):1576-80 [17698679] N Engl J Med. 2007 Aug 30;357(9):844-6 [17687124] N Engl J Med. 2007 Oct 25;357(17):1756-7 [17914035] Nat Clin Pract Neurol. 2007 Nov;3(11):590-1 [17876349] N Engl J Med. 2007 Nov 29;357(22):2219-21 [18046025] N Engl J Med. 2008 Jan 17;358(3):252-60 [18199864] N Engl J Med. 2006 Nov 23;355(21):2171-3 [17124013] J Clin Oncol. 1986 Oct;4(10):1529-41 [3760920] JAMA. 2002 Jul 17;288(3):363-5 [12117402] Ann Intern Med. 2002 Aug 20;137(4):290 [12186521] Science. 2004 Feb 6;303(5659):745 [14764841] Comment In: Science. 2008 Oct 3;322(5898):44-6 [18832629] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1126/science.1153632 ER - TY - CPAPER T1 - FOXP3 Expression in HUM Cancer Cells T2 - 2008 Conference of the International Society for Cellular Oncology (ISCO 2008) AN - 40976315; 4874324 JF - 2008 Conference of the International Society for Cellular Oncology (ISCO 2008) AU - Karanikas, Viaos AU - Speletas, Matthaios AU - Zamanakou, Maria AU - Kalala, Fani AU - Loules, Gedeon AU - Kerenidi, Theodora AU - Barda, Aggeliki AU - Gourgoulianis, Konstantinos AU - Germenis, Anastasios Y1 - 2008/03/05/ PY - 2008 DA - 2008 Mar 05 KW - Cancer KW - Foxp3 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40976315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Conference+of+the+International+Society+for+Cellular+Oncology+%28ISCO+2008%29&rft.atitle=FOXP3+Expression+in+HUM+Cancer+Cells&rft.au=Karanikas%2C+Viaos%3BSpeletas%2C+Matthaios%3BZamanakou%2C+Maria%3BKalala%2C+Fani%3BLoules%2C+Gedeon%3BKerenidi%2C+Theodora%3BBarda%2C+Aggeliki%3BGourgoulianis%2C+Konstantinos%3BGermenis%2C+Anastasios&rft.aulast=Karanikas&rft.aufirst=Viaos&rft.date=2008-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Conference+of+the+International+Society+for+Cellular+Oncology+%28ISCO+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://iospress.metapress.com/content/p39v6085561v/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Characterization of high intensity focused ultrasound transducers using acoustic streaming. AN - 742777089; pmid-18345858 AB - A new approach for characterizing high intensity focused ultrasound (HIFU) transducers is presented. The technique is based upon the acoustic streaming field generated by absorption of the HIFU beam in a liquid medium. The streaming field is quantified using digital particle image velocimetry, and a numerical algorithm is employed to compute the acoustic intensity field giving rise to the observed streaming field. The method as presented here is applicable to moderate intensity regimes, above the intensities which may be damaging to conventional hydrophones, but below the levels where nonlinear propagation effects are appreciable. Intensity fields and acoustic powers predicted using the streaming method were found to agree within 10% with measurements obtained using hydrophones and radiation force balances. Besides acoustic intensity fields, the streaming technique may be used to determine other important HIFU parameters, such as beam tilt angle or absorption of the propagation medium. JF - The Journal of the Acoustical Society of America AU - Hariharan, Prasanna AU - Myers, Matthew R AU - Robinson, Ronald A AU - Maruvada, Subha H AU - Sliwa, Jack AU - Banerjee, Rupak K AD - Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1706 EP - 1719 VL - 123 IS - 3 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Absorption KW - Acoustics -- instrumentation KW - Transducers KW - Ultrasonics KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742777089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Characterization+of+high+intensity+focused+ultrasound+transducers+using+acoustic+streaming.&rft.au=Hariharan%2C+Prasanna%3BMyers%2C+Matthew+R%3BRobinson%2C+Ronald+A%3BMaruvada%2C+Subha+H%3BSliwa%2C+Jack%3BBanerjee%2C+Rupak+K&rft.aulast=Hariharan&rft.aufirst=Prasanna&rft.date=2008-03-01&rft.volume=123&rft.issue=3&rft.spage=1706&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Responder safety and health: preparing for future disasters. AN - 71621894; 18500715 AB - This article reviews lessons learned about managing the safety and health of workers who were involved in disaster response, recovery, and cleanup after the 2001 World Trade Center (WTC) disaster. The first two sections review ongoing responder health burdens and the tragic toll of this disaster from a worker safety and health perspective. The remaining sections address changes in federal infrastructure, response planning, and resources for protection of response and recovery personnel. Proper preparation includes pre-event and "just-in-time" disaster-worker training on likely hazards, organizational assets for hazard monitoring, and hands-on instruction in the use of assigned protective equipment. Good planning includes predeployment medical review to ensure "fitness for duty" and considers the following: (1) personal risk factors, (2) hazards likely to be associated with particular field locations, and (3) risks involved with assigned tasks (eg, workload and pace, work/rest cycles, available resources, and team/supervisory dynamics). Planning also should address worker health surveillance, medical monitoring, and availability of medical care (including mental health services). Disaster safety managers should anticipate likely hazards within planning scenarios and prepare asset inventories to facilitate making timely safety decisions. Disaster safety management begins immediately and provides ongoing real-time guidance to incident leadership at all levels of government. Robust standards must be met to reliably protect workers/responders. An integrated and measurable multiagency safety management function must be built into the incident command system before an incident occurs. This function delineates roles and responsibilities for rapid exposure assessments, ensuring cross-agency consistency in data interpretation, and timely, effective communication of information and control strategies. The ability to perform this safety management function should be tested and evaluated in exercise simulations and drills at multiple levels. Joint planning and exercising of the safety management plan and its function are effective ways to build interagency relationships and to be more systemic in managing logistics for safety equipment and converging personnel. Planning must include mechanisms to enable safety decisions to be implemented-such as effective and rapid scene control (site access), personnel tracking, and safety enforcement. Worker safety and health preparedness and leadership are essential for protecting workers and promoting resiliency among personnel involved in disaster response, recovery, and cleanup. Copyright (c) 2008 Mount Sinai School of Medicine JF - The Mount Sinai journal of medicine, New York AU - Reissman, Dori B AU - Howard, John AD - National Institute for Occupational Safety and Health, Washington, DC, USA. DReissman@cdc.gov PY - 2008 SP - 135 EP - 141 VL - 75 IS - 2 SN - 0027-2507, 0027-2507 KW - Index Medicus KW - Occupational Health KW - Volunteers KW - New York City -- epidemiology KW - Humans KW - Occupational Diseases -- prevention & control KW - Lung Diseases -- epidemiology KW - United States -- epidemiology KW - Lung Diseases -- prevention & control KW - Relief Work KW - Occupational Exposure -- adverse effects KW - Disaster Planning KW - Safety Management KW - September 11 Terrorist Attacks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71621894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.atitle=Responder+safety+and+health%3A+preparing+for+future+disasters.&rft.au=Reissman%2C+Dori+B%3BHoward%2C+John&rft.aulast=Reissman&rft.aufirst=Dori&rft.date=2008-03-01&rft.volume=75&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.issn=00272507&rft_id=info:doi/10.1002%2Fmsj.20024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-03 N1 - Date created - 2008-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/msj.20024 ER - TY - JOUR T1 - The 9/11 World Trade Center disaster: past and future. AN - 71616769; 18500707 JF - The Mount Sinai journal of medicine, New York AU - Howard, John AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, World Trade Center Health Programs, US Department of Health and Human Services, Washington, DC, USA. PY - 2008 SP - 65 EP - 66 VL - 75 IS - 2 SN - 0027-2507, 0027-2507 KW - Particulate Matter KW - 0 KW - Index Medicus KW - New York City KW - Humans KW - Occupational Exposure -- adverse effects KW - Inhalation Exposure -- adverse effects KW - Disaster Planning -- trends KW - Particulate Matter -- adverse effects KW - Environmental Exposure -- adverse effects KW - September 11 Terrorist Attacks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71616769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.atitle=The+9%2F11+World+Trade+Center+disaster%3A+past+and+future.&rft.au=Howard%2C+John&rft.aulast=Howard&rft.aufirst=John&rft.date=2008-03-01&rft.volume=75&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.issn=00272507&rft_id=info:doi/10.1002%2Fmsj.20037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-03 N1 - Date created - 2008-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/msj.20037 ER - TY - JOUR T1 - Detection of ricin in food using electrochemiluminescence-based technology. AN - 70738825; 18476351 AB - Ricin is a toxic ribosome inactivating protein (RIP-II) present in beans of the castor plant, Ricinus communis. Its potential as a biodefense threat has made the rapid, sensitive detection of ricin in food important to the U.S. Food and Drug Administration. Samples of juice, dairy products, soda, vegetables, bakery products, chocolate, and condiments were spiked with varying concentrations of ricin and analyzed using a 96-well format, electrochemiluminescence (ECL) immunoassay. Assay configurations included the use of a monoclonal capture antibody coupled with either a polyclonal or monoclonal detector antibody. The samples and detector antibodies were either added sequentially or in combination during the capture step. Using the polyclonal antibody, 0.04 ng/mL ricin was detected in analytical samples prepared from several beverages. By simultaneously incubating the sample with detector antibody, it was possible to decrease the assay time to a single 20 min incubation step with a limit of detection <10 ng/mL. Assays run according to this single incubation step exhibited a hook effect (decrease in signal at high concentrations of ricin), but because of the large signal-to-noise ratio associated with the ECL assay, the response remained above background and detectable. Thus, the ECL assay was uniquely suited for the screening of samples for ricin. JF - Journal of AOAC International AU - Garber, Eric A E AU - O'Brien, Thomas W AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Division of Bioanalytical Chemistry, Office of Regulatory Science, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. Eric.Garber@fda.hhs.gov PY - 2008 SP - 376 EP - 382 VL - 91 IS - 2 SN - 1060-3271, 1060-3271 KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - Enzyme-Linked Immunosorbent Assay KW - Luminescent Measurements -- methods KW - Food Analysis -- methods KW - Ricin -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70738825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Detection+of+ricin+in+food+using+electrochemiluminescence-based+technology.&rft.au=Garber%2C+Eric+A+E%3BO%27Brien%2C+Thomas+W&rft.aulast=Garber&rft.aufirst=Eric+A&rft.date=2008-03-01&rft.volume=91&rft.issue=2&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A rapid multiresidue method for determination of pesticides in fruits and vegetables by using acetonitrile extraction/partitioning and solid-phase extraction column cleanup. AN - 70716511; 18476358 AB - A modification of a rapid and inexpensive multiresidue method for determination of pesticides in fruits and vegetables (QuEChERS method) is presented. Samples were extracted by shaking with acetic acid-acetonitrile (1 + 99). Water was removed by liquid-liquid partitioning with magnesium sulfate and sodium acetate. The extract was subjected to a single solid-phase extraction (SPE) column cleanup, which produced a cleaner extract than did the dispersive SPE cleanup used in the original QuEChERS method. Recovery data were obtained for 316 pesticide residues, at levels ranging from 20 ppb to 1.0 ppm. Data were provided by 3 different laboratories. The modified QuEChERS method resulted in a 65% reduction in solvent usage, when compared with the traditional multiresidue methods previously used in our laboratories. JF - Journal of AOAC International AU - Schenck, Frank J AU - Brown, Amy N AU - Podhorniak, Lynda V AU - Parker, Alesia AU - Reliford, Michelle AU - Wong, Jon W AD - U.S. Food and Drug Administration, Southeast Regional Laboratory, Atlanta, GA 30309, USA. Frank.Schenck@fda.hhs.gov PY - 2008 SP - 422 EP - 438 VL - 91 IS - 2 SN - 1060-3271, 1060-3271 KW - Acetonitriles KW - 0 KW - Pesticide Residues KW - acetonitrile KW - Z072SB282N KW - Index Medicus KW - Vegetables -- chemistry KW - Solid Phase Extraction -- methods KW - Pesticide Residues -- analysis KW - Fruit -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70716511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=A+rapid+multiresidue+method+for+determination+of+pesticides+in+fruits+and+vegetables+by+using+acetonitrile+extraction%2Fpartitioning+and+solid-phase+extraction+column+cleanup.&rft.au=Schenck%2C+Frank+J%3BBrown%2C+Amy+N%3BPodhorniak%2C+Lynda+V%3BParker%2C+Alesia%3BReliford%2C+Michelle%3BWong%2C+Jon+W&rft.aulast=Schenck&rft.aufirst=Frank&rft.date=2008-03-01&rft.volume=91&rft.issue=2&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antisocial behavioral syndromes and past-year physical health among adults in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 70487391; 18348594 AB - To describe associations of DSM-IV antisocial personality disorder (ASPD), DSM-IV conduct disorder without progression to ASPD (CD-only), and syndromal antisocial behavior in adulthood without conduct disorder before age 15 years (AABS, not a DSM-IV diagnosis) with past-year physical health status and hospital care utilization in the general U.S. adult population. This report is based on the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093, response rate = 81%). Respondents were classified according to whether they met criteria for ASPD, AABS, CD-only, or no antisocial syndrome. Associations of antisocial syndromes with physical health status and care utilization were examined using normal theory and logistic regression. ASPD and AABS were significantly but modestly associated with total past-year medical conditions, coronary heart and gastrointestinal diseases, and numbers of inpatient hospitalizations, inpatient days, emergency department visits, and clinically significant injuries (all p < .05). ASPD was also associated with liver disease, arthritis, and lower scores on the Medical Outcomes Study 12-Item Short-Form Health Survey, version 2 (SF-12v2) physical component summary, role physical, and bodily pain scales (all p < .05). AABS was associated with noncoronary heart disease, lower scores on the SF-12v2 general health and vitality scales, and, among men, arthritis (all p < .05). CD-only was associated with single but not multiple inpatient hospitalizations, emergency department visits, and clinically significant injuries (all p < .05). Estimates of burden related to antisocial behavioral syndromes need to consider associated physical health problems. Prevention and treatment guidelines for injuries and common chronic diseases may need to address comorbid antisociality, and interventions targeting antisociality may need to consider general health status, including prevention and management of injuries and chronic diseases. JF - The Journal of clinical psychiatry AU - Goldstein, Risë B AU - Dawson, Deborah A AU - Chou, S Patricia AU - Ruan, W June AU - Saha, Tulshi D AU - Pickering, Roger P AU - Stinson, Frederick S AU - Grant, Bridget F AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. goldster@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 368 EP - 380 VL - 69 IS - 3 KW - Index Medicus KW - Mood Disorders -- diagnosis KW - Insurance, Health -- statistics & numerical data KW - Tobacco Use Disorder -- epidemiology KW - Anxiety Disorders -- diagnosis KW - Humans KW - Body Mass Index KW - Comorbidity KW - Adult KW - Tobacco Use Disorder -- diagnosis KW - Mood Disorders -- epidemiology KW - Adolescent KW - Anxiety Disorders -- epidemiology KW - United States -- epidemiology KW - Time Factors KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Male KW - Prevalence KW - Antisocial Personality Disorder -- epidemiology KW - Conduct Disorder -- diagnosis KW - Health Surveys KW - Health Status KW - Conduct Disorder -- epidemiology KW - Antisocial Personality Disorder -- diagnosis KW - Alcohol Drinking -- epidemiology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70487391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Antisocial+behavioral+syndromes+and+past-year+physical+health+among+adults+in+the+United+States%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Goldstein%2C+Ris%C3%AB+B%3BDawson%2C+Deborah+A%3BChou%2C+S+Patricia%3BRuan%2C+W+June%3BSaha%2C+Tulshi+D%3BPickering%2C+Roger+P%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Goldstein&rft.aufirst=Ris%C3%AB&rft.date=2008-03-01&rft.volume=69&rft.issue=3&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-22 N1 - Date created - 2008-04-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychiatry 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2017-01-18 ER - TY - JOUR T1 - Detection of melamine using commercial enzyme-linked immunosorbent assay technology. AN - 70484137; 18389705 AB - Recent cases of adulteration with melamine have led to the need for rapid and reliable screening methods. To meet this need, commercial enzyme-linked immunosorbent assay (ELISA) test kits for the detection of triazines were evaluated. The recently released Melamine Plate kit (Abraxis, Warminster, Pa.) displayed a limit of detection of 9 ng/ml for melamine in phosphate-buffered saline (PBS) and approximately 1 microg/ml for melamine added to dog food. An atrazine ELISA test kit produced by Abraxis required 0.2 mg/ml to generate a response more than four times the standard deviation from background. In contrast, with the EnviroGard Triazine Plate kit (Strategic Diagnostics, Inc., Newark, Del.), 1.5 mg/ml melamine in PBS generated a signal only one standard deviation from background, which was insufficient to define a limit of detection. Extraction based on dilution with 105 mM sodium phosphate/75 mM NaCl/2.5% nonfat milk/0.05% Tween 20 (UD) enabled detection of fivefold less melamine in dog food than did use of the procedure recommended by the manufacturer, which entailed extraction into 60% methanol, sonication, centrifugation, filtration, and further dilution into 10% methanol/PBS. Using the Abraxis Melamine ELISA, both extraction protocols yielded identical results with a dog food sample adulterated with melamine. The recovery of melamine spiked into gravy from dog food using UD was 74% +/- 4%. In conclusion, the recently released Abraxis ELISA for melamine proved to be a useful alternative to more cumbersome methods. JF - Journal of food protection AU - Garber, Eric A E AD - Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland 20740, USA. eric.garber@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 590 EP - 594 VL - 71 IS - 3 SN - 0362-028X, 0362-028X KW - Herbicides KW - 0 KW - Pesticide Residues KW - Reagent Kits, Diagnostic KW - Triazines KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Consumer Product Safety KW - Reproducibility of Results KW - Humans KW - Pesticide Residues -- analysis KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Triazines -- analysis KW - Herbicides -- analysis KW - Food Contamination -- analysis KW - Animal Feed -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70484137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Detection+of+melamine+using+commercial+enzyme-linked+immunosorbent+assay+technology.&rft.au=Garber%2C+Eric+A+E&rft.aulast=Garber&rft.aufirst=Eric+A&rft.date=2008-03-01&rft.volume=71&rft.issue=3&rft.spage=590&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-12 N1 - Date created - 2008-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug safety surveillance in China and other countries: a review and comparison. AN - 70477535; 18387057 AB - Drug safety and postmarketing surveillance have become important public health issues in China. This study reviews the relatively new drug safety surveillance system in China and compares it with the systems in the United States and Europe. An extensive literature review was conducted in the following four areas: 1) the organizational structure of the State Food and Drug Administration (SFDA) in China; 2) the development of an adverse drug reaction (ADR) monitoring system in China; 3) regulatory issues related to drug safety in China; and 4) similarities and differences between drug safety surveillance in China and surveillance in the United States and Europe. The SFDA oversees an extensive network of drug safety "watchdogs," including the China National Center for ADR Monitoring and 32 regional centers throughout China. China's system has faced a number of recent challenges. It has had to respond quickly to the withdrawal of various high-profile drugs like Vioxx (rofecoxib) and Baycol (cerivastatin) from other markets. Together with China's Ministry of Health, the SFDA has faced several unique drug safety events. Three of those events, involving the injectable form of the heartleaf houttuyinia herb (Yu Xing Cao), Armillarisni A injections, and clindamycin glucose infusions (Xinfu), are discussed. The rapid development of drug safety surveillance in China is manifested in extensive organizational structure, development of large databases, and laws and regulations supporting drug safety. The two major laws are the China Drug Administration Law issued in February 2001 and the Regulation for the Administration of ADR Reporting and Monitoring issued in March 2004. The study also discusses and compares recent developments in drug safety surveillance in the United States and the European Union. These developments will most likely have implications for the Chinese system in the near future. While postmarketing surveillance guidelines are not yet available in China, we fully expect their eventual issuance after adaptation to the particular culture and clinical practices in China. JF - Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research AU - Du, Wenmin AU - Guo, Jeff J AU - Jing, Yonghua AU - Li, Xing AU - Kelton, Christina M L AD - Shanghai Center for Adverse Drug Reaction Monitoring, Shanghai Food and Drug Administration, Shanghai, China. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - S130 EP - S136 VL - 11 Suppl 1 KW - Index Medicus KW - United States KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Europe KW - China KW - Drug-Related Side Effects and Adverse Reactions KW - Product Surveillance, Postmarketing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70477535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Value+in+health+%3A+the+journal+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research&rft.atitle=Drug+safety+surveillance+in+China+and+other+countries%3A+a+review+and+comparison.&rft.au=Du%2C+Wenmin%3BGuo%2C+Jeff+J%3BJing%2C+Yonghua%3BLi%2C+Xing%3BKelton%2C+Christina+M+L&rft.aulast=Du&rft.aufirst=Wenmin&rft.date=2008-03-01&rft.volume=11+Suppl+1&rft.issue=&rft.spage=S130&rft.isbn=&rft.btitle=&rft.title=Value+in+health+%3A+the+journal+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research&rft.issn=1524-4733&rft_id=info:doi/10.1111%2Fj.1524-4733.2008.00377.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-06 N1 - Date created - 2008-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1524-4733.2008.00377.x ER - TY - JOUR T1 - Compound cytotoxicity profiling using quantitative high-throughput screening. AN - 70391794; 18335092 AB - The propensity of compounds to produce adverse health effects in humans is generally evaluated using animal-based test methods. Such methods can be relatively expensive, low-throughput, and associated with pain suffered by the treated animals. In addition, differences in species biology may confound extrapolation to human health effects. The National Toxicology Program and the National Institutes of Health Chemical Genomics Center are collaborating to identify a battery of cell-based screens to prioritize compounds for further toxicologic evaluation. A collection of 1,408 compounds previously tested in one or more traditional toxicologic assays were profiled for cytotoxicity using quantitative high-throughput screening (qHTS) in 13 human and rodent cell types derived from six common targets of xenobiotic toxicity (liver, blood, kidney, nerve, lung, skin). Selected cytotoxicants were further tested to define response kinetics. qHTS of these compounds produced robust and reproducible results, which allowed cross-compound, cross-cell type, and cross-species comparisons. Some compounds were cytotoxic to all cell types at similar concentrations, whereas others exhibited species- or cell type-specific cytotoxicity. Closely related cell types and analogous cell types in human and rodent frequently showed different patterns of cytotoxicity. Some compounds inducing similar levels of cytotoxicity showed distinct time dependence in kinetic studies, consistent with known mechanisms of toxicity. The generation of high-quality cytotoxicity data on this large library of known compounds using qHTS demonstrates the potential of this methodology to profile a much broader array of assays and compounds, which, in aggregate, may be valuable for prioritizing compounds for further toxicologic evaluation, identifying compounds with particular mechanisms of action, and potentially predicting in vivo biological response. JF - Environmental health perspectives AU - Xia, Menghang AU - Huang, Ruili AU - Witt, Kristine L AU - Southall, Noel AU - Fostel, Jennifer AU - Cho, Ming-Hsuang AU - Jadhav, Ajit AU - Smith, Cynthia S AU - Inglese, James AU - Portier, Christopher J AU - Tice, Raymond R AU - Austin, Christopher P AD - NIH Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-3370, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 284 EP - 291 VL - 116 IS - 3 SN - 0091-6765, 0091-6765 KW - Xenobiotics KW - 0 KW - Index Medicus KW - cell viability KW - NTP 1,408 compound library KW - qHTS KW - RT-CES KW - 1,536-well KW - PubChem KW - Rats KW - Animals KW - Reproducibility of Results KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Humans KW - In Vitro Techniques KW - Mice KW - Toxicity Tests -- methods KW - Xenobiotics -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70391794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Compound+cytotoxicity+profiling+using+quantitative+high-throughput+screening.&rft.au=Xia%2C+Menghang%3BHuang%2C+Ruili%3BWitt%2C+Kristine+L%3BSouthall%2C+Noel%3BFostel%2C+Jennifer%3BCho%2C+Ming-Hsuang%3BJadhav%2C+Ajit%3BSmith%2C+Cynthia+S%3BInglese%2C+James%3BPortier%2C+Christopher+J%3BTice%2C+Raymond+R%3BAustin%2C+Christopher+P&rft.aulast=Xia&rft.aufirst=Menghang&rft.date=2008-03-01&rft.volume=116&rft.issue=3&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10727 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-14 N1 - Date created - 2008-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Ther. 1999 Sep;83(3):181-215 [10576292] Mutagenesis. 2007 Jan;22(1):5-13 [17142828] Biochem Biophys Res Commun. 2000 Jul 14;273(3):1095-8 [10891377] Int J Hyg Environ Health. 2003 Aug;206(4-5):437-45 [12971699] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] Toxicology. 2004 May 20;198(1-3):315-28 [15138058] Nature. 1970 Jul 11;227(5254):168-70 [4316953] Proc Natl Acad Sci U S A. 1984 Oct;81(20):6413-7 [6333682] Biochim Biophys Acta. 1989 May 9;988(2):185-220 [2541792] Mutat Res. 1990 Mar;238(2):99-172 [2407950] Methods Enzymol. 1990;192:280-300 [2074793] J Immunol Methods. 1993 Mar 15;160(1):81-8 [7680699] Cell Immunol. 1994 May;155(2):428-35 [8181074] Chem Res Toxicol. 2005 Feb;18(2):154-61 [15720119] Assay Drug Dev Technol. 2005 Apr;3(2):213-25 [15871695] Mutat Res. 2005 Nov 10;587(1-2):1-8 [16202644] Toxicol In Vitro. 2006 Aug;20(5):785-92 [16386874] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Curr Alzheimer Res. 2006 Sep;3(4):377-91 [17017868] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] Drug Metab Rev. 1999 Nov;31(4):917-70 [10575555] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.10727 ER - TY - JOUR T1 - Quantifying the risk for alcohol-use and alcohol-attributable health disorders: present findings and future research needs. AN - 70387802; 18336658 AB - The aim of the present review was to: (i) highlight epidemiological and other studies that have generated important data on the harmful patterns of drinking that increase the risk for chronic diseases, including alcohol dependence, and on the mechanisms by which alcohol produces and, in some instances, may protect against damage; and (ii) discuss a conceptual basis for quantifying risk criteria for alcohol-induced chronic disease based on the quantity, frequency, and pattern of drinking. The relationship between heavy drinking and risk for adverse health conditions such as alcoholic liver disease (ALD), dementia, and alcohol dependence is well known. However, not everyone who drinks chronically develops ALD or dementia, and the major risk factors for disease development and the mechanisms by which this occurs have remained unclear. Large-scale, general population-based studies have provided the evidence by which quantifying the frequency of a pattern of high-risk drinking can be related directly to risk and the severity of alcohol dependence. Cellular and molecular biology studies have identified the major pathways of alcohol metabolism and how genetics and the environment can interact in some individuals to further increase the risk of organ damage. Extant databases should allow scientists and clinicians jointly to develop the framework for quantifying the drinking patterns that increase the risk of alcohol-induced organ pathologies, to develop clinical practice guidelines, such as those used to diagnose other common complex diseases (e.g. diabetes and hypertension), and to propose future studies for refining such guidelines. Attention must be paid to comorbid conditions such as hepatitis B and C infections, HIV, obesity, and environmental exposures other than alcohol. Developing trait and state biomarkers is critical to the process of discovery and to fulfilling the promise of personalized medicine. JF - Journal of gastroenterology and hepatology AU - Li, Ting-Kai AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892-9304, USA. tkli@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - S2 EP - S8 VL - 23 Suppl 1 KW - Index Medicus KW - Biomedical Research -- trends KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Forecasting KW - Child KW - Adolescent KW - Male KW - Female KW - Risk Assessment KW - Alcohol Drinking -- adverse effects KW - Alcohol Drinking -- epidemiology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70387802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology+and+hepatology&rft.atitle=Quantifying+the+risk+for+alcohol-use+and+alcohol-attributable+health+disorders%3A+present+findings+and+future+research+needs.&rft.au=Li%2C+Ting-Kai&rft.aulast=Li&rft.aufirst=Ting-Kai&rft.date=2008-03-01&rft.volume=23+Suppl+1&rft.issue=&rft.spage=S2&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology+and+hepatology&rft.issn=1440-1746&rft_id=info:doi/10.1111%2Fj.1440-1746.2007.05298.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-29 N1 - Date created - 2008-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1440-1746.2007.05298.x ER - TY - JOUR T1 - Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. AN - 70384914; 17999989 AB - Chronic inflammation has been hypothesized to increase prostate cancer risk. Prostaglandin-endoperoxide synthase 2 (PTGS2) encodes the proinflammatory cyclooxygenase 2 enzyme believed to be the rate-limiting step in the synthesis of prostaglandins, important mediators of inflammation. We investigated associations between PTGS2 polymorphisms and prostate cancer risk among 2321 prostate cancer cases and 2560 controls in two large case-control studies nested within the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and the Cancer Prevention Study II Nutrition Cohort. Five single nucleotide polymorphisms (SNPs) (rs5277, rs20432, rs4648276, rs5275 and rs689470) were examined in SNP and haplotype analyses (five SNPs in PLCO and four SNPs in the Nutrition Cohort). In PLCO, the Ex10 +837 T>C marker (rs5275) was initially associated with prostate cancer risk (P-trend = 0.02) but became non-significant after adjustment for multiple comparisons (P = 0.08); this SNP showed no association with prostate cancer risk in the Nutrition Cohort (P-trend = 0.54) or in an analysis pooling the two cohorts (P-trend = 0.20). No other SNP was associated with prostate cancer risk in PLCO or the Nutrition Cohort individually or combined. Haplotype analyses suggested an association between PTGS2 variants in PLCO alone (global P = 0.007), but not in the Nutrition Cohort (global P = 0.78) or pooled analysis (global P = 0.18). In conclusion, despite the potential importance of inflammation in prostate carcinogenesis, results from our large study of five PTGS2 SNPs does not support a strong association between PTGS2 variants and prostate cancer risk in non-Hispanic white men. JF - Carcinogenesis AU - Danforth, Kim N AU - Hayes, Richard B AU - Rodriguez, Carmen AU - Yu, Kai AU - Sakoda, Lori C AU - Huang, Wen-Yi AU - Chen, Bingshu E AU - Chen, Jinbo AU - Andriole, Gerald L AU - Calle, Eugenia E AU - Jacobs, Eric J AU - Chu, Lisa W AU - Figueroa, Jonine D AU - Yeager, Meredith AU - Platz, Elizabeth A AU - Michaud, Dominique S AU - Chanock, Stephen J AU - Thun, Michael J AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. danfortk@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 568 EP - 572 VL - 29 IS - 3 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Index Medicus KW - Risk Factors KW - Humans KW - Cohort Studies KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Polymorphism, Single Nucleotide KW - Cyclooxygenase 2 -- genetics KW - Prostatic Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70384914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphic+variants+in+PTGS2+and+prostate+cancer+risk%3A+results+from+two+large+nested+case-control+studies.&rft.au=Danforth%2C+Kim+N%3BHayes%2C+Richard+B%3BRodriguez%2C+Carmen%3BYu%2C+Kai%3BSakoda%2C+Lori+C%3BHuang%2C+Wen-Yi%3BChen%2C+Bingshu+E%3BChen%2C+Jinbo%3BAndriole%2C+Gerald+L%3BCalle%2C+Eugenia+E%3BJacobs%2C+Eric+J%3BChu%2C+Lisa+W%3BFigueroa%2C+Jonine+D%3BYeager%2C+Meredith%3BPlatz%2C+Elizabeth+A%3BMichaud%2C+Dominique+S%3BChanock%2C+Stephen+J%3BThun%2C+Michael+J%3BHsing%2C+Ann+W&rft.aulast=Danforth&rft.aufirst=Kim&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-07 N1 - Date created - 2008-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analytical bias of cross-reactive polyclonal antibodies for environmental immunoassays of Alternaria alternata. AN - 70382832; 18036643 AB - Alternaria alternata is recognized as an important aeroallergen indoors and outdoors, and exposure to the fungus has been identified as a risk factor for asthma. Two recent publications concluded that 95% to 99% of American homes contained detectable amounts of Alternaria antigens when analyzed with a polyclonal antibody (pAb)-based ELISA. We investigated the cross-reactivity of the commercially available pAbs that were used in those studies. Reactivity to 24 fungal species commonly found in indoor environments was analyzed by inhibition ELISA by using solid-phase A alternata antigen. The pAbs were also tested by immunoblotting and halogen immunoassay for a subgroup of fungi. Spores of 7 fungi including species of Alternaria, Ulocladium, Stemphylium, Epicoccum, Drechslera, and Exserohilum strongly inhibited the binding of the pAbs when tested by ELISA. Six other fungi reacted in the ELISA at a lower level, and 11 fungal species including several Penicillium, Aspergillus, Fusarium, and Cladosporium species failed to show inhibition. The immunoblots and the halogen immunoassay staining confirmed the cross-reactivity patterns of the ELISA. The pAbs against A alternata were found to cross-react broadly with related and nonrelated fungi. The prevalence data previously reported for A alternata should be considered to be fungal-reactive rather than A alternata-specific. JF - The Journal of allergy and clinical immunology AU - Schmechel, Detlef AU - Green, Brett J AU - Blachere, Francoise M AU - Janotka, Erika AU - Beezhold, Donald H AD - Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. DSchmechel@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 763 EP - 768 VL - 121 IS - 3 KW - Antibodies, Fungal KW - 0 KW - Antigens, Fungal KW - Abridged Index Medicus KW - Index Medicus KW - Immunoblotting KW - Antibody Specificity KW - Air Pollution, Indoor KW - Cross Reactions KW - Immunoassay -- methods KW - Antigens, Fungal -- analysis KW - Antibodies, Fungal -- immunology KW - Alternaria -- isolation & purification KW - Air Microbiology KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70382832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Analytical+bias+of+cross-reactive+polyclonal+antibodies+for+environmental+immunoassays+of+Alternaria+alternata.&rft.au=Schmechel%2C+Detlef%3BGreen%2C+Brett+J%3BBlachere%2C+Francoise+M%3BJanotka%2C+Erika%3BBeezhold%2C+Donald+H&rft.aulast=Schmechel&rft.aufirst=Detlef&rft.date=2008-03-01&rft.volume=121&rft.issue=3&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-13 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimating the extent of reporting to FDA: a case study of statin-associated rhabdomyolysis. AN - 70367294; 18175291 AB - To estimate the extent of reporting to FDA through statin-associated rhabdomyolysis data. Data included incidence rates (IRs) of hospitalized rhabdomyolysis among statin users from a population-based study, and comparable reported AERS cases and national estimates of statin use from an AERS analysis. Using IRs, national estimates of statin use and average days supply per prescription, we estimated the number of US statin-associated cases of hospitalized rhabdomyolysis. We compared this estimate to the observed number of cases reported to FDA to evaluate the extent of reporting. We repeated this method for atorvastatin, cerivastatin, pravastatin, and simvastatin and statin combinations. We performed sensitivity analyses to check for biases such as misclassification of statin use and cohort selection bias. We evaluated potential time-dependent cerivastatin reporting by a "Dear Health Care Provider (DHCP)" letter. The estimated extent of reporting to FDA varied by statin (atorvastatin, 5.0%; cerivastatin, 31.2%; simvastatin, 14.2%; all four combined, 17.7%; and non-cerivastatin statins combined, 9.9%). No pravastatin-associated cohort cases occurred. Across a reasonable value range, sensitivity analyses did not significantly alter the results; overall the cohort was similar to national statin-users. There was a large increase in AERS reports after the cerivastatin DHCP letter and the estimated extent of reporting increased from 14.8 to 35.0%. The extent of reporting of adverse events to FDA varied by statin and may be influenced by publicity. For statins-associated rhabdomyolysis, the estimated extent of reporting appears to range from 5 to 30% but in the absence of stimulated reporting appears to be 5-15%. Copyright 2008 John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and drug safety AU - McAdams, Mara AU - Staffa, Judy AU - Dal Pan, Gerald AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. mara.mcadams@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 229 EP - 239 VL - 17 IS - 3 KW - Heptanoic Acids KW - 0 KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Pyridines KW - Pyrroles KW - Atorvastatin Calcium KW - 48A5M73Z4Q KW - Simvastatin KW - AGG2FN16EV KW - cerivastatin KW - AM91H2KS67 KW - Pravastatin KW - KXO2KT9N0G KW - Index Medicus KW - Pyrroles -- adverse effects KW - Simvastatin -- adverse effects KW - United States Food and Drug Administration -- statistics & numerical data KW - Humans KW - Retrospective Studies KW - Aged KW - Child KW - Heptanoic Acids -- adverse effects KW - Child, Preschool KW - Infant KW - Pravastatin -- adverse effects KW - Hospitalization KW - Adult KW - Incidence KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Pyridines -- adverse effects KW - Male KW - Female KW - Rhabdomyolysis -- epidemiology KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Rhabdomyolysis -- chemically induced KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70367294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Estimating+the+extent+of+reporting+to+FDA%3A+a+case+study+of+statin-associated+rhabdomyolysis.&rft.au=McAdams%2C+Mara%3BStaffa%2C+Judy%3BDal+Pan%2C+Gerald&rft.aulast=McAdams&rft.aufirst=Mara&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=1099-1557&rft_id=info:doi/10.1002%2Fpds.1535 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-10 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pds.1535 ER - TY - JOUR T1 - An evaluation of impact wrench vibration emissions and test methods. AN - 70367071; 18212244 AB - In the interest of providing more effective evaluations of impact wrench vibration exposures and the development of improved methods for measuring vibration emissions produced by these tools, this study focused on three variables: acceleration measured at the tool surface, vibration exposure duration per test trial, and the amount of torque required to unseat the nuts following a test trial. For this evaluation, six experienced male impact wrench operators used three samples each of five impact wrench models (four pneumatic models and one battery-powered model) in a simulated work task. The test setup and procedures were based on those provided by an International Organization for Standardization (ISO) Technical Committee overseeing the revision of ISO 8662-7. The work task involved the seating of 10 nuts onto 10 bolts mounted on steel plates. The results indicate that acceleration magnitudes vary not only by tool type but also by individual tools within a type. Thus, evaluators are cautioned against drawing conclusions based on small numbers of tools and/or tool operators. Appropriate sample sizes are suggested. It was further noted that evaluators could draw different conclusions if tool assessments are based on ISO-weighted acceleration as opposed to unweighted acceleration. As expected, vibration exposure durations varied by tool type and by test subject; duration means varied more for study participants than they did for tool types. For the 12 pneumatic tools evaluated in this study, torque varied directly with tool handle acceleration. Therefore, in order to reduce vibration exposure, tools should be selected and adjusted so that they produce no more than the needed torque for the task at hand. JF - The Annals of occupational hygiene AU - McDowell, Thomas W AU - Dong, R G AU - Xu, X AU - Welcome, D E AU - Warren, C AD - National Institute for Occupational Safety and Health (NIOSH), NIOSH Health Effects Lab, 1095 Willowdale Road, Morgantown, WV 26505, USA. tmcdowell@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 125 EP - 138 VL - 52 IS - 2 KW - Index Medicus KW - Humans KW - Torque KW - Equipment Design -- standards KW - Algorithms KW - Predictive Value of Tests KW - Equipment Safety -- standards KW - Male KW - Hand-Arm Vibration Syndrome -- prevention & control KW - Occupational Exposure -- statistics & numerical data KW - Hand -- physiology KW - Occupational Exposure -- adverse effects KW - Vibration -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70367071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=An+evaluation+of+impact+wrench+vibration+emissions+and+test+methods.&rft.au=McDowell%2C+Thomas+W%3BDong%2C+R+G%3BXu%2C+X%3BWelcome%2C+D+E%3BWarren%2C+C&rft.aulast=McDowell&rft.aufirst=Thomas&rft.date=2008-03-01&rft.volume=52&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmem064 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mem064 ER - TY - JOUR T1 - Toward better vaccine safety data and safer vaccination. AN - 70364537; 18310214 JF - Pediatrics AU - Braun, M Miles AD - Division of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, HFM-220, 1401 Rockville Pike, Rockville, MD 20852, USA. miles.braun@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 625 EP - 626 VL - 121 IS - 3 KW - Measles-Mumps-Rubella Vaccine KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Infant KW - Centers for Disease Control and Prevention (U.S.) KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Immunization Schedule KW - Male KW - Female KW - Risk Assessment KW - Child, Preschool KW - Vaccination -- methods KW - Purpura, Thrombocytopenic -- epidemiology KW - Measles-Mumps-Rubella Vaccine -- adverse effects KW - Vaccination -- adverse effects KW - Purpura, Thrombocytopenic -- etiology KW - Measles-Mumps-Rubella Vaccine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70364537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Toward+better+vaccine+safety+data+and+safer+vaccination.&rft.au=Braun%2C+M+Miles&rft.aulast=Braun&rft.aufirst=M&rft.date=2008-03-01&rft.volume=121&rft.issue=3&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2007-3846 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-20 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Pediatrics. 2008 Mar;121(3):e687-92 [18310189] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.2007-3846 ER - TY - JOUR T1 - Field measurement of diesel particulate matter emissions. AN - 70363757; 18281294 AB - A primary means to reduce environmental levels of diesel particulate matter (DPM) exposure to miners is to reduce the amount of DPM emission from the engine. A quick and economic method to estimate engine particulate emission levels has been developed. The method relies on the measurement of pressure increase across a filter element that is briefly used to collect a DPM sample directly from the engine exhaust. The method has been refined with the inclusion of an annular aqueous denuder to the tube which permits dry filter samples to be obtained without addition of dilution air. Tailpipe filter samples may then be directly collected in hot and water-supersaturated exhaust gas flows from water bath-cooled coal mine engines without the need for dilution air. Measurement of a differential pressure (DP) increase with time has been related to the mass of elemental carbon (EC) on the filter. Results for laboratory and field measurements of the method showed agreement between DP increase and EC collected on the filter with R(2) values >0.86. The relative standard deviation from replicate samples of DP and EC was 0.16 and 0.11, respectively. The method may also have applications beyond mining, where qualitative evaluation of engine emissions is desirable to determine if engine or control technology maintenance may be required. JF - The Annals of occupational hygiene AU - Volkwein, Jon C AU - Mischler, Steven E AU - Davies, Brian AU - Ellis, Clive AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, PO Box 18070, Pittsburgh, PA 15236, USA. jdv1@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 99 EP - 105 VL - 52 IS - 2 KW - Air Pollutants, Occupational KW - 0 KW - Gasoline KW - Particulate Matter KW - Vehicle Emissions KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Humans KW - Carbon -- adverse effects KW - Equipment Design -- standards KW - Mining KW - Carbon -- analysis KW - Environmental Monitoring -- statistics & numerical data KW - Male KW - Female KW - Environmental Monitoring -- methods KW - Air Pollutants, Occupational -- analysis KW - Gasoline -- adverse effects KW - Air Pollutants, Occupational -- adverse effects KW - Particulate Matter -- adverse effects KW - Particulate Matter -- analysis KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70363757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Field+measurement+of+diesel+particulate+matter+emissions.&rft.au=Volkwein%2C+Jon+C%3BMischler%2C+Steven+E%3BDavies%2C+Brian%3BEllis%2C+Clive&rft.aulast=Volkwein&rft.aufirst=Jon&rft.date=2008-03-01&rft.volume=52&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmem069 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mem069 ER - TY - JOUR T1 - Monitoring microbial populations on wide-body commercial passenger aircraft. AN - 70362978; 18316352 AB - Although exposure to bacteria has been assessed in cabin air previously, minimal numbers of samples have been collected in-flight. The purpose of this research was to comprehensively characterize bacterial concentrations in the aircraft cabin. Twelve randomly selected flights were sampled on Boeing-767 aircraft, each with a flight duration between 4.5 and 6.5 h. N-6 impactors were used to collect sequential, triplicate air samples in the front and rear of coach class during six sampling intervals throughout each flight: boarding, mid-climb, early cruise, mid-cruise, late cruise and deplaning. Comparison air samples were also collected inside and outside the airport terminals at the origin and destination cities. The MIXED procedure in SAS was used to model the mean and the covariance matrix of the natural log-transformed bacterial concentrations. A total of 513 airborne culturable bacterial samples were collected. During flight (mid-climb and cruise intervals), a model-adjusted geometric mean (GM) of 136 total colony-forming units per cubic meter of air sampled (CFU x m(-3)) and geometric standard deviation of 2.1 were observed. Bacterial concentrations were highest during the boarding (GM 290 CFU x m(-3)) and deplaning (GM 549 CFU x m(-3)) processes. Total bacterial concentrations observed during flight were significantly lower than GMs for boarding and deplaning (P values <0.0001-0.021) in the modeled results. Our findings highlight the fact that aerobiological concentrations can be dynamic and underscore the importance of appropriate sample size and design. The genera analysis indicates that passenger activity and high occupant density contribute to airborne bacterial generation. Overall, our research demonstrates that the bacteria recovered on observed flights were either common skin-surface organisms (primarily gram-positive cocci) or organisms common in dust and outdoor air. JF - The Annals of occupational hygiene AU - McKernan, Lauralynn Taylor AU - Wallingford, Kenneth M AU - Hein, Misty J AU - Burge, Harriet AU - Rogers, Christine A AU - Herrick, Robert AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. lmckernan@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 139 EP - 149 VL - 52 IS - 2 KW - Index Medicus KW - Micrococcus luteus -- isolation & purification KW - Colony Count, Microbial -- methods KW - Humans KW - Staphylococcus -- isolation & purification KW - Bacillus -- isolation & purification KW - Rhodococcus -- isolation & purification KW - Male KW - Female KW - Air Pollution, Indoor -- adverse effects KW - Air Pollution, Indoor -- analysis KW - Aircraft KW - Environmental Monitoring -- methods KW - Air Microbiology -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70362978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Monitoring+microbial+populations+on+wide-body+commercial+passenger+aircraft.&rft.au=McKernan%2C+Lauralynn+Taylor%3BWallingford%2C+Kenneth+M%3BHein%2C+Misty+J%3BBurge%2C+Harriet%3BRogers%2C+Christine+A%3BHerrick%2C+Robert&rft.aulast=McKernan&rft.aufirst=Lauralynn&rft.date=2008-03-01&rft.volume=52&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmem068 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mem068 ER - TY - JOUR T1 - Genome-wide association for methamphetamine dependence: convergent results from 2 samples. AN - 70362818; 18316681 AB - We can improve understanding of human methamphetamine dependence, and possibly our abilities to prevent and treat this devastating disorder, by identifying genes whose allelic variants predispose to methamphetamine dependence. To find "methamphetamine dependence" genes identified by each of 2 genome-wide association (GWA) studies of independent samples of methamphetamine-dependent individuals and matched controls. Replicated GWA results in each of 2 case-control studies. Japan and Taiwan. Individuals with methamphetamine dependence and matched control subjects free from psychiatric, substance abuse, or substance dependence diagnoses (N = 580). "Methamphetamine dependence" genes that were reproducibly identified by clusters of nominally positive single-nucleotide polymorphisms (SNPs) in both samples in ways that were unlikely to represent chance observations, based on Monte Carlo simulations that corrected for multiple comparisons, and subsets of "methamphetamine dependence" genes that were also identified by GWA studies of dependence on other addictive substances, success in quitting smoking, and memory. Genes identified by clustered nominally positive SNPs from both samples were unlikely to represent chance observations (Monte Carlo P < .00001). Variants in these "methamphetamine dependence" genes are likely to alter cell adhesion, enzymatic functions, transcription, cell structure, and DNA, RNA, and/or protein handling or modification. Cell adhesion genes CSMD1 and CDH13 displayed the largest numbers of clustered nominally positive SNPs. "Methamphetamine dependence" genes overlapped, to extents much greater than chance, with genes identified in GWA studies of dependence on other addictive substances, success in quitting smoking, and memory (Monte Carlo P range < .04 to < .00001). These data support polygenic contributions to methamphetamine dependence from genes that include those whose variants contribute to dependence on several addictive substances, success in quitting smoking, and mnemonic processes. JF - Archives of general psychiatry AU - Uhl, George R AU - Drgon, Tomas AU - Liu, Qing-Rong AU - Johnson, Catherine AU - Walther, Donna AU - Komiyama, Tokutaro AU - Harano, Mutsuo AU - Sekine, Yoshimoto AU - Inada, Toshiya AU - Ozaki, Norio AU - Iyo, Masaomi AU - Iwata, Nakao AU - Yamada, Mitsuhiko AU - Sora, Ichiro AU - Chen, Chih-Ken AU - Liu, Hsing-Cheng AU - Ujike, Hiroshi AU - Lin, Shih-Ku AD - Molecular Neurobiology Branch, National Institutes of Health Intramural Program, Department of Health and Human Services, Baltimore, Maryland 21224, USA. guhl@intra.nida.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 345 EP - 355 VL - 65 IS - 3 KW - CSMD1 protein, human KW - 0 KW - Cadherins KW - H-cadherin KW - Membrane Proteins KW - Methamphetamine KW - 44RAL3456C KW - Abridged Index Medicus KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Adult KW - Case-Control Studies KW - Membrane Proteins -- genetics KW - Genome KW - Cadherins -- genetics KW - Male KW - Female KW - Amphetamine-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70362818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Genome-wide+association+for+methamphetamine+dependence%3A+convergent+results+from+2+samples.&rft.au=Uhl%2C+George+R%3BDrgon%2C+Tomas%3BLiu%2C+Qing-Rong%3BJohnson%2C+Catherine%3BWalther%2C+Donna%3BKomiyama%2C+Tokutaro%3BHarano%2C+Mutsuo%3BSekine%2C+Yoshimoto%3BInada%2C+Toshiya%3BOzaki%2C+Norio%3BIyo%2C+Masaomi%3BIwata%2C+Nakao%3BYamada%2C+Mitsuhiko%3BSora%2C+Ichiro%3BChen%2C+Chih-Ken%3BLiu%2C+Hsing-Cheng%3BUjike%2C+Hiroshi%3BLin%2C+Shih-Ku&rft.aulast=Uhl&rft.aufirst=George&rft.date=2008-03-01&rft.volume=65&rft.issue=3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=1538-3636&rft_id=info:doi/10.1001%2Farchpsyc.65.3.345 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-24 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archpsyc.65.3.345 ER - TY - JOUR T1 - U.S. Food and Drug Administration approval: panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. AN - 70361752; 18316547 AB - To describe the Food and Drug Administration review and marketing approval considerations for panitumumab (Vectibix) for the third-line treatment of patients with epidermal growth factor receptor-expressing metastatic colorectal carcinoma. Food and Drug Administration reviewed a single, open-label, multicenter trial in which 463 patients with epidermal growth factor receptor-expressing metastatic colorectal cancer who had progressed on or following treatment with a regimen containing a fluoropyrimidine, oxaliplatin, and irinotecan were randomized (1:1) to receive best supportive care (BSC) with or without panitumumab (6 mg/kg every other week) administered until disease progression or intolerable toxicity. Progression and response were confirmed by an independent review committee masked to treatment assignment. At progression, patients in the BSC-alone arm were eligible to receive panitumumab. Although median progression-free survival (PFS) was similar in both treatment arms ( approximately 8 weeks), the mean PFS was approximately 50% longer among patients receiving panitumumab than among those receiving BSC alone (96 versus 60 days, respectively) and the objective response rate in patients receiving panitumumab was 8%. However, no difference in overall survival was shown between the two study arms. Panitumumab received accelerated approval based on improvement in PFS and an independently confirmed response rate of 8%, similar to that observed with other active agents at this advanced stage of disease. Confirmation of clinical benefit will be required for full approval. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Giusti, Ruthann M AU - Shastri, Kaushikkumar AU - Pilaro, Anne M AU - Fuchs, Chana AU - Cordoba-Rodriguez, Ruth AU - Koti, Kallappa AU - Rothmann, Mark AU - Men, Angela Yuxin AU - Zhao, Hong AU - Hughes, Monica AU - Keegan, Patricia AU - Weiss, Karen D AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0004, USA. ruthann.giusti@fda.hhs.gov Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 1296 EP - 1302 VL - 14 IS - 5 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - Organoplatinum Compounds KW - oxaliplatin KW - 04ZR38536J KW - irinotecan KW - 0H43101T0J KW - panitumumab KW - 6A901E312A KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Fluorouracil KW - U3P01618RT KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - United States KW - Disease-Free Survival KW - Organoplatinum Compounds -- administration & dosage KW - Lymphatic Metastasis KW - Humans KW - Disease Progression KW - Aged KW - Antibodies, Monoclonal -- administration & dosage KW - Camptothecin -- administration & dosage KW - Fluorouracil -- administration & dosage KW - United States Food and Drug Administration KW - Survival Rate KW - Adult KW - Camptothecin -- analogs & derivatives KW - Middle Aged KW - Chemotherapy, Adjuvant KW - Male KW - Liver Neoplasms -- metabolism KW - Receptor, Epidermal Growth Factor -- metabolism KW - Colorectal Neoplasms -- pathology KW - Colorectal Neoplasms -- metabolism KW - Lung Neoplasms -- secondary KW - Liver Neoplasms -- drug therapy KW - Drug Approval KW - Lung Neoplasms -- drug therapy KW - Liver Neoplasms -- secondary KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Colorectal Neoplasms -- drug therapy KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70361752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=U.S.+Food+and+Drug+Administration+approval%3A+panitumumab+for+epidermal+growth+factor+receptor-expressing+metastatic+colorectal+carcinoma+with+progression+following+fluoropyrimidine-%2C+oxaliplatin-%2C+and+irinotecan-containing+chemotherapy+regimens.&rft.au=Giusti%2C+Ruthann+M%3BShastri%2C+Kaushikkumar%3BPilaro%2C+Anne+M%3BFuchs%2C+Chana%3BCordoba-Rodriguez%2C+Ruth%3BKoti%2C+Kallappa%3BRothmann%2C+Mark%3BMen%2C+Angela+Yuxin%3BZhao%2C+Hong%3BHughes%2C+Monica%3BKeegan%2C+Patricia%3BWeiss%2C+Karen+D%3BPazdur%2C+Richard&rft.aulast=Giusti&rft.aufirst=Ruthann&rft.date=2008-03-01&rft.volume=14&rft.issue=5&rft.spage=1296&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-1354 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-23 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-1354 ER - TY - JOUR T1 - Improving pediatric dosing through pediatric initiatives: what we have learned. AN - 70361616; 18310202 AB - The goal was to review the impact of pediatric drug studies, as measured by the improvement in pediatric dosing and other pertinent information captured in the drug labeling. We reviewed the pediatric studies for 108 products submitted (July 1998 through October 2005) in response to a Food and Drug Administration written request for pediatric studies, and the subsequent labeling changes. We analyzed the dosing modifications and focused on drug clearance as an important parameter influencing pediatric dosing. The first 108 drugs with new or revised pediatric labeling changes had dosing changes or pharmacokinetic information (n = 23), new safety information (n = 34), information concerning lack of efficacy (n = 19), new pediatric formulations (n = 12), and extended age limits (n = 77). A product might have had > or = 1 labeling change. We selected specific examples (n = 16) that illustrate significant differences in pediatric pharmacokinetics. Critical changes in drug labeling for pediatric patients illustrate that unique pediatric dosing often is necessary, reflecting growth and maturational stages of pediatric patients. These changes provide evidence that pediatric dosing should not be determined by simply applying weight-based calculations to the adult dose. Drug clearance is highly variable in the pediatric population and is not readily predictable on the basis of adult information. JF - Pediatrics AU - Rodriguez, William AU - Selen, Arzu AU - Avant, Debbie AU - Chaurasia, Chandra AU - Crescenzi, Terrie AU - Gieser, Gerlie AU - Di Giacinto, Jennifer AU - Huang, Shiew-Mei AU - Lee, Peter AU - Mathis, Lisa AU - Murphy, Dianne AU - Murphy, Shirley AU - Roberts, Rosemary AU - Sachs, Hari Cheryl AU - Suarez, Sandra AU - Tandon, Veneeta AU - Uppoor, Ramana S AD - Food and Drug Administration, 5600 Fisher Lane, Parklawn Building, Room 13B-45, Rockville, MD 20850, USA. william.rodriguez@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 530 EP - 539 VL - 121 IS - 3 KW - Pharmaceutical Preparations KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Sensitivity and Specificity KW - Administration, Oral KW - Age Factors KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Humans KW - Body Surface Area KW - Child KW - Biological Availability KW - Child, Preschool KW - Registries KW - Infant KW - Drug Evaluation KW - United States Food and Drug Administration KW - Half-Life KW - Forecasting KW - Maximum Tolerated Dose KW - Adolescent KW - Male KW - Female KW - Pharmaceutical Preparations -- administration & dosage KW - Evaluation Studies as Topic KW - Drug Labeling -- legislation & jurisprudence KW - Pediatrics -- standards KW - Drug Labeling -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70361616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Improving+pediatric+dosing+through+pediatric+initiatives%3A+what+we+have+learned.&rft.au=Rodriguez%2C+William%3BSelen%2C+Arzu%3BAvant%2C+Debbie%3BChaurasia%2C+Chandra%3BCrescenzi%2C+Terrie%3BGieser%2C+Gerlie%3BDi+Giacinto%2C+Jennifer%3BHuang%2C+Shiew-Mei%3BLee%2C+Peter%3BMathis%2C+Lisa%3BMurphy%2C+Dianne%3BMurphy%2C+Shirley%3BRoberts%2C+Rosemary%3BSachs%2C+Hari+Cheryl%3BSuarez%2C+Sandra%3BTandon%2C+Veneeta%3BUppoor%2C+Ramana+S&rft.aulast=Rodriguez&rft.aufirst=William&rft.date=2008-03-01&rft.volume=121&rft.issue=3&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2007-1529 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-20 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.2007-1529 ER - TY - JOUR T1 - Evaluation of the rationale for concurrent use of N95 filtering facepiece respirators with loose-fitting powered air-purifying respirators during aerosol-generating medical procedures. AN - 70353718; 18313516 AB - The concurrent use of N95 filtering facepiece respirators with powered air-purifying respirators during aerosol-generating medical procedures in patients with severe respiratory pathogens has been promoted as offering additional protection against infectious agents. The purpose of this article is to examine the impact of this additional respiratory equipment upon protection and personal performance. The presumed additive protective effect of an N95 filtering facepiece respirator used concurrently with a powered air-purifying respirator has not been subjected to rigorous scientific investigation. The burden imposed by additional respiratory protective equipment should not be discounted, and the potentially minor contribution to protection may be offset by the negative impact on personal performance. Novel uses of protective equipment occasionally are spawned during crisis situations, but their generalized applicability to healthcare workers should ultimately be evidence-based. JF - American journal of infection control AU - Roberge, Raymond J AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA 15236, USA. dtn0@cdc.gov. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 135 EP - 141 VL - 36 IS - 2 KW - Aerosols KW - 0 KW - Index Medicus KW - Humans KW - Respiratory Protective Devices KW - Occupational Exposure -- prevention & control KW - Inhalation Exposure -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70353718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+infection+control&rft.atitle=Evaluation+of+the+rationale+for+concurrent+use+of+N95+filtering+facepiece+respirators+with+loose-fitting+powered+air-purifying+respirators+during+aerosol-generating+medical+procedures.&rft.au=Roberge%2C+Raymond+J&rft.aulast=Roberge&rft.aufirst=Raymond&rft.date=2008-03-01&rft.volume=36&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=American+journal+of+infection+control&rft.issn=1527-3296&rft_id=info:doi/10.1016%2Fj.ajic.2007.04.284 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-18 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ajic.2007.04.284 ER - TY - JOUR T1 - Migration of fluorochemical paper additives from food-contact paper into foods and food simulants. AN - 70349993; 18311629 AB - Fluorochemical-treated paper was tested to determine the amount of migration that occurs into foods and food-simulating liquids and the characteristics of the migration. Migration characteristics of fluorochemicals from paper were examined in Miglyol, butter, water, vinegar, water-ethanol solutions, emulsions and pure oil containing small amounts of emulsifiers. Additionally, microwave popcorn and chocolate spread were used to investigate migration. Results indicate that fluorochemicals paper additives do migrate to food during actual package use. For example, we found that microwave popcorn contained 3.2 fluorochemical mg kg(-1) popcorn after popping and butter contained 0.1 mg kg(-1) after 40 days at 4 degrees C. Tests also indicate that common food-simulating liquids for migration testing and package material evaluation might not provide an accurate indication of the amount of fluorochemical that actually migrates to food. Tests show that oil containing small amounts of an emulsifier can significantly enhance migration of a fluorochemical from paper. JF - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment AU - Begley, T H AU - Hsu, W AU - Noonan, G AU - Diachenko, G AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA. timothy.begley@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 384 EP - 390 VL - 25 IS - 3 KW - Fluorocarbons KW - 0 KW - Index Medicus KW - Consumer Product Safety KW - Food Technology KW - Adsorption KW - Paper KW - Fluorocarbons -- chemistry KW - Fluorocarbons -- analysis KW - Food Contamination -- analysis KW - Food Packaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70349993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.atitle=Migration+of+fluorochemical+paper+additives+from+food-contact+paper+into+foods+and+food+simulants.&rft.au=Begley%2C+T+H%3BHsu%2C+W%3BNoonan%2C+G%3BDiachenko%2C+G&rft.aulast=Begley&rft.aufirst=T&rft.date=2008-03-01&rft.volume=25&rft.issue=3&rft.spage=384&rft.isbn=&rft.btitle=&rft.title=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.issn=1944-0057&rft_id=info:doi/10.1080%2F02652030701513784 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-21 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/02652030701513784 ER - TY - JOUR T1 - Structural elucidation of critical residues involved in binding of human monoclonal antibodies to hepatitis C virus E2 envelope glycoprotein. AN - 70338669; 18230369 AB - Human monoclonal antibodies derived from B cells of HCV-infected individuals provide information on the immune response to native HCV envelope proteins as they are recognized during infection. Monoclonal antibodies have been useful in the determination of the function and structure of specific immunogenic domains of proteins and should also be useful for the structure/function characterization of HCV E1 and E2 envelope glycoproteins. The HCV E2 envelope glycoprotein has at least three immunodistinctive conformation domains, designated A, B, and C. Conformational epitopes within domain B and C are neutralizing antibody targets on HCV pseudoparticles as well as from infectious cell culture virus. In this study, a combination of differential surface modification and mass spectrometric limited proteolysis followed by alanine mutagenesis was used to provide insight into potential conformational changes within the E2 protein upon antibody binding. The arginine guanidine groups in the E2 protein were modified with CHD in both the affinity bound and free states followed by mass spectrometric analysis, and the regions showing protection upon antibody binding were identified. This protection can arise by direct contact between the residues and the monoclonal antibody, or by antibody-induced conformational changes. Based on the mass spectrometric data, site-directed mutagenesis experiments were performed which clearly identified additional amino acid residues on E2 distant from the site of antibody interaction, whose change to alanine inhibited antibody recognition by inducing conformational changes within the E2 protein. JF - Biochimica et biophysica acta AU - Iacob, Roxana E AU - Keck, Zhenyong AU - Olson, Oakley AU - Foung, Steven K H AU - Tomer, Kenneth B AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 530 EP - 542 VL - 1784 IS - 3 SN - 0006-3002, 0006-3002 KW - Antibodies, Monoclonal KW - 0 KW - Antigen-Antibody Complex KW - Hepatitis C Antibodies KW - Immunodominant Epitopes KW - Viral Envelope Proteins KW - glycoprotein E2, Hepatitis C virus KW - 157184-61-7 KW - Arginine KW - 94ZLA3W45F KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Arginine -- genetics KW - Arginine -- chemistry KW - Humans KW - Molecular Sequence Data KW - Hepatitis C Antibodies -- immunology KW - Amino Acid Sequence KW - Epitope Mapping KW - Protein Conformation KW - Antibodies, Monoclonal -- immunology KW - Immunodominant Epitopes -- immunology KW - Antigen-Antibody Reactions KW - Antigen-Antibody Complex -- immunology KW - Viral Envelope Proteins -- immunology KW - Viral Envelope Proteins -- chemistry KW - Immunodominant Epitopes -- genetics KW - Immunodominant Epitopes -- chemistry KW - Antigen-Antibody Complex -- chemistry KW - Viral Envelope Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70338669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Structural+elucidation+of+critical+residues+involved+in+binding+of+human+monoclonal+antibodies+to+hepatitis+C+virus+E2+envelope+glycoprotein.&rft.au=Iacob%2C+Roxana+E%3BKeck%2C+Zhenyong%3BOlson%2C+Oakley%3BFoung%2C+Steven+K+H%3BTomer%2C+Kenneth+B&rft.aulast=Iacob&rft.aufirst=Roxana&rft.date=2008-03-01&rft.volume=1784&rft.issue=3&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbapap.2007.12.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-15 N1 - Date created - 2008-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Biotechnol. 2002 Jan;20(1):49-62 [11876299] J Virol. 2002 Aug;76(15):7672-82 [12097581] J Exp Med. 2003 Mar 3;197(5):633-42 [12615904] Nature. 2003 Mar 20;422(6929):307-12 [12646921] Virology. 2003 Mar 15;307(2):255-65 [12667795] Biochimie. 2003 Mar-Apr;85(3-4):295-301 [12770768] J Biol Chem. 2003 Nov 7;278(45):44385-92 [12882983] J Virol. 2004 Mar;78(6):2994-3002 [14990718] J Virol. 2004 Jul;78(13):7257-63 [15194801] J Virol. 2004 Sep;78(17):9224-32 [15308717] J Gen Virol. 2004 Nov;85(Pt 11):3173-88 [15483230] Annu Rev Microbiol. 2004;58:391-424 [15487943] Biomed Mass Spectrom. 1984 Nov;11(11):601 [6525415] Science. 1989 Oct 6;246(4926):64-71 [2675315] Anal Chem. 1990 May 1;62(9):882-99 [2194402] Proc Natl Acad Sci U S A. 1990 Dec;87(24):9848-52 [1702219] Anal Biochem. 1991 Jul;196(1):120-5 [1888025] Anal Chem. 1991 Dec 15;63(24):1193A-1203A [1789447] Virology. 1992 Apr;187(2):573-90 [1312269] Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5630-4 [1608973] J Virol. 1993 May;67(5):2747-55 [8474172] Bioconjug Chem. 1994 Nov-Dec;5(6):583-90 [7873661] Nature. 1995 May 25;375(6529):291-8 [7753193] J Immunol. 1996 Jul 1;157(1):198-206 [8683115] J Virol. 1997 Feb;71(2):1443-52 [8995670] Virology. 1997 Apr 28;231(1):119-29 [9143310] J Virol. 1997 Nov;71(11):8377-84 [9343193] J Cell Biol. 1997 Nov 3;139(3):613-23 [9348279] J Viral Hepat. 1997;4(6):421-2 [9430363] Nature. 1998 Jun 18;393(6686):705-11 [9641684] Virology. 1998 Sep 15;249(1):32-41 [9740774] J Biol Chem. 1998 Nov 27;273(48):32088-95 [9822684] J Virol. 2005 Jan;79(2):1252-61 [15613352] Nat Rev Immunol. 2005 Mar;5(3):215-29 [15738952] J Virol. 2005 Apr;79(8):4870-6 [15795272] Nature. 2005 Aug 18;436(7053):946-52 [16107834] J Virol. 2005 Nov;79(21):13199-208 [16227243] Mass Spectrom Rev. 2006 Jul-Aug;25(4):663-82 [16477643] J Virol. 2006 Sep;80(17):8695-704 [16912317] Hepatology. 2006 Nov;44(5):1355-61 [17058236] J Am Soc Mass Spectrom. 2006 Nov;17(11):1560-9 [16875837] J Virol. 2007 Jan;81(2):1043-7 [17079294] J Virol. 2007 Feb;81(4):2031-8 [17108020] Novartis Found Symp. 2006;277:57-65; discussion 65-73, 251-3 [17319154] Science. 2000 Apr 14;288(5464):339-44 [10764648] J Immunol. 2000 Apr 15;164(8):4156-61 [10754311] J Virol. 2007 Aug;81(15):8101-11 [17522218] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5802-6 [10811876] Proteins. 2000 Aug 15;40(3):355-66 [10861927] J Gen Virol. 2000 Oct;81(Pt 10):2451-9 [10993933] J Virol. 2000 Nov;74(22):10407-16 [11044085] Anal Chem. 2001 Aug 15;73(16):4012-9 [11534730] Trends Biochem Sci. 2001 Nov;26(11):687-9 [11701329] Immunity. 2001 Dec;15(6):883-95 [11754811] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbapap.2007.12.015 ER - TY - JOUR T1 - Bronchiolitis obliterans in workers exposed to flavoring chemicals. AN - 70332218; 18303424 AB - Medical and environmental surveys at microwave popcorn plants and flavoring production plants have revealed a risk for bronchiolitis obliterans in workers exposed to flavoring chemicals. Workers in other food industries may also be at risk. This review summarizes the available information on disease characteristics and natural history and provides information on workplace characteristics associated with disease development. Investigations carried out in flavoring plants in California have identified severely affected current and former workers in four plants. Affected former workers have also been identified at a plant in the Netherlands that manufactured diacetyl, a predominant chemical in butter flavorings which has been implicated as a causal agent for lung disease in microwave popcorn workers. Workers who manufacture or use flavorings can be subjected to repeated intense exposures to flavoring chemicals. Affected workers can progress to severe fixed airways obstruction in as little as 7 months. Since medical treatment is generally ineffective, early identification of affected workers and removal from further exposure, along with control of exposures to protect coworkers, are essential to minimize this hazard. JF - Current opinion in pulmonary medicine AU - Kanwal, Richard AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. rkanwal@cdc.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 141 EP - 146 VL - 14 IS - 2 SN - 1070-5287, 1070-5287 KW - Flavoring Agents KW - 0 KW - Index Medicus KW - Global Health KW - Risk Factors KW - Humans KW - Incidence KW - Bronchiolitis Obliterans -- chemically induced KW - Flavoring Agents -- adverse effects KW - Occupational Exposure -- adverse effects KW - Bronchiolitis Obliterans -- epidemiology KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70332218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+pulmonary+medicine&rft.atitle=Bronchiolitis+obliterans+in+workers+exposed+to+flavoring+chemicals.&rft.au=Kanwal%2C+Richard&rft.aulast=Kanwal&rft.aufirst=Richard&rft.date=2008-03-01&rft.volume=14&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+pulmonary+medicine&rft.issn=10705287&rft_id=info:doi/10.1097%2FMCP.0b013e3282f52478 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-01 N1 - Date created - 2008-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MCP.0b013e3282f52478 ER - TY - JOUR T1 - Effect of surgical masks worn concurrently over N95 filtering facepiece respirators: extended service life versus increased user burden. AN - 70319000; 18287908 AB - Growing concern over the availability of Respiratory protective devices (eg, filtering facepiece Respirators), in the face of the probable extreme demand brought on by a pandemic influenza, has prompted the suggestion that useful life of N95 filtering facepiece Respirator can be extended by the concurrent use of a surgical mask as an outer protective barrier over the Respirator. Personal protective equipment generally places a strain on the user, and the detrimental physiological and psychological burdens normally imposed by Respirator use could be magnified by the addition of an extra layer of protection such as a surgical mask. The issue of this potentially increased burden of the concurrent use of a surgical facemask with an N95 filtering facepiece Respirator is investigated to afford users the necessary information to make informed decisions Regarding the use of this Respiratory personal protective equipment in the face of large-scale outbreaks of Respiratory pathogens. JF - Journal of public health management and practice : JPHMP AU - Roberge, Raymond J AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Pittsburgh, PA 15236, USA. dtn0@cdc.gov PY - 2008 SP - E19 EP - E26 VL - 14 IS - 2 KW - Health technology assessment KW - Equipment Design KW - Inhalation Exposure -- prevention & control KW - Risk Factors KW - Humans KW - Filtration -- instrumentation KW - Occupational Diseases -- prevention & control KW - Infection Control -- instrumentation KW - Respiratory Tract Diseases -- prevention & control KW - Respiratory Protective Devices KW - Infectious Disease Transmission, Patient-to-Professional -- prevention & control KW - Masks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70319000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+public+health+management+and+practice+%3A+JPHMP&rft.atitle=Effect+of+surgical+masks+worn+concurrently+over+N95+filtering+facepiece+respirators%3A+extended+service+life+versus+increased+user+burden.&rft.au=Roberge%2C+Raymond+J&rft.aulast=Roberge&rft.aufirst=Raymond&rft.date=2008-03-01&rft.volume=14&rft.issue=2&rft.spage=E19&rft.isbn=&rft.btitle=&rft.title=Journal+of+public+health+management+and+practice+%3A+JPHMP&rft.issn=1550-5022&rft_id=info:doi/10.1097%2F01.PHH.0000311904.41691.fd LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-29 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.PHH.0000311904.41691.fd ER - TY - JOUR T1 - Modeling and assaying dioxin-like biological effects for both dioxin-like and certain non-dioxin-like compounds. AN - 70280385; 18065775 AB - 13C NMR data have been correlated to Toxic Equivalency Factors (TEFs) of the 29 PCDDs, PCDFs, or PCBs for which non-zero TEFs have been defined. Such correlations are called quantitative spectrometric data-activity relationship (QSDAR) models. An improved QSDAR model predicted TEFs of 0.037 and 0.004, respectively, for 1,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 1,2,3,4,7-pentachlorodibenzo-p-dioxin (PeCDD), both among the 390 congeners for which zero value TEFs are assumed. A QSDAR model of Relative Potency (REP) values estimated the corresponding values as 0.115 and 0.020. Results from both models indicated that these two congeners may exhibit significant dioxin-like toxicity. If other such congeners have non-zero toxicity, TEF-based risk assessments of some dioxin-, furan-, or PCB-contaminated sites or foods may underestimate toxicity. Both models were extensively cross-validated and the TEF model was externally validated. We confirmed the predictions by an independent in vitro method, a luciferase gene expression assay based on mouse liver cells that found REPs of 0.027 and 0.013, respectively, for 1,3,7,8-TCDD and 1,2,3,4,7-PeCDD. The QSDAR-estimated and gene-expression assayed values agreed. The models were used to predict activity for an applicability domain including 108 non-2,3,7,8 dioxin, furan, or PCB congeners and 2,3,7,8-tetrachlorophenothiazine, a dioxin analog proposed as a drug candidate. This study showed that QSDAR prediction followed by a relatively inexpensive in vitro assay could be used to nominate a few candidates among hundreds for further investigation. It suggested that in silico and in vitro nomination protocols may facilitate practical risk assessment when chemical family members exhibit different degrees of toxicity operating via a common mechanism. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Wilkes, Jon G AU - Hass, Bruce S AU - Buzatu, Dan A AU - Pence, Lisa M AU - Archer, Jeffrey C AU - Beger, Richard D AU - Schnackenberg, Laura K AU - Halbert, Mary Kim AU - Jennings, Lisa AU - Kodell, Ralph L AD - Division of Systems Toxicology, Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock 72205-7199, USA. jone.wilkes@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 187 EP - 195 VL - 102 IS - 1 SN - 1096-6080, 1096-6080 KW - Dioxins KW - 0 KW - Environmental Pollutants KW - Furans KW - Receptors, Aryl Hydrocarbon KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Molecular Structure KW - Animals KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Humans KW - Liver -- metabolism KW - Mice KW - Risk Assessment KW - Quantitative Structure-Activity Relationship KW - Transfection KW - Liver -- drug effects KW - Genes, Reporter KW - Receptors, Aryl Hydrocarbon -- agonists KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Gene Expression Regulation -- drug effects KW - Cell Line KW - Furans -- chemistry KW - Environmental Pollutants -- toxicity KW - Dioxins -- chemistry KW - Polychlorinated Biphenyls -- toxicity KW - Polychlorinated Biphenyls -- chemistry KW - Furans -- toxicity KW - Biological Assay KW - Toxicity Tests -- methods KW - Environmental Pollutants -- chemistry KW - Dioxins -- toxicity KW - Models, Biological KW - Magnetic Resonance Spectroscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70280385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Modeling+and+assaying+dioxin-like+biological+effects+for+both+dioxin-like+and+certain+non-dioxin-like+compounds.&rft.au=Wilkes%2C+Jon+G%3BHass%2C+Bruce+S%3BBuzatu%2C+Dan+A%3BPence%2C+Lisa+M%3BArcher%2C+Jeffrey+C%3BBeger%2C+Richard+D%3BSchnackenberg%2C+Laura+K%3BHalbert%2C+Mary+Kim%3BJennings%2C+Lisa%3BKodell%2C+Ralph+L&rft.aulast=Wilkes&rft.aufirst=Jon&rft.date=2008-03-01&rft.volume=102&rft.issue=1&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-10 N1 - Date created - 2008-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurotoxic-related changes in tyrosine hydroxylase, microglia, myelin, and the blood-brain barrier in the caudate-putamen from acute methamphetamine exposure. AN - 70184821; 18081184 AB - Changes in the histological morphology of the caudate-putamen (CPu) were determined after a high-dose methamphetamine (METH) exposure in an effort to elucidate whether BBB disruption plays a role in CPu neurotoxicity. This was accomplished by evaluating the tyrosine hydroxylase immunoreactivity (TH-IR), isolectin B4 reactivity, Black Gold II (BG-II) and Fluoro-Jade C (FJ-C) staining, and immunoreactivity to mouse immunoglobulin G (IgG-IR) in adult male mice at 90-min, 4-h, 12-h, 1-day, and 3-day post-METH exposure. The IgG-IR indicated that the BBB was only modestly altered in the CPu at time points after neurodegeneration occurred and dependent on hyperthermia and status epilepticus. The modest CPu IgG-IR changes observed in the perivascular areas indicated that immunoglobulins were present on some CPu microglia 1 day or more after METH. The first signs of CPu damage were swellings in the TH-IR axons, myelin damage, and a few degenerating neurons at 4-h post-METH. The loss of TH-IR was dependent on hyperthermia but not seizures or CPu neurodegeneration, and the TH-IR was virtually absent throughout the CPu within 12 h. Surprisingly, signs of FJ-C labeling (degenerating) axons in the CPu were seen only in the regions of pronounced somatic neurodegeneration and independent of TH-IR loss. Microglial activation did not occur until 1 day or more post-METH. In summary, a major BBB disruption within the CPu does not directly contribute to neurotoxicity in this single high-dose METH exposure. However, seizure activity produced or exacerbated by amygdalar BBB disruption can significantly increase CPu somatic neurodegeneration (but not affect dopamine (DA) terminal damage). The time course of microglial activation indicates a response to the neurodegeneration, myelin damage, and/or damaged DA terminals after loss of TH-IR. (c) 2007 Wiley-Liss, Inc. JF - Synapse (New York, N.Y.) AU - Bowyer, John F AU - Robinson, Bonnie AU - Ali, Syed AU - Schmued, Larry C AD - Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. john.bowyer@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 193 EP - 204 VL - 62 IS - 3 SN - 0887-4476, 0887-4476 KW - Central Nervous System Stimulants KW - 0 KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Mice, Inbred C57BL KW - Nerve Degeneration -- chemically induced KW - Dopamine -- metabolism KW - Disease Models, Animal KW - Corpus Striatum -- drug effects KW - Mice KW - Corpus Striatum -- pathology KW - Serotonin -- metabolism KW - Time Factors KW - Male KW - Blood-Brain Barrier -- drug effects KW - Tyrosine 3-Monooxygenase -- metabolism KW - Central Nervous System Stimulants -- toxicity KW - Neostriatum -- drug effects KW - Myelin Sheath -- drug effects KW - Microglia -- drug effects KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70184821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Neurotoxic-related+changes+in+tyrosine+hydroxylase%2C+microglia%2C+myelin%2C+and+the+blood-brain+barrier+in+the+caudate-putamen+from+acute+methamphetamine+exposure.&rft.au=Bowyer%2C+John+F%3BRobinson%2C+Bonnie%3BAli%2C+Syed%3BSchmued%2C+Larry+C&rft.aulast=Bowyer&rft.aufirst=John&rft.date=2008-03-01&rft.volume=62&rft.issue=3&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-11 N1 - Date created - 2008-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene-environment interactions in the development of complex disease phenotypes. AN - 69145908; 18441400 AB - The lack of knowledge about the earliest events in disease development is due to the multi-factorial nature of disease risk. This information gap is the consequence of the lack of appreciation for the fact that most diseases arise from the complex interactions between genes and the environment as a function of the age or stage of development of the individual. Whether an environmental exposure causes illness or not is dependent on the efficiency of the so-called "environmental response machinery" (i.e., the complex of metabolic pathways that can modulate response to environmental perturbations) that one has inherited. Thus, elucidating the causes of most chronic diseases will require an understanding of both the genetic and environmental contribution to their etiology. Unfortunately, the exploration of the relationship between genes and the environment has been hampered in the past by the limited knowledge of the human genome, and by the inclination of scientists to study disease development using experimental models that consider exposure to a single environmental agent. Rarely in the past were interactions between multiple genes or between genes and environmental agents considered in studies of human disease etiology. The most critical issue is how to relate exposure-disease association studies to pathways and mechanisms. To understand how genes and environmental factors interact to perturb biological pathways to cause injury or disease, scientists will need tools with the capacity to monitor the global expression of thousands of genes, proteins and metabolites simultaneously. The generation of such data in multiple species can be used to identify conserved and functionally significant genes and pathways involved in gene-environment interactions. Ultimately, it is this knowledge that will be used to guide agencies such as the U.S. Department of Health and Human Services in decisions regarding biomedical research funding and policy. JF - International journal of environmental research and public health AU - Ramos, Rosemarie G AU - Olden, Kenneth AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD- NH04, Box 12233, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 4 EP - 11 VL - 5 IS - 1 KW - Index Medicus KW - Phenotype KW - Occupational Diseases -- genetics KW - Environmental Health -- trends KW - Disease Susceptibility -- epidemiology KW - Humans KW - Occupational Diseases -- epidemiology KW - Chronic Disease KW - Research -- trends KW - Environmental Exposure KW - Genetic Predisposition to Disease -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69145908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Gene-environment+interactions+in+the+development+of+complex+disease+phenotypes.&rft.au=Ramos%2C+Rosemarie+G%3BOlden%2C+Kenneth&rft.aulast=Ramos&rft.aufirst=Rosemarie&rft.date=2008-03-01&rft.volume=5&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=1660-4601&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-11 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1999 Dec 10;83(6):743-9 [10597189] Science. 2001 Feb 16;291(5507):1304-51 [11181995] Am J Ind Med. 2001 Mar;39(3):286-91 [11241561] Nat Rev Genet. 2000 Nov;1(2):149-53 [11253655] Toxicol Appl Pharmacol. 2001 Apr 1;172(1):75-82 [11264025] Biochim Biophys Acta. 2001;1471(2):C1-10 [11342183] Am J Public Health. 2001 Dec;91(12):1964-7 [11726375] Eur Respir J Suppl. 2001 Sep;32:127s-133s [11816820] J Immunol. 1999 Aug 1;163(3):1647-53 [10415070] Am J Hum Genet. 1962 Dec;14:353-62 [13937884] J Occup Environ Hyg. 2004 Oct;1(10):648-59 [15631056] Transpl Immunol. 2005 Aug;14(3-4):175-82 [15982560] J Occup Environ Hyg. 2005 Jun;2(6):D48-50 [16020086] Trends Immunol. 2005 Oct;26(10):543-9 [16099719] Nature. 2005 Oct 27;437(7063):1299-320 [16255080] Diabetes. 2005 Dec;54 Suppl 2:S125-36 [16306330] Science. 2005 Nov 25;310(5752):1325-6 [16311335] J Occup Environ Med. 2006 Feb;48(2):204-11 [16474270] Am J Prev Med. 2006 Aug;31(2):109-17 [16829327] Ann N Y Acad Sci. 2006 Sep;1076:703-6 [17119247] Lancet. 2007 Mar 10;369(9564):844-9 [17350453] Eur Respir J. 2007 Apr;29(4):793-803 [17400878] Int J Cancer. 2007 Jun 15;120(12):2739-43 [17290392] Am J Health Promot. 2007 Mar-Apr;21(4 Suppl):326-34 [17465178] Ann Allergy Asthma Immunol. 2007 May;98(5):455-63 [17521030] Circulation. 2007 Jun 5;115(22):2878-901 [17515457] Diabetes Obes Metab. 2007 Jul;9(4):548-57 [17587397] Proc Am Thorac Soc. 2007 Jul;4(3):221-5 [17607003] Ind Health. 2007 Jun;45(3):379-87 [17634686] Stroke. 2007 Aug;38(8):2221-7 [17600228] J Allergy Clin Immunol. 2007 Aug;120(2):322-8 [17543375] Environ Health Perspect. 2007 Sep;115(9):1264-70 [17805414] Inhal Toxicol. 2007;19 Suppl 1:161-75 [17886064] Int J Mol Med. 2007 Nov;20(5):703-7 [17912464] Occup Environ Med. 2007 Nov;64(11):717-8 [17951339] Diabet Med. 2007 Nov;24(11):1187-91 [17894829] Am J Med Genet. 2002 May 30;115(1):8-17 [12116172] Mol Cell Biochem. 2002 May-Jun;234-235(1-2):219-24 [12162437] Am J Prev Med. 2003 Feb;24(2):136-42 [12568819] EHP Toxicogenomics. 2003 Jan;111(1T):15-28 [12735106] JAMA. 2003 Aug 20;290(7):891-7 [12928465] Scand J Work Environ Health. 2004 Feb;30(1):71-9 [15018031] Int J Occup Environ Health. 2004 Jan-Mar;10(1):22-5 [15070022] Int J Occup Med Environ Health. 2004;17(1):103-10 [15212212] Am Rev Respir Dis. 1989 Jun;139(6):1479-86 [2729754] Environ Health Perspect. 1993 Apr 22;101(1):6-7 [8513765] Science. 1993 Oct 8;262(5131):242-4 [8105536] Cancer Epidemiol Biomarkers Prev. 1994 Sep;3(6):471-7 [8000297] J Mol Med (Berl). 1995 Aug;73(8):381-93 [8528740] DNA Cell Biol. 1996 Apr;15(4):273-80 [8639263] Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1076-81 [8887610] Environ Health Perspect. 1996 Oct;104 Suppl 5:937-43 [8933038] Science. 1997 Oct 24;278(5338):569-70 [9381162] Nat Genet. 1998 Feb;18(2):91-3 [9462728] Environ Health Perspect. 1998 Jul;106(7):365-8 [9637792] Am J Ind Med. 1998 Oct;34(4):318-24 [9750937] Eur Respir J. 1998 Dec;12(6):1463-75 [9877510] JAMA. 1999 Jan 27;281(4):341-6 [9929087] Toxicol Sci. 1999 Feb;47(2):135-43 [10220849] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514] Science. 2000 Jul 28;289(5479):536-7 [10939962] Environ Health Perspect. 2000 Aug;108 Suppl 4:675-84 [10931786] Mutat Res. 2001 Jan 25;473(1):3-10 [11166022] Nature. 2001 Feb 15;409(6822):860-921 [11237011] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - UVA photoirradiation of oxygenated benz[a]anthracene and 3-methylcholanthene--generation of singlet oxygen and induction of lipid peroxidation. AN - 69145780; 18441402 AB - Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants and potentially pose a health risk to humans. Although the biological and toxicological activities, including metabolism, mutagenicity, and carcinogenicity, of PAHs have been thoroughly studied, their phototoxicity and photo-induced biological activity have not been well examined. We have long been interested in phototoxicity of PAHs and their derivatives induced by irradiation with UV light. In this paper we report the photoirradiation of a series of oxygenated benz[a]anthracene (BA) and 3-methylcholanthene (3-MC) by UVA light in the presence of a lipid, methyl linoleate. The studied PAHs include 2-hydroxy-BA (2-OH-BA), 3-hydroxy-BA (3-OH-BA), 5-hydroxymethyl-BA (5- CH2OH-BA), 7-hydroxymethyl-BA (7-CH2OH-BA), 12-hydroxymethyl-BA (12-CH2OH-BA), 7-hydroxymethyl-12- methyl-BA (7-CH2OH-12-MBA), 5-formyl-BA (5-CHO-BA), BA 5,6-cis-dihydrodiol (BA 5,6-cis-diol), 1-hydroxy-3- methylcholanthene (1-OH-3-MC), 1-keto-3-methylcholanthene (1-keto-3-MC), and 3-MC 1,2-diol. The results indicate that upon photoirradiation by UVA at 7 and 21 J/cm2, respectively all these compounds induced lipid peroxidation and exhibited a relationship between the dose of the light and the level of lipid peroxidation induced. To determine whether or not photoirradiation of these compounds by UVA light produces ROS, an ESR spin-trap technique was employed to provide direct evidence. Photoirradiation of 3-keto-3-MC by UVA (at 389 nm) in the presence of 2,2,6,6-tetramethylpiperidine (TEMP), a specific probe for singlet oxygen, resulted in the formation of TEMPO, indicating that singlet oxygen was generated. These overall results suggest that UVA photoirradiation of oxygenated BA and 3-methylcholanthrene generates singlet oxygen, one of the reactive oxygen species (ROS), which induce lipid peroxidation. JF - International journal of environmental research and public health AU - Yin, Jun-Jie AU - Xia, Qingsu AU - Cherng, Shu-Hui AU - Tang, I-Wah AU - Fu, Peter P AU - Lin, Ge AU - Yu, Hongtao AU - Sáenz, Diógenes Herreño AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 26 EP - 31 VL - 5 IS - 1 KW - Benz(a)Anthracenes KW - 0 KW - Linoleic Acids KW - Singlet Oxygen KW - 17778-80-2 KW - methyl linoleate KW - 24N6726DE5 KW - Methylcholanthrene KW - 56-49-5 KW - benz(a)anthracene KW - C5PLF6152K KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Molecular Structure KW - Linoleic Acids -- radiation effects KW - Electron Spin Resonance Spectroscopy KW - Singlet Oxygen -- chemistry KW - Linoleic Acids -- chemistry KW - Lipid Peroxidation -- radiation effects KW - Ultraviolet Rays KW - Methylcholanthrene -- analogs & derivatives KW - Benz(a)Anthracenes -- radiation effects KW - Oxygen -- chemistry KW - Methylcholanthrene -- chemistry KW - Benz(a)Anthracenes -- chemistry KW - Methylcholanthrene -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69145780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=UVA+photoirradiation+of+oxygenated+benz%5Ba%5Danthracene+and+3-methylcholanthene--generation+of+singlet+oxygen+and+induction+of+lipid+peroxidation.&rft.au=Yin%2C+Jun-Jie%3BXia%2C+Qingsu%3BCherng%2C+Shu-Hui%3BTang%2C+I-Wah%3BFu%2C+Peter+P%3BLin%2C+Ge%3BYu%2C+Hongtao%3BS%C3%A1enz%2C+Di%C3%B3genes+Herre%C3%B1o&rft.aulast=Yin&rft.aufirst=Jun-Jie&rft.date=2008-03-01&rft.volume=5&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=1660-4601&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-11 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biosci Biotechnol Biochem. 2000 May;64(5):1044-6 [10879477] Photochem Photobiol. 2007 Mar-Apr;83(2):409-24 [17576350] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2002 Nov;20(2):149-83 [12515673] Biochim Biophys Acta. 2004 Jan 30;1608(1):63-73 [14741586] Mutat Res. 2004 Aug 8;562(1-2):143-50 [15279837] Nature. 1976 Sep 30;263(5576):442-3 [972689] Lancet. 1980 Apr 5;1(8171):732-5 [6103156] Carcinogenesis. 1982;3(2):215-7 [7067048] Anal Biochem. 1987 Jun;163(2):343-9 [3116881] Mutat Res. 1989 Oct;216(5):231-42 [2552308] Chem Res Toxicol. 1992 Mar-Apr;5(2):220-6 [1643251] Mutat Res. 1992 Nov;298(1):31-41 [1279414] J Mol Med (Berl). 1996 Jun;74(6):297-312 [8862511] Environ Health Perspect. 1996 Nov;104(11):1166-70 [8959405] Chem Res Toxicol. 1999 Jan;12(1):1-18 [9894013] Chem Res Toxicol. 2005 Feb;18(2):129-38 [15720116] Toxicol Lett. 2006 May 5;163(1):30-43 [16384671] Int J Environ Res Public Health. 2005 Apr;2(1):114-22 [16705809] Toxicol Ind Health. 2006 May;22(4):147-56 [16786836] Int J Environ Res Public Health. 2006 Jun;3(2):191-5 [16823092] Int J Environ Res Public Health. 2006 Dec;3(4):348-54 [17159277] Toxicol Lett. 2007 Jan 30;168(2):165-75 [17197137] Int J Environ Res Public Health. 2007 Jun;4(2):153-7 [17617679] Methods Enzymol. 2000;319:290-6 [10907520] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Keeping a Safe Distance: Individualism and the Less Punitive Public AN - 61677567; 200819395 AB - This article will address individual differences in punitiveness or 'get tough' attitudes towards lawbreakers, but will do so by looking in depth at the nature of worldviews that have been identified as decidedly forgiving. The aim is to generate new hypotheses through a grounded narrative analysis regarding a dimension of public sensibilities towards crime-leniency-about which we know very little. I conclude that social identity is an important aspect of merciful worldviews, and that a precondition of a forgiving orientation may be a focus on individual agency. This analysis is supported by quantitative tests of new hypotheses to emerge. This article contributes to the more complex picture of differentiated public opinion to crime and criminal justice that has emerged recently in the literature. Adapted from the source document. JF - British Journal of Criminology AU - King, Anna AD - Rutgers University, Center for Mental Health Services and Criminal Justice Research, 176 Ryders Lane, New Brunswick, NJ 08901, USA aking@ifh.rutgers.edu Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 190 EP - 208 PB - Oxford University Press, UK VL - 48 IS - 2 SN - 0007-0955, 0007-0955 KW - Attitudes KW - Individualism KW - Punishment KW - Criminal Justice Policy KW - Public Opinion KW - article KW - 2147: social problems and social welfare; sociology of crime UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61677567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Criminology&rft.atitle=Keeping+a+Safe+Distance%3A+Individualism+and+the+Less+Punitive+Public&rft.au=King%2C+Anna&rft.aulast=King&rft.aufirst=Anna&rft.date=2008-03-01&rft.volume=48&rft.issue=2&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Criminology&rft.issn=00070955&rft_id=info:doi/10.1093%2Fbjc%2Fazm069 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-07-03 N1 - Number of references - 53 N1 - Last updated - 2016-09-28 N1 - CODEN - BJCDAR N1 - SubjectsTermNotLitGenreText - Punishment; Individualism; Attitudes; Criminal Justice Policy; Public Opinion DO - http://dx.doi.org/10.1093/bjc/azm069 ER - TY - JOUR T1 - Sex and Race Differences in Mental Health Symptoms in Juvenile Justice: The MAYSI-2 National Meta-Analysis AN - 57248970; 200815537 AB - Objective: Studies have suggested a high prevalence of mental health symptoms among youths in the juvenile justice system, with the highest prevalence among girls and whites compared to boys and other races. This multisite, archival study examined whether sex and race differences, when they exist, were consistent across U.S. juvenile justice programs. Method: Data included scores on the Massachusetts Youth Screening Instrument-Version 2 (MAYSI-2) for 70,423 youths from 283 juvenile justice probation, detention, or corrections programs. A meta-analytic technique investigated the consistency of effect sizes for sex and race/ethnic differences across sites in self-reported mental health problems. Results: Across sites, girls on average were 1.8 (95% confidence interval 0.98-1.10) to 2.4 (95% confidence interval 2.38-2.48) times as likely as boys to have clinical elevations on all applicable MAYSI-2 scales except the Alcohol/Drug Use scale. On the Alcohol/Drug Use scale, a sex effect existed but only among younger youths. Whites were more likely to have clinical elevations than blacks or Hispanics, but surprisingly disparities varied across mental health categories and varied considerably across sites. Conclusion: At the aggregate level, 72% of girls and 63% of boys had a clinical elevation on at least one MAYSI-2 scale. Our meta-analytic technique indicated that the sex differences across sites were even larger than these numbers imply. Conversely and counter to existing evidence, race-related differences were generally small or nonexistent. Whites were more likely to have alcohol and drug problems and suicide ideation, but not more likely to have symptoms of depression, anxiety, or thought disturbance than blacks or Hispanics. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Vincent, Gina M AU - Grisso, Thomas AU - Terry, Anna AU - Banks, Steven AD - Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 gina.vincent@umassmed.edu Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 282 EP - 290 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 3 SN - 0890-8567, 0890-8567 KW - Massachusetts Youth Screening Instrument-Version 2, juvenile justice, mental disorder, race, sex KW - Mental illness KW - Racial differences KW - Delinquents KW - Gender differences KW - Juvenile justice KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57248970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Sex+and+Race+Differences+in+Mental+Health+Symptoms+in+Juvenile+Justice%3A+The+MAYSI-2+National+Meta-Analysis&rft.au=Vincent%2C+Gina+M%3BGrisso%2C+Thomas%3BTerry%2C+Anna%3BBanks%2C+Steven&rft.aulast=Vincent&rft.aufirst=Gina&rft.date=2008-03-01&rft.volume=47&rft.issue=3&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2Fchi.0b013e318160d516 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Racial differences; Adolescents; Mental illness; Juvenile justice; Gender differences; Delinquents DO - http://dx.doi.org/10.1097/chi.0b013e318160d516 ER - TY - RPRT T1 - FOREWORD AN - 236520695 AB - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236520695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-03-01&rft.volume=&rft.issue=539&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2008 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - MULTIGENERATIONAL REPRODUCTIVE TOXICOLOGY: STUDY OF GENISTEIN (CAS NO. 446-72-0) IN SPRAGUE-DAWLEY RATS (FEED STUDY) AN - 236459805; 18685713 AB - Genistein is an isoflavone that occurs in soy products including soy-based infant formulas. Genistein is one of a class of chemicals known as "environmental estrogens," which can affect the hormone activities and possibly reproductive function of wildlife and humans through exposure. The NTP conducted a series of studies on three such chemicals to detect if exposure to such chemicals over the course of multiple generations could have any cumulative effect on animals' reproductive systems. This report describes the results of a set of studies in which several generations of rats were exposed to genistein through their feed and/or through exposure from their mothers through gestation and weaning. The study extended over five generations of rats following a parental group of rats that were exposed to genistein in their feed starting at the age of 6 weeks. The first and second generations of offspring were exposed to genistein during conception through their mothers, during weaning through their mothers' milk, and during their lifetimes through feed containing genistein. The third generation was exposed just during gestation and weaning, and the fourth and fifth generations were not exposed directly, to see if any carryover effects resided from exposure of earlier generations. The dosed feed contained 5, 100, or 500 parts per million (ppm) of genistein. The primary measures examined during each generation were body weights, development of reproductive organs, and number of offspring per litter after each cycle of mating. Female rats given 500 ppm in their feed had lower body weights, accelerated sexual maturation, and altered estrous cyclicity compared to unexposed animals. Male rats given 500 ppm in the feed had lower body weights in the first generation but not in the second generation, with similar chemical exposure. For animals continuously exposed to genistein, there was some reduction in litter size in the first two generations. Male rats exposed to 100 or 500 ppm had increased rates of mammary gland hyperplasia and calcification of renal tubules. In the later generations, the only observed effects on offspring of exposed animals were smaller body weight gains in pups before weaning. We conclude that exposure to 500 ppm of genistein caused lower body weights and some alterations in the reproductive system of female rats. Exposure to genistein caused lower body weights in one generation of male rats and increases in mammary gland hyperplasia and renal tubule calcification. Except for lower body weights in pups, there was no evidence for a carryover of genistein effects into unexposed generations. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1 EP - 266 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Carcinogens KW - Phytoestrogens KW - Genistein KW - Toxicology KW - Rodents KW - Chemicals KW - Animal reproduction KW - Animals KW - Pituitary Neoplasms -- chemically induced KW - Adenocarcinoma -- chemically induced KW - Mammary Neoplasms, Animal -- pathology KW - Recovery of Function KW - Mammary Neoplasms, Animal -- chemically induced KW - Neoplasms, Experimental -- pathology KW - Pregnancy KW - Adenocarcinoma -- pathology KW - Rats KW - Rats, Sprague-Dawley KW - Pituitary Neoplasms -- pathology KW - Adenoma -- chemically induced KW - Withholding Treatment KW - Adenoma -- pathology KW - Female KW - Male KW - Phytoestrogens -- toxicity KW - Reproduction -- drug effects KW - Neoplasms, Experimental -- etiology KW - Toxicity Tests, Chronic KW - Carcinogens -- toxicity KW - Genistein -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236459805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=MULTIGENERATIONAL+REPRODUCTIVE+TOXICOLOGY%3A+STUDY+OF+GENISTEIN+%28CAS+NO.+446-72-0%29+IN+SPRAGUE-DAWLEY+RATS+%28FEED+STUDY%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-03-01&rft.volume=&rft.issue=539&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2008 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 236441006 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236441006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2008-03-01&rft.volume=&rft.issue=539&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2008 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Highly Variable Drugs: Observations from Bioequivalence Data Submitted to the FDA for New Generic Drug Applications AN - 21262969; 11178374 JF - AAPS Journal AU - Davit, Barbara M AU - Conner, Dale P AU - Fabian-Fritsch, Beth AU - Haidar, Sam H AU - Jiang, Xiaojian AU - Patel, Devvrat T AU - Seo, Paul R H AU - Suh, Keri AU - Thompson, Christina L AU - Yu, Lawrence X AD - U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Generic Drugs, 7520 Standish Place, Rockville, Maryland 20855, USA, barbara.davit@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 148 EP - 156 PB - American Association of Pharmaceutical Scientists VL - 10 IS - 1 SN - 1550-7416, 1550-7416 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Drugs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21262969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=Highly+Variable+Drugs%3A+Observations+from+Bioequivalence+Data+Submitted+to+the+FDA+for+New+Generic+Drug+Applications&rft.au=Davit%2C+Barbara+M%3BConner%2C+Dale+P%3BFabian-Fritsch%2C+Beth%3BHaidar%2C+Sam+H%3BJiang%2C+Xiaojian%3BPatel%2C+Devvrat+T%3BSeo%2C+Paul+R+H%3BSuh%2C+Keri%3BThompson%2C+Christina+L%3BYu%2C+Lawrence+X&rft.aulast=Davit&rft.aufirst=Barbara&rft.date=2008-03-01&rft.volume=10&rft.issue=1&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Fs12248-008-9015-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Data processing; Drugs DO - http://dx.doi.org/10.1208/s12248-008-9015-x ER - TY - JOUR T1 - Pharmacogenetic and Metabolic Differences Between Dog Breeds: Their Impact on Canine Medicine and the Use of the Dog as a Preclinical Animal Model AN - 21217667; 11178370 AB - There is limited information describing species related pharmacogenetic differences in animals. Despite the lack of genetic information in veterinary medicine, breed specific responses to endogenous and exogenous substances have been reported across many species. This finding underscores the importance of obtaining insight into the genotypic and phenotypic variation present across breeds. This article provides a summary of the literature pertaining to canine breed differences in physiology, drug response, drug pharmacokinetics, and metabolic idiosyncrasies. The existing knowledge of pedigrees and the known phenotypes and genotypes of dogs provides important information for determining mode of inheritance, penetration, and other major characteristics of heritable traits. Understanding these breed differences will improve canine population predictions (for canine drug products) and may be of value when extrapolating toxicology data from dogs to humans. JF - AAPS Journal AU - Fleischer, Steven AU - Sharkey, Michele AU - Mealey, Katrina AU - Ostrander, Elaine A AU - Martinez, Marilyn AD - Center for Veterinary Medicine, The Food and Drug Administration, 7500 Standish Place, HFV-130, Rockville, Massachusetts 20855, USA, marilyn.martinez@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 110 EP - 119 PB - American Association of Pharmaceutical Scientists VL - 10 IS - 1 SN - 1550-7416, 1550-7416 KW - Toxicology Abstracts; Genetics Abstracts KW - Veterinary medicine KW - Data processing KW - Heredity KW - Animal models KW - Genotypes KW - Drugs KW - Pharmacogenetics KW - Pharmacokinetics KW - G 07870:Mammals KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21217667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=Pharmacogenetic+and+Metabolic+Differences+Between+Dog+Breeds%3A+Their+Impact+on+Canine+Medicine+and+the+Use+of+the+Dog+as+a+Preclinical+Animal+Model&rft.au=Fleischer%2C+Steven%3BSharkey%2C+Michele%3BMealey%2C+Katrina%3BOstrander%2C+Elaine+A%3BMartinez%2C+Marilyn&rft.aulast=Fleischer&rft.aufirst=Steven&rft.date=2008-03-01&rft.volume=10&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Fs12248-008-9011-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Veterinary medicine; Data processing; Heredity; Animal models; Genotypes; Drugs; Pharmacokinetics; Pharmacogenetics DO - http://dx.doi.org/10.1208/s12248-008-9011-1 ER - TY - JOUR T1 - Systematic and Simultaneous Gene Profiling of 84 Drug-Metabolizing Genes in Primary Human Hepatocytes AN - 21201968; 11621735 AB - Drug-metabolizing enzymes are an important battery of proteins that are involved in drug metabolism, xenobiotic detoxification, and drug-induced toxicity. Systematic, efficient, and simultaneous evaluation of drug-metabolizing gene expression in response to chemicals has a wide variety of implications in drug development, disease prevention, and personalized medicine and nutrition. In the current study, the authors have systematically and simultaneously evaluated the hepatic expression profile of drug-metabolizing enzymes in cultured human hepatocytes exposed to the xenobiotics rifampicin, omeprazole, and 3-methylcholanthrene (3-MC) using the Drug Metabolism RT super(2)Profiler+ PCR Arrays. This new high-throughput tool allowed the authors to evaluate the expression of genes coding for 84 drug-metabolizing enzymes (including phase 1 and phase 2 drug-metabolizing enzymes and transporters) simultaneously, in a 96-well format using a small amount of experimental materials. To validate the quality of the Drug Metabolism RT super(2)Profiler+ PCR Arrays, the PCR Array was compared with the well-documented platform TaqMan assay, and a high concordance was shown between these 2 methods, indicating the high reliability of the Drug Metabolism RT super(2)Profiler+ PCR Arrays. In addition, increasing or decreasing the expression of drug-metabolizing enzymes by these 3 compounds was observed, and underlying mechanisms are discussed. (Journal of Biomolecular Screening 2008; 194-201) JF - Journal of Biomolecular Screening AU - Ning, Baitang AU - Dial, Stacey AU - Sun, Yanyang AU - Wang, Jie AU - Yang, Jingping AU - Guo, Lei AD - Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 194 EP - 201 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 13 IS - 3 SN - 1087-0571, 1087-0571 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - real time-PCR KW - gene expression KW - drug-metabolizing enzyme KW - drug-metabolizing gene KW - Detoxification KW - Hepatocytes KW - Drug metabolism KW - 3-Methylcholanthrene KW - Omeprazole KW - Enzymes KW - Drug development KW - Toxicity KW - Nutrition KW - Gene expression KW - Rifampin KW - Liver KW - Polymerase chain reaction KW - G 07730:Development & Cell Cycle KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21201968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Systematic+and+Simultaneous+Gene+Profiling+of+84+Drug-Metabolizing+Genes+in+Primary+Human+Hepatocytes&rft.au=Ning%2C+Baitang%3BDial%2C+Stacey%3BSun%2C+Yanyang%3BWang%2C+Jie%3BYang%2C+Jingping%3BGuo%2C+Lei&rft.aulast=Ning&rft.aufirst=Baitang&rft.date=2008-03-01&rft.volume=13&rft.issue=3&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057108315513 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Detoxification; Hepatocytes; Drug metabolism; 3-Methylcholanthrene; Enzymes; Omeprazole; Drug development; Toxicity; Nutrition; Gene expression; Rifampin; Liver; Polymerase chain reaction DO - http://dx.doi.org/10.1177/1087057108315513 ER - TY - JOUR T1 - Comparative Evaluation of Flow for Pharmaceutical Powders and Granules AN - 21123105; 11176751 AB - The objective of the present work was to carry out a systematic evaluation of flow of pharmaceutical powders and granules using compendial and non-compendial methods. Angle of repose, bulk density, tapped density, Carr's compressibility index, and Hausner ratios were evaluated. Additionally, flow was characterized using a powder rheometer in which a sensitive force transducer monitors the forces generated as a result of the sample displacement. The critical attributes such as cohesivity index, caking strength, and flow stability were determined for samples. The samples consisted of different grades of magnesium stearate powder including bovine, vegetable, and food grade, physical mixture powder blend consisting of a model formulation, granules prepared by various methods including slugging, high shear granulator, and fluid bed dryer. Lubricant efficiency was also determined for granules lubricated with various concentrations of magnesium stearate. It was observed that the compendial methods were often non-discriminating for minor variations in powder flow. The additional characterization such as cohesivity, and caking strength were helpful in understanding the flow characteristics of pharmaceutical systems. The flow stability test determined that the powders were not affected by the test conditions on the rheometer. The non-compendial tests were discriminating to even minor variations in powder flow. JF - AAPS PharmSciTech AU - Shah, Rakhi B AU - Tawakkul, Mobin A AU - Khan, Mansoor A AD - Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA, Mansoor.khan@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 250 EP - 258 PB - Springer New York LLC VL - 9 IS - 1 SN - 1530-9932, 1530-9932 KW - Biotechnology and Bioengineering Abstracts KW - Granules KW - Powder KW - Vegetables KW - Lubricants KW - Food KW - Pharmaceuticals KW - Compressibility KW - Magnesium KW - Models KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21123105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+PharmSciTech&rft.atitle=Comparative+Evaluation+of+Flow+for+Pharmaceutical+Powders+and+Granules&rft.au=Shah%2C+Rakhi+B%3BTawakkul%2C+Mobin+A%3BKhan%2C+Mansoor+A&rft.aulast=Shah&rft.aufirst=Rakhi&rft.date=2008-03-01&rft.volume=9&rft.issue=1&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=AAPS+PharmSciTech&rft.issn=15309932&rft_id=info:doi/10.1208%2Fs12249-008-9046-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Granules; Powder; Vegetables; Food; Lubricants; Compressibility; Pharmaceuticals; Magnesium; Models DO - http://dx.doi.org/10.1208/s12249-008-9046-8 ER - TY - JOUR T1 - Assessment of Clostridium difficile-Associated Disease Surveillance Definitions, North Carolina, 2005 AN - 21042633; 8585039 AB - Objective. To determine the timing of community-onset Clostridium difficile-associated disease (CDAD) relative to the patient's last healthcare facility discharge, the association of postdischarge cases with healthcare facility-onset cases, and the influence of postdischarge cases on overall rates and interhospital comparison of rates of CDAD. Design. Retrospective cohort study for the period January 1, 2005, through December 31, 2005. Setting. Catchment areas of 6 acute care hospitals in North Carolina. Methods. We reviewed medical and laboratory records to determine the date of symptom onset, the dates of hospitalization, and stool C. difficile toxin assay results for patients with CDAD who had diarrhea and positive toxin-assay results. Cases were classified as healthcare facility- onset if they were diagnosed more than 48 hours after admission. Cases were defined as community-onset if they were diagnosed in the community or within 48 hours after admission, and were also classified on the basis of the time since the last discharge: if within 4 weeks, community-onset, healthcare facility-associated (CO-HCFA); if 4-12 weeks, indeterminate exposure; and if more than 12 weeks, community-associated. Pearson's correlation coefficient was used to assess the association between monthly rates of healthcare facility-onset, healthcare facility-associated (HO-HCFA) cases and CO-HCFA cases. We performed interhospital rate comparisons using HO-HCFA cases only and using both HO-HCFA and CO-HCFA cases. Results. Of 1046 CDAD cases, 442 (42%) were HO-HCFA cases and 604 (58%) were community-onset cases. Of the 604 community-onset cases, 94 (15%) were CO-HCFA, 40 (7%) were of indeterminate exposure, and 208 (34%) community-associated. A modest correlation was found between monthly rates of HO-HCFA cases and CO-HCFA cases across the 6 hospitals . Interhospital rankings changed for 6 of 11 months if CO-HCFA cases were included. Conclusions. A substantial proportion of community-onset cases of CDAD occur less than 4 weeks after discharge from a healthcare facility, and inclusion of CO-HCFA cases influences interhospital comparisons. Our findings support the use of a proposed definition of healthcare facility-associated CDAD that includes cases that occur within 4 weeks after discharge. JF - Infection Control and Hospital Epidemiology AU - Kutty, Preeta K AU - Benoit, Stephen R AU - Woods, Christopher W AU - Sena, Arlene C AU - Naggie, Susanna AU - Frederick, Joyce AU - Engemann, John AU - Evans, Sharon AU - Pien, Brian C AU - Banerjee, Shailendra N AU - Engel, Jeffery AU - McDonald, LClifford AD - Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, and the Epidemic Intelligence Service, Division of Applied Public Health Training, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, Georgia, CMcDonald1@cdc.gov. Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 197 EP - 202 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 29 IS - 3 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Clostridium KW - Diarrhea KW - Catchment areas KW - Feces KW - Toxins KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21042633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Assessment+of+Clostridium+difficile-Associated+Disease+Surveillance+Definitions%2C+North+Carolina%2C+2005&rft.au=Kutty%2C+Preeta+K%3BBenoit%2C+Stephen+R%3BWoods%2C+Christopher+W%3BSena%2C+Arlene+C%3BNaggie%2C+Susanna%3BFrederick%2C+Joyce%3BEngemann%2C+John%3BEvans%2C+Sharon%3BPien%2C+Brian+C%3BBanerjee%2C+Shailendra+N%3BEngel%2C+Jeffery%3BMcDonald%2C+LClifford&rft.aulast=Kutty&rft.aufirst=Preeta&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F528813 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diarrhea; Catchment areas; Feces; Toxins; Hospitals; Clostridium DO - http://dx.doi.org/10.1086/528813 ER - TY - JOUR T1 - Intracellular Organic Osmolytes: Function and Regulation AN - 20892389; 8086720 AB - Cells of almost all organisms accumulate organic osmolytes when exposed to hyperosmolality, most often in the form of high salt or urea. In this review, we discuss 1) how the organic osmolytes protect; 2) the identity of osmolytes in Archaea, bacteria, yeast, plants, marine animals, and mammals; 3) the mechanisms by which they are accumulated; 4) sensors of osmolality; 5) the signaling pathways involved; and 6) mutual counteraction by urea and methylamines. JF - Journal of Biological Chemistry AU - Burg, Maurice B AU - Ferraris, Joan D AD - Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1603 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 7309 EP - 7313 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 12 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Salts KW - Archaea KW - Plant protection KW - Reviews KW - Methylamine KW - Urea KW - Osmotic pressure KW - Signal transduction KW - J 02320:Cell Biology KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20892389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Intracellular+Organic+Osmolytes%3A+Function+and+Regulation&rft.au=Burg%2C+Maurice+B%3BFerraris%2C+Joan+D&rft.aulast=Burg&rft.aufirst=Maurice&rft.date=2008-03-01&rft.volume=283&rft.issue=12&rft.spage=7309&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Salts; Plant protection; Reviews; Methylamine; Urea; Osmotic pressure; Signal transduction; Archaea ER - TY - JOUR T1 - Diploposthe laevis (Bloch) Jacobi (Eucestoda, Hymenolepididae) from Netta peposaca (Vieillot) (Aves: Anatidae): first record for the Neotropical Region and a new host AN - 20889782; 8236600 AB - One hundred eight rosy-billed pochards, Netta peposaca (Vieillot, 1816), collected in Brazil and Argentina were examined for endoparasites. Collection sites included the municipalities of Santa Vitoria do Palmar and Jaguarao, Rio Grande do Sul State, Brazil (wintering site) and Alvear, Corrientes Province, northern Argentina (nesting site). Birds were frozen in dry ice after collection. During necropsy they were categorized according to sex and maturation, either adult or juvenile. The cestode Diploposthe laevis (Bloch) Jacobi, 1896 was found (prevalence 68.5%, mean infection was 2). The mean prevalence of D. laevis in Alvear (25.9%) was higher than found in Jaguarao and Santa Vitoria do Palmar, Rio Grande do Sul (19%), and could be related to the nesting site and to the period when the birds may ingest a higher amount of food. This is the first record of a species of the genus Diploposthe in anatideans from South America, and the first record of the species in N. peposaca. Details of the cirrus pouch and vagina were described based on histological sections. JF - Revista Brasileira de Zoologia AU - Silveira, Eliane FDa AU - Amato, Suzana B Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 83 EP - 88 PB - Sociedade Brasileira de Zoologia, Caixa Postal 19020 Curitiba Parana 81531-990 Brazil, [mailto:sbz@bio.ufpr.br] VL - 25 IS - 1 SN - 0101-8175, 0101-8175 KW - Ecology Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Argentina KW - Brazil KW - migratory flyway KW - nesting site KW - rosy-billed pochard KW - wintering site * KW - New records KW - Autopsy KW - Neotropical Region KW - Eucestoda KW - Overwintering KW - Brazil, Rio Grande do Sul KW - Food KW - Anatidae KW - Infection KW - Endoparasites KW - Aves KW - Nesting KW - Sexual maturity KW - Vagina KW - Netta peposaca KW - Argentina, Corrientes KW - Reproductive behaviour KW - Hymenolepididae KW - Cestoda KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08442:Population dynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20889782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Revista+Brasileira+de+Zoologia&rft.atitle=Diploposthe+laevis+%28Bloch%29+Jacobi+%28Eucestoda%2C+Hymenolepididae%29+from+Netta+peposaca+%28Vieillot%29+%28Aves%3A+Anatidae%29%3A+first+record+for+the+Neotropical+Region+and+a+new+host&rft.au=Silveira%2C+Eliane+FDa%3BAmato%2C+Suzana+B&rft.aulast=Silveira&rft.aufirst=Eliane&rft.date=2008-03-01&rft.volume=25&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Revista+Brasileira+de+Zoologia&rft.issn=01018175&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - New records; Overwintering; Sexual maturity; Nesting; Reproductive behaviour; Endoparasites; Autopsy; Food; Vagina; Infection; Aves; Eucestoda; Anatidae; Netta peposaca; Hymenolepididae; Cestoda; Neotropical Region; Argentina; Brazil, Rio Grande do Sul; Argentina, Corrientes ER - TY - JOUR T1 - Altered Utilization of N-Acetyl-D-Galactosamine by Escherichia coli O157:H7 from the 2006 Spinach Outbreak AN - 20860647; 8038197 AB - In silico analyses of previously sequenced strains of Escherichia coli O157:H7, EDL933 and Sakai, localized the gene cluster for the utilization of N-acetyl-D-galactosamine (Aga) and D-galactosamine (Gam). This gene cluster encodes the Aga phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) and other catabolic enzymes responsible for transport and catabolism of Aga. As the complete coding sequences for enzyme IIA (EIIA) super(Aga/Gam), EIIB super(Aga), EIIC super(Aga), and EIID super(Aga) of the Aga PTS are present, E. coli O157:H7 strains normally are able to utilize Aga as a sole carbon source. The Gam PTS complex, in contrast, lacks EIIC super(Gam), and consequently, E. coli O157:H7 strains cannot utilize Gam. Phenotypic analyses of 120 independent isolates of E. coli O157:H7 from our culture collection revealed that the overwhelming majority (118/120) displayed the expected Aga super(+) Gam super(-) phenotype. Yet, when 194 individual isolates, derived from a 2006 spinach-associated E. coli O157:H7 outbreak, were analyzed, all (194/194) displayed an Aga super(-) Gam super(-) phenotype. Comparison of aga/gam sequences from two spinach isolates with those of EDL933 and Sakai revealed a single nucleotide change (G:C arrow right A:T) in the agaF gene in the spinach-associated isolates. The base substitution in agaF, which encodes EIIA super(Aga/Gam) of the PTS, changes a conserved glycine residue to serine (Gly91Ser). Pyrosequencing of this region showed that all spinach-associated E. coli O157:H7 isolates harbored this same G:C arrow right A:T substitution. Notably, when agaF super(+) was cloned into an expression vector and transformed into six spinach isolates, all (6/6) were able to grow on Aga, thus demonstrating that the Gly91Ser substitution underlies the Aga super(-) phenotype in these isolates. JF - Journal of Bacteriology AU - Mukherjee, Amit AU - Mammel, Mark K AU - LeClerc, JEugene AU - Cebula, Thomas A AD - Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 1710 EP - 1717 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 5 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Glycine KW - Enzymes KW - phosphotransferase KW - Carbon sources KW - D-Galactosamine KW - Expression vectors KW - Gene clusters KW - Escherichia coli KW - Culture collections KW - Spinacia oleracea KW - N-Acetyl-D-galactosamine KW - Serine KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Altered+Utilization+of+N-Acetyl-D-Galactosamine+by+Escherichia+coli+O157%3AH7+from+the+2006+Spinach+Outbreak&rft.au=Mukherjee%2C+Amit%3BMammel%2C+Mark+K%3BLeClerc%2C+JEugene%3BCebula%2C+Thomas+A&rft.aulast=Mukherjee&rft.aufirst=Amit&rft.date=2008-03-01&rft.volume=190&rft.issue=5&rft.spage=1710&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Expression vectors; Glycine; Gene clusters; Culture collections; Enzymes; Carbon sources; phosphotransferase; D-Galactosamine; N-Acetyl-D-galactosamine; Serine; Escherichia coli; Spinacia oleracea ER - TY - JOUR T1 - Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice AN - 20809303; 8085035 AB - Many studies using mammalian cellular and subcellular systems have demonstrated that polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), are metabolically activated by cytochrome P450s (CYPs). In order to evaluate the role of hepatic versus extra-hepatic metabolism of BaP and its pharmacokinetics, we used the hepatic cytochrome P450 reductase null (HRN) mouse model, in which cytochrome P450 oxidoreductase, the unique electron donor to CYPs, is deleted specifically in hepatocytes, resulting in the loss of essentially all hepatic CYP function. HRN and wild-type (WT) mice were treated intraperitoneally (i.p.) with 125 mg/kg body wt BaP daily for up to 5 days. Clearance of BaP from blood was analysed by high-performance liquid chromatography with fluorescence detection. DNA adduct levels were measured by super(32)P-post-labelling analysis with structural confirmation of the formation of 10-(deoxyguanosin-N super(2)-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobe nzo[a]pyrene by liquid chromatography-tandem mass spectrometry analysis. Hepatic microsomes isolated from BaP-treated and untreated mice were also incubated with BaP and DNA in vitro. BaP-DNA adduct formation was up to 7-fold lower with the microsomes from HRN mice than with that from WT mice. Most of the hepatic microsomal activation of BaP in vitro was attributable to CYP1A. Pharmacokinetic analysis of BaP in blood revealed no significant differences between HRN and WT mice. BaP-DNA adduct levels were higher in the livers (up to 13-fold) and elevated in several extra-hepatic tissues of HRN mice (by 1.7- to 2.6-fold) relative to WT mice. These data reveal an apparent paradox, whereby hepatic CYP enzymes appear to be more important for detoxification of BaP in vivo, despite being involved in its metabolic activation in vitro. JF - Carcinogenesis AU - Arlt, Volker M AU - Stiborova, Marie AU - Henderson, Colin J AU - Thiemann, Markus AU - Frei, Eva AU - Aimova, Dagmar AU - Singh, Rajinder AU - Gamboa da Costa, Goncalo AU - Schmitz, Oliver J AU - Farmer, Peter B AU - Wolf, CRoland AU - Phillips, David H AD - Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK. Department of Biochemistry, Faculty of Science, Charles University, 128 40 Prague 2, Czech Republic. Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Dundee DD1 9SY, UK. Department of Analytical Chemistry, University of Wuppertal, D-42119 Wuppertal, Germany. Division of Molecular Toxicology, German Cancer Research Center, D-69126 Heidelberg, Germany. Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, Leicester LE1 7RH, UK. Present address: Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 656 EP - 665 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 29 IS - 3 SN - 0143-3334, 0143-3334 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Detoxification KW - High-performance liquid chromatography KW - DNA adducts KW - Microsomes KW - Polycyclic aromatic hydrocarbons KW - Fluorescence KW - Data processing KW - Hepatocytes KW - Animal models KW - Enzymes KW - Pharmacokinetics KW - Mass spectroscopy KW - Blood KW - NADPH-ferrihemoprotein reductase KW - reductase KW - Carcinogenesis KW - Liver KW - Metabolic activation KW - oxidoreductase KW - Benzo(a)pyrene KW - Cytochrome P450 KW - N 14820:DNA Metabolism & Structure KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20809303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Metabolic+activation+of+benzo%5Ba%5Dpyrene+in+vitro+by+hepatic+cytochrome+P450+contrasts+with+detoxification+in+vivo%3A+experiments+with+hepatic+cytochrome+P450+reductase+null+mice&rft.au=Arlt%2C+Volker+M%3BStiborova%2C+Marie%3BHenderson%2C+Colin+J%3BThiemann%2C+Markus%3BFrei%2C+Eva%3BAimova%2C+Dagmar%3BSingh%2C+Rajinder%3BGamboa+da+Costa%2C+Goncalo%3BSchmitz%2C+Oliver+J%3BFarmer%2C+Peter+B%3BWolf%2C+CRoland%3BPhillips%2C+David+H&rft.aulast=Arlt&rft.aufirst=Volker&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Detoxification; DNA adducts; Polycyclic aromatic hydrocarbons; Microsomes; Data processing; Fluorescence; Hepatocytes; Animal models; Enzymes; Mass spectroscopy; Pharmacokinetics; Blood; NADPH-ferrihemoprotein reductase; reductase; Carcinogenesis; Liver; oxidoreductase; Metabolic activation; Benzo(a)pyrene; Cytochrome P450 ER - TY - JOUR T1 - Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene AN - 20808691; 8085033 AB - Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify the role of carcinogens in both the genetic and epigenetic changes in premalignant tissues and a lack of conclusive information on the link between epigenetic alterations and carcinogenic exposure. In the current study, we investigated whether or not the mechanism of 2-AAF-induced hepatocarcinogenesis consists of both genotoxic (genetic) and non-genotoxic (epigenetic) alterations. Male and female Sprague-Dawley rats were fed NIH-31 diet containing 0.02% of 2-AAF for 6, 12, 18 or 24 weeks. The levels of DNA adducts obtained from 2-AAF in liver and kidney tissues were assessed by high-performance liquid chromatography combined with electrospray tandem mass spectrometry (HPLC-ES-MS/MS). N-(Deoxyguanosine-8-yl)-2-aminofluorene was the major adduct detected at all time points in both tissues. Global DNA methylation in the livers and kidneys, as determined by an HpaII-based cytosine extension assay and by HPLC-ES-MS/MS, did not change over the 24-week period. In the livers of male rats, there was a progressive decrease of global and long interspersed nucleotide element-1-associated histone H4 lysine 20 trimethylation, as well as hypermethylation of the p16 super(INK4A) gene. These epigenetic changes were not observed in the livers of female rats or the kidneys of both sexes. Importantly, morphological evidence of formation and progression of neoplastic process was observed in the liver of male rats only. In conclusion, we have demonstrated that exposure of rats to genotoxic hepatocarcinogen 2-AAF, in addition to formation of 2-AAF-specific DNA lesions, resulted in substantial alterations in cellular epigenetic status. JF - Carcinogenesis AU - Bagnyukova, Tetyana V AU - Tryndyak, Volodymyr P AU - Montgomery, Beverly AU - Churchwell, Mona I AU - Karpf, Adam R AU - James, Smitha R AU - Muskhelishvili, Levan AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 72079, USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 638 EP - 646 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 29 IS - 3 SN - 0143-3334, 0143-3334 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts; Genetics Abstracts KW - Diets KW - High-performance liquid chromatography KW - DNA adducts KW - INK4a protein KW - Genotoxicity KW - Tumorigenesis KW - Lysine KW - Carcinogens KW - Mass spectroscopy KW - Nucleotides KW - Cytosine KW - Histone H4 KW - p16 protein KW - epigenetics KW - Carcinogenesis KW - DNA methylation KW - Kidney KW - Liver KW - Methylation KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20808691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Genetic+and+epigenetic+changes+in+rat+preneoplastic+liver+tissue+induced+by+2-acetylaminofluorene&rft.au=Bagnyukova%2C+Tetyana+V%3BTryndyak%2C+Volodymyr+P%3BMontgomery%2C+Beverly%3BChurchwell%2C+Mona+I%3BKarpf%2C+Adam+R%3BJames%2C+Smitha+R%3BMuskhelishvili%2C+Levan%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Bagnyukova&rft.aufirst=Tetyana&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Diets; DNA adducts; INK4a protein; Tumorigenesis; Genotoxicity; Lysine; Carcinogens; Nucleotides; Mass spectroscopy; Cytosine; p16 protein; Histone H4; epigenetics; Carcinogenesis; Liver; Kidney; DNA methylation; Methylation ER - TY - JOUR T1 - Effects of Liver X Receptor Agonist Treatment on Pulmonary Inflammation and Host Defense AN - 20771814; 8039745 AB - Liver X receptor (LXR) alpha and beta are members of the nuclear receptor superfamily of ligand-activated transcription factors. Best known for triggering "reverse cholesterol transport" gene programs upon their activation by endogenous oxysterols, LXRs have recently also been implicated in regulation of innate immunity. In this study, we define a role for LXRs in regulation of pulmonary inflammation and host defense and identify the lung and neutrophil as novel in vivo targets for pharmacologic LXR activation. LXR is expressed in murine alveolar macrophages, alveolar epithelial type II cells, and neutrophils. Treatment of mice with TO-901317, a synthetic LXR agonist, reduces influx of neutrophils to the lung triggered by inhaled LPS, intratracheal KC chemokine, and intratracheal Klebsiella pneumoniae and impairs pulmonary host defense against this bacterium. Pharmacologic LXR activation selectively modulates airspace cytokine expression induced by both LPS and K. pneumoniae. Moreover, we report for the first time that LXR activation impairs neutrophil motility and identify inhibition of chemokine-induced RhoA activation as a putative underlying mechanism. Taken together, these data define a novel role for LXR in lung pathophysiology and neutrophil biology and identify pharmacologic activation of LXR as a potential tool for modulation of innate immunity in the lung. JF - Journal of Immunology AU - Smoak, Kathleen AU - Madenspacher, Jennifer AU - Jeyaseelan, Samithamby AU - Williams, Belinda AU - Dixon, Darlene AU - Poch, Katie R AU - Nick, Jerry A AU - Worthen, GScott AU - Fessler, Michael B AD - Laboratory of Respiratory Biology and Department of Health and Human Services, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709. Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206 Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 3305 EP - 3312 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 5 SN - 0022-1767, 0022-1767 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Chemokines KW - Nuclear receptors KW - Leukocytes (neutrophilic) KW - Immunity KW - Cholesterol KW - Alveoli KW - Inflammation KW - Cell activation KW - RhoA protein KW - Motility KW - liver X receptors KW - Lung KW - Transcription factors KW - Cytokines KW - Lipopolysaccharides KW - Trachea KW - Klebsiella pneumoniae KW - N 14835:Protein-Nucleic Acids Association KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20771814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Effects+of+Liver+X+Receptor+Agonist+Treatment+on+Pulmonary+Inflammation+and+Host+Defense&rft.au=Smoak%2C+Kathleen%3BMadenspacher%2C+Jennifer%3BJeyaseelan%2C+Samithamby%3BWilliams%2C+Belinda%3BDixon%2C+Darlene%3BPoch%2C+Katie+R%3BNick%2C+Jerry+A%3BWorthen%2C+GScott%3BFessler%2C+Michael+B&rft.aulast=Smoak&rft.aufirst=Kathleen&rft.date=2008-03-01&rft.volume=180&rft.issue=5&rft.spage=3305&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Chemokines; Nuclear receptors; Leukocytes (neutrophilic); Cholesterol; Immunity; Alveoli; RhoA protein; Cell activation; Inflammation; Motility; Lung; liver X receptors; Transcription factors; Lipopolysaccharides; Cytokines; Trachea; Klebsiella pneumoniae ER - TY - JOUR T1 - Clarification of FDA and The Joint Commission reporting requirements for US tissue recipient adverse reactions AN - 20768684; 8155670 JF - Cell and Tissue Banking AU - Khoie, Tina AU - Zinderman, Craig E AU - Solomon, Ruth AU - Wise, Robert P AU - Lee, Karen C AU - Nether, Klaus AD - Center for Biologics Evaluation and Research, Rockville, MD, USA, tina.khoie@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 67 EP - 68 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 9 IS - 1 SN - 1389-9333, 1389-9333 KW - Federal drug administration KW - Biotechnology and Bioengineering Abstracts KW - Tissues KW - Transplantation KW - Side effects KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20768684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+and+Tissue+Banking&rft.atitle=Clarification+of+FDA+and+The+Joint+Commission+reporting+requirements+for+US+tissue+recipient+adverse+reactions&rft.au=Khoie%2C+Tina%3BZinderman%2C+Craig+E%3BSolomon%2C+Ruth%3BWise%2C+Robert+P%3BLee%2C+Karen+C%3BNether%2C+Klaus&rft.aulast=Khoie&rft.aufirst=Tina&rft.date=2008-03-01&rft.volume=9&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Cell+and+Tissue+Banking&rft.issn=13899333&rft_id=info:doi/10.1007%2Fs10561-007-9043-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tissues; Transplantation; Side effects DO - http://dx.doi.org/10.1007/s10561-007-9043-2 ER - TY - JOUR T1 - Adiposity, Physical Activity, and Pancreatic Cancer in the National Institutes of Health-AARP Diet and Health Cohort AN - 20762472; 8083992 AB - Obesity and lack of physical activity have been inconsistently associated with pancreatic cancer. Using data from a self-administered baseline questionnaire (1995-1996), the authors investigated the association between adiposity and physical activity and pancreatic cancer in 495,035 participants of the National Institutes of Health-AARP Diet and Health Study who were aged 50-71 years. To avoid the influence of subclinical disease, follow-up time started 1 year after baseline, and subjects with a body mass index (BMI) of <18.5 kg/m@@u2@ were excluded. A subcohort (n = 302,060) completed a second questionnaire with information about physical activity and waist and hip circumference. During follow-up though 2000, 654 pancreatic cancer cases were identified. The authors used Cox proportional hazard models to generate adjusted hazard ratios and 95% confidence intervals. Compared with those with a BMI of 18.5-<25, those with a BMI of ^.35 had a 45% greater pancreatic cancer risk (95% confidence interval (CI): 1.04, 2.02; p@@dtrend@ = 0.02). Significant positive associations for BMI were observed among nonsmokers (for BMI ^.35: hazard ratio = 1.70, 95% CI: 1.14, 2.53; p@@dtrend@ = 0.004) but not recent smokers (p@@dinteraction@ = 0.08). Waist circumference was positively associated with pancreatic cancer (fourth vs. first quartile: hazard ratio = 2.53, 95% CI: 1.13, 5.65; p@@dtrend@ = 0.04) in women but not men. The authors observed no association with physical activity. Their results suggest a positive association between adiposity and pancreatic cancer. JF - American Journal of Epidemiology AU - Stolzenberg-Solomon, Rachael Z AU - Adams, Kenneth AU - Leitzmann, Michael AU - Schairer, Catherine AU - Michaud, Dominique S AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Silverman, Debra T AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 586 EP - 597 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 167 IS - 5 SN - 0002-9262, 0002-9262 KW - Physical Education Index KW - Waist KW - Body mass KW - Surveys KW - Health KW - Diet KW - Exercise KW - Hips KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20762472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Adiposity%2C+Physical+Activity%2C+and+Pancreatic+Cancer+in+the+National+Institutes+of+Health-AARP+Diet+and+Health+Cohort&rft.au=Stolzenberg-Solomon%2C+Rachael+Z%3BAdams%2C+Kenneth%3BLeitzmann%2C+Michael%3BSchairer%2C+Catherine%3BMichaud%2C+Dominique+S%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BSilverman%2C+Debra+T&rft.aulast=Stolzenberg-Solomon&rft.aufirst=Rachael&rft.date=2008-03-01&rft.volume=167&rft.issue=5&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Body mass; Exercise; Health; Waist; Diet; Surveys; Hips ER - TY - JOUR T1 - Flavonoid Intake and Risk of Pancreatic Cancer in Male Smokers (Finland) AN - 20729280; 8085076 AB - Extending research on the protective effect of flavonoids in cell culture and animal studies, we examined the association between consumption of flavonoids and flavonoid-rich foods and development of exocrine pancreatic cancer within the alpha -Tocopherol, beta -Carotene Cancer Prevention Study cohort. Of the 27,111 healthy male smokers (50-69 years) who completed a self-administered dietary questionnaire at baseline, 306 developed exocrine pancreatic cancer during follow-up (1985-2004; median, 16.1 years). Intakes of total flavonoids, three flavonoid subgroups, seven individual flavonoids, and flavonoid-rich foods were estimated from a validated food frequency questionnaire. Hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. Overall, flavonoid intake was not significantly associated with pancreatic cancer. However, in stratified analysis, greater total flavonoid intake was associated with decreased pancreatic cancer risk in participants randomized during the trial to placebo (fourth versus first quartile: hazard ratio, 0.36; 95% confidence interval, 0.17-0.78; P sub(trend) = 0.009) and not to supplemental alpha -tocopherol (50 mg/d) and/or beta -carotene (20 mg/d; P sub(interaction) = 0.002). Similar patterns and significant interactions were observed for flavonols, flavan-3-ols, kaempferol, quercetin, catechin, and epicatechin. Our data suggest that a flavonoid-rich diet may decrease pancreatic cancer risk in male smokers not consuming supplemental alpha -tocopherol and/or beta -carotene. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):553-62) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Bobe, Gerd AU - Weinstein, Stephanie J AU - Albanes, Demetrius AU - Hirvonen, Tero AU - Ashby, Jason AU - Taylor, Phil R AU - Virtamo, Jarmo AU - Stolzenberg-Solomon, Rachael Z AD - Nutritional Epidemiology Branch and Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 553 EP - 562 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - Diets KW - pancreatic cancer KW - Finland KW - prevention KW - males KW - Cancer KW - flavonoids KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Flavonoid+Intake+and+Risk+of+Pancreatic+Cancer+in+Male+Smokers+%28Finland%29&rft.au=Bobe%2C+Gerd%3BWeinstein%2C+Stephanie+J%3BAlbanes%2C+Demetrius%3BHirvonen%2C+Tero%3BAshby%2C+Jason%3BTaylor%2C+Phil+R%3BVirtamo%2C+Jarmo%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Bobe&rft.aufirst=Gerd&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Bioindicators; pancreatic cancer; prevention; males; Cancer; flavonoids; Finland ER - TY - JOUR T1 - Polymorphisms of Genes in the Lipid Metabolism Pathway and Risk of Biliary Tract Cancers and Stones: A Population-Based Case-Control Study in Shanghai, China AN - 20729161; 8085073 AB - Biliary tract cancers, encompassing the gallbladder, extrahepatic bile duct, and ampulla of Vater, are uncommon yet highly fatal malignancies. Gallstones, the primary risk factor for biliary cancers, are linked with hyperlipidemia. We examined the associations of 12 single nucleotide polymorphisms of five genes in the lipid metabolism pathway with the risks of biliary cancers and stones in a population-based case-control study in Shanghai, China. We included 235 gallbladder, 125 extrahepatic bile duct, and 46 ampulla of Vater cancer cases, 880 biliary stone cases, and 779 population controls. Subjects completed an in-person interview and gave blood. Genotyping was conducted by TaqMan assay using DNA from buffy coats. The effects of APOE IVS1+69 (rs440446) and APOB IVS6+360C>T (rs520354) markers were limited to men. Men carrying the G allele of APOE IVS1+69 had a 1.7-fold risk of stones [95% confidence interval (95% CI), 1.2-2.4], a 1.8-fold risk of gallbladder cancer (95% CI, 1.0-3.3), a 3.7-fold risk of bile duct cancer (95% CI, 2.0-7.0), and a 4-fold risk of ampullary cancer (95% CI, 1.4-12.4). Male carriers of the T allele of APOB IVS6+360C>T had a 2-fold risk of bile duct cancer (95% CI, 1.2-3.4). The APOB T-T haplotype (APOB IVS6+360C>T, EX4+56C>T) was associated with a 1.6-fold risk of bile duct cancer (95% CI, 1.1-2.3). Male and female carriers of the T allele of LDLR IVS9-30C>T (rs1003723) had a 1.5-fold risk of bile duct cancer. Our findings suggest that gene variants in the lipid metabolism pathway contribute to the risk of biliary tract stones and cancers, particularly of the bile duct. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):525-34) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Andreotti, Gabriella AU - Chen, Jinbo AU - Gao, Yu-Tang AU - Rashid, Asif AU - Chen, Bingshu E AU - Rosenberg, Philip AU - Sakoda, Lori C AU - Deng, Jie AU - Shen, Ming-Chang AU - Wang, Bing-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Yeager, Meredith AU - Welch, Robert AU - Chanock, Stephen AU - Fraumeni, Joseph FJr AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 525 EP - 534 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts KW - Lipids KW - Lipoprotein (low density) receptors KW - Gene polymorphism KW - Hyperlipidemia KW - Apolipoprotein E KW - Buffy coat KW - Malignancy KW - Haplotypes KW - Risk factors KW - prevention KW - Ampulla of Vater KW - population control KW - Bioindicators KW - Bile duct KW - Genotyping KW - haplotypes KW - biomarkers KW - Biliary tract KW - Cancer KW - Lipid metabolism KW - Gallbladder KW - Blood KW - Single-nucleotide polymorphism KW - DNA KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Metabolism KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Polymorphisms+of+Genes+in+the+Lipid+Metabolism+Pathway+and+Risk+of+Biliary+Tract+Cancers+and+Stones%3A+A+Population-Based+Case-Control+Study+in+Shanghai%2C+China&rft.au=Andreotti%2C+Gabriella%3BChen%2C+Jinbo%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip%3BSakoda%2C+Lori+C%3BDeng%2C+Jie%3BShen%2C+Ming-Chang%3BWang%2C+Bing-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BChanock%2C+Stephen%3BFraumeni%2C+Joseph+FJr%3BHsing%2C+Ann+W&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bile duct; Genotyping; Gene polymorphism; Lipoprotein (low density) receptors; Apolipoprotein E; Hyperlipidemia; Buffy coat; biomarkers; Cancer; Biliary tract; Lipid metabolism; Blood; Gallbladder; Malignancy; Haplotypes; Single-nucleotide polymorphism; Risk factors; DNA; Ampulla of Vater; Bioindicators; Lipids; prevention; haplotypes; population control; Metabolism; China, People's Rep., Shanghai; China, People's Rep. ER - TY - JOUR T1 - Dietary Fiber, Lung Function, and Chronic Obstructive Pulmonary Disease in the Atherosclerosis Risk in Communities Study AN - 20727499; 8083990 AB - Recent data suggest beneficial effects of fiber intake on chronic respiratory symptoms in adults that are independent of antioxidant vitamin intake, but little is known about fiber consumption in relation to lung function and chronic obstructive pulmonary disease (COPD). The authors investigated the association of fiber intake with lung function and COPD in 11,897 US men and women from the Atherosclerosis Risk in Communities study (1987-1989). After control for potential confounders, positive associations were found between lung function and fiber intake from all sources as well as from cereal or fruit alone. Compared with those in the lowest quintile, participants in the highest quintile of total fiber intake had a 60.2-ml higher forced expiratory volume in 1 second (FEV sub(1)) (p for trend < 0.001), 55.2-ml higher forced vital capacity (FVC) (p = 0.001), 0.4% higher FEV sub(1)/FVC ratio (p = 0.040), 1.8% higher percent predicted FEV sub(1) (p < 0.001), and 1.4% higher percent predicted FVC (p = 0.001). Adjusted odds ratios of COPD for the highest versus lowest quintiles of intake were 0.85 (p = 0.044) for total fiber, 0.83 (p = 0.021) for cereal fiber, and 0.72 (p = 0.005) for fruit fiber. This study provides the first known evidence that dietary fiber is independently associated with better lung function and reduced prevalence of COPD. JF - American Journal of Epidemiology AU - Kan, Haidong AU - Stevens, June AU - Heiss, Gerardo AU - Rose, Kathryn M AU - London, Stephanie J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 570 EP - 578 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 167 IS - 5 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Diets KW - Antioxidants KW - fruits KW - Fibers KW - vitamins KW - Respiratory function KW - chronic obstructive pulmonary disease KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Dietary+Fiber%2C+Lung+Function%2C+and+Chronic+Obstructive+Pulmonary+Disease+in+the+Atherosclerosis+Risk+in+Communities+Study&rft.au=Kan%2C+Haidong%3BStevens%2C+June%3BHeiss%2C+Gerardo%3BRose%2C+Kathryn+M%3BLondon%2C+Stephanie+J&rft.aulast=Kan&rft.aufirst=Haidong&rft.date=2008-03-01&rft.volume=167&rft.issue=5&rft.spage=570&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Fibers; Respiratory function; Diets; fruits; chronic obstructive pulmonary disease; vitamins; Antioxidants ER - TY - JOUR T1 - Risk of Testicular Germ Cell Tumors and Polymorphisms in the Insulin-Like Growth Factor Genes AN - 20726905; 8085099 AB - Because taller men are at increased risk of developing testicular germ cell tumors (TGCT), it is conceivable that factors that influence adult height could be related to risk of TGCT. Because common genetic variation in genes of the insulin-like growth factor (IGF) pathway could influence somatic growth, 43 single nucleotide polymorphisms in four IGF genes (IGF-1, IGF-1R, IGF-2, and IGFALS) were genotyped in 577 case and 707 control participants from the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study to assess relationships with TGCT risk; additionally, associations between polymorphisms and adult height were examined. Relationships between polymorphisms and adult height were assessed using adjusted linear regression models, and associations between polymorphisms and TGCT risk were determined by adjusted logistic regression models estimating odds ratios. Although four IGF-1R polymorphisms (rs907806, rs3743258, rs229765, and rs9282714) were associated with height (P sub(trend) < 0.05), there were no relationships with any other polymorphism. Overall, there were no associations among polymorphisms or haplotypes in the IGF genes and TGCT risk, with odds ratios ranging from 0.55 to 1.50. Similarly, there was no association among the polymorphisms and risk of specific TGCT histologies (seminoma and nonseminoma). There was a suggestion, however, that adult height may modify the relationship between an IGF-1 haplotype and TGCT risk. These results suggest that, in aggregate, genetic variation in IGF loci is not associated with TGCT risk. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):721-6) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Chia, Victoria M AU - Sakoda, Lori C AU - Graubard, Barry I AU - Rubertone, Mark V AU - Chanock, Stephen J AU - Erickson, Ralph L AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 721 EP - 726 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts; Oncogenes & Growth Factors Abstracts KW - Testes KW - Body height KW - Gene polymorphism KW - Bone growth KW - Genetic diversity KW - tumors KW - Haplotypes KW - prevention KW - Regression analysis KW - growth factors KW - Bioindicators KW - Insulin-like growth factor I KW - Germ cells KW - genetic diversity KW - haplotypes KW - Tumors KW - biomarkers KW - Cancer KW - USA KW - Histology KW - Single-nucleotide polymorphism KW - Insulin-like growth factors KW - seminoma KW - B 26600:Tyrosine Kinase Activity KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Risk+of+Testicular+Germ+Cell+Tumors+and+Polymorphisms+in+the+Insulin-Like+Growth+Factor+Genes&rft.au=Chia%2C+Victoria+M%3BSakoda%2C+Lori+C%3BGraubard%2C+Barry+I%3BRubertone%2C+Mark+V%3BChanock%2C+Stephen+J%3BErickson%2C+Ralph+L%3BMcGlynn%2C+Katherine+A&rft.aulast=Chia&rft.aufirst=Victoria&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Testes; Insulin-like growth factor I; Body height; Gene polymorphism; Bone growth; Germ cells; Genetic diversity; Tumors; biomarkers; Cancer; Haplotypes; Single-nucleotide polymorphism; Insulin-like growth factors; Regression analysis; seminoma; Bioindicators; Histology; prevention; genetic diversity; tumors; haplotypes; growth factors; USA ER - TY - JOUR T1 - Real-Time PCR Assays for Quantification and Differentiation of Vibrio vulnificus Strains in Oysters and Water AN - 20705235; 8083552 AB - Vibrio vulnificus is an autochthonous estuarine bacterium and a pathogen that is frequently transmitted via raw shellfish. Septicemia can occur within 24 h; however, isolation and confirmation from water and oysters require days. Real-time PCR assays were developed to detect and differentiate two 16S rRNA variants, types A and B, which were previously associated with environmental sources and clinical fatalities, respectively. Both assays could detect 10 super(2) to 10 super(3) V. vulnificus total cells in seeded estuarine water and in oyster homogenates. PCR assays on 11 reference V. vulnificus strains and 22 nontarget species gave expected results (type A or B for V. vulnificus and negative for nontarget species). The relationship between cell number and cycle threshold for the assays was linear (R super(2) = >0.93). The type A/B ratio of Florida clinical isolates was compared to that of isolates from oysters harvested in Florida waters. This ratio was 19:17 in clinical isolates and 5:8 (n = 26) in oysters harvested from restricted sites with poor water quality but was 10:1 (n = 22) in oysters from permitted sites with good water quality. A substantial percentage of isolates from oysters (19.4%) were type AB (both primer sets amplified), but no isolates from overlying waters were type AB. The real-time PCR assays were sensitive, specific, and quantitative in water samples and could also differentiate the strains in oysters without requiring isolation of V. vulnificus and may therefore be useful for rapid detection of the pathogen in shellfish and water, as well as further investigation of its population dynamics. JF - Applied and Environmental Microbiology AU - Gordon, Katrina V AU - Vickery, Michael C AU - DePaola, Angelo AU - Staley, Christopher AU - Harwood, Valerie J AD - Department of Biology, University of South Florida, Tampa, Florida 33620. BioGX, Inc., Birmingham, Alabama 35203. Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, Dauphin Island, Alabama 36528 Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 1704 EP - 1709 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 74 IS - 6 SN - 0099-2240, 0099-2240 KW - Pollution Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - water quality KW - Water sampling KW - Septicemia KW - Nucleotide sequence KW - Population dynamics KW - Water quality KW - Public health KW - Disease transmission KW - Differentiation KW - oysters KW - Vibrio vulnificus KW - Polymerase chain reaction KW - Clinical isolates KW - ASW, USA, Florida KW - Mortality KW - Cell number KW - Pathogenic bacteria KW - Estuaries KW - Brackish KW - Assays KW - Pathogens KW - Antibodies KW - DNA KW - Water wells KW - Marine molluscs KW - Shellfish KW - Primers KW - rRNA 16S KW - J 02410:Animal Diseases KW - P 2000:FRESHWATER POLLUTION KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08484:Species interactions: parasites and diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20705235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Real-Time+PCR+Assays+for+Quantification+and+Differentiation+of+Vibrio+vulnificus+Strains+in+Oysters+and+Water&rft.au=Gordon%2C+Katrina+V%3BVickery%2C+Michael+C%3BDePaola%2C+Angelo%3BStaley%2C+Christopher%3BHarwood%2C+Valerie+J&rft.aulast=Gordon&rft.aufirst=Katrina&rft.date=2008-03-01&rft.volume=74&rft.issue=6&rft.spage=1704&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Pathogenic bacteria; Nucleotide sequence; Estuaries; DNA; Marine molluscs; Water quality; Disease transmission; Public health; Clinical isolates; Differentiation; Antibodies; Septicemia; Cell number; Polymerase chain reaction; Primers; Pathogens; Population dynamics; rRNA 16S; Mortality; water quality; oysters; Water sampling; Water wells; Assays; Shellfish; Vibrio vulnificus; ASW, USA, Florida; Brackish ER - TY - JOUR T1 - Ethnic, Racial, and Gender Variations in Health Among Farm Operators in the United States AN - 20564435; 9272822 AB - Purpose The purpose of this study was to collect baseline prevalence data on the health problems faced by minority, white, and female farm operators. Methods An occupational health survey of farm operators was conducted by the U.S. Department of Agriculture, National Agricultural Statistics Service between February and August 2000. A stratified random sample of farm operators from 50 U.S. states based on the 1997 Census of Agriculture was selected for telephone interview. Interviews were primarily conducted using a computer assisted telephone instrument system. Results Population prevalences were calculated for 7137 farm operators. Prevalences were greatest for musculoskeletal discomfort, followed by respiratory problems, hearing loss, and hypertension. Generally, Latino and Asian American operators had lower prevalences for health problems than white non-Latino and white operators, respectively. African-American operators had greater prevalences for hypertension, and osteoarthritis, but lower prevalences for hearing loss, skin problems, heart problems, and cancer than white operators. American Indian or Alaska Native operators had higher prevalences for musculoskeletal problems, skin problems, and hypertension. Conclusions Prevalences for the different ethnicity and race groups are not the same. Studies that combine racial and ethnic groups, or study only white and non-Latino farm operators may overestimate or underestimate the prevalence of health conditions in the entire farm operator population. Key Words: Occupational Health; Agricultural Workers; Farm Operators; Surveillance Abbreviations: USDA, United States Department of Agriculture; NASS, National Agricultural Statistics Service; NIOSH, National Institute for Occupational Safety and Health; NHIS, National Health Interview Survey; GHQ, General Health Questionnaire JF - Annals of Epidemiology AU - Alterman, Toni AU - Steege, Andrea L AU - Li, Jia AU - Petersen, Martin R AU - Muntaner, Carles AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, talterman@cdc.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 179 EP - 186 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 18 IS - 3 SN - 1047-2797, 1047-2797 KW - Health & Safety Science Abstracts KW - census KW - Skin KW - Occupational safety KW - agriculture KW - INE, USA, Alaska KW - Hearing loss KW - Cancer KW - musculoskeletal system KW - health problems KW - farms KW - Gender KW - hypertension KW - Respiratory function KW - Ethnic groups KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20564435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Ethnic%2C+Racial%2C+and+Gender+Variations+in+Health+Among+Farm+Operators+in+the+United+States&rft.au=Alterman%2C+Toni%3BSteege%2C+Andrea+L%3BLi%2C+Jia%3BPetersen%2C+Martin+R%3BMuntaner%2C+Carles&rft.aulast=Alterman&rft.aufirst=Toni&rft.date=2008-03-01&rft.volume=18&rft.issue=3&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2007.11.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - census; Skin; Occupational safety; agriculture; Hearing loss; musculoskeletal system; Cancer; health problems; farms; hypertension; Gender; Respiratory function; Ethnic groups; Occupational health; INE, USA, Alaska DO - http://dx.doi.org/10.1016/j.annepidem.2007.11.014 ER - TY - JOUR T1 - Ciprofloxacin-Resistant Salmonella enterica Serotype Typhimurium, China AN - 20334319; 9015097 AB - We characterized 44 Salmonella enterica serotype Typhimurium isolates from Tongji Hospital outpatients in Wuhan, China, May 2002-October 2005. All 31 ciprofloxacin-resistant isolates were also resistant to > 8 other antimicrobial drugs and carried > 2 mutations in GyrA and 1 mutation in ParC. Class 1 integrons were identified in 37 isolates. JF - Emerging Infectious Diseases AU - Cui, Shenghui AU - Li, Jingyun AU - Sun, Ziyong AU - Hu, Changqin AU - Jin, Shaohong AU - Guo, Yunchang AU - Ran, Lu AU - Ma, Yue AD - * State Food and Drug Administration, Beijing, People's Republic of China Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 493 EP - 495 PB - U.S. National Center for Infectious Diseases, 1600 Clifton Rd VL - 14 IS - 3 SN - 1080-6040, 1080-6040 KW - Microbiology Abstracts B: Bacteriology KW - Salmonella Typhimurium KW - outpatients KW - ciprofloxacin KW - resistance KW - dispatch KW - Serotypes KW - Salmonella enterica KW - Mutation KW - Drugs KW - DNA topoisomerase IV KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20334319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Ciprofloxacin-Resistant+Salmonella+enterica+Serotype+Typhimurium%2C+China&rft.au=Cui%2C+Shenghui%3BLi%2C+Jingyun%3BSun%2C+Ziyong%3BHu%2C+Changqin%3BJin%2C+Shaohong%3BGuo%2C+Yunchang%3BRan%2C+Lu%3BMa%2C+Yue&rft.aulast=Cui&rft.aufirst=Shenghui&rft.date=2008-03-01&rft.volume=14&rft.issue=3&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/10.3201%2Feid1403.070857 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Serotypes; Drugs; Mutation; DNA topoisomerase IV; Hospitals; Salmonella enterica DO - http://dx.doi.org/10.3201/eid1403.070857 ER - TY - JOUR T1 - The National study to prevent blood exposure in paramedics: Exposure reporting AN - 20249519; 8891650 AB - Background This survey was conducted to provide national incidence rates and risk factors for exposure to blood among paramedics. The present analysis assesses reporting of exposures to employers. Methods A questionnaire was mailed in 2002-2003 to a national sample of paramedics selected using a two-stage design. Information on exposure reporting was obtained on the two most recent exposures for each of five routes of exposure. Results Forty-nine percent of all exposures to blood and 72% of needlesticks were reported to employers. The main reason for under-reporting was not considering the exposure a significant risk. Females reported significantly more total exposures than males. Reporting of needlesticks was significantly less common among respondents who believed most needlesticks were due to circumstances under the worker's control. Reporting was non-significantly more common among workers who believed reporting exposures helps management prevent future exposures. Reporting may have been positively associated with workplace safety culture. Conclusions This survey indicates there is need to improve the reporting of blood exposures by paramedics to their employers, and more work is needed to understand the reasons for under-reporting. Gender, safety culture, perception of risk, and other personal attitudes may all affect reporting behavior. Am. J. Ind. Med. 51:213-222, 2008. JF - American Journal of Industrial Medicine AU - Boal, Winifred L AU - Leiss, Jack K AU - Sousa, Sara AU - Lyden, Jennifer T AU - Li, Jia AU - Jagger, Janine AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, wboal@cdc.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 213 EP - 222 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 51 IS - 3 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Inventories KW - Medical personnel KW - attitudes KW - Blood KW - Workers KW - safety engineering KW - Perception KW - Risk factors KW - Gender KW - Occupational exposure KW - Emergency medical services KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20249519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=The+National+study+to+prevent+blood+exposure+in+paramedics%3A+Exposure+reporting&rft.au=Boal%2C+Winifred+L%3BLeiss%2C+Jack+K%3BSousa%2C+Sara%3BLyden%2C+Jennifer+T%3BLi%2C+Jia%3BJagger%2C+Janine&rft.aulast=Boal&rft.aufirst=Winifred&rft.date=2008-03-01&rft.volume=51&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20558 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Workers; Inventories; Blood; Perception; Risk factors; Occupational exposure; safety engineering; Gender; attitudes; Medical personnel; Emergency medical services DO - http://dx.doi.org/10.1002/ajim.20558 ER - TY - JOUR T1 - Adverse effects of fullerenes on endothelial cells: Fullerenol C sub(60)(OH) sub(24) induced tissue factor and ICAM-1 membrane expression and apoptosis in vitro AN - 20219173; 10289623 AB - We studied the effects of a C sub(60) water suspension at 4 I14g/mL (nC sub(60)) and the water soluble fullerenol C sub(60)(OH) sub(24) at final concentrations of 1 super(a)100 I14g/mL on human umbilical vein endothelial cells (HUVECs) in culture. We found that a 24 hr treatment of HUVECs with C sub(60)(OH) sub(24) at 100 I14g/mL significantly increased cell surface expression of ICAM-1(CD54) (67 A- 4% CD54 super(+) cells vs. 19 A- 2 % CD54 super(+) cells in control; p & 0.001). In addition, this treatment induced the expression of tissue factor (CD142) on HUVECs (54 A- 20% CD142 super(+) cells vs 4 A- 2% CD142 super(+) cells in control; p = 0.008) and increased exposure of phosphatidylserine (PS) (29 A- 2% PS super(+) cells vs. 12 A- 5% PS super(+) cells in control; p & 0.001). Analysis of cell cycle and DNA fragmentation (TUNEL) showed that both nC sub(60) and C sub(60)(OH) sub(24) caused G1 arrest of HUVECs and C sub(60)(OH) sub(24) induced significant apoptosis (21 A- 2% TUNEL super(+) cells at 100 I14g/mL of C sub(60)(OH) sub(24) vs. 4 A- 2% TUNEL super(+) cells in control; p & 0.001). We also demonstrated that both nC sub(60) and C sub(60)(OH) sub(24) induced a rapid concentration dependent elevation of intracellular calcium [Ca super(2+)] sub(i). This could be inhibited by EGTA, suggesting that the source of [Ca super(2+)] sub(i) in fullerene stimulated calcium flux is predominantly from the extracellular environment. In conclusion, fullerenol C sub(60)(OH) sub(24) had both pro-inflammatory and pro-apoptotic effects on HUVECs, indicating possible adverse effects of fullerenes on the endothelium. JF - International Journal of Nanomedicine AU - Gelderman, Monique P AU - Simakova, Olga AU - Clogston, Jeffrey D AU - Patri, Anil K AU - Siddiqui, Sheena F AU - Vostal, Alexander C AU - Simak, Jan AD - CBER, FDA Rockville, MD USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 59 EP - 68 PB - Dove Medical Press Ltd, Beechfield House Macclesfield SK11 0JL UK VL - 3 IS - 1 SN - 1176-9114, 1176-9114 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - endothelial cells KW - fullerenes KW - tissue factor KW - apoptosis KW - ICAM-1 KW - flow cytometry KW - Cell surface KW - Apoptosis KW - Tissue factor KW - Cell cycle KW - Cell culture KW - umbilical vein KW - Calcium (intracellular) KW - Inflammation KW - Endothelial cells KW - DNA fragmentation KW - phosphatidylserine KW - Fullerenes KW - Endothelium KW - intercellular adhesion molecule 1 KW - Side effects KW - nanotechnology KW - W 30940:Products KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20219173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Nanomedicine&rft.atitle=Adverse+effects+of+fullerenes+on+endothelial+cells%3A+Fullerenol+C+sub%2860%29%28OH%29+sub%2824%29+induced+tissue+factor+and+ICAM-1+membrane+expression+and+apoptosis+in+vitro&rft.au=Gelderman%2C+Monique+P%3BSimakova%2C+Olga%3BClogston%2C+Jeffrey+D%3BPatri%2C+Anil+K%3BSiddiqui%2C+Sheena+F%3BVostal%2C+Alexander+C%3BSimak%2C+Jan&rft.aulast=Gelderman&rft.aufirst=Monique&rft.date=2008-03-01&rft.volume=3&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Nanomedicine&rft.issn=11769114&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell surface; Apoptosis; Tissue factor; Cell cycle; Cell culture; umbilical vein; Inflammation; Calcium (intracellular); Endothelial cells; DNA fragmentation; Fullerenes; phosphatidylserine; intercellular adhesion molecule 1; Endothelium; Side effects; nanotechnology ER - TY - JOUR T1 - Development of an Aerosol System for Uniformly Depositing Bacillus Anthracis Spore Particles on Surfaces AN - 20061312; 8589995 AB - After the anthrax incidents in October 2001, several techniques used for sampling surfaces for biological agents were found to be inadequately validated, especially at low surface loadings. Therefore a test chamber was developed to produce sample sets having targeted surface concentrations of dry biological agent simulant. Dry spore aerosols were initially dispersed into the chamber at relatively high air concentrations, and monitored in real time. The concentration decay (due to stirred settling and dilution) was measured and when the targeted air concentration was reached, the sampling surfaces were uncovered and exposed to the settling particles until >99% of the particles had settled. Multiple agar plates were used to estimate the true colony-forming-unit (CFU) surface concentration. The uniformity of surface loadings was limited by random deposition of small numbers of particles on the surfaces (Poisson distribution) and was characterized by how much greater the observed variability was than that predicted by Poisson statistics. The flow-enhanced powder mixture appeared to affect the spores' ability to grow on the agar medium. Three ways of analyzing the agar plates were used to evaluate the effect of spore coatings on viability and to differentiate between number of spore-containing particles and the number of spores. The presence of spore agglomerates re-suspended by various sample handling activities in the chamber further increased the variability of deposited particles. Based on estimated airborne particle concentration, it was possible to predict mean agar plate concentrations within narrow confidence intervals (CI) at low (4.8 CFU, 95% CI 3.5-6.4), medium (20 CFU, 95% CI 17-23), and high (160 CFU, 95% CI 140-190) concentrations. JF - Aerosol Science & Technology AU - Baron, Paul A AU - Estill, Cherie F AU - Deye, Gregory J AU - Hein, Misty J AU - Beard, Jeremy K AU - Larsen, Lloyd D AU - Dahlstrom, Gregory E AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 159 EP - 172 PB - Taylor & Francis, 325 Chestnut Street Suite 800 Philadelphia PA 19106 USA, [URL:http://www.taylorandfrancis.com/] VL - 42 IS - 3 SN - 0278-6826, 0278-6826 KW - Pollution Abstracts; Microbiology Abstracts B: Bacteriology KW - Agar KW - Powder KW - Aerosols KW - Statistics KW - Particulates KW - anthrax KW - Bacillus anthracis KW - Pollutant deposition KW - Colony-forming cells KW - Anthrax KW - Decay KW - Sampling KW - Coatings KW - P 0000:AIR POLLUTION KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20061312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerosol+Science+%26+Technology&rft.atitle=Development+of+an+Aerosol+System+for+Uniformly+Depositing+Bacillus+Anthracis+Spore+Particles+on+Surfaces&rft.au=Baron%2C+Paul+A%3BEstill%2C+Cherie+F%3BDeye%2C+Gregory+J%3BHein%2C+Misty+J%3BBeard%2C+Jeremy+K%3BLarsen%2C+Lloyd+D%3BDahlstrom%2C+Gregory+E&rft.aulast=Baron&rft.aufirst=Paul&rft.date=2008-03-01&rft.volume=42&rft.issue=3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Aerosol+Science+%26+Technology&rft.issn=02786826&rft_id=info:doi/10.1080%2F02786820801918605 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Powder; Agar; Aerosols; Statistics; Colony-forming cells; Anthrax; Sampling; Coatings; Pollutant deposition; anthrax; Decay; Particulates; Bacillus anthracis DO - http://dx.doi.org/10.1080/02786820801918605 ER - TY - JOUR T1 - Mechanisms of Resistance to Daptomycin in Enterococcus faecium AN - 20026947; 8083395 AB - In this study, we investigated the clonal emergence of daptomycin-resistant Enterococcus faecium strains isolated from a patient with leukocyte adhesion deficiency syndrome. The resistance mechanism in these strains is independent of either equivalent point mutations previously described for Staphylococcus aureus or daptomycin inactivation mechanisms identified in soil bacteria. JF - Antimicrobial Agents & Chemotherapy AU - Montero, Clemente I AU - Stock, Frida AU - Murray, Patrick R AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, 10 Center Drive, MSC 1508, Bethesda, Maryland 20892-1508 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1167 EP - 1170 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Leukocytes KW - Point mutation KW - Staphylococcus aureus KW - daptomycin KW - Enterococcus faecium KW - Soil microorganisms KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20026947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Mechanisms+of+Resistance+to+Daptomycin+in+Enterococcus+faecium&rft.au=Montero%2C+Clemente+I%3BStock%2C+Frida%3BMurray%2C+Patrick+R&rft.aulast=Montero&rft.aufirst=Clemente&rft.date=2008-03-01&rft.volume=52&rft.issue=3&rft.spage=1167&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Point mutation; Leukocytes; daptomycin; Soil microorganisms; Staphylococcus aureus; Enterococcus faecium ER - TY - JOUR T1 - Enhanced Production of Phospholipase C and Perfringolysin O (Alpha and Theta Toxins) in a Gatifloxacin-Resistant Strain of Clostridium perfringens AN - 20013465; 8083419 AB - Clostridium perfringens-induced gas gangrene is mediated by potent extracellular toxins, especially alpha toxin (a phospholipase C [PLC]) and theta toxin (perfringolysin O [PFO], a thiol-activated cytolysin); and antibiotic-induced suppression of toxin synthesis is an important clinical goal. The production of PLC and PFO by a gatifloxacin-induced, fluoroquinolone-resistant mutant strain of C. perfringens, strain 10G, carrying a stable mutation in DNA gyrase was compared with that of the wild-type (WT) parent strain. Zymography (with sheep red blood cell and egg yolk overlays) and time course analysis [with hydrolysis of egg yolk lecithin and O-(4 nitrophenyl-phosphoryl)choline] demonstrated that strain 10G produced more PLC and PFO than the WT strain. Increased toxin production in strain 10G was not related either to differences in growth characteristics between the wild-type and the mutant strain or to nonsynonymous polymorphisms in PLC, PFO, or their known regulatory proteins. Increased PLC and PFO production by strain 10G was associated with increased cytotoxic activity for HT-29 human adenocarcinoma cells and with increased platelet-neutrophil aggregate formation. Four other gatifloxacin-induced gyrase mutants did not show increased toxin production, suggesting that gatifloxacin resistance was not always associated with increased toxin production in all strains of C. perfringens. This is the first report of increased toxin production in a fluoroquinolone-resistant strain of C. perfringens. JF - Antimicrobial Agents & Chemotherapy AU - Rafii, Fatemeh AU - Park, Miseon AU - Bryant, Amy E AU - Johnson, Shemedia J AU - Wagner, Robert D AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. Veterans Affairs Medical Center, Boise, Idaho. University of Washington School of Medicine, Seattle, Washington Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 895 EP - 900 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 3 SN - 0066-4804, 0066-4804 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Clostridium KW - Gas gangrene KW - Sheep red blood cells KW - Gene polymorphism KW - Phospholipase C KW - Clostridium perfringens KW - Lecithin KW - DNA topoisomerase KW - Hydrolysis KW - Gatifloxacin KW - Yolk KW - Toxin A KW - Cytotoxicity KW - regulatory proteins KW - cytolysins KW - Adenocarcinoma KW - Mutation KW - A 01360:Plant Diseases KW - X 24370:Natural Toxins KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20013465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Enhanced+Production+of+Phospholipase+C+and+Perfringolysin+O+%28Alpha+and+Theta+Toxins%29+in+a+Gatifloxacin-Resistant+Strain+of+Clostridium+perfringens&rft.au=Rafii%2C+Fatemeh%3BPark%2C+Miseon%3BBryant%2C+Amy+E%3BJohnson%2C+Shemedia+J%3BWagner%2C+Robert+D&rft.aulast=Rafii&rft.aufirst=Fatemeh&rft.date=2008-03-01&rft.volume=52&rft.issue=3&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gas gangrene; Sheep red blood cells; Phospholipase C; Gene polymorphism; DNA topoisomerase; Lecithin; Hydrolysis; Yolk; Gatifloxacin; Toxin A; Cytotoxicity; cytolysins; regulatory proteins; Adenocarcinoma; Mutation; Clostridium; Clostridium perfringens ER - TY - JOUR T1 - Lipid excipients and delivery systems for pharmaceutical development: A regulatory perspective AN - 19902459; 8769357 AB - The use of lipid-based dosage forms for enhancement of drug absorption or delivery has drawn considerable interest from pharmaceutical scientists. The unique characteristics of these dosage forms, however, present significant challenges to pharmaceutical industry and regulatory agencies in many ways. For example, safety assessment is necessary when the use of a new lipid excipient is considered. An important question for lipid formulation is whether the drug remains in solubilised form along the gastrointestinal (GI) tract after it is administered. Certain lipid excipients and surfactants have been reported to change intestinal permeability or interfere with enzyme/transporter activity, thereby affecting drug bioavailability. The potential influence of biopharmaceutical and/or pathophysiological factors on the drug or lipid excipient(s) needs to be explored. For a complex lipid- based dosage form, the conventional in vitro dissolution methods may not be appropriate for predicting in vivo performance in view of the convoluted GI processing of the lipid vehicle and formulation Of paramount importance is to identify any gaps in the scientific understanding of lipid- based dosage forms so that regulatory issues can be addressed. More mechanistic studies should be encouraged to facilitate a better understanding of the pharmaceutical characteristics of lipid formulations and complex interactions between lipid excipient, drug and physiological environment. This review discusses some regulatory considerations in the use of lipid excipients and delivery systems for pharmaceutical development. Implications in the regulatory determination of pharmaceutical equivalence, bioequivalence and therapeutic equivalence are also illustrated. JF - Advanced Drug Delivery Reviews AU - Chen, Mei-Ling AD - Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration 10903 New Hampshire Avenue, Building 21, Room. 3508 Silver Spring, MD 20993-0002, USA, meiling.chen@fda.hhs.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 768 EP - 777 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 60 IS - 6 SN - 0169-409X, 0169-409X KW - Biotechnology and Bioengineering Abstracts KW - Bioavailability KW - Permeability KW - Drug delivery KW - Lipids KW - Intestine KW - Dissolution KW - Enzymes KW - Pharmaceuticals KW - Gastrointestinal tract KW - Surfactants KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19902459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Lipid+excipients+and+delivery+systems+for+pharmaceutical+development%3A+A+regulatory+perspective&rft.au=Chen%2C+Mei-Ling&rft.aulast=Chen&rft.aufirst=Mei-Ling&rft.date=2008-03-01&rft.volume=60&rft.issue=6&rft.spage=768&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2007.09.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Lipids; Pharmaceuticals; Drug delivery; Gastrointestinal tract; Surfactants; Enzymes; Intestine; Dissolution; Permeability; Bioavailability DO - http://dx.doi.org/10.1016/j.addr.2007.09.010 ER - TY - JOUR T1 - The Use of Immunochemical and Biosensor Methods for Occupational and Environmental Monitoring. Part II: Immunoassay Data Analysis and Immunobiosensors AN - 19488784; 8502039 AB - Abstract not available. JF - Journal of Occupational and Environmental Hygiene AU - Ashley, Kevin AU - Biagini, Raymond E AU - Smith, Jerry P AU - Sammons, Deborah L AU - MacKenzie, Barbara A AU - Striley, Cynthia A F AU - Robertson, Shirley K AU - Snawder, John E AD - Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - D37 EP - D42 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 3 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Biotechnology and Bioengineering Abstracts; Health & Safety Science Abstracts KW - Environmental monitoring KW - Biosensors KW - Data processing KW - Immunoassays KW - Environmental hygiene KW - W 30955:Biosensors KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19488784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=The+Use+of+Immunochemical+and+Biosensor+Methods+for+Occupational+and+Environmental+Monitoring.+Part+II%3A+Immunoassay+Data+Analysis+and+Immunobiosensors&rft.au=Ashley%2C+Kevin%3BBiagini%2C+Raymond+E%3BSmith%2C+Jerry+P%3BSammons%2C+Deborah+L%3BMacKenzie%2C+Barbara+A%3BStriley%2C+Cynthia+A+F%3BRobertson%2C+Shirley+K%3BSnawder%2C+John+E&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2008-03-01&rft.volume=5&rft.issue=3&rft.spage=D37&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701798224 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Biosensors; Environmental monitoring; Data processing; Immunoassays; Environmental hygiene DO - http://dx.doi.org/10.1080/15459620701798224 ER - TY - JOUR T1 - Analysis of Nonstandard Noise Dosimeter Microphone Positions AN - 19374241; 8502048 AB - This study was conducted as part of a project involving the evaluation of a new type of noise exposure monitoring paradigm. Laboratory tests were conducted to assess how 'nonstandard' dosimeter microphones and microphone positions measured noise levels under different acoustical conditions (i.e., diffuse field and direct field). The data presented in this article reflect measurement differences due to microphone position and mounting/porting structure only and are not an evaluation of any particular complete dosimeter system. To varying degrees, the results obtained with the dosimeter microphones used in this study differed from the reference results obtained in the unperturbed (subject absent) sound field with a precision (suitable for use in an ANSI Type 1 sound level meter) 1/2-inch (12.7 mm) measurement microphone. Effects of dosimeter microphone placement in a diffuse field were found to be minor for most of the test microphones/locations, while direct field microphone placement effects were found to be quite large depending on the microphone position and supporting structure, sound source location, and noise spectrum. JF - Journal of Occupational and Environmental Hygiene AU - Byrne, David C AU - Reeves, Efrem R AD - Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 197 EP - 209 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 3 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Laboratory testing KW - microphones KW - Noise levels KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19374241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Analysis+of+Nonstandard+Noise+Dosimeter+Microphone+Positions&rft.au=Byrne%2C+David+C%3BReeves%2C+Efrem+R&rft.aulast=Byrne&rft.aufirst=David&rft.date=2008-03-01&rft.volume=5&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701879438 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Laboratory testing; microphones; Noise levels DO - http://dx.doi.org/10.1080/15459620701879438 ER - TY - JOUR T1 - Survey of furan in heat processed foods by headspace gas chromatography/mass spectrometry and estimated adult exposure AN - 19339885; 8681825 AB - Furan is a suspected human carcinogen that is formed in some processed foods at low ng per g levels. Recent improvements in analytical methodology and scientific instrumentation have made it possible to accurately measure the amount of furan in a wide variety of foods. Results from analysis of more than 300 processed foods are presented. Furan was found at levels ranging from non-detectable (LOD, 0.2-0.9 ng g-1) to over 100 ng g-1. Exposure estimates for several adult food types were calculated, with brewed coffee being the major source of furan in the adult diet (0.15 mg kg-1 body weight day-1). Estimates of mean exposure to furan for different subpopulations were calculated. For consumers 2 years and older, the intake is estimated to be about 0.2 mg kg-1 body weight day-1. JF - Food Additives & Contaminants Part A Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Morehouse, Kim M AU - Nyman, Patricia J AU - McNeal, Timothy P AU - Dinovi, Michael J AU - Perfetti, Gracia A AD - Food and Drug Administration-CFSAN, College Park, MD 20740, USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 259 EP - 264 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 25 IS - 3 SN - 0265-203X, 0265-203X KW - Risk Abstracts KW - Risk assessment KW - Diets KW - coffee KW - Mass spectrometry KW - Carcinogens KW - Furans KW - Food additives KW - subpopulations KW - Gas chromatography KW - body weight UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19339885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Survey+of+furan+in+heat+processed+foods+by+headspace+gas+chromatography%2Fmass+spectrometry+and+estimated+adult+exposure&rft.au=Morehouse%2C+Kim+M%3BNyman%2C+Patricia+J%3BMcNeal%2C+Timothy+P%3BDinovi%2C+Michael+J%3BPerfetti%2C+Gracia+A&rft.aulast=Morehouse&rft.aufirst=Kim&rft.date=2008-03-01&rft.volume=25&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants+Part+A+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=0265203X&rft_id=info:doi/10.1080%2F02652030701552949 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Furans; body weight; Food additives; Diets; Risk assessment; Mass spectrometry; coffee; Carcinogens; Gas chromatography; subpopulations DO - http://dx.doi.org/10.1080/02652030701552949 ER - TY - JOUR T1 - Performance evaluation of cytometric bead assays for the measurement of lung cytokines in two rodent models AN - 20869816; 8244799 AB - There is a growing demand for a cost-effective, efficient, and high-throughput method for measuring cytokines. Currently, many studies are using flow cytometric bead-based multiplex assays in the measurement of cytokines. However, limited data are available regarding the performance of these cytometric bead assays versus enzyme-linked immunosorbent assay (ELISA) or correlation with mRNA expression using real time reverse transcriptase-polymerase chain reaction (RT-PCR). In one of our studies, cytometric bead array (CBA) was used to measure inflammatory cytokine protein levels in bronchoalveolar lavage (BAL) samples from mice exposed to welding fume, an inflammatory particulate. The results were then compared to whole lung mRNA levels of the same cytokines measured by real time RT-PCR in the same mouse model. It was found that the trends in cytokine profiles measured via CBA agreed with the whole lung mRNA results. In a separate experiment, we used a rat zymosan infectivity model to induce a pulmonary immunomodulatory response and determined cytokine concentrations in recovered BAL fluid by ELISA and two different types of cytometric bead-based assays, CBA and FlowCytomix (FC). The sample-to-sample correlation was good between ELISA and CBA with correlation coefficient R values of 0.76, 0.66, and 0.92 for rat IFN- gamma , TNF- alpha , and IL-6, respectively. ELISA only correlated significantly with the FC assay for TNF- alpha with R=0.43. Patterns of cytokine response in our rat model also differed among the assays but overall, the ELISA and CBA yielded similar results. For a method-to-method comparison, we assayed supplied cytokine standards from ELISA kits using both ELISA and CBA to determine the R values and found it to be greater than 0.90 for all the cytokines tested. It was found that the ELISA was more sensitive in the low range of the standard curve while the bead assays were capable of detecting higher protein concentrations, which would allow for direct measurement of concentrated samples. There was a lack of agreement between the absolute protein values for the ELISA and flow cytometric bead-based assays; in most cases, the latter method tended to give higher protein concentrations than ELISA. In conclusion, direct comparisons between absolute protein values did not agree among the assays tested in this study, but patterns of cytokine response generally agreed between ELISA and CBA. In the case of the mouse CBA, a companion measurement is recommended if samples with low concentrations of an analyte are reported and extrapolated below sensitivity or zero. JF - Journal of Immunological Methods AU - Young, SH AU - Antonini, J M AU - Roberts, J R AU - Erdely, AD AU - Zeidler-Erdely, P C AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States, syoung@cdc.gov Y1 - 2008/02/29/ PY - 2008 DA - 2008 Feb 29 SP - 59 EP - 68 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 331 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Interleukin 6 KW - gamma -Interferon KW - Fc KW - Enzyme-linked immunosorbent assay KW - Fumes KW - Data processing KW - Animal models KW - Alveoli KW - Inflammation KW - Gene expression KW - Flow cytometry KW - Infectivity KW - Bronchus KW - Lung KW - Polymerase chain reaction KW - Cytokines KW - Welding KW - Tumor necrosis factor- alpha KW - F 06900:Methods KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20869816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Performance+evaluation+of+cytometric+bead+assays+for+the+measurement+of+lung+cytokines+in+two+rodent+models&rft.au=Young%2C+SH%3BAntonini%2C+J+M%3BRoberts%2C+J+R%3BErdely%2C+AD%3BZeidler-Erdely%2C+P+C&rft.aulast=Young&rft.aufirst=SH&rft.date=2008-02-29&rft.volume=331&rft.issue=1-2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2007.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Fc; gamma -Interferon; Enzyme-linked immunosorbent assay; Data processing; Fumes; Animal models; Alveoli; Inflammation; Flow cytometry; Gene expression; Infectivity; Bronchus; Lung; Welding; Cytokines; Polymerase chain reaction; Tumor necrosis factor- alpha DO - http://dx.doi.org/10.1016/j.jim.2007.11.004 ER - TY - CPAPER T1 - A Microcentrifuge-Tube Sampler: Development and Application T2 - 7th International Symposium on Advanced Environmental Monitoring (ISAEM 2008) AN - 40787870; 4789126 JF - 7th International Symposium on Advanced Environmental Monitoring (ISAEM 2008) AU - Chen, Bean T Y1 - 2008/02/25/ PY - 2008 DA - 2008 Feb 25 KW - Samplers KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40787870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Symposium+on+Advanced+Environmental+Monitoring+%28ISAEM+2008%29&rft.atitle=A+Microcentrifuge-Tube+Sampler%3A+Development+and+Application&rft.au=Chen%2C+Bean+T&rft.aulast=Chen&rft.aufirst=Bean&rft.date=2008-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Symposium+on+Advanced+Environmental+Monitoring+%28ISAEM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://ademrc.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Universal Virus Detection T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40839208; 4809165 DE: JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Uhlenhaut, C AU - Nanda, S AU - Tang, S AU - SierraHonigmann, A AU - Krause, P R Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Universal+Virus+Detection&rft.au=Uhlenhaut%2C+C%3BNanda%2C+S%3BTang%2C+S%3BSierraHonigmann%2C+A%3BKrause%2C+P+R&rft.aulast=Uhlenhaut&rft.aufirst=C&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Species Neutral Protein G ELISA for Evaluation of Plague Vaccine Efficacy T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40838499; 4809227 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Meysick, K AU - Falconio, J AU - Schlomer, J Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Vaccines KW - Protein G KW - ELISA KW - Plague KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40838499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Development+of+a+Species+Neutral+Protein+G+ELISA+for+Evaluation+of+Plague+Vaccine+Efficacy&rft.au=Meysick%2C+K%3BFalconio%2C+J%3BSchlomer%2C+J&rft.aulast=Meysick&rft.aufirst=K&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation of Francisella tularensis from Foods using the Pathatrix Immunomagnetic Capture System T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40836094; 4809149 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Hanes, D E AU - EwingPeeples, L AU - Kothary, M H AU - Tall, B D Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Food KW - Francisella tularensis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Isolation+of+Francisella+tularensis+from+Foods+using+the+Pathatrix+Immunomagnetic+Capture+System&rft.au=Hanes%2C+D+E%3BEwingPeeples%2C+L%3BKothary%2C+M+H%3BTall%2C+B+D&rft.aulast=Hanes&rft.aufirst=D&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing the Population Diversity of Escherichia coli T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40829469; 4809118 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Cebula, Thomas A Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Species diversity KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40829469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Probing+the+Population+Diversity+of+Escherichia+coli&rft.au=Cebula%2C+Thomas+A&rft.aulast=Cebula&rft.aufirst=Thomas&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Smallpox Vaccines and IgG Preparations by Bioimaging of TK+ Vaccinia Luciferase Virus Dissemination in Live Mice T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40828406; 4809068 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Zaitseva, M AU - Manischewitz, J AU - King, L AU - Nielsen, H AU - Golding, H Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Vaccines KW - Mice KW - Smallpox KW - Immunoglobulin G KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40828406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Evaluation+of+Smallpox+Vaccines+and+IgG+Preparations+by+Bioimaging+of+TK%2B+Vaccinia+Luciferase+Virus+Dissemination+in+Live+Mice&rft.au=Zaitseva%2C+M%3BManischewitz%2C+J%3BKing%2C+L%3BNielsen%2C+H%3BGolding%2C+H&rft.aulast=Zaitseva&rft.aufirst=M&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of Food Safety: Bacterial Pathogens and Toxins T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40825058; 4809108 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Acheson, David Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Pathogens KW - Toxins KW - Reviews KW - Food KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40825058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Overview+of+Food+Safety%3A+Bacterial+Pathogens+and+Toxins&rft.au=Acheson%2C+David&rft.aulast=Acheson&rft.aufirst=David&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Household vacuum cleaners vs. the high-volume surface sampler for collection of carpet dust samples in epidemiologic studies of children. AN - 70379604; 18291036 AB - Levels of pesticides and other compounds in carpet dust can be useful indicators of exposure in epidemiologic studies, particularly for young children who are in frequent contact with carpets. The high-volume surface sampler (HVS3) is often used to collect dust samples in the room in which the child had spent the most time. This method can be expensive and cumbersome, and it has been suggested that an easier method would be to remove dust that had already been collected with the household vacuum cleaner. However, the household vacuum integrates exposures over multiple rooms, some of which are not relevant to the child's exposure, and differences in vacuuming equipment and practices could affect the chemical concentration data. Here, we compare levels of pesticides and other compounds in dust from household vacuums to that collected using the HVS3. Both methods were used in 45 homes in California. HVS3 samples were collected in one room, while the household vacuum had typically been used throughout the home. The samples were analyzed for 64 organic compounds, including pesticides, polycyclic aromatic hydrocarbons, and polychlorinated biphenyls (PCBs), using GC/MS in multiple ion monitoring mode; and for nine metals using conventional microwave-assisted acid digestion combined with ICP/MS. The methods agreed in detecting the presence of the compounds 77% to 100% of the time (median 95%). For compounds with less than 100% agreement, neither method was consistently more sensitive than the other. Median concentrations were similar for most analytes, and Spearman correlation coefficients were 0.60 or higher except for allethrin (0.15) and malathion (0.24), which were detected infrequently, and benzo(k)fluoranthene (0.55), benzo(a)pyrene (0.55), PCB 105 (0.54), PCB 118 (0.54), and PCB 138 (0.58). Assuming that the HVS3 method is the "gold standard," the extent to which the household vacuum cleaner method yields relative risk estimates closer to unity by increasing random measurement error varies by compound and depends on the method used to calculate relative risk. The household vacuum cleaner method appears to be a reasonable alternative to the HVS3 for detecting, ranking, and quantifying the concentrations of pesticides and other compounds in carpet dust. JF - Environmental health : a global access science source AU - Colt, Joanne S AU - Gunier, Robert B AU - Metayer, Catherine AU - Nishioka, Marcia G AU - Bell, Erin M AU - Reynolds, Peggy AU - Buffler, Patricia A AU - Ward, Mary H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd. MSC 7240, Bethesda, MD, 20892-7240, USA. coltj@mail.nih.gov Y1 - 2008/02/21/ PY - 2008 DA - 2008 Feb 21 SP - 6 VL - 7 KW - Dust KW - 0 KW - Pesticide Residues KW - Index Medicus KW - Housekeeping KW - California KW - Epidemiologic Studies KW - Humans KW - Environmental Exposure -- analysis KW - Pesticide Residues -- isolation & purification KW - Floors and Floorcoverings KW - Dust -- analysis KW - Specimen Handling -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70379604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+%3A+a+global+access+science+source&rft.atitle=Household+vacuum+cleaners+vs.+the+high-volume+surface+sampler+for+collection+of+carpet+dust+samples+in+epidemiologic+studies+of+children.&rft.au=Colt%2C+Joanne+S%3BGunier%2C+Robert+B%3BMetayer%2C+Catherine%3BNishioka%2C+Marcia+G%3BBell%2C+Erin+M%3BReynolds%2C+Peggy%3BBuffler%2C+Patricia+A%3BWard%2C+Mary+H&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2008-02-21&rft.volume=7&rft.issue=&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Environmental+health+%3A+a+global+access+science+source&rft.issn=1476-069X&rft_id=info:doi/10.1186%2F1476-069X-7-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-10 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Air Waste Manag Assoc. 2001 Mar;51(3):339-51 [11266098] Breast Cancer Res Treat. 2002 Jun;74(3):235-54 [12206514] Int J Epidemiol. 1989 Sep;18(3):705-12 [2807678] Sci Total Environ. 1990 Jan;90:13-29 [2305239] J Expo Anal Environ Epidemiol. 1991 Apr;1(2):143-55 [1844216] Arch Environ Contam Toxicol. 1994 Jan;26(1):37-46 [8110022] J Expo Sci Environ Epidemiol. 2007 Jul;17(4):331-49 [16736054] Environ Health Perspect. 1995 Dec;103(12):1126-34 [8747019] J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217-34 [9185013] Environ Health Perspect. 1998 Nov;106(11):721-4 [9799187] Environ Health Perspect. 1999 Sep;107(9):721-6 [10464072] Epidemiology. 2005 Jul;16(4):516-25 [15951670] Am J Epidemiol. 2006 Jun 15;163(12):1091-100 [16597704] Environ Res. 1995 Feb;68(2):114-23 [7601072] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1476-069X-7-6 ER - TY - JOUR T1 - Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. AN - 70326535; 18297132 AB - Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure. We performed gene expression analysis using HG-U133A Affymetrix chips on 135 fresh frozen tissue samples of adenocarcinoma and paired noninvolved lung tissue from current, former and never smokers, with biochemically validated smoking information. ANOVA analysis adjusted for potential confounders, multiple testing procedure, Gene Set Enrichment Analysis, and GO-functional classification were conducted for gene selection. Results were confirmed in independent adenocarcinoma and non-tumor tissues from two studies. We identified a gene expression signature characteristic of smoking that includes cell cycle genes, particularly those involved in the mitotic spindle formation (e.g., NEK2, TTK, PRC1). Expression of these genes strongly differentiated both smokers from non-smokers in lung tumors and early stage tumor tissue from non-tumor tissue (p1.5, for each comparison), consistent with an important role for this pathway in lung carcinogenesis induced by smoking. These changes persisted many years after smoking cessation. NEK2 (p<0.001) and TTK (p = 0.002) expression in the noninvolved lung tissue was also associated with a 3-fold increased risk of mortality from lung adenocarcinoma in smokers. Our work provides insight into the smoking-related mechanisms of lung neoplasia, and shows that the very mitotic genes known to be involved in cancer development are induced by smoking and affect survival. These genes are candidate targets for chemoprevention and treatment of lung cancer in smokers. JF - PloS one AU - Landi, Maria Teresa AU - Dracheva, Tatiana AU - Rotunno, Melissa AU - Figueroa, Jonine D AU - Liu, Huaitian AU - Dasgupta, Abhijit AU - Mann, Felecia E AU - Fukuoka, Junya AU - Hames, Megan AU - Bergen, Andrew W AU - Murphy, Sharon E AU - Yang, Ping AU - Pesatori, Angela C AU - Consonni, Dario AU - Bertazzi, Pier Alberto AU - Wacholder, Sholom AU - Shih, Joanna H AU - Caporaso, Neil E AU - Jen, Jin AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA. Y1 - 2008/02/20/ PY - 2008 DA - 2008 Feb 20 SP - 1 VL - 3 IS - 2 KW - Index Medicus KW - Humans KW - Gene Expression Regulation KW - Biopsy KW - Cell Transformation, Neoplastic KW - Gene Expression Profiling KW - Lung Neoplasms -- etiology KW - Genes, cdc KW - Adenocarcinoma -- etiology KW - Smoking -- adverse effects KW - Smoking -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70326535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Gene+expression+signature+of+cigarette+smoking+and+its+role+in+lung+adenocarcinoma+development+and+survival.&rft.au=Landi%2C+Maria+Teresa%3BDracheva%2C+Tatiana%3BRotunno%2C+Melissa%3BFigueroa%2C+Jonine+D%3BLiu%2C+Huaitian%3BDasgupta%2C+Abhijit%3BMann%2C+Felecia+E%3BFukuoka%2C+Junya%3BHames%2C+Megan%3BBergen%2C+Andrew+W%3BMurphy%2C+Sharon+E%3BYang%2C+Ping%3BPesatori%2C+Angela+C%3BConsonni%2C+Dario%3BBertazzi%2C+Pier+Alberto%3BWacholder%2C+Sholom%3BShih%2C+Joanna+H%3BCaporaso%2C+Neil+E%3BJen%2C+Jin&rft.aulast=Landi&rft.aufirst=Maria&rft.date=2008-02-20&rft.volume=3&rft.issue=2&rft.spage=e1651&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0001651 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-15 N1 - Date created - 2008-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2000 Jan;82(1):65-73 [10638968] Nat Med. 2007 Jul;13(7):820-7 [17589519] Nat Genet. 2000 May;25(1):25-9 [10802651] Cancer Res. 2000 Nov 1;60(21):6116-33 [11085536] Cancer Res. 2002 Jun 1;62(11):3244-50 [12036940] J Cell Biol. 2002 Aug 19;158(4):617-23 [12177045] Nat Cell Biol. 2002 Dec;4(12):976-80 [12447387] Genome Biol. 2003;4(4):R28 [12702209] Am J Respir Cell Mol Biol. 2003 Aug;29(2):157-62 [12600827] Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):445-53 [15006922] J Biol Chem. 2004 May 7;279(19):20049-57 [14978040] Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10143-8 [15210990] J Cell Biol. 2004 Sep 27;166(7):949-55 [15452138] Chest. 2007 Jul;132(1):185-92 [17573517] Mol Biol Cell. 2007 Oct;18(10):4024-36 [17671160] Proc Am Thorac Soc. 2007 Jan;4(1):127-32 [17202302] Cancer Res. 1999 Feb 1;59(3):590-6 [9973205] Nat Rev Cancer. 2004 Dec;4(12):927-36 [15573114] Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30 [15983384] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 [16199517] Am J Respir Crit Care Med. 2005 Dec 1;172(11):1383-92 [16166618] J Mol Med (Berl). 2006 Apr;84(4):318-28 [16520944] Bioinformatics. 2006 Apr 15;22(8):943-9 [16473874] J Pathol. 2006 Oct;210(2):192-204 [16915569] J Mol Med (Berl). 2007 Jan;85(1):39-53 [17115125] Nat Rev Cancer. 2007 Mar;7(3):169-81 [17318210] Carcinogenesis. 2007 May;28(5):899-912 [17259655] Cancer Res. 2000 Apr 1;60(7):1949-60 [10766185] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0001651 ER - TY - JOUR T1 - The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex. AN - 70303744; 18201836 AB - The anesthetic gas nitrous oxide (N2O) and the volatile anesthetic isoflurane (ISO) are commonly used in surgical procedures for human infants and in veterinary and laboratory animal practice to produce loss of consciousness and analgesia. Recent reports indicate that exposure of the developing brain to general anesthetics that block N-methyl-D-aspartate (NMDA) glutamate receptors or potentiate GABA(A) receptors can trigger widespread apoptotic neurodegeneration. In the present study, the question arises whether a relatively low dose of ISO alone or its combination with N2O entails significant risk of inducing enhanced apoptosis. In addition, the role of L-carnitine to attenuate these effects was also examined. Postnatal day 7 (PND-7) rat pups were exposed to N2O (75%) or a low dose of ISO (0.55%) alone, or N2O plus ISO for 2, 4, 6 or 8 h with or without L-carnitine. The neurotoxic effects were evaluated 6 h after completion of anesthetic administration. No significant neurotoxic effects were observed for the animals exposed to N2O or ISO alone. However, enhanced apoptotic cell death was apparent when N2O was combined with ISO at exposure durations of 6 h or more. Co-administration of L-carnitine (300 or 500 mg/kg, i.p.) effectively protected neurons from the anesthetic-induced damage. These data indicate that 6 h or more of inhaled anesthetic exposure consisting of a combination of N2O and ISO results in enhanced neuronal apoptosis, and L-carnitine effectively blocks the neuronal apoptosis caused by inhalation anesthetics in the developing rat brain. JF - Neuroscience AU - Zou, X AU - Sadovova, N AU - Patterson, T A AU - Divine, R L AU - Hotchkiss, C E AU - Ali, S F AU - Hanig, J P AU - Paule, M G AU - Slikker, W AU - Wang, C AD - Division of Neurotoxicology, National Center for Toxicological Research, HFT-132, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2008/02/19/ PY - 2008 DA - 2008 Feb 19 SP - 1053 EP - 1065 VL - 151 IS - 4 SN - 0306-4522, 0306-4522 KW - Anesthetics, Inhalation KW - 0 KW - Bcl2l1 protein, rat KW - Drug Combinations KW - Fluoresceins KW - Neural Cell Adhesion Molecule L1 KW - Organic Chemicals KW - Sialic Acids KW - bcl-2-Associated X Protein KW - bcl-X Protein KW - fluoro jade KW - polysialyl neural cell adhesion molecule KW - Vitamin B Complex KW - 12001-76-2 KW - Isoflurane KW - CYS9AKD70P KW - Caspase 3 KW - EC 3.4.22.- KW - Nitrous Oxide KW - K50XQU1029 KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Animals KW - Nitrous Oxide -- toxicity KW - Dose-Response Relationship, Drug KW - Isoflurane -- toxicity KW - Neural Cell Adhesion Molecule L1 -- metabolism KW - Sialic Acids -- metabolism KW - bcl-X Protein -- metabolism KW - bcl-2-Associated X Protein -- metabolism KW - Rats KW - Animals, Newborn KW - Rats, Sprague-Dawley KW - Time Factors KW - Caspase 3 -- metabolism KW - Vitamin B Complex -- pharmacology KW - Frontal Lobe -- cytology KW - Anesthetics, Inhalation -- toxicity KW - Neurons -- drug effects KW - Carnitine -- pharmacology KW - Neurons -- cytology KW - Apoptosis -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70303744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=The+effects+of+L-carnitine+on+the+combination+of%2C+inhalation+anesthetic-induced+developmental%2C+neuronal+apoptosis+in+the+rat+frontal+cortex.&rft.au=Zou%2C+X%3BSadovova%2C+N%3BPatterson%2C+T+A%3BDivine%2C+R+L%3BHotchkiss%2C+C+E%3BAli%2C+S+F%3BHanig%2C+J+P%3BPaule%2C+M+G%3BSlikker%2C+W%3BWang%2C+C&rft.aulast=Zou&rft.aufirst=X&rft.date=2008-02-19&rft.volume=151&rft.issue=4&rft.spage=1053&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2007.12.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-12 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2007.12.013 ER - TY - CPAPER T1 - Volume Error Analysis for Lung Nodules Attached to Bronchial Vessels in an Anthropomorphic Thoracic Phantom T2 - Conference on Computer-Aided Diagnosis (MI03) AN - 40723949; 4761563 JF - Conference on Computer-Aided Diagnosis (MI03) AU - Kinnard, Lisa M AU - Gavrielides, Marios A AU - Peregoy, Jennifer AU - Pritchard, William F AU - Petrick, Nicholas A AU - Myers, Kyle J Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Lung nodules KW - Nodules KW - Thorax KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40723949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.atitle=Volume+Error+Analysis+for+Lung+Nodules+Attached+to+Bronchial+Vessels+in+an+Anthropomorphic+Thoracic+Phantom&rft.au=Kinnard%2C+Lisa+M%3BGavrielides%2C+Marios+A%3BPeregoy%2C+Jennifer%3BPritchard%2C+William+F%3BPetrick%2C+Nicholas+A%3BMyers%2C+Kyle+J&rft.aulast=Kinnard&rft.aufirst=Lisa&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783653&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Display Methods for Adjustable Grayscale and Luminance Depth T2 - Conference on PACS and Imaging Informatics (MI07) AN - 40720165; 4761891 DE: JF - Conference on PACS and Imaging Informatics (MI07) AU - Xu, An AU - Saha, Anindita AU - Guarnieri, Gabriele AU - Ramponi, Giovanni AU - Badano, Aldo Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+PACS+and+Imaging+Informatics+%28MI07%29&rft.atitle=Display+Methods+for+Adjustable+Grayscale+and+Luminance+Depth&rft.au=Xu%2C+An%3BSaha%2C+Anindita%3BGuarnieri%2C+Gabriele%3BRamponi%2C+Giovanni%3BBadano%2C+Aldo&rft.aulast=Xu&rft.aufirst=An&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+PACS+and+Imaging+Informatics+%28MI07%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783661&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Singular Vectors of an Imaging Sytem Matrix as Efficient Channels for the Ideal Observer in Detection Tasks Involving Non-Gaussian Distributed Lumpy Images T2 - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AN - 40719657; 4761742 JF - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AU - Witten, Joel M AU - Park, Subok AU - Myers, Kyle J Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Channels KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40719657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=Singular+Vectors+of+an+Imaging+Sytem+Matrix+as+Efficient+Channels+for+the+Ideal+Observer+in+Detection+Tasks+Involving+Non-Gaussian+Distributed+Lumpy+Images&rft.au=Witten%2C+Joel+M%3BPark%2C+Subok%3BMyers%2C+Kyle+J&rft.aulast=Witten&rft.aufirst=Joel&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783657&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hybrid Linear Classifier for Jointly Normal Data: Theory T2 - Conference on Computer-Aided Diagnosis (MI03) AN - 40719305; 4761486 JF - Conference on Computer-Aided Diagnosis (MI03) AU - Chen, Weijie AU - Metz, Charles E AU - Giger, Maryellen L Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Hybrids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40719305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.atitle=Hybrid+Linear+Classifier+for+Jointly+Normal+Data%3A+Theory&rft.au=Chen%2C+Weijie%3BMetz%2C+Charles+E%3BGiger%2C+Maryellen+L&rft.aulast=Chen&rft.aufirst=Weijie&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783653&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Markov-Chain Monte Carlo for the Performance of a Channelized-Ideal Observer in Detection Tasks with Non-Gaussian Lumpy Backgrounds T2 - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AN - 40719190; 4761741 JF - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AU - Park, Subok AU - Clarkson, Eric W Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Statistical analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40719190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=Markov-Chain+Monte+Carlo+for+the+Performance+of+a+Channelized-Ideal+Observer+in+Detection+Tasks+with+Non-Gaussian+Lumpy+Backgrounds&rft.au=Park%2C+Subok%3BClarkson%2C+Eric+W&rft.aulast=Park&rft.aufirst=Subok&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783657&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparisons of Two Agreement Measures T2 - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AN - 40715810; 4761702 DE: JF - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AU - Liu, Weimin AU - Gallas, Brandon D Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=Comparisons+of+Two+Agreement+Measures&rft.au=Liu%2C+Weimin%3BGallas%2C+Brandon+D&rft.aulast=Liu&rft.aufirst=Weimin&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783657&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparing Signal-Based and Case-Based Methodologies for CAD Assessment in a Detection Task T2 - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AN - 40714159; 4761697 JF - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AU - Paquerault, Sophie AU - Samuelson, Frank W AU - Petrick, Nicholas A AU - Myers, Kyle J Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Technology assessment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40714159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=Comparing+Signal-Based+and+Case-Based+Methodologies+for+CAD+Assessment+in+a+Detection+Task&rft.au=Paquerault%2C+Sophie%3BSamuelson%2C+Frank+W%3BPetrick%2C+Nicholas+A%3BMyers%2C+Kyle+J&rft.aulast=Paquerault&rft.aufirst=Sophie&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783657&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Efficient Depth- and Energy-Dependent Monte Carlo Model for Columnar CsI Detector T2 - Conference on Physics of Medical Imaging (MI01) AN - 40714031; 4761130 JF - Conference on Physics of Medical Imaging (MI01) AU - Kyprianou, Iacovos S AU - Brackman, Gabriel AU - Badal, Andreu AU - Myers, Kyle J AU - Badano, Aldo Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Models KW - Statistical analysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40714031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Physics+of+Medical+Imaging+%28MI01%29&rft.atitle=An+Efficient+Depth-+and+Energy-Dependent+Monte+Carlo+Model+for+Columnar+CsI+Detector&rft.au=Kyprianou%2C+Iacovos+S%3BBrackman%2C+Gabriel%3BBadal%2C+Andreu%3BMyers%2C+Kyle+J%3BBadano%2C+Aldo&rft.aulast=Kyprianou&rft.aufirst=Iacovos&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Physics+of+Medical+Imaging+%28MI01%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783650&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Model Observer for the Assessment of Display Temporal Characteristics T2 - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AN - 40713856; 4761738 JF - Conference on Image Perception, Observer Performance, and Technology Assessment (MI05) AU - Liang, Hongye AU - Badano, Aldo Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40713856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.atitle=A+Model+Observer+for+the+Assessment+of+Display+Temporal+Characteristics&rft.au=Liang%2C+Hongye%3BBadano%2C+Aldo&rft.aulast=Liang&rft.aufirst=Hongye&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI05%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783657&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation. AN - 70300970; 18191113 AB - Alterations in inflammatory process, neuronal death, and glia response have been observed under manipulation of interleukin-1 (IL-1) and subsequent signaling through the type 1 IL-1 receptor (IL-1R1). To investigate the influence of IL-1R1 activation in the pathophysiology of a chemical-induced injury to the murine hippocampus, we examined the level and pattern of neuronal death and neuroinflammation in male weanling mice exposed to trimethyltin hydroxide (2.0 mg TMT/kg, i.p.). Dentate granule cell death occurred at 6 h post-TMT as detected by active caspase 3 immunostaining and presence of lectin positive microglia. The severity of neuronal death and microglia response increased by 12-24 h with elevations in mRNA levels for TNFalpha and IL-1alpha. In IL-1R1 null (IL-1R1-/-) mice, the pattern and severity of neuronal death at 24 or 72 h post-TMT was similar as compared to wildtype (WT) mice. In both groups, mRNA levels for TNFalpha and MIP-1alpha were elevated, no significant change was seen in either IL-1alpha or IL-1beta, and the early activation of microglia, including their ability to progress to a phagocytic phenotype, was maintained. Compared to WT mice, IL-1R1-/- mice displayed a limited glial fibrillary acidic protein (GFAP) astrocytic response, as well as a preferential induction in mRNA levels of Fas signaling components. Cumulatively, these results indicate that IL-1R1 activation is not necessary for TMT-induced death of dentate granule neurons or local activation of microglia; however, IL-1R1 signaling is involved in mediating the structural response of astrocytes to injury and may regulate apoptotic mechanisms via Fas signaling components. JF - Brain research AU - Harry, G Jean AU - Funk, Jason A AU - Lefebvre d'Hellencourt, Christian AU - McPherson, Christopher A AU - Aoyama, Mineyoshi AD - Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. harry@niehs.nih.gov Y1 - 2008/02/15/ PY - 2008 DA - 2008 Feb 15 SP - 8 EP - 20 VL - 1194 SN - 0006-8993, 0006-8993 KW - Apoptosis Regulatory Proteins KW - 0 KW - Glial Fibrillary Acidic Protein KW - Interleukin-1alpha KW - Lectins KW - Myd88 protein, mouse KW - Myeloid Differentiation Factor 88 KW - Receptors, Interleukin-1 KW - Trimethyltin Compounds KW - Tumor Necrosis Factor-alpha KW - trimethyltin hydroxide KW - 56-24-6 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Myeloid Differentiation Factor 88 -- metabolism KW - Animals KW - Cell Death -- physiology KW - Apoptosis Regulatory Proteins -- genetics KW - Trimethyltin Compounds -- pharmacology KW - Random Allocation KW - Interleukin-1alpha -- metabolism KW - Glial Fibrillary Acidic Protein -- metabolism KW - Mice KW - Cell Death -- drug effects KW - Tumor Necrosis Factor-alpha -- genetics KW - Mice, Knockout KW - Gene Expression Regulation -- genetics KW - Apoptosis Regulatory Proteins -- metabolism KW - Mice, Inbred C57BL KW - Gene Expression Regulation -- drug effects KW - Tumor Necrosis Factor-alpha -- metabolism KW - Time Factors KW - Male KW - Lectins -- metabolism KW - Caspase 3 -- metabolism KW - Interleukin-1alpha -- genetics KW - Receptors, Interleukin-1 -- deficiency KW - Microglia -- physiology KW - Neurons -- drug effects KW - Neurons -- physiology KW - Dentate Gyrus -- cytology KW - Receptors, Interleukin-1 -- physiology KW - Microglia -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70300970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=The+type+1+interleukin+1+receptor+is+not+required+for+the+death+of+murine+hippocampal+dentate+granule+cells+and+microglia+activation.&rft.au=Harry%2C+G+Jean%3BFunk%2C+Jason+A%3BLefebvre+d%27Hellencourt%2C+Christian%3BMcPherson%2C+Christopher+A%3BAoyama%2C+Mineyoshi&rft.aulast=Harry&rft.aufirst=G&rft.date=2008-02-15&rft.volume=1194&rft.issue=&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2007.11.076 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-30 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Growth Differ. 1999 Dec;10(12):797-804 [10616904] Brain Res. 1995 Feb 13;671(2):261-6 [7743213] Neuroimmunomodulation. 2000;7(3):153-9 [10754403] Cytokine. 2000 May;12(5):423-31 [10857755] J Neurosci. 2000 Sep 15;20(18):6811-9 [10995825] Trends Neurosci. 2000 Dec;23(12):618-25 [11137152] Exp Neurol. 2001 Mar;168(1):23-31 [11170718] J Neurosci. 2001 Aug 1;21(15):5528-34 [11466424] Brain Res. 2001 Sep 7;912(2):116-27 [11532427] Nat Rev Neurosci. 2001 Oct;2(10):734-44 [11584311] J Neurosci Res. 2001 Nov 1;66(3):464-74 [11746364] J Neurosci. 2002 Jan 1;22(1):38-43 [11756486] J Neurosci. 1995 May;15(5 Pt 1):3468-74 [7538561] J Biol Chem. 1995 Jun 9;270(23):13757-65 [7775431] Am J Pathol. 1995 Nov;147(5):1477-86 [7485410] J Comp Neurol. 1995 Oct 30;361(4):681-98 [8576422] Blood. 1996 Mar 15;87(6):2095-147 [8630372] Neuroimmunomodulation. 1995 May-Jun;2(3):121-33 [8646560] FEBS Lett. 1996 Oct 7;394(3):273-8 [8830657] J Cereb Blood Flow Metab. 1996 Nov;16(6):1137-42 [8898685] Neuroreport. 1996 Sep 2;7(13):2181-5 [8930985] Biochem Biophys Res Commun. 1997 May 8;234(1):211-5 [9168991] Immunity. 1997 Dec;7(6):837-47 [9430229] J Neurosci Res. 1998 Apr 1;52(1):7-16 [9556025] J Leukoc Biol. 1998 Jun;63(6):650-7 [9620655] J Neurochem. 1998 Oct;71(4):1577-87 [9751191] J Cereb Blood Flow Metab. 1999 Jan;19(1):87-98 [9886359] J Neurochem. 1999 Apr;72(4):1353-61 [10098836] Neurosci Res. 1999 Apr;33(4):251-60 [10401977] Neuroscience. 1999;93(3):915-30 [10473257] Exp Neurol. 2005 Jan;191(1):145-53 [15589521] J Cereb Blood Flow Metab. 2005 Jan;25(1):17-29 [15678109] Neurotox Res. 2005;7(3):183-92 [15897153] Nat Rev Immunol. 2005 Aug;5(8):629-40 [16034365] Glia. 2006 Apr 1;53(5):551-6 [16374779] Am J Clin Nutr. 2006 Feb;83(2):470S-474S [16470015] J Neuroimmunol. 2006 Jun;175(1-2):97-106 [16626814] Int J Mol Med. 2006 Jul;18(1):33-9 [16786153] J Neurochem. 2006 Jul;98(1):258-66 [16805812] Stroke. 2005 Oct;36(10):2226-31 [16179572] Neuroscience. 2006;137(1):301-8 [16289587] Methods. 2001 Dec;25(4):402-8 [11846609] Br J Pharmacol. 2002 May;136(2):312-20 [12010781] Toxicol Appl Pharmacol. 2002 May 1;180(3):205-18 [12009860] J Neurosci. 2002 Jul 15;22(14):6071-82 [12122068] J Neuroimmunol. 2002 Nov;132(1-2):60-5 [12417434] Neuroimmunomodulation. 2002-2003;10(4):199-207 [12584407] Brain Behav Immun. 2003 Jun;17(3):152-7 [12706413] Neurotoxicology. 2003 Jun;24(3):343-56 [12782100] J Neuroimmunol. 2003 Aug;141(1-2):141-9 [12965265] J Neurosci. 2003 Sep 24;23(25):8692-700 [14507968] Adv Exp Med Biol. 2004;548:57-68 [15250585] J Neurosci. 1988 Jul;8(7):2485-90 [2470873] Proc Natl Acad Sci U S A. 1989 Oct;86(19):7611-5 [2529544] J Neurochem. 1992 Feb;58(2):454-60 [1729393] J Neurosci. 1992 Mar;12(3):1101-14 [1532025] J Cell Biol. 1992 Apr;117(2):395-400 [1560032] Brain Res. 1993 Nov 19;628(1-2):227-34 [8313151] Neuroscience. 1994 Feb;58(3):563-72 [8170537] Immunol Today. 1994 Dec;15(12):562-6 [7848516] Neurosci Lett. 1994 Oct 24;180(2):147-50 [7700568] Science. 1995 Apr 21;268(5209):411-5 [7536343] J Neuroimmunol. 1999 Dec;100(1-2):203-15 [10695731] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2007.11.076 ER - TY - CPAPER T1 - Characterization of Proteins Associated with Cardiac Myofibrils using a Proteomic Approach T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40726987; 4766127 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Edmondson, Ricky D AU - Jones, Richard C AU - Gomes, Aldrin V Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Proteomics KW - Myofibrils KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40726987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Characterization+of+Proteins+Associated+with+Cardiac+Myofibrils+using+a+Proteomic+Approach&rft.au=Edmondson%2C+Ricky+D%3BJones%2C+Richard+C%3BGomes%2C+Aldrin+V&rft.aulast=Edmondson&rft.aufirst=Ricky&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Associations between Outpatient and Inpatient Service Use among Persons with HIV Infection: A Positive or Negative Relationship? AN - 839570535; 201101284 AB - Objective. To examine the prospective association between frequency of outpatient visits and subsequent inpatient admissions. Data Sources. Medical record data on 13,942 patients with HIV infection seen in 10 HIV specialty care sites across the United States. Study Design. This observational study followed a cohort of HIV-infected patients who were in care in the first half of 2001. Numbers of inpatient admissions and outpatient visits were calculated for each patient for each 3-month period, from 2001 through 2004. Analysis. Negative binomial and logistic regression analyses using random-effects models examined the effects of inpatient admissions and outpatient visits in the previous period on inpatient and outpatient service utilization, controlling for background characteristics and HIV disease stage. Results. For 3-month periods, between 5 and 9 percent of patients had an inpatient admission. The linear association between number of outpatient visits and any inpatient admission in the subsequent period was positive (adjusted odds ratio=1.05; 95 percent confidence interval [CI]=1.04, 1.06). However, patients with zero prior outpatient visits had significantly greater admission rates than those with one prior visit. Hospitalization rates were also higher among those with a prior hospitalization and those with more advanced HIV disease. Conclusions. These results suggest a J-shaped relationship between outpatient use and inpatient use among persons with HIV disease. Those in worse health have greater utilization of both inpatient and outpatient care. However, having no outpatient visits may also increase the likelihood of subsequent hospitalization. Although outpatient care cannot be justified as a cost-saving mechanism, maintaining regular clinical monitoring of patients is important. Adapted from the source document. JF - Health Services Research AU - Fleishman, John A AU - Moore, Richard D AU - Conviser, Richard AU - Lawrence, Perrin B AU - Korthuis, P Todd AU - Gebo, Kelly A AD - Center for Cost and Financing Studies, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 76 EP - 95 PB - Blackwell Publishers, Oxford UK VL - 43 IS - 1p1 SN - 0017-9124, 0017-9124 KW - HIV infection KW - inpatient service use KW - outpatient service use KW - Hospitalization KW - Background characteristics KW - Infection KW - HIV KW - Confidence intervals KW - Outpatient treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839570535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Associations+between+Outpatient+and+Inpatient+Service+Use+among+Persons+with+HIV+Infection%3A+A+Positive+or+Negative+Relationship%3F&rft.au=Fleishman%2C+John+A%3BMoore%2C+Richard+D%3BConviser%2C+Richard%3BLawrence%2C+Perrin+B%3BKorthuis%2C+P+Todd%3BGebo%2C+Kelly+A&rft.aulast=Fleishman&rft.aufirst=John&rft.date=2008-02-01&rft.volume=43&rft.issue=1p1&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2007.00750.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Hospitalization; HIV; Outpatient treatment; Infection; Confidence intervals; Background characteristics DO - http://dx.doi.org/10.1111/j.1475-6773.2007.00750.x ER - TY - JOUR T1 - Respiratory toxicologic pathology of inhaled diacetyl in sprague-dawley rats. AN - 70719926; 18474946 AB - Inhalation of butter flavoring vapors by food manufacturing workers causes an emerging lung disease clinically resembling bronchiolitis obliterans. Diacetyl, an alpha-diketone, is a major component of these vapors. In rats, we investigated the toxicity of inhaled diacetyl at concentrations of up to 365 ppm (time weighted average), either as six-hour continuous exposures or as four brief, intense exposures over six hours. A separate group inhaled a single pulse of ~1800 ppm diacetyl (92.9 ppm six-hour average). Rats were necropsied 18 to 20 hours after exposure. Diacetyl inhalation caused epithelial necrosis and suppurative to fibrinosuppurative inflammation in the nose, larynx, trachea, and bronchi. Bronchi were affected at diacetyl concentrations of 294.6 ppm or greater; the trachea and larynx were affected at diacetyl concentrations of 224 ppm or greater. Both pulsed and continuous exposure patterns caused epithelial injury. The nose had the greatest sensitivity to diacetyl. Ultrastructural changes in the tracheal epithelium included whorling and dilation of the rough endoplasmic reticulum, chromatin clumping beneath the nuclear membrane, vacuolation, increased inter-cellular space and foci of denuded basement membrane. Edema and hemorrhage extended into the lamina propria. These findings are consistent with the conclusion that inhaled diacetyl is a respiratory hazard. JF - Toxicologic pathology AU - Hubbs, Ann F AU - Goldsmith, William T AU - Kashon, Michael L AU - Frazer, David AU - Mercer, Robert R AU - Battelli, Lori A AU - Kullman, Gregory J AU - Schwegler-Berry, Diane AU - Friend, Sherri AU - Castranova, Vincent AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. ahubbs@cdc.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 330 EP - 344 VL - 36 IS - 2 KW - Air Pollutants, Occupational KW - 0 KW - Diacetyl KW - K324J5K4HM KW - Index Medicus KW - Animals KW - Basement Membrane -- ultrastructure KW - Neutrophils -- pathology KW - Dose-Response Relationship, Drug KW - Basement Membrane -- drug effects KW - Bronchi -- drug effects KW - Trachea -- ultrastructure KW - Rats KW - Neutrophils -- drug effects KW - Microscopy, Electron, Transmission KW - Rats, Sprague-Dawley KW - Necrosis KW - Bronchi -- ultrastructure KW - Atmosphere Exposure Chambers KW - Trachea -- drug effects KW - Administration, Inhalation KW - Male KW - Microscopy, Electron, Scanning KW - Diacetyl -- toxicity KW - Respiratory Tract Diseases -- chemically induced KW - Respiratory Mucosa -- drug effects KW - Respiratory Tract Diseases -- pathology KW - Air Pollutants, Occupational -- toxicity KW - Respiratory Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70719926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Respiratory+toxicologic+pathology+of+inhaled+diacetyl+in+sprague-dawley+rats.&rft.au=Hubbs%2C+Ann+F%3BGoldsmith%2C+William+T%3BKashon%2C+Michael+L%3BFrazer%2C+David%3BMercer%2C+Robert+R%3BBattelli%2C+Lori+A%3BKullman%2C+Gregory+J%3BSchwegler-Berry%2C+Diane%3BFriend%2C+Sherri%3BCastranova%2C+Vincent&rft.aulast=Hubbs&rft.aufirst=Ann&rft.date=2008-02-01&rft.volume=36&rft.issue=2&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623307312694 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623307312694 ER - TY - JOUR T1 - Isoproterenol-induced cardiotoxicity in sprague-dawley rats: correlation of reversible and irreversible myocardial injury with release of cardiac troponin T and roles of iNOS in myocardial injury. AN - 70719837; 18349426 AB - The present study was undertaken to characterize myocardial lesions in the rat induced by low doses of isoproterenol (Iso) and to correlate lesion severity with release of cardiac troponin T (cTnT) and changes in myocyte iNOS expression. Two types of cardiac injury patterns were observed. A Type I response, noted 3 or 6 hours postdosing with 8, 16, 32, or 64 mug/kg Iso, included potential reversible myocardial alterations associated with slight increases in serum cTnT (< 0.3 ng/mL) and a slight reduction in myocyte cTnT immunoreactivity. The second type of response noted 3, 6, 12, 24 or 48 hours postdosing with 125, 250, or 500 mug/kg Iso consisted of irreversible myocyte alterations, together with significant increases in serum cTnT (3-14 ng/mL) and a marked reduction of cTnT immunoreactivity. By 48 hours the hearts of rats dosed with 125-500 mug/kg Iso had developed interstitial fibrosis, and serum cTnT had declined to near control levels (0.06-0.18 ng/mL). Increases in iNOS immunoreactivity correlated with the lesion severity. These findings suggest that low doses of Iso exert complex effects on the myocardium and that the generation of NO through increased expression of iNOS could be an important factor in the pathogenesis of myocyte injury. JF - Toxicologic pathology AU - Zhang, Jun AU - Knapton, Alan AU - Lipshultz, Steven E AU - Weaver, James L AU - Herman, Eugene H AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. jun.zhang@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 277 EP - 278 VL - 36 IS - 2 KW - Adrenergic beta-Antagonists KW - 0 KW - Troponin T KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Nos2 protein, rat KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Rats KW - Myocytes, Cardiac -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Cell Count KW - Myocardium -- pathology KW - Dose-Response Relationship, Drug KW - Apoptosis -- drug effects KW - Injections, Subcutaneous KW - Disease Models, Animal KW - Myocytes, Cardiac -- pathology KW - Myocardium -- metabolism KW - Male KW - Immunoenzyme Techniques KW - Myocytes, Cardiac -- metabolism KW - Myocardial Infarction -- pathology KW - Myocardial Infarction -- blood KW - Troponin T -- blood KW - Adrenergic beta-Antagonists -- toxicity KW - Nitric Oxide Synthase Type II -- blood KW - Heart -- drug effects KW - Isoproterenol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70719837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Isoproterenol-induced+cardiotoxicity+in+sprague-dawley+rats%3A+correlation+of+reversible+and+irreversible+myocardial+injury+with+release+of+cardiac+troponin+T+and+roles+of+iNOS+in+myocardial+injury.&rft.au=Zhang%2C+Jun%3BKnapton%2C+Alan%3BLipshultz%2C+Steven+E%3BWeaver%2C+James+L%3BHerman%2C+Eugene+H&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2008-02-01&rft.volume=36&rft.issue=2&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623307313010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623307313010 ER - TY - JOUR T1 - Linkage of the National Health Interview Survey to air quality data. AN - 70418291; 18351156 AB - This report describes the linkage between the National Health Interview Survey (NHIS) and air monitoring data from the U.S. Environmental Protection Agency (EPA). There have been few linkages of these data sources, partly because of restrictions on releasing geographic detail from NHIS on public-use files in order to protect participant confidentiality. Pollution exposures for NHIS respondents were calculated by averaging the annual average exposure estimates from EPA air monitors both within 5, 10, 15, and 20 miles of the respondent's block-group location (which is available on restricted NHIS data files) and by county of residence. The 1987-2005 linked data files--referred to as NHIS-EPAAnnualAir--were used to describe the percentage of NHIS respondents linked and the median exposures by linkage method, survey year, and pollutant. Using the 2005 NHIS-EPAAnnualAir data file, the percentage linked and median exposure were described by respondent characteristics, linkage method, and pollutant. Many decisions were made to define pollution exposures for NHIS respondents, including monitor selection, location assignment for NHIS respondents, and geographic linkage criteria. Geographic linkage criteria for assigning area-level exposure estimates affected the percentage and composition of respondents included in the resulting linked sample. Median exposure estimates, however, were similar among geographic linkage methods. NHIS-EPAAnnualAir data files for 1985 through 2005 are currently available to users in the NCHS Research Data Center. JF - Vital and health statistics. Series 2, Data evaluation and methods research AU - Parker, Jennifer D AU - Kravets, Nataliya AU - Woodruff, Tracey J AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Office of Analysis and Epidemiology, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 1 EP - 24 IS - 145 SN - 0083-2057, 0083-2057 KW - Index Medicus KW - United States KW - United States Environmental Protection Agency KW - Humans KW - Environmental Exposure -- analysis KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Air Pollution -- analysis KW - Health Surveys KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70418291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vital+and+health+statistics.+Series+2%2C+Data+evaluation+and+methods+research&rft.atitle=Linkage+of+the+National+Health+Interview+Survey+to+air+quality+data.&rft.au=Parker%2C+Jennifer+D%3BKravets%2C+Nataliya%3BWoodruff%2C+Tracey+J&rft.aulast=Parker&rft.aufirst=Jennifer&rft.date=2008-02-01&rft.volume=&rft.issue=145&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Vital+and+health+statistics.+Series+2%2C+Data+evaluation+and+methods+research&rft.issn=00832057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Low frequency magnetic emissions and resulting induced voltages in a pacemaker by iPod portable music players. AN - 70366309; 18241327 AB - Recently, malfunctioning of a cardiac pacemaker electromagnetic, caused by electromagnetic interference (EMI) by fields emitted by personal portable music players was highly publicized around the world. A clinical study of one patient was performed and two types of interference were observed when the clinicians placed a pacemaker programming head and an iPod were placed adjacent to the patient's implanted pacemaker. The authors concluded that "Warning labels may be needed to avoid close contact between pacemakers and iPods". We performed an in-vitro study to evaluate these claims of EMI and present our findings of no-effects" in this paper. We performed in-vitro evaluations of the low frequency magnetic field emissions from various models of the Apple Inc. iPod music player. We measured magnetic field emissions with a 3-coil sensor (diameter of 3.5 cm) placed within 1 cm of the surface of the player. Highly localized fields were observed (only existing in a one square cm area). We also measured the voltages induced inside an 'instrumented-can' pacemaker with two standard unipolar leads. Each iPod was placed in the air, 2.7 cm above the pacemaker case. The pacemaker case and leads were placed in a saline filled torso simulator per pacemaker electromagnetic compatibility standard ANSI/AAMI PC69:2000. Voltages inside the can were measured. Emissions were strongest ( approximately 0.2 muT pp) near a few localized points on the cases of the two iPods with hard drives. Emissions consisted of 100 kHz sinusoidal signal with lower frequency (20 msec wide) pulsed amplitude modulation. Voltages induced in the iPods were below the noise level of our instruments (0.5 mV pp in the 0 - 1 kHz band or 2 mV pp in the 0 - 5 MHz bandwidth. Our measurements of the magnitude and the spatial distribution of low frequency magnetic flux density emissions by 4 different models of iPod portable music players. Levels of less than 0.2 muT exist very close (1 cm) from the case. The measured voltages induced inside an 'instrumented-can' pacemaker were below the noise level of our instruments. Based on the observations of our in-vitro study we conclude that no interference effects can occur in pacemakers exposed to the iPod devices we tested. JF - Biomedical engineering online AU - Bassen, Howard AD - U.S. Food and Drug Administration, Silver Spring, MD 20993, USA. howard.bassen@fda.hhs.gov Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 7 VL - 7 KW - Index Medicus KW - Radiation Dosage KW - Equipment Design KW - Equipment Failure Analysis KW - Equipment Failure KW - Pacemaker, Artificial KW - Electromagnetic Fields KW - Artifacts KW - Radiometry KW - Household Articles -- instrumentation KW - Music KW - Equipment Safety -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70366309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+engineering+online&rft.atitle=Low+frequency+magnetic+emissions+and+resulting+induced+voltages+in+a+pacemaker+by+iPod+portable+music+players.&rft.au=Bassen%2C+Howard&rft.aulast=Bassen&rft.aufirst=Howard&rft.date=2008-02-01&rft.volume=7&rft.issue=&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Biomedical+engineering+online&rft.issn=1475-925X&rft_id=info:doi/10.1186%2F1475-925X-7-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-03-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Heart Rhythm. 2007 Jun;4(6):781-4 [17556203] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1475-925X-7-7 ER - TY - JOUR T1 - FDA drug approval summary: alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia. AN - 70349778; 18305062 AB - On September 19, 2007, the U.S. Food and Drug Administration granted regular approval and expanded labeling for alemtuzumab (Campath); Genzyme Corporation, Cambridge, MA) as single-agent treatment for B-cell chronic lymphocytic leukemia (B-CLL). Alemtuzumab was initially approved in 2001 under accelerated approval regulations. Conversion to regular approval was based on a single study submitted to verify clinical benefit. Efficacy and safety were demonstrated in an open-label, international, multicenter, randomized trial of 297 patients with previously untreated, Rai stage I-IV B-CLL experiencing progression of their disease. Patients were randomized to either alemtuzumab, 30 mg i.v. over 2 hours three times per week on alternate days for a maximum of 12 weeks, or chlorambucil, 40 mg/m(2) orally every 28 days for a maximum of 12 months. The progression-free survival time, the primary study endpoint, was significantly longer in the alemtuzumab arm than in the chlorambucil arm. Both the overall and complete response rates were also significantly higher in the alemtuzumab arm. No differences in survival were observed. There were no new safety signals identified in patients receiving alemtuzumab. The most serious, and sometimes fatal, toxicities of alemtuzumab are cytopenias, infusion reactions, and infections. JF - The oncologist AU - Demko, Suzanne AU - Summers, Jeffrey AU - Keegan, Patricia AU - Pazdur, Richard AD - P.A.-C., U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. suzanne.demko@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 167 EP - 174 VL - 13 IS - 2 SN - 1083-7159, 1083-7159 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antibodies, Neoplasm KW - Antineoplastic Agents KW - Antineoplastic Agents, Alkylating KW - Chlorambucil KW - 18D0SL7309 KW - alemtuzumab KW - 3A189DH42V KW - Index Medicus KW - United States KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - United States Food and Drug Administration KW - Humans KW - Drug Approval KW - Disease Progression KW - Aged KW - Middle Aged KW - Europe KW - Chlorambucil -- therapeutic use KW - Male KW - Female KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Antibodies, Neoplasm -- adverse effects KW - Antibodies, Neoplasm -- therapeutic use KW - Antibodies, Neoplasm -- administration & dosage KW - Antibodies, Monoclonal -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Antibodies, Monoclonal -- administration & dosage KW - Antineoplastic Agents -- adverse effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70349778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+drug+approval+summary%3A+alemtuzumab+as+single-agent+treatment+for+B-cell+chronic+lymphocytic+leukemia.&rft.au=Demko%2C+Suzanne%3BSummers%2C+Jeffrey%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Demko&rft.aufirst=Suzanne&rft.date=2008-02-01&rft.volume=13&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/10.1634%2Ftheoncologist.2007-0218 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-15 N1 - Date created - 2008-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2007-0218 ER - TY - JOUR T1 - Drug release kinetics from stent device-based delivery systems. AN - 70316649; 18287878 AB - In an effort to overcome the limitations of balloon-expandible intravascular metal stent-induced neointimal formation, drug-coated stent devices have been developed. The stent platform allows the local delivery of drugs to an injury site, thereby reducing the amount of drug exposure to the systemic circulation and other organs. The drug carrier matrix allows the release of the drug in a diffusion-controlled manner over an extended time period after the stent implant. The drugs are chosen such that the complex cascade of events that occurs after stent implantation that leads to smooth muscle cell proliferation and migration towards the intima are inhibited. The success of an antirestenotic drug therapy from a drug-coated stent is dependent, at least partially, on the extent of drug elution from the stent, the duration and rate of release, and accumulation of drug in the arterial wall in such a way that it covers the initiation and progression of vessel wall remodeling. The local vascular drug concentrations achieved are directly correlated with the biological effects and local vascular toxicity, and there is therefore a challenge in finding an optimum dose of drug to be delivered to tissues (ie, one that has the desired therapeutic effect without local adverse effects). There is increased focus on optimization of various factors that affect drug release from the stent system, including the physicochemical properties of the drugs, carrier vehicle formulation, and profile of elution kinetics. This review highlights the various factors involved in drug release kinetics, local vascular toxicity, carrier vehicle matrix, tissue deposition, and distribution through the arterial wall from stent-based drug delivery systems. JF - Journal of cardiovascular pharmacology AU - Tesfamariam, Belay AD - Division of Cardiovascular and Renal, Center for Drug Evaluation and Research, Food & Drug Administration, Silver Spring, Maryland 20993-0002, USA. belay.tesfamariam@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 118 EP - 125 VL - 51 IS - 2 SN - 0160-2446, 0160-2446 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Drug Delivery Systems KW - Animals KW - Equipment Design KW - Humans KW - Coronary Restenosis -- prevention & control KW - Pharmacokinetics KW - Pharmaceutical Preparations -- administration & dosage KW - Pharmaceutical Preparations -- metabolism KW - Drug-Eluting Stents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70316649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology&rft.atitle=Drug+release+kinetics+from+stent+device-based+delivery+systems.&rft.au=Tesfamariam%2C+Belay&rft.aulast=Tesfamariam&rft.aufirst=Belay&rft.date=2008-02-01&rft.volume=51&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology&rft.issn=01602446&rft_id=info:doi/10.1097%2FFJC.0b013e318158540f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-09 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/FJC.0b013e318158540f ER - TY - JOUR T1 - Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells. AN - 70316193; 18273910 AB - The antioxidant-activated transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the induction of cytoprotective genes against chemical toxicity and oxidative injuries. The role of phosphorylation in Nrf2 activation has been suggested but remains elusive. We report that phenolic antioxidant/pro-oxidant tert-butylhydroquinone (tBHQ) induced two forms of the Nrf2 protein in neuroblastoma cells (IMR-32), which migrated as distinctive bands on SDS-PAGE. In vitro treatment with lambda phosphatase eliminated the slower migrating form and increased the amount of the faster migrating form of Nrf2. In vivo (32)Pi-phosphorylation resulted in (32)Pi-labeling of the Nrf2 protein in the presence of tBHQ that can be dephosphorylated by lambda phosphotase, indicating that the slower migrating form is a phosphorylated Nrf2 protein and the faster form an unphosphorylated Nrf2. Unphosphorylated Nrf2 predominated in the cytoplasm, whereas the phosphorylated form preferentially localized in the nucleus. Nuclear Nrf2 can be dephosphorylated by lambda phosphotase in vitro and be converted to the faster migrating form, implicating phosphorylation of Nrf2 in the cytoplasmic-nuclear translocation of the protein. Deletional analyses from both the carboxyl- and amino-ends revealed the transcription activation (TA) domains Neh4 (Nrf2-ECH homology 4) and Neh5 (Nrf2-ECH homology 5) as a major region necessary for the phosphorylation. The TA domains are characterized by the presence of multiple phosphorylation sites of casein kinase 2 (CK2). Moreover, CK2 phosphorylated the TA domains in vitro. Treatment with CK2 inhibitor 2-dimethylamino-4,5,6,7,-tetrabromo-1H-benzimidazole (DMAT) blocked the induction of endogenous target genes of Nrf2 in cells and inhibited the TA activities of both the full length and the TA domains of Nrf2 to a large extent. Finally, phosphorylation of the TA domains correlated with the nuclear translocation of Nrf2 that was inhibited by DMAT in a concentration-dependent manner. The findings demonstrated that phosphorylation of Nrf2 at the TA domains by CK2 is an integral component of Nrf2 activation necessary for the nuclear localization and transcription activation function of Nrf2 in neuroblastoma cells. (c) 2008 Wiley Periodicals, Inc. JF - Journal of biochemical and molecular toxicology AU - Apopa, Patrick L AU - He, Xiaoqing AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 63 EP - 76 VL - 22 IS - 1 KW - 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole KW - 0 KW - Benzimidazoles KW - NF-E2-Related Factor 2 KW - Protein Isoforms KW - Recombinant Proteins KW - Casein Kinase II KW - EC 2.7.11.1 KW - Index Medicus KW - Substrate Specificity -- drug effects KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Protein Transport -- drug effects KW - Benzimidazoles -- pharmacology KW - Humans KW - Protein Isoforms -- metabolism KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Mice KW - Phosphorylation -- drug effects KW - Conserved Sequence KW - Protein Isoforms -- chemistry KW - Recombinant Proteins -- metabolism KW - Molecular Sequence Data KW - Protein Structure, Tertiary KW - Sequence Deletion KW - Neuroblastoma -- pathology KW - Casein Kinase II -- metabolism KW - Cell Nucleus -- metabolism KW - Transcriptional Activation -- genetics KW - Neuroblastoma -- enzymology KW - NF-E2-Related Factor 2 -- chemistry KW - Cell Nucleus -- drug effects KW - Casein Kinase II -- antagonists & inhibitors KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70316193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biochemical+and+molecular+toxicology&rft.atitle=Phosphorylation+of+Nrf2+in+the+transcription+activation+domain+by+casein+kinase+2+%28CK2%29+is+critical+for+the+nuclear+translocation+and+transcription+activation+function+of+Nrf2+in+IMR-32+neuroblastoma+cells.&rft.au=Apopa%2C+Patrick+L%3BHe%2C+Xiaoqing%3BMa%2C+Qiang&rft.aulast=Apopa&rft.aufirst=Patrick&rft.date=2008-02-01&rft.volume=22&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Journal+of+biochemical+and+molecular+toxicology&rft.issn=1099-0461&rft_id=info:doi/10.1002%2Fjbt.20212 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-24 N1 - Date created - 2008-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jbt.20212 ER - TY - JOUR T1 - Mycotoxins in botanicals and dried fruits: a review. AN - 70310934; 18286408 AB - Botanicals are used in many countries for medicinal and general health-promoting purposes. Numerous natural occurrences of mycotoxins in botanicals and dried fruits have been reported. Aflatoxins or ochratoxin A (OTA) have been found in botanicals such as ginseng, ginger, liquorice, turmeric, and kava-kava in the USA, Spain, Argentina, India, and some other countries, while fumonisins have been found in medicinal wild plants in South Africa and in herbal tea and medicinal plants in Turkey. Zearalenone was identified in ginseng root. Dried fruits can be contaminated with aflatoxins, OTA, kojic acid, and, occasionally, with patulin or zearalenone. One main area of concern is aflatoxins in dried figs; bright greenish yellow fluorescence under ultraviolet light is associated with aflatoxin contamination. OTA in dried vine fruits (raisins, sultanas, and currants) is another concern. There are also reports of aflatoxins in raisins and OTA in dried figs, apricots, dried plums (prunes), dates, and quince. Maximum permitted levels in the European Union include 4 microg kg(-1) for total aflatoxins in dried fruit intended for direct consumption and 10 microg kg(-1) for OTA in dried vine fruit. This review discusses the occurrence of mycotoxins in botanicals and dried fruits and analytical issues such as sampling, sample preparation, and methods for analysis. Fungal contamination of these products, the influence of sorting, storage, and processing, and prevention are also considered. JF - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment AU - Trucksess, M W AU - Scott, P M AD - Food and Drug Administration, College Park, MD 20740, USA. mary.trucksess@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 181 EP - 192 VL - 25 IS - 2 KW - Mycotoxins KW - 0 KW - Index Medicus KW - Food Microbiology KW - Beverages -- microbiology KW - Food Preservation KW - Fruit -- microbiology KW - Food Contamination -- analysis KW - Plants, Medicinal -- microbiology KW - Mycotoxins -- analysis KW - Fruit -- chemistry KW - Plants, Medicinal -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70310934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.atitle=Mycotoxins+in+botanicals+and+dried+fruits%3A+a+review.&rft.au=Trucksess%2C+M+W%3BScott%2C+P+M&rft.aulast=Trucksess&rft.aufirst=M&rft.date=2008-02-01&rft.volume=25&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.issn=1944-0057&rft_id=info:doi/10.1080%2F02652030701567459 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-22 N1 - Date created - 2008-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/02652030701567459 ER - TY - JOUR T1 - The IP10 (CXCL10) specific cDNA probe of the mCK-5c multiprobe RNase protection assay kit carries two nucleotide insertions that complicate the interpretation of results. AN - 70289180; 18226543 AB - RNase protection assays (RPA) employing multiprobe sets are powerful tools to simultaneously measure transcription of several different genes. We used BD Biosciences/Pharmingen's mouse chemokine probeset mCK-5c to measure chemokine gene expression in brain and spleen tissue of mice. Depending on the RPA protocol used, we observed differences in the relative amounts of transcripts for interferon-inducible protein 10 (IP-10) and T-cell activation-3 (TCA-3). Isolation and sequencing of the IP-10 specific gene from the mCK-5c probeset revealed two nucleotide insertions in the probe that are not present in the natural IP-10 cDNA. We show that these insertions cause RNase A-dependent degradation of the protected IP-10 mRNA yielding a fragment indistinguishable in size from that specific for TCA-3, thus leading to over-interpretation of TCA-3 expression as well as underestimation of IP-10 gene expression levels. JF - Cytokine AU - Sauder, Christian AU - Pedras-Vasconcelos, Joao AU - Puig, Montserrat AU - Verthelyi, Daniela AD - Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Building 29A, Room 2C-20, HFM460, 8800 Rockville Pike, Bethesda, MD 20892, USA. christian.sauder@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 182 EP - 186 VL - 41 IS - 2 KW - Chemokine CCL1 KW - 0 KW - Chemokine CXCL10 KW - Cxcl10 protein, mouse KW - Reagent Kits, Diagnostic KW - Ribonuclease, Pancreatic KW - EC 3.1.27.5 KW - Index Medicus KW - Animals KW - Base Sequence KW - Sequence Alignment KW - Spleen -- metabolism KW - Molecular Sequence Data KW - Mice KW - Brain -- metabolism KW - Mice, Inbred BALB C KW - Diagnostic Errors KW - Ribonuclease, Pancreatic -- metabolism KW - Mutagenesis, Insertional KW - Female KW - Chemokine CXCL10 -- analysis KW - Chemokine CXCL10 -- genetics KW - Chemokine CCL1 -- analysis KW - Chemokine CXCL10 -- metabolism KW - Reagent Kits, Diagnostic -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70289180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=The+IP10+%28CXCL10%29+specific+cDNA+probe+of+the+mCK-5c+multiprobe+RNase+protection+assay+kit+carries+two+nucleotide+insertions+that+complicate+the+interpretation+of+results.&rft.au=Sauder%2C+Christian%3BPedras-Vasconcelos%2C+Joao%3BPuig%2C+Montserrat%3BVerthelyi%2C+Daniela&rft.aulast=Sauder&rft.aufirst=Christian&rft.date=2008-02-01&rft.volume=41&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=1096-0023&rft_id=info:doi/10.1016%2Fj.cyto.2007.11.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2008-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cyto.2007.11.009 ER - TY - JOUR T1 - Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects. AN - 70286868; 18205997 AB - Animal and in vitro data suggest that Ginkgo biloba extract (GBE) may modulate CYP3A4 activity. As such, GBE may alter the exposure of HIV protease inhibitors metabolized by CYP3A4. It is also possible that GBE could alter protease inhibitor pharmacokinetics (PK) secondary to modulation of P-glycoprotein (P-gp). The primary objective of the study was to evaluate the effect of GBE on the exposure of lopinavir in healthy volunteers administered lopinavir/ritonavir. Secondary objectives were to compare ritonavir exposure pre- and post-GBE, and assess the effect of GBE on single doses of probe drugs midazolam and fexofenadine. This open-label study evaluated the effect of 2 weeks of standardized GBE administration on the steady-state exposure of lopinavir and ritonavir in 14 healthy volunteers administered lopinavir/ritonavir to steady-state. In addition, single oral doses of probe drugs midazolam and fexofenadine were administered prior to and after 4 weeks of GBE (following washout of lopinavir/ritonavir) to assess the influence of GBE on CYP3A and P-gp activity, respectively. Lopinavir, ritonavir and fexofenadine exposures were not significantly affected by GBE administration. However, GBE decreased midazolam AUC(0-infinity) and C(max) by 34% (p = 0.03) and 31% (p = 0.03), respectively, relative to baseline. In general, lopinavir/ritonavir and GBE were well tolerated. Abnormal laboratory results included mild elevations in hepatic enzymes, cholesterol and triglycerides, and mild-to-moderate increases in total bilirubin. Our results suggest that GBE induces CYP3A metabolism, as assessed by a decrease in midazolam concentrations. However, there was no change in the exposure of lopinavir, likely due to ritonavir's potent inhibition of CYP3A4. Thus, GBE appears unlikely to reduce the exposure of ritonavir-boosted protease inhibitors, while concentrations of unboosted protease inhibitors may be affected. Limitations to our study include the single sequence design and the evaluation of a ritonavir-boosted protease inhibitor exclusively. JF - Current medical research and opinion AU - Robertson, Sarah M AU - Davey, Richard T AU - Voell, Jocelyn AU - Formentini, Elizabeth AU - Alfaro, Raul M AU - Penzak, Scott R AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, New Hampshire Ave., Silver Spring, MD 20901, USA. sarah.robertson@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 591 EP - 599 VL - 24 IS - 2 KW - HIV Protease Inhibitors KW - 0 KW - P-Glycoprotein KW - Plant Extracts KW - Protease Inhibitors KW - Pyrimidinones KW - Lopinavir KW - 2494G1JF75 KW - Terfenadine KW - 7BA5G9Y06Q KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - fexofenadine KW - E6582LOH6V KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Ritonavir KW - O3J8G9O825 KW - Midazolam KW - R60L0SM5BC KW - Index Medicus KW - Drug Interactions KW - P-Glycoprotein -- metabolism KW - Humans KW - Adult KW - Cytochrome P-450 Enzyme System -- metabolism KW - Male KW - Female KW - Phytotherapy KW - Terfenadine -- analogs & derivatives KW - Protease Inhibitors -- pharmacokinetics KW - Ritonavir -- pharmacokinetics KW - Plant Extracts -- metabolism KW - Midazolam -- pharmacokinetics KW - Terfenadine -- pharmacokinetics KW - Pyrimidinones -- pharmacokinetics KW - HIV Protease Inhibitors -- pharmacology KW - Ginkgo biloba -- metabolism KW - Ginkgo biloba -- adverse effects KW - Plant Extracts -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70286868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+medical+research+and+opinion&rft.atitle=Effect+of+Ginkgo+biloba+extract+on+lopinavir%2C+midazolam+and+fexofenadine+pharmacokinetics+in+healthy+subjects.&rft.au=Robertson%2C+Sarah+M%3BDavey%2C+Richard+T%3BVoell%2C+Jocelyn%3BFormentini%2C+Elizabeth%3BAlfaro%2C+Raul+M%3BPenzak%2C+Scott+R&rft.aulast=Robertson&rft.aufirst=Sarah&rft.date=2008-02-01&rft.volume=24&rft.issue=2&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Current+medical+research+and+opinion&rft.issn=1473-4877&rft_id=info:doi/10.1185%2F030079908X260871 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-28 N1 - Date created - 2008-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1185/030079908X260871 ER - TY - JOUR T1 - Impact of dietary components on chicken immune system and Salmonella infection. AN - 70269829; 18251669 AB - Salmonella enterica serovars are facultative intracellular pathogens that may cause serious illness in poultry and humans. Human infection by two common serovars, Salmonella enteritidis (SE) and Salmonella typhimurium (ST) usually occurs via food-borne transmission. Consumption of raw or undercooked contaminated eggs usually causes SE infection, while ST is transmitted by contaminated chicken meat. There are several reports on dietary interventions, including fatty acid modifications, probiotic or prebiotic treatment on the immune system and/or Salmonella clearance in chickens. The aim of this review is to compile the information on the role of major dietary components on chicken immune system and Salmonella clearance. This may help design better poultry nutrition to lower Salmonella infection in chickens and, therefore, reduce human salmonellosis. JF - Expert review of anti-infective therapy AU - Babu, Uma S AU - Raybourne, Richard B AD - Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA. uma.babu@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 121 EP - 135 VL - 6 IS - 1 KW - Dietary Proteins KW - 0 KW - Index Medicus KW - Animals KW - Chickens KW - Salmonella Food Poisoning -- prevention & control KW - Humans KW - Salmonella Food Poisoning -- immunology KW - Salmonella Infections -- prevention & control KW - Probiotics -- therapeutic use KW - Salmonella Food Poisoning -- transmission KW - Salmonella Infections -- immunology KW - Dietary Proteins -- therapeutic use KW - Salmonella Infections -- transmission KW - Diet -- methods KW - Salmonella Infections, Animal -- transmission KW - Salmonella Infections, Animal -- prevention & control KW - Salmonella Infections, Animal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70269829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+anti-infective+therapy&rft.atitle=Impact+of+dietary+components+on+chicken+immune+system+and+Salmonella+infection.&rft.au=Babu%2C+Uma+S%3BRaybourne%2C+Richard+B&rft.aulast=Babu&rft.aufirst=Uma&rft.date=2008-02-01&rft.volume=6&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+anti-infective+therapy&rft.issn=1744-8336&rft_id=info:doi/10.1586%2F14787210.6.1.121 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1586/14787210.6.1.121 ER - TY - JOUR T1 - Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. AN - 70269074; 18157835 AB - Herbal products, used for centuries in Far Eastern countries, are gaining popularity in western countries. Surveys indicate that persons with chronic hepatitis C (CHC) often use herbals, especially silymarin (milk thistle extract), hoping to improve the modest response to antiviral therapy and reduce side effects. The Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, involving persons with advanced CHC, nonresponders to prior antiviral therapy but still willing to participate in long-term pegylated interferon treatment, offered the opportunity to examine the use and potential effects of silymarin. Among 1145 study participants, 56% had never taken herbals, 21% admitted past use, and 23% were using them at enrollment. Silymarin constituted 72% of 60 herbals used at enrollment. Among all participants, 67% had never used silymarin, 16% used it in the past, and 17% used it at baseline. Silymarin use varied widely among the 10 participating study centers; men were more frequent users than women, as were non-Hispanic whites than African Americans and Hispanics. Silymarin use correlated strongly with higher education. No beneficial effect of silymarin was found on serum alanine aminotransferase or hepatitis C virus (HCV) RNA levels. Univariate analysis showed significantly fewer liver-related symptoms and better quality-of-life parameters in users than nonusers, but after reanalysis adjusted for covariates of age, race, education, alcohol consumption, exercise, body mass index, and smoking, only fatigue, nausea, liver pain, anorexia, muscle and joint pain, and general health remained significantly better in silymarin users. In conclusion, silymarin users had similar alanine aminotransferase and HCV levels to those of nonusers but fewer symptoms and somewhat better quality-of-life indices. Because its use among these HALT-C participants was self-motivated and uncontrolled, however, only a well-designed prospective study can determine whether silymarin provides benefit to persons with chronic hepatitis C. JF - Hepatology (Baltimore, Md.) AU - Seeff, Leonard B AU - Curto, Teresa M AU - Szabo, Gyongyi AU - Everson, Gregory T AU - Bonkovsky, Herbert L AU - Dienstag, Jules L AU - Shiffman, Mitchell L AU - Lindsay, Karen L AU - Lok, Anna S F AU - Di Bisceglie, Adrian M AU - Lee, William M AU - Ghany, Marc G AU - HALT-C Trial Group AD - Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. seeffl@extra.niddk.nih.gov ; HALT-C Trial Group Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 605 EP - 612 VL - 47 IS - 2 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - Silymarin KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2b KW - 43K1W2T1M6 KW - interferon alfa-2a KW - 47RRR83SK7 KW - peginterferon alfa-2b KW - G8RGG88B68 KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Antiviral Agents -- therapeutic use KW - Silymarin -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Silymarin -- adverse effects KW - Polyethylene Glycols -- therapeutic use KW - Humans KW - Interviews as Topic KW - Biopsy KW - Patient Selection KW - Liver Function Tests KW - Liver Cirrhosis -- prevention & control KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - Herbal Medicine -- statistics & numerical data KW - Hepatitis C, Chronic -- therapy KW - Hepatitis C, Chronic -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70269074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Herbal+product+use+by+persons+enrolled+in+the+hepatitis+C+Antiviral+Long-Term+Treatment+Against+Cirrhosis+%28HALT-C%29+Trial.&rft.au=Seeff%2C+Leonard+B%3BCurto%2C+Teresa+M%3BSzabo%2C+Gyongyi%3BEverson%2C+Gregory+T%3BBonkovsky%2C+Herbert+L%3BDienstag%2C+Jules+L%3BShiffman%2C+Mitchell+L%3BLindsay%2C+Karen+L%3BLok%2C+Anna+S+F%3BDi+Bisceglie%2C+Adrian+M%3BLee%2C+William+M%3BGhany%2C+Marc+G%3BHALT-C+Trial+Group&rft.aulast=Seeff&rft.aufirst=Leonard&rft.date=2008-02-01&rft.volume=47&rft.issue=2&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Hepatology. 2008 Jul;48(1):345-6 [18509876] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nationwide Evaluation of X-Ray Trends. AN - 70261294; 18242533 JF - Journal of the American College of Radiology : JACR AU - Spelic, David C AD - US Food and Drug Administration, Division of Mammography Quality and Radiation Programs, 1350 Piccard Drive, HFZ-240, Rockville, MD 20850, USA. david.spelic@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 146 EP - 148 VL - 5 IS - 2 KW - Index Medicus KW - United States KW - Humans KW - Body Burden KW - Practice Patterns, Physicians' -- trends KW - Radiography -- statistics & numerical data KW - Health Care Surveys -- methods KW - Radiography -- trends KW - Practice Patterns, Physicians' -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70261294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Radiology+%3A+JACR&rft.atitle=Nationwide+Evaluation+of+X-Ray+Trends.&rft.au=Spelic%2C+David+C&rft.aulast=Spelic&rft.aufirst=David&rft.date=2008-02-01&rft.volume=5&rft.issue=2&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Radiology+%3A+JACR&rft.issn=1558-349X&rft_id=info:doi/10.1016%2Fj.jacr.2007.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2008-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jacr.2007.11.003 ER - TY - JOUR T1 - Smoking in the home and children's health. AN - 70243388; 18218804 AB - We estimate for young children the annual excess health service use, healthcare expenditures, and disability bed days for respiratory conditions associated with exposure to smoking in the home in the United States. Health service use, healthcare expenditures and disability bed days data come from the 1999 and 2001 Medical Expenditure Panel Survey (MEPS). Reported smoking in the home comes from the linked National Health Interview Survey, from which the MEPS sample is drawn. Multivariate statistical analysis controls for potential confounding factors. The sample is 2759 children aged 0-4. Smoking in the home is associated with an increase in the probability of emergency department visits for respiratory conditions by five percentage points and the probability of inpatient use for these conditions by three percentage points. There is no relation between indoor smoking by adults and either ambulatory visits or prescription drug expenditures. Overall, indoor smoking is associated with $117 in additional healthcare expenditures for respiratory conditions for each exposed child aged 0-4. Indoor smoking is also associated with an eight percentage point increase in the probability of having a bed day because of respiratory illness for children aged 1-4. Despite the significant progress made in tobacco control, many children are still exposed to secondhand smoke in their home. Reducing exposure to smoking in the home would probably reduce healthcare expenditures for respiratory conditions and improve children's health. JF - Tobacco control AU - Hill, S C AU - Liang, L AD - Center for Financing, Cost and Access Trends, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 32 EP - 37 VL - 17 IS - 1 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Asthma -- epidemiology KW - Humans KW - Infant, Newborn KW - Bronchitis -- economics KW - Child, Preschool KW - Infant KW - Bronchitis -- epidemiology KW - Risk Factors KW - United States -- epidemiology KW - Asthma -- economics KW - Female KW - Male KW - Prevalence KW - Health Services Needs and Demand -- utilization KW - Tobacco Smoke Pollution -- economics KW - Tobacco Smoke Pollution -- adverse effects KW - Emergency Service, Hospital -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70243388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+control&rft.atitle=Smoking+in+the+home+and+children%27s+health.&rft.au=Hill%2C+S+C%3BLiang%2C+L&rft.aulast=Hill&rft.aufirst=S&rft.date=2008-02-01&rft.volume=17&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Tobacco+control&rft.issn=1468-3318&rft_id=info:doi/10.1136%2Ftc.2007.020990 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-02 N1 - Date created - 2008-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/tc.2007.020990 ER - TY - JOUR T1 - Animal models for probing the developmental basis of disease and dysfunction paradigm. AN - 70237548; 18226058 AB - There is a major paradigm shift taking place in science that while simple is profound. The new paradigm suggests that susceptibility to disease is set in utero or neonatally as a result of the influences of nutrition and exposures to environmental stressors/toxicants. In utero nutrition and/or in utero or neonatal exposures to environmental toxicants alter susceptibility to disease later in life as a result of their ability to affect the programming of tissue function that occurs during development. This concept, which is still a hypothesis undergoing scientific testing and scrutiny, is called the developmental basis of health and disease. If true, then it says that the focus on disease prevention and intervention must change from the time of disease onset to perhaps decades prior: during the in utero and neonatal period. Perhaps the reason it has been so difficult to link environmental exposure to disease susceptibility is that scientists have been looking at the wrong time! Certainly, not all exposures that result in increased disease or dysfunction occur during development. This paradigm shift just suggests that this is a sensitive window of exposure that should be examined more thoroughly. This overview focuses on animal models for the assessment of this new scientific paradigm and the animal data that now supports it. JF - Basic & clinical pharmacology & toxicology AU - Heindel, Jerrold J AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. heindelj@niehs.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 76 EP - 81 VL - 102 IS - 2 KW - Environmental Pollutants KW - 0 KW - Phthalic Acids KW - Index Medicus KW - Gene Expression -- drug effects KW - Parkinson Disease, Secondary -- chemically induced KW - Animals KW - Environmental Pollutants -- toxicity KW - Adenocarcinoma -- chemically induced KW - Humans KW - Epigenesis, Genetic KW - Phthalic Acids -- toxicity KW - Pregnancy KW - Obesity -- etiology KW - Sperm Count KW - Neoplasms -- chemically induced KW - Leiomyoma -- chemically induced KW - Chronic Disease KW - Female KW - Fertility -- drug effects KW - Models, Animal KW - Maternal-Fetal Exchange KW - Environmental Exposure -- adverse effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70237548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+%26+clinical+pharmacology+%26+toxicology&rft.atitle=Animal+models+for+probing+the+developmental+basis+of+disease+and+dysfunction+paradigm.&rft.au=Heindel%2C+Jerrold+J&rft.aulast=Heindel&rft.aufirst=Jerrold&rft.date=2008-02-01&rft.volume=102&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Basic+%26+clinical+pharmacology+%26+toxicology&rft.issn=1742-7843&rft_id=info:doi/10.1111%2Fj.1742-7843.2007.00184.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-22 N1 - Date created - 2008-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1742-7843.2007.00184.x ER - TY - JOUR T1 - Lymphogranuloma venereum proctitis in men who have sex with men is associated with anal enema use and high-risk behavior. AN - 70236483; 18091565 AB - In the industrialized world, lymphogranuloma venereum proctitis (LGVP) has been reported only in men who have sex with men. Factors responsible for the outbreak remain to be elucidated. The goal of the present work was to elucidate risk factors associated with LGVP. The study design comprised a cross-sectional study including 32 men with LGVP and 93 men without LGVP (22 with gonorrheal proctitis, 30 with a non-LGV chlamydial proctitis, and 41 with proctitis of unknown etiology). Factors associated with LGVP were analyzed by (multinomial) logistic regression. Comparing men with LGVP with men without LGVP, factors significantly associated with higher risk of LGVP in multivariate analyses were as follows: anal enema use [odds ratio (OR): 7.8, 95% confidence interval (CI): 2.6-23.2], having sex on sex parties (OR: 5.7, 95% CI: 1.5-21.8), and having sex with human immunodeficiency virus-positive partners (OR: 3.2, 95% CI: 1.1-9.3). Evaluating the 4 proctitis groups separately in a multinomial logistic regression model, similar associations between anal enema use and LGVP were found. Men with non-LGV chlamydial proctitis showed less risk behavior than men with LGVP. No substantial difference in risk behavior was found, except for attending sex parties, between men with LGVP, and gonorrheal proctitis or proctitis of unknown etiology. Apart from men with LGVP, men with gonorrheal proctitis or proctitis of unknown etiology exhibit high risk behavior. Enema use seems to play a key role in transmission of LGVP, and needs further investigation. JF - Sexually transmitted diseases AU - de Vries, Henry J C AU - van der Bij, Akke K AU - Fennema, Johan S A AU - Smit, Colette AU - de Wolf, Frank AU - Prins, Maria AU - Coutinho, Roel A AU - Morré, Servaas A AD - STI Outpatient Clinic, Cluster Infectious Diseases, Public Health Service Amsterdam. The Netherlands. h.j.devries@amc.nl Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 203 EP - 208 VL - 35 IS - 2 SN - 0148-5717, 0148-5717 KW - Index Medicus KW - Netherlands -- epidemiology KW - Cross-Sectional Studies KW - Unsafe Sex KW - Logistic Models KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Lymphogranuloma Venereum -- diagnosis KW - Homosexuality, Male KW - Risk Factors KW - Proctitis -- epidemiology KW - Enema -- adverse effects KW - Proctitis -- etiology KW - Lymphogranuloma Venereum -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70236483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+transmitted+diseases&rft.atitle=Lymphogranuloma+venereum+proctitis+in+men+who+have+sex+with+men+is+associated+with+anal+enema+use+and+high-risk+behavior.&rft.au=de+Vries%2C+Henry+J+C%3Bvan+der+Bij%2C+Akke+K%3BFennema%2C+Johan+S+A%3BSmit%2C+Colette%3Bde+Wolf%2C+Frank%3BPrins%2C+Maria%3BCoutinho%2C+Roel+A%3BMorr%C3%A9%2C+Servaas+A&rft.aulast=de+Vries&rft.aufirst=Henry+J&rft.date=2008-02-01&rft.volume=35&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Sexually+transmitted+diseases&rft.issn=01485717&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-20 N1 - Date created - 2008-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estrogen-enhanced gene expression of lipoprotein lipase in heart is antagonized by progesterone. AN - 70235410; 17974624 AB - Although estrogen has effects on the heart, little is known regarding which genes in the heart are directly responsive to estrogen. We have shown previously that lipoprotein lipase (LPL) expression was increased in female hearts compared with male hearts. To test whether LPL gene expression in heart is regulated by estrogen, we perfused mouse hearts from ovariectomized females with 100 nM 17beta-estradiol or vehicle for 2 h, after which hearts were frozen, and RNA was isolated. The SYBR green real-time PCR method was used to detect LPL gene expression. We found that addition of 17beta-estradiol to hearts from ovariectomized females resulted in a significant increase in LPL mRNA. This estrogen effect on LPL gene expression in mouse heart can be blocked by the estrogen receptor (ER) antagonist ICI 182,780 or by progesterone. We also identified a potential estrogen receptor element (ERE) enhancer sequence located in the first intron of the mouse LPL gene. The potential ERE sequence was linked to a TATA-luciferase (LUC) reporter plasmid in HeLa cells. Both ERalpha and ERbeta stimulated strong activity on the heterologous promoter reporter in Hela cells upon estrogen addition. Both ERalpha and ERbeta activities on the LPL ERE reporter were abrogated by the ER antagonist ICI 182,780. Progesterone also dose dependently inhibited the estrogen-mediated increase in LPL ERE reporter activity. These results show that heart LPL is an estrogen-responsive gene exhibiting an intronic regulatory sequence. JF - Endocrinology AU - Liu, Dianxin AU - Deschamps, Anne AU - Korach, Kenneth S AU - Murphy, Elizabeth AD - Laboratories of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 711 EP - 716 VL - 149 IS - 2 SN - 0013-7227, 0013-7227 KW - RNA, Messenger KW - 0 KW - Progesterone KW - 4G7DS2Q64Y KW - Estradiol KW - 4TI98Z838E KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Drug Interactions KW - Introns -- physiology KW - RNA, Messenger -- metabolism KW - HeLa Cells KW - Dose-Response Relationship, Drug KW - Humans KW - Mice, Inbred C57BL KW - Genes, Reporter KW - Ovariectomy KW - Mice KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Progesterone -- pharmacology KW - Lipoprotein Lipase -- genetics KW - Gene Expression Regulation, Enzymologic -- physiology KW - Myocardium -- enzymology KW - Estradiol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70235410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Estrogen-enhanced+gene+expression+of+lipoprotein+lipase+in+heart+is+antagonized+by+progesterone.&rft.au=Liu%2C+Dianxin%3BDeschamps%2C+Anne%3BKorach%2C+Kenneth+S%3BMurphy%2C+Elizabeth&rft.aulast=Liu&rft.aufirst=Dianxin&rft.date=2008-02-01&rft.volume=149&rft.issue=2&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Cell Cardiol. 2005 Feb;38(2):289-97 [15698835] Lipids. 1994 May;29(5):333-6 [8015363] J Biol Chem. 2006 Mar 31;281(13):8716-23 [16410253] FASEB J. 2006 May;20(7):926-34 [16675850] J Biol Chem. 2006 Sep 8;281(36):26683-92 [16847062] Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R800-9 [17008461] J Mol Endocrinol. 2000 Feb;24(1):145-55 [10657006] Circulation. 2001 Sep 18;104(12):1419-23 [11560859] FEBS Lett. 2001 Aug 3;502(3):103-8 [11583108] Am Heart J. 1996 Aug;132(2 Pt 1):258-62 [8701884] Circulation. 1997 Jan 7;95(1):252-64 [8994444] Circ Res. 1998 Dec 14-28;83(12):1215-23 [9851938] Mol Endocrinol. 1999 Mar;13(3):485-94 [10077005] Circulation. 2004 Nov 16;110(20):3270-5 [15533858] Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H469-76 [15374829] JAMA. 2002 Jul 17;288(3):321-33 [12117397] Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E331-9 [12388125] J Clin Invest. 2003 Feb;111(3):419-26 [12569168] Metabolism. 2003 Apr;52(4):383-8 [12701046] J Pharmacol Exp Ther. 2003 Oct;307(1):395-401 [12893838] Hypertension. 2003 Oct;42(4):781-6 [12874087] Atherosclerosis. 2003 Dec;171(2):343-50 [14644406] J Biol Chem. 2004 Jun 11;279(24):25050-7 [15028738] Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14234-9 [15375213] Biochim Biophys Acta. 1993 Aug 11;1169(2):107-25 [8343535] Circulation. 2005 Mar 29;111(12):1492-8 [15781739] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 5-HT 1B receptor-mediated serotoninergic modulation of methylphenidate-induced locomotor activation in rats. AN - 70202533; 17487226 AB - Previous studies have shown that the dopamine (DA) uptake blocker methylphenidate, a psychostimulant widely used for the treatment of attention-deficit hyperactivity disorder (ADHD), prevents the neurotoxic effects of the highly abused DA releaser methamphetamine. However, there is a lack of information about the pharmacological interactions of these two drugs at the behavioral level. When systemically administered within an interval of 2 h, previous administration of methylphenidate (10 mg/kg, intraperitoneal (i.p.)) did not modify locomotor activation induced by methamphetamine. On the other hand, previous administration of methamphetamine (1 mg/kg, i.p.) markedly potentiated methylphenidate-induced motor activation. With in vivo microdialysis experiments, methamphetamine and methylphenidate were found to increase DA extracellular levels in the nucleus accumbens (NAs). Methamphetamine, but not methylphenidate, significantly increased the extracellular levels of serotonin (5-HT) in the NAs. Methamphetamine-induced 5-HT release remained significantly elevated for more than 2 h after its administration, suggesting that the increased 5-HT could be responsible for the potentiation of methylphenidate-induced locomotor activation. In fact, previous administration of the 5-HT uptake blocker fluoxetine (10 mg/kg, i.p.) also potentiated the motor activation induced by methylphenidate. A selective 5-HT 1B receptor antagonist (GR 55562; 1 mg/kg), but not a 5-HT2 receptor antagonist (ritanserin; 2 mg/kg, i.p.), counteracted the effects of methamphetamine and fluoxetine on the motor activation induced by methylphenidate. Furthermore, a 5-HT 1B receptor agonist (CP 94253; 1-10 mg/kg, i.p.) strongly and dose-dependently potentiated methylphenidate-induced locomotor activation. The 5-HT 1B receptor-mediated modulation of methylphenidate-induced locomotor activation in rat could have implications for the treatment of ADHD. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Borycz, Janusz AU - Zapata, Agustin AU - Quiroz, César AU - Volkow, Nora D AU - Ferré, Sergi AD - Department of Health and Human Services, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 619 EP - 626 VL - 33 IS - 3 SN - 0893-133X, 0893-133X KW - CP 94253 KW - 0 KW - Central Nervous System Stimulants KW - Pyridines KW - Receptor, Serotonin, 5-HT1B KW - Serotonin Receptor Agonists KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Methylphenidate KW - 207ZZ9QZ49 KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Serotonin Receptor Agonists -- pharmacology KW - Animals KW - Fluoxetine -- pharmacology KW - Dose-Response Relationship, Drug KW - Nucleus Accumbens -- drug effects KW - Dopamine -- metabolism KW - Rats KW - Microdialysis KW - Rats, Sprague-Dawley KW - Extracellular Space -- metabolism KW - Methamphetamine -- pharmacology KW - Nucleus Accumbens -- metabolism KW - Serotonin Uptake Inhibitors -- pharmacology KW - Extracellular Space -- drug effects KW - Pyridines -- pharmacology KW - Male KW - Central Nervous System Stimulants -- pharmacology KW - Serotonin -- physiology KW - Methylphenidate -- pharmacology KW - Receptor, Serotonin, 5-HT1B -- physiology KW - Motor Activity -- drug effects KW - Serotonin -- metabolism KW - Receptor, Serotonin, 5-HT1B -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70202533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=5-HT+1B+receptor-mediated+serotoninergic+modulation+of+methylphenidate-induced+locomotor+activation+in+rats.&rft.au=Borycz%2C+Janusz%3BZapata%2C+Agustin%3BQuiroz%2C+C%C3%A9sar%3BVolkow%2C+Nora+D%3BFerr%C3%A9%2C+Sergi&rft.aulast=Borycz&rft.aufirst=Janusz&rft.date=2008-02-01&rft.volume=33&rft.issue=3&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-23 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of probiotic substances as ingredients in foods: premarket approval or "generally recognized as safe" notification. AN - 70196730; 18181714 AB - This article discusses options and examples of regulations or "generally recognized as safe" determinations that are related to microorganisms in food. A balanced picture of information about the microorganism and its characteristics is needed to make conclusions about its safety. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Mattia, Antonia AU - Merker, Robert AD - Division of Biotechnology and GRAS Notice Review, Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland 20740, USA. antonia.mattia@fda.hhs.gov Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - S115 EP - 8; discussion S144-51 VL - 46 Suppl 2 KW - Index Medicus KW - United States KW - Humans KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Legislation, Drug KW - Food Industry -- standards KW - Food Microbiology -- standards KW - Consumer Product Safety -- standards KW - Food Microbiology -- legislation & jurisprudence KW - Food Industry -- legislation & jurisprudence KW - Food, Organic -- standards KW - Probiotics -- therapeutic use KW - Consumer Product Safety -- legislation & jurisprudence KW - Probiotics -- standards KW - Legislation, Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70196730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Regulation+of+probiotic+substances+as+ingredients+in+foods%3A+premarket+approval+or+%22generally+recognized+as+safe%22+notification.&rft.au=Mattia%2C+Antonia%3BMerker%2C+Robert&rft.aulast=Mattia&rft.aufirst=Antonia&rft.date=2008-02-01&rft.volume=46+Suppl+2&rft.issue=&rft.spage=S115&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/10.1086%2F523329 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-27 N1 - Date created - 2008-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/523329 ER - TY - JOUR T1 - Structure-activity relationship analysis tools: validation and applicability in predicting carcinogens. AN - 70162949; 18023949 AB - OncoLogic and MultiCASE (MCASE) are two structure-activity relationship (SAR) analysis software programs available to screen compounds for potential carcinogenicity. Ashby-Tennant structural alerts [Ashby, J., Tennant, R.W., 1991. Definitive relationships among chemical structure, carcinogenicity, and mutagenicity for 301 chemicals tested by the US NTP. Mutat. Res. 257, 229-306] and genetic toxicity testing may also be used to assess/predict this endpoint. Six-hundred and fifty compounds tested for carcinogenicity whose results were tabulated in the Carcinogenic Potency Database (CPDB) were used to validate and compare the predictivity of OncoLogic (Version 4.1), MCASE (Version 3.1), Ashby-Tennant structural alerts, and genetic toxicity testing, individually and in combination. The sensitivity of the methods for predicting carcinogens and the specificity for predicting non-carcinogens was examined. Potent carcinogens, defined as those with TD(50) values of less than 6.25 mg/kg bw/d, were then examined separately. It is concluded that SAR analysis programs and structural alerts perform well for compounds with low human exposure levels and have the potential to supplement the results of routinely requested genetic toxicity tests in a weight-of-evidence approach in predicting carcinogenicity, although each method of analysis has limitations regarding applicability. JF - Regulatory toxicology and pharmacology : RTP AU - Mayer, J AU - Cheeseman, M A AU - Twaroski, M L AD - Food and Drug Administration, Division of Food Contact Notifications, HFS-275, 5100 Paint Branch Parkway, College Park, MD 20740, USA. julie.mayer@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 50 EP - 58 VL - 50 IS - 1 SN - 0273-2300, 0273-2300 KW - Carcinogens KW - 0 KW - Index Medicus KW - Animals KW - Mutagenicity Tests KW - Reproducibility of Results KW - Humans KW - Predictive Value of Tests KW - Structure-Activity Relationship KW - Software KW - Carcinogens -- chemistry KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70162949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Structure-activity+relationship+analysis+tools%3A+validation+and+applicability+in+predicting+carcinogens.&rft.au=Mayer%2C+J%3BCheeseman%2C+M+A%3BTwaroski%2C+M+L&rft.aulast=Mayer&rft.aufirst=J&rft.date=2008-02-01&rft.volume=50&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2007-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals. AN - 70159777; 18069108 AB - The use of transgenic rodents may overcome many limitations of traditional cancer studies. Regulatory perspectives continue to evolve as new models are developed and validated. The transgenic mouse, K6/ODC, develops epidermal tumors when exposed to genotoxic carcinogens. In this study, K6/ODC mice were evaluated for model fitness and health robustness in a 36-week study to determine oncogenic risk of residual DNA in vaccines from neoplastic cell substrates. K6/ODC and C57BL/6 mice were treated with T24-H-ras expression plasmid, carrier vector DNA, or saline topically or by subcutaneous injection. One group of K6/ODC mice received 7,12-dimethylbenz-[a]anthracene [DMBA] dermally. Only DMBA-treated mice developed papillomas by six weeks, increasing in incidence to 25 weeks. By week 11, many K6/ODC mice showed severe dehydration and dermal eczema. By week 32, (6/8) surviving K6/ODC mice showed loss of mobility and balance. Microscopic evaluation of tissues revealed dermal/sebaceous gland hyperplasia, follicular dystrophy, splenic atrophy, and amyloid deposition/neutrophilic infiltration within liver, heart, and spleen, in all K6/ODC mice. Pathology was not detected in C57BL/6 mice. Progressive adverse health, decreased survival, and failure to develop papillomas to the H-ras plasmid suggest that K6/ODC mice may be an inappropriate alternative model for detection of oncogenic DNA and pharmaceutical carcinogenicity testing. JF - Regulatory toxicology and pharmacology : RTP AU - Miller, T J AU - Honchel, R AU - Espandiari, P AU - Knapton, A AU - Zhang, J AU - Sistare, F D AU - Hanig, J P AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. terry.miller@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 87 EP - 97 VL - 50 IS - 1 SN - 0273-2300, 0273-2300 KW - Carcinogens KW - 0 KW - Keratin-6 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Carcinogens -- administration & dosage KW - Kidney -- pathology KW - 9,10-Dimethyl-1,2-benzanthracene -- administration & dosage KW - Drug-Related Side Effects and Adverse Reactions KW - Kidney -- drug effects KW - Spleen -- pathology KW - Mice KW - Sarcoma Viruses, Murine -- genetics KW - Mice, Transgenic KW - Transfection KW - Liver -- drug effects KW - Carcinogenicity Tests -- methods KW - Mice, Inbred C57BL KW - Spleen -- drug effects KW - Male KW - Ornithine Decarboxylase -- genetics KW - Keratin-6 -- genetics KW - Skin Neoplasms -- chemically induced KW - Skin Neoplasms -- pathology KW - Disease Models, Animal KW - Drug Evaluation, Preclinical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70159777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=The+utility+of+the+K6%2FODC+transgenic+mouse+as+an+alternative+short+term+dermal+model+for+carcinogenicity+testing+of+pharmaceuticals.&rft.au=Miller%2C+T+J%3BHonchel%2C+R%3BEspandiari%2C+P%3BKnapton%2C+A%3BZhang%2C+J%3BSistare%2C+F+D%3BHanig%2C+J+P&rft.aulast=Miller&rft.aufirst=T&rft.date=2008-02-01&rft.volume=50&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=02732300&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2007-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Isolation and characterization of tetracycline-resistant Citrobacter spp. from catfish. AN - 70098755; 17993380 AB - Fifty-two tetracycline-resistant Citrobacter spp. strains were isolated from farm-raised catfish. Morphological and biochemical characteristics indicated that 38 of the 52 citrobacters were Citrobacter freundii, 7 were C. amalonaticus and 7 were C. braakii. All isolates were resistant to multiple antibiotics. Polymerase chain reaction (PCR) protocols were developed to detect the presence of 3 tetracycline-resistance genes (tetA, tetB and tetG) from Citrobacter isolates. Oligonucleotide primers specifically targeting a 967-bp region of tetB successfully amplified the PCR amplicons from 3238 (85.0%) of C. freundii strains, 57 (71.0%) of C. amalonaticus and 47 (57%) from C. braakii. Oligonucleotide primers specific for the detection of tetA gene amplified the 417-bp PCR amplicons from 738 (18.0%) of tetracycline-resistant C. freundii only. The assay failed to amplify tetA genes from C. brakii or C. amalonaticus. Plasmids (2.0-16.0kb) were isolated from 14 of the 38 strains of C. freundii. Strains of C. amalonaticus and C. brakii did not contain any plasmids. Dendrogram analysis of the SpeI pulsed field gel electrophoresis (PFGE) results identified 23 distinct macrorestriction patterns (mrps) among the 36 strains of C. freundii, 3 distinct mrps among the 7 strains of C. braakii and 4 unique mrps among the 7 strains of C. amalonaticus. Our results indicate that citrobacters from catfish could serve as reservoirs of tetracycline-resistance determinants. JF - Food microbiology AU - Nawaz, Mohamed AU - Khan, Ashraf A AU - Khan, Saeed AU - Sung, Kidon AU - Steele, Roger AD - Division of Microbiology, National Center for Toxicological Research, Jefferson, AR 72079, USA. mohamed.nawaz@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 85 EP - 91 VL - 25 IS - 1 SN - 0740-0020, 0740-0020 KW - DNA Primers KW - 0 KW - Index Medicus KW - Animals KW - Consumer Product Safety KW - Drug Resistance, Multiple, Bacterial -- genetics KW - Humans KW - Polymerase Chain Reaction -- methods KW - Electrophoresis, Gel, Pulsed-Field KW - Plasmids KW - Species Specificity KW - Microbial Sensitivity Tests KW - Gene Amplification KW - Tetracycline Resistance -- genetics KW - Citrobacter -- drug effects KW - Catfishes -- microbiology KW - Citrobacter -- isolation & purification KW - Food Contamination -- analysis KW - Citrobacter -- classification KW - Seafood -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70098755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+microbiology&rft.atitle=Isolation+and+characterization+of+tetracycline-resistant+Citrobacter+spp.+from+catfish.&rft.au=Nawaz%2C+Mohamed%3BKhan%2C+Ashraf+A%3BKhan%2C+Saeed%3BSung%2C+Kidon%3BSteele%2C+Roger&rft.aulast=Nawaz&rft.aufirst=Mohamed&rft.date=2008-02-01&rft.volume=25&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Food+microbiology&rft.issn=07400020&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-11 N1 - Date created - 2007-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of scaffold end frame carrying strategies on worker stepping response, postural stability, and perceived task difficulty. AN - 68565071; 18354969 AB - OBJECTIVE This study determined the most favorable strategy for carrying scaffold end frames while minimizing the risk of injuries from being struck by an object, falling, and overexertion. BACKGROUND Scaffold erectors are at risk of high exposure to the aforementioned hazards associated with the dynamic human-scaffolding interface and work environments. Identifying an optimal work strategy can help reduce risk of injuries to the worker. METHOD Three carrying methods, four types of work surfaces, two weights of scaffold frames, and three directions of stepping movement were tested in a laboratory with 18 construction workers. RESULTS The effects of carrying method on postural instability and task difficulty rating were significant for handling the 22-kg end frame. Response time, postural instability, and perceived task difficulty rating were significantly reduced when the 9-kg end frame was used as compared with the 22-kg frame. CONCLUSION The symmetric side-carrying method was the best option for handling 22-kg scaffold end frames. A 9-kg end frame (e.g., made of reinforced lightweight materials) has the potential to reduce injury risk among scaffold handlers during their scaffold erection and dismantlingjobs. APPLICATION Scaffold erectors may want to adopt the symmetric side-carrying method as the primary technique for handling the 22-kg scaffold end frame, which is currently the one most used in the industry. JF - Human factors AU - Hsiao, Hongwei AU - Hause, Mathew AU - Powers, John R AU - Kau, Tsui-Ying AU - Hendricks, Scott AU - Simeonov, Peter I AD - Protective Technology Branch, NIOSH, 1095 Willowdale Rd., Morgantown, WV 26505, USA. hhsiao@cdc.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 27 EP - 36 VL - 50 IS - 1 SN - 0018-7208, 0018-7208 KW - Index Medicus KW - Space life sciences KW - United States KW - Occupational Health KW - Accidents, Occupational -- prevention & control KW - Altitude KW - Humans KW - Adult KW - Task Performance and Analysis KW - Middle Aged KW - Male KW - Postural Balance KW - Walking KW - Facility Design and Construction KW - Lifting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68565071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+factors&rft.atitle=Effect+of+scaffold+end+frame+carrying+strategies+on+worker+stepping+response%2C+postural+stability%2C+and+perceived+task+difficulty.&rft.au=Hsiao%2C+Hongwei%3BHause%2C+Mathew%3BPowers%2C+John+R%3BKau%2C+Tsui-Ying%3BHendricks%2C+Scott%3BSimeonov%2C+Peter+I&rft.aulast=Hsiao&rft.aufirst=Hongwei&rft.date=2008-02-01&rft.volume=50&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Human+factors&rft.issn=00187208&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-24 N1 - Date created - 2008-03-21 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Behavioral problems following reunification of children in long-term foster care AN - 61426850; 200907659 AB - Although reunification is the most common and preferred exit from the U.S. foster care system, little is known about the well-being of children following foster care. Even less is known about reunification following long-term foster care. Geographically limited studies suggest poor behavioral outcomes following reunification. A secondary data analysis was performed using a subsample of 604 children from the National Study of Child and Adolescent Well-being (NSCAW) who had experienced at least 8 months of foster care. Multiple imputation (MI) was employed to address missing data. Descriptive statistics, logistic regression, and propensity score matching are used to explore the role of risks and reunification in children's well-being from baseline to 36-month follow-up. Results indicate that reunification has no direct effect on behavioral outcomes, but is associated with increased risks in the family context of children who are reunified. Findings highlight the complex nature of the relationship between reunification and behavioral outcomes, as well as the need for reunification interventions that specifically target parental mental health and children's internalizing behaviors. Reunification research using longitudinal data and qualitative methods is recommended to clarify risks and outcomes across time. [Copyright 2007 Elsevier B.V.] JF - Children and Youth Services Review AU - Bellamy, Jennifer L AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, Campus Box 1093, One Brookings Drive, St. Louis, MO 63130-4899 jbellamy@wustl.edu Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 216 EP - 228 PB - Elsevier Ltd, Amsterdam The Netherlands VL - 30 IS - 2 SN - 0190-7409, 0190-7409 KW - Foster care Reunification Behavior problems Multiple imputation Propensity score matching KW - Family Relations KW - Child Welfare Services KW - Behavior Problems KW - Foster Care KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61426850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Children+and+Youth+Services+Review&rft.atitle=Behavioral+problems+following+reunification+of+children+in+long-term+foster+care&rft.au=Bellamy%2C+Jennifer+L&rft.aulast=Bellamy&rft.aufirst=Jennifer&rft.date=2008-02-01&rft.volume=30&rft.issue=2&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Children+and+Youth+Services+Review&rft.issn=01907409&rft_id=info:doi/10.1016%2Fj.childyouth.2007.09.008 LA - English DB - Social Services Abstracts N1 - Date revised - 2009-10-02 N1 - Number of references - 40 N1 - Last updated - 2016-09-28 N1 - CODEN - CYSRDU N1 - SubjectsTermNotLitGenreText - Foster Care; Family Relations; Behavior Problems; Child Welfare Services DO - http://dx.doi.org/10.1016/j.childyouth.2007.09.008 ER - TY - BOOK T1 - Expanding Our Understanding of the Psychosocial Work Environment AN - 58769887; 2008-150285 AB - There is broad recognition that the psychosocial environment at work can affect physical and mental health as well as organizational outcomes such as work performance and effectiveness. This has been the focus of publications, recommendations and conferences developed by the NORA Organization of Work Team ). Past research across several disciplines has revealed that gender- and race-related factors such as values, biases, harassment, discrimination, and lack of support for work-family balance can affect physical and mental health. However, these features of the work environment have rarely been included simultaneously with the study of other workplace conditions. Thus, knowledge is still very limited about correlations among them, as well as about potential confounding and interactions. This document is targeted to occupational safety and health researchers interested in evaluating the role of discrimination, bias and work-family issues in occupational injuries and illness. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Feb 2008, 260 pp. AU - Bond, Meg A AU - Cazeca, Dianne AU - Daniel, Sivan AU - Kalaja, Alketa AU - Markkanen, Pia AU - Punnet, Laura AU - Tsurikova, Lana Y1 - 2008/02// PY - 2008 DA - February 2008 EP - 260p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Work and labor KW - Social conditions and policy - Psychology KW - Business and service sector - Personnel management KW - Manufacturing and heavy industry - Industrial management, production, and productivity KW - Social conditions and policy - Public safety and security KW - Psychology KW - Safety measures KW - Work KW - Performance KW - Occupations KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58769887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Bond%2C+Meg+A%3BCazeca%2C+Dianne%3BDaniel%2C+Sivan%3BKalaja%2C+Alketa%3BMarkkanen%2C+Pia%3BPunnet%2C+Laura%3BTsurikova%2C+Lana&rft.aulast=Bond&rft.aufirst=Meg&rft.date=2008-02-01&rft.volume=&rft.issue=&rft.spage=260p&rft.isbn=&rft.btitle=Expanding+Our+Understanding+of+the+Psychosocial+Work+Environment&rft.title=Expanding+Our+Understanding+of+the+Psychosocial+Work+Environment&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2008-104/pdfs/2008-104.pdf LA - English DB - PAIS Index N1 - Date revised - 2008-06-04 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - SuppNotes - NIOSH Publication No. 2008-108 N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Miners' Views About Personal Dust Monitors AN - 58768083; 2008-150284 AB - Coal workers' pneumoconiosis is the leading cause of death due to occupational illness among U.S. coal miners. This disease is caused by miners' exposure to excessive levels of respirable coal mine dust. A personal dust monitor (PDM) has recently been developed to provide near real-time feedback to miners regarding the level of respirable coal dust in the air they breathe. The main objective of this report is to document coal miners' reactions to this device and how they make use of the information it provides. It summarizes a field study by the National Institute for Occupational Safety and Health that documented the opinions of 30 miners at 4 underground coal mines concerning the use of PDMs. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Feb 2008, 53 pp. AU - Hall, Erica E AU - Peters, Robert H AU - Vaught, Charles AU - Volkwein, Jon C Y1 - 2008/02// PY - 2008 DA - February 2008 EP - 53p PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Mining and mineral resources KW - Health conditions and policy - Diseases and disorders KW - Social conditions and policy - Public safety and security KW - United States KW - Miners KW - Safety measures KW - Lung diseases KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58768083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Hall%2C+Erica+E%3BPeters%2C+Robert+H%3BVaught%2C+Charles%3BVolkwein%2C+Jon+C&rft.aulast=Hall&rft.aufirst=Erica&rft.date=2008-02-01&rft.volume=&rft.issue=&rft.spage=53p&rft.isbn=&rft.btitle=Miners%27+Views+About+Personal+Dust+Monitors&rft.title=Miners%27+Views+About+Personal+Dust+Monitors&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2008-110.pdf LA - English DB - PAIS Index N1 - Date revised - 2008-06-04 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2008 N1 - SuppNotes - NIOSH Publication No. 2008-110 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Public Mental Health: The Role of Population-Based and Macrosystems Interventions in the Wake of Hurricane Katrina AN - 57287897; 200915973 AB - Policy makers and decision makers are struggling to recognize the needs of shattered communities in the wake of unimaginable devastation. Professional psychology is providing some of the answers as it examines the consequences of disaster. The authors, 6 U.S. Public Health Service commissioned officers, describe their experiences in this new arena. Working at the federal, state, and local levels of government during the national response to the Hurricane Katrina disaster, the authors strive to identify high-value practice areas and define new roles for professional psychologists. The authors suggest that traditional crisis and trauma interventions are expanding to include nontraditional population-based and macrosystems-level interventions. Such roles are explored in narrative form, providing professional and personal insight into the impact that psychologists can have on decision makers who recognize their value and position them effectively. [Copyright Elsevier B.V.] JF - Professional Psychology: Research and Practice AU - McGuinness, Kevin M AU - Coady, Jeff A AU - Perez, Jon T AU - Williams, N Chanell AU - McIntyre, David J AU - Schreiber, Merritt D AD - Health Resources and Services Administration kmcguinness@hrsa.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 58 EP - 65 PB - American Psychological Association, Washington DC VL - 39 IS - 1 SN - 0735-7028, 0735-7028 KW - population-based macrosystems Katrina USNS Mercy systemic KW - Crisis intervention KW - Hurricanes KW - Public health policy KW - Psychologists KW - Policy making KW - Work roles KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57287897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Professional+Psychology%3A+Research+and+Practice&rft.atitle=Public+Mental+Health%3A+The+Role+of+Population-Based+and+Macrosystems+Interventions+in+the+Wake+of+Hurricane+Katrina&rft.au=McGuinness%2C+Kevin+M%3BCoady%2C+Jeff+A%3BPerez%2C+Jon+T%3BWilliams%2C+N+Chanell%3BMcIntyre%2C+David+J%3BSchreiber%2C+Merritt+D&rft.aulast=McGuinness&rft.aufirst=Kevin&rft.date=2008-02-01&rft.volume=39&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Professional+Psychology%3A+Research+and+Practice&rft.issn=07357028&rft_id=info:doi/10.1037%2F0735-7028.39.1.58 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hurricanes; Crisis intervention; Psychologists; Work roles; Public health policy; Policy making DO - http://dx.doi.org/10.1037/0735-7028.39.1.58 ER - TY - JOUR T1 - Modeling and prediction of ventilation methane emissions of U.S. longwall mines using supervised artificial neural networks AN - 50131426; 2009-098710 AB - Methane emissions from a longwall ventilation system are an important indicator of how much methane a particular mine is producing and how much air should be provided to keep the methane levels under statutory limits. Knowing the amount of ventilation methane emission is also important for environmental considerations and for identifying opportunities to capture and utilize the methane for energy production. Prediction of methane emissions before mining is difficult since it depends on a number of geological, geographical, and operational factors. This study proposes a principle component analysis (PCA) and artificial neural network (ANN)-based approach to predict the ventilation methane emission rates of U.S. longwall mines. Ventilation emission data obtained from 63 longwall mines in 10 states for the years between 1985 and 2005 were combined with corresponding coalbed properties, geographical information, and longwall operation parameters. The compiled database resulted in 17 parameters that potentially impacted emissions. PCA was used to determine those variables that most influenced ventilation emissions and were considered for further predictive modeling using ANN. Different combinations of variables in the data set and network structures were used for network training and testing to achieve minimum mean square errors and high correlations between measurements and predictions. The resultant ANN model using nine main input variables was superior to multilinear and second-order non-linear models for predicting the new data. The ANN model predicted methane emissions with high accuracy. It is concluded that the model can be used as a predictive tool since it includes those factors that influence longwall ventilation emission rates. JF - International Journal of Coal Geology AU - Karacan, C Ozgen Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 371 EP - 387 PB - Elsevier, Amsterdam VL - 73 IS - 3-4 SN - 0166-5162, 0166-5162 KW - United States KW - mining KW - mines KW - numerical models KW - geologic hazards KW - underground mining KW - principal components analysis KW - natural gas KW - statistical analysis KW - coal mines KW - prediction KW - petroleum KW - coal seams KW - ventilation KW - safety KW - longwall mining KW - mathematical methods KW - coalbed methane KW - neural networks KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50131426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Modeling+and+prediction+of+ventilation+methane+emissions+of+U.S.+longwall+mines+using+supervised+artificial+neural+networks&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2008-02-01&rft.volume=73&rft.issue=3-4&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2007.09.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2009-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - coal mines; coal seams; coalbed methane; geologic hazards; longwall mining; mathematical methods; mines; mining; natural gas; neural networks; numerical models; petroleum; prediction; principal components analysis; safety; statistical analysis; underground mining; United States; ventilation DO - http://dx.doi.org/10.1016/j.coal.2007.09.003 ER - TY - JOUR T1 - Clinically relevant end points and new drug approvals for myeloma AN - 220572053; 17972944 AB - This manuscript summarizes the recommendations of the American Society of Hematology/US Food and Drug Administration Workshop on Clinical Endpoints in Multiple Myeloma, which brought together clinical investigators in multiple myeloma, the United States Food and Drug Administration, pharmaceutical companies, patient advocates and other concerned scientists and physicians to provide guidance, consensus and consistency in the definition of clinically relevant end points to expedite new drug approvals for multiple myeloma in the appropriate trial design settings. This manuscript will therefore be a most valuable resource to provide the framework for the design of appropriate clinical trial strategies for more rapid new drug approval in myeloma. JF - Leukemia AU - Rajkumar, S V AU - Stewart, A K AU - Weber, D AU - Richardson, P Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 231 EP - 9 CY - London PB - Nature Publishing Group VL - 22 IS - 2 SN - 08876924 KW - Medical Sciences--Oncology KW - United States KW - Humans KW - United States Food & Drug Administration KW - Treatment Outcome KW - Clinical Trials as Topic KW - Drug Approval -- methods KW - Endpoint Determination KW - Multiple Myeloma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220572053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=Clinically+relevant+end+points+and+new+drug+approvals+for+myeloma&rft.au=Rajkumar%2C+S+V%3BStewart%2C+A+K%3BWeber%2C+D%3BRichardson%2C+P&rft.aulast=Rajkumar&rft.aufirst=S&rft.date=2008-02-01&rft.volume=22&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Leukemia&rft.issn=08876924&rft_id=info:doi/10.1038%2Fsj.leu.2405016 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Feb 2008 N1 - Last updated - 2014-03-18 DO - http://dx.doi.org/10.1038/sj.leu.2405016 ER - TY - JOUR T1 - Prevalence and characterization of Salmonella enterica serovar Weltevreden from imported seafood AN - 21055330; 8253725 AB - During 2001-2005, 210 Salmonella enterica strains were isolated from seafood samples imported into US. Strains of S. enterica serovar Weltevreden were the most predominantly found among the 64 different serovars isolated. A total of 37 Salmonella Weltevreden isolates were characterized by pulsed-field gel electrophoresis (PFGE), plasmid profiles and antibiotic susceptibility to assess genetic diversity. Our results showed a low frequency of antibiotic resistance; 35 of the 37 isolates were sensitive to ampicillin, tetracycline, chloramphenicol, gentamicin, sulfisoxazole, streptomycin and kanamycin. Only two isolates, from samples originating in the Philippines and India, showed resistance to ampicillin and tetracycline and to streptomycin, sulfisoxazole and tetracycline, respectively. Of the 37 isolates, two isolates did not carry any plasmid and 35 isolates harbored several small and mega-plasmids. These isolates were differentiated into 10 distinct types based on plasmid profiles. Four different PFGE clusters were obtained with a genetic similarity of 66-76%. Four groups of isolates (formed by two or three isolates each) showed 100% similarity in the PFGE profiles. One of these groups included strains isolated in Vietnam in 2003, 2004 and 2005 from fish and shrimp. The other groups included strains isolated in Vietnam, Indonesia and Thailand in 2000, 2004 and 2005 from snail, shrimp and fish. Our findings show genetic diversity and temporal persistence of S. enterica serovar Weltevreden in recently monitored seafood imports. JF - Food Microbiology AU - Ponce, E AU - Khan, A A AU - Cheng, C-M AU - Summage-West, C AU - Cerniglia, CE AD - Departamento de Biotecnologia Marina, Km. 107 carretera Tijuana-Ensenada, Ensenada, B.C. 22860, Mexico, ashraf.khan@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 29 EP - 35 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 25 IS - 1 SN - 0740-0020, 0740-0020 KW - Crabs KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Philippines KW - International trade KW - Thailand KW - antibiotic resistance KW - Quality assurance KW - Indonesia KW - Disease control KW - Genetic diversity KW - Sulfisoxazole KW - Kanamycin KW - Antibiotics KW - Streptomycin KW - Tetracyclines KW - India KW - Vietnam KW - Public health KW - Seafood KW - Antibiotic resistance KW - Chloramphenicol KW - Electrophoresis KW - Decapoda KW - Ampicillin KW - genetic diversity KW - Food contamination KW - Plasmids KW - Salmonella weltevreden KW - imports KW - Gentamicin KW - Salmonella enterica KW - Pulsed-field gel electrophoresis KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 4000:Food and Drugs KW - Q1 08627:Food quality and standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21055330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Prevalence+and+characterization+of+Salmonella+enterica+serovar+Weltevreden+from+imported+seafood&rft.au=Ponce%2C+E%3BKhan%2C+A+A%3BCheng%2C+C-M%3BSummage-West%2C+C%3BCerniglia%2C+CE&rft.aulast=Ponce&rft.aufirst=E&rft.date=2008-02-01&rft.volume=25&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2007.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Quality assurance; Disease control; Antibiotics; Seafood; Plasmids; Public health; Chloramphenicol; Sulfisoxazole; Ampicillin; Genetic diversity; Kanamycin; Streptomycin; Tetracyclines; Gentamicin; Pulsed-field gel electrophoresis; Antibiotic resistance; Electrophoresis; International trade; antibiotic resistance; genetic diversity; Food contamination; imports; Decapoda; Salmonella enterica; Salmonella weltevreden; Philippines; Thailand; Indonesia; Vietnam; India DO - http://dx.doi.org/10.1016/j.fm.2007.09.001 ER - TY - JOUR T1 - Dose-Response Model for Listeria monocytogenes-Induced Stillbirths in Nonhuman Primates AN - 21019136; 8037507 AB - A dose-response model using rhesus monkeys as a surrogate for pregnant women indicates that oral exposure to 10 super(7) CFU of Listeria monocytogenes results in about 50% stillbirths. Ten of 33 pregnant rhesus monkeys exposed orally to a single dose of 10 super(2) to 10 super(10) CFU of L. monocytogenes had stillbirths. A log-logistic model predicts a dose affecting 50% of animals at 10 super(7) CFU, comparable to an estimated 10 super(6) CFU based on an outbreak among pregnant women but much less than the extrapolated estimate (10 super(13) CFU) from the FDA-U.S. Department of Agriculture-CDC risk assessment using an exponential curve based on mouse data. Exposure and etiology of the disease are the same in humans and primates but not in mice. This information will aid in risk assessment, assist policy makers, and provide a model for mechanistic studies of L. monocytogenes-induced stillbirths. JF - Infection and Immunity AU - Smith, Mary Alice AU - Takeuchi, Kazue AU - Anderson, Gary AU - Ware, Glenn O AU - McClure, Harold M AU - Raybourne, Richard B AU - Mytle, Nutan AU - Doyle, Michael P AD - Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia 30602. Center for Food Safety, College of Agricultural and Environmental Sciences, University of Georgia, Griffin, Georgia 30223. Experimental Statistics, College of Agricultural and Environmental Sciences, University of Georgia, Athens, Georgia 30602. Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322. U.S. Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 726 EP - 731 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 2 SN - 0019-9567, 0019-9567 KW - Rhesus macaque KW - Rhesus monkey KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Risk assessment KW - Listeria monocytogenes KW - Etiology KW - Data processing KW - Colony-forming cells KW - Animal models KW - Macaca mulatta KW - Primates KW - Pregnancy KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21019136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Dose-Response+Model+for+Listeria+monocytogenes-Induced+Stillbirths+in+Nonhuman+Primates&rft.au=Smith%2C+Mary+Alice%3BTakeuchi%2C+Kazue%3BAnderson%2C+Gary%3BWare%2C+Glenn+O%3BMcClure%2C+Harold+M%3BRaybourne%2C+Richard+B%3BMytle%2C+Nutan%3BDoyle%2C+Michael+P&rft.aulast=Smith&rft.aufirst=Mary&rft.date=2008-02-01&rft.volume=76&rft.issue=2&rft.spage=726&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Etiology; Data processing; Colony-forming cells; Animal models; Pregnancy; Listeria monocytogenes; Macaca mulatta; Primates ER - TY - JOUR T1 - Comparison of Seven Techniques for Typing International Epidemic Strains of Clostridium difficile: Restriction Endonuclease Analysis, Pulsed-Field Gel Electrophoresis, PCR-Ribotyping, Multilocus Sequence Typing, Multilocus Variable-Number Tandem-Repeat Analysis, Amplified Fragment Length Polymorphism, and Surface Layer Protein A Gene Sequence Typing AN - 20930698; 8039120 AB - Using 42 isolates contributed by laboratories in Canada, The Netherlands, the United Kingdom, and the United States, we compared the results of analyses done with seven Clostridium difficile typing techniques: multilocus variable-number tandem-repeat analysis (MLVA), amplified fragment length polymorphism (AFLP), surface layer protein A gene sequence typing (slpAST), PCR-ribotyping, restriction endonuclease analysis (REA), multilocus sequence typing (MLST), and pulsed-field gel electrophoresis (PFGE). We assessed the discriminating ability and typeability of each technique as well as the agreement among techniques in grouping isolates by allele profile A (AP-A) through AP-F, which are defined by toxinotype, the presence of the binary toxin gene, and deletion in the tcdC gene. We found that all isolates were typeable by all techniques and that discrimination index scores for the techniques tested ranged from 0.964 to 0.631 in the following order: MLVA, REA, PFGE, slpAST, PCR-ribotyping, MLST, and AFLP. All the techniques were able to distinguish the current epidemic strain of C. difficile (BI/027/NAP1) from other strains. All of the techniques showed multiple types for AP-A (toxinotype 0, binary toxin negative, and no tcdC gene deletion). REA, slpAST, MLST, and PCR-ribotyping all included AP-B (toxinotype III, binary toxin positive, and an 18-bp deletion in tcdC) in a single group that excluded other APs. PFGE, AFLP, and MLVA grouped two, one, and two different non-AP-B isolates, respectively, with their AP-B isolates. All techniques appear to be capable of detecting outbreak strains, but only REA and MLVA showed sufficient discrimination to distinguish strains from different outbreaks. JF - Journal of Clinical Microbiology AU - Killgore, George AU - Thompson, Angela AU - Johnson, Stuart AU - Brazier, Jon AU - Kuijper, Ed AU - Pepin, Jacques AU - Frost, Eric H AU - Savelkoul, Paul AU - Nicholson, Brad AU - van den Berg, Renate J AU - Kato, Haru AU - Sambol, Susan P AU - Zukowski, Walter AU - Woods, Christopher AU - Limbago, Brandi AU - Gerding, Dale N AU - McDonald, LClifford AD - Centers for Disease Control and Prevention, Atlanta, Georgia. Hines VA Hospital, Hines, Illinois. Anarobe Reference Laboratory, National Public Health Service for Wales, Microbiology Cardiff University Hospital of Wales, Cardiff, United Kingdom. Department of Medical Microbiology, Center for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada. Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina. Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo, Japan. Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 431 EP - 437 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 46 IS - 2 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Amplified fragment length polymorphism KW - Gene deletion KW - Typing KW - Epidemics KW - Nucleotide sequence KW - Pulsed-field gel electrophoresis KW - Clostridium difficile KW - Endonuclease KW - Toxins KW - multilocus sequence typing KW - G 07880:Human Genetics KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20930698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Comparison+of+Seven+Techniques+for+Typing+International+Epidemic+Strains+of+Clostridium+difficile%3A+Restriction+Endonuclease+Analysis%2C+Pulsed-Field+Gel+Electrophoresis%2C+PCR-Ribotyping%2C+Multilocus+Sequence+Typing%2C+Multilocus+Variable-Number+Tandem-Repeat+Analysis%2C+Amplified+Fragment+Length+Polymorphism%2C+and+Surface+Layer+Protein+A+Gene+Sequence+Typing&rft.au=Killgore%2C+George%3BThompson%2C+Angela%3BJohnson%2C+Stuart%3BBrazier%2C+Jon%3BKuijper%2C+Ed%3BPepin%2C+Jacques%3BFrost%2C+Eric+H%3BSavelkoul%2C+Paul%3BNicholson%2C+Brad%3Bvan+den+Berg%2C+Renate+J%3BKato%2C+Haru%3BSambol%2C+Susan+P%3BZukowski%2C+Walter%3BWoods%2C+Christopher%3BLimbago%2C+Brandi%3BGerding%2C+Dale+N%3BMcDonald%2C+LClifford&rft.aulast=Killgore&rft.aufirst=George&rft.date=2008-02-01&rft.volume=46&rft.issue=2&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene deletion; Amplified fragment length polymorphism; Epidemics; Typing; Nucleotide sequence; Pulsed-field gel electrophoresis; Endonuclease; Toxins; multilocus sequence typing; Clostridium difficile ER - TY - JOUR T1 - ACUT2E TSE-SSFP: A hybrid method for T2-weighted imaging of edema in the heart AN - 20859374; 8368686 AB - ACUT2E TSE-SSFP is a hybrid between steady state free precession (SSFP) and turbo spin echo (TSE) for bright-blood T2-weighted imaging with signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) similar to dark-blood TSE. TSE-SSFP uses a segmented SSFP readout during diastole with 180DG pulses following a 90DG preparation. The 180DG refocusing pulses make TSE-SSFP similar to TSE but TSE-SSFP uses gradient moment nulling, whereas TSE uses gradient crushing. TSE-SSFP produced T2-weighted images with minimal T1 weighting. TSE-SSFP and TSE had similar SNR (155.9 - 6.0 vs 160.9 - 7.0; P = NS) for acute myocardial infarction (MI) and twice the SNR of T2-prepared SSFP (73.1 - 3.4, P < 0.001). TSE-SSFP and TSE had approximately double the CNR of T2-prepared SSFP for differentiating acute MI from normal myocardium. Imperfect blood suppression, present in all animals on some TSE images, was a problem eliminated by TSE-SSFP and T2-prepared SSFP. Magn Reson Med 59:229-235, 2008. JF - Magnetic Resonance in Medicine AU - Aletras, Anthony H AU - Kellman, Peter AU - Derbyshire, J Andrew AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland, aletrasa@nhlbi.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 229 EP - 235 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Blood KW - Hybrids KW - Edema KW - N.M.R. KW - imaging KW - Myocardial infarction KW - Myocardium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=ACUT2E+TSE-SSFP%3A+A+hybrid+method+for+T2-weighted+imaging+of+edema+in+the+heart&rft.au=Aletras%2C+Anthony+H%3BKellman%2C+Peter%3BDerbyshire%2C+J+Andrew%3BArai%2C+Andrew+E&rft.aulast=Aletras&rft.aufirst=Anthony&rft.date=2008-02-01&rft.volume=59&rft.issue=2&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21490 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - imaging; Hybrids; N.M.R.; Blood; Myocardium; Myocardial infarction; Heart; Edema DO - http://dx.doi.org/10.1002/mrm.21490 ER - TY - JOUR T1 - Infectious Disease Hospitalizations Among Infants in the United States AN - 20844401; 8041819 AB - OBJECTIVE. This study describes the burden and epidemiologic features of infectious disease hospitalizations among infants in the United States. METHODS. Hospitalizations with an infectious disease listed as a primary diagnosis for infants (1 million hospital days for infants. Infectious disease hospitalization rates were highest among boys and nonwhite infants. The most commonly listed diagnoses among the infant infectious disease hospitalizations included lower respiratory tract infections (59.0%), kidney, urinary tract, and bladder infections (7.6%), upper respiratory tract infections (6.5%), and septicemia (6.5%). The median cost of an infectious disease hospitalization was $2235, with total annual hospital costs of approximately $690 million, among infants in the United States. CONCLUSIONS. Infectious disease hospitalizations among infants account for substantial health care expenditures and hospital time in the United States, with respiratory disease hospitalizations constituting more than one half of all hospitalizations. Younger infants, boys, and nonwhite infants were at increased risk for infectious disease hospitalization. Measures to reduce racial disparities and the occurrence of respiratory tract infections should substantially decrease the infectious disease burden among infants. JF - Pediatrics AU - Yorita, Krista L AU - Holman, Robert C AU - Sejvar, James J AU - Steiner, Claudia A AU - Schonberger, Lawrence B AD - Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Healthcare Cost and Utilization Project, Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 244 EP - 252 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - 2 SN - 0031-4005, 0031-4005 KW - Microbiology Abstracts B: Bacteriology KW - Respiratory tract diseases KW - Databases KW - Age KW - Infectious diseases KW - Septicemia KW - Urinary bladder KW - Kidney KW - Urinary tract KW - Infection KW - Infants KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20844401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Infectious+Disease+Hospitalizations+Among+Infants+in+the+United+States&rft.au=Yorita%2C+Krista+L%3BHolman%2C+Robert+C%3BSejvar%2C+James+J%3BSteiner%2C+Claudia+A%3BSchonberger%2C+Lawrence+B&rft.aulast=Yorita&rft.aufirst=Krista&rft.date=2008-02-01&rft.volume=121&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Databases; Respiratory tract diseases; Age; Septicemia; Infectious diseases; Urinary bladder; Kidney; Urinary tract; Infection; Hospitals; Infants ER - TY - JOUR T1 - Mathematical treatment of plates with colony counts outside the acceptable range AN - 20779855; 8253732 AB - The exclusion of plate counts outside of an acceptable range can bias the estimation of concentration. If these plates are too numerous to count (TNTC), then their microbes may be inhibited. If inhibition of the microbes on a plate is suspected, then its count may be best treated as a lower bound. When these lower bounds replace counts for some plates, the estimate and confidence interval must be calculated accordingly. Also, a measure of unusualness for plate counts is discussed. JF - Food Microbiology AU - Blodgett, R J AD - Food and Drug Administration, Room 2D-011, HFS-012, 5100 Paint Branch Parkway, College Park, MD 20740, USA, robert.blodgett@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 92 EP - 98 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 25 IS - 1 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Colonies KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20779855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Mathematical+treatment+of+plates+with+colony+counts+outside+the+acceptable+range&rft.au=Blodgett%2C+R+J&rft.aulast=Blodgett&rft.aufirst=R&rft.date=2008-02-01&rft.volume=25&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2007.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Colonies DO - http://dx.doi.org/10.1016/j.fm.2007.07.006 ER - TY - JOUR T1 - In Silico Screening of Chemicals for Genetic Toxicity Using MDL-QSAR, Nonparametric Discriminant Analysis, E-State, Connectivity, and Molecular Property Descriptors AN - 20732876; 8883061 AB - Genetic toxicity testing is a critical parameter in the safety assessment of pharmaceuticals, food constituents, and environmental and industrial chemicals. Quantitative structure-activity relationship (QSAR) software offers a rapid, cost-effective means of prioritizing the genotoxic potential of chemicals. Our goal is to develop and validate a complete battery of complementary QSAR models for genetic toxicity. We previously reported the development of MDL-QSAR models for the prediction of mutations in Salmonella typhimurium and Escherichia coli (Contrera et al. 2005b); this report describes the development of eight additional models for mutagenicity, clastogenicity, and DNA damage. The models were created using MDL-QSAR atom-type E-state, simple connectivity and molecular property descriptor categories, and nonparametric discriminant analysis. In 10% leave-group-out internal validation studies, the specificity of the models ranged from 63% for the mouse lymphoma (L5178Y-tk) model to 88% for chromosome aberrations in vivo. Sensitivity ranged from a high of 74% for the mouse lymphoma model to a low of 39% for the unscheduled DNA synthesis model. The receiver operator characteristic (ROC) was >=2.00, a value indicative of good predictive performance. The predictive performance of MDL-QSAR models was also shown to compare favorably to the results of MultiCase MC4PC (Matthews et al. 2006b) genotoxicity models prepared with the same training data sets. MDL-QSAR software models exhibit good specificity, sensitivity, and coverage and they can provide rapid and cost-effective large-scale screening of compounds for genotoxic potential by the chemical and pharmaceutical industry and for regulatory decision support applications. JF - Toxicology Mechanisms and Methods AU - Contrera, Joseph F AU - Matthews, Edwin J AU - Kruhlak, Naomi L AU - Benz, R Daniel AD - Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 207 EP - 216 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 18 IS - 2-3 SN - 1537-6516, 1537-6516 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - DNA biosynthesis KW - Molecular modelling KW - Mutagenicity KW - Data processing KW - Food KW - Genotoxicity KW - Salmonella typhimurium KW - Models KW - Operators KW - DNA damage KW - Computer programs KW - software KW - Clastogenicity KW - Escherichia coli KW - Pharmaceuticals KW - Toxicity testing KW - Chromosome aberrations KW - Lymphoma KW - Structure-activity relationships KW - Mutation KW - J 02410:Animal Diseases KW - N 14820:DNA Metabolism & Structure KW - G 07770:Bacteria KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20732876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=In+Silico+Screening+of+Chemicals+for+Genetic+Toxicity+Using+MDL-QSAR%2C+Nonparametric+Discriminant+Analysis%2C+E-State%2C+Connectivity%2C+and+Molecular+Property+Descriptors&rft.au=Contrera%2C+Joseph+F%3BMatthews%2C+Edwin+J%3BKruhlak%2C+Naomi+L%3BBenz%2C+R+Daniel&rft.aulast=Contrera&rft.aufirst=Joseph&rft.date=2008-02-01&rft.volume=18&rft.issue=2-3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376510701857106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; DNA biosynthesis; Mutagenicity; Data processing; Food; Genotoxicity; Models; Operators; Computer programs; DNA damage; software; Clastogenicity; Pharmaceuticals; Mutation; Structure-activity relationships; Lymphoma; Chromosome aberrations; Toxicity testing; Escherichia coli; Salmonella typhimurium DO - http://dx.doi.org/10.1080/15376510701857106 ER - TY - JOUR T1 - The public health approach to occupational injury research: From surveillance to prevention AN - 20653806; 8099868 AB - The National Institute for Occupational Safety and Health (NIOSH) in the US uses the public health model as the framework for occupational injury prevention research. This model is described, along with where we have made progress in this research process, and where we need to focus our efforts in the future. The specific role of surveillance in research and prevention of occupational injuries is also discussed, as well as the importance of partnership efforts to facilitate the transfer of research to practice. Suggestions are provided for stimulating a global approach to surveillance and to the transfer of research to practice. JF - Safety Science AU - Stout, NA AD - National Institute for Occupational Safety and Health, CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA, nas5@cdc.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 230 EP - 233 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 46 IS - 2 SN - 0925-7535, 0925-7535 KW - Health & Safety Science Abstracts KW - Injuries KW - Occupational safety KW - prevention KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20653806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+Science&rft.atitle=The+public+health+approach+to+occupational+injury+research%3A+From+surveillance+to+prevention&rft.au=Stout%2C+NA&rft.aulast=Stout&rft.aufirst=NA&rft.date=2008-02-01&rft.volume=46&rft.issue=2&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Safety+Science&rft.issn=09257535&rft_id=info:doi/10.1016%2Fj.ssci.2007.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational safety; prevention; Injuries DO - http://dx.doi.org/10.1016/j.ssci.2007.04.009 ER - TY - JOUR T1 - Isolation and Characterization of Vibrio tubiashii Outer Membrane Proteins and Determination of a toxR Homolog AN - 20622775; 8032753 AB - Outer membrane proteins (OMPs) expressed by Vibrio tubiashii under different environmental growth conditions were characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, N-terminal amino acid sequencing, and PCR analyses. Results showed the presence of a 38- to 40-kDa OmpU-like protein and ompU gene, a maltoporin-like protein, several novel OMPs, and a regulatory toxR homolog. JF - Applied and Environmental Microbiology AU - Beaubrun, JJean-Gilles AU - Kothary, M H AU - Curtis, S K AU - Flores, N C AU - Eribo, B E AU - Tall, B D AD - Howard University, Washington, D.C. 20050. U.S. Food and Drug Administration, Laurel, Maryland 20708 Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 907 EP - 911 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 74 IS - 3 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - outer membrane proteins KW - Amino acids KW - Growth conditions KW - Nucleotide sequence KW - Vibrio tubiashii KW - Gel electrophoresis KW - Biological membranes KW - OmpU protein KW - Microorganisms KW - DNA KW - Polymerase chain reaction KW - Proteins KW - Q1 08206:Physiology, biochemistry, biophysics KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20622775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Isolation+and+Characterization+of+Vibrio+tubiashii+Outer+Membrane+Proteins+and+Determination+of+a+toxR+Homolog&rft.au=Beaubrun%2C+JJean-Gilles%3BKothary%2C+M+H%3BCurtis%2C+S+K%3BFlores%2C+N+C%3BEribo%2C+B+E%3BTall%2C+B+D&rft.aulast=Beaubrun&rft.aufirst=JJean-Gilles&rft.date=2008-02-01&rft.volume=74&rft.issue=3&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Amino acids; Nucleotide sequence; DNA; Microorganisms; Proteins; Polymerase chain reaction; Biological membranes; outer membrane proteins; Growth conditions; OmpU protein; Gel electrophoresis; Vibrio tubiashii ER - TY - JOUR T1 - Review: Cleaning and Other Control and Validation Strategies To Prevent Allergen Cross-Contact in Food-Processing Operations AN - 20600753; 8129950 AB - Food allergies affect an estimated 10 to 12 million people in the United States. Some of these individuals can develop life-threatening allergic reactions when exposed to allergenic proteins. At present, the only successful method to manage food allergies is to avoid foods containing allergens. Consumers with food allergies rely on food labels to disclose the presence of allergenic ingredients. However, undeclared allergens can be inadvertently introduced into a food via cross-contact during manufacturing. Although allergen removal through cleaning of shared equipment or processing lines has been identified as one of the critical points for effective allergen control, there is little published information on the effectiveness of cleaning procedures for removing allergenic materials from processing equipment. There also is no consensus on how to validate or verify the efficacy of cleaning procedures. The objectives of this review were (i) to study the incidence and cause of allergen cross-contact, (ii) to assess the science upon which the cleaning of food contact surfaces is based, (iii) to identify best practices for cleaning allergenic foods from food contact surfaces in wet and dry manufacturing environments, and (iv) to present best practices for validating and verifying the efficacy of allergen cleaning protocols. JF - Journal of Food Protection AU - Jackson, Lauren S AU - Al-Taher, Fadwa M AU - Moorman, Mark AU - Devries, Jonathan W AU - Tippett, Roger AU - Swanson, Katherine MJ AU - Fu, Tong-Jen AU - Salter, Robert AU - Dunaif, George AU - Estes, Susan AU - Albillos, Silvia AU - Gendel, Steven M AD - U.S. Food and Drug Administration Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 445 EP - 458 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 71 IS - 2 SN - 0362-028X, 0362-028X KW - Health & Safety Science Abstracts KW - USA KW - best practices KW - Allergens KW - Reviews KW - Proteins KW - Food contamination KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20600753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Review%3A+Cleaning+and+Other+Control+and+Validation+Strategies+To+Prevent+Allergen+Cross-Contact+in+Food-Processing+Operations&rft.au=Jackson%2C+Lauren+S%3BAl-Taher%2C+Fadwa+M%3BMoorman%2C+Mark%3BDevries%2C+Jonathan+W%3BTippett%2C+Roger%3BSwanson%2C+Katherine+MJ%3BFu%2C+Tong-Jen%3BSalter%2C+Robert%3BDunaif%2C+George%3BEstes%2C+Susan%3BAlbillos%2C+Silvia%3BGendel%2C+Steven+M&rft.aulast=Jackson&rft.aufirst=Lauren&rft.date=2008-02-01&rft.volume=71&rft.issue=2&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/10.1043%2F0362-028X%282008%29071%253C0445%3ARCAOCA%253E2.3.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - best practices; Reviews; Allergens; Proteins; Food contamination; USA DO - http://dx.doi.org/10.1043/0362-028X(2008)071%3C0445:RCAOCA%3E2.3.CO;2 ER - TY - JOUR T1 - Low-Level Neonatal Thimerosal Exposure: Further Evaluation of Altered Neurotoxic Potential in SJL Mice AN - 20566983; 8043208 AB - Ethylmercury in thimerosal-preserved childhood vaccines has been suggested to be neurotoxic and to contribute to the etiology of neurodevelopmental disorders, including autism. Immune system function may be an important factor influencing vulnerability of the developing nervous system to thimerosal. This possibility is based in part on a report by Hornig et al. (2004, Mol. Psychiatry 9, 833-845) of neurodevelomental toxicity in SJL/J mice that develop autoantibodies when exposed to organic mercury. The present study reexamined this possibility by injecting neonatal SJL/J mice with thimerosal, with and without combined HiB and DTP vaccines. Injections modeled childhood vaccination schedules, with mice injected on postnatal days 7, 9, 11, and 15 with 14.2, 10.8, 9.2, and 5.6 mu g/kg mercury from thimerosal, respectively, or vehicle. Additional groups received vaccine only or a 10 times higher thimerosal + vaccine dose. Low levels of mercury were found in blood, brain, and kidneys 24 h following the last thimerosal injection. Survival, body weight, indices of early development (negative geotaxis, righting) and hippocampal morphology were not affected. Performance was unaffected in behavioral tests selected to assess behavioral domains relevant to core deficits in neurodevelopmental disorders such as autism (i.e., social interaction, sensory gating, anxiety). In an open-field test the majority of behaviors were unaffected by thimerosal injection, although thimerosal-injected female mice showed increased time in the margin of an open field at 4 weeks of age. Considered together the present results do not indicate pervasive developmental neurotoxicity following vaccine-level thimerosal injections in SJL mice, and provide little if any support for the hypothesis that thimerosal exposure contributes to the etiology of neurodevelopmental disorders. JF - Toxicological Sciences AU - Berman, Robert F AU - Pessah, Isaac N AU - Mouton, Peter R AU - Mav, Deepak AU - Harry, Jean AD - Department of Neurological Surgery and the Center for Children's Environmental Health. Center for Children's Environmental Health and Department of Molecular Biosciences, University of California Davis, California 95616. Laboratory of Experimental Gerontology NIA/NIH, Baltimore, Maryland 21224. Constella Group, LLC, Durham, North Carolina 27713. Neurotoxicology Group, Laboratory of Neurobiology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 294 EP - 309 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 101 IS - 2 SN - 1096-6080, 1096-6080 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - thimerosal KW - Neurodevelopmental disorders KW - Pertussis KW - Age KW - Anxiety KW - Hippocampus KW - Immune system KW - Survival KW - Tetanus KW - Nervous system KW - Body weight KW - Combined vaccines KW - Geotaxis KW - Etiology KW - Diphtheria KW - Children KW - Social interactions KW - Blood KW - Autoantibodies KW - Gating KW - Neurotoxicity KW - Kidney KW - Mercury KW - Vaccines KW - Neonates KW - Autism KW - Psychiatry KW - N3 11028:Neuropharmacology & toxicology KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20566983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Low-Level+Neonatal+Thimerosal+Exposure%3A+Further+Evaluation+of+Altered+Neurotoxic+Potential+in+SJL+Mice&rft.au=Berman%2C+Robert+F%3BPessah%2C+Isaac+N%3BMouton%2C+Peter+R%3BMav%2C+Deepak%3BHarry%2C+Jean&rft.aulast=Berman&rft.aufirst=Robert&rft.date=2008-02-01&rft.volume=101&rft.issue=2&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neurodevelopmental disorders; thimerosal; Pertussis; Age; Anxiety; Hippocampus; Immune system; Survival; Tetanus; Nervous system; Body weight; Combined vaccines; Geotaxis; Etiology; Diphtheria; Children; Social interactions; Blood; Autoantibodies; Gating; Neurotoxicity; Kidney; Mercury; Neonates; Vaccines; Psychiatry; Autism ER - TY - JOUR T1 - Risk Factors for Pediatric Invasive Pneumococcal Disease in the Intermountain West, 1996-2002 AN - 20561257; 9272816 AB - Purpose In response to concerns that the epidemiology of pediatric invasive pneumococcal disease (IPD) in the Intermountain West (i.e., Utah, Idaho, Wyoming, Montana, and parts of Arizona and Nevada) was poorly understood and might differ from elsewhere in the United States, a case-control study was undertaken to determine factors associated with IPD during 1996-2002. Methods A telephone questionnaire was administered to parents of children comprising 120 cases identified through hospital records and to parents of 156 age-matched controls located by random-digit dialing. The unit of analysis was each matched case-control set. Results Underlying chronic illness was reported for 32 (27%) of the cases. For previously healthy children, breastfeeding had a protective benefit (adjusted odds ratio: 0.2; 95% confidence interval [CI], 0.1-0.6), while a history of tympanostomy tube surgery was a risk factor (adjusted odds ratio: 12.6; 95% CI, 1.5-107.3). Conclusions The presence of an underlying chronic illness was the strongest risk factor for IPD. Except for a history of tympanostomy tube surgery, the factors associated with IPD in this investigation were similar to those reported from other geographic regions. Tympanostomy surgery might serve as a surrogate indicator for predisposition to recurrent otitis media or decreased ability to clear pneumococcal infection, raising risk for invasive disease. Pediatric clinicians should continue to encourage breastfeeding, and continued emphasis on pneumococcal vaccination should help prevent IPD. Key Words: Children; Streptococcus pneumoniae; Immunization; Utah Abbreviations: CI, confidence interval; Hib, Haemophilus influenzae type b; IPD, invasive pneumococcal disease; OR, odds ratio; PCV-7, 7-valent pneumococcal conjugate vaccine JF - Annals of Epidemiology AU - Haddad, Maryam B AU - Fnp AU - Porucznik, Christina A AU - Msph AU - Joyce, Kerry E AU - De, Anindya K AU - Pavia, Andrew T AU - Rolfs, Robert T AU - Byington, Carrie L AD - Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, maryam.haddad@cdc.hhs.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 139 EP - 146 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 18 IS - 2 SN - 1047-2797, 1047-2797 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - breast feeding KW - Historical account KW - vaccines KW - USA, Nevada KW - surgery KW - immunization KW - Surgery KW - Risk factors KW - infection KW - Breast feeding KW - Recurrent infection KW - USA, Montana KW - USA, Utah KW - Inventories KW - USA, Wyoming KW - Haemophilus influenzae KW - Pediatrics KW - USA, Utah, Intermountain West KW - Children KW - Vaccination KW - USA, Idaho KW - Streptococcus pneumoniae KW - Epidemiology KW - Otitis media KW - USA, Arizona KW - Vaccines KW - Hospitals KW - R2 23060:Medical and environmental health KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20561257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Risk+Factors+for+Pediatric+Invasive+Pneumococcal+Disease+in+the+Intermountain+West%2C+1996-2002&rft.au=Haddad%2C+Maryam+B%3BFnp%3BPorucznik%2C+Christina+A%3BMsph%3BJoyce%2C+Kerry+E%3BDe%2C+Anindya+K%3BPavia%2C+Andrew+T%3BRolfs%2C+Robert+T%3BByington%2C+Carrie+L&rft.aulast=Haddad&rft.aufirst=Maryam&rft.date=2008-02-01&rft.volume=18&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2007.09.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inventories; Epidemiology; Pediatrics; Otitis media; Risk factors; Surgery; Recurrent infection; Breast feeding; Vaccines; Children; Vaccination; Hospitals; immunization; breast feeding; Historical account; vaccines; infection; surgery; Streptococcus pneumoniae; Haemophilus influenzae; USA, Utah; USA, Idaho; USA, Wyoming; USA, Arizona; USA, Utah, Intermountain West; USA, Nevada; USA, Montana DO - http://dx.doi.org/10.1016/j.annepidem.2007.09.006 ER - TY - JOUR T1 - Development of hand-arm system models for vibrating tool analysis and test rig construction AN - 20522126; 8055044 AB - The vibration and noise generated by powered hand tools may be affected by human interaction with these tools. This effect can be taken into account by including a hand-arm system model in tool analysis and testing. The objective of this study is to propose a general methodology for developing practical models for tool analyses and test rig constructions. To demonstrate the methodology, this study applied three traditional models (2-, 3-, and 4-degree-of-freedom (DOF) models) as well as a new 4-DOF model proposed by the authors. The biodynamic responses to hand-transmitted vibration measured at the hand driving-point along the forearm direction under combined grip and push actions were used to determine the parameters of the models using a least root-mean-square error curve fitting method. This study found that the new 4-DOF model and the traditional 3-DOF and 4-DOF models accurately represented the experimental mechanical impedance (MI). The transmissibility functions predicted using these models were also consistent with their corresponding experimental data measured on the fingers and at the wrist. When judged using apparent mass (AM) instead of MI, the traditional 2-DOF model also fits the experimental data well. The parameters of the 2-DOF and new 4-DOF models are more reasonable than those of the other two models for test rig construction. This study concluded that the new 4-DOF model provides the best choice for analyzing tools and for constructing test rigs. However, if the hand-tool dynamic interactions below 100 Hz are of major concern, the 2-DOF model is simpler and less expensive for test rig construction. Whereas these two models can be directly used in some applications, the proposed methodology can be used to develop a more tool-specific model when biodynamic response data for the specific tool are available. JF - Noise Control Engineering Journal AU - Dong, R G AU - Welcome, DE AU - Wu, J Z AU - McDowell, T W AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS L-2027, Morgantown WV 26505 USA, rkd6@cdc.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 35 EP - 44 VL - 56 IS - 1 SN - 0736-2501, 0736-2501 KW - Health & Safety Science Abstracts KW - Man-machine interactions KW - Working conditions KW - Vibration KW - hand tools KW - Occupational exposure KW - Ergonomics KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20522126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+Control+Engineering+Journal&rft.atitle=Development+of+hand-arm+system+models+for+vibrating+tool+analysis+and+test+rig+construction&rft.au=Dong%2C+R+G%3BWelcome%2C+DE%3BWu%2C+J+Z%3BMcDowell%2C+T+W&rft.aulast=Dong&rft.aufirst=R&rft.date=2008-02-01&rft.volume=56&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Noise+Control+Engineering+Journal&rft.issn=07362501&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vibration; Ergonomics; Man-machine interactions; Occupational exposure; Working conditions; hand tools ER - TY - JOUR T1 - In Silico Toxicological Screening of Natural Products AN - 20279949; 8883063 AB - This study closely examines six well-known naturally occurring dietary chemicals (estragole, pulegone, aristolochic acid I, lipoic acid, 1-octacosanol, and epicatechin) with known human exposure, chemical metabolism, and mechanism of action (MOA) using in silico screening methods. The goal of this study was to take into consideration the available information on these chemicals in terms of MOA and experimentally determined toxicological data, and compare them to the in silico predictive modeling results produced from a series of computational toxicology software. After these analyses, a consensus modeling prediction was formulated in light of the weight of evidence for each natural product. We believe this approach of examining the experimentally determined mechanistic data for a given chemical and comparing it to in silico generated predictions and data mining is a valid means to evaluating the utility of the computational software, either alone or in combination with each other. We find that consensus predictions appear to be more accurate than the use of only one or two software programs and our in silico results are in very good agreement with the experimental toxicity data for the natural products screened in this study. JF - Toxicology Mechanisms and Methods AU - Arvidson, Kirk B AU - Valerio Jr, Luis G AU - Diaz, Marilyn AU - Chanderbhan, Ronald F AD - Division of Food Contact Notifications, U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 229 EP - 242 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 18 IS - 2-3 SN - 1537-6516, 1537-6516 KW - Toxicology Abstracts KW - Computer programs KW - software KW - Data processing KW - Aristolochic acid KW - pulegone KW - natural products KW - Toxicity KW - Computer applications KW - epicatechin KW - Metabolism KW - Lipoic acid KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20279949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=In+Silico+Toxicological+Screening+of+Natural+Products&rft.au=Arvidson%2C+Kirk+B%3BValerio+Jr%2C+Luis+G%3BDiaz%2C+Marilyn%3BChanderbhan%2C+Ronald+F&rft.aulast=Arvidson&rft.aufirst=Kirk&rft.date=2008-02-01&rft.volume=18&rft.issue=2-3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376510701856991 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Data processing; pulegone; Aristolochic acid; natural products; Toxicity; Computer applications; epicatechin; Lipoic acid; Metabolism DO - http://dx.doi.org/10.1080/15376510701856991 ER - TY - JOUR T1 - Development of a Phospholipidosis Database and Predictive Quantitative Structure-Activity Relationship (QSAR) Models AN - 20274987; 8883062 AB - Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development of pharmaceuticals. This report describes the construction of a database of PL findings in a variety of animal species and its use as a training data set for computational toxicology software. PL data and chemical structures were compiled from the published literature, existing pharmaceutical databases, and Food and Drug Administration (FDA) internal reports yielding a total of 583 compounds suitable for modeling. The database contained 190 (33%) positive drugs and 393 (77%) negative drugs, of which 39 were electron microscopy-confirmed negative compounds and 354 were classified as negatives due to the absence of positive reported data. Of the 190 positive findings, 76 were electron microscopy confirmed and 114 were considered positive based on other evidence. Quantitative structure-activity relationship (QSAR) models were constructed using two commercially available software programs, MC4PC and MDL-QSAR, and internal cross-validation (10 t 10%) experiments were performed to assess their predictive performance. Performance parameters for the MC4PC model were specificity 92%, sensitivity 50%, concordance 78%, positive predictivity 76%, and negative predictivity 78%. For MDL-QSAR, predictive performance was similar: specificity 80%, sensitivity 76%, concordance 79%, positive predictivity 65%, and negative predictivity 87%. By combining the output of the two QSAR programs, the overall predictive performance was vastly improved and sensitivity could be optimized to 81% without significant loss of specificity (79%). Many of the structural alerts and significant molecular descriptors obtained from the QSAR software were found to be associated with parts of active molecules known for their cationic amphiphilic drug (CAD) properties supporting the hypothesis that the endpoint of PL is statistically correlated with chemical structure. QSAR models can be useful tools for screening drug candidate molecules for potential PL. JF - Toxicology Mechanisms and Methods AU - Kruhlak, Naomi L AU - Choi, Sydney S AU - Contrera, Joseph F AU - Weaver, James L AU - Willard, James M AU - Hastings, Kenneth L AU - Sancilio, Lawrence F AD - U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Silver Spring, MD Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 217 EP - 227 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 18 IS - 2-3 SN - 1537-6516, 1537-6516 KW - Toxicology Abstracts KW - Molecular modelling KW - Data processing KW - Drug development KW - Computer applications KW - Models KW - Computer programs KW - Databases KW - software KW - Pharmaceuticals KW - Structure-activity relationships KW - Electron microscopy KW - Lysosomes KW - Phospholipids KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20274987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Development+of+a+Phospholipidosis+Database+and+Predictive+Quantitative+Structure-Activity+Relationship+%28QSAR%29+Models&rft.au=Kruhlak%2C+Naomi+L%3BChoi%2C+Sydney+S%3BContrera%2C+Joseph+F%3BWeaver%2C+James+L%3BWillard%2C+James+M%3BHastings%2C+Kenneth+L%3BSancilio%2C+Lawrence+F&rft.aulast=Kruhlak&rft.aufirst=Naomi&rft.date=2008-02-01&rft.volume=18&rft.issue=2-3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376510701857262 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Data processing; Drug development; Computer applications; Models; Databases; Computer programs; software; Pharmaceuticals; Structure-activity relationships; Lysosomes; Electron microscopy; Phospholipids DO - http://dx.doi.org/10.1080/15376510701857262 ER - TY - JOUR T1 - Reproducible and reliable microarray results through quality control: good laboratory proficiency and appropriate data analysis practices are essential AN - 20269696; 8853253 AB - Over a few short years, microarray gene expression profiling has permeated most areas of biomedical research. Microarrays are now poised to enter the more demanding realm of clinical applications. The prospect of using microarray data to derive biomarkers of disease or toxicity, predict prognosis, or select treatments raises the validity and reliability bar substantially higher. The potential future payoffs are huge in terms of faster approval of more efficacious and safer medical interventions, and a more personalized implementation of them. Arriving at the future sooner rather than later is the motivation for the FDA-led MicroArray Quality Control (MAQC) project. The widespread collaboration aims to assess achievable technical performance of microarrays and capabilities and limitations of methods for microarray data analysis. JF - Current Opinion in Biotechnology AU - Shi, Leming AU - Perkins, Roger G AU - Fang, Hong Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 10 EP - 18 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 19 IS - 1 SN - 0958-1669, 0958-1669 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - Motivation KW - Quality control KW - Reviews KW - Prognosis KW - Therapeutic applications KW - Toxicity KW - DNA microarrays KW - biomarkers KW - W 30910:Imaging KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20269696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Reproducible+and+reliable+microarray+results+through+quality+control%3A+good+laboratory+proficiency+and+appropriate+data+analysis+practices+are+essential&rft.au=Shi%2C+Leming%3BPerkins%2C+Roger+G%3BFang%2C+Hong&rft.aulast=Shi&rft.aufirst=Leming&rft.date=2008-02-01&rft.volume=19&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2007.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Motivation; Reviews; Quality control; Prognosis; Therapeutic applications; Toxicity; biomarkers; DNA microarrays DO - http://dx.doi.org/10.1016/j.copbio.2007.11.003 ER - TY - JOUR T1 - Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents AN - 20249914; 8883060 AB - This report describes a coordinated use of four quantitative structure-activity relationship (QSAR) programs and an expert knowledge base system to predict the occurrence and the mode of action of chemical carcinogenesis in rodents. QSAR models were based upon a weight-of-evidence paradigm of carcinogenic activity that was linked to chemical structures (n = 1,572). Identical training data sets were configured for four QSAR programs (MC4PC, MDL-QSAR, BioEpisteme, and Leadscope PDM), and QSAR models were constructed for the male rat, female rat, composite rat, male mouse, female mouse, composite mouse, and rodent composite endpoints. Model predictions were adjusted to favor high specificity (>80%). Performance was shown to be affected by the method used to score carcinogenicity study findings and the ratio of the number of active to inactive chemicals in the QSAR training data set. Results demonstrated that the four QSAR programs were complementary, each detecting different profiles of carcinogens. Accepting any positive prediction from two programs showed better overall performance than either of the single programs alone; specificity, sensitivity, and Chi-square values were 72.9%, 65.9%, and 223, respectively, compared to 84.5%, 45.8%, and 151. Accepting only consensus-positive predictions using any two programs had the best overall performance and higher confidence; specificity, sensitivity, and Chi-square values were 85.3%, 57.5%, and 287, respectively. Specific examples are provided to demonstrate that consensus-positive predictions of carcinogenicity by two QSAR programs identified both genotoxic and nongenotoxic carcinogens and that they detected 98.7% of the carcinogens linked in this study to Derek for Windows defined modes of action. JF - Toxicology Mechanisms and Methods AU - Matthews, Edwin J AU - Kruhlak, Naomi L AU - Benz, R Daniel AU - Contrera, Joseph F AU - Marchant, Carol A AU - Yang, Chihae AD - Informatics and Computational Safety Analysis Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 189 EP - 206 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 18 IS - 2-3 SN - 1537-6516, 1537-6516 KW - Toxicology Abstracts KW - Computer programs KW - software KW - Data processing KW - Carcinogenesis KW - Genotoxicity KW - Carcinogens KW - Structure-activity relationships KW - Lead KW - Models KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20249914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Combined+Use+of+MC4PC%2C+MDL-QSAR%2C+BioEpisteme%2C+Leadscope+PDM%2C+and+Derek+for+Windows+Software+to+Achieve+High-Performance%2C+High-Confidence%2C+Mode+of+Action-Based+Predictions+of+Chemical+Carcinogenesis+in+Rodents&rft.au=Matthews%2C+Edwin+J%3BKruhlak%2C+Naomi+L%3BBenz%2C+R+Daniel%3BContrera%2C+Joseph+F%3BMarchant%2C+Carol+A%3BYang%2C+Chihae&rft.aulast=Matthews&rft.aufirst=Edwin&rft.date=2008-02-01&rft.volume=18&rft.issue=2-3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.1080%2F15376510701857379 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Data processing; Genotoxicity; Carcinogenesis; Carcinogens; Structure-activity relationships; Lead; Models DO - http://dx.doi.org/10.1080/15376510701857379 ER - TY - JOUR T1 - Prevalence of allergic sensitization to indoor fungi in West Virginia AN - 20214251; 10147346 AB - Exposure to indoor fungi is of growing concern in residential and occupational environments in the United States. The purpose of this study was to determine the prevalence of sensitization to common indoor fungal species in an atopic population. We evaluated 102 patients (73 female and 29 male patients) for immunoglobulin E (IgE) reactivity to a panel of skin-prick test (SPT) reagents used for routine allergy testing. Patients also were tested for six additional fungi that are common indoor contaminants. All patients had symptoms consistent with allergic rhinitis or asthma. The presence of specific IgE against the fungal species was determined using immunoblotting. Of the 102 eligible patients, 68% had at least one positive skin test. The most prevalent positive SPTs were to dust mites, cats, vernal grass, and short ragweed. Overall, 21/102 (21%) patients with asthma or allergic rhinitis were skin test positive to at least one fungal extract. Of the patients with a positive SPT to fungi, 12/21 (58%) showed sensitivity to one or more of the newly tested species; most notably Trichoderma viride (8%), Chaetomium globosum (7%), Paecilomyces variotii (7%), and Acremonium strictum (6%). Immunoblotting revealed specific IgE against a number of protein bands belonging to these fungal species. The prevalence of fungal sensitization was common, particularly for indoor fungal contaminants that are not routinely included in SPT panels. Cross-reactivity with other fungi may partially explain our results; however, skin testing for these indoor fungi may provide useful diagnostic information. JF - Allergy and Asthma Proceedings AU - Beezhold, Donald H AU - Green, Brett J AU - Blachere, Francoise M AU - Schmechel, Detlef AU - Weissman, David N AU - Velickoff, Deborah AU - Hogan, Mary Beth AU - Wilson, Nevin W AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 29 EP - 34 PB - OceanSide Publications, Inc. VL - 29 IS - 1 SN - 1088-5412, 1088-5412 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - K 03410:Animal Diseases KW - F 06925:Hypersensitivity KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20214251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Allergy+and+Asthma+Proceedings&rft.atitle=Prevalence+of+allergic+sensitization+to+indoor+fungi+in+West+Virginia&rft.au=Beezhold%2C+Donald+H%3BGreen%2C+Brett+J%3BBlachere%2C+Francoise+M%3BSchmechel%2C+Detlef%3BWeissman%2C+David+N%3BVelickoff%2C+Deborah%3BHogan%2C+Mary+Beth%3BWilson%2C+Nevin+W&rft.aulast=Beezhold&rft.aufirst=Donald&rft.date=2008-02-01&rft.volume=29&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Allergy+and+Asthma+Proceedings&rft.issn=10885412&rft_id=info:doi/10.2500%2Faap2008.29.3076 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.2500/aap2008.29.3076 ER - TY - JOUR T1 - Prevalence and characterization of macrolide-lincomycin-streptogramin B-resistant Staphylococcus aureus in Korean hospitals AN - 20088096; 8037662 JF - Journal of Antimicrobial Chemotherapy AU - Jung, Young-Hee AU - Kim, Kwang Wook AU - Lee, Kyeong Min AU - Yoo, Jae Il AU - Chung, Gyung Tae AU - Kim, Bong Soo AU - Kwak, Hyo-Sun AU - Lee, Yeong Seon AD - Division of Antimicrobial Resistance, Center for Infectious Disease Research, National Institute of Health, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-701, Republic of Korea. Division of Biodefence Research, Center for Infectious Disease Research, National Institute of Health, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-701, Republic of Korea. Food Microbiology Team, Center for Food Safety Evaluation, Korea Food and Drug Administration, 194, Tongil-Lo, Eunpyung-Gu, Seoul 122-704, Republic of Korea Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 458 EP - 460 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 61 IS - 2 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology KW - Staphylococcus aureus KW - Hospitals KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20088096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Prevalence+and+characterization+of+macrolide-lincomycin-streptogramin+B-resistant+Staphylococcus+aureus+in+Korean+hospitals&rft.au=Jung%2C+Young-Hee%3BKim%2C+Kwang+Wook%3BLee%2C+Kyeong+Min%3BYoo%2C+Jae+Il%3BChung%2C+Gyung+Tae%3BKim%2C+Bong+Soo%3BKwak%2C+Hyo-Sun%3BLee%2C+Yeong+Seon&rft.aulast=Jung&rft.aufirst=Young-Hee&rft.date=2008-02-01&rft.volume=61&rft.issue=2&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hospitals; Staphylococcus aureus ER - TY - JOUR T1 - Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells AN - 19999113; 8095807 AB - In addition to occupational exposures to acrylamide (AA), concerns about AA health risks for the general population have been recently raised due to the finding of AA in food. In this study, we evaluated the genotoxicity of AA and its metabolite glycidamide (GA) in L5178Y/Tk super(+) super(/) super(-) mouse lymphoma cells. The cells were treated with 2-18mM of AA or 0.125-4mM of GA for 4h without metabolic activation. The DNA adducts, mutant frequencies and the types of mutations for the treated cells were examined. Within the dose range tested, GA induced DNA adducts of adenine and guanine [N3-(2-carbamoyl-2-hydroxyethyl)-adenine and N7-(2-carbamoyl-2-hydroxyethyl)-guanine] in a linear dose-dependent manner. The levels of guanine adducts were consistently about 60-fold higher across the dose range than those of adenine. In contrast, no GA-derived DNA adducts were found in the cells treated with any concentrations of AA, consistent with a lack of metabolic conversion of AA to GA. However, the mutant frequency was significantly increased by AA at concentrations of 12mM and higher. GA was mutagenic starting with the 2mM dose, suggesting that GA is much more mutagenic than AA. The mutant frequencies were increased with increasing concentrations of AA and GA, mainly due to an increase of proportion of small colony mutants. To elucidate the underlying mutagenic mechanism, we examined the loss of heterozygosity (LOH) at four microsatellite loci spanning the entire chromosome 11 for mutants induced by AA or GA. Compared to GA induced mutations, AA induced more mutants whose LOH extended to D11Mit22 and D11Mit74, an alteration of DNA larger than half of the chromosome. Statistical analysis of the mutational spectra revealed a significant difference between the types of mutations induced by AA and GA treatments (P=0.018). These results suggest that although both AA and GA generate mutations through a clastogenic mode of action in mouse lymphoma cells, GA induces mutations via a DNA adduct mechanism whereas AA induces mutations by a mechanism not involving the formation of GA adducts. JF - Food and Chemical Toxicology AU - Mei, N AU - Hu, J AU - Churchwell, MI AU - Guo, L AU - Moore, M M AU - Doerge AU - Chen, T AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States, nan.mei@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 628 EP - 636 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 2 SN - 0278-6915, 0278-6915 KW - Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - chromosome 11 KW - DNA adducts KW - Food KW - Genotoxicity KW - Microsatellites KW - Statistical analysis KW - Mutant frequency KW - Loss of heterozygosity KW - Chromosomes KW - Guanine KW - Colonies KW - Acrylamide KW - Adenine KW - Metabolic activation KW - Lymphoma KW - Mutation KW - Occupational exposure KW - F 06955:Immunomodulation & Immunopharmacology KW - N 14820:DNA Metabolism & Structure KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19999113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Genotoxic+effects+of+acrylamide+and+glycidamide+in+mouse+lymphoma+cells&rft.au=Mei%2C+N%3BHu%2C+J%3BChurchwell%2C+MI%3BGuo%2C+L%3BMoore%2C+M+M%3BDoerge%3BChen%2C+T&rft.aulast=Mei&rft.aufirst=N&rft.date=2008-02-01&rft.volume=46&rft.issue=2&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2007.09.093 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA adducts; chromosome 11; Food; Genotoxicity; Statistical analysis; Microsatellites; Mutant frequency; Loss of heterozygosity; Colonies; Guanine; Chromosomes; Acrylamide; Adenine; Metabolic activation; Mutation; Lymphoma; Occupational exposure DO - http://dx.doi.org/10.1016/j.fct.2007.09.093 ER - TY - JOUR T1 - Microbiological Quality of Bagged Cut Spinach and Lettuce Mixes AN - 19789009; 8032781 AB - Analysis of 100 bagged lettuce and spinach samples showed mean total bacterial counts of 7.0 log sub(10) CFU/g and a broad range of <4 to 8.3 log sub(10) CFU/g. Most probable numbers (MPN) of greater than or equal to 11,000 /g coliforms were found in 55 samples, and generic Escherichia coli bacteria were detected in 16 samples, but no E. coli count exceeded 10 MPN/g. JF - Applied and Environmental Microbiology AU - Valentin-Bon, Iris AU - Jacobson, Andrew AU - Monday, Steven R AU - Feng, Peter CH AD - Division of Microbiology, United States Food and Drug Administration, College Park, Maryland 20740 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 1240 EP - 1242 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 4 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Most probable number KW - Coliforms KW - Colony-forming cells KW - Escherichia coli KW - Spinacia oleracea KW - A 01360:Plant Diseases KW - J 02420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19789009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Microbiological+Quality+of+Bagged+Cut+Spinach+and+Lettuce+Mixes&rft.au=Valentin-Bon%2C+Iris%3BJacobson%2C+Andrew%3BMonday%2C+Steven+R%3BFeng%2C+Peter+CH&rft.aulast=Valentin-Bon&rft.aufirst=Iris&rft.date=2008-02-01&rft.volume=74&rft.issue=4&rft.spage=1240&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Coliforms; Most probable number; Colony-forming cells; Escherichia coli; Spinacia oleracea ER - TY - JOUR T1 - The Use of Immunochemical and Biosensor Methods for Occupational and Environmental Monitoring. Part I: Introduction to Immunoassays AN - 19487192; 8502029 AB - Abstract not available. JF - Journal of Occupational and Environmental Hygiene AU - Ashley, Kevin AU - Biagini, Raymond E AU - Smith, Jerry P AU - Sammons, Deborah L AU - MacKenzie, Barbara A AU - Striley, Cynthia A F AU - Robertson, Shirley K AU - Snawder, John E AD - Biomonitoring and Health Assessment Branch, Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - D25 EP - D32 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 5 IS - 2 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Biotechnology and Bioengineering Abstracts; Health & Safety Science Abstracts KW - Environmental monitoring KW - Biosensors KW - Immunoassays KW - Environmental hygiene KW - W 30955:Biosensors KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19487192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=The+Use+of+Immunochemical+and+Biosensor+Methods+for+Occupational+and+Environmental+Monitoring.+Part+I%3A+Introduction+to+Immunoassays&rft.au=Ashley%2C+Kevin%3BBiagini%2C+Raymond+E%3BSmith%2C+Jerry+P%3BSammons%2C+Deborah+L%3BMacKenzie%2C+Barbara+A%3BStriley%2C+Cynthia+A+F%3BRobertson%2C+Shirley+K%3BSnawder%2C+John+E&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2008-02-01&rft.volume=5&rft.issue=2&rft.spage=D25&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620701798182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Biosensors; Environmental monitoring; Immunoassays; Environmental hygiene DO - http://dx.doi.org/10.1080/15459620701798182 ER - TY - JOUR T1 - Urinary hCG patterns during the week following implantation AN - 19466249; 8037318 AB - BACKGROUND: Human chorionic gonadotrophin (hCG) is used to monitor pregnancy status. Yet the pattern of hCG excretion in the first week following implantation has not been adequately described.Therefore the aim of this study was to describe the average profile of hCG and its variability during the 7 days following estimated implantation in a population of naturally conceived pregnancies. METHODS: We measured daily hCG concentrations in first-morning urine for 142 clinical pregnancies from women with no known fertility problems. Mixed-effects regression models were used to estimate the hCG trajectory and its variability in relation to pregnancy outcomes. RESULTS: hCG rose 3-fold between the day of detection and the next day (95% CI = 2.7-3.4). The relative rate of rise decreased thereafter, reaching 1.6-fold (95% CI = 1.5-1.8) between days 6 and 7. HCG levels followed a log-quadratic trajectory, and the patterns of rise were unrelated to number of fetuses, risk of spontaneous abortion or sex of the baby. Later implantations (after 10 luteal days) produced slower rates of increase. CONCLUSIONS: Although mean hCG follows a log-quadratic trajectory during the first week of detectability, there is high variability across pregnancies. Later implantation may reflect characteristics of the uterus or conceptus that slow hCG production. JF - Human Reproduction AU - Nepomnaschy, P A AU - Weinberg, C R AU - Wilcox, A J AU - Baird, D D AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO BOX 12233, MD A3-05, Rm 309, 111 TW Alexander Drive, Research Triangle Park, NC, USA. Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 271 EP - 277 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 2 SN - 0268-1161, 0268-1161 KW - Biotechnology and Bioengineering Abstracts KW - Fertility KW - Uterus KW - Urine KW - Abortion KW - Regression analysis KW - Excretion KW - Pituitary (anterior) KW - Fetuses KW - Pregnancy KW - Models KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19466249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Urinary+hCG+patterns+during+the+week+following+implantation&rft.au=Nepomnaschy%2C+P+A%3BWeinberg%2C+C+R%3BWilcox%2C+A+J%3BBaird%2C+D+D&rft.aulast=Nepomnaschy&rft.aufirst=P&rft.date=2008-02-01&rft.volume=23&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Uterus; Fertility; Urine; Abortion; Regression analysis; Excretion; Pituitary (anterior); Fetuses; Models; Pregnancy ER - TY - JOUR T1 - A new chromogenic agar medium for detection of potentially virulent Yersinia enterocolitica AN - 19298269; 8091386 AB - Several outbreaks of foodborne yersiniosis have been documented and this disease continues to be source of infections transmitted through foods. The selective agars most commonly used to isolate Yersinia enterocolitica in clinical, food and environmental samples, cefsulodin-irgasan-novobiocin (CIN) and MacConkey (MAC) agars, lack the ability to differentiate potentially virulent Y. enterocolitica from other Yersinia that may be present as well as some other bacterial spp. This study proposes the use of an agar medium, Y. enterocolitica chromogenic medium (YeCM), for isolation of potentially virulent Y. enterocolitica. This agar contains cellobiose as the fermentable sugar, a chromogenic substrate and selective inhibitors for suppression of colony formation by many competing bacteria. All strains of potentially virulent Yersinia of biotypes 1B, and biotypes 2-5 formed convex, red bulls-eye colonies on YeCM that were very similar to those described for CIN agar. However, Y. enterocolitica biotype 1A and other related Yersinia formed colonies that were purple/blue on YeCM while they formed typical red bulls-eye colonies on CIN agar. When a mixture of potentially virulent Y. enterocolitica biotype 1B, Y. enterocolitica biotype 1A and 5 other bacterial species was used to artificially contaminate tofu and then spread-plated on three selective agars, Y. enterocolitica biotype 1B colonies were easily distinguished from other strains on YeCM. However, Y. enterocolitica biotype 1B colonies were indistinguishable from many other colonies on CIN and only distinguishable from those of C. freundii on MAC. When colonies were picked and identified from these agars, typical colonies from YeCM were confirmed only as Y. enterocolitica biotype 1B. Typical colonies on CIN and MAC were found to belong to several competing species and biotypes. JF - Journal of Microbiological Methods AU - Weagant, S D AD - Pacific Regional Laboratory Northwest, Bothell, WA 98021-4421, 22201 23rd Dr. S. E., Bothell, WA 98021-4421, United States, steve.weagant@fda.hhs.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 185 EP - 190 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 72 IS - 2 SN - 0167-7012, 0167-7012 KW - Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Environmental monitoring KW - Agar KW - Sugar KW - Biotypes KW - cellobiose KW - Food KW - outbreaks KW - Food contamination KW - Infection KW - Colonies KW - Yersiniosis KW - infection KW - Yersinia enterocolitica KW - biotypes KW - H 4000:Food and Drugs KW - W 30900:Methods KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19298269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microbiological+Methods&rft.atitle=A+new+chromogenic+agar+medium+for+detection+of+potentially+virulent+Yersinia+enterocolitica&rft.au=Weagant%2C+S+D&rft.aulast=Weagant&rft.aufirst=S&rft.date=2008-02-01&rft.volume=72&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microbiological+Methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2007.11.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sugar; Agar; Colonies; Biotypes; Yersiniosis; cellobiose; Food; Infection; Environmental monitoring; infection; outbreaks; Food contamination; biotypes; Yersinia enterocolitica DO - http://dx.doi.org/10.1016/j.mimet.2007.11.019 ER -