TY - JOUR T1 - Method for the isolation and detection of Enterobacter sakazakii (Cronobacter) from powdered infant formula AN - 21052340; 11305386 AB - In the United States, there are approximately 76 million foodborne cases annually. Although the number of food-related infections caused by Enterobacter sakazakii is relatively low, the United States Food and Drug Administration in 2002 became concerned about the incidence of E. sakazakii infections related to powdered infant formula (PIF). At that time, a method to isolate this pathogen from PIF was developed and implemented in several cases. This protocol requires multiple steps and up to 7 days to complete. Recently, a new method was developed that incorporates a real-time PCR-based assay and chromogenic agars to improve isolating and detecting this pathogen in PIF. The updated protocol has undergone and successfully concluded an AOAC pre-collaborative study and is in the process of further validation for the inclusion into the FDA's Bacteriological Analytical Manual. This manuscript describes the performance evaluation of the new method. JF - International Journal of Food Microbiology AU - Lampel, KA AU - Chen, Y AD - Division of Microbiology, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA, Keith.lampel@fda.hhs.gov Y1 - 2009/12/31/ PY - 2009 DA - 2009 Dec 31 SP - 179 EP - 184 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 136 IS - 2 SN - 0168-1605, 0168-1605 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts; Microbiology Abstracts B: Bacteriology KW - infant formulas KW - Agar KW - Infant formulas KW - Enterobacter sakazakii KW - Pathogens KW - Infection KW - USA KW - infection KW - FDA KW - Drugs KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21052340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Method+for+the+isolation+and+detection+of+Enterobacter+sakazakii+%28Cronobacter%29+from+powdered+infant+formula&rft.au=Lampel%2C+KA%3BChen%2C+Y&rft.aulast=Lampel&rft.aufirst=KA&rft.date=2009-12-31&rft.volume=136&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2009.08.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Agar; Infant formulas; Pathogens; Infection; infant formulas; FDA; infection; Drugs; Enterobacter sakazakii; USA DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2009.08.016 ER - TY - JOUR T1 - Prevalence of methicillin-resistant Staphylococcus aureus colonisation in Tasmanian rural hospitals AN - 807286154; 13811919 AB - A point prevalence study was performed to determine the methicillin-resistant Staphylococcus aureus (MRSA) nasal colonisation rates in Tasmanian rural hospital inpatients. Nasal swabs were performed on all Tasmanian rural hospital inpatients hospitalised for more than 48 h before collection. A single swab was collected from both anterior nares and cultured for MRSA. Molecular typing was performed on all MRSA isolated. Demographic and clinical data was collected for each study participant. Data was analysed using the statistical software program SPSS. A total of 185 patients from 14 rural hospitals were included in the study. MRSA was isolated from 13 (7%) patients. Significant differences in MRSA prevalence were found between regions (P < 0.05) and between hospitals (P < 0.05). In the northern region of Tasmania, 11% of rural inpatients were colonised with MRSA, compared with 3 and 0% of rural inpatients in the State's north-west and southern regions, respectively. The presence of an indwelling urinary catheter was associated with a higher risk of MRSA nasal colonisation (P = 0.066). Patient age, gender and duration of hospital admission before the swab was collected were not identified as significant risk factors for MRSA nasal colonisation. Twelve of the 13 MRSA (92%) isolated were characterised as ST22-MRSA-IV (EMRSA-15). There is a higher prevalence of MRSA nasal colonisation in rural hospital inpatients in the northern region of Tasmania compared with other Tasmanian regions. ST22-MRSA-IV may be endemic in at least one northern Tasmanian rural hospital. This information may have implications for future strategies designed to minimise the prevalence and transmission of MRSA in Tasmania. JF - Healthcare Infection AU - Mitchell, Brett AU - McGregor, Alistair AU - Coombs, Geoffrey AD - TIPCU, Department of Health and Human Services, GPO Box 125, Hobart, Tas. 7001, Australia, brett.mitchell@dhhs.tas.gov.au Y1 - 2009/12/21/ PY - 2009 DA - 2009 Dec 21 SP - 159 EP - 163 PB - CSIRO Publishing, PO Box 1139 Collingwood Vic. 3066 Australia VL - 14 IS - 4 SN - 1835-5617, 1835-5617 KW - Microbiology Abstracts B: Bacteriology KW - Age KW - Data processing KW - Statistics KW - Drug resistance KW - Demography KW - Computer programs KW - software KW - Typing KW - Risk factors KW - Catheters KW - Staphylococcus aureus KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807286154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Healthcare+Infection&rft.atitle=Prevalence+of+methicillin-resistant+Staphylococcus+aureus+colonisation+in+Tasmanian+rural+hospitals&rft.au=Mitchell%2C+Brett%3BMcGregor%2C+Alistair%3BCoombs%2C+Geoffrey&rft.aulast=Mitchell&rft.aufirst=Brett&rft.date=2009-12-21&rft.volume=14&rft.issue=4&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Healthcare+Infection&rft.issn=18355617&rft_id=info:doi/10.1071%2FHI09023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Demography; Computer programs; Age; software; Typing; Statistics; Data processing; Risk factors; Drug resistance; Catheters; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1071/HI09023 ER - TY - JOUR T1 - Possible involvement of the hypothalamic pro-opiomelanocortin gene and beta-endorphin expression on acute morphine withdrawal development. AN - 734091611; 19723567 AB - We studied the effects of supraspinally administered morphine on the expression of the hypothalamic pro-opiomelanocortin (POMC) gene and beta-endorphin. Mice were administered morphine intracerebroventricularly (i.c.v.) either once or 5 times for 5 days (once/day). A single morphine administration significantly increased the hypothalamic POMC gene and beta-endorphin expression at 2h after application in dose-dependent fashion; however, repeated morphine administration had no effect on the hypothalamic POMC gene and beta-endorphin expression. In the immunoblot and immunohistochemical study, the increase of beta-endorphin was observed in the arcuate nucleus of the hypothalamus. Moreover, the expressions of c-Fos, phosphorylated calcium/calmodulin-dependent protein kinase-IIalpha (pCaMK-IIalpha), and phosphorylated cAMP response element-binding protein (pCREB) were increased by a single i.c.v. morphine injection at various time points, but the expressions of phosphorylated extracellular signal-regulated protein kinase1/2 (pERK1/2) and phosphorylated IkappaB (pIkappaB) were not. We also found that the expressions of c-Fos, pCaMKIIalpha, and pCREB were co-localized with the POMC expression. Meanwhile, naloxone as well as muscimol and baclofen significantly attenuated the increases of the POMC gene expression induced by a single morphine administration. Furthermore, the pretreatment of muscimol and baclofen 10 min before morphine injection robustly attenuated the withdrawal behavior induced by a single morphine administration. These results imply that the hypothalamic POMC gene and beta-endorphin expression may play an important role in the development of an acute physical dependency of morphine. In that, GABAergic neurotransmission appear to be involved in the regulation of the hypothalamic POMC gene expression induced by supraspinal morphine administration. JF - Brain research bulletin AU - Seo, Young-Jun AU - Kwon, Min-Soo AU - Choi, Seung-Min AU - Lee, Jin-Koo AU - Park, Soo-Hyun AU - Jung, Jun-Sub AU - Sim, Yun-Beom AU - Suh, Hong-Won AD - Advanced Therapy Products Research Division, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, 194 Tongilro, Eunpyeong-gu, Seoul 122-704, Republic of Korea. Y1 - 2009/12/16/ PY - 2009 DA - 2009 Dec 16 SP - 359 EP - 370 VL - 80 IS - 6 KW - GABA Agonists KW - 0 KW - Narcotic Antagonists KW - Narcotics KW - Muscimol KW - 2763-96-4 KW - Naltrexone KW - 5S6W795CQM KW - beta-Endorphin KW - 60617-12-1 KW - Pro-Opiomelanocortin KW - 66796-54-1 KW - Morphine KW - 76I7G6D29C KW - Baclofen KW - H789N3FKE8 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Naltrexone -- administration & dosage KW - Mice, Inbred ICR KW - Arcuate Nucleus of Hypothalamus -- drug effects KW - Dose-Response Relationship, Drug KW - Mice KW - Arcuate Nucleus of Hypothalamus -- metabolism KW - GABA Agonists -- pharmacology KW - Naltrexone -- pharmacology KW - Narcotic Antagonists -- pharmacology KW - Muscimol -- pharmacology KW - Baclofen -- pharmacology KW - Male KW - beta-Endorphin -- genetics KW - Substance Withdrawal Syndrome -- metabolism KW - Hypothalamus -- drug effects KW - beta-Endorphin -- metabolism KW - Hypothalamus -- metabolism KW - Substance Withdrawal Syndrome -- genetics KW - Pro-Opiomelanocortin -- genetics KW - Narcotics -- administration & dosage KW - Morphine -- administration & dosage KW - Narcotics -- pharmacology KW - Pro-Opiomelanocortin -- metabolism KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734091611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research+bulletin&rft.atitle=Possible+involvement+of+the+hypothalamic+pro-opiomelanocortin+gene+and+beta-endorphin+expression+on+acute+morphine+withdrawal+development.&rft.au=Seo%2C+Young-Jun%3BKwon%2C+Min-Soo%3BChoi%2C+Seung-Min%3BLee%2C+Jin-Koo%3BPark%2C+Soo-Hyun%3BJung%2C+Jun-Sub%3BSim%2C+Yun-Beom%3BSuh%2C+Hong-Won&rft.aulast=Seo&rft.aufirst=Young-Jun&rft.date=2009-12-16&rft.volume=80&rft.issue=6&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Brain+research+bulletin&rft.issn=1873-2747&rft_id=info:doi/10.1016%2Fj.brainresbull.2009.08.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-20 N1 - Date created - 2009-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainresbull.2009.08.020 ER - TY - JOUR T1 - Sensitivity of insulin production from encapsulated islets to endotoxin-stimulated macrophage inflammatory mediators AN - 883047543; 15242351 AB - Chronic inflammation may compromise function of implanted encapsulated islets. Increased purity of alginate used for encapsulation prolongs encapsulated graft function, correlating with decreased presence of impurities like bacterial endotoxin. Limits for endotoxin contamination in biomaterials based on indirect inhibition of function of embedded cells have yet to be established. In a coculture system with RAW 264.7 monocyte/macrophage cells in the presence of 50 ng/mL murine recombinant gamma-interferon (mrIFN-), the insulin response to glucose challenge of both rat and pig unencapsulated islets was prevented by endotoxin (LPS) in the medium down to 0.3 EU/mL (LOEL), but not 0.06 EU/mL (NOEL). Evaluation of nitrite concentrations in supernatants revealed that pig islets were more resistant to LPS-stimulated macrophage mediators than rat islets. Encapsulation in highly purified alginate produced little change in observed inhibitory effects of macrophage-generated nitric oxide (NO) toward islet function. Chemically released NO was much less effective in inhibiting insulin responsiveness to glucose challenge than was coculture of islets with LPS and mrIFN-stimulated RAW 264.7. These results taken together with other data suggest that an upper limit of 0.3 EU/mL LPS within the encapsulating alginate will not impair the function of implanted encapsulated islets by toxic concentrations of macrophage-mediated inflammatory agents. [copy 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2009 JF - Journal of Biomedical Materials Research, Part A AU - Lyle, Daniel B AU - Shallcross, Jonathan C AU - Langone, John J Y1 - 2009/12/15/ PY - 2009 DA - 2009 Dec 15 SP - 1221 EP - 1238 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 91A IS - 4 SN - 1552-4965, 1552-4965 KW - Immunology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Macrophages KW - Endotoxins KW - Data processing KW - Contamination KW - Impurities KW - Glucose KW - Islets of Langerhans KW - Insulin KW - Encapsulation KW - Inflammation KW - Alginic acid KW - Biomaterials KW - Lipopolysaccharides KW - Nitric oxide KW - Monocytes KW - Nitrite KW - A 01310:Products of Microorganisms KW - F 06910:Microorganisms & Parasites KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883047543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research%2C+Part+A&rft.atitle=Sensitivity+of+insulin+production+from+encapsulated+islets+to+endotoxin-stimulated+macrophage+inflammatory+mediators&rft.au=Lyle%2C+Daniel+B%3BShallcross%2C+Jonathan+C%3BLangone%2C+John+J&rft.aulast=Lyle&rft.aufirst=Daniel&rft.date=2009-12-15&rft.volume=91A&rft.issue=4&rft.spage=1221&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research%2C+Part+A&rft.issn=15524965&rft_id=info:doi/10.1002%2Fjbm.a.32351 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.32351/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Endotoxins; Macrophages; Data processing; Contamination; Impurities; Glucose; Islets of Langerhans; Insulin; Inflammation; Encapsulation; Alginic acid; Biomaterials; Lipopolysaccharides; Nitric oxide; Monocytes; Nitrite DO - http://dx.doi.org/10.1002/jbm.a.32351 ER - TY - JOUR T1 - In-vitro mapping of E-fields induced near pacemaker leads by simulated MR gradient fields AN - 746198821; 12747134 AB - Magnetic resonance imaging (MRI) of patients with implanted cardiac pacemakers is generally contraindicated but some clinicians condone scanning certain patients. We assessed the risk of inducing unintended cardiac stimulation by measuring electric fields (E) induced near lead tips by a simulated MRI gradient system. The objectives of this study are to map magnetically induced E near distal tips of leads in a saline tank to determine the spatial distribution and magnitude of E and compare them with E induced by a pacemaker pulse generator (PG). We mapped magnetically induced E with 0.1 mm resolution as close as 1 mm from lead tips. We used probes with two straight electrodes (e.g. wire diameter of 0.2 mm separated by 0.9 mm). We generated magnetic flux density (B) with a Helmholtz coil throughout 0.6% saline in a 24 cm diameter tank with (dB/dt) of 1 T/sec (1 kHz sinusoidal waveform). Separately, we measured E near the tip of leads when connected to a PG set to a unipolar mode. Measurements were non-invasive (not altering the leads or PG under study). When scaled to 30 T/s (a clinically relevant value), magnetically-induced E exceeded the E produced by a PG. The magnetically-induced E only occurred when B was coincident with or within 15 msec of implantable pacemaker's pulse. Potentially hazardous situations are possible during an MR scan due to gradient fields. Unintended stimulation can be induced via abandoned leads and leads connected to a pulse generator with loss of hermetic seal at the connector. Also, pacemaker-dependent patients can receive drastically altered pacing pulses. JF - BioMedical Engineering OnLine AU - Bassen, Howard I AU - Mendoza, Gonzalo G AD - Division of Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, FDA, 10903 New Hampshire Avenue Silver Spring, MD 20993-0002, USA Y1 - 2009/12/15/ PY - 2009 DA - 2009 Dec 15 SP - 39 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 8 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Spatial distribution KW - Scanning KW - Electric fields KW - Magnetic resonance imaging KW - Electrodes KW - Probes KW - Pacemakers KW - Mapping KW - Lead KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746198821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMedical+Engineering+OnLine&rft.atitle=In-vitro+mapping+of+E-fields+induced+near+pacemaker+leads+by+simulated+MR+gradient+fields&rft.au=Bassen%2C+Howard+I%3BMendoza%2C+Gonzalo+G&rft.aulast=Bassen&rft.aufirst=Howard&rft.date=2009-12-15&rft.volume=8&rft.issue=&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=BioMedical+Engineering+OnLine&rft.issn=1475-925X&rft_id=info:doi/10.1186%2F1475-925X-8-39 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Heart; Scanning; Spatial distribution; Electric fields; Electrodes; Magnetic resonance imaging; Probes; Mapping; Pacemakers; Lead DO - http://dx.doi.org/10.1186/1475-925X-8-39 ER - TY - JOUR T1 - Size-dependent effects of tungsten carbide-cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells AN - 21206452; 11200232 AB - Hard metal or cemented carbide consists of a mixture of tungsten carbide (WC) (85%) and metallic cobalt (Co) (5-15%). WC-Co is considered to be potentially carcinogenic to humans. However, no comparison of the adverse effects of nano-sized WC-Co particles is available to date. In the present study, we compared the ability of nano- and fine-sized WC-Co particles to form free radicals and propensity to activate the transcription factors, AP-1 and NF-B, along with stimulation of mitogen-activated protein kinase (MAPK) signaling pathways in a mouse epidermal cell line (JB6 P super(+)). Our results demonstrated that nano-WC-Co generated a higher level of hydroxyl radicals, induced greater oxidative stress, as evidenced by a decrease of GSH levels, and caused faster JB6 P super(+) cell growth /proliferation than observed after exposure of cells to fine WC-Co. In addition, nano-WC-Co activated AP-1 and NF-B more efficiently in JB6 super(+) super(/) super(+) cells as compared to fine WC-Co. Experiments using AP-1-luciferase reporter transgenic mice confirmed the activation of AP-1 by nano-WC-Co. Nano- and fine-sized WC-Co particles also stimulated MAPKs, including ERKs, p38, and JNKs with significantly higher potency of nano-WC-Co. Finally, co-incubation of the JB6 super(+) super(/) super(+) cells with N-acetyl-cysteine decreased AP-1 activation and phosphorylation of ERKs, p38 kinase, and JNKs, thus suggesting that oxidative stress is involved in WC-Co-induced toxicity and AP-1 activation. JF - Toxicology and Applied Pharmacology AU - Ding, M AU - Kisin, E R AU - Zhao, J AU - Bowman, L AU - Lu, Y AU - Jiang, B AU - Leonard, S AU - Vallyathan, V AU - Castranova, V AU - Murray, A R AU - Fadeel, B AU - Shvedova, A A AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA, mid5@cdc.gov Y1 - 2009/12/15/ PY - 2009 DA - 2009 Dec 15 SP - 260 EP - 268 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 241 IS - 3 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - Heavy metals KW - tungsten carbide KW - Particulates KW - Tungsten KW - Cell activation KW - Extracellular signal-regulated kinase KW - Phosphorylation KW - Reactive oxygen species KW - Carcinogenicity KW - Oxidative stress KW - Cobalt KW - Metals KW - MAP kinase KW - Free radicals KW - Activator protein 1 KW - Toxicity KW - Transgenic mice KW - oxidative stress KW - Hydroxyl radicals KW - Transcription factors KW - NF-B protein KW - Proteins KW - Cell proliferation KW - Side effects KW - Signal transduction KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21206452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Size-dependent+effects+of+tungsten+carbide-cobalt+particles+on+oxygen+radical+production+and+activation+of+cell+signaling+pathways+in+murine+epidermal+cells&rft.au=Ding%2C+M%3BKisin%2C+E+R%3BZhao%2C+J%3BBowman%2C+L%3BLu%2C+Y%3BJiang%2C+B%3BLeonard%2C+S%3BVallyathan%2C+V%3BCastranova%2C+V%3BMurray%2C+A+R%3BFadeel%2C+B%3BShvedova%2C+A+A&rft.aulast=Ding&rft.aufirst=M&rft.date=2009-12-15&rft.volume=241&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.09.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - MAP kinase; Heavy metals; Free radicals; Activator protein 1; tungsten carbide; Toxicity; Transgenic mice; Cell activation; Tungsten; Extracellular signal-regulated kinase; Reactive oxygen species; Phosphorylation; Oxidative stress; Cobalt; Transcription factors; NF-B protein; Cell proliferation; Side effects; Signal transduction; Metals; Carcinogenicity; Proteins; Particulates; oxidative stress; Hydroxyl radicals DO - http://dx.doi.org/10.1016/j.taap.2009.09.004 ER - TY - JOUR T1 - In silico toxicology for the pharmaceutical sciences AN - 21197737; 11200227 AB - The applied use of in silico technologies (a.k.a. computational toxicology, in silico toxicology, computer-assisted tox, e-tox, i-drug discovery, predictive ADME, etc.) for predicting preclinical toxicological endpoints, clinical adverse effects, and metabolism of pharmaceutical substances has become of high interest to the scientific community and the public. The increased accessibility of these technologies for scientists and recent regulations permitting their use for chemical risk assessment supports this notion. The scientific community is interested in the appropriate use of such technologies as a tool to enhance product development and safety of pharmaceuticals and other xenobiotics, while ensuring the reliability and accuracy of in silico approaches for the toxicological and pharmacological sciences. For pharmaceutical substances, this means active and impurity chemicals in the drug product may be screened using specialized software and databases designed to cover these substances through a chemical structure-based screening process and algorithm specific to a given software program. A major goal for use of these software programs is to enable industry scientists not only to enhance the discovery process but also to ensure the judicious use of in silico tools to support risk assessments of drug-induced toxicities and in safety evaluations. However, a great amount of applied research is still needed, and there are many limitations with these approaches which are described in this review. Currently, there is a wide range of endpoints available from predictive quantitative structure-activity relationship models driven by many different computational software programs and data sources, and this is only expected to grow. For example, there are models based on non-proprietary and/or proprietary information specific to assessing potential rodent carcinogenicity, in silico screens for ICH genetic toxicity assays, reproductive and developmental toxicity, theoretical prediction of human drug metabolism, mechanisms of action for pharmaceuticals, and newer models for predicting human adverse effects. How accurate are these approaches is both a statistical issue and challenge in toxicology. In this review, fundamental concepts and the current capabilities and limitations of this technology will be critically addressed. JF - Toxicology and Applied Pharmacology AU - Valerio, L G AD - Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak 51 Room 4128, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA, Luis.Valerio@fda.hhs.gov Y1 - 2009/12/15/ PY - 2009 DA - 2009 Dec 15 SP - 356 EP - 370 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 241 IS - 3 SN - 0041-008X, 0041-008X KW - Health & Safety Science Abstracts; Environment Abstracts; Toxicology Abstracts KW - Risk assessment KW - Statistics KW - Impurities KW - Algorithms KW - Xenobiotics KW - Computer programs KW - software KW - Carcinogenicity KW - Drugs KW - Toxicology KW - structure-activity relationships KW - Data processing KW - Drug metabolism KW - Toxicity KW - Computer applications KW - Databases KW - Reviews KW - Pharmaceuticals KW - Structure-activity relationships KW - rodents KW - Side effects KW - Metabolism KW - Technology KW - X 24310:Pharmaceuticals KW - H 4000:Food and Drugs KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21197737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=In+silico+toxicology+for+the+pharmaceutical+sciences&rft.au=Valerio%2C+L+G&rft.aulast=Valerio&rft.aufirst=L&rft.date=2009-12-15&rft.volume=241&rft.issue=3&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.08.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Data processing; Statistics; Drug metabolism; Impurities; Algorithms; Xenobiotics; Toxicity; Computer applications; Databases; Computer programs; software; Carcinogenicity; Reviews; Pharmaceuticals; Structure-activity relationships; Drugs; Metabolism; Side effects; structure-activity relationships; rodents; Toxicology; Technology DO - http://dx.doi.org/10.1016/j.taap.2009.08.022 ER - TY - JOUR T1 - Effects of 45-nm silver nanoparticles on coronary endothelial cells and isolated rat aortic rings AN - 21043859; 11324075 AB - This study was undertaken to determine whether silver nanoparticles (Ag-45nm NPs) induce selective and specific biological effects, such as induction of proliferation and nitric oxide (NO) production, and cytotoxicity in coronary endothelial cells (CECs), and regulation of vascular tone in isolated rat aortic rings. Physical characterization of Ag-45nm NPs by transmission electron microscopy (TEM) demonstrated that nanoparticles ranging in size from 10 to 90nm had biological effects on CECs. Increasing concentrations of Ag-45nm NPs exerted a dual effect on cell proliferation whereby proliferation was inhibited at low concentrations of NPs and stimulated at high concentrations. The effects of high, but not low, concentrations of Ag-45nm NPs were dependent on NO because the effects were partially blocked by N super(G)-nitro-l-arginine methyl ester (L-NAME). We have also shown that high, but not low, concentrations of Ag-45nm NPs induce NO-dependent proliferation through activation of endothelial nitric oxide synthase (eNOS) by phosphorylation of Serine 1177. Moreover, the antiproliferative and proliferative effects of Ag-45nm NPs were concentration-dependent and inversely correlated with cellular toxicity. In isolated rat aortic rings, a low concentration of NPs induced vasoconstriction and a high concentration stimulated vasodilation. The physiologic effects induced by a low concentration of Ag-45nm NPs inhibited acetylcholine- (ACh-) induced NO-mediated relaxation. Vasodilation induced by a high concentration of NPs was partially abolished by L-NAME pretreatment. When the endothelium was removed from the rings, all physiologic responses were blocked. These results clearly demonstrate that the NPs have selective and specific effects on the vascular endothelium in a concentration-dependent manner and suggest that opposite effects could be associated with NPs of different sizes. JF - Toxicology Letters AU - Rosas-Hernandez, H AU - Jimenez-Badillo, S AU - Martinez-Cuevas, P P AU - Gracia-Espino, E AU - Terrones, H AU - Terrones, M AU - Hussain, S M AU - Ali, S F AU - Gonzalez, C AD - Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR, USA, Syed.ali@fda.hhs.gov Y1 - 2009/12/15/ PY - 2009 DA - 2009 Dec 15 SP - 305 EP - 313 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 191 IS - 2-3 SN - 0378-4274, 0378-4274 KW - Environment Abstracts; Toxicology Abstracts KW - biological effects KW - Transmission electron microscopy KW - Endothelial cells KW - Phosphorylation KW - Vasodilation KW - Endothelium KW - Serine KW - Vascular system KW - NG-Nitroarginine methyl ester KW - Aorta KW - Vasoconstriction KW - Toxicity KW - Esters KW - Nitric-oxide synthase KW - Cytotoxicity KW - Microscopy KW - Nitric oxide KW - Cell proliferation KW - Silver KW - nanoparticles KW - X 24310:Pharmaceuticals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21043859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Effects+of+45-nm+silver+nanoparticles+on+coronary+endothelial+cells+and+isolated+rat+aortic+rings&rft.au=Rosas-Hernandez%2C+H%3BJimenez-Badillo%2C+S%3BMartinez-Cuevas%2C+P+P%3BGracia-Espino%2C+E%3BTerrones%2C+H%3BTerrones%2C+M%3BHussain%2C+S+M%3BAli%2C+S+F%3BGonzalez%2C+C&rft.aulast=Rosas-Hernandez&rft.aufirst=H&rft.date=2009-12-15&rft.volume=191&rft.issue=2-3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2009.09.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - NG-Nitroarginine methyl ester; Aorta; Transmission electron microscopy; Vasoconstriction; Toxicity; Nitric-oxide synthase; Endothelial cells; Cytotoxicity; Phosphorylation; Vasodilation; Endothelium; Nitric oxide; Cell proliferation; nanoparticles; Silver; Serine; Vascular system; biological effects; Microscopy; Esters DO - http://dx.doi.org/10.1016/j.toxlet.2009.09.014 ER - TY - CPAPER T1 - Perinatal Development of Metabolic and Physiological Systems Can Affect the Pharmacokinetics of Endocrine-Active Compounds in Rodents and Non-Human Primates T2 - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AN - 42283270; 5622951 JF - 2009 International Conference on Fetal Programming and Developmental Toxicity (PPTOXII) AU - Doerge, Daniel Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - Pharmacokinetics KW - Primates KW - Rodents KW - Physiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42283270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.atitle=Perinatal+Development+of+Metabolic+and+Physiological+Systems+Can+Affect+the+Pharmacokinetics+of+Endocrine-Active+Compounds+in+Rodents+and+Non-Human+Primates&rft.au=Doerge%2C+Daniel&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+International+Conference+on+Fetal+Programming+and+Developmental+Toxicity+%28PPTOXII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/CCT_pptox_meeting.asp#program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Premature Births in Israel 2000-2007 T2 - The Fourth International Jerusalem Conference on Health Policy AN - 42228832; 5596205 JF - The Fourth International Jerusalem Conference on Health Policy AU - Rubin, Lisa AU - Fisher, Nirah AU - Yehoshua, Maggi AU - Uliel, Aviva AU - Gordon, Ethel-Sherry AU - Haklai, Ziona Y1 - 2009/12/07/ PY - 2009 DA - 2009 Dec 07 KW - Israel KW - Birth KW - Parturition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42228832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=The+Fourth+International+Jerusalem+Conference+on+Health+Policy&rft.atitle=Premature+Births+in+Israel+2000-2007&rft.au=Rubin%2C+Lisa%3BFisher%2C+Nirah%3BYehoshua%2C+Maggi%3BUliel%2C+Aviva%3BGordon%2C+Ethel-Sherry%3BHaklai%2C+Ziona&rft.aulast=Rubin&rft.aufirst=Lisa&rft.date=2009-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=The+Fourth+International+Jerusalem+Conference+on+Health+Policy&rft.issn=&rft_id=info:doi/ L2 - http://www.israelhpr.org.il/FileServer/621a21ce6481635a04e952f9bafb637 8.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fundamentals of Cardiovascular Device Regulation: Meeting FDA's Mission and Making the Process Work T2 - 2009 Meeting on Innovations in Cardiovascular Interventions (ICI 2009) AN - 42261922; 5617069 JF - 2009 Meeting on Innovations in Cardiovascular Interventions (ICI 2009) AU - Farb, Andrew Y1 - 2009/12/06/ PY - 2009 DA - 2009 Dec 06 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42261922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Meeting+on+Innovations+in+Cardiovascular+Interventions+%28ICI+2009%29&rft.atitle=Fundamentals+of+Cardiovascular+Device+Regulation%3A+Meeting+FDA%27s+Mission+and+Making+the+Process+Work&rft.au=Farb%2C+Andrew&rft.aulast=Farb&rft.aufirst=Andrew&rft.date=2009-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Meeting+on+Innovations+in+Cardiovascular+Interventions+%28ICI+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congress.co.il/ici2009/images/stories/last_program_ici_06.1 2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Commercial Drivers' Health: A Naturalistic Study of Body Mass Index, Fatigue, and Involvement in Safety-Critical Events AN - 853484791; 14138380 AB - Objective: To explore the relation of commercial truck drivers' body mass indexex (BMI) to fatigued driving episodes and involvement in safety-critical events. Methods: One hundred and three professional truck drivers participated in a long-term naturalistic (on-road) driving study whereby vehicle motion data as well as video of the driver and driving environment were gathered continuously. This data set was analyzed to identify safety-critical events as well as fatigued driving episodes using two independent measures of fatigue. Odds ratio analyses were then performed to explore the relative risk of driving while fatigued and involvement in safety-critical events based on driver's BMI classification (obese versus non-obese). Results: Results indicated that of the 103 participating truck drivers, 53.4 percent were obese based on BMI. Odds ratio calculations revealed that obese individuals were between 1.22 (CI = 1.03-1.45) and 1.69 times (CI = 1.32-2.18) more likely than non-obese individuals to be rated as fatigued based on the two measures of fatigue. Other analyses showed that obese individuals were at 1.37 times (CI = 1.19-1.59) greater risk for involvement in a safety-critical event than non-obese individuals. Finally, one of the fatigue measures showed that obese individuals were 1.99 times (CI = 1.02-3.88) more likely than non-obese individuals to be fatigued while involved in an at-fault safety-critical incident. Conclusion: The results of this study support other research in the field of health and well-being that indicate a link between obesity and fatigue, which is a major safety issue surrounding commercial motor vehicle operations given the long hours these drivers spend on the road. JF - Traffic Injury Prevention AU - Wiegand, Douglas M AU - Hanowski, Richard J AU - McDonald, Shelby E AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 573 EP - 579 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 10 IS - 6 SN - 1538-9588, 1538-9588 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - Motor vehicles KW - obesity KW - fatigue KW - traffic KW - body mass KW - classification KW - prevention KW - Trucks KW - H 2000:Transportation KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853484791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic+Injury+Prevention&rft.atitle=Commercial+Drivers%27+Health%3A+A+Naturalistic+Study+of+Body+Mass+Index%2C+Fatigue%2C+and+Involvement+in+Safety-Critical+Events&rft.au=Wiegand%2C+Douglas+M%3BHanowski%2C+Richard+J%3BMcDonald%2C+Shelby+E&rft.aulast=Wiegand&rft.aufirst=Douglas&rft.date=2009-12-01&rft.volume=10&rft.issue=6&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Traffic+Injury+Prevention&rft.issn=15389588&rft_id=info:doi/10.1080%2F15389580903295277 L2 - http://www.informaworld.com/smpp/content~db=all~content=a916865759~frm=abslink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - traffic; Injuries; body mass; Motor vehicles; classification; obesity; prevention; Trucks; fatigue DO - http://dx.doi.org/10.1080/15389580903295277 ER - TY - JOUR T1 - Ability of Two Natural Products, Nootkatone and Carvacrol, to Suppress Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) in a Lyme Disease Endemic Area of New Jersey AN - 839688375; 14071465 AB - We evaluated the ability of the natural, plant-derived acaricides nootkatone and carvacrol to suppress Ixodes scapularis Say and Amblyomma americanum (L.) (Acari: Ixodidae). Aqueous formulations of 1 and 5% nootkatone applied by backpack sprayer to the forest litter layer completely suppressed I. scapularis nymphs through 2 d. Thereafter, the level of reduction gradually declined to less than or equal to 50% at 28 d postapplication. Against A. americanum nymphs, 1% nootkatone was less effective, but at a 5% concentration, the level of control was similar or greater to that observed with I. scapularis through 21 d postapplication. Initial applications of 0.05% carvacrol were ineffective, but a 5% carvacrol formulation completely suppressed nymphs of both species through 2 d and resulted in significant reduction in I. scapularis and A. americanum nymphs through 28 and 14 d postapplication, respectively. Backpack sprayer applications of 5% nootkatone to the shrub and litter layers resulted in 100% control of I. scapularis adults through 6 d, but the level of reduction declined to 71.5% at 28 d postapplication. By contrast, high-pressure applications of 2% nootkatone to the litter layer resulted in 96.2-100% suppression of both I. scapularis and A. americanum nymphs through 42 d, whereas much lower control was obtained from the same formulation applied by backpack sprayer. Backpack sprayer application of a 3.1% nootkatone nanoemulsion resulted in 97.5-98.9 and 99.3-100% reduction in I. scapularis and A. americanum nymphs, respectively, at 1 d postapplication. Between 7 d and 35 d postapplication, the level of control varied between 57.1% and 92.5% for I. scapularis and between 78.5 and 97.1% for A. americanum nymphs. The ability of natural products to quickly suppress and maintain significant control of populations of these medically important ticks at relatively low concentrations may represent a future alternative to the use of conventional synthetic acaricides. JF - Journal of Economic Entomology AU - Dolan, Marc C AU - Jordan, Robert A AU - Schulze, Terry L AU - Schulze, Christopher J AU - Manning, Mark Cornell AU - Ruffolo, Daniel AU - Schmidt, Jason P AU - Piesman, Joseph AU - Karchesy, Joseph J AD - Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 3150 Rampart Rd., Fort Collins, CO 80521. Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 2316 EP - 2324 PB - Entomological Society of America, 9301 Annapolis Rd. Lanham MD 20706 USA VL - 102 IS - 6 SN - 0022-0493, 0022-0493 KW - Entomology Abstracts; Microbiology Abstracts B: Bacteriology KW - Acaricides KW - Carvacrol KW - Forests KW - Litter KW - Lyme disease KW - Plants KW - natural products KW - Ixodes KW - Amblyomma KW - Ixodidae KW - Ixodes scapularis KW - Amblyomma americanum KW - Borrelia KW - Acari KW - J 02410:Animal Diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839688375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Economic+Entomology&rft.atitle=Ability+of+Two+Natural+Products%2C+Nootkatone+and+Carvacrol%2C+to+Suppress+Ixodes+scapularis+and+Amblyomma+americanum+%28Acari%3A+Ixodidae%29+in+a+Lyme+Disease+Endemic+Area+of+New+Jersey&rft.au=Dolan%2C+Marc+C%3BJordan%2C+Robert+A%3BSchulze%2C+Terry+L%3BSchulze%2C+Christopher+J%3BManning%2C+Mark+Cornell%3BRuffolo%2C+Daniel%3BSchmidt%2C+Jason+P%3BPiesman%2C+Joseph%3BKarchesy%2C+Joseph+J&rft.aulast=Dolan&rft.aufirst=Marc&rft.date=2009-12-01&rft.volume=102&rft.issue=6&rft.spage=2316&rft.isbn=&rft.btitle=&rft.title=Journal+of+Economic+Entomology&rft.issn=00220493&rft_id=info:doi/10.1603%2F029.102.0638 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Number of references - 39 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Carvacrol; Litter; Plants; Forests; natural products; Acaricides; Lyme disease; Ixodes; Amblyomma americanum; Amblyomma; Ixodidae; Borrelia; Ixodes scapularis; Acari DO - http://dx.doi.org/10.1603/029.102.0638 ER - TY - JOUR T1 - Reconciling longwall gob gas reservoirs and venthole production performances using multiple rate drawdown well test analysis AN - 756290831; 2010-081964 AB - Longwall mining is an underground mining method during which a mechanical shearer progressively mines a large block of coal, called a panel, in an extensive area. During this operation the roof of the coal seam is supported only temporarily with hydraulic supports that protect the workers and the equipment on the coal face. As the coal is extracted, the supports automatically advance and the roof strata cave behind the supports. Caving results in fracturing and relaxation of the overlying strata, which is called "gob." Due its highly fractured nature, gob contains many flow paths for gas migration. Thus, if the overlying strata contain gassy sandstones or sandstone channels, gas shales or thinner coal seams which are not suitable for mining, then the mining-induced changes can cause unexpected or uncontrolled gas migration into the underground workplace. Vertical gob gas ventholes (GGV) are drilled into each longwall panel to capture the methane within the overlying fractured strata before it enters the work environment. Thus, it is important, first to understand the properties of the gas reservoir created by mining disturbances and, second, to optimize the well parameters and placement accordingly. In this paper, the production rate-pressure behaviors of six GGVs drilled over three adjacent panels were analyzed by using conventional multi-rate drawdown analysis techniques. The analyses were performed for infinite acting and pseudo-steady state flow models, which may be applicable during panel mining (DM) and after mining (AM) production periods of GGVs. These phases were analyzed separately since the reservoir properties, due to dynamic subsidence, boundary conditions and gas capacity of the gob reservoir may change between these two stages. The results suggest that conventional well test analysis techniques can be applicable to highly complex gob reservoirs and GGVs to determine parameters such as skin, permeability, radius of investigation, flow efficiency and damage ratio. The insights obtained from well test analyses can be used for a better understanding of the gob and for designing more effective gob gas venthole systems. JF - International Journal of Coal Geology AU - Karacan, C Ozgen Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 181 EP - 195 PB - Elsevier, Amsterdam VL - 80 IS - 3-4 SN - 0166-5162, 0166-5162 KW - United States KW - stratigraphy KW - mining KW - mines KW - overburden KW - monitoring KW - underground mining KW - natural gas KW - coal mines KW - petroleum KW - production KW - rock mechanics KW - gases KW - ventilation KW - sedimentary rocks KW - safety KW - longwall mining KW - boreholes KW - mining geology KW - coal KW - coalbed methane KW - testing KW - Pennsylvania KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756290831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Reconciling+longwall+gob+gas+reservoirs+and+venthole+production+performances+using+multiple+rate+drawdown+well+test+analysis&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2009-12-01&rft.volume=80&rft.issue=3-4&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2009.09.006 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - Number of references - 39 N1 - Document feature - illus. incl. 15 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - boreholes; coal; coal mines; coalbed methane; gases; longwall mining; mines; mining; mining geology; monitoring; natural gas; overburden; Pennsylvania; petroleum; production; rock mechanics; safety; sedimentary rocks; stratigraphy; testing; underground mining; United States; ventilation DO - http://dx.doi.org/10.1016/j.coal.2009.09.006 ER - TY - JOUR T1 - Transfusion-transmitted babesiosis in the United States: summary of a workshop AN - 754896695; 13530039 AB - Infections of humans with intraerythrocytic parasites of the genus Babesia can be locally prevalent in diverse regions of the United States. Transfusion of blood and blood products collected from donors infected with Babesia may result in a serious illness that can be fatal. In September 2008, the Food and Drug Administration organized a public workshop to discuss the various aspects of transfusion-transmitted babesiosis in the United States including the possible strategies to identify and defer blood donors who may have been infected with Babesia. Discussions were also held on the biology, pathogenesis, and epidemiology of Babesia species. In this article, we summarize the scientific presentations and panel discussions that took place during the workshop. JF - Transfusion AU - Gubernot, Diane M AU - Nakhasi, Hira L AU - Mied, Paul A AU - Asher, David M AU - Epstein, Jay S AU - Kumar, Sanjai AD - From the Office of Blood Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland. Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 2759 EP - 2771 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 49 IS - 12 SN - 0041-1132, 0041-1132 KW - Health & Safety Science Abstracts KW - Parasites KW - USA KW - blood donors KW - infection KW - Babesia KW - transfusion KW - Drugs KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754896695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Transfusion-transmitted+babesiosis+in+the+United+States%3A+summary+of+a+workshop&rft.au=Gubernot%2C+Diane+M%3BNakhasi%2C+Hira+L%3BMied%2C+Paul+A%3BAsher%2C+David+M%3BEpstein%2C+Jay+S%3BKumar%2C+Sanjai&rft.aulast=Gubernot&rft.aufirst=Diane&rft.date=2009-12-01&rft.volume=49&rft.issue=12&rft.spage=2759&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2009.02429.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Number of references - 27 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Parasites; blood donors; infection; transfusion; Drugs; Babesia; USA DO - http://dx.doi.org/10.1111/j.1537-2995.2009.02429.x ER - TY - JOUR T1 - In Vitro Dissolution Testing with Flow-Through Method: A Technical Note AN - 754549315; 13306660 AB - Abstract not available. JF - AAPS PharmSciTech AU - Gao, Zongming AD - Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St. Louis, Missouri 63101, USA, zongming.gao@fda.hhs.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1401 EP - 1405 PB - Springer New York LLC VL - 10 IS - 4 SN - 1530-9932, 1530-9932 KW - Biotechnology and Bioengineering Abstracts KW - Dissolution KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754549315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+PharmSciTech&rft.atitle=In+Vitro+Dissolution+Testing+with+Flow-Through+Method%3A+A+Technical+Note&rft.au=Gao%2C+Zongming&rft.aulast=Gao&rft.aufirst=Zongming&rft.date=2009-12-01&rft.volume=10&rft.issue=4&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=AAPS+PharmSciTech&rft.issn=15309932&rft_id=info:doi/10.1208%2Fs12249-009-9339-6 L2 - http://www.springerlink.com/content/g46n3335j9517551/?p=d5f6cd244f5747b3a4364c8285c23707&pi=39 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Dissolution DO - http://dx.doi.org/10.1208/s12249-009-9339-6 ER - TY - RPRT T1 - Truck Driver Buried by Mulch at Town Solid Waste Site AN - 746169456; 13109902 AB - In September 2006, an adult truck driver employed by a trucking company sustained fatal injuries after being buried by mulch in his trailer at a town solid waste site. At the time of the incident, the victim's tractor trailer was being loaded with mulch. The trailer was equipped with a walking floor unloading system. New York State Fatality Assessment and Control Evaluation (NY FACE) investigators concluded that to help prevent similar incidents from occurring in the future, owners of solid waste facilities should: develop and enforce a standard safe loading/unloading procedure for both facility personnel and visiting drivers; and provide frequent training for all facility personnel on the standard safe loading/unloading procedure. In addition, trucking companies should: develop standard safe trailer cleaning procedures and require all drivers to strictly follow the procedures; and provide frequent employee training to ensure that the truck drivers understand and follow site specific safety procedures while picking up or delivering cargos at solid waste facilities. JF - Truck Driver Buried by Mulch at Town Solid Waste Site. [np]. Dec 2009. AU - Anonymous Y1 - 2009/12// PY - 2009 DA - Dec 2009 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - solid wastes KW - mulches KW - Training KW - USA, New York KW - towns KW - Trucks KW - Agricultural equipment KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746169456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Truck+Driver+Buried+by+Mulch+at+Town+Solid+Waste+Site&rft.title=Truck+Driver+Buried+by+Mulch+at+Town+Solid+Waste+Site&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - A Painter Falls 12 Feet While Painting a Pump Hose Platform System - Massachusetts AN - 746164976; 13109898 AB - On May 12, 2007, a 37-year-old male immigrant worker (victim) was fatally injured when he fell while painting a fixed raised pump hose platform system located in a loading dock area. He was an employee of a painting contractor hired to paint the platform system by the platform's owner, an agricultural cooperative that specializes in manufacturing juice. The victim was on one of the platform system's gangways when the gangway lowered causing him to lose his balance and fall approximately 12 feet to a concrete floor below. Emergency medical services (EMS) and the local police department were called by an employee of the agricultural cooperative. EMS and the local police department arrived within minutes. EMS transported the victim to a local hospital where he was pronounced dead. The Massachusetts FACE Program concluded that to prevent similar occurrences in the future, employers should: Ensure that fall protection and relevant training are provided to employees who are exposed to fall hazards when working six feet or more above a lower level. Companies and outside contractors hired to paint equipment/machinery should: Conduct a joint job safety analysis (JSA) of the work area and tasks to be performed to ensure worker safety. JF - A Painter Falls 12 Feet While Painting a Pump Hose Platform System - Massachusetts. [np]. Dec 2009. AU - Anonymous Y1 - 2009/12// PY - 2009 DA - Dec 2009 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Contracts KW - Concrete KW - police KW - Machinery KW - cooperatives KW - Occupational exposure KW - USA, Massachusetts KW - immigrants KW - Training KW - Pumps KW - emergency medical services KW - Paints KW - Hospitals KW - H 13000:Medical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Painter+Falls+12+Feet+While+Painting+a+Pump+Hose+Platform+System+-+Massachusetts&rft.title=A+Painter+Falls+12+Feet+While+Painting+a+Pump+Hose+Platform+System+-+Massachusetts&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Construction Laborer Dies after Falling off Collapsed Precast Concrete Floor Slab AN - 746164226; 13109901 AB - In February 2007, an adult male construction laborer (the victim) sustained fatal injuries after falling off a collapsed precast concrete floor slab at a ten-story building construction site. A concrete floor slab was 26' (feet) 5 one half " (inches) long, 8'3" wide and 8" thick, and weighed approximately seven tons. The floor slabs were positioned on the building's steel structural frame composed of vertical steel columns and horizontal steel beams. The slabs were not secured to the steel framework at the time of the incident. New York State Fatality Assessment and Control Evaluation (NY FACE) investigators recommend the following measures to help prevent similar incidents from occurring in the future, employers should: comply with the structural dimensions and tolerances specified by the erection design and check vertical and horizontal alignment of the steel structural frame before erecting any precast slabs; ensure that workers use personal fall protection arrest systems when working on the precast concrete floor slabs that are not permanently secured to the steel framework; provide employees with training on the prevention of fall hazards associated with working on the unsecured precast concrete floor slabs; and secure the precast slabs to the steel structural frame by the method specified in the erection plan as soon as the slabs are erected. JF - Construction Laborer Dies after Falling off Collapsed Precast Concrete Floor Slab. [np]. Dec 2009. AU - Anonymous Y1 - 2009/12// PY - 2009 DA - Dec 2009 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - arrests KW - Training KW - Concrete KW - USA, New York KW - falls KW - prevention KW - Steel KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Construction+Laborer+Dies+after+Falling+off+Collapsed+Precast+Concrete+Floor+Slab&rft.title=Construction+Laborer+Dies+after+Falling+off+Collapsed+Precast+Concrete+Floor+Slab&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Crane Boom Collapse Kills Man during Disassembling AN - 746164157; 13109900 AB - In March 2008, an adult male (the victim) sustained fatal injuries when the crane boom he was disassembling buckled and crushed him. The truck-mounted lattice boom crane belonged to the owner of a construction company (the owner), who was a friend of the victim. The victim was not an employee of the construction company. At the time of the incident, the victim was at the owner's yard assisting him in disassembling the boom. The boom was 55 feet long and composed of four sections: a base (15 feet), boom extension I (20 feet), boom extension II (10 feet) and a tip with the hook (10 feet). New York State Fatality Assessment and Control Evaluation (NY FACE) investigators concluded that to help prevent similar incidents from occurring in the future, employers should: ensure that all personnel assigned to assemble/disassemble or assist in assembling/disassembling a crane boom receive training on safe assembly/disassembly procedures; ensure that all personnel who are assigned to assemble/disassemble crane booms strictly follow the manufacturer's assembly/disassembly procedures and use blocking to support all boom sections; consult the manufacturer for updated operating and maintenance procedures and safe work practices when using older crane models; and instruct workers to insert the connecting pins with the cotter pins placed on the outside of the boom during crane assembly so that no worker has to get under the boom to remove the cotter pins during disassembly. JF - Crane Boom Collapse Kills Man during Disassembling. [np]. Dec 2009. AU - Anonymous Y1 - 2009/12// PY - 2009 DA - Dec 2009 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Mortality KW - Training KW - Maintenance KW - USA, New York KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Ventral+tegmental+glutamate%3A+a+role+in+stress-%2C+cue-%2C+and+cocaine-induced+reinstatement+of+cocaine-seeking.&rft.au=Wise%2C+Roy+A&rft.aulast=Wise&rft.aufirst=Roy&rft.date=2009-01-01&rft.volume=56+Suppl+1&rft.issue=&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/10.1016%2Fj.neuropharm.2008.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Excessive longitudinal FEV1 decline and risks to future health: A case-control study AN - 745630978; 12739867 AB - Background Accelerated loss of forced expiratory volume in 1 s (FEV1) in an individual is considered an indicator of developing lung disease. Methods We investigated longitudinal FEV1 slopes, calculated by simple linear regression, and adverse health outcomes after 10-30 years, among 1,428 chemical plant workers. Cases were defined by FEV1 slopes below 5th percentile values for the cohort. Cases were matched with controls (107 pairs) for race, gender, smoking status, year of birth, age, height, and calendar year at first test. Matched pair statistics were used for comparisons. Results Cases had a higher proportion, compared to controls, of diagnosis of COPD or emphysema (17.8% vs. 1.9%, P = 0.0002), medication use for respiratory diseases (24.3% vs. 4.7%, P < 0.0001), dyspnea (15% vs. 3.7%, P = 0.0042), and wheezing or rhonchi on examination (10.3% vs. 1.9%, P = 0.0225). Conclusions Chemical plant workers who experienced accelerated FEV1 declines experienced four to nine times as many adverse health conditions over 10-30 years. Am. J. Ind. Med. 52:909-915, 2009. JF - American Journal of Industrial Medicine AU - Wang, Mei Lin AU - Avashia, Bipin H AU - Wood, John AU - Petsonk, Edward L AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Morgantown, West Virginia, elp2@cdc.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 909 EP - 915 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 52 IS - 12 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Smoking KW - Age KW - Gender KW - Respiratory diseases KW - Chemical plants KW - Drugs KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745630978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Excessive+longitudinal+FEV1+decline+and+risks+to+future+health%3A+A+case-control+study&rft.au=Wang%2C+Mei+Lin%3BAvashia%2C+Bipin+H%3BWood%2C+John%3BPetsonk%2C+Edward+L&rft.aulast=Wang&rft.aufirst=Mei&rft.date=2009-12-01&rft.volume=52&rft.issue=12&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20764 L2 - http://www3.interscience.wiley.com/journal/122659661/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Smoking; Age; Gender; Respiratory diseases; Chemical plants; Drugs DO - http://dx.doi.org/10.1002/ajim.20764 ER - TY - JOUR T1 - Frequency dependence of average phase shift from human calcaneus in vitro. AN - 742785522; pmid-20000943 AB - If dispersion in a medium is weak and approximately linear with frequency (over the experimental band of frequencies), then it can be shown that the constant term in a polynomial representation of phase shift as a function of frequency can produce errors in measurements of phase-velocity differences in through-transmission, substitution experiments. A method for suppressing the effects of the constant phase shift in the context of the single-wave-model was tested on measurements from 30 cancellous human calcaneus samples in vitro. Without adjustment for constant phase shifts, the estimated phase velocity at 500 kHz was 1516+/-6 m/s (mean+/-standard error), and the estimated dispersion was -24+/-4 m/s MHz (mean+/-standard error). With adjustment for constant phase shifts, the estimated mean velocity decreased by 4-9 m/s, and the estimated magnitude of mean dispersion decreased by 50%-100%. The average correlation coefficient between the measured attenuation coefficient and frequency was 0.997+/-0.0026 (mean+/-standard deviation), suggesting that the signal for each sample was dominated by one wave. A single-wave, linearly dispersive model conformed to measured complex transfer functions from the 30 cancellous-bone samples with an average root-mean-square error of 1.9%+/-1.0%. JF - The Journal of the Acoustical Society of America AU - Wear, Keith A AD - Center for Devices and Radiological Health, U. S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. keith.wear@fda.hhs.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 3291 EP - 3300 VL - 126 IS - 6 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Phantoms, Imaging KW - Polycarboxylate Cement KW - Humans KW - Linear Models KW - Algorithms KW - Least-Squares Analysis KW - Nylons KW - Calcaneus -- ultrasonography KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742785522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Frequency+dependence+of+average+phase+shift+from+human+calcaneus+in+vitro.&rft.au=Wear%2C+Keith+A&rft.aulast=Wear&rft.aufirst=Keith&rft.date=2009-12-01&rft.volume=126&rft.issue=6&rft.spage=3291&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. AN - 734154062; 19773279 AB - Benzene is an established human haematotoxin, with substantial interindividual variation in benzene-induced toxicity. To further examine if genetic variation contributes to benzene haematotoxicity, we analysed 1023 tagSNPs in 121 gene regions important for benzene metabolism, haematopoiesis, leukaemia and lymphoma among 250 workers exposed to benzene and 140 unexposed controls in a cross-sectional study carried out in China. Linear regression was used to analyse the relationship between genetic polymorphisms and total white blood cell (WBC) count and its subtypes, adjusting for potential confounders and occupational exposure to benzene and toluene among exposed workers. The minp test assessed the association on the gene region level. The false discovery rate method was used to control for multiple comparisons. VEGF (minp = 0.0030) and ERCC3 (minp = 0.0042) were the most significantly associated gene regions with altered WBC counts among benzene-exposed workers, after accounting for multiple comparisons. Highly significant changes were also found for WBC subtype counts, including granulocytes, CD4+ T cells and lymphocytes for VEGF and granulocytes and NK cells for ERCC3. Further, in workers exposed to <1 ppm, a SNP in VEGF was associated with changes in WBC and granulocyte counts, and SNPs in ERCC3 were associated with changes in WBC, NK cell and granulocyte counts. Our findings suggest that genetic variation in VEGF, which plays an important role in blood vessel growth, and ERCC3, which is a member of the DNA repair pathway and is responsible for repairing bulky DNA adducts formed by chemicals, may contribute to individual susceptibility to benzene-induced haematotoxicity at relatively low levels of benzene exposure. JF - Occupational and environmental medicine AU - Hosgood, H D AU - Zhang, L AU - Shen, M AU - Berndt, S I AU - Vermeulen, R AU - Li, G AU - Yin, S AU - Yeager, M AU - Yuenger, J AU - Rothman, N AU - Chanock, S AU - Smith, M AU - Lan, Q AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7240, USA. hosgoodd@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 848 EP - 853 VL - 66 IS - 12 KW - DNA-Binding Proteins KW - 0 KW - VEGFA protein, human KW - Vascular Endothelial Growth Factor A KW - XPBC-ERCC-3 protein KW - 146045-44-5 KW - DNA Helicases KW - EC 3.6.4.- KW - Benzene KW - J64922108F KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Occupational Exposure -- adverse effects KW - Genetic Predisposition to Disease KW - Occupational Exposure -- analysis KW - Male KW - Leukocyte Count KW - Female KW - Leukocytes -- drug effects KW - Hematologic Diseases -- genetics KW - Hematologic Diseases -- chemically induced KW - Occupational Diseases -- genetics KW - Occupational Diseases -- blood KW - Hematologic Diseases -- blood KW - DNA-Binding Proteins -- genetics KW - DNA Helicases -- genetics KW - Benzene -- toxicity KW - Occupational Diseases -- chemically induced KW - Vascular Endothelial Growth Factor A -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734154062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Association+between+genetic+variants+in+VEGF%2C+ERCC3+and+occupational+benzene+haematotoxicity.&rft.au=Hosgood%2C+H+D%3BZhang%2C+L%3BShen%2C+M%3BBerndt%2C+S+I%3BVermeulen%2C+R%3BLi%2C+G%3BYin%2C+S%3BYeager%2C+M%3BYuenger%2C+J%3BRothman%2C+N%3BChanock%2C+S%3BSmith%2C+M%3BLan%2C+Q&rft.aulast=Hosgood&rft.aufirst=H&rft.date=2009-12-01&rft.volume=66&rft.issue=12&rft.spage=848&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foem.2008.044024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-04 N1 - Date created - 2009-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 1989 Jul;82:31-5 [2792049] Biometrics. 1986 Mar;42(1):121-30 [3719049] Nature. 1995 Jul 6;376(6535):62-6 [7596435] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Int J Hematol. 1995 Dec;62(4):203-15 [8589366] Nature. 1996 Apr 4;380(6573):435-9 [8602241] Nature. 1996 Apr 4;380(6573):439-42 [8602242] Eur J Haematol Suppl. 1996;60:111-8 [8987252] Environ Health Perspect. 1996 Dec;104 Suppl 6:1247-50 [9118900] Mutat Res. 1997 Jan 3;373(1):113-23 [9015160] Endocr Rev. 1997 Feb;18(1):4-25 [9034784] Blood. 1997 Mar 15;89(6):1870-5 [9058706] Cancer Res. 1997 Jul 15;57(14):2839-42 [9230185] J Natl Cancer Inst. 1997 Jul 16;89(14):1065-71 [9230889] Blood. 1997 Oct 15;90(8):3167-72 [9376599] Toxicol Ind Health. 1997 Nov-Dec;13(6):661-714 [9399416] Cancer Res. 1998 May 15;58(10):2176-81 [9605763] J Biol Chem. 1998 Nov 13;273(46):30336-43 [9804796] Carcinogenesis. 1998 Nov;19(11):1955-61 [9855009] Science. 2004 Dec 3;306(5702):1774-6 [15576619] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Aug;23(4):248-51 [16188086] Cancer Res. 2005 Oct 15;65(20):9574-81 [16230423] Hum Genet. 2006 Jul;119(6):659-68 [16738949] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Jul;24(7):390-3 [16889696] Carcinogenesis. 2006 Oct;27(10):2083-9 [16728435] J Exp Med. 1990 Dec 1;172(6):1535-45 [2258694] J Natl Cancer Inst. 2004 Mar 17;96(6):434-42 [15026468] Ann Occup Hyg. 2004 Mar;48(2):105-16 [14990432] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Nat Med. 2003 Jun;9(6):669-76 [12778165] J Mol Med (Berl). 2003 Jan;81(1):20-31 [12545246] Br J Haematol. 2002 Jul;118(1):151-6 [12100142] J Toxicol Environ Health A. 2000 Nov;61(5-6):357-72 [11086940] Blood. 2001 Mar 1;97(5):1427-34 [11222390] Carcinogenesis. 2009 Jan;30(1):50-8 [18978339] Cytokine. 2008 Aug;43(2):215-9 [18621544] Am J Physiol Cell Physiol. 2008 Mar;294(3):C675-82 [18234850] Genet Epidemiol. 2007 Dec;31(8):803-12 [17549762] J Mol Cell Cardiol. 2007 Jan;42(1):142-9 [17070836] J Environ Monit. 2006 Nov;8(11):1143-8 [17075621] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):687-96 [11401920] Am J Ind Med. 2001 Aug;40(2):117-26 [11494338] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Nature. 2002 Jun 27;417(6892):954-8 [12087404] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/oem.2008.044024 ER - TY - JOUR T1 - NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation. AN - 734153734; 19786557 AB - Cells respond to oxidants and electrophiles by activating receptor/transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) to coordinate the induction of cytoprotective genes critical for defense against oxidative and other stresses. Activation involves blocking the ubiquitination-proteasomal degradation of Nrf2. Modification of cysteine thiol groups by inducers in the linker region of Kelch-like ECH-associated protein-1 (Keap1), which congregates Nrf2 into the Keap1/Cul3 E3 complex for ubiquitination, is important but not sufficient for activation of Nrf2. Here we show that evolutionarily conserved cysteine residues of Nrf2 are critical for Nrf2 regulation. FlAsH (an arsenic-based fluorophore) and phenylarsine oxide (PAO) potently induce Nrf2 target genes and bind to Nrf2 in vitro and in vivo. Binding is inhibited by prototypical inducers arsenic and tert-butylhydroquinone. PAO affinity pull-down and mutation of individual cysteine to alanine reveal that Cys235, Cys311, Cys316, Cys414, and Cys506 are critical for binding, and binding is modulated by intramolecular interactions. To corroborate the functions of cysteine residues, Nrf2 wild-type or mutants are expressed in Nrf2 knockout cells to reconstitute Nrf2 regulation. Nrf2 mutants have reduced t(1/2) that inversely correlates with increased binding to Keap1 and polyubiquitination of mutant proteins. It is remarkable that the mutants fail to respond to arsenic for Nrf2 activation and gene induction. Furthermore, mutations at Cys119, Cys235, and Cys506 impede binding of Nrf2 to endogenous antioxidant response element and to coactivator cAMP response element-binding protein-binding protein/p300. The findings demonstrate that Nrf2 cysteine residues critically regulate oxidant/electrophile sensing, repress Keap1-dependent ubiquitination-proteasomal degradation, and promote recruitment of coactivators, such that chemical sensing, receptor activation, and transcription activation are integrated at the receptor molecule. JF - Molecular pharmacology AU - He, Xiaoqing AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention Morgantown, Morgantown, WV 26505, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1265 EP - 1278 VL - 76 IS - 6 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Arsenicals KW - Cul3 protein, mouse KW - Cullin Proteins KW - Cytoskeletal Proteins KW - Enzyme Inhibitors KW - Keap1 protein, mouse KW - Kelch-Like ECH-Associated Protein 1 KW - NF-E2-Related Factor 2 KW - Nfe2l2 protein, mouse KW - oxophenylarsine KW - 0HUR2WY345 KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Blotting, Northern KW - Arsenicals -- pharmacology KW - Mice KW - Protein Binding KW - Mutagenesis, Site-Directed KW - Oxidative Stress -- physiology KW - Proteasome Endopeptidase Complex -- metabolism KW - Conserved Sequence KW - Ubiquitination -- drug effects KW - Enzyme Inhibitors -- pharmacology KW - Cullin Proteins -- drug effects KW - Cell Line KW - Cytoskeletal Proteins -- biosynthesis KW - Cytoskeletal Proteins -- drug effects KW - Adaptor Proteins, Signal Transducing -- physiology KW - Cytoskeletal Proteins -- physiology KW - NF-E2-Related Factor 2 -- physiology KW - NF-E2-Related Factor 2 -- genetics KW - Transcriptional Activation -- physiology KW - Transcriptional Activation -- drug effects KW - Adaptor Proteins, Signal Transducing -- biosynthesis KW - Adaptor Proteins, Signal Transducing -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734153734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=NRF2+cysteine+residues+are+critical+for+oxidant%2Felectrophile-sensing%2C+Kelch-like+ECH-associated+protein-1-dependent+ubiquitination-proteasomal+degradation%2C+and+transcription+activation.&rft.au=He%2C+Xiaoqing%3BMa%2C+Qiang&rft.aulast=He&rft.aufirst=Xiaoqing&rft.date=2009-12-01&rft.volume=76&rft.issue=6&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=1521-0111&rft_id=info:doi/10.1124%2Fmol.109.058453 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-17 N1 - Date created - 2009-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5 [11248092] J Pharmacol Exp Ther. 2010 Jan;332(1):66-75 [19808700] Biochem J. 2001 Jun 1;356(Pt 2):621-6 [11368793] Am J Respir Cell Mol Biol. 2002 Jan;26(1):42-51 [11751202] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13 [12193649] Annu Rev Pharmacol Toxicol. 2003;43:233-60 [12359864] Nat Genet. 2003 Nov;35(3):238-45 [14517554] J Biol Chem. 2003 Nov 28;278(48):48021-9 [12968018] Methods Enzymol. 2004;378:273-86 [15038975] Biochem J. 2004 Jun 15;380(Pt 3):695-703 [14998373] Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4584-9 [15767573] Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10070-5 [16006525] J Biol Chem. 2005 Sep 9;280(36):31768-75 [15985429] Mol Cell Biol. 2006 Jan;26(1):221-9 [16354693] Mol Cell Biol. 2006 Feb;26(3):940-54 [16428448] Am J Pathol. 2006 Jun;168(6):1960-74 [16723711] Cancer Lett. 2006 Aug 28;240(2):243-52 [16271437] J Biol Chem. 2006 Aug 18;281(33):23620-31 [16785233] J Biol Chem. 2006 Sep 15;281(37):27251-63 [16790425] Annu Rev Pharmacol Toxicol. 2007;47:89-116 [16968214] Cell Biol Int. 2007 Jan;31(1):57-64 [17049468] Am J Pathol. 2007 Jun;170(6):2068-76 [17525273] Toxicol Sci. 2007 Jul;98(1):298-309 [17420218] FASEB J. 2007 Jul;21(9):2237-46 [17384144] Cancer Res. 2008 Mar 1;68(5):1303-9 [18316592] Mol Cell Biol. 2008 Apr;28(8):2758-70 [18268004] Curr Drug Metab. 2008 Jun;9(5):374-83 [18537574] Chem Res Toxicol. 2008 Jul;21(7):1375-83 [18512965] Chem Res Toxicol. 2008 Sep;21(9):1651-71 [18707139] J Mol Cell Cardiol. 2009 Jan;46(1):47-58 [19007787] Mol Cell Biol. 2009 Jan;29(2):493-502 [19001094] Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5 [19104057] J Biol Chem. 2009 May 8;284(19):12609-21 [19276070] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4611-6 [11287661] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/mol.109.058453 ER - TY - JOUR T1 - Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. AN - 734142608; 19805409 AB - In support of the U.S. Tox21 program, we have developed a simple and chemically intuitive model we call weighted feature significance (WFS) to predict the toxicological activity of compounds, based on the statistical enrichment of structural features in toxic compounds. We trained and tested the model on the following: (1) data from quantitative high-throughput screening cytotoxicity and caspase activation assays conducted at the National Institutes of Health Chemical Genomics Center, (2) data from Salmonella typhimurium reverse mutagenicity assays conducted by the U.S. National Toxicology Program, and (3) hepatotoxicity data published in the Registry of Toxic Effects of Chemical Substances. Enrichments of structural features in toxic compounds are evaluated for their statistical significance and compiled into a simple additive model of toxicity and then used to score new compounds for potential toxicity. The predictive power of the model for cytotoxicity was validated using an independent set of compounds from the U.S. Environmental Protection Agency tested also at the National Institutes of Health Chemical Genomics Center. We compared the performance of our WFS approach with classical classification methods such as Naive Bayesian clustering and support vector machines. In most test cases, WFS showed similar or slightly better predictive power, especially in the prediction of hepatotoxic compounds, where WFS appeared to have the best performance among the three methods. The new algorithm has the important advantages of simplicity, power, interpretability, and ease of implementation. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Huang, Ruili AU - Southall, Noel AU - Xia, Menghang AU - Cho, Ming-Hsuang AU - Jadhav, Ajit AU - Nguyen, Dac-Trung AU - Inglese, James AU - Tice, Raymond R AU - Austin, Christopher P AD - Department of Health and Human Services, NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892-3370, USA. huangru@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 385 EP - 393 VL - 112 IS - 2 KW - Index Medicus KW - Mutagenicity Tests KW - Humans KW - Salmonella typhimurium -- genetics KW - Cell Line KW - Structure-Activity Relationship KW - Toxicity Tests KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734142608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Weighted+feature+significance%3A+a+simple%2C+interpretable+model+of+compound+toxicity+based+on+the+statistical+enrichment+of+structural+features.&rft.au=Huang%2C+Ruili%3BSouthall%2C+Noel%3BXia%2C+Menghang%3BCho%2C+Ming-Hsuang%3BJadhav%2C+Ajit%3BNguyen%2C+Dac-Trung%3BInglese%2C+James%3BTice%2C+Raymond+R%3BAustin%2C+Christopher+P&rft.aulast=Huang&rft.aufirst=Ruili&rft.date=2009-12-01&rft.volume=112&rft.issue=2&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfp231 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-25 N1 - Date created - 2009-11-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chem Inf Comput Sci. 2000 Jul-Aug;40(4):906-14 [10955517] Environ Health Perspect. 2008 Mar;116(3):284-91 [18335092] J Med Chem. 2002 Sep 12;45(19):4350-8 [12213076] Nat Rev Drug Discov. 2003 Jul;2(7):542-53 [12815380] J Chem Inf Comput Sci. 2003 Jul-Aug;43(4):1192-9 [12870911] Chem Res Toxicol. 2004 Jan;17(1):3-16 [14727914] J Chem Inf Comput Sci. 2004 Mar-Apr;44(2):704-15 [15032553] Nat Rev Drug Discov. 2004 Aug;3(8):711-5 [15286737] J Chem Inf Comput Sci. 1978 Aug;18(3):134-40 [681458] Mutat Res. 1991 May;257(3):229-306 [1707500] Hum Exp Toxicol. 1991 Jul;10(4):261-73 [1679649] Mutat Res. 1994 Feb 1;305(1):47-61 [7508547] Toxicol Lett. 1995 Sep;79(1-3):219-28 [7570659] Arch Biochem Biophys. 2005 Jan 15;433(2):369-78 [15581593] Curr Drug Metab. 2005 Jun;6(3):161-225 [15975040] Environ Health Perspect. 2005 Nov;113(11):1569-74 [16263513] Bioorg Med Chem. 2006 Apr 15;14(8):2779-88 [16377200] J Chem Inf Model. 2006 Mar-Apr;46(2):536-44 [16562981] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Chem Res Toxicol. 2006 Nov;19(11):1533-9 [17112242] Anal Biochem. 2007 Mar 15;362(2):221-8 [17266913] Chem Res Toxicol. 2007 Mar;20(3):344-69 [17302443] Mini Rev Med Chem. 2007 May;7(5):499-507 [17504185] Science. 2008 Feb 15;319(5865):906-7 [18276874] Chem Res Toxicol. 2008 Mar;21(3):659-67 [18281954] Environ Toxicol. 2001;16(6):543-9 [11769253] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfp231 ER - TY - JOUR T1 - Chlordecone increased subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes without altering cytosolic cholesterol binding proteins. AN - 734132026; 19666090 AB - Pretreatment of male C57BL/6 mice with low doses of the persistent organochlorine pesticide, chlordecone (CD), stimulated biliary excretion of exogenous cholesterol (CH) up to 3-fold. Increased biliary excretion occurred without changes in hepatic ATP-binding cassette transporter G8 (ABCG8) of the bile canaliculus or scavenger receptor class B type I (SR-BI) of the sinusoidal surface. A variety of tissues express scavenger receptor class B type II (SR-BII) and this protein was identified as a splice variant from the SR-BI gene. Although the function of SR-BII has not been elucidated it may play a role in CH homeostasis and trafficking distinctly different than SR-BI. Western blotting demonstrated that a single dose of CD promoted subcellular distribution of SR-BII to murine hepatic microsomes about 2.2-fold when compared to controls without effect on liver crude membrane SR-BII content. This was consistent with increased vesicular CH trafficking. Relative quantification of hepatic cytosolic proteins in a fraction that sequestered [(14)C]CH by mass spectrometry (MS) indicated no role for cytosolic CH binding proteins in CD altered CH homeostasis. Western blotting verified no effect of CD on liver fatty acid-binding protein (L-FABP) in cytosol. MS detected a statistically significant increase in myosin-9, which was also consistent with increased vesicular trafficking. JF - Toxicology letters AU - Scheri, Richard C AU - Lee, Junga AU - Barofsky, Douglas F AU - Curtis, Lawrence R AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2009/12/01/ PY - 2009 DA - 2009 Dec 01 SP - 20 EP - 25 VL - 191 IS - 1 KW - Carrier Proteins KW - 0 KW - Fatty Acid-Binding Proteins KW - Insecticides KW - Scavenger Receptors, Class B KW - Pancreatic Elastase KW - EC 3.4.21.36 KW - cholesterol-binding protein KW - Chlordecone KW - RG5XJ88UDF KW - Index Medicus KW - Mass Spectrometry KW - Animals KW - Blotting, Western KW - Electrophoresis, Polyacrylamide Gel KW - Mice, Inbred C57BL KW - Mice KW - Bile -- metabolism KW - Homeostasis -- drug effects KW - Male KW - Fatty Acid-Binding Proteins -- metabolism KW - Subcellular Fractions -- drug effects KW - Insecticides -- toxicity KW - Cytosol -- metabolism KW - Carrier Proteins -- metabolism KW - Cytosol -- drug effects KW - Microsomes, Liver -- metabolism KW - Microsomes, Liver -- drug effects KW - Subcellular Fractions -- metabolism KW - Scavenger Receptors, Class B -- metabolism KW - Chlordecone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734132026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Chlordecone+increased+subcellular+distribution+of+scavenger+receptor+class+B+type+II+to+murine+hepatic+microsomes+without+altering+cytosolic+cholesterol+binding+proteins.&rft.au=Scheri%2C+Richard+C%3BLee%2C+Junga%3BBarofsky%2C+Douglas+F%3BCurtis%2C+Lawrence+R&rft.aulast=Scheri&rft.aufirst=Richard&rft.date=2009-12-01&rft.volume=191&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2009.07.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-30 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2006 Feb 17;281(7):4348-53 [16368683] J Lipid Res. 2006 Feb;47(2):421-30 [16264196] Mol Cell Endocrinol. 2006 Mar 9;247(1-2):22-33 [16297529] Hepatology. 2006 Nov;44(5):1259-66 [17058264] Mol Biol Cell. 2007 Apr;18(4):1507-18 [17314409] Prog Lipid Res. 2007 Nov;46(6):297-314 [17709145] Nat Rev Mol Cell Biol. 2008 Feb;9(2):125-38 [18216769] Toxicol Appl Pharmacol. 2008 Jun 15;229(3):265-72 [18387646] J Lipid Res. 2008 Jul;49(7):1569-76 [18375996] Rapid Commun Mass Spectrom. 2008 Oct;22(20):3137-46 [18798194] Toxicol Appl Pharmacol. 2008 Dec 1;233(2):193-202 [18789348] J Biol Chem. 2000 Feb 25;275(8):5958-65 [10681589] J Biol Chem. 2000 May 12;275(19):14457-65 [10799528] J Clin Invest. 2002 Sep;110(5):583-90 [12208856] Biochem Pharmacol. 2002 Nov 15;64(10):1513-9 [12417264] Genes Dev. 2003 May 1;17(9):1115-29 [12695333] Endocr Rev. 2003 Jun;24(3):357-87 [12788804] Int J Biochem Cell Biol. 2004 Jan;36(1):39-77 [14592533] Biochem J. 2004 Feb 1;377(Pt 3):741-7 [14570588] J Lipid Res. 2004 Mar;45(3):427-37 [14679167] J Biol Chem. 2004 Apr 2;279(14):14372-81 [14726519] Metabolism. 1978 Jan;27(1):89-96 [201821] Am J Epidemiol. 1978 Jun;107(6):529-37 [78669] J Toxicol Environ Health. 1978 Sep-Nov;4(5-6):895-911 [83367] Annu Rev Pharmacol Toxicol. 1982;22:517-54 [6282188] Annu Rev Pharmacol Toxicol. 1982;22:89-113 [6177278] Neurotoxicology. 1982 Oct;3(2):103-10 [6186954] Drug Metab Dispos. 1989 Mar-Apr;17(2):131-8 [2468465] Drug Metab Dispos. 1991 May-Jun;19(3):673-8 [1717217] J Clin Invest. 1997 Feb 1;99(3):380-4 [9022069] J Biol Chem. 1998 Jun 12;273(24):15241-8 [9614139] Neurotoxicology. 1998 Aug-Oct;19(4-5):581-90 [9745915] J Biol Chem. 2005 Mar 11;280(10):8742-7 [15611112] Biochim Biophys Acta. 2005 May 1;1734(1):44-51 [15866482] Environ Sci Technol. 2005 Sep 15;39(18):6952-60 [16201616] Oncogene. 2005 Dec 1;24(54):8038-50 [16170382] Lancet. 2006 Feb 11;367(9509):454-6 [16473109] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2009.07.029 ER - TY - JOUR T1 - Effect of dehydrated storage on the survival of Francisella tularensis in infant formula. AN - 734092598; 19835784 AB - Francisella tularensis is a Gram-negative bacterium that can cause gastrointestinal or oropharyngeal tularemia in humans from ingestion of contaminated food or water. Despite the potential for accidental or intentional contamination of foods with F. tularensis, there are few studies on the long-term survivability of this organism in food matrices. Infant formula has previously been implicated as a vehicle for the transmission of a variety of bacterial pathogens in infants. In this study, we investigated the survival of F. tularensis in dehydrated infant formula under various storage conditions. F. tularensis was stored for up to 12 weeks in dehydrated infant formula in an ambient air, dry or nitrogen atmosphere. Viable counts of fresh F. tularensis at 12 weeks in infant formula revealed a 4.15, 3.37 and 3.72-log decrease in ambient air, dry and nitrogen atmosphere, respectively. D-values were calculated (in weeks) as 3.99, 4.68 and 4.47 in air, dry and nitrogen atmosphere, respectively. JF - Food microbiology AU - Day, J B AU - Nguyen, H AU - Sharma, S K AU - Al-Khaldi, S F AU - Hao, Y-Y D AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. james.day@fda.hhs.gov Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 932 EP - 935 VL - 26 IS - 8 KW - Nitrogen KW - N762921K75 KW - Index Medicus KW - Infant KW - Food Microbiology KW - Consumer Product Safety KW - Tularemia -- prevention & control KW - Tularemia -- epidemiology KW - Humans KW - Infant, Newborn KW - Colony Count, Microbial KW - Nitrogen -- pharmacology KW - Air KW - Time Factors KW - Dehydration KW - Food Contamination -- prevention & control KW - Infant Formula KW - Food Packaging -- methods KW - Food Contamination -- analysis KW - Food Preservation -- methods KW - Francisella tularensis -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734092598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+microbiology&rft.atitle=Effect+of+dehydrated+storage+on+the+survival+of+Francisella+tularensis+in+infant+formula.&rft.au=Day%2C+J+B%3BNguyen%2C+H%3BSharma%2C+S+K%3BAl-Khaldi%2C+S+F%3BHao%2C+Y-Y+D&rft.aulast=Day&rft.aufirst=J&rft.date=2009-12-01&rft.volume=26&rft.issue=8&rft.spage=932&rft.isbn=&rft.btitle=&rft.title=Food+microbiology&rft.issn=1095-9998&rft_id=info:doi/10.1016%2Fj.fm.2009.06.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-04 N1 - Date created - 2009-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fm.2009.06.005 ER - TY - JOUR T1 - Cadmium malignantly transforms normal human breast epithelial cells into a basal-like phenotype. AN - 733687761; 20049202 AB - Breast cancer has recently been linked to cadmium exposure. Although not uniformly supported, it is hypothesized that cadmium acts as a metalloestrogenic carcinogen via the estrogen receptor (ER). Thus, we studied the effects of chronic exposure to cadmium on the normal human breast epithelial cell line MCF-10A, which is ER-negative but can convert to ER-positive during malignant transformation. Cells were continuously exposed to low-level cadmium (2.5 muM) and checked in vitro and by xenograft study for signs of malignant transformation. Transformant cells were molecularly characterized by protein and transcript analysis of key genes in breast cancer. Over 40 weeks of cadmium exposure, cells showed increasing secretion of matrix metalloproteinase-9, loss of contact inhibition, increased colony formation, and increasing invasion, all typical for cancer cells. Inoculation of cadmium-treated cells into mice produced invasive, metastatic anaplastic carcinoma with myoepithelial components. These cadmium-transformed breast epithelial (CTBE) cells displayed characteristics of basal-like breast carcinoma, including ER-alpha negativity and HER2 (human epidermal growth factor receptor 2) negativity, reduced expression of BRCA1 (breast cancer susceptibility gene 1), and increased CK5 (cytokeratin 5) and p63 expression. CK5 and p63, both breast stem cell markers, were prominently overexpressed in CTBE cell mounds, indicative of persistent proliferation. CTBE cells showed global DNA hypomethylation and c-myc and k-ras overexpression, typical in aggressive breast cancers. CTBE cell xenograft tumors were also ER-alpha negative. Cadmium malignantly transforms normal human breast epithelial cells-through a mechanism not requiring ER-alpha-into a basal-like cancer phenotype. Direct cadmium induction of a malignant phenotype in human breast epithelial cells strongly fortifies a potential role in breast cancer. JF - Environmental health perspectives AU - Benbrahim-Tallaa, Lamia AU - Tokar, Erik J AU - Diwan, Bhalchandra A AU - Dill, Anna L AU - Coppin, Jean-François AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute (NCI) at National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1847 EP - 1852 VL - 117 IS - 12 KW - CKAP4 protein, human KW - 0 KW - Estrogen Receptor alpha KW - Keratin-5 KW - Membrane Proteins KW - Cadmium KW - 00BH33GNGH KW - Aromatase KW - EC 1.14.14.1 KW - Index Medicus KW - malignant transformation KW - breast cancer KW - basal-type KW - cadmium KW - estrogen receptor KW - Phenotype KW - Animals KW - Aromatase -- metabolism KW - Humans KW - Estrogen Receptor alpha -- analysis KW - Mice KW - Cell Line, Tumor KW - Membrane Proteins -- analysis KW - Keratin-5 -- analysis KW - Female KW - Cadmium -- toxicity KW - Breast Neoplasms -- chemically induced KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733687761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cadmium+malignantly+transforms+normal+human+breast+epithelial+cells+into+a+basal-like+phenotype.&rft.au=Benbrahim-Tallaa%2C+Lamia%3BTokar%2C+Erik+J%3BDiwan%2C+Bhalchandra+A%3BDill%2C+Anna+L%3BCoppin%2C+Jean-Fran%C3%A7ois%3BWaalkes%2C+Michael+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=Lamia&rft.date=2009-12-01&rft.volume=117&rft.issue=12&rft.spage=1847&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0900999 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-10 N1 - Date created - 2010-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2000 Apr;14(4):545-53 [10770491] Mod Pathol. 2007 Jul;20(7):711-21 [17464311] Biol Reprod. 2000 Jul;63(1):259-66 [10859267] J Mammary Gland Biol Neoplasia. 2002 Jan;7(1):3-15 [12160084] Exp Cell Res. 2003 Jun 10;286(2):355-65 [12749863] Nat Med. 2003 Aug;9(8):1081-4 [12858169] Cell Prolif. 2003 Oct;36 Suppl 1:73-84 [14521517] Mutat Res. 2003 Dec 10;533(1-2):107-20 [14643415] Mutat Res. 2003 Dec 10;533(1-2):201-9 [14643421] Breast Cancer Res Treat. 2004 Apr;84(3):273-88 [15026625] Adv Anat Pathol. 2007 Sep;14(5):358-73 [17717437] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1680-5 [18230721] Appl Immunohistochem Mol Morphol. 2008 Mar;16(2):108-12 [18227734] Medicina (Kaunas). 2008;44(6):415-20 [18660635] Cancer Res. 2008 Aug 1;68(15):6435-41 [18676869] J Mammary Gland Biol Neoplasia. 2004 Jan;9(1):27-37 [15082916] Pathol Oncol Res. 2004;10(2):74-9 [15188022] Cancer Res. 2004 Jul 1;64(13):4585-92 [15231670] Oncogene. 2004 Jul 29;23(34):5792-8 [15122325] Cancer Res. 2004 Oct 1;64(19):7078-85 [15466203] Cancer Res. 1990 Sep 15;50(18):6075-86 [1975513] J Biol Chem. 1994 Jun 17;269(24):16896-901 [8207012] IARC Monogr Eval Carcinog Risks Hum. 1993;58:119-237 [8022055] Sci Total Environ. 1996 Jul 30;186(3):251-6 [8677430] Int J Oncol. 1998 Nov;13(5):907-15 [9772278] Breast Cancer Res. 2004;6(6):229-39 [15535852] Int J Cancer. 2005 Apr 10;114(3):346-55 [15551354] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Przegl Lek. 2004;61(7):786-8 [15792022] Anticancer Res. 2005 Jan-Feb;25(1A):369-75 [15816560] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Clin Exp Metastasis. 2005;22(3):275-84 [16158255] Histopathology. 2005 Nov;47(5):458-66 [16241993] Cancer Res. 2006 Feb 15;66(4):1883-90; discussion 1895-6 [16488983] Nature. 2006 Feb 23;439(7079):993-7 [16395311] J Appl Toxicol. 2006 May-Jun;26(3):191-7 [16489580] J Natl Cancer Inst. 2006 Jun 21;98(12):869-73 [16788160] Toxicol Appl Pharmacol. 2006 Oct 1;216(1):20-8 [16716372] Trends Mol Med. 2006 Nov;12(11):537-44 [17011236] Stem Cell Rev. 2005;1(3):207-13 [17142857] J Biol Chem. 2007 Feb 16;282(7):4243-52 [17130135] Neuro Endocrinol Lett. 2006 Dec;27 Suppl 1:36-9 [16804515] Comment In: Environ Health Perspect. 2009 Dec;117(12):A552 [20049192] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0900999 ER - TY - JOUR T1 - Elastic and shear moduli of coal measure rocks derived from basic well logs using fractal statistics and radial basis functions AN - 50097472; 2010-014152 AB - Gamma ray, density, sonic and core logs obtained from two boreholes drilled over a longwall panel in Southwestern (SW) Pennsylvania were analyzed for formation boundaries, log-derived porosities and densities and for rock elastic properties from sonic transit times. Gamma ray (GR) and density logs (DL) were analyzed using univariate statistical techniques and fractal statistics for similarity and ordering of the log data in depth. A Fourier transformation with low-pass filter was used as a noise elimination (filtering) technique from the original logs. Filtered data was tested using basic univariate and fractal statistics, rescaled range (R/S) and power spectrum (PS) analysis to compare the information characteristics of the filtered logs with the original data. The randomness of log data in depth was analyzed for fractional Gaussian noise (fGn) or fractional Brownian motion (fBm) character. A new prediction technique using radial basis function (RBF) networks was developed to calculate shear and Young's moduli of the formations when sonic logs are not available. For this approach, the filtered logs were used as input to an RBF based upon a combination of supervised and unsupervised learning. The network was trained and tested using rock elastic properties calculated from the sonic log of one of the boreholes. The network was used to predict the elastic and shear moduli of the coal-measure rocks over a longwall coal mine in SW Pennsylvania. This approach demonstrated that it could be used for prediction of elastic and shear moduli of coal-measure rocks with reasonable accuracy. JF - International Journal of Rock Mechanics and Mining Sciences (1997) AU - Ozgen Karacan, C Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1281 EP - 1295 PB - Elsevier, Oxford-New York VL - 46 IS - 8 SN - 1365-1609, 1365-1609 KW - United States KW - mining KW - underground mining KW - elastic properties KW - well-logging KW - elastic constants KW - coal seams KW - density logging KW - rock mechanics KW - sedimentary rocks KW - coal KW - fractals KW - monitoring KW - gamma-ray methods KW - well logs KW - shale KW - prediction KW - mathematical models KW - longwall mining KW - southwestern Pennsylvania KW - shear KW - shear modulus KW - Pennsylvania KW - clastic rocks KW - Young's modulus KW - 30:Engineering geology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50097472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.atitle=Elastic+and+shear+moduli+of+coal+measure+rocks+derived+from+basic+well+logs+using+fractal+statistics+and+radial+basis+functions&rft.au=Ozgen+Karacan%2C+C&rft.aulast=Ozgen+Karacan&rft.aufirst=C&rft.date=2009-12-01&rft.volume=46&rft.issue=8&rft.spage=1281&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.issn=13651609&rft_id=info:doi/10.1016%2Fj.ijrmms.2009.04.002 L2 - http://www.sciencedirect.com/science/journal/13651609 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - Number of references - 28 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - IJRMA2 N1 - SubjectsTermNotLitGenreText - clastic rocks; coal; coal seams; density logging; elastic constants; elastic properties; fractals; gamma-ray methods; longwall mining; mathematical models; mining; monitoring; Pennsylvania; prediction; rock mechanics; sedimentary rocks; shale; shear; shear modulus; southwestern Pennsylvania; underground mining; United States; well logs; well-logging; Young's modulus DO - http://dx.doi.org/10.1016/j.ijrmms.2009.04.002 ER - TY - JOUR T1 - Development of a Test System To Evaluate Procedures for Decontamination of Respirators Containing Viral Droplets AN - 21508773; 12510473 AB - The aim of this study was to develop a test system to evaluate the effectiveness of procedures for decontamination of respirators contaminated with viral droplets. MS2 coliphage was used as a surrogate for pathogenic viruses. A viral droplet test system was constructed, and the size distribution of viral droplets loaded directly onto respirators was characterized using an aerodynamic particle sizer. The sizes ranged from 0.5 to 15 km, and the sizes of the majority of the droplets were the range from 0.74 to 3.5 km. The results also showed that the droplet test system generated similar droplet concentrations (particle counts) at different respirator locations. The test system was validated by studying the relative efficiencies of decontamination of sodium hypochlorite (bleach) and UV irradiation with droplets containing MS2 virus on filtering facepiece respirators. It was hypothesized that more potent decontamination treatments would result in corresponding larger decreases in the number of viable viruses recovered from the respirators. Sodium hypochlorite doses of 2.75 to 5.50 mg/liter with a 10-min decontamination period resulted in approximately 3- to 4-log reductions in the level of MS2 coliphage. When higher sodium hypochlorite doses (8.25 mg/liter) were used with the same contact time that was used for the dilute solutions containing 2.75 to 5.50 mg/liter, all MS2 was inactivated. For UV decontamination at a wavelength of 254 nm, an approximately 3-log reduction in the level of MS2 virus was achieved with dose of 4.32 J/cm2 (3 h of contact time with a UV intensity of 0.4 mW/cm2), while with higher doses of UV irradiation (7.20 J/cm2; UV intensity, 0.4 mW/cm2; contact times, 5 h), all MS2 was inactivated. These findings may lead to development of a standard method to test decontamination of respirators challenged by viral droplets. JF - Applied and Environmental Microbiology AU - Vo, Evanly AU - Rengasamy, Samy AU - Shaffer, Ronald AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, 626 Cochrans Mill Road, Pittsburgh, Pennsylvania 15236, RShaffer@cdc.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 7303 EP - 7309 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 75 IS - 23 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Bleaches KW - Decontamination KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21508773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Development+of+a+Test+System+To+Evaluate+Procedures+for+Decontamination+of+Respirators+Containing+Viral+Droplets&rft.au=Vo%2C+Evanly%3BRengasamy%2C+Samy%3BShaffer%2C+Ronald&rft.aulast=Vo&rft.aufirst=Evanly&rft.date=2009-12-01&rft.volume=75&rft.issue=23&rft.spage=7303&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00799-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Decontamination DO - http://dx.doi.org/10.1128/AEM.00799-09 ER - TY - JOUR T1 - Bladder cancer and reproductive factors among women in Spain AN - 21323980; 11906509 AB - Hormonal factors, possibly related to reproductive characteristics, may play a role in the risk of bladder cancer among women. To study this, we investigated the effects of reproductive factors on female bladder cancer risk. Information on reproductive and other risk factors was gathered in personal interviews from 152 female cases and 166 matched controls from 18 hospitals in five regions of Spain during 1998-2001. Logistic regression was used to estimate the association between bladder cancer and reproductive factors, including ever-parous status, age at first live birth, age at last live birth, age at menarche, age at menopause, menopausal status, and duration of menstruation. After adjustment for age, smoking, and high-risk occupation, ever-parous women were at decreased risk relative to nulliparous women (odds ratio=0.43, 95% confidence interval=0.21-0.87). There was no consistent pattern in risk with the age- or duration-related reproductive factors (e.g., age at first live birth, age at last live birth, age at menarche, age at menopause, menopausal status, and duration of menstruation) that we evaluated. Women have a lower risk of bladder cancer than men, and hormonal factors related to childbearing may play a role. JF - Cancer Causes & Control AU - Huang, An-Tsun AU - Kogevinas, Manolis AU - Silverman, Debra T AU - Malats, Na'ria AU - Rothman, Nathaniel AU - Tardon, Adonina AU - Serra, Consol AU - Garcia-Closas, Reina AU - Carrato, Alfredo AU - Cantor, Kenneth P AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, huangan@mail.nih.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1907 EP - 1913 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 20 IS - 10 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - urinary bladder KW - Smoking KW - Age KW - Spain KW - menopause KW - Females KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21323980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Bladder+cancer+and+reproductive+factors+among+women+in+Spain&rft.au=Huang%2C+An-Tsun%3BKogevinas%2C+Manolis%3BSilverman%2C+Debra+T%3BMalats%2C+Na%27ria%3BRothman%2C+Nathaniel%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BGarcia-Closas%2C+Reina%3BCarrato%2C+Alfredo%3BCantor%2C+Kenneth+P&rft.aulast=Huang&rft.aufirst=An-Tsun&rft.date=2009-12-01&rft.volume=20&rft.issue=10&rft.spage=1907&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-009-9384-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Smoking; urinary bladder; Age; menopause; Females; Cancer; Spain DO - http://dx.doi.org/10.1007/s10552-009-9384-1 ER - TY - JOUR T1 - Decolorization of water and oil-soluble azo dyes by Lactobacillus acidophilus and Lactobacillus fermentum AN - 21290089; 11905891 AB - The capability of Lactobacillus acidophilus and Lactobacillus fermentum to degrade azo dyes was investigated. The bacteria were incubated under anaerobic conditions in the presence of 6kg/ml Methyl Red, Ponceau BS, Orange G, Amaranth, Orange II, and Direct Blue 15; 5kg/ml Sudan I and II; or 1.5kg/ml Sudan III and IV in deMann-Rogosa-Sharpe broth at 37C for 36h, and reduction of the dyes was monitored. Both bacteria were capable of degrading all of the water-soluble azo dyes to some extent. They were also able to completely reduce the oil-soluble diazo dyes Sudan III and IV but were unable to reduce the oil-soluble monoazo dyes Sudan I and II to any significant degree in the concentrations studied. Growth of the bacteria was not significantly affected by the presence of the Sudan azo dyes. Metabolites of the bacterial degradation of Sudan III and IV were isolated and identified by liquid chromatography electrospray ionization tandem mass spectrometry analyses and compared with authentic standards. Aniline and o-toluidine (2-methylaniline), both potentially carcinogenic aromatic amines, were metabolites of Sudan III and IV, respectively. JF - Journal of Industrial Microbiology & Biotechnology AU - Chen, Huizhong AU - Xu, Haiyan AU - Heinze, Thomas M AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR, 72079-9502, USA, huizhong.chen@fda.hhs.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1459 EP - 1466 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 36 IS - 12 SN - 1367-5435, 1367-5435 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Azo dyes KW - Lactobacillus acidophilus KW - o-toluidine KW - Metabolites KW - Anaerobic conditions KW - Mass spectroscopy KW - Lactobacillus fermentum KW - amaranth KW - amines KW - Dyes KW - Liquid chromatography KW - Aromatics KW - decolorization KW - Aniline KW - J 02320:Cell Biology KW - A 01320:Microbial Degradation KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21290089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.atitle=Decolorization+of+water+and+oil-soluble+azo+dyes+by+Lactobacillus+acidophilus+and+Lactobacillus+fermentum&rft.au=Chen%2C+Huizhong%3BXu%2C+Haiyan%3BHeinze%2C+Thomas+M%3BCerniglia%2C+Carl+E&rft.aulast=Chen&rft.aufirst=Huizhong&rft.date=2009-12-01&rft.volume=36&rft.issue=12&rft.spage=1459&rft.isbn=&rft.btitle=&rft.title=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.issn=13675435&rft_id=info:doi/10.1007%2Fs10295-009-0633-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - amines; amaranth; Dyes; Liquid chromatography; Azo dyes; o-toluidine; Metabolites; Anaerobic conditions; Mass spectroscopy; Aromatics; Aniline; decolorization; Lactobacillus fermentum; Lactobacillus acidophilus DO - http://dx.doi.org/10.1007/s10295-009-0633-9 ER - TY - JOUR T1 - Fall from equipment injuries in U.S. mining: Identification of specific research areas for future investigation AN - 21283637; 12520538 AB - Introduction - The objective of this study was to evaluate the circumstances leading to fall from equipment injuries in the mining industry. Method - The 2006 and 2007 Mine Safety and Health Administration annual injury databases were utilized for this study whereby the injury narrative, nature of injury, body part injured, mine type, age at injury, and days lost were evaluated for each injury. Results - The majority of injuries occurred at surface mining facilities ([not, vert, similar] 60%) with fractures and sprains/strains being the most common injuries occurring to the major joints of the body. Nearly 50% of injuries occurred during ingress/egress, predominately during egress, and approximately 25% of injuries occurred during maintenance tasks. The majority of injuries occurred in relation to large trucks, wheel loaders, dozers, and conveyors/belts. The severity of injury was independent of age and the median days lost was seven days; however, there was a large range in severity. Impact on industry - From the data obtained in this study, several different research areas have been identified for future work, which include balance and stability control when descending ladders and equipment design for maintenance tasks. JF - Journal of Safety Research AU - Moore, Susan M AU - Porter, William L AU - Dempsey, Patrick G AD - National Institute for Occupational Safety and Health, USA, SMMoore@cdc.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 455 EP - 460 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 40 IS - 6 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - Age KW - Safety regulations KW - Injuries KW - Falls KW - Occupational safety KW - Mines KW - Maintenance KW - USA KW - safety engineering KW - Trucks KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21283637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Fall+from+equipment+injuries+in+U.S.+mining%3A+Identification+of+specific+research+areas+for+future+investigation&rft.au=Moore%2C+Susan+M%3BPorter%2C+William+L%3BDempsey%2C+Patrick+G&rft.aulast=Moore&rft.aufirst=Susan&rft.date=2009-12-01&rft.volume=40&rft.issue=6&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2009.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Age; Safety regulations; safety engineering; Falls; Injuries; Occupational safety; Trucks; Mines; Maintenance; USA DO - http://dx.doi.org/10.1016/j.jsr.2009.10.002 ER - TY - JOUR T1 - The Accurate Prediction of Protein Family from Amino Acid Sequence by Measuring Features of Sequence Fragments AN - 21278701; 11851573 AB - The rapid advances in proteomic analyses coupled with the completion of multiple genomes have led to an increased demand for determining protein functions. The first step is classification or prediction into families. A method was developed for the prediction of protein family based only on protein sequence using support vector machine (SVM) models. In these models, the amino acids were classified into three categories (apolar, polar, and charged). Consecutive fragments ranging from one to five were annotated by amino acid type to define the protein features of each protein. SVM models were constructed based on the protein features of a training set of proteins and then examined with an independent set of proteins. The approach was tested for 20 protein families from the iProClass database of Protein Information Resources (PIR). For two-class SVM models, an average prediction accuracy of 0.9985 was achieved, while for multi-class SVM models an accuracy of 0.9941 was achieved. This study demonstrates that SVM based methods can accurately recognize and predict the protein family to which a sequence belongs based solely on its primary ammo acid sequence. JF - Journal of Computational Biology AU - Hong, H AU - Hong, Q AU - Perkins, R AU - Shi, L AU - Fang, H AU - Su, Z AU - Dragan, Y AU - Fuscoe, J C AU - Tong, W AD - Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, Huixiao.Hong@fda.hhs.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1671 EP - 1688 PB - Mary Ann Liebert, Inc., 2 Madison Ave Larchmont NY 10538 USA, [mailto:liebert@pipeline.com] VL - 16 IS - 12 SN - 1066-5277, 1066-5277 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Databases KW - protein families KW - proteomics KW - Computer applications KW - Models KW - Amino acid sequence KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21278701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Deepwater+Horizon+Response+Workers+Exposure+Assessment+at+the+Source%3A+MC252+Well+No.+1&rft.au=Ahrenholz%2C+Steven+H%3BSylvain%2C+David+C&rft.aulast=Ahrenholz&rft.aufirst=Steven&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2011.575011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Genomes; Databases; protein families; proteomics; Computer applications; Amino acid sequence; Models DO - http://dx.doi.org/10.1089/cmb.2008.0115 ER - TY - JOUR T1 - beta-Lactam Resistance in Salmonella Strains Isolated from Retail Meats in the United States by the National Antimicrobial Resistance Monitoring System between 2002 and 2006 AN - 21252861; 11811778 AB - Ampicillin-resistant (Ampr) Salmonella enterica isolates (n = 344) representing 32 serotypes isolated from retail meats from 2002 to 2006 were tested for susceptibility to 21 other antimicrobial agents and screened for the presence of five beta-lactamase gene families (blaCMY, blaTEM, blaSHV, blaOXA, and blaCTX-M) and class 1 integrons. Among the Ampr isolates, 66.9% were resistant to five or more antimicrobials and 4.9% were resistant to 10 or more antimicrobials. Coresistance to other beta-lactams was noted for amoxicillin-clavulanic acid (55.5%), ceftiofur (50%), cefoxitin (50%), and ceftazidime (24.7%), whereas less than 5% of isolates were resistant to piperacillin-tazobactam (4.9%), cefotaxime (3.5%), ceftriaxone (2%), and aztreonam (1.2%). All isolates were susceptible to cefepime, imipenem, and cefquinome. No Salmonella producing extended-spectrum beta-lactamases was found in this study. Approximately 7% of the isolates displayed a typical multidrug-resistant (MDR)-AmpC phenotype, with resistance to ampicillin, chloramphenicol, streptomycin, sulfonamide, tetracycline, plus resistance to amoxicillin-clavulanic acid, cefoxitin, and ceftiofur and with decreased susceptibility to ceftriaxone (MIC 4 kg/ml). Pulsed-field gel electrophoresis results showed that several MDR clones were geographically dispersed in different types of meats throughout the five sampling years. Additionally, 50% of the isolates contained blaCMY, 47% carried blaTEM-1, and 2.6% carried both genes. Only 15% of the isolates harbored class I integrons carrying various combinations of aadA, aadB, and dfrA gene cassettes. The blaCMY, blaTEM, and class 1 integrons were transferable through conjugation and/or transformation. Our findings indicate that a varied spectrum of coresistance traits is present in Ampr Salmonella strains in the meat supply of the United States, with a continued predominance of blaCMY and blaTEM genes in beta-lactam-resistant isolates. JF - Applied and Environmental Microbiology AU - Zhao, S AU - Blickenstaff, K AU - Glenn, A AU - Ayers, S L AU - Friedman, S L AU - Abbott, J W AU - McDermott, P F AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland, shaohua.zhao@fda.hhs.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 7624 EP - 7630 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 75 IS - 24 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Ampicillin KW - Meat KW - Salmonella enterica KW - A 01330:Food Microbiology KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21252861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=beta-Lactam+Resistance+in+Salmonella+Strains+Isolated+from+Retail+Meats+in+the+United+States+by+the+National+Antimicrobial+Resistance+Monitoring+System+between+2002+and+2006&rft.au=Zhao%2C+S%3BBlickenstaff%2C+K%3BGlenn%2C+A%3BAyers%2C+S+L%3BFriedman%2C+S+L%3BAbbott%2C+J+W%3BMcDermott%2C+P+F&rft.aulast=Zhao&rft.aufirst=S&rft.date=2009-12-01&rft.volume=75&rft.issue=24&rft.spage=7624&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01158-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Meat; Salmonella enterica DO - http://dx.doi.org/10.1128/AEM.01158-09 ER - TY - JOUR T1 - Development and Analytical Validation of an Immunoassay for Quantifying Serum Anti-Pertussis Toxin Antibodies Resulting from Bordetella pertussis Infection AN - 21228382; 11811758 AB - Adequately sensitive and specific methods to diagnose pertussis in adolescents and adults are not widely available. Currently, no Food and Drug Administration-approved diagnostic assays are available for the serodiagnosis of Bordetella pertussis. Since concentrations of B. pertussis-specific antibodies tend to be high during the later phases of disease, a simple, rapid, easily transferable serodiagnostic test was developed. This article describes test development, initial evaluation of a prototype kit enzyme-linked immunosorbent assay (ELISA) in an interlaboratory collaborative study, and analytical validation. The data presented here demonstrate that the kit met all prespecified criteria for precision, linearity, and accuracy for samples with anti-pertussis toxin (PT) immunoglobulin G (IgG) antibody concentrations in the range of 50 to 150 ELISA units (EU)/ml, the range believed to be most relevant for serodiagnosis. The assay met the precision and linearity criteria for a wider range, namely, from 50 to 200 EU/ml; however, the accuracy criterion was not met at 200 EU/ml. When the newly adopted World Health Organization International Standard for pertussis antiserum (human) reference reagent was used to evaluate accuracy, the accuracy criteria were met from 50 to 200 international units/ml. In conclusion, the IgG anti-PT ELISA met all assay validation parameters within the range considered most relevant for serodiagnosis. This ELISA was developed and analytically validated as a user-friendly kit that can be used in both qualitative and quantitative formats. The technology for producing the kit is transferable to public health laboratories. JF - Clinical and Vaccine Immunology AU - Menzies, Sandra L AU - Kadwad, Vijay AU - Pawloski, Lucia C AU - Lin, Tsai-Lien AU - Baughman, Andrew L AU - Martin, Monte AU - Tondella, Maria Lucia C AU - Meade, Bruce D AD - Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, Sandra.Menzies@fda.hhs.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1781 EP - 1788 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 16 IS - 12 SN - 1556-679X, 1556-679X KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Adolescence KW - Data processing KW - Drugs KW - Enzyme-linked immunosorbent assay KW - Immunoglobulin G KW - Infection KW - International standards KW - Pertussis KW - Public health KW - Toxins KW - Bordetella pertussis KW - X 24310:Pharmaceuticals KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21228382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Development+and+Analytical+Validation+of+an+Immunoassay+for+Quantifying+Serum+Anti-Pertussis+Toxin+Antibodies+Resulting+from+Bordetella+pertussis+Infection&rft.au=Menzies%2C+Sandra+L%3BKadwad%2C+Vijay%3BPawloski%2C+Lucia+C%3BLin%2C+Tsai-Lien%3BBaughman%2C+Andrew+L%3BMartin%2C+Monte%3BTondella%2C+Maria+Lucia+C%3BMeade%2C+Bruce+D&rft.aulast=Menzies&rft.aufirst=Sandra&rft.date=2009-12-01&rft.volume=16&rft.issue=12&rft.spage=1781&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00248-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - International standards; Pertussis; Enzyme-linked immunosorbent assay; Data processing; Adolescence; Immunoglobulin G; Infection; Drugs; Toxins; Public health; Bordetella pertussis DO - http://dx.doi.org/10.1128/CVI.00248-09 ER - TY - JOUR T1 - The Impact of Self-Insuring for Workers' Compensation on the Incidence Rates of Worker Injury and Illness AN - 21227915; 11769522 AB - Objective: There is moderate evidence that workers in experience-rated firms sustain less injuries when compared with workers in firms that are not experience rated. This study aims to provide more insight on this issue. Methods: Panel data from the Bureau of Labor Statistics and National Academy of Social Insurance between 1999 and 2006 were used. A theoretical framework was developed, and a fixed effects vector decomposition model was estimated. Results: Self-insuring was positively associated with relatively low worker injury and illness incidence rates when compared with insuring (including experience rating and manually rating). After controlling for workforce characteristics, industrial composition, firm size, and state-specific laws, states with an above the median percentage of self-insured firms had incidence rates that were lower than rates in states with a below the median percentage of self-insured firms. Conclusion: A higher degree of experience rating seems to better align the economic incentive to invest in prevention and the intended outcome of reducing worker injury and illness. JF - Journal of Occupational and Environmental Medicine AU - Asfaw, A AU - Pana-Cryan, R AD - Center for Disease Control and Prevention, National Institute for Occupational Safety and Health, Office of the Director, Suite 9200, Patriots Plaza, 395 E Street, SW, Washington, DC 20201, USA, hqp0@cdc.gov Y1 - 2009/12// PY - 2009 DA - Dec 2009 SP - 1466 EP - 1473 VL - 51 IS - 12 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - workers' compensation KW - Injuries KW - Occupational safety KW - prevention KW - Economic incentives KW - Insurance KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21227915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=The+Impact+of+Self-Insuring+for+Workers%27+Compensation+on+the+Incidence+Rates+of+Worker+Injury+and+Illness&rft.au=Asfaw%2C+A%3BPana-Cryan%2C+R&rft.aulast=Asfaw&rft.aufirst=A&rft.date=2009-12-01&rft.volume=51&rft.issue=12&rft.spage=1466&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181c16373 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - workers' compensation; Injuries; Occupational safety; prevention; Insurance; Economic incentives; Occupational health DO - http://dx.doi.org/10.1097/JOM.0b013e3181c16373 ER - TY - JOUR T1 - Hurdles and Leaps for Protein Therapeutics AN - 1780522370; PQ0002828616 AB - Cytokines encompass a wide variety of proteins that can trigger many cellular activities. An important set of cytokines modulate inflammatory responses (inflammatory cytokines). These molecules have potent biological activities and have been a major focus for protein drug development. There have been both successes and failures in this area. Initial hurdles, such as limited manufacturing capacity, have now been largely overcome. However clinical development remains a challenge. On the basis of the history of cytokine therapeutics, a number of strategies for future drug development are considered. JF - Annals of the New York Academy of Sciences AU - Kozlowski, Steven AU - Cherney, Barry AU - Donnelly, Raymond P AD - Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, Maryland, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 146 EP - 160 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 1182 IS - 1 SN - 0077-8923, 0077-8923 KW - Environment Abstracts KW - Historical account KW - Proteins KW - Drugs KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780522370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Hurdles+and+Leaps+for+Protein+Therapeutics&rft.au=Kozlowski%2C+Steven%3BCherney%2C+Barry%3BDonnelly%2C+Raymond+P&rft.aulast=Kozlowski&rft.aufirst=Steven&rft.date=2009-12-01&rft.volume=1182&rft.issue=1&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.2009.05158.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Historical account; Proteins; Drugs DO - http://dx.doi.org/10.1111/j.1749-6632.2009.05158.x ER - TY - JOUR T1 - An Overview of Cytokines and Cytokine Antagonists as Therapeutic Agents AN - 1780517266; PQ0002828624 AB - Cytokine-based therapies have the potential to provide novel treatments for cancer, autoimmune diseases, and many types of infectious disease. However, to date, the full clinical potential of cytokines as drugs has been limited by a number of factors. To discuss these limitations and explore ways to overcome them, the FDA partnered with the New York Academy of Sciences in March 2009 to host a two-day forum to discuss more effective ways to harness the clinical potential of cytokines and cytokine antagonists as therapeutic agents. The first day was focused primarily on the use of recombinant cytokines as therapeutic agents for treatment of human diseases. The second day focused largely on the use of cytokine antagonists as therapeutic agents for treatment of human diseases. This issue of the Annals includes more than a dozen papers that summarize much of the information that was presented during this very informative two-day conference. JF - Annals of the New York Academy of Sciences AU - Donnelly, Raymond P AU - Young, Howard A AU - Rosenberg, Amy S AD - Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA. Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1 EP - 13 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 1182 IS - 1 SN - 0077-8923, 0077-8923 KW - Immunology Abstracts; Environment Abstracts KW - ANW, USA, New York KW - Infectious diseases KW - Conferences KW - Autoimmune diseases KW - FDA KW - Drugs KW - Cancer KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780517266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=An+Overview+of+Cytokines+and+Cytokine+Antagonists+as+Therapeutic+Agents&rft.au=Donnelly%2C+Raymond+P%3BYoung%2C+Howard+A%3BRosenberg%2C+Amy+S&rft.aulast=Donnelly&rft.aufirst=Raymond&rft.date=2009-12-01&rft.volume=1182&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1111%2Fj.1749-6632.2009.05382.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Conferences; Infectious diseases; Autoimmune diseases; FDA; Drugs; Cancer; ANW, USA, New York DO - http://dx.doi.org/10.1111/j.1749-6632.2009.05382.x ER - TY - JOUR T1 - The Role of p53 in Silica-Induced Cellular and Molecular Responses Associated with Carcinogenesis AN - 1777117675; 12569118 AB - Crystalline silica (silica), a suspected human carcinogen, produces an increase in reactive oxygen species (ROS) when fractured using mechanical tools used in several occupations. Although ROS has been linked to apoptosis, DNA damage, and carcinogenesis, the role of enhanced ROS production by silica in silica-induced carcinogenesis is not completely understood. The goal of this study was to compare freshly fractured and aged silica-induced molecular alterations in human immortalized/ transformed bronchial epithelial cells (BEAS-IIB) and lung cancer cells with altered (H460) or deficient (H1299) p53 expression. Exposure to freshly fractured or aged silica produced divergent cellular responses in certain downstream cellular events, including ROS production, apoptosis, cell cycle and chromosomal changes, and gene expression. ROS production increased significantly following exposure to freshly fractured silica compared to aged silica in BEAS-IIB and H460 cells. Apoptosis showed a comparable enhanced level of induction with freshly fractured or aged silica in both cancer lines with p53 functional changes. p53 protein was present in the BEAS-IIB and was absent in cancer cell lines after silica exposure. Exposure to freshly fractured silica also resulted in a rise in aneuploidy in cancer cells with a significantly greater increase in p53-deficient cells. Cytogenetic analysis demonstrated increased metaphase spreads, chromosome breakage, rearrangements, and endoreduplication in both cancer cells. These results suggest that altered and deficient p53 affects the cellular response to freshly fractured silica exposure, and thereby enhances susceptibility and augments cell proliferation and lung cancer development. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Gwinn, Maureen R AU - Leonard, Stephen S AU - Sargent, Linda M AU - Lowry, David T AU - McKinstry, Kimberly AU - Meighan, Terry AU - Reynolds, Steve H AU - Kashon, Michael AU - Castranova, Vince AU - Vallyathan, Val AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA Y1 - 2009/12// PY - 2009 DA - December 2009 SP - 1509 EP - 1519 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 72 IS - 23-24 SN - 1528-7394, 1528-7394 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Damage KW - Apoptosis KW - Human KW - Carcinogens KW - Cancer KW - Spreads KW - Gene expression KW - Cellular KW - Chromosomes KW - Breakage KW - Alterations KW - Occupation KW - Crystal structure KW - Proteins KW - Deoxyribonucleic acid KW - Lungs KW - Silicon dioxide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777117675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Correcting+Diacetyl+Concentrations+from+Air+Samples+Collected+with+NIOSH+Method+2557&rft.au=Cox-Ganser%2C+Jean%3BGanser%2C+Gary%3BSaito%2C+Rena%3BHobbs%2C+Gerald%3BBoylstein%2C+Randy%3BHendricks%2C+Warren%3BSimmons%2C+Michael%3BEide%2C+Mary%3BKullman%2C+Greg%3BPiacitelli%2C+Chris&rft.aulast=Cox-Ganser&rft.aufirst=Jean&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2011.540168 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1080/15287390903129291 ER - TY - CPAPER T1 - Initiation and Polymerization of Bacterial Polysialic Acids on Hydrophobic Acceptors. T2 - 20th International Symposium of Glycoconjugates (GLYCO XX) AN - 42244385; 5597762 JF - 20th International Symposium of Glycoconjugates (GLYCO XX) AU - Vann, Willie AU - Vionnet, Justine AU - Peterson, Dwight AU - Arakere, Gayathri Y1 - 2009/11/29/ PY - 2009 DA - 2009 Nov 29 KW - Hydrophobicity KW - Polymerization KW - Polysialic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42244385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+International+Symposium+of+Glycoconjugates+%28GLYCO+XX%29&rft.atitle=Initiation+and+Polymerization+of+Bacterial+Polysialic+Acids+on+Hydrophobic+Acceptors.&rft.au=Vann%2C+Willie%3BVionnet%2C+Justine%3BPeterson%2C+Dwight%3BArakere%2C+Gayathri&rft.aulast=Vann&rft.aufirst=Willie&rft.date=2009-11-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+International+Symposium+of+Glycoconjugates+%28GLYCO+XX%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glyco20.org/pdfs/ScientifciProgramUpdate.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A difficult balance--pain management, drug safety, and the FDA. AN - 734156780; 19940297 JF - The New England journal of medicine AU - Woodcock, Janet AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2009/11/26/ PY - 2009 DA - 2009 Nov 26 SP - 2105 EP - 2107 VL - 361 IS - 22 KW - Analgesics KW - 0 KW - Analgesics, Opioid KW - Acetaminophen KW - 362O9ITL9D KW - Abridged Index Medicus KW - Index Medicus KW - Analgesics, Opioid -- poisoning KW - United States Food and Drug Administration KW - Humans KW - Acetaminophen -- poisoning KW - Analgesics, Opioid -- therapeutic use KW - Acetaminophen -- therapeutic use KW - Drug Overdose -- epidemiology KW - Analgesics, Opioid -- adverse effects KW - United States -- epidemiology KW - Advisory Committees KW - Pain -- drug therapy KW - Analgesics -- poisoning KW - Drug and Narcotic Control -- legislation & jurisprudence KW - Analgesics -- therapeutic use KW - Analgesics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734156780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=A+difficult+balance--pain+management%2C+drug+safety%2C+and+the+FDA.&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2009-11-26&rft.volume=361&rft.issue=22&rft.spage=2105&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMp0908913 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-07 N1 - Date created - 2009-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1056/NEJMp0908913 ER - TY - JOUR T1 - Influence of cytokine gene variations on immunization to childhood vaccines AN - 754565034; 13403632 AB - The magnitude of the immune response to vaccinations can be influenced by genetic variability. In the present study, we aimed to investigate whether cytokine or cytokine receptor gene polymorphisms were associated with variations in the immune response to childhood vaccination. The study group consisted of 141 healthy infants who had been immunized with hepatitis B vaccine (HBV), 7-valent pneumococcal conjugate (PCV7), and diphtheria, tetanus, acellular pertussis (DTaP) vaccines according to standard childhood immunization schedules. Genotype analysis was performed on genomic DNA using a 5' nuclease PCR assay. Post vaccination total, isotypic, and antigen-specific serum antibody levels were measured using multiplex immunoassays. Significant associations were observed between SNPs in the TNFa, IL-12B, IL-4Ra, and IL-10 genes and vaccine-specific immune responses (p < 0.05). In addition, SNPs in the IL-1b, TNFa, IL-2, IL-4, IL-10, IL-4Ra, and IL-12B genes were associated with variations in serum levels of immunoglobulins (IgG, IgA, IgM) and IgG isotypes (IgG1-IgG3) (p < 0.05). These data suggest that genetic variations in cytokine genes can influence vaccine-induced immune responses in infants, which in turn may influence vaccine efficacy. JF - Vaccine AU - Yucesoy, Berran AU - Johnson, Victor J AU - Fluharty, Kara AU - Kashon, Michael L AU - Slaven, James E AU - Wilson, Nevin W AU - Weissman, David N AU - Biagini, Raymond E AU - Germolec, Dori R AU - Luster, Michael I AD - Toxicology and Molecular Biology Branch, CDC/NIOSH, Morgantown, WV, United States Y1 - 2009/11/23/ PY - 2009 DA - 2009 Nov 23 SP - 6991 EP - 6997 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 27 IS - 50 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Children KW - Hepatitis B virus KW - Vaccines KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754565034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Influence+of+cytokine+gene+variations+on+immunization+to+childhood+vaccines&rft.au=Yucesoy%2C+Berran%3BJohnson%2C+Victor+J%3BFluharty%2C+Kara%3BKashon%2C+Michael+L%3BSlaven%2C+James+E%3BWilson%2C+Nevin+W%3BWeissman%2C+David+N%3BBiagini%2C+Raymond+E%3BGermolec%2C+Dori+R%3BLuster%2C+Michael+I&rft.aulast=Yucesoy&rft.aufirst=Berran&rft.date=2009-11-23&rft.volume=27&rft.issue=50&rft.spage=6991&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2009.09.076 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Vaccines; Hepatitis B virus DO - http://dx.doi.org/10.1016/j.vaccine.2009.09.076 ER - TY - JOUR T1 - Lab-on-a-chip for botulinum neurotoxin a (BoNT-A) activity analysis. AN - 733862010; 19865736 AB - A Lab-on-a-chip (LOC) was designed, fabricated and tested for the in vitro detection of botulinum neurotoxin serotype A (BoNT-A) activity using an assay that measures cleavage of a fluorophore-tagged peptide substrate specific for BoNT-A (SNAP-25) by the toxin light chain (LcA). LcA cleavage was detected by Förster Resonance Energy Transfer (FRET) fluorescence. FRET fluorescence was measured by a newly developed portable charge-coupled device (CCD) fluorescent detector equipped with multi-wavelength light-emitting diodes (LED) illumination. An eight V-junction microchannel device for BoNTs activity assays was constructed using Laminated Object Manufacturing (LOM) technology. The six-layer device was fabricated with a Poly(methyl methacrylate (PMMA) core and five polycarbonate (PC) layers micromachined by CO2 laser. The LOC is operated by syringe and is equipped with reagents, sample wells, reaction wells, diffusion traps (to avoid cross contamination among channels) and waste reservoirs. The system was detected LcA at concentrations as low as 0.5 nM, which is the reported sensitivity of the SNAP-25 in vitro cleavage assay. Combined with our CCD detector, the simple point of care system enables the detection of BoNTs activity and may be useful for the performance of other complex medical assays without a laboratory. This approach may realize the potential to enhance the quality of health care delivery for underserved populations. JF - Lab on a chip AU - Sun, Steven AU - Ossandon, Miguel AU - Kostov, Yordan AU - Rasooly, Avraham AD - Division of Biology, Office of Science and Engineering Laboratories, FDA, NIH/NCI, Silver Spring, MD 20993, USA. Y1 - 2009/11/21/ PY - 2009 DA - 2009 Nov 21 SP - 3275 EP - 3281 VL - 9 IS - 22 SN - 1473-0197, 1473-0197 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Index Medicus KW - Fluorescence Resonance Energy Transfer KW - Lab-On-A-Chip Devices KW - Botulinum Toxins, Type A -- analysis KW - Microchip Analytical Procedures -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733862010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lab+on+a+chip&rft.atitle=Lab-on-a-chip+for+botulinum+neurotoxin+a+%28BoNT-A%29+activity+analysis.&rft.au=Sun%2C+Steven%3BOssandon%2C+Miguel%3BKostov%2C+Yordan%3BRasooly%2C+Avraham&rft.aulast=Sun&rft.aufirst=Steven&rft.date=2009-11-21&rft.volume=9&rft.issue=22&rft.spage=3275&rft.isbn=&rft.btitle=&rft.title=Lab+on+a+chip&rft.issn=14730197&rft_id=info:doi/10.1039%2Fb912097a LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-29 N1 - Date created - 2009-10-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 1992 Oct;11(10):3577-83 [1396558] Microbiol Rev. 1992 Mar;56(1):80-99 [1579114] Nature. 1993 Sep 9;365(6442):160-3 [8103915] Cell. 1993 Oct 8;75(1):1-4 [8402889] Eur J Biochem. 1993 Nov 1;217(3):965-71 [8223654] J Biol Chem. 1993 Nov 15;268(32):23784-7 [8226912] J Physiol Paris. 1993;87(2):107-15 [8305898] Electrophoresis. 1999 Apr-May;20(4-5):727-31 [10344240] Appl Environ Microbiol. 2005 Jul;71(7):3935-41 [16000807] J Immunol Methods. 2005 Jun;301(1-2):164-72 [15979637] Croat Med J. 2005 Aug;46(4):491-7 [16100750] Biomed Microdevices. 2005 Sep;7(3):205-11 [16133808] Methods. 2005 Sep;37(1):65-72 [16202623] J Appl Toxicol. 1999 Dec;19 Suppl 1:S13-7 [10594893] Electrophoresis. 2002 Mar;23(6):858-67 [11920870] Anal Chem. 2002 Apr 15;74(8):1798-804 [11985310] J Immunol Methods. 2002 May 1;263(1-2):35-41 [12009202] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11346-50 [12177434] Anal Bioanal Chem. 2003 Oct;377(3):469-77 [12811462] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13621-5 [14573702] J Food Prot. 2004 Jan;67(1):203-6 [14717376] Lab Chip. 2003 Nov;3(4):248-52 [15007454] Lab Chip. 2004 Oct;4(5):438-45 [15472727] Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14701-6 [15465919] Emerg Infect Dis. 2005 Oct;11(10):1578-83 [16318699] Appl Environ Microbiol. 2005 Dec;71(12):7897-903 [16332765] J Biomol Screen. 2005 Dec;10(8):788-94 [16234350] Appl Environ Microbiol. 2006 Feb;72(2):1231-8 [16461671] Anal Biochem. 2006 Apr 1;351(1):84-92 [16500606] Anal Biochem. 2006 Jun 15;353(2):248-56 [16620745] J Comb Chem. 2006 Jul-Aug;8(4):513-21 [16827563] Nature. 2006 Jul 27;442(7101):412-8 [16871209] Diagn Microbiol Infect Dis. 2006 Nov;56(3):225-32 [16839735] Anal Sci. 2007 Jan;23(1):5-10 [17213615] Diagn Microbiol Infect Dis. 2007 Mar;57(3):243-9 [17141460] Anal Chim Acta. 2007 Mar 21;587(1):1-8 [17386746] Crit Rev Microbiol. 2007 Apr-Jun;33(2):109-25 [17558660] J Vet Diagn Invest. 2007 Jul;19(4):349-54 [17609342] J Immunol Methods. 2007 Aug 31;325(1-2):78-87 [17659299] Nature. 2007 Dec 20;450(7173):1235-9 [18097410] Appl Environ Microbiol. 2008 Feb;74(3):653-9 [18083881] Appl Environ Microbiol. 2008 Jul;74(14):4309-13 [18515481] Int J Food Microbiol. 2008 Aug 15;126(1-2):135-9 [18571757] Biosens Bioelectron. 2008 Dec 1;24(4):618-25 [18644709] Lab Chip. 2008 Nov;8(11):1793-800 [18941677] Protein Pept Lett. 2008;15(10):1100-6 [19075822] Anal Bioanal Chem. 2009 May;394(2):499-505 [19290511] Biomed Microdevices. 2009 Aug;11(4):883-92 [19387837] J Chromatogr A. 2009 Nov 20;1216(47):8289-95 [19497576] Lancet. 1990 Feb 17;335(8686):421 [1968156] Nature. 1992 Oct 29;359(6398):832-5 [1331807] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/b912097a ER - TY - JOUR T1 - A Case-Control Study of Smoking and Bladder Cancer Risk: Emergent Patterns Over Time AN - 899130172; 13761815 AB - Background Cigarette smoking is a well-established risk factor for bladder cancer. The effects of smoking duration, intensity (cigarettes per day), and total exposure (pack-years); smoking cessation; exposure to environmental tobacco smoke; and changes in the composition of tobacco and cigarette design over time on risk of bladder cancer are unclear. Methods We examined bladder cancer risk in relation to smoking practices based on interview data from a large, population-based case-control study conducted in Maine, New Hampshire, and Vermont from 2001 to 2004 (N = 1170 urothelial carcinoma case patients and 1413 control subjects). We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression. To examine changes in smoking-induced bladder cancer risk over time, we compared odds ratios from New Hampshire residents in this study (305 case patients and 335 control subjects) with those from two case-control studies conducted in New Hampshire in 1994-1998 and in 1998-2001 (843 case patients and 1183 control subjects). Results Regular and current cigarette smokers had higher risks of bladder cancer than never-smokers (for regular smokers, OR = 3.0, 95% CI = 2.4 to 3.6; for current smokers, OR = 5.2, 95% CI = 4.0 to 6.6). In New Hampshire, there was a statistically significant increasing trend in smoking-related bladder cancer risk over three consecutive periods (1994-1998, 1998-2001, and 2002-2004) among former smokers (OR = 1.4, 95% CI = 1.0 to 2.0; OR = 2.0, 95% CI = 1.4 to 2.9; and OR = 2.6, 95% CI = 1.7 to 4.0, respectively) and current smokers (OR = 2.9, 95% CI = 2.0 to 4.2; OR = 4.2, 95% CI = 2.8 to 6.3; OR = 5.5, 95% CI = 3.5 to 8.9, respectively) (P for homogeneity of trends over time periods = .04). We also observed that within categories of intensity, odds ratios increased approximately linearly with increasing pack-years smoked, but the slope of the increasing trend declined with increasing intensity. Conclusions Smoking-related risks of bladder cancer appear to have increased in New Hampshire since the mid-1990s. Based on our modeling of pack-years and intensity, smoking fewer cigarettes over a long time appears more harmful than smoking more cigarettes over a shorter time, for equal total pack-years of cigarettes smoked. JF - Journal of the National Cancer Institute AU - Baris, Dalsu AU - Karagas, Margaret R AU - Verrill, Castine AU - Johnson, Alison AU - Andrew, Angeline S AU - Marsit, Carmen J AU - Schwenn, Molly AU - Colt, Joanne S AU - Cherala, Sai AU - Samanic, Claudine AU - Waddell, Richard AU - Cantor, Kenneth P AU - Schned, Alan AU - Rothman, Nathaniel AU - Lubin, Jay AU - Fraumeni, Joseph F AU - Hoover, Robert N AU - Kelsey, Karl T AU - Silverman, Debra T AD - Affiliations of authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (DB, JSC, KPC, NR, CS, JL, JFF, RNH, DTS); Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH (MRK, ASA, RW, AS); Department of Community Health and Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island (CJM, KTK); Maine Cancer Registry, Augusta, ME (CV, MS); New Hampshire Cancer Registry, Concord, NH (SC); Vermont Cancer Registry, Burlington, VT (AJ), barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov barisd@mail.nih.gov Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 SP - 1553 EP - 1561 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 101 IS - 22 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Cigarettes KW - Cancer KW - urinary bladder KW - Passive smoking KW - Cigarette smoking KW - Tobacco KW - USA, Maine KW - USA, New Hampshire KW - USA, Vermont KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899130172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Evaluation+of+Nano-+and+Submicron+Particle+Penetration+through+Ten+Nonwoven+Fabrics+Using+a+Wind-Driven+Approach&rft.au=Gao%2C+Pengfei%3BJaques%2C+Peter+A%3BHsiao%2C+Ta-Chih%3BShepherd%2C+Angie%3BEimer%2C+Benjamin+C%3BYang%2C+Mengshi%3BMiller%2C+Adam%3BGupta%2C+Bhupender%3BShaffer%2C+Ronald&rft.aulast=Gao&rft.aufirst=Pengfei&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2010.515554 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - urinary bladder; Passive smoking; Cigarettes; Cigarette smoking; Tobacco; Cancer; USA, Maine; USA, New Hampshire; USA, Vermont DO - http://dx.doi.org/10.1093/jnci/djp361 ER - TY - CPAPER T1 - The Emerging Risk of Babesiosis from Transfusion in the United States T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42223926; 5592241 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Epstein, Jay Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - USA KW - Transfusion KW - Babesiosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42223926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=The+Emerging+Risk+of+Babesiosis+from+Transfusion+in+the+United+States&rft.au=Epstein%2C+Jay&rft.aulast=Epstein&rft.aufirst=Jay&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Health Preparation for Mass Migrations: Current Efforts in Tracking Diseases and Containing Outbreaks at Mass Travel Events T2 - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 42222240; 5592017 JF - 58th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Fleischauer, Aaron Y1 - 2009/11/18/ PY - 2009 DA - 2009 Nov 18 KW - Migration KW - Public health KW - Outbreaks KW - Travel KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42222240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Public+Health+Preparation+for+Mass+Migrations%3A+Current+Efforts+in+Tracking+Diseases+and+Containing+Outbreaks+at+Mass+Travel+Events&rft.au=Fleischauer%2C+Aaron&rft.aulast=Fleischauer&rft.aufirst=Aaron&rft.date=2009-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/AM/Template.cfm?Section=Meeting_Archives&Template =/CM/ContentDisplay.cfm&ContentID=2309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enrollment of Women and Ethnic Minorities and Their Drop-out Profi les: More Than a Quarter of a Century Experience (1973-2001) in Antihypertensive Drug Trials T2 - 2009 American Heart Association Scientific Sessions AN - 42234174; 5600480 JF - 2009 American Heart Association Scientific Sessions AU - Lemtouni, Salma AU - Willard, James Y1 - 2009/11/14/ PY - 2009 DA - 2009 Nov 14 KW - Drugs KW - Antihypertensives KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42234174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Comparison+of+Air+Sampling+Methods+for+Aerosolized+Spores+of+B.+anthracis+Sterne&rft.au=Estill%2C+Cheryl+Fairfield%3BBaron%2C+Paul+A%3BBeard%2C+Jeremy+K%3BHein%2C+Misty+J%3BLarsen%2C+Lloyd+D%3BDeye%2C+Gregory+J%3BRose%2C+Laura%3BHodges%2C+Lisa&rft.aulast=Estill&rft.aufirst=Cheryl&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2011.556981 L2 - http://www.nxtbook.com/tristar/tristar/aha_09finalprogram/#/0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Residue depletion of albendazole and its metabolites in the muscle tissue of large mouth and hybrid striped bass after oral administration. AN - 734100095; 19406409 AB - The residue depletion profiles of albendazole (ABZ) and its major metabolites: albendazole sulfoxide (ABZ-SO), albendazole sulfone (ABZ-SO(2)) and albendazole aminosulfone (ABZ-2-NH(2)SO(2)) were studied in the muscle tissues of large mouth (LMB) and hybrid striped bass (HSB). A single oral dose of 10mg/kg albendazole was given to the two fish species via intra-gastric tube. The muscle tissues with adhering skin were collected at 8, 16, 24, 48, 72, 96 and 120h post dose from both species. The samples were homogenized in dry ice and subjected to extraction and cleanup procedures. The final sample extracts were analyzed by high performance liquid chromatography. The results indicate that both ABZ and its pharmacologically active metabolite ABZ-SO were retained longer in LMB than in HSB after oral treatment. Albendazole was detectable until 8h or 6.7 degree days ( degrees D) and 48h (40 degrees D) in HSB and LMB, respectively. However, ABZ-SO was detectable up to 48h (40 degrees D) and 96h (80 degrees D) in HSB and LMB, respectively. Among the inactive metabolites, ABZ-SO(2) was present in both fish species; however, ABZ-2-NH(2)SO(2) was detected only in LMB. JF - Journal of chromatography. A AU - Shaikh, Badar AU - Rummel, Nathan AU - Gieseker, Charles AU - Cheely, Christie-Sue AU - Reimschuessel, Renate AD - Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, MD 20708, USA. Badaruddin.Shaikh@fda.hhs.gov Y1 - 2009/11/13/ PY - 2009 DA - 2009 Nov 13 SP - 8173 EP - 8176 VL - 1216 IS - 46 KW - Albendazole KW - F4216019LN KW - Index Medicus KW - Administration, Oral KW - Animals KW - Muscles -- chemistry KW - Drug Residues -- analysis KW - Muscles -- metabolism KW - Drug Residues -- metabolism KW - Chromatography, High Pressure Liquid -- methods KW - Albendazole -- administration & dosage KW - Albendazole -- metabolism KW - Albendazole -- analysis KW - Bass UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734100095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+A&rft.atitle=Residue+depletion+of+albendazole+and+its+metabolites+in+the+muscle+tissue+of+large+mouth+and+hybrid+striped+bass+after+oral+administration.&rft.au=Shaikh%2C+Badar%3BRummel%2C+Nathan%3BGieseker%2C+Charles%3BCheely%2C+Christie-Sue%3BReimschuessel%2C+Renate&rft.aulast=Shaikh&rft.aufirst=Badar&rft.date=2009-11-13&rft.volume=1216&rft.issue=46&rft.spage=8173&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+A&rft.issn=1873-3778&rft_id=info:doi/10.1016%2Fj.chroma.2009.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-06 N1 - Date created - 2009-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.chroma.2009.04.009 ER - TY - JOUR T1 - Simultaneous screening and confirmation of multiple classes of drug residues in fish by liquid chromatography-ion trap mass spectrometry. AN - 734100047; 19616215 AB - LC-ion trap mass spectrometry was used to screen and confirm 38 compounds from a variety of drug classes in four species of fish: trout, salmon, catfish, and tilapia. Samples were extracted with acetonitrile and hexane. The acetonitrile phase was evaporated, redissolved in water and acetonitrile, and analyzed by gradient chromatography on a phenyl column. MS(2) or MS(3) spectra were monitored for each compound. Qualitative method performance was evaluated by the analysis over several days of replicate samples of control fish, fish fortified with a drug mixture at 1 ppm, 0.1 ppm and 0.01 ppm, and fish dosed with a representative from each drug class. Half of the 38 drugs were confirmed at 0.01 ppm, the lowest fortification level. This included all of the quinolones and fluoroquinolones, the macrolides, malachite green, and most of the imidazoles. Florfenicol amine, metronidazole, sulfonamides, tetracyclines, and most of the betalactams were confirmed at 0.1 ppm. Ivermectin and penicillin G were only detectable in the 1 ppm fortified samples. With the exception of amoxicillin, emamectin, metronidazole, and tylosin, residue presence was confirmed in all the dosed fish. JF - Journal of chromatography. A AU - Smith, Shani AU - Gieseker, Charles AU - Reimschuessel, Renate AU - Decker, Christie-Sue AU - Carson, Mary C AD - Office of Research, Center for Veterinary Medicine, US Food & Drug Administration, Laurel, MD 20708, USA. Y1 - 2009/11/13/ PY - 2009 DA - 2009 Nov 13 SP - 8224 EP - 8232 VL - 1216 IS - 46 KW - Veterinary Drugs KW - 0 KW - Index Medicus KW - Animals KW - Fishes KW - Veterinary Drugs -- analysis KW - Chromatography, Liquid -- methods KW - Drug Residues -- analysis KW - Food Contamination -- analysis KW - Mass Spectrometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734100047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+A&rft.atitle=Simultaneous+screening+and+confirmation+of+multiple+classes+of+drug+residues+in+fish+by+liquid+chromatography-ion+trap+mass+spectrometry.&rft.au=Smith%2C+Shani%3BGieseker%2C+Charles%3BReimschuessel%2C+Renate%3BDecker%2C+Christie-Sue%3BCarson%2C+Mary+C&rft.aulast=Smith&rft.aufirst=Shani&rft.date=2009-11-13&rft.volume=1216&rft.issue=46&rft.spage=8224&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+A&rft.issn=1873-3778&rft_id=info:doi/10.1016%2Fj.chroma.2009.06.077 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-06 N1 - Date created - 2009-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.chroma.2009.06.077 ER - TY - CPAPER T1 - Development of Roof-Bolting Machine Bit and Chuck Isolators for Drilling Noise Reduction T2 - 2009 ASME International Mechanical Engineering Congress and Exposition (IMECE 2009) AN - 42143514; 5555397 JF - 2009 ASME International Mechanical Engineering Congress and Exposition (IMECE 2009) AU - Peterson, Jeffrey AU - Kovalchik, Peter AU - Yantek, David Y1 - 2009/11/13/ PY - 2009 DA - 2009 Nov 13 KW - Noise reduction KW - Drilling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42143514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+ASME+International+Mechanical+Engineering+Congress+and+Exposition+%28IMECE+2009%29&rft.atitle=Development+of+Roof-Bolting+Machine+Bit+and+Chuck+Isolators+for+Drilling+Noise+Reduction&rft.au=Peterson%2C+Jeffrey%3BKovalchik%2C+Peter%3BYantek%2C+David&rft.aulast=Peterson&rft.aufirst=Jeffrey&rft.date=2009-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+ASME+International+Mechanical+Engineering+Congress+and+Exposition+%28IMECE+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asmeconferences.org/Congress09/TechnicalProgramOverview.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Vibration as a Noise Source on Vibrating Screens T2 - 2009 ASME International Mechanical Engineering Congress and Exposition (IMECE 2009) AN - 42140001; 5555398 JF - 2009 ASME International Mechanical Engineering Congress and Exposition (IMECE 2009) AU - Yantek, Dave AU - Camargo, Hugo Y1 - 2009/11/13/ PY - 2009 DA - 2009 Nov 13 KW - Vibration KW - Noise levels KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42140001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+ASME+International+Mechanical+Engineering+Congress+and+Exposition+%28IMECE+2009%29&rft.atitle=Structural+Vibration+as+a+Noise+Source+on+Vibrating+Screens&rft.au=Yantek%2C+Dave%3BCamargo%2C+Hugo&rft.aulast=Yantek&rft.aufirst=Dave&rft.date=2009-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+ASME+International+Mechanical+Engineering+Congress+and+Exposition+%28IMECE+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asmeconferences.org/Congress09/TechnicalProgramOverview.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of Beamforming Processing Techniques for Low Frequency Noise Source Identification in Mining Equipment T2 - 2009 ASME International Mechanical Engineering Congress and Exposition (IMECE 2009) AN - 42138615; 5555403 JF - 2009 ASME International Mechanical Engineering Congress and Exposition (IMECE 2009) AU - Camargo, Hugo AU - Ravetta, Patricio AU - Burdisso, Ricardo AU - Smith, Adam Y1 - 2009/11/13/ PY - 2009 DA - 2009 Nov 13 KW - Mining equipment KW - Noise levels KW - Mining KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42138615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Evaluation+of+the+Filtration+Performance+of+NIOSH-Approved+N95+Filtering+Facepiece+Respirators+by+Photometric+and+Number-Based+Test+Methods&rft.au=Rengasamy%2C+Samy%3BMiller%2C+Adam%3BEimer%2C+Benjamin+C&rft.aulast=Rengasamy&rft.aufirst=Samy&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2010.515556 L2 - http://www.asmeconferences.org/Congress09/TechnicalProgramOverview.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation Managers and Supervisors TIG Business Meeting and Think Tank: How to Manage Evaluations in Lean Economic Times T2 - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AN - 42295934; 5624074 JF - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AU - Maxwell, Ann AU - Feldman, Laura Y1 - 2009/11/11/ PY - 2009 DA - 2009 Nov 11 KW - Economics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42295934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.atitle=Evaluation+Managers+and+Supervisors+TIG+Business+Meeting+and+Think+Tank%3A+How+to+Manage+Evaluations+in+Lean+Economic+Times&rft.au=Maxwell%2C+Ann%3BFeldman%2C+Laura&rft.aulast=Maxwell&rft.aufirst=Ann&rft.date=2009-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eval.org/search09/allschedule.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Comprehensive Cancer Control: National and State Perspectives Methods, Techniques and Tools T2 - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AN - 42273117; 5623625 JF - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AU - Rochester, Phyllis AU - Porterfield, Deborah AU - Moore, Angela AU - Yassine, May AU - Holden, Debra AU - Lowry, Garry AU - Soloe, Cindy Y1 - 2009/11/11/ PY - 2009 DA - 2009 Nov 11 KW - Cancer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42273117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.atitle=Evaluation+of+Comprehensive+Cancer+Control%3A+National+and+State+Perspectives+Methods%2C+Techniques+and+Tools&rft.au=Rochester%2C+Phyllis%3BPorterfield%2C+Deborah%3BMoore%2C+Angela%3BYassine%2C+May%3BHolden%2C+Debra%3BLowry%2C+Garry%3BSoloe%2C+Cindy&rft.aulast=Rochester&rft.aufirst=Phyllis&rft.date=2009-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eval.org/search09/allschedule.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Planning Infrastructure Changes in Complex Systems T2 - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AN - 42269638; 5623536 JF - 2009 Annual Conference of the American Evaluation Association (Evaluation 2009) AU - Brodowski, Melissa Y1 - 2009/11/11/ PY - 2009 DA - 2009 Nov 11 KW - Infrastructure KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42269638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.atitle=Planning+Infrastructure+Changes+in+Complex+Systems&rft.au=Brodowski%2C+Melissa&rft.aulast=Brodowski&rft.aufirst=Melissa&rft.date=2009-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+American+Evaluation+Association+%28Evaluation+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.eval.org/search09/allschedule.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Progress in Implementation of Quality by Design - An FDA Perspective T2 - 2009 AIChE Annual Meeting (AIChE 2009) AN - 42172374; 5570078 JF - 2009 AIChE Annual Meeting (AIChE 2009) AU - Moore, Christine Y1 - 2009/11/08/ PY - 2009 DA - 2009 Nov 08 KW - FDA KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42172374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+AIChE+Annual+Meeting+%28AIChE+2009%29&rft.atitle=Progress+in+Implementation+of+Quality+by+Design+-+An+FDA+Perspective&rft.au=Moore%2C+Christine&rft.aulast=Moore&rft.aufirst=Christine&rft.date=2009-11-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+AIChE+Annual+Meeting+%28AIChE+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://aiche.confex.com/aiche/2009/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Strategies for the Co-Development of Drugs and Diagnostics - An FDA Perspective on Diagnostics Regulation in Personalized Medicine T2 - 4th annual European Biomarkers Summit AN - 42562272; 5472651 JF - 4th annual European Biomarkers Summit AU - Kalush, Francis Y1 - 2009/11/05/ PY - 2009 DA - 2009 Nov 05 KW - Drugs KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42562272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+annual+European+Biomarkers+Summit&rft.atitle=Strategies+for+the+Co-Development+of+Drugs+and+Diagnostics+-+An+FDA+Perspective+on+Diagnostics+Regulation+in+Personalized+Medicine&rft.au=Kalush%2C+Francis&rft.aulast=Kalush&rft.aufirst=Francis&rft.date=2009-11-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+annual+European+Biomarkers+Summit&rft.issn=&rft_id=info:doi/ L2 - http://www.selectbiosciences.com/conferences/files/Agendas2009/AMP_EBS _PE_MSE.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three Federal Agencies Connecting the Dots On Dioxin in the Food Supply T2 - 65th Southwest Regional Meeting of the American Chemical Society AN - 42101504; 5534154 JF - 65th Southwest Regional Meeting of the American Chemical Society AU - Archer, Jeffrey AU - Dearfield, Kerry AU - Huwe, Janice AU - Lovell, Randall AU - Pagan-Rodriguez, Doritza AU - South, Paul AU - Schaum, John AU - Winters, Dwain AU - Young, Kim Y1 - 2009/11/04/ PY - 2009 DA - 2009 Nov 04 KW - Food supply KW - Dioxin KW - Food KW - Chlorinated hydrocarbons KW - Governments KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42101504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=65th+Southwest+Regional+Meeting+of+the+American+Chemical+Society&rft.atitle=Three+Federal+Agencies+Connecting+the+Dots+On+Dioxin+in+the+Food+Supply&rft.au=Archer%2C+Jeffrey%3BDearfield%2C+Kerry%3BHuwe%2C+Janice%3BLovell%2C+Randall%3BPagan-Rodriguez%2C+Doritza%3BSouth%2C+Paul%3BSchaum%2C+John%3BWinters%2C+Dwain%3BYoung%2C+Kim&rft.aulast=Archer&rft.aufirst=Jeffrey&rft.date=2009-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=65th+Southwest+Regional+Meeting+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://acs.confex.com/acs/swrm09/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Advanced Confocal Microscopy in Biophotonics and Nanobiophotonics T2 - Asia Communications and Photonics Conference and Exhibition (ACP 2009) AN - 42086117; 5524196 JF - Asia Communications and Photonics Conference and Exhibition (ACP 2009) AU - Ilev, Ilko AU - Chen, Yu Y1 - 2009/11/02/ PY - 2009 DA - 2009 Nov 02 KW - Confocal microscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42086117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Asia+Communications+and+Photonics+Conference+and+Exhibition+%28ACP+2009%29&rft.atitle=Advanced+Confocal+Microscopy+in+Biophotonics+and+Nanobiophotonics&rft.au=Ilev%2C+Ilko%3BChen%2C+Yu&rft.aulast=Ilev&rft.aufirst=Ilko&rft.date=2009-11-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Asia+Communications+and+Photonics+Conference+and+Exhibition+%28ACP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.acp-ce.cn/uploads/images/Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Defining critical inflammatory parameters for endotoxin impurity in manufactured alginate microcapsules AN - 883036008; 15243444 AB - Since current purification methods cannot completely remove all traces of endotoxin in biomaterials intended for use in implantable or blood-contacting devices, acceptable levels of endotoxin contamination that will not cause a significant inflammatory reaction need to be defined. Inflammatory reactions to biomaterials may include production of high concentrations of potentially harmful nitric oxide (NO) generated by macrophages. Nitrite accumulation was measured from RAW264.7 cells treated with either lipopolysaccharide (LPS) free in solution or defined quantities of LPS incorporated into alginate in the absence or presence of murine interferon- (mrIFN-). In the absence of IFN-, significant NO production by RAW 264.7 cells occurred for LPS levels down to 0.018 EU/mL. In the presence of mrIFN-, the lowest concentration of LPS tested in solution (0.006 EU/mL) elicited a significant increase in NO production. In the absence or presence of mrIFN-, five times the concentration of LPS incorporated into alginate as compared to LPS free in solution was necessary to elicit a similar NO response by RAW264.7. These results demonstrate that very low concentrations of endotoxin can elicit significant NO responses from macrophages, particularly when inflammatory cytokines are present. Biomaterials may sequester endotoxin, resulting in lower inflammatory reactions that otherwise might be expected. [copy 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009 JF - Journal of Biomedical Materials Research, Part B: Applied Biomaterials AU - Breger, Joyce C AU - Lyle, Daniel B AU - Shallcross, Jonathan C AU - Langone, John J AU - Wang, Nam Sun AD - Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, joyce.breger@fda.hhs.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 755 EP - 765 PB - Wiley-Blackwell VL - 91B IS - 2 SN - 1552-4981, 1552-4981 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Macrophages KW - Endotoxins KW - Contamination KW - Impurities KW - Inflammation KW - Interferon KW - Alginic acid KW - microcapsules KW - Biomaterials KW - Cytokines KW - Lipopolysaccharides KW - Nitric oxide KW - Purification KW - Nitrite KW - A 01310:Products of Microorganisms KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.atitle=Defining+critical+inflammatory+parameters+for+endotoxin+impurity+in+manufactured+alginate+microcapsules&rft.au=Breger%2C+Joyce+C%3BLyle%2C+Daniel+B%3BShallcross%2C+Jonathan+C%3BLangone%2C+John+J%3BWang%2C+Nam+Sun&rft.aulast=Breger&rft.aufirst=Joyce&rft.date=2009-11-01&rft.volume=91B&rft.issue=2&rft.spage=755&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.issn=15524981&rft_id=info:doi/10.1002%2Fjbm.b.31452 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31452/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Endotoxins; Macrophages; Contamination; Impurities; Inflammation; Interferon; Alginic acid; microcapsules; Biomaterials; Lipopolysaccharides; Cytokines; Nitric oxide; Purification; Nitrite DO - http://dx.doi.org/10.1002/jbm.b.31452 ER - TY - JOUR T1 - Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice AN - 883033553; 15241869 AB - In an effort to understand the disposition and toxicokinetics of nanoscale materials, we used EDS (energy dispersive X-ray spectroscopy) to detect and map the distribution of titanium dioxide (TiO2) in tissue sections from mice following either subcutaneous (s.c.) or intravenous (i.v.) injection. TiO2 nanoparticles were administered at a dose of 560 mg/kg (i.v.) or 5600 mg/kg (s.c.) to Balb/c female mice on two consecutive days. Tissues (liver, kidney, lung, heart, spleen, and brain) were examined by light microscopy, TEM (transmission electron microscopy), SEM (scanning electron microscopy), and EDS following necropsy one day after treatment. Particle agglomerates were detected by light microsopy in all tissues examined, EDS microanalysis was used to confirm that these tissues contained elemental titanium and oxygen. The TEM micrographs and EDS spectra of the aggregates were compared with in vitro measurements of TiO2 nanoparticle injection solution (i.e., in water). The nanoparticles were also characterized using dynamic light scattering in water, 10 mM NaCl, and phosphate buffered saline (PBS). In low ionic strength solvents (water and 10 mM NaCl), the TiO2 particles had average hydrodynamic diameters ranging from 114-122 nm. In PBS, however, the average diameter increases to 1-2 mu m, likely due to aggregation analogous to that observed in tissue by TEM and EDS. This investigation demonstrates the suitability of energy dispersive X-ray spectroscopy (EDS) for detection of nanoparticle aggregates in tissues and shows that disposition of TiO2 nanoparticles depends on the route of administration (i.v. or s.c.). Published in 2009 by John Wiley and Sons, Ltd. JF - Journal of Applied Toxicology AU - Patri, Anil AU - Umbreit, Thomas AU - Zheng, J AU - Nagashima, K AU - Goering, Peter AU - Francke-Carroll, Sabine AU - Gordon, Edward AU - Weaver, James AU - Miller, Terry AU - Sadrieh, Nakissa AU - McNeil, Scott AU - Stratmeyer, Mel AD - Nanotechnology Characterization Laboratory, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland 21702, USA, thomas.umbreit@fda.hhs.gov thomas.umbreit@fda.hhs.gov thomas.umbreit@fda.hhs.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 662 EP - 672 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 8 SN - 1099-1263, 1099-1263 KW - Environment Abstracts; Toxicology Abstracts KW - Autopsy KW - Hydrodynamics KW - titanium dioxide KW - Transmission electron microscopy KW - Light scattering KW - Particulates KW - Spectroscopy KW - Titanium dioxide KW - Sodium chloride KW - Heart KW - Titanium KW - Intravenous administration KW - Brain KW - Solvents KW - Spleen KW - Mice KW - Disposition KW - Phosphates KW - Phosphate KW - Lung KW - Ionizing radiation KW - Energy KW - Microscopy KW - X-ray spectroscopy KW - Kidney KW - nanoparticles KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883033553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Energy+dispersive+X-ray+analysis+of+titanium+dioxide+nanoparticle+distribution+after+intravenous+and+subcutaneous+injection+in+mice&rft.au=Patri%2C+Anil%3BUmbreit%2C+Thomas%3BZheng%2C+J%3BNagashima%2C+K%3BGoering%2C+Peter%3BFrancke-Carroll%2C+Sabine%3BGordon%2C+Edward%3BWeaver%2C+James%3BMiller%2C+Terry%3BSadrieh%2C+Nakissa%3BMcNeil%2C+Scott%3BStratmeyer%2C+Mel&rft.aulast=Patri&rft.aufirst=Anil&rft.date=2009-11-01&rft.volume=29&rft.issue=8&rft.spage=662&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=10991263&rft_id=info:doi/10.1002%2Fjat.1454 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jat.1454/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Heart; Autopsy; Intravenous administration; Titanium; Hydrodynamics; Transmission electron microscopy; Light scattering; Solvents; Spleen; Disposition; Spectroscopy; Titanium dioxide; Phosphate; Lung; Energy; Ionizing radiation; Kidney; nanoparticles; Sodium chloride; Phosphates; titanium dioxide; Microscopy; Brain; X-ray spectroscopy; Mice; Particulates DO - http://dx.doi.org/10.1002/jat.1454 ER - TY - JOUR T1 - A pilot respiratory health assessment of nail technicians: Symptoms, lung function, and airway inflammation AN - 745630960; 12739863 AB - Background Recent surveys suggest nail technicians, particularly artificial nail applicators, have increased respiratory symptoms and asthma risk. Methods We examined lung function (n = 62) and a marker of airway inflammation, i.e., exhaled nitric oxide (ENO) (n = 43), in a subset of nail technician and control participants in a pilot health assessment. Results Bivariate analysis of technicians demonstrated that job latency was inversely correlated with FEV1 percent predicted (FEV1PP) (r = -0.34, P = 0.03) and FVCPP (r = -0.32, P = 0.05). Acrylic gel contact hours were inversely correlated with FEV1PP (r = -0.38, P = 0.02) and FVCPP (r = -0.47, P = 0.003). Current smoking was inversely and significantly (P 0.05) associated with ENO in bivariate analysis. Log 10 ENO levels were directly correlated with job latency (P = 0.012) and gel nail application (P = 0.026) in multivariable analyses. Conclusions These positive pilot respiratory test results warrant additional future investigation. Am. J. Ind. Med. 52:868-875, 2009. JF - American Journal of Industrial Medicine AU - Reutman, Susan R AU - Rohs, Amy M AU - Clark, John C AU - Johnson, Belinda C AU - Sammons, Deborah L AU - Toennis, Christine A AU - Robertson, Shirley A AU - MacKenzie, Barbara A AU - Lockey, James E AD - Biomonitoring and Health Assessment Branch (BHAB), Division of Applied Research and Technology (DART), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, swr0@cdc.gov Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 868 EP - 875 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 52 IS - 11 SN - 0271-3586, 0271-3586 KW - nail technicians KW - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Asthma KW - Respiratory diseases KW - Nitric oxide KW - Respiratory function KW - technicians KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745630960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=A+pilot+respiratory+health+assessment+of+nail+technicians%3A+Symptoms%2C+lung+function%2C+and+airway+inflammation&rft.au=Reutman%2C+Susan+R%3BRohs%2C+Amy+M%3BClark%2C+John+C%3BJohnson%2C+Belinda+C%3BSammons%2C+Deborah+L%3BToennis%2C+Christine+A%3BRobertson%2C+Shirley+A%3BMacKenzie%2C+Barbara+A%3BLockey%2C+James+E&rft.aulast=Reutman&rft.aufirst=Susan&rft.date=2009-11-01&rft.volume=52&rft.issue=11&rft.spage=868&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20751 L2 - http://www3.interscience.wiley.com/journal/122596692/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Asthma; Nitric oxide; Respiratory diseases; Respiratory function; technicians; Occupational exposure DO - http://dx.doi.org/10.1002/ajim.20751 ER - TY - JOUR T1 - Educational Preferences and Outcomes From Suicide Prevention Training in the Veterans Health Administration: One-Year Follow-Up With Healthcare Employees in Upstate New York AN - 744715603; 13156158 AB - ABSTRACT This study identifies training outcomes and educational preferences of employees who work within the Veterans Health Administration (VHA). Using a longitudinal pre- postsurvey design, 71 employees from one geographic region of VHA healthcare facilities participated in an evaluation of a brief standardized gatekeeper program and a needs assessment on training preferences for suicide and suicide prevention. Results indicate significant differences in knowledge and self-efficacy from pre to post (p < 0.001), although only self-efficacy remained significant at 1 year follow-up, (M = 3.01; SD = 0.87) as compared to pretraining (M = 2.50, SD = 1.05) (t = -5.64, p < 0.001). At post-training, 90% of the participants were willing to learn more about suicide, with 88% willing to spend more than 1 hour in future training activities on more advanced topics. This training program can increase the knowledge and abilities of VHA staff to engage, identify, and refer veterans at risk for suicide to appropriate care. JF - Military Medicine AU - Matthieu, Monica M AU - Chen, Yufei AU - Schohn, Mary AU - Lantinga, Larry J AU - Knox, Kerry L AD - Washington University in St. Louis, George Warren Brown School of Social Work, Center for Mental Health Services Research, One Brookings Drive, Campus Box 1196, St. Louis, MO 63130. Y1 - 2009/11// PY - 2009 DA - Nov 2009 SP - 1123 EP - 1131 PB - Association of Military Surgeons of the US, 9320 Old Georgetown Road Bethesda, MD 20814 USA VL - 174 IS - 11 SN - 0026-4075, 0026-4075 KW - Risk Abstracts KW - Training KW - USA, New York KW - Health care KW - prevention KW - Standards KW - Military KW - suicide KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744715603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Medicine&rft.atitle=Educational+Preferences+and+Outcomes+From+Suicide+Prevention+Training+in+the+Veterans+Health+Administration%3A+One-Year+Follow-Up+With+Healthcare+Employees+in+Upstate+New+York&rft.au=Matthieu%2C+Monica+M%3BChen%2C+Yufei%3BSchohn%2C+Mary%3BLantinga%2C+Larry+J%3BKnox%2C+Kerry+L&rft.aulast=Matthieu&rft.aufirst=Monica&rft.date=2009-11-01&rft.volume=174&rft.issue=11&rft.spage=1123&rft.isbn=&rft.btitle=&rft.title=Military+Medicine&rft.issn=00264075&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/amsus/zmm/2009/00000174/00000011/art00014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Health care; Training; prevention; Standards; Military; suicide; USA, New York ER - TY - JOUR T1 - Rapid and chemically selective nicotine quantification in smokeless tobacco products using GC-MS. AN - 734152956; 19930803 AB - In recent years, there has been a rapid proliferation of smokeless products with a wide range of nicotine content and flavoring formulations that may appeal to new users and existing cigarette smokers. The CDC nicotine method, which employs gas chromatography-flame ionization detection (GC-FID), provides a robust means for measuring nicotine in smokeless tobacco. However, several compounds, identified in a few flavored smokeless products, interfere with nicotine quantification using GC-FID. In response, the standard nicotine method (26.7 min run time) was modified to use faster GC ramping (3.7 min run time) and detection with mass spectrometry (GC-MS) in selected ion-monitoring mode to reduce signal interferences that can bias nicotine values. Seven conventional smokeless samples (n = 12) and blank tobacco samples spiked at three nicotine concentration levels (n = 5) were analyzed using the GC-FID and GC-MS methods and found to be in excellent agreement. However, only the GC-MS method provided confirmation of chromatographic peak purity in certain highly flavored products. The GC-MS method is not intended to replace the GC-FID method but to provide a method versatile enough to analyze a wide range of nicotine values in domestic and international samples of varying complexity. Accurate nicotine quantification is important for determining total nicotine content in tobacco and in subsequent calculations of un-protonated nicotine content. JF - Journal of chromatographic science AU - Stanfill, Stephen B AU - Jia, Lily T AU - Ashley, David J AU - Watson, Clifford H AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Emergency Response and Air Toxicants Branch, Atlanta, Georgia 30341-3719, USA. PY - 2009 SP - 902 EP - 909 VL - 47 IS - 10 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Gas Chromatography-Mass Spectrometry -- methods KW - Nicotine -- analysis KW - Tobacco, Smokeless -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734152956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatographic+science&rft.atitle=Rapid+and+chemically+selective+nicotine+quantification+in+smokeless+tobacco+products+using+GC-MS.&rft.au=Stanfill%2C+Stephen+B%3BJia%2C+Lily+T%3BAshley%2C+David+J%3BWatson%2C+Clifford+H&rft.aulast=Stanfill&rft.aufirst=Stephen&rft.date=2009-11-01&rft.volume=47&rft.issue=10&rft.spage=902&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatographic+science&rft.issn=1945-239X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-17 N1 - Date created - 2009-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry. AN - 734143988; 19916526 AB - The aromatic nitroketone 3-nitrobenzanthrone (3-nitro-7H-benz[de]anthracen-7-one; 3-NBA) is an extremely potent mutagen and a suspected human carcinogen detected in the exhaust of diesel engines and in airborne particulate matter. 3-NBA is metabolically activated via reduction of the nitro group to the hydroxylamine (N-OH-3-ABA) to form covalent DNA adducts. Thus far, the detection and quantification of covalent 3-NBA-DNA adducts has relied solely on (32)P-postlabeling methodologies. In order to expand the range of available techniques for the detection and improved quantification of 3-NBA-DNA adducts, we have developed a method based upon online column-switching HPLC coupled to electrospray tandem mass spectrometry, with isotopic dilution of (15)N-labeled internal standards. This methodology was applied to the determination of three 3-NBA-derived adducts: 2-(2'-deoxyguanosin-N(2)-yl)-3-aminobenzanthrone (dG-N(2)-3-ABA), N-(2'-deoxyguanosin-8-yl)-3-aminobenzanthrone (dG-C8-N-3-ABA) and 2-(2'-deoxyguanosine-8-yl)-3-aminobenzanthrone (dG-C8-C2-3-ABA). Dose-dependent increases were observed for all three adducts when salmon testis DNA was reacted with N-acetoxy-3-aminobenzanthrone (N-AcO-3-ABA). dG-C8-C2-3-ABA was detected at much lower levels (overall 1%) than the other two adducts. DNA samples isolated from tissues of rats treated either intratracheally with 3-NBA or intraperitoneally with N-OH-3-ABA were analyzed by mass spectrometry, and the results compared to those obtained by (32)P-postlabeling. The method required 50 microg of hydrolyzed animal DNA on column and the limit of detection was 2.0 fmol for each adduct. dG-C8-C2-3-ABA was not observed in any of the samples providing confirmation that it is not formed in vivo. Linear regression analysis of the levels of dG-N(2)-3-ABA and dG-C8-N-3-ABA in the rat DNA showed a reasonable correlation between the two methods (R(2) = 0.88 and 0.93, respectively). In summary, the mass spectrometric method is a faster, more automated analytical approach that also provides structural confirmation of the adducts detected by (32)P-postlabeling, and it has sufficient sensitivity and precision to analyze DNA adducts in animals exposed to 3-NBA or its hydroxylamine metabolite. JF - Chemical research in toxicology AU - Gamboa da Costa, Gonçalo AU - Singh, Rajinder AU - Arlt, Volker M AU - Mirza, Amin AU - Richards, Meirion AU - Takamura-Enya, Takeji AU - Schmeiser, Heinz H AU - Farmer, Peter B AU - Phillips, David H AD - Institute of Cancer Research, Section of Molecular Carcinogenesis, Sutton, Surrey SM2 5NG, U.K. goncalo.gamboa@fda.hhs.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1860 EP - 1868 VL - 22 IS - 11 KW - 3-nitrobenzanthrone KW - 0 KW - Benz(a)Anthracenes KW - Carcinogens KW - DNA Adducts KW - Vehicle Emissions KW - Hydroxylamine KW - 2FP81O2L9Z KW - Index Medicus KW - Salmon KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Rats, Wistar KW - Tandem Mass Spectrometry KW - Hydroxylamine -- chemistry KW - Female KW - DNA Adducts -- analysis KW - Carcinogens -- chemistry KW - Chromatography, High Pressure Liquid -- methods KW - Benz(a)Anthracenes -- chemistry KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734143988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Quantification+of+3-nitrobenzanthrone-DNA+adducts+using+online+column-switching+HPLC-electrospray+tandem+mass+spectrometry.&rft.au=Gamboa+da+Costa%2C+Gon%C3%A7alo%3BSingh%2C+Rajinder%3BArlt%2C+Volker+M%3BMirza%2C+Amin%3BRichards%2C+Meirion%3BTakamura-Enya%2C+Takeji%3BSchmeiser%2C+Heinz+H%3BFarmer%2C+Peter+B%3BPhillips%2C+David+H&rft.aulast=Gamboa+da+Costa&rft.aufirst=Gon%C3%A7alo&rft.date=2009-11-01&rft.volume=22&rft.issue=11&rft.spage=1860&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx900264v LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-22 N1 - Date created - 2009-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx900264v ER - TY - JOUR T1 - Height, body mass index, and physical activity in relation to glioma risk. AN - 734114065; 19808953 AB - Whether energy balance during early life and/or adulthood is related to glioma risk is unknown. We therefore investigated height, body mass index (BMI), and physical activity in relation to glioma risk in the prospective NIH-AARP Diet and Health Study. Participants completed a baseline questionnaire (sent in 1995-1996) inquiring about height, weight, and potential confounders. A second questionnaire (sent in 1996) inquired about physical activity during ages 15 to 18, 19 to 29, and 35 to 39 years and the past 10 years and body weight at ages 18, 35, and 50 years. During follow-up from 1995/1996 to 2003, we documented 480 cases of glioma among 499,437 respondents to the baseline questionnaire and 257 cases among 305,681 respondents to the second questionnaire. Glioma risk among tall persons (>or=1.90 m) was twice that of short persons [<1.60 m; multivariate relative risk (RR), 2.12; 95% confidence interval (95% CI), 1.18-3.81; P(trend) = 0.006]. Risk among participants who were obese (BMI 30.0-34.9 kg/m(2)) at age 18 years was nearly four times that of persons of normal weight (BMI 18.5-24.9 kg/m(2)) at age 18 years (RR, 3.74; 95% CI, 2.03-6.90; P(trend) = 0.003); 11 cases were obese at age 18 years. Risk among participants who were active during ages 15 to 18 years was 36% lower than that of persons who were inactive during ages 15 to 18 years (RR, 0.64; 95% CI, 0.44-0.93; P(trend) = 0.02). BMI and physical activity after age 18 years were unrelated to glioma risk. Adult height, BMI during adolescence, and physical activity during adolescence were each associated with glioma risk, supporting a role for early-life energy balance in glioma carcinogenesis. JF - Cancer research AU - Moore, Steven C AU - Rajaraman, Preetha AU - Dubrow, Robert AU - Darefsky, Amy S AU - Koebnick, Corinna AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - Nutritional Epidemiology Branch and Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Rockville, Maryland, USA. moorest@mail.nih.gov Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 SP - 8349 EP - 8355 VL - 69 IS - 21 KW - Index Medicus KW - Young Adult KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Waist Circumference KW - Adolescent KW - Male KW - Brain Neoplasms -- epidemiology KW - Body Height KW - Glioma -- epidemiology KW - Exercise KW - Body Mass Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734114065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Height%2C+body+mass+index%2C+and+physical+activity+in+relation+to+glioma+risk.&rft.au=Moore%2C+Steven+C%3BRajaraman%2C+Preetha%3BDubrow%2C+Robert%3BDarefsky%2C+Amy+S%3BKoebnick%2C+Corinna%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BLeitzmann%2C+Michael+F&rft.aulast=Moore&rft.aufirst=Steven&rft.date=2009-11-01&rft.volume=69&rft.issue=21&rft.spage=8349&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-1669 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-23 N1 - Date created - 2009-10-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] PLoS Genet. 2006 Mar;2(3):e41 [16565746] Ann Epidemiol. 2008 Sep;18(9):682-95 [18794009] Ann Intern Med. 2008 Oct 7;149(7):461-71, W83-8 [18838726] Nat Genet. 2009 Jan;41(1):25-34 [19079261] Econ Hum Biol. 2009 Mar;7(1):109-12 [19195938] Endocr Rev. 2001 Feb;22(1):53-74 [11159816] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Epidemiol Rev. 2001;23(2):313-42 [12192740] Cancer Epidemiol Biomarkers Prev. 2003 Mar;12(3):223-5 [12646512] Horm Metab Res. 2003 Nov-Dec;35(11-12):694-704 [14710348] Am J Clin Nutr. 2004 Jul;80(1):185-92 [15213047] Neurology. 2004 Jul 27;63(2):276-81 [15277620] Neuroepidemiology. 1989;8(6):277-82 [2586697] Cancer Causes Control. 1992 Jul;3(4):349-54 [1617122] N Engl J Med. 1992 Nov 5;327(19):1350-5 [1406836] Epidemiology. 1995 Jan;6(1):61-6 [7888448] World Health Organ Tech Rep Ser. 1995;854:1-452 [8594834] Epidemiol Rev. 1995;17(2):382-414 [8654518] Diabetologia. 1997 Jul;40 Suppl 2:S25-31 [9248698] Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):863-73 [9367058] Med Sci Sports Exerc. 2004 Dec;36(12):2082-7 [15570143] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Am J Epidemiol. 2005 Aug 1;162(3):267-78 [15987729] J Clin Oncol. 2005 Jul 20;23(21):4742-54 [16034050] Endocr Rev. 2005 Dec;26(7):916-43 [16131630] Br J Cancer. 2008 Jul 8;99(1):185-90 [18560401] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-09-1669 ER - TY - JOUR T1 - Changes in asthma-like responses after extended removal from exposure to trimellitic anhydride in the Brown Norway rat model. AN - 734103207; 19549025 AB - Organic acid anhydride-induced occupational asthma is considered to be IgE-mediated. Airway and skin exposure are the two main routes of sensitization in the work place. Recently we developed an allergic asthmatic Brown Norway rat model sensitized by dermal exposure to trimellitic anhydride (TMA) using an occlusion patch application. The objectives of this study were (1) to develop a model of non-occluded dermal exposure leading to allergic sensitization and (2) to examine the effect of extended removal from exposure on persistence of both specific IgE and TMA aerosol-induced airway responses in this model. TMA powder (4 or 40 mg) was applied, unoccluded, to the skin of rats for 4 h, once/week for 4 weeks. Rats were given a 10-min aerosol challenge to 40 mg/m(3) TMA 2 weeks after the last dermal exposure (day 35). Another group was challenged on day 35 and again 18-24 months later. Respiratory enhanced pause (Penh), pulmonary histopathology and inflammation and specific IgE titres were measured. Rats produced dose-dependent specific IgE titres after exposure and developed early-phase (EAR) and late-phase airway responses (LAR) after airway challenge to TMA aerosol as well as airway eosinophilic inflammation. Specific airway responses were still manifested after a second TMA airway challenge given 18-24 months following the initial airway challenge. While persistent, airway inflammation, specific IgE and EAR were significantly attenuated following the second TMA challenge. LAR remained robust at 18-24 months and was not significantly different from the response on day 35. These results demonstrate the persistence of chemical sensitization and further suggest that IgE is not essential for LAR. JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology AU - Zhang, X D AU - Hubbs, A F AU - Siegel, P D AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1746 EP - 1753 VL - 39 IS - 11 KW - Aerosols KW - 0 KW - Allergens KW - Phthalic Anhydrides KW - Immunoglobulin E KW - 37341-29-0 KW - trimellitic anhydride KW - 80T61EUU7H KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Eosinophils -- pathology KW - Inflammation -- chemically induced KW - Occupational Exposure -- adverse effects KW - Disease Models, Animal KW - Inflammation -- immunology KW - Time Factors KW - Female KW - Inflammation -- pathology KW - Eosinophils -- immunology KW - Phthalic Anhydrides -- toxicity KW - Immunoglobulin E -- immunology KW - Allergens -- toxicity KW - Asthma -- chemically induced KW - Asthma -- pathology KW - Asthma -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734103207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+experimental+allergy+%3A+journal+of+the+British+Society+for+Allergy+and+Clinical+Immunology&rft.atitle=Changes+in+asthma-like+responses+after+extended+removal+from+exposure+to+trimellitic+anhydride+in+the+Brown+Norway+rat+model.&rft.au=Zhang%2C+X+D%3BHubbs%2C+A+F%3BSiegel%2C+P+D&rft.aulast=Zhang&rft.aufirst=X&rft.date=2009-11-01&rft.volume=39&rft.issue=11&rft.spage=1746&rft.isbn=&rft.btitle=&rft.title=Clinical+and+experimental+allergy+%3A+journal+of+the+British+Society+for+Allergy+and+Clinical+Immunology&rft.issn=1365-2222&rft_id=info:doi/10.1111%2Fj.1365-2222.2009.03304.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-15 N1 - Date created - 2009-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2222.2009.03304.x ER - TY - JOUR T1 - Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey. AN - 734086726; 19686844 AB - The relationship between the blood lead concentration and cognitive function in children and adults with different ALAD genotypes who participated in the third National Health and Nutrition Examination Survey was investigated. The relationship between blood lead and serum homocysteine concentrations was also investigated. In children 12 to 16 years old, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. In adults 20 to 59 years old, mean reaction time decreased as the blood lead concentration increased in the ALAD rs1800435 CC/CG group. This represents an improvement in performance. In adults 60 years and older, no difference in the relationship between cognitive function and blood lead concentration between genotypes was found. The serum homocysteine concentration increased as the blood lead concentration increased in adults 20 to 59 years old and 60 years and older, but there were no differences between genotypes. The mean blood lead concentration of children with the ALAD rs1800435 CC/CG genotype was less than that of children with the GG genotype. JF - Neurotoxicology and teratology AU - Krieg, Edward F AU - Butler, Mary Ann AU - Chang, Man-huei AU - Liu, Tiebin AU - Yesupriya, Ajay AU - Lindegren, Mary Lou AU - Dowling, Nicole AU - CDC/NCI NHANES III Genomics Working Group AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, Cincinnati, Ohio 45226, USA. erk3@cdc.gov ; CDC/NCI NHANES III Genomics Working Group PY - 2009 SP - 364 EP - 371 VL - 31 IS - 6 KW - Environmental Pollutants KW - 0 KW - Homocysteine KW - 0LVT1QZ0BA KW - Lead KW - 2P299V784P KW - Porphobilinogen Synthase KW - EC 4.2.1.24 KW - Index Medicus KW - Homocysteine -- blood KW - Polymorphism, Single Nucleotide KW - Age Factors KW - Humans KW - Aged KW - Child KW - Genotype KW - Psychomotor Performance -- drug effects KW - Aged, 80 and over KW - Adult KW - Environmental Exposure KW - Middle Aged KW - Mental Recall -- drug effects KW - Adolescent KW - Male KW - Female KW - Lead Poisoning -- blood KW - Cognition -- drug effects KW - Lead -- toxicity KW - Lead Poisoning -- genetics KW - Lead Poisoning -- psychology KW - Nutrition Surveys KW - Porphobilinogen Synthase -- genetics KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734086726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=That+Horse+Bit+Me%3A+Zoonotic+Infections+of+Equines+to+Consider+after+Exposure+Through+the+Bite+or+the+Oral%2FNasal+Secretions&rft.au=Langley%2C+R%3BMorris%2C+T&rft.aulast=Langley&rft.aufirst=R&rft.date=2009-01-01&rft.volume=14&rft.issue=3&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F10599240903058087 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-07 N1 - Date created - 2009-10-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ntt.2009.08.003 ER - TY - JOUR T1 - Development of a LC/MS/MS method to analyze butyrylcholinesterase inhibition resulting from multiple pesticide exposure. AN - 734081291; 19783488 AB - A hybrid LC/MS/MS and proteomics method was developed for the assessment of multiple pesticide exposure. The methodology was based on the analysis of tryptic peptides resulting from inhibited butyrylcholinesterase (BChE) after exposure to pesticides including organophosphates (OPs) and carbamates (CBs). The primary advantage of the assay was its ability to simultaneously examine multiple pesticide exposures in a single analytical experiment. Application of tandem and MS(3) techniques provided identities of the inhibiting pesticide, confirmation and localization of the site of inhibition and relative quantification of phosphorylated peptides present in tryptic digests of equine BChE (eBChE). JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Sun, Jinchun AU - Lynn, Bert C AD - Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, United States. Y1 - 2009/11/01/ PY - 2009 DA - 2009 Nov 01 SP - 3681 EP - 3685 VL - 877 IS - 29 KW - Carbamates KW - 0 KW - Organophosphates KW - Pesticides KW - Butyrylcholinesterase KW - EC 3.1.1.- KW - Index Medicus KW - Animals KW - Humans KW - Enzyme Activation -- drug effects KW - Horses KW - Carbamates -- adverse effects KW - Organophosphates -- adverse effects KW - Chromatography, Liquid -- methods KW - Tandem Mass Spectrometry -- methods KW - Pesticides -- adverse effects KW - Butyrylcholinesterase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734081291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Development+of+a+LC%2FMS%2FMS+method+to+analyze+butyrylcholinesterase+inhibition+resulting+from+multiple+pesticide+exposure.&rft.au=Sun%2C+Jinchun%3BLynn%2C+Bert+C&rft.aulast=Sun&rft.aufirst=Jinchun&rft.date=2009-11-01&rft.volume=877&rft.issue=29&rft.spage=3681&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=1873-376X&rft_id=info:doi/10.1016%2Fj.jchromb.2009.09.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-22 N1 - Date created - 2009-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jchromb.2009.09.009 ER - TY - JOUR T1 - Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain. AN - 734064533; 19580862 AB - Ketamine, a widely used pediatric anesthetic, has been associated with enhanced neuronal toxicity in the developing brain, but mechanisms and neuronal susceptibility to neurotoxic insult leading to neuronal cell death remain poorly defined. One of the main goals of this study was to determine whether there is a duration of ketamine-induced anesthesia below which no significant ketamine-induced neurodegeneration can be detected. Newborn rhesus monkeys (postnatal day 5 or 6) were administered ketamine intravenously for 3, 9 or 24h to maintain a steady anesthetic plane, followed by a 6-h withdrawal period. The 9- and 24-h durations were selected as relatively long and extremely long exposures, respectively, while the 3-h treatment more closely approximates a typical duration of pediatric general anesthesia. Animals were subsequently perfused under anesthesia and brain tissue was processed for analyses using silver and Fluoro-Jade C stains and caspase-3 immunostain. The results indicated that no significant neurotoxic effects occurred if the anesthesia duration was 3h. However, ketamine infusions for either 9 or 24h significantly increased neuronal cell death in layers II and III of the frontal cortex. Although a few caspase-3- and Fluoro-Jade C-positive neuronal profiles were observed in some additional brain areas including the hippocampus, thalamus, striatum and amygdala, no significant differences were detected between ketamine-treated and control monkeys in these areas after 3, 9 or 24h of exposure. These data show that treatment with ketamine up to 3h is without adverse effects as determined by nerve cell death. However, anesthetic durations of 9h or greater are associated with significant brain cell death in the frontal cortex. Thus, the threshold duration below which no neurotoxicity would be expected is somewhere between 3 and 9h. JF - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience AU - Zou, Xiaoju AU - Patterson, Tucker A AU - Divine, Rebecca L AU - Sadovova, Natalya AU - Zhang, Xuan AU - Hanig, Joseph P AU - Paule, Merle G AU - Slikker, William AU - Wang, Cheng AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 727 EP - 731 VL - 27 IS - 7 KW - Anesthetics, Dissociative KW - 0 KW - Fluoresceins KW - Organic Chemicals KW - fluoro jade KW - Ketamine KW - 690G0D6V8H KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Animals KW - Neurons -- metabolism KW - Organic Chemicals -- metabolism KW - Humans KW - Neurons -- cytology KW - Cell Death -- drug effects KW - Neurons -- pathology KW - Caspase 3 -- metabolism KW - Ketamine -- adverse effects KW - Macaca mulatta -- anatomy & histology KW - Anesthetics, Dissociative -- adverse effects KW - Brain -- pathology KW - Brain -- drug effects KW - Nerve Degeneration -- pathology KW - Nerve Degeneration -- chemically induced KW - Macaca mulatta -- physiology KW - Brain -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734064533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+developmental+neuroscience+%3A+the+official+journal+of+the+International+Society+for+Developmental+Neuroscience&rft.atitle=Prolonged+exposure+to+ketamine+increases+neurodegeneration+in+the+developing+monkey+brain.&rft.au=Zou%2C+Xiaoju%3BPatterson%2C+Tucker+A%3BDivine%2C+Rebecca+L%3BSadovova%2C+Natalya%3BZhang%2C+Xuan%3BHanig%2C+Joseph+P%3BPaule%2C+Merle+G%3BSlikker%2C+William%3BWang%2C+Cheng&rft.aulast=Zou&rft.aufirst=Xiaoju&rft.date=2009-11-01&rft.volume=27&rft.issue=7&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=International+journal+of+developmental+neuroscience+%3A+the+official+journal+of+the+International+Society+for+Developmental+Neuroscience&rft.issn=1873-474X&rft_id=info:doi/10.1016%2Fj.ijdevneu.2009.06.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-01 N1 - Date created - 2009-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijdevneu.2009.06.010 ER - TY - JOUR T1 - The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signaling. AN - 733812008; 20049119 AB - Ethylene glycol monomethyl ether (EGME) exposure is associated with impaired reproductive function. The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression. Because estrogen signaling is necessary for normal reproductive function and modulates gene expression, the estrogen-signaling pathway is a likely target for MAA; however, little is known about the effects of MAA in this regard. We evaluated the mechanistic effects of MAA on estrogen receptor (ER) expression and estrogen signaling using in vitro and in vivo model systems. MAA potentiates 17beta-estradiol (E(2)) stimulation of an estrogen-responsive reporter plasmid in HeLa cells transiently transfected with either a human ERalpha or ERbeta expression vector containing a cytomegalovirus (CMV) promoter. This result is attributed to increased exogenous ER expression due to MAA-mediated activation of the CMV promoter. In contrast to its effects on exogenous ER, MAA decreases endogenous ERalpha expression and attenuates E(2)-stimulated endogenous gene expression in both MCF-7 cells and the mouse uterus. These results illustrate the importance of careful experimental design and analysis when assessing the potential endocrine-disrupting properties of a compound to ensure biological responses are in concordance with in vitro analyses. Given the established role of the ER in normal reproductive function, the effects of MAA on the endogenous ER reported here are consistent with the reproductive abnormalities observed after EGME exposure and suggest that these toxicities may be due, at least in part, to attenuation of endogenous ER-mediated signaling. JF - Environmental health perspectives AU - Henley, Derek V AU - Mueller, Stephanie AU - Korach, Kenneth S AD - Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 1702 EP - 1706 VL - 117 IS - 11 KW - Acetates KW - 0 KW - Endocrine Disruptors KW - Estrogen Receptor alpha KW - Estrogen Receptor beta KW - Estradiol KW - 4TI98Z838E KW - methoxyacetic acid KW - F11T1H7Q7W KW - Index Medicus KW - estrogen KW - short-chain fatty acid KW - estrogen receptor KW - Animals KW - HeLa Cells KW - Humans KW - Estradiol -- pharmacology KW - Cell Line, Tumor KW - Mice KW - Research Design KW - Uterus -- drug effects KW - Uterus -- metabolism KW - Endocrine Disruptors -- toxicity KW - Promoter Regions, Genetic KW - Signal Transduction -- drug effects KW - Cytomegalovirus -- genetics KW - Mice, Inbred C57BL KW - Female KW - Estrogen Receptor alpha -- genetics KW - Estrogen Receptor alpha -- drug effects KW - Gene Expression Regulation -- drug effects KW - Estrogen Receptor beta -- drug effects KW - Acetates -- toxicity KW - Estrogen Receptor beta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733812008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+short-chain+fatty+acid+methoxyacetic+acid+disrupts+endogenous+estrogen+receptor-alpha-mediated+signaling.&rft.au=Henley%2C+Derek+V%3BMueller%2C+Stephanie%3BKorach%2C+Kenneth+S&rft.aulast=Henley&rft.aufirst=Derek&rft.date=2009-11-01&rft.volume=117&rft.issue=11&rft.spage=1702&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0900800 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-26 N1 - Date created - 2010-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 1983 Nov 11;11(21):7631-48 [6316266] Toxicol Appl Pharmacol. 1983 Feb;67(2):229-37 [6836577] Environ Health Perspect. 1984 Aug;57:207-17 [6499806] Breast Cancer Res Treat. 1984;4(4):269-74 [6518293] Am J Ind Med. 1988;14(5):509-26 [3228067] N Engl J Med. 1993 Nov 4;329(19):1383-8 [8413434] Am J Epidemiol. 1996 Apr 1;143(7):707-17 [8651233] Biochem Biophys Res Commun. 1996 Jul 25;224(3):796-801 [8713125] Toxicol Appl Pharmacol. 1997 Feb;142(2):328-37 [9070356] Virology. 1997 May 12;231(2):201-9 [9168882] Brain Res Mol Brain Res. 1999 Jan 22;64(1):52-8 [9889318] Endocrinology. 2004 Dec;145(12):5485-92 [15345672] Toxicol Lett. 2005 Mar 28;156(1):13-28 [15705484] Annu Rev Physiol. 2005;67:285-308 [15709960] Mol Endocrinol. 2005 Apr;19(4):833-42 [15695368] Cancer Lett. 2005 Jul 28;225(2):199-206 [15978324] Oncogene. 2005 Jul 21;24(31):4894-907 [15870696] Cell Death Differ. 2006 Mar;13(3):446-53 [16167071] Epilepsy Behav. 2007 Feb;10(1):77-83 [17098479] Endocr Relat Cancer. 2007 Dec;14(4):1021-8 [18045953] Toxicol Appl Pharmacol. 2009 Jul 15;238(2):101-10 [18486176] Toxicol Appl Pharmacol. 2000 May 15;165(1):53-62 [10814553] J Biol Chem. 2001 Sep 28;276(39):36734-41 [11473107] EMBO J. 2001 Dec 17;20(24):6969-78 [11742974] J Clin Psychiatry. 2002 Apr;63(4):322-30 [12000206] Am J Hematol. 2002 Sep;71(1):45-6 [12221674] Mol Cell Endocrinol. 2004 Jan 15;213(2):173-9 [15062565] Proc Natl Acad Sci U S A. 2004 May 4;101(18):7199-204 [15103026] Steroids. 1971 Aug;18(2):219-29 [5126820] J Biol Chem. 1978 May 25;253(10):3364-6 [649576] Cell. 1978 May;14(1):115-21 [667928] Biochem Biophys Res Commun. 1984 Feb 29;119(1):132-8 [6704117] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0900800 ER - TY - JOUR T1 - Computational toxicology approaches at the US Food and Drug Administration. AN - 733806985; 20017581 AB - For over a decade, the United States Food and Drug Administration (US FDA) has been engaged in the applied research, development, and evaluation of computational toxicology methods used to support the safety evaluation of a diverse set of regulated products. The basis for evaluating computational toxicology methods is multi-factorial, including the potential for increased efficiency, reduction in the numbers of animals used, lower costs, and the need to explore emerging technologies that support the goals of the US FDA's Critical Path Initiative (e.g. to make decision support information available early in the drug review process). The US FDA's efforts have been facilitated by agency-approved data-sharing agreements between government and commercial software developers. This commentary review describes former and current scientific initiatives at the agency, in the area of computational toxicology methods. In particular, toxicology-based QSAR models, ToxML databases and knowledgebases will be addressed. Notably, many of the computational toxicology tools available are commercial products - however, several are emerging as non-commercial products, which are freely-available to the public, and which will facilitate the understanding of how these programs work and avoid the "black box" paradigm. Through productive collaborations, the US FDA Center for Drug Evaluation and Research, and the Center for Food Safety and Applied Nutrition, have worked together to evaluate, develop and apply these methods to chemical toxicity endpoints of regulatory interest. 2009 FRAME. JF - Alternatives to laboratory animals : ATLA AU - Yang, Chihae AU - Valerio, Luis G AU - Arvidson, Kirk B AD - Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA. chihae.yang@fda.hhs.gov Y1 - 2009/11// PY - 2009 DA - November 2009 SP - 523 EP - 531 VL - 37 IS - 5 SN - 0261-1929, 0261-1929 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Quantitative Structure-Activity Relationship KW - Pharmaceutical Preparations -- chemistry KW - Humans KW - Computational Biology -- methods KW - Databases, Factual KW - Toxicology -- methods KW - Knowledge Bases KW - Database Management Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733806985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alternatives+to+laboratory+animals+%3A+ATLA&rft.atitle=Computational+toxicology+approaches+at+the+US+Food+and+Drug+Administration.&rft.au=Yang%2C+Chihae%3BValerio%2C+Luis+G%3BArvidson%2C+Kirk+B&rft.aulast=Yang&rft.aufirst=Chihae&rft.date=2009-11-01&rft.volume=37&rft.issue=5&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Alternatives+to+laboratory+animals+%3A+ATLA&rft.issn=02611929&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-25 N1 - Date created - 2009-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks. AN - 733792849; 19778631 AB - Methylphenidate hydrochloride (MPH), a widely prescribed pediatric drug for attention deficit hyperactivity disorder, induced liver adenocarcinomas in B6C3F1 mice exposed to 500 ppm in feed for 2 years (Dunnick and Hailey (1995) [14]). In order to determine if the induction of liver tumors was by a mutagenic mode of action, groups of male Big Blue (BB) mice (B6C3F1 background) were fed diets containing 50-4000 ppm MPH for 4, 12, or 24 weeks. At sacrifice, the livers were removed and the cII mutant frequency (MF) and spectrum of cII mutations were determined. In addition, the frequencies of micronucleated reticulocytes (MN-RETs) and normochromatic erythrocytes (MN-NCEs) were measured in peripheral blood erythrocytes as was the Hprt MF in splenic lymphocytes. Food consumption and body weight gain/loss were recorded weekly for each animal. The levels of MPH and RA were determined immediately before sacrifice in the serum of mice fed MPH for 24 weeks. A significant loss in body weights (p or =10(2) cfu g(-1). Another 0.3% of salad samples were of unacceptable quality due to S. aureus at > or =10(4) cfu g(-1) (2 samples) or the presence of Salmonella Kentucky (1 sample). Cucumber was the most contaminated salad vegetable with regards to unsatisfactory levels of E. coli (6.0%) or S. aureus (4.5%). Five percent of 1208 sauce samples were of unsatisfactory microbiological quality due to E. coli, S. aureus at > or =10(2) cfu g(-1) and/or Bacillus cereus and other Bacillus spp. at > or =10(4) cfu g(-1). A further 0.6% of sauce samples were of unacceptable quality due to Bacillus spp. (Bacillus subtilis, Bacillus pumilus, Bacillus licheniformis) at > or =10(5) cfu g(-1) or the presence of Salmonella Agbeni (1 sample). More samples of chili sauce (8.7%) were of unsatisfactory or unacceptable microbiological quality than any other sauce types. The results emphasize the need for good hygiene practices in kebab take-away restaurants handling these types of ready-to-eat products. JF - Food microbiology AU - Meldrum, R J AU - Little, C L AU - Sagoo, S AU - Mithani, V AU - McLauchlin, J AU - de Pinna, E AD - National Public Health Service for Wales, Microbiology Laboratory, Llandough Hospital, Penarth, Vale of Glamorgan CF64 2XX, UK. Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 573 EP - 577 VL - 26 IS - 6 KW - Index Medicus KW - Escherichia coli -- isolation & purification KW - Staphylococcus aureus -- isolation & purification KW - Humans KW - Colony Count, Microbial KW - Salmonella -- isolation & purification KW - Bacillus -- isolation & purification KW - Hygiene KW - United Kingdom KW - Vegetables -- microbiology KW - Consumer Product Safety KW - Restaurants -- standards KW - Food Handling -- methods KW - Food Contamination -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67381038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+microbiology&rft.atitle=Assessment+of+the+microbiological+safety+of+salad+vegetables+and+sauces+from+kebab+take-away+restaurants+in+the+United+Kingdom.&rft.au=Meldrum%2C+R+J%3BLittle%2C+C+L%3BSagoo%2C+S%3BMithani%2C+V%3BMcLauchlin%2C+J%3Bde+Pinna%2C+E&rft.aulast=Meldrum&rft.aufirst=R&rft.date=2009-09-01&rft.volume=26&rft.issue=6&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Food+microbiology&rft.issn=1095-9998&rft_id=info:doi/10.1016%2Fj.fm.2009.03.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fm.2009.03.013 ER - TY - BOOK T1 - Results of In-Mine Research in Support of the Investigation of the Sago Mine Explosion AN - 58839800; 2008-442372 AB - The Mine Safety and Health Administration (MSHA) and the West Virginia Office of Miners Health, Safety, and Training (WVOMHS&T) investigated the explosion at the Sago Mine in West Virginia, which occurred on January 2, 2006, and resulted in 12 fatalities. As part of the investigation, the agencies requested that the National Institute for Occupational Safety and Health's (NIOSH) Pittsburgh Research Laboratory evaluate the effects of explosions on specific mine ventilation seals and other structures and objects at its Lake Lynn Experimental Mine (LLEM). Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Sep 2009, 148 pp. AU - Cashdollar, Kenneth L AU - Harteis, Samuel P AU - Sapko, Michael J AU - Urosek, John E AU - Weiss, Eric S Y1 - 2009/09// PY - 2009 DA - September 2009 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Mining and mineral resources KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Labor conditions and policy - Occupational health and safety KW - Administration of justice - Police and law enforcement KW - Manufacturing and heavy industry - Chemical industries KW - Military and defense policy - Military equipment and weapons KW - Investigation KW - Explosives KW - Mining industry KW - Industrial safety KW - Working conditions KW - West Virginia KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58839800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Cashdollar%2C+Kenneth+L%3BHarteis%2C+Samuel+P%3BSapko%2C+Michael+J%3BUrosek%2C+John+E%3BWeiss%2C+Eric+S&rft.aulast=Cashdollar&rft.aufirst=Kenneth&rft.date=2009-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Results+of+In-Mine+Research+in+Support+of+the+Investigation+of+the+Sago+Mine+Explosion&rft.title=Results+of+In-Mine+Research+in+Support+of+the+Investigation+of+the+Sago+Mine+Explosion&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2009-168.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-02-03 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2009 N1 - SuppNotes - NIOSH Publication No. 2009-168 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Income, Insurance, And Technology: Why Does Health Spending Outpace Economic Growth? AN - 58831623; 2008-410644 AB - A broad consensus holds that increased medical capability-technology-is the primary driver of health spending growth. However, technology does not expand independently of historical context; it is fueled by rising incomes and more generous insurance coverage. We estimate that medical technology explains 27-48 percent of health spending growth since 1960-a smaller percentage than earlier estimates. Income (gross domestic product, or GDP) growth plays a critical role, primarily through the actions of governments and employers on behalf of pools of consumers. The contribution of insurance is likely to differ, with less of a push from increasing generosity of coverage and more of a push from changes in provider payment. Adapted from the source document. JF - Health Affairs AU - Smith, Sheila AU - Newhouse, Joseph P AU - Freeland, Mark S AD - Office of the Actuary, Centers for Medicare and Medicaid Services, Baltimore, Maryland ssmith2@cms.hhs.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 1276 EP - 1284 PB - Project HOPE, Bethesda MD VL - 28 IS - 5 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Medicine and health care KW - Economic conditions and policy - Economic theory KW - Science and technology policy - Technology and technology policy KW - Cost KW - Quality control KW - Medical service KW - Medical technology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58831623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Income%2C+Insurance%2C+And+Technology%3A+Why+Does+Health+Spending+Outpace+Economic+Growth%3F&rft.au=Smith%2C+Sheila%3BNewhouse%2C+Joseph+P%3BFreeland%2C+Mark+S&rft.aulast=Smith&rft.aufirst=Sheila&rft.date=2009-09-01&rft.volume=28&rft.issue=5&rft.spage=1276&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.28.5.1276 LA - English DB - PAIS Index N1 - Date revised - 2009-11-02 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medical service; Cost; Medical technology; Quality control DO - http://dx.doi.org/10.1377/hlthaff.28.5.1276 ER - TY - JOUR T1 - e-Supplement: 'Learn the signs. Act early': A campaign to help every child reach his or her full potential AN - 57313555; 201000264 AB - Objective To examine the application of a social marketing approach to increase the early identification and treatment of autism and other developmental disorders. Study design The intervention used formative research, behaviour change theory and traditional social marketing techniques to develop a campaign targeting parents, healthcare professionals and early educators to increase awareness of autism and other developmental delays, and to prompt action if a developmental delay was suspected. Method Using social marketing principles, the Centers for Disease Control and Prevention applied baseline research with the target audiences to understand the barriers and motivators to behaviour change, which included a lack of knowledge and resources (barriers), along with a willingness to learn and do more (motivators). Focus group testing of potential campaign concepts led to one particular approach and accompanying images, which together increased perceived severity of the problem and encouraged taking action. The audience research also helped to shape the marketing mix (product, price, place and promotion). Results Three-year follow-up research in this case study indicates a significant change in parent target behaviours, particularly among parents aware of the campaign, and substantially more healthcare professionals believe that they have the resources to educate parents about monitoring their child's cognitive, social and physical development. Qualitative results from early educators and childcare professional associations have been positive about products developed for daycare settings. Conclusion The application of social marketing principles, behavior change theory and audience research was an effective approach to changing behaviours in this case. Understanding what the target audiences want and need, looking beyond parents to engage healthcare professionals and early educators, and engaging many strategic partners to extend the reach of the message helped campaign planners to develop a campaign that resonated with the target audiences and, importantly, moved them towards action. [Copyright Elsevier B.V.] JF - Public Health AU - Daniel, K L AU - Prue, C AU - Taylor, M K AU - Thomas, J AU - Scales, M AD - Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2009/09// PY - 2009 DA - September 2009 SP - e11 EP - e16 PB - Elsevier Ltd, The Netherlands VL - 123 SN - 0033-3506, 0033-3506 KW - Autism Social marketing Marketing mix Developmental screening Campaign Stages of change Transtheoretical model KW - Social marketing KW - Campaigns KW - Health professionals KW - Motivation KW - Behavioural changes KW - Parents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57313555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health&rft.atitle=e-Supplement%3A+%27Learn+the+signs.+Act+early%27%3A+A+campaign+to+help+every+child+reach+his+or+her+full+potential&rft.au=Daniel%2C+K+L%3BPrue%2C+C%3BTaylor%2C+M+K%3BThomas%2C+J%3BScales%2C+M&rft.aulast=Daniel&rft.aufirst=K&rft.date=2009-09-01&rft.volume=123&rft.issue=&rft.spage=e11&rft.isbn=&rft.btitle=&rft.title=Public+Health&rft.issn=00333506&rft_id=info:doi/10.1016%2Fj.puhe.2009.06.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-01-05 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Campaigns; Parents; Social marketing; Behavioural changes; Health professionals; Motivation DO - http://dx.doi.org/10.1016/j.puhe.2009.06.002 ER - TY - JOUR T1 - Application of direct push methods to investigate uranium distribution in an alluvial aquifer AN - 50089213; 2010-018035 AB - The U.S. EPA 2000 Radionuclide Rule established a maximum contaminant level (MCL) for uranium of 30 mu g/L. Many small community water supplies are struggling to comply with this new regulation. At one such community, direct push (DP) methods were applied to obtain hydraulic profiling tool (HPT) logs and install small diameter wells in a section of alluvial deposits located along the Platte River. This work was conducted to evaluate potential sources of elevated uranium in the Clarks, Nebraska drinking water supply. HPT logs were used to understand the hydrostratigraphy of a portion of the aquifer and guide placement of small diameter wells at selected depth intervals. Low-flow sampling of the wells provided water quality parameters and samples for analysis to study the distribution of uranium and variations in aquifer chemistry. Contrary to expectations, the aquifer chemistry revealed that uranium was being mobilized under anoxic and reducing conditions. Review of the test well and new public water supply well construction details revealed that filter packs extended significantly above the screened intervals of the wells. These filter packs were providing a conduit for the movement of groundwater with elevated concentrations of uranium into the supply wells and the community drinking water supply. The methods applied and lessons learned here may be useful for the assessment of unconsolidated aquifers for uranium, arsenic, and many other drinking water supply contaminants. Abstract Copyright (2009), National Ground Water Association. JF - Ground Water Monitoring & Remediation AU - McCall, Wesley AU - Christy, Thomas M AU - Christopherson, Thomas AU - Issacs, Howard Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 65 EP - 76 PB - Wiley-Blackwell on behalf of National Ground Water Association, Malden, MA VL - 29 IS - 4 SN - 1069-3629, 1069-3629 KW - United States KW - water quality KW - techniques KW - drinking water KW - ground water KW - electron probe data KW - spatial distribution KW - Platte River KW - sampling KW - concentration KW - water supply KW - toxic materials KW - well logs KW - arsenic KW - uranyl ion KW - pollution KW - aquifers KW - Merrick County Nebraska KW - detection KW - alluvium aquifers KW - metals KW - anaerobic environment KW - uranium KW - water wells KW - Nebraska KW - actinides KW - instruments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50089213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ground+Water+Monitoring+%26+Remediation&rft.atitle=Application+of+direct+push+methods+to+investigate+uranium+distribution+in+an+alluvial+aquifer&rft.au=McCall%2C+Wesley%3BChristy%2C+Thomas+M%3BChristopherson%2C+Thomas%3BIssacs%2C+Howard&rft.aulast=McCall&rft.aufirst=Wesley&rft.date=2009-09-01&rft.volume=29&rft.issue=4&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Ground+Water+Monitoring+%26+Remediation&rft.issn=10693629&rft_id=info:doi/10.1111%2Fj.1745-6592.2009.01258.x L2 - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1745-6592 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2010-01-01 N1 - Number of references - 23 N1 - PubXState - MA N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2016-10-25 N1 - SubjectsTermNotLitGenreText - actinides; alluvium aquifers; anaerobic environment; aquifers; arsenic; concentration; detection; drinking water; electron probe data; ground water; instruments; Merrick County Nebraska; metals; Nebraska; Platte River; pollution; sampling; spatial distribution; techniques; toxic materials; United States; uranium; uranyl ion; water quality; water supply; water wells; well logs DO - http://dx.doi.org/10.1111/j.1745-6592.2009.01258.x ER - TY - JOUR T1 - Comparative Evaluation of the Immune Responses and Protection Engendered by LC16m8 and Dryvax Smallpox Vaccines in a Mouse Model AN - 21481442; 12492687 AB - The immune response elicited by LC16m8, a candidate smallpox vaccine that was developed in Japan by cold selection during serial passage of the Lister vaccine virus in primary rabbit kidney cells, was compared to Dryvax in a mouse model. LC16m8 carries a mutation resulting in the truncation of the B5 protein, an important neutralizing target of the extracellular envelope form of vaccinia virus (EV). LC16m8 elicited a broad-spectrum immunoglobulin G (IgG) response that neutralized both EV and the intracellular mature form of vaccinia virus and provoked cell-mediated immune responses, including the activation of CD4+ and CD8+ cells, similarly to Dryvax. Mice inoculated with LC16m8 had detectable but low levels of anti-B5 IgG compared to Dryvax, but both Dryvax and LC16m8 sera neutralized vaccinia virus EV in vitro. A truncated B5 protein (8 kDa) was expressed abundantly in LC16m8-infected cells, and both murine immune sera and human vaccinia virus immunoglobulin recognized the truncated recombinant B5 protein in antigen-specific enzyme-linked immunosorbent assays. At a high-dose intranasal challenge (100 or 250 50% lethal doses), LC16m8 and Dryvax conferred similar levels of protection against vaccinia virus strain WR postvaccination. Taken together, the results extend our current understanding of the protective immune responses elicited by LC16m8 and indicate that the relative efficacy in a mouse model rivals that of previously licensed smallpox vaccines. JF - Clinical and Vaccine Immunology AU - Meseda, Clement A AU - Mayer, Anne E AU - Kumar, Arunima AU - Garcia, Alonzo D AU - Campbell, Joseph AU - Listrani, Paul AU - Manischewitz, Jody AU - King, Lisa R AU - Golding, Hana AU - Merchlinsky, Michael AU - Weir, Jerry P AD - Laboratory of DNA Viruses, Division of Viral Products, HFM-457, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852, clement.meseda@fda.hhs.gov clement.meseda@fda.hhs.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 1261 EP - 1271 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 16 IS - 9 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Animal models KW - CD4 antigen KW - CD8 antigen KW - Envelopes KW - Enzyme-linked immunosorbent assay KW - Immune response KW - Immune response (cell-mediated) KW - Immunoglobulin G KW - Kidney KW - Lethal dose KW - Mutation KW - Smallpox KW - Vaccines KW - Vaccinia virus KW - V 22300:Methods KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21481442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Comparative+Evaluation+of+the+Immune+Responses+and+Protection+Engendered+by+LC16m8+and+Dryvax+Smallpox+Vaccines+in+a+Mouse+Model&rft.au=Meseda%2C+Clement+A%3BMayer%2C+Anne+E%3BKumar%2C+Arunima%3BGarcia%2C+Alonzo+D%3BCampbell%2C+Joseph%3BListrani%2C+Paul%3BManischewitz%2C+Jody%3BKing%2C+Lisa+R%3BGolding%2C+Hana%3BMerchlinsky%2C+Michael%3BWeir%2C+Jerry+P&rft.aulast=Meseda&rft.aufirst=Clement&rft.date=2009-09-01&rft.volume=16&rft.issue=9&rft.spage=1261&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00040-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Animal models; CD8 antigen; Smallpox; CD4 antigen; Immune response (cell-mediated); Envelopes; Immunoglobulin G; Kidney; Vaccines; Immune response; Mutation; Lethal dose; Vaccinia virus DO - http://dx.doi.org/10.1128/CVI.00040-09 ER - TY - JOUR T1 - Workplace Exposures and the Risk of Amyotrophic Lateral Sclerosis AN - 21260503; 11702314 AB - Background Occupation has been suggested to play a role in amyotrophic lateral sclerosis (ALS) etiology, but detailed information on the importance of specific workplace exposures is lacking. Objectives Our aim was to assess the relationship between workplace exposures and the risk of ALS and to evaluate potential interactions between these exposures and smoking. Methods We conducted a caseacontrol study in New England between 1993 and 1996, comprising 109 cases and 253 controls who completed a structured interview covering occupations and workplace exposures. Unconditional logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for ALS. Analyses were conducted among the entire study population and after stratification by smoking. Results We observed a higher risk of ALS for construction workers excluding supervisors (OR = 2.9; 95% CI, 1.2a7.2) and precision metal workers (OR = 3.5; 95% CI, 1.2a10.5). Self-reported exposures to paint strippers; cutting, cooling, or lubricating oils; antifreeze or coolants; mineral or white spirits; and dry cleaning agents each appeared to be associated with a 60a90% higher risk. Specific chemicals related to a > 50% increase in risk of ALS included aliphatic chlorinated hydrocarbons, glycols, glycol ethers, and hexane. Relative risks associated with these workplace exposures and chemicals were greater among nonsmokers and persisted in mutually adjusted models. Conclusions Our data suggest that certain occupations and workplace exposures may be associated with increased risk of ALS. These results need to be confirmed in independent populations. JF - Environmental Health Perspectives AU - Fang, Fang AU - Quinlan, Patricia AU - Ye, Weimin AU - Barber, Marie K AU - Umbach, David M AU - Sandler, Dale P AU - Kamel, Freya AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 1387 EP - 1392 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 117 IS - 9 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Risk Abstracts; CSA Neurosciences Abstracts; Environment Abstracts KW - amyotrophic lateral sclerosis KW - chemicals KW - relative risk KW - risk factors KW - workplace exposures KW - Chemicals KW - Risk assessment KW - Stratification KW - cuttings KW - Models KW - Oil KW - Smoking KW - Workers KW - USA, New England KW - Risk factors KW - Regression analysis KW - Ethers KW - Construction industry KW - Metals KW - Etiology KW - Data processing KW - Glycol ethers KW - Oils KW - Population studies KW - Antifreezes KW - Chlorinated hydrocarbons KW - Amyotrophic lateral sclerosis KW - Minerals KW - n-Hexane KW - Paints KW - ENA 13:Population Planning & Control KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21260503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Workplace+Exposures+and+the+Risk+of+Amyotrophic+Lateral+Sclerosis&rft.au=Fang%2C+Fang%3BQuinlan%2C+Patricia%3BYe%2C+Weimin%3BBarber%2C+Marie+K%3BUmbach%2C+David+M%3BSandler%2C+Dale+P%3BKamel%2C+Freya&rft.aulast=Fang&rft.aufirst=Fang&rft.date=2009-09-01&rft.volume=117&rft.issue=9&rft.spage=1387&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0900580 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Metals; Etiology; Data processing; Glycol ethers; Oils; Population studies; Antifreezes; Chlorinated hydrocarbons; Models; Workers; Smoking; Amyotrophic lateral sclerosis; Risk factors; Regression analysis; Minerals; n-Hexane; Paints; Oil; Chemicals; Stratification; Ethers; cuttings; Construction industry; USA, New England DO - http://dx.doi.org/10.1289/ehp.0900580 ER - TY - JOUR T1 - Expanded range and new host species of Mycobacterium shottsii and M. pseudoshottsii AN - 21184850; 11586454 AB - Mycobacterium shottsii and M. pseudoshottsii are recently described mycobacteria commonly isolated from Chesapeake Bay striped bass Morone saxatilis. However, their distribution in striped bass outside of the Chesapeake region and their ability to infect alternative hosts have not been described. Mycobacteria identified as M. shottsii (based on fatty acid methyl ester analysis and multigene sequencing) were isolated from striped bass collected in Albemarle Sound, North Carolina, and white perch Morone americana in the Rhode River, Maryland, and detected in striped bass from the New York Bight off Long Island, New York. Mycobacterium pseudoshottsii were isolated from white perch in the Rhode and Corsica rivers, Maryland, and detected in striped bass in the New York Bight. This work demonstrates that these mycobacteria can be found outside of the Chesapeake Bay as well as in hosts other than striped bass. JF - Journal of Aquatic Animal Health AU - Stine, Cynthia B AU - Jacobs, John M AU - Rhodes, Matt R AU - Overton, Anthony AU - Fast, Mark AU - Baya, Ana M AD - University of Maryland, Virginia-Maryland College of Veterinary Medicine, College Park, Maryland, USA, cynthia.stine@fda.hhs.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 179 EP - 183 PB - American Fisheries Society, 5410 Grosvenor Ln. Bethesda MD 20814-2199 USA VL - 21 IS - 3 SN - 0899-7659, 0899-7659 KW - ASFA Aquaculture Abstracts; Microbiology Abstracts B: Bacteriology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA Marine Biotechnology Abstracts KW - Aquatic animals KW - Geographical distribution KW - USA, Maryland, Rhode R. KW - ANW, USA, North Carolina, Albemarle Sound KW - ANW, USA, New York, Long Island KW - Freshwater fish KW - Morone americana KW - Islands KW - Sound KW - fatty acid methyl esters KW - Mycobacterium shottsii KW - Diseases KW - Brackishwater fish KW - Rivers KW - ANW, USA, North Carolina KW - Brackish KW - ANW, USA, Chesapeake Bay KW - ANW, USA, New York Bight KW - ANW, USA, Maryland KW - Morone saxatilis KW - Fish diseases KW - Fatty acids KW - Taxonomy KW - New species KW - O 1070:Ecology/Community Studies KW - Q4 27790:Fish KW - Q1 08484:Species interactions: parasites and diseases KW - Q3 08587:Diseases of Cultured Organisms KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21184850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aquatic+Animal+Health&rft.atitle=Expanded+range+and+new+host+species+of+Mycobacterium+shottsii+and+M.+pseudoshottsii&rft.au=Stine%2C+Cynthia+B%3BJacobs%2C+John+M%3BRhodes%2C+Matt+R%3BOverton%2C+Anthony%3BFast%2C+Mark%3BBaya%2C+Ana+M&rft.aulast=Stine&rft.aufirst=Cynthia&rft.date=2009-09-01&rft.volume=21&rft.issue=3&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aquatic+Animal+Health&rft.issn=08997659&rft_id=info:doi/10.1577%2FH09-005.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Aquatic animals; Geographical distribution; Fish diseases; Fatty acids; Taxonomy; Diseases; Freshwater fish; Brackishwater fish; New species; Rivers; Islands; fatty acid methyl esters; Sound; Morone saxatilis; Morone americana; Mycobacterium shottsii; ANW, USA, North Carolina; USA, Maryland, Rhode R.; ANW, USA, North Carolina, Albemarle Sound; ANW, USA, New York, Long Island; ANW, USA, New York Bight; ANW, USA, Chesapeake Bay; ANW, USA, Maryland; Brackish DO - http://dx.doi.org/10.1577/H09-005.1 ER - TY - JOUR T1 - Anthrax Lethal Toxin Enhances IIoB Kinase Activation and Differentially Regulates Pro-inflammatory Genes in Human Endothelium AN - 21175017; 11259668 AB - Anthrax lethal toxin (LT) was previously shown to enhance transcriptional activity of NF-IoB in tumor necrosis factor-a-activated primary human endothelial cells. Here we show that this LT-mediated increase in NF-IoB activation is associated with the enhanced degradation of the inhibitory proteins IIoBa and IIoBb but not IIoBIek. Moreover, this was accompanied by enhanced activation of the IIoB kinase complex (IKK), which is responsible for targeting IIoB proteins for degradation. Importantly, LT enhancement of IIoBa degradation was completely blocked by a selective IKKb inhibitor, whereas IIoBb degradation was attenuated, suggesting a mechanistic link. Consistent with the above data, LT-cotreated cells show elevated phosphorylation of two IKK substrates IIoBa and p65, both of which were blocked by incubation with the IKKb inhibitor. Consistent with NF-IoB activation, LT increased transcription of the NF-IoB regulated gene CD40. Conversely, LT inhibited transcription of another NF-IoB-regulated gene, CCL2. This inhibition was linked to the LT-mediated suppression of another CCL2-regulating transcription factor, AP-1 (activator protein-1). These data suggest that LT-mediated enhancement of NF-IoB is IKK-dependent, but importantly, the net effect of LT on the transcription of proinflammatory genes is driven by the cumulative effect of LT on the particular set of transcription factors that regulate a given promoter. Together, these findings provide new mechanistic insight on how LT may disrupt the host response to anthrax. JF - Journal of Biological Chemistry AU - Warfel, Jason M AU - D'Agnillo, Felice AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, the Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, D. C. 20007 Y1 - 2009/09// PY - 2009 DA - Sep 2009 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 284 IS - 38 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts; Genetics Abstracts KW - Anthrax lethal toxin KW - Monocyte chemoattractant protein 1 KW - Data processing KW - Activator protein 1 KW - Tumor necrosis factor-a KW - IKK protein KW - Inflammation KW - Endothelial cells KW - Promoters KW - Phosphorylation KW - Transcription factors KW - Endothelium KW - Anthrax KW - CD40 antigen KW - G 07720:Immunogenetics KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21175017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Anthrax+Lethal+Toxin+Enhances+IIoB+Kinase+Activation+and+Differentially+Regulates+Pro-inflammatory+Genes+in+Human+Endothelium&rft.au=Warfel%2C+Jason+M%3BD%27Agnillo%2C+Felice&rft.aulast=Warfel&rft.aufirst=Jason&rft.date=2009-09-01&rft.volume=284&rft.issue=38&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M109.036970 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; Data processing; Monocyte chemoattractant protein 1; Activator protein 1; IKK protein; Tumor necrosis factor-a; Inflammation; Endothelial cells; Promoters; Phosphorylation; Transcription factors; Endothelium; Anthrax; CD40 antigen DO - http://dx.doi.org/10.1074/jbc.M109.036970 ER - TY - JOUR T1 - External L5-S1 joint moments when lifting wire mesh screen used to prevent rock falls in underground mines AN - 21124407; 11057955 AB - Bolting large sheets of wire mesh screen (WMS) to the roof of underground mines prevents injuries due to rock falls. However, WMS can be heavy and awkward to lift and transport, and may result in significant spinal loading. Accordingly, six male subjects (mean age = 45.8 years + 7.5 SD) were recruited to lift WMS in a laboratory investigation of the biomechanical demands. Biomechanical modeling was used to estimate external moments about L5-S1 for sixteen lifting tasks, using two sizes of WMS. Full-size WMS involved a two-person lift, while half-size WMS involved a one-person lift. Lifts were performed under 168 cm and 213 cm vertical space. Restriction in vertical space increased the maximum L5-S1 extensor moment from 254 to 274 Nm and right lateral bending moment from 195 to 251 Nm. Lifting full sheets of screen (as opposed to half sheets) resulted in an average 33 Nm increase in L5-S1 extensor moment. The L5-S1 extensor moment was increased by an average of 44 Nm (18%) when lifting screens positioned flat on the floor compared to an upright position. Relevance to industry - Large flexible materials are commonly lifted in industrial work environments, and may involve the efforts of two or more workers. The current study examines the low back loading associated with lifting large flexible screens and presents recommendations to reduce spine loading. JF - International Journal of Industrial Ergonomics AU - Gallagher, Sean AU - Kotowski, Susan AU - Davis, Kermit G AU - Mark, Christopher AU - Compton, Craig S AU - Huston, Ronald L AU - Connelly, John AD - National Institute for Occupational Safety and Health, PO Box 18070, Pittsburgh, PA 15236, USA, sfg9@cdc.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 828 EP - 834 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 39 IS - 5 SN - 0169-8141, 0169-8141 KW - Health & Safety Science Abstracts KW - Age KW - spine KW - Injuries KW - biomechanics KW - Mines KW - working conditions KW - lifting KW - Ergonomics KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21124407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=External+L5-S1+joint+moments+when+lifting+wire+mesh+screen+used+to+prevent+rock+falls+in+underground+mines&rft.au=Gallagher%2C+Sean%3BKotowski%2C+Susan%3BDavis%2C+Kermit+G%3BMark%2C+Christopher%3BCompton%2C+Craig+S%3BHuston%2C+Ronald+L%3BConnelly%2C+John&rft.aulast=Gallagher&rft.aufirst=Sean&rft.date=2009-09-01&rft.volume=39&rft.issue=5&rft.spage=828&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2009.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - lifting; Mines; biomechanics; Ergonomics; working conditions; spine; Injuries; Age DO - http://dx.doi.org/10.1016/j.ergon.2009.01.005 ER - TY - JOUR T1 - Pulmonary nontuberculous mycobacterial infections in hyper-IgE syndrome AN - 21097313; 11088480 JF - Journal of Allergy and Clinical Immunology AU - Melia, Elizabeth AU - Freeman, Alexandra F AU - Shea, Yvonne R AU - Hsu, Amy P AU - Holland, Steven M AU - Olivier, Kenneth N AD - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Md, olivierk@niaid.nih.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 617 EP - 618 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA VL - 124 IS - 3 SN - 0091-6749, 0091-6749 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mycobacterium KW - Lung KW - Infection KW - Job's syndrome KW - F 06925:Hypersensitivity KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21097313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Pulmonary+nontuberculous+mycobacterial+infections+in+hyper-IgE+syndrome&rft.au=Melia%2C+Elizabeth%3BFreeman%2C+Alexandra+F%3BShea%2C+Yvonne+R%3BHsu%2C+Amy+P%3BHolland%2C+Steven+M%3BOlivier%2C+Kenneth+N&rft.aulast=Melia&rft.aufirst=Elizabeth&rft.date=2009-09-01&rft.volume=124&rft.issue=3&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2009.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Lung; Infection; Job's syndrome; Mycobacterium DO - http://dx.doi.org/10.1016/j.jaci.2009.07.007 ER - TY - JOUR T1 - Relationships between observational estimates and physical measurements of upper limb activity AN - 21078751; 11101375 AB - Abstract not available. JF - Ergonomics AU - Lowe, Brian D AU - Krieg, Edward F AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 1183 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 52 IS - 9 SN - 0014-0139, 0014-0139 KW - Physical Education Index KW - PE 070:Measurement & Evaluation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21078751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Relationships+between+observational+estimates+and+physical+measurements+of+upper+limb+activity&rft.au=Lowe%2C+Brian+D%3BKrieg%2C+Edward+F&rft.aulast=Lowe&rft.aufirst=Brian&rft.date=2009-09-01&rft.volume=52&rft.issue=9&rft.spage=1183&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130903148761 LA - English DB - Physical Education Index N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/00140130903148761 ER - TY - JOUR T1 - Occupational Exposure and Autism Spectrum Disorder AN - 20966894; 11044529 JF - Annals of Epidemiology AU - McCanlies, E C AU - Charles, LE AU - Fekedulegn, D AU - Mnatsakanova, A AU - Burchfiel, C AU - Sanderson, W T AU - Croen, LA AU - Hertz-Picciotto, I AD - NIOSH, Morgantown, WV Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 659 EP - 660 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 19 IS - 9 SN - 1047-2797, 1047-2797 KW - Health & Safety Science Abstracts KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20966894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Occupational+Exposure+and+Autism+Spectrum+Disorder&rft.au=McCanlies%2C+E+C%3BCharles%2C+LE%3BFekedulegn%2C+D%3BMnatsakanova%2C+A%3BBurchfiel%2C+C%3BSanderson%2C+W+T%3BCroen%2C+LA%3BHertz-Picciotto%2C+I&rft.aulast=McCanlies&rft.aufirst=E&rft.date=2009-09-01&rft.volume=19&rft.issue=9&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2009.07.062 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Occupational exposure DO - http://dx.doi.org/10.1016/j.annepidem.2009.07.062 ER - TY - JOUR T1 - Prevalence of Lifetime Asthma and Current Asthma Attacks in U.S. Working Adults: An Analysis of the 1997-2004 National Health Interview Survey Data AN - 20960831; 11060889 AB - Objective: To estimate national prevalences of lifetime asthma and asthma attacks among workers by age, sex, race, occupation and industry, and estimate population attributable fraction to employment for asthma attacks in the United States. Methods: The 1997-2004 National Health Interview Survey data for currently working adults aged greater than or equal to 18 years were analyzed. Results: Lifetime asthma prevalence was 9.2%; the social services religious and membership organizations industry and the health service occupation had the highest asthma prevalence. Asthma attack prevalence among workers with asthma was 35.4%; the primary metal industry and the health assessment and treating occupation had the highest attack prevalence. Approximately, 5.9% of cases reporting an asthma attack were attributed to employment when considering industries and 3.8% when considering occupations. Conclusions: Future studies and intervention strategies should address the higher prevalence of asthma in certain industries and occupations. JF - Journal of Occupational and Environmental Medicine AU - Syamlal, G AU - Mazurek, J M AU - Bang, K M AD - National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mail Stop HG900.2, Morgantown, WV 26505, gos2@cdc.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 1066 EP - 1074 VL - 51 IS - 9 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - social services KW - USA KW - Age KW - employment KW - occupational diseases KW - intervention KW - Asthma KW - Respiratory diseases KW - Metal industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20960831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Prevalence+of+Lifetime+Asthma+and+Current+Asthma+Attacks+in+U.S.+Working+Adults%3A+An+Analysis+of+the+1997-2004+National+Health+Interview+Survey+Data&rft.au=Syamlal%2C+G%3BMazurek%2C+J+M%3BBang%2C+K+M&rft.aulast=Syamlal&rft.aufirst=G&rft.date=2009-09-01&rft.volume=51&rft.issue=9&rft.spage=1066&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181b3510a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - social services; Age; employment; occupational diseases; intervention; Asthma; Respiratory diseases; Metal industry; USA DO - http://dx.doi.org/10.1097/JOM.0b013e3181b3510a ER - TY - JOUR T1 - Oesophageal cancer incidence in the United States by race, sex, and histologic type, 1977-2005 AN - 20801372; 10915086 AB - Background:In the United States, the rates and temporal trends of oesophageal cancer overall and for the two predominant histologic types - adenocarcinoma (ADC) and squamous cell carcinoma (SCC) - differ between Blacks and Whites, but little is known with regard to the patterns among Asians/Pacific Islanders or Hispanics. Methods:Using the Surveillance, Epidemiology, and End Results programme data, we analysed oesophageal cancer incidence patterns by race, sex, and histologic type for the period 1977-2005. Results:Total oesophageal cancer incidence has been increasing among Whites only; the rates among all other race groups have declined. Moreover, rates among White men surpassed those among Blacks in 2004. Oesophageal SCC rates have been decreasing among virtually all racial/ethnic groups; rates among Hispanic and Asian/Pacific Islander men have been intermediate to those of Blacks and Whites, with rates among women being lower than those among Blacks or Whites. The ADC rates among Hispanic men may be rising, akin to the historical trends among Whites and Blacks. The sex ratios for these cancers also varied markedly. Conclusions:These observations may provide clues for aetiological research. JF - British Journal of Cancer AU - Cook, M B AU - Chow, W-H AU - Devesa, S S AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2009/09/01/ PY - 2009 DA - 2009 Sep 01 SP - 855 EP - 859 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 101 IS - 5 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Historical account KW - USA KW - I, Pacific KW - sex ratio KW - Ethnic groups KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20801372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Oesophageal+cancer+incidence+in+the+United+States+by+race%2C+sex%2C+and+histologic+type%2C+1977-2005&rft.au=Cook%2C+M+B%3BChow%2C+W-H%3BDevesa%2C+S+S&rft.aulast=Cook&rft.aufirst=M&rft.date=2009-09-01&rft.volume=101&rft.issue=5&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605246 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; I, Pacific; Cancer; Historical account; Ethnic groups; sex ratio DO - http://dx.doi.org/10.1038/sj.bjc.6605246 ER - TY - JOUR T1 - Microarray analysis of antimicrobial resistance genes in Salmonella enterica from preharvest poultry environment AN - 20797716; 10844965 AB - AbstractAims: To detect antimicrobial resistance genes in Salmonella isolates from turkey flocks using the microarray technology.Methods and Results: A 775 gene probe oligonucleotide microarray was used to detect antimicrobial resistance genes in 34 isolates. All tetracycline-resistant Salmonella harboured tet(A), tet(C) or tet(R), with the exception of one Salmonella serotype Heidelberg isolate. The sul1 gene was detected in 11 of 16 sulfisoxazole-resistant isolates. The aadA, aadA1, aadA2, strA or strB genes were found in aminoglycoside-resistant isolates of Salm. Heidelberg, Salmonella serotype Senftenberg and untypeable Salmonella. The prevalence of mobile genetic elements, such as class I integron and transposon genes, in drug-resistant Salmonella isolates suggested that these elements may contribute to the dissemination of antimicrobial resistance genes in the preharvest poultry environment. Hierarchical clustering analysis demonstrated a close relationship between drug-resistant phenotypes and the corresponding antimicrobial resistance gene profiles.Conclusions: Salmonella serotypes isolated from the poultry environment carry multiple genes that can render them resistant to several antimicrobials used in poultry and humans.Significance and Impact of the Study: Multiple antimicrobial resistance genes in environmental Salmonella isolates could be identified efficiently by microarray analysis. Hierarchical clustering analysis of the data was also found to be a useful tool for analysing emerging patterns of drug resistance. JF - Journal of Applied Microbiology AU - Zou, W AU - Frye, J G AU - Chang, C-W AU - Liu, J AU - Cerniglia, CE AU - Nayak, R AD - 1 Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 906 EP - 914 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 107 IS - 3 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - antimicrobial resistance genes KW - hierarchical analysis KW - microarray KW - poultry KW - Salmonella KW - turkey KW - Transposons KW - sul1 gene KW - Poultry KW - Serotypes KW - Data processing KW - Salmonella enterica KW - Drug resistance KW - Probes KW - Oligonucleotides KW - Antimicrobial agents KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - X 24320:Food Additives & Contaminants KW - W 30915:Pharmaceuticals & Vaccines KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20797716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Microarray+analysis+of+antimicrobial+resistance+genes+in+Salmonella+enterica+from+preharvest+poultry+environment&rft.au=Zou%2C+W%3BFrye%2C+J+G%3BChang%2C+C-W%3BLiu%2C+J%3BCerniglia%2C+CE%3BNayak%2C+R&rft.aulast=Zou&rft.aufirst=W&rft.date=2009-09-01&rft.volume=107&rft.issue=3&rft.spage=906&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fj.1365-2672.2009.04270.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Transposons; sul1 gene; Poultry; Data processing; Serotypes; Drug resistance; Probes; Oligonucleotides; Antimicrobial agents; Salmonella enterica DO - http://dx.doi.org/10.1111/j.1365-2672.2009.04270.x ER - TY - JOUR T1 - Preliminary evaluation of a procedure for improved detection of Shiga toxin-producing Escherichia coli in fecal specimens AN - 20214205; 10314777 AB - Culture confirmation of Shiga toxin-producing Escherichia coli (STEC) is very important for epidemiologic analysis. However, isolation of non-O157 STEC on conventional selective media such as sorbitol-MacConkey agar (SMAC) can be difficult because of heavy growth of competing bacteria and its phenotypical similarity to commensal nonpathogenic E. coli. An acid enrichment procedure was introduced in this study to facilitate detection of STEC from patients who were symptomatic. Forty-seven clinical fecal broths, which tested positive for Shiga toxin by commercial immunoassay, were processed for the isolation of STEC by both conventional and the acid enrichment methods. The acid enrichment method and conventional culture recovered STEC from 91% (43/47) and 70% (33 /47) of the fecal broths, respectively. Neither method retrieved STEC in 3 specimens. Thirty-six STEC were successfully serogrouped, which included O26 (n = 11), O157 (n = 9), O103 (n = 7), O121 (n = 3), O111 (n = 2 each), O28AC, O146, O76, and O undetermined (n = 1 each). The analysis of STEC isolates by real-time PCR indicated that all 9 E. coli O157 contained stx2 gene alone or in combination with stx1. Non-O157 STEC more frequently contained stx1 only, and about one-third possessed stx2. The novel acid enrichment protocol greatly reduced the growth of competitor colonies on RTN and TCSMAC. The study demonstrated that incorporation of an acid enrichment procedure in clinical testing improved the isolation of STEC in fecal specimens. JF - Diagnostic Microbiology and Infectious Disease AU - Hu, J AU - Green, D AU - Swoveland, J AU - Grant, M AU - Boyle, D S AD - Bothell, WA 98021, USA, jinxin.hu@fda.hhs.gov Y1 - 2009/09// PY - 2009 DA - September 2009 SP - 21 EP - 26 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 65 IS - 1 SN - 0732-8893, 0732-8893 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Agar KW - Colonies KW - DIABLO protein KW - stx2 gene KW - Escherichia coli KW - Commensals KW - Polymerase chain reaction KW - Media (selective) KW - Immunoassays KW - Shiga toxin KW - X 24310:Pharmaceuticals KW - J 02400:Human Diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20214205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=Preliminary+evaluation+of+a+procedure+for+improved+detection+of+Shiga+toxin-producing+Escherichia+coli+in+fecal+specimens&rft.au=Hu%2C+J%3BGreen%2C+D%3BSwoveland%2C+J%3BGrant%2C+M%3BBoyle%2C+D+S&rft.aulast=Hu&rft.aufirst=J&rft.date=2009-09-01&rft.volume=65&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2009.05.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Agar; DIABLO protein; Colonies; stx2 gene; Commensals; Polymerase chain reaction; Immunoassays; Media (selective); Shiga toxin; Escherichia coli DO - http://dx.doi.org/10.1016/j.diagmicrobio.2009.05.012 ER - TY - JOUR T1 - Federal Declaration of a Public Health Emergency AN - 1257770455; 17458488 AB - During certain emergencies (naturally caused or deliberate) that can have a significant impact on the public's health, the Secretary of the U.S. Department of Health and Human Services (HHS) has broad discretion to declare a Public Health Emergency (PHE). While many public health emergencies will not require a formal declaration, this type of declaration can be an important and necessary step to authorize the secretary to take a variety of actions that enable the department to respond optimally to an emergency. This article outlines the HHS Secretary's PHE authority, discusses possible discretionary actions that the secretary may take after declaring a PHE, and provides examples of PHE declarations that have been issued. JF - Biosecurity and Bioterrorism AU - Ray, J AD - U.S. Dept of Health and Human Services, Office of the General Counsel, Public Health Division, 200 Independence Ave., SW, Suite 638-G, #49, Washington, DC 20201, USA, jennifer.ray@hhs.gov Y1 - 2009/09// PY - 2009 DA - Sep 2009 SP - 251 EP - 258 VL - 7 IS - 3 SN - 1538-7135, 1538-7135 KW - Health & Safety Science Abstracts KW - USA KW - bioterrorism KW - Disasters KW - Public health KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1257770455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosecurity+and+Bioterrorism&rft.atitle=Federal+Declaration+of+a+Public+Health+Emergency&rft.au=Ray%2C+J&rft.aulast=Ray&rft.aufirst=J&rft.date=2009-09-01&rft.volume=7&rft.issue=3&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Biosecurity+and+Bioterrorism&rft.issn=15387135&rft_id=info:doi/10.1089%2Fbsp.2009.0039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - bioterrorism; Disasters; Public health; USA DO - http://dx.doi.org/10.1089/bsp.2009.0039 ER - TY - CPAPER T1 - Staphylococcus aureus biofilms: Vaccine development and the host immune response T2 - 2009 Gordon Research Conference on Staphylococcal Diseases AN - 42378908; 5378622 JF - 2009 Gordon Research Conference on Staphylococcal Diseases AU - Brady, Rebecca Y1 - 2009/08/30/ PY - 2009 DA - 2009 Aug 30 KW - Immune response KW - Vaccines KW - Biofilms KW - Immunity KW - Defense mechanisms KW - Disease control KW - Staphylococcus aureus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42378908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Staphylococcal+Diseases&rft.atitle=Staphylococcus+aureus+biofilms%3A+Vaccine+development+and+the+host+immune+response&rft.au=Brady%2C+Rebecca&rft.aulast=Brady&rft.aufirst=Rebecca&rft.date=2009-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Staphylococcal+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=staph LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Whole-body Vibration Exposures for Haulage Truck and Loader Operators in Quarry Operations T2 - 2009 American Society of Mechanical Engineers International Design Engineering Technical Conferences (IDETC/CIE 2009) AN - 42315289; 5343130 JF - 2009 American Society of Mechanical Engineers International Design Engineering Technical Conferences (IDETC/CIE 2009) AU - Mayton, Alan Y1 - 2009/08/30/ PY - 2009 DA - 2009 Aug 30 KW - Vibration KW - Quarries KW - Trucks KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42315289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Society+of+Mechanical+Engineers+International+Design+Engineering+Technical+Conferences+%28IDETC%2FCIE+2009%29&rft.atitle=Evaluation+of+Whole-body+Vibration+Exposures+for+Haulage+Truck+and+Loader+Operators+in+Quarry+Operations&rft.au=Mayton%2C+Alan&rft.aulast=Mayton&rft.aufirst=Alan&rft.date=2009-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Society+of+Mechanical+Engineers+International+Design+Engineering+Technical+Conferences+%28IDETC%2FCIE+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asmeconferences.org/IDETC09/ConferenceSchedule.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - RPRT T1 - Summary of Advances in Autism Spectrum Disorder Research: Calendar Year 2008 AN - 742872796; ED509369 AB - In response to the alarming growth in autism diagnoses, Congress passed the Combating Autism Act of 2006 (P.L. 109-416), which established the Interagency Autism Coordinating Committee (IACC) to coordinate all efforts within the U.S. Department of Health and Human Services related to ASD. The Combating Autism Act requires that, in addition to several other key responsibilities, the IACC must prepare an annual summary of advances in autism research. The 2008 IACC Summary of Advances highlights 37 significant studies on autism spectrum disorder selected by members of the IACC. A bulleted overview of the major findings in 2008 is followed by a more detailed description of the scientific breakthroughs in each category. Information about funding sources and journal impact factor scores is included in a table at the end of the document. This year's advances are sorted into six topic areas that correspond to six critical questions for those affected by ASD: (1) Diagnosis: When should I be concerned?; (2) Biology: How can I understand what is happening?; (3) Risk Factors: What caused this to happen and can this be prevented?; (4) Treatment: Which treatments and interventions will help?; (5) Services: Where can I turn for services?; and (6) Outcomes: What does the future hold? (Contains 54 footnotes.) Y1 - 2009/08/28/ PY - 2009 DA - 2009 Aug 28 SP - 27 PB - Interagency Autism Coordinating Committee. US Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Financial Support KW - At Risk Persons KW - Etiology KW - Clinical Diagnosis KW - Pervasive Developmental Disorders KW - Intervention KW - Factor Analysis KW - Genetics KW - Health Services KW - Human Services KW - Federal Legislation KW - Access to Health Care KW - Research KW - Autism KW - Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742872796?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - CPAPER T1 - Facial Shape Variation of U.S. Respirator Users T2 - International Conference on Human Computer Interaction (ICHCI 2009) AN - 42352427; 5373497 JF - International Conference on Human Computer Interaction (ICHCI 2009) AU - Zhuang, Ziqing AU - Slice, Dennis AU - Benson, Stacey AU - Landsittel, Douglas AU - Viscusi, Dennis Y1 - 2009/08/26/ PY - 2009 DA - 2009 Aug 26 KW - USA KW - Respirators KW - Protective equipment KW - Respiration KW - Metabolism KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42352427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=International+Conference+on+Human+Computer+Interaction+%28ICHCI+2009%29&rft.atitle=Facial+Shape+Variation+of+U.S.+Respirator+Users&rft.au=Zhuang%2C+Ziqing%3BSlice%2C+Dennis%3BBenson%2C+Stacey%3BLandsittel%2C+Douglas%3BViscusi%2C+Dennis&rft.aulast=Zhuang&rft.aufirst=Ziqing&rft.date=2009-08-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Conference+on+Human+Computer+Interaction+%28ICHCI+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.hcii2009.org/program.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple Endpoints in Vaccine Trials T2 - 30th Annual Conference of the International Society for Clinical Biostatistics (ISCB 2009) AN - 40336810; 5268846 JF - 30th Annual Conference of the International Society for Clinical Biostatistics (ISCB 2009) AU - Hsu, Henry Y1 - 2009/08/23/ PY - 2009 DA - 2009 Aug 23 KW - Clinical trials KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Conference+of+the+International+Society+for+Clinical+Biostatistics+%28ISCB+2009%29&rft.atitle=Multiple+Endpoints+in+Vaccine+Trials&rft.au=Hsu%2C+Henry&rft.aulast=Hsu&rft.aufirst=Henry&rft.date=2009-08-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Conference+of+the+International+Society+for+Clinical+Biostatistics+%28ISCB+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb2009.info/RSystem/Soubory/ISCB09_Prog_AbsBook_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Risk of Suicidality in Clinical Trials of Antidepressants in Adults: Analysis of Proprietary Data Submitted to US Food and Drug Administration AN - 57299671; 200927911 AB - Objective: To examine the risk of suicidal behaviour within clinical trials of antidepressants in adults. Design: Meta-analysis of 372 double blind randomised placebo controlled trials. Setting: Drug development programmes for any indication in adults. Participants: 99 231 adults assigned to antidepressants or placebo. Median age was 42 and 63.1% were women. Indications for treatment were major depression (45.6%), other depression (4.6%), other psychiatric disorders (27.6%), and non-psychiatric disorders (22.2%). Main outcome measures: Suicidal behaviour (completed suicide, attempted suicide, or preparatory acts) and ideation. Results: For participants with non-psychiatric indications, suicidal behaviour and ideation were extremely rare. For those with psychiatric indications, risk was associated with age. For suicidal behaviour or ideation and for suicidal behaviour only, the respective odds ratios were 1.62 (95% confidence interval 0.97 to 2.71) and 2.30 (1.04 to 5.09) for participants aged 65. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Stone, Marc AU - Laughren, Thomas AU - Jones, M Lisa AU - Levenson, Mark AU - Holland, P Chris AU - Hughes, Alice AU - Hammad, Tarek A AU - Temple, Robert AU - Rochester, George AD - Center Drug Evaluation & Research, US Food & Drug Administration, Silver Spring, MD marc.stone@fda.hhs.gov Y1 - 2009/08/22/ PY - 2009 DA - 2009 Aug 22 SP - 431 EP - 434 PB - British Medical Association, BMJ Publishing Group, London UK VL - 339 IS - 7718 SN - 0959-535X, 0959-535X KW - Ideation KW - Suicidal behaviour KW - Depression KW - Suicidal ideation KW - Antidepressant drugs KW - Clinical trials KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57299671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Risk+of+Suicidality+in+Clinical+Trials+of+Antidepressants+in+Adults%3A+Analysis+of+Proprietary+Data+Submitted+to+US+Food+and+Drug+Administration&rft.au=Stone%2C+Marc%3BLaughren%2C+Thomas%3BJones%2C+M+Lisa%3BLevenson%2C+Mark%3BHolland%2C+P+Chris%3BHughes%2C+Alice%3BHammad%2C+Tarek+A%3BTemple%2C+Robert%3BRochester%2C+George&rft.aulast=Stone&rft.aufirst=Marc&rft.date=2009-08-22&rft.volume=339&rft.issue=7718&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/10.1136%2Fbmj.b2880 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-11-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Suicidal behaviour; Antidepressant drugs; Ideation; Clinical trials; Suicidal ideation; Depression DO - http://dx.doi.org/10.1136/bmj.b2880 ER - TY - JOUR T1 - Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial. AN - 67592165; 19687490 AB - Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases. To compare the benefits and side effects of TwHF extract with those of sulfasalazine for the treatment of active rheumatoid arthritis. Randomized, controlled trial. A computer-generated code with random, permuted blocks was used to assign treatment. 2 U.S. academic centers (National Institutes of Health, Bethesda, Maryland, and University of Texas, Dallas, Texas) and 9 rheumatology subspecialty clinics (in Dallas and Austin, Texas; Tampa and Fort Lauderdale, Florida; Arlington, Virginia; Duncanville, Pennsylvania; Wheaton and Greenbelt, Maryland; and Lansing, Michigan). 121 patients with active rheumatoid arthritis and 6 or more painful and swollen joints. TwHF extract, 60 mg 3 times daily, or sulfasalazine, 1 g twice daily. Patients could continue stable doses of oral prednisone or nonsteroidal anti-inflammatory drugs but had to stop taking disease-modifying antirheumatic drugs at least 28 days before randomization. The primary outcome was the rate of achievement of 20% improvement in the American College of Rheumatology criteria (ACR 20) at 24 weeks. Secondary end points were safety; radiographic scores of joint damage; and serum levels of interleukin-6, cholesterol, cortisol, and adrenocorticotropic hormone. Outcome data were available for only 62 patients at 24 weeks. In a mixed-model analysis that imputed data for patients who dropped out, 65.0% (95% CI, 51.6% to 76.9%) of the TwHF group and 32.8% (CI, 21.3% to 46.0%) of the sulfasalazine group met the ACR 20 response criteria (P=0.001). Patients receiving TwHF also had significantly higher response rates for ACR 50 and ACR 70 in mixed-model analyses. Analyses of only completers showed similar significant differences between the treatment groups. Significant improvement was demonstrated in all individual components of the ACR response, including the Health Assessment Questionnaire disability score. Interleukin-6 levels rapidly and significantly decreased in the TwHF group. Although not statistically significant, radiographic progression was lower in the TwHF group. The frequency of adverse events was similar in both groups. Only 62% and 41% of patients continued receiving TwHF extract and sulfasalazine, respectively, during the 24 weeks of the study. Long-term outcome data were not collected on participants who discontinued treatment. In patients who continued treatment for 24 weeks and could also use stable oral prednisone and nonsteroidal anti-inflammatory drugs, attainment of the ACR 20 response criteria was significantly greater with TwHF extract than with sulfasalazine. JF - Annals of internal medicine AU - Goldbach-Mansky, Raphaela AU - Wilson, Mildred AU - Fleischmann, Roy AU - Olsen, Nancy AU - Silverfield, Joel AU - Kempf, Phillip AU - Kivitz, Alan AU - Sherrer, Yvonne AU - Pucino, Frank AU - Csako, Gyorgy AU - Costello, Rene AU - Pham, Tuyet Hang AU - Snyder, Christopher AU - van der Heijde, Désirée AU - Tao, Xuelian AU - Wesley, Robert AU - Lipsky, Peter E AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases and Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892-0001, USA. goldbacr@mail.nih.gov Y1 - 2009/08/18/ PY - 2009 DA - 2009 Aug 18 SP - 229 EP - 40, W49-51 VL - 151 IS - 4 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Antirheumatic Agents KW - Plant Extracts KW - Sulfasalazine KW - 3XC8GUZ6CB KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Patient Compliance KW - Prednisone -- therapeutic use KW - Humans KW - Adult KW - Gastrointestinal Diseases -- chemically induced KW - Aged KW - Middle Aged KW - Male KW - Female KW - Arthritis, Rheumatoid -- drug therapy KW - Plant Extracts -- therapeutic use KW - Antirheumatic Agents -- adverse effects KW - Sulfasalazine -- adverse effects KW - Tripterygium KW - Sulfasalazine -- therapeutic use KW - Plant Extracts -- adverse effects KW - Phytotherapy -- adverse effects KW - Antirheumatic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67592165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Comparison+of+Tripterygium+wilfordii+Hook+F+versus+sulfasalazine+in+the+treatment+of+rheumatoid+arthritis%3A+a+randomized+trial.&rft.au=Goldbach-Mansky%2C+Raphaela%3BWilson%2C+Mildred%3BFleischmann%2C+Roy%3BOlsen%2C+Nancy%3BSilverfield%2C+Joel%3BKempf%2C+Phillip%3BKivitz%2C+Alan%3BSherrer%2C+Yvonne%3BPucino%2C+Frank%3BCsako%2C+Gyorgy%3BCostello%2C+Rene%3BPham%2C+Tuyet+Hang%3BSnyder%2C+Christopher%3Bvan+der+Heijde%2C+D%C3%A9sir%C3%A9e%3BTao%2C+Xuelian%3BWesley%2C+Robert%3BLipsky%2C+Peter+E&rft.aulast=Goldbach-Mansky&rft.aufirst=Raphaela&rft.date=2009-08-18&rft.volume=151&rft.issue=4&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-25 N1 - Date created - 2009-08-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Arthritis Rheum. 2000 Aug;43(8):1809-19 [10943871] Cochrane Database Syst Rev. 2000;(2):CD000958 [10796400] J Tradit Chin Med. 2001 Mar;21(1):50-1 [11360541] Se Pu. 1998 Jul;16(4):356-7 [11367766] Acta Pharmacol Sin. 2000 Sep;21(9):782-6 [11501157] Arthritis Rheum. 2001 Sep;44(9):1984-92 [11592358] J Rheumatol. 2001 Oct;28(10):2160-7 [11669150] Arthritis Rheum. 2002 Jul;46(7):1735-43 [12124856] Contraception. 2002 Jun;65(6):441-5 [12127645] Drugs R D. 2003;4(1):1-18 [12568630] Nature. 2003 May 15;423(6937):356-61 [12748655] N Engl J Med. 2004 Jun 17;350(25):2591-602 [15201416] Arthritis Rheum. 2004 Sep;50(9):2995-303 [15457469] J Am Chem Soc. 1972 Oct 4;94(20):7194-5 [5072337] Lancet. 1987 May 16;1(8542):1108-11 [2883443] Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1987 Oct;9(5):317-22 [2968853] Zhonghua Xin Xue Guan Bing Za Zhi. 1989 Aug;17(4):236-7 [2627881] Arch Intern Med. 1993 Jun 14;153(11):1337-42 [8507124] J Pharmacol Exp Ther. 1995 Mar;272(3):1305-12 [7891348] Arthritis Rheum. 1995 Jun;38(6):727-35 [7779114] Arthritis Rheum. 1998 Jan;41(1):130-8 [9433878] Lancet. 1999 Jan 23;353(9149):259-66 [9929017] J Biol Chem. 1999 May 7;274(19):13443-50 [10224109] J Biol Chem. 1999 May 7;274(19):13451-5 [10224110] Transplant Proc. 1999 Aug;31(5):2056-7 [10455969] Am J Chin Med. 2005;33(6):945-55 [16355451] Arthritis Rheum. 2006 Apr;54(4):1063-74 [16572441] Ann Intern Med. 2006 Jun 20;144(12):865-76 [16785475] Transplant Proc. 2006 Jun;38(5):1274-9 [16797280] Ann N Y Acad Sci. 2006 Jun;1069:414-9 [16855168] Arthritis Rheum. 2006 Sep;54(9):2793-806 [16947627] Biomed Pharmacother. 2006 Dec;60(10):688-92 [17049202] Phytochemistry. 2007 Mar;68(6):732-66 [17250858] Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4389-94 [17360534] Dig Dis Sci. 2007 Aug;52(8):1790-7 [17410440] Ann Rheum Dis. 2007 Sep;66(9):1162-7 [17485422] Lancet. 2007 Dec 1;370(9602):1861-74 [17570481] Ann Intern Med. 2008 Jan 15;148(2):124-34 [18025440] Rheumatology (Oxford). 2000 Sep;39(9):975-81 [10986302] J Rheumatol. 2000 Jan;27(1):261-3 [10648051] Rheum Dis Clin North Am. 2000 Feb;26(1):29-50, viii [10680192] Arthritis Rheum. 2000 Mar;43(3):495-505 [10728741] Summary For Patients In: Ann Intern Med. 2009 Aug 18;151(4):I-36 [19687475] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Treatments for nicotine addiction should be a top priority. AN - 67585884; 19394686 JF - Lancet (London, England) AU - Pollock, Jonathan D AU - Koustova, Elena AU - Hoffman, Allison AU - Shurtleff, David AU - Volkow, Nora D AD - National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA. jpollock@mail.nih.gov Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 513 EP - 514 VL - 374 IS - 9689 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Smoking Cessation KW - Healthy People Programs KW - United States -- epidemiology KW - Cause of Death KW - Research Support as Topic KW - Health Services Needs and Demand KW - Tobacco Use Disorder -- therapy KW - Tobacco Use Disorder -- epidemiology KW - Tobacco Use Disorder -- complications KW - Health Priorities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67585884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Treatments+for+nicotine+addiction+should+be+a+top+priority.&rft.au=Pollock%2C+Jonathan+D%3BKoustova%2C+Elena%3BHoffman%2C+Allison%3BShurtleff%2C+David%3BVolkow%2C+Nora+D&rft.aulast=Pollock&rft.aufirst=Jonathan&rft.date=2009-08-15&rft.volume=374&rft.issue=9689&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/10.1016%2FS0140-6736%2809%2960352-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-27 N1 - Date created - 2009-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2000 Jun 14;283(22):2975-8 [10865276] Am J Prev Med. 2008 Feb;34(2):102-11 [18201639] MMWR Morb Mortal Wkly Rep. 2005 Jul 1;54(25):625-8 [15988406] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0140-6736(09)60352-4 ER - TY - JOUR T1 - Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. AN - 67535997; 19561064 AB - Smoking is an established risk factor for pancreatic cancer; however, detailed examination of the association of smoking intensity, smoking duration, and cumulative smoking dose with pancreatic cancer is limited. The authors analyzed pooled data from the international Pancreatic Cancer Cohort Consortium nested case-control study (1,481 cases, 1,539 controls). Odds ratios and 95% confidence intervals were calculated by using unconditional logistic regression. Smoking intensity effects were examined with an excess odds ratio model that was linear in pack-years and exponential in cigarettes smoked per day and its square. When compared with never smokers, current smokers had a significantly elevated risk (odds ratio (OR) = 1.77, 95% confidence interval (CI): 1.38, 2.26). Risk increased significantly with greater intensity (> or =30 cigarettes/day: OR = 1.75, 95% CI: 1.27, 2.42), duration (> or =50 years: OR = 2.13, 95% CI: 1.25, 3.62), and cumulative smoking dose (> or =40 pack-years: OR = 1.78, 95% CI: 1.35, 2.34). Risk more than 15 years after smoking cessation was similar to that for never smokers. Estimates of excess odds ratio per pack-year declined with increasing intensity, suggesting greater risk for total exposure delivered at lower intensity for longer duration than for higher intensity for shorter duration. This finding and the decline in risk after smoking cessation suggest that smoking has a late-stage effect on pancreatic carcinogenesis. JF - American journal of epidemiology AU - Lynch, Shannon M AU - Vrieling, Alina AU - Lubin, Jay H AU - Kraft, Peter AU - Mendelsohn, Julie B AU - Hartge, Patricia AU - Canzian, Federico AU - Steplowski, Emily AU - Arslan, Alan A AU - Gross, Myron AU - Helzlsouer, Kathy AU - Jacobs, Eric J AU - LaCroix, Andrea AU - Petersen, Gloria AU - Zheng, Wei AU - Albanes, Demetrius AU - Amundadottir, Laufey AU - Bingham, Sheila A AU - Boffetta, Paolo AU - Boutron-Ruault, Marie-Christine AU - Chanock, Stephen J AU - Clipp, Sandra AU - Hoover, Robert N AU - Jacobs, Kevin AU - Johnson, Karen C AU - Kooperberg, Charles AU - Luo, Juhua AU - Messina, Catherine AU - Palli, Domenico AU - Patel, Alpa V AU - Riboli, Elio AU - Shu, Xiao-Ou AU - Rodriguez Suarez, Laudina AU - Thomas, Gilles AU - Tjønneland, Anne AU - Tobias, Geoffrey S AU - Tong, Elissa AU - Trichopoulos, Dimitrios AU - Virtamo, Jarmo AU - Ye, Weimin AU - Yu, Kai AU - Zeleniuch-Jacquette, Anne AU - Bueno-de-Mesquita, H Bas AU - Stolzenberg-Solomon, Rachael Z AD - National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA. lynchs@mail.nih.gov Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 403 EP - 413 VL - 170 IS - 4 KW - Index Medicus KW - Risk KW - Prospective Studies KW - Aged, 80 and over KW - Humans KW - Cohort Studies KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Smoking Cessation -- statistics & numerical data KW - Adenocarcinoma -- epidemiology KW - Adenocarcinoma -- etiology KW - Smoking -- adverse effects KW - Pancreatic Neoplasms -- epidemiology KW - Smoking -- epidemiology KW - Pancreatic Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67535997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Cigarette+smoking+and+pancreatic+cancer%3A+a+pooled+analysis+from+the+pancreatic+cancer+cohort+consortium.&rft.au=Lynch%2C+Shannon+M%3BVrieling%2C+Alina%3BLubin%2C+Jay+H%3BKraft%2C+Peter%3BMendelsohn%2C+Julie+B%3BHartge%2C+Patricia%3BCanzian%2C+Federico%3BSteplowski%2C+Emily%3BArslan%2C+Alan+A%3BGross%2C+Myron%3BHelzlsouer%2C+Kathy%3BJacobs%2C+Eric+J%3BLaCroix%2C+Andrea%3BPetersen%2C+Gloria%3BZheng%2C+Wei%3BAlbanes%2C+Demetrius%3BAmundadottir%2C+Laufey%3BBingham%2C+Sheila+A%3BBoffetta%2C+Paolo%3BBoutron-Ruault%2C+Marie-Christine%3BChanock%2C+Stephen+J%3BClipp%2C+Sandra%3BHoover%2C+Robert+N%3BJacobs%2C+Kevin%3BJohnson%2C+Karen+C%3BKooperberg%2C+Charles%3BLuo%2C+Juhua%3BMessina%2C+Catherine%3BPalli%2C+Domenico%3BPatel%2C+Alpa+V%3BRiboli%2C+Elio%3BShu%2C+Xiao-Ou%3BRodriguez+Suarez%2C+Laudina%3BThomas%2C+Gilles%3BTj%C3%B8nneland%2C+Anne%3BTobias%2C+Geoffrey+S%3BTong%2C+Elissa%3BTrichopoulos%2C+Dimitrios%3BVirtamo%2C+Jarmo%3BYe%2C+Weimin%3BYu%2C+Kai%3BZeleniuch-Jacquette%2C+Anne%3BBueno-de-Mesquita%2C+H+Bas%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Lynch&rft.aufirst=Shannon&rft.date=2009-08-15&rft.volume=170&rft.issue=4&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwp134 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-11 N1 - Date created - 2009-07-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Stat Med. 2002 Jun 15;21(11):1539-58 [12111919] Cancer. 2002 May 1;94(9):2490-501 [12015775] Am J Epidemiol. 2003 Feb 15;157(4):335-44 [12578804] Public Health Nutr. 2002 Dec;5(6B):1113-24 [12639222] Am J Epidemiol. 1985 Nov;122(5):904-14 [4050778] Ann Epidemiol. 1994 Jan;4(1):1-10 [8205268] J Natl Cancer Inst. 1994 Oct 19;86(20):1510-6 [7932805] Cancer Epidemiol Biomarkers Prev. 1997 Jan;6(1):15-9 [8993792] Control Clin Trials. 1998 Feb;19(1):61-109 [9492970] J Natl Cancer Inst. 1999 Mar 17;91(6):535-41 [10088624] Br J Cancer. 1999 Aug;80(11):1830-7 [10468306] Br J Cancer. 2005 Jun 6;92(11):2076-83 [15886696] J Natl Cancer Inst. 2005 Oct 5;97(19):1407-27 [16204691] Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):517-23 [16537710] Lung Cancer. 2006 Sep;53(3):375-80 [16814423] Int J Cancer. 2007 May 1;120(9):1993-8 [17266034] Am J Epidemiol. 2007 Aug 15;166(4):479-89 [17548786] Epidemiology. 2007 Sep;18(5):639-48 [17700253] Br J Nutr. 2007 Nov;98(5):1006-13 [17524168] Clin Gastroenterol Hepatol. 2008 Mar;6(3):275-82 [18328435] Am J Epidemiol. 2008 Apr 15;167(8):970-5 [18250081] Langenbecks Arch Surg. 2008 Jul;393(4):535-45 [18193270] Arch Intern Med. 1996 Oct 28;156(19):2255-60 [8885826] Control Clin Trials. 2000 Dec;21(6 Suppl):251S-272S [11189683] J Natl Cancer Inst. 2002 Oct 2;94(19):1445-57 [12359854] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwp134 ER - TY - JOUR T1 - Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis. AN - 67522837; 19615953 AB - The process of drug metabolite identification is extremely important for drug efficacy, safety and pharmacokinetics. The traditional method usually involves using a drug with a radioactive labeled nuclei and/or isolating major drug metabolites by HPLC before applying MS and NMR analyses, which requires trained specialists to handle the radioactive compounds and is time consuming for offline-HPLC separation. A method using mass spectrometry-based metabonomics combined with multivariate statistical analysis was applied to rapidly identify metabolite profiles of tolcapone, a catechol-O-methyl transferase inhibitor for Parkinson's disease treatment. The tolcapone metabolites were identified based on the accurate mass measurement (<3 ppm) and MS(2) mass spectrum. In total, 16 tolcapone metabolites were detected and identified, 6 of which have not been reported previously. Our results indicate that the method has the capability to accelerate the process of identifying drug metabolites, ultimately reduce drug development costs, and make the process safer without requiring a drug with radioactive nuclei. Most importantly, the assay can detect the major and minor drug metabolites in a global view. Furthermore, since tolcapone has been associated with idiosyncratic drug induced liver toxicity the rapid detection of tolcapone-related metabolites can provide mechanistic toxicity information related to drug metabolism and the formation of reactive drug metabolites. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Sun, Jinchun AU - Von Tungeln, Linda S AU - Hines, Wade AU - Beger, Richard D AD - Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 2557 EP - 2565 VL - 877 IS - 24 KW - Benzophenones KW - 0 KW - Catechol O-Methyltransferase Inhibitors KW - Enzyme Inhibitors KW - Nitrophenols KW - tolcapone KW - CIF6334OLY KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Male KW - Female KW - Nitrophenols -- urine KW - Enzyme Inhibitors -- urine KW - Benzophenones -- urine KW - Chromatography, High Pressure Liquid -- methods KW - Mass Spectrometry -- methods KW - Metabolomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67522837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Identification+of+metabolite+profiles+of+the+catechol-O-methyl+transferase+inhibitor+tolcapone+in+rat+urine+using+LC%2FMS-based+metabonomics+analysis.&rft.au=Sun%2C+Jinchun%3BVon+Tungeln%2C+Linda+S%3BHines%2C+Wade%3BBeger%2C+Richard+D&rft.aulast=Sun&rft.aufirst=Jinchun&rft.date=2009-08-15&rft.volume=877&rft.issue=24&rft.spage=2557&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=1873-376X&rft_id=info:doi/10.1016%2Fj.jchromb.2009.06.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-24 N1 - Date created - 2009-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jchromb.2009.06.033 ER - TY - JOUR T1 - Pulmonary toxicity and kinetic study of Cy5.5-conjugated superparamagnetic iron oxide nanoparticles by optical imaging AN - 21070014; 10251566 AB - Recent advances in the development of nanotechnology and devices now make it possible to accurately deliver drugs or genes to the lung. Magnetic nanoparticles can be used as contrast agents, thermal therapy for cancer, and be made to concentrate to target sites through an external magnetic field. However, these advantages may also become problematic when taking into account safety and toxicological factors. This study demonstrated the pulmonary toxicity and kinetic profile of anti-biofouling polymer coated, Cy5.5-conjugated thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) by optical imaging. Negatively charged, 36 nm-sized, Cy5.5-conjugated TCL-SPION was prepared for optical imaging probe. Cy5.5-conjugated TCL-SPION was intratracheally instilled into the lung by a non-surgical method. Cy5.5-conjugated TCL-SPION slightly induced pulmonary inflammation. The instilled nanoparticles were distributed mainly in the lung and excreted in the urine via glomerular filtration. Urinary excretion was peaked at 3 h after instillation. No toxicity was found under the concentration of 1.8 mg/kg and the half-lives of nanoparticles in the lung and urine were estimated to be about 14.4+/-0.54 h and 24.7+/-1.02 h, respectively. Although further studies are required, our results showed that Cy5.5-conjugated TCL-SPION can be a good candidate for use in pulmonary delivery vehicles and diagnostic probes. JF - Toxicology and Applied Pharmacology AU - Cho, W S AU - Cho, M AU - Kim AU - Choi, M AU - Lee, J Y AU - Han, B S AU - Park, S N AU - Yu, M K AU - Jon, S AU - Jeong, J AD - Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung-ku, Seoul 122-704, Republic of Korea, wcho@staffmail.ed.ac.uk Y1 - 2009/08/15/ PY - 2009 DA - 2009 Aug 15 SP - 106 EP - 115 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 239 IS - 1 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - iron oxides KW - Probes KW - Contrast media KW - Drug development KW - Toxicity KW - imaging KW - Cancer KW - Inflammation KW - Magnetic fields KW - Filtration KW - Urine KW - Lung KW - Kinetics KW - Excretion KW - Polymers KW - Iron KW - nanoparticles KW - nanotechnology KW - X 24310:Pharmaceuticals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21070014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Pulmonary+toxicity+and+kinetic+study+of+Cy5.5-conjugated+superparamagnetic+iron+oxide+nanoparticles+by+optical+imaging&rft.au=Cho%2C+W+S%3BCho%2C+M%3BKim%3BChoi%2C+M%3BLee%2C+J+Y%3BHan%2C+B+S%3BPark%2C+S+N%3BYu%2C+M+K%3BJon%2C+S%3BJeong%2C+J&rft.aulast=Cho&rft.aufirst=W&rft.date=2009-08-15&rft.volume=239&rft.issue=1&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.05.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - iron oxides; Probes; Drug development; Toxicity; imaging; Cancer; Inflammation; Magnetic fields; Filtration; Lung; Urine; Kinetics; Contrast media; Excretion; nanoparticles; nanotechnology; Polymers; Iron DO - http://dx.doi.org/10.1016/j.taap.2009.05.026 ER - TY - JOUR T1 - Verocytotoxin-producing Escherichia coli O157 outbreak in Wrexham, North Wales, July 2009. AN - 733966009; 19679034 AB - An outbreak of Escherichia coli O157 involving four people in North Wales is currently being investigated. Laboratory typing shows all the isolates belong to phage type 2. All four cases reported eating different products from a fast food outlet in the area. The possibility of other common exposures is being explored. JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin AU - Hart, J AU - Smith, G AD - North Wales Health Protection Team, National Public Health Service for Wales, Mold, Flintshire, United Kingdom. Judy.Hart@nphs.wales.nhs.uk Y1 - 2009/08/13/ PY - 2009 DA - 2009 Aug 13 VL - 14 IS - 32 KW - Index Medicus KW - Young Adult KW - Humans KW - Adult KW - Food Contamination KW - Wales -- epidemiology KW - Female KW - Child, Preschool KW - Shiga-Toxigenic Escherichia coli -- isolation & purification KW - Escherichia coli Infections -- epidemiology KW - Escherichia coli O157 -- isolation & purification KW - Escherichia coli Infections -- diagnosis KW - Disease Outbreaks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733966009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Euro+surveillance+%3A+bulletin+Europeen+sur+les+maladies+transmissibles+%3D+European+communicable+disease+bulletin&rft.atitle=Verocytotoxin-producing+Escherichia+coli+O157+outbreak+in+Wrexham%2C+North+Wales%2C+July+2009.&rft.au=Hart%2C+J%3BSmith%2C+G&rft.aulast=Hart&rft.aufirst=J&rft.date=2009-08-13&rft.volume=14&rft.issue=32&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Euro+surveillance+%3A+bulletin+Europeen+sur+les+maladies+transmissibles+%3D+European+communicable+disease+bulletin&rft.issn=1560-7917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-07 N1 - Date created - 2009-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dental devices: classification of dental amalgam, reclassification of dental mercury, designation of special controls for dental amalgam, mercury, and amalgam alloy. Final rule. AN - 67559929; 19655469 AB - The Food and Drug Administration (FDA) is issuing a final rule classifying dental amalgam into class II, reclassifying dental mercury from class I to class II, and designating a special control to support the class II classifications of these two devices, as well as the current class II classification of amalgam alloy. The three devices are now classified in a single regulation. The special control for the devices is a guidance document entitled, "Class II Special Controls Guidance Document: Dental Amalgam, Mercury, and Amalgam Alloy." This action is being taken to establish sufficient regulatory controls to provide reasonable assurance of the safety and effectiveness of these devices. Elsewhere in this issue of the Federal Register, FDA is announcing the availability of the guidance document that will serve as the special control for the devices. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2009/08/04/ PY - 2009 DA - 2009 Aug 04 SP - 38685 EP - 38714 VL - 74 IS - 148 SN - 0097-6326, 0097-6326 KW - Dental Alloys KW - 0 KW - Gases KW - Mercury Compounds KW - Dental Amalgam KW - 8049-85-2 KW - Mercury KW - FXS1BY2PGL KW - Health technology assessment KW - United States KW - Environmental Monitoring -- legislation & jurisprudence KW - Animals KW - Environmental Pollution -- legislation & jurisprudence KW - Product Labeling -- legislation & jurisprudence KW - Breast Feeding KW - Humans KW - Child KW - Risk Assessment KW - Infant KW - Adult KW - Dental Restoration, Temporary KW - Adolescent KW - Male KW - Maternal Exposure -- adverse effects KW - Equipment Safety KW - Environmental Exposure -- legislation & jurisprudence KW - Infant, Newborn KW - Nervous System Diseases -- chemically induced KW - Occupational Exposure -- legislation & jurisprudence KW - Dental Restoration, Permanent KW - Child, Preschool KW - Pregnancy KW - Legislation, Dental KW - Kidney -- injuries KW - Female KW - Gases -- adverse effects KW - Mercury Compounds -- classification KW - Mercury -- classification KW - Milk, Human -- chemistry KW - Mercury -- urine KW - Mercury -- adverse effects KW - Dental Alloys -- classification KW - Dental Instruments -- adverse effects KW - Mercury Compounds -- adverse effects KW - Dental Alloys -- adverse effects KW - Dental Alloys -- toxicity KW - Dental Amalgam -- adverse effects KW - Dental Amalgam -- classification KW - Dental Instruments -- classification KW - Consumer Product Safety -- legislation & jurisprudence KW - Dental Amalgam -- toxicity KW - Mercury Compounds -- toxicity KW - Mercury -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67559929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Dental+devices%3A+classification+of+dental+amalgam%2C+reclassification+of+dental+mercury%2C+designation+of+special+controls+for+dental+amalgam%2C+mercury%2C+and+amalgam+alloy.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2009-08-04&rft.volume=74&rft.issue=148&rft.spage=38685&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-20 N1 - Date created - 2009-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of the general practitioner in testing for genital Chlamydia trachomatis infection: an analysis of enhanced surveillance data AN - 807273635; 13812210 AB - Background: To examine the relationship between genital chlamydia testing by healthcare providers and patient demographic characteristics in Tasmania, Australia, from 2001 to 2007. Methods: Analysis of enhanced surveillance data for genital Chlamydia trachomatis infections notified to the Tasmanian Communicable Diseases Prevention Unit between 1 January 2001 and 31 December 2007. Results: General practitioners identify most cases of genital chlamydia infection, irrespective of patient age, gender, indigenous status or urban status. Tests that are performed for screening purposes identify the largest number of cases in females, particularly in very young females. In males, tests performed due to the presence of clinical symptoms identify the majority of cases. However, tests performed for the purposes of contact tracing also identify a substantial burden of genital chlamydia infection, particularly in males. Conclusions: The present study demonstrates the critical role the general practitioner has in the identification of genital chlamydia infection. Opportunistic screening for genital chlamydia, including in the context of contact tracing, is an essential clinical activity that results in the identification of substantial numbers of cases of infection. Policy makers and public health practitioners should support general practice screening initiatives and remove the barriers to genital chlamydia screening in general practice. JF - Sexual Health AU - Shaw, Kelly AU - Stephens, Nicola AU - Coleman, David AU - O'Sullivan, Maree AD - Department of Health and Human Services, GPO Box 125, Hobart, Tas. 7000, Australia, kelly.shaw@dhhs.tas.gov.au Y1 - 2009/08/03/ PY - 2009 DA - 2009 Aug 03 SP - 208 EP - 212 PB - CSIRO Publishing, PO Box 1139 Collingwood Vic. 3066 Australia VL - 6 IS - 3 SN - 1448-5028, 1448-5028 KW - Microbiology Abstracts B: Bacteriology KW - Demography KW - Age KW - Data processing KW - Chlamydia trachomatis KW - Infection KW - Contact tracing KW - Public health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807273635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexual+Health&rft.atitle=Role+of+the+general+practitioner+in+testing+for+genital+Chlamydia+trachomatis+infection%3A+an+analysis+of+enhanced+surveillance+data&rft.au=Shaw%2C+Kelly%3BStephens%2C+Nicola%3BColeman%2C+David%3BO%27Sullivan%2C+Maree&rft.aulast=Shaw&rft.aufirst=Kelly&rft.date=2009-08-03&rft.volume=6&rft.issue=3&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Sexual+Health&rft.issn=14485028&rft_id=info:doi/10.1071%2FSH09010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Demography; Age; Data processing; Contact tracing; Infection; Public health; Chlamydia trachomatis DO - http://dx.doi.org/10.1071/SH09010 ER - TY - GEN T1 - Tribal CCDF Guide to "Financial Management, Grants Administration, and Program Accountability" AN - 881463787; ED519370 AB - Tribal managers and staff working with Federal grants must be fully knowledgeable of all applicable Federal requirements and skilled in applying these requirements to the daily operation of their programs, whether starting a new program or striving to maintain a quality program which meets the intent of the enacting legislation. It is the responsibility of both the tribal fiscal and program managers to identify the regulations and other requirements that apply to the programs they administer. This Guide focuses on the fiscal administration and accountability issues related to the tribal Child Care and Development Fund (CCDF) program, including basic financial management and grants management principles. Footnotes in each section point to sources of additional information, including guidance documents disseminated by the Child Care Bureau and specific sections of the Federal regulations that govern the CCDF program. Tribal CCDF administrators and fiscal managers should always consult the regulations and current CCDF guidance for the most comprehensive and up-to-date information on the management of a tribal CCDF program. By adhering to applicable regulations and working towards increased operating efficiencies, Tribes have the opportunity to provide enhanced child care services that promote both school readiness for Indian children and economic self-sufficiency for Indian families. Web Sites for Documents Referenced in This Guide are appended. (Contains 37 footnotes.) Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 32 PB - Child Care Bureau. US Department of Health and Human Services, Administration for Children & Families, Office of Family Assistance, 370 L'Enfant Promenade SW 5th Floor East, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Elementary Secondary Education KW - Financial Support KW - Program Administration KW - Administrator Guides KW - Grants KW - Child Care KW - Accountability KW - Tribes KW - Federal Legislation KW - Money Management KW - Program Guides KW - American Indian Studies KW - Educational Policy KW - Administrative Principles KW - Guidance KW - Federal Regulation KW - American Indian Education KW - School Readiness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881463787?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Modeling solvent evaporation during the manufacture of controlled drug-release coatings and the impact on release kinetics AN - 869588820; 14820682 AB - To improve functionality and performance, controlled drug-release coatings comprised of drug and polymer are integrated with traditional medical devices, e.g., drug eluting stents. Depending on manufacturing conditions, these coatings can exhibit complex microstructures. Previously, a thermodynamically consistent model was developed for microstructure evolution in these systems to establish relationships between process variables, microstructure, and the subsequent release kinetics. Calculations based on the model were, in general, consistent with experimental findings. However, because of assumptions regarding the evaporation of solvent during fabrication, the model was unable to capture variations through the coating thickness that are observed experimentally. Here, a straightforward method is introduced to incorporate solvent evaporation explicitly into the model. Calculations are used to probe the impact of solvent evaporation rate and drug loading on the microstructure that forms during manufacturing and subsequent drug release kinetics. The predicted structures and release kinetics are found to be consistent with experimental observations. Further, the calculations demonstrate that solvent evaporation rate can be as critical to device performance as the amount of drug within the coating. For example, changes of a factor of five in the amount of drug released were observed by modifying the rate of solvent evaporation during manufacturing. JF - Journal of Biomedical Materials Research, Part B: Applied Biomaterials AU - Kim, Chang-Soo AU - Saylor, David M AU - McDermott, Martin K AU - Patwardhan, Dinesh V AU - Warren, James A AD - Division of Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Device and Radiological Health, Food and Drug Administration, Silver Spring, Maryland 20903, chang-soo.kim@fda.hhs.gov Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - 688 EP - 699 PB - John Wiley & Sons, Inc. VL - 90B IS - 2 SN - 1552-4981, 1552-4981 KW - Biotechnology and Bioengineering Abstracts KW - drug delivery/release KW - stents KW - microstructure KW - computer modeling KW - simulation KW - controlled release KW - Drug delivery KW - Evaporation KW - Kinetics KW - Implants KW - Solvents KW - Probes KW - Drugs KW - Coatings KW - Models KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869588820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.atitle=Modeling+solvent+evaporation+during+the+manufacture+of+controlled+drug-release+coatings+and+the+impact+on+release+kinetics&rft.au=Kim%2C+Chang-Soo%3BSaylor%2C+David+M%3BMcDermott%2C+Martin+K%3BPatwardhan%2C+Dinesh+V%3BWarren%2C+James+A&rft.aulast=Kim&rft.aufirst=Chang-Soo&rft.date=2009-08-01&rft.volume=90B&rft.issue=2&rft.spage=688&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.issn=15524981&rft_id=info:doi/10.1002%2Fjbm.b.31336 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Drug delivery; Evaporation; Implants; Kinetics; Probes; Solvents; Drugs; Models; Coatings DO - http://dx.doi.org/10.1002/jbm.b.31336 ER - TY - JOUR T1 - High Performance and Acceptability of Self-Collected Rectal Swabs for Diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae in Men Who Have Sex With Men and Women AN - 754899954; 13552882 AB - Background: Identification of sexually transmitted infections (STI) is limited by the infrequent assessment of rectal STI. This study assesses usability of self-collected rectal swabs (SRS) in diagnosing rectal Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). Methods: In 2006 to 2007, clients of the Amsterdam and South Limburg STI outpatient clinics reporting receptive anal intercourse were asked to fill out a questionnaire and provide SRS. A standard provider-collected rectal swab (PRS) was also taken, and both were tested for CT and NG by a nucleic acid amplification tests. SRS performance was compared with PRS as to agreement, sensitivity, and specificity. Results: Prevalence of rectal CT was 11% among the 1458 MSM and 9% among the 936 women. Rectal NG prevalence was 7% and 2%. In 98% of both MSM and women, SRS and PRS yielded concordant CT test results, for NG agreement was 98% for MSM and 99.4% for women. SRS performance for CT and NG diagnosis was good in both groups and was comparable for both study regions. Slightly more (57% of MSM, 62% of women) preferred SRS to PRS or had no preference; 97% would visit the STI clinic again if SRS was standard practice. Conclusions: Because anal sex is a common practice for MSM and women, and anal STI are frequently present, rectal screening should be an essential part of an STI consultation. SRS is a feasible, valid, and acceptable alternative for MSM and women attending STI clinics, and hence should be considered for other settings as well. JF - Sexually Transmitted Diseases AU - van der Helm, JJ AU - Hoebe, CJPA AU - van Rooijen, MS AU - Brouwers, EEHG AU - Fennema, HSA AU - Thiesbrummel, HFJ AU - Dukers-Muijrers, NHTM AD - Cluster Infectious Diseases, Amsterdam Public Health Service, Weesperplein 1, 1018 WZ Amsterdam, The Netherlands, jvdhelm@ggd.amsterdam.nl Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 493 EP - 497 VL - 36 IS - 8 SN - 0148-5717, 0148-5717 KW - Microbiology Abstracts B: Bacteriology KW - Inventories KW - Rectum KW - anal sex KW - nucleic acids KW - Sexually-transmitted diseases KW - Chlamydia trachomatis KW - Infection KW - Neisseria gonorrhoeae KW - Sex KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754899954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Diseases&rft.atitle=High+Performance+and+Acceptability+of+Self-Collected+Rectal+Swabs+for+Diagnosis+of+Chlamydia+trachomatis+and+Neisseria+gonorrhoeae+in+Men+Who+Have+Sex+With+Men+and+Women&rft.au=van+der+Helm%2C+JJ%3BHoebe%2C+CJPA%3Bvan+Rooijen%2C+MS%3BBrouwers%2C+EEHG%3BFennema%2C+HSA%3BThiesbrummel%2C+HFJ%3BDukers-Muijrers%2C+NHTM&rft.aulast=van+der+Helm&rft.aufirst=JJ&rft.date=2009-08-01&rft.volume=36&rft.issue=8&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Diseases&rft.issn=01485717&rft_id=info:doi/10.1097%2FOLQ.0b013e3181a44b8c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Inventories; nucleic acids; anal sex; Rectum; Sexually-transmitted diseases; Infection; Sex; Chlamydia trachomatis; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1097/OLQ.0b013e3181a44b8c ER - TY - JOUR T1 - Detection of intracellular ADAMTS13, a secreted zinc-metalloprotease, via flow cytometry AN - 745642361; 13157796 AB - ADAMTS13 is a secreted metalloprotease that cleaves von Willebrand Factor multimers in order to maintain proper homeostasis. A severe deficiency in ADAMTS13 triggers a disorder known as thrombotic thrombocytopenic purpura. At present, ADAMTS13 expression levels are determined by immunoblotting. We established a flow cytometry methodology to detect intracellular ADAMTS13 in liver and kidney cells using a polyclonal antibody, BL154G, and several monoclonal antibodies previously used to detect ADAMTS13 by immunoblotting. The results were validated using confocal microscopy, immunoblotting, and an activity assay (FRETS-VWF73). We show that labeling ADAMTS13 with specific antibodies and detection by flow cytometry yields results that are comparable with previously established methods for ADAMTS13 detection. Specifically, we compared the endogenous expression levels of ADAMTS13 in various liver cell lines using flow cytometry and obtained results that parallel immunoblot analysis. Knockdown of ADAMTS13 expression via targeted siRNA resulted in significantly reduced median signal, displaying the sensitivity of this detection method. A further analysis of reliability and specificity was achieved through plasmid DNA and transfection reagent dose response studies. The flow cytometry method described here is useful in determining the expression of both endogenous and recombinant forms of intracellular ADAMTS13. Flow cytometry is a convenient, efficient, and cost-effective way to measure the expression levels of ADAMTS13. Published 2009 Wiley-Liss, Inc. JF - Cytometry Part A AU - Geetha, S AU - Allen, Courtni E AU - Hunt, Ryan C AU - Plum, Elizabeth AU - Garfield, Susan AU - Friedman, Scott L AU - Soejima, Kenji AU - Sauna, Zuben E AU - Kimchi-Sarfaty, Chava AD - Division of Hematology, Laboratory of Hemostasis, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda 20892, Maryland, chava.kimchi-sarfaty@fda.hhs.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 675 EP - 681 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 75A IS - 8 SN - 1552-4922, 1552-4922 KW - Biotechnology and Bioengineering Abstracts KW - Immunoblotting KW - Von Willebrand factor KW - Monoclonal antibodies KW - Hepatocytes KW - Homeostasis KW - Plasmids KW - Metalloproteinase KW - Flow cytometry KW - Antibodies KW - siRNA KW - Transfection KW - Confocal microscopy KW - Thrombotic thrombocytopenic purpura KW - Kidney KW - DNA KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745642361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Detection+of+intracellular+ADAMTS13%2C+a+secreted+zinc-metalloprotease%2C+via+flow+cytometry&rft.au=Geetha%2C+S%3BAllen%2C+Courtni+E%3BHunt%2C+Ryan+C%3BPlum%2C+Elizabeth%3BGarfield%2C+Susan%3BFriedman%2C+Scott+L%3BSoejima%2C+Kenji%3BSauna%2C+Zuben+E%3BKimchi-Sarfaty%2C+Chava&rft.aulast=Geetha&rft.aufirst=S&rft.date=2009-08-01&rft.volume=75A&rft.issue=8&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524922&rft_id=info:doi/10.1002%2Fcyto.a.20748 L2 - http://www3.interscience.wiley.com/journal/122456537/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Immunoblotting; Von Willebrand factor; Hepatocytes; Monoclonal antibodies; Homeostasis; Plasmids; Flow cytometry; Metalloproteinase; Antibodies; siRNA; Transfection; Thrombotic thrombocytopenic purpura; Confocal microscopy; DNA; Kidney DO - http://dx.doi.org/10.1002/cyto.a.20748 ER - TY - JOUR T1 - Frictional ignitions in underground bituminous coal operations 1983 to 2005 AN - 742927265; 2010-063910 AB - A statistical study of available data regarding frictional ignitions in the United States from 1983 to 2005 was conducted by the National Institute for Occupational Safety and Health (NIOSH) to determine and define conditions controlling their occurrence (MSHA, 2006a; MSHA, 2006b; and MSHA, 2006c). Frictional ignitions are defined as the ignition of a flammable mixture of methane and air that is initiated by frictional heating. Ignitions created through the addition of energy from open flames and exposed electrical circuits are not included in this analysis. Energy released in a roof fall that creates a spark and ignites a methane mixture would be considered a frictional ignition. Frictional ignitions represent the majority of all ignitions in underground coal mines. Over the study period of 1983 to 2005, a total of 1,993 ignitions were reported in underground bituminous coal mines in the United States, of which 1,589 were frictional ignitions. Reportable ignitions to the U.S. Mine Safety and Health Administration (MSHA) are any unintentional occurrences of flame underground regardless of duration. Continuous miners represented the largest source for frictional ignitions with 1,090 (68.6% of all frictional ignitions). Longwall mining operations represented the highest concentration of frictional ignitions during this study period with 1,365 frictional ignitions (85.9% of all frictional ignitions). From 1983 to 1991, underground productivity and the number of frictional ignitions increased. However, productivity continued to increase from 1991 to 2000 while total frictional ignitions fell, thereby disproving this connection between productivity and frequency of frictional ignitions. Ninety percent of all frictional ignitions occurred in underground coal mines that liberated more than 393 L/s (1.2 MMcfd million cubic feet per day) of methane through the main ventilation system. Although methane production is not the determining factor for the occurrence of frictional ignitions, it is a good indicator of the anticipated frequency. JF - Mining Engineering AU - Krog, R B AU - Schatzel, S J Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 28 EP - 35 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO VL - 61 IS - 8 SN - 0026-5187, 0026-5187 KW - mining legislation KW - mining KW - methane KW - geologic hazards KW - underground mining KW - statistical analysis KW - aliphatic hydrocarbons KW - sandstone KW - coal seams KW - alkanes KW - organic compounds KW - sedimentary rocks KW - safety KW - rock bursts KW - mining geology KW - hydrocarbons KW - clastic rocks KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742927265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mining+Engineering&rft.atitle=Frictional+ignitions+in+underground+bituminous+coal+operations+1983+to+2005&rft.au=Krog%2C+R+B%3BSchatzel%2C+S+J&rft.aulast=Krog&rft.aufirst=R&rft.date=2009-08-01&rft.volume=61&rft.issue=8&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Mining+Engineering&rft.issn=00265187&rft_id=info:doi/ L2 - http://me.smenet.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 6 N1 - PubXState - CO N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - CODEN - MIENAB N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; clastic rocks; coal seams; geologic hazards; hydrocarbons; methane; mining; mining geology; mining legislation; organic compounds; rock bursts; safety; sandstone; sedimentary rocks; statistical analysis; underground mining ER - TY - JOUR T1 - Sodium phosphate tablets and acute phosphate nephropathy. AN - 742785034; pmid-19661931 JF - The American journal of gastroenterology AU - Mackey, Ann Corken AU - Green, Lanh AU - Amand, Keith St AU - Avigan, Mark AD - Office of Surveillance and Epidemiology, Food and Drug Administration, Building 22, Room 3472, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA. ann.mackey@fda.hhs.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1903 EP - 1906 VL - 104 IS - 8 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Phosphates -- metabolism KW - Acute Disease KW - Humans KW - Adult KW - Tablets KW - Aged KW - Phosphates -- adverse effects KW - Middle Aged KW - Female KW - Male KW - Kidney Diseases -- metabolism KW - Cathartics -- adverse effects KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742785034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Sodium+phosphate+tablets+and+acute+phosphate+nephropathy.&rft.au=Mackey%2C+Ann+Corken%3BGreen%2C+Lanh%3BAmand%2C+Keith+St%3BAvigan%2C+Mark&rft.aulast=Mackey&rft.aufirst=Ann&rft.date=2009-08-01&rft.volume=104&rft.issue=8&rft.spage=1903&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - SuppNotes - Comment In: Am J Gastroenterol. 2010 Mar;105(3):705[20203655]; Comment In: Am J Gastroenterol. 2010 Feb;105(2):476-7[20139888]; Comment In: Am J Gastroenterol. 2009 Aug;104(8):1907-9[19661932] N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Harness sizing and strap length configurations. AN - 734130640; 19899360 AB - OBJECTIVE This article describes the derivation of strap lengths and adjustments to fall-arrest harnesses and the development of harness size configurations. BACKGROUND Updated harness sizing configurations are needed to accommodate diverse populations in the current workforce. METHOD Three-dimensional torso anthropometric data from 243 women and 258 men were incorporated into eight validated equations to develop a cost-effective harness sizing plan and to define strap lengths. RESULTS To met strap adjustable range goals and to accommodate 95% to 98% of the estimated population, two sizing options were identified. CONCLUSION Study outcomes suggest system improvement with three to four sizes for women and three to four sizes for men, on which the adjustment ranges of the torso straps were within 15 to 17 cm and within 20 to 23 cm on thigh and hip straps. APPLICATION This research provided harness sizing and cut-length information for harness design to reduce the risk of worker injury that results from poor fit or improper size selection. JF - Human factors AU - Hsiao, Hongwei AU - Whitestone, Jennifer AU - Taylor, Stacie AU - Godby, Mary AU - Guan, Jinhua AD - Protective Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA. hhsiao@cdc.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 497 EP - 518 VL - 51 IS - 4 SN - 0018-7208, 0018-7208 KW - Index Medicus KW - Space life sciences KW - Humans KW - Male KW - Female KW - Body Size KW - Accidents, Occupational -- prevention & control KW - Human Engineering KW - Equipment Design KW - Accidental Falls -- prevention & control KW - Protective Devices -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734130640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+factors&rft.atitle=Harness+sizing+and+strap+length+configurations.&rft.au=Hsiao%2C+Hongwei%3BWhitestone%2C+Jennifer%3BTaylor%2C+Stacie%3BGodby%2C+Mary%3BGuan%2C+Jinhua&rft.aulast=Hsiao&rft.aufirst=Hongwei&rft.date=2009-08-01&rft.volume=51&rft.issue=4&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Human+factors&rft.issn=00187208&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-05 N1 - Date created - 2009-11-10 N1 - Date revised - 2017-02-15 N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Studies of acetaminophen and metabolites in urine and their correlations with toxicity using metabolomics. AN - 734073150; 19702550 AB - A LC/MS-based metabolomic assay was utilized to investigate a drug's excretion kinetic profile in urine so that the drug toxicity information could be obtained. Groups of 10 male Sprague-Dawley rats per dose were orally gavaged with a single dose of 0.2% carboxymethylcellulose, 400 mg acetaminophen (APAP)/kg body weight or 1600 mg APAP/kg. UPLC/MS and NMR were used to evaluate the excretion kinetics of major drug metabolites. N-acetyl-L-cysteine acetaminophen (APAP-NAC) had statistically significant correlations with clinical chemistry data, endogenous metabolite concentrations and histopathology data. The potential toxicity of a drug can be assessed through the study of the drug's metabolite profiles. JF - Drug metabolism letters AU - Sun, Jinchun AU - Schnackenberg, Laura K AU - Beger, Richard D AD - Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 130 EP - 136 VL - 3 IS - 3 KW - Analgesics, Non-Narcotic KW - 0 KW - Sulfates KW - Acetaminophen KW - 362O9ITL9D KW - S-Adenosylmethionine KW - 7LP2MPO46S KW - acetaminophen glucuronide KW - 8BE7G9R76X KW - Creatine KW - MU72812GK0 KW - Index Medicus KW - Administration, Oral KW - Animals KW - Mass Spectrometry KW - Dose-Response Relationship, Drug KW - Principal Component Analysis KW - Creatine -- urine KW - S-Adenosylmethionine -- urine KW - Magnetic Resonance Spectroscopy KW - Rats KW - Rats, Sprague-Dawley KW - Biotransformation KW - Chromatography, Liquid KW - Sulfates -- urine KW - Male KW - Metabolomics -- methods KW - Acetaminophen -- administration & dosage KW - Liver -- pathology KW - Acetaminophen -- pharmacokinetics KW - Analgesics, Non-Narcotic -- pharmacokinetics KW - Chemical and Drug Induced Liver Injury -- pathology KW - Liver -- metabolism KW - Acetaminophen -- analogs & derivatives KW - Acetaminophen -- urine KW - Analgesics, Non-Narcotic -- administration & dosage KW - Analgesics, Non-Narcotic -- urine KW - Chemical and Drug Induced Liver Injury -- etiology KW - Liver -- drug effects KW - Analgesics, Non-Narcotic -- toxicity KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734073150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+letters&rft.atitle=Studies+of+acetaminophen+and+metabolites+in+urine+and+their+correlations+with+toxicity+using+metabolomics.&rft.au=Sun%2C+Jinchun%3BSchnackenberg%2C+Laura+K%3BBeger%2C+Richard+D&rft.aulast=Sun&rft.aufirst=Jinchun&rft.date=2009-08-01&rft.volume=3&rft.issue=3&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+letters&rft.issn=1874-0758&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-11 N1 - Date created - 2009-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental health research and the observer's dilemma. AN - 67584317; 19672396 AB - Environmental health researchers frequently study people in occupational, educational, recreational, or domestic settings who are exposed to hazardous agents. Deciding whether-and how-to inform research subjects about risks they face in their environment can be a challenging task for investigators. Because legal rules and professional guidelines do not cover this topic, investigators must carefully consider their ethical obligations in light of the facts and circumstances. To navigate through this dilemma, investigators should consider the evidence for the risks, the nature of the risks, the usefulness of risk information to the subjects, and the effects on the study and community of informing subjects about risks. JF - Environmental health perspectives AU - Resnik, David B AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. resnikd@niehs.nih.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 1191 EP - 1194 VL - 117 IS - 8 KW - Index Medicus KW - risk KW - human subjects KW - beneficence KW - observation KW - ethics KW - regulations KW - risk communication KW - environmental health research KW - Humans KW - Environmental Exposure KW - Risk Assessment KW - Disclosure -- ethics KW - Environmental Health -- ethics KW - Ethics, Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67584317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Environmental+health+research+and+the+observer%27s+dilemma.&rft.au=Resnik%2C+David+B&rft.aulast=Resnik&rft.aufirst=David&rft.date=2009-08-01&rft.volume=117&rft.issue=8&rft.spage=1191&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0900861 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-20 N1 - Date created - 2009-08-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bioethics. 2008 May;22(4):209-17 [18405319] Environ Health Perspect. 2008 Apr;116(4):537-42 [18414640] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Jul-Sep;26(3):237-55 [18781537] Environ Sci Technol. 2008 Nov 15;42(22):8252-9 [19068802] BMC Cancer. 2008;8:387 [19108730] Ann Allergy Asthma Immunol. 2009 Feb;102(2):125-30 [19230463] Am J Public Health. 2007 Mar;97(3):414-8 [17267718] J Med Ethics. 2007 Aug;33(8):481-6 [17664310] JAMA. 2000 May 24-31;283(20):2701-11 [10819955] Am J Bioeth. 2002 Spring;2(2):3-9 [12189059] Hastings Cent Rep. 2004 Jan-Feb;34(1):25-33 [15098404] Mil Med. 2005 Jun;170(6):505-9 [16001601] Nature. 2009 Mar 12;458(7235):148 [19279615] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0900861 ER - TY - JOUR T1 - A reconsideration of acute Beryllium disease. AN - 67584293; 19672405 AB - Although chronic beryllium disease (CBD) is clearly an immune-mediated granulomatous reaction to beryllium, acute beryllium disease (ABD) is commonly considered an irritative chemical phenomenon related to high exposures. Given reported new cases of ABD and projected increased demand for beryllium, we aimed to reevaluate the patho physiologic associations between ABD and CBD using two cases identified from a survey of beryllium production facility workers. Within weeks after exposure to beryllium fluoride began, two workers had systemic illness characterized by dermal and respiratory symptoms and precipitous declines in pulmonary function. Symptoms and pulmonary function abnormalities improved with cessation of exposure and, in one worker, recurred with repeat exposure. Bronchoalveolar lavage fluid analyses and blood beryllium lymphocyte proliferation tests revealed lymphocytic alveolitis and cellular immune recognition of beryllium. None of the measured air samples exceeded 100 microg/m(3), and most were < 10 microg/m(3), lower than usually described. In both cases, lung biopsy about 18 months after acute illness revealed noncaseating granulomas. Years after first exposure, the workers left employment because of CBD. Contrary to common understanding, these cases suggest that ABD and CBD represent a continuum of disease, and both involve hypersensitivity reactions to beryllium. Differences in disease presentation and progression are likely influenced by the solubility of the beryllium compound involved. ABD may occur after exposures lower than the high concentrations commonly described. Prudence dictates limitation of further beryllium exposure in both ABD and CBD. JF - Environmental health perspectives AU - Cummings, Kristin J AU - Stefaniak, Aleksandr B AU - Virji, M Abbas AU - Kreiss, Kathleen AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. cvx5@cdc.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 1250 EP - 1256 VL - 117 IS - 8 KW - Air Pollutants, Occupational KW - 0 KW - Radioactive Pollutants KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - pneumonitis KW - hypersensitivity KW - immune sensitization KW - granuloma KW - beryllium disease KW - beryllium KW - acute KW - Young Adult KW - Hypersensitivity -- immunology KW - Skin -- drug effects KW - Humans KW - Adult KW - Air Pollutants, Occupational -- immunology KW - Male KW - Berylliosis -- immunology KW - Berylliosis -- etiology KW - Beryllium -- immunology KW - Radioactive Pollutants -- toxicity KW - Respiratory System -- pathology KW - Berylliosis -- pathology KW - Respiratory System -- drug effects KW - Beryllium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67584293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=A+reconsideration+of+acute+Beryllium+disease.&rft.au=Cummings%2C+Kristin+J%3BStefaniak%2C+Aleksandr+B%3BVirji%2C+M+Abbas%3BKreiss%2C+Kathleen&rft.aulast=Cummings&rft.aufirst=Kristin&rft.date=2009-08-01&rft.volume=117&rft.issue=8&rft.spage=1250&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0800455 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-20 N1 - Date created - 2009-08-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Invest Dermatol. 2000 Aug;115(2):168-76 [10951232] J Am Med Assoc. 1945 Dec 15;129:1084-90 [21004768] Appl Occup Environ Hyg. 2001 May;16(5):539-58 [11370934] Int Immunopharmacol. 2002 Feb;2(2-3):249-61 [11811929] Clin Exp Dermatol. 2002 Mar;27(2):138-46 [11952708] AIHA J (Fairfax, Va). 2003 May-Jun;64(3):297-305 [12809534] Chem Res Toxicol. 2003 Sep;16(9):1145-54 [12971803] Mod Pathol. 2003 Nov;16(11):1171-7 [14614058] J Environ Monit. 2004 Jun;6(6):523-32 [15173904] Am J Ind Med. 2004 Aug;46(2):95-103 [15273960] N Engl J Med. 1965 Nov 25;273(22):1188-99 [5847559] Hum Pathol. 1970 Mar;1(1):25-44 [5521721] J Soc Occup Med. 1977 Jul;27(3):93-6 [895082] Br J Dis Chest. 1979 Apr;73(2):192-4 [394757] Environ Res. 1982 Feb;27(1):79-88 [7040071] Postgrad Med J. 1988 Jul;64(753):511-6 [3074283] Sarcoidosis. 1989 Sep;6(2):111-7 [2602683] J Allergy Clin Immunol. 1991 Jul;88(1):54-60 [2071785] Clin Immunol Immunopathol. 1994 May;71(2):123-9 [8181181] Occup Environ Med. 1997 Aug;54(8):605-12 [9326165] Proc R Soc Med. 1951 Mar;44(3):257-62 [14834212] AMA Arch Ind Hyg Occup Med. 1951 Aug;4(2):123-51 [14856439] AMA Arch Ind Health. 1959 Feb;19(2):110-6 [13616728] AMA Arch Ind Health. 1959 Feb;19(2):150-3 [13616733] AMA Arch Ind Health. 1959 Feb;19(2):154-6 [13616734] AMA Arch Ind Health. 1959 Feb;19(2):179-83 [13616739] Am J Respir Crit Care Med. 2005 Jan 1;171(1):54-60 [15374840] Exp Lung Res. 2005 Apr;31(3):341-60 [15962713] J Occup Environ Med. 2005 Dec;47(12):1218-26 [16340702] Toxicol In Vitro. 2006 Feb;20(1):82-95 [16061346] Am J Ind Med. 2006 Jan;49(1):36-44 [16362939] J Allergy Clin Immunol. 2006 Aug;118(2):441-6 [16890770] Int J Dermatol. 2006 Oct;45(10):1240-2 [17040452] Clin Immunol. 2006 Nov;121(2):134-43 [16697706] Annu Rev Public Health. 2007;28:259-77 [17094767] Inhal Toxicol. 2007;19 Suppl 1:117-26 [17886059] Inhal Toxicol. 2007;19 Suppl 1:241-4 [17886072] Semin Respir Crit Care Med. 2007 Oct;28(5):504-13 [17975778] Chem Commun (Camb). 2008 Jul 7;(25):2837-47 [18566702] J Toxicol Environ Health A. 2008;71(22):1468-81 [18836922] Am J Pathol. 1948 Nov;24(6):1137-65 [18894821] Appl Occup Environ Hyg. 2001 May;16(5):514-20 [11370931] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0800455 ER - TY - JOUR T1 - Essential features for proactive risk management. AN - 67560611; 19661998 AB - We propose a proactive approach to the management of occupational health risks in emerging technologies based on six features: qualitative risk assessment; the ability to adapt strategies and refine requirements; an appropriate level of precaution; global applicability; the ability to elicit voluntary cooperation by companies; and stakeholder involvement. JF - Nature nanotechnology AU - Murashov, Vladimir AU - Howard, John AD - National Institute for Occupational Safety and Health, US Department of Health and Human Services, Washington, DC 20201, USA. vladimir.murashov@cdc.hhs.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 467 EP - 470 VL - 4 IS - 8 KW - Index Medicus KW - International Cooperation KW - Humans KW - Voluntary Programs KW - Technology KW - Industry KW - Occupational Health KW - Risk Management -- methods KW - Occupational Exposure -- prevention & control KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67560611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+nanotechnology&rft.atitle=Essential+features+for+proactive+risk+management.&rft.au=Murashov%2C+Vladimir%3BHoward%2C+John&rft.aulast=Murashov&rft.aufirst=Vladimir&rft.date=2009-08-01&rft.volume=4&rft.issue=8&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Nature+nanotechnology&rft.issn=1748-3395&rft_id=info:doi/10.1038%2Fnnano.2009.205 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-05 N1 - Date created - 2009-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nnano.2009.205 ER - TY - JOUR T1 - The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer. AN - 67558703; 19493248 AB - Telomeres consist of nucleotide repeats and a protein complex at chromosome ends that are essential to maintaining chromosomal integrity. Several studies have suggested that subjects with shorter telomeres are at increased risk of bladder and lung cancer. In comparison to normal tissues, telomeres are shorter in high-grade intraepithelial neoplasia and prostate cancer. We examined prostate cancer risk associated with relative telomere length as determined by quantitative PCR on prediagnostic buffy coat DNA isolated from 612 advanced prostate cancer cases and 1049 age-matched, cancer-free controls from the PLCO Cancer Screening Trial. Telomere length was analyzed as both a continuous and a categorical variable with adjustment for potential confounders. Statistically significant inverse correlations between telomere length, age and smoking status were observed in cases and controls. Telomere length was not associated with prostate cancer risk (at the median, OR = 0.85, 95% CI: 0.67, 1.08); associations were similar when telomere length was evaluated as a continuous variable or by quartiles. The relationships between telomere length and inflammation-related factors, diet, exercise, body mass index, and other lifestyle variables were explored since many of these have previously been associated with shorter telomeres. Healthy lifestyle factors (i.e., lower BMI, more exercise, tobacco abstinence, diets high in fruit and vegetables) tended to be associated with greater telomere length. This study found no statistically significant association between leukocyte telomere length and advanced prostate cancer risk. However, correlations of telomere length with healthy lifestyles were noted, suggesting the role of these factors in telomere biology maintenance and potentially impacting overall health status. JF - Aging cell AU - Mirabello, Lisa AU - Huang, Wen-Yi AU - Wong, Jason Y Y AU - Chatterjee, Nilanjan AU - Reding, Douglas AU - Crawford, E David AU - De Vivo, Immaculata AU - Hayes, Richard B AU - Savage, Sharon A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 405 EP - 413 VL - 8 IS - 4 KW - Index Medicus KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Life Style KW - Prostatic Neoplasms -- epidemiology KW - Telomere KW - Leukocytes KW - Prostatic Neoplasms -- chemically induced KW - Smoking -- adverse effects KW - Prostatic Neoplasms -- genetics KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67558703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+cell&rft.atitle=The+association+between+leukocyte+telomere+length+and+cigarette+smoking%2C+dietary+and+physical+variables%2C+and+risk+of+prostate+cancer.&rft.au=Mirabello%2C+Lisa%3BHuang%2C+Wen-Yi%3BWong%2C+Jason+Y+Y%3BChatterjee%2C+Nilanjan%3BReding%2C+Douglas%3BCrawford%2C+E+David%3BDe+Vivo%2C+Immaculata%3BHayes%2C+Richard+B%3BSavage%2C+Sharon+A&rft.aulast=Mirabello&rft.aufirst=Lisa&rft.date=2009-08-01&rft.volume=8&rft.issue=4&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Aging+cell&rft.issn=1474-9726&rft_id=info:doi/10.1111%2Fj.1474-9726.2009.00485.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-26 N1 - Date created - 2009-08-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2002 May 15;30(10):e47 [12000852] Trends Biochem Sci. 2002 Jul;27(7):339-44 [12114022] Am J Epidemiol. 2002 Aug 1;156(3):274-85 [12142263] Science. 2002 Jul 26;297(5581):565-9 [12142527] Diabetes Care. 2006 Feb;29(2):283-9 [16443874] Epidemiology. 2006 Mar;17(2):190-4 [16477260] Cytogenet Genome Res. 2006;112(3-4):194-201 [16484772] Eur Respir J. 2006 Mar;27(3):525-8 [16507852] Int J Cancer. 2006 Oct 1;119(7):1690-4 [16646073] Neurosci Lett. 2006 Oct 9;406(3):260-4 [16919874] Aging Cell. 2006 Oct;5(5):361-5 [16856882] Neoplasia. 2007 Jan;9(1):81-9 [17325746] J Urol. 2007 Apr;177(4):1395-400; quiz 1591 [17382740] Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):815-9 [17416776] Nat Genet. 2007 May;39(5):645-9 [17401363] Front Biosci. 2007;12:4595-620 [17485399] Indian J Med Res. 2007 Mar;125(3):441-50 [17496367] Cancer Res. 2007 Jun 1;67(11):5538-44 [17545637] Chronic Dis Can. 2007;27(4):145-53 [17623560] J Urol. 2007 Oct;178(4 Pt 1):1492-6 [17707063] Aging Cell. 2007 Oct;6(5):639-47 [17874998] Am J Clin Nutr. 2007 Nov;86(5):1420-5 [17991655] Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2649-55 [18086770] Free Radic Biol Med. 2008 Feb 1;44(3):235-46 [18021748] Arch Intern Med. 2008 Jan 28;168(2):154-8 [18227361] Mov Disord. 2008 Jan 30;23(2):302-5 [18044760] J Hum Hypertens. 2008 Mar;22(3):230-2 [18046431] Nat Genet. 2008 Mar;40(3):310-5 [18264096] Nat Genet. 2008 Mar;40(3):316-21 [18264097] Circulation. 2008 Mar 4;117(9):1138-44 [18268147] Physiol Rev. 2008 Apr;88(2):557-79 [18391173] Cancer Res. 2008 May 15;68(10):3618-23 [18483243] Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1165-71 [18388332] Cancer Sci. 2008 Jul;99(7):1385-9 [18452563] J Natl Cancer Inst. 2008 Jun 4;100(11):796-804 [18505967] Acta Paediatr. 2008 Jul;97(7):952-4 [18430074] Mutat Res. 2008 Jul-Aug;659(1-2):15-30 [18485806] Curr Urol Rep. 2008 May;9(3):243-9 [18765120] Toxicology. 2002 Nov 15;180(2):121-37 [12324189] Cancer Res. 2002 Nov 15;62(22):6405-9 [12438224] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Hum Mol Genet. 2003 Feb 1;12(3):227-32 [12554677] Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):434-9 [12615693] J Natl Cancer Inst. 2003 Aug 20;95(16):1211-8 [12928346] Lancet. 2003 Sep 20;362(9388):983-8 [14511933] Lancet. 2004 Feb 14;363(9408):507-10 [14975611] Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R103-21 [14749351] Circ Res. 2004 Mar 19;94(5):575-84 [15031270] Oncogene. 2004 Apr 12;23(16):2919-33 [15077154] Eur J Cancer. 1997 Apr;33(5):787-91 [9282118] Cell. 1997 Oct 3;91(1):25-34 [9335332] Diabetes. 1998 Mar;47(3):482-6 [9519758] Cell. 1999 Mar 5;96(5):701-12 [10089885] J Urol. 1999 Nov;162(5):1788-92 [10524936] J Urol. 2005 Feb;173(2):610-4 [15643274] Int J Biochem Cell Biol. 2005 May;37(5):1000-13 [15743674] Circulation. 2005 May 3;111(17):2171-7 [15851602] Carcinogenesis. 2005 Jul;26(7):1263-71 [15746160] Lancet. 2005 Aug 20-26;366(9486):662-4 [16112303] Future Oncol. 2008 Oct;4(5):637-45 [18922121] Lancet Oncol. 2008 Nov;9(11):1048-57 [18799354] Am J Epidemiol. 2009 Feb 1;169(3):323-9 [19056834] Genes Dev. 2005 Sep 15;19(18):2100-10 [16166375] Exp Cell Res. 2000 May 1;256(2):578-82 [10772830] Nature. 2000 Aug 10;406(6796):641-5 [10949306] Control Clin Trials. 2000 Dec;21(6 Suppl):251S-272S [11189683] Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684] Oncogene. 2002 Jan 21;21(4):564-79 [11850781] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1474-9726.2009.00485.x ER - TY - JOUR T1 - Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine. AN - 67537017; 19535489 AB - The present study compared the immunolocalization of Kim-1, renal papillary antigen (RPA)-1, and RPA-2 with that of inducible nitric oxide synthase (iNOS) and nitrotyrosine in kidneys of gentamicin sulfate (Gen)- and cisplatin (Cis)-treated rats. The specificity of acute kidney injury (AKI) biomarkers, iNOS, and nitrotyrosine was evaluated by dosing rats with valproic acid (VPA). Sprague-Dawley (SD) rats were injected subcutaneously (sc) with 100 mg/kg/day of Gen for six or fourteen days; a single intraperitoneal (ip) dose of 1, 3, or 6 mg/kg of Cis; or 650 mg/kg/day of VPA (ip) for four days. In Gen-treated rats, Kim-1 was expressed in the epithelial cells, mainly in the S1/S2 segments but less so in the S3 segment, and RPA-1 was increased in the epithelial cells of collecting ducts (CD) in the cortex. Spatial expression of iNOS or nitrotyrosine with Kim-1 or RPA-1 was detected. In Cis-treated rats, Kim-1 was expressed only in the S3 segment cells, and RPA-1 and RPA-2 were increased in the epithelial cells of medullary CD or medullary loop of Henle (LH), respectively. Spatial expression of iNOS or nitrotyrosine with RPA-1 or RPA-2 was also identified. These findings suggest that peroxynitrite formation may be involved in the pathogenesis of Gen and Cis nephrotoxicity and that Kim-1, RPA-1, and RPA-2 have the potential to serve as site-specific biomarkers for Gen or Cis AKI. JF - Toxicologic pathology AU - Zhang, Jun AU - Goering, Peter L AU - Espandiari, Parvaneh AU - Shaw, Martin AU - Bonventre, Joseph V AU - Vaidya, Vishal S AU - Brown, Ronald P AU - Keenan, Joe AU - Kilty, Cormac G AU - Sadrieh, Nakissa AU - Hanig, Joseph P AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. jun.zhang@fda.hhs.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 629 EP - 643 VL - 37 IS - 5 KW - Antigens KW - 0 KW - Cell Adhesion Molecules KW - Gentamicins KW - Havcr1protein, rat KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Valproic Acid KW - 614OI1Z5WI KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Nos2 protein, rat KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - Kidney -- pathology KW - Kidney -- drug effects KW - Rats KW - Kidney Diseases -- metabolism KW - Rats, Sprague-Dawley KW - Photomicrography KW - Kidney Tubules, Proximal -- metabolism KW - Kidney Tubules, Proximal -- drug effects KW - Immunohistochemistry KW - Statistics, Nonparametric KW - Male KW - Kidney Diseases -- chemically induced KW - Valproic Acid -- pharmacology KW - Antigens -- metabolism KW - Tyrosine -- biosynthesis KW - Cisplatin -- pharmacology KW - Cell Adhesion Molecules -- metabolism KW - Nitric Oxide Synthase Type II -- metabolism KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives KW - Nitric Oxide Synthase Type II -- biosynthesis KW - Gentamicins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67537017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Differences+in+immunolocalization+of+Kim-1%2C+RPA-1%2C+and+RPA-2+in+kidneys+of+gentamicin-%2C+cisplatin-%2C+and+valproic+acid-treated+rats%3A+potential+role+of+iNOS+and+nitrotyrosine.&rft.au=Zhang%2C+Jun%3BGoering%2C+Peter+L%3BEspandiari%2C+Parvaneh%3BShaw%2C+Martin%3BBonventre%2C+Joseph+V%3BVaidya%2C+Vishal+S%3BBrown%2C+Ronald+P%3BKeenan%2C+Joe%3BKilty%2C+Cormac+G%3BSadrieh%2C+Nakissa%3BHanig%2C+Joseph+P&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2009-08-01&rft.volume=37&rft.issue=5&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623309339605 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-29 N1 - Date created - 2009-07-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Lett. 2008 Jan 4;176(1):48-57 [18063323] Toxicol Sci. 2008 Jan;101(1):159-70 [17934191] Toxicol Pathol. 2008 Apr;36(3):397-409 [18441258] J Appl Toxicol. 2008 Jul;28(5):628-37 [17994530] Kidney Int. 2000 Aug;58(2):658-73 [10916089] J Pharmacol Exp Ther. 2000 Oct;295(1):417-22 [10992009] Kidney Int. 2002 Mar;61(3):862-71 [11849439] Kidney Int. 2002 Oct;62(4):1249-63 [12234295] Kidney Int. 2003 Mar;63(3):853-65 [12631066] Environ Health Perspect. 2004 Mar;112(4):465-79 [15033597] BMC Clin Pharmacol. 2004 Apr 30;4:5 [15119956] J Ultrastruct Res. 1966 Jun;15(3):242-82 [5328614] J Ultrastruct Res. 1966 Jun;15(3):283-309 [5328615] J Ultrastruct Res. 1966 Oct;16(3):239-58 [5333381] Ren Physiol. 1987;10(1):54-64 [3685614] Dan Med Bull. 1990 Feb;37(1):1-12 [2178884] Arch Toxicol. 1996;71(1-2):80-92 [9010589] Ren Fail. 1997 Nov;19(6):723-43 [9415930] Arch Toxicol. 1999 Jun-Jul;73(4-5):233-45 [10463389] Toxicol Pathol. 1999 Jul-Aug;27(4):427-35 [10485823] BMC Pharmacol. 2004 Sep 30;4:20 [15458572] Toxicology. 2005 Mar 15;208(2):273-88 [15691591] J Pharmacol Sci. 2005 Sep;99(1):68-76 [16127242] J Surg Res. 2005 Dec;129(2):236-41 [16140334] Am J Physiol Renal Physiol. 2006 Feb;290(2):F517-29 [16174863] Expert Opin Drug Metab Toxicol. 2006 Oct;2(5):697-713 [17014390] Physiol Rev. 2007 Jan;87(1):315-424 [17237348] Toxicol Pathol. 2007 Feb;35(2):270-5 [17366321] J Basic Clin Physiol Pharmacol. 2007;18(2):101-14 [17715566] Toxicol Sci. 2007 Oct;99(2):637-48 [17636248] Food Chem Toxicol. 2008 Feb;46(2):619-27 [17950512] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623309339605 ER - TY - JOUR T1 - Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States. AN - 67523526; 19423717 AB - Previous studies have shown associations between dust exposure or lung burden and emphysema in coal miners, although the separate contributions of various predictors have not been clearly demonstrated. To quantitatively evaluate the relationship between cumulative exposure to respirable coal mine dust, cigarette smoking, and other factors on emphysema severity. The study group included 722 autopsied coal miners and nonminers in the United States. Data on work history, smoking, race, and age at death were obtained from medical records and questionnaire completed by next-of-kin. Emphysema was classified and graded using a standardized schema. Job-specific mean concentrations of respirable coal mine dust were matched with work histories to estimate cumulative exposure. Relationships between various metrics of dust exposure (including cumulative exposure and lung dust burden) and emphysema severity were investigated in weighted least squares regression models. Emphysema severity was significantly elevated in coal miners compared with nonminers among ever- and never-smokers (P < 0.0001). Cumulative exposure to respirable coal mine dust or coal dust retained in the lungs were significant predictors of emphysema severity (P < 0.0001) after accounting for cigarette smoking, age at death, and race. The contributions of coal mine dust exposure and cigarette smoking were similar in predicting emphysema severity averaged over this cohort. Coal dust exposure, cigarette smoking, age, and race are significant and additive predictors of emphysema severity in this study. JF - American journal of respiratory and critical care medicine AU - Kuempel, Eileen D AU - Wheeler, Matthew W AU - Smith, Randall J AU - Vallyathan, Val AU - Green, Francis H Y AD - National Institute for Occupational Safety and Health, Education and Information Division, Risk Evaluation Branch, Cincinnati, Ohio 45226-1998, USA. ekuempel@cdc.gov Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - 257 EP - 264 VL - 180 IS - 3 KW - Dust KW - 0 KW - Tobacco Smoke Pollution KW - Abridged Index Medicus KW - Index Medicus KW - Survival Rate -- trends KW - Severity of Illness Index KW - Autopsy KW - Humans KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Pulmonary Emphysema -- etiology KW - Pulmonary Emphysema -- pathology KW - Tobacco Smoke Pollution -- adverse effects KW - Occupational Diseases -- etiology KW - Smoking -- adverse effects KW - Occupational Diseases -- pathology KW - Coal Mining KW - Pulmonary Emphysema -- mortality KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67523526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Contributions+of+dust+exposure+and+cigarette+smoking+to+emphysema+severity+in+coal+miners+in+the+United+States.&rft.au=Kuempel%2C+Eileen+D%3BWheeler%2C+Matthew+W%3BSmith%2C+Randall+J%3BVallyathan%2C+Val%3BGreen%2C+Francis+H+Y&rft.aulast=Kuempel&rft.aufirst=Eileen&rft.date=2009-08-01&rft.volume=180&rft.issue=3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1535-4970&rft_id=info:doi/10.1164%2Frccm.200806-840OC LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-06 N1 - Date created - 2009-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1164/rccm.200806-840OC ER - TY - JOUR T1 - Asthma and respiratory symptoms in hospital workers related to dampness and biological contaminants. AN - 67519791; 19500175 AB - The National Institute for Occupational Safety and Health investigated respiratory symptoms and asthma in relation to damp indoor environments in employees of two hospitals. A cluster of six work-related asthma cases from one hospital department, whose symptoms arose during a time of significant water incursions, led us to conduct a survey of respiratory health in 1171/1834 employees working in the sentinel cases hospital and a nearby hospital without known indoor environmental concerns. We carried out observational assessment of dampness, air, chair, and floor dust sampling for biological contaminants, and investigation of exposure-response associations for about 500 participants. Many participants with post-hire onset asthma reported diagnosis dates in a period of water incursions and renovations. Post-hire asthma and work-related lower respiratory symptoms were positively associated with the dampness score. Work-related lower respiratory symptoms showed monotonically increasing odds ratios with ergosterol, a marker of fungal biomass. Other fungal and bacterial indices, particle counts, cat allergen and latex allergen were associated with respiratory symptoms. Our data imply new-onset of asthma in relation to water damage, and indicate that work-related respiratory symptoms in hospital workers may be associated with diverse biological contaminants. In healthcare facilities with indoor dampness and microbial contamination, possible associations between such conditions and respiratory health effects should be considered. Good building maintenance and housekeeping procedures should lead to improvements in employee respiratory health. JF - Indoor air AU - Cox-Ganser, J M AU - Rao, C Y AU - Park, J-H AU - Schumpert, J C AU - Kreiss, K AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Jcoxganser@cdc.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 280 EP - 290 VL - 19 IS - 4 KW - Dust KW - 0 KW - Index Medicus KW - United States KW - Equipment Contamination KW - Dust -- analysis KW - Air Pollution, Indoor KW - Humans KW - Fungi -- growth & development KW - National Institute for Occupational Safety and Health (U.S.) KW - Adult KW - Health Surveys KW - Occupational Exposure -- adverse effects KW - Middle Aged KW - West Virginia -- epidemiology KW - Female KW - Male KW - Asthma -- epidemiology KW - Asthma -- etiology KW - Personnel, Hospital KW - Respiratory Insufficiency -- etiology KW - Respiratory Insufficiency -- physiopathology KW - Respiratory Insufficiency -- epidemiology KW - Asthma -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67519791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+air&rft.atitle=Asthma+and+respiratory+symptoms+in+hospital+workers+related+to+dampness+and+biological+contaminants.&rft.au=Cox-Ganser%2C+J+M%3BRao%2C+C+Y%3BPark%2C+J-H%3BSchumpert%2C+J+C%3BKreiss%2C+K&rft.aulast=Cox-Ganser&rft.aufirst=J&rft.date=2009-08-01&rft.volume=19&rft.issue=4&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=Indoor+air&rft.issn=1600-0668&rft_id=info:doi/10.1111%2Fj.1600-0668.2009.00586.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-04 N1 - Date created - 2009-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0668.2009.00586.x ER - TY - JOUR T1 - Binary weight-of-evidence evaluations of chemical interactions--15 years of experience. AN - 67502827; 19445993 AB - The paper reflects on the last 15years of experience in the field of mixtures risk assessment. It summarizes results found in various documents developed by the Agency for Toxic Substances and Disease Registry (ATSDR) of the weight-of-evidence (WOE) approach applied to 380 binary combinations of chemicals. Of these evaluations, 156 assessments indicated possible additivity of effects [=], 76 indicated synergism (greater-than-additive effects [>]), and 57 indicated antagonism (less-than-additive effects [<]). However, 91 combinations lacked the minimum information needed for making any assessments and, hence, were undetermined. The paper provides examples of the rationale behind some of the WOE decisions and discusses the importance of expert judgments in risk assessment evaluations. Examples are given regarding the importance of human variability in mixtures' ability to affect human health and regarding the dose versus effect relationships. JF - Regulatory toxicology and pharmacology : RTP AU - Pohl, Hana R AU - Mumtaz, Moiz M AU - Scinicariello, Franco AU - Hansen, Hugh AD - Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Division of Toxicology and Environmental Medicine, 1600 Clifton Road, F-32, Atlanta, GA 30333, USA. hpohl@cdc.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 264 EP - 271 VL - 54 IS - 3 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Humans KW - Risk Assessment KW - Hazardous Substances -- classification KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67502827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Binary+weight-of-evidence+evaluations+of+chemical+interactions--15+years+of+experience.&rft.au=Pohl%2C+Hana+R%3BMumtaz%2C+Moiz+M%3BScinicariello%2C+Franco%3BHansen%2C+Hugh&rft.aulast=Pohl&rft.aufirst=Hana&rft.date=2009-08-01&rft.volume=54&rft.issue=3&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2009.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-07 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2009.05.003 ER - TY - JOUR T1 - USING INSTRUMENTAL VARIABLE TESTS TO EVALUATE MODEL SPECIFICATION IN LATENT VARIABLE STRUCTURAL EQUATION MODELS AN - 60297195; 200947661 AB - Structural equation modeling (SEM) with latent variables is a powerful tool for social and behavioral scientists, combining many of the strengths of psychometrics and econometrics into a single framework. The most common estimator for SEM is the full-information maximum likelihood (ML) estimator, but there is continuing interest in limited information estimators because of their distributional robustness and their greater resistance to structural specification errors. However, the literature discussing model fit for limited information estimators for latent variable models is sparse compared with that for full-information estimators. We address this shortcoming by providing several specification tests based on the 2SLS estimator for latent variable structural equation models developed by Bollen (1996). We explain how these tests can be used not only to identify a misspecified model but to help diagnose the source of misspecification within a model. We present and discuss results from a Monte Carlo experiment designed to evaluate the finite sample properties of these tests. Our findings suggest that the 2SLS tests successfully identify most misspecified models, even those with modest misspecification, and that they provide researchers with information that can help diagnose the source of misspecification. Adapted from the source document. JF - Sociological Methodology AU - Kirby, James B AU - Bollen, Kenneth A AD - Agency for Healthcare Research and Quality Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 327 EP - 355 PB - American Sociological Association, Washington DC VL - 39 SN - 0081-1750, 0081-1750 KW - Variables KW - Statistics KW - Resistance KW - Models KW - article KW - 0104: methodology and research technology; research methods/tools UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60297195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sociological+Methodology&rft.atitle=USING+INSTRUMENTAL+VARIABLE+TESTS+TO+EVALUATE+MODEL+SPECIFICATION+IN+LATENT+VARIABLE+STRUCTURAL+EQUATION+MODELS&rft.au=Kirby%2C+James+B%3BBollen%2C+Kenneth+A&rft.aulast=Kirby&rft.aufirst=James&rft.date=2009-08-01&rft.volume=39&rft.issue=&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Sociological+Methodology&rft.issn=00811750&rft_id=info:doi/10.1111%2Fj.1467-9531.2009.01217.x LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 29 N1 - Last updated - 2016-09-28 N1 - CODEN - SOMEDX N1 - SubjectsTermNotLitGenreText - Variables; Models; Statistics; Resistance DO - http://dx.doi.org/10.1111/j.1467-9531.2009.01217.x ER - TY - JOUR T1 - Disparities in Obesity and Overweight Prevalence Among US Immigrant Children and Adolescents by Generational Status AN - 58817427; 2008-331572 AB - We examined the prevalence and socio-behavioral correlates of obesity and overweight among 46,707 immigrant and US-born children and adolescents aged 10 -17 years. The 2003 National Survey of Children's Health was used to estimate obesity and overweight prevalence among children in 12 immigrant groups, stratified by race/ethnicity and generational status. Logistic regression was used to examine immigrant differentials in the prevalence and odds of obesity and overweight. Obesity and overweight prevalence varied from a low of 6 and 18% for second-generation Asian immigrants to a high of 24 and 42% for native-born black children (US-born black children with US-born parents), respectively. After adjusting for age, gender, ethnicity, socioeconomic status, perceived neighborhood safety, television viewing, computer use, and physical activity, first-generation immigrant children, overall, had 26% lower odds of obesity than native-born children. Obesity and overweight prevalence was lower for immigrant black and white children than their native-born counterparts, while obesity and overweight prevalence among Hispanic children did not vary significantly by generational status. Compared with native-born white children, the adjusted odds of obesity were 64% higher for native-born blacks, 55% higher for second-generation Hispanic immigrants, and 63% lower for first-generation Asian immigrants. Adjusted immigrant differentials in overweight risks were also marked. Socioeconomic, demographic, and behavioral factors accounted for 61 and 35% of ethnic-immigrant disparities in obesity and overweight prevalence, respectively. Immigrant patterns in childhood obesity and overweight vary substantially by ethnicity and generational status. To reduce disparities, obesity prevention programs must target at-risk children of both immigrant and US-born parents. Adapted from the source document. JF - Journal of Community Health AU - Singh, Gopal K AU - Kogan, Michael D AU - Yu, Stella M AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD 20857, USA gsingh@hrsa.gov Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 271 EP - 281 PB - Springer, New York NY VL - 34 IS - 4 SN - 0094-5145, 0094-5145 KW - Health conditions and policy - Diseases and disorders KW - Population groups, population policy, and demographics - Immigrants and aliens KW - Population groups, population policy, and demographics - National, ethnic, and minority groups KW - Population groups, population policy, and demographics - Children and youth KW - Education and education policy - Statistics, research, research methods, and research support KW - United States KW - Obesity KW - Socioeconomic status KW - Immigrants KW - Surveys KW - Children KW - Ethnic groups KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58817427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Disparities+in+Obesity+and+Overweight+Prevalence+Among+US+Immigrant+Children+and+Adolescents+by+Generational+Status&rft.au=Singh%2C+Gopal+K%3BKogan%2C+Michael+D%3BYu%2C+Stella+M&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2009-08-01&rft.volume=34&rft.issue=4&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-009-9148-6 LA - English DB - PAIS Index N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - JCMHBR N1 - SubjectsTermNotLitGenreText - Obesity; Ethnic groups; United States; Socioeconomic status; Immigrants; Children; Surveys DO - http://dx.doi.org/10.1007/s10900-009-9148-6 ER - TY - JOUR T1 - Communication Study: Provider-patient interaction in rural Cameroon-How it relates to the patient's understanding of diagnosis and prescribed drugs, the patient's concept of illness, and access to therapy AN - 57304293; 200922761 AB - Objective This cross-sectional survey examines the relation between provider-patient interaction and several patient-outcomes in a rural health district in Cameroon. Methods We used structured patient interviews and the Roter Interaction Analysis System (RIAS) for analysis of audio-recorded consultations. Results Data from 130 primary care consultations with 13 health-care providers were analysed. 51% of patients correctly named their diagnoses after the consultation; in 47% of prescribed drugs patients explained correctly the purpose. Patients' ability to recall diagnoses was related to the extent of clarity a provider used in mentioning it during consultation (recall rates: 87.5% if mentioned explicitly, 56.7% if mentioned indirectly and 19.2% if not mentioned at all; p < 0.001). Two thirds of patients were able to describe their concept of illness before the consultation, but only 47% of them mentioned it during consultations. On average patients who mentioned their disease concept were faced with more remarks of disapproval from providers (1.73 vs 0.63 per consultation; p < 0.01). Although 41% of patients admitted problems with financial resources to buy prescribed drugs, discussion about financial issues was very rare during consultations. Providers issued financial questions in 32%, patients in 21% of consultations. Conclusion This study shows that provider-patient interaction in primary health care in a rural Cameroon district deserves more attention. It might improve the patients' knowledge about their health condition and support them in beneficial health behaviour. Practice implications Our findings should encourage providers to give more medical explanation, to discuss patients' health beliefs in a non-judgemental manner, and to consider financial issues more carefully. [Copyright Elsevier B.V.] JF - Patient Education and Counseling AU - Labhardt, Niklaus Daniel AU - Schiess, Kaspar AU - Manga, Engelbert AU - Langewitz, Wolf AD - Office of the Surgeon General Basel-Stadt, Health Department Basel-Stadt, Switzerland niklaus.labhardt@gmail.com Y1 - 2009/08// PY - 2009 DA - August 2009 SP - 196 EP - 201 PB - Elsevier Ltd, The Netherlands VL - 76 IS - 2 SN - 0738-3991, 0738-3991 KW - Roter Interaction Analysis System Primary health care in Africa Provider-patient interaction Concept of illness Communication Patient education KW - Consultation KW - Prescribed KW - Primary health care KW - Health KW - Cameroon KW - Rural communities KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57304293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Patient+Education+and+Counseling&rft.atitle=Communication+Study%3A+Provider-patient+interaction+in+rural+Cameroon-How+it+relates+to+the+patient%27s+understanding+of+diagnosis+and+prescribed+drugs%2C+the+patient%27s+concept+of+illness%2C+and+access+to+therapy&rft.au=Labhardt%2C+Niklaus+Daniel%3BSchiess%2C+Kaspar%3BManga%2C+Engelbert%3BLangewitz%2C+Wolf&rft.aulast=Labhardt&rft.aufirst=Niklaus&rft.date=2009-08-01&rft.volume=76&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Patient+Education+and+Counseling&rft.issn=07383991&rft_id=info:doi/10.1016%2Fj.pec.2008.12.020 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consultation; Prescribed; Rural communities; Cameroon; Primary health care; Health DO - http://dx.doi.org/10.1016/j.pec.2008.12.020 ER - TY - JOUR T1 - Development of a Cell Culture Method To Isolate and Enrich Salmonella enterica Serotype Enteritidis from Shell Eggs for Subsequent Detection by Real-Time PCR AN - 21490717; 12510185 AB - Salmonella enterica serotype Enteritidis is a major cause of nontyphoidal salmonellosis from ingestion of contaminated raw or undercooked shell eggs. Current techniques used to identify Salmonella serotype Enteritidis in eggs are extremely laborious and time-consuming. In this study, a novel eukaryotic cell culture system was combined with real-time PCR analysis to rapidly identify Salmonella serotype Enteritidis in raw shell eggs. The system was compared to the standard microbiological method of the International Organization for Standardization (Anonymous, Microbiology of food and animal feeding stuffs-horizontal method for the detection of Salmonella, 2002). The novel technique utilizes a mouse macrophage cell line (RAW 264.7) as the host for the isolation and intracellular replication of Salmonella serotype Enteritidis. Exposure of macrophages to Salmonella serotype Enteritidis-contaminated eggs results in uptake and intracellular replication of the bacterium, which can subsequently be detected by real-time PCR analysis of the DNA released after disruption of infected macrophages. Macrophage monolayers were exposed to eggs contaminated with various quantities of Salmonella serotype Enteritidis. As few as 10 CFU/ml was detected in cell lysates from infected macrophages after 10 h by real-time PCR using primer and probe sets specific for DNA segments located on the Salmonella serotype Enteritidis genes sefA and orgC. Salmonella serotype Enteritidis could also be distinguished from other non-serogroup D Salmonella serotypes by using the sefA- and orgC-specific primer and probe sets. Confirmatory identification of Salmonella serotype Enteritidis in eggs was also achieved by isolation of intracellular bacteria from lysates of infected macrophages on xylose lysine deoxycholate medium. This method identifies Salmonella serotype Enteritidis from eggs in less than 10 h compared to the more than 5 days required for the standard reference microbiological method of the International Organization for Standardization (Microbiology of food and animal feeding stuffs-horizontal method for the detection of Salmonella, 2002). JF - Applied and Environmental Microbiology AU - Day, J B AU - Basavanna, U AU - Sharma, S K AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, james.day@fda.hhs.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 5321 EP - 5327 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 75 IS - 16 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Cell culture KW - Serotypes KW - Salmonella KW - W 30915:Pharmaceuticals & Vaccines KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21490717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Development+of+a+Cell+Culture+Method+To+Isolate+and+Enrich+Salmonella+enterica+Serotype+Enteritidis+from+Shell+Eggs+for+Subsequent+Detection+by+Real-Time+PCR&rft.au=Day%2C+J+B%3BBasavanna%2C+U%3BSharma%2C+S+K&rft.aulast=Day&rft.aufirst=J&rft.date=2009-08-01&rft.volume=75&rft.issue=16&rft.spage=5321&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02422-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Serotypes; Salmonella DO - http://dx.doi.org/10.1128/AEM.02422-08 ER - TY - JOUR T1 - Interpreting Statistical Evidence with Empirical Likelihood Functions AN - 21100971; 11133139 AB - There has been growing interest in the likelihood paradigm of statistics, where statistical evidence is represented by the likelihood function and its strength is measured by likelihood ratios. The available literature in this area has so far focused on parametric likelihood functions, though in some cases a parametric likelihood can be robustified. This focused discussion on parametric models, while insightful and productive, may have left the impression that the likelihood paradigm is best suited to parametric situations. This article discusses the use of empirical likelihood functions, a well-developed methodology in the frequentist paradigm, to interpret statistical evidence in nonparametric and semiparametric situations. A comparative review of literature shows that, while an empirical likelihood is not a true probability density, it has the essential properties, namely consistency and local asymptotic normality that unify and justify the various parametric likelihood methods for evidential analysis. Real examples are presented to illustrate and compare the empirical likelihood method and the parametric likelihood methods. These methods are also compared in terms of asymptotic efficiency by combining relevant results from different areas. It is seen that a parametric likelihood based on a correctly specified model is generally more efficient than an empirical likelihood for the same parameter. However, when the working model fails, a parametric likelihood either breaks down or, if a robust version exists, becomes less efficient than the corresponding empirical likelihood. JF - Biometrical Journal AU - Zhang, Zhiwei AD - Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA, zhiwei.zhang@fda.hhs.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 710 EP - 720 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Statistical analysis KW - Models KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21100971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Interpreting+Statistical+Evidence+with+Empirical+Likelihood+Functions&rft.au=Zhang%2C+Zhiwei&rft.aulast=Zhang&rft.aufirst=Zhiwei&rft.date=2009-08-01&rft.volume=51&rft.issue=4&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200800209 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Statistics; Models; Statistical analysis DO - http://dx.doi.org/10.1002/bimj.200800209 ER - TY - JOUR T1 - A Personal Perspective on the Initial Federal Health-Based Regulation to Remove Lead from Gasoline AN - 21074954; 10989560 AB - Objective This article describes the personal experience and perspective of the authors, who had primary responsibility for drafting the initial health-based regulation limiting lead content of gasoline during the early 1970s while employed by the U.S. Environmental Protection Agency (EPA). Data source Information used by the U.S. EPA in developing the initial health-based regulation limiting lead content of gasoline in December 1973 and studies documenting the impact of that and subsequent actions. Data extraction Among the lessons learned from this experience is the importance of having input from independent scientists to the regulatory decision-making process. This also demonstrates the critical role of independent peer-reviewed research, such as that supported by the National Institutes of Health, as well as research conducted by scientists from the Centers for Disease Control and Prevention, in delineating the consequences of lead exposure in the population. Data synthesis Removal of lead from gasoline in the United States has been described as one of the great public health achievements of the 20th century, but it almost did not happen. The experience of the authors in developing this regulation may be helpful to others involved in developing health-based regulatory policy in the future. Conclusion The initial U.S. EPA health-based regulation to remove lead from gasoline is clearly an example where science successfully affected public policy. The leadership of the U.S. EPA at that time deserves much credit for establishing an atmosphere in which this was possible. JF - Environmental Health Perspectives AU - Bridbord, Kenneth AU - Hanson, David AD - Division of International Training and Research, Fogarty International Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1195 EP - 1201 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 117 IS - 8 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts; Pollution Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - gasoline KW - government KW - health-based regulation KW - lead KW - policy KW - U.S. EPA KW - Data processing KW - Gasoline KW - public policy KW - Disease control KW - disease control KW - Public policy KW - Atmosphere KW - Lead KW - Public health KW - EPA KW - Decision making KW - USA KW - prevention KW - responsibility KW - H 12000:Epidemiology and Public Health KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21074954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Personal+Perspective+on+the+Initial+Federal+Health-Based+Regulation+to+Remove+Lead+from+Gasoline&rft.au=Bridbord%2C+Kenneth%3BHanson%2C+David&rft.aulast=Bridbord&rft.aufirst=Kenneth&rft.date=2009-08-01&rft.volume=117&rft.issue=8&rft.spage=1195&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0800534 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Decision making; Data processing; Gasoline; Disease control; Atmosphere; Public policy; Lead; Public health; EPA; public policy; prevention; disease control; responsibility; USA DO - http://dx.doi.org/10.1289/ehp.0800534 ER - TY - JOUR T1 - Surface chemistry of dihydromyrcenol (2,6-dimethyl-7-octen-2-ol) with ozone on silanized glass, glass, and vinyl flooring tiles AN - 21070828; 10251196 AB - The surface-phase reaction products of dihydromyrcenol (2,6-dimethyl-7-octen-2-ol) with ozone (O sub(3)), air, or nitrogen (N sub(2)) on silanized glass, glass and vinyl flooring tile were investigated using the recently published FACS (FLEC (Field and Laboratory Emission Cell) Automation and Control System). The FACS was used to deliver ozone (100 ppb), air, or N sub(2) to the surface at a specified flow rate (300 mL min super(-) super(1)) and relative humidity (50%) after application of a 2.0% dihydromyrcenol solution in methanol. Oxidation products were detected using the derivatization agents: O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) and N,O-bis(trimethysilyl)trifluoroacetamide (BSTFA). The positively identified reaction products were glycolaldehyde, 2,6-dimethyl-5-heptenal, and glyoxal. The proposed oxidation products based on previously published VOC/O sub(3) reaction mechanisms were: 2,6-dimethyl-4-heptenal, 6-methyl-7-octen-2-one and the surface-specific reaction products: 6-methyl-6-hepten-2-one, 6-methyl-5-hepten-2-one, and 6-hydroxy-6-methylheptan-2-one. Though similar products were observed in gas-phase dihydromyrcenol/O sub(3) reactions, the ratio, based on peak area, of the reaction products was different suggesting stabilization of larger molecular weight species by the surface. Emission profiles of these oxidation products over 72 h are also reported. JF - Atmospheric Environment AU - Ham, JE AU - Raymond Wells, J AD - Health Effects Laboratory, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, bvo2@cdc.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 4023 EP - 4032 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 43 IS - 26 SN - 1352-2310, 1352-2310 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts KW - Relative humidity KW - surface chemistry KW - Humidity KW - Flow rates KW - Control systems KW - Oxidation KW - Volatile organic compound emissions KW - Emissions KW - Volatile organic compounds KW - Nitrogen KW - Ozone KW - M2 551.510.42:Air Pollution (551.510.42) KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21070828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Surface+chemistry+of+dihydromyrcenol+%282%2C6-dimethyl-7-octen-2-ol%29+with+ozone+on+silanized+glass%2C+glass%2C+and+vinyl+flooring+tiles&rft.au=Ham%2C+JE%3BRaymond+Wells%2C+J&rft.aulast=Ham&rft.aufirst=JE&rft.date=2009-08-01&rft.volume=43&rft.issue=26&rft.spage=4023&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2009.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Relative humidity; Volatile organic compound emissions; Oxidation; Ozone; Control systems; surface chemistry; Emissions; Humidity; Flow rates; Volatile organic compounds; Nitrogen DO - http://dx.doi.org/10.1016/j.atmosenv.2009.05.007 ER - TY - JOUR T1 - Proteomics-based characterization of hemagglutinins in different strains of influenza virus AN - 20975311; 11052402 AB - Infection with influenza A (subtypes H1N1 and H3N2) or B viruses results in over half a million deaths worldwide every year. Frequent antigenic changes (drift) in two major viral surface proteins hemagglutinin (HA) and neuraminidase lead to the constant emergence of antigenically distinct virus strains against which there is sub-optimal immunity in the population. Consequently the suitability of the viral strains included in the trivalent influenza vaccine (TIV) has to be re-evaluated annually. While virus seeds selected for vaccine manufacture are very well characterized, there is no assay in place to identify the source of HA in the formulated trivalent vaccine. Our study describes a proteomics-based method to identify the HA strain (not just subtype) and more fully characterize the final vaccine product. Unique and shared tryptic peptides of HAs were predicted by in silico tryptic digest of different influenza A and B virus strains. Recombinant HA and whole virus preparations of selected strains were then digested to identify the peptides detected by MS. Both subtype and strain-specific peptides were observed. The feasibility of this method to accurately identify HA strains in an inactivated TIV was tested using a 2006/2007 formulation. Each of the three HAs in the vaccine was identified in addition to a number of other viral and non-viral proteins. In summary, MS is a powerful method that is both specific and inclusive; in a single analysis, HAs of individual virus strains can be identified and the composition of the TIV fully characterized. JF - Proteomics Clinical Applications AU - Getie-Kebtie, M AU - Chen, D AU - Eichelberger, M AU - Alterman, M AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologies Evaluation and Research, Food and Drug Administration. Building 29A, Room 2D12, 8800 Rockville Pike, Bethesda, MD 20892, USA, Michail.Alterman@fda.hhs.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 979 EP - 988 VL - 3 IS - 8 SN - 1862-8346, 1862-8346 KW - Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Influenza virus KW - Drift KW - Influenza A KW - Hemagglutinins KW - Exo-a-sialidase KW - Therapeutic applications KW - Tryptic peptides KW - Vaccines KW - proteomics KW - Immunity KW - Infection KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20975311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Proteomics-based+characterization+of+hemagglutinins+in+different+strains+of+influenza+virus&rft.au=Getie-Kebtie%2C+M%3BChen%2C+D%3BEichelberger%2C+M%3BAlterman%2C+M&rft.aulast=Getie-Kebtie&rft.aufirst=M&rft.date=2009-08-01&rft.volume=3&rft.issue=8&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200800219 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Drift; Hemagglutinins; Influenza A; Exo-a-sialidase; Therapeutic applications; Tryptic peptides; Immunity; proteomics; Vaccines; Infection; Influenza virus DO - http://dx.doi.org/10.1002/prca.200800219 ER - TY - JOUR T1 - Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization AN - 20939777; 10988664 AB - Learned associations between effects of abused drugs and the drug administration environment are important in drug addiction. Histochemical and electrophysiological studies suggest that these associations are encoded in sparsely distributed nucleus accumbens neurons that are selectively activated by drugs and drug-associated cues. Although correlations have been observed between nucleus accumbens neuronal activity and responsivity to drugs and drug cues, no technique exists for selectively manipulating these activated neurons and establishing their causal role in behavioral effects of drugs and drug cues. Here we describe a new approach, which we term the 'Daun02 inactivation method', that selectively inactivates a minority of neurons previously activated by cocaine in an environment repeatedly paired with cocaine to demonstrate a causal role for these activated neurons in context-specific cocaine-induced psychomotor sensitization in rats. This method provides a new tool for studying the causal roles of selectively activated neurons in behavioral effects of drugs and drug cues and in other learned behaviors. JF - Nature Neuroscience AU - Koya, Eisuke AU - Golden, Sam A AU - Harvey, Brandon K AU - Guez-Barber, Danielle H AU - Berkow, Alexander AU - Simmons, Danielle E AU - Bossert, Jennifer M AU - Nair, Sunila G AU - Uejima, Jamie L AU - Marin, Marcelo T AU - Mitchell, Timothy B AU - Farquhar, David AU - Ghosh, Sukhen C AU - Mattson, Brandi J AU - Hope, Bruce T AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 1069 EP - 1073 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 12 IS - 8 SN - 1097-6256, 1097-6256 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Nucleus accumbens KW - Electrophysiological recording KW - Nervous system KW - Neurons KW - Drug abuse KW - Cocaine KW - Drug addiction KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20939777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Neuroscience&rft.atitle=Targeted+disruption+of+cocaine-activated+nucleus+accumbens+neurons+prevents+context-specific+sensitization&rft.au=Koya%2C+Eisuke%3BGolden%2C+Sam+A%3BHarvey%2C+Brandon+K%3BGuez-Barber%2C+Danielle+H%3BBerkow%2C+Alexander%3BSimmons%2C+Danielle+E%3BBossert%2C+Jennifer+M%3BNair%2C+Sunila+G%3BUejima%2C+Jamie+L%3BMarin%2C+Marcelo+T%3BMitchell%2C+Timothy+B%3BFarquhar%2C+David%3BGhosh%2C+Sukhen+C%3BMattson%2C+Brandi+J%3BHope%2C+Bruce+T&rft.aulast=Koya&rft.aufirst=Eisuke&rft.date=2009-08-01&rft.volume=12&rft.issue=8&rft.spage=1069&rft.isbn=&rft.btitle=&rft.title=Nature+Neuroscience&rft.issn=10976256&rft_id=info:doi/10.1038%2Fnn.2364 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Electrophysiological recording; Nucleus accumbens; Nervous system; Neurons; Drug addiction; Cocaine; Drug abuse DO - http://dx.doi.org/10.1038/nn.2364 ER - TY - JOUR T1 - Characterization of an ATP-binding cassette from Clostridium perfringens with homology to an ABC transporter from Clostridium hathewayi AN - 20701404; 10828172 AB - A ciprofloxacin-resistant mutant of Clostridium perfringens, strain VPI-C, which had stable mutations in the topoisomerase genes, accumulated less norfloxacin and ethidium bromide than the wild type, strain VPI. Efflux pump inhibitors both increased the accumulation of ethidium bromide by cells of the mutant and enhanced their sensitivity to this toxic dye. Cloning a gene, which codes for a putative ABC transporter protein (NP_562422) of 527 amino acids, from the mutant strain VPI-C into the wild-type strain VPI not only reduced the accumulation of ethidium bromide by the recombinant strain but also reduced its sensitivity to norfloxacin and ciprofloxacin. Efflux pump inhibitors decreased the rate at which ethidium bromide was removed from the cells of the recombinant strain. It appears that the putative ABC transporter protein (NP_562422) may contribute to extrusion of drugs from C. perfringens. JF - Anaerobe AU - Rafii, Fatemeh AU - Park, Miseon AU - Carman, Robert J AD - Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA, fatemeh.rafii@fda.hhs.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 116 EP - 121 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 15 IS - 4 SN - 1075-9964, 1075-9964 KW - Microbiology Abstracts B: Bacteriology KW - ABC transporter KW - Clostridium KW - Ethidium bromide KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20701404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Characterization+of+an+ATP-binding+cassette+from+Clostridium+perfringens+with+homology+to+an+ABC+transporter+from+Clostridium+hathewayi&rft.au=Rafii%2C+Fatemeh%3BPark%2C+Miseon%3BCarman%2C+Robert+J&rft.aulast=Rafii&rft.aufirst=Fatemeh&rft.date=2009-08-01&rft.volume=15&rft.issue=4&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2009.01.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Ethidium bromide; Clostridium DO - http://dx.doi.org/10.1016/j.anaerobe.2009.01.008 ER - TY - JOUR T1 - Mechanisms of cadmium carcinogenesis AN - 20685217; 10135393 AB - Cadmium (Cd), a heavy metal of considerable occupational and environmental concern, has been classified as a human carcinogen by the International Agency for Research on Cancer (IARC). The carcinogenic potential of Cd as well as the mechanisms underlying carcinogenesis following exposure to Cd has been studied using in vitro cell culture and in vivo animal models. Exposure of cells to Cd results in their transformation. Administration of Cd in animals results in tumors of multiple organs/tissues. Also, a causal relationship has been noticed between exposure to Cd and the incidence of lung cancer in human. It has been demonstrated that Cd induces cancer by multiple mechanisms and the most important among them are aberrant gene expression, inhibition of DNA damage repair, induction of oxidative stress, and inhibition of apoptosis. The available evidence indicates that, perhaps, oxidative stress plays a central role in Cd carcinogenesis because of its involvement in Cd-induced aberrant gene expression, inhibition of DNA damage repair, and apoptosis. JF - Toxicology and Applied Pharmacology AU - Joseph, P AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA, pjoseph1@cdc.gov Y1 - 2009/08/01/ PY - 2009 DA - 2009 Aug 01 SP - 272 EP - 279 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 238 IS - 3 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - Transformation KW - Apoptosis KW - Heavy metals KW - Animal models KW - tumors KW - Cell culture KW - Carcinogens KW - Tumors KW - Organs KW - Cancer KW - oxidative stress KW - Gene expression KW - DNA damage KW - Carcinogenicity KW - Oxidative stress KW - Carcinogenesis KW - DNA KW - Cadmium KW - heavy metals KW - Lung cancer KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20685217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Mechanisms+of+cadmium+carcinogenesis&rft.au=Joseph%2C+P&rft.aulast=Joseph&rft.aufirst=P&rft.date=2009-08-01&rft.volume=238&rft.issue=3&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.01.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Transformation; Apoptosis; Heavy metals; Animal models; Cell culture; Tumors; Carcinogens; Gene expression; DNA damage; Oxidative stress; Carcinogenesis; Cadmium; Lung cancer; Carcinogenicity; DNA; tumors; Organs; heavy metals; oxidative stress; Cancer DO - http://dx.doi.org/10.1016/j.taap.2009.01.011 ER - TY - JOUR T1 - High-throughput real-time PCR for early detection and quantitation of arenavirus Tacaribe AN - 20617297; 9352518 AB - Arenaviruses merit significant attention both as causative agents of endemic hemorrhagic fevers and as model systems to study the immune response to acute and persistent viral infections. Development of highly sensitive quantitative screening methods to detect arenavirus is critical for early diagnosis of patients, to screen the rodent population in endemic areas, and as a research tool to confirm effective tissue clearance during the development of anti-viral strategies. This study describes a novel sensitive and reproducible method to quantify prototypic new world arenavirus Tacaribe RNA in cell cultures and tissues using a real-time TaqMan PCR-based detection system. The method has a sensitivity of 100 RNA copies per 200ng of total RNA, making it 2 logs more sensitive than the currently utilized TCID sub(5) sub(0) method, and a linear range from 10 super(2) to 10 super(9) copies/reaction. The qRT-PCR method is high-throughput and screening can be achieved in <2h allowing for diagnosis of infected patients before the onset of symptoms. This new method is a powerful tool to screen populations for infection and monitor the clearance achieved by available therapies, and serves as a model diagnostic tool for other arenaviruses. JF - Journal of Virological Methods AU - Grajkowska, L T AU - Pedras-Vasconcelos, JA AU - Sauder, C AU - Verthelyi, D AU - Puig, M AD - Office of Biotechnology Products, CDER, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA, Daniela.verthelyi@fda.hhs.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - 239 EP - 243 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 159 IS - 2 SN - 0166-0934, 0166-0934 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - RNA KW - Antiviral agents KW - Animal models KW - Hemorrhagic fever KW - Polymerase chain reaction KW - Cell culture KW - Immune response KW - Infection KW - Quantitation KW - Arenavirus KW - V 22300:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20617297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=High-throughput+real-time+PCR+for+early+detection+and+quantitation+of+arenavirus+Tacaribe&rft.au=Grajkowska%2C+L+T%3BPedras-Vasconcelos%2C+JA%3BSauder%2C+C%3BVerthelyi%2C+D%3BPuig%2C+M&rft.aulast=Grajkowska&rft.aufirst=L&rft.date=2009-08-01&rft.volume=159&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2009.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Antiviral agents; RNA; Animal models; Polymerase chain reaction; Hemorrhagic fever; Cell culture; Immune response; Infection; Quantitation; Arenavirus DO - http://dx.doi.org/10.1016/j.jviromet.2009.04.001 ER - TY - JOUR T1 - Allergen databases and allergen semantics AN - 20095576; 10241609 AB - The efficacy of any specific bioinformatic analysis of the potential allergenicity of new food proteins depends directly on the nature and content of the databases that are used in the analysis. A number of different allergen-related databases have been developed, each designed to meet a different need. These databases differ in content, organization, and accessibility. These differences create barriers for users and prevent data sharing and integration. The development and application of appropriate semantic web technologies, (for example, a food allergen ontology) could help to overcome these barriers and promote the development of more advanced analytic capabilities. JF - Regulatory Toxicology and Pharmacology AU - Gendel, S M AD - Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, United States, steven.gendel@fda.hhs.gov Y1 - 2009/08// PY - 2009 DA - Aug 2009 SP - S7 EP - S10 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 54 IS - 3 SN - 0273-2300, 0273-2300 KW - Immunology Abstracts; Toxicology Abstracts KW - Databases KW - Integration KW - Food hypersensitivity KW - Data processing KW - Allergens KW - Allergenicity KW - Bioinformatics KW - Semantics KW - F 06955:Immunomodulation & Immunopharmacology KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20095576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Allergen+databases+and+allergen+semantics&rft.au=Gendel%2C+S+M&rft.aulast=Gendel&rft.aufirst=S&rft.date=2009-08-01&rft.volume=54&rft.issue=3&rft.spage=S7&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2008.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Integration; Databases; Data processing; Food hypersensitivity; Allergenicity; Allergens; Bioinformatics; Semantics DO - http://dx.doi.org/10.1016/j.yrtph.2008.10.011 ER - TY - JOUR T1 - Internal contamination and spoilage of harvested apples by patulin-producing and other toxigenic fungi. AN - 733361642; 19524316 AB - A total of 424 apple samples comprised of six varieties (Gala, Red Delicious, Golden Delicious, Fuji, Granny Smith, and Braeburn) were analyzed for internal fungal contamination. Two hundred sixteen apples were incubated intact for 2-4 weeks at room temperature. The cores of the remaining 208 apples were aseptically removed and incubated without supplemental media at room temperature for 3 weeks. After the incubation period was over, the mycological profiles of the analyzed samples were determined. Twelve per cent of the intact apples showed visible growth after 2-4 weeks of incubation at room temperature. Penicillia (including the patulin producer, Penicillium expansum) were the most frequent, found in 8% of the samples followed by Fusarium and Alternaria spp. (each found in 3% of the samples tested). The highest mould incidence was observed in the Red Delicious and Fuji and the lowest in the Granny Smith variety. A variety of microfungi including members of the toxigenic genera Alternaria, Penicillium and Fusarium were isolated from the apple cores. The predominant moulds were Alternaria, Cladosporium, Penicillium and Fusarium spp. recovered from 50, 22, 33 and 23% of the analyzed samples, respectively. Less common were Ulocladium spp., Botrytis cinerea and Aureobasidium pullulans found in less than 4% of the samples. Yeasts were found only in 2% of the samples. Apple cores from all varieties tested showed a high degree of mould contamination. JF - International journal of food microbiology AU - Tournas, V H AU - Uppal Memon, S AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740, USA. valerie.tournas@fda.hhs.gov Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 SP - 206 EP - 209 VL - 133 IS - 1-2 KW - Mycotoxins KW - 0 KW - Index Medicus KW - Humans KW - Food Contamination KW - Malus -- microbiology KW - Food Microbiology KW - Fruit -- microbiology KW - Fungi -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733361642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+food+microbiology&rft.atitle=Internal+contamination+and+spoilage+of+harvested+apples+by+patulin-producing+and+other+toxigenic+fungi.&rft.au=Tournas%2C+V+H%3BUppal+Memon%2C+S&rft.aulast=Tournas&rft.aufirst=V&rft.date=2009-07-31&rft.volume=133&rft.issue=1-2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=International+journal+of+food+microbiology&rft.issn=1879-3460&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2009.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-02 N1 - Date created - 2009-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2009.05.025 ER - TY - CPAPER T1 - Challenges in Regulatory Marketing Approval of Drugs for the Treatment of Advanced Non-Small Cell Lung Cancer Based on Noninferiority Trials T2 - 13th World Conference on Lung Cancer AN - 40355321; 5265688 JF - 13th World Conference on Lung Cancer AU - Malik, Shakun Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Marketing KW - Lung cancer KW - Drugs KW - Non-small cell lung carcinoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Challenges+in+Regulatory+Marketing+Approval+of+Drugs+for+the+Treatment+of+Advanced+Non-Small+Cell+Lung+Cancer+Based+on+Noninferiority+Trials&rft.au=Malik%2C+Shakun&rft.aulast=Malik&rft.aufirst=Shakun&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Approved Therapies for Advanced Non- Small Cell Lung Cancer,Food and Drug Administration Overview T2 - 13th World Conference on Lung Cancer AN - 40353487; 5265686 JF - 13th World Conference on Lung Cancer AU - Malik, Shakun Y1 - 2009/07/31/ PY - 2009 DA - 2009 Jul 31 KW - Lung KW - Drugs KW - Reviews KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40353487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+World+Conference+on+Lung+Cancer&rft.atitle=Approved+Therapies+for+Advanced+Non-+Small+Cell+Lung+Cancer%2CFood+and+Drug+Administration+Overview&rft.au=Malik%2C+Shakun&rft.aulast=Malik&rft.aufirst=Shakun&rft.date=2009-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.meet-ics.com/wclc2009/pdf/FINAL-WEBVERSION-web2-WCLC2009ons ite.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - RPRT T1 - Seventeen Year Old Female Laborer Falls From Residential Roof and Dies Nine Days Later Connecticut AN - 20958906; 11069913 AB - On July 2, 2007, a 17-year-old female laborer (the victim) fell approximately 26 feet from a residential roof to a stone patio; she died nine days later from her injuries. The victim was working for a construction company replacing a residential roof. The victim unloaded bales of roofing shingles from a construction box that was raised and attached to a forklift. The victim unloaded the bales and placed them on a wooden plank above her on the roof. The victim then sat on the plank and handed the bales to one of the owners of the company and a male laborer. While working on the roof, one of the owners and the male laborer heard a "thud" and looked over at the plank, but did not see the victim. They moved to the edge of the roof and looked down and saw the victim lying face down on a stone patio. The owner and the male laborer climbed down from the roof. While climbing down the owner yelled to the other owner in the yard area to go check on the victim. When the owner got down from the roof he called 911 for help, as the other owner checked the victim. During this time, the victim was lying unconscious and her head was bleeding profusely. Emergency Medical Services (EMS) and the state police were dispatched to the incident, and the victim was transported via ambulance to an area hospital. At the hospital the victim was stabilized, then airlifted to another hospital where she remained unconscious in critical condition. She died from her injuries nine days later. Key contributing factors identified in this investigation include failure to recognize and control the fall hazard and assignment of a young worker to a prohibited hazardous task. NIOSH investigators concluded that, to help prevent similar occurrences, employers should: know and comply with child labor laws which include prohibitions against work by youths less than 18 years of age in occupations that involve roofing ensure that workers are protected against falling while working at an elevation and that fall protection is provided when the potential for falls exist on the worksite develop, implement, and enforce a comprehensive occupational safety and health program that includes training workers in hazard recognition and the avoidance of unsafe conditions. JF - Seventeen Year Old Female Laborer Falls From Residential Roof and Dies Nine Days Later Connecticut. [vp]. 30 Jul 2009. Y1 - 2009/07/30/ PY - 2009 DA - 2009 Jul 30 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Age KW - Injuries KW - USA, Connecticut KW - Training KW - Occupational safety KW - Working conditions KW - police KW - Females KW - emergency medical services KW - Hospitals KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20958906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Seventeen+Year+Old+Female+Laborer+Falls+From+Residential+Roof+and+Dies+Nine+Days+Later+Connecticut&rft.title=Seventeen+Year+Old+Female+Laborer+Falls+From+Residential+Roof+and+Dies+Nine+Days+Later+Connecticut&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - U.S. FOOD AND DRUG ADMINISTRATION HEADQUARTERS CONSOLIDATION, MONTGOMERY COUNTY, MARYLAND (FINAL SUPPLEMENT TO THE FINAL ENVIRONMENTAL IMPACT STATEMENT OF APRIL 1997). [Part 2 of 2] T2 - U.S. FOOD AND DRUG ADMINISTRATION HEADQUARTERS CONSOLIDATION, MONTGOMERY COUNTY, MARYLAND (FINAL SUPPLEMENT TO THE FINAL ENVIRONMENTAL IMPACT STATEMENT OF APRIL 1997). AN - 756826253; 13965-090261_0002 AB - PURPOSE: Revisions to the Food and Drug Administration's (FDA) 2006 Master Plan for the consolidation of FDA's headquarters facilities to a state-of-the-art facility on one location in Silver Spring, Montgomery County, Maryland are proposed. The General Services Administration (GSA) is currently developing new facilities at the Federal Research Center (FRC) at White Oak for FDA's Office of the Commissioner, Office of Regulatory Affairs, the Center for Drug Evaluation and Research, the Center for Devices and Radiological Health, the Center for Biologics Evaluation and Research, and the Center for Veterinary Medicine. Since the preparation of the 1997 final EIS and the 2005 final supplemental EIS, congressional mandates have resulted in expansions to FDA's programs and GSA is updating the FDA Headquarters Master Plan to accommodate additional growth on the 130-acre campus. The plan is based on grouping buildings for the six FDA research and administrative functions around a central campus that serves to unite the functions and link the campus to the woodlands to the east. Three alternatives, including a No Action Alternative, are considered in this final supplemental EIS. The proposed action would construct facilities to accommodate the increase of FDA employees from 7,719 to 8,889, change the placement of a 21,000-square foot child care center, construct a 10,000-square foot fitness center, relocate the 25,000-square foot broadcast studio, expand the central utility plant by 50,000 square feet, and construct a 300,000 gallon elevated water storage tank for potable water. The proposed action would add an additional 1.3 million gross square feet of space to support FDA's mission for a total of almost 6 million square feet. Two parking spaces would be provided for every three employees while visitor parking would be increased from 500 to 1,000 spaces for a total of 6,926 parking spaces on the FDA campus. The Dispersed Density action alternative (Alternative 2) is the preferred alternative and would follow existing heights keeping uniformity across the campus and would add a northwest parking garage. Under the Southeast Quadrant Density action alternative (Alternative 3), building heights would be greater than that of existing buildings locating most of the density in the southeastern part of the campus. POSITIVE IMPACTS: The proposed action would accommodate the projected increase in FDA personnel within the 130 acres appropriated by Congress for the FDA headquarters. Expanded office and laboratory space and the associated infrastructure improvements would allow the additional employees to conduct the complex and comprehensive reviews of new drugs and medical devices which are part of FDA's mandated programs. The use of the central utility plant would have moderate, long-term beneficial impacts to overall energy supplies. Under the action alternatives, employment would increase by 1,170 employees by 2012. NEGATIVE IMPACTS: The proposed action would have adverse impacts from the clearing, grading, and construction activities that would affect soils. An erosion and sediment plan would be implemented to control and reduce sediments from entering storm drains and adjacent streams. The total impervious surface area under alternatives 2 and 3 would be increased by 5.6 and 2.9 acres, respectively over the No Action alternative, with consequent minor, long-term, adverse effects to groundwater quality and hydrology. The proposed locations for the broadcast studio and water storage tank would have direct impacts to wetlands and associated buffers. Under the action alternatives, the FDA headquarters consolidation would continue to have impacts on traffic levels with the additional employees generating approximately 777 vehicle trips in the morning and evening peak hours and improvements to several intersections would be needed. Buildings proposed under the action alternatives would adversely impact views from adjacent streets and apartment communities. The proposed water tower would have a total elevation of 471 to 476 feet and would stand more than 20 feet taller than any surrounding structure. LEGAL MANDATES: National Capital Planning Act of 1952 (40 U.S.C. 71d(a)) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstracts of the draft and final EISs, see 96-0183D, Volume 20, Number 2 and 97-0143F, Volume 21, Number 2, respectively. JF - EPA number: 090261, Final Supplemental EIS--210 pages, Appendices--389 pages and maps, July 24, 2009 PY - 2009 VL - 2 KW - Urban and Social Programs KW - Air Quality Assessments KW - Buildings KW - Employment KW - Forests KW - Health Hazard KW - Land Use KW - Noise Assessments KW - Parking KW - Public Health KW - Research Facilities KW - Site Planning KW - Traffic Analyses KW - Water Storage KW - Maryland KW - National Historic Preservation Act of 1966, Historic Sites KW - National Capital Planning Act of 1952, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756826253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-07-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28FINAL+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+APRIL+1997%29.&rft.title=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28FINAL+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+APRIL+1997%29.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Washington, District of Columbia; GSA N1 - Date revised - 2009-09-01 N1 - SuppNotes - Final. Preparation date: July 24, 2009 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - U.S. FOOD AND DRUG ADMINISTRATION HEADQUARTERS CONSOLIDATION, MONTGOMERY COUNTY, MARYLAND (FINAL SUPPLEMENT TO THE FINAL ENVIRONMENTAL IMPACT STATEMENT OF APRIL 1997). [Part 1 of 2] T2 - U.S. FOOD AND DRUG ADMINISTRATION HEADQUARTERS CONSOLIDATION, MONTGOMERY COUNTY, MARYLAND (FINAL SUPPLEMENT TO THE FINAL ENVIRONMENTAL IMPACT STATEMENT OF APRIL 1997). AN - 756826239; 13965-090261_0001 AB - PURPOSE: Revisions to the Food and Drug Administration's (FDA) 2006 Master Plan for the consolidation of FDA's headquarters facilities to a state-of-the-art facility on one location in Silver Spring, Montgomery County, Maryland are proposed. The General Services Administration (GSA) is currently developing new facilities at the Federal Research Center (FRC) at White Oak for FDA's Office of the Commissioner, Office of Regulatory Affairs, the Center for Drug Evaluation and Research, the Center for Devices and Radiological Health, the Center for Biologics Evaluation and Research, and the Center for Veterinary Medicine. Since the preparation of the 1997 final EIS and the 2005 final supplemental EIS, congressional mandates have resulted in expansions to FDA's programs and GSA is updating the FDA Headquarters Master Plan to accommodate additional growth on the 130-acre campus. The plan is based on grouping buildings for the six FDA research and administrative functions around a central campus that serves to unite the functions and link the campus to the woodlands to the east. Three alternatives, including a No Action Alternative, are considered in this final supplemental EIS. The proposed action would construct facilities to accommodate the increase of FDA employees from 7,719 to 8,889, change the placement of a 21,000-square foot child care center, construct a 10,000-square foot fitness center, relocate the 25,000-square foot broadcast studio, expand the central utility plant by 50,000 square feet, and construct a 300,000 gallon elevated water storage tank for potable water. The proposed action would add an additional 1.3 million gross square feet of space to support FDA's mission for a total of almost 6 million square feet. Two parking spaces would be provided for every three employees while visitor parking would be increased from 500 to 1,000 spaces for a total of 6,926 parking spaces on the FDA campus. The Dispersed Density action alternative (Alternative 2) is the preferred alternative and would follow existing heights keeping uniformity across the campus and would add a northwest parking garage. Under the Southeast Quadrant Density action alternative (Alternative 3), building heights would be greater than that of existing buildings locating most of the density in the southeastern part of the campus. POSITIVE IMPACTS: The proposed action would accommodate the projected increase in FDA personnel within the 130 acres appropriated by Congress for the FDA headquarters. Expanded office and laboratory space and the associated infrastructure improvements would allow the additional employees to conduct the complex and comprehensive reviews of new drugs and medical devices which are part of FDA's mandated programs. The use of the central utility plant would have moderate, long-term beneficial impacts to overall energy supplies. Under the action alternatives, employment would increase by 1,170 employees by 2012. NEGATIVE IMPACTS: The proposed action would have adverse impacts from the clearing, grading, and construction activities that would affect soils. An erosion and sediment plan would be implemented to control and reduce sediments from entering storm drains and adjacent streams. The total impervious surface area under alternatives 2 and 3 would be increased by 5.6 and 2.9 acres, respectively over the No Action alternative, with consequent minor, long-term, adverse effects to groundwater quality and hydrology. The proposed locations for the broadcast studio and water storage tank would have direct impacts to wetlands and associated buffers. Under the action alternatives, the FDA headquarters consolidation would continue to have impacts on traffic levels with the additional employees generating approximately 777 vehicle trips in the morning and evening peak hours and improvements to several intersections would be needed. Buildings proposed under the action alternatives would adversely impact views from adjacent streets and apartment communities. The proposed water tower would have a total elevation of 471 to 476 feet and would stand more than 20 feet taller than any surrounding structure. LEGAL MANDATES: National Capital Planning Act of 1952 (40 U.S.C. 71d(a)) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstracts of the draft and final EISs, see 96-0183D, Volume 20, Number 2 and 97-0143F, Volume 21, Number 2, respectively. JF - EPA number: 090261, Final Supplemental EIS--210 pages, Appendices--389 pages and maps, July 24, 2009 PY - 2009 VL - 1 KW - Urban and Social Programs KW - Air Quality Assessments KW - Buildings KW - Employment KW - Forests KW - Health Hazard KW - Land Use KW - Noise Assessments KW - Parking KW - Public Health KW - Research Facilities KW - Site Planning KW - Traffic Analyses KW - Water Storage KW - Maryland KW - National Historic Preservation Act of 1966, Historic Sites KW - National Capital Planning Act of 1952, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756826239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-07-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28FINAL+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+APRIL+1997%29.&rft.title=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28FINAL+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+APRIL+1997%29.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Washington, District of Columbia; GSA N1 - Date revised - 2009-09-01 N1 - SuppNotes - Final. Preparation date: July 24, 2009 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - U.S. FOOD AND DRUG ADMINISTRATION HEADQUARTERS CONSOLIDATION, MONTGOMERY COUNTY, MARYLAND (FINAL SUPPLEMENT TO THE FINAL ENVIRONMENTAL IMPACT STATEMENT OF APRIL 1997). AN - 36347332; 13965 AB - PURPOSE: Revisions to the Food and Drug Administration's (FDA) 2006 Master Plan for the consolidation of FDA's headquarters facilities to a state-of-the-art facility on one location in Silver Spring, Montgomery County, Maryland are proposed. The General Services Administration (GSA) is currently developing new facilities at the Federal Research Center (FRC) at White Oak for FDA's Office of the Commissioner, Office of Regulatory Affairs, the Center for Drug Evaluation and Research, the Center for Devices and Radiological Health, the Center for Biologics Evaluation and Research, and the Center for Veterinary Medicine. Since the preparation of the 1997 final EIS and the 2005 final supplemental EIS, congressional mandates have resulted in expansions to FDA's programs and GSA is updating the FDA Headquarters Master Plan to accommodate additional growth on the 130-acre campus. The plan is based on grouping buildings for the six FDA research and administrative functions around a central campus that serves to unite the functions and link the campus to the woodlands to the east. Three alternatives, including a No Action Alternative, are considered in this final supplemental EIS. The proposed action would construct facilities to accommodate the increase of FDA employees from 7,719 to 8,889, change the placement of a 21,000-square foot child care center, construct a 10,000-square foot fitness center, relocate the 25,000-square foot broadcast studio, expand the central utility plant by 50,000 square feet, and construct a 300,000 gallon elevated water storage tank for potable water. The proposed action would add an additional 1.3 million gross square feet of space to support FDA's mission for a total of almost 6 million square feet. Two parking spaces would be provided for every three employees while visitor parking would be increased from 500 to 1,000 spaces for a total of 6,926 parking spaces on the FDA campus. The Dispersed Density action alternative (Alternative 2) is the preferred alternative and would follow existing heights keeping uniformity across the campus and would add a northwest parking garage. Under the Southeast Quadrant Density action alternative (Alternative 3), building heights would be greater than that of existing buildings locating most of the density in the southeastern part of the campus. POSITIVE IMPACTS: The proposed action would accommodate the projected increase in FDA personnel within the 130 acres appropriated by Congress for the FDA headquarters. Expanded office and laboratory space and the associated infrastructure improvements would allow the additional employees to conduct the complex and comprehensive reviews of new drugs and medical devices which are part of FDA's mandated programs. The use of the central utility plant would have moderate, long-term beneficial impacts to overall energy supplies. Under the action alternatives, employment would increase by 1,170 employees by 2012. NEGATIVE IMPACTS: The proposed action would have adverse impacts from the clearing, grading, and construction activities that would affect soils. An erosion and sediment plan would be implemented to control and reduce sediments from entering storm drains and adjacent streams. The total impervious surface area under alternatives 2 and 3 would be increased by 5.6 and 2.9 acres, respectively over the No Action alternative, with consequent minor, long-term, adverse effects to groundwater quality and hydrology. The proposed locations for the broadcast studio and water storage tank would have direct impacts to wetlands and associated buffers. Under the action alternatives, the FDA headquarters consolidation would continue to have impacts on traffic levels with the additional employees generating approximately 777 vehicle trips in the morning and evening peak hours and improvements to several intersections would be needed. Buildings proposed under the action alternatives would adversely impact views from adjacent streets and apartment communities. The proposed water tower would have a total elevation of 471 to 476 feet and would stand more than 20 feet taller than any surrounding structure. LEGAL MANDATES: National Capital Planning Act of 1952 (40 U.S.C. 71d(a)) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstracts of the draft and final EISs, see 96-0183D, Volume 20, Number 2 and 97-0143F, Volume 21, Number 2, respectively. JF - EPA number: 090261, Final Supplemental EIS--210 pages, Appendices--389 pages and maps, July 24, 2009 PY - 2009 KW - Urban and Social Programs KW - Air Quality Assessments KW - Buildings KW - Employment KW - Forests KW - Health Hazard KW - Land Use KW - Noise Assessments KW - Parking KW - Public Health KW - Research Facilities KW - Site Planning KW - Traffic Analyses KW - Water Storage KW - Maryland KW - National Historic Preservation Act of 1966, Historic Sites KW - National Capital Planning Act of 1952, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36347332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-07-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28FINAL+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+APRIL+1997%29.&rft.title=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28FINAL+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+APRIL+1997%29.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Washington, District of Columbia; GSA N1 - Date revised - 2009-09-01 N1 - SuppNotes - Final. Preparation date: July 24, 2009 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Acrylamide decreased dopamine levels and increased 3-nitrotyrosine (3-NT) levels in PC 12 cells AN - 877597103; 13712931 AB - Acrylamide is a chemical known to produce neurotoxicity in animals, as well as in humans. The mechanism of acrylamide-induced neurotoxicity is not fully known. However, recent studies have revealed that acrylamide affects the dopaminergic system. Therefore, the aim of this study was to investigate the effect of acrylamide on dopamine (DA) and the metabolites, 3,4-dihydroxy phenylacetic acid (DOPAC) and homovanillicacid (HVA), levels in Pheochromocytoma (PC 12) cells. In addition, the generation of peroxynitrite (ONOO super(-)), measured by 3-nitrotyrosine (3-NT), was investigated as a possible mechanism in acrylamide-induced neurotoxicity. HPLC-coupled to electrochemical detection (ECD) was used to determine DA, DOPAC, HVA and 3-NT levels. Acrylamide (0.01-5 mM) exposure produced a dose- and time (1-42 h)-dependent decrease in da levels. The decrease (P < 0.05) in da levels was noted at 24 h after exposure to acrylamide. The study also revealed that 3-NT levels in PC 12 increased as a result of treatment with acrylamide. Thus, these data suggest that acrylamide-induced decrease in da levels in PC 12 cells may be associated with peroxynitrite formation, measured as 3-NT levels. JF - Neuroscience Letters AU - Tareke, Eden AU - Lyn-Cook, Beverly D AU - Duhart, Helen AU - Newport, Glenn AU - Ali, Syed AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA, edunatar@hotmail.com Y1 - 2009/07/17/ PY - 2009 DA - 2009 Jul 17 SP - 89 EP - 92 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB UK VL - 458 IS - 2 SN - 0304-3940, 0304-3940 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Acrylamide KW - N3:11028 KW - X:24320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877597103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+Letters&rft.atitle=Acrylamide+decreased+dopamine+levels+and+increased+3-nitrotyrosine+%283-NT%29+levels+in+PC+12+cells&rft.au=Tareke%2C+Eden%3BLyn-Cook%2C+Beverly+D%3BDuhart%2C+Helen%3BNewport%2C+Glenn%3BAli%2C+Syed&rft.aulast=Tareke&rft.aufirst=Eden&rft.date=2009-07-17&rft.volume=458&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Neuroscience+Letters&rft.issn=03043940&rft_id=info:doi/10.1016%2Fj.neulet.2009.04.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Acrylamide DO - http://dx.doi.org/10.1016/j.neulet.2009.04.016 ER - TY - CPAPER T1 - The Regulatory Issues for Drug Development throughout the Pipeline T2 - 2009 Annual Conference of the Genetic Alliance AN - 40215958; 5194546 JF - 2009 Annual Conference of the Genetic Alliance AU - Kweder, Sandra Y1 - 2009/07/17/ PY - 2009 DA - 2009 Jul 17 KW - Pipelines KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40215958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+Genetic+Alliance&rft.atitle=The+Regulatory+Issues+for+Drug+Development+throughout+the+Pipeline&rft.au=Kweder%2C+Sandra&rft.aulast=Kweder&rft.aufirst=Sandra&rft.date=2009-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+Genetic+Alliance&rft.issn=&rft_id=info:doi/ L2 - http://geneticalliance.org/ws_display.asp?filter=conference09.program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Orphan Drug Act T2 - 2009 Annual Conference of the Genetic Alliance AN - 40215898; 5194545 JF - 2009 Annual Conference of the Genetic Alliance AU - Cote, Tim Y1 - 2009/07/17/ PY - 2009 DA - 2009 Jul 17 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40215898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Conference+of+the+Genetic+Alliance&rft.atitle=The+Orphan+Drug+Act&rft.au=Cote%2C+Tim&rft.aulast=Cote&rft.aufirst=Tim&rft.date=2009-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Conference+of+the+Genetic+Alliance&rft.issn=&rft_id=info:doi/ L2 - http://geneticalliance.org/ws_display.asp?filter=conference09.program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Genomic characterization of esophageal squamous cell carcinoma from a high-risk population in China. AN - 67496046; 19584285 AB - Genomic instability plays an important role in most human cancers. To characterize genomic instability in esophageal squamous cell carcinoma (ESCC), we examined loss of heterozygosity (LOH), copy number (CN) loss, CN gain, and gene expression using the Affymetrix GeneChip Human Mapping 500K (n = 30 cases) and Human U133A (n = 17 cases) arrays in ESCC cases from a high-risk region of China. We found that genomic instability measures varied widely among cases and separated them into two groups: a high-frequency instability group (two-thirds of all cases with one or more instability category of > or =10%) and a low-frequency instability group (one-third of cases with instability of <10%). Genomic instability also varied widely across chromosomal arms, with the highest frequency of LOH on 9p (33% of informative single nucleotide polymorphisms), CN loss on 3p (33%), and CN gain on 3q (48%). Twenty-two LOH regions were identified: four on 9p, seven on 9q, four on 13q, two on 17p, and five on 17q. Three CN loss regions-3p12.3, 4p15.1, and 9p21.3-were detected. Twelve CN gain regions were found, including six on 3q, one on 7q, four on 8q, and one on 11q. One of the most gene-rich of these CN gain regions was 11q13.1-13.4, where 26 genes also had RNA expression data available. CN gain was significantly correlated with increased RNA expression in over 80% of these genes. Our findings show the potential utility of combining CN analysis and gene expression data to identify genes involved in esophageal carcinogenesis. JF - Cancer research AU - Hu, Nan AU - Wang, Chaoyu AU - Ng, David AU - Clifford, Robert AU - Yang, Howard H AU - Tang, Ze-Zhong AU - Wang, Quan-Hong AU - Han, Xiao-You AU - Giffen, Carol AU - Goldstein, Alisa M AU - Taylor, Philip R AU - Lee, Maxwell P AD - Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892-7236, USA. Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 5908 EP - 5917 VL - 69 IS - 14 KW - RNA, Messenger KW - 0 KW - Index Medicus KW - Gene Frequency KW - Humans KW - Oligonucleotide Array Sequence Analysis -- methods KW - Aged KW - RNA, Messenger -- genetics KW - Asian Continental Ancestry Group -- genetics KW - Chromosome Mapping KW - Gene Expression Profiling KW - Loss of Heterozygosity KW - RNA, Messenger -- metabolism KW - Genomic Instability KW - Risk Factors KW - Adult KW - Chromosome Aberrations KW - Middle Aged KW - Gene Dosage KW - Male KW - China KW - Female KW - Carcinoma, Squamous Cell -- ethnology KW - Esophageal Neoplasms -- ethnology KW - Genome, Human -- genetics KW - Esophageal Neoplasms -- genetics KW - Carcinoma, Squamous Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67496046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Genomic+characterization+of+esophageal+squamous+cell+carcinoma+from+a+high-risk+population+in+China.&rft.au=Hu%2C+Nan%3BWang%2C+Chaoyu%3BNg%2C+David%3BClifford%2C+Robert%3BYang%2C+Howard+H%3BTang%2C+Ze-Zhong%3BWang%2C+Quan-Hong%3BHan%2C+Xiao-You%3BGiffen%2C+Carol%3BGoldstein%2C+Alisa+M%3BTaylor%2C+Philip+R%3BLee%2C+Maxwell+P&rft.aulast=Hu&rft.aufirst=Nan&rft.date=2009-07-15&rft.volume=69&rft.issue=14&rft.spage=5908&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-4622 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-25 N1 - Date created - 2009-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Genet. 2006 Nov;7(11):862-72 [17047685] Genes Chromosomes Cancer. 2006 Nov;45(11):1018-32 [16897747] Nat Genet. 2006 Dec;38(12):1386-96 [17099711] BMC Genomics. 2006;7:299 [17134496] Nat Genet. 2007 Feb;39(2):226-31 [17206142] Oncologist. 2007 Apr;12(4):406-17 [17470683] Oncol Rep. 2007 Aug;18(2):465-72 [17611672] Genes Chromosomes Cancer. 2008 Apr;47(4):353-62 [18196592] World J Gastroenterol. 2008 Mar 28;14(12):1828-35 [18350619] Int J Cancer. 2008 May 15;122(10):2249-54 [18241037] BMC Cancer. 2008;8:98 [18405350] Cancer Res. 2008 May 15;68(10):3558-60; discussion 3560-1 [18483234] Clin Cancer Res. 1999 Nov;5(11):3476-82 [10589761] Genes Chromosomes Cancer. 2000 Mar;27(3):217-28 [10679910] Carcinogenesis. 2000 Nov;21(11):2019-26 [11062163] Science. 2002 Aug 16;297(5584):1143 [12183620] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12963-8 [12297621] Bioinformatics. 2003 Jan 22;19(2):185-93 [12538238] Cancer Res. 2003 Jul 15;63(14):3872-6 [12873975] Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Feb;23(1):10-4 [12905809] Biostatistics. 2003 Apr;4(2):249-64 [12925520] Genes Chromosomes Cancer. 2004 Mar;39(3):205-16 [14732922] Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8715-20 [15155901] Natl Cancer Inst Monogr. 1982;62:113-20 [7167171] Science. 1996 Nov 8;274(5289):998-1001 [8875945] Nature. 1998 Dec 17;396(6712):643-9 [9872311] Genes Chromosomes Cancer. 1999 Apr;24(4):337-44 [10092132] Oncogene. 2005 Mar 3;24(10):1794-801 [15688027] Genes Chromosomes Cancer. 2005 Sep;44(1):37-51 [15929091] Genes Chromosomes Cancer. 2005 Nov;44(3):271-8 [16015646] Blood. 2006 Sep 1;108(5):1733-43 [16705090] Cancer Lett. 2008 Jul 8;265(2):157-66 [18406052] Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1424-35 [18559558] Int J Cancer. 2008 Oct 1;123(7):1610-5 [18649358] Genes Chromosomes Cancer. 2009 Jan;48(1):55-68 [18828157] J Pathol. 2008 Dec;216(4):471-82 [18798223] Genes Chromosomes Cancer. 2006 Nov;45(11):1033-40 [16897746] Dis Esophagus. 2006;19(6):459-67 [17069589] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-4622 ER - TY - JOUR T1 - Organohalogen and organophosphorous pesticide method for ginseng root--a comparison of gas chromatography-single quadrupole mass spectrometry with high resolution time-of-flight mass spectrometry. AN - 67486784; 19548696 AB - A method has been developed for the analysis of 170 organohalogen and organophosphorous pesticides, isomers, and metabolites in dried ground ginseng root. Pesticides were extracted with ethyl acetate and purified with gel permeation chromatography (GPC) and primary/secondary amine modified silica (PSA)/graphitized carbon black (GCB) combination SPE column. Each purified pesticide extract was determined by both gas chromatography single quadrupole mass spectrometry using selected ion monitoring (GC-qMS-SIM) and by gas chromatography high resolution time-of-flight mass spectrometry (GC-HR-TOFMS). The geometric mean LOQs using the qMS and TOFMS were 4 and 3 ng/g ginseng, respectively. Mean recoveries from ginseng were 83, 79, and 75% with standard deviations of 4, 5, and 3%, respectively, for 25, 100, and 500 ng/g using GC-qMS-SIM. Mean recoveries using GC-HR-TOFMS were 93, 85, and 81% with mean standard deviations of 7, 7, and 8% for 25, 100, and 500 ng/g, respectively. Seven dried ginseng root products were found to contain combinations of the following pesticides: dacthal, diazinon, DDT, hexachlorobenzene, iprodione, lindane, procymidone, and quintozene (1-460 ng/g). No significant differences were found in the concentrations measured for these pesticides on commercial ginsengs using either of the two GC/MS techniques. JF - Analytical chemistry AU - Hayward, Douglas G AU - Wong, Jon W AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, 5100 Paint Branch Parkway, HFS-706, College Park, Maryland 20740-5350, USA. douglas.hayward@fda.hhs.gov Y1 - 2009/07/15/ PY - 2009 DA - 2009 Jul 15 SP - 5716 EP - 5723 VL - 81 IS - 14 KW - Halogens KW - 0 KW - Organophosphorus Compounds KW - Pesticides KW - Index Medicus KW - Reproducibility of Results KW - Food Analysis KW - Isomerism KW - Pesticides -- chemistry KW - Pesticides -- analysis KW - Pesticides -- metabolism KW - Organophosphorus Compounds -- analysis KW - Panax -- chemistry KW - Organophosphorus Compounds -- metabolism KW - Mass Spectrometry -- methods KW - Organophosphorus Compounds -- chemistry KW - Plant Roots -- chemistry KW - Halogens -- chemistry KW - Chromatography, Gas -- methods KW - Pesticides -- isolation & purification KW - Organophosphorus Compounds -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67486784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+chemistry&rft.atitle=Organohalogen+and+organophosphorous+pesticide+method+for+ginseng+root--a+comparison+of+gas+chromatography-single+quadrupole+mass+spectrometry+with+high+resolution+time-of-flight+mass+spectrometry.&rft.au=Hayward%2C+Douglas+G%3BWong%2C+Jon+W&rft.aulast=Hayward&rft.aufirst=Douglas&rft.date=2009-07-15&rft.volume=81&rft.issue=14&rft.spage=5716&rft.isbn=&rft.btitle=&rft.title=Analytical+chemistry&rft.issn=1520-6882&rft_id=info:doi/10.1021%2Fac900494a LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-06 N1 - Date created - 2009-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ac900494a ER - TY - CPAPER T1 - FDA Investigation and Response to the Pet Food Outbreak T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40359738; 5270111 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Mcchesney, Daniel Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Outbreaks KW - Food contamination KW - FDA KW - Food KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=FDA+Investigation+and+Response+to+the+Pet+Food+Outbreak&rft.au=Mcchesney%2C+Daniel&rft.aulast=Mcchesney&rft.aufirst=Daniel&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Salmonella Persistence in Primary Production: The Example of Tomato-associated Salmonella in Virginia T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40359544; 5270057 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Hill, Thomas Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - USA, Virginia KW - Primary production KW - Anadromous species KW - Salmonella KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Salmonella+Persistence+in+Primary+Production%3A+The+Example+of+Tomato-associated+Salmonella+in+Virginia&rft.au=Hill%2C+Thomas&rft.aulast=Hill&rft.aufirst=Thomas&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adaptation of the Lateral Flow Immunochroma-tographic Hand-held System for the Detect- ion of Staphylococcal enterotoxin B (SEB or Staphylococcal enterotoxin C (SEC) in Commercial Infant Formulas, Baby Foods, Milk and Milk Products T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40358956; 5270003 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Njoroge, Joyce AU - Principato, Mary AU - Jones Jr, Robert AU - Boyle, Thomas Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Milk KW - Adaptability KW - Infant formulas KW - Adaptations KW - Staphylococcal enterotoxin C KW - Food KW - Milk products KW - Staphylococcal enterotoxin B KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40358956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Adaptation+of+the+Lateral+Flow+Immunochroma-tographic+Hand-held+System+for+the+Detect-+ion+of+Staphylococcal+enterotoxin+B+%28SEB+or+Staphylococcal+enterotoxin+C+%28SEC%29+in+Commercial+Infant+Formulas%2C+Baby+Foods%2C+Milk+and+Milk+Products&rft.au=Njoroge%2C+Joyce%3BPrincipato%2C+Mary%3BJones+Jr%2C+Robert%3BBoyle%2C+Thomas&rft.aulast=Njoroge&rft.aufirst=Joyce&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Molecular Detection Methods for Vibrio spp. in Oysters T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40357198; 5269976 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Jones, Jessica AU - Hara-Kudo, Yukiko AU - Krantz, Jeffrey AU - Smith, Amy AU - Dambaugh, Timothy AU - DePaola, Angelo Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Oysters KW - Disease detection KW - Pathogenic bacteria KW - Vibrio KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40357198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Comparison+of+Molecular+Detection+Methods+for+Vibrio+spp.+in+Oysters&rft.au=Jones%2C+Jessica%3BHara-Kudo%2C+Yukiko%3BKrantz%2C+Jeffrey%3BSmith%2C+Amy%3BDambaugh%2C+Timothy%3BDePaola%2C+Angelo&rft.aulast=Jones&rft.aufirst=Jessica&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Listeria monocytogenes Isolates of Imported Cheese Contributed to the National PulseNet Database by the FDA from 2001 to 2008 T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40356446; 5269992 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Timbo, Babgaleh AU - Keys, Christine AU - Klontz, Karl Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Dairy products KW - Food contamination KW - FDA KW - Cheese KW - Databases KW - Listeria monocytogenes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Characterization+of+Listeria+monocytogenes+Isolates+of+Imported+Cheese+Contributed+to+the+National+PulseNet+Database+by+the+FDA+from+2001+to+2008&rft.au=Timbo%2C+Babgaleh%3BKeys%2C+Christine%3BKlontz%2C+Karl&rft.aulast=Timbo&rft.aufirst=Babgaleh&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of FDA Draft Document Guidelines for the Control of Listeria monocytogenes in Refrigerated or Frozen Ready-to-Eat Foods T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40354270; 5270071 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Losikoff, Mary Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Guidelines KW - FDA KW - Reviews KW - Frozen food KW - Listeria monocytogenes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Overview+of+FDA+Draft+Document+Guidelines+for+the+Control+of+Listeria+monocytogenes+in+Refrigerated+or+Frozen+Ready-to-Eat+Foods&rft.au=Losikoff%2C+Mary&rft.aulast=Losikoff&rft.aufirst=Mary&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hepatitis A Virus Survival during Low Heat Dehydration of Green Onion T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40354085; 5270024 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Laird, David AU - Reineke, K AU - Shieh, Y Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Survival KW - Hepatitis A KW - Dehydration KW - Heat KW - Hepatitis A virus KW - Allium cepa KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Hepatitis+A+Virus+Survival+during+Low+Heat+Dehydration+of+Green+Onion&rft.au=Laird%2C+David%3BReineke%2C+K%3BShieh%2C+Y&rft.aulast=Laird&rft.aufirst=David&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Salmonella Saintpaul in Tomatoes/Peppers; Environmental Investigation Lessons Learned T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40354063; 5270115 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Mcgarry, Sherri Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Anadromous species KW - Lycopersicon esculentum KW - Salmonella KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Salmonella+Saintpaul+in+Tomatoes%2FPeppers%3B+Environmental+Investigation+Lessons+Learned&rft.au=Mcgarry%2C+Sherri&rft.aulast=Mcgarry&rft.aufirst=Sherri&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Different Pre-enrichment Strategies for the Recovery of Salmonella from Internally Contaminated Red Round Tomatoes T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40353995; 5270098 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Russell, Mindi AU - Jacobson, Andrew AU - Hammack, Thomas Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Anadromous species KW - Lycopersicon esculentum KW - Salmonella KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40353995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Comparison+of+Different+Pre-enrichment+Strategies+for+the+Recovery+of+Salmonella+from+Internally+Contaminated+Red+Round+Tomatoes&rft.au=Russell%2C+Mindi%3BJacobson%2C+Andrew%3BHammack%2C+Thomas&rft.aulast=Russell&rft.aufirst=Mindi&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Implications of Persistence in the Processing Environment, the Product, and Primary Production T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40353872; 5270060 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Zink, Don Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Primary production KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40353872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Regulatory+Implications+of+Persistence+in+the+Processing+Environment%2C+the+Product%2C+and+Primary+Production&rft.au=Zink%2C+Don&rft.aulast=Zink&rft.aufirst=Don&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Surface Allergen Testing Methods T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40352023; 5270126 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Jackson, Lauren Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Allergens KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40352023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Surface+Allergen+Testing+Methods&rft.au=Jackson%2C+Lauren&rft.aulast=Jackson&rft.aufirst=Lauren&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved Enrichment of Shigella spp. in Produce T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40351660; 5269987 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Grant, Michael AU - Wetherington, June AU - Lampel, Keith AU - Deer, Deanne Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Shigella KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Improved+Enrichment+of+Shigella+spp.+in+Produce&rft.au=Grant%2C+Michael%3BWetherington%2C+June%3BLampel%2C+Keith%3BDeer%2C+Deanne&rft.aulast=Grant&rft.aufirst=Michael&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Climate Change on Bacterial Pathogens T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40351176; 5270075 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Depaola, Angelo Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Climatic changes KW - Pathogens KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Effects+of+Climate+Change+on+Bacterial+Pathogens&rft.au=Depaola%2C+Angelo&rft.aulast=Depaola&rft.aufirst=Angelo&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Versatile Internal Control for DNA and RNA Real-time PCR Assays T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40351009; 5270161 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Deer, Deanne AU - Gonzalez-Escalona, Narjol AU - Chen, Yi AU - Lampel, Keith Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Polymerase chain reaction KW - RNA KW - Nucleic acids KW - Nucleotide sequence KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=A+Versatile+Internal+Control+for+DNA+and+RNA+Real-time+PCR+Assays&rft.au=Deer%2C+Deanne%3BGonzalez-Escalona%2C+Narjol%3BChen%2C+Yi%3BLampel%2C+Keith&rft.aulast=Deer&rft.aufirst=Deanne&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How We Got Here with Regulations of Vibrio vulnificus and Vibrio parahaemolyticus and Risk Calculator T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40350947; 5270129 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Depaola, Angelo Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Calculators KW - Vibrio parahaemolyticus KW - Vibrio vulnificus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40350947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=How+We+Got+Here+with+Regulations+of+Vibrio+vulnificus+and+Vibrio+parahaemolyticus+and+Risk+Calculator&rft.au=Depaola%2C+Angelo&rft.aulast=Depaola&rft.aufirst=Angelo&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Research Aimed at Minimizing an Increase in Contamination Levels T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40350673; 5270321 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Tortorello, Mary Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Contamination KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40350673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Research+Aimed+at+Minimizing+an+Increase+in+Contamination+Levels&rft.au=Tortorello%2C+Mary&rft.aulast=Tortorello&rft.aufirst=Mary&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Allergen-specific (ELISA) and Non-specific (Visual Inspection, ATP Swabs, Total Protein Swabs) Methods for the Detection of Soy-based Food Residues T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40349235; 5270245 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Jackson, Lauren AU - Al-Taher, Fadwa Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Inspection KW - Residues KW - ATP KW - ELISA KW - Food hypersensitivity KW - Visual inspection KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40349235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Comparison+of+Allergen-specific+%28ELISA%29+and+Non-specific+%28Visual+Inspection%2C+ATP+Swabs%2C+Total+Protein+Swabs%29+Methods+for+the+Detection+of+Soy-based+Food+Residues&rft.au=Jackson%2C+Lauren%3BAl-Taher%2C+Fadwa&rft.aulast=Jackson&rft.aufirst=Lauren&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analytical Methods: The Needs, the Reality and the Perspectives T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40347687; 5270469 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Feng, Peter Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Analytical+Methods%3A+The+Needs%2C+the+Reality+and+the+Perspectives&rft.au=Feng%2C+Peter&rft.aulast=Feng&rft.aufirst=Peter&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epidemiology of Multistate Foodborne Outbreaks, United States: 1998 to 2007 T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40347512; 5270402 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Gray, Stephani AU - Ayers, Tracy AU - Grass, Julian AU - Williams, Ian Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - USA KW - Food-borne diseases KW - Food KW - Epidemiology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Epidemiology+of+Multistate+Foodborne+Outbreaks%2C+United+States%3A+1998+to+2007&rft.au=Gray%2C+Stephani%3BAyers%2C+Tracy%3BGrass%2C+Julian%3BWilliams%2C+Ian&rft.aulast=Gray&rft.aufirst=Stephani&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Managing Chemical Contaminants in Food T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40346980; 5270328 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Beru, Nega Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Chemical pollution KW - Food contamination KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Managing+Chemical+Contaminants+in+Food&rft.au=Beru%2C+Nega&rft.aulast=Beru&rft.aufirst=Nega&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Food Commodities Associated with Salmonella Enteritidis Outbreaks 1998-2007 T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40346879; 5270302 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - PeRez, Alejandro AU - Ayers, Tracy AU - Williams, Ian AU - Swerdlow, David Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Outbreaks KW - Food contamination KW - Food KW - Anadromous species KW - Salmonella enteritidis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Food+Commodities+Associated+with+Salmonella+Enteritidis+Outbreaks+1998-2007&rft.au=PeRez%2C+Alejandro%3BAyers%2C+Tracy%3BWilliams%2C+Ian%3BSwerdlow%2C+David&rft.aulast=PeRez&rft.aufirst=Alejandro&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Potential for Application of the Key Events Dose-response Framework (KEDRF) to Foodborne Allergens T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40346784; 5270290 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Gendel, Steven Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Dose-response effects KW - Allergens KW - Food KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Potential+for+Application+of+the+Key+Events+Dose-response+Framework+%28KEDRF%29+to+Foodborne+Allergens&rft.au=Gendel%2C+Steven&rft.aulast=Gendel&rft.aufirst=Steven&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Commercial RNA Extraction Kits for Preparation of DNA-free Total RNA from Salmonella Cells T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40343418; 5270173 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Gonzalez-Escalona, Narjol AU - Asamoah, Benedicta Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - RNA KW - Anadromous species KW - Salmonella KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Comparison+of+Commercial+RNA+Extraction+Kits+for+Preparation+of+DNA-free+Total+RNA+from+Salmonella+Cells&rft.au=Gonzalez-Escalona%2C+Narjol%3BAsamoah%2C+Benedicta&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vulnerabilities and Mitigations T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40342115; 5270470 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Kautter, Donald Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Vulnerability KW - Mitigation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Vulnerabilities+and+Mitigations&rft.au=Kautter%2C+Donald&rft.aulast=Kautter&rft.aufirst=Donald&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biogenic Amine Production in Yellowfin Tuna (Thunnus albacares) under Controlled Decomposition Conditions T2 - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AN - 40341208; 5269972 JF - 96th Annual Meeting of the International Association for Food Protection (IAFP 2009) AU - Benner, Ronald AU - Staruszkiewicz, Walter AU - Conrad, Stephen AU - Samuels, Robert Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Amines KW - Decomposition KW - Biogenic amines KW - Biodegradation KW - Marine fish KW - Thunnus albacares KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.atitle=Biogenic+Amine+Production+in+Yellowfin+Tuna+%28Thunnus+albacares%29+under+Controlled+Decomposition+Conditions&rft.au=Benner%2C+Ronald%3BStaruszkiewicz%2C+Walter%3BConrad%2C+Stephen%3BSamuels%2C+Robert&rft.aulast=Benner&rft.aufirst=Ronald&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://foodprotection.org/files/annual_meeting/full-program-2009.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In-Situ Fatigue Test of a36-Steel T2 - 12th International Conference on Fracture (ICF 12) AN - 40185036; 5176167 JF - 12th International Conference on Fracture (ICF 12) AU - Yamagiwa, K AU - Hoeppner, D Y1 - 2009/07/12/ PY - 2009 DA - 2009 Jul 12 KW - Fatigue KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40185036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Conference+on+Fracture+%28ICF+12%29&rft.atitle=In-Situ+Fatigue+Test+of+a36-Steel&rft.au=Yamagiwa%2C+K%3BHoeppner%2C+D&rft.aulast=Yamagiwa&rft.aufirst=K&rft.date=2009-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Conference+on+Fracture+%28ICF+12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icf12.com/doc-pdf/Program/ICF-program_detail.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Prevention of Salmonella enteritidis in shell eggs during production, storage, and transportation. Final rule. AN - 67468086; 19588581 AB - The Food and Drug Administration (FDA) is issuing a final rule that requires shell egg producers to implement measures to prevent Salmonella Enteritidis (SE) from contaminating eggs on the farm and from further growth during storage and transportation, and requires these producers to maintain records concerning their compliance with the rule and to register with FDA. FDA is taking this action because SE is among the leading bacterial causes of foodborne illness in the United States, and shell eggs are a primary source of human SE infections. The final rule will reduce SE-associated illnesses and deaths by reducing the risk that shell eggs are contaminated with SE. JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2009/07/09/ PY - 2009 DA - 2009 Jul 09 SP - 33029 EP - 33101 VL - 74 IS - 130 SN - 0097-6326, 0097-6326 KW - Health technology assessment KW - United States KW - Pest Control -- legislation & jurisprudence KW - Environmental Monitoring -- legislation & jurisprudence KW - Animals KW - Disease Vectors KW - United States Food and Drug Administration KW - Forms and Records Control -- legislation & jurisprudence KW - Humans KW - Cost-Benefit Analysis KW - Poultry -- microbiology KW - Quality Control KW - Disinfection -- legislation & jurisprudence KW - Chickens -- microbiology KW - Salmonella Infections -- prevention & control KW - Salmonella enteritidis -- pathogenicity KW - Salmonella Infections -- microbiology KW - Legislation, Food KW - Food Contamination -- prevention & control KW - Egg Shell -- microbiology KW - Eggs -- microbiology KW - Food Handling -- legislation & jurisprudence KW - Food Microbiology -- legislation & jurisprudence KW - Food Industry -- legislation & jurisprudence KW - Food Contamination -- legislation & jurisprudence KW - Consumer Product Safety -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67468086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Prevention+of+Salmonella+enteritidis+in+shell+eggs+during+production%2C+storage%2C+and+transportation.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2009-07-09&rft.volume=74&rft.issue=130&rft.spage=33029&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-20 N1 - Date created - 2009-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The FDA Approach to Antibiotics for the Treatment of Clostridium difficile- Associated Disease T2 - 10th Biennial Congress of the Anaerobe Society of the Americas (Anaerobe 2010) AN - 866037221; 5973986 JF - 10th Biennial Congress of the Anaerobe Society of the Americas (Anaerobe 2010) AU - Marsik, Frederic Y1 - 2009/07/07/ PY - 2009 DA - 2009 Jul 07 KW - Antibiotics KW - FDA KW - Disease control KW - Clostridium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866037221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Biennial+Congress+of+the+Anaerobe+Society+of+the+Americas+%28Anaerobe+2010%29&rft.atitle=The+FDA+Approach+to+Antibiotics+for+the+Treatment+of+Clostridium+difficile-+Associated+Disease&rft.au=Marsik%2C+Frederic&rft.aulast=Marsik&rft.aufirst=Frederic&rft.date=2009-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Biennial+Congress+of+the+Anaerobe+Society+of+the+Americas+%28Anaerobe+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.anaerobe.org/2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - JOUR T1 - Intake of meat, meat mutagens, and iron and the risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial AN - 20936512; 10986146 AB - Background:Epidemiological evidence on meat intake and breast cancer is inconsistent, with little research on potentially carcinogenic meat-related exposures. We investigated meat subtypes, cooking practices, meat mutagens, iron, and subsequent breast cancer risk. Methods:Among 52158 women (aged 55-74 years) in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, who completed a food frequency questionnaire, 1205 invasive breast cancer cases were identified. We estimated meat mutagen and haem iron intake with databases accounting for cooking practices. Using Cox proportional hazards regression, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) within quintiles of intake. Results:Comparing the fifth to the first quintile, red meat (HR=1.23; 95% CI=1.00-1.51, P trend=0.22), the heterocyclic amine (HCA), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), (HR=1.26; 95% CI=1.03-1.55; P trend=0.12), and dietary iron (HR=1.25; 95% CI=1.02-1.52; P trend=0.03) were positively associated with breast cancer. We observed elevated, though not statistically significant, risks with processed meat, the HCA 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), mutagenic activity, iron from meat, and haem iron from meat. Conclusion:In this prospective study, red meat, MeIQx, and dietary iron elevated the risk of invasive breast cancer, but there was no linear trend in the association except for dietary iron.British Journal of Cancer (2009) 101, 178-184; doi:10.1038/sj.bjc.6605118 www.bjcancer.com Published online online 9 June 2009 JF - British Journal of Cancer AU - Ferrucci, L M AU - Cross, A J AU - Graubard, B I AU - Brinton, L A AU - McCarty, C A AU - Ziegler, R G AU - Ma, X AU - Mayne, S T AU - Sinha, R AD - [1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD 20852, USA [2] Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA Y1 - 2009/07/07/ PY - 2009 DA - 2009 Jul 07 SP - 178 EP - 184 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 101 IS - 1 SN - 0007-0920, 0007-0920 KW - Toxicology Abstracts; Risk Abstracts KW - Heterocyclic amines KW - Mutagens KW - Invasiveness KW - Food KW - Statistical analysis KW - Cooking KW - cooking KW - Diets KW - Inventories KW - Ovarian cancer KW - ovarian carcinoma KW - Amines KW - Meat KW - Databases KW - Lung KW - Breast cancer KW - Prostate KW - Iron KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20936512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Intake+of+meat%2C+meat+mutagens%2C+and+iron+and+the+risk+of+breast+cancer+in+the+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial&rft.au=Ferrucci%2C+L+M%3BCross%2C+A+J%3BGraubard%2C+B+I%3BBrinton%2C+L+A%3BMcCarty%2C+C+A%3BZiegler%2C+R+G%3BMa%2C+X%3BMayne%2C+S+T%3BSinha%2C+R&rft.aulast=Ferrucci&rft.aufirst=L&rft.date=2009-07-07&rft.volume=101&rft.issue=1&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605118 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mutagens; Ovarian cancer; Inventories; Heterocyclic amines; Invasiveness; Food; Statistical analysis; Meat; Databases; Cooking; Breast cancer; Iron; Prostate; Diets; Lung; ovarian carcinoma; cooking; Amines DO - http://dx.doi.org/10.1038/sj.bjc.6605118 ER - TY - CPAPER T1 - Modeling Ultrasound Scattering from Cancellous Bone T2 - 2009 Annual Meeting of the Society for Industrial and Applied Mathematics AN - 40249686; 5214794 JF - 2009 Annual Meeting of the Society for Industrial and Applied Mathematics AU - Wear, Keith Y1 - 2009/07/06/ PY - 2009 DA - 2009 Jul 06 KW - Bone (cancellous) KW - Ultrasound KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40249686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Society+for+Industrial+and+Applied+Mathematics&rft.atitle=Modeling+Ultrasound+Scattering+from+Cancellous+Bone&rft.au=Wear%2C+Keith&rft.aulast=Wear&rft.aufirst=Keith&rft.date=2009-07-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Society+for+Industrial+and+Applied+Mathematics&rft.issn=&rft_id=info:doi/ L2 - http://meetings.siam.org/program.cfm?CONFCODE=AN09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drug Interaction Information in Product Labels - After the evolution, is it time for a revolution? T2 - 2009 Gordon Research Conference on Drug Metabolism AN - 40294996; 5241295 JF - 2009 Gordon Research Conference on Drug Metabolism AU - Reynolds, Kellie Y1 - 2009/07/05/ PY - 2009 DA - 2009 Jul 05 KW - Drug interaction KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40294996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Drug+Metabolism&rft.atitle=Drug+Interaction+Information+in+Product+Labels+-+After+the+evolution%2C+is+it+time+for+a+revolution%3F&rft.au=Reynolds%2C+Kellie&rft.aulast=Reynolds&rft.aufirst=Kellie&rft.date=2009-07-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Drug+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=drugmet LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Temperature modes for nonlinear Gaussian beams. AN - 742777443; pmid-19603899 AB - In assessing the influence of nonlinear acoustic propagation on thermal bioeffects, approximate methods for quickly estimating the temperature rise as operational parameters are varied can be very useful. This paper provides a formula for the transient temperature rise associated with nonlinear propagation of Gaussian beams. The pressure amplitudes for the Gaussian modes can be obtained rapidly using a method previously published for simulating nonlinear propagation of Gaussian beams. The temperature-mode series shows that the nth temperature mode generated by nonlinear propagation, when normalized by the fundamental, is weaker than the nth heat-rate mode (also normalized by the fundamental in the heat-rate series) by a factor of log(n)/n, where n is the mode number. Predictions of temperature rise and thermal dose were found to be in close agreement with full, finite-difference calculations of the pressure fields, temperature rise, and thermal dose. Applications to non-Gaussian beams were made by fitting the main lobe of the significant modes to Gaussian functions. JF - The Journal of the Acoustical Society of America AU - Myers, Matthew R AU - Soneson, Joshua E AD - Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 425 EP - 433 VL - 126 IS - 1 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Hot Temperature KW - Acoustics KW - Algorithms KW - Diffusion KW - Fourier Analysis KW - Pressure KW - Time Factors KW - Ultrasonics KW - Normal Distribution KW - Temperature KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742777443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Temperature+modes+for+nonlinear+Gaussian+beams.&rft.au=Myers%2C+Matthew+R%3BSoneson%2C+Joshua+E&rft.aulast=Myers&rft.aufirst=Matthew&rft.date=2009-07-01&rft.volume=126&rft.issue=1&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: predictive tests and biomarkers. AN - 733360645; 19558236 AB - The most attractive properties of engineered nanomaterials for technological applications, including their small size, large surface area, and high reactivity, are also the main factors for their potential toxicity. Based on ambient ultrafine particle research, it is predicted that nanosized particles may have deeper pulmonary deposition, higher biological activity, and a tendency for extrapulmonary translocation compared to larger particles. In this regard, nanoparticle exposure, by direct or indirect mechanisms, may lead to unexpected distant responses, involving the immune system, cardiovascular system, liver, kidney, and brain. The systemic effects may induce or modify the progression of existing diseases such as cardiovascular disease. Current experimental toxicity evaluation of engineered nanomaterials, specifically carbon nanotubes, demonstrated that deposition of these materials in the lung leads to inflammation and fibrosis. The local toxicity is associated with cardiovascular effects related to atherosclerosis. Although translocation of carbon nanotubes into the systemic circulation is hypothetically possible, there is no current evidence to support this hypothesis. However, studies pointed out that carbon nanotube-induced lung inflammation results in a release of inflammatory mediators and activation of blood cells which can contribute to cardiovascular adverse effects. Furthermore, complex protein and gene expression blood analysis can help in development of biomarkers for application in human screening of nanoparticle exposure. Future studies to evaluate the systemic effects of carbon nanotube exposure under workplace or environmental exposure paradigms should be conducted. JF - Inhalation toxicology AU - Simeonova, Petia P AU - Erdely, Aaron AD - Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. PSimeonova@cdc.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 68 EP - 73 VL - 21 Suppl 1 KW - Air Pollutants KW - 0 KW - Biomarkers KW - Nanotubes, Carbon KW - Index Medicus KW - Environmental Monitoring KW - Animals KW - Reproducibility of Results KW - Humans KW - Biomarkers -- metabolism KW - Risk Assessment KW - Air Pollutants -- metabolism KW - Inhalation Exposure KW - Toxicity Tests KW - Lung -- drug effects KW - Cardiovascular System -- metabolism KW - Cardiovascular Diseases -- metabolism KW - Cardiovascular System -- drug effects KW - Cardiovascular Diseases -- chemically induced KW - Lung -- metabolism KW - Air Pollutants -- toxicity KW - Nanotubes, Carbon -- toxicity KW - Nanoparticles -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733360645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Engineered+nanoparticle+respiratory+exposure+and+potential+risks+for+cardiovascular+toxicity%3A+predictive+tests+and+biomarkers.&rft.au=Simeonova%2C+Petia+P%3BErdely%2C+Aaron&rft.aulast=Simeonova&rft.aufirst=Petia&rft.date=2009-07-01&rft.volume=21+Suppl+1&rft.issue=&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958370902942566 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-01 N1 - Date created - 2009-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08958370902942566 ER - TY - JOUR T1 - Rapid method for the determination and confirmation of fluoroquinolone residues in catfish using liquid chromatography/fluorescence detection and liquid chromatography-tandem mass spectrometry. AN - 67616743; 19714995 AB - A simplified method for the extraction and determination of four fluoroquinolone (FQ) residues (ciprofloxacin, enrofloxacin, sarafloxacin, and difloxacin) in catfish is presented. In this method, the FQ residues were extracted with acidified acetonitrile, and the extract was defatted with dispersive C18 solid-phase extraction (SPE) sorbent or hexane. A portion of the extract was evaporated and reconstituted in the mobile phase. The quantitative determination was accomplished with LC-fluorescence detection (FLD), and the confirmation was by LC-MS/MS. Fortifications of catfish tissue were carried out at 0.5x, x, 2x, and 4x, where x = 5 ppb (U.S. Food and Drug Administration current regulatory target level). Recoveries for the LC/FLD determination of five replicates (for both cleanup routes) at each level ranged from 64 to 98%, with RSD values <8%. The method quantitation limits for all residues were <1 ng/g. The LC-MS/MS analysis of the same extracts confirmed all FQ residues at all levels. This method is an improvement over existing methodologies since additional cleanup steps, such as cation exchange SPE column cleanup, are not utilized. The C18 dispersive SPE method represents a novel cleanup approach for FQs in fish tissue. JF - Journal of AOAC International AU - McMullen, Sarah E AU - Schenck, Frank J AU - Vega, Victor A AD - U.S. Food and Drug Administration, Southeast Regional Laboratory, 60 Eighth St NE, Atlanta, GA 30309, USA. sarah.mcmullen@fda.hhs.gov PY - 2009 SP - 1233 EP - 1240 VL - 92 IS - 4 SN - 1060-3271, 1060-3271 KW - Anti-Bacterial Agents KW - 0 KW - Fluoroquinolones KW - Hexanes KW - Indicators and Reagents KW - Solutions KW - Solvents KW - Index Medicus KW - Animals KW - Spectrometry, Fluorescence KW - Reference Standards KW - Tandem Mass Spectrometry KW - Solid Phase Extraction KW - Chromatography, High Pressure Liquid KW - Fluoroquinolones -- analysis KW - Drug Residues -- analysis KW - Anti-Bacterial Agents -- analysis KW - Catfishes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67616743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Rapid+method+for+the+determination+and+confirmation+of+fluoroquinolone+residues+in+catfish+using+liquid+chromatography%2Ffluorescence+detection+and+liquid+chromatography-tandem+mass+spectrometry.&rft.au=McMullen%2C+Sarah+E%3BSchenck%2C+Frank+J%3BVega%2C+Victor+A&rft.aulast=McMullen&rft.aufirst=Sarah&rft.date=2009-07-01&rft.volume=92&rft.issue=4&rft.spage=1233&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-24 N1 - Date created - 2009-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of tricaine residues in fish by liquid chromatography. AN - 67615628; 19714996 AB - Tricaine methanesulfonate (MS-222) is approved by the U.S. Food and Drug Administration, Center for Veterinary Medicine (CVM), as an anesthetic drug for select aquaculture species. It was approved for use as a handling aid with a 3 week withdrawal time. The drug is rapidly metabolized and excreted; therefore, CVM approved its use without requiring a regulatory method for drug residues in tissues. However, there are concerns that the drug may be used to sedate fish during transport to slaughter. A regulatory method will enable monitoring for unsafe residues of this drug resulting from extralabel use. We present a quantitative method, using LC at a target level of 0.1 mg/kg (ppm), for three different farmed species: salmon (Salmo salar); tilapia (Oreochromis spp.); and catfish (Ictalurus punctatus). The assay begins with an acetonitrile extraction, followed by filtration and mixed-mode cation-exchange solid-phase extraction cleanup. The extracts are analyzed by reversed-phase LC with UV detection at 320 nm. The method was validated by using fish fillets with incurred residues, control fish fillets, and fish fillets fortified at half the target level, the target level, and twice the target level (0.05, 0.1, and 0.2 ppm, respectively). For all species, accuracy is > or =80% and the RSD is < or =10%. The method complies with CVM performance criteria for the determination of veterinary drug residues. JF - Journal of AOAC International AU - Nochetto, Cristina B AU - Reimschuessel, Renate AU - Gieseker, Charles AU - Cheely, Christie-Sue AU - Carson, Mary C AD - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd, Laurel, MD 20708, USA. cristina.nochetto@fda.hhs.gov PY - 2009 SP - 1241 EP - 1247 VL - 92 IS - 4 SN - 1060-3271, 1060-3271 KW - Aminobenzoates KW - 0 KW - Anesthetics KW - Solutions KW - tricaine KW - 02591PHL19 KW - Index Medicus KW - Animals KW - Reproducibility of Results KW - Biotransformation KW - Reference Standards KW - Calibration KW - Solid Phase Extraction KW - Quality Control KW - Chromatography, High Pressure Liquid KW - Anesthetics -- analysis KW - Anesthetics -- pharmacokinetics KW - Drug Residues -- analysis KW - Aminobenzoates -- analysis KW - Aminobenzoates -- pharmacokinetics KW - Fishes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67615628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determination+of+tricaine+residues+in+fish+by+liquid+chromatography.&rft.au=Nochetto%2C+Cristina+B%3BReimschuessel%2C+Renate%3BGieseker%2C+Charles%3BCheely%2C+Christie-Sue%3BCarson%2C+Mary+C&rft.aulast=Nochetto&rft.aufirst=Cristina&rft.date=2009-07-01&rft.volume=92&rft.issue=4&rft.spage=1241&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-24 N1 - Date created - 2009-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preferences of minipigs for environmental enrichment objects. AN - 67554242; 19653948 AB - The minipig is an increasingly popular species for use in behavioral and toxicologic studies. As a result, quantification of environmental enrichment preferences for this species is especially important. We exposed 6 individually housed prepubertal female Yucatan minipigs to 1 of 3 different objects on a rotating schedule: 2 sessions with a hard plastic ball (diameter, 21.0 cm), and 3 sessions each with a large plastic apple (diameter, 22.5 cm) and a soft rubber cone (height, 48.0 cm). Objects were changed every 4 to 5 d. The initial 15 min after each object change was recorded, and duration of object interaction and other behaviors (activity and interaction with the food bowl) were measured. Results indicated significantly longer interactions with the cone (mean +/- SE, 282 +/- 54 s) than the ball (14 +/- 3 s). Interactions with the apple (66 +/- 18 s) and ball did not differ significantly. Interactions with the apple decreased across the 3 sessions, whereas interaction with the cone remained high for most minipigs over the 3 sessions. Duration of activity appeared to be inversely correlated with duration of object interaction (that is, the longer the subject interacted with the object, the less it engaged in nonobject activity). These results provide valuable and practical information on the features of objects that minipigs appear to prefer and offer suggestions for future studies evaluating environmental enrichment paradigms with individually housed minipigs. JF - Journal of the American Association for Laboratory Animal Science : JAALAS AU - Smith, Melody E AU - Gopee, Neera V AU - Ferguson, Sherry A AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 391 EP - 394 VL - 48 IS - 4 SN - 1559-6109, 1559-6109 KW - Index Medicus KW - Swine KW - Animals KW - Olfactory Pathways -- physiology KW - Female KW - Environment KW - Swine, Miniature -- physiology KW - Choice Behavior -- physiology KW - Behavior, Animal -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67554242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.atitle=Preferences+of+minipigs+for+environmental+enrichment+objects.&rft.au=Smith%2C+Melody+E%3BGopee%2C+Neera+V%3BFerguson%2C+Sherry+A&rft.aulast=Smith&rft.aufirst=Melody&rft.date=2009-07-01&rft.volume=48&rft.issue=4&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.issn=15596109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-23 N1 - Date created - 2009-08-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lab Anim. 1999 Oct;33(4):309-27 [10778780] Neural Plast. 2002;9(4):255-9 [12959155] ILAR J. 2005;46(2):148-61 [15775024] Behav Processes. 2009 Jan;80(1):28-34 [18804519] ILAR J. 2006;47(4):358-63 [16963815] Lab Anim (NY). 2007 Mar;36(3):32-4 [17311047] Neurosci Biobehav Rev. 2007;31(5):728-51 [17445892] ILAR J. 2005;46(2):178-91 [15775027] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Formative research in occupational health and safety intervention for diverse, underserved worker populations: a homecare worker intervention project. AN - 67507765; 19618810 AB - OBJECTIVE The increasing numbers of minority, low-income, and contingent workers in the U.S. labor force present new challenges to occupational safety and health interventions. Formative research can be used to help researchers better understand target populations and identify unanticipated barriers to safety changes. The National Institute for Occupational Safety and Health initiated an intervention project to improve health and safety among homecare workers in Alameda County, California. Investigators conducted systematic formative research to gather information to guide intervention development. METHODS Various qualitative methods were used including 11 focus groups (conducted in English, Spanish, and Chinese) and 10 key informant interviews. This article focuses on two picture-based focus group activities that explored workers' views on their relationships with consumers and their perceived barriers to interventions. RESULTS Findings indicated cultural differences regarding workers' perceptions of their relationships with consumers. Chinese homecare workers mostly focused on respecting elders rather than initiating changes. Some English- and Spanish-speaking workers described efforts to negotiate with consumers. Results also identified workers' perceived barriers to interventions, such as consumers' resistance to changes and lack of resources. These findings played important roles in shaping the intervention materials. For example, given the lack of resources among consumers, the project tried to tap into community-level resources by collaborating with local stakeholders and developing community resource guides. CONCLUSION Formative research can be a valuable step to inform the development of occupational health and safety interventions for diverse, underserved worker populations. JF - Public health reports (Washington, D.C. : 1974) AU - Gong, Fang AU - Baron, Sherry AU - Ayala, Linda AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Pkwy., MS R-17, Cincinnati, OH 45226, USA. PY - 2009 SP - 84 EP - 89 VL - 124 Suppl 1 SN - 0033-3549, 0033-3549 KW - Abridged Index Medicus KW - Index Medicus KW - California KW - Humans KW - Safety KW - Medically Underserved Area KW - Health Services Research KW - Community Participation KW - Needs Assessment KW - Cultural Diversity KW - Accidents, Occupational -- prevention & control KW - Home Health Aides KW - Occupational Health Services -- organization & administration KW - Occupational Health Services -- methods KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67507765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Formative+research+in+occupational+health+and+safety+intervention+for+diverse%2C+underserved+worker+populations%3A+a+homecare+worker+intervention+project.&rft.au=Gong%2C+Fang%3BBaron%2C+Sherry%3BAyala%2C+Linda&rft.aulast=Gong&rft.aufirst=Fang&rft.date=2009-07-01&rft.volume=124+Suppl+1&rft.issue=&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-27 N1 - Date created - 2009-07-21 N1 - Date revised - 2017-02-15 N1 - SuppNotes - Cited By: Health Aff (Millwood). 2001 Nov-Dec;20(6):80-95 [11816693] Am J Health Behav. 2005 Jan-Feb;29(1):57-69 [15604050] J Cross Cult Gerontol. 2004 Dec;19(4):299-319 [15604646] JAMA. 2008 Jan 30;299(4):448-50 [18230783] Health Educ Behav. 2006 Feb;33(1):97-111 [16397162] Obesity (Silver Spring). 2007 Nov;15 Suppl 1:37S-47S [18073340] Gerontologist. 2005 Oct;45(5):593-600 [16199393] N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Efficacy of a program to prevent beryllium sensitization among new employees at a copper-beryllium alloy processing facility. AN - 67504792; 19618813 AB - OBJECTIVES In 2000, 7% of workers at a copper-beryllium facility were beryllium sensitized. Risk was associated with work near a wire annealing/pickling process. The facility then implemented a preventive program including particle migration control, respiratory and dermal protection, and process enclosure. We assessed the program's efficacy in preventing beryllium sensitization. METHODS In 2000, the facility began testing new hires (program workers) with beryllium lymphocyte proliferation tests (BeLPTs) at hire and at intervals during employment. We compared sensitization incidence rates (IRs) and prevalence rates for workers hired before the program (legacy workers) with rates for program workers, including program worker subgroups. We also examined trends in BeLPTs from a single laboratory. RESULTS In all, five of 43 legacy workers (IR = 3.8/1,000 person-months) and three of 82 program workers (IR = 1.9/1,000 person-months) were beryllium sensitized, for an incidence rate ratio (IRR) of 2.0 (95% confidence interval [CI] 0.5, 10.1). Two of 37 pre-enclosure program workers (IR = 2.4/1,000 person-months) and one of 45 post-enclosure program workers (IR = 1.4/1,000 person-months) were beryllium sensitized, for IRRs of 1.6 (95% CI 0.3, 11.9) and 2.8 (95% CI 0.4, 66.2), respectively, compared with legacy workers. Test for trend in prevalence rates was significant. Among 2,159 first-draw BeLPTs during 95 months, we identified seven months when high numbers of redraws were required, with one possible misclassification in this facility. CONCLUSIONS Fewer workers became sensitized after implementation of the preventive program. However, low statistical power due to the facility's small workforce prevents a definitive conclusion about the program's efficacy. These findings have implications for other copper-beryllium facilities, where program components may merit application. JF - Public health reports (Washington, D.C. : 1974) AU - Thomas, Carrie A AU - Bailey, Rachel L AU - Kent, Michael S AU - Deubner, David C AU - Kreiss, Kathleen AU - Schuler, Christine R AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Field Studies Branch, 1095 Willowdale Rd., MS-2800, Morgantown, WV 26505, USA. Carrie.Thomas@cdc.hhs.gov PY - 2009 SP - 112 EP - 124 VL - 124 Suppl 1 SN - 0033-3549, 0033-3549 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Copper KW - 789U1901C5 KW - Beryllium KW - OW5102UV6N KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Equipment Safety KW - Copper -- chemistry KW - Protective Clothing KW - Risk Factors KW - Adult KW - Monitoring, Physiologic -- methods KW - Middle Aged KW - Program Evaluation KW - Female KW - Male KW - Protective Devices KW - Occupational Exposure -- prevention & control KW - Berylliosis -- etiology KW - Safety Management -- methods KW - Air Pollutants, Occupational -- poisoning KW - Chemical Industry -- standards KW - Berylliosis -- prevention & control KW - Beryllium -- chemistry KW - Beryllium -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67504792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=Efficacy+of+a+program+to+prevent+beryllium+sensitization+among+new+employees+at+a+copper-beryllium+alloy+processing+facility.&rft.au=Thomas%2C+Carrie+A%3BBailey%2C+Rachel+L%3BKent%2C+Michael+S%3BDeubner%2C+David+C%3BKreiss%2C+Kathleen%3BSchuler%2C+Christine+R&rft.aulast=Thomas&rft.aufirst=Carrie&rft.date=2009-07-01&rft.volume=124+Suppl+1&rft.issue=&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-27 N1 - Date created - 2009-07-21 N1 - Date revised - 2017-02-15 N1 - SuppNotes - Cited By: Ind Health. 1997 Jul;35(3):374-9 [9248221] Am J Ind Med. 2004 Nov;46(5):453-62 [15490468] J Occup Environ Med. 1999 Apr;41(4):304-8 [10224597] Am Rev Respir Dis. 1964 Jan;89:100-2 [14114403] Arch Environ Health. 1964 Oct;9:473-7 [14185553] Am J Ind Med. 2005 Mar;47(3):195-205 [15712254] J Occup Environ Med. 2006 Feb;48(2):204-11 [16474270] Inhal Toxicol. 2006 Oct;18(11):901-10 [16864408] J Occup Environ Hyg. 2007 Mar;4(3):D23-30 [17237019] Occup Environ Med. 2007 Feb;64(2):134-40 [17043076] Annu Rev Public Health. 2007;28:259-77 [17094767] J Occup Med. 1969 Sep;11(9):480-5 [5350221] Toxicology. 1996 Jul 17;111(1-3):213-24 [8711738] Am J Ind Med. 1996 Jul;30(1):16-25 [8837677] Chest. 2001 Feb;119(2):647-50 [11171753] J Occup Environ Med. 2001 Mar;43(3):231-7 [11285871] Appl Occup Environ Hyg. 2001 Mar;16(3):405-17 [11297055] Int Arch Occup Environ Health. 2001 Apr;74(3):167-76 [11355290] Appl Occup Environ Hyg. 2001 May;16(5):559-67 [11370935] Appl Occup Environ Hyg. 2001 May;16(5):579-92 [11370937] Toxicology. 2003 Feb 1;183(1-3):39-56 [12504341] Environ Health Perspect. 2003 Jul;111(9):1202-8 [12842774] Am J Ind Med. 2004 Sep;46(3):207-18 [15307119] J Occup Environ Med. 2004 Sep;46(9):953-61 [15354061] Occup Environ Med. 1997 Aug;54(8):605-12 [9326165] N1 - Last updated - 2017-02-15 ER - TY - JOUR T1 - Interpretation and considerations on the safety evaluation of human drug metabolites. AN - 67501294; 19563206 AB - The final Food and Drug Administration guidance on the safety testing of drug metabolites was published in February 2008. Discussions of the role and applications of this guidance were addressed at several public scientific meetings over the past year. One of the main differences between the draft and the finalized guidance is that in the latter, the human metabolite level was correlated to the parent drug level in plasma, whereas this parameter was considered in relationship to administered dose or total exposure in the draft guidance. The parent drug concentration in plasma has traditionally been the parameter commonly measured in animals during drug development and the one used to estimate drug clinical levels and to assess human risk. Moreover, circulating parent drug in general is the molecule with the intended therapeutic and pharmacologic effect. Therefore, it is appropriate to compare metabolite concentration to that of the parent drug. This report elaborates on this issue and supports other alternative rational and scientific approaches on the design of nonclinical studies that may be needed to test a human drug metabolite. JF - Chemical research in toxicology AU - Atrakchi, Aisar H AD - Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. aisar.atrakchi@fda.hhs.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1217 EP - 1220 VL - 22 IS - 7 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Guidelines as Topic KW - Drug Evaluation, Preclinical KW - Pharmacokinetics KW - Pharmaceutical Preparations -- metabolism KW - Pharmaceutical Preparations -- blood KW - Toxicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67501294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Interpretation+and+considerations+on+the+safety+evaluation+of+human+drug+metabolites.&rft.au=Atrakchi%2C+Aisar+H&rft.aulast=Atrakchi&rft.aufirst=Aisar&rft.date=2009-07-01&rft.volume=22&rft.issue=7&rft.spage=1217&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx900124j LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-13 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx900124j ER - TY - JOUR T1 - Appetite suppressants, cardiac valve disease and combination pharmacotherapy. AN - 67494287; 19092640 AB - The prevalence of obesity in the United States is a major health problem associated with significant morbidity, mortality, and economic burden. Although obesity and drug addiction are typically considered distinct clinical entities, both diseases involve dysregulation of biogenic amine neuron systems in the brain. Thus, research efforts to develop medications for treating drug addiction can contribute insights into the pharmacotherapy for obesity. Here, we review the neurochemical mechanisms of selected stimulant medications used in the treatment of obesity and issues related to fenfluramine-associated cardiac valvulopathy. In particular, we discuss the evidence that cardiac valve disease involves activation of mitogenic serotonin 2B (5-HT2B) receptors by norfenfluramine, the major metabolite of fenfluramine. Advances in medication discovery suggest that novel molecular entities that target 2 different neurochemical mechanisms, that is, "combination pharmacotherapy," will yield efficacious antiobesity medications with reduced adverse side effects. JF - American journal of therapeutics AU - Rothman, Richard B AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institutes of Health, National Institute on Drug Abuse, Department of Health and Human Services, Baltimore, MD 21224, USA. rrothman@mail.nih.gov PY - 2009 SP - 354 EP - 364 VL - 16 IS - 4 KW - Appetite Depressants KW - 0 KW - Receptor, Serotonin, 5-HT2B KW - Serotonin 5-HT2 Receptor Agonists KW - Norfenfluramine KW - 1886-26-6 KW - Fenfluramine KW - 2DS058H2CF KW - Phentermine KW - C045TQL4WP KW - Index Medicus KW - Drug Therapy, Combination KW - Norfenfluramine -- metabolism KW - Receptor, Serotonin, 5-HT2B -- metabolism KW - Dose-Response Relationship, Drug KW - Humans KW - Substance-Related Disorders -- drug therapy KW - Substance-Related Disorders -- metabolism KW - Phentermine -- therapeutic use KW - Phentermine -- adverse effects KW - Obesity -- drug therapy KW - Fenfluramine -- adverse effects KW - Obesity -- metabolism KW - Fenfluramine -- metabolism KW - Appetite Depressants -- adverse effects KW - Fenfluramine -- therapeutic use KW - Heart Valve Diseases -- chemically induced KW - Appetite Depressants -- metabolism KW - Appetite Depressants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67494287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+therapeutics&rft.atitle=Appetite+suppressants%2C+cardiac+valve+disease+and+combination+pharmacotherapy.&rft.au=Rothman%2C+Richard+B%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2009-07-01&rft.volume=16&rft.issue=4&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=American+journal+of+therapeutics&rft.issn=1536-3686&rft_id=info:doi/10.1097%2FMJT.0b013e31817fde95 LA - English DB - ProQuest Environmental Science Collection N1 - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MJT.0b013e31817fde95 ER - TY - JOUR T1 - Medication assisted treatment in the treatment of drug abuse and dependence in HIV/AIDS infected drug users. AN - 67488873; 19601770 AB - Drug use and HIV/AIDS are global public health issues. The World Health Organization (WHO) estimates that up to 30% of HIV infections are related to drug use and associated behaviors. The intersection, of the twin epidemics of HIV and drug/alcohol use, results in difficult medical management issues for the health care providers and researchers who work in the expanding global HIV prevention and treatment fields. Access to care and treatment, medication adherence to multiple therapeutic regimens, and concomitant drug -drug interactions of prescribed treatments are difficult barriers for drug users to overcome without directed interventions. Injection drug users are frequently disenfranchised from medical care and suffer sigma and discrimination creating additional barriers to care and treatment for their drug abuse and dependence as well as HIV infection. In an increasing number of studies, medication assisted treatment of drug abuse and dependence has been shown to be an important HIV prevention intervention. Controlling the global transmission of HIV will require further investment in evidence-based interventions and programs to enhance access to care and treatment of individuals who abuse illicit drugs and alcohol. In this review, we present the cumulative evidence of the importance of medication assisted treatment in the prevention, care, and treatment of HIV infected individuals who also abuse drugs and alcohol. JF - Current HIV research AU - Kresina, Thomas F AU - Bruce, R Douglas AU - McCance-Katz, Elinore F AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, 1 Choke Cherry Road, Rockville, Maryland 20857, USA. tkresina@samhsa.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 354 EP - 364 VL - 7 IS - 4 KW - Index Medicus KW - Drug Users KW - Humans KW - Treatment Outcome KW - Acquired Immunodeficiency Syndrome -- complications KW - Substance-Related Disorders -- drug therapy KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67488873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+HIV+research&rft.atitle=Medication+assisted+treatment+in+the+treatment+of+drug+abuse+and+dependence+in+HIV%2FAIDS+infected+drug+users.&rft.au=Kresina%2C+Thomas+F%3BBruce%2C+R+Douglas%3BMcCance-Katz%2C+Elinore+F&rft.aulast=Kresina&rft.aufirst=Thomas&rft.date=2009-07-01&rft.volume=7&rft.issue=4&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Current+HIV+research&rft.issn=1873-4251&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-08 N1 - Date created - 2009-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of COSHH essentials: methylene chloride, isopropanol, and acetone exposures in a small printing plant. AN - 67449902; 19435980 AB - The current study evaluated the Control of Substances Hazardous to Health (COSHH) Essentials model for short-term task-based exposures and full-shift exposures using measured concentrations of three volatile organic chemicals at a small printing plant. A total of 188 exposure measurements of isopropanol and 187 measurements of acetone were collected and each measurement took approximately 60 min. Historically, collected time-weighted average concentrations (seven results) were evaluated for methylene chloride. The COSHH Essentials model recommended general ventilation control for both isopropanol and acetone. There was good agreement between the task-based exposure measurements and the COSHH Essentials predicted exposure range (PER) for cleaning and print preparation with isopropanol and for cleaning with acetone. For the other tasks and for full-shift exposures, agreement between the exposure measurements and the PER was either moderate or poor. However, for both isopropanol and acetone, our findings suggested that the COSHH Essentials model worked reasonably well because the probabilities of short-term exposure measurements exceeding short-term occupational exposure limits (OELs) or full-shift exposures exceeding the corresponding full-shift OELs were <0.05 under the recommended control strategy. For methylene chloride, the COSHH Essentials recommended containment control but a follow-up study was not able to be performed because it had already been replaced with a less hazardous substance (acetone). This was considered a more acceptable alternative to increasing the level of control. JF - The Annals of occupational hygiene AU - Lee, Eun Gyung AU - Harper, Martin AU - Bowen, Russell B AU - Slaven, James AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 463 EP - 474 VL - 53 IS - 5 KW - Air Pollutants, Occupational KW - 0 KW - Hazardous Substances KW - Acetone KW - 1364PS73AF KW - Methylene Chloride KW - 588X2YUY0A KW - 2-Propanol KW - ND2M416302 KW - Index Medicus KW - Methylene Chloride -- analysis KW - Humans KW - Acetone -- analysis KW - Risk Assessment -- methods KW - Environmental Monitoring -- methods KW - 2-Propanol -- analysis KW - Occupational Exposure -- prevention & control KW - Printing KW - Air Pollutants, Occupational -- analysis KW - Hazardous Substances -- analysis KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67449902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Evaluation+of+COSHH+essentials%3A+methylene+chloride%2C+isopropanol%2C+and+acetone+exposures+in+a+small+printing+plant.&rft.au=Lee%2C+Eun+Gyung%3BHarper%2C+Martin%3BBowen%2C+Russell+B%3BSlaven%2C+James&rft.aulast=Lee&rft.aufirst=Eun&rft.date=2009-07-01&rft.volume=53&rft.issue=5&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmep023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-05 N1 - Date created - 2009-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mep023 ER - TY - JOUR T1 - To eat or not to eat? Food safety in the United States. AN - 67430286; 19559125 JF - Journal of the American Dietetic Association AU - Galson, Steven K AD - US Department of Health and Human Services, USA. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1142 VL - 109 IS - 7 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - United States Environmental Protection Agency KW - Humans KW - United States Department of Agriculture KW - Food Contamination -- prevention & control KW - Consumer Product Safety KW - Food Contamination -- analysis KW - Legislation, Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67430286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dietetic+Association&rft.atitle=To+eat+or+not+to+eat%3F+Food+safety+in+the+United+States.&rft.au=Galson%2C+Steven+K&rft.aulast=Galson&rft.aufirst=Steven&rft.date=2009-07-01&rft.volume=109&rft.issue=7&rft.spage=1142&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dietetic+Association&rft.issn=1878-3570&rft_id=info:doi/10.1016%2Fj.jada.2009.05.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-09 N1 - Date created - 2009-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jada.2009.05.020 ER - TY - JOUR T1 - Characterization of exposures among cemented tungsten carbide workers. Part I: Size-fractionated exposures to airborne cobalt and tungsten particles. AN - 67397451; 18628793 AB - As many as 30,000 workers in the United States of America are exposed to cemented tungsten carbides (CTC), alloys composed primarily of tungsten carbide and cobalt, which are used in cutting tools. Inhalation of cobalt-containing particles may be sufficient for the development of occupational asthma, whereas tungsten carbide particles in association with cobalt particles are associated with the development of hard metal disease (HMD) and lung cancer. Historical epidemiology and exposure studies of CTC workers often rely only on measures of total airborne cobalt mass concentration. In this study, we characterized cobalt- and tungsten-containing aerosols generated during the production of CTC with emphasis on (1) aerosol "total" mass (n=252 closed-face 37 mm cassette samples) and particle size-selective mass concentrations (n=108 eight-stage cascade impactor samples); (2) particle size distributions; and (3) comparison of exposures obtained using personal cassette and impactor samplers. Total cobalt and tungsten exposures were highest in work areas that handled powders (e.g., powder mixing) and lowest in areas that handled finished product (e.g., grinding). Inhalable, thoracic, and respirable cobalt and tungsten exposures were observed in all work areas, indicating potential for co-exposures to particles capable of getting deposited in the upper airways and alveolar region of the lung. Understanding the risk of CTC-induced adverse health effects may require two exposure regimes: one for asthma and the other for HMD and lung cancer. All sizes of cobalt-containing particles that deposit in the lung and airways have potential to cause asthma, thus a thoracic exposure metric is likely biologically appropriate. Cobalt-tungsten mixtures that deposit in the alveolar region of the lung may potentially cause HMD and lung cancer, thus a respirable exposure metric for both metals is likely biologically appropriate. By characterizing size-selective and co-exposures as well as multiple exposure pathways, this series of papers offer an approach for developing biologically meaningful exposure metrics for use in epidemiology. JF - Journal of exposure science & environmental epidemiology AU - Stefaniak, Aleksandr B AU - Virji, M Abbas AU - Day, Gregory A AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. astefaniak@cdc.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 475 EP - 491 VL - 19 IS - 5 KW - Tungsten Compounds KW - 0 KW - tungsten carbide KW - 11130-73-7 KW - Cobalt KW - 3G0H8C9362 KW - Index Medicus KW - Particle Size KW - Humans KW - Quality Control KW - Occupational Exposure KW - Cobalt -- toxicity KW - Tungsten Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67397451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Characterization+of+exposures+among+cemented+tungsten+carbide+workers.+Part+I%3A+Size-fractionated+exposures+to+airborne+cobalt+and+tungsten+particles.&rft.au=Stefaniak%2C+Aleksandr+B%3BVirji%2C+M+Abbas%3BDay%2C+Gregory+A&rft.aulast=Stefaniak&rft.aufirst=Aleksandr&rft.date=2009-07-01&rft.volume=19&rft.issue=5&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=1559-064X&rft_id=info:doi/10.1038%2Fjes.2008.37 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-01 N1 - Date created - 2009-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/jes.2008.37 ER - TY - JOUR T1 - Single amino acid changes in the mumps virus haemagglutinin-neuraminidase and polymerase proteins are associated with neuroattenuation. AN - 67395620; 19282431 AB - It has previously been shown that three amino acid changes, one each in the fusion (F; Ala/Thr-91-->Thr), haemagglutinin-neuraminidase (HN; Ser-466-->Asn) and polymerase (L; Ile-736-->Val) proteins, are associated with attenuation of a neurovirulent clinical isolate of mumps virus (88-1961) following serial passage in vitro. Here, using full-length cDNA plasmid clones and site-directed mutagenesis, it was shown that the single amino acid change in the HN protein and to a lesser extent, the change in the L protein, resulted in neuroattenuation, as assessed in rats. The combination of both amino acid changes caused neuroattenuation of the virus to levels previously reported for the clinical isolate following attenuation in vitro. The amino acid change in the F protein, despite having a dramatic effect on protein function in vitro, was previously shown to not be involved in the observed neuroattenuation, highlighting the importance of conducting confirmatory in vivo studies. This report provides additional supporting evidence for the role of the HN protein as a virulence factor and, as far as is known, is the first report to associate an amino acid change in the L protein with mumps virus neuroattenuation. JF - The Journal of general virology AU - Malik, Tahir H AU - Wolbert, Candie AU - Nerret, Laura AU - Sauder, Christian AU - Rubin, Steven AD - DVP/Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. tahir.malik@fda.hhs.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1741 EP - 1747 VL - 90 SN - 0022-1317, 0022-1317 KW - Gene Products, pol KW - 0 KW - HN Protein KW - Virulence Factors KW - Index Medicus KW - Virulence KW - Severity of Illness Index KW - Rats KW - Mutagenesis, Site-Directed KW - Animals KW - Brain -- pathology KW - Hydrocephalus -- pathology KW - Brain -- virology KW - Mutation, Missense KW - Mumps virus -- genetics KW - HN Protein -- genetics KW - Gene Products, pol -- physiology KW - HN Protein -- physiology KW - Amino Acid Substitution -- genetics KW - Virulence Factors -- physiology KW - Virulence Factors -- genetics KW - Mumps virus -- pathogenicity KW - Gene Products, pol -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67395620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+general+virology&rft.atitle=Single+amino+acid+changes+in+the+mumps+virus+haemagglutinin-neuraminidase+and+polymerase+proteins+are+associated+with+neuroattenuation.&rft.au=Malik%2C+Tahir+H%3BWolbert%2C+Candie%3BNerret%2C+Laura%3BSauder%2C+Christian%3BRubin%2C+Steven&rft.aulast=Malik&rft.aufirst=Tahir&rft.date=2009-07-01&rft.volume=90&rft.issue=&rft.spage=1741&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+general+virology&rft.issn=00221317&rft_id=info:doi/10.1099%2Fvir.0.009449-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-30 N1 - Date created - 2009-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1099/vir.0.009449-0 ER - TY - JOUR T1 - Using indoor air quality monitoring in 6 counties to change policy in North Carolina. AN - 67385632; 19527589 AB - Indoor air quality monitoring has become a valuable tool for states wanting to assess levels of particulate matter before and after smoke-free policies are implemented. However, many states face barriers in passing comprehensive smoke-free legislation, making such study comparisons unlikely. We used indoor air monitoring data to educate decision makers about the value of comprehensive smoke-free laws in a state with strong historical ties to tobacco. We trained teams in 6 counties in North Carolina to monitor air quality in hospitality venues with 1 of 3 possible smoking policy designations: 1) smoke-free, 2) separate smoking and nonsmoking sections (mixed), or 3) smoking allowed in all areas. Teams monitored 152 venues for respirable suspended particles that were less than 2.5 microm in diameter and collected information on venue characteristics. The data were combined and analyzed by venue policy and by county. Our findings were presented to key decision makers, and we then collected information on media publicity about these analyses. Overall, smoke-free venues had the lowest particulate matter levels (15 microg/m3), well below established Environmental Protection Agency standards. Venues with mixed policies and venues that permitted smoking in all areas had particulate matter levels that are considered unhealthy by Environmental Protection Agency standards. The media coverage of our findings included newspaper, radio, and television reports. Findings were also discussed with local health directors, state legislators, and public health advocates. Study data have been used to quantify particulate matter levels, raise awareness about the dangers of secondhand smoke, build support for evidence-based policies, and promote smoke-free policies among policy makers. The next task is to turn this effort into meaningful policy change that will protect everyone from the harms of secondhand smoke. JF - Preventing chronic disease AU - Proescholdbell, Scott AU - Steiner, Julea AU - Goldstein, Adam O AU - Malek, Sally Herndon AD - Injury Epidemiology and Surveillance Unit, Injury and Violence Prevention Branch, Division of Public Health, North Carolina Department of Health and Human Services, 1915 Mail Service Center, Raleigh, NC 27699-1932, USA. scott.proescholdbell@ncmail.net Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1 VL - 6 IS - 3 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Inhalation Exposure -- prevention & control KW - Humans KW - North Carolina KW - Inhalation Exposure -- legislation & jurisprudence KW - Air Pollution, Indoor -- analysis KW - Tobacco Smoke Pollution -- prevention & control KW - Tobacco Smoke Pollution -- analysis KW - Social Marketing KW - Health Policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67385632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventing+chronic+disease&rft.atitle=Using+indoor+air+quality+monitoring+in+6+counties+to+change+policy+in+North+Carolina.&rft.au=Proescholdbell%2C+Scott%3BSteiner%2C+Julea%3BGoldstein%2C+Adam+O%3BMalek%2C+Sally+Herndon&rft.aulast=Proescholdbell&rft.aufirst=Scott&rft.date=2009-07-01&rft.volume=6&rft.issue=3&rft.spage=A88&rft.isbn=&rft.btitle=&rft.title=Preventing+chronic+disease&rft.issn=1545-1151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-14 N1 - Date created - 2009-06-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Prev Med. 2001 Feb;20(2 Suppl):10-5 [11173214] Am J Public Health. 2007 Nov;97(11):2035-9 [17901438] MMWR Morb Mortal Wkly Rep. 2001 Dec 14;50(49):1101-6 [11794619] MMWR Morb Mortal Wkly Rep. 2002 Apr 12;51(14):300-3 [12002168] J Occup Environ Med. 2004 Apr;46(4):347-56 [15076653] BMJ. 2004 Apr 24;328(7446):977-80 [15066887] BMJ. 2004 Apr 24;328(7446):980-3 [15105323] J Occup Environ Med. 2004 Sep;46(9):887-905 [15354053] JAMA. 1998 Dec 9;280(22):1909-14 [9851475] MMWR Morb Mortal Wkly Rep. 2004 Nov 12;53(44):1038-41 [15538318] Tob Control. 2005 Aug;14(4):236-41 [16046685] N C Med J. 2005 May-Jun;66(3):186-91 [16130941] J Occup Environ Med. 2006 Sep;48(9):906-13 [16966957] Circulation. 2006 Oct 3;114(14):1490-6 [17000911] Circulation. 2006 Oct 3;114(14):1450-1 [17015803] Eur Heart J. 2006 Oct;27(20):2468-72 [16940340] Prev Med. 2007 Jul;45(1):3-8 [17482249] J Occup Environ Med. 2001 Aug;43(8):680-6 [11515250] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effects of topically applied glycolic acid and salicylic acid on ultraviolet radiation-induced erythema, DNA damage and sunburn cell formation in human skin. AN - 67300020; 19411163 AB - alpha-Hydroxy acids (alphaHAs) are reported to reduce signs of aging in the skin and are widely used cosmetic ingredients. Several studies suggest that alphaHA can increase the sensitivity of skin to ultraviolet radiation. More recently, beta-hydroxy acids (betaHAs), or combinations of alphaHA and betaHA have also been incorporated into antiaging skin care products. Concerns have also arisen about increased sensitivity to ultraviolet radiation following use of skin care products containing beta-HA. To determine whether topical treatment with glycolic acid, a representative alphaHA, or with salicylic acid, a betaHA, modifies the short-term effects of solar simulated radiation (SSR) in human skin. Fourteen subjects participated in this study. Three of the four test sites on the mid-back of each subject were treated daily Monday-Friday, for a total of 3.5 weeks, with glycolic acid (10%), salicylic acid (2%), or vehicle (control). The fourth site received no treatment. After the last treatment, each site was exposed to SSR, and shave biopsies from all four sites were obtained. The endpoints evaluated in this study were erythema (assessed visually and instrumentally), DNA damage and sunburn cell formation. Treatment with glycolic acid resulted in increased sensitivity of human skin to SSR, measured as an increase in erythema, DNA damage and sunburn cell formation. Salicylic acid did not produce significant changes in any of these biomarkers. Short-term topical application of glycolic acid in a cosmetic formulation increased the sensitivity of human skin to SSR, while a comparable treatment with salicylic acid did not. JF - Journal of dermatological science AU - Kornhauser, Andrija AU - Wei, Rong-Rong AU - Yamaguchi, Yuji AU - Coelho, Sergio G AU - Kaidbey, Kays AU - Barton, Curtis AU - Takahashi, Kaoruko AU - Beer, Janusz Z AU - Miller, Sharon A AU - Hearing, Vincent J AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. akornhause@aol.com Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 10 EP - 17 VL - 55 IS - 1 KW - Glycolates KW - 0 KW - Keratolytic Agents KW - Pyrimidine Dimers KW - glycolic acid KW - 0WT12SX38S KW - Salicylic Acid KW - O414PZ4LPZ KW - Index Medicus KW - Pyrimidine Dimers -- metabolism KW - DNA Damage KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Administration, Topical KW - Erythema -- etiology KW - Erythema -- pathology KW - Keratolytic Agents -- administration & dosage KW - Radiation Injuries -- chemically induced KW - Skin -- pathology KW - Glycolates -- administration & dosage KW - Keratolytic Agents -- adverse effects KW - Radiation Injuries -- pathology KW - Sunburn -- pathology KW - Salicylic Acid -- adverse effects KW - Sunburn -- etiology KW - Skin -- radiation effects KW - Skin -- drug effects KW - Glycolates -- adverse effects KW - Salicylic Acid -- administration & dosage KW - Ultraviolet Rays -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67300020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+dermatological+science&rft.atitle=The+effects+of+topically+applied+glycolic+acid+and+salicylic+acid+on+ultraviolet+radiation-induced+erythema%2C+DNA+damage+and+sunburn+cell+formation+in+human+skin.&rft.au=Kornhauser%2C+Andrija%3BWei%2C+Rong-Rong%3BYamaguchi%2C+Yuji%3BCoelho%2C+Sergio+G%3BKaidbey%2C+Kays%3BBarton%2C+Curtis%3BTakahashi%2C+Kaoruko%3BBeer%2C+Janusz+Z%3BMiller%2C+Sharon+A%3BHearing%2C+Vincent+J&rft.aulast=Kornhauser&rft.aufirst=Andrija&rft.date=2009-07-01&rft.volume=55&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+dermatological+science&rft.issn=1873-569X&rft_id=info:doi/10.1016%2Fj.jdermsci.2009.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-21 N1 - Date created - 2009-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Acta Derm Venereol. 1991;71(1):37-40 [1676212] Photodermatol Photoimmunol Photomed. 1990 Aug;7(4):159-65 [2076371] Dermatol Surg. 1996 May;22(5):435-7 [8634805] J Invest Dermatol. 1996 Jun;106(6):1307-13 [8752675] Clin Dermatol. 1996 Mar-Apr;14(2):217-26 [9117988] Contact Dermatitis. 1996 Jul;35(1):1-10 [8896947] Cancer Epidemiol Biomarkers Prev. 1998 Mar;7(3):199-202 [9521432] Mol Med Today. 1999 Feb;5(2):86-94 [10200950] Photochem Photobiol. 1999 May;69(5):571-4 [10333763] J Invest Dermatol. 1961 Nov;37:351-7 [13883406] Int J Biochem Cell Biol. 2005 Aug;37(8):1547-53 [15896663] J Invest Dermatol. 2005 Jun;124(6):1326-32 [15955111] Photochem Photobiol Sci. 2006 Feb;5(2):199-207 [16465306] Photochem Photobiol. 2006 May-Jun;82(3):651-5 [16522135] Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5 [17956979] J Invest Dermatol. 2009 Feb;129(2):468-75 [18704106] Natl Toxicol Program Tech Rep Ser. 2007 Sep;(524):1-242 [21921960] Mutat Res. 2000 May 30;450(1-2):193-9 [10838143] J Am Acad Dermatol. 2000 Aug;43(2 Pt 1):238-43 [10906645] Photochem Photobiol. 2000 Sep;72(3):340-4 [10989604] Dermatol Surg. 2001 May;27(5):429-33 [11359487] Mol Carcinog. 2001 Jul;31(3):152-60 [11479924] J Photochem Photobiol B. 2001 Oct;63(1-3):84-7 [11684455] Eur J Pharmacol. 2002 Jun 28;447(1):1-9 [12106797] Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1645-52 [12496056] Hum Mutat. 2003 Mar;21(3):217-28 [12619107] Photodermatol Photoimmunol Photomed. 2003 Feb;19(1):21-7 [12713551] FASEB J. 2003 Jun;17(9):1177-9 [12692083] Photochem Photobiol Sci. 2002 Jun;1(6):365-77 [12856704] Int J Toxicol. 2003;22 Suppl 3:1-108 [14617432] Arch Dermatol. 1974 Oct;110(4):586-90 [4412623] Dermatologica. 1975;151(5):268-73 [1225664] J Invest Dermatol. 1983 Dec;81(6):524-7 [6644094] Photochem Photobiol. 1987 Aug;46(2):207-12 [3628509] Arch Dermatol. 1988 Jun;124(6):869-71 [3377516] Photochem Photobiol. 1991 Aug;54(2):225-32 [1780359] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jdermsci.2009.03.011 ER - TY - JOUR T1 - Screening biomaterials for stimulation of nitric oxide-mediated inflammation. AN - 67286600; 18481787 AB - Inflammatory reactions to biomaterials may include macrophage-mediated generation of nitric oxide (NO), which may harm patient tissue or potentially interfere with proper function of an implanted device. RAW 264.7 cells were grown in culture and treated at various times with lipopolysaccharide (LPS, endotoxin), murine recombinant gamma-interferon (mrIFN-gamma), and different preparations of hyaluronic acid (HA). Increase in fluorescence of 2,3-diaminonaphthalene (DAN) allowed for detection of initial (24 h or less) NO inflammatory responses of RAW 264.7 to LPS from E. coli O26:B6. By looking at early time points, mrIFN-gamma augmentation of the LPS effect was observed, simulating a complex immune reaction. Activation through nuclear factor-kappaB (NF-kappaB), was confirmed in this system by parthenolide inhibition of LPS stimulation. Stimulation of RAW 264.7 by different HA preparations resulted in NO responses that correlated with the amount of LPS present. In the presence of mrIFN-gamma, a significant inflammatory reaction to HA was observed when the concentration of contaminating LPS was as low as 0.15 EU/mL. NO production in the presence of mrIFN-gamma by RAW 264.7 may serve as a convenient in vitro system to routinely screen biomaterials for potentially harmful macrophage-mediated inflammation whereby the safety of implanted medical devices might be compromised. JF - Journal of biomedical materials research. Part A AU - Lyle, Daniel B AU - Shallcross, Jonathan C AU - Durfor, Charles N AU - Hitchins, Victoria M AU - Breger, Joyce C AU - Langone, John J AD - Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, FDA,10903 New Hampshire Ave, Silver Spring, Maryland 20993-0002, USA. dan.lyle@fda.hhs.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 82 EP - 93 VL - 90 IS - 1 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Biocompatible Materials KW - Lipopolysaccharides KW - Nitrites KW - Sesquiterpenes KW - 2,3-diaminonaphthalene KW - 2BNZ6BRS87 KW - parthenolide KW - 2RDB26I5ZB KW - Nitric Oxide KW - 31C4KY9ESH KW - Interferon-gamma KW - 82115-62-6 KW - Hyaluronic Acid KW - 9004-61-9 KW - 2-Naphthylamine KW - CKR7XL41N4 KW - Index Medicus KW - Macrophages -- cytology KW - Animals KW - Macrophages -- immunology KW - Nitrites -- metabolism KW - Humans KW - Lipopolysaccharides -- pharmacology KW - Interferon-gamma -- pharmacology KW - Mice KW - Interferon-gamma -- immunology KW - Macrophages -- drug effects KW - 2-Naphthylamine -- analogs & derivatives KW - Hyaluronic Acid -- pharmacology KW - 2-Naphthylamine -- pharmacology KW - Lipopolysaccharides -- immunology KW - Sesquiterpenes -- pharmacology KW - Materials Testing KW - Cell Line KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Biocompatible Materials -- adverse effects KW - Biocompatible Materials -- pharmacology KW - Nitric Oxide -- immunology KW - Inflammation -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67286600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomedical+materials+research.+Part+A&rft.atitle=Screening+biomaterials+for+stimulation+of+nitric+oxide-mediated+inflammation.&rft.au=Lyle%2C+Daniel+B%3BShallcross%2C+Jonathan+C%3BDurfor%2C+Charles+N%3BHitchins%2C+Victoria+M%3BBreger%2C+Joyce+C%3BLangone%2C+John+J&rft.aulast=Lyle&rft.aufirst=Daniel&rft.date=2009-07-01&rft.volume=90&rft.issue=1&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomedical+materials+research.+Part+A&rft.issn=1552-4965&rft_id=info:doi/10.1002%2Fjbm.a.32060 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-31 N1 - Date created - 2009-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jbm.a.32060 ER - TY - JOUR T1 - Laboratory evaluation of a field-portable sealed source X-ray fluorescence spectrometer for determination of metals in air filter samples. AN - 67164963; 19387888 AB - Recent advances in field-portable X-ray fluorescence (FP XRF) spectrometer technology have made it a potentially valuable screening tool for the industrial hygienist to estimate worker exposures to airborne metals. Although recent studies have shown that FP XRF technology may be better suited for qualitative or semiquantitative analysis of airborne lead in the workplace, these studies have not extensively addressed its ability to measure other elements. This study involved a laboratory-based evaluation of a representative model FP XRF spectrometer to measure elements commonly encountered in workplace settings that may be collected on air sample filter media, including chromium, copper, iron, manganese, nickel, lead, and zinc. The evaluation included assessments of (1) response intensity with respect to location on the probe window, (2) limits of detection for five different filter media, (3) limits of detection as a function of analysis time, and (4) bias, precision, and accuracy estimates. Teflon, polyvinyl chloride, polypropylene, and mixed cellulose ester filter media all had similarly low limits of detection for the set of elements examined. Limits of detection, bias, and precision generally improved with increasing analysis time. Bias, precision, and accuracy estimates generally improved with increasing element concentration. Accuracy estimates met the National Institute for Occupational Safety and Health criterion for nearly all the element and concentration combinations. Based on these results, FP XRF spectrometry shows potential to be useful in the assessment of worker inhalation exposures to other metals in addition to lead. JF - Journal of occupational and environmental hygiene AU - Lawryk, Nicholas J AU - Feng, H Amy AU - Chen, Bean T AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-1725, USA. NLawryk@cdc.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 433 EP - 445 VL - 6 IS - 7 KW - Metals, Heavy KW - 0 KW - Index Medicus KW - Inhalation Exposure -- analysis KW - Reference Standards KW - Time Factors KW - Occupational Exposure -- analysis KW - Spectrometry, X-Ray Emission -- instrumentation KW - Filtration KW - Spectrometry, X-Ray Emission -- standards KW - Environmental Monitoring -- standards KW - Metals, Heavy -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67164963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Laboratory+evaluation+of+a+field-portable+sealed+source+X-ray+fluorescence+spectrometer+for+determination+of+metals+in+air+filter+samples.&rft.au=Lawryk%2C+Nicholas+J%3BFeng%2C+H+Amy%3BChen%2C+Bean+T&rft.aulast=Lawryk&rft.aufirst=Nicholas&rft.date=2009-07-01&rft.volume=6&rft.issue=7&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620902932119 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-13 N1 - Date created - 2009-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620902932119 ER - TY - JOUR T1 - Summary of retrospective asbestos and welding fume exposure estimates for a nuclear naval shipyard and their correlation with radiation exposure estimates. AN - 67136507; 19378213 AB - In support of a nested case-control study at a U.S. naval shipyard, the results of the reconstruction of historical exposures were summarized, and an analysis was undertaken to determine the impact of historical exposures to potential chemical confounders. The nested case-control study (N = 4388) primarily assessed the relationship between lung cancer and external ionizing radiation. Chemical confounders considered important were asbestos and welding fume (as iron oxide fume), and the chromium and nickel content of welding fume. Exposures to the potential confounders were estimated by an expert panel based on a set of quantitatively defined categories of exposure. Distributions of the estimated exposures and trends in exposures over time were examined for the study population. Scatter plots and Spearman rank correlation coefficients were used to assess the degree of association between the estimates of exposure to asbestos, welding fume, and ionizing radiation. Correlation coefficients were calculated separately for 0-, 15-, 20-, and 25-year time-lagged cumulative exposures, total radiation dose (which included medical X-ray dose) and occupational radiation dose. Exposed workers' estimated cumulative exposures to asbestos ranged from 0.01 fiber-days/cm(3) to just under 20,000 fiber-days/cm(3), with a median of 29.0 fiber-days/cm(3). Estimated cumulative exposures to welding fume ranged from 0.16 mg-days/m(3) to just over 30,000 mg-days/m(3), with a median of 603 mg-days/m(3). Spearman correlation coefficients between cumulative radiation dose and cumulative asbestos exposures ranged from 0.09 (occupational dose) to 0.47 (total radiation dose), and those between radiation and welding fume from 0.14 to 0.47. The estimates of relative risk for ionizing radiation and lung cancer were unchanged when lowest and highest estimates of asbestos and welding fume were considered. These results suggest a fairly large proportion of study population workers were exposed to asbestos and welding fume, that the absolute level of confounding exposure did not affect the risk estimates, and that weak relationships existed between monitored lifetime cumulative occupational radiation dose and asbestos or welding fume. JF - Journal of occupational and environmental hygiene AU - Zaebst, D D AU - Seel, E A AU - Yiin, J H AU - Nowlin, S J AU - Chen, P AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. ddz1@cdc.gov Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 404 EP - 414 VL - 6 IS - 7 KW - Environmental Pollutants KW - 0 KW - Chromium KW - 0R0008Q3JB KW - Asbestos KW - 1332-21-4 KW - Nickel KW - 7OV03QG267 KW - Index Medicus KW - Lung Neoplasms -- etiology KW - History, 20th Century KW - Chromium -- analysis KW - Nickel -- analysis KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Case-Control Studies KW - Risk Assessment KW - Ships KW - Asbestos -- analysis KW - Occupational Exposure -- history KW - Welding KW - Environmental Pollutants -- analysis KW - Radiation Monitoring KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67136507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Summary+of+retrospective+asbestos+and+welding+fume+exposure+estimates+for+a+nuclear+naval+shipyard+and+their+correlation+with+radiation+exposure+estimates.&rft.au=Zaebst%2C+D+D%3BSeel%2C+E+A%3BYiin%2C+J+H%3BNowlin%2C+S+J%3BChen%2C+P&rft.aulast=Zaebst&rft.aufirst=D&rft.date=2009-07-01&rft.volume=6&rft.issue=7&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620902922573 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-07 N1 - Date created - 2009-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620902922573 ER - TY - RPRT T1 - Multiple Pathways Connecting to School and Work. Vulnerable Youth and the Transition to Adulthood. ASPE Research Brief AN - 61797687; ED508240 AB - Researchers are increasingly recognizing the transition to adulthood as an important developmental stage between adolescence and adulthood (Arnett 2004). Many important processes occur during this period in a young adult's life, including leaving home and forming a family. One crucial activity during the transition to adulthood is successful connection to the labor market. However, there is no "typical" youth connection to the labor market; there are multiple pathways, each characterized by specific causes, consequences, and policy implications. This brief explores the multiple pathways of connection to the labor market for youth transitioning to adulthood. Using data from the National Longitudinal Survey of Youth 1997 (NLSY97), the authors find that while a majority of youth successfully connect to the labor market, many distinct subgroups follow very different, and often less successful, schooling and employment pathways. They identify four distinct categories of youth transitions. Youth either consistently-connect, later-connect, initially-connect, or never-connect to work or school between ages 18 and 24. This brief describes the characteristics of each group and possible determinants of group membership. The findings suggest that targeted programs to help youth connect may be important. The brief concludes with a discussion of the multiple pathways of connection to the labor market during the transition to adulthood. (Contains 5 figures, 2 tables, and 8 footnotes.) AU - Kuehn, Daniel AU - Pergamit, Michael AU - Macomber, Jennifer AU - Vericker, Tracy Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 13 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - National Longitudinal Survey of Youth KW - ERIC, Resources in Education (RIE) KW - Individual Development KW - Risk KW - High School Graduates KW - Postsecondary Education KW - Enrollment KW - Employment Patterns KW - Labor Market KW - Young Adults KW - Longitudinal Studies KW - Adolescents KW - Antisocial Behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61797687?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Young Men and Young Women. Vulnerable Youth and the Transition to Adulthood. ASPE Research Brief AN - 61797439; ED508242 AB - This fact sheet considers differences in behaviors and outcomes between young men and young women as they transition to adulthood. It also considers whether differences between young men and young women are related to the fact that some women are caring for children. Using the National Longitudinal Survey of Youth 1997, the analysis compares adolescent risk behaviors and young adult outcomes for young men and women. Youth of all races and income levels are included and the analysis does not differentiate among them. All differences discussed in this paper are significantly different at the 95 percent confidence level or above. (Contains 1 figure, 4 footnotes, and 1 table.) AU - Zielewski, Erica H. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 4 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - National Longitudinal Survey of Youth KW - ERIC, Resources in Education (RIE) KW - Early Parenthood KW - Crime KW - Gender Differences KW - Young Adults KW - Employment KW - Educational Attainment KW - Longitudinal Studies KW - Antisocial Behavior KW - Income KW - Individual Development KW - Comparative Analysis KW - Risk KW - Enrollment KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61797439?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Youth from Low-Income Families. Vulnerable Youth and the Transition to Adulthood. ASPE Research Brief AN - 61797126; ED508239 AB - In 2007, nearly 40 percent of children in the United States lived in low-income families--families with incomes at or below 200 percent of the federal poverty level (FPL). Youth from low-income families are vulnerable to poor outcomes as adults, as these youth often lack the resources and opportunities found to lead to better outcomes. This fact sheet compares the young adult outcomes and adolescent risk-taking behaviors of youth from low-income families to those from middle-income (201-400 percent of FPL) and high-income (401 percent of FPL or higher) families. All differences discussed in this paper are significant at the 95 percent confidence level or above. (Contains 1 figure, 4 footnotes, and 1 table.) AU - Kent, Adam Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 4 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - National Longitudinal Survey of Youth KW - ERIC, Resources in Education (RIE) KW - Low Income Groups KW - Early Parenthood KW - Crime KW - Young Adults KW - Employment KW - Educational Attainment KW - Longitudinal Studies KW - Antisocial Behavior KW - Income KW - Sexuality KW - Individual Development KW - Comparative Analysis KW - Risk KW - Poverty KW - Disadvantaged Youth KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61797126?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Youth from Distressed Neighborhoods. Vulnerable Youth and the Transition to Adulthood. ASPE Research Brief AN - 61796725; ED508238 AB - The transition to adulthood can be particularly challenging for youth growing up in distressed neighborhoods. Using the National Longitudinal Survey of Youth 1997, this fact sheet compares the adolescent risk behaviors and young adult outcomes of youth from distressed neighborhoods with those of youth from non-distressed neighborhoods. All differences discussed in this paper are significant at the 95 percent confidence level or above. (Contains 1 figure, 1 table and 6 footnotes.) AU - Johnson, Heidi Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 4 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - National Longitudinal Survey of Youth KW - ERIC, Resources in Education (RIE) KW - Low Income Groups KW - Early Parenthood KW - Neighborhoods KW - Young Adults KW - Employment KW - Educational Attainment KW - Longitudinal Studies KW - Antisocial Behavior KW - Income KW - Sexuality KW - Comparative Analysis KW - Risk KW - Disadvantaged Environment KW - Disadvantaged Youth KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61796725?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Second-Generation Latinos Connecting to School and Work. Vulnerable Youth and the Transition to Adulthood. ASPE Research Brief AN - 61796600; ED508241 AB - Immigrants are a large and growing segment of the United States population. In the past 25 years, the United States has witnessed a 150 percent increase in the foreign-born population, with over 35 million foreign-born people living in the United States in 2005 (Vericker, Kuehn, and Capps 2007). Latino immigrants make up the majority of this growth; 53 percent of the foreign-born emigrated from Latin America (Larson 2004). As a result of this increase in the foreign-born population, the share of all US-born children with at least one immigrant parent has more than tripled. Currently, about one-fifth of all children are growing up in immigrant families. The rapid expansion of this population has led many to question how well youth with immigrant parents fare in early adulthood. As second-generation Latino youth continue to make up a larger share of this population, their educational and labor market successes and failures will play a large role in shaping this country's economic future. Using the National Longitudinal Survey of Youth, 1997 cohort, this brief examines young adult connections to school and employment (or connectedness) between the ages of 18 and 24 for children of Latino immigrants (second generation) compared with children of native-born Latinos (third generation), children of native-born non-Hispanic blacks (blacks), and children of native-born non-Hispanic whites and other race groups (whites). (Contains 3 figures, 1 table, and 5 footnotes.) AU - Vericker, Tracy AU - Pergamit, Michael AU - Macomber, Jennifer AU - Kuehn, Daniel Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 9 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - National Longitudinal Survey of Youth KW - ERIC, Resources in Education (RIE) KW - Parent Background KW - Immigrants KW - African Americans KW - Young Adults KW - Employment KW - Educational Attainment KW - Longitudinal Studies KW - Income KW - Whites KW - Comparative Analysis KW - Hispanic Americans KW - Enrollment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61796600?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Youth with Depression/Anxiety. Vulnerable Youth and the Transition to Adulthood. ASPE Research Brief AN - 61796424; ED508243 AB - The transition to adulthood can be particularly challenging when a young adult experiences mental health problems. This fact sheet uses data from the National Longitudinal Survey of Youth 1997 to explore the young adult outcomes and adolescent risk behaviors of youth suffering from depression and anxiety as they make this transition. Depression and anxiety are captured using the MHI-5 scale, a validated measure collected from the youth when they were ages 18 or 19. The researchers designate the 8 percent of youth at the bottom of the scale distribution as experiencing depression/anxiety and compare them to all other youth, which they refer to as youth with less or no depression/anxiety. All differences discussed in this paper are significantly different at the 95 percent confidence level or above. (Contains 1 figure, 1 table and 7 footnotes.) AU - Macomber, Jennifer Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 5 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - National Longitudinal Survey of Youth KW - ERIC, Resources in Education (RIE) KW - Crime KW - Anxiety KW - Depression (Psychology) KW - Mental Health KW - Young Adults KW - Employment KW - Educational Attainment KW - Longitudinal Studies KW - Antisocial Behavior KW - Income KW - Individual Development KW - Comparative Analysis KW - Risk KW - Health Insurance KW - Disadvantaged Youth KW - Parents KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61796424?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Stimulus-reinforcement-based decision making and anxiety: impairment in generalized anxiety disorder (GAD) but not in generalized social phobia (GSP) AN - 57301868; 200918428 AB - Generalized social phobia (GSP) involves the fear/avoidance of social situations whereas generalized anxiety disorder (GAD) involves an intrusive worry about everyday life circumstances. It remains unclear whether these, highly co-morbid, conditions represent distinct disorders or alternative presentations of a single underlying pathology. In this study, we examined stimulus-reinforcement-based decision making in GSP and GAD. Twenty unmedicated patients with GSP, 16 unmedicated patients with GAD and 19 age-, IQ- and gender-matched healthy comparison (HC) individuals completed the Differential Reward/Punishment Learning Task (DRPLT). In this task, the subject chooses between two objects associated with different levels of reward or punishment. Thus, response choice indexes not only reward/punishment sensitivity but also sensitivity to reward/punishment level according to between-object reinforcement distance. We found that patients with GAD committed a significantly greater number of errors than both the patients with GSP and the HC individuals. By contrast, the patients with GSP and the HC individuals did not differ in performance on this task. These results link GAD with anomalous non-affective-based decision making. They also indicate that GSP and GAD are associated with distinct pathophysiologies. Adapted from the source document. JF - Psychological Medicine AU - DeVido, J AU - Jones, M AU - Geraci, M AU - Hollon, N AU - Blair, R J R AU - Pine, D S AU - Blair, K AD - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 1153 EP - 1161 PB - Cambridge University Press, UK VL - 39 IS - 7 SN - 0033-2917, 0033-2917 KW - Sensitivity KW - Decision making KW - Generalized anxiety disorders KW - Punishment KW - Social phobia KW - Rewards KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57301868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Stimulus-reinforcement-based+decision+making+and+anxiety%3A+impairment+in+generalized+anxiety+disorder+%28GAD%29+but+not+in+generalized+social+phobia+%28GSP%29&rft.au=DeVido%2C+J%3BJones%2C+M%3BGeraci%2C+M%3BHollon%2C+N%3BBlair%2C+R+J+R%3BPine%2C+D+S%3BBlair%2C+K&rft.aulast=DeVido&rft.aufirst=J&rft.date=2009-07-01&rft.volume=39&rft.issue=7&rft.spage=1153&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS003329170800487X LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Generalized anxiety disorders; Punishment; Rewards; Decision making; Social phobia; Sensitivity DO - http://dx.doi.org/10.1017/S003329170800487X ER - TY - JOUR T1 - Development of a Murine Mycobacterial Growth Inhibition Assay for Evaluating Vaccines against Mycobacterium tuberculosis , AN - 21501918; 12492649 AB - The development and characterization of new tuberculosis (TB) vaccines has been impeded by the lack of reproducible and reliable in vitro assays for measuring vaccine activity. In this study, we developed a murine in vitro mycobacterial growth inhibition assay for evaluating TB vaccines that directly assesses the capacity of immune splenocytes to control the growth of Mycobacterium tuberculosis within infected macrophages. Using this in vitro assay, protective immune responses induced by immunization with five different types of TB vaccine preparations (Mycobacterium bovis BCG, an attenuated M. tuberculosis mutant strain, a DNA vaccine, a modified vaccinia virus strain Ankara [MVA] construct expressing four TB antigens, and a TB fusion protein formulated in adjuvant) can be detected. Importantly, the levels of vaccine-induced mycobacterial growth-inhibitory responses seen in vitro after 1 week of coculture correlated with the protective immune responses detected in vivo at 28 days postchallenge in a mouse model of pulmonary tuberculosis. In addition, similar patterns of cytokine expression were evoked at day 7 of the in vitro culture by immune splenocytes taken from animals immunized with the different TB vaccines. Among the consistently upregulated cytokines detected in the immune cocultures are gamma interferon, growth differentiation factor 15, interleukin-21 (IL-21), IL-27, and tumor necrosis factor alpha. Overall, we have developed an in vitro functional assay that may be useful for screening and comparing new TB vaccine preparations, investigating vaccine-induced protective mechanisms, and assessing manufacturing issues, including product potency and stability. JF - Clinical and Vaccine Immunology AU - Parra, Marcela AU - Yang, Amy L AU - Lim, JaeHyun AU - Kolibab, Kristopher AU - Derrick, Steven AU - Cadieux, Nathalie AU - Perera, Liyanage P AU - Jacobs, William R AU - Brennan, Michael AU - Morris, Sheldon L AD - Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland, sheldon.morris@fda.hhs.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 1025 EP - 1032 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 16 IS - 7 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Adjuvants KW - Animal models KW - BCG KW - DNA vaccines KW - Differentiation KW - Fusion protein KW - Immune response KW - Immunization KW - Interleukin 21 KW - Interleukin 27 KW - Lung KW - Macrophages KW - Splenocytes KW - Tuberculosis KW - Tumor necrosis factor-a KW - Vaccines KW - g-Interferon KW - Mycobacterium bovis KW - Vaccinia virus KW - Mycobacterium tuberculosis KW - V 22350:Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21501918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Development+of+a+Murine+Mycobacterial+Growth+Inhibition+Assay+for+Evaluating+Vaccines+against+Mycobacterium+tuberculosis+%2C&rft.au=Parra%2C+Marcela%3BYang%2C+Amy+L%3BLim%2C+JaeHyun%3BKolibab%2C+Kristopher%3BDerrick%2C+Steven%3BCadieux%2C+Nathalie%3BPerera%2C+Liyanage+P%3BJacobs%2C+William+R%3BBrennan%2C+Michael%3BMorris%2C+Sheldon+L&rft.aulast=Parra&rft.aufirst=Marcela&rft.date=2009-07-01&rft.volume=16&rft.issue=7&rft.spage=1025&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00067-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Macrophages; g-Interferon; Animal models; Adjuvants; Interleukin 21; Tumor necrosis factor-a; Immunization; Splenocytes; Differentiation; DNA vaccines; BCG; Lung; Interleukin 27; Tuberculosis; Vaccines; Immune response; Fusion protein; Vaccinia virus; Mycobacterium bovis; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/CVI.00067-09 ER - TY - JOUR T1 - Arbovirus Surveillance of Mosquitoes Collected at Sites of Active Rift Valley Fever Virus Transmission: Kenya, 2006-2007 AN - 21074808; 11203501 AB - Mosquitoes collected during an outbreak of Rift Valley fever in Kenya from December 2006 to February 2007 were tested to isolate other mosquito-borne arboviruses circulating in the region. Twenty-seven virus isolations were made comprising seven viruses from three arbovirus families. JF - Journal of Medical Entomology AU - Crabtree, Mary AU - Sang, Rosemary AU - Lutomiah, Joel AU - Richardson, Jason AU - Miller, Barry AD - Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases. Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 3150 Rampart Road, Foothills Campus, Fort Collins, CO 80521. Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 961 EP - 964 PB - Entomological Society of America, 9301 Annapolis Rd. Lanham MD 20706 USA VL - 46 IS - 4 SN - 0022-2585, 0022-2585 KW - Virology & AIDS Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Entomology Abstracts KW - alphavirus KW - bunyavirus KW - flavivirus KW - arbovirus KW - Kenya KW - Viruses KW - Culicidae KW - Rift Valley fever KW - Pest outbreaks KW - Arbovirus KW - Public health KW - Disease transmission KW - Viral diseases KW - Rift Valley fever virus KW - Aquatic insects KW - Rift valleys KW - V 22410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21074808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Entomology&rft.atitle=Arbovirus+Surveillance+of+Mosquitoes+Collected+at+Sites+of+Active+Rift+Valley+Fever+Virus+Transmission%3A+Kenya%2C+2006-2007&rft.au=Crabtree%2C+Mary%3BSang%2C+Rosemary%3BLutomiah%2C+Joel%3BRichardson%2C+Jason%3BMiller%2C+Barry&rft.aulast=Crabtree&rft.aufirst=Mary&rft.date=2009-07-01&rft.volume=46&rft.issue=4&rft.spage=961&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Entomology&rft.issn=00222585&rft_id=info:doi/10.1603%2F033.046.0431 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Viral diseases; Viruses; Rift valleys; Aquatic insects; Disease transmission; Public health; Rift Valley fever; Pest outbreaks; Rift Valley fever virus; Culicidae; Arbovirus; Kenya DO - http://dx.doi.org/10.1603/033.046.0431 ER - TY - JOUR T1 - Dequalinium, a New Inhibitor of Mycobacterium tuberculosis Mycothiol Ligase Identified by High-Throughput Screening AN - 20766136; 10291435 AB - Mycothiol ligase (MshC) is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol that is unique to actinomycetes and whose primary role is to maintain intracellular redox balance and remove toxins. MshC catalyzes the adenosine triphosphate (ATP)a[Euro'dependent condensation of cysteine and glucosamine-inositol (GI) to produce cysteine-glucosamine-inositol (CGI). MshC is essential to Mycobacterium tuberculosis and therefore represents an attractive target for chemotherapeutic intervention. A screening protocol was developed to identify MshC inhibitors based on quantification of residual ATP using a coupled luminescent assay. The protocol was used to screen a library of 3100 compounds in a 384-well plate format (Za[Euro[ampersand]sup2[semicolon] appt[yen 0.65). Fifteen hits (0.48%) were identified from the screen, and 2 hits were confirmed in a secondary assay that measures production of CGI. The structures of both hits contain N-substituted quinolinium moieties, and the more potent of the 2a[Euro'namely, dequalinium chloridea[Euro'inhibits MshC with an IC sub(50) value of 24 A plus or minus 1 A mu M. Further studies showed dequalinium to be an ATP-competitive inhibitor of MshC, to bind MshC with a K sub(D) of 0.22 A mu M, and to inhibit the growth of M. tuberculosis under aerobic and anaerobic conditions with minimum inhibitory and anaerobic bactericidal concentrations of 1.2 and 0.3 A mu g/mL, respectively. The screening protocol described is robust and has enabled the identification of new MshC inhibitors. (Journal of Biomolecular Screening 2009:643-652) JF - Journal of Biomolecular Screening AU - Gutierrez-Lugo, Maria-Teresa AU - Baker, Heather AU - Shiloach, Joseph AU - Boshoff, Helena AU - Bewley, Carole A AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, caroleb@mail.nih.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 643 EP - 652 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 14 IS - 6 SN - 1087-0571, 1087-0571 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - competitive inhibitor KW - luminescent assay KW - mycothiol biosynthesis KW - screening KW - small molecular weight thiol KW - ATP KW - Enzymes KW - Anaerobic conditions KW - Toxins KW - Mycothiol KW - Cysteine KW - Molecular weight KW - Thiols KW - Tuberculosis KW - Condensation KW - high-throughput screening KW - Actinomycetes KW - Mycobacterium tuberculosis KW - W 30915:Pharmaceuticals & Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20766136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Dequalinium%2C+a+New+Inhibitor+of+Mycobacterium+tuberculosis+Mycothiol+Ligase+Identified+by+High-Throughput+Screening&rft.au=Gutierrez-Lugo%2C+Maria-Teresa%3BBaker%2C+Heather%3BShiloach%2C+Joseph%3BBoshoff%2C+Helena%3BBewley%2C+Carole+A&rft.aulast=Gutierrez-Lugo&rft.aufirst=Maria-Teresa&rft.date=2009-07-01&rft.volume=14&rft.issue=6&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057109335743 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cysteine; Molecular weight; Thiols; Enzymes; ATP; high-throughput screening; Condensation; Tuberculosis; Anaerobic conditions; Toxins; Actinomycetes; Mycothiol; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1177/1087057109335743 ER - TY - JOUR T1 - The Yersinia pseudotuberculosis YplA phospholipase differs in its activity, regulation and secretion from that of the Yersinia enterocolitica YplA AN - 20677641; 9450982 AB - Analysis of the Yersinia pseudotuberculosis and Yersinia pestis genomes indicates that both species carry an identical copy of a gene that is predicted to encode a protein which shares 80% similarity to the Yersinia enterocolitica YplA, a secreted phospholipase that has been shown to contribute to virulence. In contrast to well tolerated production of the Y. enterocolitica YplA in Escherichia coli, Y. pseudotuberculosis YplA expression was found to be toxic; however, cell viability could be restored if the Y. pseudotuberculosis YplA was expressed in the presence of its accessory protein YplB. In vitro, Y. pseudotuberculosis YplB was shown to reduce the activity of its cognate phospholipase in a dose-dependent manner. To determine whether the Y. pseudotuberculosis and Y. enterocolitica YplAs were secreted and regulated in a similar manner, secretion and promoter activity assays were performed. Unlike the situation apparent in Y. enterocolitica, expression of the Y. pseudotuberculosis yplA gene did not appear to be controlled by the flagellar regulon, nor did the phospholipase appear to be efficiently exported through the flagellar apparatus. These results indicate that the Yersinia YplAs vary in many of their attributes despite their high degree of amino acid homology. JF - Microbial Pathogenesis AU - Meysick, K C AU - Seidman, J AU - Falconio, J R AD - Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA, karen.meysick@fda.hhs.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 24 EP - 32 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 47 IS - 1 SN - 0882-4010, 0882-4010 KW - Microbiology Abstracts B: Bacteriology KW - Genomes KW - Amino acids KW - Secretion KW - Yersinia pestis KW - Yersinia pseudotuberculosis KW - phospholipase KW - Y chromosome KW - Virulence KW - Promoters KW - Homology KW - Escherichia coli KW - Yersinia enterocolitica KW - Pseudotuberculosis KW - Flagella KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20677641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=The+Yersinia+pseudotuberculosis+YplA+phospholipase+differs+in+its+activity%2C+regulation+and+secretion+from+that+of+the+Yersinia+enterocolitica+YplA&rft.au=Meysick%2C+K+C%3BSeidman%2C+J%3BFalconio%2C+J+R&rft.aulast=Meysick&rft.aufirst=K&rft.date=2009-07-01&rft.volume=47&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2009.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Virulence; Y chromosome; Promoters; Amino acids; Homology; Secretion; phospholipase; Pseudotuberculosis; Flagella; Escherichia coli; Yersinia pseudotuberculosis; Yersinia pestis; Yersinia enterocolitica DO - http://dx.doi.org/10.1016/j.micpath.2009.04.008 ER - TY - JOUR T1 - Effects of foot placement on postural stability of construction workers on stilts AN - 20649416; 9393420 AB - Stilts are elevated tools that are frequently used by construction workers to raise workers 18-40 inches above the ground. The objective of this laboratory study was to evaluate the potential loss of postural stability associated with the use of stilts in various foot placements. Twenty construction workers with at least 1 year of experience in the use of stilts participated in this study. One Kistler[TM] force platform was used to collect kinetic data. Participants were tested under six-foot-placement conditions. These 6 experimental conditions were statically tested under all combinations of 3 levels of elevation: 0" (no stilts), 24" stilt height and 40" stilt height. SAS mixed procedure was used to evaluate the effect of different experimental conditions. The results of the multivariate analysis of variance (MANOVA) and repeated measures of univariate analyses of variance (ANOVAs) demonstrated that stilt height, foot-placement direction, and foot-placement width all had significant effects on the whole-body postural stability. This study found that the higher the stilts were elevated, the greater the postural instability. A stance position with one foot placed forward of the other foot produced greater postural instability than a position with the feet parallel and directly beneath the body. This study found that placement of the feet parallel and directly beneath the body, with the feet positioned a half shoulder width apart, caused a greater amount of postural sway and instability than one and one-and-half shoulder width. This study also found that construction workers using the stilts could perceive the likely postural instability due to the change in foot placements. JF - Applied Ergonomics AU - Pan, Christopher S AU - Chiou, Sharon AU - Kau, Tsui-Ying AU - Bhattacharya, Amit AU - Ammons, Doug AD - Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS-G800, Morgantown, WV 26505, USA, cpan@cdc.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 781 EP - 789 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 40 IS - 4 SN - 0003-6870, 0003-6870 KW - Health & Safety Science Abstracts KW - Stilts KW - Postural instability KW - Foot placements KW - Fall injuries. KW - Kinetics KW - Construction industry KW - Ergonomics KW - Occupational health KW - posture KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20649416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Ergonomics&rft.atitle=Effects+of+foot+placement+on+postural+stability+of+construction+workers+on+stilts&rft.au=Pan%2C+Christopher+S%3BChiou%2C+Sharon%3BKau%2C+Tsui-Ying%3BBhattacharya%2C+Amit%3BAmmons%2C+Doug&rft.aulast=Pan&rft.aufirst=Christopher&rft.date=2009-07-01&rft.volume=40&rft.issue=4&rft.spage=781&rft.isbn=&rft.btitle=&rft.title=Applied+Ergonomics&rft.issn=00036870&rft_id=info:doi/10.1016%2Fj.apergo.2008.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Kinetics; Ergonomics; Construction industry; posture; Occupational health DO - http://dx.doi.org/10.1016/j.apergo.2008.08.003 ER - TY - JOUR T1 - Internal contamination and spoilage of harvested apples by patulin-producing and other toxigenic fungi AN - 20189307; 10186418 AB - A total of 424 apple samples comprised of six varieties (Gala, Red Delicious, Golden Delicious, Fuji, Granny Smith, and Braeburn) were analyzed for internal fungal contamination. Two hundred sixteen apples were incubated intact for 2-4 weeks at room temperature. The cores of the remaining 208 apples were aseptically removed and incubated without supplemental media at room temperature for 3 weeks. After the incubation period was over, the mycological profiles of the analyzed samples were determined. Twelve per cent of the intact apples showed visible growth after 2-4 weeks of incubation at room temperature. Penicillia (including the patulin producer, Penicillium expansum) were the most frequent, found in 8% of the samples followed by Fusarium and Alternaria spp. (each found in 3% of the samples tested). The highest mould incidence was observed in the Red Delicious and Fuji and the lowest in the Granny Smith variety. A variety of microfungi including members of the toxigenic genera Alternaria, Penicillium and Fusarium were isolated from the apple cores. The predominant moulds were Alternaria, Cladosporium, Penicillium and Fusarium spp. recovered from 50, 22, 33 and 23% of the analyzed samples, respectively. Less common were Ulocladium spp., Botrytis cinerea and Aureobasidium pullulans found in less than 4% of the samples. Yeasts were found only in 2% of the samples. Apple cores from all varieties tested showed a high degree of mould contamination. JF - International Journal of Cardiology AU - Tournas, V H AU - Memon, SUppal AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA, valerie.tournas@fda.hhs.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 206 EP - 209 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 135 IS - 2 SN - 0167-5273, 0167-5273 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - A 01360:Plant Diseases KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20189307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cardiology&rft.atitle=Internal+contamination+and+spoilage+of+harvested+apples+by+patulin-producing+and+other+toxigenic+fungi&rft.au=Tournas%2C+V+H%3BMemon%2C+SUppal&rft.aulast=Tournas&rft.aufirst=V&rft.date=2009-07-01&rft.volume=135&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cardiology&rft.issn=01675273&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2009.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2009.05.025 ER - TY - JOUR T1 - Don't Become a Statistic: Work Safely at Heights AN - 20116940; 10263974 AB - In Alabama, a framing crew member who was moving a roof truss into place while supporting himself on an 8-inch wide structural beam fell 27 feet to the ground inside the partially constructed building. The native Mexican laborer, who understood little English, was not wearing or using personal fall protection equipment. An 8-foot by 4-foot truss fell at the same time, s triking the worker's head when he hit the ground. He was pronounced dead at a local hospital. JF - Occupational Health & Safety AU - Mulhern, B AU - Lentz, T J AD - The National Institute for Occupational Safety and Health Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 36 EP - 43 VL - 78 IS - 7 SN - 0362-4064, 0362-4064 KW - Health & Safety Science Abstracts KW - USA, Alabama KW - falls KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20116940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+Health+%26+Safety&rft.atitle=Don%27t+Become+a+Statistic%3A+Work+Safely+at+Heights&rft.au=Mulhern%2C+B%3BLentz%2C+T+J&rft.aulast=Mulhern&rft.aufirst=B&rft.date=2009-07-01&rft.volume=78&rft.issue=7&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Occupational+Health+%26+Safety&rft.issn=03624064&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Alabama; falls; Hospitals ER - TY - JOUR T1 - Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea AN - 20110695; 10241754 AB - We previously reported the development of an in vivo gene mutation assay using the phosphatidylinositol glycan complementation group A gene (Pig-A) as an endogenous reporter. The assay quantifies mutation in rat peripheral red blood cells (RBCs) by flow cytometric detection of cells negative for glycosylphosphatidyl inositol (GPI)-anchored protein surface markers. In this study, we examined the accumulation and persistence of Pig-A mutant RBCs in rats treated with N-ethyl-N-nitrosourea (ENU) using two dosing schedules. Male F344 rats were given single i.p. injections of 8.9, 35.6, or 142.4mg/kg ENU or four equal weekly doses totaling 35.6 or 142.4mg/kg ENU (8.9mg/kgx4 or 35.6mg/kgx4; split-dose groups). Before the treatment and through 26 weeks after the single dose or beginning the split-dose regimen, peripheral RBCs were collected and Pig-A mutant frequencies measured as RBCs negative for the GPI-anchored protein, CD59. Mean CD59-negative RBC frequencies in negative control rats ranged from 3.9x10 super(-) super(6) to 28.7x10 super(-) super(6) and displayed no time-related trend. With single ENU doses, CD59-negative RBC frequencies increased in a time- and dose-related manner. Maximum responses were observed beginning at 6 weeks post-treatment (57.3x10 super(-) super(6) in the 8.9mg/kg group; 186.9x10 super(-) super(6) in the 35.6mg/kg group; 759.2x10 super(-) super(6) in the 142.4mg/kg group), and these elevated mutant frequencies persisted to the last sampling time. In addition, splitting the dose of ENU into four weekly doses produced nearly the same mutant frequency as when given as a single dose: the maximum responses after four weekly doses of 8.9 or 35.6mg/kg were 176.8x10 super(-) super(6) and 683.3x10 super(-) super(6), respectively. These results indicate that ENU-induced Pig-A mutant RBCs accumulate in a near additive fashion in rats, and once present in the peripheral blood, persist for at least 6 months. These characteristics of Pig-A mutation could be important for detecting weak mutagens by repeated or subchronic/chronic dosing protocols. JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis AU - Miura, D AU - Dobrovolsky, V N AU - Kimoto, T AU - Kasahara, Y AU - Heflich, R H AD - U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States, robert.heflich@fda.hhs.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 86 EP - 92 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 677 IS - 1-2 SN - 1383-5718, 1383-5718 KW - Genetics Abstracts; Toxicology Abstracts KW - Mutagens KW - CD59 antigen KW - phosphatidylinositol KW - Inositol KW - Erythrocytes KW - Point mutation KW - Peripheral blood KW - Mutant frequency KW - Polysaccharides KW - Splitting KW - Mutagenesis KW - Flow cytometry KW - Complementation KW - Ethyl nitrosourea KW - Sampling KW - Mutation KW - Surface markers KW - G 07730:Development & Cell Cycle KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20110695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Accumulation+and+persistence+of+Pig-A+mutant+peripheral+red+blood+cells+following+treatment+of+rats+with+single+and+split+doses+of+N-ethyl-N-nitrosourea&rft.au=Miura%2C+D%3BDobrovolsky%2C+V+N%3BKimoto%2C+T%3BKasahara%2C+Y%3BHeflich%2C+R+H&rft.aulast=Miura&rft.aufirst=D&rft.date=2009-07-01&rft.volume=677&rft.issue=1-2&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2009.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Mutagens; CD59 antigen; phosphatidylinositol; Point mutation; Erythrocytes; Inositol; Mutant frequency; Peripheral blood; Polysaccharides; Splitting; Mutagenesis; Flow cytometry; Complementation; Ethyl nitrosourea; Sampling; Mutation; Surface markers DO - http://dx.doi.org/10.1016/j.mrgentox.2009.05.014 ER - TY - JOUR T1 - UVA-induced photomutagenicity of retinyl palmitate AN - 20096235; 10241751 JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis AU - Mei, N AU - Chen, T AU - Godar, DE AU - Moore, M M AD - National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA, nan.mei@fda.hhs.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 105 EP - 106 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 677 IS - 1-2 SN - 1383-5718, 1383-5718 KW - Toxicology Abstracts; Genetics Abstracts KW - Palmitic acid KW - Mutagenesis KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20096235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=UVA-induced+photomutagenicity+of+retinyl+palmitate&rft.au=Mei%2C+N%3BChen%2C+T%3BGodar%2C+DE%3BMoore%2C+M+M&rft.aulast=Mei&rft.aufirst=N&rft.date=2009-07-01&rft.volume=677&rft.issue=1-2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2009.05.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Palmitic acid; Mutagenesis DO - http://dx.doi.org/10.1016/j.mrgentox.2009.05.012 ER - TY - JOUR T1 - Development of a new dynamometer for measuring grip strength applied on a cylindrical handle AN - 20084725; 10186152 AB - The objective of this study is to enhance the understanding of the hand grip force applied to a cylindrical handle and to develop a new dynamometer for measuring maximum grip force or grip strength. Specifically, a 40 mm instrumented cylindrical handle with six measuring arms was developed. A theoretical model was proposed and used to analyze the principle of the measurement. Human test subjects were used in conducting two sets of experiments to evaluate the handle and to assess the measurement method. This study confirmed that some friction force exists in the grip-only action, but its level is not comparable with the normal force. This study also found that the friction force can stabilize the grip action and marginally increase the grip strength. No reliable correlation between the grip strengths measured with the 40 mm cylindrical handle and Jamar handle with a 47.6 mm span was observed. This suggests that grip strength measured with Jamar handle may not be reliably applicable to the design and risk assessment of some tools or machines with cylindrical handles. In contrast, the cylindrical handle proved to be able to determine the overall grip strength for a subject, as well as show the grip force distribution around the circumference of the handle. The handle is accurate with less than 4% error, and it demonstrates that the measurement is independent of the loading position along the handle. Therefore, this study concluded that this new dynamometer is suitable for measuring grip strength with sufficient precision. JF - Medical Engineering & Physics AU - Wimer, Bryan AU - Dong, Ren G AU - Welcome, Daniel E AU - Warren, Christopher AU - McDowell, Thomas W AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS L-2027, Morgantown, West Virginia 26505, USA, rkd6@cdc.gov Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 695 EP - 704 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 6 SN - 1350-4533, 1350-4533 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Grasping KW - Hand KW - Models KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20084725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Engineering+%26+Physics&rft.atitle=Development+of+a+new+dynamometer+for+measuring+grip+strength+applied+on+a+cylindrical+handle&rft.au=Wimer%2C+Bryan%3BDong%2C+Ren+G%3BWelcome%2C+Daniel+E%3BWarren%2C+Christopher%3BMcDowell%2C+Thomas+W&rft.aulast=Wimer&rft.aufirst=Bryan&rft.date=2009-07-01&rft.volume=31&rft.issue=6&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Medical+Engineering+%26+Physics&rft.issn=13504533&rft_id=info:doi/10.1016%2Fj.medengphy.2009.01.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Grasping; Risk assessment; Models; Hand DO - http://dx.doi.org/10.1016/j.medengphy.2009.01.009 ER - TY - JOUR T1 - S08: Ketamine-induced neurodevelopmental toxicity AN - 20066409; 10132061 JF - Experimental and Toxicologic Pathology AU - Paule, Merle G AD - FDA (Division of Neurotoxicology), National Center for Toxicological Research, USA Y1 - 2009/07// PY - 2009 DA - Jul 2009 SP - 392 EP - 393 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 61 IS - 4 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Toxicity KW - N3 11003:Developmental neuroscience KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20066409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=S08%3A+Ketamine-induced+neurodevelopmental+toxicity&rft.au=Paule%2C+Merle+G&rft.aulast=Paule&rft.aufirst=Merle&rft.date=2009-07-01&rft.volume=61&rft.issue=4&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2009.02.077 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Toxicity DO - http://dx.doi.org/10.1016/j.etp.2009.02.077 ER - TY - GEN T1 - The Health and Well-Being of Children: A Portrait of States and the Nation 2007. The National Survey of Children's Health 2007 AN - 1018480340; ED530918 AB - While data sources exist to measure and monitor the health of children in the United States, few take into account the many contexts in which children grow and develop, including their family and community environments. The National Survey of Children's Health (NSCH), conducted in 2007, addresses multiple aspects of children's health and well-being--including physical and mental health, health care, and social well-being--as well as aspects of the family and the neighborhood that can affect children's health, on both the national and State levels. The survey was supported and developed by the Health Resources and Services Administration's Maternal and Child Health Bureau and conducted by the Centers for Disease Control and Prevention's National Center for Health Statistics. This represents the second round of the NSCH, which was conducted for the first time in 2003. While many of the indicators reported here were reported in the 2003 survey, some of the survey questions have been revised to improve the quality of the data obtained. Those changes, however, may influence parents' responses. Therefore, this report notes where current findings cannot be compared with those reported in 2003. This chartbook presents indicators of the health and well-being of children, as well as the factors in the family environment and aspects of the neighborhood that may support or threaten families and children. These indicators present basic information on the health status and risk and protective factors experienced by children on the national level, and show the subpopulations who are at particular risk in each area. Children's use of preventive health care services was compared to the standards presented in the Bright Futures guidelines for children's health care. This is followed by analyses of key indicators on the State level for each of the 50 States and the District of Columbia. The Technical Appendix at the end of this book presents information about the survey methodology and sample in summary form. [For related reports, see "Children with Special Health Care Needs in Context: A Portrait of States and the Nation 2007. The National Survey of Children's Health 2007" (ED530916); "The Health and Well-Being of Children in Rural Areas: A Portrait of the Nation 2007. The National Survey of Children's Health" (ED530919); and "The Mental and Emotional Well-Being of Children: A Portrait of States and the Nation 2007. The National Survey of Children's Health" (ED530917).] Y1 - 2009/07// PY - 2009 DA - July 2009 SP - 105 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - United States KW - ERIC, Resources in Education (RIE) KW - Parent Influence KW - Well Being KW - Child Health KW - Family Relationship KW - Child Care KW - National Surveys KW - Nutrition KW - Peer Relationship KW - Health Promotion KW - Comparative Analysis KW - Public Health KW - Disabilities KW - Health Conditions KW - Social Development KW - Access to Health Care KW - Diseases KW - At Risk Persons KW - Family Environment KW - Religion KW - Neighborhoods KW - Mental Health KW - Child Safety KW - Health Needs KW - Dental Health KW - Prevention KW - Health Insurance KW - Recreational Activities KW - Early Intervention KW - Physical Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018480340?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatum. AN - 67437303; 19564919 AB - Methamphetamine (METH) is an illicit toxic psychostimulant which is widely abused. Its toxic effects depend on the release of excessive levels of dopamine (DA) that activates striatal DA receptors. Inhibition of DA-mediated neurotransmission by the DA D1 receptor antagonist, SCH23390, protects against METH-induced neuronal apoptosis. The initial purpose of the present study was to investigate, using microarray analyses, the influence of SCH23390 on transcriptional responses in the rat striatum caused by a single METH injection at 2 and 4 hours after drug administration. We identified 545 out of a total of 22,227 genes as METH-responsive. These include genes which are involved in apoptotic pathways, endoplasmic reticulum (ER) stress, and in transcription regulation, among others. Of these, a total of 172 genes showed SCH23390-induced inhibition of METH-mediated changes. Among these SCH23390-responsive genes were several genes that are regulated during ER stress, namely ATF3, HSP27, Hmox1, HSP40, and CHOP/Gadd153. The secondary goal of the study was to investigate the role of DA D1 receptor stimulation on the expression of genes that participate in ER stress-mediated molecular events. We thus used quantitative PCR to confirm changes in the METH-responsive ER genes identified by the microarray analyses. We also measured the expression of these genes and of ATF4, ATF6, BiP/GRP78, and of GADD34 over a more extended time course. SCH23390 attenuated or blocked METH-induced increases in the expression of the majority of these genes. Western blot analysis revealed METH-induced increases in the expression of the antioxidant protein, Hmox1, which lasted for about 24 hours after the METH injection. Additionally, METH caused DA D1 receptor-dependent transit of the Hmox1 regulator protein, Nrf2, from cytosolic into nuclear fractions where the protein exerts its regulatory functions. When taken together, these findings indicate that SCH23390 can provide protection against neuronal apoptosis by inhibiting METH-mediated DA D1 receptor-mediated ER stress in the rat striatum. Our data also suggest that METH-induced toxicity might be a useful model to dissect molecular mechanisms involved in ER stress-dependent events in the rodent brain. JF - PloS one AU - Jayanthi, Subramaniam AU - McCoy, Michael T AU - Beauvais, Genevieve AU - Ladenheim, Bruce AU - Gilmore, Kristi AU - Wood, William AU - Becker, Kevin AU - Cadet, Jean Lud AD - Molecular Neuropsychiatry Research Branch, National Institute of Drug Abuse, National Institutes of Health (NIH)/Department of Health and Human Services (DHHS), Intramural Research Program, Baltimore, MD, USA. Y1 - 2009/06/30/ PY - 2009 DA - 2009 Jun 30 SP - 1 VL - 4 IS - 6 KW - Benzazepines KW - 0 KW - Dopamine Agents KW - Receptors, Dopamine D1 KW - SCH 23390 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Benzazepines -- pharmacology KW - Apoptosis KW - Oligonucleotide Array Sequence Analysis KW - Synaptic Transmission -- drug effects KW - Dopamine Agents -- pharmacology KW - Models, Biological KW - Male KW - Neurons -- pathology KW - Methamphetamine -- pharmacology KW - Corpus Striatum -- drug effects KW - Receptors, Dopamine D1 -- metabolism KW - Endoplasmic Reticulum -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67437303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Methamphetamine+induces+dopamine+D1+receptor-dependent+endoplasmic+reticulum+stress-related+molecular+events+in+the+rat+striatum.&rft.au=Jayanthi%2C+Subramaniam%3BMcCoy%2C+Michael+T%3BBeauvais%2C+Genevieve%3BLadenheim%2C+Bruce%3BGilmore%2C+Kristi%3BWood%2C+William%3BBecker%2C+Kevin%3BCadet%2C+Jean+Lud&rft.aulast=Jayanthi&rft.aufirst=Subramaniam&rft.date=2009-06-30&rft.volume=4&rft.issue=6&rft.spage=e6092&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0006092 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-06-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2007 Aug 24;282(34):25088-99 [17597071] Mol Biol Cell. 2007 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Med. 2008 Oct;74(13):1526-39 [18937164] Nat Rev Drug Discov. 2008 Dec;7(12):1013-30 [19043451] Cancer Lett. 2009 Feb 8;274(1):40-6 [18829155] J Invest Surg. 2009 Jan-Feb;22(1):29-34 [19191155] FASEB J. 1999 Nov;13(14):2061-70 [10544189] Mol Biol Cell. 1999 Nov;10(11):3787-99 [10564271] Brain Res Dev Brain Res. 2000 Jan 3;119(1):139-53 [10648880] Brain Res. 2000 Apr 28;863(1-2):106-11 [10773198] Nat Cell Biol. 2000 Jun;2(6):326-32 [10854322] Mol Cell. 2000 May;5(5):897-904 [10882126] Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10242-7 [10963684] Free Radic Biol Med. 2000 Aug;29(3-4):254-62 [11035254] J Biochem. 2000 Sep;128(3):399-405 [10965038] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0006092 ER - TY - CPAPER T1 - Identification of Std Spread within a Sexual Network of Swingers: Swap Study T2 - 18th Conference of the International Society for Sexually Transmitted Diseases Research (2009 ISSTDR/BASHH) AN - 40265084; 5226035 JF - 18th Conference of the International Society for Sexually Transmitted Diseases Research (2009 ISSTDR/BASHH) AU - Niekamp, A M AU - Hoebe,, CJPA AU - Dukers-Muijrers,, NHTM Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - Sexually-transmitted diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40265084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+Conference+of+the+International+Society+for+Sexually+Transmitted+Diseases+Research+%282009+ISSTDR%2FBASHH%29&rft.atitle=Identification+of+Std+Spread+within+a+Sexual+Network+of+Swingers%3A+Swap+Study&rft.au=Niekamp%2C+A+M%3BHoebe%2C%2C+CJPA%3BDukers-Muijrers%2C%2C+NHTM&rft.aulast=Niekamp&rft.aufirst=A&rft.date=2009-06-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+Conference+of+the+International+Society+for+Sexually+Transmitted+Diseases+Research+%282009+ISSTDR%2FBASHH%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congrexnetwork.com/dbs/ISSTDR/files/symp_sci_prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Sti Outpatient Clinic Online- the Use and Efficacy of a Full-Scale Sti & Hiv Testing Application Online T2 - 18th Conference of the International Society for Sexually Transmitted Diseases Research (2009 ISSTDR/BASHH) AN - 40265028; 5225997 JF - 18th Conference of the International Society for Sexually Transmitted Diseases Research (2009 ISSTDR/BASHH) AU - Koekenbier, R H AU - Fennema, JSA AU - Leent van, E AU - Zuilhof, W AU - Veen van der, E AU - Davidovich, U Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40265028?accountid=14244 L2 - 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2010-05-03 ER - TY - CPAPER T1 - The Emergence of Hcv among Hiv-Positive Men Who Have Sex with Men Is Caused by High-Risk Sexual Behaviour Rather than Hcv Viral Change T2 - 18th Conference of the International Society for Sexually Transmitted Diseases Research (2009 ISSTDR/BASHH) AN - 40257710; 5226071 JF - 18th Conference of the International Society for Sexually Transmitted Diseases Research (2009 ISSTDR/BASHH) AU - Urbanus, A T AU - Prins, M AU - Schinkel, C J AU - de Vries, HJC AU - Coutinho, R A AU - van de Laar, TJW Y1 - 2009/06/28/ PY - 2009 DA - 2009 Jun 28 KW - Sexual behavior KW - Homosexuality KW - Risk groups KW - Sex KW - Hepatitis C virus KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40257710?accountid=14244 L2 - 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updated - 2010-05-03 ER - TY - JOUR T1 - FDA Regulation of Stem Cell-Based Products AN - 20764671; 10141217 AB - Cell self-renewal and the capacity to differentiate into multiple cell types (pluripotency) are biological attributes casting stem cells as attractive candidates for development of therapies targeting indications that involve functional restoration of damaged tissues. In the United States, clinical trials designed to demonstrate the safety and effectiveness of stem cell-based products are regulated by the U.S. Food and Drug Administration (FDA). To ensure that subjects enrolled in a clinical study involving stem cell-based products are not exposed to significant and unreasonable risk, the FDA reviews medical and scientific information that encompasses delineation of product-specific characteristics and preclinical testing to determine whether there is sufficient safety assurance to permit initiation of human clinical studies. JF - Science (Washington) AU - Fink, Donald W AD - Cell Therapy Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, Suite 200N, Mail Code HFM-720, Rockville, MD 20852-1448, USA., donald.fink@fda.hhs.gov Y1 - 2009/06/25/ PY - 2009 DA - 2009 Jun 25 SP - 1662 EP - 1663 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 324 IS - 5935 SN - 0036-8075, 0036-8075 KW - Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - clinical trials KW - Clinical trials KW - Stem cells KW - stem cells KW - Reviews KW - FDA KW - Permits KW - Drugs KW - W 30935:Food Biotechnology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20764671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=FDA+Regulation+of+Stem+Cell-Based+Products&rft.au=Fink%2C+Donald+W&rft.aulast=Fink&rft.aufirst=Donald&rft.date=2009-06-25&rft.volume=324&rft.issue=5935&rft.spage=1662&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1173712 L2 - http://www.sciencemag.org/cgi/reprint/324/5935/1662.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - FDA; clinical trials; Reviews; stem cells; Permits; Drugs; Clinical trials; Stem cells DO - http://dx.doi.org/10.1126/science.1173712 ER - TY - JOUR T1 - Regulatory perspective on the importance of ADME assessment of nanoscale material containing drugs. AN - 67283258; 19389437 AB - The promise of nanoscale material containing drug products to treat complex diseases is mounting. According to the literature, in addition to the liposomes, micelles, emulsions, there are novel drug delivery systems such as dendrimers and metal colloids at different stages of pre-clinical and clinical development. With the anticipation that more nanoscale material containing drug products will be submitted to the Food and Drug Administration (FDA) for approval in the future, FDA formed a Nanotechnology Task Force in 2006 to determine the critical regulatory issues regarding nanomaterials. As a result, all centers within the FDA are considering the development of guidance documents to address nanomaterial specific issues. It is well established in the literature that physico-chemical characterization (PCC) studies are crucial for nanomaterial containing drug products. However, this paper addresses the equally important topic of Absorption, Distribution, Metabolism and Excretion (ADME) studies for nanomaterials and provides examples of how physical properties affect biodistribution (i.e. the state of agglomeration, or aggregation, surface characteristics, stability of PEG). This paper also attempts to highlight some of the ADME study design issues related to nanomaterials such as the need for conducting biodistribution studies on each moiety of the multifunctional nanoparticles, dual labeled pharmacokinetic (PK) studies, and comparative PK studies on the free versus encapsulated drugs. In addition, this paper underlines the importance of long-term biodistribution and mass balance studies to understand the nanoparticle accumulation profile which may help to assess the safety and efficacy of the nanomaterial containing drug products. This review also lists some of the pre-clinical guidance documents that may help sponsors get started in developing data for inclusion in an initial investigational new drug application package for nanoscale material containing drug products. JF - Advanced drug delivery reviews AU - Zolnik, Banu S AU - Sadrieh, Nakissa AD - Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, 10903 New Hampshire Avenue, WO51, HFD-003, Silver Spring, MD 20993, USA. Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 SP - 422 EP - 427 VL - 61 IS - 6 KW - Liposomes KW - 0 KW - Pharmaceutical Preparations KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Nanoparticles -- adverse effects KW - Liposomes -- chemistry KW - Nanoparticles -- chemistry KW - Liposomes -- adverse effects KW - Pharmaceutical Preparations -- administration & dosage KW - Drug Approval -- methods KW - Nanostructures -- chemistry KW - Nanostructures -- adverse effects KW - Pharmaceutical Preparations -- chemistry KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67283258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+drug+delivery+reviews&rft.atitle=Regulatory+perspective+on+the+importance+of+ADME+assessment+of+nanoscale+material+containing+drugs.&rft.au=Zolnik%2C+Banu+S%3BSadrieh%2C+Nakissa&rft.aulast=Zolnik&rft.aufirst=Banu&rft.date=2009-06-21&rft.volume=61&rft.issue=6&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Advanced+drug+delivery+reviews&rft.issn=1872-8294&rft_id=info:doi/10.1016%2Fj.addr.2009.03.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-31 N1 - Date created - 2009-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.addr.2009.03.006 ER - TY - CPAPER T1 - The Role of HTA in Comparative Effectiveness Research and How This Influences Health Care Reform in the US T2 - 6th Annual Meeting of Health Technology Assessment International (HTAi 2009) AN - 40235650; 5200912 JF - 6th Annual Meeting of Health Technology Assessment International (HTAi 2009) AU - Slutsky, Jean Y1 - 2009/06/21/ PY - 2009 DA - 2009 Jun 21 KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40235650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+Meeting+of+Health+Technology+Assessment+International+%28HTAi+2009%29&rft.atitle=The+Role+of+HTA+in+Comparative+Effectiveness+Research+and+How+This+Influences+Health+Care+Reform+in+the+US&rft.au=Slutsky%2C+Jean&rft.aulast=Slutsky&rft.aufirst=Jean&rft.date=2009-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+Meeting+of+Health+Technology+Assessment+International+%28HTAi+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.htai2009.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of Nanomaterials with Human Blood Proteins and Platelets T2 - 2010 Central Regional Meeting of the American Chemical Society (CERMACS 2010) AN - 754298031; 5842493 JF - 2010 Central Regional Meeting of the American Chemical Society (CERMACS 2010) AU - De Paoli Lacerda, Silvia Y1 - 2009/06/16/ PY - 2009 DA - 2009 Jun 16 KW - Nanotechnology KW - Blood KW - Platelets KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754298031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2010%29&rft.atitle=Interaction+of+Nanomaterials+with+Human+Blood+Proteins+and+Platelets&rft.au=De+Paoli+Lacerda%2C+Silvia&rft.aulast=De+Paoli+Lacerda&rft.aufirst=Silvia&rft.date=2009-06-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cermacs2010.org/program/ACS-CR-Program%20Only.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Forensic Proteomics - Rapid Protein Analysis by MALDI-TOF/TOF MS with On- Plate Digestion and Stable Isotope Labeled Peptide Standards T2 - 2010 Central Regional Meeting of the American Chemical Society (CERMACS 2010) AN - 754294322; 5842518 JF - 2010 Central Regional Meeting of the American Chemical Society (CERMACS 2010) AU - Barry, Colin Y1 - 2009/06/16/ PY - 2009 DA - 2009 Jun 16 KW - Isotopes KW - Digestion KW - Proteomics KW - Forensic science KW - Peptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754294322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2010%29&rft.atitle=Forensic+Proteomics+-+Rapid+Protein+Analysis+by+MALDI-TOF%2FTOF+MS+with+On-+Plate+Digestion+and+Stable+Isotope+Labeled+Peptide+Standards&rft.au=Barry%2C+Colin&rft.aulast=Barry&rft.aufirst=Colin&rft.date=2009-06-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cermacs2010.org/program/ACS-CR-Program%20Only.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Urinary Analysis of Cyclophosphamide: Development and Comparison of Methods T2 - 2010 Central Regional Meeting of the American Chemical Society (CERMACS 2010) AN - 754286917; 5842641 JF - 2010 Central Regional Meeting of the American Chemical Society (CERMACS 2010) AU - Shoemaker, Dale AU - McLaurin, Jeffrey Y1 - 2009/06/16/ PY - 2009 DA - 2009 Jun 16 KW - Urine KW - Cyclophosphamide KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754286917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2010%29&rft.atitle=Urinary+Analysis+of+Cyclophosphamide%3A+Development+and+Comparison+of+Methods&rft.au=Shoemaker%2C+Dale%3BMcLaurin%2C+Jeffrey&rft.aulast=Shoemaker&rft.aufirst=Dale&rft.date=2009-06-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cermacs2010.org/program/ACS-CR-Program%20Only.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Validation of an HPLC-MS/MS Test Method To Quantify S-Benzylmercapturic Acid and S-Phenylmercapturic Acid in Human Urine T2 - 2010 Central Regional Meeting of the American Chemical Society (CERMACS 2010) AN - 754284721; 5842398 JF - 2010 Central Regional Meeting of the American Chemical Society (CERMACS 2010) AU - Bhymer, Clayton Y1 - 2009/06/16/ PY - 2009 DA - 2009 Jun 16 KW - Urine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754284721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2010%29&rft.atitle=Validation+of+an+HPLC-MS%2FMS+Test+Method+To+Quantify+S-Benzylmercapturic+Acid+and+S-Phenylmercapturic+Acid+in+Human+Urine&rft.au=Bhymer%2C+Clayton&rft.aulast=Bhymer&rft.aufirst=Clayton&rft.date=2009-06-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cermacs2010.org/program/ACS-CR-Program%20Only.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats. AN - 67358933; 19462990 AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat rheumatoid arthritis, osteoarthritis, acute pain, and fever. However, NSAIDs have side effects that include gastric erosions, ulceration, bleeding, and perforation, etc. Selective cyclooxygenase (COX)-2 inhibitors have been developed to avoid the adverse drug reaction of traditional NSAIDs. The COX-2 inhibitors have a different mechanism of action from nonselective COX inhibitors. In this study, pattern recognition analysis of the (1)H nuclear magnetic resonance (NMR) spectra of urine was performed to develop surrogate biomarkers related to the gastrointestinal (GI) damage induced by NSAIDs in rats. Urine was collected for 5 h after administering the following NSAIDs at high doses: celecoxib (133 mg kg(-1), p.o.), a COX-2-selective inhibitor; and indomethacin (25 mg kg(-1), p.o.) or ibuprofen (800 mg kg(-1), p.o.), nonselective COX inhibitors. The urine was analyzed using 600 M (1)H NMR for spectral binning and targeted profiling. The level of gastric damage in each animal was also determined. Indomethacin and ibuprofen caused severe gastric damage, but no lesions were observed in the celecoxib-treated rats. The (1)H NMR urine spectra were divided into spectral bins (0.04 ppm) for global profiling, and 36 endogenous metabolites were assigned for targeted profiling. Multivariate data analyses were carried out to recognize the spectral pattern of endogenous metabolites related to NSAIDs using partial least-squares discrimination analysis (PLS-DA). There were different clusterings of (1)H NMR spectra according to the gastric damage scores in global profiling. In targeted profiling, a few endogenous metabolites of allantoin, taurine, and dimethylamine were selected as putative biomarkers for the gastric damage induced by NSAIDs. The results of global and targeted profilings suggest that the gastric damage induced by NSAIDs can be screened in the preclinical stage of drug development using a current metabolomics study. In addition, the putative biomarkers might also be useful for predicting the risk of adverse effects caused by NSAIDs. JF - Analytical chemistry AU - Um, So Young AU - Chung, Myeon Woo AU - Kim, Kyu-Bong AU - Kim, Seon Hwa AU - Oh, Ji Seon AU - Oh, Hye Young AU - Lee, Hwa Jeong AU - Choi, Ki Hwan AD - Pharmacology Department, National Institute of Toxicological Research, Korea Food and Drug Administration, 194 Tongil-ro, Eunpyung-Ku, Seoul, Korea. Y1 - 2009/06/15/ PY - 2009 DA - 2009 Jun 15 SP - 4734 EP - 4741 VL - 81 IS - 12 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Pyrazoles KW - Sulfonamides KW - Celecoxib KW - JCX84Q7J1L KW - Ibuprofen KW - WK2XYI10QM KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Animals KW - Ibuprofen -- urine KW - Sulfonamides -- toxicity KW - Predictive Value of Tests KW - Indomethacin -- pharmacology KW - Sulfonamides -- metabolism KW - Rats KW - Pyrazoles -- metabolism KW - Cyclooxygenase 2 Inhibitors -- metabolism KW - Pyrazoles -- toxicity KW - Stomach -- pathology KW - Rats, Sprague-Dawley KW - Pyrazoles -- urine KW - Ibuprofen -- metabolism KW - Indomethacin -- metabolism KW - Cyclooxygenase 2 Inhibitors -- toxicity KW - Cyclooxygenase 2 Inhibitors -- urine KW - Least-Squares Analysis KW - Pattern Recognition, Automated KW - Indomethacin -- toxicity KW - Sulfonamides -- urine KW - Male KW - Ibuprofen -- toxicity KW - Metabolomics -- methods KW - Magnetic Resonance Spectroscopy -- methods KW - Anti-Inflammatory Agents, Non-Steroidal -- urine KW - Anti-Inflammatory Agents, Non-Steroidal -- toxicity KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67358933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+chemistry&rft.atitle=Pattern+recognition+analysis+for+the+prediction+of+adverse+effects+by+nonsteroidal+anti-inflammatory+drugs+using+1H+NMR-based+metabolomics+in+rats.&rft.au=Um%2C+So+Young%3BChung%2C+Myeon+Woo%3BKim%2C+Kyu-Bong%3BKim%2C+Seon+Hwa%3BOh%2C+Ji+Seon%3BOh%2C+Hye+Young%3BLee%2C+Hwa+Jeong%3BChoi%2C+Ki+Hwan&rft.aulast=Um&rft.aufirst=So&rft.date=2009-06-15&rft.volume=81&rft.issue=12&rft.spage=4734&rft.isbn=&rft.btitle=&rft.title=Analytical+chemistry&rft.issn=1520-6882&rft_id=info:doi/10.1021%2Fac9000282 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-14 N1 - Date created - 2009-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ac9000282 ER - TY - JOUR T1 - MacDonald et al. Respond to "search for preventable causes of cardiovascular disease". AN - 67325709; 19429880 JF - American journal of epidemiology AU - MacDonald, Leslie A AU - Cohen, Alex AU - Baron, Sherry AU - Burchfiel, Cecil M AD - Industry-wide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998, USA. lmacdonald@cdc.gov Y1 - 2009/06/15/ PY - 2009 DA - 2009 Jun 15 SP - 1426 EP - 1427 VL - 169 IS - 12 KW - Index Medicus KW - Socioeconomic Factors KW - Epidemiologic Methods KW - Risk Factors KW - Humans KW - Incidence KW - United States -- epidemiology KW - Occupational Exposure KW - Occupational Health KW - Public Health KW - Cardiovascular Diseases -- epidemiology KW - Cardiovascular Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67325709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=MacDonald+et+al.+Respond+to+%22search+for+preventable+causes+of+cardiovascular+disease%22.&rft.au=MacDonald%2C+Leslie+A%3BCohen%2C+Alex%3BBaron%2C+Sherry%3BBurchfiel%2C+Cecil+M&rft.aulast=MacDonald&rft.aufirst=Leslie&rft.date=2009-06-15&rft.volume=169&rft.issue=12&rft.spage=1426&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwp080 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-25 N1 - Date created - 2009-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwp080 ER - TY - JOUR T1 - Exposure to farm crops, livestock, and farm tasks and risk of glioma: the Upper Midwest Health Study. AN - 67324254; 19403843 AB - Some studies of brain cancer have found an excess risk for farmers. The National Institute for Occupational Safety and Health previously found no increased glioma risk for ever (vs. never) being exposed to pesticides on a farm among 798 cases and 1,175 population-based controls (adult (ages 18-80 years) nonmetropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin). For this analysis (1995-1998), 288 cases and 474 controls (or their proxies) who had lived on farms at age 18 years or after were asked about exposure to crops, livestock, and farm tasks. Logistic regression was used to calculate odds ratios adjusted for age, age group, sex, state, and education. Never immediately washing up (adjusted odds ratio (OR) = 3.08, 95% confidence interval (CI): 1.78, 5.34) or changing clothes (OR = 2.84, 95% CI: 1.04, 7.78) after applying pesticides was associated with increased glioma risk. Living on a farm on which corn, oats, soybeans, or hogs were raised was associated with decreased risk (corn-OR = 0.37, 95% CI: 0.20, 0.69; oats-OR = 0.63, 95% CI: 0.40, 1.00; soybeans-OR = 0.69, 95% CI: 0.48, 0.98; hogs-OR = 0.63, 95% CI: 0.43, 0.93). Negative associations may be due to chance or a "healthy farmer" effect. Farmers' increased risk of glioma may be due to work practices, other activities, or an inverse association with allergies (reported by other investigators). JF - American journal of epidemiology AU - Ruder, Avima M AU - Carreón, Tania AU - Butler, Mary Ann AU - Calvert, Geoffrey M AU - Davis-King, Karen E AU - Waters, Martha A AU - Schulte, Paul A AU - Mandel, Jack S AU - Morton, Roscoe F AU - Reding, Douglas J AU - Rosenman, Kenneth D AU - Brain Cancer Collaborative Study Group AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. amr2@cdc.gov ; Brain Cancer Collaborative Study Group Y1 - 2009/06/15/ PY - 2009 DA - 2009 Jun 15 SP - 1479 EP - 1491 VL - 169 IS - 12 KW - Organophosphorus Compounds KW - 0 KW - Pesticides KW - Index Medicus KW - Animals, Domestic KW - Young Adult KW - Animals KW - Odds Ratio KW - Agriculture -- methods KW - Humans KW - Aged KW - Risk Assessment KW - Logistic Models KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - Organophosphorus Compounds -- toxicity KW - Agriculture -- statistics & numerical data KW - Confidence Intervals KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Glioma -- chemically induced KW - Brain Neoplasms -- epidemiology KW - Agricultural Workers' Diseases -- etiology KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- chemically induced KW - Glioma -- etiology KW - Occupational Exposure -- adverse effects KW - Glioma -- epidemiology KW - Crops, Agricultural -- toxicity KW - Pesticides -- toxicity KW - Brain Neoplasms -- etiology KW - Brain Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67324254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Exposure+to+farm+crops%2C+livestock%2C+and+farm+tasks+and+risk+of+glioma%3A+the+Upper+Midwest+Health+Study.&rft.au=Ruder%2C+Avima+M%3BCarre%C3%B3n%2C+Tania%3BButler%2C+Mary+Ann%3BCalvert%2C+Geoffrey+M%3BDavis-King%2C+Karen+E%3BWaters%2C+Martha+A%3BSchulte%2C+Paul+A%3BMandel%2C+Jack+S%3BMorton%2C+Roscoe+F%3BReding%2C+Douglas+J%3BRosenman%2C+Kenneth+D%3BBrain+Cancer+Collaborative+Study+Group&rft.aulast=Ruder&rft.aufirst=Avima&rft.date=2009-06-15&rft.volume=169&rft.issue=12&rft.spage=1479&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwp075 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-25 N1 - Date created - 2009-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwp075 ER - TY - JOUR T1 - Occupation as socioeconomic status or environmental exposure? A survey of practice among population-based cardiovascular studies in the United States. AN - 67324218; 19429878 AB - Decisions about how occupation is used in epidemiologic research can affect conclusions about the importance of socioeconomic and environmental factors in explaining disparities for outcomes such as cardiovascular disease. A review of practices in the collection and use of occupational data was conducted among population-based cardiovascular studies in the United States. Studies were identified for review from the National Heart, Lung, and Blood Institute website and the biomedical database, Computer Retrieval of Information on Scientific Projects, by use of selected criteria. Data collection instruments and study publications were retrieved and reviewed for 30 of 33 studies (91%). Most of the studies (83%) collected at least descriptive occupational data, and more than half (60%) collected data on workplace hazards. The reviewed studies produced 80 publications in which occupational data were used in analyses, most often as an indicator of socioeconomic status. Authors rarely acknowledged known conceptual and empirical links among socioeconomic status, employment stability, and working conditions. Underutilization of data on workplace conditions was found. Existing data could be used more effectively to examine the contribution of work-related social and environmental conditions to the development of modifiable cardiovascular disease through multiple pathways. JF - American journal of epidemiology AU - MacDonald, Leslie A AU - Cohen, Alex AU - Baron, Sherry AU - Burchfiel, Cecil M AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226-1998, USA. lmacdonald@cdc.gov Y1 - 2009/06/15/ PY - 2009 DA - 2009 Jun 15 SP - 1411 EP - 1421 VL - 169 IS - 12 KW - Index Medicus KW - Socioeconomic Factors KW - Epidemiologic Methods KW - Risk Factors KW - Humans KW - United States -- epidemiology KW - Occupational Health KW - Cardiovascular Diseases -- etiology KW - Public Health KW - Social Class KW - Cardiovascular Diseases -- epidemiology KW - Occupational Exposure -- adverse effects KW - Cardiovascular Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67324218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Occupation+as+socioeconomic+status+or+environmental+exposure%3F+A+survey+of+practice+among+population-based+cardiovascular+studies+in+the+United+States.&rft.au=MacDonald%2C+Leslie+A%3BCohen%2C+Alex%3BBaron%2C+Sherry%3BBurchfiel%2C+Cecil+M&rft.aulast=MacDonald&rft.aufirst=Leslie&rft.date=2009-06-15&rft.volume=169&rft.issue=12&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwp082 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-25 N1 - Date created - 2009-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwp082 ER - TY - CPAPER T1 - Arsenic Removal by Adsorption: Investigation of Concurrent Uranium and Vanadium Adsorption and Implications of pH Adjustment T2 - 128th American Water Works Association's Annual Conference and Exposition (ACE 2009) AN - 40228721; 5199876 JF - 128th American Water Works Association's Annual Conference and Exposition (ACE 2009) AU - Cowman, Gretchen AU - Magnuson, Jim AU - Johnson, Adeline Y1 - 2009/06/14/ PY - 2009 DA - 2009 Jun 14 KW - Adsorption KW - Uranium KW - PH KW - Arsenic KW - Vanadium KW - PH effects KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40228721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=128th+American+Water+Works+Association%27s+Annual+Conference+and+Exposition+%28ACE+2009%29&rft.atitle=Arsenic+Removal+by+Adsorption%3A+Investigation+of+Concurrent+Uranium+and+Vanadium+Adsorption+and+Implications+of+pH+Adjustment&rft.au=Cowman%2C+Gretchen%3BMagnuson%2C+Jim%3BJohnson%2C+Adeline&rft.aulast=Cowman&rft.aufirst=Gretchen&rft.date=2009-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=128th+American+Water+Works+Association%27s+Annual+Conference+and+Exposition+%28ACE+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.awwa.org/files/ace09/UpdatedACE09ConfProgSchedule060909.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessment of Arsenic in a Municipal Water Supply in Potrerillos, Honduras T2 - 128th American Water Works Association's Annual Conference and Exposition (ACE 2009) AN - 40212165; 5199724 JF - 128th American Water Works Association's Annual Conference and Exposition (ACE 2009) AU - Cowman, Gretchen Y1 - 2009/06/14/ PY - 2009 DA - 2009 Jun 14 KW - Honduras KW - Municipal water supplies KW - Arsenic KW - Water supplies KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40212165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=128th+American+Water+Works+Association%27s+Annual+Conference+and+Exposition+%28ACE+2009%29&rft.atitle=Assessment+of+Arsenic+in+a+Municipal+Water+Supply+in+Potrerillos%2C+Honduras&rft.au=Cowman%2C+Gretchen&rft.aulast=Cowman&rft.aufirst=Gretchen&rft.date=2009-06-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=128th+American+Water+Works+Association%27s+Annual+Conference+and+Exposition+%28ACE+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.awwa.org/files/ace09/UpdatedACE09ConfProgSchedule060909.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Bacillus anthracis lethal toxin represses MMTV promoter activity through transcription factors. AN - 67308603; 19389405 AB - We have recently shown that the anthrax lethal toxin (LeTx) selectively represses nuclear hormone receptors. In this study, we found that LeTx repressed the activation of the mouse mammary tumor virus promoter related to overexpression of the transcription factors hepatocyte nuclear factor 3, octamer-binding protein 1, and c-Jun. LeTx transcriptional repression was associated with a decrease in the protein levels of these transcription factors in a lethal factor protease activity-dependent manner. Early administration of LeTx antagonists partially or completely abolished the repressive effects of LeTx. In contrast to the rapid cleavage of mitogen-activated protein kinase kinases by LeTx, the degradation of these transcription factors occurred at a relatively late stage after LeTx treatment. In addition, LeTx repressed phorbol-12-myristate-13-acetate-induced mouse mammary tumor virus promoter activity and phorbol 12-myristate 13-acetate induction of endogenous c-Jun protein. Collectively, these findings suggest that transcription factors are intracellular targets of LeTx and expand our understanding of the molecular action of LeTx at a later stage of low-dose exposure. JF - Journal of molecular biology AU - Kang, Zhigang AU - Webster Marketon, Jeanette I AU - Johnson, Antoinette AU - Sternberg, Esther M AD - Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N13 (MSC 9401), Bethesda, MD 20892-9401, USA. Y1 - 2009/06/12/ PY - 2009 DA - 2009 Jun 12 SP - 595 EP - 605 VL - 389 IS - 3 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Transcription Factor AP-1 KW - Transcription Factors KW - anthrax toxin KW - phorbolol myristate acetate KW - 56937-68-9 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Transcription Factor AP-1 -- antagonists & inhibitors KW - Promoter Regions, Genetic -- drug effects KW - COS Cells KW - Transcription Factor AP-1 -- metabolism KW - Tetradecanoylphorbol Acetate -- analogs & derivatives KW - Cercopithecus aethiops KW - Genes, Reporter KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Transcriptional Activation KW - Mammary Tumor Virus, Mouse -- genetics KW - Bacterial Toxins -- metabolism KW - Antigens, Bacterial -- metabolism KW - Transcription Factors -- antagonists & inhibitors KW - Transcription Factors -- metabolism KW - Bacillus anthracis -- metabolism KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67308603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Bacillus+anthracis+lethal+toxin+represses+MMTV+promoter+activity+through+transcription+factors.&rft.au=Kang%2C+Zhigang%3BWebster+Marketon%2C+Jeanette+I%3BJohnson%2C+Antoinette%3BSternberg%2C+Esther+M&rft.aulast=Kang&rft.aufirst=Zhigang&rft.date=2009-06-12&rft.volume=389&rft.issue=3&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=1089-8638&rft_id=info:doi/10.1016%2Fj.jmb.2009.04.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-08 N1 - Date created - 2009-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1991 Dec;11(12):5825-31 [1944265] Science. 1992 Mar 20;255(5051):1573-6 [1347958] Mol Cell Biol. 1995 Oct;15(10):5346-54 [7565684] Am J Physiol. 1996 May;270(5 Pt 2):F806-11 [8928842] Cell Mol Neurobiol. 1996 Apr;16(2):85-101 [8743962] Mol Endocrinol. 1996 Jul;10(7):794-800 [8813720] Curr Opin Cell Biol. 1997 Apr;9(2):240-6 [9069263] Science. 1998 May 1;280(5364):734-7 [9563949] Mol Cell Biol. 1998 Jun;18(6):3416-30 [9584182] Semin Immunol. 1998 Apr;10(2):155-63 [9618761] Mol Endocrinol. 1998 Oct;12(10):1487-98 [9773973] Genes Dev. 1999 Feb 15;13(4):495-504 [10049364] Lab Invest. 1999 Feb;79(2):83-94 [10068197] J Immunol. 1999 Mar 15;162(6):3527-33 [10092810] Mol Endocrinol. 1999 Apr;13(4):604-18 [10194766] Dev Biol. 1999 May 1;209(1):1-10 [10208738] Endocr Rev. 1999 Jun;20(3):321-44 [10368774] J Biol Chem. 2004 Nov 26;279(48):49857-67 [15381691] Infect Immun. 2005 Mar;73(3):1879-85 [15731093] Biochem Biophys Res Commun. 1993 Dec 30;197(3):1260-6 [8280142] Mol Microbiol. 1994 Sep;13(6):1093-100 [7854123] Eur J Immunol. 1995 May;25(5):1431-5 [7774647] Biochem Pharmacol. 1995 Aug 8;50(4):435-42 [7646547] Biochem Biophys Res Commun. 2008 Sep 19;374(2):288-93 [18625197] FEBS Lett. 1999 Nov 26;462(1-2):199-204 [10580119] Matrix Biol. 2000 May;19(2):91-6 [10842092] Biochem J. 2000 Dec 15;352 Pt 3:739-45 [11104681] Int J Med Microbiol. 2000 Oct;290(4-5):421-7 [11111921] Trends Endocrinol Metab. 2000 Sep;11(7):281-5 [10920385] Oncogene. 2001 Feb 8;20(6):669-76 [11314000] Histol Histopathol. 2001 Apr;16(2):595-601 [11332715] Oncogene. 2001 Apr 30;20(19):2465-75 [11402341] Annu Rev Microbiol. 2001;55:647-71 [11544370] Crit Rev Microbiol. 2001;27(3):167-200 [11596878] J Biol Chem. 2001 Oct 26;276(43):39885-91 [11518712] Emerg Infect Dis. 2001 Nov-Dec;7(6):933-44 [11747719] Infect Immun. 2002 Feb;70(2):544-60 [11796581] Ann Rheum Dis. 2002 Nov;61 Suppl 2:ii40-2 [12379619] Clin Exp Immunol. 2003 Feb;131(2):217-24 [12562380] Exp Cell Res. 2005 Apr 1;304(2):593-603 [15748903] Anal Biochem. 2005 Jun 1;341(1):33-9 [15866525] Infect Immun. 2005 Jul;73(7):4238-44 [15972515] Mol Cell Endocrinol. 2005 Sep 28;241(1-2):21-31 [15964137] Cell Microbiol. 2006 Jan;8(1):130-8 [16367872] Microb Pathog. 2006 Oct-Nov;41(4-5):157-67 [16950595] Carcinogenesis. 2007 May;28(5):1104-10 [17114644] Annu Rev Biochem. 2007;76:243-65 [17335404] Infect Immun. 2007 Nov;75(11):5443-52 [17709410] Infect Immun. 2008 Apr;76(4):1410-22 [18227166] Methods Enzymol. 2008;438:355-65 [18413261] J Immunol. 2008 Jun 1;180(11):7516-24 [18490752] Trends Microbiol. 2002 Jun;10(6):287-93 [12088665] Infect Immun. 1992 Jul;60(7):2581-7 [1612727] Mol Cell Biol. 1992 Jul;12(7):3247-61 [1535687] Cell. 1992 Nov 13;71(4):577-86 [1423615] J Virol. 1993 Jan;67(1):415-24 [8380087] Science. 1993 Feb 19;259(5098):1132-3 [8382375] Mol Endocrinol. 1993 Apr;7(4):570-84 [8388998] J Biol Chem. 2003 Mar 14;278(11):9402-6 [12522135] Doc Ophthalmol. 2003 Jan;106(1):25-9 [12675482] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5706-11 [12724519] Cesk Fysiol. 2003 Aug;52(3):118-28 [12931542] Annu Rev Cell Dev Biol. 2003;19:45-70 [14570563] Cell. 2003 Dec 12;115(6):751-63 [14675539] Nat Struct Mol Biol. 2004 Jan;11(1):60-6 [14718924] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):30-45 [15020043] Mol Cell Biol. 2004 Apr;24(7):3036-47 [15024090] Curr Opin Microbiol. 2004 Feb;7(1):19-24 [15036135] J Endocrinol. 2004 May;181(2):207-21 [15128270] Biochem Biophys Res Commun. 2004 Aug 27;321(3):601-5 [15358148] EMBO J. 1982;1(12):1613-9 [6327283] Infect Immun. 1986 Mar;51(3):795-800 [3081444] Infect Immun. 1986 May;52(2):356-63 [3084381] Nature. 1988 Aug 18;334(6183):629-31 [2457172] J Exp Med. 1989 Feb 1;169(2):431-45 [2783450] Proc Natl Acad Sci U S A. 1989 Apr;86(7):2374-8 [2538840] Proc Natl Acad Sci U S A. 1990 May;87(10):3977-81 [2160080] J Virol. 1990 Sep;64(9):4477-88 [2166825] Biochem Biophys Res Commun. 1990 Oct 15;172(1):348-56 [2171522] Cell. 1991 Feb 8;64(3):565-72 [1846780] Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2274-7 [1900940] FASEB J. 1991 Apr;5(7):2044-51 [2010057] Mol Cell Biol. 1991 May;11(5):2529-37 [1708094] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jmb.2009.04.030 ER - TY - CPAPER T1 - FDA Perspectives on Immune FunctionMonitoring in Clinical Trials T2 - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AN - 40186522; 5175884 JF - 2009 Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2009) AU - Siegel, Jeffery Y1 - 2009/06/11/ PY - 2009 DA - 2009 Jun 11 KW - Immune response KW - Clinical trials KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40186522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.atitle=FDA+Perspectives+on+Immune+FunctionMonitoring+in+Clinical+Trials&rft.au=Siegel%2C+Jeffery&rft.aulast=Siegel&rft.aufirst=Jeffery&rft.date=2009-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+Federation+of+Clinical+Immunology+Societies+%28FOCIS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/FOCIS/images/stories/FOCIS/PDFs/focis%202009%2 0final%20program%20for%20web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Alterations in the Gene Expression, Transcription Factors and Mitochondrial Membrane Proteome in MPTP-Induced Model of Parkinson's Disease T2 - 12th International Neurotoxicology Association Meeting (INA-12) AN - 42130938; 5149383 JF - 12th International Neurotoxicology Association Meeting (INA-12) AU - Ali, Syed Y1 - 2009/06/07/ PY - 2009 DA - 2009 Jun 07 KW - Parkinson's disease KW - Membranes KW - Gene expression KW - Movement disorders KW - Neurodegenerative diseases KW - Mitochondria KW - Transcription factors KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42130938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Neurotoxicology+Association+Meeting+%28INA-12%29&rft.atitle=Selective+Alterations+in+the+Gene+Expression%2C+Transcription+Factors+and+Mitochondrial+Membrane+Proteome+in+MPTP-Induced+Model+of+Parkinson%27s+Disease&rft.au=Ali%2C+Syed&rft.aulast=Ali&rft.aufirst=Syed&rft.date=2009-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Neurotoxicology+Association+Meeting+%28INA-12%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isas.co.il/ina-12/program02.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Aspects of Sex Differences in Drug Development T2 - Third Annual Meeting of the Organization for the Study of Sex Differences (OSSD 2009) AN - 42100866; 5136734 JF - Third Annual Meeting of the Organization for the Study of Sex Differences (OSSD 2009) AU - Uhl, Kathleen Y1 - 2009/06/04/ PY - 2009 DA - 2009 Jun 04 KW - Drug development KW - Sex differences KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42100866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+Annual+Meeting+of+the+Organization+for+the+Study+of+Sex+Differences+%28OSSD+2009%29&rft.atitle=Regulatory+Aspects+of+Sex+Differences+in+Drug+Development&rft.au=Uhl%2C+Kathleen&rft.aulast=Uhl&rft.aufirst=Kathleen&rft.date=2009-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+Annual+Meeting+of+the+Organization+for+the+Study+of+Sex+Differences+%28OSSD+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://data.memberclicks.com/site/ossd/2009%20OSSD%20Scientific%20Prog ram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Search for Sex Differences and Disease Etiology in Gene Expression Profiles of Systemic Lupus Erythematosus (SLE) Patients: Genomics Approach to Drug Development T2 - Third Annual Meeting of the Organization for the Study of Sex Differences (OSSD 2009) AN - 42094684; 5136733 JF - Third Annual Meeting of the Organization for the Study of Sex Differences (OSSD 2009) AU - Amur, Shashi Y1 - 2009/06/04/ PY - 2009 DA - 2009 Jun 04 KW - Etiology KW - Drug development KW - Gene expression KW - Systemic lupus erythematosus KW - Genomics KW - Sex differences KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42094684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+Annual+Meeting+of+the+Organization+for+the+Study+of+Sex+Differences+%28OSSD+2009%29&rft.atitle=A+Search+for+Sex+Differences+and+Disease+Etiology+in+Gene+Expression+Profiles+of+Systemic+Lupus+Erythematosus+%28SLE%29+Patients%3A+Genomics+Approach+to+Drug+Development&rft.au=Amur%2C+Shashi&rft.aulast=Amur&rft.aufirst=Shashi&rft.date=2009-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+Annual+Meeting+of+the+Organization+for+the+Study+of+Sex+Differences+%28OSSD+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://data.memberclicks.com/site/ossd/2009%20OSSD%20Scientific%20Prog ram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - RPRT T1 - Associations between Provider Training and Education and Other Quality Indicators in Low-Income Children's Primary Care Arrangements at 24 Months of Age. Research Brief. Publication #2009-18 AN - 864942154; ED517537 AB - This brief examines how provider training and education are related to parent- and provider-reported indicators of quality in home-based and center-based care for toddlers using data from a nationally representative sample of low-income children. The research addressed three research questions: What are the demographic characteristics that distinguish low-income families who use home-based versus center-based settings as the primary arrangement for their 24-month-olds? How do quality indicators differ in center-based versus home-based settings serving low-income children at 24 months of age? How do provider training and education predict other reported markers of quality, and do these relationships differ by type of setting? The first two questions were examined using bivariate analyses. The third question was examined using structural equation modeling. The authors address differences between home-based and center-based settings by modeling the relations between provider training and education and other markers of quality in the care setting separately for the two subsamples of children in home-based and center-based care arrangements within the Early Childhood Longitudinal Study--Birth Cohort. The differences in findings across these models are discussed. A technical appendix is included. (Contains 3 tables, 6 figures and 5 footnotes.) AU - Halle, Tamara AU - Forry, Nicole AU - Hair, Elizabeth AU - Westbrook, T'Pring AU - Dwyer, Kathleen Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 12 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Early Childhood Longitudinal Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Demography KW - Caregiver Training KW - Low Income Groups KW - Toddlers KW - Structural Equation Models KW - Child Caregivers KW - Child Care KW - Child Care Centers KW - Family (Sociological Unit) KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864942154?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - The Within-Year Concentration of Medical Care: Implications for Family Out-of-Pocket Expenditure Burdens AN - 839578574; 201103802 AB - Objective. To examine the within-year concentration of family health care and the resulting exposure of families to short periods of high expenditure burdens. Data Source. Household data from the pooled 2003 and 2004 Medical Expenditure Panel Survey (MEPS) yielding nationally representative estimates for the nonelderly civilian noninstitutionalized population. Study Design. The paper examines the within-year concentration of family medical care use and the frequency with which family out-of-pocket expenditures exceeded 20 percent of family income, computed at the annual, quarterly, and monthly levels. Principal Findings. On average among families with medical care, 49 percent of all (charge-weighted) care occurred in a single month, and 63 percent occurred in a single quarter). Nationally, 27 percent of the study population experienced at least 1 month in which out-of-pocket expenditures exceeded 20 percent of income. Monthly 20 percent burden rates were highest among the poor, at 43 percent, and were close to or above 30 percent for all but the highest income group (families above four times the federal poverty line). Conclusions. Within-year spikes in health care utilization can create financial pressures missed by conventional annual burden analyses. Within-year health-related financial pressures may be especially acute among lower-income families due to low asset holdings. Adapted from the source document. JF - Health Services Research AU - Selden, Thomas M AD - Department of Health and Human Services, Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 1029 EP - 1051 PB - Blackwell Publishers, Oxford UK VL - 44 IS - 3 SN - 0017-9124, 0017-9124 KW - Medical utilization expenditures burdens KW - Personal expenditure KW - Expenditure KW - Health care KW - Poverty KW - Concentration KW - Burden KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839578574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=The+Within-Year+Concentration+of+Medical+Care%3A+Implications+for+Family+Out-of-Pocket+Expenditure+Burdens&rft.au=Selden%2C+Thomas+M&rft.aulast=Selden&rft.aufirst=Thomas&rft.date=2009-06-01&rft.volume=44&rft.issue=3&rft.spage=1029&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2009.00963.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Health care; Expenditure; Personal expenditure; Concentration; Burden; Poverty DO - http://dx.doi.org/10.1111/j.1475-6773.2009.00963.x ER - TY - JOUR T1 - Analysis of seismic signatures from gas- and dust-based explosions at the Lake Lynn Experimental Mine AN - 742927115; 2010-065913 AB - Examination of seismic records during the time interval of the Sago Mine disaster in 2006 revealed a small amplitude signal possibly associated with an event in the mine. More needs to be understood about the seismicity from mine explosions to properly interpret critical seismic information. A seismic monitoring system located at NIOSH's Lake Lynn Experimental Mine has monitored experimental gas-and dust-based explosions and impact tests. The seismic signatures from these different events were analyzed using standard waveform analysis procedures. The magnitude of seismic energy during a gas and dust explosion was found to be more dependent on mine entry geometry and seal behavior rather than on the amount of explosive fuel present. The results suggest a large explosion that is not restricted can generate potentially the same magnitude as a small explosion that is restricted. JF - Mining Engineering AU - Murphy, M M AU - Iannacchione, A T AU - Westman, E C AU - Chapman, M C Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 91 EP - 98 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO VL - 61 IS - 6 SN - 0026-5187, 0026-5187 KW - United States KW - P-waves KW - geophones KW - geologic hazards KW - elastic waves KW - seismicity KW - sediments KW - induced earthquakes KW - body waves KW - monitoring KW - explosions KW - clastic sediments KW - mathematical models KW - gases KW - Allegheny County Pennsylvania KW - safety KW - dust KW - risk assessment KW - seismic waves KW - Pennsylvania KW - Lake Lynn Experimental Mine KW - earthquakes KW - Sago Mine KW - S-waves KW - 30:Engineering geology KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742927115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mining+Engineering&rft.atitle=Analysis+of+seismic+signatures+from+gas-+and+dust-based+explosions+at+the+Lake+Lynn+Experimental+Mine&rft.au=Murphy%2C+M+M%3BIannacchione%2C+A+T%3BWestman%2C+E+C%3BChapman%2C+M+C&rft.aulast=Murphy&rft.aufirst=M&rft.date=2009-06-01&rft.volume=61&rft.issue=6&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Mining+Engineering&rft.issn=00265187&rft_id=info:doi/ L2 - http://me.smenet.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 13 N1 - PubXState - CO N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - MIENAB N1 - SubjectsTermNotLitGenreText - Allegheny County Pennsylvania; body waves; clastic sediments; dust; earthquakes; elastic waves; explosions; gases; geologic hazards; geophones; induced earthquakes; Lake Lynn Experimental Mine; mathematical models; monitoring; P-waves; Pennsylvania; risk assessment; S-waves; safety; Sago Mine; sediments; seismic waves; seismicity; United States ER - TY - JOUR T1 - Development of a macrophage cell culture method to isolate and enrich Francisella tularensis from food matrices for subsequent detection by real-time PCR. AN - 67493175; 19610325 AB - Francisella tularensis is a gram-negative bacterium that can cause gastrointestinal or oropharyngeal tularemia in humans from ingestion of contaminated food or water. Despite the potential for accidental or intentional contamination of foods with F. tularensis, there are no techniques currently available to detect this organism in specific food matrices. In this study, a macrophage cell culture system is combined with real-time PCR to identify F. tularensis in food matrices. The method utilizes a mouse macrophage cell line (RAW 264.7) as host for the isolation and intracellular replication of F. tularensis. Exposure of macrophages to F. tularensis-contaminated food matrices results in uptake and intracellular replication of the bacteria, which can be subsequently detected by real-time PCR analysis of the DNA released from infected macrophage cell lysates. Macrophage monolayers were exposed to infant formula, liquid egg whites, and lettuce contaminated with varying quantities of F. tularensis. As few as 10 CFU/ml (or CFU per gram) F. tularensis was detected in infant formula and lettuce after 5 h postinfection. As few as 10 CFU/ml F. tularensis was detected in liquid egg whites after 18 h postinfection. Intracellular F. tularensis could also be isolated on Mueller-Hinton medium from lysates of macrophages infected with the bacteria in infant formula, liquid egg whites, and lettuce for subsequent confirmatory identification. This method is the first to successfully identify F. tularensis from select food matrices. JF - Journal of food protection AU - Day, J B AU - Whiting, R C AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-712, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA. james.day@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 1156 EP - 1164 VL - 72 IS - 6 SN - 0362-028X, 0362-028X KW - DNA, Bacterial KW - 0 KW - Index Medicus KW - Lettuce -- microbiology KW - Infant KW - Infant Formula KW - Consumer Product Safety KW - Humans KW - Colony Count, Microbial KW - Egg White -- microbiology KW - Cell Line KW - Cell Division KW - Polymerase Chain Reaction KW - Macrophages -- microbiology KW - Francisella tularensis -- isolation & purification KW - Food Contamination -- analysis KW - DNA, Bacterial -- analysis KW - Francisella tularensis -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67493175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Development+of+a+macrophage+cell+culture+method+to+isolate+and+enrich+Francisella+tularensis+from+food+matrices+for+subsequent+detection+by+real-time+PCR.&rft.au=Day%2C+J+B%3BWhiting%2C+R+C&rft.aulast=Day&rft.aufirst=J&rft.date=2009-06-01&rft.volume=72&rft.issue=6&rft.spage=1156&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-01 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life. AN - 67466100; 19590677 AB - Exposure to endocrine-disrupting chemicals during critical developmental periods causes adverse consequences later in life; an example is prenatal exposure to the pharmaceutical diethylstilbestrol (DES). Bisphenol A (BPA), an environmental estrogen used in the synthesis of plastics, is of concern because its chemical structure resembles that of DES, and it is a "high-volume production" chemical with widespread human exposure. In this study we investigated whether prenatal BPA causes long-term adverse effects in female reproductive tissues in an experimental animal model previously shown useful in studying effects of prenatal DES. Timed pregnant CD-1 mice were treated on days 9-16 of gestation with BPA (0.1, 1, 10, 100, or 1,000 mug/kg/day). After delivery, pups were held for 18 months; reproductive tissues were then evaluated. Ovarian cysts were significantly increased in the 1-mug/kg BPA group; ovarian cyst-adenomas were seen in the other three BPA-treated groups but not in corn-oil controls. We observed increased progressive proliferative lesions of the oviduct after BPA treatment, similar to those described in response to DES. Further, although not statistically different from the controls, prominent mesonephric (Wolffian) remnants and squamous metaplasia of the uterus, as well as vaginal adenosis, were present in BPA-treated mice, similar to lesions reported following DES treatment. More severe pathologies observed in some BPA-treated animals included atypical hyperplasia and stromal polyps of the uterus; sarcoma of the uterine cervix; and mammary adenocarcinoma. We did not observe these lesions in controls. These data suggest that BPA causes long-term adverse reproductive and carcinogenic effects if exposure occurs during critical periods of differentiation. JF - Environmental health perspectives AU - Newbold, Retha R AU - Jefferson, Wendy N AU - Padilla-Banks, Elizabeth AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. newbold1@niehs.nih.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 879 EP - 885 VL - 117 IS - 6 KW - Benzhydryl Compounds KW - 0 KW - Endocrine Disruptors KW - Phenols KW - Water Pollutants, Chemical KW - Diethylstilbestrol KW - 731DCA35BT KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - uterus KW - ovary KW - DES KW - development KW - carcinogenesis KW - endocrine disruptors KW - toxicology KW - BPA KW - diethylstilbestrol KW - reproduction KW - Endocrine Disruptors -- toxicity KW - Animals KW - Diethylstilbestrol -- toxicity KW - Ovary -- drug effects KW - Mice KW - Uterus -- drug effects KW - Female KW - Pregnancy KW - Reproduction -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Phenols -- toxicity KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67466100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Prenatal+exposure+to+bisphenol+a+at+environmentally+relevant+doses+adversely+affects+the+murine+female+reproductive+tract+later+in+life.&rft.au=Newbold%2C+Retha+R%3BJefferson%2C+Wendy+N%3BPadilla-Banks%2C+Elizabeth&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2009-06-01&rft.volume=117&rft.issue=6&rft.spage=879&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0800045 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-23 N1 - Date created - 2009-07-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Matern Child Nutr. 2005 Jul;1(3):130-41 [16881892] Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12033-8 [16882715] Mol Endocrinol. 2006 Sep;20(9):2141-55 [16613991] Environ Health Perspect. 2007 Jan;115(1):80-6 [17366824] Reprod Toxicol. 2007 Apr-May;23(3):383-90 [17123778] Reprod Toxicol. 2007 Apr-May;23(3):290-6 [17321108] Reprod Toxicol. 2007 Aug-Sep;24(2):178-98 [17628395] Reprod Toxicol. 2007 Aug-Sep;24(2):253-8 [17804194] Horm Behav. 2006 Jun;50(1):85-93 [16540110] Reprod Toxicol. 2007 Aug-Sep;24(2):139-77 [17825522] J Atheroscler Thromb. 2007 Oct;14(5):245-52 [17938543] Environ Health Perspect. 2008 Jan;116(1):39-44 [18197297] Epidemiology. 2008 Mar;19(2):251-7 [18223485] Reprod Toxicol. 2008 Feb;25(2):169-76 [18295446] Environ Health Perspect. 1993 Oct;101(5):372-7 [8119245] Development. 1994 Feb;120(2):335-45 [7908629] Am J Pathol. 1986 Sep;124(3):405-11 [3766701] Cancer Res. 1990 Dec 1;50(23):7677-81 [2174729] Carcinogenesis. 1992 Feb;13(2):145-51 [1740003] Eur J Cancer. 1992;28A(6-7):1182-9 [1627392] Eur J Cancer. 1992;29A(1):149-55 [1445734] Environ Health Perspect. 1992 Nov;98:39-43 [1486860] Environ Health Perspect. 1995 Jun;103(6):608-12 [7556016] Prog Clin Biol Res. 1996;394:175-82 [8778796] Prog Clin Biol Res. 1996;394:425-45 [8778808] Environ Health Perspect. 1996 Mar;104(3):298-305 [8919768] Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2056-61 [9050904] Biol Reprod. 1997 Dec;57(6):1338-45 [9408238] Carcinogenesis. 1997 Dec;18(12):2293-8 [9450472] Int J Cancer. 1998 Jan 19;75(2):290-4 [9462721] Dev Biol. 1998 May 15;197(2):141-54 [9630742] Nat Genet. 1998 Nov;20(3):228-30 [9806537] J Perinatol. 2008 Apr;28(4):258-63 [18273031] Nature. 1999 Oct 21;401(6755):763-4 [10548101] Lab Anim Sci. 1999 Oct;49(5):530-6 [10551455] Cancer Res. 2000 Jan 15;60(2):235-7 [10667565] Int J Cancer. 2000 Apr 15;86(2):151-4 [10738239] Environ Health Perspect. 2000 Oct;108 Suppl 5:769-73 [11035980] Cancer Res. 2001 Jun 1;61(11):4325-8 [11389053] Environ Health Perspect. 2001 Jul;109(7):675-80 [11485865] Biol Reprod. 2001 Oct;65(4):1215-23 [11566746] Biochem Biophys Res Commun. 2002 Feb 15;291(1):76-8 [11829464] Neoplasia. 2002 Mar-Apr;4(2):98-102 [11896564] Environ Health Perspect. 2002 Apr;110(4):427-31 [11940462] Reprod Toxicol. 2002 Mar-Apr;16(2):117-22 [11955942] Toxicol Pathol. 2002 Sep-Oct;30(5):611-6 [12371671] Environ Health Perspect. 2002 Nov;110(11):A703-7 [12417499] Evol Dev. 2003 Jan-Feb;5(1):67-75 [12492412] Curr Biol. 2003 Apr 1;13(7):546-53 [12676084] Obes Res. 2003 Apr;11(4):496-506 [12690076] Regul Toxicol Pharmacol. 2003 Jun;37(3):407-8; 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AN - 67462870; 19583115 JF - The Alabama nurse AU - Bell, Jennifer AU - Collins, Jim AU - Galinsky, Traci L AU - Waters, Thomas R AD - Analysis and Field Evaluations Branch, NIOSH Division of Safety Research, USA. PY - 2009 SP - 16 VL - 36 IS - 2 SN - 0002-4317, 0002-4317 KW - Nursing KW - United States KW - Humans KW - National Institute for Occupational Safety and Health (U.S.) KW - Moving and Lifting Patients -- methods KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Back Injuries -- prevention & control KW - Back Injuries -- etiology KW - Moving and Lifting Patients -- adverse effects KW - Safety Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67462870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Alabama+nurse&rft.atitle=Preventing+back+injuries.&rft.au=Bell%2C+Jennifer%3BCollins%2C+Jim%3BGalinsky%2C+Traci+L%3BWaters%2C+Thomas+R&rft.aulast=Bell&rft.aufirst=Jennifer&rft.date=2009-06-01&rft.volume=36&rft.issue=2&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=The+Alabama+nurse&rft.issn=00024317&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-28 N1 - Date created - 2009-07-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The analgesic effect of decursinol. AN - 67415537; 19557373 AB - Although decursinol, which is one of the coumarins purified from the dried roots of Angelica gigas Nakai, was previously demonstrated to have antinociceptive effects on various mouse pain models such as tail-flick, hot-plate, formalin, writhing, and several cytokine-induced pain tests, the possible involvement of its analgesic effects and non-steroidal anti-inflammatory drugs (NSAIDs) has not been clearly elucidated yet. In this study, we characterized the possible interaction between decursinol and aspirin or acetaminophen in the writhing test. The antinociceptive effects of decursinol were observed at an orally-administered dose of 50 mg/kg but not at 25 or 10 mg/kg. In addition, the analgesic effects of aspirin (ASA) and acetaminophen (APAP) were shown at an orally-administered dose of 200 mg/kg but not at 50 or 100 mg/kg. We examined the effects of decursinol on the ASA or APAP at sub-analgesic doses. Although the co-administration of decursinol and ASA did not show any differences at doses of 10 or 25 mg/kg and 50 or 100 mg/kg, respectively, synergistic effects between decursinol and APAP were observed in the group of decursinol (25 mg/kg) and APAP (100 mg/kg) co-administration. These results indicated that the analgesic effect of decursinol might be involved in supraspinal cyclooxygenase regulation that might be overlapped with APAP-induced analgesic mechanisms rather than systemic or peripheral prostaglandin modulation. JF - Archives of pharmacal research AU - Seo, Young-Jun AU - Kwon, Min-Soo AU - Park, Soo-Hyun AU - Sim, Yun-Beom AU - Choi, Seung-Min AU - Huh, Gyung-He AU - Lee, Jin-Koo AU - Suh, Hong-Won AD - Division of Recombinant Products, Biopharmaceutical Bureau, Korea Food and Drug Administration, Seoul 122-704, Korea. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 937 EP - 943 VL - 32 IS - 6 SN - 0253-6269, 0253-6269 KW - Analgesics KW - 0 KW - Benzopyrans KW - Butyrates KW - Plant Extracts KW - Acetaminophen KW - 362O9ITL9D KW - decursin KW - 5928-25-6 KW - Acetic Acid KW - Q40Q9N063P KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Acetaminophen -- administration & dosage KW - Animals KW - Mice, Inbred ICR KW - Disease Models, Animal KW - Mice KW - Acetaminophen -- pharmacology KW - Drug Therapy, Combination KW - Plant Extracts -- pharmacology KW - Aspirin -- administration & dosage KW - Angelica KW - Drug Synergism KW - Aspirin -- pharmacology KW - Male KW - Pain -- drug therapy KW - Butyrates -- administration & dosage KW - Pain -- chemically induced KW - Benzopyrans -- administration & dosage KW - Butyrates -- pharmacology KW - Benzopyrans -- pharmacology KW - Analgesics -- pharmacology KW - Butyrates -- isolation & purification KW - Analgesics -- administration & dosage KW - Benzopyrans -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67415537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pharmacal+research&rft.atitle=The+analgesic+effect+of+decursinol.&rft.au=Seo%2C+Young-Jun%3BKwon%2C+Min-Soo%3BPark%2C+Soo-Hyun%3BSim%2C+Yun-Beom%3BChoi%2C+Seung-Min%3BHuh%2C+Gyung-He%3BLee%2C+Jin-Koo%3BSuh%2C+Hong-Won&rft.aulast=Seo&rft.aufirst=Young-Jun&rft.date=2009-06-01&rft.volume=32&rft.issue=6&rft.spage=937&rft.isbn=&rft.btitle=&rft.title=Archives+of+pharmacal+research&rft.issn=02536269&rft_id=info:doi/10.1007%2Fs12272-009-1617-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-10 N1 - Date created - 2009-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s12272-009-1617-z ER - TY - JOUR T1 - Lactational coumestrol exposure increases ovarian apoptosis in adult rats. AN - 67363777; 19165469 AB - This study is the first to examine the increased apoptosis in the adult rat ovary after lactational exposure to coumestrol (COU), a potent phytoestrogen. Lactating dams were gavaged at doses of 0.01, 0.1, 1, and 10 mg/kg COU during the lactation period and the reproductive effects of female pups were investigated in young adults. Rats were sacrificed at postnatal days (PND) 81-84. Ovarian weights were reduced significantly at 0.1 and 1.0 mg/kg COU. The reduction in the ovarian weight occurred in parallel with an increase in the apoptosis at PND 135-140. A marked dose-dependent increase in the expressions of active caspase-3 and -7 was observed in ovarian granulosa cells. Immunostaining for active caspase-3 and the TUNEL staining of apoptotic cells were also increased in ovaries exposed to COU in a dose-dependent manner. These results suggest new sights into the effect of lactational exposure to COU on the female reproductive health. JF - Archives of toxicology AU - Moon, Hyun-Ju AU - Seok, Ji Hyun AU - Kim, Soon Sun AU - Rhee, Gyu Seek AU - Lee, Rhee Da AU - Yang, Jun Young AU - Chae, Soo Yeong AU - Kim, Seung Hee AU - Kim, Ji Young AU - Chung, Jin-Yong AU - Kim, Jong-Min AU - Chung, Soo Youn AD - Reproductive and Developmental Toxicology Division, National Institute of Toxicological Research, Korea Food and Drug Administration, 194 Tongil-ro, Eunpyung-gu, Seoul 122-704, South Korea. mhj1612@kfda.go.kr Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 601 EP - 608 VL - 83 IS - 6 KW - Phytoestrogens KW - 0 KW - Caspase 3 KW - EC 3.4.22.- KW - Caspase 7 KW - Coumestrol KW - V7NW98OB34 KW - Index Medicus KW - Animals, Suckling KW - Animals KW - Granulosa Cells -- drug effects KW - Reproduction -- drug effects KW - Caspase 7 -- metabolism KW - Dose-Response Relationship, Drug KW - Caspase 3 -- drug effects KW - Granulosa Cells -- metabolism KW - Pregnancy KW - Rats KW - In Situ Nick-End Labeling KW - Animals, Newborn KW - Rats, Sprague-Dawley KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Caspase 7 -- drug effects KW - Female KW - Organ Size -- drug effects KW - Caspase 3 -- metabolism KW - Coumestrol -- administration & dosage KW - Phytoestrogens -- toxicity KW - Ovary -- cytology KW - Coumestrol -- toxicity KW - Ovary -- drug effects KW - Apoptosis -- drug effects KW - Phytoestrogens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67363777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Lactational+coumestrol+exposure+increases+ovarian+apoptosis+in+adult+rats.&rft.au=Moon%2C+Hyun-Ju%3BSeok%2C+Ji+Hyun%3BKim%2C+Soon+Sun%3BRhee%2C+Gyu+Seek%3BLee%2C+Rhee+Da%3BYang%2C+Jun+Young%3BChae%2C+Soo+Yeong%3BKim%2C+Seung+Hee%3BKim%2C+Ji+Young%3BChung%2C+Jin-Yong%3BKim%2C+Jong-Min%3BChung%2C+Soo+Youn&rft.aulast=Moon&rft.aufirst=Hyun-Ju&rft.date=2009-06-01&rft.volume=83&rft.issue=6&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-008-0400-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-31 N1 - Date created - 2009-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Reproduction. 2002 Nov;124(5):659-65 [12417004] Endocrinology. 2002 Apr;143(4):1495-501 [11897708] Oncogene. 2003 Nov 24;22(53):8543-67 [14634618] Anticancer Res. 2004 Mar-Apr;24(2B):795-800 [15161029] Reprod Biol Endocrinol. 2003 Aug 27;1:59 [12967350] Reprod Toxicol. 2004 Aug-Sep;18(6):803-11 [15279878] Endocrinology. 1976 Dec;99(6):1562-70 [187412] Endocrinology. 1979 Mar;104(3):765-73 [220021] Physiol Rev. 1980 Jan;60(1):51-89 [6243782] Proc Soc Exp Biol Med. 1981 Jun;167(2):237-41 [7232429] Environ Health Perspect. 1987 Nov;75:25-7 [3319561] J Toxicol Environ Health. 1990 Jun;30(2):105-22 [2355401] Endocrinology. 1991 May;128(5):2663-5 [2019275] Am J Clin Nutr. 1991 Dec;54(6):1093-100 [1659780] Reprod Toxicol. 1990;4(2):127-35 [2136027] Endocrinology. 1992 Oct;131(4):1670-6 [1396312] Endocrinology. 1993 Nov;133(5):2204-12 [8404672] Biol Reprod. 1993 Nov;49(5):1117-21 [8286579] J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):205-12 [8049151] Proc Soc Exp Biol Med. 1995 Jan;208(1):60-6 [7892297] Proc Soc Exp Biol Med. 1995 Jan;208(1):82-6 [7892301] Endocr Rev. 1994 Dec;15(6):707-24 [7705278] Cancer Res. 1995 Jun 15;55(12):2487-9 [7780952] Annu Rev Physiol. 1997;59:349-63 [9074768] Circulation. 1997 Mar 18;95(6):1505-14 [9118519] Clin Immunol Immunopathol. 1997 Mar;82(3):258-62 [9073549] Cell. 1997 Apr 18;89(2):175-84 [9108473] Annu Rev Nutr. 1997;17:353-81 [9240932] Biol Reprod. 1997 Aug;57(2):420-7 [9241059] J Clin Endocrinol Metab. 1997 Sep;82(9):3128-35 [9284757] Biol Reprod. 1997 Oct;57(4):813-21 [9314585] Rev Reprod. 1996 Sep;1(3):162-72 [9414454] J Soc Gynecol Investig. 1995 May-Jun;2(3):565-73 [9420860] J Cell Biol. 1999 Jan 25;144(2):281-92 [9922454] J Biol Chem. 1999 Feb 19;274(8):5053-60 [9988752] J Nutr. 1999 Mar;129(3):758S-767S [10082786] Acta Histochem. 1999 Feb;101(1):103-12 [10093644] Cell Death Differ. 1999 Feb;6(2):99-104 [10200555] Biochem Biophys Res Commun. 1999 Jul 5;260(2):410-5 [10403783] Biochem J. 2004 Dec 1;384(Pt 2):201-32 [15450003] Brain Res Bull. 2005 Jan 15;64(5):449-54 [15607833] Biol Reprod. 2005 Oct;73(4):798-806 [15930323] Science. 2006 Feb 10;311(5762):847-51 [16469926] Int J Food Sci Nutr. 2006 Aug-Sep;57(5-6):325-44 [17135023] Cell Death Differ. 2007 Jan;14(1):32-43 [17082813] Anticancer Drugs. 2007 Jul;18(6):649-57 [17762393] Metab Eng. 2007 Sep-Nov;9(5-6):452-64 [17892962] Mol Cells. 2007 Oct 31;24(2):261-7 [17978580] Biochem Pharmacol. 2008 Mar 1;75(5):1161-9 [18184606] Neuroreport. 1998 Mar 9;9(4):593-7 [9559922] Biol Reprod. 1998 Jun;58(6):1533-9 [9623616] Endocrinology. 1998 Oct;139(10):4252-63 [9751507] Biochem Biophys Res Commun. 2000 Feb 5;268(1):192-200 [10652235] Clin Cancer Res. 2000 Jan;6(1):230-6 [10656454] Biol Reprod. 2000 Mar;62(3):589-98 [10684799] Environ Health Perspect. 2000 Jun;108 Suppl 3:491-503 [10852849] Annu Rev Biochem. 1999;68:383-424 [10872455] Environ Health Perspect. 2000 Jul;108(7):631-4 [10903616] Endocrinology. 2001 Jun;142(6):2468-80 [11356696] Biol Reprod. 2001 Jul;65(1):87-93 [11420227] Mol Hum Reprod. 2002 Mar;8(3):228-36 [11870230] Horm Behav. 2003 Aug;44(2):140-5 [13129486] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00204-008-0400-0 ER - TY - JOUR T1 - Physiological burden associated with the use of filtering facepiece respirators (N95 masks) during pregnancy. AN - 67351129; 19514822 AB - The purpose of this study was to review the available literature regarding the physiological burden imposed on pregnant women by their wearing filtering facepiece respirators. A medical literature search was conducted using MEDLINE (1996-2008) for English language articles, bibliographies of retrieved articles, electronic references from medical and governmental agency sources, and selected textbook articles. Two hundred thirty-four articles from the medical literature and 267 electronic references were retrieved, of which 51 articles from the medical literature, 25 electronic references, and 2 textbook articles were selected for data acquisition. Very little rigorous scientific data exist on the physiological burden associated with the use of filtering facepiece respirators by pregnant women, and no definitive conclusions can be reached at this time. Although studies are warranted, they may be difficult to undertake because of health concerns and potential liability associated with the use of pregnant women in medical research. Computer modeling that incorporates features of pulmonary function in pregnancy might offer an alternative to human studies. Filtering facepiece respirators developed to meet the respiratory limitations of pregnant wearers might offer a universal design that would improve the comfort and tolerability for all users. Alternative strategies that limit the pregnant woman's contact with potentially infectious agents (e.g., job reassignment, working from home) may have to be employed in certain circumstances. JF - Journal of women's health (2002) AU - Roberge, Raymond Joseph AD - National Personal Protective Technology Laboratory/National Institute for Occupational Safety and Health, Technology Research Branch, P.O. Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA. dtn0@cdc.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 819 EP - 826 VL - 18 IS - 6 KW - Air Pollutants KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Air Pollutants -- adverse effects KW - Female KW - Pregnancy KW - Respiratory Protective Devices -- statistics & numerical data KW - Masks -- statistics & numerical data KW - Pregnancy Complications, Infectious -- prevention & control KW - Masks -- adverse effects KW - Inhalation Exposure -- prevention & control KW - Infection Control -- methods KW - Inhalation Exposure -- statistics & numerical data KW - Respiratory Protective Devices -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67351129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+women%27s+health+%282002%29&rft.atitle=Physiological+burden+associated+with+the+use+of+filtering+facepiece+respirators+%28N95+masks%29+during+pregnancy.&rft.au=Roberge%2C+Raymond+Joseph&rft.aulast=Roberge&rft.aufirst=Raymond&rft.date=2009-06-01&rft.volume=18&rft.issue=6&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Journal+of+women%27s+health+%282002%29&rft.issn=1931-843X&rft_id=info:doi/10.1089%2Fjwh.2008.1072 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-04 N1 - Date created - 2009-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/jwh.2008.1072 ER - TY - JOUR T1 - Predicting drug-drug interactions: an FDA perspective. AN - 67325213; 19418230 AB - Pharmacokinetic drug interactions can lead to serious adverse events, and the evaluation of a new molecular entity's drug-drug interaction potential is an integral part of drug development and regulatory review prior to its market approval. Alteration of enzyme and/or transporter activities involved in the absorption, distribution, metabolism, or excretion of a new molecular entity by other concomitant drugs may lead to a change in exposure leading to altered response (safety or efficacy). Over the years, various in vitro methodologies have been developed to predict drug interaction potential in vivo. In vitro study has become a critical first step in the assessment of drug interactions. Well-executed in vitro studies can be used as a screening tool for the need for further in vivo assessment and can provide the basis for the design of subsequent in vivo drug interaction studies. Besides in vitro experiments, in silico modeling and simulation may also assist in the prediction of drug interactions. The recent FDA draft drug interaction guidance highlighted the in vitro models and criteria that may be used to guide further in vivo drug interaction studies and to construct informative labeling. This report summarizes critical elements in the in vitro evaluation of drug interaction potential during drug development and uses a case study to highlight the impact of in vitro information on drug labeling. JF - The AAPS journal AU - Zhang, Lei AU - Zhang, Yuanchao Derek AU - Zhao, Ping AU - Huang, Shiew-Mei AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Rm 3188, Bldg 51, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 300 EP - 306 VL - 11 IS - 2 KW - Carrier Proteins KW - 0 KW - Pharmaceutical Preparations KW - Index Medicus KW - United States KW - Animals KW - Pharmaceutical Preparations -- metabolism KW - Computer Simulation KW - Carrier Proteins -- metabolism KW - Humans KW - Guidelines as Topic KW - Forecasting KW - Pharmacokinetics KW - Drug Interactions KW - United States Food and Drug Administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67325213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Predicting+drug-drug+interactions%3A+an+FDA+perspective.&rft.au=Zhang%2C+Lei%3BZhang%2C+Yuanchao+Derek%3BZhao%2C+Ping%3BHuang%2C+Shiew-Mei&rft.aulast=Zhang&rft.aufirst=Lei&rft.date=2009-06-01&rft.volume=11&rft.issue=2&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-009-9106-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-12 N1 - Date created - 2009-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Clin Pharmacol. 1999 Nov;48(5):716-27 [10594474] J Clin Pharmacol. 2009 Mar;49(3):351-9 [19246732] Pharm Res. 2000 Mar;17(3):336-43 [10801223] Biochemistry. 2000 May 23;39(20):5929-39 [10821664] Drug Metab Dispos. 2000 Aug;28(8):895-8 [10901697] Clin Pharmacol Ther. 2001 Nov;70(5):415-24 [11719727] AAPS PharmSci. 2002;4(4):E25 [12645997] Curr Drug Metab. 2003 Oct;4(5):423-59 [14529374] Eur J Pharm Sci. 2003 Oct;20(2):223-32 [14550889] Br J Clin Pharmacol. 2004 Apr;57(4):473-86 [15025746] Clin Pharmacol Ther. 2004 Aug;76(2):167-77 [15289793] Annu Rev Pharmacol Toxicol. 1998;38:461-99 [9597163] Pharm Res. 2005 Jan;22(1):11-23 [15771225] Pharmacogenet Genomics. 2005 Oct;15(10):677-85 [16141793] J Pharmacol Exp Ther. 2006 Jan;316(1):336-48 [16192315] Gastroenterology. 2006 May;130(6):1793-806 [16697742] Drug Metab Dispos. 2006 Jul;34(7):1208-19 [16611859] Am J Health Syst Pharm. 2006 Nov 15;63(22):2211-7 [17090741] J Pharmacol Exp Ther. 2007 Jan;320(1):72-80 [17041008] Clin Pharmacol Ther. 2007 Feb;81(2):298-304 [17259955] Nat Rev Drug Discov. 2007 Feb;6(2):140-8 [17268485] Theor Biol Med Model. 2007;4:13 [17386084] J Clin Invest. 2007 May;117(5):1422-31 [17476361] Chem Biol Interact. 2007 May 20;168(1):51-65 [17239835] Curr Drug Metab. 2007 Jun;8(5):449-62 [17584016] Clin Liver Dis. 2007 Aug;11(3):563-75, vi-vii [17723920] Clin Pharmacol Ther. 2008 Feb;83(2):273-80 [17609683] Expert Opin Drug Metab Toxicol. 2008 Feb;4(2):151-64 [18330044] Br J Clin Pharmacol. 2008 May;65(5):680-92 [18279465] Drug Metab Dispos. 2008 Jun;36(6):1126-34 [18356267] J Clin Pharmacol. 2008 Jun;48(6):662-70 [18378963] Pharm Res. 2008 Aug;25(8):1891-901 [18483837] Xenobiotica. 2008 Jul;38(7-8):709-24 [18668428] Clin Pharmacol Ther. 2008 Sep;84(3):287-94 [18714314] Drug Metab Dispos. 2008 Sep;36(9):1971-4 [18519654] Curr Drug Metab. 2008 Nov;9(9):940-51 [18991591] Eur J Pharm Sci. 2009 Feb 15;36(2-3):175-91 [19013237] Clin Pharmacol Ther. 2009 Feb;85(2):173-81 [18987624] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42 [10667461] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1208/s12248-009-9106-3 ER - TY - JOUR T1 - Evaluation of the filtration performance of 21 N95 filtering face piece respirators after prolonged storage. AN - 67303240; 19188003 AB - Organizations are stockpiling respirators to prepare for an influenza pandemic. To understand better the effects of prolonged storage, this investigation evaluated the filtration efficiency of 21 different models of National Institute for Occupational Safety and Health (NIOSH)-certified disposable N95 filtering face piece respirators. These respirators had been stored in their original packaging for a period of at least 6 years in research laboratories and dry warehouse facilities, ranging in temperature between 15 degrees C and 32 degrees C and relative humidity between 20% and 80%. Filter penetration was measured using an abbreviated version of the NIOSH respirator certification test incorporating a polydisperse sodium chloride aerosol at 85 L/min. Of the 21 respirator models tested, 19 models had both average penetration results of less than 5%. Mean initial penetration values ranged from 0.39% to 5.83%, whereas mean maximum penetration values ranged from 0.95% to 5.83%. There did not appear to be any correlation between the length of storage and failure to pass the filtration test. Results indicate that most N95 filtering face piece respirators stored for up to 10 years at warehouse conditions will likely have expected levels of filtration performance and that the degree of filtration efficiency degradation is likely model specific. JF - American journal of infection control AU - Viscusi, Dennis J AU - Bergman, Mike AU - Sinkule, Edward AU - Shaffer, Ronald E AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health/CDC, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 381 EP - 386 VL - 37 IS - 5 KW - Aerosols KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Index Medicus KW - United States KW - Filtration -- standards KW - Particle Size KW - Humans KW - Filtration -- instrumentation KW - National Institute for Occupational Safety and Health (U.S.) -- standards KW - Time Factors KW - Inhalation Exposure -- prevention & control KW - Equipment Failure Analysis KW - Respiratory Protective Devices -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67303240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+infection+control&rft.atitle=Evaluation+of+the+filtration+performance+of+21+N95+filtering+face+piece+respirators+after+prolonged+storage.&rft.au=Viscusi%2C+Dennis+J%3BBergman%2C+Mike%3BSinkule%2C+Edward%3BShaffer%2C+Ronald+E&rft.aulast=Viscusi&rft.aufirst=Dennis&rft.date=2009-06-01&rft.volume=37&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=American+journal+of+infection+control&rft.issn=1527-3296&rft_id=info:doi/10.1016%2Fj.ajic.2008.09.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-01 N1 - Date created - 2009-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ajic.2008.09.021 ER - TY - JOUR T1 - Antiinflammatory and antinociceptive activities of gossypin and procumbentin--cyclooxygenase-2 (COX-2) inhibition studies. AN - 67288713; 19107863 AB - In the present study the antiinflammatory and antinociceptive activities of a few selected flavonoids were investigated. Procumbentin, gossypin, chrysin and methylhespiridin were studied for antiinflammatory and antinociceptive activities using in vitro enzymatic assays and in animal models utilizing acetic acid-induced writhing in mice and hind paw edema in rats. In vitro studies were performed using TMPD (NNN'N'-tetramethyl-p-phenylene diamine) and oxygraphic methods for COX-1 (cyclooxygenase-1), COX-2, 5-LOX (5-lipoxygenase) and 15-LOX. Gossypin and procumbentin showed COX-2 inhibitory activity and exhibited IC(50) (COX-2/COX-1) ratios of 0.14 and 0.11, respectively. None of the flavonoids tested in this study showed LOX inhibitory activity. Four groups were studied for each test compound following intraperitoneal (i.p.) administration of doses of 10, 30 and 100 mg/kg. Antiinflammatory activity was measured by the carrageenin-induced rat hind paw edema model and antinociceptive activity by acetic acid-induced writhing. Procumbentin and gossypin showed antinociceptive activity at the 100 mg/kg dose. Gossypin showed antiinflammatory activity at doses of 10, 30, 100 mg/kg. Procumbentin and gossypin exhibited COX-2 inhibitory activity when tested by in vitro methods. Procumbentin and gossypin showed antinociceptive, and gossypin showed antiinflammatory, activities. (c) 2008 John Wiley & Sons, Ltd. JF - Phytotherapy research : PTR AU - Mada, Sripal Reddy AU - Metukuri, Mallikarjuna Reddy AU - Burugula, Laxminarayana AU - Reddanna, Pallu AU - Krishna, Devarakonda Rama AD - Drug Metabolism and Clinical Pharmacokinetics Division, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AP, India. sripal.mada@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 878 EP - 884 VL - 23 IS - 6 KW - Analgesics KW - 0 KW - Anti-Inflammatory Agents KW - Cyclooxygenase 2 Inhibitors KW - Flavonoids KW - Lipoxygenase Inhibitors KW - procumbentin KW - gossypin KW - A3Q367XWX9 KW - Index Medicus KW - Rats KW - Molecular Structure KW - Animals KW - Lipoxygenase Inhibitors -- pharmacology KW - Rats, Wistar KW - Pain Measurement KW - Mice KW - Inhibitory Concentration 50 KW - Male KW - Cyclooxygenase 2 Inhibitors -- pharmacology KW - Analgesics -- pharmacology KW - Flavonoids -- pharmacology KW - Anti-Inflammatory Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67288713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Phytotherapy+research+%3A+PTR&rft.atitle=Antiinflammatory+and+antinociceptive+activities+of+gossypin+and+procumbentin--cyclooxygenase-2+%28COX-2%29+inhibition+studies.&rft.au=Mada%2C+Sripal+Reddy%3BMetukuri%2C+Mallikarjuna+Reddy%3BBurugula%2C+Laxminarayana%3BReddanna%2C+Pallu%3BKrishna%2C+Devarakonda+Rama&rft.aulast=Mada&rft.aufirst=Sripal&rft.date=2009-06-01&rft.volume=23&rft.issue=6&rft.spage=878&rft.isbn=&rft.btitle=&rft.title=Phytotherapy+research+%3A+PTR&rft.issn=1099-1573&rft_id=info:doi/10.1002%2Fptr.2727 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-17 N1 - Date created - 2009-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ptr.2727 ER - TY - JOUR T1 - Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. AN - 67283963; 18942116 AB - Altered expression of microRNAs (miRNAs) has been reported in diverse human cancers; however, the down-regulation or up-regulation of any particular miRNAs in cancer is not sufficient to address the role of these changes in carcinogenesis. In this study, using the rat model of liver carcinogenesis induced by a methyl-deficient diet, which is relevant to the hepatocarcinogenesis in humans associated with viral hepatitis C and B infections, alcohol exposure and metabolic liver diseases, we showed that the development of hepatocellular carcinoma (HCC) is characterized by prominent early changes in expression of miRNA genes, specifically by inhibition of expression of microRNAs miR-34a, miR-127, miR-200b, and miR-16a involved in the regulation of apoptosis, cell proliferation, cell-to-cell connection, and epithelial-mesenchymal transition. The mechanistic link between these alterations in miRNAs expression and the development of HCC was confirmed by the corresponding changes in the levels of E2F3, NOTCH1, BCL6, ZFHX1B, and BCL2 proteins targeted by these miRNAs. The significance of miRNAs expression dysregulation in respect to hepatocarcinogenesis was confirmed by the persistence of these miRNAs alterations in the livers of methyl-deficient rats re-fed a methyl-adequate diet. Altogether, the early occurrence of alterations in miRNAs expression and their persistence during the entire process of hepatocarcinogenesis indicate that the dysregulation of microRNAs expression may be an important contributing factor in the development of HCC. JF - Molecular carcinogenesis AU - Tryndyak, Volodymyr P AU - Ross, Sharon A AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 479 EP - 487 VL - 48 IS - 6 KW - MIRN34 microRNA, rat KW - 0 KW - MicroRNAs KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Blotting, Western KW - Apoptosis KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Liver Neoplasms, Experimental -- genetics KW - Liver Neoplasms, Experimental -- pathology KW - Liver Neoplasms, Experimental -- etiology KW - Down-Regulation KW - MicroRNAs -- genetics KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67283963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Down-regulation+of+the+microRNAs+miR-34a%2C+miR-127%2C+and+miR-200b+in+rat+liver+during+hepatocarcinogenesis+induced+by+a+methyl-deficient+diet.&rft.au=Tryndyak%2C+Volodymyr+P%3BRoss%2C+Sharon+A%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Tryndyak&rft.aufirst=Volodymyr&rft.date=2009-06-01&rft.volume=48&rft.issue=6&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.20484 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-12 N1 - Date created - 2009-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20484 ER - TY - JOUR T1 - A prospective study of meat, cooking methods, meat mutagens, heme iron, and lung cancer risks. AN - 67279102; 19369370 AB - Red and processed meat consumption may play a role in lung cancer pathogenesis because of these meats' fat and carcinogen content. We prospectively investigated whether meat type, cooking method, doneness level, and intake of specific meat mutagens and heme iron are associated with lung carcinoma. Men (n = 278,380) and women (n = 189,596) from the National Institutes of Health-AARP Diet and Health Study with no history of cancer at baseline were monitored for 8 y. Diet was assessed with a 124-item food-frequency questionnaire. A meat-cooking module was used to estimate the intake of individual heterocyclic amines, benzo(a)pyrene, and heme iron. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% CIs. In a comparison of quintiles 5 with 1 (Q5vsQ1), a high intake of red meat was associated with an increased risk of lung carcinoma in both men (HR(Q5vsQ1): 1.22; 95% CI: 1.09, 1.38; P for trend = 0.005) and women (HR(Q5vsQ1): 1.13; 95% CI: 0.97, 1.32; P for trend = 0.05). A high intake of processed meat increased the risk only in men (HR(Q5vsQ1): 1.23; 95% CI: 1.10, 1.37; P for trend = 0.003). In an analysis stratified by smoking status, we observed a tendency for an increased risk with red meat intake in never smoking men and women; however, the risks were not statistically significant. In a comparison of tertiles 3 and 1 (T3vsT1), the risk of lung carcinoma was associated with intake of well-/very-well-done meat (HR(T3vsT1): 1.20; 95% CI: 1.07, 1.35; P for trend = 0.002) and the intake of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (HR(Q5vsQ1): 1.20; 95% CI: 1.04, 1.38; P for trend = 0.04) in men. Heme iron intake increased the risk of lung carcinoma in both men (HR(Q5vsQ1): 1.25; 95% CI: 1.07, 1.45; P for trend = 0.02) and women (HR(Q5vsQ1): 1.18; 95% CI: 0.99, 1.42; P for trend = 0.002). We observed a moderate association between meat consumption and lung carcinoma, which might be explained by heme iron intake, high-temperature cooking, and associated mutagens. JF - The American journal of clinical nutrition AU - Tasevska, Natasa AU - Sinha, Rashmi AU - Kipnis, Victor AU - Subar, Amy F AU - Leitzmann, Michael F AU - Hollenbeck, Albert R AU - Caporaso, Neil E AU - Schatzkin, Arthur AU - Cross, Amanda J AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7242, USA. tasevskan@mail.nih.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 1884 EP - 1894 VL - 89 IS - 6 KW - Amines KW - 0 KW - Carcinogens KW - Heterocyclic Compounds KW - Mutagens KW - Trace Elements KW - Iron KW - E1UOL152H7 KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Carcinoma -- etiology KW - Sex Factors KW - Risk Factors KW - Humans KW - Middle Aged KW - Heterocyclic Compounds -- adverse effects KW - Diet KW - Male KW - Female KW - Amines -- adverse effects KW - Proportional Hazards Models KW - Meat KW - Lung Neoplasms -- etiology KW - Iron -- administration & dosage KW - Iron -- pharmacology KW - Cooking KW - Trace Elements -- administration & dosage KW - Trace Elements -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67279102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=A+prospective+study+of+meat%2C+cooking+methods%2C+meat+mutagens%2C+heme+iron%2C+and+lung+cancer+risks.&rft.au=Tasevska%2C+Natasa%3BSinha%2C+Rashmi%3BKipnis%2C+Victor%3BSubar%2C+Amy+F%3BLeitzmann%2C+Michael+F%3BHollenbeck%2C+Albert+R%3BCaporaso%2C+Neil+E%3BSchatzkin%2C+Arthur%3BCross%2C+Amanda+J&rft.aulast=Tasevska&rft.aufirst=Natasa&rft.date=2009-06-01&rft.volume=89&rft.issue=6&rft.spage=1884&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=1938-3207&rft_id=info:doi/10.3945%2Fajcn.2008.27272 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-12 N1 - Date created - 2009-05-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Cancer Prev. 1997 Dec;6(6):540-9 [9496456] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Food Chem Toxicol. 1998 Apr;36(4):289-97 [9651045] Cancer Causes Control. 1998 Dec;9(6):621-30 [10189048] Mutat Res. 1999 Jul 15;443(1-2):139-47 [10415437] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):483-90 [15734976] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Lung Cancer. 2005 Apr;48(1):1-9 [15777966] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Food Addit Contam. 2007 Apr;24(4):429-37 [17454117] Cancer Lett. 2007 Jul 8;252(1):115-22 [17240050] Free Radic Biol Med. 2007 Oct 1;43(7):1040-7 [17761300] PLoS Med. 2007 Dec;4(12):e325 [18076279] Lung Cancer. 2008 Sep;61(3):283-91 [18295929] Nutr Cancer. 1999;35(1):34-43 [10624704] Eur J Clin Nutr. 2000 Apr;54(4):281-7 [10745278] Cancer Causes Control. 2000 May;11(5):419-31 [10877335] Cancer Res. 2000 Jul 15;60(14):3753-6 [10919646] Carcinogenesis. 2001 Jan;22(1):199-202 [11159760] Food Chem Toxicol. 2001 May;39(5):423-36 [11313108] Lung Cancer. 2001 Oct;34(1):37-46 [11557111] Am J Epidemiol. 2001 Dec 15;154(12):1089-99 [11744511] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Jpn J Cancer Res. 2001 Dec;92(12):1259-69 [11749690] Lung Cancer. 2002 Jan;35(1):43-51 [11750712] Int J Cancer. 2002 Aug 20;100(6):706-13 [12209611] Nutr Cancer. 2002;42(1):18-24 [12235646] Lung Cancer. 2002 Oct;38(1):1-7 [12367786] Am J Epidemiol. 2002 Nov 1;156(9):813-23 [12396999] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] Mutat Res. 2003 Dec 10;533(1-2):153-71 [14643418] Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):293-8 [14973110] Asian Pac J Cancer Prev. 2004 Jan-Mar;5(1):58-65 [15075007] Environ Mol Mutagen. 2004;44(1):44-55 [15199546] Mutat Res. 1975 Dec;31(6):347-64 [768755] J Toxicol Environ Health. 1977 Jul;2(6):1267-77 [328917] Stat Med. 1989 May;8(5):551-61 [2657958] Mutat Res. 1991 Mar-Apr;259(3-4):399-410 [2017219] Eur J Cancer. 1992;28(2-3):495-501 [1591072] Food Chem Toxicol. 1993 Sep;31(9):655-75 [8406243] Cancer Res. 1995 Oct 15;55(20):4516-9 [7553619] Biochem Biophys Res Commun. 1996 Mar 27;220(3):1024-7 [8607785] Lung Cancer. 1996 Mar;14 Suppl 1:S63-74 [8785668] Lung Cancer. 1996 Jun;14(2-3):195-205 [8794403] Br J Nutr. 1997 Jun;77(6):833-51 [9227182] Cancer Causes Control. 1997 Nov;8(6):883-93 [9427431] Semin Hematol. 1998 Jan;35(1):5-12 [9460805] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3945/ajcn.2008.27272 ER - TY - JOUR T1 - Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays. AN - 67263239; 19336498 AB - With the advent of new technologies (e.g., genomics, automated analyses, and in vivo monitoring), new regulations (e.g., the reduction of animal tests by the European REACH), and new approaches to toxicology (e.g., Toxicity Testing in the 21st Century, National Research Council), the field of regulatory genetic toxicology is undergoing a serious re-examination. Within this context, Toxicological Sciences has published a series of articles in its Forum Section on the theme, "Genetic Toxicity Assessment: Employing the Best Science for Human Safety Evaluation" (beginning with Goodman et al.). As a contribution to the Forum discussions, we present current methods for evaluating mutagenic/genotoxic risk using standard genotoxicity test batteries, and suggest ways to address and incorporate new technologies. We recognize that the occurrence of positive results in relation to cancer prediction has led to criticism of in vitro mammalian cell genetic toxicity assays. We address criticism of test results related to weak positives, associated only with considerable toxicity, only seen at high concentrations, not accompanied by positive results in the other tests of standard test batteries, and/or not correlating well with rodent carcinogenicity tests. We suggest that the problems pointed out by others with these assays already have been resolved, to a large extent, by international groups working to update assay protocols, and by changes in data interpretation at regulatory agencies. New guidances at the U.S. Environmental Protection Agency and the U.S. Food and Drug Administration improve data evaluation and help refocus risk assessment. We discuss the results of international groups working together to integrate new technologies and evaluate new tests, including human monitoring. We suggest that strategies for identifying human health risks should naturally change to integrate new technologies; however, changes should be made only when justified by strong scientific evidence of improvement in the risk assessment paradigm. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Elespuru, Rosalie K AU - Agarwal, Rajiv AU - Atrakchi, Aisar H AU - Bigger, C Anita H AU - Heflich, Robert H AU - Jagannath, Devaraya R AU - Levy, Dan D AU - Moore, Martha M AU - Ouyang, Yanli AU - Robison, Timothy W AU - Sotomayor, Rene E AU - Cimino, Michael C AU - Dearfield, Kerry L AD - Office of Science & Engineering Laboratories, U.S. Food and Drug Administration, Center for Devices and Radiological Health, White Oak, Silver Spring, Maryland 20993, USA. rosalie.elespuru@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 172 EP - 179 VL - 109 IS - 2 KW - Index Medicus KW - Rats KW - Animals KW - Mammals KW - International Cooperation KW - Cells, Cultured KW - Humans KW - Rodentia KW - False Positive Reactions KW - Mutagenicity Tests -- methods KW - Mutagenicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67263239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Current+and+future+application+of+genetic+toxicity+assays%3A+the+role+and+value+of+in+vitro+mammalian+assays.&rft.au=Elespuru%2C+Rosalie+K%3BAgarwal%2C+Rajiv%3BAtrakchi%2C+Aisar+H%3BBigger%2C+C+Anita+H%3BHeflich%2C+Robert+H%3BJagannath%2C+Devaraya+R%3BLevy%2C+Dan+D%3BMoore%2C+Martha+M%3BOuyang%2C+Yanli%3BRobison%2C+Timothy+W%3BSotomayor%2C+Rene+E%3BCimino%2C+Michael+C%3BDearfield%2C+Kerry+L&rft.aulast=Elespuru&rft.aufirst=Rosalie&rft.date=2009-06-01&rft.volume=109&rft.issue=2&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfp067 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-03 N1 - Date created - 2009-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfp067 ER - TY - JOUR T1 - Cumulative exposure estimates for polychlorinated biphenyls using a job-exposure matrix. AN - 67254595; 19394668 AB - PCB exposure has been associated with increased risk for cancer, neurological disease, and for birth defects in children exposed in utero. Because of the long half-lives of PCB congeners, they remain a public health problem in the United States 30 years after being banned. Workers (n=3569) at an Indiana capacitor manufacturing plant were exposed to polychlorinated biphenyls (PCBs) from 1957 to 1977. The purpose of this work was to develop a period-specific job-exposure matrix (JEM) for a follow-up epidemiologic study investigating the increased risks for cancer previously observed in the cohort. We used eight exposure determinants to estimate PCB exposures systematically. Work history, job description, capacitor production factors, PCB usage trends, and air sample data were used to develop the JEM in four steps: (1) all job titles (n=884) were assessed for exposure determinants, (2) jobs with similar exposure determinants were grouped, (3) for each job exposure category, exposure intensity (high-medium-low-background) and frequency (continuous-intermittent) were qualitatively rated separately for inhalation and dermal exposure, and (4) for each job exposure category, the product of intensity (based on air sampling data) and frequency (fraction of day exposed) was calculated. The JEM was then modified for two eras of different PCB exposure conditions. The resulting JEM consists of inhalation and dermal exposure values for 19 job exposure categories. The JEM showed an exposure-response trend associated with increased brain cancer mortality in the epidemiologic study. JF - Chemosphere AU - Hopf, Nancy Brenna AU - Waters, Martha A AU - Ruder, Avima M AD - National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Cincinnati, OH, USA. NancyBHopf@gmail.com Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 185 EP - 193 VL - 76 IS - 2 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Inhalation KW - Brain Neoplasms -- mortality KW - Humans KW - Cohort Studies KW - Job Description KW - Electricity KW - Brain Neoplasms -- chemically induced KW - Polychlorinated Biphenyls -- toxicity KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67254595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Cumulative+exposure+estimates+for+polychlorinated+biphenyls+using+a+job-exposure+matrix.&rft.au=Hopf%2C+Nancy+Brenna%3BWaters%2C+Martha+A%3BRuder%2C+Avima+M&rft.aulast=Hopf&rft.aufirst=Nancy&rft.date=2009-06-01&rft.volume=76&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2009.03.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.chemosphere.2009.03.058 ER - TY - JOUR T1 - Radiation terrorism: what society needs from the radiobiology-radiation protection and radiation oncology communities. AN - 67254450; 19454803 AB - Society's and individuals' concerns about the adverse effects from radiation are logically amplified many times when radiological terrorism is considered. The spectrum of events include industrial sabotage, the use of an explosive or non-explosive radiological dispersal device, the placement of a radiological exposure device in a public facility and the use of an improvised nuclear device. The consequences of an event relate to the physical and medical damage of the event itself, the financial impact, and the acute and long-term medical consequences, including fear of radiation-induced cancer. The magnitude of a state-sponsored nuclear event is so great that limited detailed response planning had been done in the past, as compared to the work now ongoing. Planning is done on the basis of scenario modelling. Medical response planning includes medical triage, distribution of victims to care by experienced physicians, developing medical countermeasures to mitigate or treat radiation injury, counselling and appropriately following exposed or potentially exposed people, and helping the local community develop confidence in their own response plan. Optimal response must be based on the best available science. This requires scientists who can define, prioritise and address the gaps in knowledge with the range of expertise from basic physics to biology to translational research to systems expertise to response planning to healthcare policy to communications. Not only are there unique needs and career opportunities, but there is also the opportunity for individuals to serve their communities and country with education regarding radiation effects and by formulating scientifically based government policy. JF - Journal of radiological protection : official journal of the Society for Radiological Protection AU - Coleman, C Norman AU - Parker, Gerald W AD - Office of Preparedness and Emergency Response, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC, USA. Y1 - 2009/06// PY - 2009 DA - June 2009 SP - A159 EP - A169 VL - 29 IS - 2A SN - 0952-4746, 0952-4746 KW - Index Medicus KW - Triage KW - Humans KW - Communication KW - Algorithms KW - Residence Characteristics KW - Risk Assessment KW - Radiation Oncology KW - Radiation Protection KW - Radiobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67254450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+radiological+protection+%3A+official+journal+of+the+Society+for+Radiological+Protection&rft.atitle=Radiation+terrorism%3A+what+society+needs+from+the+radiobiology-radiation+protection+and+radiation+oncology+communities.&rft.au=Coleman%2C+C+Norman%3BParker%2C+Gerald+W&rft.aulast=Coleman&rft.aufirst=C&rft.date=2009-06-01&rft.volume=29&rft.issue=2A&rft.spage=A159&rft.isbn=&rft.btitle=&rft.title=Journal+of+radiological+protection+%3A+official+journal+of+the+Society+for+Radiological+Protection&rft.issn=09524746&rft_id=info:doi/10.1088%2F0952-4746%2F29%2F2A%2FS11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-25 N1 - Date created - 2009-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1088/0952-4746/29/2A/S11 ER - TY - JOUR T1 - Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part C: use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities. AN - 67220008; 19422100 AB - This report describes an in silico methodology to predict off-target pharmacologic activities and plausible mechanisms of action (MOAs) associated with serious and unexpected hepatobiliary and urinary tract adverse effects in human patients. The investigation used a database of 8,316,673 adverse event (AE) reports observed after drugs had been marketed and AEs noted in the published literature that were linked to 2124 chemical structures and 1851 approved clinical indications. The Integrity database of drug patent and literature studies was used to find pharmacologic targets and proposed clinical indications. BioEpisteme QSAR software was used to predict possible molecular targets of drug molecules and Derek for Windows expert system software to predict chemical structural alerts and plausible MOAs for the AEs. AEs were clustered into five types of liver injury: liver enzyme disorders, cytotoxic injury, cholestasis and jaundice, bile duct disorders, and gall bladder disorders, and six types of urinary tract injury: acute renal disorders, nephropathies, bladder disorders, kidney function tests, blood in urine, and urolithiasis. Results showed that drug-related AEs were highly correlated with: (1) known drug class warnings, (2) predicted off-target activities of the drugs, and (3) a specific subset of clinical indications for which the drug may or may not have been prescribed. JF - Regulatory toxicology and pharmacology : RTP AU - Matthews, Edwin J AU - Kruhlak, Naomi L AU - Benz, R Daniel AU - Aragonés Sabaté, David AU - Marchant, Carol A AU - Contrera, Joseph F AD - US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff, Silver Spring, MD 20993-0002, USA. Edwin.Matthews@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 43 EP - 65 VL - 54 IS - 1 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - United States KW - Pharmaceutical Preparations -- administration & dosage KW - United States Food and Drug Administration KW - Quantitative Structure-Activity Relationship KW - Endpoint Determination KW - Pharmaceutical Preparations -- chemistry KW - Humans KW - Product Surveillance, Postmarketing KW - Databases, Factual KW - Drug Labeling KW - Chemical and Drug Induced Liver Injury -- etiology KW - Urologic Diseases -- chemically induced KW - Drug-Related Side Effects and Adverse Reactions KW - Biliary Tract Diseases -- chemically induced KW - Adverse Drug Reaction Reporting Systems -- organization & administration KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67220008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Identification+of+structure-activity+relationships+for+adverse+effects+of+pharmaceuticals+in+humans%3A+Part+C%3A+use+of+QSAR+and+an+expert+system+for+the+estimation+of+the+mechanism+of+action+of+drug-induced+hepatobiliary+and+urinary+tract+toxicities.&rft.au=Matthews%2C+Edwin+J%3BKruhlak%2C+Naomi+L%3BBenz%2C+R+Daniel%3BAragon%C3%A9s+Sabat%C3%A9%2C+David%3BMarchant%2C+Carol+A%3BContrera%2C+Joseph+F&rft.aulast=Matthews&rft.aufirst=Edwin&rft.date=2009-06-01&rft.volume=54&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-24 N1 - Date created - 2009-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Utilization of substance abuse treatment services under Medicare, 2001-2002. AN - 67189466; 18835680 AB - In 2006, the Medicare program covered 37 million elderly persons and 7 million persons younger than 65 years, but little is known about substance abuse (SA) service utilization. Using the 5% Sample of Medicare claims data, the study examines individuals who used SA detoxification ("detox") and/or rehabilitation ("rehab") services under Medicare in 2001 and 2002. SA claimants less than 65 years of age (disabled) were compared to claimants more than 65 years of age (elderly). The disabled were more likely to have a co-occurring mental disorder than elderly claimants (50% vs. 14%) and more likely to have serious mental illness (21% vs. 2.3%). Disabled claimants were more than three times as likely to receive any detox service as elderly claimants (17% vs. 6%). The rate of claimants receiving rehab services within 30 days of detox is about one third for disabled claimants and one quarter for elderly claimants. JF - Journal of substance abuse treatment AU - Vandivort, Rita AU - Teich, Judith L AU - Cowell, Alexander J AU - Chen, Hong AD - Substance Abuse and Mental Health Services Administration, Center for Mental Health Services, Rockville, MD, USA. rita.vandivort@samhsa.hhs.gov Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 414 EP - 419 VL - 36 IS - 4 KW - Index Medicus KW - United States KW - Age Factors KW - Substance Withdrawal Syndrome -- rehabilitation KW - Medicare -- statistics & numerical data KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Databases, Factual KW - Aged KW - Middle Aged KW - Mental Disorders -- complications KW - Male KW - Female KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- rehabilitation KW - Substance Abuse Treatment Centers -- utilization KW - Disabled Persons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67189466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Utilization+of+substance+abuse+treatment+services+under+Medicare%2C+2001-2002.&rft.au=Vandivort%2C+Rita%3BTeich%2C+Judith+L%3BCowell%2C+Alexander+J%3BChen%2C+Hong&rft.aulast=Vandivort&rft.aufirst=Rita&rft.date=2009-06-01&rft.volume=36&rft.issue=4&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=1873-6483&rft_id=info:doi/10.1016%2Fj.jsat.2008.08.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-10 N1 - Date created - 2009-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jsat.2008.08.007 ER - TY - JOUR T1 - Injury and adaptive mechanisms in skeletal muscle. AN - 67082066; 18768331 AB - Work-related musculoskeletal disorders (MSD) are a major concern in the United States. Overexertion and repetitive motion injuries dominate reporting of lost-time MSD incidents. Over the past three decades, there has been much study on contraction-induced skeletal muscle injury. The effect of the biomechanical loading signature that includes velocity, range of motion, the number of repetitions, force, work-rest cycle, and exposure duration has been studied. More recently, the effect of aging on muscle injury susceptibility and regeneration has been studied. This review will focus on contraction-induced skeletal muscle injury, the effects of repetitions, range of motion, work-rest cycles, and aging on injury susceptibility and regenerative and adaptive pathways. The different physiological phenomena responsive to overt muscle injury versus adaptation will be distinguished. The inherent capability of skeletal muscle to adapt to mechanical loading, given the appropriate exposure signature will also be discussed. Finally, we will submit that repeated high-intensity mechanical loading is a desirable means to attenuate the effects of sarcopenia, and may be the most effective and appealing mode of physical activity to counteract the effects often observed with musculo-skeletal dysfunction in the workplace. JF - Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology AU - Cutlip, Robert G AU - Baker, Brent A AU - Hollander, Melinda AU - Ensey, James AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Don Nehlen Drive, M/S 2027, Morgantown, WV 26506, USA. RGC8@CDC.GOV Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 358 EP - 372 VL - 19 IS - 3 KW - Index Medicus KW - Animals KW - Humans KW - Adaptation, Physiological KW - Muscle, Skeletal -- injuries KW - Occupational Diseases -- physiopathology KW - Muscle, Skeletal -- physiopathology KW - Muscular Diseases -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67082066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+electromyography+and+kinesiology+%3A+official+journal+of+the+International+Society+of+Electrophysiological+Kinesiology&rft.atitle=Injury+and+adaptive+mechanisms+in+skeletal+muscle.&rft.au=Cutlip%2C+Robert+G%3BBaker%2C+Brent+A%3BHollander%2C+Melinda%3BEnsey%2C+James&rft.aulast=Cutlip&rft.aufirst=Robert&rft.date=2009-06-01&rft.volume=19&rft.issue=3&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=Journal+of+electromyography+and+kinesiology+%3A+official+journal+of+the+International+Society+of+Electrophysiological+Kinesiology&rft.issn=1873-5711&rft_id=info:doi/10.1016%2Fj.jelekin.2008.06.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-02 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jelekin.2008.06.007 ER - TY - BOOK T1 - Healthcare and Social Assistance Advancing Priorities through Research and Partnerships AN - 58832974; 2008-442376 AB - Most people think of the Healthcare and Social Assistance (HCSA) industry as providing clean, sterile and safe places to work. In reality, HCSA workers are exposed to many hazards that can affect their health and well-being. Their work exposes them to life threatening infections, such as SARS, HIV and hepatitis. They work with highly toxic cancer treating drugs and various chemical agents. They perform physically demanding tasks, such as lifting patients. In fact, this sector of the economy is highly hazardous and puts workers at a surprising risk for illness and injury. JF - United States National Institute for Occupational Safety and Health (NIOSH), Jun 2009, 2 pp. AU - National Institute for Occupational Safety and Health Y1 - 2009/06// PY - 2009 DA - June 2009 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Business and service sector - Personal and housekeeping services KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Business and service sector - Business operations, practices, and workplaces KW - Health conditions and policy - Diseases and disorders KW - Social conditions and policy - Public safety and security KW - Chemicals KW - Risk KW - Caregivers KW - Diseases KW - Workplaces KW - Working conditions KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58832974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Institute+for+Occupational+Safety+and+Health&rft.aulast=National+Institute+for+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2009-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Healthcare+and+Social+Assistance+Advancing+Priorities+through+Research+and+Partnerships&rft.title=Healthcare+and+Social+Assistance+Advancing+Priorities+through+Research+and+Partnerships&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2009-149/pdfs/2009-149.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-02-03 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2009 N1 - SuppNotes - NIOSH Publication No. 2009-149 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Intrinsically autoregressive spatiotemporal models with application to aggregated birth outcomes AN - 37166942; 3881828 JF - Journal of the American Statistical Association AU - Norton, Jonathan D AU - Niu, Xu-Feng AD - Food and Drug Administration, USA ; Florida State University Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 638 EP - 649 VL - 104 IS - 486 SN - 0162-1459, 0162-1459 KW - Economics KW - Birth KW - Deviance KW - Mapping KW - Diseases KW - Statistical methods KW - Identification KW - Hierarchy KW - Vector-autoregressive models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37166942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Intrinsically+autoregressive+spatiotemporal+models+with+application+to+aggregated+birth+outcomes&rft.au=Norton%2C+Jonathan+D%3BNiu%2C+Xu-Feng&rft.aulast=Norton&rft.aufirst=Jonathan&rft.date=2009-06-01&rft.volume=104&rft.issue=486&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2Fjasa.2009.003 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1635 11574; 13258 3864 8163 10739 12228 10919; 3519 6071 1542 11325; 3617 6220; 7675 3681; 5837 2360 2688 2449 10404 11936; 6190 6191; 12228 10919 DO - http://dx.doi.org/10.1198/jasa.2009.003 ER - TY - JOUR T1 - Bayesian analysis of cancer rates from SEER program using parametric and semiparametric jointpoint regression models AN - 37166341; 3881813 JF - Journal of the American Statistical Association AU - Ghosh, Pulak AU - Basu, Sanjib AU - Tiwari, Ram C AD - Georgia State University ; Northern Illinois University ; Food and Drug Administration, USA Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 439 EP - 452 VL - 104 IS - 486 SN - 0162-1459, 0162-1459 KW - Economics KW - Monte Carlo simulation KW - Causes of death KW - Mortality KW - Epidemiology KW - Regression analysis KW - U.S.A. KW - Statistical methods KW - Cancer KW - Markovian processes KW - Bayesian method UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37166341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Bayesian+analysis+of+cancer+rates+from+SEER+program+using+parametric+and+semiparametric+jointpoint+regression+models&rft.au=Ghosh%2C+Pulak%3BBasu%2C+Sanjib%3BTiwari%2C+Ram+C&rft.aulast=Ghosh&rft.aufirst=Pulak&rft.date=2009-06-01&rft.volume=104&rft.issue=486&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2Fjasa.2009.0038 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1512 3865 4025; 2091 3303; 8291 3409 6306; 4357 7894; 1939 3617 6220; 10739 12228 10919; 7747 12265 3865 4025 10214 12224 971 12228 10919; 8268 12265 3865 4025 10214 12224 971 12228 10919; 12228 10919; 433 293 14 DO - http://dx.doi.org/10.1198/jasa.2009.0038 ER - TY - JOUR T1 - Local Hospital Disaster Preparedness AN - 219235177 AB - Hospital senior leaders now actively support and participate in preparedness activities, hospital emergency operations plans are more comprehensive and better coordinated with community emergency plans and local hazards, and disaster training has become more rigorous, the report said. JF - The Journal of Nuclear Medicine AU - Anonymous Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 2 EP - 22N,23N CY - New York PB - Society of Nuclear Medicine VL - 50 IS - 6 SN - 01615505 KW - Physics KW - Hospitals KW - Health care industry KW - Emergency preparedness KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/219235177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Nuclear+Medicine&rft.atitle=Local+Hospital+Disaster+Preparedness&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-06-01&rft.volume=50&rft.issue=6&rft.spage=22N&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Department of Health & Human Services N1 - Copyright - Copyright Society of Nuclear Medicine Jun 2009 N1 - Last updated - 2012-02-25 N1 - CODEN - JNMEAQ ER - TY - JOUR T1 - Epileptic Spike Recognition in Electroencephalogram Using Deterministic Finite Automata AN - 216796510; 19408450 AB - This Paper presents an automated method of Epileptic Spike detection in Electroencephalogram (EEG) using Deterministic Finite Automata (DFA). It takes pre-recorded single channel EEG data file as input and finds the occurrences of Epileptic Spikes data in it. The EEG signal was recorded at 256 Hz in two minutes separate data files using the Visual Lab-M software (ADLink Technology Inc., Taiwan). It was preprocessed for removal of baseline shift and band pass filtered using an infinite impulse response (IIR) Butterworth filter. A system, whose functionality was modeled with DFA, was designed. The system was tested with 10 EEG signal data files. The recognition rate of Epileptic Spike as on average was 95.68%. This system does not require any human intrusion. Also it does not need any short of training. The result shows that the application of DFA can be useful in detection of different characteristics present in EEG signals. This approach could be extended to a continuous data processing system. [PUBLICATION ABSTRACT] JF - Journal of Medical Systems AU - Kumar Keshri, Anup AU - Kumar Sinha, Rakesh AU - Hatwal, Rajesh AU - Nand Das, Barda Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 173 EP - 9 CY - New York PB - Springer Science & Business Media VL - 33 IS - 3 SN - 0148-5598 KW - Medical Sciences--Computer Applications KW - Epilepsy KW - Medical technology KW - Electroencephalography KW - Rats KW - Brain -- physiopathology KW - Animals KW - Epilepsy -- physiopathology KW - Male KW - Signal Processing, Computer-Assisted -- instrumentation KW - Epilepsy -- diagnosis KW - Electroencephalography -- instrumentation KW - Image Interpretation, Computer-Assisted -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/216796510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomputing&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Systems&rft.atitle=Epileptic+Spike+Recognition+in+Electroencephalogram+Using+Deterministic+Finite+Automata&rft.au=Kumar+Keshri%2C+Anup%3BKumar+Sinha%2C+Rakesh%3BHatwal%2C+Rajesh%3BNand+Das%2C+Barda&rft.aulast=Kumar+Keshri&rft.aufirst=Anup&rft.date=2009-06-01&rft.volume=33&rft.issue=3&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Systems&rft.issn=01485598&rft_id=info:doi/10.1007%2Fs10916-008-9177-1 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2009 N1 - Document feature - References N1 - Last updated - 2014-07-26 DO - http://dx.doi.org/10.1007/s10916-008-9177-1 ER - TY - JOUR T1 - Detection of Live Salmonella sp. Cells in Produce by a TaqMan-Based Quantitative Reverse Transcriptase Real-Time PCR Targeting invA mRNA , AN - 21486448; 12509966 AB - Salmonella enterica contamination in foods is a significant concern for public health. When DNA detection methods are used for analysis of foods, one of the major concerns is false-positive results from the detection of dead cells. To circumvent this crucial issue, a TaqMan quantitative real-time RT-PCR (qRT-PCR) assay with an RNA internal control was developed. invA RNA standards were used to determine the detection limit of this assay as well as to determine invA mRNA levels in mid-exponential-, late-exponential-, and stationary-phase cells. This assay has a detection limit of 40 copies of invA mRNA per reaction. The levels of invA mRNA in mid-exponential-, late-exponential-, and stationary-phase S. enterica cells was approximately 1 copy per 3 CFU, 1 copy per CFU, and 4 copies per 103 CFU, respectively. Spinach, tomatoes, jalapeno peppers, and serrano peppers were artificially contaminated with four different Salmonella serovars at levels of 105 and less than 10 CFU. These foods were analyzed with qRT-PCR and with the FDA's Bacteriological Analytical Manual Salmonella culture method (W. A. Andrews and T. S. Hammack, in G. J. Jackson et al., ed., Bacteriological analytical manual online, http://www.cfsan.fda.gov/ebam/bam-5.html, 2007). Comparable results were obtained by both methods. Only live Salmonella cells could be detected by this qRT-PCR assay, thus avoiding the dangers of false-positive results from nonviable cells. False negatives (inhibition of the PCR) were also ruled out through the use of an RNA internal control. This assay allows for the fast and accurate detection of viable Salmonella spp. in spinach, tomatoes, and in both jalapeno and serrano peppers. JF - Applied and Environmental Microbiology AU - Gonzalez-Escalona, Narjol AU - Hammack, Thomas S AU - Russell, Mindi AU - Jacobson, Andrew P AU - De Jesus, Antonio J AU - Brown, Eric W AU - Lampel, Keith A AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, narjol.gonzalez-escalona@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 3714 EP - 3720 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 75 IS - 11 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Cell culture KW - Lycopersicon esculentum KW - Colony-forming cells KW - J 02400:Human Diseases KW - N 14810:Methods KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21486448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Detection+of+Live+Salmonella+sp.+Cells+in+Produce+by+a+TaqMan-Based+Quantitative+Reverse+Transcriptase+Real-Time+PCR+Targeting+invA+mRNA+%2C&rft.au=Gonzalez-Escalona%2C+Narjol%3BHammack%2C+Thomas+S%3BRussell%2C+Mindi%3BJacobson%2C+Andrew+P%3BDe+Jesus%2C+Antonio+J%3BBrown%2C+Eric+W%3BLampel%2C+Keith+A&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2009-06-01&rft.volume=75&rft.issue=11&rft.spage=3714&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02686-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Colony-forming cells; Lycopersicon esculentum DO - http://dx.doi.org/10.1128/AEM.02686-08 ER - TY - JOUR T1 - Analysis of Musculoskeletal Loadings in Lower Limbs During Stilts Walking in Occupational Activity AN - 21332188; 11772816 AB - Construction workers often use stilts to raise them to a higher level above ground to perform many tasks, such as taping and sanding on the ceiling or upper half of a wall. Some epidemiological studies indicated that the use of stilts may place workers at increased risk for knee injuries or may increase the likelihood of trips and falls. In the present study, we developed an inverse dynamic model of stilts walking to investigate the effects of this activity on the joint moments and musculoskeletal loadings in the lower limbs. The stilts-walk model was developed using the commercial musculoskeletal simulation software AnyBody (version 3.0, Anybody Technology, Aalborg, Denmark). Simulations were performed using data collected from tests of four subjects. All subjects walked without or with stilts through a 12-m straight path. The moments of the knee, hip, and ankle joints, as well as forces in major muscles or muscle groups in the lower limbs, for stilts walking were compared with those for normal walking. Our simulations showed that the use of stilts may potentially increase the peak joint moment in knee extension by approximately 20%; induce 15% reduction and slight reduction in the peak joint moments in ankle plantar flexion and hip extension, respectively. The model predictions on the muscle forces indicated that the use of stilts may potentially increase loadings in five of eight major muscle groups in the lower extremities. The most remarkable was the force in rectus femoris muscle, which was found to potentially increase by up to 1.79 times for the stilts walking compared to that for the normal walking. The proposed model would be useful for the engineers in their efforts to improve the stilts design to reduce musculoskeletal loadings and fall risk. JF - Annals of Biomedical Engineering AU - Wu, John Z AU - Chiou, Sharon S AU - Pan, Christopher S AD - National Institute for Occupational Safety and Health, NIOSH, 1095 Willowdale Road, Morgantown, WV, 26505, USA, jwu@cdc.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 1177 EP - 1189 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 37 IS - 6 SN - 0090-6964, 0090-6964 KW - Biotechnology and Bioengineering Abstracts KW - Muscle contraction KW - Data processing KW - Injuries KW - Muscles KW - Walking KW - plantar flexion KW - Knee KW - Joints KW - Models KW - Computer programs KW - Workers KW - software KW - Limbs KW - Ankle KW - Hip KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21332188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=Analysis+of+Musculoskeletal+Loadings+in+Lower+Limbs+During+Stilts+Walking+in+Occupational+Activity&rft.au=Wu%2C+John+Z%3BChiou%2C+Sharon+S%3BPan%2C+Christopher+S&rft.aulast=Wu&rft.aufirst=John&rft.date=2009-06-01&rft.volume=37&rft.issue=6&rft.spage=1177&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1007%2Fs10439-009-9674-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Walking; Muscles; Hip; Models; Limbs; Knee; Joints; Workers; Ankle; plantar flexion; Data processing; Computer programs; Muscle contraction; software; Injuries DO - http://dx.doi.org/10.1007/s10439-009-9674-5 ER - TY - JOUR T1 - Short-Term and Medium-Term Clinical Outcomes of Quinolone-Resistant Campylobacter Infection AN - 21294553; 11849232 AB - Background._Campylobacter species is a leading cause of bacterial gastroenteritis worldwide. Quinolone resistance has emerged as an increasing problem among persons with Campylobacter infection over the past decade, but the clinical consequences are unclear. Methods._A case-comparison study of patients infected with ciprofloxacin-resistant or ciprofloxacin-susceptible Campylobacter species was conducted in Wales during the period 2003-2004. Campylobacter isolates were classified as resistant or susceptible to dprofloxacin on the basis of standardized disk diffusion methods. Participants were interviewed by telephone at the time of illness, 3 months later, and 6 months later to compare disease severity, duration of illness, and medium-term clinical outcomes. Results._There was no difference between 145 persons with ciprofloxacin-resistant infection and 411 with ciprofloxacin-susceptible infection with regard to the severity or duration of acute illness. Mean duration of diarrhea was similar in patients with ciprofloxacin-resistant versus ciprofloxacin-susceptible infection (8.2 vs. 8.6 days; P = .57) and did not alter significantly after adjustment for potential covariates, including age, underlying disease, foreign travel, use of antldiarrheal medication, and use of antimicrobials in a multiple linear regression model. There was no difference between case patients and comparison patients in the frequency of reported symptoms or in general practitioner consultation rates at either the 3-month or the 6-month follow-up interview. Conclusions._In this study, there was no evidence of more-severe or prolonged illness in participants with quinolone-resistant Campylobacter infection, nor was there evidence of any adverse medium-term consequences. This suggests that the clinical significance of quinolone resistance in Campylobacter infection may have been overestimated. JF - Clinical Infectious Diseases AU - Evans, M R AU - Northey, G AU - Sarvotham, T S AU - Rigby, C J AU - Hopkins, AL AU - Thomas AD - Communicable Disease Surveillance Centre, National Public Health Service for Wales, Temple of Peace and Health, Cathays Park, Cardiff CF10 3NW, UK, meirion.evans@nphs.wales.nhs.uk Y1 - 2009/06/01/ PY - 2009 DA - 2009 Jun 01 SP - 1500 EP - 1506 VL - 48 IS - 11 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Travel KW - Age KW - Diarrhea KW - Quinolones KW - Regression analysis KW - Campylobacter KW - Diffusion KW - Infection KW - Gastroenteritis KW - Models KW - Antimicrobial agents KW - J 02400:Human Diseases KW - A 01350:Microbial Resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21294553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Short-Term+and+Medium-Term+Clinical+Outcomes+of+Quinolone-Resistant+Campylobacter+Infection&rft.au=Evans%2C+M+R%3BNorthey%2C+G%3BSarvotham%2C+T+S%3BRigby%2C+C+J%3BHopkins%2C+AL%3BThomas&rft.aulast=Evans&rft.aufirst=M&rft.date=2009-06-01&rft.volume=48&rft.issue=11&rft.spage=1500&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F598932 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Travel; Age; Diarrhea; Quinolones; Regression analysis; Diffusion; Gastroenteritis; Infection; Antimicrobial agents; Models; Campylobacter DO - http://dx.doi.org/10.1086/598932 ER - TY - JOUR T1 - A Nested Case-Control Study of Multiple Myeloma Risk and Uranium Exposure among Workers at the Oak Ridge Gaseous Diffusion Plant AN - 21198700; 11587760 AB - Yiin, J. H., Anderson, J. L., Daniels, R. D., Seel, E. A., Fleming, D. A., Waters, K. M. and Chen, P-H. A Nested Case-Control Study of Multiple Myeloma Risk and Uranium Exposure among Workers at the Oak Ridge Gaseous Diffusion Plant. Radiat. Res. 171, 637-645 (2009). JF - Radiation Research AU - Yiin, James H AU - Anderson, Jeri L AU - Daniels, Robert D AU - Seel, Evelyn A AU - Fleming, Donald A AU - Waters, Kathleen M AU - Chen, Pi-Hsueh AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226 Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 637 EP - 645 PB - Radiation Research Society VL - 171 IS - 6 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts; Immunology Abstracts KW - Multiple myeloma KW - Uranium KW - Diffusion KW - Occupational exposure KW - X 24390:Radioactive Materials KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21198700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=A+Nested+Case-Control+Study+of+Multiple+Myeloma+Risk+and+Uranium+Exposure+among+Workers+at+the+Oak+Ridge+Gaseous+Diffusion+Plant&rft.au=Yiin%2C+James+H%3BAnderson%2C+Jeri+L%3BDaniels%2C+Robert+D%3BSeel%2C+Evelyn+A%3BFleming%2C+Donald+A%3BWaters%2C+Kathleen+M%3BChen%2C+Pi-Hsueh&rft.aulast=Yiin&rft.aufirst=James&rft.date=2009-06-01&rft.volume=171&rft.issue=6&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1607.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Multiple myeloma; Uranium; Diffusion; Occupational exposure DO - http://dx.doi.org/10.1667/RR1607.1 ER - TY - JOUR T1 - Difference in the Lubrication Efficiency of Bovine and Vegetable-Derived Magnesium Stearate During Tabletting AN - 21132449; 11177160 AB - The purpose of this work was to evaluate and compare the functionality of bovine fatty acids-derived (MgSt-B) and vegetable fatty acids-derived (MgSt-V) magnesium stearate powders when used for the lubrication of granules prepared by high-shear (HSG) and fluid bed (FBG) wet granulation methods. The work included evaluation of tablet compression and ejection forces during tabletting and dissolution testing of the compressed tablets. Granules prepared by both granulation methods required significantly lower ejection force (p<0.01) when lubricated with the MgSt-V powder as compared to those lubricated with the MgSt-B powder. Granules prepared by the HSG method and lubricated with the MgSt-V powder also required significantly lower compression force (p<0.01) to produce tablets of similar weight and hardness as compared to those lubricated with the MgSt-B powder. The dissolution profiles were not affected by these differences and were the same for tablets prepared by same granulation method and lubricated with either magnesium stearate powder. The results indicate significant differences (p<0.01) between lubrication efficiency of the MgSt-B and the MgSt-V powders and emphasize the importance of functionality testing of the MgSt powders to understand the impact of these differences. JF - AAPS PharmSciTech AU - Gupta, Abhay AU - Hamad, Mazen L AU - Tawakkul, Mobin AU - Sayeed, Vilayat A AU - Khan, Mansoor A AD - Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Science, Food and Drug Administration, 10903 New Hampshire Avenue, LS building 64, Silver Spring, Maryland 20993-002, USA, Mansoor.khan@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 500 EP - 504 PB - Springer New York LLC VL - 10 IS - 2 SN - 1530-9932, 1530-9932 KW - Biotechnology and Bioengineering Abstracts KW - Granules KW - Powder KW - Vegetables KW - Tablets KW - Dissolution KW - Magnesium KW - Compression KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21132449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+PharmSciTech&rft.atitle=Difference+in+the+Lubrication+Efficiency+of+Bovine+and+Vegetable-Derived+Magnesium+Stearate+During+Tabletting&rft.au=Gupta%2C+Abhay%3BHamad%2C+Mazen+L%3BTawakkul%2C+Mobin%3BSayeed%2C+Vilayat+A%3BKhan%2C+Mansoor+A&rft.aulast=Gupta&rft.aufirst=Abhay&rft.date=2009-06-01&rft.volume=10&rft.issue=2&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=AAPS+PharmSciTech&rft.issn=15309932&rft_id=info:doi/10.1208%2Fs12249-009-9229-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Granules; Powder; Vegetables; Tablets; Dissolution; Magnesium; Compression DO - http://dx.doi.org/10.1208/s12249-009-9229-y ER - TY - JOUR T1 - Disintegration of Highly Soluble Immediate Release Tablets: A Surrogate for Dissolution AN - 21123605; 11177159 AB - The purpose of the work was to investigate correlation between disintegration and dissolution for immediate release tablets containing a high solubility drug and to identify formulations where disintegration test, instead of the dissolution test, may be used as the acceptance criteria based on International Conference on Harmonization Q6A guidelines. A statistical design of experiments was used to study the effect of filler, binder, disintegrating agent, and tablet hardness on the disintegration and dissolution of verapamil hydrochloride tablets. All formulation variables, i.e., filler, binder, and disintegrating agent, were found to influence tablet dissolution and disintegration, with the filler and disintegrating agent exerting the most significant influence. Slower dissolution was observed with increasing disintegration time when either the filler or the disintegrating agent was kept constant. However, no direct corelationship was observed between the disintegration and dissolution across all formulations due to the interactions between different formulation components. Although all tablets containing sodium carboxymethyl cellulose as the disintegrating agent, disintegrated in less than 3 min, half of them failed to meet the US Pharmacopeia 30 dissolution criteria for the verapamil hydrochloride tablets highlighting the dependence of dissolution process on the formulation components other than the disintegrating agent. The results identified only one formulation as suitable for using the disintegration test, instead of the dissolution test, as drug product acceptance criteria and highlight the need for systematic studies before using the disintegration test, instead of the dissolution test as the drug acceptance criteria. JF - AAPS PharmSciTech AU - Gupta, Abhay AU - Hunt, Robert L AU - Shah, Rakhi B AU - Sayeed, Vilayat A AU - Khan, Mansoor A AD - Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Science, Food and Drug Administration, 10903 New Hampshire Avenue, LS Bldg 64, Silver Spring, Maryland 20993-002, USA, Mansoor.khan@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 495 EP - 499 PB - Springer New York LLC VL - 10 IS - 2 SN - 1530-9932, 1530-9932 KW - Biotechnology and Bioengineering Abstracts KW - Sodium KW - Carboxymethylcellulose KW - Verapamil KW - Statistics KW - Solubility KW - Conferences KW - Tablets KW - Dissolution KW - Drugs KW - W 30970:Book & Conference Notices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21123605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+PharmSciTech&rft.atitle=Disintegration+of+Highly+Soluble+Immediate+Release+Tablets%3A+A+Surrogate+for+Dissolution&rft.au=Gupta%2C+Abhay%3BHunt%2C+Robert+L%3BShah%2C+Rakhi+B%3BSayeed%2C+Vilayat+A%3BKhan%2C+Mansoor+A&rft.aulast=Gupta&rft.aufirst=Abhay&rft.date=2009-06-01&rft.volume=10&rft.issue=2&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=AAPS+PharmSciTech&rft.issn=15309932&rft_id=info:doi/10.1208%2Fs12249-009-9227-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sodium; Carboxymethylcellulose; Solubility; Statistics; Verapamil; Conferences; Tablets; Dissolution; Drugs DO - http://dx.doi.org/10.1208/s12249-009-9227-0 ER - TY - JOUR T1 - Isolation and Characterization of Glyceraldehyde-3-phosphate Dehydrogenase Gene of Trichoderma virens UKM1 AN - 20883076; 10824029 JF - Biotechnology AU - Oh, SSL AU - Bakar, FDA AU - Adrian, A M AU - Mahadi, N M AU - Hassan, O AU - Murad, AMA Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 194 EP - 203 VL - 8 IS - 2 SN - 1682-296X, 1682-296X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Glyceraldehyde-3-phosphate dehydrogenase KW - Hypocrea virens KW - K 03330:Biochemistry KW - W 30965:Miscellaneous, Reviews KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20883076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology&rft.atitle=Isolation+and+Characterization+of+Glyceraldehyde-3-phosphate+Dehydrogenase+Gene+of+Trichoderma+virens+UKM1&rft.au=Oh%2C+SSL%3BBakar%2C+FDA%3BAdrian%2C+A+M%3BMahadi%2C+N+M%3BHassan%2C+O%3BMurad%2C+AMA&rft.aulast=Oh&rft.aufirst=SSL&rft.date=2009-06-01&rft.volume=8&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Biotechnology&rft.issn=1682296X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Glyceraldehyde-3-phosphate dehydrogenase; Hypocrea virens ER - TY - JOUR T1 - Acute vibration reduces A beta nerve fiber sensitivity and alters gene expression in the ventral tail nerves of rats AN - 20871307; 9379933 AB - Long-term occupational exposure to hand-arm vibration can result in a permanent reduction in tactile sensitivity in exposed fingers and hands. Little is known about how vibration causes this reduction in sensitivity, and currently no testing procedures have been developed to monitor changes in sensory perception during ongoing exposures. We used a rat-tail model of hand-arm vibration syndrome (HAVS) to determine whether changes in sensory nerve function could be detected after acute exposure to vibration. Nerve function was assessed using the current perception threshold (CPT) method. We also determined whether changes in nerve function were associated with changes in gene transcription. Our results demonstrate that the CPT method can be used to assess sensory nerve function repeatedly in rats and can detect transient decreases in the sensitivity of A nerve fibers caused by acute exposure to vibration. This decrease in A fiber sensitivity was associated with a reduction in expression of nitric oxide synthase-1, and a modest increase in calcitonin gene-related peptide transcript levels in tail nerves 24 h after vibration exposure. These transient changes in sensory perception and transcript levels induced by acute vibration exposure may be indicators of more prolonged changes in peripheral nerve physiology. Muscle Nerve, 2007. JF - Muscle & Nerve AU - Krajnak, Kristine AU - Waugh, Stacey AU - Wirth, Oliver AU - Kashon, Michael L AD - Engineering and Control Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA, ksk1@cdc.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 39 IS - 6 SN - 0148-639X, 0148-639X KW - Genetics Abstracts; Health & Safety Science Abstracts; CSA Neurosciences Abstracts KW - Calcitonin gene-related peptide KW - Physiology KW - Models KW - Rats KW - Gene expression KW - hand-arm vibration syndrome KW - Occupational exposure KW - Sensitivity KW - Sensory neurons KW - Tails KW - Muscles KW - Hand KW - Transcription KW - Finger KW - Vibrations KW - Fibers KW - Antibodies KW - Perception KW - Vibration KW - Nitric oxide KW - Peripheral nerves KW - G 07880:Human Genetics KW - N3 11001:Behavioral and Cognitive Neuroscience KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20871307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Muscle+%26+Nerve&rft.atitle=Acute+vibration+reduces+A+beta+nerve+fiber+sensitivity+and+alters+gene+expression+in+the+ventral+tail+nerves+of+rats&rft.au=Krajnak%2C+Kristine%3BWaugh%2C+Stacey%3BWirth%2C+Oliver%3BKashon%2C+Michael+L&rft.aulast=Krajnak&rft.aufirst=Kristine&rft.date=2009-06-01&rft.volume=39&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Muscle+%26+Nerve&rft.issn=0148639X&rft_id=info:doi/10.1002%2Fmus.20799 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Calcitonin gene-related peptide; Sensory neurons; Tails; Muscles; Transcription; Hand; Finger; Models; Vibrations; Gene expression; Antibodies; Perception; Nitric oxide; Occupational exposure; Peripheral nerves; Rats; Fibers; Sensitivity; Vibration; Physiology; hand-arm vibration syndrome DO - http://dx.doi.org/10.1002/mus.20799 ER - TY - JOUR T1 - Detection and molecular characterization of swine hepatitis E virus in North Carolina swine herds and their faecal wastes AN - 20775446; 10281195 AB - Recent findings of almost genetically indistinguishable swine and human strains, have suggested swine play a role in the transmission of hepatitis E virus (HEV). The extent to which HEV may be present and persist in the faecal waste generated from intensive swine operations is largely unknown. The fate of swine waste liquid is often land application, possibly resulting in unintentional seepage into groundwater or run-off into surface waters, hence validating concerns of human exposure risks. Freshly passed swine faeces, barn flush liquid waste, and lagoon liquid from production sites in North Carolina were surveyed periodically for HEV using RT-PCR primers located in ORF2. On three farms where HEV RNA was detected in swine faeces, it was also found in stored liquid waste on several occasions. HEV presence was related to swine age but not to animal management and waste management procedures, which varied amongst the farms. Seasonal patterns of HEV prevalence could not be established as viral RNA was isolated at all time points from two farms. Phylogenetic analysis of 212 bases of the genomic RNA indicated that isolates resembled the known US swine and human strains (percentage nucleic acid homology 91 to 94%), with one amino acid substitution. JF - Journal of Water and Health AU - Kase, JA AU - Correa, M T AU - Sobsey, MD AD - Microbial Methods Development Branch Division of Microbiology, Office of Regulatory Sciences Center for Food Safety and Applied Nutrition, US Food and Drug Administration 5100, Paint Branch Parkway, Rm 3E-017, HFS-711, College Park, MD 20740, USA, julieannkase@gmail.com Y1 - 2009/06// PY - 2009 DA - June 2009 SP - 344 EP - 357 VL - 7 IS - 2 SN - 1477-8920, 1477-8920 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Virology & AIDS Abstracts; Pollution Abstracts; Environment Abstracts; Aqualine Abstracts; Water Resources Abstracts KW - USA, North Carolina KW - Amino acid substitution KW - Farms KW - Land application KW - Liquid wastes KW - genomics KW - Feces KW - Seasonal variations KW - Phylogenetics KW - Phylogeny KW - Amino acids KW - Wastes KW - Strains KW - Hepatitis KW - Liquid Wastes KW - Surface-groundwater Relations KW - RNA KW - Primers KW - Groundwater KW - Age KW - Surface water KW - Land Disposal KW - Strain KW - Lagoons KW - Public Health KW - Sulfur dioxide KW - farms KW - Ground water KW - Polymerase chain reaction KW - Seepages KW - Pollution detection KW - Hepatitis E virus KW - nucleic acids KW - Homology KW - Acids KW - seepages KW - Nucleic acids KW - Q5 08503:Characteristics, behavior and fate KW - P 2000:FRESHWATER POLLUTION KW - SW 3030:Effects of pollution KW - AQ 00003:Monitoring and Analysis of Water and Wastes KW - V 22310:Genetics, Taxonomy & Structure KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20775446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Water+and+Health&rft.atitle=Detection+and+molecular+characterization+of+swine+hepatitis+E+virus+in+North+Carolina+swine+herds+and+their+faecal+wastes&rft.au=Kase%2C+JA%3BCorrea%2C+M+T%3BSobsey%2C+MD&rft.aulast=Kase&rft.aufirst=JA&rft.date=2009-06-01&rft.volume=7&rft.issue=2&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=Journal+of+Water+and+Health&rft.issn=14778920&rft_id=info:doi/10.2166%2Fwh.2009.137 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Wastes; Polymerase chain reaction; Seepages; Strains; Lagoons; Phylogenetics; Nucleic acids; Phylogeny; Age; Farms; Amino acid substitution; Surface water; nucleic acids; RNA; Homology; Ground water; Primers; genomics; Feces; Seasonal variations; Amino acids; Pollution detection; Liquid wastes; Land application; Hepatitis; Sulfur dioxide; farms; seepages; Groundwater; Liquid Wastes; Public Health; Surface-groundwater Relations; Land Disposal; Acids; Strain; Hepatitis E virus; USA, North Carolina DO - http://dx.doi.org/10.2166/wh.2009.137 ER - TY - JOUR T1 - Development of a Computer Program for Permeation Testing Data Analysis AN - 20773230; 10311218 AB - A Microsoft Windows-compatible computer program, referred to as 'Permeation Calculator,' was developed at the National Institute for Occupational Safety and Health (NIOSH) to automate and standardize permeation testing data analysis. The program imports the data file collected during a permeation test and calculates relevant permeation parameters within a few seconds, based on a series of algorithms, strategies, and automated decision-making processes. It allows calculations of all the permeation parameters related to American Society for Testing and Materials (ASTM) F 739, International Organization for Standardization (ISO) 6529, and ASTM D 6978 standards, including standardized breakthrough time, normalized breakthrough time, breakthrough detection time, steady-state permeation rate, cumulative permeation mass at a given elapsed time, and elapsed time at a given cumulative permeation mass for either a closed-loop or an open-loop permeation test. For open-loop permeation testing, the software also allows changing sampling flowrate and allows calculations of average permeation rate and maximum permeation rate to see if the rates ever reach the threshold maximum for decision making. On completion, the software displays all the permeation parameters together with relevant information and the permeation curve as a report file in Microsoft Excel and text file formats. This software helps industrial hygienists and researchers to avoid labor-intensive hand calculations of the permeation parameters. The software also prevents experimenter bias, thus ensuring identical permeation parameters will be obtained from a given permeation testing data file. The Permeation Calculator is available either on the NIOSH website or on CD by request. JF - Journal of Occupational and Environmental Hygiene AU - Gao, Pengfei AU - Weise, Tyson AU - Tomasovic, Beth AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 363 EP - 373 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 6 IS - 6 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Computer programs KW - International Organization for Standardization KW - Occupational safety KW - Cadmium KW - imports KW - International standardization KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20773230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Development+of+a+Computer+Program+for+Permeation+Testing+Data+Analysis&rft.au=Gao%2C+Pengfei%3BWeise%2C+Tyson%3BTomasovic%2C+Beth&rft.aulast=Gao&rft.aufirst=Pengfei&rft.date=2009-06-01&rft.volume=6&rft.issue=6&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620902864973 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - International Organization for Standardization; Computer programs; Occupational safety; Cadmium; imports; International standardization DO - http://dx.doi.org/10.1080/15459620902864973 ER - TY - JOUR T1 - Residential Exposure to Polychlorinated Biphenyls and Organochlorine Pesticides and Risk of Childhood Leukemia AN - 20771142; 10295388 AB - Background: Incidence of childhood leukemia in industrialized countries rose significantly during 1975-2004, and the reasons for the increase are not understood. Objectives We used carpet dust as an exposure indicator to examine the risk of childhood leukemia in relation to residential exposure to persistent organochlorine chemicals: six polychlorinated biphenyl (PCB) congeners and the pesticides alpha - and gamma -chlordane, p,p'-DDT (dichlorodiphenyltrichloroethane), p,p'-DDE (dichlorodiphenyldichloroethylene), methoxychlor, and pentachlorophenol. Methods: We conducted a population-based case-control study in 35 counties in northern and central California in 2001-2006. The study included 184 acute lymphocytic leukemia (ALL) cases 0-7 years of age and 212 birth certificate controls matched to cases by birth date, sex, race, and Hispanic ethnicity. We collected carpet dust samples from the room where the child spent the most time before diagnosis (similar date for controls) using a specialized vacuum. Results: Detection of any PCB congener in the dust conferred a 2-fold increased risk of ALL [odds ratio (OR) = 1.97; 95% confidence interval (CI), 1.22-3.17]. Compared with those in the lowest quartile of total PCBs, the highest quartile was associated with about a 3-fold risk (OR = 2.78; 95% CI, 1.41-5.48), and the positive trend was significant (p = 0.017). Significant positive trends in ALL risk were apparent with increasing concentrations of PCB congeners 118, 138, and 153. We observed no significant positive associations for chlordane, DDT, DDE, methoxychlor, or pentachlorophenol. The associations with PCBs were stronger among non-Hispanic whites than among Hispanics despite similar distributions of PCB levels among controls in each racial/ethnic group. Conclusions: Our findings suggest that PCBs, which are considered probable human carcinogens and cause perturbations of the immune system, may represent a previously unrecognized risk factor for childhood leukemia. JF - Environmental Health Perspectives AU - Ward, Mary H AU - Colt, Joanne S AU - Metayer, Catherine AU - Gunier, Robert B AU - Lubin, Jay AU - Crouse, Vonda AU - Nishioka, Marcia G AU - Reynolds, Peggy AU - Buffler, Patricia A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 1007 EP - 1013 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 117 IS - 6 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts; Pollution Abstracts; Risk Abstracts; Immunology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - childhood cancer KW - dust KW - leukemia KW - organochlorine compounds KW - pesticides KW - polychlorinated biphenyls KW - Chemicals KW - Age KW - Organochlorine compounds KW - immune system KW - Immune system KW - Lymphatic leukemia KW - Carcinogens KW - Dust KW - Leukemia KW - Insecticides KW - Nitrous oxide KW - Carpets KW - Risk factors KW - Congeners KW - USA, California KW - PCB compounds KW - Pentachlorophenol KW - Ethnic groups KW - PCB KW - Races KW - Sex KW - Chlordane KW - DDE KW - pentachlorophenol KW - Vacuum KW - Pesticides (organochlorine) KW - Children KW - Birth KW - Pesticides KW - DDT KW - Residential areas KW - Methoxychlor KW - H 5000:Pesticides KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20771142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Residential+Exposure+to+Polychlorinated+Biphenyls+and+Organochlorine+Pesticides+and+Risk+of+Childhood+Leukemia&rft.au=Ward%2C+Mary+H%3BColt%2C+Joanne+S%3BMetayer%2C+Catherine%3BGunier%2C+Robert+B%3BLubin%2C+Jay%3BCrouse%2C+Vonda%3BNishioka%2C+Marcia+G%3BReynolds%2C+Peggy%3BBuffler%2C+Patricia+A&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2009-06-01&rft.volume=117&rft.issue=6&rft.spage=1007&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0900583 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Organochlorine compounds; Chlordane; Immune system; DDE; Lymphatic leukemia; Pesticides (organochlorine); Vacuum; Carcinogens; Children; Dust; Birth; polychlorinated biphenyls; Carpets; Risk factors; DDT; Methoxychlor; Congeners; Pentachlorophenol; Races; PCB; Ethnic groups; Sex; Chemicals; Age; immune system; pentachlorophenol; Leukemia; Insecticides; Nitrous oxide; Pesticides; Residential areas; PCB compounds; USA, California DO - http://dx.doi.org/10.1289/ehp.0900583 ER - TY - JOUR T1 - Police Work and Subclinical Atherosclerosis AN - 20687544; 10191548 AB - Objective: Employment as an urban police officer was hypothesized to be associated with increased structural subclinical cardiovascular disease (CVD), measured by carotid artery intima-media thickness (IMT). Methods: The sample of men and women consisted of police officers (h = 312) and the general population (N = 318), free of clinical CVD. Results: Officers had elevated levels of age-adjusted CVD risk factors (blood pressure, total cholesterol, smoking prevalence) compared with the population sample. In age-, gender-, and traditional risk factor-adjusted models, police officers exhibited increased mean common carotid IMT (police = 0.67 mm, population= 0.64 mm; P = 0.03) and mean maximum carotid IMT (police = 0.99 mm, population = 0.95 mm; P = 0.13). Conclusions: Police officers have increased levels of atherosclerosis compared with a general population sample, which was not fully explained by elevated CVD risk factors; thereby potentially implicating other mechanisms whereby law enforcement work may increase CVD risk. JF - Journal of Occupational and Environmental Medicine AU - Joseph, P N AU - Violanti, J M AU - Donahue, R AU - Andrew, ME AU - Trevisan, M AU - Burchfiel, C M AU - Dorn, J AD - NIOSH/CDC, 1095 iWillowdale Road M/S 4050, Morgantown, WV, 26505, USA, PNJoseph@cdc.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 700 EP - 707 VL - 51 IS - 6 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Smoking KW - employment KW - police KW - occupational diseases KW - law enforcement KW - Cardiovascular diseases KW - cholesterol KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20687544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Police+Work+and+Subclinical+Atherosclerosis&rft.au=Joseph%2C+P+N%3BViolanti%2C+J+M%3BDonahue%2C+R%3BAndrew%2C+ME%3BTrevisan%2C+M%3BBurchfiel%2C+C+M%3BDorn%2C+J&rft.aulast=Joseph&rft.aufirst=P&rft.date=2009-06-01&rft.volume=51&rft.issue=6&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181a02252 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoking; employment; occupational diseases; police; law enforcement; Cardiovascular diseases; cholesterol; Occupational health DO - http://dx.doi.org/10.1097/JOM.0b013e3181a02252 ER - TY - JOUR T1 - Effect of long chain fatty acids on Salmonella killing, superoxide and nitric oxide production by chicken macrophages AN - 20600613; 9312354 AB - The objective of this study was to investigate the effect of uptake of different commonly consumed long chain fatty acids on superoxide (O2-), nitric oxide (NO) production, and ability to kill Salmonella enterica serotype typhimurium (S. typhimurium) by chicken macrophages (HD11 cells). All the fatty acids were taken up by HD11 cells with stearic acid uptake higher than polyunsaturated fatty acids. Uptake of green fluorescent protein-labeled bacteria and the viability of HD11 cells (measured by flow cytometry) was not affected by any of the fatty acids tested. Bacterial clearance (measured by the plating of sorted viable infected cells) was significantly higher with n - 3 fatty acids a-linolenic acid (ALA) and docosahexanoic acid (DHA). However, stearic acid (SA) and the n - 6 fatty acid, arachidonic acid (ARA) did not influence S. typhimurium killing by HD11 cells. The improved S. typhimurium clearance by ALA and DHA was not associated with increased NO or O2- production by HD11 cells. These results suggest a role for n - 3 polyunsaturated fatty acids in Salmonella clearance by chicken macrophages however in vivo studies are essential to confirm their efficacy in controlling Salmonella infection in chickens and contamination in shell eggs. JF - International Journal of Food Microbiology AU - Babu, Uma AU - Wiesenfeld, Paddy AU - Gaines, Dennis AU - Raybourne, Richard B AD - Immunobiology Branch, Food and Drug Administration, Laurel, MD 20708, USA, uma.babu@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 67 EP - 72 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 132 IS - 1 SN - 0168-1605, 0168-1605 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Fatty acid uptake KW - Chicken macrophage functions KW - S. typhimurium KW - Stearic acid KW - Macrophages KW - Serotypes KW - Arachidonic acid KW - Salmonella typhimurium KW - Food contamination KW - Infection KW - Eggs KW - Flow cytometry KW - Salmonella enterica KW - Superoxide KW - Fatty acids KW - Polyunsaturated fatty acids KW - Nitric oxide KW - Shells KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20600613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Effect+of+long+chain+fatty+acids+on+Salmonella+killing%2C+superoxide+and+nitric+oxide+production+by+chicken+macrophages&rft.au=Babu%2C+Uma%3BWiesenfeld%2C+Paddy%3BGaines%2C+Dennis%3BRaybourne%2C+Richard+B&rft.aulast=Babu&rft.aufirst=Uma&rft.date=2009-06-01&rft.volume=132&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2009.03.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Stearic acid; Serotypes; Arachidonic acid; Infection; Food contamination; Eggs; Flow cytometry; Superoxide; Fatty acids; Polyunsaturated fatty acids; Nitric oxide; Shells; Salmonella enterica; Salmonella typhimurium DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2009.03.017 ER - TY - JOUR T1 - Reservoir Based Fentanyl Transdermal Drug Delivery Systems: Effect of Patch Age on Drug Release and Skin Permeation AN - 20594322; 9299559 AB - Purpose: To understand and evaluate the stability and skin permeation profiles of fentanyl reservoir systems as a function of patch age. Methods: Drug release and skin permeation studies were performed using a modified USP apparatus 5 with a novel sample preparation technique. Results: The amount of fentanyl present in the EVA/adhesive layer (EAL) increased from about 17% of label claim (LC) at 5 months to 25% LC at 22 months. The increase in the drug concentration was mainly observed in the peripheral EAL. Simultaneously, the alcohol content of the patch decreased as a function of patch age. A significant effect of patch age on the drug content in the EAL and the drug release from the system was observed; however, skin permeation studies did not indicate an increase in drug delivery rate. Conclusions: Novel sample preparation technique with USP Apparatus 5 allowed determination of in vitro skin permeation rates for fentanyl transdermal patches with different designs. Permeation rates with cadaver skin as substrate were found not to change with patch age despite changing drug concentration in the EAL. JF - Pharmaceutical Research AU - Prodduturi, Suneela AU - Smith, Glen J AU - Wokovich, Anna M AU - Doub, William H AU - Westenberger, Benjamin J AU - Buhse, Lucinda AD - Division of Pharmaceutical Analysis, U.S. Food and Drug Administration, 1114 Market St. Rm 1002, St. Louis, Missouri, 63101, USA, suneela.prodduturi@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 1344 EP - 1352 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 26 IS - 6 SN - 0724-8741, 0724-8741 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Age KW - Skin KW - alcohols KW - Cadavers KW - fentanyl KW - Adhesives KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20594322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+Research&rft.atitle=Reservoir+Based+Fentanyl+Transdermal+Drug+Delivery+Systems%3A+Effect+of+Patch+Age+on+Drug+Release+and+Skin+Permeation&rft.au=Prodduturi%2C+Suneela%3BSmith%2C+Glen+J%3BWokovich%2C+Anna+M%3BDoub%2C+William+H%3BWestenberger%2C+Benjamin+J%3BBuhse%2C+Lucinda&rft.aulast=Prodduturi&rft.aufirst=Suneela&rft.date=2009-06-01&rft.volume=26&rft.issue=6&rft.spage=1344&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+Research&rft.issn=07248741&rft_id=info:doi/10.1007%2Fs11095-009-9843-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Drug delivery; Age; Skin; Cadavers; alcohols; Adhesives; fentanyl DO - http://dx.doi.org/10.1007/s11095-009-9843-0 ER - TY - JOUR T1 - Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans. Part A: Use of FDA post-market reports to create a database of hepatobiliary and urinary tract toxicities AN - 20567992; 9275139 AB - The Informatics and Computational Safety Analysis Staff at the US FDA's Center for Drug Evaluation and Research has created a database of pharmaceutical adverse effects (AEs) linked to pharmaceutical chemical structures and estimated population exposures. The database is being used to develop quantitative structure-activity relationship (QSAR) models for the prediction of drug-induced liver and renal injury, as well as to identify relationships among AEs. The post-market observations contained in the database were obtained from FDA's Spontaneous Reporting System (SRS) and the Adverse Event Reporting System (AERS) accessed through Elsevier PharmaPendium(TM) software. The database contains approximately 3100 unique pharmaceutical compounds and 9685 AE endpoints. To account for variations in AE reports due to different patient populations and exposures for each drug, a proportional reporting ratio (PRR) was used. The PRR was applied to all AEs to identify chemicals that could be scored as positive in the training data sets of QSAR models. Additionally, toxicologically similar AEs were grouped into clusters based upon both biological effects and statistical correlation. This clustering created a weight of evidence paradigm for the identification of compounds most likely to cause human harm based upon findings in multiple related AE endpoints. JF - Regulatory Toxicology and Pharmacology AU - Ursem, C J AU - Kruhlak, N L AU - Contrera, J F AU - MacLaughlin, P M AU - Benz, R D AU - Matthews, E J AD - Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff (ICSAS), 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA, Edwin.Matthews@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 1 EP - 22 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 54 IS - 1 SN - 0273-2300, 0273-2300 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Statistics KW - Injuries KW - biological effects KW - Informatics KW - Urinary tract KW - Models KW - Computer programs KW - software KW - informatics KW - Drugs KW - structure-activity relationships KW - Data processing KW - Drug development KW - Toxicity KW - Computer applications KW - Databases KW - Urine KW - FDA KW - Kidney KW - Liver KW - Pharmaceuticals KW - Structure-activity relationships KW - Side effects KW - X 24310:Pharmaceuticals KW - H 14000:Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20567992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Identification+of+structure-activity+relationships+for+adverse+effects+of+pharmaceuticals+in+humans.+Part+A%3A+Use+of+FDA+post-market+reports+to+create+a+database+of+hepatobiliary+and+urinary+tract+toxicities&rft.au=Ursem%2C+C+J%3BKruhlak%2C+N+L%3BContrera%2C+J+F%3BMacLaughlin%2C+P+M%3BBenz%2C+R+D%3BMatthews%2C+E+J&rft.aulast=Ursem&rft.aufirst=C&rft.date=2009-06-01&rft.volume=54&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2008.12.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Statistics; Injuries; Informatics; Drug development; Urinary tract; Toxicity; Computer applications; Models; Databases; Computer programs; software; Liver; Kidney; Pharmaceuticals; Structure-activity relationships; Drugs; Side effects; structure-activity relationships; informatics; biological effects; Urine; FDA DO - http://dx.doi.org/10.1016/j.yrtph.2008.12.009 ER - TY - JOUR T1 - Few effects of multi-generational dietary exposure to genistein or nonylphenol on sodium solution intake in male and female Sprague-Dawley rats AN - 20523917; 9211179 AB - Previous work in our laboratory indicated that lifelong dietary exposure to estrogen-like endocrine disrupters increased sodium solution intake in adult male and female rats. Here, we sought to discern the critical periods necessary for this alteration as well as establish the effects of lower dietary concentrations of genistein and nonylphenol. Male and female Sprague-Dawley rats (F0) consumed phytoestrogen-free chow containing 0, 5, 100, or 500 ppm genistein (0.0, 0.4, 8.0, and 40.0 mg/kg/day) or 0, 25, 200, or 750 ppm nonylphenol (0.0, 2.0, 16.0, and 60.0 mg/kg/day). Rats were mated within treatment groups and offspring (F1) maintained on the same diets. Mating for the F1, F2, and F3 (genistein only) was within treatment groups. At postnatal day (PND) 21, the F3 generation began to consume unadulterated phytoestrogen-free chow such that genistein exposure occurred only in utero and preweaning. The F4 generation was never directly exposed to genistein. On PNDs 65-68, intake of regular water and a 3.0% sodium chloride solution was measured for F1-F4 generations (genistein portion) or F1-F2 (nonylphenol portion). Although body weights were decreased by the highest dietary concentrations of genistein and nonylphenol, there were only minimal effects of exposure on sodium solution intake. As expected, intake was highest in female rats. With previous data, these results indicate that the dietary concentrations necessary to increase adult sodium solution intake in rats are greater than 500 ppm genistein and 750 ppm nonylphenol and such effects do not appear to increase across generations. JF - Neurotoxicology and Teratology AU - Ferguson, SA AU - Delclos, K B AU - Newbold, R R AU - Flynn, K M AD - National Center for Toxicological Research/FDA, Jefferson, AR 72079, United States, Sherry.Ferguson@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 143 EP - 148 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 31 IS - 3 SN - 0892-0362, 0892-0362 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Diets KW - Mating KW - Data processing KW - Body weight KW - Nonylphenol KW - Progeny KW - Critical period KW - Genistein KW - Sodium chloride KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20523917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Few+effects+of+multi-generational+dietary+exposure+to+genistein+or+nonylphenol+on+sodium+solution+intake+in+male+and+female+Sprague-Dawley+rats&rft.au=Ferguson%2C+SA%3BDelclos%2C+K+B%3BNewbold%2C+R+R%3BFlynn%2C+K+M&rft.aulast=Ferguson&rft.aufirst=SA&rft.date=2009-06-01&rft.volume=31&rft.issue=3&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2009.01.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Mating; Data processing; Body weight; Nonylphenol; Progeny; Critical period; Sodium chloride; Genistein DO - http://dx.doi.org/10.1016/j.ntt.2009.01.009 ER - TY - JOUR T1 - Planning a serial dilution test with multiple dilutions AN - 20521555; 9211164 AB - The dilutions used in a serial dilution test determine which concentrations it can estimate well. Two criteria help to select how many and which dilutions to use. The first criterion is a low probability of outcomes with either all growth or all non-growth tubes at the concentrations of interest. The second criterion considers how far the estimated concentration (MPN) is likely to be from the actual concentration. JF - Food Microbiology AU - Blodgett, R J AD - Room 2D-011 (HFS-012), 5100 Paint Branch Parkway, College Park 20740, United States, robert.blodgett@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 421 EP - 424 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 26 IS - 4 SN - 0740-0020, 0740-0020 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Dilution tests KW - A 01330:Food Microbiology KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20521555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Planning+a+serial+dilution+test+with+multiple+dilutions&rft.au=Blodgett%2C+R+J&rft.aulast=Blodgett&rft.aufirst=R&rft.date=2009-06-01&rft.volume=26&rft.issue=4&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2009.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Dilution tests DO - http://dx.doi.org/10.1016/j.fm.2009.02.001 ER - TY - JOUR T1 - Proteomic applications to elucidate bacterial aromatic hydrocarbon metabolic pathways AN - 20132419; 10132918 AB - The growing availability of genome sequences and advancement of high-throughput omics and analytical chemistry technologies have reinvigorated the study of biodegradation processes in aromatic hydrocarbon catabolism. In particular, proteomics approaches globally have identified and quantified bacterial enzymes responsible for aromatic hydrocarbon metabolism, which significantly assists in determining strategies for the biodegradation of aromatic hydrocarbons with applications in environmental bioremediation. JF - Current Opinion in Microbiology AU - Kim, Seong-Jae AU - Kweon, Ohgew AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR, United States, carl.cerniglia@fda.hhs.gov Y1 - 2009/06// PY - 2009 DA - Jun 2009 SP - 301 EP - 309 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 12 IS - 3 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Water Resources Abstracts KW - Bacteria KW - Hydrocarbons KW - Aromatic hydrocarbons KW - SW 0540:Properties of water KW - J 02320:Cell Biology KW - A 01320:Microbial Degradation KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20132419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=Proteomic+applications+to+elucidate+bacterial+aromatic+hydrocarbon+metabolic+pathways&rft.au=Kim%2C+Seong-Jae%3BKweon%2C+Ohgew%3BCerniglia%2C+Carl+E&rft.aulast=Kim&rft.aufirst=Seong-Jae&rft.date=2009-06-01&rft.volume=12&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/10.1016%2Fj.mib.2009.03.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Aromatic hydrocarbons; Hydrocarbons; Bacteria DO - http://dx.doi.org/10.1016/j.mib.2009.03.006 ER - TY - CPAPER T1 - Global warming and development of harmful algal blooms species in Eastern Baltic Sea T2 - 2009 Annual Meeting of the UK branch of the Society of Environmental Toxicology and Chemistry (SETAC 2009) AN - 42111730; 5139963 JF - 2009 Annual Meeting of the UK branch of the Society of Environmental Toxicology and Chemistry (SETAC 2009) AU - Balode, M AU - Purvina, S AU - Purina, I AU - Strode, E AU - Putna, I AU - Balodis, J AU - Pfeifere, M AU - Yurkovska, V AU - Barda, I Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Baltic Sea KW - Climatic changes KW - Global warming KW - Greenhouse gases KW - Algal blooms KW - Phytoplankton KW - Biological poisons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42111730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+UK+branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry+%28SETAC+2009%29&rft.atitle=Global+warming+and+development+of+harmful+algal+blooms+species+in+Eastern+Baltic+Sea&rft.au=Balode%2C+M%3BPurvina%2C+S%3BPurina%2C+I%3BStrode%2C+E%3BPutna%2C+I%3BBalodis%2C+J%3BPfeifere%2C+M%3BYurkovska%2C+V%3BBarda%2C+I&rft.aulast=Balode&rft.aufirst=M&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+UK+branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry+%28SETAC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://goteborg.setac.eu/embed/downloads/AM09_Scientific_Programme.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environmental risk assessment of veterinary pharmaceuticals in the US: application of VICH T2 - 2009 Annual Meeting of the UK branch of the Society of Environmental Toxicology and Chemistry (SETAC 2009) AN - 42106270; 5140223 JF - 2009 Annual Meeting of the UK branch of the Society of Environmental Toxicology and Chemistry (SETAC 2009) AU - Eirkson III, E AU - Silberhorn, E Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Environmental assessment KW - Risk assessment KW - Pharmaceuticals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42106270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+UK+branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry+%28SETAC+2009%29&rft.atitle=Environmental+risk+assessment+of+veterinary+pharmaceuticals+in+the+US%3A+application+of+VICH&rft.au=Eirkson+III%2C+E%3BSilberhorn%2C+E&rft.aulast=Eirkson+III&rft.aufirst=E&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+UK+branch+of+the+Society+of+Environmental+Toxicology+and+Chemistry+%28SETAC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://goteborg.setac.eu/embed/downloads/AM09_Scientific_Programme.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Proteomic Analysis of Mouse Lymph Nodes Exposed to Titanium Dioxide Nanoparticles T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40377535; 5280791 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Gao, Yuan AU - Gopee, Neera AU - Holland, Ricky AU - Howard, Paul AU - Yu, Li-Rong Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Titanium dioxide KW - Lymph nodes KW - Proteomics KW - Nanoparticles KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40377535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Quantitative+Proteomic+Analysis+of+Mouse+Lymph+Nodes+Exposed+to+Titanium+Dioxide+Nanoparticles&rft.au=Gao%2C+Yuan%3BGopee%2C+Neera%3BHolland%2C+Ricky%3BHoward%2C+Paul%3BYu%2C+Li-Rong&rft.aulast=Gao&rft.aufirst=Yuan&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in the Maternal Serum Proteome Between the 1st and 3rd Trimesters of Uncomplicated Pregnancy in Nepal T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40377160; 5282526 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Scholl, Peter AU - Gucek, Marjan AU - Diez, Roberto AU - Ruczinski, Ingo AU - Rennie, Alissa AU - Nathasingh, Chris AU - Cole, Robert AU - Yager, James AU - Groopman, John AU - Schulze, Kerry AU - Christian, Parul AU - West, Keith Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Nepal KW - Pregnancy KW - Serum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40377160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Changes+in+the+Maternal+Serum+Proteome+Between+the+1st+and+3rd+Trimesters+of+Uncomplicated+Pregnancy+in+Nepal&rft.au=Scholl%2C+Peter%3BGucek%2C+Marjan%3BDiez%2C+Roberto%3BRuczinski%2C+Ingo%3BRennie%2C+Alissa%3BNathasingh%2C+Chris%3BCole%2C+Robert%3BYager%2C+James%3BGroopman%2C+John%3BSchulze%2C+Kerry%3BChristian%2C+Parul%3BWest%2C+Keith&rft.aulast=Scholl&rft.aufirst=Peter&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mass Spectrometry Characterization of hCenexin1 Phosphorylation Vital to Polo-like Kinase 1 (Plk1) Interaction for Mitotic Functions T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40374176; 5282432 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Yu, Li-Rong AU - Soung, Nak-Kyun AU - Park, Jung-Eun AU - Lee, Kyung AU - Lee, Jung-Min AU - Bang, Jeong AU - Veenstra, Timothy AU - Rhee, Kunsoo Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Polo-like kinase 1 KW - Phosphorylation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40374176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+Social+Worker&rft.atitle=The+4+L%27s+to+a+Solid+Professional+Identity&rft.au=Fink-Samnick%2C+Ellen%2C+MSW%2C+ACSW%2C+LCSW%2C+CCM%2C+CRP&rft.aulast=Fink-Samnick&rft.aufirst=Ellen&rft.date=2016-10-01&rft.volume=23&rft.issue=4&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=The+New+Social+Worker&rft.issn=10737871&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An LC/MS Platform for Aminated Oligosaccharide Analysis in Both Positive and Negative modes: towards more complete structural assignment T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40373946; 5282483 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Jankowska, Ewa AU - Cipollo, John Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Oligosaccharides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40373946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=An+LC%2FMS+Platform+for+Aminated+Oligosaccharide+Analysis+in+Both+Positive+and+Negative+modes%3A+towards+more+complete+structural+assignment&rft.au=Jankowska%2C+Ewa%3BCipollo%2C+John&rft.aulast=Jankowska&rft.aufirst=Ewa&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Elucidation of Isocyanate-Peptide Adducts Using Tandem Mass Spectrometry T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40368200; 5281277 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Hettick, Justin AU - Ruwona, Tinashe AU - Siegel, Paul Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Adducts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40368200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Structural+Elucidation+of+Isocyanate-Peptide+Adducts+Using+Tandem+Mass+Spectrometry&rft.au=Hettick%2C+Justin%3BRuwona%2C+Tinashe%3BSiegel%2C+Paul&rft.aulast=Hettick&rft.aufirst=Justin&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Temporal Analysis of the Bovine Innate Immune Response: The Identification and Characterization of Antimicrobial Peptides by Mass Spectrometry T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40367875; 5281171 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - DeGrasse, Jeffrey AU - Boehmer, Jamie AU - Shefcheck, Kevin AU - Ward, Jeffrey AU - Callahan, John Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Immune response KW - Antimicrobial agents KW - Antimicrobial peptides KW - Peptides KW - Immunity KW - Defense mechanisms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40367875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=A+Temporal+Analysis+of+the+Bovine+Innate+Immune+Response%3A+The+Identification+and+Characterization+of+Antimicrobial+Peptides+by+Mass+Spectrometry&rft.au=DeGrasse%2C+Jeffrey%3BBoehmer%2C+Jamie%3BShefcheck%2C+Kevin%3BWard%2C+Jeffrey%3BCallahan%2C+John&rft.aulast=DeGrasse&rft.aufirst=Jeffrey&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiplex analysis of food allergens using immunoprecipitation and mass spectrometry T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40367547; 5281168 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Shefcheck, Kevin AU - Li, Jinxi AU - Fenselau, Catherine AU - Callahan, John AU - Musser, Steve Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Allergens KW - Immunoprecipitation KW - Food hypersensitivity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40367547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Multiplex+analysis+of+food+allergens+using+immunoprecipitation+and+mass+spectrometry&rft.au=Shefcheck%2C+Kevin%3BLi%2C+Jinxi%3BFenselau%2C+Catherine%3BCallahan%2C+John%3BMusser%2C+Steve&rft.aulast=Shefcheck&rft.aufirst=Kevin&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Confirmation of Azaspiracid Toxins in Outbreak Implicated Mussel Products T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40365932; 5282821 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Abraham, Ann AU - Plakas, Steven AU - Granade, Hudson AU - El Said, Kathleen AU - Dickey, Robert Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Outbreaks KW - Toxins KW - Azaspiracids KW - Marine molluscs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40365932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Confirmation+of+Azaspiracid+Toxins+in+Outbreak+Implicated+Mussel+Products&rft.au=Abraham%2C+Ann%3BPlakas%2C+Steven%3BGranade%2C+Hudson%3BEl+Said%2C+Kathleen%3BDickey%2C+Robert&rft.aulast=Abraham&rft.aufirst=Ann&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Mass Spectrometry Based Glycomic Approach for Identification of Carbohydrate Dependant Virulence Factors Using Caenorhabditis elegans as a Surrogate Host T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40364975; 5281262 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Rahman, Mizanur AU - Hodgkin, Jonathan AU - Cipollo, John Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - Carbohydrates KW - Virulence factors KW - Caenorhabditis elegans KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40364975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=A+Mass+Spectrometry+Based+Glycomic+Approach+for+Identification+of+Carbohydrate+Dependant+Virulence+Factors+Using+Caenorhabditis+elegans+as+a+Surrogate+Host&rft.au=Rahman%2C+Mizanur%3BHodgkin%2C+Jonathan%3BCipollo%2C+John&rft.aulast=Rahman&rft.aufirst=Mizanur&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relative Quantification of Differentially Expressed Proteins in Bovine Milk during Coliform Mastitis using Spectral Count Data T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40364744; 5281172 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Boehmer, Jamie AU - Ward, Jeffrey AU - Bannerman, Douglas AU - Shefcheck, Kevin AU - Mcfarland, Melinda AU - Callahan, John Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Coliforms KW - Milk KW - Mastitis KW - Cow's milk KW - Data processing KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40364744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Relative+Quantification+of+Differentially+Expressed+Proteins+in+Bovine+Milk+during+Coliform+Mastitis+using+Spectral+Count+Data&rft.au=Boehmer%2C+Jamie%3BWard%2C+Jeffrey%3BBannerman%2C+Douglas%3BShefcheck%2C+Kevin%3BMcfarland%2C+Melinda%3BCallahan%2C+John&rft.aulast=Boehmer&rft.aufirst=Jamie&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficient Validation and Qualification of Mass Spectrometry Systems in a GLP- and GMP-Regulated Environment T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40364152; 5282676 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Palmer, Cynthia AU - James, Douglas AU - Rocci, Mario Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Mass spectroscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40364152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Efficient+Validation+and+Qualification+of+Mass+Spectrometry+Systems+in+a+GLP-+and+GMP-Regulated+Environment&rft.au=Palmer%2C+Cynthia%3BJames%2C+Douglas%3BRocci%2C+Mario&rft.aulast=Palmer&rft.aufirst=Cynthia&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-pressure assisted in-gel tryptic digest: qualitative and quantitative aspects T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40363901; 5281554 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Alterman, Michail AU - Getie-Kebtie, Melkamu AU - Lazarev, Alexander AU - Gross, Vera Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Digestion KW - Animal physiology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40363901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=High-pressure+assisted+in-gel+tryptic+digest%3A+qualitative+and+quantitative+aspects&rft.au=Alterman%2C+Michail%3BGetie-Kebtie%2C+Melkamu%3BLazarev%2C+Alexander%3BGross%2C+Vera&rft.aulast=Alterman&rft.aufirst=Michail&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dart-Ms/Ms Analysis of Foamed Pvc Jar Lids T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40361869; 5282993 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Ackerman, Luke AU - Noonan, Gregory AU - Begley, Timothy AU - Simoneau, Catherine AU - Suman, Michele Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40361869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Dart-Ms%2FMs+Analysis+of+Foamed+Pvc+Jar+Lids&rft.au=Ackerman%2C+Luke%3BNoonan%2C+Gregory%3BBegley%2C+Timothy%3BSimoneau%2C+Catherine%3BSuman%2C+Michele&rft.aulast=Ackerman&rft.aufirst=Luke&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Screening Phosphatidylcholine Injection Samples for Impurities by Hplc-Uv-Ms and Gc/Ms T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40360779; 5282832 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Dunn, Jamie AU - Woodruff, Jeffrey AU - Reepmeyer, John AU - Westenberger, Benjamin AU - Nasr, Samia AU - Hadwiger, Michael Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Impurities KW - Lecithin KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40360779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Screening+Phosphatidylcholine+Injection+Samples+for+Impurities+by+Hplc-Uv-Ms+and+Gc%2FMs&rft.au=Dunn%2C+Jamie%3BWoodruff%2C+Jeffrey%3BReepmeyer%2C+John%3BWestenberger%2C+Benjamin%3BNasr%2C+Samia%3BHadwiger%2C+Michael&rft.aulast=Dunn&rft.aufirst=Jamie&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Top-Down Identification of Bacterial Intact Protein Expression Profile Markers T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40360286; 5283056 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - McFarland, Melinda AU - Callahan, John AU - Andrzejewski, Denis AU - Bell, Rebecca AU - Musser, Steven Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Proteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40360286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Top-Down+Identification+of+Bacterial+Intact+Protein+Expression+Profile+Markers&rft.au=McFarland%2C+Melinda%3BCallahan%2C+John%3BAndrzejewski%2C+Denis%3BBell%2C+Rebecca%3BMusser%2C+Steven&rft.aulast=McFarland&rft.aufirst=Melinda&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fed and Fasted Physiology Plays Significant Role in Shaping the Rat Liver Lipid Droplet Proteome T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40359750; 5281942 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Abraham, Bindu AU - Sweredoski, Michael AU - Sztalryd, Carole AU - Hess, Sonja Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Lipids KW - Liver KW - Physiology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Fed+and+Fasted+Physiology+Plays+Significant+Role+in+Shaping+the+Rat+Liver+Lipid+Droplet+Proteome&rft.au=Abraham%2C+Bindu%3BSweredoski%2C+Michael%3BSztalryd%2C+Carole%3BHess%2C+Sonja&rft.aulast=Abraham&rft.aufirst=Bindu&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of Biogenic Amines in Seafood by Gc- and Lc-Ms T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40359706; 5282822 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Bencsath, F AU - Abraham, Ann Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Seafood KW - Amines KW - Biogenic amines KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Determination+of+Biogenic+Amines+in+Seafood+by+Gc-+and+Lc-Ms&rft.au=Bencsath%2C+F%3BAbraham%2C+Ann&rft.aulast=Bencsath&rft.aufirst=F&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacokinetic Analysis of Di(2-ethylhexyl)phthalate (DEHP) and its Major Metabolites in Plasma and Urine using UPLC with ES/MS/MS T2 - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AN - 40355145; 5281817 JF - 57th American Society for Mass Spectrometry Conference on Mass Spectrometry AU - Twaddle, Nathan AU - Moon, Steven AU - Camacho, Luisa AU - Delclos, Barry AU - Doerge, Daniel Y1 - 2009/05/31/ PY - 2009 DA - 2009 May 31 KW - Metabolites KW - Pharmacokinetics KW - Urine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.atitle=Pharmacokinetic+Analysis+of+Di%282-ethylhexyl%29phthalate+%28DEHP%29+and+its+Major+Metabolites+in+Plasma+and+Urine+using+UPLC+with+ES%2FMS%2FMS&rft.au=Twaddle%2C+Nathan%3BMoon%2C+Steven%3BCamacho%2C+Luisa%3BDelclos%2C+Barry%3BDoerge%2C+Daniel&rft.aulast=Twaddle&rft.aufirst=Nathan&rft.date=2009-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+American+Society+for+Mass+Spectrometry+Conference+on+Mass+Spectrometry&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Default.aspx?tabid=47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Updates on Biomarker Qualification Activities at FDA: Current Case Studies T2 - Biomarker World Congress 2009 AN - 42147422; 5149726 JF - Biomarker World Congress 2009 AU - Sanhai, Wendy Y1 - 2009/05/27/ PY - 2009 DA - 2009 May 27 KW - Case studies KW - Bioindicators KW - FDA KW - Biomarkers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42147422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Biomarker+World+Congress+2009&rft.atitle=Updates+on+Biomarker+Qualification+Activities+at+FDA%3A+Current+Case+Studies&rft.au=Sanhai%2C+Wendy&rft.aulast=Sanhai&rft.aufirst=Wendy&rft.date=2009-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Biomarker+World+Congress+2009&rft.issn=&rft_id=info:doi/ L2 - http://www.the-infoshop.com/conference/biomarker-world09/catalog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Perspective of the Role of In Vitro Diagnostics in Personalized Medicine T2 - Biomarker World Congress 2009 AN - 42147315; 5149708 JF - Biomarker World Congress 2009 AU - Gutierrez, Alberto Y1 - 2009/05/27/ PY - 2009 DA - 2009 May 27 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42147315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Biomarker+World+Congress+2009&rft.atitle=Regulatory+Perspective+of+the+Role+of+In+Vitro+Diagnostics+in+Personalized+Medicine&rft.au=Gutierrez%2C+Alberto&rft.aulast=Gutierrez&rft.aufirst=Alberto&rft.date=2009-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Biomarker+World+Congress+2009&rft.issn=&rft_id=info:doi/ L2 - http://www.the-infoshop.com/conference/biomarker-world09/catalog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Predictive Biomarkers: Using What's Been Learned from Past Regulatory Decisions to Inform Future Development Plans T2 - Biomarker World Congress 2009 AN - 42125463; 5149693 JF - Biomarker World Congress 2009 AU - Lesko, Lawrence Y1 - 2009/05/27/ PY - 2009 DA - 2009 May 27 KW - Bioindicators KW - Biomarkers KW - Prediction KW - Development projects KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42125463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Biomarker+World+Congress+2009&rft.atitle=Predictive+Biomarkers%3A+Using+What%27s+Been+Learned+from+Past+Regulatory+Decisions+to+Inform+Future+Development+Plans&rft.au=Lesko%2C+Lawrence&rft.aulast=Lesko&rft.aufirst=Lawrence&rft.date=2009-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Biomarker+World+Congress+2009&rft.issn=&rft_id=info:doi/ L2 - http://www.the-infoshop.com/conference/biomarker-world09/catalog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Activation of the 2-5OAS/RNase L pathway in CVB1 or HAV/18f infected FRhK-4 cells does not require induction of OAS1 or OAS2 expression AN - 20588691; 9275731 AB - The latent, constitutively expressed protein RNase L is activated in coxsackievirus and HAV strain 18f infected FRhK-4 cells. Endogenous oligoadenylate synthetase (OAS) from uninfected and virus infected cell extracts synthesizes active forms of the triphosphorylated 2-5A oligomer (the only known activator of RNase L) in vitro and endogenous 2-5A is detected in infected cell extracts. However, only the largest OAS isoform, OAS3, is readily detected throughout the time course of infection. While IFNb treatment results in an increase in the level of all three OAS isoforms in FRhK-4 cells, IFNb pretreatment does not affect the temporal onset or enhancement of RNase L activity nor inhibit virus replication. Our results indicate that CVB1 and HAV/18f activate the 2-5OAS/RNase L pathway in FRhK-4 cells during permissive infection through endogenous levels of OAS, but contrary to that reported for some picornaviruses, CVB1 and HAV/18f replication is insensitive to this activated antiviral pathway. JF - Virology AU - Kulka, M AU - Calvo AU - Ngo, D T AU - Wales, S Q AU - Goswami, B B AD - Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA, michael.kulka@fda.hhs.gov Y1 - 2009/05/25/ PY - 2009 DA - 2009 May 25 SP - 169 EP - 184 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 388 IS - 1 SN - 0042-6822, 0042-6822 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Coxsackievirus KW - Replication KW - ribonuclease L KW - Infection KW - A 01340:Antibiotics & Antimicrobials KW - N 14835:Protein-Nucleic Acids Association KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Activation+of+the+2-5OAS%2FRNase+L+pathway+in+CVB1+or+HAV%2F18f+infected+FRhK-4+cells+does+not+require+induction+of+OAS1+or+OAS2+expression&rft.au=Kulka%2C+M%3BCalvo%3BNgo%2C+D+T%3BWales%2C+S+Q%3BGoswami%2C+B+B&rft.aulast=Kulka&rft.aufirst=M&rft.date=2009-05-25&rft.volume=388&rft.issue=1&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2009.03.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Replication; Infection; ribonuclease L; Coxsackievirus DO - http://dx.doi.org/10.1016/j.virol.2009.03.014 ER - TY - JOUR T1 - Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles AN - 20440326; 9117907 AB - Nanoparticles are small scale substances (<100nm) used in biomedical applications, electronics, and energy production. Increased exposure to nanoparticles being produced in large-scale industry facilities elicits concerns for the toxicity of certain classes of nanoparticles. This study evaluated the effects of silver-25nm (Ag-25) nanoparticles on gene expression in different regions of the mouse brain. Adult-male C57BL/6N mice were administered (i.p.) 100mg/kg, 500mg/kg or 1000mg/kg Ag-25 and sacrificed after 24h. Regions from the brain were rapidly removed and dissected into caudate nucleus, frontal cortex and hippocampus. Total RNA was isolated from each of the three brain regions collected and real-time RT-PCR analysis was performed using Mouse Oxidative Stress and Antioxidant Defense Arrays. Array data revealed the expression of genes varied in the caudate nucleus, frontal cortex and hippocampus of mice when treated with Ag-25. The data suggest that Ag-25 nanoparticles may produce neurotoxicity by generating free radical-induced oxidative stress and by altering gene expression, producing apoptosis and neurotoxicity. JF - Toxicology Letters AU - Rahman, M F AU - Wang, J AU - Patterson, T A AU - Saini, U T AU - Robinson, B L AU - Newport, G D AU - Murdock, R C AU - Schlager, J J AU - Hussain, S M AU - Ali, S F AD - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079-9502, USA, Saber.Hussain@wpafb.af.mil Y1 - 2009/05/22/ PY - 2009 DA - 2009 May 22 SP - 15 EP - 21 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 187 IS - 1 SN - 0378-4274, 0378-4274 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Data processing KW - Antioxidants KW - Apoptosis KW - Hippocampus KW - Brain KW - Caudate nucleus KW - Cortex (frontal) KW - RNA KW - Oxidative stress KW - Neurotoxicity KW - Polymerase chain reaction KW - nanoparticles KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20440326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Expression+of+genes+related+to+oxidative+stress+in+the+mouse+brain+after+exposure+to+silver-25+nanoparticles&rft.au=Rahman%2C+M+F%3BWang%2C+J%3BPatterson%2C+T+A%3BSaini%2C+U+T%3BRobinson%2C+B+L%3BNewport%2C+G+D%3BMurdock%2C+R+C%3BSchlager%2C+J+J%3BHussain%2C+S+M%3BAli%2C+S+F&rft.aulast=Rahman&rft.aufirst=M&rft.date=2009-05-22&rft.volume=187&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2009.01.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Apoptosis; Antioxidants; Data processing; RNA; Hippocampus; Oxidative stress; Neurotoxicity; Brain; Polymerase chain reaction; Cortex (frontal); Caudate nucleus; nanoparticles DO - http://dx.doi.org/10.1016/j.toxlet.2009.01.020 ER - TY - JOUR T1 - Smoking, alcohol use, and illicit drug use reported by adolescents aged 12-17 years: United States, 1999-2004. AN - 67534382; 19634304 AB - This report presents national prevalence estimates for self-reported health risk behaviors of smoking, alcohol use, and illicit drug use by U.S. adolescents aged 12-17 years in the National Health and Nutrition Examination Surveys (NHANES). Data in this report are from 6 years (1999-2004) of NHANES, which is conducted on a complex, stratified, multistage probability sample of the civilian, noninstitutionalized U.S. population. The tables included in this report present weighted percentages and standard errors for smoking, alcohol, and illicit drug use behaviors in U.S. adolescents, by sex, race/ethnicity, education, and poverty level (when sufficient data are available). Selected highlights are presented from information included in the tables. JF - National health statistics reports AU - Fryar, Cheryl D AU - Merino, Mercy C AU - Hirsch, Rosemarie AU - Porter, Kathryn S AD - US Department of Health And Human Services, Division of Health and Nutrition Examination Surveys, Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, MD 20782, USA. Y1 - 2009/05/20/ PY - 2009 DA - 2009 May 20 SP - 1 EP - 23 IS - 15 SN - 2164-8344, 2164-8344 KW - Street Drugs KW - 0 KW - Health administration KW - Adolescent Behavior KW - Risk-Taking KW - Humans KW - Nutrition Surveys KW - Child KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Alcohol Drinking -- epidemiology KW - Smoking -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67534382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Physical+Education%2C+Recreation+and+Dance&rft.atitle=Develop+Better+Motor+Skill+Progressions+With+Gentile%27s+Taxonomy+Of+Tasks&rft.au=Adams%2C+D+L&rft.aulast=Adams&rft.aufirst=D&rft.date=1999-10-01&rft.volume=70&rft.issue=&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+Physical+Education%2C+Recreation+and+Dance&rft.issn=07303084&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-25 N1 - Date created - 2009-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Nanoparticles: Potential Health Consequences to the Pulmonary System T2 - 2009 Central Regional Meeting of the American Chemical Society (CERMACS 2009) AN - 42131384; 5152379 JF - 2009 Central Regional Meeting of the American Chemical Society (CERMACS 2009) AU - Castranova, Vincent Y1 - 2009/05/20/ PY - 2009 DA - 2009 May 20 KW - Lung KW - Nanoparticles KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42131384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2009%29&rft.atitle=Nanoparticles%3A+Potential+Health+Consequences+to+the+Pulmonary+System&rft.au=Castranova%2C+Vincent&rft.aulast=Castranova&rft.aufirst=Vincent&rft.date=2009-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://acs.confex.com/acs/cerm09/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of An HPLC-MS/MS Test Procedure to Quantify 4-Ketocyclophosphamide,Cyclophosphamide and Ifosfamide In Human Urine T2 - 2009 Central Regional Meeting of the American Chemical Society (CERMACS 2009) AN - 42126832; 5152230 JF - 2009 Central Regional Meeting of the American Chemical Society (CERMACS 2009) AU - B'Hymer, Clayton Y1 - 2009/05/20/ PY - 2009 DA - 2009 May 20 KW - Urine KW - Ifosfamide KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42126832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2009%29&rft.atitle=Development+of+An+HPLC-MS%2FMS+Test+Procedure+to+Quantify+4-Ketocyclophosphamide%2CCyclophosphamide+and+Ifosfamide+In+Human+Urine&rft.au=B%27Hymer%2C+Clayton&rft.aulast=B%27Hymer&rft.aufirst=Clayton&rft.date=2009-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://acs.confex.com/acs/cerm09/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Screening for syphilis infection in pregnant women: evidence for the U.S. Preventive Services Task Force reaffirmation recommendation statement. AN - 67265748; 19451578 AB - In 2004, the U.S. Preventive Services Task Force strongly recommended that clinicians screen all pregnant women for syphilis infection. To update the evidence on screening pregnant women for syphilis infection. MEDLINE searches from 1 January 2003 through 31 July 2008, recent systematic reviews, reference lists of retrieved articles, and expert suggestions. English-language studies were selected to answer the following 2 questions: Does screening for syphilis in pregnancy reduce the prevalence of congenital syphilis in neonates? Are there harms of screening for syphilis or harms of treatment with penicillin in pregnancy to women or neonates? Randomized, controlled trials; meta-analyses; systematic reviews; cohort studies; and ecologic studies were selected for the potential benefits question. Randomized, controlled trials; meta-analyses; systematic reviews; cohort studies; case-control studies; and large case series were selected for the potential harms question. Information on the study design, selection criteria, demographic characteristics, and clinical outcomes was extracted from each study. One study on benefits evaluated the effect before and after the implementation of a universal syphilis screening program for pregnant women and found reductions in rates of congenital syphilis. Two studies on screening accuracy for syphilis reported false-positive rates of less than 1%. One study that used a large insurance claims database reported an incidence of anaphylaxis after oral penicillin of 0.1 per 10,000 dispensings. In a study from Hungary, oral penicillin in pregnancy was not associated with orofacial clefts. This was a targeted literature search and could have missed small studies on the benefits and harms of screening for syphilis in pregnancy. We did not review evidence on interventions to improve rates of prenatal screening. New evidence from a study of universal screening supports previous evidence on the effectiveness of screening for syphilis in pregnancy to prevent congenital syphilis. Harms include testing and follow-up for false-positive test results and adverse effects from penicillin treatment. JF - Annals of internal medicine AU - Wolff, Tracy AU - Shelton, Erica AU - Sessions, Cecili AU - Miller, Therese AD - U.S. Preventive Services Task Force, Agency for Healthcare Research and Quality, Rockville, Maryland, USA. Y1 - 2009/05/19/ PY - 2009 DA - 2009 May 19 SP - 710 EP - 716 VL - 150 IS - 10 KW - Anti-Bacterial Agents KW - 0 KW - Penicillin G Benzathine KW - RIT82F58GK KW - Abridged Index Medicus KW - Index Medicus KW - Anti-Bacterial Agents -- therapeutic use KW - Evidence-Based Medicine KW - Humans KW - Anti-Bacterial Agents -- adverse effects KW - Penicillin G Benzathine -- therapeutic use KW - Infant, Newborn KW - Time Factors KW - Penicillin G Benzathine -- adverse effects KW - Female KW - Risk Assessment KW - Pregnancy KW - False Positive Reactions KW - Pregnancy Complications, Infectious -- diagnosis KW - Syphilis, Congenital -- prevention & control KW - Syphilis -- drug therapy KW - Mass Screening -- adverse effects KW - Syphilis -- diagnosis KW - Pregnancy Complications, Infectious -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67265748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Screening+for+syphilis+infection+in+pregnant+women%3A+evidence+for+the+U.S.+Preventive+Services+Task+Force+reaffirmation+recommendation+statement.&rft.au=Wolff%2C+Tracy%3BShelton%2C+Erica%3BSessions%2C+Cecili%3BMiller%2C+Therese&rft.aulast=Wolff&rft.aufirst=Tracy&rft.date=2009-05-19&rft.volume=150&rft.issue=10&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-03 N1 - Date created - 2009-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Summary For Patients In: Ann Intern Med. 2009 May 19;150(10):I-40 [19451558] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Francisella piscicida as a Surrogate Microorganism for Francisella tularensis for Use in a Caenorhabditis elegans Infection Model T2 - 109th General Meeting of the American Society for Microbiology AN - 42144877; 5151561 JF - 109th General Meeting of the American Society for Microbiology AU - Cinar, H AU - Ewing-Peeples, L AU - Hanes, D AU - Kothary, M AU - Tall, B AU - McCardell, B Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Infection KW - Microorganisms KW - Models KW - Francisella tularensis KW - Caenorhabditis elegans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42144877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Francisella+piscicida+as+a+Surrogate+Microorganism+for+Francisella+tularensis+for+Use+in+a+Caenorhabditis+elegans+Infection+Model&rft.au=Cinar%2C+H%3BEwing-Peeples%2C+L%3BHanes%2C+D%3BKothary%2C+M%3BTall%2C+B%3BMcCardell%2C+B&rft.aulast=Cinar&rft.aufirst=H&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Utilization of a Comprehensive, High Density DNA Microarray Representing over 80 Complete Genome Sequences to Interrogate the Global Genomic Diversity of Four Major Enteric Pathogenic Species T2 - 109th General Meeting of the American Society for Microbiology AN - 42144869; 5150808 JF - 109th General Meeting of the American Society for Microbiology AU - Jackson, S AU - Patel, I AU - Mammel, M AU - Barnaba, T AU - LeClerc, J Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Genomes KW - DNA microarrays KW - Genomics KW - Population density KW - Pathogens KW - Genetic diversity KW - Nucleotide sequence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42144869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Utilization+of+a+Comprehensive%2C+High+Density+DNA+Microarray+Representing+over+80+Complete+Genome+Sequences+to+Interrogate+the+Global+Genomic+Diversity+of+Four+Major+Enteric+Pathogenic+Species&rft.au=Jackson%2C+S%3BPatel%2C+I%3BMammel%2C+M%3BBarnaba%2C+T%3BLeClerc%2C+J&rft.aulast=Jackson&rft.aufirst=S&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Molecular Subtyping Method for Vibrios T2 - 109th General Meeting of the American Society for Microbiology AN - 42144261; 5150466 JF - 109th General Meeting of the American Society for Microbiology AU - Hoffmann, M AU - Feng, P AU - Brown, E AU - Keys, C AU - Monday, S AU - Fischer, M Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Vibrio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42144261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Development+of+a+Molecular+Subtyping+Method+for+Vibrios&rft.au=Hoffmann%2C+M%3BFeng%2C+P%3BBrown%2C+E%3BKeys%2C+C%3BMonday%2C+S%3BFischer%2C+M&rft.aulast=Hoffmann&rft.aufirst=M&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phylogenetic Analysis of Salmonella enterica subsp. enterica serovar Enteritidis Using Intergenic Single Nucleotide Polymorphisms T2 - 109th General Meeting of the American Society for Microbiology AN - 42143795; 5150801 JF - 109th General Meeting of the American Society for Microbiology AU - Naum, M AU - Strain, E AU - Brown, E Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Single-nucleotide polymorphism KW - Phylogenetics KW - Anadromous species KW - Nucleotides KW - Salmonella enterica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42143795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Phylogenetic+Analysis+of+Salmonella+enterica+subsp.+enterica+serovar+Enteritidis+Using+Intergenic+Single+Nucleotide+Polymorphisms&rft.au=Naum%2C+M%3BStrain%2C+E%3BBrown%2C+E&rft.aulast=Naum&rft.aufirst=M&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Genomic Diversity and Antimicrobial Resistome of Cronobacter Species (formerly Enterobacter sakazakii) Using a Novel High Density Genome Array T2 - 109th General Meeting of the American Society for Microbiology AN - 42143230; 5150804 JF - 109th General Meeting of the American Society for Microbiology AU - Patel, I AU - Jackson, S AU - Harbottle, H AU - Mammel, M AU - Hu, L. AU - Curtis, S AU - McCardell, B AU - Kim, J AU - Tall, B Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Antimicrobial agents KW - Genomes KW - Genomics KW - Population density KW - Genetic diversity KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42143230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Characterization+of+the+Genomic+Diversity+and+Antimicrobial+Resistome+of+Cronobacter+Species+%28formerly+Enterobacter+sakazakii%29+Using+a+Novel+High+Density+Genome+Array&rft.au=Patel%2C+I%3BJackson%2C+S%3BHarbottle%2C+H%3BMammel%2C+M%3BHu%2C+L.%3BCurtis%2C+S%3BMcCardell%2C+B%3BKim%2C+J%3BTall%2C+B&rft.aulast=Patel&rft.aufirst=I&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identifying Single Nucleotide Polymorphisms (SNPs) in Various Salmonella Serotypes Using a Novel DNA Tiling Microarray T2 - 109th General Meeting of the American Society for Microbiology AN - 42142993; 5151180 JF - 109th General Meeting of the American Society for Microbiology AU - Gangiredla, J AU - Lewis, J AU - Mammel, M AU - Patel, I AU - LeClerc, J AU - Jackson, S Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Single-nucleotide polymorphism KW - DNA microarrays KW - Serotypes KW - Anadromous species KW - Nucleotides KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42142993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Identifying+Single+Nucleotide+Polymorphisms+%28SNPs%29+in+Various+Salmonella+Serotypes+Using+a+Novel+DNA+Tiling+Microarray&rft.au=Gangiredla%2C+J%3BLewis%2C+J%3BMammel%2C+M%3BPatel%2C+I%3BLeClerc%2C+J%3BJackson%2C+S&rft.aulast=Gangiredla&rft.aufirst=J&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extensive Genomic Plasticity of Escherichia coli O157:H7 Revealed by Optical Mapping T2 - 109th General Meeting of the American Society for Microbiology AN - 42142812; 5150796 JF - 109th General Meeting of the American Society for Microbiology AU - Lacher, D AU - Kotewicz, M AU - Mammel, M AU - Whittam, T Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Gene mapping KW - Plasticity KW - Genomics KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42142812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Extensive+Genomic+Plasticity+of+Escherichia+coli+O157%3AH7+Revealed+by+Optical+Mapping&rft.au=Lacher%2C+D%3BKotewicz%2C+M%3BMammel%2C+M%3BWhittam%2C+T&rft.aulast=Lacher&rft.aufirst=D&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lysis of Erythrocytes by Cronobacter spp. (formerly Enterobacter sakazakii) Is Caused by pH and not by Hemolysins T2 - 109th General Meeting of the American Society for Microbiology AN - 42141148; 5151120 JF - 109th General Meeting of the American Society for Microbiology AU - Kothary, M AU - Everton, K AU - McCardell, B AU - Tall, B Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Erythrocytes KW - PH KW - Hemolysins KW - PH effects KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42141148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Lysis+of+Erythrocytes+by+Cronobacter+spp.+%28formerly+Enterobacter+sakazakii%29+Is+Caused+by+pH+and+not+by+Hemolysins&rft.au=Kothary%2C+M%3BEverton%2C+K%3BMcCardell%2C+B%3BTall%2C+B&rft.aulast=Kothary&rft.aufirst=M&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Lipopolysaccharide O Antigen Chain Length/Synthesis in Salmonella enterica Serovars Typhi and Paratyphi A Is Influenced by using Heterologous wzz Gene Products T2 - 109th General Meeting of the American Society for Microbiology AN - 42140672; 5151078 JF - 109th General Meeting of the American Society for Microbiology AU - Xu, D. AU - Kopecko, D AU - Robbins, J AU - Szu, S AU - Schneerson, R Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Lipopolysaccharides KW - O antigen KW - Anadromous species KW - Antigens KW - Gene products KW - Paratyphis KW - Salmonella enterica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42140672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Regulation+of+Lipopolysaccharide+O+Antigen+Chain+Length%2FSynthesis+in+Salmonella+enterica+Serovars+Typhi+and+Paratyphi+A+Is+Influenced+by+using+Heterologous+wzz+Gene+Products&rft.au=Xu%2C+D.%3BKopecko%2C+D%3BRobbins%2C+J%3BSzu%2C+S%3BSchneerson%2C+R&rft.aulast=Xu&rft.aufirst=D.&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Substrate Specificity and Structural Characteristics of the Novel Rieske Non-Heme Iron Aromatic Ring-Hydroxylating Oxygenases NidAB and NidA3B3 from Mycobacterium vanbaalenii PYR-1 T2 - 109th General Meeting of the American Society for Microbiology AN - 42133438; 5151609 JF - 109th General Meeting of the American Society for Microbiology AU - Kweon, O AU - Kim, S-J AU - Freeman, J AU - Song, J AU - Baek, S AU - Cerniglia, C Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Iron KW - Oxygenase KW - Aromatics KW - Substrate specificity KW - Specificity KW - Mycobacterium vanbaalenii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42133438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Substrate+Specificity+and+Structural+Characteristics+of+the+Novel+Rieske+Non-Heme+Iron+Aromatic+Ring-Hydroxylating+Oxygenases+NidAB+and+NidA3B3+from+Mycobacterium+vanbaalenii+PYR-1&rft.au=Kweon%2C+O%3BKim%2C+S-J%3BFreeman%2C+J%3BSong%2C+J%3BBaek%2C+S%3BCerniglia%2C+C&rft.aulast=Kweon&rft.aufirst=O&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Degradation of Sudan III by Staphylococcus aureus and Its Toxicity to Bacterial Cells T2 - 109th General Meeting of the American Society for Microbiology AN - 42132085; 5151606 JF - 109th General Meeting of the American Society for Microbiology AU - Zou, W AU - Heinze, T AU - Cerniglia, C AU - Chen, H Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Sudan KW - Toxicity KW - Degradation KW - Staphylococcus aureus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42132085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Degradation+of+Sudan+III+by+Staphylococcus+aureus+and+Its+Toxicity+to+Bacterial+Cells&rft.au=Zou%2C+W%3BHeinze%2C+T%3BCerniglia%2C+C%3BChen%2C+H&rft.aulast=Zou&rft.aufirst=W&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigating Two Putative Virulence Plasmids in Cronobacter spp. (Formerly Enterobacter sakazakii) and the Development of a PCR Assay T2 - 109th General Meeting of the American Society for Microbiology AN - 42124441; 5150380 JF - 109th General Meeting of the American Society for Microbiology AU - Hu, L. AU - Sathyamoorthy, V AU - Kim, J AU - Sadowski, J AU - Tall, B Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Virulence KW - Polymerase chain reaction KW - Plasmids KW - Nucleotide sequence KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42124441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Investigating+Two+Putative+Virulence+Plasmids+in+Cronobacter+spp.+%28Formerly+Enterobacter+sakazakii%29+and+the+Development+of+a+PCR+Assay&rft.au=Hu%2C+L.%3BSathyamoorthy%2C+V%3BKim%2C+J%3BSadowski%2C+J%3BTall%2C+B&rft.aulast=Hu&rft.aufirst=L.&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effective Intervention to Reduce Carriage of Salmonella Newport on Tomatoes by Naturally-occurring Epiphytic Bacilli T2 - 109th General Meeting of the American Society for Microbiology AN - 42123976; 5150015 JF - 109th General Meeting of the American Society for Microbiology AU - Zheng, J AU - Enurah, A AU - Ramaseshan, A AU - Brown, E Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Intervention KW - Bacilli KW - Anadromous species KW - Lycopersicon esculentum KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42123976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Effective+Intervention+to+Reduce+Carriage+of+Salmonella+Newport+on+Tomatoes+by+Naturally-occurring+Epiphytic+Bacilli&rft.au=Zheng%2C+J%3BEnurah%2C+A%3BRamaseshan%2C+A%3BBrown%2C+E&rft.aulast=Zheng&rft.aufirst=J&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Himar1-based Transposon Mutagenesis of Bacillus anthracis T2 - 109th General Meeting of the American Society for Microbiology AN - 42123810; 5150459 JF - 109th General Meeting of the American Society for Microbiology AU - Plaut, R AU - Stibitz, S Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Transposon mutagenesis KW - Mutagenesis KW - Bacillus anthracis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42123810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Himar1-based+Transposon+Mutagenesis+of+Bacillus+anthracis&rft.au=Plaut%2C+R%3BStibitz%2C+S&rft.aulast=Plaut&rft.aufirst=R&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GPI-anchored Proteins and a Specific Glycan on Flagellin Play Key Roles in Campylobacter jejuni 81-176 Adherence to and Invasion of Human Epithelial Cells T2 - 109th General Meeting of the American Society for Microbiology AN - 42123432; 5150561 JF - 109th General Meeting of the American Society for Microbiology AU - Shima, K AU - Fukunaga, H AU - Kopecko, D AU - Guerry, P AU - Ewing, C AU - Giri, C Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Flagellin KW - Epithelial cells KW - Polysaccharides KW - Introduced species KW - Campylobacter jejuni KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42123432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=GPI-anchored+Proteins+and+a+Specific+Glycan+on+Flagellin+Play+Key+Roles+in+Campylobacter+jejuni+81-176+Adherence+to+and+Invasion+of+Human+Epithelial+Cells&rft.au=Shima%2C+K%3BFukunaga%2C+H%3BKopecko%2C+D%3BGuerry%2C+P%3BEwing%2C+C%3BGiri%2C+C&rft.aulast=Shima&rft.aufirst=K&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the Hydrophobic Grid Membrane Filter for the Enumeration of Moulds and Yeasts in Naturally-Contaminated Foods T2 - 109th General Meeting of the American Society for Microbiology AN - 42122846; 5150485 JF - 109th General Meeting of the American Society for Microbiology AU - Tournas, V AU - Katsoudas, E Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Filters KW - Membranes KW - Hydrophobicity KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42122846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Evaluation+of+the+Hydrophobic+Grid+Membrane+Filter+for+the+Enumeration+of+Moulds+and+Yeasts+in+Naturally-Contaminated+Foods&rft.au=Tournas%2C+V%3BKatsoudas%2C+E&rft.aulast=Tournas&rft.aufirst=V&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enterobacter sakazakii Transcytose Cultured Human Intestinal Epithelial Cells and Translocate across Human Brain Microvascular Endothelial Cells - Molecular Mechanisms for CNS Involvement T2 - 109th General Meeting of the American Society for Microbiology AN - 42122705; 5150543 JF - 109th General Meeting of the American Society for Microbiology AU - Giri, C AU - Shima, K AU - Hanisch, B AU - Kopecko, D AU - Tall, B AU - Curtiss, S AU - Kim, K Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Intestine KW - Microvasculature KW - Epithelial cells KW - Central nervous system KW - Molecular modelling KW - Endothelial cells KW - Brain KW - Enterobacter sakazakii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42122705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Enterobacter+sakazakii+Transcytose+Cultured+Human+Intestinal+Epithelial+Cells+and+Translocate+across+Human+Brain+Microvascular+Endothelial+Cells+-+Molecular+Mechanisms+for+CNS+Involvement&rft.au=Giri%2C+C%3BShima%2C+K%3BHanisch%2C+B%3BKopecko%2C+D%3BTall%2C+B%3BCurtiss%2C+S%3BKim%2C+K&rft.aulast=Giri&rft.aufirst=C&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Joint FDA/Health Canada Risk Assessment: Listeria monocytogenes in Soft-Ripened Cheese T2 - 109th General Meeting of the American Society for Microbiology AN - 42122613; 5150078 JF - 109th General Meeting of the American Society for Microbiology AU - Gendel, S AU - Pouillot, R AU - Murray III, C. Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Canada KW - Dairy products KW - Risk assessment KW - Food contamination KW - FDA KW - Cheese KW - Joints KW - Listeria monocytogenes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42122613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Joint+FDA%2FHealth+Canada+Risk+Assessment%3A+Listeria+monocytogenes+in+Soft-Ripened+Cheese&rft.au=Gendel%2C+S%3BPouillot%2C+R%3BMurray+III%2C+C.&rft.aulast=Gendel&rft.aufirst=S&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Survival of Hepatitis A Virus in Fresh Vegetable during Cold Storage T2 - 109th General Meeting of the American Society for Microbiology AN - 42122576; 5150075 JF - 109th General Meeting of the American Society for Microbiology AU - Shieh, Y AU - Laird, D AU - Tortorello, M Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Storage KW - Survival KW - Hepatitis A KW - Vegetables KW - Cold storage KW - Hepatitis A virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42122576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Survival+of+Hepatitis+A+Virus+in+Fresh+Vegetable+during+Cold+Storage&rft.au=Shieh%2C+Y%3BLaird%2C+D%3BTortorello%2C+M&rft.aulast=Shieh&rft.aufirst=Y&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Characterization of Fluoroquinolone-resistant Genes in Virulent Strains of Pseudomonas spp. Isolated from Imported Shrimp T2 - 109th General Meeting of the American Society for Microbiology AN - 42122537; 5150382 JF - 109th General Meeting of the American Society for Microbiology AU - Tran, Q AU - Nawaz, M AU - Khan, S AU - Khan, A AU - Sung, K AU - Cerniglia, C Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Strains KW - Pseudomonas KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42122537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Molecular+Characterization+of+Fluoroquinolone-resistant+Genes+in+Virulent+Strains+of+Pseudomonas+spp.+Isolated+from+Imported+Shrimp&rft.au=Tran%2C+Q%3BNawaz%2C+M%3BKhan%2C+S%3BKhan%2C+A%3BSung%2C+K%3BCerniglia%2C+C&rft.aulast=Tran&rft.aufirst=Q&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Analysis for the Absence of O157 Antigen Expression in MA6, a Shigatoxigenic Escherichia coli O rough:H7 strain T2 - 109th General Meeting of the American Society for Microbiology AN - 42122522; 5150068 JF - 109th General Meeting of the American Society for Microbiology AU - Rump, L AU - Feng, P AU - Monday, S AU - Fischer, M Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Genetic analysis KW - Antigens KW - Strains KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42122522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Genetic+Analysis+for+the+Absence+of+O157+Antigen+Expression+in+MA6%2C+a+Shigatoxigenic+Escherichia+coli+O+rough%3AH7+strain&rft.au=Rump%2C+L%3BFeng%2C+P%3BMonday%2C+S%3BFischer%2C+M&rft.aulast=Rump&rft.aufirst=L&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Live Salmonella spp. Cells in Produce by a TaqMan Based Quantitative Reverse Transcriptase Real Time PCR (QRT-qPCR) Targeting invA mRNA T2 - 109th General Meeting of the American Society for Microbiology AN - 42122136; 5150465 JF - 109th General Meeting of the American Society for Microbiology AU - Gonzalez-Escalona, N AU - Hammack, T AU - Russell, M AU - Jacobson, A AU - De Jesus, A AU - Brown, E AU - Lampel, K Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - RNA-directed DNA polymerase KW - Polymerase chain reaction KW - Anadromous species KW - Nucleotide sequence KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42122136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Detection+of+Live+Salmonella+spp.+Cells+in+Produce+by+a+TaqMan+Based+Quantitative+Reverse+Transcriptase+Real+Time+PCR+%28QRT-qPCR%29+Targeting+invA+mRNA&rft.au=Gonzalez-Escalona%2C+N%3BHammack%2C+T%3BRussell%2C+M%3BJacobson%2C+A%3BDe+Jesus%2C+A%3BBrown%2C+E%3BLampel%2C+K&rft.aulast=Gonzalez-Escalona&rft.aufirst=N&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acid Resistance of E. coli O157:H7 as Determined by Exposure to pH2 T2 - 109th General Meeting of the American Society for Microbiology AN - 42121283; 5150477 JF - 109th General Meeting of the American Society for Microbiology AU - Yoshitomi, K AU - Jinneman, K AU - Weagant, S AU - Zapata, R AU - Strietelmeier, B AU - Fedio, W Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42121283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Acid+Resistance+of+E.+coli+O157%3AH7+as+Determined+by+Exposure+to+pH2&rft.au=Yoshitomi%2C+K%3BJinneman%2C+K%3BWeagant%2C+S%3BZapata%2C+R%3BStrietelmeier%2C+B%3BFedio%2C+W&rft.aulast=Yoshitomi&rft.aufirst=K&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of 131 Multiple Antibiotic Resistant Markers in Foodborne and Clinical Pathogens using PCR Assay T2 - 109th General Meeting of the American Society for Microbiology AN - 42120431; 5149889 JF - 109th General Meeting of the American Society for Microbiology AU - Sung, K AU - Khan, S AU - Nawaz, M Y1 - 2009/05/17/ PY - 2009 DA - 2009 May 17 KW - Antibiotics KW - Pathogens KW - Polymerase chain reaction KW - Food KW - Nucleotide sequence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42120431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Detection+of+131+Multiple+Antibiotic+Resistant+Markers+in+Foodborne+and+Clinical+Pathogens+using+PCR+Assay&rft.au=Sung%2C+K%3BKhan%2C+S%3BNawaz%2C+M&rft.aulast=Sung&rft.aufirst=K&rft.date=2009-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network. AN - 67165523; 19251246 AB - Hypocretin (Hcrt), an arousal- and feeding-associated peptide, is expressed in lateral hypothalamic neurons that project to the ventral tegmental area (VTA). Intra-VTA Hcrt reinstates morphine-conditioned place preferences, and intracerebroventricular and intra-VTA corticotropin-releasing factor (CRF) reinstate cocaine seeking. Each is presumed to act, at least in part, through actions local to the VTA. Here, we examined the possibility that VTA perfusion of Hcrt reinstates cocaine seeking and, if so, whether it does so through the VTA mechanism that is implicated in reinstatement by CRF. Rats were trained to lever-press for intravenous cocaine (2 weeks) and then underwent extinction training (saline substituted for cocaine: 3 weeks). Reinstatement behavior was tested and VTA dialysates were collected and assayed for glutamate or dopamine following footshock or perfusion of Hcrt or CRF, with or without Hcrt or CRF antagonists, into the VTA. Ventral tegmental area perfusion of Hcrt-1 or footshock stress reinstated cocaine seeking and caused release of VTA glutamate and dopamine. The effects of Hcrt-1 were blocked by a selective Hcrt-1 antagonist, but not a CRF antagonist, and were not mimicked by Hcrt-2. The Hcrt-1 antagonist did not block CRF-dependent footshock-induced reinstatement or glutamate or dopamine release. The behavioral and neurochemical effects of Hcrt-1 were attenuated but not blocked by kynurenic acid, an ionotropic glutamate antagonist that blocks footshock-induced reinstatement and glutamate release. While Hcrt and CRF are known to interact in some area of the brain, in the VTA proper they appear to have largely independent actions on the mesolimbic dopamine mechanisms of cocaine seeking. JF - Biological psychiatry AU - Wang, Bin AU - You, Zhi-Bing AU - Wise, Roy A AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2009/05/15/ PY - 2009 DA - 2009 May 15 SP - 857 EP - 862 VL - 65 IS - 10 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - Neuropeptides KW - Orexin Receptors KW - Orexins KW - Phenylurea Compounds KW - Receptors, Corticotropin-Releasing Hormone KW - Receptors, G-Protein-Coupled KW - Receptors, Kainic Acid KW - Receptors, Neuropeptide KW - SB 408124 KW - Glutamic Acid KW - 3KX376GY7L KW - Kynurenic Acid KW - H030S2S85J KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Drug Interactions KW - Rats, Long-Evans KW - Glutamic Acid -- metabolism KW - Receptors, Neuropeptide -- antagonists & inhibitors KW - Dopamine -- metabolism KW - Kynurenic Acid -- pharmacology KW - Rats KW - Receptors, G-Protein-Coupled -- antagonists & inhibitors KW - Self Administration KW - Kynurenic Acid -- administration & dosage KW - Phenylurea Compounds -- antagonists & inhibitors KW - Receptors, Kainic Acid -- antagonists & inhibitors KW - Electroshock KW - Male KW - Neuropeptides -- pharmacology KW - Neuropeptides -- administration & dosage KW - Ventral Tegmental Area -- metabolism KW - Receptors, Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Intracellular Signaling Peptides and Proteins -- pharmacology KW - Ventral Tegmental Area -- drug effects KW - Cocaine -- pharmacology KW - Cocaine -- administration & dosage KW - Intracellular Signaling Peptides and Proteins -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67165523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Reinstatement+of+cocaine+seeking+by+hypocretin+%28orexin%29+in+the+ventral+tegmental+area%3A+independence+from+the+local+corticotropin-releasing+factor+network.&rft.au=Wang%2C+Bin%3BYou%2C+Zhi-Bing%3BWise%2C+Roy+A&rft.aulast=Wang&rft.aufirst=Bin&rft.date=2009-05-15&rft.volume=65&rft.issue=10&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=1873-2402&rft_id=info:doi/10.1016%2Fj.biopsych.2009.01.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-30 N1 - Date created - 2009-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuropsychopharmacology. 2006 Feb;31(2):384-95 [15988471] J Neurosci. 2006 Jan 11;26(2):398-405 [16407535] J Pharmacol Exp Ther. 2006 Apr;317(1):163-71 [16352704] Anesthesiology. 2006 May;104(5):1023-32 [16645455] Neuroscience. 2006 Sep 1;141(3):1101-5 [16820265] Eur J Neurosci. 2007 Mar;25(5):1537-45 [17425580] J Comp Neurol. 2007 Aug 10;503(5):668-84 [17559101] Psychopharmacology (Berl). 2007 Aug;193(2):283-94 [17437087] J Neurosci. 2007 Sep 26;27(39):10546-55 [17898226] Physiol Behav. 2008 Mar 18;93(4-5):947-51 [18262574] J Neurosci. 2008 Sep 3;28(36):9021-9 [18768696] J Neurosci. 2000 Feb 15;20(4):1635-42 [10662853] Peptides. 1999 Dec;20(12):1455-70 [10698122] Br J Pharmacol. 2000 Apr;129(7):1289-91 [10742282] J Comp Neurol. 2001 Jun 18;435(1):6-25 [11370008] Neurosci Lett. 2002 Apr 26;323(2):93-6 [11950501] Nat Rev Neurosci. 2002 May;3(5):339-49 [11988773] Annu Rev Neurosci. 2002;25:283-313 [12052911] J Neurosci. 2003 Jan 1;23(1):7-11 [12514194] Annu Rev Psychol. 1989;40:191-225 [2648975] Psychopharmacology (Berl). 1996 Jun;125(4):385-91 [8826544] Annu Rev Neurosci. 1996;19:319-40 [8833446] Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):322-7 [9419374] Cell. 1998 Feb 20;92(4):573-85 [9491897] J Neurosci. 1998 Dec 1;18(23):9996-10015 [9822755] Synapse. 1999 Mar 15;31(4):241-9 [10051104] Br J Pharmacol. 1999 Sep;128(1):1-3 [10498827] J Neurosci. 2005 Jun 1;25(22):5389-96 [15930388] Nature. 2005 Sep 22;437(7058):556-9 [16100511] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19168-73 [16357203] Neuron. 2006 Feb 16;49(4):589-601 [16476667] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.biopsych.2009.01.018 ER - TY - RPRT T1 - TRANSPORT OF LABORATORY PERSONNEL POTENTIALLY EXPOSED TO INFECTIOUS AGENTS FROM FORT DETRICK, FREDERICK, MARYLAND TO THE NATIONAL INSTITUTES OF HEALTH CLINICAL CENTER, BETHESDA, MARYLAND. [Part 1 of 1] T2 - TRANSPORT OF LABORATORY PERSONNEL POTENTIALLY EXPOSED TO INFECTIOUS AGENTS FROM FORT DETRICK, FREDERICK, MARYLAND TO THE NATIONAL INSTITUTES OF HEALTH CLINICAL CENTER, BETHESDA, MARYLAND. AN - 756825050; 13880-090156_0001 AB - PURPOSE: The transport of any laboratory personnel suspected of having potential occupational exposure to infectious agents under study at the National Interagency Biodefense Campus (NIBC), located at Fort Detrick, Maryland, to the Special Clinical Studies Unit at the National Institutes of Health (NIH) Bethesda, Maryland Campus is proposed. The NIH Bethesda campus is inside the Capital Beltway (Interstate 495) along the northern boundary of the Bethesda Central Business District in Montgomery County. Fort Detrick is a U.S. Army Medical Command Installation located on 1,200 acres in Frederick. The National Institute of Allergy and Infectious Disease (NIAID), a component of the NIH, will occupy an integrated research facility (IRF) currently being built at Fort Detrick as part of the NIBC. The IRF will contain specially designed laboratories and animal research facilities for conducting biodefense and emerging infectious disease research. Key issues identified during scoping include those related to community safety, security during transport, accident risk, and coordination of accident response. Alternatives analyzed in this draft EIS include a No Action Alternative and the Proposed Action. Under the Proposed Action, which is also the currently preferred alternative, laboratory personnel potentially exposed to infectious agents under study at the NIBC would be transported to the NIH Special Clinical Studies Unit in Bethesda for monitoring, observation and treatment. Transport would use a government-owned vehicle and could entail escort by one or more, regular police patrol vehicles over interstate and local roads. The most direct transportation route by motor vehicle would include Interstate 270 and Interstate 495. Prior to departing Fort Detrick, ambulance and law enforcement personnel would determine the appropriate route based upon roadway conditions, traffic volume, and other factors. Local police would coordinate resources, initiate notification procedures, and determine escort requirements. In the event of a motor vehicle accident involving the ambulance, first responders from local emergency service organizations would utilize existing procedures, protocols, and protective equipment to manage the incident. Special features of the NIH transport vehicle would make dispersion of infectious agents from the potentially infected laboratory personnel highly unlikely. POSITIVE IMPACTS: The proposed action would allow NIAID to achieve its research goals while ensuring that NIAID employees conducting research at the new IRF at Fort Detrick would receive appropriate medical evaluation and treatment in the event of any potential occupational exposure to infectious agents. NEGATIVE IMPACTS: Implementation of the proposed action involves risks inherent to the delivery of emergency services, including the operation of vehicles and the potential for exposure to pathogens. However, many of these risks are mitigated by the adoption of policies and procedures that are reinforced through training and oversight. JF - EPA number: 090156, 188 pages, May 12, 2009 PY - 2009 VL - 1 KW - Hazardous Substances KW - Biological Agents KW - Health Hazards KW - Health Hazards Analyses KW - Highways KW - Military Facilities (Army) KW - Motor Vehicles KW - Research KW - Research Facilities KW - Roads KW - Safety KW - Transportation KW - Fort Detrick KW - Maryland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756825050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=TRANSPORT+OF+LABORATORY+PERSONNEL+POTENTIALLY+EXPOSED+TO+INFECTIOUS+AGENTS+FROM+FORT+DETRICK%2C+FREDERICK%2C+MARYLAND+TO+THE+NATIONAL+INSTITUTES+OF+HEALTH+CLINICAL+CENTER%2C+BETHESDA%2C+MARYLAND.&rft.title=TRANSPORT+OF+LABORATORY+PERSONNEL+POTENTIALLY+EXPOSED+TO+INFECTIOUS+AGENTS+FROM+FORT+DETRICK%2C+FREDERICK%2C+MARYLAND+TO+THE+NATIONAL+INSTITUTES+OF+HEALTH+CLINICAL+CENTER%2C+BETHESDA%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2009-07-16 N1 - SuppNotes - Draft. Preparation date: May 12, 2009 N1 - Last updated - 2011-12-16 ER - TY - CPAPER T1 - Exploring the Emergency Preparedness Competencies of Disaster Healthcare Responders During Hurricanes Katrina and Rita T2 - 16th World Congress on Disaster and Emergency Medicine (WCDEM 2009) AN - 42135858; 5155086 JF - 16th World Congress on Disaster and Emergency Medicine (WCDEM 2009) AU - Slepski, L Y1 - 2009/05/12/ PY - 2009 DA - 2009 May 12 KW - Emergency preparedness KW - Hurricanes KW - Disasters KW - Health care KW - Emergencies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42135858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+World+Congress+on+Disaster+and+Emergency+Medicine+%28WCDEM+2009%29&rft.atitle=Exploring+the+Emergency+Preparedness+Competencies+of+Disaster+Healthcare+Responders+During+Hurricanes+Katrina+and+Rita&rft.au=Slepski%2C+L&rft.aulast=Slepski&rft.aufirst=L&rft.date=2009-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+World+Congress+on+Disaster+and+Emergency+Medicine+%28WCDEM+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.wcdem2009.org/index.php?option=com_content&task=view&id=29& Itemid=62 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - RPRT T1 - TRANSPORT OF LABORATORY PERSONNEL POTENTIALLY EXPOSED TO INFECTIOUS AGENTS FROM FORT DETRICK, FREDERICK, MARYLAND TO THE NATIONAL INSTITUTES OF HEALTH CLINICAL CENTER, BETHESDA, MARYLAND. AN - 36346028; 13880 AB - PURPOSE: The transport of any laboratory personnel suspected of having potential occupational exposure to infectious agents under study at the National Interagency Biodefense Campus (NIBC), located at Fort Detrick, Maryland, to the Special Clinical Studies Unit at the National Institutes of Health (NIH) Bethesda, Maryland Campus is proposed. The NIH Bethesda campus is inside the Capital Beltway (Interstate 495) along the northern boundary of the Bethesda Central Business District in Montgomery County. Fort Detrick is a U.S. Army Medical Command Installation located on 1,200 acres in Frederick. The National Institute of Allergy and Infectious Disease (NIAID), a component of the NIH, will occupy an integrated research facility (IRF) currently being built at Fort Detrick as part of the NIBC. The IRF will contain specially designed laboratories and animal research facilities for conducting biodefense and emerging infectious disease research. Key issues identified during scoping include those related to community safety, security during transport, accident risk, and coordination of accident response. Alternatives analyzed in this draft EIS include a No Action Alternative and the Proposed Action. Under the Proposed Action, which is also the currently preferred alternative, laboratory personnel potentially exposed to infectious agents under study at the NIBC would be transported to the NIH Special Clinical Studies Unit in Bethesda for monitoring, observation and treatment. Transport would use a government-owned vehicle and could entail escort by one or more, regular police patrol vehicles over interstate and local roads. The most direct transportation route by motor vehicle would include Interstate 270 and Interstate 495. Prior to departing Fort Detrick, ambulance and law enforcement personnel would determine the appropriate route based upon roadway conditions, traffic volume, and other factors. Local police would coordinate resources, initiate notification procedures, and determine escort requirements. In the event of a motor vehicle accident involving the ambulance, first responders from local emergency service organizations would utilize existing procedures, protocols, and protective equipment to manage the incident. Special features of the NIH transport vehicle would make dispersion of infectious agents from the potentially infected laboratory personnel highly unlikely. POSITIVE IMPACTS: The proposed action would allow NIAID to achieve its research goals while ensuring that NIAID employees conducting research at the new IRF at Fort Detrick would receive appropriate medical evaluation and treatment in the event of any potential occupational exposure to infectious agents. NEGATIVE IMPACTS: Implementation of the proposed action involves risks inherent to the delivery of emergency services, including the operation of vehicles and the potential for exposure to pathogens. However, many of these risks are mitigated by the adoption of policies and procedures that are reinforced through training and oversight. JF - EPA number: 090156, 188 pages, May 12, 2009 PY - 2009 KW - Hazardous Substances KW - Biological Agents KW - Health Hazards KW - Health Hazards Analyses KW - Highways KW - Military Facilities (Army) KW - Motor Vehicles KW - Research KW - Research Facilities KW - Roads KW - Safety KW - Transportation KW - Fort Detrick KW - Maryland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36346028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=Chris&rft.date=2006-11-13&rft.volume=105&rft.issue=19&rft.spage=Z.20&rft.isbn=&rft.btitle=&rft.title=Sports+Illustrated&rft.issn=0038822X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2009-07-16 N1 - SuppNotes - Draft. Preparation date: May 12, 2009 N1 - Last updated - 2011-12-16 ER - TY - CPAPER T1 - Reconciling Bayesian and Frequentist Hypotheses Testing in Clinical Trials with Dichotomous and Countable Outcomes T2 - 5th Conference of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2009) AN - 41750845; 5027252 JF - 5th Conference of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2009) AU - Zaslavsky, B Y1 - 2009/05/10/ PY - 2009 DA - 2009 May 10 KW - Clinical trials KW - Bayesian analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41750845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Conference+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2009%29&rft.atitle=Reconciling+Bayesian+and+Frequentist+Hypotheses+Testing+in+Clinical+Trials+with+Dichotomous+and+Countable+Outcomes&rft.au=Zaslavsky%2C+B&rft.aulast=Zaslavsky&rft.aufirst=B&rft.date=2009-05-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Conference+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibs-emr2009.com/sci_prog.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risk Calculations in Detection of Microbial and DNA Contamination: Bernoulli Model T2 - 5th Conference of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2009) AN - 41747041; 5027076 JF - 5th Conference of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2009) AU - Sirota, L Y1 - 2009/05/10/ PY - 2009 DA - 2009 May 10 KW - Contamination KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41747041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Conference+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2009%29&rft.atitle=Risk+Calculations+in+Detection+of+Microbial+and+DNA+Contamination%3A+Bernoulli+Model&rft.au=Sirota%2C+L&rft.aulast=Sirota&rft.aufirst=L&rft.date=2009-05-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Conference+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibs-emr2009.com/sci_prog.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Induction of Metallothionein I by Arsenic via Metal-activated Transcription Factor 1: CRITICAL ROLE OF C-TERMINAL CYSTEINE RESIDUES IN ARSENIC SENSING AN - 21092938; 11079333 AB - Metal-activated transcription factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals. The mechanism of MTF1 activation has not been well understood. We analyzed the interaction between arsenic (As super(3+)) and MTF1 for Mt1 induction. As super(3+) potently induces Mt1 mRNA expression in mouse hepa1c1c7 cells. Induction is dependent upon functional MTF1 as induction is lost in Mtf1 knockout cells but is restored upon reconstitution with Mtf1; moreover, As super(3+) induces the binding of MTF1 to the metal response elements of endogenous Mt1. Induction is not affected by modulating zinc concentrations but is markedly enhanced by cycloheximide. Phenylarsine oxide (PAO), which covalently binds to vicinal protein cysteine thiol groups, induces Mt1 with a magnitude of higher potency than that of As super(3+). PAO affinity beads effectively pulls down the carboxyl half of MTF1 (MTF1 sub(321-675)) by binding to a cluster of five cysteine residues near the terminus. Preincubation with As super(3+), Cd super(2+), Co super(2+), Ni super(2+), Ag super(+), Hg super(2+), and Bi super(3+) blocks pulldown of MTF1 sub(321-675) by PAO beads in vitro and in vivo, indicating that binding of the metal inducers to the same C- terminal cysteine cluster as PAO occurs. Deletion of the C-terminal cysteine cluster or mutation of the cysteine residues abolishes or markedly reduces the transcription activation activity of MTF1 and the ability of MTF1 to restore Mt1 induction in Mtf1 knockout cells. The findings demonstrate a critical role of the C-terminal cysteine cluster of MTF1 in arsenic sensing and gene transcription via arsenic- cysteine thiol interaction. JF - Journal of Biological Chemistry AU - He, Xiaoqing AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention Y1 - 2009/05/08/ PY - 2009 DA - 2009 May 08 SP - 12609 EP - 12621 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 284 IS - 19 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Arsenic KW - Cycloheximide KW - Cysteine KW - Gene deletion KW - Gene expression KW - Heavy metals KW - Metallothionein KW - Mutation KW - Regulatory sequences KW - Stress KW - Thiols KW - Transcription KW - Transcription factors KW - Zinc KW - oxides KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21092938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Induction+of+Metallothionein+I+by+Arsenic+via+Metal-activated+Transcription+Factor+1%3A+CRITICAL+ROLE+OF+C-TERMINAL+CYSTEINE+RESIDUES+IN+ARSENIC+SENSING&rft.au=He%2C+Xiaoqing%3BMa%2C+Qiang&rft.aulast=He&rft.aufirst=Xiaoqing&rft.date=2009-05-08&rft.volume=284&rft.issue=19&rft.spage=12609&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M901204200 L2 - http://www.jbc.org/cgi/reprint/284/19/12609.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Arsenic; Metallothionein; Heavy metals; Regulatory sequences; Cycloheximide; Transcription; Stress; Gene expression; Gene deletion; Cysteine; Transcription factors; Zinc; Thiols; oxides; Mutation DO - http://dx.doi.org/10.1074/jbc.M901204200 ER - TY - CPAPER T1 - Does State Level Adoption of Performance-Based Contracting Lead to Substance Abuse Agency Improvements in Client Engagement, Retention, and Completion of Treatment? T2 - 60th Annual Meeting New England Political Science Association AN - 41788766; 5045946 JF - 60th Annual Meeting New England Political Science Association AU - Brucker, Debra Y1 - 2009/05/07/ PY - 2009 DA - 2009 May 07 KW - Substance abuse KW - Drug abuse KW - Adoption KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41788766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Annual+Meeting+New+England+Political+Science+Association&rft.atitle=Does+State+Level+Adoption+of+Performance-Based+Contracting+Lead+to+Substance+Abuse+Agency+Improvements+in+Client+Engagement%2C+Retention%2C+and+Completion+of+Treatment%3F&rft.au=Brucker%2C+Debra&rft.aulast=Brucker&rft.aufirst=Debra&rft.date=2009-05-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Annual+Meeting+New+England+Political+Science+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.northeastern.edu/nepsa/documents/NEPSA_2009_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Surface Water Diversion and Treatment Facility Project on the Fort Apace Indian Reservation T2 - 82nd Annual Conference and Exhibition of the Arizona Water and Pollution Control Association's (AWPCA) AN - 41781865; 5045084 JF - 82nd Annual Conference and Exhibition of the Arizona Water and Pollution Control Association's (AWPCA) AU - Stover, Michael Y1 - 2009/05/06/ PY - 2009 DA - 2009 May 06 KW - Surface water KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41781865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=82nd+Annual+Conference+and+Exhibition+of+the+Arizona+Water+and+Pollution+Control+Association%27s+%28AWPCA%29&rft.atitle=A+Surface+Water+Diversion+and+Treatment+Facility+Project+on+the+Fort+Apace+Indian+Reservation&rft.au=Stover%2C+Michael&rft.aulast=Stover&rft.aufirst=Michael&rft.date=2009-05-06&rft.volume=22&rft.issue=4&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Working+Woman&rft.issn=01455761&rft_id=info:doi/ L2 - http://www.awpca.org/calendar/conference/ConfSessionSummaries.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide. AN - 733098908; 19413904 AB - Nanoparticles are characterized by having a high surface area per mass. Particulate surface area has been reported to play an important role in determining the biological activity of nanoparticles. However, recent reports have questioned this relationship. This study was conducted to determine whether mass of particles or surface area of particles is the more appropriate dose metric for pulmonary toxicity studies. In this study, rats were exposed by intratracheal instillation to various doses of ultrafine and fine carbon black. At 1, 7, or 42 days post-exposure, inflammatory and cytotoxic potential of each particle type was compared on both a mass dosage (mg/rat) as well as an equal surface area dosage (cm2 of particles per cm2 of alveolar epithelium). In an additional study, the pulmonary responses to instillation of ultrafine carbon black were compared to equivalent particle surface area doses of ultrafine titanium dioxide. Ultrafine carbon black particles caused a dose dependent but transient inflammatory and cytotoxic response. On a mass basis, these responses were significantly (65 fold) greater than those for fine sized carbon black. However, when doses were equalized based on surface area of particles given, the ultrafine carbon black particles were only slightly (non-significantly) more inflammogenic and cytotoxic compared to the fine sized carbon black. At one day post-exposure, inflammatory potencies of the ultrafine carbon black and ultrafine titanium dioxide particles were similar. However, while the pulmonary reaction to ultrafine carbon black resolved with time, the inflammatory effects of ultrafine titanium dioxide were more persistent over a 42 day post-exposure period. These results indicate that for low toxicity low solubility materials, surface area of particles administered rather than mass burden of particles may be a more appropriate dose metric for pulmonary toxicity studies. In addition, ultrafine titanium dioxide appears to be more bioactive than ultrafine carbon black on an equivalent surface area of particles delivered basis. JF - Particle and fibre toxicology AU - Sager, Tina M AU - Castranova, Vincent AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. vic1@cdc.gov. Y1 - 2009/05/04/ PY - 2009 DA - 2009 May 04 SP - 15 VL - 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733098908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Surface+area+of+particle+administered+versus+mass+in+determining+the+pulmonary+toxicity+of+ultrafine+and+fine+carbon+black%3A+comparison+to+ultrafine+titanium+dioxide.&rft.au=Sager%2C+Tina+M%3BCastranova%2C+Vincent&rft.aulast=Sager&rft.aufirst=Tina&rft.date=2009-05-04&rft.volume=6&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-6-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-05-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ind Health. 1999 Oct;37(4):353-63 [10547950] Inhal Toxicol. 1996;8 Suppl:73-89 [11542496] Inhal Toxicol. 2002 Mar;14(3):311-24 [12028820] Environ Health Perspect. 2007 Feb;115(2):187-94 [17384763] Am J Respir Cell Mol Biol. 1992 Feb;6(2):235-43 [1540387] J Toxicol Environ Health A. 2002 Aug 23;65(16):1121-40 [12167212] Inhal Toxicol. 2007 Aug;19(10):849-56 [17687716] Occup Environ Med. 2007 Sep;64(9):609-15 [17409182] Occup Environ Med. 2001 Mar;58(3):211-6, 199 [11171936] Environ Health Perspect. 2003 Jun;111(8):1074-92 [12826479] J Occup Environ Hyg. 2007 Dec;4(12):D125-30 [17943583] Environ Health Perspect. 1994 Oct;102 Suppl 5:173-9 [7882925] Inhal Toxicol. 2009 Feb;21(3):234-43 [19016061] Methods Enzymol. 1986;132:498-507 [3821523] Environ Health Perspect. 2006 Mar;114(3):328-33 [16507453] J Occup Environ Med. 2006 Dec;48(12):1314-20 [17159647] Toxicology. 2007 Jan 25;230(1):90-104 [17196727] Toxicol Sci. 2006 May;91(1):227-36 [16495353] J Aerosol Med. 2002 Summer;15(2):213-20 [12184871] Part Fibre Toxicol. 2008;5:17 [19046442] Inhal Toxicol. 2009 Oct;21(12):1053-61 [19555230] Inhal Toxicol. 2008 Jun;20(8):741-9 [18569096] Part Fibre Toxicol. 2008;5:1 [18269765] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1743-8977-6-15 ER - TY - JOUR T1 - Characterization of exposures among cemented tungsten carbide workers. Part II: Assessment of surface contamination and skin exposures to cobalt, chromium and nickel AN - 754885501; 13443701 AB - Cobalt, chromium and nickel are among the most commonly encountered contact allergens in the workplace, all used in the production of cemented tungsten carbides (CTC). Exposures to these metal-containing dusts are frequently associated with skin sensitization and/or development of occupational asthma. The objectives of this study were to assess the levels of cobalt, chromium and nickel on work surfaces and on workers' skin in three CTC production facilities. At least one worker in each of 26 work areas (among all facilities) provided hand and neck wipe samples. Wipe samples were also collected from work surfaces frequently contacted by the 41 participating workers. Results indicated that all surfaces in all work areas were contaminated with cobalt and nickel, with geometric means (GMs) ranging from 4.1 to 3057kg/100cm super(2) and 1.1-185kg/100cm super(2), respectively; most surfaces were contaminated with chromium (GM=0.36-67kg/100cm super(2)). The highest GM levels of all metals were found on control panels, containers and hand tools, whereas lowest levels were on office and telecommunication equipment. The highest GM levels of cobalt and nickel on skin were observed among workers in the powder-handling facility (hands: 388 and 24kg; necks: 55 and 6kg, respectively). Levels of chromium on workers' skin were generally low among all facilities. Geometric standard deviations associated with surface and skin wipe measurements among work areas were highly variable. Exposure assessment indicated widespread contamination of multiple sensitizing metals in these three facilities, suggesting potential transfer of contaminants from surfaces to skin. Specific action, including improved housekeeping and training workers on appropriate use and care of personal protective equipment, should be implemented to reduce pathways of skin exposure. Epidemiologic studies of associated adverse health effects will likely require more biologically relevant exposure metrics to improve the ability to detect exposure-response relationships.Journal of Exposure Science and Environmental Epidemiology (2009) 19, 423-434; doi:10.1038/jes.2008.33; published online 4 June 2008 JF - Journal of Exposure Science and Environmental Epidemiology AU - Day, Gregory A AU - Virji, M Abbas AU - Stefaniak, Aleksandr B AD - aDivision of Respiratory Disease Studies, Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, USA Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 423 EP - 434 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 19 IS - 4 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Pollution Abstracts KW - Contamination KW - Heavy metals KW - Nickel KW - tungsten carbide KW - Dust KW - Tungsten KW - Workers KW - Allergens KW - Cobalt KW - Dose-response effects KW - hand tools KW - Occupational exposure KW - Metals KW - Skin KW - Chromium KW - Asthma KW - Hand KW - Neck KW - Standard deviation KW - Epidemiology KW - Contaminants KW - Internet KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754885501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Characterization+of+exposures+among+cemented+tungsten+carbide+workers.+Part+II%3A+Assessment+of+surface+contamination+and+skin+exposures+to+cobalt%2C+chromium+and+nickel&rft.au=Day%2C+Gregory+A%3BVirji%2C+M+Abbas%3BStefaniak%2C+Aleksandr+B&rft.aulast=Day&rft.aufirst=Gregory&rft.date=2009-05-01&rft.volume=19&rft.issue=4&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2008.33 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Skin; Chromium; Contamination; Heavy metals; Nickel; Hand; Asthma; tungsten carbide; Neck; Dust; Workers; Standard deviation; Epidemiology; Dose-response effects; Cobalt; Allergens; Contaminants; Internet; Occupational exposure; Metals; hand tools; Tungsten DO - http://dx.doi.org/10.1038/jes.2008.33 ER - TY - JOUR T1 - Miniaturized 96-well ELISA chips for staphylococcal enterotoxin B detection using portable colorimetric detector AN - 753651166; 13323805 AB - A previously developed fluorescence sensing platform, combining spatial illumination using electroluminescence (EL) semiconductor strips with charge coupled device (CCD)-based detection (EL-CCD), was adapted to a new 96-well chip for colorimetric immunological assays, enhancing the capabilities of the EL-CCD platform. The modified system was demonstrated using a colorimetric-based enzyme linked immunosorbent assay (ELISA) for detection of staphylococcal enterotoxin B (SEB). Limits of detection (LODs) of 3.9 ng/mL (c2.4 ng/mL) SEB were determined with the ELISA chip measured using the EL-CCD platform, following a standard 4-h ELISA protocol. The LODs were comparable to those obtained using standard 96-well ELISA plates measured using a standard laboratory 96-well plate reader. The miniature 96-well ELISA chip however required as little as 5-kL samples, representing a tenfold reduction in sample volume compared to a standard 96-well ELISA plates. The ELISA chip also demonstrated detection of SEB spiked into various food matrices (milk, mushrooms, and mayonnaise) using limited-to-no sample preparation, with LODs ranging from 3.9 to 18.5 ng/mL depending on the matrix. The EL-CCD platform is versatile, capable of multi-mode detection (e.g., fluorescent and colorimetric along with solution and solid phase assays), and could readily be applied to other field portable or point-of-care applications. JF - Analytical and Bioanalytical Chemistry AU - Sapsford, Kim E AU - Francis, Jesse AU - Sun, Steven AU - Kostov, Yordan AU - Rasooly, Avraham AD - Division of Biology, Office of Science and Engineering Laboratories, CDRH, FDA, Silver Spring, MD 20993, USA, rasoolya@mail.nih.gov PY - 2009 SP - 499 EP - 505 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 394 IS - 2 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts; Microbiology Abstracts B: Bacteriology KW - Food KW - Colorimetry KW - Sample Preparation KW - Assay KW - Enzyme-linked immunosorbent assay KW - Fluorescence KW - Milk KW - Laboratories KW - Enzymes KW - Solids KW - Staphylococcal enterotoxin B KW - Basidiocarps KW - Foods KW - Illumination KW - Standards KW - Mayonnaise KW - Solid phase methods KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - J 02420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753651166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Miniaturized+96-well+ELISA+chips+for+staphylococcal+enterotoxin+B+detection+using+portable+colorimetric+detector&rft.au=Sapsford%2C+Kim+E%3BFrancis%2C+Jesse%3BSun%2C+Steven%3BKostov%2C+Yordan%3BRasooly%2C+Avraham&rft.aulast=Sapsford&rft.aufirst=Kim&rft.date=2009-05-01&rft.volume=394&rft.issue=2&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-009-2730-z L2 - http://www.springerlink.com/content/x73q4g7256171713/?p=54e9bda5905b4bd3b31a2367b35d6921&pi=12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Milk; Fluorescence; Illumination; Food; Colorimetry; Mayonnaise; Solid phase methods; Staphylococcal enterotoxin B; Basidiocarps; Sample Preparation; Foods; Laboratories; Assay; Enzymes; Solids; Standards DO - http://dx.doi.org/10.1007/s00216-009-2730-z ER - TY - JOUR T1 - Interlaboratory Validation of a Real-Time PCR 24-Hour Rapid Method for Detection of Salmonella in Foods AN - 744708795; 12685629 AB - The efficacy of a 24-h Salmonella real-time, or quantitative, PCR (qPCR) detection method was assessed through a collaborative effort involving eight Federal and state laboratories. Eleven foods including mashed potatoes, soft cheese, chili powder, chocolate, eggs, sprouts, apple juice, fish, shrimp, ground beef, and ground chicken were tested. For each food, seven blind samples were distributed to each participant for testing. These included six samples equivalently inoculated with 1 to 5 CFU/25 g of various serotypes of Salmonella (Gaminara, Weltevreden, Heidelberg, Senftenberg, Enteritidis, Newport, Typhimurium, and Kentucky for each food) and 10 to 50 CFU/25 g of the competitor Enterobacter cloacae. The seventh sample was inoculated with 10 to 50 CFU/25 g of the competitor, E. cloacae, only. These samples were tested for Salmonella by using four methods in parallel: (i) 24-h qPCR method detecting Salmonella from modified buffered peptone water enrichment medium; (ii) 48-h qPCR method detecting Salmonella from a secondary selective enrichment broth; (iii) modified Bacteriological Analytical Manual method; and (iv) VIDAS, an immunoassay system. The results of the statistical analysis showed there was no significant (P . 0.05) difference between either of the qPCR methods and the modified Bacteriological Analytical Manual method for 10 of 11 foods. For the one exception, sprouts, detection by qPCR required 48 h. Both qPCR methods showed a detection limit of 0.08 to 0.2 CFU/g. These results provide a solid basis for using this 24-h qPCR rapid screening method to detect Salmonella in foods. JF - Journal of Food Protection AU - Cheng, Chorng-Ming AU - Van, Khanh T AU - Lin, Wen AU - Ruby, Richard M AD - U.S. Food and Drug Administration, Office of Regulatory Affairs, Pacific Regional Laboratory Southwest, 19701 Fairchild, Irvine, California 92612; and 2 U.S. Food and Drug Administration, Office of Regulatory Affairs, Division of Field Science, 5600 Fishers Lane,Room 12-41, Rockville, Maryland 20857, USAMS 08-508: Received 6 October 2008/Accepted 11 January 2009* Author for correspondence. Tel: 949-608-3502; Fax: 949-608-3567; chorng-ming.cheng[AT]fda.hhs.gov. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 945 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 72 IS - 5 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Powder KW - Serotypes KW - Food KW - Statistical analysis KW - Chocolate KW - Cheese KW - Eggs KW - Fruit juices KW - Enterobacter cloacae KW - Beef KW - Solanum tuberosum KW - peptone KW - Colony-forming cells KW - Malus KW - Polymerase chain reaction KW - Salmonella KW - Immunoassays KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744708795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Interlaboratory+Validation+of+a+Real-Time+PCR+24-Hour+Rapid+Method+for+Detection+of+Salmonella+in+Foods&rft.au=Cheng%2C+Chorng-Ming%3BVan%2C+Khanh+T%3BLin%2C+Wen%3BRuby%2C+Richard+M&rft.aulast=Cheng&rft.aufirst=Chorng-Ming&rft.date=2009-05-01&rft.volume=72&rft.issue=5&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 13 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Powder; Serotypes; Food; Statistical analysis; Chocolate; Cheese; Eggs; Fruit juices; Beef; Colony-forming cells; peptone; Polymerase chain reaction; Immunoassays; Enterobacter cloacae; Solanum tuberosum; Malus; Salmonella ER - TY - JOUR T1 - Specificity Analysis of a Novel Phage-Derived Ligand in an Enzyme-Linked Fluorescent Assay for the Detection of Escherichia coli O157:H7 AN - 744701801; 12685647 AB - An assay using a phage-derived ligand to capture Escherichia coli O157:H7 prior to antibody detection was evaluated for assay specificity. Analysis of 200 strains showed that the assay was highly specific for the O157 serogroup. It detected all the O157:H7 strains including Shiga toxin-producing O157 nonmotile strains as well as O157 non-H7 strains. In addition, the assay detected various O157:H7 phenotypic variants that are not easily detected by routine analytical methods, as well as a rough strain that did not express O157 antigen and therefore is undetectable serologically. The phage ligand assay showed no cross-reactivity to the other E. coli serotypes. Isolates of Salmonella group N and a few Citrobacter freundii strains that cross-reacted with anti-O157 sera also showed cross-reactivity with the phage ligand. However, other strains that cross-reacted serologically with anti-O157 sera were correctly identified as negative with the phage ligand assay, including several strains of E. coli that nonspecifically autoagglutinate latex reagents. JF - Journal of Food Protection AU - Rozand, Christine AU - Feng, Peter C H AD - Unite de Microbiologie Alimentaire et Previsionnelle, Ecole Veterinaire de Lyon, Lyon, France; and 2Division of Microbiology, U.S. Food and Drug Administration, College Park, Maryland 20740, USAMS 08-591: Received 1 December 2008/Accepted 14 January 2009* Author for correspondence. Tel: 301-436-1650; peter.feng[AT]fda.hhs.gov. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1078 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 72 IS - 5 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology KW - Phages KW - Antibodies KW - Cross-reactivity KW - Serotypes KW - Citrobacter freundii KW - Escherichia coli KW - Latex KW - Salmonella KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744701801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Specificity+Analysis+of+a+Novel+Phage-Derived+Ligand+in+an+Enzyme-Linked+Fluorescent+Assay+for+the+Detection+of+Escherichia+coli+O157%3AH7&rft.au=Rozand%2C+Christine%3BFeng%2C+Peter+C+H&rft.aulast=Rozand&rft.aufirst=Christine&rft.date=2009-05-01&rft.volume=72&rft.issue=5&rft.spage=1078&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 21 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Phages; Antibodies; Serotypes; Cross-reactivity; Latex; Citrobacter freundii; Escherichia coli; Salmonella ER - TY - JOUR T1 - Evidence of Autoimmune-Related Effects of Trichloroethylene Exposure from Studies in Mice and Humans AN - 743551986; 201004-31-0310516 (CE); 12115942 (EN) AB - OBJECTIVE: Our objective was to examine experimental and epidemiologic studies pertaining to immune-related, and specifically autoimmune-related, effects of trichloroethylene (TCE). DATA SOURCES AND EXTRACTION: We performed a literature search of PubMed and reviewed bibliographies in identified articles. We then systematically reviewed immune-related data, focusing on clinical and immunologic features and mechanistic studies. DATA SYNTHESIS: Studies conducted in MRL+/+ lupus mice report an accelerated autoimmune response in relation to exposure to TCE or some metabolites. Effects have been reported after 4 weeks of exposure to TCE at doses as low as 0.1 mg/kg/day in drinking water and have included increased antinuclear antibodies and interferon-gamma (IFN-gamma) and decreased secretion of interleukin-4 (IL-4), consistent with an inflammatory response. Autoimmune hepatitis, inflammatory skin lesions, and alopecia have been found after exposures of 32-48 weeks. Recent mechanistic experiments in mice examined oxidative stress and, specifically, effects on lipid-peroxidation-derived aldehydes in TCE-induced autoimmune disease. Two studies in humans reported an increase in IL-2 or IFN-gamma and a decrease in IL-4 in relation to occupational or environmental TCE exposure. Occupational exposure to TCE has also been associated with a severe, generalized hypersensitivity skin disorder accompanied by systemic effects, including hepatitis. In three case-control studies of scleroderma with a measure of occupational TCE exposure, the combined odds ratio was 2.5 [95% confidence interval (CI), 1.1-5.4] in men and 1.2 (95% CI, 0.58-2.6) in women. CONCLUSION: The consistency among the studies and the concordance between the studies in mice and humans support an etiologic role of TCE in autoimmune disease. Multisite collaborations and studies of preclinical immune markers are needed to further develop this field of research. JF - Environmental Health Perspectives AU - Cooper, Glinda S AU - Makris, Susan L AU - Nietert, Paul J AU - Jinot, Jennifer PY - 2009 SP - 696 EP - 702 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mice KW - Occupational KW - Human KW - Trichloroethylene KW - Hepatitis KW - Autoimmune diseases KW - Health KW - Focusing KW - Aldehydes KW - Secretions KW - Literature searches KW - Drinking water KW - Inflammatory response KW - Extraction KW - Epidemiology KW - Bibliographies KW - Data sources KW - Disorders KW - Metabolites KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743551986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Evidence+of+Autoimmune-Related+Effects+of+Trichloroethylene+Exposure+from+Studies+in+Mice+and+Humans&rft.au=Cooper%2C+Glinda+S%3BMakris%2C+Susan+L%3BNietert%2C+Paul+J%3BJinot%2C+Jennifer&rft.aulast=Cooper&rft.aufirst=Glinda&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=696&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The University of Michigan Dioxin Exposure Study: Population Survey Results and Serum Concentrations for Polychlorinated Dioxins, Furans, and Biphenyls AN - 743526382; 201004-31-0310500 (CE); 12115926 (EN) AB - BACKGROUND: The University of Michigan Dioxin Exposure Study was undertaken to address concerns that the discharge of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzo furans (PCDFs) from the Dow Chemical Company in the Midland, Michigan, area had resulted in contamination of soils in the Tittabawassee River floodplain and the city of Midland, leading to an increase in residents' body burdens of these compounds. OBJECTIVE: In this article we present descriptive statistics from the resident survey and sampling of human serum, household dust, and soil and compare them with other published values. METHODS: From a multistage random sample of populations in four areas of Midland and Saginaw counties and from a distant referent population, we interviewed 946 adults, who also donated blood for analysis of PCDDs, PCDFs, and polychlorinated biphenyls (PCBs). Samples of household dust and house perimeter soil were collected from consenting subjects who owned their property. RESULTS: All five study populations were comparable in age, race, sex, and length of residence in their current home. Regional differences existed in employment history, personal contact with contaminated soils, and consumption of fish and game from contaminated areas. Median soil concentrations were significantly increased around homes in the Tittabawassee River floodplain (11.4 ppt) and within the city of Midland (58.2 ppt) compared with the referent population (3.6 ppt). Median serum toxic equivalencies were significantly increased in people who lived in the floodplain (23.2 ppt) compared with the referent population (18.5 ppt). CONCLUSIONS: Differences in serum dioxin concentrations among the populations were small but statistically significant. Regression modeling is needed to identify whether the serum concentrations of PCDDs, PCDFs, and PCBs are associated with contaminated soils, household dust, and other factors. JF - Environmental Health Perspectives AU - Hedgeman, Elizabeth AU - Chen, Qixuan AU - Hong, Biling AU - Chang, Chiung-Wen AU - Olson, Kristen AU - LaDronka, Kathleen AU - Ward, Barbara AU - Adriaens, Peter AU - Demond, Avery AU - Gillespie, Brenda W AU - Lepkowski, James AU - Franzblau, Alfred AU - Garabrant, David H PY - 2009 SP - 811 EP - 817 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Soils KW - Serums KW - Contamination KW - Dioxins KW - Mathematical models KW - Households KW - Statistical analysis KW - Statistical methods KW - Furans KW - Dust KW - Samples KW - Health KW - Rivers KW - Multistage KW - Dust control KW - Discharge KW - Race KW - Polychlorinated biphenyls KW - Regional KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743526382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+University+of+Michigan+Dioxin+Exposure+Study%3A+Population+Survey+Results+and+Serum+Concentrations+for+Polychlorinated+Dioxins%2C+Furans%2C+and+Biphenyls&rft.au=Hedgeman%2C+Elizabeth%3BChen%2C+Qixuan%3BHong%2C+Biling%3BChang%2C+Chiung-Wen%3BOlson%2C+Kristen%3BLaDronka%2C+Kathleen%3BWard%2C+Barbara%3BAdriaens%2C+Peter%3BDemond%2C+Avery%3BGillespie%2C+Brenda+W%3BLepkowski%2C+James%3BFranzblau%2C+Alfred%3BGarabrant%2C+David+H&rft.aulast=Hedgeman&rft.aufirst=Elizabeth&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The University of Michigan Dioxin Exposure Study: Predictors of Human Serum Dioxin Concentrations in Midland and Saginaw, Michigan AN - 743525926; 201004-31-0310499 (CE); 12115925 (EN) AB - BACKGROUND: We conducted a population-based human exposure study in response to concerns among the population of Midland and Saginaw counties, Michigan, that discharges by the Dow Chemical Company of dioxin-like compounds into the nearby river and air had led to an increase in residents' body burdens of polychlorinated dibenzofurans (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs), here collectively referred to as "dioxins." OBJECTIVES: We sought to identify factors that explained variation in serum dioxin concentrations among the residents of Midland and Saginaw counties. Exposures to dioxins in soil, river sediments, household dust, historic emissions, and contaminated fish and game were of primary interest. METHODS: We studied 946 people in four populations in the contaminated area and in a referent population, by interview and by collection of serum, household dust, and residential soil. Linear regression was used to identify factors associated with serum dioxins. RESULTS: Demographic factors explained a large proportion of variation in serum dioxin concentrations. Historic exposures before 1980, including living in the Midland/Saginaw area, hunting and fishing in the contaminated areas, and working at Dow, contributed to serum dioxin levels. Exposures since 1980 in Midland and Saginaw counties contributed little to serum dioxins. CONCLUSIONS: This study provides valuable insights into the relationships between serum dioxins and environmental factors, age, sex, body mass index, smoking, and breast-feeding. These factors together explain a substantial proportion of the variation in serum dioxin concentrations in the general population. Historic exposures to environmental contamination appeared to be of greater importance than recent exposures for dioxins. JF - Environmental Health Perspectives AU - Garabrant, David H AU - Franzblau, Alfred AU - Lepkowski, James AU - Gillespie, Brenda W AU - Adriaens, Peter AU - Demond, Avery AU - Hedgeman, Elizabeth AU - Knutson, Kristine AU - Zwica, Lynn AU - Olson, Kristen AU - Towey, Timothy AU - Chen, Qixuan AU - Hong, Biling AU - Chang, Chiung-Wen AU - Lee, Shih-Yuan AU - Ward, Barbara AU - LaDronka, Kathy AU - Luksemburg, William AU - Maier, Martha PY - 2009 SP - 818 EP - 824 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Dioxins KW - Serums KW - Contamination KW - Historic KW - Households KW - Health KW - Rivers KW - Soil (material) KW - Human KW - Regression KW - Hunting KW - Fish KW - Sediments KW - Dust control KW - Games KW - Dust KW - Fishing KW - Demographics KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743525926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+University+of+Michigan+Dioxin+Exposure+Study%3A+Predictors+of+Human+Serum+Dioxin+Concentrations+in+Midland+and+Saginaw%2C+Michigan&rft.au=Garabrant%2C+David+H%3BFranzblau%2C+Alfred%3BLepkowski%2C+James%3BGillespie%2C+Brenda+W%3BAdriaens%2C+Peter%3BDemond%2C+Avery%3BHedgeman%2C+Elizabeth%3BKnutson%2C+Kristine%3BZwica%2C+Lynn%3BOlson%2C+Kristen%3BTowey%2C+Timothy%3BChen%2C+Qixuan%3BHong%2C+Biling%3BChang%2C+Chiung-Wen%3BLee%2C+Shih-Yuan%3BWard%2C+Barbara%3BLaDronka%2C+Kathy%3BLuksemburg%2C+William%3BMaier%2C+Martha&rft.aulast=Garabrant&rft.aufirst=David&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=818&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Toxicity Data Landscape for Environmental Chemicals AN - 743523669; 201004-31-0310517 (CE); 12115943 (EN) AB - OBJECTIVE: Thousands of chemicals are in common use, but only a portion of them have undergone significant toxicologic evaluation, leading to the need to prioritize the remainder for targeted testing. To address this issue, the U.S. Environmental Protection Agency (EPA) and other organizations are developing chemical screening and prioritization programs. As part of these efforts, it is important to catalog, from widely dispersed sources, the toxicology information that is available. The main objective of this analysis is to define a list of environmental chemicals that are candidates for the U.S. EPA screening and prioritization process, and to catalog the available toxicology information. DATA SOURCES: We are developing ACToR (Aggregated Computational Toxicology Resource), which combines information for hundreds of thousands of chemicals from 200 public sources, including the U.S. EPA, National Institutes of Health, Food and Drug Administration, corresponding agencies in Canada, Europe, and Japan, and academic sources. DATA EXTRACTION: ACToR contains chemical structure information; physical-chemical properties; in vitro assay data; tabular in vivo data; summary toxicology calls (e.g., a statement that a chemical is considered to be a human carcinogen); and links to online toxicology summaries. Here, we use data from ACToR to assess the toxicity data landscape for environmental chemicals. DATA SYNTHESIS: We show results for a set of 9,912 environmental chemicals being considered for analysis as part of the U.S. EPA ToxCast screening and prioritization program. These include high-and medium-production-volume chemicals, pesticide active and inert ingredients, and drinking water contaminants. CONCLUSIONS: Approximately two-thirds of these chemicals have at least limited toxicity summaries available. About one-quarter have been assessed in at least one highly curated toxicology evaluation database such as the U.S. EPA Toxicology Reference Database, U.S. EPA Integrated Risk Information System, and the National Toxicology Program. JF - Environmental Health Perspectives AU - Judson, Richard AU - Richard, Ann AU - Dix, David J AU - Houck, Keith AU - Martin, Matthew AU - Kavlock, Robert AU - Dellarco, Vicki AU - Henry, Tala AU - Holderman, Todd AU - Sayre, Philip AU - Tan, Shirlee AU - Carpenter, Thomas AU - Smith, Edwin PY - 2009 SP - 685 EP - 695 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Biocompatibility KW - Toxicology KW - Databases KW - Toxicity KW - Screening KW - Health KW - Summaries KW - Catalogs KW - Landscapes KW - Inert KW - Drinking water KW - Synthesis KW - Computation KW - Ingredients KW - Pesticides KW - Links KW - In vivo testing KW - Copyrights KW - In vitro testing KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743523669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Toxicity+Data+Landscape+for+Environmental+Chemicals&rft.au=Judson%2C+Richard%3BRichard%2C+Ann%3BDix%2C+David+J%3BHouck%2C+Keith%3BMartin%2C+Matthew%3BKavlock%2C+Robert%3BDellarco%2C+Vicki%3BHenry%2C+Tala%3BHolderman%2C+Todd%3BSayre%2C+Philip%3BTan%2C+Shirlee%3BCarpenter%2C+Thomas%3BSmith%2C+Edwin&rft.aulast=Judson&rft.aufirst=Richard&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Statistical Modeling Suggests that Antiandrogens in Effluents from Wastewater Treatment Works Contribute to Widespread Sexual Disruption in Fish Living in English Rivers AN - 743494439; 201004-31-0310502 (CE); 12115928 (EN) AB - BACKGROUND: The widespread occurrence of feminized male fish downstream of some wastewater treatment works has led to substantial interest from ecologists and public health professionals. This concern stems from the view that the effects observed have a parallel in humans, and that both phenomena are caused by exposure to mixtures of contaminants that interfere with reproductive development. The evidence for a "wildlife-human connection" is, however, weak: Testicular dysgenesis syndrome, seen in human males, is most easily reproduced in rodent models by exposure to mixtures of antiandrogenic chemicals. In contrast, the accepted explanation for feminization of wild male fish is that it results mainly from exposure to steroidal estrogens originating primarily from human excretion. OBJECTIVES: We sought to further explore the hypothesis that endocrine disruption in fish is multicausal, resulting from exposure to mixtures of chemicals with both estrogenic and antiandrogenic properties. METHODS: We used hierarchical generalized linear and generalized additive statistical modeling to explore the associations between modeled concentrations and activities of estrogenic and antiandrogenic chemicals in 30 U.K. rivers and feminized responses seen in wild fish living in these rivers. RESULTS: In addition to the estrogenic substances, antiandrogenic activity was prevalent in almost all treated sewage effluents tested. Further, the results of the modeling demonstrated that feminizing effects in wild fish could be best modeled as a function of their predicted exposure to both antiandrogens and estrogens or to antiandrogens alone. CONCLUSION: The results provide a strong argument for a multicausal etiology of widespread feminization of wild fish in U.K. rivers involving contributions from both steroidal estrogens and xenoestrogens and from other (as yet unknown) contaminants with antiandrogenic properties. These results may add further credence to the hypothesis that endocrine-disrupting effects seen in wild fish and in humans are caused by similar combinations of endocrine-disrupting chemical cocktails. JF - Environmental Health Perspectives AU - Jobling, Susan AU - Burn, Robert W AU - Thorpe, Karen AU - Williams, Richard AU - Tyler, Charles PY - 2009 SP - 797 EP - 802 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Fish KW - Rivers KW - Human KW - Estrogens KW - Males KW - Contaminants KW - Health KW - Wastewater treatment KW - Disruption KW - Effluents KW - Stems KW - Ecology KW - Burns KW - Excretion KW - Connecting rods KW - Additives KW - Copyrights KW - Treated sewage KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743494439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Statistical+Modeling+Suggests+that+Antiandrogens+in+Effluents+from+Wastewater+Treatment+Works+Contribute+to+Widespread+Sexual+Disruption+in+Fish+Living+in+English+Rivers&rft.au=Jobling%2C+Susan%3BBurn%2C+Robert+W%3BThorpe%2C+Karen%3BWilliams%2C+Richard%3BTyler%2C+Charles&rft.aulast=Jobling&rft.aufirst=Susan&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=797&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Association of Environmental Cadmium Exposure with Periodontal Disease in U.S. Adults AN - 743473029; 201004-31-0310510 (CE); 12115936 (EN) AB - BACKGROUND: Periodontal disease is a complex, multifactorial, chronic inflammatory disease that involves degradation of periodontal structures, including alveolar bone. Cadmium adversely affects bone remodeling, and it is therefore possible that environmental Cd exposure may be a risk factor for periodontal-disease-related bone loss. OBJECTIVE: We examined the relationship between environmental Cd exposure and periodontal disease in U.S. adults. METHODS: We analyzed cross-sectional data from the third National Health and Nutrition Examination Survey (NHANES III). We defined periodontal disease as clinical attachment loss of at least 4 mm in 10% of sites examined. We used multivariable-adjusted logistic regression analyses to estimate the association between creatinine-corrected urinary Cd levels and periodontal disease. RESULTS: Of the 11,412 participants included in this study, 15.4% had periodontal disease. The age-adjusted geometric mean urine Cd concentration (micrograms per gram creatinine) was significantly higher among participants with periodontal disease [0.50; 95% confidence interval (CI), 0.45-0.56] than among those without periodontal disease (0.30; 95% CI, 0.28-0.31). Multivariable-adjusted analyses, which included extensive adjustments for tobacco exposure, showed that a 3-fold increase in creatinine-corrected urinary Cd concentrations [corresponding to an increment from the 25th (0.18 microg/g) to the 75th (0.63 microg/g) percentile] was associated with 54% greater odds of prevalent periodontal disease (odds ratio = 1.54; 95% CI, 1.26-1.87). We observed similar results among the subset of participants who had limited exposure to tobacco, but only after removing six influential observations. CONCLUSION: Environmental Cd exposure was associated with higher odds of periodontal disease. JF - Environmental Health Perspectives AU - Arora, Manish AU - Weuve, Jennifer AU - Schwartz, Joel AU - Wright, Robert O PY - 2009 SP - 739 EP - 744 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Periodontal disease KW - Cadmium KW - Bones KW - Health KW - Adults KW - Tobacco KW - Nutrition KW - Risk KW - Estimates KW - Degradation KW - Remodeling KW - Regression analysis KW - Confidence intervals KW - Copyrights KW - Creatinine KW - Logistics KW - Urine KW - Adjustment KW - Attachment KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743473029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Association+of+Environmental+Cadmium+Exposure+with+Periodontal+Disease+in+U.S.+Adults&rft.au=Arora%2C+Manish%3BWeuve%2C+Jennifer%3BSchwartz%2C+Joel%3BWright%2C+Robert+O&rft.aulast=Arora&rft.aufirst=Manish&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Spontaneous Cytokine Production in Children According to Biological Characteristics and Environmental Exposures AN - 743465498; 201004-31-0310495 (CE); 12115921 (EN) AB - BACKGROUND: Environmental factors are likely to have profound effects on the development of host immune responses, with serious implications for infectious diseases and inflammatory disorders such as asthma. OBJECTIVE: This study was designed to investigate the effects of environmental exposures on the cytokine profile of children. METHODS: The study involved measurement of T helper (Th) 1 (interferon-gamma), 2 [interleukin (IL)-5 and IL-13], and the regulatory cytokine IL-10 in unstimulated peripheral blood leukocytes from 1,376 children 4-11 years of age living in a poor urban area of the tropics. We also assessed the impact of environmental exposures in addition to biological characteristics recorded at the time of blood collection and earlier in childhood (0-3 years before blood collection). RESULTS: The proportion of children producing IL-10 was greater among those without access to drinking water [p 0.05, chi-square test, odds ratio (OR) = 1.67]. The proportion of children producing IL-5 and IL-10 (OR = 10.76) was significantly greater in households that had never had a sewage system (p 0.05, trend test). CONCLUSIONS: These data provide evidence for the profound effects of environmental exposures in early life as well as immune homeostasis in later childhood. Decreased hygiene (lack of access to clean drinking water and sanitation) in the first 3 years of life is associated with higher spontaneous IL-10 production up to 8 years later in life. JF - Environmental Health Perspectives AU - Fiqueiredo, Camila Alexandrina AU - Alcantara-Neves, Neuza Maria AU - Veiga, Rafael AU - Amorim, Leila D AU - Dattoli, Vitor AU - Mendonca, Livia Ribeiro AU - Junqueira, Samuel AU - Genser, Bernd AU - Santos, Mariese AU - de Carvalho, Lain Carlos Pontes AU - Cooper, Philip J AU - Rodrigues, Laura AU - Barreto, Mauricio L PY - 2009 SP - 845 EP - 849 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Exposure KW - Cytokines KW - Blood KW - Drinking water KW - Biological KW - Spontaneous KW - Health KW - Collection KW - Urban areas KW - Asthma KW - Sanitation KW - Households KW - Infectious diseases KW - Disorders KW - Homeostasis KW - Cleaning KW - Leukocytes KW - Tropics KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743465498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Spontaneous+Cytokine+Production+in+Children+According+to+Biological+Characteristics+and+Environmental+Exposures&rft.au=Fiqueiredo%2C+Camila+Alexandrina%3BAlcantara-Neves%2C+Neuza+Maria%3BVeiga%2C+Rafael%3BAmorim%2C+Leila+D%3BDattoli%2C+Vitor%3BMendonca%2C+Livia+Ribeiro%3BJunqueira%2C+Samuel%3BGenser%2C+Bernd%3BSantos%2C+Mariese%3Bde+Carvalho%2C+Lain+Carlos+Pontes%3BCooper%2C+Philip+J%3BRodrigues%2C+Laura%3BBarreto%2C+Mauricio+L&rft.aulast=Fiqueiredo&rft.aufirst=Camila&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Review of the Occurrence of Anti-infectives in Contaminated Wastewaters and Natural and Drinking Waters AN - 743440180; 201004-31-0310518 (CE); 12115944 (EN) AB - OBJECTIVE: Anti-infectives are constantly discharged at trace levels in natural waters near urban centers and agricultural areas. They represent a cause for concern because of their potential contribution to the spread of anti-infective resistance in bacteria and other effects on aquatic biota. We compiled data on the occurrence of anti-infectives published in the last 24 years in environmental water matrices. The collected information was then compared with the available ecotoxicologic values to evaluate potential environmental concerns. DATA SOURCES: We used Web of Science and Google Scholar to search for articles published in peer-reviewed journals written in the English language since 1984. DATA EXTRACTION: Information on compound concentrations in wastewaters and natural and drinking waters, the source of contamination, country of provenance of the samples, year of publication, limits of quantification, and method of analysis was extracted. DATA SYNTHESIS: From the 126 different substances analyzed in environmental waters, 68 different parent compounds and 10 degradation products or metabolites have been quantified to date. Environmental concentrations vary from about 10(-1) to 10(9) ng/L, depending on the compound, the matrix, and the source of contamination. CONCLUSIONS: Detrimental effects of anti-infectives on aquatic microbiota are possible with the constant exposure of sensitive species. Indirect impact on human health cannot be ruled out when considering the potential contribution of high anti-infective concentrations to the spreading of anti-infective resistance in bacteria. JF - Environmental Health Perspectives AU - Segura, Pedro A AU - Francois, Matthieu AU - Gagnon, Christian AU - Sauve, Sebastien PY - 2009 SP - 675 EP - 684 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Bacteria KW - Drinking water KW - Waste water KW - Microorganisms KW - Health KW - Contamination KW - Searching KW - Spreads KW - Matrices KW - Extraction KW - Data sources KW - Metabolites KW - Degradation KW - Aquatic biota KW - Mathematical analysis KW - Spreading KW - Discharge KW - Parents KW - Matrix methods KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743440180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Review+of+the+Occurrence+of+Anti-infectives+in+Contaminated+Wastewaters+and+Natural+and+Drinking+Waters&rft.au=Segura%2C+Pedro+A%3BFrancois%2C+Matthieu%3BGagnon%2C+Christian%3BSauve%2C+Sebastien&rft.aulast=Segura&rft.aufirst=Pedro&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Subclinical Hypothyroidism after Radioiodine Exposure: Ukrainian-American Cohort Study of Thyroid Cancer and Other Thyroid Diseases after the Chornobyl Accident (1998-2000) AN - 743433433; 201004-31-0310509 (CE); 12115935 (EN) AB - BACKGROUND: Hypothyroidism is the most common thyroid abnormality in patients treated with high doses of iodine-131 (131I). Data on risk of hypothyroidism from low to moderate 131I thyroid doses are limited and inconsistent. OBJECTIVE: This study was conducted to quantify the risk of hypothyroidism prevalence in relation to 131I doses received because of the Chornobyl accident. METHODS: This is a cross-sectional (1998-2000) screening study of thyroid diseases in a cohort of 11,853 individuals 18 years of age at the time of the accident, with individual thyroid radioactivity measurements taken within 2 months of the accident. We measured thyroid-stimulating hormone (TSH), free thyroxine, and antibodies to thyroid peroxidase (ATPO) in serum. RESULTS: Mean age at examination of the analysis cohort was 21.6 years (range, 12.2-32.5 years), with 49% females. Mean 131I thyroid dose was 0.79 Gy (range, 0-40.7 Gy). There were 719 cases with hypothyroidism (TSH 4 mIU/L), including 14 with overt hypothyroidism. We found a significant, small association between (131)I thyroid doses and prevalent hypothyroidism, with the excess odds ratio (EOR) per gray of 0.10 (95% confidence interval, 0.03-0.21). EOR per gray was higher in individuals with ATPO or = 60 U/mL compared with individuals with ATPO 60 U/mL (p 0.001). CONCLUSIONS: This is the first study to find a significant relationship between prevalence of hypothyroidism and individual (131)I thyroid doses due to environmental exposure. The radiation increase in hypothyroidism was small (10% per Gy) and limited largely to subclinical hypothyroidism. Prospective data are needed to evaluate the dynamics of radiation-related hypothyroidism and clarify the role of antithyroid antibodies. JF - Environmental Health Perspectives AU - Ostroumova, Evgenia AU - Brenner, Alina AU - Oliynyk, Valery AU - McConnell, Robert AU - Robbins, Jacob AU - Terekhova, Galina AU - Zablotska, Lydia AU - Likhtarev, Ilya AU - Bouville, Andre AU - Shpak, Viktor AU - Markov, Valentin AU - Masnyk, Ihor AU - Ron, Elaine AU - Tronko, Mykola AU - Hatch, Maureen PY - 2009 SP - 745 EP - 750 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Accident analysis KW - Accidents KW - Diseases KW - Risk KW - Health KW - Antibodies KW - Uranium KW - Age KW - Radioactivity KW - Patients KW - Thyroxine KW - Hormones KW - Dynamic tests KW - Confidence intervals KW - Cancer KW - Dynamics KW - Copyrights KW - Peroxidase KW - Females KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743433433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Subclinical+Hypothyroidism+after+Radioiodine+Exposure%3A+Ukrainian-American+Cohort+Study+of+Thyroid+Cancer+and+Other+Thyroid+Diseases+after+the+Chornobyl+Accident+%281998-2000%29&rft.au=Ostroumova%2C+Evgenia%3BBrenner%2C+Alina%3BOliynyk%2C+Valery%3BMcConnell%2C+Robert%3BRobbins%2C+Jacob%3BTerekhova%2C+Galina%3BZablotska%2C+Lydia%3BLikhtarev%2C+Ilya%3BBouville%2C+Andre%3BShpak%2C+Viktor%3BMarkov%2C+Valentin%3BMasnyk%2C+Ihor%3BRon%2C+Elaine%3BTronko%2C+Mykola%3BHatch%2C+Maureen&rft.aulast=Ostroumova&rft.aufirst=Evgenia&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Predictors of Endotoxin Levels in U.S. Housing AN - 743384966; 201004-31-0310506 (CE); 12115932 (EN) AB - BACKGROUND: The relationship of domestic endotoxin exposure to allergy and asthma has been widely investigated. However, few studies have evaluated predictors of household endotoxin, and none have done so for multiple locations within homes and on a national scale. OBJECTIVES: We assayed 2,552 house dust samples in a nationwide study to understand the predictors of household endotoxin in bedroom floors, family room floors, beds, kitchen floors, and family room sofas. METHODS: Reservoir house dust from five locations within homes was assayed for endotoxin and demographic and housing information was assessed through questionnaire and onsite evaluation of 2,456 residents of 831 homes selected to represent national demographics. We performed repeated-measures analysis of variance (rANOVA) for 37 candidate variables to identify independent predictors of endotoxin. Meteorologic data were obtained for each primary sampling unit and tested as predictors of indoor endotoxin to determine if wetter or warmer microclimates were associated with higher endotoxin levels. RESULTS: Weighted geometric mean endotoxin concentration ranged from 18.7 to 80.5 endotoxin units (EU)/mg for the five sampling locations, and endotoxin load ranged from 4,160 to 19,500 EU/m(2). Bivariate analyses and rANOVA demonstrated that major predictors of endotoxin concentration were sampling location in the home, census division, educational attainment, presence of children, current dog ownership, resident-described problems with cockroaches, food debris, cockroach stains, and evidence of smoking observed by field staff. Low household income entered the model if educational attainment was removed. CONCLUSION: Increased endotoxin in household reservoir dust is principally associated with poverty, people, pets, household cleanliness, and geography. JF - Environmental Health Perspectives AU - Thorne, Peter S AU - Cohn, Richard D AU - Mav, Deepak AU - Arbes, Samuel J AU - Zeldin, Darryl C PY - 2009 SP - 763 EP - 771 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Endotoxins KW - Mathematical models KW - Households KW - Sampling KW - Dust KW - Houses KW - Reservoirs KW - Education KW - Health KW - Cockroaches KW - Housing KW - Demographics KW - Assaying KW - Asthma KW - Bedrooms KW - Bivariate analysis KW - Analysis of variance KW - Children KW - Census KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743384966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Predictors+of+Endotoxin+Levels+in+U.S.+Housing&rft.au=Thorne%2C+Peter+S%3BCohn%2C+Richard+D%3BMav%2C+Deepak%3BArbes%2C+Samuel+J%3BZeldin%2C+Darryl+C&rft.aulast=Thorne&rft.aufirst=Peter&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Neonatal Exposure to Bisphenol A Alters Reproductive Parameters and Gonadotropin Releasing Hormone Signaling in Female Rats AN - 743344522; 201004-31-0310507 (CE); 12115933 (EN) AB - BACKGROUND: Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins, and polystyrene and is found in many products. Several reports have revealed potent in vivo effects, because BPA acts as an estrogen agonist and/or antagonist and as an androgen and thyroid hormone antagonist. OBJECTIVES: We analyzed the effects of neonatal exposure to BPA on the reproductive axis of female Sprague-Dawley rats. METHODS: Female rats were injected subcutaneously, daily, from postnatal day 1 (PND1) to PND10 with BPA [500 microg/50 microL (high) or 50 microg/50 microL (low)] in castor oil or with castor oil vehicle alone. We studied body weight and age at vaginal opening, estrous cycles, and pituitary hormone release in vivo and in vitro, as well as gonadotropin-releasing hormone (GnRH) pulsatility at PND13 and in adults. We also analyzed two GnRH-activated signaling pathways in the adults: inositol-triphosphate (IP(3)), and extracellular signal-regulated kinase(1/2) (ERK(1/2)). RESULTS: Exposure to BPA altered pituitary function in infantile rats, lowering basal and GnRH-induced luteinizing hormone (LH) and increasing GnRH pulsatility. BPA dose-dependently accelerated puberty onset and altered estrous cyclicity, with the high dose causing permanent estrus. In adults treated neonatally with BPA, GnRH-induced LH secretion in vivo was decreased and GnRH pulsatility remained disrupted. In vitro, pituitary cells from animals treated with BPA showed lower basal LH and dose-dependently affected GnRH-induced IP(3) formation; the high dose also impaired GnRH-induced LH secretion. Both doses altered ERK(1/2) activation. CONCLUSIONS: Neonatal exposure to BPA altered reproductive parameters and hypothalamic-pituitary function in female rats. To our knowledge, these results demonstrate for the first time that neonatal in vivo BPA permanently affects GnRH pulsatility and pituitary GnRH signaling. JF - Environmental Health Perspectives AU - Fernandez, Marina AU - Bianchi, Maria AU - Lux-Lantos, Victoria AU - Libertun, Carlos PY - 2009 SP - 757 EP - 762 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Rats KW - Surgical implants KW - Biomedical materials KW - Hormones KW - In vivo tests KW - In vivo testing KW - Females KW - Biocompatibility KW - Adults KW - Secretions KW - Bisphenol A KW - In vitro testing KW - Health KW - Castor oil KW - Activation KW - Polystyrene resins KW - Pituitary hormones KW - Marinas KW - Estrogens KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743344522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Neonatal+Exposure+to+Bisphenol+A+Alters+Reproductive+Parameters+and+Gonadotropin+Releasing+Hormone+Signaling+in+Female+Rats&rft.au=Fernandez%2C+Marina%3BBianchi%2C+Maria%3BLux-Lantos%2C+Victoria%3BLibertun%2C+Carlos&rft.aulast=Fernandez&rft.aufirst=Marina&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats AN - 743317528; 201004-31-0310514 (CE); 12115940 (EN) AB - BACKGROUND: Exposure to combustion-derived fine particulate matter (PM) is associated with increased cardiovascular morbidity and mortality especially in individuals with cardiovascular disease, including hypertension. PM inhalation causes several adverse changes in cardiac function that are reflected in the electrocardiogram (ECG), including altered cardiac rhythm, myocardial ischemia, and reduced heart rate variability (HRV). The sensitivity and reliability of ECG-derived parameters as indicators of the cardiovascular toxicity of PM in rats are unclear. OBJECTIVE: We hypothesized that spontaneously hypertensive (SH) rats are more susceptible to the development of PM-induced arrhythmia, altered ECG morphology, and reduced HRV than are Wistar Kyoto (WKY) rats, a related strain with normal blood pressure. METHODS: We exposed rats once by nose-only inhalation for 4 hr to residual oil fly ash (ROFA), an emission source particle rich in transition metals, or to air and then sacrificed them 1 or 48 hr later. RESULTS: ROFA-exposed SH rats developed non-conducted P-wave arrhythmias but no changes in ECG morphology or HRV. We found no ECG effects in ROFA-exposed WKY rats. ROFA-exposed SH rats also had greater pulmonary injury, neutrophil infiltration, and serum C-reactive protein than did ROFA-exposed WKY rats. CONCLUSIONS: These results suggest that cardiac arrhythmias may be an early sensitive indicator of the propensity for PM inhalation to modify cardiovascular function. JF - Environmental Health Perspectives AU - Farraj, Aimen K AU - Haykal-Coates, Najwa AU - Winsett, Darrell W AU - Hazari, Mehdi S AU - Carll, Alex P AU - Rowan, William H AU - Ledbetter, Allen D AU - Cascio, Wayne E AU - Costa, Daniel L PY - 2009 SP - 709 EP - 715 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Rats KW - Arrhythmia KW - Inhalation KW - Fly ash KW - Morphology KW - Health KW - Indicators KW - Toxicity KW - Heart rate KW - Infiltration KW - Ischemia KW - Mortality KW - Rhythm KW - Injuries KW - Copyrights KW - Transition metals KW - Strain KW - Serums KW - Blood pressure KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743317528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Increased+Nonconducted+P-Wave+Arrhythmias+after+a+Single+Oil+Fly+Ash+Inhalation+Exposure+in+Hypertensive+Rats&rft.au=Farraj%2C+Aimen+K%3BHaykal-Coates%2C+Najwa%3BWinsett%2C+Darrell+W%3BHazari%2C+Mehdi+S%3BCarll%2C+Alex+P%3BRowan%2C+William+H%3BLedbetter%2C+Allen+D%3BCascio%2C+Wayne+E%3BCosta%2C+Daniel+L&rft.aulast=Farraj&rft.aufirst=Aimen&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Ambient Fine Particulate Matter Exposure and Myocardial Ischemia in the Environmental Epidemiology of Arrhythmogenesis in the Women's Health Initiative (EEAWHI) Study AN - 743278324; 201004-31-0310508 (CE); 12115934 (EN) AB - BACKGROUND: Ambient particulate matter (PM) air pollution is associated with coronary heart disease, but the pathways underlying the association remain to be elucidated. METHODS: We studied the association between PM and ischemia among 57,908 Women's Health Initiative clinical trial participants from 1999-2003. We used the Minnesota Code criteria to identify ST-segment and T-wave abnormalities, and estimated T amplitude (microvolt) from resting, standard 12-lead electrocardiogram (ECG). We used U.S. Environmental Protection Agency's monitor data to estimate concentrations of PM 2.5 microm (PM(2.5)) at geocoded participant addresses over 6 days before the ECGs (lag0 through lag5). We excluded 2,379 women with ECG QRS duration or = 120 msec. RESULTS: Overall, 6% of the remaining 55,529 women (52-90 years of age; 83% non-Hispanic white) had ST abnormalities and 16% had T abnormalities. Lead-specific T amplitude was normally distributed (range of means from -14 to 349 microV). PM(2.5) (mean +/- SD) averaged over lag(0-2) was 14 +/- 7 microg/m(3). In logistic and linear regression models adjusted for demographic, clinical, temporal, and climatic factors, a 10-microg/m(3) increase in lag(0-2) PM(2.5) was associated with a 4% [95% confidence interval (CI), -3%, to 10%] increase in the odds of ST abnormality and a 5% (95% CI, 0% to 9%) increase in the odds of T abnormality. We observed corresponding decreases in T amplitude in all exam sites and leads except lead V1, reaching a minimum of -2 microV (95% CI, -5 to 0 microV) in lead V3. CONCLUSIONS: Short-term PM(2.5) exposure is associated with ECG evidence of myocardial ischemia among postmenopausal women. The principal manifestations include subclinical but potentially arrhythmogenic ST-T abnormalities and decreases in T amplitude. JF - Environmental Health Perspectives AU - Zhang, Zhu-ming AU - Whitsel, Eric A AU - Quibrera, P Miguel AU - Smith, Richard L AU - Liao, Duanping AU - Anderson, Garnet L AU - Prineas, Ronald J PY - 2009 SP - 751 EP - 756 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Abnormalities KW - Health KW - Amplitudes KW - Ischemia KW - Mathematical models KW - Air pollution KW - Heart diseases KW - Monitors KW - Regression KW - Epidemiology KW - Estimates KW - Criteria KW - Standards KW - Garnets KW - Confidence intervals KW - Demographics KW - Copyrights KW - Pathways KW - Logistics KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743278324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Ambient+Fine+Particulate+Matter+Exposure+and+Myocardial+Ischemia+in+the+Environmental+Epidemiology+of+Arrhythmogenesis+in+the+Women%27s+Health+Initiative+%28EEAWHI%29+Study&rft.au=Zhang%2C+Zhu-ming%3BWhitsel%2C+Eric+A%3BQuibrera%2C+P+Miguel%3BSmith%2C+Richard+L%3BLiao%2C+Duanping%3BAnderson%2C+Garnet+L%3BPrineas%2C+Ronald+J&rft.aulast=Zhang&rft.aufirst=Zhu-ming&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Long-Term Traffic-Related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway AN - 743263957; 201004-31-0310496 (CE); 12115922 (EN) AB - BACKGROUND: Whether there is a causal relation between long-term exposure to traffic and asthma development is so far not clear. This may be explained by inaccurate exposure assessment. OBJECTIVE: We investigated the associations of long-term traffic-related exposures with asthma onset assessed retrospectively and respiratory symptoms in 9- to 10-year-old children. METHODS: We collected information on respiratory outcomes and potential confounding variables by parental questionnaire in 2,871 children in Oslo. Nitrogen dioxide exposure was assessed by the EPISODE dispersion model and assigned at updated individual addresses during lifetime. Distance to major road was assigned at birth address and address by date of questionnaire. Cox proportional hazard regression and logistic regression were used. RESULTS: We did not find positive associations between any long-term traffic-related exposure and onset of doctor-diagnosed asthma. An interquartile range (IQR) increase of NO(2) exposure before asthma onset was associated with an adjusted risk ratio of 0.82 [95% confidence interval (CI), 0.67-1.02]. Handling early asthma cases (children 4 years of age) with recovery during follow-up as noncases gave a less negative association. The associations for late asthma onset (/= 4 years of age) were positive but not statistically significant. For current symptoms, an IQR increase of previous year's NO(2) exposure was associated with adjusted odds ratios of 1.01 (95% CI, 0.83-1.23) for wheeze, 1.10 (95% CI, 0.79-1.51) for severe wheeze, and 1.01 (95% CI, 0.84-1.21) for dry cough. CONCLUSIONS: We were not able to find positive associations of long-term traffic-related exposures with asthma onset or with current respiratory symptoms in 9- to 10-year-old children in Oslo. JF - Environmental Health Perspectives AU - Oftedal, Bente AU - Nystad, Wenche AU - Brunekreef, Bert AU - Nafstad, Per PY - 2009 SP - 839 EP - 844 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Exposure KW - Asthma KW - Children KW - Mathematical models KW - Regression KW - Health KW - Age KW - Adjustment KW - Materials handling KW - Assessments KW - Nitrogen dioxide KW - Dispersions KW - Risk KW - Traffic flow KW - Drying KW - Traffic engineering KW - Roads KW - Cough KW - Confidence intervals KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743263957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Long-Term+Traffic-Related+Exposures+and+Asthma+Onset+in+Schoolchildren+in+Oslo%2C+Norway&rft.au=Oftedal%2C+Bente%3BNystad%2C+Wenche%3BBrunekreef%2C+Bert%3BNafstad%2C+Per&rft.aulast=Oftedal&rft.aufirst=Bente&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Hexavalent Chromium Is Carcinogenic to F344/N Rats and B6C3F1 Mice after Chronic Oral Exposure AN - 743244895; 201004-31-0310513 (CE); 12115939 (EN) AB - BACKGROUND: Hexavalent chromium [Cr(VI)] is a human carcinogen after inhalation exposure. Humans also ingest Cr(VI) from contaminated drinking water and soil; however, limited data exist on the oral toxicity and carcinogenicity of Cr(VI). OBJECTIVE: We characterized the chronic oral toxicity and carcinogenicity of Cr(VI) in rodents. METHODS: The National Toxicology Program (NTP) conducted 2-year drinking water studies of Cr(VI) (as sodium dichromate dihydrate) in male and female F344/N rats and B6C3F1 mice. RESULTS: Cr(VI) exposure resulted in increased incidences of rare neoplasms of the squamous epithelium that lines the oral cavity (oral mucosa and tongue) in male and female rats, and of the epithelium lining the small intestine in male and female mice. Cr(VI) exposure did not affect survival but resulted in reduced mean body weights and water consumption, due at least in part to poor palatability of the dosed water. Cr(VI) exposure resulted in transient microcytic hypochromic anemia in rats and microcytosis in mice. Nonneoplastic lesions included diffuse epithelial hyperplasia in the duodenum and jejunum of mice and histiocytic cell infiltration in the duodenum, liver, and mesenteric and pancreatic lymph nodes of rats and mice. CONCLUSIONS: Cr(VI) was carcinogenic after administration in drinking water to male and female rats and mice. JF - Environmental Health Perspectives AU - Stout, Matthew D AU - Herbert, Ronald A AU - Kissling, Grace E AU - Collins, Bradley J AU - Travlos, Gregory S AU - Witt, Kristine L AU - Melnick, Ronald L AU - Abdo, Kamal M AU - Malarkey, David E AU - Hooth, Michelle J PY - 2009 SP - 716 EP - 722 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mice KW - Rats KW - Males KW - Females KW - Carcinogens KW - Drinking water KW - Toxicity KW - Carcinogenicity KW - Health KW - Hexavalent chromium KW - Epithelium KW - Human KW - Sodium KW - Lymph KW - Infiltration KW - Water consumption KW - Chromates KW - Diffusion KW - Neoplasms KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743244895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Hexavalent+Chromium+Is+Carcinogenic+to+F344%2FN+Rats+and+B6C3F1+Mice+after+Chronic+Oral+Exposure&rft.au=Stout%2C+Matthew+D%3BHerbert%2C+Ronald+A%3BKissling%2C+Grace+E%3BCollins%2C+Bradley+J%3BTravlos%2C+Gregory+S%3BWitt%2C+Kristine+L%3BMelnick%2C+Ronald+L%3BAbdo%2C+Kamal+M%3BMalarkey%2C+David+E%3BHooth%2C+Michelle+J&rft.aulast=Stout&rft.aufirst=Matthew&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=716&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Global Screening of Human Cord Blood Proteomes for Biomarkers of Toxic Exposure and Effect AN - 743212644; 201004-31-0310497 (CE); 12115923 (EN) AB - BACKGROUND: Exposures of pregnant women to natural and manmade chemicals can lead to negative health effects in the baby, ranging from low birth weight to developmental defects. In some cases, diseases were postulated to have their basis in toxic exposure in utero or in early childhood. Therefore, an understanding of fetal responses to environmental exposures is essential. To that end, cord blood is a readily accessible biofluid whose proteomic makeup remains mostly unexplored when compared with that of adults. OBJECTIVES: Our goal was an initial global assessment of the fetal serum proteome and for the identification of protein biomarkers indicative of toxic in utero exposures related to maternal cigarette smoking. METHODS: Drawing from a repository of 300 samples, we selected umbilical cord blood sera from 12 babies born to six smokers and six nonsmokers and analyzed both sample pools by tandem mass spectrometry in conjunction with isobaric tags (iTRAQ) for protein quantification. RESULTS: We identified 203 proteins, 17 of which were differentially expressed between the cigarette smoke-exposed and control populations. Most of the identified candidate biomarkers were biologically plausible, thereby underscoring the feasibility of screening neonates with global proteomic techniques for biomarkers of exposure and early biological effects triggered by in utero chemical exposures. CONCLUSIONS: This validation study provides an initial view of the proteome of human cord blood sera; it demonstrates the feasibility of identifying therein by use of proteomics, biomarkers of environmental, toxic exposures. JF - Environmental Health Perspectives AU - Colquhoun, David R AU - Goldman, Lynn R AU - Cole, Robert N AU - Gucek, Marjan AU - Mansharamani, Malini AU - Witter, Frank R AU - Apelberg, Benjamin J AU - Halden, Rolf U PY - 2009 SP - 832 EP - 838 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Toxic KW - Blood KW - Biological effects KW - Toxicology KW - Health KW - Rope KW - Proteomics KW - Proteins KW - Cigarettes KW - Feasibility KW - Human KW - Babies KW - Screening KW - Assessments KW - Diseases KW - Adults KW - Repositories KW - Populations KW - Mass spectrometry KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743212644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Global+Screening+of+Human+Cord+Blood+Proteomes+for+Biomarkers+of+Toxic+Exposure+and+Effect&rft.au=Colquhoun%2C+David+R%3BGoldman%2C+Lynn+R%3BCole%2C+Robert+N%3BGucek%2C+Marjan%3BMansharamani%2C+Malini%3BWitter%2C+Frank+R%3BApelberg%2C+Benjamin+J%3BHalden%2C+Rolf+U&rft.aulast=Colquhoun&rft.aufirst=David&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Folate, Cobalamin, Cysteine, Homocysteine, and Arsenic Metabolism among Children in Bangladesh AN - 743194988; 201004-31-0310498 (CE); 12115924 (EN) AB - BACKGROUND: Approximately 35 million people in Bangladesh are chronically exposed to inorganic arsenic (InAs) in drinking water. Methylation of InAs to monomethylarsonic (MMA) and dimethylarsinic acids (DMA) relies on folate-dependent one-carbon metabolism and facilitates urinary arsenic (uAs) elimination. OBJECTIVES: We examined the relationships between folate, cobalamin, cysteine, total homocysteine (tHcys), and uAs metabolites in a sample of 6-year-old Bangladeshi children (n = 165). METHODS: Children provided blood samples for measurement of tHcys, folate, cobalamin, and cysteine, and urine specimens for the measurement of total uAs and As metabolites. RESULTS: Consistent with our studies in adults, mean tHcys concentrations (7.9 micromol/L) were higher than those reported among children of similar ages in other populations. Nineteen percent of the children had plasma folate concentrations 9.0 nmol/L. The proportion of total uAs excreted as InAs (%InAs) was inversely correlated with folate (r = -0.20, p = 0.01) and cysteine (r = -0.23, p = 0.003), whereas the correlations between %DMA and both folate (r = 0.12, p = 0.14) and cysteine (r = 0.11, p = 0.15) were positive. Homocysteine was inversely correlated (r = -0.27, p = 0.009) with %MMA in males, and the correlation with %DMA was positive (r = 0.13, p = 0.10). CONCLUSIONS: These findings suggest that, similar to adults, folate and cysteine facilitate As methylation in children. However, the inverse correlation between tHcys and %MMA, and positive correlation with %DMA, are both opposite to our previous findings in adults. We propose that upregulation of one-carbon metabolism, presumably necessary to meet the considerable demands for DNA and protein biosynthesis during periods of rapid growth, results in both increased tHcys biosynthesis and increased As methylation. JF - Environmental Health Perspectives AU - Hall, Megan N AU - Liu, Xinhua AU - Slavkovich, Vesna AU - Ilievski, Vesna AU - Pilsner, J Richard AU - Alam, Shafiul AU - Factor-Litvak, Pam AU - Graziano, Joseph H AU - Gamble, Mary V PY - 2009 SP - 825 EP - 831 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Correlation KW - Cysteine KW - Indium arsenides KW - Polymethyl methacrylates KW - Adults KW - Methylation KW - Metabolism KW - Arsenic KW - Metabolites KW - Health KW - Biosynthesis KW - Rapids KW - Drinking water KW - Demand KW - Populations KW - Males KW - Copyrights KW - Marketing KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743194988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Folate%2C+Cobalamin%2C+Cysteine%2C+Homocysteine%2C+and+Arsenic+Metabolism+among+Children+in+Bangladesh&rft.au=Hall%2C+Megan+N%3BLiu%2C+Xinhua%3BSlavkovich%2C+Vesna%3BIlievski%2C+Vesna%3BPilsner%2C+J+Richard%3BAlam%2C+Shafiul%3BFactor-Litvak%2C+Pam%3BGraziano%2C+Joseph+H%3BGamble%2C+Mary+V&rft.aulast=Hall&rft.aufirst=Megan&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Characterization of the Chronic Risk and Hazard of Hazardous Air Pollutants in the United States Using Ambient Monitoring Data AN - 743121433; 201004-31-0310503 (CE); 12115929 (EN) AB - BACKGROUND: Ambient measurements of hazardous air pollutants (air toxics) have been used to validate model-predicted concentrations of air toxics but have not been used to perform risk screening at the national level. OBJECTIVES: We used ambient concentrations of routinely measured air toxics to determine the relative importance of individual air toxics for chronic cancer and noncancer exposures. METHODS: We compiled 3-year averages for ambient measurement of air toxics collected at monitoring locations in the United States from 2003 through 2005. We then used national distributions of risk-weighted concentrations to identify the air toxics of most concern. RESULTS: Concentrations of benzene, carbon tetrachloride, arsenic, 1,3-butadiene, and acetaldehyde were above the 10(-6) cancer risk level at most sites nationally with a high degree of confidence. Concentrations of tetrachloroethylene, ethylene oxide, acrylonitrile, and 1,4-dichlorobenzene were also often greater than the 10(-6) cancer risk level, but we have less confidence in the estimated risk associated with these pollutants. Formaldehyde and chromium VI concentrations were either above or below the 10(-6) cancer risk level, depending on the choice of agency-recommended 10(-6) level. The method detection limits of eight additional pollutants were too high to rule out that concentrations were above the 10(-6) cancer risk level. Concentrations of 52 compounds compared with chronic noncancer benchmarks indicated that only acrolein concentrations were greater than the noncancer reference concentration at most monitoring sites. CONCLUSIONS: Most pollutants with national site-level averages greater than health benchmarks were also pollutants of concern identified in modeled national-scale risk assessments. Current monitoring networks need more sensitive ambient measurement techniques to better characterize the air toxics problem in the United States. JF - Environmental Health Perspectives AU - McCarthy, Michael C AU - O'Brien, Theresa E AU - Charrier, Jessica G AU - Hafner, Hilary R PY - 2009 SP - 790 EP - 796 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Toxic KW - Toxicology KW - Pollutants KW - Cancer KW - Risk levels KW - Monitoring KW - Risk KW - Health KW - Chromium KW - Mathematical models KW - Hazardous KW - Benchmarks KW - Confidence KW - Combustion KW - Networks KW - Acroleins KW - Tetrachloroethylene KW - Hazards KW - Copyrights KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743121433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Characterization+of+the+Chronic+Risk+and+Hazard+of+Hazardous+Air+Pollutants+in+the+United+States+Using+Ambient+Monitoring+Data&rft.au=McCarthy%2C+Michael+C%3BO%27Brien%2C+Theresa+E%3BCharrier%2C+Jessica+G%3BHafner%2C+Hilary+R&rft.aulast=McCarthy&rft.aufirst=Michael&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=790&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Cohort Study of Traffic-Related Air Pollution and Mortality in Toronto, Ontario, Canada AN - 743120561; 201004-31-0310505 (CE); 12115931 (EN) AB - BACKGROUND: Chronic exposure to traffic-related air pollution (TRAP) may contribute to premature mortality, but few studies to date have addressed this topic. OBJECTIVES: In this study we assessed the association between TRAP and mortality in Toronto, Ontario, Canada. METHODS: We collected nitrogen dioxide samples over two seasons using duplicate two-sided Ogawa passive diffusion samplers at 143 locations across Toronto. We calibrated land use regressions to predict NO2 exposure on a fine scale within Toronto. We used interpolations to predict levels of particulate matter with aerodynamic diameter or = 2.5 microm (PM(2.5)) and ozone levels. We assigned predicted pollution exposures to 2,360 subjects from a respiratory clinic, and abstracted health data on these subjects from medical billings, lung function tests, and diagnoses by pulmonologists. We tracked mortality between 1992 and 2002. We used standard and multilevel Cox proportional hazard models to test associations between air pollution and mortality. RESULTS: After controlling for age, sex, lung function, obesity, smoking, and neighborhood deprivation, we observed a 17% increase in all-cause mortality and a 40% increase in circulatory mortality from an exposure contrast across the interquartile range of 4 ppb NO2. We observed no significant associations with other pollutants. CONCLUSIONS: Exposure to TRAP was significantly associated with increased all-cause and circulatory mortality in this cohort. A high prevalence of cardiopulmonary disease in the cohort probably limits inference of the findings to populations with a substantial proportion of susceptible individuals. JF - Environmental Health Perspectives AU - Jerrett, Michael AU - Finkelstein, Murray M AU - Brook, Jeffrey R AU - Arain, M Altaf AU - Kanaroglou, Palvos AU - Stieb, Dave M AU - Gilbert, Nicolas L AU - Verma, Dave AU - Finkelstein, Norm AU - Chapman, Kenneth R AU - Sears, Malcolm R PY - 2009 SP - 772 EP - 777 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mortality KW - Air pollution KW - Mathematical models KW - Nitrogen dioxide KW - Health KW - Circulation KW - Lungs KW - Reproduction KW - Inference KW - Disease control KW - Medical KW - Populations KW - Land use KW - Diffusion KW - Seasons KW - Norms KW - Standards KW - Hazards KW - Multilevel KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743120561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Cohort+Study+of+Traffic-Related+Air+Pollution+and+Mortality+in+Toronto%2C+Ontario%2C+Canada&rft.au=Jerrett%2C+Michael%3BFinkelstein%2C+Murray+M%3BBrook%2C+Jeffrey+R%3BArain%2C+M+Altaf%3BKanaroglou%2C+Palvos%3BStieb%2C+Dave+M%3BGilbert%2C+Nicolas+L%3BVerma%2C+Dave%3BFinkelstein%2C+Norm%3BChapman%2C+Kenneth+R%3BSears%2C+Malcolm+R&rft.aulast=Jerrett&rft.aufirst=Michael&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=772&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Children's Environmental Health Faculty Champions Initiative: A Successful Model for Integrating Environmental Health into Pediatric Health Care AN - 743115981; 201004-31-0310494 (CE); 12115920 (EN) AB - BACKGROUND: Pediatric medical and nursing education lack the environmental health content needed to properly prepare health care professionals to prevent, recognize, manage, and treat environmental exposure-related diseases. The need for improvements in health care professionals' environmental health knowledge has been expressed by leading institutions. However, few studies have evaluated the effectiveness of programs that incorporate pediatric environmental health (PEH) into curricula and practice. OBJECTIVE: We evaluated the effectiveness of the National Environmental Education Foundation's (NEEF) Children's Environmental Health Faculty Champions Initiative, which is designed to build environmental health capacity among pediatric health care professionals. METHODS: Twenty-eight pediatric health care professionals participated in a train-the-trainer workshop, in which they were educated to train other health care professionals in PEH and integrate identified PEH competencies into medical and nursing practice and curricula. We evaluated the program using a workshop evaluation tool, action plan, pre- and posttests, baseline and progress assessments, and telephone interviews. RESULTS: During the 12 months following the workshop, the faculty champions' average pretest score of 52% was significantly elevated (p 0.0001) to 65.5% on the first posttest and to 71.5% on the second posttest, showing an increase and retention of environmental health knowledge. Faculty champions trained 1,559 health care professionals in PEH, exceeding the goal of 280 health care professionals trained. Ninety percent of faculty champions reported that PEH had been integrated into the curricula at their institution. CONCLUSION: The initiative was highly effective in achieving its goal of building environmental health capacity among health care professionals. The faculty champions model is a successful method and can be replicated in other arenas. JF - Environmental Health Perspectives AU - Rogers, Bonnie AU - McCurdy, Leyla AU - Slavin, Katie AU - Grubb, Kimberly AU - Roberts, James R PY - 2009 SP - 850 EP - 855 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Health care KW - Education KW - Workshops KW - Nurses KW - Medical KW - Children KW - Mathematical models KW - Construction KW - Trains KW - Assessments KW - Tools KW - Arenas KW - Diseases KW - Elevated KW - Telephones KW - Copyrights KW - Exposure KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743115981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Children%27s+Environmental+Health+Faculty+Champions+Initiative%3A+A+Successful+Model+for+Integrating+Environmental+Health+into+Pediatric+Health+Care&rft.au=Rogers%2C+Bonnie%3BMcCurdy%2C+Leyla%3BSlavin%2C+Katie%3BGrubb%2C+Kimberly%3BRoberts%2C+James+R&rft.aulast=Rogers&rft.aufirst=Bonnie&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=850&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Bisphenol A Data in NHANES Suggest Longer than Expected Half-Life, Substantial Nonfood Exposure, or Both AN - 743106454; 201004-31-0310504 (CE); 12115930 (EN) AB - BACKGROUND: It is commonly stated in the literature on human exposure to bisphenol A (BPA) that food is the predominant BPA exposure source, and that BPA is rapidly and completely cleared from the body. If this is correct, BPA levels in fasting individuals should decrease with increased fasting time. OBJECTIVES: We set out to investigate the relationship between urine BPA concentration and fasting time in a population-based sample. METHODS: We modeled log BPA urine concentration as a function of fasting time, adjusted for urine creatinine and other confounders, in 1,469 adult participants in the 2003-2004 National Health and Nutrition Examination Survey. We estimated the BPA "population-based half-life" (pop(1/2)) for a fasting time of 0-24 hr, 4.5 hr, 4.5-8.5 hr, and 8.5 hr. RESULTS: The overall pop(1/2) for the 0- to 24-hr interval was 43 hr [95% confidence interval (CI), 26-119 hr]. Among those reporting fasting times of 4.5-8.5 hr (n = 441), BPA declined significantly with fasting time, with a pop(1/2) of 4.1 hr (95% CI, 2.6-10.6 hr). However, within the fasting time intervals of 0-4.5 hr (n = 129) and 8.5-24 hr (n = 899), we saw no appreciable decline. Fasting time did not significantly predict highest ( 12 ng/mL) or lowest (below limit of detection) BPA levels. CONCLUSIONS: Overall, BPA levels did not decline rapidly with fasting time in this sample. This suggests substantial nonfood exposure, accumulation in body tissues such as fat, or both. Explaining these findings may require experimental pharmacokinetic studies of chronic BPA exposure, further examination of BPA levels and effects in fat, and a search for important nonfood sources. JF - Environmental Health Perspectives AU - Stahlhut, Richard W AU - Welshons, Wade V AU - Swan, Shanna H PY - 2009 SP - 784 EP - 789 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Fasting KW - Health KW - Mathematical models KW - Urine KW - Bisphenol A KW - Intervals KW - Steels KW - Searching KW - Nutrition KW - Adults KW - Reporting KW - Confidence intervals KW - Copyrights KW - Foods KW - Creatinine KW - Human KW - Tissues (biology) KW - Adjustment KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743106454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Bisphenol+A+Data+in+NHANES+Suggest+Longer+than+Expected+Half-Life%2C+Substantial+Nonfood+Exposure%2C+or+Both&rft.au=Stahlhut%2C+Richard+W%3BWelshons%2C+Wade+V%3BSwan%2C+Shanna+H&rft.aulast=Stahlhut&rft.aufirst=Richard&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=784&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Differential Regulation of Dopamine Transporter Function and Location by Low Concentrations of Environmental Estrogens and 17[beta]-Estradiol AN - 743082157; 201004-31-0310428 (CE); 12115503 (EN) AB - BACKGROUND: The effects of 17beta-estradiol (E2) and xenoestrogens (XEs) on dopamine transport may have important implications for the increased incidence of neurologic disorders, especially in women during life stages characterized by frequent hormonal fluctuations. OBJECTIVE: We examined low concentrations of XEs [dieldrin, endosulfan, o', p'-dichlorodiphenyl-ethylene (DDE), nonylphenol (NP), and bisphenol A (BPA)] for nongenomic actions via action of membrane estrogen receptors (ERs). METHODS: We measured activity of the dopamine transporter (DAT) by the efflux of 3H-dopamine in nontransfected nerve growth factor-differentiated PC12 rat pheochromocytoma cells expressing membrane DAT, ER-alpha, ER-beta, and G-protein-coupled receptor 30. We used a plate immunoassay to monitor trafficking of these proteins. RESULTS: All compounds at 1 nM either caused efflux or inhibited efflux, or both; each compound evoked a distinct oscillatory pattern. At optimal times for each effect, we examined different concentrations of XEs. All XEs were active at some concentration 10 nM, and dose responses were all nonmonotonic. For example, 10(-14) to 10(-11) M DDE caused significant efflux inhibition, whereas NP and BPA enhanced or inhibited efflux at several concentrations. We also measured the effects of E2/XE combinations; DDE potentiated E(2)-mediated dopamine efflux, whereas BPA inhibited it. In E2-induced efflux, 15% more ER-alpha trafficked to the membrane, whereas ER-beta waned; during BPA-induced efflux, 20% more DAT was trafficked to the plasma membrane. CONCLUSIONS: Low levels of environmental estrogen contaminants acting as endocrine disruptors via membrane ERs can alter dopamine efflux temporal patterning and the trafficking of DAT and membrane ERs, providing a cellular mechanism that could explain the disruption of physiologic neurotransmitter function. JF - Environmental Health Perspectives AU - Alyea, Rebecca A AU - Watson, Cheryl S PY - 2009 SP - 778 EP - 783 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 5 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Efflux KW - Membranes KW - Dopamine KW - Estrogens KW - Transporter KW - Low concentrations KW - Health KW - Receptors KW - Neurotransmitters KW - Bisphenol A KW - Cellular KW - Monitors KW - Position (location) KW - Patterning KW - Contaminants KW - Disorders KW - Endocrine disruptors KW - Low level KW - Inhibition KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743082157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Differential+Regulation+of+Dopamine+Transporter+Function+and+Location+by+Low+Concentrations+of+Environmental+Estrogens+and+17%5Bbeta%5D-Estradiol&rft.au=Alyea%2C+Rebecca+A%3BWatson%2C+Cheryl+S&rft.aulast=Alyea&rft.aufirst=Rebecca&rft.date=2009-05-01&rft.volume=117&rft.issue=5&rft.spage=778&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Dietary meat intake in relation to colorectal adenoma in asymptomatic women. AN - 742781870; pmid-19367270 AB - OBJECTIVES: No previous study has concurrently assessed the associations between meat intake, meat-cooking methods and doneness levels, meat mutagens (heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons), heme iron, and nitrite from meat and colorectal adenoma in asymptomatic women undergoing colonoscopy. METHODS: Of the 807 eligible women in a cross-sectional multicenter colonoscopy screening study, 158 prevalent colorectal adenoma cases and 649 controls satisfactorily completed the validated food frequency and meat questionnaires. Using an established meat mutagen database and new heme iron and nitrite databases, we comprehensively investigated the components of meat that may be involved in carcinogenesis. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) within quartiles of meat-related variables. RESULTS: Red meat was associated positively with colorectal adenoma (OR fourth vs. first quartile = 2.02; 95% CI = 1.06-3.83; P trend = 0.38). Intake of pan-fried meat (OR = 1.72; 95% CI = 0.96-3.07; P trend = 0.01) and the HCA: 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) (OR = 1.90; 95% CI = 1.05-3.42; P trend = 0.07) were also associated with an increased risk of colorectal adenoma. The new databases yielded lower estimates of heme iron and nitrite than previous assessment methods, although the two methods were highly correlated for both exposures. Although not statistically significant, there were positive associations between iron and heme iron from meat and colorectal adenoma. CONCLUSIONS: In asymptomatic women undergoing colonoscopy, colorectal adenomas were associated with high intake of red meat, pan-fried meat, and the HCA MeIQx. Other meat-related exposures require further investigation. JF - The American journal of gastroenterology AU - Ferrucci, Leah M AU - Sinha, Rashmi AU - Graubard, Barry I AU - Mayne, Susan T AU - Ma, Xiaomei AU - Schatzkin, Arthur AU - Schoenfeld, Philip S AU - Cash, Brooks D AU - Flood, Andrew AU - Cross, Amanda J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. ferruccil@mail.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1231 EP - 1240 VL - 104 IS - 5 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Colorectal Neoplasms -- diagnosis KW - Reference Values KW - Odds Ratio KW - Cookery KW - Humans KW - Aged KW - Mass Screening -- methods KW - Colonoscopy -- methods KW - Diet -- adverse effects KW - Risk Assessment KW - Multivariate Analysis KW - Cross-Sectional Studies KW - Logistic Models KW - Adult KW - Adenoma -- epidemiology KW - Colorectal Neoplasms -- etiology KW - Adenoma -- etiology KW - Confidence Intervals KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Colorectal Neoplasms -- epidemiology KW - Adenoma -- diagnosis KW - Female KW - Meat Products -- adverse effects KW - Heterocyclic Compounds -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742781870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Dietary+meat+intake+in+relation+to+colorectal+adenoma+in+asymptomatic+women.&rft.au=Ferrucci%2C+Leah+M%3BSinha%2C+Rashmi%3BGraubard%2C+Barry+I%3BMayne%2C+Susan+T%3BMa%2C+Xiaomei%3BSchatzkin%2C+Arthur%3BSchoenfeld%2C+Philip+S%3BCash%2C+Brooks+D%3BFlood%2C+Andrew%3BCross%2C+Amanda+J&rft.aulast=Ferrucci&rft.aufirst=Leah&rft.date=2009-05-01&rft.volume=104&rft.issue=5&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-07-08 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Results of the National Institute for Occupational Safety and Health-U.S. Environmental Protection Agency interlaboratory comparison of American National Standards Institute S12.6-1997 Methods A and B. AN - 742778841; pmid-19425669 AB - The National Institute for Occupational Safety and Health and the Environmental Protection Agency sponsored the completion of an interlaboratory study to compare two fitting protocols specified by ANSI S12.6-1997 (R2002) [(2002). American National Standard Methods for the Measuring Real-Ear Attenuation of Hearing Protectors, American National Standards Institute, New York]. Six hearing protection devices (two earmuffs, foam, premolded, custom-molded earplugs, and canal-caps) were tested in six laboratories using the experimenter-supervised, Method A, and (naive) subject-fit, Method B, protocols with 24 subjects per laboratory. Within-subject, between-subject, and between-laboratory standard deviations were determined for individual frequencies and A-weighted attenuations. The differences for the within-subject standard deviations were not statistically significant between Methods A and B. Using between-subject standard deviations from Method A, 3-12 subjects would be required to identify 6-dB differences between attenuation distributions. Whereas using between-subject standard deviations from Method B, 5-19 subjects would be required to identify 6-dB differences in attenuation distributions of a product tested within the same laboratory. However, the between-laboratory standard deviations for Method B were -0.1 to 3.0 dB less than the Method A results. These differences resulted in considerably more subjects being required to identify statistically significant differences between laboratories for Method A (12-132 subjects) than for Method B (9-28 subjects). JF - The Journal of the Acoustical Society of America AU - Murphy, William J AU - Byrne, David C AU - Gauger, Dan AU - Ahroon, William A AU - Berger, Elliott AU - Gerges, Samir N Y AU - McKinley, Richard AU - Witt, Brad AU - Krieg, Edward F AD - Hearing Loss Prevention Team, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-27, Cincinnati, Ohio 45226-1998, USA. wmurphy@cdc.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 3262 EP - 3277 VL - 125 IS - 5 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - United States KW - United States Environmental Protection Agency -- legislation & jurisprudence KW - Analysis of Variance KW - Reproducibility of Results KW - Auditory Threshold KW - Humans KW - Prosthesis Fitting -- methods KW - Algorithms KW - Ear Canal -- anatomy & histology KW - Anthropometry KW - Head -- anatomy & histology KW - Hearing KW - Male KW - Female KW - Ear Protective Devices KW - Guidelines as Topic KW - National Institute for Occupational Safety and Health (U.S.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742778841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Results+of+the+National+Institute+for+Occupational+Safety+and+Health-U.S.+Environmental+Protection+Agency+interlaboratory+comparison+of+American+National+Standards+Institute+S12.6-1997+Methods+A+and+B.&rft.au=Murphy%2C+William+J%3BByrne%2C+David+C%3BGauger%2C+Dan%3BAhroon%2C+William+A%3BBerger%2C+Elliott%3BGerges%2C+Samir+N+Y%3BMcKinley%2C+Richard%3BWitt%2C+Brad%3BKrieg%2C+Edward+F&rft.aulast=Murphy&rft.aufirst=William&rft.date=2009-05-01&rft.volume=125&rft.issue=5&rft.spage=3262&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Looking back to the future: from the development of the gene concept to toxicogenomics. AN - 67669088; 19778216 AB - Initial progress in the science of 'genetics' in the first half of the 20th century was mainly driven by studies utilizing mutations and consequent changes in phenotype. The structural and functional nature of the gene was far from being understood. That state of understanding started changing from the 1940s. In the following decades, with the discovery of the double helix followed by the discoveries on gene structure and expression, there was a period when the structural and functional aspects of the gene could be conceived in terms of one entity, the cistron. However, the discovery of intervening sequences caused this unified concept to fall apart, making the gene concept a subject of philosophical debate again. Meanwhile, over time, technological progress in molecular biology had the field forge ahead rapidly, ultimately leading to the sequencing of the human genome and genomes of other species, and giving birth to the science of genomics. Developments in genomics have given rise to certain applied sub-disciplines like pharmacogenomics and toxicogenomics. While the full potential of pharmaco- and toxicogenomics is yet to be harnessed, they nevertheless have had an impact in drug development and safety assessment, such that the future promise of genomics seems achievable. At present, it is a good opportunity to revisit the path from the development of the initial gene concept and the philosophical debate surrounding the meaning of the term 'gene' to the current state of understanding of genes and genomes and their role in health and disease. JF - Toxicology mechanisms and methods AU - Choudhuri, Supratim AD - US Food and Drug Administration, Division of Biotechnology and GRAS Notice Review, Center for Food Safety and Applied Nutrition, MD, USA. choudhuri@fda.hhs.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 263 EP - 277 VL - 19 IS - 4 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - United States KW - Molecular Biology -- history KW - Animals KW - History, 21st Century KW - History, 20th Century KW - Genome, Human KW - Genes KW - Human Genome Project KW - Humans KW - History, 19th Century KW - Genetics -- history KW - DNA -- history KW - Toxicogenetics -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67669088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=Looking+back+to+the+future%3A+from+the+development+of+the+gene+concept+to+toxicogenomics.&rft.au=Choudhuri%2C+Supratim&rft.aulast=Choudhuri&rft.aufirst=Supratim&rft.date=2009-05-01&rft.volume=19&rft.issue=4&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.1080%2F15376510902855529 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15376510902855529 ER - TY - JOUR T1 - Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice. AN - 67573079; 19214943 AB - Three new saponins, bacopasides IX-XI (1- 3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice. Copyright Georg Thieme Verlag KG Stuttgart. New York. JF - Planta medica AU - Zhou, Yun AU - Peng, Ling AU - Zhang, Wei-Dong AU - Kong, De-Yun AD - Zhejiang Food and Drug Administration, Hangzhou 310012, Zhejiang Province, PR China. yunzhoucn@yahoo.com.cn Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 568 EP - 574 VL - 75 IS - 6 KW - Nootropic Agents KW - 0 KW - Plant Extracts KW - Triterpenes KW - bacopaside IX KW - bacopaside X KW - bacopaside XI KW - Scopolamine Hydrobromide KW - 451IFR0GXB KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Memory -- drug effects KW - Disease Models, Animal KW - Mice KW - Male KW - Bacopa -- chemistry KW - Phytotherapy KW - Plant Extracts -- isolation & purification KW - Triterpenes -- pharmacology KW - Nootropic Agents -- pharmacology KW - Triterpenes -- isolation & purification KW - Plant Extracts -- pharmacology KW - Memory Disorders -- chemically induced KW - Nootropic Agents -- isolation & purification KW - Triterpenes -- chemistry KW - Plant Extracts -- therapeutic use KW - Nootropic Agents -- therapeutic use KW - Memory Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67573079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Planta+medica&rft.atitle=Effect+of+triterpenoid+saponins+from+Bacopa+monniera+on+scopolamine-induced+memory+impairment+in+mice.&rft.au=Zhou%2C+Yun%3BPeng%2C+Ling%3BZhang%2C+Wei-Dong%3BKong%2C+De-Yun&rft.aulast=Zhou&rft.aufirst=Yun&rft.date=2009-05-01&rft.volume=75&rft.issue=6&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Planta+medica&rft.issn=1439-0221&rft_id=info:doi/10.1055%2Fs-0029-1185339 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-06 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1055/s-0029-1185339 ER - TY - JOUR T1 - Concurrent use of statins and amiodarone. AN - 67422544; 19555146 AB - To estimate the concurrent use between statins and amiodarone in context with published case reports of drug-interaction-induced rhabdomyolysis. Retrospective analysis of a longitudinal prescription claims database for concurrent prescriptions of statins and amiodarone dispensed during 2006. The study population includes an unprojected annual number of patients who filled a prescription for an HMG CoA reductase inhibitor or simvastatin-containing products or lovastatin-containing products or Lipitor (atorvastatin) or Caduet (amlodipine/atorvastatin) concurrently with brand and generic forms of amiodarone during 2006. The concurrency analysis was used to provide context for published case reports of rhabdomyolysis/myopathy related to simvastatin and amiodarone concurrent use. Episodes of concurrent use between statins and amiodarone. Findings from this analysis indicate noteworthy amiodarone and statin concurrency (44%) when based on amiodarone patient volume. Atorvastatin had the greatest level of concurrency (23.5%) with amiodarone followed by simvastatin (13.3%). Proportionality based on amiodarone patient volume shows a greater level of concurrency with 20 mg (6%) and 40 mg (5.5%) simvastatin strengths compared with other simvastatin strengths. Clinicians should be vigilant in monitoring the regimens of patients prescribed a statin with drugs that may increase the risk of myopathy. In particular, since nearly half of the patients prescribed amiodarone may also be prescribed a statin, then addition of amiodarone or changes in statin dose should trigger a drug regimen review and patient level monitoring. Clinicians should avoid simvastatin doses greater than 20 mg per day in patients taking amiodarone. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Borders-Hemphill, Vicky AD - Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Division of Epidemiology, Silver Spring, Maryland 20903, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 372 EP - 379 VL - 24 IS - 5 SN - 0888-5109, 0888-5109 KW - Anti-Arrhythmia Agents KW - 0 KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Amiodarone KW - N3RQ532IUT KW - Index Medicus KW - Drug Interactions KW - Humans KW - Drug Monitoring KW - Retrospective Studies KW - Databases, Factual KW - Aged KW - Middle Aged KW - Longitudinal Studies KW - Male KW - Female KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacokinetics KW - Rhabdomyolysis -- chemically induced KW - Amiodarone -- adverse effects KW - Anti-Arrhythmia Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67422544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=Concurrent+use+of+statins+and+amiodarone.&rft.au=Borders-Hemphill%2C+Vicky&rft.aulast=Borders-Hemphill&rft.aufirst=Vicky&rft.date=2009-05-01&rft.volume=24&rft.issue=5&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chlorine dioxide gas from an aqueous solution: reduction of Salmonella in wounds on tomato fruit and movement to sinks in a treatment chamber. AN - 67350836; 19517720 AB - Chlorine dioxide (ClO2) off-gassed from an aqueous solution and reacted incrementally with potassium iodide solutions (sinks). After 30 min, 45% of the initial dose was detected as chlorite ion in the sink, whereas 35% of the initial dose was still in the source. Aqueous solutions of ClO2 can be used as a source of ClO2 gas in various laboratory experiments involving treatment of fruits or vegetables. Movement from source to sink is continuous, which precludes the development of large headspace concentrations and the need for a tight chamber seal. When the source solution has dissipated, the chamber can be opened safely as there is little free ClO2 remaining in the headspace. In tests with whole, wound-inoculated tomato fruit, at both green and pink stages of ripeness, the control of Salmonella enterica serotype Typhimurium in wounds varied with the weight of gas used. The number of viable cells of Typhimurium recovered was reduced by > 5 log units when > or = 0.5 mg of ClO2 was applied to three pieces of fruit during a 2-h treatment. JF - Journal of food protection AU - Mahovic, Michael AU - Bartz, Jerry A AU - Schneider, Keith R AU - Tenney, Joel D AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, Maryland, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 952 EP - 958 VL - 72 IS - 5 SN - 0362-028X, 0362-028X KW - Anti-Infective Agents, Local KW - 0 KW - Chlorine Compounds KW - Oxides KW - Potassium Iodide KW - 1C4QK22F9J KW - chlorine dioxide KW - 8061YMS4RM KW - Index Medicus KW - Food Microbiology KW - Consumer Product Safety KW - Humans KW - Colony Count, Microbial KW - Potassium Iodide -- pharmacology KW - Chlorine Compounds -- pharmacology KW - Anti-Infective Agents, Local -- pharmacology KW - Food Handling -- methods KW - Lycopersicon esculentum -- microbiology KW - Salmonella typhimurium -- drug effects KW - Oxides -- pharmacology KW - Salmonella typhimurium -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67350836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Chlorine+dioxide+gas+from+an+aqueous+solution%3A+reduction+of+Salmonella+in+wounds+on+tomato+fruit+and+movement+to+sinks+in+a+treatment+chamber.&rft.au=Mahovic%2C+Michael%3BBartz%2C+Jerry+A%3BSchneider%2C+Keith+R%3BTenney%2C+Joel+D&rft.aulast=Mahovic&rft.aufirst=Michael&rft.date=2009-05-01&rft.volume=72&rft.issue=5&rft.spage=952&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-09 N1 - Date created - 2009-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of food wafers for multiple daily oral treatments in young rats. AN - 67300793; 19476719 AB - Many laboratory studies require oral administration of drugs. Dietary administration in food or water is useful, but is not always the best method. Orogastric gavage can be stressful. Here, we describe in detail a relatively stress-free technique that can be applied to multiple daily administrations using a palatable food item. This method was successfully used to administer water or methylphenidate 3 times daily to young pair-housed adolescent rats. JF - Journal of the American Association for Laboratory Animal Science : JAALAS AU - Ferguson, Sherry A AU - Boctor, Sherin Y AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA. Sherry.Ferguson@fda.hhs.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 292 EP - 295 VL - 48 IS - 3 SN - 1559-6109, 1559-6109 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Methylphenidate -- administration & dosage KW - Animal Feed KW - Drug Delivery Systems -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67300793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.atitle=Use+of+food+wafers+for+multiple+daily+oral+treatments+in+young+rats.&rft.au=Ferguson%2C+Sherry+A%3BBoctor%2C+Sherin+Y&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2009-05-01&rft.volume=48&rft.issue=3&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.issn=15596109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2009-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Physiol Behav. 1999 Dec 1-15;68(1-2):99-107 [10627068] Environ Mol Mutagen. 2010 Mar;51(2):138-45 [19658152] Contemp Top Lab Anim Sci. 2000 Jan;39(1):17-21 [11178310] Prog Neurobiol. 2001 Dec;65(5):427-51 [11689280] Neurotoxicol Teratol. 2002 Jan-Feb;24(1):37-45 [11836070] Environ Health Perspect. 2002 Jun;110 Suppl 3:415-22 [12060838] Dev Psychobiol. 1971;4(3):193-248 [4950118] Physiol Behav. 1999 Jun;66(4):559-65 [10386897] J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):109-15 [10418984] Toxicol Sci. 2004 Dec;82(2):577-89 [15456922] Contemp Top Lab Anim Sci. 2004 Nov;43(6):42-51 [15669134] Brain Res Bull. 2005 Apr 15;65(3):235-40 [15811586] Toxicol Sci. 2005 Oct;87(2):451-9 [16033993] Neurotoxicol Teratol. 2007 Mar-Apr;29(2):219-27 [17161936] Horm Behav. 2007 Sep;52(3):307-16 [17568585] Behav Neurosci. 2007 Dec;121(6):1272-9 [18085880] Brain Res Rev. 2008 Mar;57(2):571-85 [18164765] Toxicol Sci. 2000 Jun;55(2):311-9 [10828262] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicological evaluation of an apicidin derivative, histone deacetylase inhibitor SD-2007 in mice. AN - 67283500; 19471895 AB - SD-2007 is a new derivative of apicidin, an anti-parasitic agent and a histone deacetylase (HDAC) inhibitor. A subacute toxicological evaluation of SD-2007 was investigated for 2 weeks in ICR mice. After oral administration of SD-2007 (0, 0.2, 1, 5 or 25 mg/mouse), the clinical signs, mortalities, body weight changes, blood biochemical parameters, absolute and relative organ weights were examined. One day after the administration of SD-2007, excretion of soft feces in 1 and 5 mg/head groups, and one male in 25 mg/mouse group developed diarrhea, but theses complications were disappeared two days after administration. No mortalities were observed in animals up to 25 mg/mouse (LD(50), >25 mg/kg), but absolute and relative weights of testes were significantly lower at the highest dose group (25 mg/mouse) and serum LDH and glucose levels were elevated in male mice. In addition, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) activities were reduced in female mice at all dosages. These data suggest that SD- 2007 may be sex specific and be toxic to the male reproductive organ, and thus our findings require further investigation and in particular chronic toxicological investigations should be investigated. JF - Archives of pharmacal research AU - Kwack, Seung Jun AU - Kim, Kyu Bong AU - Lee, Byung Mu AD - Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, 122-704, Korea. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 789 EP - 797 VL - 32 IS - 5 SN - 0253-6269, 0253-6269 KW - Antiparasitic Agents KW - 0 KW - Biomarkers KW - Enzyme Inhibitors KW - Histone Deacetylase Inhibitors KW - Peptides, Cyclic KW - SD-2007 KW - Index Medicus KW - Administration, Oral KW - Animals KW - Mice, Inbred ICR KW - Sex Factors KW - Dose-Response Relationship, Drug KW - Mice KW - Body Weight -- drug effects KW - Lethal Dose 50 KW - Time Factors KW - Biomarkers -- blood KW - Female KW - Male KW - Organ Size -- drug effects KW - Peptides, Cyclic -- administration & dosage KW - Enzyme Inhibitors -- administration & dosage KW - Antiparasitic Agents -- administration & dosage KW - Enzyme Inhibitors -- toxicity KW - Peptides, Cyclic -- toxicity KW - Antiparasitic Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67283500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pharmacal+research&rft.atitle=Toxicological+evaluation+of+an+apicidin+derivative%2C+histone+deacetylase+inhibitor+SD-2007+in+mice.&rft.au=Kwack%2C+Seung+Jun%3BKim%2C+Kyu+Bong%3BLee%2C+Byung+Mu&rft.aulast=Kwack&rft.aufirst=Seung&rft.date=2009-05-01&rft.volume=32&rft.issue=5&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Archives+of+pharmacal+research&rft.issn=02536269&rft_id=info:doi/10.1007%2Fs12272-009-1519-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-29 N1 - Date created - 2009-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s12272-009-1519-0 ER - TY - JOUR T1 - CYP3A polymorphisms and immunosuppressive drugs in solid-organ transplantation. AN - 67226185; 19435458 AB - Most immunosuppressive drugs have a narrow therapeutic index and large interpatient variabilities in their pharmacokinetic and pharmacodynamic profiles. Identification of functional single-nucleotide polymorphisms in genes encoding for drug metabolizing enzymes has great potential to improve the drug efficacy and safety profiles, since these genetic factors may be important biomarkers for individualization of immunosuppressive therapy. This article summarizes current knowledge regarding the impact of CYP3A polymorphisms on immunosuppressive drug pharmacokinetics. Many retrospective studies have shown a clear relationship between CYP3A5*1/*3 polymorphism and tacrolimus pharmacokinetics, while the influence of CYP3A5*1/*3 or CYP3A4*/*1B on ciclosporin and sirolimus exposure are still questionable. CYP3A polymorphisms may partially contribute to the clinical variability of the enzyme-mediated drug interactions. Drug-drug interactions may also influence the phenotypic consequence of CYP3A polymorphisms. Population pharmacodynamic/kinetic/genomic modeling was proposed as an emerging and promising approach to quantitatively explore the contribution of genetic polymorphisms to the large interpatient variability in the pharmacokinetic and pharmacodynamic profiles of immunosuppressive drugs. Prospective, randomized studies in large patient populations are needed to further clarify the genetic effects of CYP3A on immunosuppressive drug exposure and response. JF - Expert review of molecular diagnostics AU - Wang, Jian AD - Office of Clinical Pharmacology, Center for Drug Research and Evaluation, The US FDA, Silver Spring, MD 20993, USA. jian.wang@fda.hhs.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 383 EP - 390 VL - 9 IS - 4 KW - Antifungal Agents KW - 0 KW - Immunosuppressive Agents KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - CYP3A protein, human KW - EC 1.14.14.1 KW - CYP3A5 protein, human KW - Cytochrome P-450 CYP3A KW - Tacrolimus KW - WM0HAQ4WNM KW - Index Medicus KW - Genetic Variation KW - Drug Interactions KW - Tacrolimus -- therapeutic use KW - Gene Frequency KW - Humans KW - Safety KW - Antifungal Agents -- therapeutic use KW - Polymorphism, Single Nucleotide KW - Polymorphism, Genetic KW - Cytochrome P-450 Enzyme System -- genetics KW - Organ Transplantation -- standards KW - Cytochrome P-450 CYP3A -- genetics KW - Immunosuppressive Agents -- therapeutic use KW - Immunosuppressive Agents -- pharmacokinetics KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67226185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+molecular+diagnostics&rft.atitle=CYP3A+polymorphisms+and+immunosuppressive+drugs+in+solid-organ+transplantation.&rft.au=Wang%2C+Jian&rft.aulast=Wang&rft.aufirst=Jian&rft.date=2009-05-01&rft.volume=9&rft.issue=4&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+molecular+diagnostics&rft.issn=1744-8352&rft_id=info:doi/10.1586%2Ferm.09.11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-16 N1 - Date created - 2009-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1586/erm.09.11 ER - TY - JOUR T1 - OECD validation of phase 3 Hershberger assay in Korea using surgically castrated male rats with coded chemicals. AN - 67222480; 19241440 AB - As a participating laboratory for the OECD Hershberger validation program, we conducted a phase 3 trial to test the reliability of the Hershberger assay using coded substances. Male Sprague-Dawley rats were castrated at 6 weeks of age and allowed to recover for 8 days. All the coded substances were administered orally once daily for 10 consecutive days. In the antagonist version of the assay, 0.4 mg kg(-1) of testosterone propionate (TP), a reference androgen, was co-administered with the coded compounds C, D, H, I or K, by a subcutaneous injection. As anticipated, TP alone produced statistically significant increases in the five mandatory accessory sex organ weights. The coded substance L (trenbolone 40 mg kg(-1)), the test agonist, caused significant increases in the weights of the androgen-dependent tissues. The five coded compounds, p,p'-DDE at two doses (codes C and I), linuron at two doses (codes D and K) and flutamide (code H), all significantly decreased the weights of the TP-stimulated sex organs. These results suggest the OECD Hershberger assay to be a reliable screening method for detecting androgen agonists and antagonists. JF - Journal of applied toxicology : JAT AU - Moon, Hyun-Ju AU - Kang, Tae Seok AU - Kim, Tae Sung AU - Kang, Il Hyun AU - Ki, Ho Youn AU - Kim, Seung Hee AU - Han, Soon Young AD - National Institute of Toxicological Research, Korea Food and Drug Administration, 194 Tongil-ro, Eunpyung-gu, Seoul 122-704, Korea. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 350 EP - 355 VL - 29 IS - 4 KW - Anabolic Agents KW - 0 KW - Androgen Antagonists KW - Androgens KW - Endocrine Disruptors KW - Insecticides KW - Linuron KW - 01XP1SU59O KW - Testosterone KW - 3XMK78S47O KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - Flutamide KW - 76W6J0943E KW - Trenbolone Acetate KW - RUD5Y4SV0S KW - Index Medicus KW - Trenbolone Acetate -- toxicity KW - Insecticides -- toxicity KW - Animals KW - Androgen Antagonists -- toxicity KW - Testosterone -- toxicity KW - Reproduction -- drug effects KW - Biological Assay KW - Androgens -- agonists KW - Korea KW - Pregnancy KW - Rats KW - Anabolic Agents -- toxicity KW - Rats, Sprague-Dawley KW - Linuron -- toxicity KW - Body Weight -- drug effects KW - Flutamide -- toxicity KW - Follow-Up Studies KW - Dichlorodiphenyl Dichloroethylene -- toxicity KW - Male KW - Female KW - Organ Size -- drug effects KW - Endocrine Disruptors -- toxicity KW - Orchiectomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67222480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=OECD+validation+of+phase+3+Hershberger+assay+in+Korea+using+surgically+castrated+male+rats+with+coded+chemicals.&rft.au=Moon%2C+Hyun-Ju%3BKang%2C+Tae+Seok%3BKim%2C+Tae+Sung%3BKang%2C+Il+Hyun%3BKi%2C+Ho+Youn%3BKim%2C+Seung+Hee%3BHan%2C+Soon+Young&rft.aulast=Moon&rft.aufirst=Hyun-Ju&rft.date=2009-05-01&rft.volume=29&rft.issue=4&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.1418 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jat.1418 ER - TY - JOUR T1 - State variations in the out-of-pocket spending burden for outpatient mental health treatment. AN - 67197389; 19414879 AB - We examine the potential of mental health/substance abuse (MH/SA) parity laws to reduce the out-of-pocket spending burden for outpatient treatment at the state level by exploring cross-state variations and their causes, as well as the provisions of MH/SA parity laws. We find modest (yet important) variation in out-of-pocket burden across states overall, but-because prescription medications account for two-thirds of out-of-pocket spending and are generally beyond the scope of recently enacted federal parity laws-evidence suggests that those laws will do little to reduce the observed burden or its variation. Other policy measures, designed to expand and improve health insurance coverage or reduce racial/ethnic disparities, could have a more profound impact. JF - Health affairs (Project Hope) AU - Zuvekas, Samuel H AU - Meyerhoefer, Chad D AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, in Rockville, Maryland, USA. samuel.zuvekas@ahrq.hhs.gov PY - 2009 SP - 713 EP - 722 VL - 28 IS - 3 KW - Index Medicus KW - United States KW - Health Services Needs and Demand -- economics KW - Drug Costs -- legislation & jurisprudence KW - Humans KW - Healthcare Disparities -- legislation & jurisprudence KW - Insurance, Pharmaceutical Services -- legislation & jurisprudence KW - Health Services Needs and Demand -- legislation & jurisprudence KW - Healthcare Disparities -- economics KW - Insurance, Pharmaceutical Services -- economics KW - Financing, Personal -- economics KW - Health Expenditures -- legislation & jurisprudence KW - Mental Disorders -- rehabilitation KW - Health Expenditures -- statistics & numerical data KW - Insurance Benefits -- economics KW - Substance-Related Disorders -- economics KW - Financing, Personal -- legislation & jurisprudence KW - Insurance, Psychiatric -- legislation & jurisprudence KW - Substance-Related Disorders -- rehabilitation KW - State Health Plans -- economics KW - Insurance Benefits -- legislation & jurisprudence KW - Ambulatory Care -- economics KW - State Health Plans -- legislation & jurisprudence KW - Ambulatory Care -- legislation & jurisprudence KW - Mental Disorders -- economics KW - Insurance, Psychiatric -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67197389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+affairs+%28Project+Hope%29&rft.atitle=State+variations+in+the+out-of-pocket+spending+burden+for+outpatient+mental+health+treatment.&rft.au=Zuvekas%2C+Samuel+H%3BMeyerhoefer%2C+Chad+D&rft.aulast=Zuvekas&rft.aufirst=Samuel&rft.date=2009-05-01&rft.volume=28&rft.issue=3&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Health+affairs+%28Project+Hope%29&rft.issn=1544-5208&rft_id=info:doi/10.1377%2Fhlthaff.28.3.713 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-03 N1 - Date created - 2009-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1377/hlthaff.28.3.713 ER - TY - JOUR T1 - The mouse lymphoma assay detects recombination, deletion, and aneuploidy. AN - 67193480; 19237551 AB - The mouse lymphoma assay (MLA) uses the thymidine kinase (Tk) gene of the L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cell line as a reporter gene to evaluate the mutagenicity of chemical and physical agents. The MLA is recommended by both the United States Food and Drug Administration and the United States Environmental Protection Agency as the preferred in vitro mammalian cell mutation assay for genetic toxicology screening because it detects a wide range of genetic alterations, including both point mutations and chromosomal mutations. However, the specific types of chromosomal mutations that can be detected by the MLA need further clarification. For this purpose, three chemicals, including two clastogens and an aneugen (3'-azido-3'-deoxythymidine, mitomycin C, and taxol), were used to induce Tk mutants. Loss of heterozygosity (LOH) analysis was used to select mutants that could be informative as to whether they resulted from deletion, mitotic recombination, or aneuploidy. A combination of additional methods, G-banding analysis, chromosome painting, and a real-time PCR method to detect the copy number (CN) of the Tk gene was then used to provide a detailed analysis. LOH involving at least 25% of chromosome 11, a normal karyotype, and a Tk CN of 2 would indicate that the mutant resulted from recombination, whereas LOH combined with a karyotypically visible deletion of chromosome 11 and a Tk CN of 1 would indicate a deletion. Aneuploidy was confirmed using G-banding combined with chromosome painting analysis for mutants showing LOH at every microsatellite marker on chromosome 11. From this analysis, it is clear that mouse lymphoma Tk mutants can result from recombination, deletion, and aneuploidy. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Wang, Jianyong AU - Sawyer, Jeffrey R AU - Chen, Ling AU - Chen, Tao AU - Honma, Masamitsu AU - Mei, Nan AU - Moore, Martha M AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research/ Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 96 EP - 105 VL - 109 IS - 1 KW - Antimetabolites KW - 0 KW - Antineoplastic Agents, Phytogenic KW - Mutagens KW - Nucleic Acid Synthesis Inhibitors KW - Zidovudine KW - 4B9XT59T7S KW - Mitomycin KW - 50SG953SK6 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Cytogenetic Analysis KW - Mitomycin -- toxicity KW - Cell Line, Tumor KW - Mice KW - Gene Dosage -- drug effects KW - Antimetabolites -- toxicity KW - Antineoplastic Agents, Phytogenic -- toxicity KW - Zidovudine -- toxicity KW - Paclitaxel -- toxicity KW - Nucleic Acid Synthesis Inhibitors -- toxicity KW - Metaphase -- drug effects KW - Chromosomes, Mammalian -- drug effects KW - Loss of Heterozygosity -- drug effects KW - Lymphoma KW - Mutagenicity Tests KW - Aneuploidy KW - Recombination, Genetic -- drug effects KW - Mutagens -- toxicity KW - Thymidine Kinase -- genetics KW - Gene Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67193480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=The+mouse+lymphoma+assay+detects+recombination%2C+deletion%2C+and+aneuploidy.&rft.au=Wang%2C+Jianyong%3BSawyer%2C+Jeffrey+R%3BChen%2C+Ling%3BChen%2C+Tao%3BHonma%2C+Masamitsu%3BMei%2C+Nan%3BMoore%2C+Martha+M&rft.aulast=Wang&rft.aufirst=Jianyong&rft.date=2009-05-01&rft.volume=109&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfp037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-24 N1 - Date created - 2009-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfp037 ER - TY - JOUR T1 - Asbestosis mortality in the USA: facts and predictions. AN - 67148280; 19017689 AB - Mortality trends in the USA show that deaths from asbestosis are increasing, while deaths related to other pneumoconiosis are declining. To analyse the association between asbestos consumption and asbestosis mortality trends. In an epidemiological time series study, we used a modern computer-intensive local regression method to evaluate the relationship between asbestos consumption per capita (1900-2006) as the predictor variable and number of deaths from asbestosis (1968-2004). The predictor variable was progressively lagged by annual increments from 30 to 60 years and the goodness of fit assessed for each lag period. The model having the smallest Akaike's Information Criteria was used to derive extrapolated estimates of future mortality based on more recent asbestos consumption data. Asbestos consumption per capita reached a peak in 1951 and gradually declined until 1973, when it started to drop rapidly. In 2006, it was 0.0075 kg/person/year. There were 25 564 deaths from asbestosis over the period 1968-2004. The best-fitting model (adjusted coefficient of determination (R(2)) = 99.7%) for 1968-2004 deaths from asbestosis used asbestos consumption per capita 48 years prior (1920-1956) and the log value of asbestos consumption per capita 43 years prior (1925-1961). This model predicts a total of 29 667 deaths (95% CI 19 629 to 39 705) to occur during 2005-2027 (an average of 1290 deaths per year). This study demonstrates a clear association between asbestos consumption and deaths from asbestosis and indicates that asbestosis deaths are not expected to decrease sharply in the next 10-15 years. JF - Occupational and environmental medicine AU - Antao, V C dos Santos AU - Pinheiro, G A AU - Wassell, J T AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. VAntao@cdc.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 335 EP - 338 VL - 66 IS - 5 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Young Adult KW - Aged, 80 and over KW - Pneumoconiosis -- mortality KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Forecasting KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Asbestosis -- mortality KW - Asbestos -- supply & distribution KW - Asbestos -- toxicity KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67148280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Asbestosis+mortality+in+the+USA%3A+facts+and+predictions.&rft.au=Antao%2C+V+C+dos+Santos%3BPinheiro%2C+G+A%3BWassell%2C+J+T&rft.aulast=Antao&rft.aufirst=V+C+dos&rft.date=2009-05-01&rft.volume=66&rft.issue=5&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foem.2008.039172 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-30 N1 - Date created - 2009-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/oem.2008.039172 ER - TY - JOUR T1 - Potential in vitro effects of carbon nanotubes on human aortic endothelial cells. AN - 67122871; 19268679 AB - Respiratory exposure of mice to carbon nanotubes induces pulmonary toxicity and adverse cardiovascular effects associated with atherosclerosis. We hypothesize that the direct contact of carbon nanotubes with endothelial cells will result in dose-dependent effects related to altered cell function and cytotoxicity which may play a role in potential adverse pulmonary and cardiovascular outcomes. To test this hypothesis, we examined the effects of purified single- and multi-walled carbon nanotubes (SWCNT and MWCNT) on human aortic endothelial cells by evaluating actin filament integrity and VE-cadherin distribution by fluorescence microscopy, membrane permeability by measuring the lactate dehydrogenase (LDH) release, proliferation/viability by WST-1 assay, and overall functionality by tubule formation assay. Marked actin filament and VE-cadherin disruption, cytotoxicity, and reduced tubule formation occurred consistently at 24 h post-exposure to the highest concentrations [50-150 microg/10(6) cells (1.5-4.5 microg/ml)] for both SWCNT and MWCNT tested in our studies. These effects were not observed with carbon black exposure and carbon nanotube exposure in lower concentrations [1-10 microg/10(6) cells (0.04-0.4 microg/ml)] or in any tested concentrations at 3 h post-exposure. Overall, the results indicate that SWCNT and MWCNT exposure induce direct effects on endothelial cells in a dose-dependent manner. JF - Toxicology and applied pharmacology AU - Walker, Valerie G AU - Li, Zheng AU - Hulderman, Tracy AU - Schwegler-Berry, Diane AU - Kashon, Michael L AU - Simeonova, Petia P AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Y1 - 2009/05/01/ PY - 2009 DA - 2009 May 01 SP - 319 EP - 328 VL - 236 IS - 3 KW - Antigens, CD KW - 0 KW - Cadherins KW - Interleukin-8 KW - Nanotubes, Carbon KW - cadherin 5 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Microscopy, Fluorescence KW - Microscopy, Electron, Transmission KW - Cadherins -- metabolism KW - Cells, Cultured KW - Humans KW - In Vitro Techniques KW - Antigens, CD -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Cell Membrane Permeability KW - Interleukin-8 -- metabolism KW - L-Lactate Dehydrogenase -- metabolism KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Aorta -- drug effects KW - Aorta -- enzymology KW - Aorta -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67122871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Potential+in+vitro+effects+of+carbon+nanotubes+on+human+aortic+endothelial+cells.&rft.au=Walker%2C+Valerie+G%3BLi%2C+Zheng%3BHulderman%2C+Tracy%3BSchwegler-Berry%2C+Diane%3BKashon%2C+Michael+L%3BSimeonova%2C+Petia+P&rft.aulast=Walker&rft.aufirst=Valerie&rft.date=2009-05-01&rft.volume=236&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2009.02.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-04 N1 - Date created - 2009-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2009.02.018 ER - TY - JOUR T1 - Bias from matching on age at death or censor in nested case-control studies. AN - 67118309; 19289956 AB - Nested case-control studies frequently use incidence-density sampling based on attained age when matching controls to cases. A recently suggested additional matching criterion is age at death, with eligible controls having an age at death or censor within a specified number of years of the case's age at death. We simulated occupational cohorts with time-dependent exposures to evaluate whether adding this criterion introduces bias, and we investigated alternative methods of treating workers with zero exposure because of latency assumptions (ie, "lagged-out"). We used simulated cohorts to consider null, positive, and negative exposure effects and lag periods of 0 and 10 years. Risk sets were constructed using incidence-density sampling with matching on attained age alone or attained age plus age at death. We estimated exposure effects using conditional logistic regression for unlagged and 10-year lagged cumulative exposure. Lagged-out workers were either excluded or included and assigned zero exposure. Effect estimates were generally unbiased when controls were selected by matching on attained age alone. However, the estimates were downwardly biased under the additional matching criterion. When risk was related to a lagged cumulative exposure, estimates including lagged-out workers were similarly or less biased than those excluding lagged-out workers. In these simulations, incidence-density sampling with matching on attained age plus age at death introduced bias. This is because sampled controls were younger at first exposure, with higher cumulative exposure compared with controls selected by matching on attained age alone. Incidence-density sampling with matching on attained age alone (and including lagged-out workers) did not introduce bias. JF - Epidemiology (Cambridge, Mass.) AU - Hein, Misty J AU - Deddens, James A AU - Schubauer-Berigan, Mary K AD - Division of Surveillance, National Institute for Occupational Safety and Health, Hazard Evaluations and Field Studies, Cincinnati, OH 45226, USA. MHein@cdc.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 330 EP - 338 VL - 20 IS - 3 KW - Index Medicus KW - Occupational Exposure KW - Logistic Models KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Epidemiologic Research Design KW - Mortality KW - Case-Control Studies KW - Bias (Epidemiology) KW - Age Distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67118309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Bias+from+matching+on+age+at+death+or+censor+in+nested+case-control+studies.&rft.au=Hein%2C+Misty+J%3BDeddens%2C+James+A%3BSchubauer-Berigan%2C+Mary+K&rft.aulast=Hein&rft.aufirst=Misty&rft.date=2009-05-01&rft.volume=20&rft.issue=3&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=1531-5487&rft_id=info:doi/10.1097%2FEDE.0b013e31819ed4d2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-03 N1 - Date created - 2009-04-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Epidemiology. 2009 May;20(3):339-40 [19289961] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/EDE.0b013e31819ed4d2 ER - TY - JOUR T1 - Substance use among women: associations with pregnancy, parenting, and race/ethnicity. AN - 67041291; 18566878 AB - To examine the association of pregnancy and parenting (0- to 2-year-old child) statuses with past 30-day use of alcohol, cigarettes and marijuana, psychotherapeutics and cocaine among American women aged 18-44, overall and by race/ethnicity. Five years of data (2002-2006) from the National Survey on Drug Use and Health (NSDUH) were pooled. Binary logistic regression analyses stratified by race/ethnicity were performed to examine the relationships adjusting for age, marital status, education and family income. Overall, past 30-day alcohol, cigarette, marijuana, psychotherapeutic or cocaine use was substantially lower among pregnant women, particularly in their second or third trimesters, than among their parenting or non-pregnant counterparts. Logistic regression analysis suggested a strong negative association between pregnancy status and substance use, with no considerable variations in the magnitude of the relationship by race/ethnicity for most measures. The relationship between parenting status and substance use was in the same direction, but relatively weak, and not statistically significant for non-Hispanic (NH) blacks for any measures except for alcohol use. Regardless of pregnancy and parenting statuses, NH white women reported substance use at the highest rates, followed by Hispanics and NH blacks. There is indirect evidence of postpregnancy resumption in substance use. Pregnant and parenting women, regardless of race/ethnicity, could benefit from prevention efforts focusing on cessation rather than temporary abstinence from substance use. JF - Maternal and child health journal AU - Muhuri, Pradip K AU - Gfroerer, Joseph C AD - Division of Population Surveys, Office of Applied Studies, Substance Abuse & Mental Health Services Administration, 1 Choke Cherry Road, Room # 7-1023, Rockville MD, 20857, USA. pradip.muhuri@samhsa.hhs.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 376 EP - 385 VL - 13 IS - 3 KW - Index Medicus KW - Young Adult KW - Cross-Sectional Studies KW - Humans KW - Adult KW - Adolescent KW - United States -- epidemiology KW - Psychotherapeutic Processes KW - Female KW - Pregnancy KW - Substance-Related Disorders -- ethnology KW - Parenting -- ethnology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67041291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maternal+and+child+health+journal&rft.atitle=Substance+use+among+women%3A+associations+with+pregnancy%2C+parenting%2C+and+race%2Fethnicity.&rft.au=Muhuri%2C+Pradip+K%3BGfroerer%2C+Joseph+C&rft.aulast=Muhuri&rft.aufirst=Pradip&rft.date=2009-05-01&rft.volume=13&rft.issue=3&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Maternal+and+child+health+journal&rft.issn=1573-6628&rft_id=info:doi/10.1007%2Fs10995-008-0375-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-10 N1 - Date created - 2009-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10995-008-0375-8 ER - TY - JOUR T1 - The Changing Role of the State Psychiatric Hospital AN - 58801174; 2008-329955 AB - State hospitals were once the most prominent components of U.S. public mental health systems. But a major focus of mental health policy over the past fifty years has been to close these facilities. These efforts led to a 95 percent reduction in the country's state hospital population. However, more than 200 state hospitals remain open, serving a declining but challenging patient population. Using national and state-level data, this paper discusses the contemporary public mental hospital, the forces shaping its use, the challenges it faces, and its possible future role in the larger mental health system. Adapted from the source document. JF - Health Affairs AU - Fisher, William H AU - Geller, Jeffrey L AU - Pandiani, John A AD - Center for Mental Health Services Research, University of Massachusetts Medical School, Worcester Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 676 EP - 684 PB - Project HOPE, Bethesda MD VL - 28 IS - 3 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Health conditions and policy - Medicine and health care KW - Health conditions and policy - Hospitals and other health care facilities KW - Government - State or regional government KW - State government KW - Mental health KW - Psychiatry KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58801174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=The+Changing+Role+of+the+State+Psychiatric+Hospital&rft.au=Fisher%2C+William+H%3BGeller%2C+Jeffrey+L%3BPandiani%2C+John+A&rft.aulast=Fisher&rft.aufirst=William&rft.date=2009-05-01&rft.volume=28&rft.issue=3&rft.spage=676&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.28.3.676 LA - English DB - PAIS Index N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mental health; Psychiatry; Hospitals; State government DO - http://dx.doi.org/10.1377/hlthaff.28.3.676 ER - TY - JOUR T1 - Personality profiles of cultures: Patterns of ethos AN - 57309456; 200919671 AB - Culture and the human mind are deeply interdependent, because they co-evolved. Personality traits were a preexisting feature of the primate mind and must have left an imprint on forms of culture. Trait taxonomies can structure ethnographies, by specifying institutions that reflect the operation of traits. Facets of ethos can be assessed by expert ratings or objective indicators. Ratings of ethos in Japan and the US were reliable and yielded plausible descriptions of culture. However, measures of ethos based on the analysis of stories were not meaningfully correlated with aggregate personality traits or national character stereotypes. Profiles of ethos may provide another axis that can be used with aggregate personality trait levels to predict behaviour and understand the operation of culture. Published in 2009 by John Wiley & Sons, Ltd. [Copyright John Wiley and Sons, Ltd.] JF - European Journal of Personality AU - McCrae, Robert R AD - Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, USA mccraej@grc.nia.nih.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 205 EP - 227 PB - John Wiley & Sons, Chichester UK VL - 23 IS - 3 SN - 0890-2070, 0890-2070 KW - Sons KW - Classification KW - Ethnography KW - Personality KW - Primates KW - Japan KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57309456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Personality&rft.atitle=Personality+profiles+of+cultures%3A+Patterns+of+ethos&rft.au=McCrae%2C+Robert+R&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2009-05-01&rft.volume=23&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Personality&rft.issn=08902070&rft_id=info:doi/10.1002%2Fper.712 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - EJPEEU N1 - SubjectsTermNotLitGenreText - Personality; Classification; Ethnography; Sons; Japan; Primates DO - http://dx.doi.org/10.1002/per.712 ER - TY - JOUR T1 - Early Collaboration for Adaptation: Addressing Depression in Low-Income New Mothers AN - 57305049; 200923433 AB - This paper describes the development and implementation of a collaborative research project between a community agency and university-based researcher. The goal of the project was to address depression in low-income new mothers who would not ordinarily have access to mental health services. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Pfefferle, Susan G AU - Cooper, Ben AU - Layton, Debbie AU - Rohrbach, Sharon AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University, St. Louis, 1 Brookings Dr., Box 1093, St. Louis, MO 63130 Tel: (314) 935-6376 spfefferle@gwbmail.wustl.edu Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 539 EP - 544 PB - John Hopkins University Press, Baltimore MD VL - 20 IS - 2 SN - 1049-2089, 1049-2089 KW - Collaboration, perinatal depression, nurses, home visitation KW - Goals KW - Mental health services KW - Depression KW - Community agencies KW - Mothers KW - Low income people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57305049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Early+Collaboration+for+Adaptation%3A+Addressing+Depression+in+Low-Income+New+Mothers&rft.au=Pfefferle%2C+Susan+G%3BCooper%2C+Ben%3BLayton%2C+Debbie%3BRohrbach%2C+Sharon&rft.aulast=Pfefferle&rft.aufirst=Susan&rft.date=2009-05-01&rft.volume=20&rft.issue=2&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Mothers; Depression; Low income people; Mental health services; Community agencies; Goals ER - TY - JOUR T1 - Associating Supplemental Case Management Activities With Ethnic Minority Children's Reduced Use of Psychiatric Emergency Services AN - 57300741; 200916994 AB - Studying children and adolescents receiving publicly financed outpatient treatment, the authors investigated whether receipt of supplemental case management was associated with reduced odds of ethnic minority children's and adolescent's receipt of crisis care, and whether the minority's reduction was greater than the reduction for Whites. The data were 97,618 Medicaid records of mental health services provided to children and adolescents ages 0 -18 years in California's public mental health system. The study's quasi-experimental research capitalized on a large, multisystem, and multiyear data set to address key challenges to internal and external validity. Results indicated that receiving case management along with outpatient treatment was associated with significantly reduced odds of crisis service use for Blacks, Asian Americans, and Latinos especially. The results provide preliminary evidence that supplementing outpatient care with case management helps to close a troubling disparity in mental health treatment access. [Copyright Elsevier B.V.] JF - Psychological Services AU - Snowden, Lonnie R AU - Masland, Mary C AU - Wallace, Neal AU - Fawley, Kya AD - Center for Mental Health Services Research, University of California, Berkeley snowden@berkeley.edu Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 117 EP - 125 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 6 IS - 2 SN - 1541-1559, 1541-1559 KW - race crisis emergency psychiatry children KW - Case management KW - Mental health services KW - Ethnic minorities KW - Children KW - Adolescents KW - Outpatient treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57300741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Associating+Supplemental+Case+Management+Activities+With+Ethnic+Minority+Children%27s+Reduced+Use+of+Psychiatric+Emergency+Services&rft.au=Snowden%2C+Lonnie+R%3BMasland%2C+Mary+C%3BWallace%2C+Neal%3BFawley%2C+Kya&rft.aulast=Snowden&rft.aufirst=Lonnie&rft.date=2009-05-01&rft.volume=6&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0015346 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Mental health services; Case management; Outpatient treatment; Ethnic minorities; Adolescents; Children DO - http://dx.doi.org/10.1037/a0015346 ER - TY - JOUR T1 - The Experiences of Involuntarily Childless Turkish Immigrants in the Netherlands AN - 57288762; 200913253 AB - The consequences of involuntary childlessness are influenced by culture in several ways. In this study we explored the experiences and responses of infertile Turkish immigrants in the Netherlands. Twenty in-depth interviews were conducted with involuntarily childless Turkish immigrants in the Netherlands (11 couples and 9 women). Interviews were transcribed verbatim and were analyzed using interpretative phenomenological analysis (IPA). The respondents' experiences were clustered around six superordinate themes: effects on self; effects on the relationship with the partner; effects on the relationship with others; disclosure; coping; and the future. Most transcripts revealed that involuntary childlessness has a profound negative influence on multiple aspects of the lives of the respondents. Strong pronatalist ideology, misconceptions about infertility and treatment, and migration-related aspects such as language difficulties, appear to play a role in the negative experiences of Turkish immigrants. Respondents reported several ways of coping (to some extent) with these negative experiences. [Reprinted by permission of Sage Publications Inc., copyright.] JF - Qualitative Health Research AU - van Rooij, Floor B AU - van Balen, Frank AU - Hermanns, Jo M A AD - Public Health Service of Amsterdam, Amsterdam, the Netherlands Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 621 EP - 632 PB - Sage Publications, Thousand Oaks CA VL - 19 IS - 5 SN - 1049-7323, 1049-7323 KW - coping and adaptation culture immigrants infertility interpretative phenomenological analysis (IPA) minorities reproduction stigma Turkey Turkish people KW - Childlessness KW - Immigrants KW - Negative experiences KW - Coping KW - Netherlands KW - Involuntary KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57288762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Health+Research&rft.atitle=The+Experiences+of+Involuntarily+Childless+Turkish+Immigrants+in+the+Netherlands&rft.au=van+Rooij%2C+Floor+B%3Bvan+Balen%2C+Frank%3BHermanns%2C+Jo+M+A&rft.aulast=van+Rooij&rft.aufirst=Floor&rft.date=2009-05-01&rft.volume=19&rft.issue=5&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Qualitative+Health+Research&rft.issn=10497323&rft_id=info:doi/10.1177%2F1049732309333242 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - QHREEM N1 - SubjectsTermNotLitGenreText - Immigrants; Netherlands; Coping; Negative experiences; Childlessness; Involuntary DO - http://dx.doi.org/10.1177/1049732309333242 ER - TY - JOUR T1 - Nursing-sensitive safety and quality outcomes: the taming of a wicked problem? AN - 57279653; 200911997 AB - There are tremendous opportunities associated with the increasing interest in outcomes that are sensitive to the effects of nursing. However, the challenges in realizing these opportunities are significant, and can be characterized as 'wicked'. Taming these challenges requires that we manage highly interdependent processes and techniques, including health information technologies. [Copyright Elsevier B.V.] JF - Applied Nursing Research AU - Harris, Marcelline AU - Vanderboom, Catherine AU - Hughes, Ronda AD - Mayo Clinic Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 146 EP - 151 PB - W.B. Saunders/Elsevier Ltd, The Netherlands VL - 22 IS - 2 SN - 0897-1897, 0897-1897 KW - Nursing KW - Safety KW - Information technology KW - Health information KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57279653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Nursing+Research&rft.atitle=Nursing-sensitive+safety+and+quality+outcomes%3A+the+taming+of+a+wicked+problem%3F&rft.au=Harris%2C+Marcelline%3BVanderboom%2C+Catherine%3BHughes%2C+Ronda&rft.aulast=Harris&rft.aufirst=Marcelline&rft.date=2009-05-01&rft.volume=22&rft.issue=2&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Applied+Nursing+Research&rft.issn=08971897&rft_id=info:doi/10.1016%2Fj.apnr.2009.02.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Safety; Information technology; Nursing; Health information DO - http://dx.doi.org/10.1016/j.apnr.2009.02.002 ER - TY - JOUR T1 - Development of a Human-Murine Chimeric Immunoglobulin M Antibody for Use in the Serological Detection of Human Flavivirus Antibodies AN - 21498025; 12492597 AB - Current diagnosis of human flaviviral infections relies heavily on serological techniques such as the immunoglobulin M (IgM) antibody capture enzyme-linked immunosorbent assay (MAC-ELISA). Broad application of this assay is hindered by a lack of standardized human positive-control sera that react with the wide variety of flaviviruses that can cause human disease, e.g., dengue virus (DENV), West Nile virus (WNV), yellow fever virus (YFV), Japanese encephalitis virus (JEV), and St. Louis encephalitis virus (SLEV). We have created a human-murine chimeric antibody combining the variable regions of the broadly flavivirus cross-reactive murine monoclonal antibody (MAb) 6B6C-1 and the constant region of human IgM to produce a standardized reagent capable of replacing human positive-control sera in a MAC-ELISA for the diagnosis of all human flaviviral infections. The human-murine chimeric IgM antibody secreted from plasmid-transformed Sp2/0-Ag14 cells had a level of serological activity identical to that of 6B6C-1 as measured by ELISA, immunoblotting, and MAC-ELISA for multiple members of the flavivirus genus, including WNV, SLEV, YFV, DENV, and JEV. JF - Clinical and Vaccine Immunology AU - Thibodeaux, Brett A AU - Roehrig, John T AD - Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 3150 Rampart Road, Fort Collins, Colorado 80521, epx1@cdc.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 679 EP - 685 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 16 IS - 5 SN - 1556-6811, 1556-6811 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts; Immunology Abstracts KW - Dengue virus KW - Immunoblotting KW - Enzyme-linked immunosorbent assay KW - Human diseases KW - Monoclonal antibodies KW - Immunology KW - Disease control KW - Man-induced effects KW - Infection KW - Flavivirus KW - Encephalitis KW - Public health KW - Yellow fever virus KW - Antibodies KW - Constant region KW - ELISA KW - Japanese encephalitis virus KW - Vaccines KW - West Nile virus KW - Immunoglobulin M KW - Variable region KW - F 06905:Vaccines KW - V 22300:Methods KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21498025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Development+of+a+Human-Murine+Chimeric+Immunoglobulin+M+Antibody+for+Use+in+the+Serological+Detection+of+Human+Flavivirus+Antibodies&rft.au=Thibodeaux%2C+Brett+A%3BRoehrig%2C+John+T&rft.aulast=Thibodeaux&rft.aufirst=Brett&rft.date=2009-05-01&rft.volume=16&rft.issue=5&rft.spage=679&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00354-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Human diseases; Antibodies; Monoclonal antibodies; Immunology; Disease control; Man-induced effects; ELISA; Vaccines; Public health; Immunoblotting; Enzyme-linked immunosorbent assay; Constant region; Infection; Encephalitis; Immunoglobulin M; Variable region; Dengue virus; Yellow fever virus; Japanese encephalitis virus; West Nile virus; Flavivirus DO - http://dx.doi.org/10.1128/CVI.00354-08 ER - TY - JOUR T1 - T Cells from Lungs and Livers of Francisella tularensis-Immune Mice Control the Growth of Intracellular Bacteria AN - 21498016; 12511194 AB - Parenteral and respiratory vaccinations with the intracellular bacterium Francisella tularensis have been studied using the live vaccine strain (LVS) in a mouse model, and spleen cells from immune mice are often used for immunological studies. However, mechanisms of host immunological responses may be different in nonlymphoid organs that are important sites of infection, such as lung and liver. Using parenteral (intradermal) or respiratory (cloud aerosol) vaccination, here we examine the functions of resulting LVS-immune liver or lung cells, respectively. Surprisingly, LVS was considerably more virulent when administered by cloud aerosol than by intranasal instillation, suggesting method-dependent differences in initial localization and/or dissemination patterns. Only low doses were sublethal, and resolution of sublethal cloud aerosol infection was dependent on gamma interferon (IFN-), tumor necrosis factor alpha, and inducible nitric oxide synthase. Nonetheless, survival of cloud aerosol or parenteral infection resulted in the development of a protective immune response against lethal LVS intraperitoneal or aerosol challenge, reflecting development of systemic secondary immunity in both cases. Such immunity was further detected by directly examining the functions of LVS-immune lung or liver lymphocytes in vitro. Lung lymphocytes primed by respiratory infection, as well as liver lymphocytes primed by parenteral infection, clearly controlled in vitro intracellular bacterial growth primarily via mechanisms that were not dependent on IFN- activity. Thus, our results indicate functional similarities between immune T cells residing in spleens, livers, and lungs of LVS-immune mice. JF - Infection and Immunity AU - Collazo, Carmen M AU - Meierovics, Anda I AU - Pascalis, Roberto De AU - Wu, Terry H AU - Lyons, CRick AU - Elkins, Karen L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 20852, karen.elkins@fda.hhs.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 2010 EP - 2021 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 5 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Aerosols KW - g-Interferon KW - Hepatocytes KW - Animal models KW - Spleen KW - Francisella tularensis KW - Immunity KW - Tumor necrosis factor-a KW - Infection KW - Vaccination KW - Clouds KW - Nitric-oxide synthase KW - Interferon KW - Lung KW - Lymphocytes T KW - Liver KW - Vaccines KW - Immune response KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21498016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=T+Cells+from+Lungs+and+Livers+of+Francisella+tularensis-Immune+Mice+Control+the+Growth+of+Intracellular+Bacteria&rft.au=Collazo%2C+Carmen+M%3BMeierovics%2C+Anda+I%3BPascalis%2C+Roberto+De%3BWu%2C+Terry+H%3BLyons%2C+CRick%3BElkins%2C+Karen+L&rft.aulast=Collazo&rft.aufirst=Carmen&rft.date=2009-05-01&rft.volume=77&rft.issue=5&rft.spage=2010&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01322-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Aerosols; g-Interferon; Hepatocytes; Animal models; Spleen; Immunity; Infection; Tumor necrosis factor-a; Vaccination; Nitric-oxide synthase; Clouds; Interferon; Lung; Liver; Lymphocytes T; Immune response; Vaccines; Francisella tularensis DO - http://dx.doi.org/10.1128/IAI.01322-08 ER - TY - JOUR T1 - Evaluation of different RT enzyme standards for quantitation of retroviruses using the single-tube fluorescent product-enhanced reverse transcriptase assay AN - 21159603; 9206808 AB - PCR-based reverse transcriptase (RT) assays are highly sensitive for broad detection of retroviruses. These assays are currently used for demonstrating the absence of retroviral contamination in vaccines and can also be applied to clinical and laboratory research to investigate low-virus replication. A single-tube fluorescent product-enhanced reverse transcriptase assay (STF-PERT) has been published that was highly sensitive for retrovirus detection (<10 virions), with enhanced reproducibility and increased efficiency [Sears, J.F., Khan, A.S., 2003. Single-tube fluorescent product-enhanced reverse transcriptase assay with AmpliWax (STF-PERT) for retrovirus quantitation. J. Virol. Meth. 108, 139-142]. In this report, the step-by-step setup and performance of the STF-PERT assay is described and sensitivity, reproducibility and specificity of the assay reported using three different RTs as standards: avian myeloblastosis virus (AMV) RT, murine leukemia virus (MMLV) RT, and human immunodeficiency virus type 1 (HIV-1) RT. Evaluation of virus stocks showed about 1-2 logs difference in RT detection and retrovirus quantitation with the different RT enzyme standards; in general, virus determination using HIV-1 RT was comparable to using the relevant virus RT. JF - Journal of Virological Methods AU - Ma, Y K AU - Khan, A S AD - Division of Viral Products, Center for Biologics, Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, United States, arifa.khan@fda.hhs.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 133 EP - 140 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 157 IS - 2 SN - 0166-0934, 0166-0934 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Virions KW - Contamination KW - Replication KW - Enzymes KW - Avian myeloblastosis KW - Murine leukemia virus KW - Avian myeloblastosis virus KW - Retrovirus KW - Human immunodeficiency virus 1 KW - RNA-directed DNA polymerase KW - Vaccines KW - Quantitation KW - V 22360:AIDS and HIV KW - A 01390:Forestry KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21159603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Evaluation+of+different+RT+enzyme+standards+for+quantitation+of+retroviruses+using+the+single-tube+fluorescent+product-enhanced+reverse+transcriptase+assay&rft.au=Ma%2C+Y+K%3BKhan%2C+A+S&rft.aulast=Ma&rft.aufirst=Y&rft.date=2009-05-01&rft.volume=157&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2009.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Virions; Retrovirus; Contamination; Replication; Enzymes; RNA-directed DNA polymerase; Avian myeloblastosis; Vaccines; Quantitation; Human immunodeficiency virus 1; Murine leukemia virus; Avian myeloblastosis virus DO - http://dx.doi.org/10.1016/j.jviromet.2009.01.002 ER - TY - JOUR T1 - Prevalence of ROPS-equipped tractors on minority operated farms in the US AN - 20768329; 10246805 AB - Background Tractor overturns kill an average of 100 farmers and farm workers per year. Roll-over protective structures (ROPS) are a proven intervention, but are not on a sufficient number of tractors in the US to reduce these deaths. Little has been reported on ROPS use by racial minority farm operators. Methods Data from the NIOSH OISPA survey were used to assess ROPS prevalence rates from a random sample of racial minority farm operators for the year 2003, and ROPS prevalence rates from a random sample of all US farms for the year 2004. Results ROPS prevalence rates on minority farming operations follow similar patterns to ROPS prevalence rates on all US farms. A low prevalence of ROPS on farms was associated with operators over the age of 65 years, farms with small acreages, and farms operated on a part-time basis. The race of the operator had little impact on ROPS prevalence rates. Conclusions Factors such as acreage, farm operator age, region of the US, and full- or part-time farming status influence ROPS prevalence rates on farms more than the race of the operator. Understanding how ROPS prevalence differs across these farm and farm operator characteristics has the potential to efficiently target areas for ROPS promotion programs across the US. Am. J. Ind. Med. 52:408-418, 2009. JF - American Journal of Industrial Medicine AU - Myers, John R AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia, jrmyers@cdc.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 408 EP - 418 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 52 IS - 5 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - Age KW - farms KW - intervention KW - Ethnic groups KW - Agricultural equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20768329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Prevalence+of+ROPS-equipped+tractors+on+minority+operated+farms+in+the+US&rft.au=Myers%2C+John+R&rft.aulast=Myers&rft.aufirst=John&rft.date=2009-05-01&rft.volume=52&rft.issue=5&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20685 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Age; intervention; farms; Ethnic groups; Agricultural equipment; USA DO - http://dx.doi.org/10.1002/ajim.20685 ER - TY - CONF T1 - SEM-EDX analysis of an unknown "known" white powder found in a shipping container from Peru AN - 20753744; 10149604 AB - In 2008, an unknown white powder was discovered spilled inside of a shipping container of whole kernel corn during an inspection by federal inspectors in the port of Baltimore, Maryland. The container was detained and quarantined while a sample of the powder was collected and sent to a federal laboratory where it was screened using chromatography for the presence of specific poisons and pesticides with negative results. Samples of the corn kernels and the white powder were forwarded to the Food and Drug Administration, Forensic Chemistry Center for further analysis. Stereoscopic Light Microscopy (SLM), Scanning Electron Microscopy/Energy Dispersive X-ray Spectrometry (SEM/EDX), and Polarized Light Microscopy/Infrared Spectroscopy (PLM-IR) were used in the analysis of the kernels and the unknown powder. Based on the unique particle analysis by SLM and SEM as well as the detection of the presence of aluminum and phosphorous by EDX, the unknown was determined to be consistent with reacted aluminum phosphide (AlP). While commonly known in the agricultural industry, aluminum phosphide is relatively unknown in the forensic community. A history of the use and acute toxicity of this compound along with some very unique SEM/EDX analysis characteristics of aluminum phosphide will be discussed. JF - Proceedings of SPIE - The International Society for Optical Engineering AU - Albright, Douglas C Y1 - 2009/05// PY - 2009 DA - May 2009 PB - SPIE, P.O. BOX 10 Bellingham WA 98227-0010 USA, [mailto:spie@spie.org], [URL:http://spie.org] VL - 7378 KW - Environment Abstracts; Environmental Engineering Abstracts KW - Article no. 73782H KW - Containers KW - light microscopy KW - USA, Maryland, Baltimore, Port of Baltimore KW - forensic science KW - inspection KW - corn KW - Peru KW - Toxicity KW - Spectrometry KW - Microscopy KW - Aluminum KW - ENA 06:Food & Drugs KW - EE 10:General Environmental Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20753744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+SPIE+-+The+International+Society+for+Optical+Engineering&rft.atitle=SEM-EDX+analysis+of+an+unknown+%22known%22+white+powder+found+in+a+shipping+container+from+Peru&rft.au=Albright%2C+Douglas+C&rft.aulast=Albright&rft.aufirst=Douglas&rft.date=2009-05-01&rft.volume=7378&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+SPIE+-+The+International+Society+for+Optical+Engineering&rft.issn=0277786X&rft_id=info:doi/10.1117%2F12.827278 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - SuppNotes - Session: Applications of Scanning Microscopy to Forensics Science II N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1117/12.827278 ER - TY - JOUR T1 - Analysis of polonium-210 in food products and bioassay samples by isotope-dilution alpha spectrometry AN - 20751645; 9430737 AB - A rapid and reliable radiochemical method coupled with a simple and compact plating apparatus was developed, validated, and applied for the analysis of [super]210Po in variety of food products and bioassay samples. The method performance characteristics, including accuracy, precision, robustness, and specificity, were evaluated along with a detailed measurement uncertainty analysis. With high Po recovery, improved energy resolution, and effective removal of interfering elements by chromatographic extraction, the overall method accuracy was determined to be better than 5% with measurement precision of 10%, at 95% confidence level. JF - Applied Radiation and Isotopes AU - Lin, Zhichao AU - Wu, Zhongyu AD - Winchester Engineering and Analytical Center, Food and Drug Administration, 109 Holton Street, Winchester, MA 01890, USA, zhichao.lin@fda.hhs.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 907 EP - 912 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 67 IS - 5 SN - 0969-8043, 0969-8043 KW - Environment Abstracts KW - Polonium-210 KW - Food product KW - Alpha spectrometry KW - Bioassay KW - Plating apparatus KW - Radiochemical purification. KW - Isotopes KW - Bioassays KW - Spectrometry KW - ENA 14:Radiological Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20751645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Radiation+and+Isotopes&rft.atitle=Analysis+of+polonium-210+in+food+products+and+bioassay+samples+by+isotope-dilution+alpha+spectrometry&rft.au=Lin%2C+Zhichao%3BWu%2C+Zhongyu&rft.aulast=Lin&rft.aufirst=Zhichao&rft.date=2009-05-01&rft.volume=67&rft.issue=5&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Applied+Radiation+and+Isotopes&rft.issn=09698043&rft_id=info:doi/10.1016%2Fj.apradiso.2009.01.055 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Isotopes; Bioassays; Spectrometry DO - http://dx.doi.org/10.1016/j.apradiso.2009.01.055 ER - TY - JOUR T1 - A novel physiologic sampling pump capable of rapid response to breathing AN - 20688831; 10059804 AB - The merits of using physiologic sampling pumps (PSPs) instead of using constant-flow sampling pumps, i.e., "traditional sampling pumps" (TSPs), are discussed. A novel PSP that overcomes shortcomings of previous PSP designs is presented. Calibrated valves are used to obviate pump inertia that has limited the system response and accuracy of prior work. Technologies that provide minute ventilation (V sub(E)) of subjects in real time may therefore be used to the limit of their own accuracies to sample inhalation exposures. Analysis of the design and data from a prototype are presented to show how air sampling can be modulated to follow breathing. JF - Journal of Environmental Monitoring AU - Lee, L AU - Flemmer, M AU - Lee, E G AU - Harper, M AU - Lin, M-I AU - Groves, W AU - Freivalds, A AU - Slaven, J AD - National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division (HELD), Morgantown, WV, 26505-2888, USA Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 1020 EP - 1027 VL - 11 IS - 5 SN - 1464-0325, 1464-0325 KW - ASFA Marine Biotechnology Abstracts; Pollution Abstracts; Environment Abstracts KW - Environmental monitoring KW - Inhalation KW - Data processing KW - Ventilation KW - prototypes KW - Respiration KW - Air sampling KW - Pumps KW - Sampling KW - Technology KW - P 0000:AIR POLLUTION KW - Q4 27750:Environmental KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20688831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=A+novel+physiologic+sampling+pump+capable+of+rapid+response+to+breathing&rft.au=Lee%2C+L%3BFlemmer%2C+M%3BLee%2C+E+G%3BHarper%2C+M%3BLin%2C+M-I%3BGroves%2C+W%3BFreivalds%2C+A%3BSlaven%2C+J&rft.aulast=Lee&rft.aufirst=L&rft.date=2009-05-01&rft.volume=11&rft.issue=5&rft.spage=1020&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb816699d LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Inhalation; Environmental monitoring; Data processing; Ventilation; Respiration; Sampling; prototypes; Air sampling; Pumps; Technology DO - http://dx.doi.org/10.1039/b816699d ER - TY - JOUR T1 - Two Commonly Used Methods for Exposure- Adverse Events Analysis: Comparisons and Evaluations AN - 20667731; 9416659 AB - The purpose of this study is to compare and evaluate logistic regression and time-to-event analysis, 2 commonly used methods for exposure-adverse event (AE) analyses. An AE data set selected from clinical trials is analyzed by both methods and the results are compared. The parameter estimates, odds ratios for logistic regression, and hazard ratios for time-to-event analysis for each AE are compared and further analyzed. In a data set involving 822 patients, 25 AEs are analyzed. A linear relationship is demonstrated between the parameter estimates from the 2 methods and between the odds ratios and hazard ratios. The small differences between the 2 analyses are related to the lower rate of the events and the weaker effects of the risk factors. Although the 2 methods can make predications for the risks, the severity, duration, and recurrence are not well defined. AE time profiles showing the onset, duration, and offset of AEs are important for risk assessment and management. Both analyses can provide information about exposure-AE relationship, and the results from the 2 analyses are consistent in most cases. One should not use the logistic model when length of follow-up varies because of biased estimates. The application of the 2 methods should be combined with AE profiling. JF - Journal of Clinical Pharmacology AU - Duan, John Z AD - Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA, john.duan@fda.hhs.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 540 EP - 552 PB - Sage Publications Ltd., 6 Bonhill St. VL - 49 IS - 5 SN - 0091-2700, 0091-2700 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Data processing KW - Risk factors KW - clinical trials KW - Clinical trials KW - Side effects KW - Models KW - X 24310:Pharmaceuticals KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20667731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Two+Commonly+Used+Methods+for+Exposure-+Adverse+Events+Analysis%3A+Comparisons+and+Evaluations&rft.au=Duan%2C+John+Z&rft.aulast=Duan&rft.aufirst=John&rft.date=2009-05-01&rft.volume=49&rft.issue=5&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270009333485 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Risk assessment; Data processing; Risk factors; Clinical trials; Models; clinical trials; Side effects DO - http://dx.doi.org/10.1177/0091270009333485 ER - TY - JOUR T1 - DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide AN - 20626838; 9356353 AB - Acrylamide, a food contaminant, is carcinogenic in experimental animals, with both genotoxic and nongenotoxic pathways being proposed. To obtain information regarding mechanisms of acrylamide tumorigenesis, we compared the extent of DNA adduct formation and induction of micronuclei and mutations in mice treated neonatally with acrylamide and its electrophilic metabolite glycidamide. Male and female B6C3F1/Tk mice were treated intraperitoneally on postnatal days (PNDs) 1, 8 and 15 or PNDs 1-8 with 0.14 or 0.70 mmol acrylamide or glycidamide per kg body weight per day. One day after the final dose, B6C3F1/Tk+/+ mice were killed to measure DNA adduct levels and peripheral blood micronuclei. Three weeks after the last treatment, B6C3F1/Tk+/- mice were killed to assess the Hprt and Tk mutant frequencies in spleen lymphocytes. The levels of N7-(2-carbamoyl-2-hydroxyethyl)guanine, the major glycidamide-DNA adduct, decreased in the order 0.70 mmol glycidamide > 0.70 mmol acrylamide > 0.14 mmol glycidamide 0.14 mmol acrylamide. Only glycidamide increased the frequency of micronucleated reticulocytes and normochromatic erythrocytes. In mice treated on PNDs 1, 8 and 15, the Hprt mutant frequency was increased by 0.70 mmol glycidamide. In mice dosed on PNDs 1-,0.70 mmol glycidamide caused extensive mortality; each of the other treatments increased the Tk mutant frequency, whereas acrylamide increased the Hprt mutant frequency. These data suggest that the mutagenic response in neonatal mice treated on PNDs 1, 8 and 15 is due to glycidamide, whereas mutations resulting from dosing on PNDs 1-8 are due to another mechanism. JF - International Journal of Cancer AU - Von Tungeln, Linda S AU - Churchwell, Mona I AU - Doerge, Daniel R AU - Shaddock, Joseph G AU - McGarrity, Lynda J AU - Heflich, Robert H AU - da Costa, Goncalo Gamboa AU - Marques, M Matilde AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, frederick.beland@fda.hhs.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 2006 EP - 2015 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 9 SN - 0020-7136, 0020-7136 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Mortality KW - DNA adducts KW - Data processing KW - Erythrocytes KW - Micronuclei KW - Tumorigenesis KW - Genotoxicity KW - Spleen KW - Metabolites KW - Peripheral blood KW - Mutant frequency KW - Lymphocytes KW - Food contamination KW - Acrylamide KW - Body weight KW - Protein-tyrosine kinase KW - Neonates KW - Reticulocytes KW - Mutation KW - N 14820:DNA Metabolism & Structure KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20626838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=DNA+adduct+formation+and+induction+of+micronuclei+and+mutations+in+B6C3F1%2FTk+mice+treated+neonatally+with+acrylamide+or+glycidamide&rft.au=Von+Tungeln%2C+Linda+S%3BChurchwell%2C+Mona+I%3BDoerge%2C+Daniel+R%3BShaddock%2C+Joseph+G%3BMcGarrity%2C+Lynda+J%3BHeflich%2C+Robert+H%3Bda+Costa%2C+Goncalo+Gamboa%3BMarques%2C+M+Matilde%3BBeland%2C+Frederick+A&rft.aulast=Von+Tungeln&rft.aufirst=Linda&rft.date=2009-05-01&rft.volume=124&rft.issue=9&rft.spage=2006&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24165 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - DNA adducts; Mortality; Data processing; Genotoxicity; Tumorigenesis; Micronuclei; Erythrocytes; Spleen; Mutant frequency; Peripheral blood; Metabolites; Lymphocytes; Food contamination; Acrylamide; Body weight; Protein-tyrosine kinase; Neonates; Mutation; Reticulocytes DO - http://dx.doi.org/10.1002/ijc.24165 ER - TY - JOUR T1 - Characterization of an alternatively spliced GADD45 alpha , GADD45 alpha 1 isoform, in arsenic-treated epithelial cells AN - 20589228; 9306852 AB - A new GADD45 isoform, GADD451, was identified in the cellular response to arsenic. DNA sequencing and biochemical analyses suggested that GADD451 is derived from an alternative splicing of the GADD45 mRNA by skipping the region corresponding to exon2 of the gadd45 gene during mRNA maturation. In addition to the size difference due to the lack of 34 amino acids encoded by exon2, GADD451 and GADD45 proteins differ in their effects on cell proliferation and cell cycle transition. Unlike GADD45, the GADD451 is unable to attenuate cell growth. In over-expression experiments, the full length GADD45, but not the GADD451, sensitized cells to arsenic-induced prometaphase arrest of the cell cycle. Furthermore, GADD451 appears to be able to antagonize the function of the GADD45 on the G2/M phase cell cycle arrest as demonstrated in cotransfection experiment. Thus, these data suggest that the generation of the GADD451 isoform may not only offset but also antagonize the effects of arsenic and GADD45 on cell growth and cell cycle regulation. JF - Molecular Carcinogenesis AU - Zhang, Yadong AU - Beezhold, Kevin AU - Castranova, Vince AU - Shi, Xianglin AU - Chen, Fei AD - The Laboratory of Cancer Signaling and Epigenetics, The Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 454 EP - 464 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 5 SN - 0899-1987, 0899-1987 KW - Toxicology Abstracts KW - Epithelial cells KW - Gadd45A protein KW - Arsenic KW - Data processing KW - GADD45 protein KW - Cell cycle KW - Biochemical analysis KW - Alternative splicing KW - mRNA KW - DNA sequencing KW - Overexpression KW - Carcinogenesis KW - Cell proliferation KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20589228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Carcinogenesis&rft.atitle=Characterization+of+an+alternatively+spliced+GADD45+alpha+%2C+GADD45+alpha+1+isoform%2C+in+arsenic-treated+epithelial+cells&rft.au=Zhang%2C+Yadong%3BBeezhold%2C+Kevin%3BCastranova%2C+Vince%3BShi%2C+Xianglin%3BChen%2C+Fei&rft.aulast=Zhang&rft.aufirst=Yadong&rft.date=2009-05-01&rft.volume=48&rft.issue=5&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=Molecular+Carcinogenesis&rft.issn=08991987&rft_id=info:doi/10.1002%2Fmc.20483 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - GADD45 protein; Cell cycle; mRNA; Alternative splicing; Arsenic; Biochemical analysis; Data processing; Carcinogenesis; Overexpression; DNA sequencing; Gadd45A protein; Cell proliferation; Epithelial cells DO - http://dx.doi.org/10.1002/mc.20483 ER - TY - JOUR T1 - P12: Benchmark dose for 3-monochloro-propane-1,2-diol (3-MCPD) in rat 2-year study AN - 20564844; 9273456 AB - Abstract not available. JF - Experimental and Toxicologic Pathology AU - Hwang, Myungsil AU - Yun, Eukyung AU - Shin, Jae-Ho AU - Choi, Hong Serck AU - Kim, Ja Young AU - Jang, Dong Deuk AU - Yoo, Tae Moo AD - Risk Assessment Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul 122-704, Republic of Korea Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 287 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 61 IS - 3 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts KW - Toxicology KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20564844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=P12%3A+Benchmark+dose+for+3-monochloro-propane-1%2C2-diol+%283-MCPD%29+in+rat+2-year+study&rft.au=Hwang%2C+Myungsil%3BYun%2C+Eukyung%3BShin%2C+Jae-Ho%3BChoi%2C+Hong+Serck%3BKim%2C+Ja+Young%3BJang%2C+Dong+Deuk%3BYoo%2C+Tae+Moo&rft.aulast=Hwang&rft.aufirst=Myungsil&rft.date=2009-05-01&rft.volume=61&rft.issue=3&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2009.02.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Toxicology DO - http://dx.doi.org/10.1016/j.etp.2009.02.049 ER - TY - JOUR T1 - P05: Carcinogenicity study of 3-Monochloropropane-1,2-diol in Sprague-Dawley rats AN - 20564500; 9273449 AB - Abstract not available. JF - Experimental and Toxicologic Pathology AU - Han, Beom Seok AU - Cho, Wan-Seob AU - Lee, Hakyoung AU - Nam, Ki Taek AU - Park, Ki Dae AU - Choi, Mina AU - Kim, Seung Hee AU - Jeong, Jayoung AU - Jang, Dong Deuk AD - Department of Toxicological Research, Korea Food and Drug Administration, National Institute of Toxicological Research, Seoul 122-704, Republic of Korea Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 283 EP - 284 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 61 IS - 3 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts KW - Carcinogenicity KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20564500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=P05%3A+Carcinogenicity+study+of+3-Monochloropropane-1%2C2-diol+in+Sprague-Dawley+rats&rft.au=Han%2C+Beom+Seok%3BCho%2C+Wan-Seob%3BLee%2C+Hakyoung%3BNam%2C+Ki+Taek%3BPark%2C+Ki+Dae%3BChoi%2C+Mina%3BKim%2C+Seung+Hee%3BJeong%2C+Jayoung%3BJang%2C+Dong+Deuk&rft.aulast=Han&rft.aufirst=Beom&rft.date=2009-05-01&rft.volume=61&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2009.02.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Carcinogenicity DO - http://dx.doi.org/10.1016/j.etp.2009.02.042 ER - TY - JOUR T1 - S14: Use of transgenic mice in carcinogenicity hazard assessment: Is this the future? AN - 20560428; 9273422 AB - Abstract not available. JF - Experimental and Toxicologic Pathology AU - Jacobson-Kram, David AD - Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 262 EP - 263 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 61 IS - 3 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Carcinogenicity KW - Transgenic mice KW - W 30925:Genetic Engineering KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20560428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=S14%3A+Use+of+transgenic+mice+in+carcinogenicity+hazard+assessment%3A+Is+this+the+future%3F&rft.au=Jacobson-Kram%2C+David&rft.aulast=Jacobson-Kram&rft.aufirst=David&rft.date=2009-05-01&rft.volume=61&rft.issue=3&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2009.02.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Carcinogenicity; Transgenic mice DO - http://dx.doi.org/10.1016/j.etp.2009.02.015 ER - TY - JOUR T1 - Simplified lentivirus vector production in protein-free media using polyethylenimine-mediated transfection AN - 20518505; 9206793 AB - During the past 12 years, lentiviral vectors have emerged as valuable tools for transgene delivery because of their ability to transduce nondividing cells and their capacity to sustain long-term transgene expression. Despite significant progress, the production of high-titer high-quality lentiviral vectors is cumbersome and costly. The most commonly used method to produce lentiviral vectors involves transient transfection using calcium phosphate (CaP)-mediated precipitation of plasmid DNAs. However, inconsistencies in pH can cause significant batch-to-batch variations in lentiviral vector titers, making this method unreliable. This study describes optimized protocols for lentiviral vector production based on polyethylenimine (PEI)-mediated transfection, resulting in more consistent lentiviral vector stocks. To achieve this goal, simple production methods for high-titer lentiviral vector production involving transfection of HEK 293T cells immediately after plating were developed. Importantly, high titers were obtained with cell culture media lacking serum or other protein additives altogether. As a consequence, large-scale lentiviral vector stocks can now be generated with fewer batch-to-batch variations and at reduced costs and with less labor compared to the standard protocols. JF - Journal of Virological Methods AU - Kuroda, H AU - Kutner, R H AU - Bazan, NG AU - Reiser, J AD - Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA, Jakob.Reiser@fda.hhs.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 113 EP - 121 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 157 IS - 2 SN - 0166-0934, 0166-0934 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Expression vectors KW - Lentivirus KW - Transfection KW - Cell culture KW - Precipitation KW - Plasmids KW - pH effects KW - Media (culture) KW - Calcium phosphate KW - V 22300:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20518505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Simplified+lentivirus+vector+production+in+protein-free+media+using+polyethylenimine-mediated+transfection&rft.au=Kuroda%2C+H%3BKutner%2C+R+H%3BBazan%2C+NG%3BReiser%2C+J&rft.aulast=Kuroda&rft.aufirst=H&rft.date=2009-05-01&rft.volume=157&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2008.11.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Expression vectors; Transfection; Cell culture; Precipitation; Plasmids; pH effects; Calcium phosphate; Media (culture); Lentivirus DO - http://dx.doi.org/10.1016/j.jviromet.2008.11.021 ER - TY - JOUR T1 - Effectiveness of vertical visual reference for reducing postural instability on inclined and compliant surfaces at elevation AN - 20416929; 9090129 AB - Falls from elevation continue to be the most serious hazard for the workers in construction. Simple and cost effective technical approaches to improve workers' balance on sloped roofs and deformable/unstable platforms have potential to reduce the risk of falls. This study evaluated the effectiveness of simple vertical structures as visual references (cue) for balance improvement. Twenty-four construction workers were tested while standing on sloped and deformable surfaces at elevation and performing undemanding visual tasks with vertical structures positioned at different proximal locations. Workers' balance performance was assessed by sway parameters calculated from the center-of-pressure movement collected with a force platform. The study results indicate increased instability on the sloped and deformable surfaces at elevation, and show that a simple vertical structure, e.g., a narrow bar, can serve as a visual cue and assist workers' balance. Workers' balance improved linearly with cue proximity in the tested distance range both on the sloped and the deformable surfaces. At a moment of instability, workers can redirect their attention to a proximal structure, available in the line of sight, to assist balance control. These findings may be useful in modifying elevated work environments and construction procedures to improve workers' postural balance during various construction phases. JF - Applied Ergonomics AU - Simeonov, Peter AU - Hsiao, Hongwei AU - Hendricks, Scott AD - Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA, psimeonov@cdc.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 353 EP - 361 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 40 IS - 3 SN - 0003-6870, 0003-6870 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Fall prevention KW - Balance control KW - Visual reference KW - Roof construction KW - risk reduction KW - Ergonomics KW - working conditions KW - Construction industry KW - H 10000:Ergonomics/Human Factors KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20416929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Ergonomics&rft.atitle=Effectiveness+of+vertical+visual+reference+for+reducing+postural+instability+on+inclined+and+compliant+surfaces+at+elevation&rft.au=Simeonov%2C+Peter%3BHsiao%2C+Hongwei%3BHendricks%2C+Scott&rft.aulast=Simeonov&rft.aufirst=Peter&rft.date=2009-05-01&rft.volume=40&rft.issue=3&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Applied+Ergonomics&rft.issn=00036870&rft_id=info:doi/10.1016%2Fj.apergo.2008.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - risk reduction; Construction industry; working conditions; Ergonomics DO - http://dx.doi.org/10.1016/j.apergo.2008.11.007 ER - TY - JOUR T1 - Exposure to hazardous workplace noise and use of hearing protection devices among US workers - NHANES, 1999-2004 AN - 20136420; 10246801 AB - Background To estimate the prevalence of workplace noise exposure and use of hearing protection devices (HPDs) at noisy work, NIOSH analyzed 1999-2004 data from the National Health and Nutrition Examination Survey (NHANES). Methods A total of 9,275 currently employed workers aged 16 years were included in the weighted analysis. Hazardous workplace noise exposure was defined as self-reported exposure to noise at their current job that was so loud that the respondent had to speak in a raised voice to be heard. Industry and occupation were determined based on the respondent's current place and type of work. Results Twenty-two million US workers (17%) reported exposure to hazardous workplace noise. The weighted prevalence of workplace noise exposure was highest for mining (76%, SE = 7.0) followed by lumber/wood product manufacturing (55%, SE = 2.5). High-risk occupations included repair and maintenance, motor vehicle operators, and construction trades. Overall, 34% of the estimated 22 million US workers reporting hazardous workplace exposure reported non-use of HPDs. The proportion of noise-exposed workers who reported non-use of HPDs was highest for healthcare and social services (73.7%, SE = 8.1), followed by educational services (55.5%). Discussion Hearing loss prevention and intervention programs should be targeted at those industries and occupations identified to have a high prevalence of workplace noise exposure and those industries with the highest proportion of noise-exposed workers who reported non-use of HPDs. Am. J. Ind. Med. 52:358-371, 2009. Published 2009 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Tak, Sangwoo AU - Davis, Rickie R AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, stak@cdc.gov Y1 - 2009/05// PY - 2009 DA - May 2009 SP - 358 EP - 371 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 52 IS - 5 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Motor vehicles KW - Intervention KW - Nutrition KW - social services KW - Workers KW - intervention KW - prevention KW - Risk groups KW - Occupational exposure KW - Data processing KW - Lumber KW - Noise levels KW - Wood KW - Hearing loss KW - Maintenance KW - USA KW - Prevention KW - Health care KW - lumber KW - Noise KW - Mining KW - R2 23080:Industrial and labor KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20136420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Exposure+to+hazardous+workplace+noise+and+use+of+hearing+protection+devices+among+US+workers+-+NHANES%2C+1999-2004&rft.au=Tak%2C+Sangwoo%3BDavis%2C+Rickie+R%3BCalvert%2C+Geoffrey+M&rft.aulast=Tak&rft.aufirst=Sangwoo&rft.date=2009-05-01&rft.volume=52&rft.issue=5&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20690 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Workers; Data processing; Motor vehicles; Noise; Risk groups; Hearing loss; Nutrition; Occupational exposure; Lumber; Noise levels; Wood; Intervention; Maintenance; social services; Prevention; Health care; intervention; prevention; lumber; Mining; USA DO - http://dx.doi.org/10.1002/ajim.20690 ER - TY - JOUR T1 - Organ-specific warnings; internal analgesic, antipyretic, and antirheumatic drug products for over-the-counter human use; final monograph. Final rule. AN - 67353741; 19507324 AB - The Food and Drug Administration (FDA) is issuing this final rule to require important new organ-specific warnings and related labeling for over-the-counter (OTC) internal analgesic, antipyretic, and antirheumatic (IAAA) drug products. The new labeling informs consumers about the risk of liver injury when using acetaminophen and the risk of stomach bleeding when using nonsteroidal anti-inflammatory drugs (NSAIDS). The new labeling is required for all OTC IAAA drug products whether marketed under an OTC drug monograph or an approved new drug application (NDA). JF - Federal register AU - Food and Drug Administration, HHS AD - Food and Drug Administration, HHS Y1 - 2009/04/29/ PY - 2009 DA - 2009 Apr 29 SP - 19385 EP - 19409 VL - 74 IS - 81 SN - 0097-6326, 0097-6326 KW - Analgesics KW - 0 KW - Analgesics, Non-Narcotic KW - Antirheumatic Agents KW - Nonprescription Drugs KW - Health technology assessment KW - United States KW - Humans KW - Legislation, Drug KW - Consumer Product Safety -- legislation & jurisprudence KW - Analgesics, Non-Narcotic -- adverse effects KW - Nonprescription Drugs -- adverse effects KW - Antirheumatic Agents -- adverse effects KW - Drug Labeling -- legislation & jurisprudence KW - Viscera -- drug effects KW - Analgesics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67353741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+register&rft.atitle=Organ-specific+warnings%3B+internal+analgesic%2C+antipyretic%2C+and+antirheumatic+drug+products+for+over-the-counter+human+use%3B+final+monograph.+Final+rule.&rft.au=Food+and+Drug+Administration%2C+HHS&rft.aulast=Food+and+Drug+Administration&rft.aufirst=HHS&rft.date=2009-04-29&rft.volume=74&rft.issue=81&rft.spage=19385&rft.isbn=&rft.btitle=&rft.title=Federal+register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-12 N1 - Date created - 2009-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway. AN - 733092907; 19379505 AB - Carcinogenicity of nickel compounds has been well documented. However, the carcinogenic effect of metallic nickel is still unclear. The present study investigates metallic nickel nano- and fine particle-induced apoptosis and the signal pathways involved in this process in JB6 cells. The data obtained from this study will be of benefit for elucidating the pathological and carcinogenic potential of metallic nickel particles. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, we found that metallic nickel nanoparticles exhibited higher cytotoxicity than fine particles. Both metallic nickel nano- and fine particles induced JB6 cell apoptosis. Metallic nickel nanoparticles produced higher apoptotic induction than fine particles. Western-blot analysis showed an activation of proapoptotic factors including Fas (CD95), Fas-associated protein with death domain (FADD), caspase-8, death receptor 3 (DR3) and BID in apoptotic cells induced by metallic nickel particles. Immunoprecipitation (IP) western blot analysis demonstrated the formation of the Fas-related death-inducing signaling complex (DISC) in the apoptotic process. Furthermore, lamin A and beta-actin were cleaved. Moreover, we found that apoptosis-inducing factor (AIF) was up-regulated and released from mitochondria to cytoplasm. Interestingly, although an up-regulation of cytochrome c was detected in the mitochondria of metallic nickel particle-treated cells, no cytochrome c release from mitochondria to cytoplasm was found. In addition, activation of antiapoptotic factors including phospho-Akt (protein kinase B) and Bcl-2 was detected. Further studies demonstrated that metallic nickel particles caused no significant changes in the mitochondrial membrane permeability after 24 h treatment. In this study, metallic nickel nanoparticles caused higher cytotoxicity and apoptotic induction than fine particles in JB6 cells. Apoptotic cell death induced by metallic nickel particles in JB6 cells is through a caspase-8/AIF mediated cytochrome c-independent pathway. Lamin A and beta-actin are involved in the process of apoptosis. Activation of Akt and Bcl-2 may play an important role in preventing cytochrome c release from mitochondria to the cytoplasm and may also be important in the carcinogenicity of metallic nickel particles. In addition, the results may be useful as an important reference when comparing the toxicities of different nickel compounds. JF - Journal of nanobiotechnology AU - Zhao, Jinshun AU - Bowman, Linda AU - Zhang, Xingdong AU - Shi, Xianglin AU - Jiang, Binghua AU - Castranova, Vincent AU - Ding, Min AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA. mid5@cdc.gov. Y1 - 2009/04/20/ PY - 2009 DA - 2009 Apr 20 SP - 2 VL - 7 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733092907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nanobiotechnology&rft.atitle=Metallic+nickel+nano-+and+fine+particles+induce+JB6+cell+apoptosis+through+a+caspase-8%2FAIF+mediated+cytochrome+c-independent+pathway.&rft.au=Zhao%2C+Jinshun%3BBowman%2C+Linda%3BZhang%2C+Xingdong%3BShi%2C+Xianglin%3BJiang%2C+Binghua%3BCastranova%2C+Vincent%3BDing%2C+Min&rft.aulast=Zhao&rft.aufirst=Jinshun&rft.date=2009-04-20&rft.volume=7&rft.issue=&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Journal+of+nanobiotechnology&rft.issn=1477-3155&rft_id=info:doi/10.1186%2F1477-3155-7-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-04-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cytotechnology. 2004 Oct;46(2-3):139-50 [19003268] Crit Rev Eukaryot Gene Expr. 1999;9(3-4):285-93 [10651245] Carcinogenesis. 2008 Jun;29(6):1276-81 [18375956] Environ Health Perspect. 2007 Nov;115(11):1631-7 [18007996] J Med Microbiol. 2007 Oct;56(Pt 10):1399-404 [17893180] Biochem J. 2007 Apr 15;403(2):323-34 [17168856] Regul Toxicol Pharmacol. 2005 Nov;43(2):117-33 [16129532] Cell Death Differ. 2006 Sep;13(9):1423-33 [16676004] Mol Pharmacol. 2006 Aug;70(2):589-603 [16622074] Mol Cell Biochem. 2005 Nov;279(1-2):45-67 [16283514] Nat Rev Mol Cell Biol. 2005 Jul;6(7):583-9 [16072039] EMBO J. 2005 Apr 6;24(7):1375-86 [15775970] Transplantation. 2005 Apr 15;79(7):842-5 [15818328] Am J Physiol. 1998 Jun;274(6 Pt 1):G1117-24 [9696713] Cell. 1998 Aug 21;94(4):481-90 [9727491] Mol Cell Biol. 1999 Aug;19(8):5800-10 [10409766] Curr Opin Cell Biol. 1999 Apr;11(2):255-60 [10209153] Oncogene. 1999 Apr 15;18(15):2423-30 [10229193] Nature. 1999 Feb 4;397(6718):441-6 [9989411] Am J Respir Cell Mol Biol. 1999 Jan;20(1):53-60 [9870917] Carcinogenesis. 1998 Jul;19(7):1203-7 [9683178] Physiol Rev. 1998 Jul;78(3):763-81 [9674694] Science. 1995 Mar 10;267(5203):1445-9 [7878463] Environ Health Perspect. 1994 Oct;102 Suppl 5:173-9 [7882925] Toxicol Lett. 1994 Jun;72(1-3):353-8 [8202952] Crit Rev Toxicol. 1989;19(4):341-84 [2663022] Toxicology. 1989 Aug;57(3):255-66 [2756527] Toxicol Lett. 2004 Dec 1;154(1-2):23-34 [15475175] Mutat Res. 2003 Dec 10;533(1-2):67-97 [14643413] J Occup Health. 2003 Jan;45(1):23-30 [14605425] Eur J Cell Biol. 2002 Dec;81(12):677-91 [12553668] Toxicol Appl Pharmacol. 2002 Nov 15;185(1):41-7 [12460735] J Cell Sci. 2002 Dec 15;115(Pt 24):4727-34 [12432061] Science. 2002 May 31;296(5573):1635-6 [12040174] Carcinogenesis. 2002 Jan;23(1):143-50 [11756235] Am J Respir Cell Mol Biol. 2001 Mar;24(3):282-94 [11245627] Am J Pathol. 2001 Jan;158(1):153-61 [11141488] J Exp Med. 2000 Aug 21;192(4):571-80 [10952727] Cell Death Differ. 2008 Oct;15(10):1553-63 [18535584] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1477-3155-7-2 ER - TY - CPAPER T1 - Defense against toxic metals and hyperglycemia by Nrf2 T2 - 2009 Conference on Experimental Biology AN - 40376599; 5289519 JF - 2009 Conference on Experimental Biology AU - Ma, Q. Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Heavy metals KW - Hyperglycemia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40376599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=Defense+against+toxic+metals+and+hyperglycemia+by+Nrf2&rft.au=Ma%2C+Q.&rft.aulast=Ma&rft.aufirst=Q.&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Moving pharmacogenomics into mainstream medicine T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40365337; 5270724 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Zineh, Issam Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Pharmacogenomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40365337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Moving+pharmacogenomics+into+mainstream+medicine&rft.au=Zineh%2C+Issam&rft.aulast=Zineh&rft.aufirst=Issam&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090418.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Careers in Cancer, Government T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40358033; 5273954 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Lyn-Cook, Beverly Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Cancer KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40358033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Careers+in+Cancer%2C+Government&rft.au=Lyn-Cook%2C+Beverly&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090420.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patient advocate presentation T2 - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AN - 40348412; 5271734 JF - 100th Annual Meeting of the American Association for Cancer Research (AACR 2009) AU - Mayer, Musa Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.atitle=Patient+advocate+presentation&rft.au=Mayer%2C+Musa&rft.aulast=Mayer&rft.aufirst=Musa&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=100th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/Uploads/DocumentRepository/2009_AM/am09_final_prog ram_20090419.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of a rapid analytical method for identifying closely related Yersinia species to provide a procedure for food safety and security T2 - 2009 Conference on Experimental Biology AN - 40286933; 5231849 JF - 2009 Conference on Experimental Biology AU - Whittaker, P Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Security KW - Food contamination KW - Food KW - Public health KW - Yersinia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40286933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=Use+of+a+rapid+analytical+method+for+identifying+closely+related+Yersinia+species+to+provide+a+procedure+for+food+safety+and+security&rft.au=Whittaker%2C+P&rft.aulast=Whittaker&rft.aufirst=P&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vibration-induced changes in oxidative stress and expression of inflammatory factors are frequency dependent T2 - 2009 Conference on Experimental Biology AN - 40273432; 5230051 JF - 2009 Conference on Experimental Biology AU - Krajnak, K AU - Waugh, S AU - Miller, R AU - Johnson, C AU - Kashon, M Y1 - 2009/04/18/ PY - 2009 DA - 2009 Apr 18 KW - Oxidative stress KW - Inflammation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40273432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Experimental+Biology&rft.atitle=Vibration-induced+changes+in+oxidative+stress+and+expression+of+inflammatory+factors+are+frequency+dependent&rft.au=Krajnak%2C+K%3BWaugh%2C+S%3BMiller%2C+R%3BJohnson%2C+C%3BKashon%2C+M&rft.aulast=Krajnak&rft.aufirst=K&rft.date=2009-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Experimental+Biology&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/eb2009/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cause-Specific Mortality in Long-Term Survivors of Retinoblastoma AN - 20593789; 9300767 AB - Background Subsequent malignant neoplasms are a major cause of premature death in survivors of hereditary retinoblastoma. Radiotherapy further increases the risk of death. Mortality information is limited among long-term survivors who were irradiated for hereditary retinoblastoma.Methods We examined cause-specific mortality among 1854 retinoblastoma survivors who were diagnosed from January 1, 1914, through December 31, 1996, at two US institutions. Standardized mortality ratios (SMRs) were calculated by use of US mortality data to estimate expected numbers of deaths. The relative rates (RRs) of mortality due to subsequent malignant neoplasms associated with multiple risk factors were evaluated with Poisson regression models. Cumulative mortality from subsequent malignant neoplasms was calculated by treating other causes of death as competing risks.Results A total of 151 deaths due to subsequent malignant neoplasms occurred among 1092 hereditary retinoblastoma survivors (SMR = 35, 95% confidence interval [CI] = 30 to 41) compared with 12 deaths among 762 nonhereditary retinoblastoma survivors (SMR = 2.5, 95% CI = 1.3 to 4.4). In this extended follow-up of retinoblastoma survivors, we found no evidence of excess mortality from non-neoplastic causes compared with the general population. However, excess mortality from subsequent malignant neoplasms (particularly sarcomas, melanomas, and cancers of the brain and other parts of the nervous system) among hereditary retinoblastoma survivors extended beyond 40 years after retinoblastoma diagnosis. The additional 13 years of follow-up since our last mortality study revealed a previously unreported increased risk of death due to cancers of the corpus uteri (primarily sarcomas) and confirmed the previously reported elevated risk of death from lung cancer among hereditary retinoblastoma survivors. Among hereditary and nonhereditary retinoblastoma survivors, the relative rates of mortality from subsequent malignant neoplasm were higher in those who had been treated with radiotherapy than in those who had not. Cumulative mortality from subsequent malignant neoplasms at 50 years after retinoblastoma diagnosis was 25.5% (95% CI = 20.8% to 30.2%) for hereditary retinoblastoma survivors and 1.0% (95% CI = 0.2% to 1.8%) for nonhereditary retinoblastoma survivors.Conclusions The temporal patterns of site-specific excess risks of subsequent malignant neoplasms in retinoblastoma survivors should inform screening programs designed for the early detection and treatment of subsequent malignant neoplasms. JF - Journal of the National Cancer Institute AU - Yu, Chu-Ling AU - Tucker, Margaret A AU - Abramson, David H AU - Furukawa, Kyoji AU - Seddon, Johanna M AU - Stovall, Marilyn AU - Fraumeni, Joseph F AU - Kleinerman, Ruth A AD - Affiliations of authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD (C-LY, MAT, JFF, RAK); Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY (DHA); Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan (KF); Ophthalmic Epidemiology & Genetics Service, Tufts-New England Medical Center, Boston, MA (JMS); Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (MS), yuchu@mail.nih.gov Y1 - 2009/04/15/ PY - 2009 DA - 2009 Apr 15 SP - 581 EP - 591 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 101 IS - 8 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - Brain KW - Standards KW - melanoma KW - radiotherapy KW - Cancer KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20593789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Cause-Specific+Mortality+in+Long-Term+Survivors+of+Retinoblastoma&rft.au=Yu%2C+Chu-Ling%3BTucker%2C+Margaret+A%3BAbramson%2C+David+H%3BFurukawa%2C+Kyoji%3BSeddon%2C+Johanna+M%3BStovall%2C+Marilyn%3BFraumeni%2C+Joseph+F%3BKleinerman%2C+Ruth+A&rft.aulast=Yu&rft.aufirst=Chu-Ling&rft.date=2009-04-15&rft.volume=101&rft.issue=8&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Brain; Standards; melanoma; radiotherapy; Cancer; Lung cancer DO - http://dx.doi.org/10.1093/jnci/djp046 ER - TY - JOUR T1 - Comparison of the diagnostic performance of human whole genome microarrays using mixed-tissue RNA reference samples AN - 20404606; 9083236 AB - Universal approaches for assessing the diagnostic performance of microarray assays are essential for the application of microarray technology to clinical and regulatory settings. Reference systems for diagnostic assays in laboratory medicine typically involve the utilization of reference samples, metrics, and reference datasets to ensure that measurements are comparable and true. For microarray performance evaluation and process improvement, reference samples can be composed of mixes of different tissue or cell line RNAs that contain tissue-selective analytes at defined target ratios. The diagnostic accuracy of detected changes in expression, measured as the area under the curve from receiver-operating characteristic plots, can provide a single commutable value for comparing assay specificity and sensitivity. Examples of applying this method for assessing overall performance are provided using public datasets generated on five commercial human whole genome microarray platforms for the MicroArray Quality Control project, a community-wide effort to address issues surrounding microarray data reliability. JF - Toxicology Letters AU - Thompson, K L AU - Pine, P S AD - US Food and Drug Administration, Silver Spring, MD, USA, karol.thompson@fda.hhs.gov Y1 - 2009/04/10/ PY - 2009 DA - 2009 Apr 10 SP - 58 EP - 61 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 186 IS - 1 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Genomes KW - Data processing KW - RNA KW - Quality control KW - G 07730:Development & Cell Cycle KW - N 14810:Methods KW - W 30900:Methods KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20404606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Comparison+of+the+diagnostic+performance+of+human+whole+genome+microarrays+using+mixed-tissue+RNA+reference+samples&rft.au=Thompson%2C+K+L%3BPine%2C+P+S&rft.aulast=Thompson&rft.aufirst=K&rft.date=2009-04-10&rft.volume=186&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2008.08.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; RNA; Quality control DO - http://dx.doi.org/10.1016/j.toxlet.2008.08.018 ER - TY - JOUR T1 - An FDA perspective on the nonclinical use of the X-Omics technologies and the safety of new drugs AN - 20400402; 9083235 AB - Work in the field ''omics'' (toxicogenomics, proteomics, and metabolomics) has exploded. It is hoped that 'omics' could be a tool for evaluation of general toxicology, reproductive toxicology, the carcinogenicity potential of pharmaceuticals and several other types of toxicity, eventually replacing the use of animals. Although much progress has been made in the standardization of procedures, challenges remain for evaluation of pharmaceuticals for regulatory purposes, because of off-target toxicologic effects, as well as issues of interpretation and the large number of biologic variables that can affect results. Such variables include species /strain, genetic variations, diet, age, dose, duration, and weight of animals. These variables also confound database compilations of expression profiles. The most promising use in the near future would be to clarify pathways for the various types of toxicity and carcinogenicity and get biomarkers for these pathways, to help assess relevance of nonclinical findings to humans. JF - Toxicology Letters AU - Jacobs, A AD - 10903 New Hampshire Ave Blg 22, Rm 6484, Silver Spring, MD 20993-0002, United States, abigail.jacobs@fda.hhs.gov Y1 - 2009/04/10/ PY - 2009 DA - 2009 Apr 10 SP - 32 EP - 35 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 186 IS - 1 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Diets KW - Databases KW - Standardization KW - Age KW - Carcinogenicity KW - Pharmaceuticals KW - Toxicity KW - proteomics KW - biomarkers KW - Drugs KW - metabolomics KW - X 24310:Pharmaceuticals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20400402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=An+FDA+perspective+on+the+nonclinical+use+of+the+X-Omics+technologies+and+the+safety+of+new+drugs&rft.au=Jacobs%2C+A&rft.aulast=Jacobs&rft.aufirst=A&rft.date=2009-04-10&rft.volume=186&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2008.08.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Standardization; Databases; Age; Carcinogenicity; Pharmaceuticals; proteomics; Toxicity; Drugs; biomarkers; metabolomics DO - http://dx.doi.org/10.1016/j.toxlet.2008.08.013 ER - TY - RPRT T1 - Nonmedical Use of Adderall[R] among Full-Time College Students. The NSDUH Report AN - 964177916; ED525060 AB - This issue of "The NSDUH Report" examines the rates of nonmedical use of Adderall[R] in the past year among full-time college students aged 18 to 22 and comparably aged persons who were not full-time college students. All findings presented in this report are annual averages based on combined 2006 and 2007 data. Full-time college students aged 18 to 22 were twice as likely as their counterparts who were not full-time college students to have used Adderall[R] nonmedically in the past year (6.4 vs. 3.0 percent). Full-time college students who were nonmedical users of Adderall[R] were almost 3 times as likely as those who had not used Adderall[R] nonmedically to have used marijuana in the past year (79.9 vs. 27.2 percent), 8 times more likely to have used cocaine in that period (28.9 vs. 3.6 percent), 8 times more likely to have been nonmedical users of prescription tranquilizers (24.5 vs. 3.0 percent), and 5 times more likely to have been nonmedical users of prescription pain relievers (44.9 vs. 8.7 percent). Nearly 90 percent of full-time college students who used Adderall[R] nonmedically in the past year were past month binge alcohol users, and more than half were heavy alcohol users. (Contains 3 figures, 1 table and 7 endnotes.) Y1 - 2009/04/07/ PY - 2009 DA - 2009 Apr 07 SP - 4 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Higher Education KW - Postsecondary Education KW - Alcohol Abuse KW - Student Characteristics KW - Full Time Students KW - Incidence KW - College Students KW - Narcotics KW - Stimulants KW - Cocaine KW - Marijuana KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964177916?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Determination of cyanuric acid residues in catfish, trout, tilapia, salmon and shrimp by liquid chromatography-tandem mass spectrometry AN - 896211478; 15119385 AB - In May 2007, investigators discovered that waste material from the pet food manufacturing process contaminated with melamine (MEL) and/or cyanuric acid (CYA) had been added to hog and chicken feeds. At this time, investigators also learned that adulterated wheat gluten had been used in the manufacture of aquaculture feeds. Concern that the contaminated feed had been used in aquaculture and could enter the human food supply prompted the development of a method for the determination of CYA residues in the edible tissues of fish and shrimp. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed as a sensitive technique for the analysis of CYA in catfish, tilapia, salmon, trout and shrimp tissue. CYA was extracted from ground fish or shrimp with an acetic acid solution, defatted with hexane, and isolated with a graphitic carbon black solid-phase extraction column. Residues were separated from matrix components using a porous graphitic carbon LC column, and then analyzed with electrospray ionization in negative ion mode on a triple quadrupole mass spectrometer. Selective reaction monitoring was performed on the [M-H][super]- m/z 128 ion resulting in the product ions m/z 85 and 42. Recoveries from catfish, tilapia and trout fortified with 10-100 [micro]g kg[super]-1 of CYA averaged 67% with a relative standard deviation (R.S.D.) of 18% (n = 107). The average method detection limit (MDL) for catfish, tilapia and trout is 3.5 [micro]g kg[super]-1. An internal standard, [super]13C sub(3-labeled CYA, was used in the salmon and shrimp extractions. Average recovery of CYA from salmon was 91% (R.S.D. = 15%, n = 18) with an MDL of 7.4 [micro]g kg[super]-1. Average recovery of CYA from shrimp was 85% (R.S.D. = 10%, n = 13) with an MDL of 3.5 [micro]g kg[super]-1.) JF - Analytica Chimica Acta AU - Karbiwnyk, Christine M AU - Andersen, Wendy C AU - Turnipseed, Sherri B AU - Storey, Joseph M AU - Madson, Mark R AU - Miller, Keith E AU - Gieseker, Charles M AU - Miller, Ron A AU - Rummel, Nathan G AU - Reimschuessel, Renate Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 101 EP - 111 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 637 IS - 1-2 SN - 0003-2670, 0003-2670 KW - ASFA 1: Biological Sciences & Living Resources; ASFA Aquaculture Abstracts; Environment Abstracts KW - Cyanuric acid KW - Melamine KW - Liquid chromatography-tandem mass spectrometry KW - Fish KW - Shrimp KW - Aquaculture effluents KW - Livestock food KW - Food supply KW - Residues KW - Fish wastes KW - Anadromous species KW - Human food KW - Mass spectrometry KW - Tilapia KW - Aquaculture KW - Mass spectroscopy KW - Triticum aestivum KW - black carbon KW - Aquaculture development KW - salmon KW - melamine KW - Salmonidae KW - Fish culture KW - Feeds KW - Q1 08626:Food technology KW - Q3 08588:Effects of Aquaculture on the Environment KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896211478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+Chimica+Acta&rft.atitle=Determination+of+cyanuric+acid+residues+in+catfish%2C+trout%2C+tilapia%2C+salmon+and+shrimp+by+liquid+chromatography-tandem+mass+spectrometry&rft.au=Karbiwnyk%2C+Christine+M%3BAndersen%2C+Wendy+C%3BTurnipseed%2C+Sherri+B%3BStorey%2C+Joseph+M%3BMadson%2C+Mark+R%3BMiller%2C+Keith+E%3BGieseker%2C+Charles+M%3BMiller%2C+Ron+A%3BRummel%2C+Nathan+G%3BReimschuessel%2C+Renate&rft.aulast=Karbiwnyk&rft.aufirst=Christine&rft.date=2009-04-01&rft.volume=637&rft.issue=1-2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Analytica+Chimica+Acta&rft.issn=00032670&rft_id=info:doi/10.1016%2Fj.aca.2008.08.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Livestock food; Aquaculture development; Fish wastes; Anadromous species; Human food; melamine; Mass spectroscopy; Fish culture; Aquaculture effluents; Food supply; black carbon; Residues; Mass spectrometry; salmon; Fish; Aquaculture; Feeds; Triticum aestivum; Tilapia; Salmonidae DO - http://dx.doi.org/10.1016/j.aca.2008.08.037 ER - TY - JOUR T1 - Oxidative and Excitatory Mechanisms of Developmental Neurotoxicity: Transcriptional Profiles for Chlorpyrifos, Diazinon, Dieldrin, and Divalent Nickel in PC12 Cells AN - 743584904; 201004-31-0310877 (CE); 12116985 (EN) AB - BACKGROUND: Oxidative stress and excitotoxicity underlie the developmental neurotoxicity of numerous chemicals. OBJECTIVES: We compared the effects of organophosphates (chlorpyrifos and diazinon), an organo-chlorine (dieldrin), and a metal [divalent nickel (Ni2+)] to determine how these mechanisms contribute to similar or dissimilar neurotoxic outcomes. METHODS: We used PC12 cells as a model of developing neurons and evaluated transcriptional profiles for genes for oxidative stress responses and glutamate receptors. RESULTS: Chlorpyrifos had a greater effect on oxidative-stress-related genes in differentiating cells compared with the undifferentiated state. Chlorpyrifos and diazinon showed significant concordance in their effects on glutathione-related genes, but they were negatively correlated for effects on catalase and superoxide dismutase isoforms and had no concordance for effects on ionotropic glutamate receptors. Surprisingly, the correlations were stronger between diazinon and dieldrin than between the two organophosphates. The effects of Ni2+ were the least similar for genes related to oxidative stress but had significant concordance with dieldrin for effects on glutamate receptors. CONCLUSIONS: Our results point to underlying mechanisms by which different organophosphates produce disparate neurotoxic outcomes despite their shared property as cholinesterase inhibitors. Further, apparently unrelated neurotoxicants may produce similar outcomes because of convergence on oxidative stress and excitotoxicity. The combined use of cell cultures and microarrays points to specific end points that can distinguish similarities and disparities in the effects of diverse developmental neurotoxicants. JF - Environmental Health Perspectives AU - Slotkin, Theodore A AU - Seidler, Frederic J PY - 2009 SP - 587 EP - 596 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Chlorpyrifos KW - Dieldrin KW - Genes KW - Stresses KW - Receptors KW - Excitation KW - Glutamates KW - Organophosphates KW - Inhibitors KW - Nickel KW - Correlation KW - Health KW - Catalase KW - Culture KW - Mathematical models KW - Superoxide dismutase KW - Copyrights KW - Dissimilar metals KW - Neurons KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743584904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Oxidative+and+Excitatory+Mechanisms+of+Developmental+Neurotoxicity%3A+Transcriptional+Profiles+for+Chlorpyrifos%2C+Diazinon%2C+Dieldrin%2C+and+Divalent+Nickel+in+PC12+Cells&rft.au=Slotkin%2C+Theodore+A%3BSeidler%2C+Frederic+J&rft.aulast=Slotkin&rft.aufirst=Theodore&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Exposure to Bisphenol A and Other Phenols in Neonatal Intensive Care Unit Premature Infants AN - 743575599; 201004-31-0310870 (CE); 12116978 (EN) AB - OBJECTIVE: We previously demonstrated that exposure to polyvinyl chloride plastic medical devices containing di(2-ethylhexyl) phthalate (DEHP) was associated with higher urinary concentrations of several DEHP metabolites in 54 premature infants in two neonatal intensive care units than in the general population. For 42 of these infants, we evaluated urinary concentrations of several phenols, including bisphenol A (BPA), in association with the use of the same medical devices. MEASUREMENTS: We measured the urinary concentrations of free and total (free plus conjugated) species of BPA, triclosan, benzophenone-3, methyl paraben, and propyl paraben. RESULTS: The percentage of BPA present as its conjugated species was 90% in more than three-quarters of the premature infants. Intensity of use of products containing DEHP was strongly associated with BPA total concentrations but not with any other phenol. Adjusting for institution and sex, BPA total concentrations among infants in the group of high use of DEHP-containing products were 8.75 times as high as among infants in the low use group (p 0.0001). Similarly, after adjusting for sex and DEHP-containing product use category, BPA total concentrations among infants in Institution A were 16.6 times as high as those among infants in Institution B (p 0.0001). CONCLUSION: BPA geometric mean urinary concentration (30.3 microg/L) among premature infants undergoing intensive therapeutic medical interventions was one order of magnitude higher than that among the general population. Conjugated species were the primary urinary metabolites of BPA, suggesting that premature infants have some capacity to metabolize BPA. The differences in exposure to BPA by intensity of use of DEHP-containing medical products highlight the need for further studies to determine the specific source(s) of exposure to BPA. JF - Environmental Health Perspectives AU - Calafat, Antonia M AU - Weuve, Jennifer AU - Ye, Xiaoyun AU - Jia, Lily T AU - Hu, Howard AU - Ringer, Steven AU - Huttner, Ken AU - Hauser, Russ PY - 2009 SP - 639 EP - 644 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Infants KW - Phenols KW - Surgical implants KW - Metabolites KW - Sex KW - Health KW - Medical KW - Bisphenol A KW - Polyvinyl chlorides KW - Copyrights KW - Categories KW - Phthalates KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743575599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+to+Bisphenol+A+and+Other+Phenols+in+Neonatal+Intensive+Care+Unit+Premature+Infants&rft.au=Calafat%2C+Antonia+M%3BWeuve%2C+Jennifer%3BYe%2C+Xiaoyun%3BJia%2C+Lily+T%3BHu%2C+Howard%3BRinger%2C+Steven%3BHuttner%2C+Ken%3BHauser%2C+Russ&rft.aulast=Calafat&rft.aufirst=Antonia&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Toxicity of Tungsten Carbide and Cobalt-Doped Tungsten Carbide Nanoparticles in Mammalian Cells in Vitro AN - 743542433; 201004-31-0310885 (CE); 12116993 (EN) AB - BACKGROUND: Tungsten carbide nanoparticles are being explored for their use in the manufacture of hard metals. To develop nanoparticles for broad applications, potential risks to human health and the environment should be evaluated and taken into consideration. OBJECTIVE: We aimed to assess the toxicity of well-characterized tungsten carbide (WC) and cobalt-doped tungsten carbide (WC-Co) nanoparticle suspensions in an array of mammalian cells. METHODS: We examined acute toxicity of WC and of WC-Co (10% weight content Co) nanoparticles in different human cell lines (lung, skin, and colon) as well as in rat neuronal and glial cells (i.e., primary neuronal and astroglial cultures and the oligodendrocyte precursor cell line OLN-93). Furthermore, using electron microscopy, we assessed whether nanoparticles can be taken up by living cells. We chose these in vitro systems in order to evaluate for potential toxicity of the nanoparticles in different mammalian organs (i.e., lung, skin, intestine, and brain). RESULTS: Chemical-physical characterization confirmed that WC as well as WC-Co nanoparticles with a mean particle size of 145 nm form stable suspensions in serum-containing cell culture media. WC nanoparticles were not acutely toxic to the studied cell lines. However, cytotoxicity became apparent when particles were doped with Co. The most sensitive were astrocytes and colon epithelial cells. Cytotoxicity of WC-Co nanoparticles was higher than expected based on the ionic Co content of the particles. Analysis by electron microscopy demonstrated presence of WC nanoparticles within mammalian cells. CONCLUSIONS: Our findings demonstrate that doping of WC nanoparticles with Co markedly increases their cytotoxic effect and that the presence of WC-Co in particulate form is essential to elicit this combinatorial effect. JF - Environmental Health Perspectives AU - Bastian, Susanne AU - Busch, Wibke AU - Kuehnel, Dana AU - Springer, Armin AU - Meissner, Tobias AU - Holke, Roland AU - Scholz, Stefan AU - Iwe, Maria AU - Pompe, Wolfgang AU - Gelinsky, Michael AU - Potthoff, Annegret AU - Richter, Volkmar AU - Ikonomidou, Chrysanthy AU - Schirmer, Kristin PY - 2009 SP - 530 EP - 536 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Nanoparticles KW - Tungsten carbide KW - Cemented carbides KW - Cobalt KW - Toxicity KW - Combinatorial analysis KW - Health KW - Colon KW - In vitro testing KW - Culture KW - Lungs KW - Human KW - Electron microscopy KW - Arrays KW - Risk KW - Doping KW - Toxic KW - Media KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743542433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Toxicity+of+Tungsten+Carbide+and+Cobalt-Doped+Tungsten+Carbide+Nanoparticles+in+Mammalian+Cells+in+Vitro&rft.au=Bastian%2C+Susanne%3BBusch%2C+Wibke%3BKuehnel%2C+Dana%3BSpringer%2C+Armin%3BMeissner%2C+Tobias%3BHolke%2C+Roland%3BScholz%2C+Stefan%3BIwe%2C+Maria%3BPompe%2C+Wolfgang%3BGelinsky%2C+Michael%3BPotthoff%2C+Annegret%3BRichter%2C+Volkmar%3BIkonomidou%2C+Chrysanthy%3BSchirmer%2C+Kristin&rft.aulast=Bastian&rft.aufirst=Susanne&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Time- and Dose-Related Effects of Di-(2-ethylhexyl) Phthalate and Its Main Metabolites on the Function of the Rat Fetal Testis in Vitro AN - 743530324; 201004-31-0310887 (CE); 12116995 (EN) AB - BACKGROUND: Endocrine-disrupting effects of phthalates are understood primarily from in utero exposures within the fetal rat testis. Nevertheless, their path of action, dose-response character, and cellular target(s) within the fetal testis are not known. OBJECTIVES: In this study we investigated the effects of di-(2-ethylhexyl) phthalate (DEHP), mono-(2-ethylhexyl) phthalate (MEHP), and several of their metabolites on the development of organo-cultured testes from rat fetus. METHODS: We removed testes from 14.5-day-old rat fetuses and cultured them for 1-3 days with or without DEHP, MEHP, and the metabolites. RESULTS: DEHP (10(-5) M) produced a proandrogenic effect after 3 days of culture, whereas MEHP disrupted testis morphology and function. Leydig cells were the first affected by MEHP, with a number of them being inappropriately located within some seminiferous tubules. Additionally, we found a time- and dose-dependent reduction of testosterone. By 48 hr, gonocyte proliferation had decreased, whereas apoptosis increased. Sertoli cell number was unaffected, although some cells appeared vacuolated, and production of anti-Muellerian hormone decreased in a time- and dose-dependent manner. The derived metabolite mono-(2-ethyl-5-hydroxyhexyl) phthalate was the only one to cause deleterious effects to the rat fetal testis in vitro. CONCLUSION: We hope that this in vitro method will facilitate the study of different phthalate esters and other endocrine disruptors for direct testicular effects. JF - Environmental Health Perspectives AU - Chauvigne, Francois AU - Menuet, Arnaud AU - Lesne, Laurianne AU - Chagnon, Marie-Christine AU - Chevrier, Cecile AU - Regnier, Jean-Francois AU - Angerer, Juergen AU - Jegou, Bernard PY - 2009 SP - 515 EP - 521 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Phthalates KW - Metabolites KW - In vitro testing KW - Testes KW - Health KW - Esters KW - Culture KW - Copyrights KW - Fetuses KW - Testosterone KW - Hormones KW - Cellular KW - Exposure KW - Reduction KW - Endocrine disruptors KW - Apoptosis KW - Morphology KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743530324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Time-+and+Dose-Related+Effects+of+Di-%282-ethylhexyl%29+Phthalate+and+Its+Main+Metabolites+on+the+Function+of+the+Rat+Fetal+Testis+in+Vitro&rft.au=Chauvigne%2C+Francois%3BMenuet%2C+Arnaud%3BLesne%2C+Laurianne%3BChagnon%2C+Marie-Christine%3BChevrier%2C+Cecile%3BRegnier%2C+Jean-Francois%3BAngerer%2C+Juergen%3BJegou%2C+Bernard&rft.aulast=Chauvigne&rft.aufirst=Francois&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Relationship of Housing and Population Health: A 30-Year Retrospective Analysis AN - 743515922; 201004-31-0310876 (CE); 12116984 (EN) AB - OBJECTIVE: We analyzed the relationship between health status and housing quality over time. METHODS: We combined data from two nationally representative longitudinal surveys of the U.S. population and its housing, the National Health and Nutrition Examination Survey and the American Housing Survey, respectively. We identified housing and health trends from approximately 1970 to 2000, after excluding those trends for which data were missing or where we found no plausible association or change in trend. RESULTS: Changes in housing include construction type, proportion of rental versus home ownership, age, density, size, moisture, pests, broken windows, ventilation and air conditioning, and water leaks. Changes in health measures include asthma, respiratory illness, obesity and diabetes, and lead poisoning, among others. The results suggest ecologic trends in childhood lead poisoning follow housing age, water leaks, and ventilation; asthma follows ventilation, windows, and age; overweight trends follow ventilation; blood pressure trends follow community measures; and health disparities have not changed greatly. CONCLUSIONS: Housing trends are consistent with certain health trends over time. Future national longitudinal surveys should include health, housing, and community metrics within a single integrated design, instead of separate surveys, in order to develop reliable indicators of how housing changes affect population health and how to best target resources. Little progress has been made in reducing the health and housing disparities of disadvantaged groups, with the notable exception of childhood lead poisoning caused by exposure to lead-based paint hazards. Use of these and other data sets to create reliable integrated indicators of health and housing quality are needed. JF - Environmental Health Perspectives AU - Jacobs, David E AU - Wilson, Jonathan AU - Dixon, Sherry L AU - Smith, Janet AU - Evens, Anne PY - 2009 SP - 597 EP - 604 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Housing KW - Trends KW - Surveys KW - Ventilation KW - Lead poisoning KW - Age KW - Asthma KW - Indicators KW - Painting KW - Communities KW - Leaks KW - Density KW - Nutrition KW - Pests KW - Air conditioning KW - Moisture KW - Data sets KW - Ecological monitoring KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743515922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Relationship+of+Housing+and+Population+Health%3A+A+30-Year+Retrospective+Analysis&rft.au=Jacobs%2C+David+E%3BWilson%2C+Jonathan%3BDixon%2C+Sherry+L%3BSmith%2C+Janet%3BEvens%2C+Anne&rft.aulast=Jacobs&rft.aufirst=David&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Structure-Activity-Dependent Regulation of Cell Communication by Perfluorinated Fatty Acids using in Vivo and in Vitro Model Systems AN - 743481476; 201004-31-0310883 (CE); 12116991 (EN) AB - BACKGROUND: Perfluoroalkanoates, [e.g., perfluorooctanoate (PFOA)], are known peroxisome proliferators that induce hepatomegaly and hepatocarcinogenesis in rodents, and are classic non-genotoxic carcinogens that inhibit in vitro gap-junctional intercellular communication (GJIC). This inhibition of GJIC is known to be a function of perfluorinated carbon lengths ranging from 7 to 10. OBJECTIVES: The aim of this study was to determine if the inhibition of GJIC by PFOA but not perfluoropentanoate (PFPeA) observed in F344 rat liver cells in vitro also occurs in F344 rats in vivo and to determine mechanisms of PFOA dysregulation of GJIC using in vitro assay systems. METHODS: We used an incision load/dye transfer technique to assess GJIC in livers of rats exposed to PFOA and PFPeA. We used in vitro assays with inhibitors of cell signaling enzymes and antioxidants known to regulate GJIC to identify which enzymes regulated PFOA-induced inhibition of GJIC. RESULTS: PFOA inhibited GJIC and induced hepatomegaly in rat livers, whereas PFPeA had no effect on either end point. Serum biochemistry of liver enzymes indicated no cytotoxic response to these compounds. In vitro analysis of mitogen-activated protein kinase (MAPK) indicated that PFOA, but not PFPeA, can activate the extracellular receptor kinase (ERK). Inhibition of GJIC, in vitro, by PFOA depended on the activation of both ERK and phosphatidylcholine-specific phospholipase C (PC-PLC) in the dysregulation of GJIC in an oxidative-dependent mechanism. CONCLUSIONS: The in vitro analysis of GJIC, an epigenetic marker of tumor promoters, can also predict the in vivo activity of PFOA, which dysregulated GJIC via ERK and PC-PLC. JF - Environmental Health Perspectives AU - Upham, Brad L AU - Park, Joon-Suk AU - Babica, Pavel AU - Sovadinova, Iva AU - Rummel, Alisa M AU - Trosko, James E AU - Hirose, Akihiko AU - Hasegawa, Ryuichi AU - Kanno, Jun AU - Sai, Kimie PY - 2009 SP - 545 EP - 551 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - In vitro testing KW - Kinases KW - Inhibition KW - Liver KW - Enzymes KW - Surgical implants KW - Biomedical materials KW - Mathematical models KW - In vivo tests KW - In vivo testing KW - Inhibitors KW - Biocompatibility KW - Health KW - Assaying KW - Rats KW - Activation KW - Carbon KW - Carcinogens KW - Fatty acids KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743481476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Structure-Activity-Dependent+Regulation+of+Cell+Communication+by+Perfluorinated+Fatty+Acids+using+in+Vivo+and+in+Vitro+Model+Systems&rft.au=Upham%2C+Brad+L%3BPark%2C+Joon-Suk%3BBabica%2C+Pavel%3BSovadinova%2C+Iva%3BRummel%2C+Alisa+M%3BTrosko%2C+James+E%3BHirose%2C+Akihiko%3BHasegawa%2C+Ryuichi%3BKanno%2C+Jun%3BSai%2C+Kimie&rft.aulast=Upham&rft.aufirst=Brad&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Arsenic Exposure within the Korean Community (United States) Based on Dietary Behavior and Arsenic Levels in Hair, Urine, Air, and Water AN - 743426841; 201004-31-0310871 (CE); 12116979 (EN) AB - BACKGROUND: Determining arsenic exposure in groups based on geographic location, dietary behaviors, or lifestyles is important, as even moderate exposures may lead to health concerns. OBJECTIVES/METHODS: The Korean community in Washington State, represents a group warranting investigation, as they consume foods (e.g., shellfish, rice, finfish, and seaweed) known to contain arsenic. As part of the Arsenic Mercury Intake Biometric Study, we examined the arsenic levels in hair and urine along with the diets of 108 women of childbearing age from within this community. Arsenic levels in indoor air and drinking water were also investigated, and shellfish commonly consumed were collected and analyzed for total and speciated arsenic. RESULTS: The six shellfish species analyzed (n = 667) contain total arsenic (range, 1-5 microg/g) but are a small source of inorganic arsenic (range, 0.01-0.12 microg/g). Six percent of the individuals may have elevated urinary inorganic arsenic levels ( 10 microg/L) due to diet. Seaweed, rice, shellfish, and finfish are principal sources for total arsenic intake/excretion based on mass balance estimates. Rice consumption (163 g/person/day) may be a significant source of inorganic arsenic. Air and water are not significant sources of exposure. Hair is a poor biometric for examining arsenic levels at low to moderate exposures. CONCLUSIONS: We conclude that a portion of this community may have dietary inorganic arsenic exposure resulting in urine levels exceeding 10 microg/L. Although their exposure is below that associated with populations exposed to high levels of arsenic from drinking water ( 100 microg/L), their exposure may be among the highest in the United States. JF - Environmental Health Perspectives AU - Cleland, Bill AU - Tsuchiya, Ami AU - Kalman, David A AU - Dills, Russell AU - Burbacher, Thomas M AU - White, Jim W AU - Faustman, Elaine M AU - Marieen, Koenraad PY - 2009 SP - 632 EP - 638 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Arsenic KW - Communities KW - Shellfish KW - Health KW - Hair KW - Urine KW - Rice KW - Drinking water KW - Consumption KW - Diets KW - Biometrics KW - Seaweeds KW - Intakes KW - Position (location) KW - Estimates KW - Indoor KW - Populations KW - Excretion KW - Mercury KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743426841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Arsenic+Exposure+within+the+Korean+Community+%28United+States%29+Based+on+Dietary+Behavior+and+Arsenic+Levels+in+Hair%2C+Urine%2C+Air%2C+and+Water&rft.au=Cleland%2C+Bill%3BTsuchiya%2C+Ami%3BKalman%2C+David+A%3BDills%2C+Russell%3BBurbacher%2C+Thomas+M%3BWhite%2C+Jim+W%3BFaustman%2C+Elaine+M%3BMarieen%2C+Koenraad&rft.aulast=Cleland&rft.aufirst=Bill&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=632&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Risk of Asthmatic Episodes in Children Exposed to Sulfur Dioxide Stack Emissions from a Refinery Point Source in Montreal, Canada AN - 743425460; 201004-31-0310868 (CE); 12116976 (EN) AB - BACKGROUND: Little is known about the respiratory effects of short-term exposures to petroleum refinery emissions in young children. This study is an extension of an ecologic study that found an increased rate of hospitalizations for respiratory conditions among children living near petroleum refineries in Montreal (Canada). METHODS: We used a time-stratified case-crossover design to assess the risk of asthma episodes in relation to short-term variations in sulfur dioxide levels among children 2-4 years of age living within 0.5-7.5 km of the refinery stacks. Health data used to measure asthma episodes included emergency department (ED) visits and hospital admissions from 1996 to 2004. We estimated daily levels of SO2 at the residence of children using a) two fixed-site SO2 monitors located near the refineries and b) the AERMOD (American Meteorological Society/Environmental Protection Agency Regulatory Model) atmospheric dispersion model. We used conditional logistic regression to estimate odds ratios associated with an increase in the interquartile range of daily SO2 mean and peak exposures (31.2 ppb for AERMOD peaks). We adjusted for temperature, relative humidity, and regional/urban background air pollutant levels. RESULTS: The risks of asthma ED visits and hospitalizations were more pronounced for same-day (lag 0) SO2 peak levels than for mean levels on the same day, or for other lags: the adjusted odds ratios estimated for same-day SO2 peak levels from AERMOD were 1.10 [95% confidence interval (CI), 1.00-1.22] and 1.42 (95% CI, 1.10-1.82), over the interquartile range, for ED visits and hospital admissions, respectively. CONCLUSIONS: Short-term episodes of increased SO2 exposures from refinery stack emissions were associated with a higher number of asthma episodes in nearby children. JF - Environmental Health Perspectives AU - Smargiassi, Audrey AU - Kosatsky, Tom AU - Hicks, John AU - Plante, Celine AU - Armstrong, Ben AU - Villeneuve, Paul J AU - Goudreau, Sophie PY - 2009 SP - 653 EP - 659 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Refineries KW - Asthma KW - Exposure KW - Risk KW - Health KW - Hospitals KW - Sulfur dioxide KW - Stack emissions KW - Adjustment KW - Relative humidity KW - Emergencies KW - Atmospherics KW - Dispersions KW - Monitors KW - Beneficiation KW - Regression KW - Point sources KW - Estimates KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743425460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Risk+of+Asthmatic+Episodes+in+Children+Exposed+to+Sulfur+Dioxide+Stack+Emissions+from+a+Refinery+Point+Source+in+Montreal%2C+Canada&rft.au=Smargiassi%2C+Audrey%3BKosatsky%2C+Tom%3BHicks%2C+John%3BPlante%2C+Celine%3BArmstrong%2C+Ben%3BVilleneuve%2C+Paul+J%3BGoudreau%2C+Sophie&rft.aulast=Smargiassi&rft.aufirst=Audrey&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Prevalence of Metabolic Syndrome Associated with Body Burden Levels of Dioxin and Related Compounds among Japan's General Population AN - 743395385; 201004-31-0310880 (CE); 12116988 (EN) AB - BACKGROUND: Environmental exposure to some persistent organic pollutants has been reported to be associated with a metabolic syndrome in the U.S. population. OBJECTIVES: We evaluated the associations of body burden levels of dioxins and related compounds with the prevalence of metabolic syndrome among the general population in Japan. METHODS: We conducted a cross-sectional study with 1,374 participants not occupationally exposed to these pollutants, living throughout Japan during 2002-2006. In fasting blood samples, we measured biochemical factors and determined lipid-adjusted concentrations of 10 polychlorinated dibenzo-p-dioxins (PCDDs), 7 polychlorinated dibenzofurans (PCDFs), and 12 dioxin-like poly-chlorinated biphenyls (DL-PCBs) all of which have toxic equivalency factors. We also performed a questionnaire survey. RESULTS: The toxic equivalents (TEQs) of PCDDs, PCDFs, and DL-PCBs and total TEQs had significant adjusted associations with metabolic syndrome, whether or not we excluded diabetic subjects. By analyzing each component of metabolic syndrome separately, the DL-PCB TEQs and total TEQs were associated with all components, and the odds ratios (ORs) in the highest quartile of DL-PCB TEQs in four of the five components were higher than those for PCDDs or PCDFs. We also found congener-specific associations with metabolic syndrome; in particular, the highest quartiles of PCB-126 and PCB-105 had adjusted ORs of 9.1 and 7.3, respectively. CONCLUSIONS: These results suggest that body burden levels of dioxins and related compounds, particularly those of DL-PCBs, are associated with metabolic syndrome. Of the components, high blood pressure, elevated triglycerides, and glucose intolerance were most closely associated with these pollutants. JF - Environmental Health Perspectives AU - Uemura, Hirokazu AU - Arisawa, Kokichi AU - Hiyoshi, Mineyoshi AU - Kitayama, Atsushi AU - Takami, Hidenobu AU - Sawachika, Fusakazu AU - Dakeshita, Satoru AU - Nii, Kentaro AU - Satoh, Hiroshi AU - Sumiyoshi, Yoshio AU - Morinaga, Kenji AU - Kodama, Kazunori AU - Suzuki, Taka-ichiro AU - Nagai, Masaki AU - Suzuki, Tsuguyoshi PY - 2009 SP - 568 EP - 573 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Pollutants KW - Dioxins KW - Toxic KW - Health KW - Quartiles KW - Adjustment KW - Equivalence KW - Toxicology KW - High blood pressure KW - Fasting KW - Elevated KW - Glucose KW - Copyrights KW - Biochemistry KW - Triglycerides KW - Blood KW - Exposure KW - Cross sections KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743395385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prevalence+of+Metabolic+Syndrome+Associated+with+Body+Burden+Levels+of+Dioxin+and+Related+Compounds+among+Japan%27s+General+Population&rft.au=Uemura%2C+Hirokazu%3BArisawa%2C+Kokichi%3BHiyoshi%2C+Mineyoshi%3BKitayama%2C+Atsushi%3BTakami%2C+Hidenobu%3BSawachika%2C+Fusakazu%3BDakeshita%2C+Satoru%3BNii%2C+Kentaro%3BSatoh%2C+Hiroshi%3BSumiyoshi%2C+Yoshio%3BMorinaga%2C+Kenji%3BKodama%2C+Kazunori%3BSuzuki%2C+Taka-ichiro%3BNagai%2C+Masaki%3BSuzuki%2C+Tsuguyoshi&rft.aulast=Uemura&rft.aufirst=Hirokazu&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Preparing for Climate Change: A Perspective from Local Public Health Officers in California AN - 743391529; 201004-31-0310873 (CE); 12116981 (EN) AB - BACKGROUND: The most recent scientific findings show that even with significant emission reductions, some amount of climate change is likely inevitable. The magnitude of the climate changes will depend on future emissions and climate sensitivity. These changes will have local impacts, and a significant share of coping with these changes will fall on local governmental agencies. Public health is no exception, because local public health agencies are crucial providers of disease prevention, health care, and emergency preparedness services. METHODS: This article presents the results of a survey of California's local pubic health officers conducted between August and October 2007. The survey gauged health officers' concerns about the public health impacts of climate change, programs in place that could help to mitigate these health effects, and information and resource needs for better coping with a changing climate. RESULTS: The results of this survey show that most public health officers feel that climate change poses a serious threat to public health but that they do not feel well equipped in terms of either resources or information to cope with that threat. Nonetheless, public health agencies currently implement a number of programs that will help these agencies handle some of the challenges posed by a changing climate. CONCLUSIONS: Overall, the results suggest that local public health agencies in California are likely in a better position than they perceive to address the threats associated with climate change but that there is a larger role for them to play in climate policy. JF - Environmental Health Perspectives AU - Bedsworth, Louise PY - 2009 SP - 617 EP - 623 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Public health KW - Climate KW - Climate change KW - Health KW - Emergencies KW - Copyrights KW - Health care KW - Handles KW - Emissions control KW - Policies KW - Government agencies KW - Reduction KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743391529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Preparing+for+Climate+Change%3A+A+Perspective+from+Local+Public+Health+Officers+in+California&rft.au=Bedsworth%2C+Louise&rft.aulast=Bedsworth&rft.aufirst=Louise&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Predicting Chronic Fine and Coarse Particulate Exposures Using Spatiotemporal Models for the Northeastern and Midwestern United States AN - 743389203; 201004-31-0310886 (CE); 12116994 (EN) AB - BACKGROUND: Chronic epidemiologic studies of particulate matter (PM) are limited by the lack of monitoring data, relying instead on citywide ambient concentrations to estimate exposures. This method ignores within-city spatial gradients and restricts studies to areas with nearby monitoring data. This lack of data is particularly restrictive for fine particles (PM with aerodynamic diameter 2.5 microm; PM(2.5)) and coarse particles (PM with aerodynamic diameter 2.5-10 microm; PM(10-2.5)), for which monitoring is limited before 1999. To address these limitations, we developed spatiotemporal models to predict monthly outdoor PM(2.5) and PM(10-2.5) concentrations for the northeastern and midwestern United States. METHODS: For PM(2.5), we developed models for two periods: 1988-1998 and 1999-2002. Both models included smooth spatial and regression terms of geographic information system-based and meteorologic predictors. To compensate for sparse monitoring data, the pre-1999 model also included predicted PM(10) (PM with aerodynamic diameter 10 microm) and extinction coefficients (km(-1)). PM(10-2.5) levels were estimated as the difference in monthly predicted PM(10) and PM(2.5), with predicted PM(10) from our previously developed PM(10) model. RESULTS: Predictive performance for PM(2.5) was strong (cross-validation R2 = 0.77 and 0.69 for post-1999 and pre-1999 PM(2.5) models, respectively) with high precision (2.2 and 2.7 microg/m3, respectively). Models performed well irrespective of population density and season. Predictive performance for PM(10-2.5) was weaker (cross-validation R2 = 0.39) with lower precision (5.5 microg/m3). PM(10-2.5) levels exhibited greater local spatial variability than PM(10) or PM(2.5), suggesting that PM(2.5) measurements at ambient monitoring sites are more representative for surrounding populations than for PM(10) and especially PM(10-2.5). CONCLUSIONS: We provide semiempirical models to predict spatially and temporally resolved long-term average outdoor concentrations of PM(2.5) and PM(10-2.5) for estimating exposures of populations living in the northeastern and midwestern United States. JF - Environmental Health Perspectives AU - Yanosky, Jeff D AU - Paciorek, Christopher J AU - Suh, Helen H PY - 2009 SP - 522 EP - 529 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Monitoring KW - Exposure KW - Aerodynamics KW - Outdoor KW - Health KW - Population density KW - Regression KW - Copyrights KW - Seasons KW - Estimates KW - Extinction KW - Epidemiology KW - Coarsening KW - Estimating KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743389203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Predicting+Chronic+Fine+and+Coarse+Particulate+Exposures+Using+Spatiotemporal+Models+for+the+Northeastern+and+Midwestern+United+States&rft.au=Yanosky%2C+Jeff+D%3BPaciorek%2C+Christopher+J%3BSuh%2C+Helen+H&rft.aulast=Yanosky&rft.aufirst=Jeff&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Predicting Plasma Concentrations of Bisphenol A in Children Younger Than 2 Years of Age after Typical Feeding Schedules, using a Physiologically Based Toxicokinetic Model AN - 743386129; 201004-31-0310869 (CE); 12116977 (EN) AB - BACKGROUND: Concerns have recently been raised regarding the safety of potential human exposure to bisphenol A (BPA), an industrial chemical found in some polycarbonate plastics and epoxy resins. Of particular interest is the exposure of young children to BPA via food stored in BPA-containing packaging. OBJECTIVES: In this study we assessed the age dependence of the toxicokinetics of BPA and its glucuronidated metabolite, BPA-Glu, using a coupled BPA-BPA-Glu physiologically based toxicokinetic (PBTK) model. METHODS: Using information gathered from toxicokinetic studies in adults, we built a PBTK model. We then scaled the model to children 2 years of age based on the age dependence of physiologic parameters relevant for absorption, distribution, metabolism, and excretion. RESULTS: We estimated the average steady-state BPA plasma concentration in newborns to be 11 times greater than that in adults when given the same weight-normalized dose. Because of the rapid development of the glucuronidation process, this ratio dropped to 2 by 3 months of age. Simulation of typical feeding exposures, as estimated by regulatory authorities, showed a 5-fold greater steady-state BPA plasma concentration in 3- and 6-month-olds compared with adults, reflecting both a reduced capacity for BPA metabolism and a greater weight-normalized BPA exposure. Because of uncertainty in defining the hepatic BPA intrinsic clearance in adults, these values represent preliminary estimates. CONCLUSIONS: Simulations of the differential BPA dosimetry between adults and young children point to the need for more sensitive analytical methods for BPA to define, with greater certainty, the adult hepatic BPA intrinsic clearance, as well as a need for external exposure data in young children. JF - Environmental Health Perspectives AU - Edginton, Andrea N AU - Ritter, Len PY - 2009 SP - 645 EP - 652 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Adults KW - Children KW - Age KW - Bisphenol A KW - Health KW - Clearances KW - Metabolism KW - Simulation KW - Feeding KW - Rapids KW - Estimates KW - Metabolites KW - Schedules KW - Excretion KW - Mathematical analysis KW - Dosimeters KW - Copyrights KW - Packaging KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743386129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Predicting+Plasma+Concentrations+of+Bisphenol+A+in+Children+Younger+Than+2+Years+of+Age+after+Typical+Feeding+Schedules%2C+using+a+Physiologically+Based+Toxicokinetic+Model&rft.au=Edginton%2C+Andrea+N%3BRitter%2C+Len&rft.aulast=Edginton&rft.aufirst=Andrea&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=645&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - PAH-DNA Adducts, Cigarette Smoking, GST Polymorphisms, and Breast Cancer Risk AN - 743370973; 201004-31-0310882 (CE); 12116990 (EN) AB - BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) may increase breast cancer risk, and the association may be modified by inherited differences in deactivation of PAH intermediates by glutathione S-transferases (GSTs). Few breast cancer studies have investigated the joint effects of multiple GSTs and a PAH biomarker. OBJECTIVE: We estimated the breast cancer risk associated with multiple polymorphisms in the GST gene (GSTA1, GSTM1, GSTP1, and GSTT1) and the interaction with PAH-DNA adducts and cigarette smoking. METHODS: We conducted unconditional logistic regression using data from a population-based sample of women (cases/controls, respectively): GST polymorphisms were genotyped using polymerase chain reaction and matrix-assisted laser desorption/ionization time-of-flight assays (n = 926 of 916), PAH-DNA adduct blood levels were measured by competitive enzyme-linked immunosorbent assay (n = 873 of 941), and smoking status was assessed by in-person questionnaires (n = 943 of 973). RESULTS: Odds ratios for joint effects on breast cancer risk among women with at least three variant alleles were 1.56 [95% confidence interval (CI), 1.13-2.16] for detectable PAH-DNA adducts and 0.93 (95% CI, 0.56-1.56) for no detectable adducts; corresponding odds ratios for three or more variants were 1.18 (95% CI, 0.82-1.69) for ever smokers and 1.44 (95% CI, 0.97-2.14) for never smokers. Neither interaction was statistically significant (p = 0.43 and 0.62, respectively). CONCLUSION: We found little statistical evidence that PAHs interacted with GSTT1, GSTM1, GSTP1, and GSTA1 polymorphisms to further increase breast cancer risk. JF - Environmental Health Perspectives AU - McCarty, Kathleen M AU - Santella, Regina M AU - Steck, Susan E AU - Cleveland, Rebecca J AU - Ahn, Jiyoung AU - Ambrosone, Christine B AU - North, Kari AU - Sagiv, Sharon K AU - Eng, Sybil M AU - Teitelbaum, Susan L AU - Neugut, Alfred I AU - Gammon, Marilie D PY - 2009 SP - 552 EP - 558 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Breast KW - Cancer KW - Risk KW - Adducts KW - Polyallylamine hydrochloride KW - Polymorphism KW - Smoking KW - Cigarettes KW - Health KW - Assaying KW - Ionization KW - Statistical methods KW - Samples KW - Regression KW - Statistical analysis KW - Glutathione KW - Lasers KW - Polymerase chain reaction KW - Confidence intervals KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743370973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=PAH-DNA+Adducts%2C+Cigarette+Smoking%2C+GST+Polymorphisms%2C+and+Breast+Cancer+Risk&rft.au=McCarty%2C+Kathleen+M%3BSantella%2C+Regina+M%3BSteck%2C+Susan+E%3BCleveland%2C+Rebecca+J%3BAhn%2C+Jiyoung%3BAmbrosone%2C+Christine+B%3BNorth%2C+Kari%3BSagiv%2C+Sharon+K%3BEng%2C+Sybil+M%3BTeitelbaum%2C+Susan+L%3BNeugut%2C+Alfred+I%3BGammon%2C+Marilie+D&rft.aulast=McCarty&rft.aufirst=Kathleen&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=552&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A New Spin on Research Translation: The Boston Consensus Conference on Human Biomonitoring AN - 743362095; 201004-31-0310890 (CE); 12116998 (EN) AB - BACKGROUND: Translating research to make it more understandable and effective (research translation) has been declared a priority in environmental health but does not always include communication to the public or residents of communities affected by environmental hazards. Their unique perspectives are also commonly missing from discussions about science and technology policy. The consensus conference process, developed in Denmark, offers a way to address this gap. OBJECTIVES: The Boston Consensus Conference on Human Biomonitoring, held in Boston, Massachusetts, in the fall of 2006, was designed to educate and elicit input from 15 Boston-area residents on the scientifically complex topic of human biomonitoring for environmental chemicals. This lay panel considered the many ethical, legal, and scientific issues surrounding biomonitoring and prepared a report expressing their views. DISCUSSION: The lay panel's findings provide a distinct and important voice on the expanding use of biomonitoring. In some cases, such as a call for opt-in reporting of biomonitoring results to study participants, they mirror recommendations raised elsewhere. Other conclusions have not been heard previously, including the recommendation that an individual's results should be statutorily exempted from the medical record unless permission is granted, and the opportunity to use biomonitoring data to stimulate green chemistry. CONCLUSION: The consensus conference model addresses both aspects of a broader conception of research translation: engaging the public in scientific questions, and bringing their unique perspectives to bear on public health research, practice, and policy. In this specific application, a lay panel's recommendations on biomonitoring surveillance, communication, and ethics have practical implications for the conduct of biomonitoring studies and surveillance programs. JF - Environmental Health Perspectives AU - Nelson, Jessica W AU - Scammell, Madeleine Kangsen AU - Altman, Rebecca Gasior AU - Webster, Thomas F AU - Ozonoff, David M PY - 2009 SP - 495 EP - 499 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Conferences KW - Panels KW - Health KW - Human KW - Translations KW - Policies KW - Ethics KW - Surveillance KW - Medical KW - Reporting KW - Voice KW - Cases KW - Education KW - Translating KW - Priorities KW - Communities KW - Hazards KW - Legal KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743362095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+New+Spin+on+Research+Translation%3A+The+Boston+Consensus+Conference+on+Human+Biomonitoring&rft.au=Nelson%2C+Jessica+W%3BScammell%2C+Madeleine+Kangsen%3BAltman%2C+Rebecca+Gasior%3BWebster%2C+Thomas+F%3BOzonoff%2C+David+M&rft.aulast=Nelson&rft.aufirst=Jessica&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Impacts of Climate Change on Indirect Human Exposure to Pathogens and Chemicals from Agriculture AN - 743297766; 201004-31-0310888 (CE); 12116996 (EN) AB - OBJECTIVE: Climate change is likely to affect the nature of pathogens and chemicals in the environment and their fate and transport. Future risks of pathogens and chemicals could therefore be very different from those of today. In this review, we assess the implications of climate change for changes in human exposures to pathogens and chemicals in agricultural systems in the United Kingdom and discuss the subsequent effects on health impacts. DATA SOURCES: In this review, we used expert input and considered literature on climate change; health effects resulting from exposure to pathogens and chemicals arising from agriculture; inputs of chemicals and pathogens to agricultural systems; and human exposure pathways for pathogens and chemicals in agricultural systems. DATA SYNTHESIS: We established the current evidence base for health effects of chemicals and pathogens in the agricultural environment; determined the potential implications of climate change on chemical and pathogen inputs in agricultural systems; and explored the effects of climate change on environmental transport and fate of different contaminant types. We combined these data to assess the implications of climate change in terms of indirect human exposure to pathogens and chemicals in agricultural systems. We then developed recommendations on future research and policy changes to manage any adverse increases in risks. CONCLUSIONS: Overall, climate change is likely to increase human exposures to agricultural contaminants. The magnitude of the increases will be highly dependent on the contaminant type. Risks from many pathogens and particulate and particle-associated contaminants could increase significantly. These increases in exposure can, however, be managed for the most part through targeted research and policy changes. JF - Environmental Health Perspectives AU - Boxall, Alistair B A AU - Hardy, Anthony AU - Beulke, Sabine AU - Boucard, Tatiana AU - Burgin, Laura AU - Falloon, Peter D AU - Haygarth, Philip M AU - Hutchinson, Thomas AU - Kovats, R Sari AU - Leonardi, Giovanni AU - Levy, Leonard S AU - Nichols, Gordon AU - Parsons, Simon A AU - Potts, Laura AU - Stone, David AU - Topp, Edward AU - Turley, David B AU - Walsh, Kerry AU - Wellington, Elizabeth M H PY - 2009 SP - 508 EP - 514 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Pathogens KW - Climate change KW - Agricultural chemicals KW - Human KW - Health KW - Contaminants KW - Risk KW - Transport KW - Policies KW - Agricultural management KW - Agriculture KW - Copyrights KW - Synthesis KW - Data sources KW - Pathways KW - Stone KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743297766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Impacts+of+Climate+Change+on+Indirect+Human+Exposure+to+Pathogens+and+Chemicals+from+Agriculture&rft.au=Boxall%2C+Alistair+B+A%3BHardy%2C+Anthony%3BBeulke%2C+Sabine%3BBoucard%2C+Tatiana%3BBurgin%2C+Laura%3BFalloon%2C+Peter+D%3BHaygarth%2C+Philip+M%3BHutchinson%2C+Thomas%3BKovats%2C+R+Sari%3BLeonardi%2C+Giovanni%3BLevy%2C+Leonard+S%3BNichols%2C+Gordon%3BParsons%2C+Simon+A%3BPotts%2C+Laura%3BStone%2C+David%3BTopp%2C+Edward%3BTurley%2C+David+B%3BWalsh%2C+Kerry%3BWellington%2C+Elizabeth+M+H&rft.aulast=Boxall&rft.aufirst=Alistair+B&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Direct Effects, Compensation, and Recovery in Female Fathead Minnows Exposed to a Model Aromatase Inhibitor AN - 743175130; 201004-31-0310872 (CE); 12116980 (EN) AB - BACKGROUND: Several chemicals in the environment have the potential to inhibit aromatase, an enzyme critical to estrogen synthesis. OBJECTIVES: The objective of this study was to provide a detailed characterization of molecular and biochemical responses of female fathead minnows to a model aromatase inhibitor, fadrozole (FAD). METHODS: Fish were exposed via water to 0, 3, or 30 microg FAD/L for 8 days and then held in clean water for 8 days, with samples collected at four time points during each 8-day period. We quantified ex vivo steroid production, plasma steroids, and plasma vitellogenin (Vtg) concentrations and analyzed relative transcript abundance of 10 key regulatory genes in ovaries and 3 in pituitary tissue by real-time polymerase chain reaction. RESULTS: Ex vivo 17beta-estradiol (E2) production and plasma E2 and Vtg concentrations were significantly reduced after a single day of exposure to 3 microg or 30 microg FAD/L. However, plasma E2 concentrations recovered by the eighth day of exposure in the 3-microg/L group and within 1 day of cessation of exposure in the 30-microg/L group, indicating concentration- and time-dependent physiologic compensation and recovery. Concentration-dependent increases in transcripts coding for aromatase (A isoform), cytochrome P450 side-chain cleavage, steroidogenic acute regulatory protein, and follicle-stimulating hormone receptor all coincided with increased E2 production and recovery of plasma E2 concentrations. CONCLUSIONS: Results of this research highlight the need to consider compensation/adaptation and recovery when developing and interpreting short-term bioassays or biomarkers or when trying to predict the effects of chemical exposures based on mode of action. JF - Environmental Health Perspectives AU - Villeneuve, Daniel L AU - Mueller, Nathaniel D AU - Martinovic, Dalma AU - Makynen, Elizabeth A AU - Kahl, Michael D AU - Jensen, Kathleen M AU - Durhan, Elizabeth J AU - Cavallin, Jenna E AU - Bencic, David AU - Ankley, Gerald T PY - 2009 SP - 624 EP - 631 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Inhibitors KW - Recovery KW - Compensation KW - Health KW - Mathematical models KW - Females KW - Steroids KW - Exposure KW - Enzymes KW - Coding KW - Bioassay KW - Cytochromes P450 KW - Estrogens KW - Hormones KW - Cleaning KW - Polymerase chain reaction KW - Fish KW - Receptors KW - Synthesis KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743175130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Direct+Effects%2C+Compensation%2C+and+Recovery+in+Female+Fathead+Minnows+Exposed+to+a+Model+Aromatase+Inhibitor&rft.au=Villeneuve%2C+Daniel+L%3BMueller%2C+Nathaniel+D%3BMartinovic%2C+Dalma%3BMakynen%2C+Elizabeth+A%3BKahl%2C+Michael+D%3BJensen%2C+Kathleen+M%3BDurhan%2C+Elizabeth+J%3BCavallin%2C+Jenna+E%3BBencic%2C+David%3BAnkley%2C+Gerald+T&rft.aulast=Villeneuve&rft.aufirst=Daniel&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=624&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Direct Impairment of Vascular Function by Diesel Exhaust Particulate through Reduced Bioavailability of Endothelium-Derived Nitric Oxide Induced by Superoxide Free Radicals AN - 743172509; 201004-31-0310874 (CE); 12116982 (EN) AB - BACKGROUND: Diesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects of air pollution. OBJECTIVES: We assessed the in vitro effects of DEP on vascular function, nitric oxide (NO) availability, and the generation of oxygen-centered free radicals. METHODS: We assessed the direct vascular effects of DEP (10-100 microg/mL) in isolated rat aortic rings using myography. We investigated NO scavenging and oxygen-centered free radical generation using an NO electrode and electron paramagnetic resonance (EPR) with the Tempone-H (1-hydroxyl-2,2,6,6-tetramethyl-4-oxo-piperidine) spin trap, respectively. RESULTS: Acetylcholine-induced relaxation was attenuated by DEP (maximum relaxation reduced from 91 +/- 4% to 49 +/- 6% with 100 microg/mL DEP; p 0.001) but was restored by superoxide dismutase (SOD; maximum relaxation, 73 +/- 6%; p 0.001). DEP caused a modest inhibition of relaxation to NO donor drugs, an effect that could be reversed by SOD (p 0.01). At 10 microg/mL, DEP did not affect verapamil-induced relaxation (p = 0.73), but at 100 microg/mL DEP inhibited relaxation (p 0.001) by a mechanism independent of SOD. NO concentrations generated by 2-(N,N-diethylamino)-diazenolate-2-oxide (DEA/NO; 10 microM) were reduced by DEP (100 microg/mL; from 5.2 +/- 0.4 to 3.3 +/- 0.4 microM; p = 0.002). Free radical generation was increased by DEP (10 microg/mL; 9-fold increase in EPR spectra; p = 0.004) in a manner that could be attenuated by SOD (p = 0.015). CONCLUSIONS: DEP caused oxidative stress through the generation of oxygen-centered free radicals that reduced the bioavailability of endothelium-derived NO without prior interaction with the lung or vascular tissue. These findings provide a mechanism for the adverse cardiovascular effects of particulate air pollution. JF - Environmental Health Perspectives AU - Miller, Mark R AU - Borthwick, Stephen J AU - Shaw, Catherine A AU - McLean, Steven G AU - McClure, Daniel AU - Mills, Nicholas L AU - Duffin, Rodger AU - Donaldson, Ken AU - Megson, Ian L AU - Hadoke, Patrick W F AU - Newby, David E PY - 2009 SP - 611 EP - 616 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Free radicals KW - Sod KW - Air pollution KW - Bioavailability KW - Diesel KW - Diesel fuels KW - In vitro testing KW - Health KW - Exhaust KW - Attenuation KW - Nitric oxide KW - Electrodes KW - Electron paramagnetic resonance KW - Vascular tissue KW - Mills KW - Impairment KW - Drugs KW - Scavenging KW - Spectra KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743172509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Direct+Impairment+of+Vascular+Function+by+Diesel+Exhaust+Particulate+through+Reduced+Bioavailability+of+Endothelium-Derived+Nitric+Oxide+Induced+by+Superoxide+Free+Radicals&rft.au=Miller%2C+Mark+R%3BBorthwick%2C+Stephen+J%3BShaw%2C+Catherine+A%3BMcLean%2C+Steven+G%3BMcClure%2C+Daniel%3BMills%2C+Nicholas+L%3BDuffin%2C+Rodger%3BDonaldson%2C+Ken%3BMegson%2C+Ian+L%3BHadoke%2C+Patrick+W+F%3BNewby%2C+David+E&rft.aulast=Miller&rft.aufirst=Mark&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Acute Effects of Air Pollution on Pulmonary Function, Airway Inflammation, and Oxidative Stress in Asthmatic Children AN - 743154415; 201004-31-0310866 (CE); 12116974 (EN) AB - BACKGROUND: Air pollution is associated with respiratory symptoms, lung function decrements, and hospitalizations. However, there is little information about the influence of air pollution on lung injury. OBJECTIVE: In this study we investigated acute effects of air pollution on pulmonary function and airway oxidative stress and inflammation in asthmatic children. METHODS: We studied 182 children with asthma, 9-14 years of age, for 4 weeks. Daily ambient concentrations of sulfur dioxide, nitrogen dioxide, ozone, and particulate matter or = 2.5 microm in aerodynamic diameter (PM(2.5)) were monitored from two stations. Once a week we measured spirometry and fractional exhaled nitric oxide (FeNO), and determined thiobarbituric acid reactive substances (TBARS) and 8-isoprostane--two oxidative stress markers--and interleukin-6 (IL-6) in breath condensate. We tested associations using mixed-effects regression models, adjusting for confounding variables. RESULTS: Interquartile-range increases in 3-day average SO2 (5.4 ppb), NO2 (6.8 ppb), and PM(2.5) (5.4 microg/m3) were associated with decreases in forced expiratory flow between 25% and 75% of forced vital capacity, with changes being -3.1% [95% confidence interval (CI), -5.8 to -0.3], -2.8% (95% CI, -4.8 to -0.8), and -3.0% (95% CI, -4.7 to -1.2), respectively. SO2, NO2, and PM(2.5) were associated with increases in TBARS, with changes being 36.2% (95% CI, 15.7 to 57.2), 21.8% (95% CI, 8.2 to 36.0), and 24.8% (95% CI, 10.8 to 39.4), respectively. Risk estimates appear to be larger in children not taking corticosteroids than in children taking corticosteroids. O3 (5.3 ppb) was not associated with health end points. FeNO, 8-isoprostane, and IL-6 were not associated with air pollutants. CONCLUSION: Air pollution may increase airway oxidative stress and decrease small airway function of asthmatic children. Inhaled corticosteroids may reduce oxidative stress and improve airway function. JF - Environmental Health Perspectives AU - Liu, Ling AU - Poon, Raymond AU - Chen, Li AU - Frescura, Anna-Maria AU - Montuschi, Paolo AU - Ciabattoni, Giovanni AU - Wheeler, Amanda AU - Dales, Robert PY - 2009 SP - 668 EP - 674 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Children KW - Air pollution KW - Stresses KW - Airways KW - Nitrogen dioxide KW - Health KW - Corticosteroids KW - Lungs KW - Pulmonary functions KW - Asthma KW - Risk KW - Regression KW - Estimates KW - Stations KW - Confidence intervals KW - Condensates KW - Injuries KW - Stress concentration KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743154415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Acute+Effects+of+Air+Pollution+on+Pulmonary+Function%2C+Airway+Inflammation%2C+and+Oxidative+Stress+in+Asthmatic+Children&rft.au=Liu%2C+Ling%3BPoon%2C+Raymond%3BChen%2C+Li%3BFrescura%2C+Anna-Maria%3BMontuschi%2C+Paolo%3BCiabattoni%2C+Giovanni%3BWheeler%2C+Amanda%3BDales%2C+Robert&rft.aulast=Liu&rft.aufirst=Ling&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=668&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Correlations between Prenatal Exposure to Perfluorinated Chemicals and Reduced Fetal Growth AN - 743149551; 201004-31-0310867 (CE); 12116975 (EN) AB - BACKGROUND: Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are man-made, ubiquitous, and persistent contaminants in the environment, wildlife, and humans. Although recent studies have shown that these chemicals interfere with fetal growth in humans, the results are inconsistent. OBJECTIVES: Our goal was to investigate the correlation between relatively low levels of PFOS and PFOA in maternal serum and birth weight and birth size. METHODS: We conducted a hospital-based prospective cohort study between July 2002 and October 2005 in Sapporo, Japan. A total of 428 women and their infants were involved in the study. We obtained characteristics of the mothers and infants from self-administered questionnaire surveys and from medical records. We analyzed maternal serum samples for PFOS and PFOA by liquid chromatography-tandem mass spectrometry (LC/MS/MS). RESULTS: After adjusting for confounding factors, PFOS levels negatively correlated with birth weight [per log10 unit: beta = -148.8 g; 95% confidence interval (CI), -297.0 to -0.5 g]. In addition, analyses stratified by sex revealed that PFOS levels negatively correlated with birth weight only in female infants (per log10 unit: beta = -269.4 g; 95% CI, -465.7 to -73.0 g). However, we observed no correlation between PFOA levels and birth weight. CONCLUSION: Our results indicate that in utero exposure to relatively low levels of PFOS was negatively correlated with birth weight. JF - Environmental Health Perspectives AU - Washino, Noriaki AU - Saijo, Yasuaki AU - Sasaki, Seiko AU - Kato, Shizue AU - Ban, Susumu AU - Konishi, Kanae AU - Ito, Rie AU - Nakata, Ayako AU - Iwasaki, Yusuke AU - Saito, Koichi AU - Nakazawa, Hiroyuki AU - Kishi, Reiko PY - 2009 SP - 660 EP - 667 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Birth KW - Correlation KW - Infants KW - Beta KW - Health KW - Low level KW - Serums KW - Human KW - Sulfonates KW - Medical KW - Contaminants KW - Liquids KW - Mass spectrometry KW - Confidence intervals KW - Correlation analysis KW - Surveys KW - Chromatography KW - Copyrights KW - Females KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743149551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Correlations+between+Prenatal+Exposure+to+Perfluorinated+Chemicals+and+Reduced+Fetal+Growth&rft.au=Washino%2C+Noriaki%3BSaijo%2C+Yasuaki%3BSasaki%2C+Seiko%3BKato%2C+Shizue%3BBan%2C+Susumu%3BKonishi%2C+Kanae%3BIto%2C+Rie%3BNakata%2C+Ayako%3BIwasaki%2C+Yusuke%3BSaito%2C+Koichi%3BNakazawa%2C+Hiroyuki%3BKishi%2C+Reiko&rft.aulast=Washino&rft.aufirst=Noriaki&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=660&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Cancer Incidence among Pesticide Applicators Exposed to Permethrin in the Agricultural Health Study AN - 743135347; 201004-31-0310878 (CE); 12116986 (EN) AB - BACKGROUND: Permethrin is a synthetic pyrethroid insecticide widely used in agriculture, in public health, and in many U.S. homes and gardens. OBJECTIVE: In this study we evaluated the incidence of cancer among pesticide applicators exposed to permethrin in the Agricultural Health Study (AHS). METHODS: A total of 49,093 pesticide applicators were included in this analysis of the AHS, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered questionnaires completed in 1993-1997. Average length of follow-up since applicator enrollment in the cohort was 9.14 years. We used two permethrin exposure metrics: a) lifetime days applicators personally mixed or applied permethrin and b) intensity-weighted lifetime days (lifetime days weighted by estimated intensity of exposure). We used Poisson regression analysis to estimate relative risks (RRs) and 95% confidence intervals (CIs) for malignancies by tertiles of exposure. RESULTS: We found no associations between permethrin and all malignant neoplasms combined, or between permethrin and melanoma, non-Hodgkin lymphoma, leukemia, or cancers of the colon, rectum, lung, or prostate. We found elevated and statistically significant risks for multiple myeloma in the highest tertiles of both lifetime exposure-days (RR = 5.72; 95% CI, 2.76-11.87) and intensity-weighted lifetime exposure-days (RR = 5.01; 95% CI, 2.41-10.42), compared with applicators reporting they never used permethrin; these results are based on only 15 exposed cases. These findings were similar across a variety of alternative exposure metrics, exposure categories, and reference groups. CONCLUSIONS: This study found no association with most cancers analyzed. Although the suggested association with multiple myeloma was based on a small number of cases, it warrants further evaluation. JF - Environmental Health Perspectives AU - Rusiecki, Jennifer A AU - Patel, Rahulkumar AU - Koutros, Stella AU - Beane-Freeman, Laura AU - Landgren, Ola AU - Bonner, Matthew R AU - Coble, Joseph AU - Lubin, Jay AU - Blair, Aaron AU - Hoppin, Jane A AU - Alavanja, Michael C R PY - 2009 SP - 581 EP - 586 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Pesticides KW - Exposure KW - Health KW - Cancer KW - Risk KW - Agricultural chemicals KW - Incidence KW - Categories KW - Colon KW - Insecticides KW - Reporting KW - Leukemias KW - Estimates KW - Regression analysis KW - Neoplasms KW - Prostate KW - Confidence intervals KW - Elevated KW - Agriculture KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743135347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Cancer+Incidence+among+Pesticide+Applicators+Exposed+to+Permethrin+in+the+Agricultural+Health+Study&rft.au=Rusiecki%2C+Jennifer+A%3BPatel%2C+Rahulkumar%3BKoutros%2C+Stella%3BBeane-Freeman%2C+Laura%3BLandgren%2C+Ola%3BBonner%2C+Matthew+R%3BCoble%2C+Joseph%3BLubin%2C+Jay%3BBlair%2C+Aaron%3BHoppin%2C+Jane+A%3BAlavanja%2C+Michael+C+R&rft.aulast=Rusiecki&rft.aufirst=Jennifer&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Cumulative Exposure to Lead in Relation to Cognitive Function in Older Women AN - 743128505; 201004-31-0310879 (CE); 12116987 (EN) AB - BACKGROUND: Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women. OBJECTIVE: We examined biomarkers of lead exposure in relation to performance on a battery of cognitive tests among older women. METHODS: Patella and tibia bone lead--measures of cumulative exposure over many years--and blood lead, a measure of recent exposure, were assessed in 587 women 47-74 years of age. We assessed their cognitive function 5 years later using validated telephone interviews. RESULTS: Mean +/- SD lead levels in tibia, patella, and blood were 10.5 +/- 9.7 microg/g bone, 12.6 +/- 11.6 microg/g bone, and 2.9 +/- 1.9 microg/dL, respectively, consistent with community-level exposures. In multivariable-adjusted analyses of all cognitive tests combined, levels of all three lead biomarkers were associated with worse cognitive performance. The association between bone lead and letter fluency score differed dramatically from the other bone lead-cognitive score associations, and exclusion of this particular score from the combined analyses strengthened the associations between bone lead and cognitive performance. Results were statistically significant only for tibia lead: one SD increase in tibia lead corresponded to a 0.051-unit lower standardized summary cognitive score (95% confidence interval: -0.099 to -0.003; p = 0.04), similar to the difference in cognitive scores we observed between women who were 3 years apart in age. CONCLUSIONS: These findings suggest that cumulative exposure to lead, even at low levels experienced in community settings, may have adverse consequences for women's cognition in older age. JF - Environmental Health Perspectives AU - Weuve, Jennifer AU - Korrick, Susan A AU - Weisskopf, Marc A AU - Ryan, Louise M AU - Schwartz, Joel AU - Nie, Huiling AU - Grodstein, Francine AU - Hu, Howard PY - 2009 SP - 574 EP - 580 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Bones KW - Tibia KW - Age KW - Blood KW - Patella KW - Cognition KW - Health KW - Confidence intervals KW - Communities KW - Battery KW - Copyrights KW - Low level KW - Telephones KW - Electric batteries KW - Summaries KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743128505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Cumulative+Exposure+to+Lead+in+Relation+to+Cognitive+Function+in+Older+Women&rft.au=Weuve%2C+Jennifer%3BKorrick%2C+Susan+A%3BWeisskopf%2C+Marc+A%3BRyan%2C+Louise+M%3BSchwartz%2C+Joel%3BNie%2C+Huiling%3BGrodstein%2C+Francine%3BHu%2C+Howard&rft.aulast=Weuve&rft.aufirst=Jennifer&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Childhood Asthma and Environmental Exposures at Swimming Pools: State of the Science and Research Recommendations AN - 743115182; 201004-31-0310889 (CE); 12116997 (EN) AB - OBJECTIVES: Recent studies have explored the potential for swimming pool disinfection by-products (DBPs), which are respiratory irritants, to cause asthma in young children. Here we describe the state of the science on methods for understanding children's exposure to DBPs and biologics at swimming pools and associations with new-onset childhood asthma and recommend a research agenda to improve our understanding of this issue. DATA SOURCES: A workshop was held in Leuven, Belgium, 21-23 August 2007, to evaluate the literature and to develop a research agenda to better understand children's exposures in the swimming pool environment and their potential associations with new-onset asthma. Participants, including clinicians, epidemiologists, exposure scientists, pool operations experts, and chemists, reviewed the literature, prepared background summaries, and held extensive discussions on the relevant published studies, knowledge of asthma characterization and exposures at swimming pools, and epidemiologic study designs. SYNTHESIS: Childhood swimming and new-onset childhood asthma have clear implications for public health. If attendance at indoor pools increases risk of childhood asthma, then concerns are warranted and action is necessary. If there is no such relationship, these concerns could unnecessarily deter children from indoor swimming and/or compromise water disinfection. CONCLUSIONS: Current evidence of an association between childhood swimming and new-onset asthma is suggestive but not conclusive. Important data gaps need to be filled, particularly in exposure assessment and characterization of asthma in the very young. Participants recommended that additional evaluations using a multidisciplinary approach are needed to determine whether a clear association exists. JF - Environmental Health Perspectives AU - Weisel, Clifford P AU - Richardson, Susan D AU - Nemery, Benoit AU - Aggazzotti, Gabriella AU - Baraldi, Eugenio AU - Blatchley, Ernest R AU - Blount, Benjamin C AU - Carlsen, Kai-Haakon AU - Eggleston, Peyton A AU - Frimmel, Fritz H AU - Goodman, Michael AU - Gordon, Gilbert AU - Grinshpun, Sergey A AU - Heederik, Dirk AU - Kogevinas, Manolis AU - LaKind, Judy S AU - Nieuwenhuijsen, Mark J AU - Piper, Fontaine C AU - Sattar, Syed A PY - 2009 SP - 500 EP - 507 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Asthma KW - Pools KW - Exposure KW - Swimming pools KW - Children KW - Byproducts KW - Swimming KW - Epidemiology KW - Indoor KW - Health KW - Assessments KW - Risk KW - Data sources KW - Summaries KW - Workshops KW - Synthesis KW - Copyrights KW - Chemists KW - Multidisciplinary KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743115182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Childhood+Asthma+and+Environmental+Exposures+at+Swimming+Pools%3A+State+of+the+Science+and+Research+Recommendations&rft.au=Weisel%2C+Clifford+P%3BRichardson%2C+Susan+D%3BNemery%2C+Benoit%3BAggazzotti%2C+Gabriella%3BBaraldi%2C+Eugenio%3BBlatchley%2C+Ernest+R%3BBlount%2C+Benjamin+C%3BCarlsen%2C+Kai-Haakon%3BEggleston%2C+Peyton+A%3BFrimmel%2C+Fritz+H%3BGoodman%2C+Michael%3BGordon%2C+Gilbert%3BGrinshpun%2C+Sergey+A%3BHeederik%2C+Dirk%3BKogevinas%2C+Manolis%3BLaKind%2C+Judy+S%3BNieuwenhuijsen%2C+Mark+J%3BPiper%2C+Fontaine+C%3BSattar%2C+Syed+A&rft.aulast=Weisel&rft.aufirst=Clifford&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Biomarker Validation Study of Prenatal Chlorpyrifos Exposure within an Inner-City Cohort during Pregnancy AN - 743102096; 201004-31-0310881 (CE); 12116989 (EN) AB - BACKGROUND: We previously documented significant decreases in chlorpyrifos concentrations in maternal personal and indoor air samples among pregnant African-American and Dominican women from New York City after the 2000-2001 restrictions on its residential use. OBJECTIVE: We undertook a biomarker validation study within the same cohort to evaluate trends over time in multiple biomarkers of prenatal chlorpyrifos exposure. METHODS: Subjects were enrolled between February 2001 and May 2004 (n = 102). We measured 3,5,6-trichloro-2-pyridinol (TCPy) in postpartum meconium (n = 83), repeat prenatal maternal spot urine samples (n = 253), and postnatal urine from the mothers (n = 73) and newborns (n = 59). We measured chlorpyrifos in postnatal maternal (n = 92) and umbilical cord (n = 65) blood. RESULTS: We did not detect TCPy in infant urine, but all other biomarkers showed a highly significant decrease in detection frequencies (chi2 = 7.8-34.0, p or = 0.005) and mean ranks (p or = 0.006, Kruskal-Wallis) among subjects enrolled in 2003-2004 compared with those enrolled in 2001-2002. Chlorpyrifos in maternal personal and indoor air declined 2- to 3-fold over the same period (p 0.05). In 2001-2002 samples, TCPy levels in repeat prenatal urine were positively correlated (r = 0.23-0.56), but within-subject variability exceeded between-subject variability (intraclass correlation coefficient = 0.43); indoor air levels explained 19% of the variance in prenatal urine TCPy (p = 0.001). Meconium TCPy concentrations were positively correlated with chlorpyrifos in maternal and cord blood (r = 0.25-0.33, p 0.05) and with TCPy in maternal urine (r = 0.31, p 0.01). CONCLUSIONS: Results suggest the biomarkers are reliable dosimeters to differentiate between groups with prenatal chlorpyrifos exposures varying by a factor of 2 or more and vividly illustrate the efficacy of residential restriction on chlorpyrifos to reduce the internal dose during pregnancy. JF - Environmental Health Perspectives AU - Whyatt, Robin M AU - Garfinkel, Robin AU - Hoepner, Lori A AU - Andrews, Howard AU - Holmes, Darrell AU - Williams, Megan K AU - Reyes, Andria AU - Diaz, Diurka AU - Perera, Frederica P AU - Camann, David E AU - Barr, Dana B PY - 2009 SP - 559 EP - 567 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Chlorpyrifos KW - Urine KW - Indoor KW - Blood KW - Correlation KW - Health KW - Residential KW - Constrictions KW - Pregnancy KW - Copyrights KW - Umbilical cords KW - Rope KW - Infants KW - Trends KW - Variance KW - Correlation coefficients KW - Dosimeters KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743102096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Biomarker+Validation+Study+of+Prenatal+Chlorpyrifos+Exposure+within+an+Inner-City+Cohort+during+Pregnancy&rft.au=Whyatt%2C+Robin+M%3BGarfinkel%2C+Robin%3BHoepner%2C+Lori+A%3BAndrews%2C+Howard%3BHolmes%2C+Darrell%3BWilliams%2C+Megan+K%3BReyes%2C+Andria%3BDiaz%2C+Diurka%3BPerera%2C+Frederica+P%3BCamann%2C+David+E%3BBarr%2C+Dana+B&rft.aulast=Whyatt&rft.aufirst=Robin&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Persistent Organic Pollutant Residues in Human Fetal Liver and Placenta from Greater Montreal, Quebec: A Longitudinal Study from 1998 through 2006 AN - 743073385; 201004-31-0310875 (CE); 12116983 (EN) AB - BACKGROUND: There is general concern that persistent organic pollutants (POPs) found in the environment, wildlife, food, water, house dust, human tissues, and fluids may alter normal human physiologic activities (e.g., fetal development, immune and endocrine systems). Although the levels of some POPs [polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCs)] in these matrices have decreased after their ban, others [polybrominated diphenyl ethers (PBDEs)] have increased in recent years. OBJECTIVE: To determine the longitudinal trend of specific POPs in human fetal tissues for risk assessment purposes. METHODS: We analyzed early to mid-gestation fetal liver (n = 52) and placental (n = 60) tissues, obtained after elective abortions during 1998-2006, for selected PBDEs, PCBs, and OCs using gas chromatography-mass spectroscopy. RESULTS: Total PBDEs in fetal liver increased over time (mean +/- SE: 1998, 284.4 +/- 229.8 ng/g lipid; 2006, 1,607.7 +/- 605.9; p 0.03), whereas placental levels were generally lower, with no clear trend. Low levels of PCBs and OCs varied yearly, with no evident trend. The major analytes in 1998 were OCs (liver, 49%; placenta, 71%), whereas the major analytes in 2006 were PBDEs (liver, 89%; placenta, 98%). The 1998-2006 tissue PBDE congener profile is similar to that of DE-71, a commercial primarily pentabrominated diphenyl ether mixture manufactured in North America. CONCLUSIONS: Although commercial production of penta- and octa-brominated diphenyl ethers in North America was halted in 2004, their concentrations in fetal liver and placenta are now greater than the tissue burdens for the analyzed OCs and PCBs. Our findings also demonstrate that PBDEs accumulate within the fetal compartment at a very early stage in gestation. JF - Environmental Health Perspectives AU - Doucet, Josee AU - Tague, Brett AU - Arnold, Douglas L AU - Cooke, Gerard M AU - Hayward, Stephen AU - Goodyer, Cynthia G PY - 2009 SP - 605 EP - 610 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 4 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Liver KW - Placenta KW - Ethers KW - Human KW - Trends KW - Gestation KW - Health KW - Americas KW - Pollutants KW - Endocrine systems KW - Matrices KW - Houses KW - Heating KW - Lipids KW - Fluid flow KW - Fluid dynamics KW - Mathematical analysis KW - Low level KW - Human tissues KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743073385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Persistent+Organic+Pollutant+Residues+in+Human+Fetal+Liver+and+Placenta+from+Greater+Montreal%2C+Quebec%3A+A+Longitudinal+Study+from+1998+through+2006&rft.au=Doucet%2C+Josee%3BTague%2C+Brett%3BArnold%2C+Douglas+L%3BCooke%2C+Gerard+M%3BHayward%2C+Stephen%3BGoodyer%2C+Cynthia+G&rft.aulast=Doucet&rft.aufirst=Josee&rft.date=2009-04-01&rft.volume=117&rft.issue=4&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - [Tuberculosis control in homeless persons in European Union: more than words alone]. TT - Controlul tuberculozei la persoanele fără locuinţă din Uniunea Europeană: mai mult decât simple cuvinte. AN - 67532430; 19637759 AB - In Europe, in countries with a low incidence of tuberculosis (TB), disease is concentrated in certain subgroups of the metropolitan population, often socially excluded, such as homeless persons, illicit drug users and alcohol addicts, street dwellers with psychiatric comorbidities and ex-prisoners. The prevention and control of TB among these risk groups is complicated by delayed diagnosis, onward transmission and poor treatment adherence leading to the development of drug resistant forms of TB. In 2008, ECDC (European Center for Disease Control) published a Framework Action plan to fight TB in European Union (EU), which recognises the concentration of TB in "hard to find" and "hard to treat" populations as a major challenge to TB control efforts across the EU and encourages EU institutions in collaboration with partners to identify and disseminate good practice models in TB control. As an example, the DutchTB control model is described, based on close collaboration between hospitals, municipal public health TB clinics and complemented by two tertiary in-patient TB treatment centres. There is an urgent need to develop the knowledge base on optimal strategies for effective early diagnosis and completion of treatment of "hard to reach" groups and more EU supported collaboration of partner organisations across member states is needed to provide leadership and strategic direction, the evidence to inform policy and practice, and advocacy and support for those most at risk from TB today. JF - Pneumologia (Bucharest, Romania) AU - van Hest, Rob AU - Story, Alistair AD - Serviciul Municipal de Sănătate Publică, Rotterdam, Olanda (Municipal Public Health Service). vanhestr@ggd.rotterdam.nl PY - 2009 SP - 84 EP - 87 VL - 58 IS - 2 SN - 2067-2993, 2067-2993 KW - Index Medicus KW - Psychotic Disorders -- complications KW - European Union KW - Risk Factors KW - Humans KW - Incidence KW - Substance-Related Disorders -- complications KW - Romania -- epidemiology KW - Alcoholism -- complications KW - Population Surveillance KW - Homeless Persons -- statistics & numerical data KW - Tuberculosis, Pulmonary -- prevention & control KW - Tuberculosis, Pulmonary -- diagnosis KW - Tuberculosis, Pulmonary -- epidemiology KW - Tuberculosis, Pulmonary -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67532430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pneumologia+%28Bucharest%2C+Romania%29&rft.atitle=%5BTuberculosis+control+in+homeless+persons+in+European+Union%3A+more+than+words+alone%5D.&rft.au=van+Hest%2C+Rob%3BStory%2C+Alistair&rft.aulast=van+Hest&rft.aufirst=Rob&rft.date=2009-04-01&rft.volume=58&rft.issue=2&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Pneumologia+%28Bucharest%2C+Romania%29&rft.issn=20672993&rft_id=info:doi/ LA - rum DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-27 N1 - Date created - 2009-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Searching for HAdV-52, the putative gastroenteritis-associated human adenovirus serotype in Southern Hungary. AN - 67459089; 19579697 AB - Human adenovirus (HAdV) serotype 52 has recently been discovered in the United States in samples from human patients with gastroenteritis of unknown etiology and is suspected to be a new human enteric pathogen. The aim of the present pilot study was to investigate whether this virus is circulating in the population of Southern Hungary by screening stool specimens collected from gastroenteritis cases and communal sewage samples in the area of Baranya County. A total of 209 diarrheic stool (124 from children and 85 from adults) and 45 influent sewage samples were screened for HAdV-52 by PCR using a primer pair specific to the gene of 12.5K protein in the E3 genomic region. The novel human adenovirus was not detected in any of the tested samples, suggesting that HAdV-52 was not circulating in the target population and the area during the study period. Since temporal and geographical fluctuations may markedly affect the epidemiology of human enteric pathogens, additional investigations are required to gain more in-depth insights into the ecology of this novel adenovirus. JF - The new microbiologica AU - Bányai, Krisztián AU - Martella, Vito AU - Meleg, Edina AU - Kisfali, Péter AU - Péterfi, Zoltán AU - Benkö, Mária AU - Melegh, Béla AU - Szucs, György AD - Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs, Hungary. bkrota@hotmail.com Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 185 EP - 188 VL - 32 IS - 2 SN - 1121-7138, 1121-7138 KW - DNA, Viral KW - 0 KW - Sewage KW - Index Medicus KW - Polymerase Chain Reaction KW - DNA, Viral -- analysis KW - Sewage -- virology KW - Humans KW - Feces -- virology KW - Adult KW - Hungary -- epidemiology KW - Serotyping KW - Pilot Projects KW - Child KW - DNA, Viral -- genetics KW - Adenovirus Infections, Human -- virology KW - Adenovirus Infections, Human -- epidemiology KW - Gastroenteritis -- etiology KW - Adenoviruses, Human -- genetics KW - Adenoviruses, Human -- isolation & purification KW - Adenoviruses, Human -- classification KW - Adenovirus Infections, Human -- complications KW - Gastroenteritis -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67459089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+new+microbiologica&rft.atitle=Searching+for+HAdV-52%2C+the+putative+gastroenteritis-associated+human+adenovirus+serotype+in+Southern+Hungary.&rft.au=B%C3%A1nyai%2C+Kriszti%C3%A1n%3BMartella%2C+Vito%3BMeleg%2C+Edina%3BKisfali%2C+P%C3%A9ter%3BP%C3%A9terfi%2C+Zolt%C3%A1n%3BBenk%C3%B6%2C+M%C3%A1ria%3BMelegh%2C+B%C3%A9la%3BSzucs%2C+Gy%C3%B6rgy&rft.aulast=B%C3%A1nyai&rft.aufirst=Kriszti%C3%A1n&rft.date=2009-04-01&rft.volume=32&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=The+new+microbiologica&rft.issn=11217138&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The NIOSH Retrospective Pesticide Reference Database. AN - 67325973; 19496343 AB - For the National Institute for Occupational Safety and Health (NIOSH) case-control study of glioma among non-metropolitan residents, pesticide information was considered critical. Responses to open-ended questions about pesticide exposures had to be grouped for analysis. Our aim was to classify pesticide responses in biologically relevant categories. We built the NIOSH Retrospective Pesticide Reference Database (NIOSH-RPRD) on over 1000 pesticide products and chemicals, particularly those likely to be used in the upper Midwest, using multiple sources. We obtained first and last years of product registration and product pesticide ingredients and their relative weights from the U.S. Environmental Protection Agency's Pesticide Product Information System. We added fields for pesticide class (organophosphate, etc.), carcinogenicity ratings, and evidence regarding endocrine-disrupting activity. Participant data were merged with the database, allowing each product recalled by a respondent to be linked to one or more chemicals, as appropriate. Respondents named 1347 different pesticides (or pesticide-targeted species) used on the farm, at non-farm jobs, or at home. Database usefulness was assessed by comparing numbers of responses naming actual chemicals to total responses linked to those chemicals. Sixty percent of farm pesticide, 59% of non-farm occupational, and 65% of house and garden responses named products, not chemicals. Among farm pesticide users, 182 (46%) reported using a total of 440 pesticides 1 to 40 years (mean 8.5 years) before those pesticides actually were marketed. The NIOSH-RPRD, now available to other investigators, has been a useful tool for us and other researchers to evaluate, group, and correct pesticide responses. JF - Journal of agricultural safety and health AU - Ruder, A M AU - Butler, M A AU - Sanderson, W T AU - Carreón, T AU - Waters, M A AU - Zivkovich, Z E AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA. amr2@cdc.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 143 EP - 156 VL - 15 IS - 2 SN - 1074-7583, 1074-7583 KW - Pesticides KW - 0 KW - Index Medicus KW - United States KW - Young Adult KW - Aged, 80 and over KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Retrospective Studies KW - Databases, Factual KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Risk Assessment KW - Occupational Exposure -- adverse effects KW - Agriculture -- statistics & numerical data KW - National Institute for Occupational Safety and Health (U.S.) KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67325973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+safety+and+health&rft.atitle=The+NIOSH+Retrospective+Pesticide+Reference+Database.&rft.au=Ruder%2C+A+M%3BButler%2C+M+A%3BSanderson%2C+W+T%3BCarre%C3%B3n%2C+T%3BWaters%2C+M+A%3BZivkovich%2C+Z+E&rft.aulast=Ruder&rft.aufirst=A&rft.date=2009-04-01&rft.volume=15&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+safety+and+health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2009-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Venomous spiders, snakes, and scorpions in the United States. AN - 67267274; 19455950 AB - Venomous bites and stings are complex poisonings that have local and systemic effects. Mild envenomations can be treated with supportive care. Severe envenomations can be treated definitively with species-specific antivenom, although the use of these products has potential risk of immediate and a more delayed onset form of hypersensitivity reactions. Consultation with a toxicologist is recommended to help guide therapy. Field treatments such as tourniquets and incision likely cause more harm than benefit and should be avoided. JF - Pediatric annals AU - Holve, Steve AD - Indian Health Service, Tuba City Regional Health Care Corporation,Tuba City, Arizona 86045, USA. steve.holve@tchealth.org Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 210 EP - 217 VL - 38 IS - 4 SN - 0090-4481, 0090-4481 KW - Antivenins KW - 0 KW - Venoms KW - Index Medicus KW - Severity of Illness Index KW - Animals KW - Emergency Medical Services -- methods KW - Pediatrics -- methods KW - Humans KW - Venoms -- pharmacokinetics KW - Child KW - Species Specificity KW - Antivenins -- therapeutic use KW - Child, Preschool KW - Spider Bites -- metabolism KW - Snakes -- classification KW - Scorpions -- classification KW - Snake Bites -- diagnosis KW - Snake Bites -- drug therapy KW - Snake Bites -- metabolism KW - Spiders -- classification KW - Spider Bites -- drug therapy KW - Spider Bites -- diagnosis KW - Scorpion Stings UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67267274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+annals&rft.atitle=Venomous+spiders%2C+snakes%2C+and+scorpions+in+the+United+States.&rft.au=Holve%2C+Steve&rft.aulast=Holve&rft.aufirst=Steve&rft.date=2009-04-01&rft.volume=38&rft.issue=4&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Pediatric+annals&rft.issn=00904481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-12 N1 - Date created - 2009-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Application of deadenylase electrochemiluminescence assay for ricin to foods in a plate format. AN - 67226439; 19435248 AB - A recently developed bead-based deadenylase electrochemiluminescence assay for ricin is simple and sensitive in its ability to detect ricin, based on the catalytic activity of the toxin subunit, ricin A chain. The assay was modified to work in a 96-well plate format and evaluated by using juice samples. The plate-based assay, unlike the bead-based assay, includes wash steps that enable the removal of food particles. These steps minimize matrix effects and improve the signal-to-noise ratios and limits of detection (LOD). The LOD values for ricin in apple juice, vegetable juice, and citrate buffer by using the bead-based assay were 0.4, 1, and 0.1 microg/ml, respectively. In contrast, the LOD values for ricin by using the plate-based assay were 0.04, 0.1, and 0.04 microg/ml in apple juice, vegetable juice, and citrate buffer, respectively. The plate-based assay displayed three- to 10-fold lower LOD values than did the bead-based assay. Signal-to-noise ratios for the plate-based assay were comparable to those for the bead-based assay for ricin in citrate buffer, but 2- to 4.5-fold higher when the plate-based assay was used for analysis of juice samples. JF - Journal of food protection AU - Cho, Chung Y AU - Keener, William K AU - Garber, Eric A E AD - Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, Maryland 20740, USA. Chung.Cho@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 903 EP - 906 VL - 72 IS - 4 SN - 0362-028X, 0362-028X KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - Food Analysis -- methods KW - Electrochemical Techniques -- methods KW - Fluorescence KW - Food Contamination -- analysis KW - Ricin -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67226439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Application+of+deadenylase+electrochemiluminescence+assay+for+ricin+to+foods+in+a+plate+format.&rft.au=Cho%2C+Chung+Y%3BKeener%2C+William+K%3BGarber%2C+Eric+A+E&rft.aulast=Cho&rft.aufirst=Chung&rft.date=2009-04-01&rft.volume=72&rft.issue=4&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-14 N1 - Date created - 2009-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association between swimming pool operator certification and reduced pool chemistry violations--Nebraska, 2005-2006. AN - 67197552; 19408431 AB - Previous studies have recommended mandatory education for all public pool operators, but substantiating data are limited. This study evaluates associations between pool operator certification and chemistry violations by using 2005-2006 Nebraska routine pool inspection reports. Training and certification for nonmunicipal pool operators are only required in two Nebraska counties. Free chlorine violations for nonmunicipal pool inspections were compared in counties with and without certified operator requirements. To control for water supply pH, inspections from nonmunicipal pools with shared-source water in two counties (one requiring certification) were compared for concurrent pH and free chlorine violations. Compared with locations that require certified operators, free chlorine violations and concurrent pH and free chlorine violations were twice as likely in locations without certification. As a result, pools without required operator certification might pose greater health risks. These results demonstrate the benefit of requiring pool operator certification to help prevent recreational water illnesses. JF - Journal of environmental health AU - Buss, Bryan F AU - Safranek, Thomas J AU - Magri, Julie M AU - Török, Thomas J AU - Beach, Michael J AU - Foley, Brett P AD - Nebraska Department of Health and Human Services, Division of Public Health, Lincoln, NE 68509, USA. bryan.buss@nebraska.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 36 EP - 40 VL - 71 IS - 8 SN - 0022-0892, 0022-0892 KW - Chlorine KW - 4R7X1O2820 KW - Index Medicus KW - Cross-Sectional Studies KW - Chlorine -- analysis KW - Halogenation KW - Hydrogen-Ion Concentration KW - Humans KW - Chlorine -- adverse effects KW - Water Microbiology KW - Nebraska KW - Facility Regulation and Control KW - Swimming Pools -- standards KW - Administrative Personnel KW - Water Purification -- standards KW - Certification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67197552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+health&rft.atitle=Association+between+swimming+pool+operator+certification+and+reduced+pool+chemistry+violations--Nebraska%2C+2005-2006.&rft.au=Buss%2C+Bryan+F%3BSafranek%2C+Thomas+J%3BMagri%2C+Julie+M%3BT%C3%B6r%C3%B6k%2C+Thomas+J%3BBeach%2C+Michael+J%3BFoley%2C+Brett+P&rft.aulast=Buss&rft.aufirst=Bryan&rft.date=2009-04-01&rft.volume=71&rft.issue=8&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+health&rft.issn=00220892&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-02 N1 - Date created - 2009-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic stability of vaccine strain Salmonella Typhi Ty21a over 25 years. AN - 67122460; 19121604 AB - The attenuated live bacterial vaccine strain Salmonella enterica Serovar Typhi Ty21a is the main constituent of Vivotif, the only licensed oral vaccine against typhoid fever. The strain was developed in the 1970s by chemical mutagenesis. In the course of this mutagenesis, a number of mutations were introduced into the vaccine strain. Characterisation of the vaccine strain during development as well as release of master- and working seed lots (MSL and WSL) and commercial batches is based on phenotypic assays assessing microbiological and biochemical characteristics of Ty21a. In the current study, we have analysed by DNA sequencing the specific mutations originally correlated with the attenuation of strain Ty21a. These data demonstrate the stability of these mutations for MSLs and WSLs of Ty21a produced between 1980 and 2005. Finally, we have confirmed the correlation of these genetic mutations with the expected phenotypic attenuations for the seed lots used in vaccine manufacture over 25 years. JF - International journal of medical microbiology : IJMM AU - Kopecko, Dennis J AU - Sieber, Heike AU - Ures, Jose A AU - Fürer, Andreas AU - Schlup, Jacqueline AU - Knof, Ulrich AU - Collioud, Andre AU - Xu, Deqi AU - Colburn, Kevin AU - Dietrich, Guido AD - Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, NIH Campus, Bldg. 29/420, HFM440, Bethesda, MD 20892, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 233 EP - 246 VL - 299 IS - 4 KW - DNA, Bacterial KW - 0 KW - Salmonella Vaccines KW - Vaccines, Attenuated KW - Virulence Factors KW - Index Medicus KW - Humans KW - DNA, Bacterial -- genetics KW - Vaccines, Attenuated -- genetics KW - Point Mutation KW - Virulence Factors -- genetics KW - Sequence Analysis, DNA KW - Mutation, Missense KW - Salmonella typhi -- genetics KW - Salmonella Vaccines -- genetics KW - Genomic Instability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67122460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+medical+microbiology+%3A+IJMM&rft.atitle=Genetic+stability+of+vaccine+strain+Salmonella+Typhi+Ty21a+over+25+years.&rft.au=Kopecko%2C+Dennis+J%3BSieber%2C+Heike%3BUres%2C+Jose+A%3BF%C3%BCrer%2C+Andreas%3BSchlup%2C+Jacqueline%3BKnof%2C+Ulrich%3BCollioud%2C+Andre%3BXu%2C+Deqi%3BColburn%2C+Kevin%3BDietrich%2C+Guido&rft.aulast=Kopecko&rft.aufirst=Dennis&rft.date=2009-04-01&rft.volume=299&rft.issue=4&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=International+journal+of+medical+microbiology+%3A+IJMM&rft.issn=1618-0607&rft_id=info:doi/10.1016%2Fj.ijmm.2008.09.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-19 N1 - Date created - 2009-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijmm.2008.09.003 ER - TY - JOUR T1 - Nitric oxide synthase gene polymorphisms and prostate cancer risk. AN - 67119149; 19168583 AB - Nitric oxide (NO) induces cytotoxicity and angiogenesis, and may play a role in prostate carcinogenesis, potentially modulated by environmental exposures. We evaluated the association of prostate cancer with genetic polymorphisms in two genes related to intracellular NO: NOS2A [inducible nitric oxide synthase (NOS); -2892T>C, Ex16 + 14C>T (S608L), IVS16 + 88T>G and IVS20 + 524G>A] and NOS3 [endothelial NOS; IVS1-762C>T, Ex7-43C>T (D258D), IVS7-26A>G, Ex8-63G>T (E298D) and IVS15-62G>T]. Prostate cancer cases (n = 1320) from the screening arm of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial were frequency matched to controls (n = 1842), by age, race, time since initial screening and year of blood draw. An antioxidant score [range 3-12; low (3-7) versus high (8-12)] was created by summing the quartile levels of vitamin E, beta-carotene and lycopene, which were coded from 1 to 4, respectively. The global tests for all eight single-nucleotide polymorphisms (SNPs) (excluding NOS2A-2892T>C, with low minor allele frequency) were statistically significant for prostate cancer (P = 0.005), especially for aggressive cancer (stage III-IV or Gleason score > or = 7) (P = 0.01). The NOS2A IVS16 + 88 GT/TT was associated with increased prostate cancer risk (odds ratio = 1.24, 95% confidence interval = 1.00-1.54), whereas the IVS20 + 524 AG/GG was associated with decreased risk (0.77, 0.66-0.90). The NOS3 IVS7-26GG was associated with increased prostate cancer risk (1.33, 1.07-1.64). All these SNPs showed significant associations with aggressive cancer and not for non-aggressive cancer. In the evaluation of effect modification, the effect of the NOS2A IVS16 + 88 GT/TT on aggressive cancer was stronger among subjects with higher antioxidant intake (1.61, 1.18-2.19; P(interaction) = 0.01). Our results suggest that NOS gene polymorphisms are genetic susceptibility factors for aggressive prostate cancer. JF - Carcinogenesis AU - Lee, Kyoung-Mu AU - Kang, Daehee AU - Park, Sue Kyung AU - Berndt, Sonja I AU - Reding, Douglas AU - Chatterjee, Nilanjan AU - Chanock, Stephen AU - Huang, Wen-Yi AU - Hayes, Richard B AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. leekyou@mail.nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 621 EP - 625 VL - 30 IS - 4 KW - Antioxidants KW - 0 KW - beta Carotene KW - 01YAE03M7J KW - Vitamin E KW - 1406-18-4 KW - Carotenoids KW - 36-88-4 KW - NOS2 protein, human KW - EC 1.14.13.39 KW - NOS3 protein, human KW - Nitric Oxide Synthase Type II KW - Nitric Oxide Synthase Type III KW - lycopene KW - SB0N2N0WV6 KW - Index Medicus KW - beta Carotene -- administration & dosage KW - Genotype KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Carotenoids -- administration & dosage KW - Vitamin E -- administration & dosage KW - Male KW - Nitric Oxide Synthase Type III -- genetics KW - Polymorphism, Genetic -- genetics KW - Prostatic Neoplasms -- blood KW - Prostatic Neoplasms -- genetics KW - Prostatic Neoplasms -- prevention & control KW - Nitric Oxide Synthase Type II -- genetics KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67119149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Nitric+oxide+synthase+gene+polymorphisms+and+prostate+cancer+risk.&rft.au=Lee%2C+Kyoung-Mu%3BKang%2C+Daehee%3BPark%2C+Sue+Kyung%3BBerndt%2C+Sonja+I%3BReding%2C+Douglas%3BChatterjee%2C+Nilanjan%3BChanock%2C+Stephen%3BHuang%2C+Wen-Yi%3BHayes%2C+Richard+B&rft.aulast=Lee&rft.aufirst=Kyoung-Mu&rft.date=2009-04-01&rft.volume=30&rft.issue=4&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-28 N1 - Date created - 2009-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Antioxid Redox Signal. 2001 Apr;3(2):203-13 [11396476] Eur J Cancer Prev. 2002 Aug;11(4):343-50 [12195160] J Hypertens. 2002 Oct;20(10):2023-7 [12359981] Cancer Lett. 2003 Jan 10;189(1):85-90 [12445681] Int J Cancer. 2003 Apr 10;104(3):274-82 [12569550] Cancer Lett. 2004 Jul 8;210(1):63-71 [15172122] Cancer Metastasis Rev. 1998 Mar;17(1):91-106 [9544425] Cancer. 1998 May 15;82(10):1897-903 [9587122] Carcinogenesis. 1998 May;19(5):711-21 [9635855] J Clin Oncol. 2005 Jan 10;23(2):368-77 [15637399] Exp Mol Med. 2005 Oct 31;37(5):497-506 [16264276] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Cancer Res. 2006 Jul 1;66(13):6459-62 [16818612] Lancet Oncol. 2007 Feb;8(2):111-8 [17267325] Oncogene. 2007 Mar 22;26(13):1875-84 [16983333] Nat Genet. 2007 May;39(5):645-9 [17401363] Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1581-6 [17646272] J Natl Cancer Inst. 2007 Oct 17;99(20):1525-33 [17925536] Breast Cancer Res Treat. 2007 Dec;106(3):433-8 [17262178] J Natl Cancer Inst. 2007 Dec 19;99(24):1836-44 [18073375] Nat Genet. 2008 Mar;40(3):310-5 [18264096] Urol Res. 2001 Feb;29(1):23-8 [11310211] Gynecol Oncol. 2002 Aug;86(2):134-7 [12144818] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp028 ER - TY - JOUR T1 - Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China. AN - 67117691; 19168589 AB - Biliary tract cancers, encompassing gallbladder, extrahepatic bile duct and ampulla of Vater cancers, are uncommon but often fatal malignancies. Hormone-related factors, including parity, oral contraceptive use, obesity, and gallstones, have been implicated in the etiology of these cancers. To further clarify the role of hormones in biliary tract cancers and biliary stones, we genotyped 18 single-nucleotide polymorphisms (SNPs) in nine genes involved in steroid hormone biosynthesis, metabolism and transport in a population-based case-control study in Shanghai, China. This study included subjects who completed an interview and provided blood, which totaled 411 biliary tract cancer and 893 biliary stone patients and 786 healthy Shanghai residents. The CYP1A1 IVS1 + 606 (rs2606345) T allele was associated with gallbladder [odds ratio (OR) = 2.0, 95% confidence interval (CI), 1.3-3.0] and bile duct cancers (OR = 1.8, 95% CI = 1.1-3.1), whereas the CYP1A1 Ex7 + 131 (rs1048943) G allele was associated with ampulla of Vater cancer (OR = 2.9, 95% CI = 1.5-5.4). After taking into account multiple comparisons for SNPs within each gene, CYP1A1 was significantly associated with gallbladder (P = 0.004) and ampulla of Vater cancers (P = 0.01), but borderline with bile duct cancer (P = 0.06). The effect of CYP1A1 IVS1 + 606 on gallbladder cancer was more pronounced among non-obese (body mass index < 23) (OR = 3.3, 95% CI = 1.8-6.1; P interaction = 0.001). Among women taking oral contraceptives, the effect of SHBG Ex8 + 6 (rs6259) on gallbladder cancer (OR = 6.7, 95% CI = 2.2-20.5; P interaction = 0.001) and stones (OR = 2.3, 95% CI = 1.1-4.9; P-interaction = 0.05) was statistically significant. Our findings suggest that common variants in hormone-related genes contribute to the risk of biliary tract cancers and stones, possibly by modulating hormone metabolism. JF - Carcinogenesis AU - Park, Sue K AU - Andreotti, Gabriella AU - Sakoda, Lori C AU - Gao, Yu-Tang AU - Rashid, Asif AU - Chen, Jinbo AU - Chen, Bingshu E AU - Rosenberg, Philip S AU - Shen, Ming-Chang AU - Wang, Bing-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Yeager, Meredith AU - Chanock, Stephen AU - Hsing, Ann W AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, EPS 5024, MSC 7234, Bethesda, MD 20892-7234, USA. suepark@snu.ac.kr Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 606 EP - 614 VL - 30 IS - 4 KW - Biomarkers, Tumor KW - 0 KW - Contraceptives, Oral, Hormonal KW - Hormones KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Index Medicus KW - Humans KW - Prognosis KW - Aged KW - Body Mass Index KW - Risk Factors KW - China -- epidemiology KW - DNA -- blood KW - Adult KW - DNA -- genetics KW - Case-Control Studies KW - Interviews as Topic KW - Middle Aged KW - Contraceptives, Oral, Hormonal -- administration & dosage KW - Female KW - Male KW - Gallstones -- epidemiology KW - Biomarkers, Tumor -- genetics KW - Cytochrome P-450 CYP1A1 -- genetics KW - Biliary Tract Neoplasms -- epidemiology KW - Biliary Tract Neoplasms -- blood KW - Biliary Tract Neoplasms -- genetics KW - Gallstones -- blood KW - Hormones -- metabolism KW - Polymorphism, Single Nucleotide -- genetics KW - Gallstones -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67117691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Variants+in+hormone-related+genes+and+the+risk+of+biliary+tract+cancers+and+stones%3A+a+population-based+study+in+China.&rft.au=Park%2C+Sue+K%3BAndreotti%2C+Gabriella%3BSakoda%2C+Lori+C%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BChen%2C+Jinbo%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip+S%3BShen%2C+Ming-Chang%3BWang%2C+Bing-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BYeager%2C+Meredith%3BChanock%2C+Stephen%3BHsing%2C+Ann+W&rft.aulast=Park&rft.aufirst=Sue&rft.date=2009-04-01&rft.volume=30&rft.issue=4&rft.spage=606&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-28 N1 - Date created - 2009-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):3-28 [10667460] Menopause. 2000 May-Jun;7(3):162-7 [10810961] Pharmacogenetics. 2000 Aug;10(6):519-30 [10975606] Ann Intern Med. 2001 Oct 2;135(7):493-501 [11578152] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Trends Endocrinol Metab. 2002 Apr;13(3):122-8 [11893526] J Exp Clin Cancer Res. 2002 Mar;21(1):119-24 [12071517] Int J Cancer. 2002 Jun 10;99(5):762-3 [12115514] J Endocrinol Invest. 2002 Nov;25(10):893-8 [12508952] Int J Cancer. 2003 Jun 20;105(3):408-12 [12704678] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D528-32 [14681474] Acta Endocrinol Suppl (Copenh). 1980;232:1-127 [6770572] Recent Prog Horm Res. 1982;38:457-510 [6750727] J Natl Cancer Inst. 1985 Apr;74(4):741-5 [3857369] Cancer. 1987 Jun 15;59(12):2112-6 [3567872] Jpn J Cancer Res. 1989 Oct;80(10):932-8 [2515177] J Clin Epidemiol. 1990;43(7):687-92 [2370576] J Clin Invest. 1991 Jan;87(1):237-46 [1845870] Contraception. 1991 Jun;43(6):667-93 [1868737] J Toxicol Environ Health. 1993 Oct-Nov;40(2-3):309-16 [7901425] Int J Cancer. 1994 Apr 15;57(2):146-53 [8157350] Cancer Causes Control. 1994 May;5(3):267-72 [8061176] Toxicol Lett. 1995 May;77(1-3):357-62 [7618162] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Eur J Cancer Prev. 1996 Aug;5(4):241-7 [8894561] J Cell Biochem Suppl. 1996;25:15-22 [9027593] J Natl Cancer Inst. 1997 Aug 6;89(15):1132-8 [9262251] Int J Cancer. 1998 Jan 30;75(3):368-70 [9455795] Am J Gastroenterol. 1999 Jan;94(1):149-52 [9934746] Hepatogastroenterology. 1999 May-Jun;46(27):1529-32 [10430289] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Expert Opin Drug Saf. 2006 Jan;5(1):117-29 [16370961] J Sex Med. 2006 Jan;3(1):104-13 [16409223] Int J Cancer. 2006 Apr 1;118(7):1591-602 [16397865] Int J Cancer. 2006 Jun 1;118(11):2847-53 [16381022] Fertil Steril. 2006 May;85(5):1319-40 [16647374] Carcinogenesis. 2006 Jun;27(6):1251-6 [16361272] Stat Med. 2006 Sep 30;25(18):3134-49 [16252274] J Gastroenterol Hepatol. 2006 Nov;21(11):1737-43 [16984599] Br J Cancer. 2007 Dec 3;97(11):1577-82 [18000509] Int J Cancer. 2008 Apr 15;122(8):1849-53 [18076042] Cancer Res. 2008 Aug 1;68(15):6442-52 [18676870] Br J Cancer. 2008 Sep 2;99(5):811-5 [18728671] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp024 ER - TY - JOUR T1 - Agreement between task-based estimates of the full-shift noise exposure and the full-shift noise dosimetry. AN - 67086658; 19282390 AB - Noise assessments have been conducted using full-shift dosimetry and short-term task-based measurements. Advantages of the task-based method include the opportunity to directly identify high-noise exposure tasks and to target control measures, as well as obtain estimates of task-based full-shift exposures; however, there is little empirical evidence comparing the two methods. National Institute for Occupational Safety and Health assessed noise exposures at three industrial facilities using dosimetry and task-based methods with the objective of comparing the two strategies and assessing the degree of agreement and causes of disagreement. Eight indices of task-based full-shift exposures were created from task-based sampling using three methods to assess time-at-task (direct observation by industrial hygienist, end-of-shift worker estimates and supervisor estimates) and three methods to assign noise levels to tasks [direct measurement, arithmetic mean (AM) and geometric mean (GM)]. We assessed aspects of agreement (precision, bias and absolute agreement) using Bland-Altman plots and concordance correlation coefficient (CCC). Overall, the task-based methods worked fairly well, with mean biases less than +/-2.8 dBA and precision ranges of 3.3-4.4 dBA. By all measures, task-based full-shift estimates based on supervisor assessment of time-at-task agreed most poorly with the dosimetry data. The task-based full-shift estimates based on worker estimates of time-at-task generally agreed as well as those based on direct observation. For task noise level, task-based full-shift estimates based on directly measured task agreed the best with dosimetry data, while agreement for task-based indices based on task AM or GM was variable. Overall, the task-based full-shift estimates based on direct observation task and direct measured task noise level achieved the best agreement with the dosimetry data (CCC 0.84) with 95% of their differences being within 7.4 dBA and 56% of the differences <3 dBA. For this index, a high degree of accuracy was observed (accuracy coefficient = 0.96) with major cause of disagreement arising from a lack of precision (precision coefficient = 0.88). When the measurements were classified by job characteristics, significant improvements in the degree of agreement were observed in the low job mobility, low job complexity and low job variability categories. Our data suggest that a high degree of absolute agreement can be achieved between the task-based and dosimetry-based estimates of full-shift exposures. The task-based approach that uses worker reports combined with task AM or GM levels is similar to the more time-intensive direct observation method to estimate full-shift exposures. JF - The Annals of occupational hygiene AU - Virji, M Abbas AU - Woskie, Susan R AU - Waters, Martha AU - Brueck, Scott AU - Stancescu, Daniel AU - Gore, Rebecca AU - Estill, Cheryl AU - Prince, Mary AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. mvirji@cdc.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 201 EP - 214 VL - 53 IS - 3 KW - Index Medicus KW - Occupational Health KW - Humans KW - Job Description KW - Task Performance and Analysis KW - Observer Variation KW - Environmental Monitoring -- methods KW - Occupational Exposure -- statistics & numerical data KW - Noise, Occupational -- statistics & numerical data KW - Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67086658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Agreement+between+task-based+estimates+of+the+full-shift+noise+exposure+and+the+full-shift+noise+dosimetry.&rft.au=Virji%2C+M+Abbas%3BWoskie%2C+Susan+R%3BWaters%2C+Martha%3BBrueck%2C+Scott%3BStancescu%2C+Daniel%3BGore%2C+Rebecca%3BEstill%2C+Cheryl%3BPrince%2C+Mary&rft.aulast=Virji&rft.aufirst=M&rft.date=2009-04-01&rft.volume=53&rft.issue=3&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmep010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-14 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Occup Hyg. 2012 Jan;56(1):1-9 [22156566] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/mep010 ER - TY - JOUR T1 - Presence of tungsten-containing fibers in tungsten refining and manufacturing processes. AN - 67086609; 19126624 AB - In tungsten refining and manufacturing processes, a series of tungsten oxides are typically formed as intermediates in the production of tungsten powder. The present study was conducted to characterize airborne tungsten-containing fiber dimensions, elemental composition and concentrations in the US tungsten refining and manufacturing industry. During the course of normal employee work activities, seven personal breathing zone and 62 area air samples were collected and analyzed using National Institute for Occupational Safety and Health (NIOSH) fiber sampling and counting methods to determine dimensions, composition and airborne concentrations of fibers. Mixed models were used to identify relationships between potential determinants and airborne fiber concentrations. Results from transmission electron microscopy analyses indicated that airborne fibers with length >0.5 microm, diameter >0.01 microm and aspect ratios > or =3:1 were present on 35 of the 69 air samples collected. Overall, the airborne fibers detected had a geometric mean length approximately 3 microm and diameter approximately 0.3 microm. Ninety-seven percent of the airborne fibers identified were in the thoracic fraction (i.e. aerodynamic diameter 5 microm, diameter or = 5:1), airborne fiber concentrations ranged from below the limit of detection to 0.085 fibers cm(-3), with calcining being associated with the highest airborne concentrations. The mixed model procedure indicated that process temperature had a marginally significant relationship to airborne fiber concentration. This finding was expected since heated processes such as calcining created the highest airborne fiber concentrations. The finding of airborne tungsten-containing fibers in this occupational setting needs to be confirmed in similar settings and demonstrates the need to obtain information on the durability and associated health effects of these fibers. JF - The Annals of occupational hygiene AU - McKernan, John L AU - Toraason, Mark A AU - Fernback, Joseph E AU - Petersen, Martin R AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. mckernan.john@epa.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 215 EP - 224 VL - 53 IS - 3 KW - Air Pollutants, Occupational KW - 0 KW - Particulate Matter KW - Tungsten KW - V9306CXO6G KW - Index Medicus KW - United States KW - Occupational Health KW - Particle Size KW - Humans KW - Models, Statistical KW - Environmental Monitoring -- methods KW - Air Pollutants, Occupational -- analysis KW - Tungsten -- analysis KW - Particulate Matter -- analysis KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67086609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Presence+of+tungsten-containing+fibers+in+tungsten+refining+and+manufacturing+processes.&rft.au=McKernan%2C+John+L%3BToraason%2C+Mark+A%3BFernback%2C+Joseph+E%3BPetersen%2C+Martin+R&rft.aulast=McKernan&rft.aufirst=John&rft.date=2009-04-01&rft.volume=53&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmen078 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-14 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: AIHAJ. 2001 Mar-Apr;62(2):195-8 [11331991] Free Radic Biol Med. 1988;5(5-6):403-8 [3076883] J Occup Environ Hyg. 2008 Jul;5(7):463-74 [18569509] Am Ind Hyg Assoc J. 1996 Sep;57(9):820-4 [8865590] Sci Total Environ. 1996 Nov 18;191(1-2):153-67 [8885428] Chest. 1992 Oct;102(4):1310 [1395806] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/men078 ER - TY - JOUR T1 - Comparison of membrane assisted solvent extraction, stir bar sorptive extraction, and solid phase microextraction in analysis of tetramine in food. AN - 67086373; 19266557 AB - Three environmentally friendly extraction techniques, membrane assisted solvent extraction (MASE), stir bar sorptive extraction (SBSE), and headspace solid phase microextraction (HS-SPME), were compared for the direct analysis of the highly toxic rodenticide tetramine in food. The optimized MASE method was applied to seven foods fortified with tetramine and compared to previously reported SBSE and HS-SPME results. Parameters such as the standard addition linearity (MASE (0.964-0.999), SBSE (0.966-0.999), HS-SPME (0.955-0.999)), recovery (MASE (12-86%), SBSE (36-130%), HS-SPME (50-200%)), reproducibility (MASE (3.0-30%), SBSE (4.4-9.6%), HS-SPME (1-12%)), and LOD (MASE (1.6-6.4 ng/g), SBSE (0.2-2.1 ng/g), HS-SPME (0.9-4.3 ng/g)) were compared. JF - Journal of separation science AU - De Jager, Lowri S AU - Perfetti, Gracia A AU - Diachenko, Gregory W AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 1081 EP - 1086 VL - 32 IS - 7 KW - Bridged-Ring Compounds KW - 0 KW - Solvents KW - tetramethylenedisulfotetramine KW - F6TS3WME05 KW - Index Medicus KW - Molecular Structure KW - Food KW - Linear Models KW - Food Analysis -- methods KW - Bridged-Ring Compounds -- chemistry KW - Solid Phase Microextraction -- instrumentation KW - Food Analysis -- instrumentation KW - Solid Phase Microextraction -- methods KW - Bridged-Ring Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67086373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+separation+science&rft.atitle=Comparison+of+membrane+assisted+solvent+extraction%2C+stir+bar+sorptive+extraction%2C+and+solid+phase+microextraction+in+analysis+of+tetramine+in+food.&rft.au=De+Jager%2C+Lowri+S%3BPerfetti%2C+Gracia+A%3BDiachenko%2C+Gregory+W&rft.aulast=De+Jager&rft.aufirst=Lowri&rft.date=2009-04-01&rft.volume=32&rft.issue=7&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=Journal+of+separation+science&rft.issn=1615-9314&rft_id=info:doi/10.1002%2Fjssc.200800576 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-26 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jssc.200800576 ER - TY - JOUR T1 - Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles. AN - 67045150; 19162059 AB - In general, gold nanoparticles are recognized as being as nontoxic. Still, there have been some reports on their toxicity, which has been shown to depend on the physical dimension, surface chemistry, and shape of the nanoparticles. In this study, we carry out an in vivo toxicity study using 13 nm-sized gold nanoparticles coated with PEG (MW 5000). In our findings the 13 nm sized PEG-coated gold nanoparticles were seen to induce acute inflammation and apoptosis in the liver. These nanoparticles were found to accumulate in the liver and spleen for up to 7 days after injection and to have long blood circulation times. In addition, transmission electron microscopy showed that numerous cytoplasmic vesicles and lysosomes of liver Kupffer cells and spleen macrophages contained the PEG-coated gold nanoparticles. These findings of toxicity and kinetics of PEG-coated gold nanoparticles may have important clinical implications regarding the safety issue as PEG-coated gold nanoparticles are widely used in biomedical applications. JF - Toxicology and applied pharmacology AU - Cho, Wan-Seob AU - Cho, Minjung AU - Jeong, Jinyoung AU - Choi, Mina AU - Cho, Hea-Young AU - Han, Beom Seok AU - Kim, Sheen Hee AU - Kim, Hyoung Ook AU - Lim, Yong Taik AU - Chung, Bong Hyun AU - Jeong, Jayoung AD - Division of Toxicologic Pathology, Department of Toxicological Research, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung-ku, Seoul 122-704, Republic of Korea. Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 16 EP - 24 VL - 236 IS - 1 KW - Chlorides KW - 0 KW - Gold Compounds KW - Inflammation Mediators KW - RNA, Messenger KW - Polyethylene Glycols KW - 30IQX730WE KW - gold tetrachloride, acid KW - 8H372EGX3V KW - Index Medicus KW - Acute Disease KW - Animals KW - Neutrophil Infiltration -- drug effects KW - RNA, Messenger -- metabolism KW - Injections, Intravenous KW - Particle Size KW - Apoptosis -- drug effects KW - Mice KW - Tissue Distribution KW - Mice, Inbred BALB C KW - Male KW - Inflammation Mediators -- metabolism KW - Chlorides -- toxicity KW - Chemical and Drug Induced Liver Injury -- pathology KW - Spleen -- metabolism KW - Liver -- immunology KW - Liver -- metabolism KW - Chlorides -- pharmacokinetics KW - Chemical and Drug Induced Liver Injury -- immunology KW - Liver -- ultrastructure KW - Gold Compounds -- toxicity KW - Spleen -- ultrastructure KW - Chemical and Drug Induced Liver Injury -- etiology KW - Gold Compounds -- pharmacokinetics KW - Chlorides -- administration & dosage KW - Gold Compounds -- administration & dosage KW - Polyethylene Glycols -- chemistry KW - Liver -- drug effects KW - Spleen -- drug effects KW - Metal Nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67045150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Acute+toxicity+and+pharmacokinetics+of+13+nm-sized+PEG-coated+gold+nanoparticles.&rft.au=Cho%2C+Wan-Seob%3BCho%2C+Minjung%3BJeong%2C+Jinyoung%3BChoi%2C+Mina%3BCho%2C+Hea-Young%3BHan%2C+Beom+Seok%3BKim%2C+Sheen+Hee%3BKim%2C+Hyoung+Ook%3BLim%2C+Yong+Taik%3BChung%2C+Bong+Hyun%3BJeong%2C+Jayoung&rft.aulast=Cho&rft.aufirst=Wan-Seob&rft.date=2009-04-01&rft.volume=236&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2008.12.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-30 N1 - Date created - 2009-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2008.12.023 ER - TY - JOUR T1 - Multiresidue method for the triphenylmethane dyes in fish: Malachite green, crystal (gentian) violet, and brilliant green. AN - 67027401; 19286041 AB - Liquid chromatographic methods are presented for the quantitative and confirmatory determination of crystal violet (CV; also known as gentian violet), leucocrystal violet (LCV), brilliant green (BG), and leucobrilliant green (LBG) in catfish. LCV and LBG were oxidized to the chromic CV and BG by reaction with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, and residues were measured as the combined CV+/-LCV and BG+/-LBG. These methods are extensions of published methods for malachite green (MG) analysis to allow simultaneous determination of MG, CV, and BG. Residues were extracted from muscle with ammonium acetate buffer and acetonitrile, and extracts cleaned up using dichloromethane partitioning and solid-phase extraction. Extracts were analyzed by liquid chromatography with visible detection (LC-VIS). The method was validated for catfish fortified with LCV over the range 0.25-10 ngg(-1) and CV at 2 ngg(-1). Average recoveries were 90.6% (+/-8.1% R.S.D., n=45) for LCV and 84.4% (+/-4.2% R.S.D., n=6) for CV. The average recovery for samples fortified with BG or LBG over the range 0.5-10 ngg(-1) was 67.2% (+/-14.8% R.S.D., n=31). CV and BG were confirmed in fish extracts by ion trap LC-mass spectrometry (LC-MS(n)) with no discharge-atmospheric pressure chemical ionization. Average LC-MS(n) recoveries were 96.5, 96.6, and 70.2% for samples fortified with CV, LCV, and BG or LBG. The limits of detection for CV, BG, and MG were in the range of 0.07-0.24 ngg(-1) (ppb) for the two different instrumental methods. This methodology was applied to the analysis of catfish treated with CV and BG. JF - Analytica chimica acta AU - Andersen, Wendy C AU - Turnipseed, Sherri B AU - Karbiwnyk, Christine M AU - Lee, Rebecca H AU - Clark, Susan B AU - Rowe, W Douglas AU - Madson, Mark R AU - Miller, Keith E AD - Animal Drugs Research Center, U.S. Food and Drug Administration, Denver Federal Center, P.O. Box 25087, Denver, CO 80225-0087, USA. Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 279 EP - 289 VL - 637 IS - 1-2 KW - Anti-Infective Agents KW - 0 KW - Quaternary Ammonium Compounds KW - Rosaniline Dyes KW - Trityl Compounds KW - leucocrystal violet KW - malachite green KW - 12058M7ORO KW - brilliant green KW - G0L543D370 KW - Gentian Violet KW - J4Z741D6O5 KW - Index Medicus KW - Animals KW - Quaternary Ammonium Compounds -- analysis KW - Muscles -- chemistry KW - Catfishes KW - Quaternary Ammonium Compounds -- isolation & purification KW - Rosaniline Dyes -- isolation & purification KW - Gentian Violet -- analysis KW - Solid Phase Extraction KW - Rosaniline Dyes -- analysis KW - Gentian Violet -- isolation & purification KW - Chromatography, Liquid -- methods KW - Anti-Infective Agents -- analysis KW - Drug Residues -- analysis KW - Anti-Infective Agents -- isolation & purification KW - Trityl Compounds -- analysis KW - Fishes KW - Trityl Compounds -- isolation & purification KW - Spectrometry, Mass, Electrospray Ionization -- methods KW - Drug Residues -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67027401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+chimica+acta&rft.atitle=Multiresidue+method+for+the+triphenylmethane+dyes+in+fish%3A+Malachite+green%2C+crystal+%28gentian%29+violet%2C+and+brilliant+green.&rft.au=Andersen%2C+Wendy+C%3BTurnipseed%2C+Sherri+B%3BKarbiwnyk%2C+Christine+M%3BLee%2C+Rebecca+H%3BClark%2C+Susan+B%3BRowe%2C+W+Douglas%3BMadson%2C+Mark+R%3BMiller%2C+Keith+E&rft.aulast=Andersen&rft.aufirst=Wendy&rft.date=2009-04-01&rft.volume=637&rft.issue=1-2&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Analytica+chimica+acta&rft.issn=1873-4324&rft_id=info:doi/10.1016%2Fj.aca.2008.09.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-12 N1 - Date created - 2009-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.aca.2008.09.041 ER - TY - JOUR T1 - A method to rank order water soluble compounds according to their toxicity using Caenorhabditis elegans, a Complex Object Parametric Analyzer and Sorter, and axenic liquid media. AN - 66983273; 19162123 AB - Complex Object Parametric Analyzer and Sorter (COPAS) parameters Time of Flight (TOF) and Extinction (EXT) were utilized to assess growth and development in Caenorhabditis elegans exposed to (in order of decreasing toxicity) sodium arsenite, sodium fluoride, caffeine, valproic acid, sodium borate or DMSO in C. elegans Habitation Medium (CeHM) for 72h. Using multivariate statistical modeling and unique sub sampling procedures mean p-value ratios were calculated for each compound. Comparison of mean p-value ratios and/or the percent change in mean-p value ratios to controls were utilized to assess test compound toxicity. Using this assay 5 of the 6 compounds tested (83.3%) were correctly ranked according to their toxicity based on oral rat LD50 data. Test compounds were ranked from most toxic to least toxic as follows: sodium arsenite, sodium fluoride, sodium borate, valproic acid, caffeine and DMSO. Sodium borate was found to be more toxic than caffeine and valproic acid in this bioassay. This study suggests that axenic liquid culture may be used to expose large numbers of nematodes to water soluble toxicants and the COPAS parameters TOF and EXT may be used as functional biomarkers to assess a toxin's effect on growth and development in C. elegans. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Sprando, Robert L AU - Olejnik, Nicholas AU - Cinar, Hediye Nese AU - Ferguson, Martine AD - Division of Toxicology, United States Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Laural, MD 20708, United States. Robert.sprando@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 722 EP - 728 VL - 47 IS - 4 KW - Index Medicus KW - Animals KW - Solubility KW - Hydrogen-Ion Concentration KW - Lethal Dose 50 KW - Models, Statistical KW - Caenorhabditis elegans -- growth & development KW - Caenorhabditis elegans -- drug effects KW - Toxicity Tests -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66983273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=A+method+to+rank+order+water+soluble+compounds+according+to+their+toxicity+using+Caenorhabditis+elegans%2C+a+Complex+Object+Parametric+Analyzer+and+Sorter%2C+and+axenic+liquid+media.&rft.au=Sprando%2C+Robert+L%3BOlejnik%2C+Nicholas%3BCinar%2C+Hediye+Nese%3BFerguson%2C+Martine&rft.aulast=Sprando&rft.aufirst=Robert&rft.date=2009-04-01&rft.volume=47&rft.issue=4&rft.spage=722&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2009.01.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-02 N1 - Date created - 2009-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2009.01.007 ER - TY - JOUR T1 - The National Nursing Assistant Survey: Improving the Evidence Base for Policy Initiatives to Strengthen the Certified Nursing Assistant Workforce AN - 61413832; 200906484 AB - Purpose: This study introduces the first National Nursing Assistant Survey (NNAS), a major advance in the data available about certified nursing assistants (CNAs) and a rich resource for evidence-based policy, practice, and applied research initiatives. We highlight potential uses of this new survey using select population estimates as examples of how the NNAS can be used to inform new policy directions. Design and Methods: The NNAS is a nationally representative survey of 3,017 CNAs working in nursing homes, who were interviewed by phone in 20042005. Key survey components are recruitment; education; training and licensure; job history; family life; management and supervision; client relations; organizational commitment and job satisfaction; workplace environment; work-related injuries; and demographics. Results: One in three CNAs received some kind of means-tested public assistance. More than half of CNAs incurred at least 1 work-related injury within the past year and almost one quarter were unable to work for at least 1 day due to the injury. Forty-two percent of uninsured CNAs cite not participating in their employer-sponsored insurance plan because they could not afford the plan. Years of experience do not translate into higher wages; CNAs with 10 or more years of experience averaged just $2/hr more than aides who started working in the field less than 1 year ago. Implications: This survey can be used to understand CNA workforce issues and challenges and to plan for sustainable solutions to stabilize this workforce. The NNAS can be linked to other existing data sets to examine more comprehensive and complex relationships among CNA, facility, resident, and community characteristics, thereby expanding its usefulness. Adapted from the source document. JF - The Gerontologist AU - Squillace, Marie R AU - Remsburg, Robin E AU - Harris-Kojetin, Lauren D AU - Bercovitz, Anita AU - Rosenoff, Emily AU - Han, Beth Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 185 EP - 197 PB - Gerontological Society of America, Washington DC VL - 49 IS - 2 SN - 0016-9013, 0016-9013 KW - Certified nursing assistants, Direct care workers, Long-term care workforce, Nursing homes, National Nursing Assistant Survey KW - Organizational Commitment KW - Health Professions KW - Client Relations KW - Caregivers KW - Job Satisfaction KW - Professional Training KW - Recruitment KW - Benefits KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61413832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=The+National+Nursing+Assistant+Survey%3A+Improving+the+Evidence+Base+for+Policy+Initiatives+to+Strengthen+the+Certified+Nursing+Assistant+Workforce&rft.au=Squillace%2C+Marie+R%3BRemsburg%2C+Robin+E%3BHarris-Kojetin%2C+Lauren+D%3BBercovitz%2C+Anita%3BRosenoff%2C+Emily%3BHan%2C+Beth&rft.aulast=Squillace&rft.aufirst=Marie&rft.date=2009-04-01&rft.volume=49&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/10.1093%2Fgeront%2Fgnp024 LA - English DB - Social Services Abstracts N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Health Professions; Caregivers; Recruitment; Professional Training; Organizational Commitment; Job Satisfaction; Benefits; Client Relations DO - http://dx.doi.org/10.1093/geront/gnp024 ER - TY - JOUR T1 - Informing Public Health Policy and Practice: The Strategic Management of Research Processes and Organizations AN - 59890082; 200920597 AB - Better health depends on how well federal public health organizations perform both scientifically and organizationally. The performance challenges of public health science organizations are not carbon copies of those facing public service organizations. This article examines how one federal science agency in the public health field has instituted a performance orientation over a dozen years, offering a detailed illustration of how the in-principle advantages of the 'managing for performance' approach can be realized in practice. In taking science more seriously as a basis for public policy, the new administration should not lose sight of lessons it can learn from its predecessors about managing science organizations for performance. Adapted from the source document. JF - Governance: An International Journal of Policy, Administration, and Institutions AU - Howard, John AD - Centers for Disease Control and Prevention, U.S. Department of Health and Human Services. Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 203 EP - 216 PB - Blackwell Publishers, Malden MA VL - 22 IS - 2 SN - 0952-1895, 0952-1895 KW - Management KW - Public Health KW - Government Agencies KW - Federal Government KW - Health Policy KW - Organizational Effectiveness KW - article KW - 9261: public policy/administration; public policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59890082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Governance%3A+An+International+Journal+of+Policy%2C+Administration%2C+and+Institutions&rft.atitle=Informing+Public+Health+Policy+and+Practice%3A+The+Strategic+Management+of+Research+Processes+and+Organizations&rft.au=Howard%2C+John&rft.aulast=Howard&rft.aufirst=John&rft.date=2009-04-01&rft.volume=22&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Governance%3A+An+International+Journal+of+Policy%2C+Administration%2C+and+Institutions&rft.issn=09521895&rft_id=info:doi/10.1111%2Fj.1468-0491.2009.01432.x LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2009-07-09 N1 - Number of references - 10 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Policy; Public Health; Government Agencies; Organizational Effectiveness; Management; Federal Government DO - http://dx.doi.org/10.1111/j.1468-0491.2009.01432.x ER - TY - BOOK T1 - No-nose Saddles for Preventing Genital Numbness and Sexual Dysfunction from Occupational Bicycling AN - 58825273; 2008-442374 AB - Workers who ride a bicycle as part of their job may be at risk for genital numbness or more serious sexual and/or reproductive health problems from pressure in the groin (perineum) from the traditional bicycle saddle. NIOSH has conducted studies that have demonstrated the effectiveness of no-nose bicycle saddles in reducing pressure in the groin and improving the sexual health of male bicycle patrol police officers. While most workers in jobs that involve bicycling are men, recent evidence suggests that no-nose bicycle saddles may also benefit women. Figures, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Apr 2009, 4 pp. AU - National Institute for Occupational Safety and Health Y1 - 2009/04// PY - 2009 DA - April 2009 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Social conditions and policy - Sports KW - Transportation and transportation policy - Urban transport KW - Health conditions and policy - Health and health policy KW - Economic conditions and policy - Consumers and consumption KW - Population groups, population policy, and demographics - Men KW - Administration of justice - Police and law enforcement KW - Social conditions and policy - Public safety and security KW - Risk KW - Product safety KW - Cycling KW - Men KW - Reproductive health KW - Police KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58825273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Institute+for+Occupational+Safety+and+Health&rft.aulast=National+Institute+for+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2009-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=No-nose+Saddles+for+Preventing+Genital+Numbness+and+Sexual+Dysfunction+from+Occupational+Bicycling&rft.title=No-nose+Saddles+for+Preventing+Genital+Numbness+and+Sexual+Dysfunction+from+Occupational+Bicycling&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/wp-solutions/2009-131/pdfs/2009-131.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-02-03 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2009 N1 - SuppNotes - NIOSH Publication No. 2009-131 N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - An Overview of Safety and Health for Workers in the Horse-Racing Industry AN - 58824622; 2008-442375 AB - The safety and health hazards associated with the horse-racing industry, along with a lack of adequate disability and health insurance for its workers, prompted an investigation by Congress which culminated with hearings in 2005. One of the outcomes from these Congressional hearings was a letter from the Chairman and Ranking member of the Subcommittee on Oversight and Investigations of the U.S. House of Representatives Committee on Energy and Commerce to the Department of Health and Human Services Secretary, requesting assistance from the National Institute for Occupational Safety and Health (NIOSH) in investigating the safety and health hazards in the horse-racing industry. In response to this request, NIOSH conducted a review of the available safety and health literature on thoroughbred and standardbred horse racing; conducted site visits to two racetracks in Lexington, Kentucky, Keeneland Race Course and the North American Racing Academy; completed a fatality investigation; conducted analyses of injury data from relevant data sources; reviewed regulations governing the horse-racing industry in the United States and other countries; and held a public meeting in order to garner concerns about the health and safety of workers in the horse-racing industry. This document is intended for all workers associated with the horse-racing industry, including jockeys, other race track workers, horse and race track owners, and racing commissions. The document summarizes NIOSH's efforts in responding to the Congressional inquiry and provides recommendations for reducing the number of injuries and adverse health effects for workers in the horse-racing industry. Tables, Figures, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Apr 2009, 28 pp. AU - National Institute for Occupational Safety and Health Y1 - 2009/04// PY - 2009 DA - April 2009 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Animals KW - Social conditions and policy - Sports KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - Social conditions and policy - Public safety and security KW - Law and ethics - Criminal law KW - Government - Internal security KW - United States Congress KW - Lexington, Kentucky KW - Safety measures KW - Health insurance KW - Horses KW - Surveillance KW - Working conditions KW - Professional sports KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58824622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Institute+for+Occupational+Safety+and+Health&rft.aulast=National+Institute+for+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2009-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=An+Overview+of+Safety+and+Health+for+Workers+in+the+Horse-Racing+Industry&rft.title=An+Overview+of+Safety+and+Health+for+Workers+in+the+Horse-Racing+Industry&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2009-128/pdfs/2009-128.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-02-03 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2009 N1 - SuppNotes - NIOSH Publication No. 2009-128 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - The familial aggregation of cannabis use disorders AN - 57282189; 200909855 AB - Aims The aim of this paper is to examine the familial aggregation of cannabis use disorders and other psychiatric conditions among first-degree relatives and spouses of probands with a cannabis use disorder. Design Controlled family study methods. Setting Out-patient psychiatric clinics and the local community (same geographic area). Participants Two hundred and sixty-two probands with a life-time history of cannabis use disorder, alcohol dependence, anxiety disorders or no history of any disorder, and their first-degree relatives and spouses. Measurements Cannabis use disorders and other DSM-III-R disorders in the relatives and spouses using the Schedule for Affective Disorders and Schizophrenia. Findings Results reveal an elevated risk of life-time history of cannabis use disorders among siblings [odds ratio (OR: 3.6), adult offspring (OR): 6.9], and spouses (OR: 4.4) of probands with cannabis use disorders. There is a latent familial factor underlying cannabis use disorders that was shared partially with alcohol abuse/dependence. Comorbid mood and anxiety disorders aggregated independently from cannabis use disorders in families. Equal elevation in the magnitude of the association among the first-degree adult relatives and spouses of probands with a cannabis use disorder suggests the probable contribution of both environmental and genetic factors. Conclusions These findings support a family-based approach to drug abuse intervention and the importance of future research concerning environmental mediators of familial transmission of drug abuse. Submitted 17 January 2008; initial review completed 29 April 2008; final version accepted 14 October 2008. Adapted from the source document. JF - Addiction AU - Merikangas, Kathleen R AU - Li, Julan Julia AU - Stipelman, Brooke AU - Yu, Kelly AU - Fucito, Lisa AU - Swendsen, Joel AU - Zhang, Heping AD - Section on Developmental Genetic Epidemiology, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA kathleen.merikangas@nih.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 622 EP - 629 PB - Blackwell Publishing, Oxford UK VL - 104 IS - 4 SN - 0965-2140, 0965-2140 KW - Alcohol dependence KW - Substance abuse disorders KW - Cannabis KW - Aggregation KW - Relatives KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57282189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=The+familial+aggregation+of+cannabis+use+disorders&rft.au=Merikangas%2C+Kathleen+R%3BLi%2C+Julan+Julia%3BStipelman%2C+Brooke%3BYu%2C+Kelly%3BFucito%2C+Lisa%3BSwendsen%2C+Joel%3BZhang%2C+Heping&rft.aulast=Merikangas&rft.aufirst=Kathleen&rft.date=2009-04-01&rft.volume=104&rft.issue=4&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02468.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Cannabis; Substance abuse disorders; Alcohol dependence; Relatives; Aggregation DO - http://dx.doi.org/10.1111/j.1360-0443.2008.02468.x ER - TY - JOUR T1 - Identifying sources of respirable quartz and silica dust in underground coal mines in southern West Virginia, western Virginia, and eastern Kentucky AN - 50124365; 2010-000777 AB - Prior research has suggested that the source of respirable silica dust in underground coal mines is typically the immediate top or bottom lithology adjacent to the mined seam, not mineral matter bound within the mined coal bed. Geochemical analyses were applied in an effort to identify the specific source rock of respirable quartz dust in coal mines. The analyses also demonstrate the compositional changes that take place in the generation of the respirable dust fraction from parent rock material. All six mine sites were mining coal with relatively low mineral matter content, although two mines were operating in the Fire Clay coal bed which contains a persistent tonstein. Interpretations of Ca, Mg, Mn, Na, and K concentrations strongly suggest that the top strata above the mined seam is the primary source of mineral dust produced during mining. One site indicates a mixed or bottom source, possibly due to site specific conditions. Respirable dust compositional analyses suggest a direct relationship between the quantity of mineral Si and the quantity of quartz Si. A similar relationship was not found in either the top or bottom rocks adjacent to the mined seam. An apparent loss of elemental Al was noted in the respirable dust fraction when compared to potential parent rock sources. Elemental Al is present in top and bottom rock strata within illite, kaolinite, feldspar, and chlorite. A possible explanation for loss of Al in the respirable dust samples is the removal of clays and possibly chlorite minerals. It is expected that removal of this portion of the Al bearing mineral matter occurs during rock abrasion and dust transport prior to dust capture on the samplers. JF - International Journal of Coal Geology AU - Schatzel, Steven J Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 110 EP - 118 PB - Elsevier, Amsterdam VL - 78 IS - 2 SN - 0166-5162, 0166-5162 KW - United States KW - silicates KW - silica minerals KW - coal seams KW - sedimentary rocks KW - mineral composition KW - coal KW - sediments KW - framework silicates KW - chlorite group KW - geochemistry KW - West Virginia KW - fireclay KW - mines KW - clastic sediments KW - coal mines KW - kaolinite KW - illite KW - clay minerals KW - chlorite KW - safety KW - dust KW - tonstein KW - quartz KW - sheet silicates KW - feldspar group KW - clastic rocks KW - public health KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50124365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Identifying+sources+of+respirable+quartz+and+silica+dust+in+underground+coal+mines+in+southern+West+Virginia%2C+western+Virginia%2C+and+eastern+Kentucky&rft.au=Schatzel%2C+Steven+J&rft.aulast=Schatzel&rft.aufirst=Steven&rft.date=2009-04-01&rft.volume=78&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2009.01.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - chlorite; chlorite group; clastic rocks; clastic sediments; clay minerals; coal; coal mines; coal seams; dust; feldspar group; fireclay; framework silicates; geochemistry; illite; kaolinite; mineral composition; mines; public health; quartz; safety; sedimentary rocks; sediments; sheet silicates; silica minerals; silicates; tonstein; United States; West Virginia DO - http://dx.doi.org/10.1016/j.coal.2009.01.003 ER - TY - JOUR T1 - Model-averaged benchmark concentration estimates for continuous response data arising from epidemiological studies AN - 37280950; 3940584 AB - Worker populations often provide data on adverse responses associated with exposure to potential hazards. The relationship between hazard exposure levels and adverse response can be modeled and then inverted to estimate the exposure associated with some specified response level. One concern is that this endpoint may be sensitive to the concentration metric and other variables included in the model. Further, it may be that the models yielding different risk endpoints are all providing relatively similar fits. We focus on evaluating the impact of exposure on a continuous response by constructing a model-averaged benchmark concentration from a weighted average of model-specific benchmark concentrations. A method for combining the estimates based on different models is applied to lung function in a cohort of miners exposed to coal dust. In this analysis, we see that a small number of the thousands of models considered survive a filtering criterion for use in averaging. Even after filtering, the models considered yield benchmark concentrations that differ by a factor of 2 to 9 depending on the concentration metric and covariates. The model-average BMC captures this uncertainty, and provides a useful strategy for addressing model uncertainty. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Noble, Robert B AU - Bailer, A John AU - Park, Robert AD - Miami University ; National Institute for Occupational Safety and Health, USA Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 558 EP - 564 VL - 29 IS - 4 SN - 0272-4332, 0272-4332 KW - Economics KW - Probability KW - Risk KW - Epidemiology KW - Occupational safety KW - Regression analysis KW - Modelling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37280950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=Model-averaged+benchmark+concentration+estimates+for+continuous+response+data+arising+from+epidemiological+studies&rft.au=Noble%2C+Robert+B%3BBailer%2C+A+John%3BPark%2C+Robert&rft.aulast=Noble&rft.aufirst=Robert&rft.date=2009-04-01&rft.volume=29&rft.issue=4&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2008.01178.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 8856 11229; 4357 7894; 11035; 8162 8163; 10739 12228 10919; 10214 12224 971 DO - http://dx.doi.org/10.1111/j.1539-6924.2008.01178.x ER - TY - JOUR T1 - Evidence for substance abuse services and policy research: a systematic review of national databases AN - 37104847; 3851964 AB - We reviewed 39 national government- and nongovernment-sponsored data sets related to substance addiction policy. These data sets describe patients with substance use disorders (SUDs), treatment providers and the services they offer, and/or expenditures on treatment. Findings indicate the availability of reliable data on the prevalence of SUD and the characteristics of specialty treatment facilities, but meager data on financing and services. Gaps in information might be filled through agency collaboration to redesign, coordinate, and augment existing substance abuse and general health surveys. Despite noted gaps, these data sets represent an unusually rich set of resources for health services and policy research. Reprinted by permission of Sage Publications, Inc. JF - Evaluation review AU - Coffey, Rosanna AU - Levit, Katharine AU - Kassed, Cheryl AU - McLellan, A AU - Chalk, Mady AU - Brady, Thomas AU - Vandivort-Warren, Rita AD - Thomson Reuters ; Treatment Research Institute ; National Institute on Drug Abuse ; Substance Abuse and Mental Health Services Administration Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 103 EP - 137 VL - 33 IS - 2 SN - 0193-841X, 0193-841X KW - Sociology KW - Financing methods KW - Medical treatment KW - Data analysis KW - Drug addiction KW - Drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37104847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation+review&rft.atitle=Evidence+for+substance+abuse+services+and+policy+research%3A+a+systematic+review+of+national+databases&rft.au=Coffey%2C+Rosanna%3BLevit%2C+Katharine%3BKassed%2C+Cheryl%3BMcLellan%2C+A%3BChalk%2C+Mady%3BBrady%2C+Thomas%3BVandivort-Warren%2C+Rita&rft.aulast=Coffey&rft.aufirst=Rosanna&rft.date=2009-04-01&rft.volume=33&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Evaluation+review&rft.issn=0193841X&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7890 5792 10484; 3742 1121 11776 3753 3755; 3744 561 6220; 3279 971 3286; 4968 4908 ER - TY - JOUR T1 - Anthrax Protective Antigen Delivered by Salmonella enterica Serovar Typhi Ty21a Protects Mice from a Lethal Anthrax Spore Challenge , AN - 21495617; 12511132 AB - Bacillus anthracis, the etiological agent of anthrax disease, is a proven weapon of bioterrorism. Currently, the only licensed vaccine against anthrax in the United States is AVA Biothrax, which, although efficacious, suffers from several limitations. This vaccine requires six injectable doses over 18 months to stimulate protective immunity, requires a cold chain for storage, and in many cases has been associated with adverse effects. In this study, we modified the B. anthracis protective antigen (PA) gene for optimal expression and stability, linked it to an inducible promoter for maximal expression in the host, and fused it to the secretion signal of the Escherichia coli alpha-hemolysin protein (HlyA) on a low-copy-number plasmid. This plasmid was introduced into the licensed typhoid vaccine strain, Salmonella enterica serovar Typhi strain Ty21a, and was found to be genetically stable. Immunization of mice with three vaccine doses elicited a strong PA-specific serum immunoglobulin G response with a geometric mean titer of 30,000 (range, 5,800 to 157,000) and lethal-toxin-neutralizing titers greater than 16,000. Vaccinated mice demonstrated 100% protection against a lethal intranasal challenge with aerosolized spores of B. anthracis 7702. The ultimate goal is a temperature-stable, safe, oral human vaccine against anthrax infection that can be self-administered in a few doses over a short period of time. JF - Infection and Immunity AU - Osorio, Manuel AU - Wu, Yanping AU - Singh, Sunil AU - Merkel, Tod J AU - Bhattacharyya, Siba AU - Blake, Milan S AU - Kopecko, Dennis J AD - Laboratory of Enteric and Sexually Transmitted Diseases, manuel.osorio@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1475 EP - 1482 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 4 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Anthrax KW - Immunity KW - Immunization KW - Immunoglobulin G KW - Infection KW - Plasmids KW - Promoters KW - Side effects KW - Spores KW - Vaccination KW - Vaccines KW - bioterrorism KW - protective antigen KW - secretion signals KW - Bacillus anthracis KW - Salmonella enterica KW - Escherichia coli KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21495617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Anthrax+Protective+Antigen+Delivered+by+Salmonella+enterica+Serovar+Typhi+Ty21a+Protects+Mice+from+a+Lethal+Anthrax+Spore+Challenge+%2C&rft.au=Osorio%2C+Manuel%3BWu%2C+Yanping%3BSingh%2C+Sunil%3BMerkel%2C+Tod+J%3BBhattacharyya%2C+Siba%3BBlake%2C+Milan+S%3BKopecko%2C+Dennis+J&rft.aulast=Osorio&rft.aufirst=Manuel&rft.date=2009-04-01&rft.volume=77&rft.issue=4&rft.spage=1475&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00828-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - bioterrorism; protective antigen; Immunity; Plasmids; Infection; Vaccination; Immunization; Promoters; secretion signals; Immunoglobulin G; Anthrax; Vaccines; Spores; Side effects; Salmonella enterica; Escherichia coli; Bacillus anthracis DO - http://dx.doi.org/10.1128/IAI.00828-08 ER - TY - JOUR T1 - HtaA Is an Iron-Regulated Hemin Binding Protein Involved in the Utilization of Heme Iron in Corynebacterium diphtheriae AN - 21307638; 11916535 AB - Many human pathogens, including Corynebacterium diphtheriae, the causative agent of diphtheria, use host compounds such as heme and hemoglobin as essential iron sources. In this study, we examined the Corynebacterium hmu hemin transport region, a genetic cluster that contains the hmuTUV genes encoding a previously described ABC-type hemin transporter and three additional genes, which we have designated htaA, htaB, and htaC. The hmu gene cluster is composed of three distinct transcriptional units. The htaA gene appears to be part of an iron- and DtxR-regulated operon that includes hmuTUV, while htaB and htaC are transcribed from unique DtxR-regulated promoters. Nonpolar deletion of either htaA or the hmuTUV genes resulted in a reduced ability to use hemin as an iron source, while deletion of htaB had no effect on hemin iron utilization in C. diphtheriae. A comparison of the predicted amino acid sequences of HtaA and HtaB showed that they share some sequence similarity, and both proteins contain leader sequences and putative C-terminal transmembrane regions. Protein localization studies with C. diphtheriae showed that HtaA is associated predominantly with the cell envelope when the organism is grown in minimal medium but is secreted during growth in nutrient-rich broth. HtaB and HmuT were detected primarily in the cytoplasmic membrane fraction regardless of the growth medium. Hemin binding studies demonstrated that HtaA and HtaB are able to bind hemin, suggesting that these proteins may function as cell surface hemin receptors in C. diphtheriae. JF - Journal of Bacteriology AU - Allen, Courtni E AU - Schmitt, Michael P AD - Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, michael.schmitt@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 2638 EP - 2648 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 8 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Cell surface KW - Receptor mechanisms KW - Heme KW - Cell envelopes KW - Transcription KW - Corynebacterium diphtheriae KW - Hemin KW - Diphtheria KW - Pathogens KW - Corynebacterium KW - Hemoglobin KW - Promoters KW - Cytoplasmic membranes KW - Operons KW - Iron KW - Amino acid sequence KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21307638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=HtaA+Is+an+Iron-Regulated+Hemin+Binding+Protein+Involved+in+the+Utilization+of+Heme+Iron+in+Corynebacterium+diphtheriae&rft.au=Allen%2C+Courtni+E%3BSchmitt%2C+Michael+P&rft.aulast=Allen&rft.aufirst=Courtni&rft.date=2009-04-01&rft.volume=191&rft.issue=8&rft.spage=2638&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01784-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 50 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Cell surface; Heme; Receptor mechanisms; Cell envelopes; Transcription; Hemin; Pathogens; Diphtheria; Hemoglobin; Promoters; Cytoplasmic membranes; Operons; Iron; Amino acid sequence; Corynebacterium diphtheriae; Corynebacterium DO - http://dx.doi.org/10.1128/JB.01784-08 ER - TY - JOUR T1 - Comparison of the synthetic biodegradable polymers, polylactide (PLA), and polylactic-co-glycolic acid (PLGA) as scaffolds for artificial cartilage AN - 21232287; 11798713 AB - Chondrocytes are easily de-differentiated when cultured in monolayer, and tissue-engineered cartilage can be generated by seeding chondrocytes onto three-dimensional porous synthetic biodegradable polymers. In this study, we investigated the biochemical and molecular aspects of chondrocytes in a monolayer-culture system and selected the optimal subculture passages based on their de-differentiation. We also compared two commonly used synthetic biodegradable polymers, polylactide (PLA), and polylactic-co-glycolic acid (PLGA), for their suitability as scaffolds for artificial cartilage. De-differentiated chondrocytes were observed after two passages. These results suggested that the first cell passage was optimal for seeding as only a few chondrocytes secreted extracellular matrix components to form homogeneously compact cartilage. Substantially increased glycosaminoglycan and total collagen levels revealed that PLGA scaffolds were a better option for inducing cartilage tissue formation compared to the PLA scaffolds. Histological and immunohistochemical results showed that chondrocytes seeded into PLGA retained their morphological phenotype to a greater extent than those seeded into PLA. JF - Biotechnology and Bioprocess Engineering AU - Lee, Nam Kyoung AU - Oh, Ho Jung AU - Hong, Choong Man AU - Suh, Hwal AU - Hong, Seung Hwa AD - Biologics Bureau, Korea Food and Drug Administration, Seoul, 122-704, Korea Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 180 EP - 186 PB - Korean Society for Biotechnology and Bioengineering VL - 14 IS - 2 SN - 1226-8372, 1226-8372 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Glycosaminoglycans KW - Cartilage KW - polylactide-co-glycolide KW - Extracellular matrix KW - Chondrocytes KW - polylactide KW - Subculture KW - Tissue engineering KW - scaffolds KW - Collagen KW - W 30910:Imaging KW - T 2030:Cartilage and Cartilage Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21232287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioprocess+Engineering&rft.atitle=Comparison+of+the+synthetic+biodegradable+polymers%2C+polylactide+%28PLA%29%2C+and+polylactic-co-glycolic+acid+%28PLGA%29+as+scaffolds+for+artificial+cartilage&rft.au=Lee%2C+Nam+Kyoung%3BOh%2C+Ho+Jung%3BHong%2C+Choong+Man%3BSuh%2C+Hwal%3BHong%2C+Seung+Hwa&rft.aulast=Lee&rft.aufirst=Nam&rft.date=2009-04-01&rft.volume=14&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioprocess+Engineering&rft.issn=12268372&rft_id=info:doi/10.1007%2Fs12257-008-0208-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Glycosaminoglycans; Extracellular matrix; polylactide-co-glycolide; Cartilage; Subculture; polylactide; Chondrocytes; Tissue engineering; scaffolds; Collagen DO - http://dx.doi.org/10.1007/s12257-008-0208-z ER - TY - JOUR T1 - Lymphotoxin-a and TNF Have Essential but Independent Roles in the Evolution of the Granulomatous Response in Experimental Leprosy AN - 21196214; 11664381 AB - Recent studies identified an association between genetic variants in the lymphotoxin-a (LTa) gene and leprosy. To study the influence of LTa on the control of experimental leprosy, both low- and high-dose Mycobacterium leprae foot pad (FP) infections were evaluated in LT a-deficient chimeric (cLTa super(-/-)) and control chimeric (cB6) mice. Cellular responses to low-dose infection in cLTa super(-/-) mice were dramatically different, with reduced accumulation of CD4 super(+) and CD8 super(+) lymphocytes and macrophages and failure to form granulomas. Growth of M. leprae was contained for 6 months, but augmented late in infection. In contrast, tumor necrosis factor knockout and tumor necrosis factor receptor 1 knockout FPs exhibited extensive inflammatory infiltration with an increase in M. leprae growth throughout infection. Following high-dose infection, cB6 FP induration peaked at 4 weeks and was maintained for 12 weeks. Induration was not sustained in cLTa super(-/-) FPs that contained few lymphocytes and no granulomas. There was a reduction in the expression levels of inflammatory cytokines, chemokines, and chemokine receptors, including nitric oxide synthase 2, vascular cell adhesion molecule, and intercellular cell adhesion molecule. Furhermore, cLTa super(-/-) popliteal lymph nodes contained a higher proportion of naive CD44 super(lo)CD62L super(hi) T cells than cB6 mice, suggestive of reduced T cell activation. Therefore, both LTa and tumor necrosis factor are essential for the regulation of the granuloma, but they have distinctive roles in the recruitment of lymphocytes and maintenance of the granulomatous response during chronic M. leprae infection. JF - American Journal of Pathology AU - Hagge, DA AU - Saunders, B M AU - Ebenezer, G J AU - Ray, NA AU - Marks, V T AU - Britton, W J AU - Krahenbuhl, J L AU - Adams, L B AD - Department of Health and Human Services, Health Resources Services Administration, Bureau of Primary Health Care, National Hansen's Disease Programs, Baton Rouge, Louisiana, USA Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1379 EP - 1389 VL - 174 IS - 4 SN - 0002-9440, 0002-9440 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Mycobacterium leprae KW - Tumor necrosis factor KW - Chemokine receptors KW - CD8 antigen KW - Granuloma KW - Lymph nodes KW - Cell activation KW - Inflammation KW - Leprosy KW - tumor necrosis factor receptor 1 KW - Nitric-oxide synthase KW - Metastases KW - CD4 antigen KW - Chronic infection KW - Foot KW - Lymphocytes T KW - Cytokines KW - Lymphotoxin KW - Cell adhesion molecules KW - Evolution KW - Vascular system KW - J 02320:Cell Biology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21196214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Pathology&rft.atitle=Lymphotoxin-a+and+TNF+Have+Essential+but+Independent+Roles+in+the+Evolution+of+the+Granulomatous+Response+in+Experimental+Leprosy&rft.au=Hagge%2C+DA%3BSaunders%2C+B+M%3BEbenezer%2C+G+J%3BRay%2C+NA%3BMarks%2C+V+T%3BBritton%2C+W+J%3BKrahenbuhl%2C+J+L%3BAdams%2C+L+B&rft.aulast=Hagge&rft.aufirst=DA&rft.date=2009-04-01&rft.volume=174&rft.issue=4&rft.spage=1379&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Pathology&rft.issn=00029440&rft_id=info:doi/10.2353%2Fajpath.2009.080550 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Macrophages; Tumor necrosis factor; Chemokine receptors; CD8 antigen; Granuloma; Lymph nodes; tumor necrosis factor receptor 1; Leprosy; Inflammation; Cell activation; Metastases; Nitric-oxide synthase; CD4 antigen; Chronic infection; Lymphocytes T; Foot; Lymphotoxin; Cytokines; Evolution; Cell adhesion molecules; Vascular system; Mycobacterium leprae DO - http://dx.doi.org/10.2353/ajpath.2009.080550 ER - TY - JOUR T1 - Challenges and regulatory experiences with non-inferiority trial design without placebo arm AN - 21124951; 11158298 AB - For a non-inferiority trial without a placebo arm, the direct comparison between the test treatment and the selected positive control is in principle the only basis for statistical inference. Therefore, evaluating the test treatment relative to the non-existent placebo presents extreme challenges and requires some kind of bridging from the past to the present with no current placebo data. For such inference based partly on an indirect bridging manipulation, fixed margin method and synthesis method are the two widely discussed methods in the recent literature. There are major differences in statistical inference paradigm between the two methods. The fixed margin method employs the historical data that assess the performances of the active control versus a placebo to guide the selection of the non-inferiority margin. Such guidance is not part of the ultimate statistical inference in the non-inferiority trial. In contrast, the synthesis method connects the historical data to the non-inferiority trial data for making broader inferences relating the test treatment to the non-existent current placebo. On the other hand, the type I error rate associated with the direct comparison between the test treatment and the active control cannot shed any light on the appropriateness of the indirect inference for faring the test treatment against the non-existent placebo. This work explores an approach for assessing the impact of potential bias due to violation of a key statistical assumption to guide determination of the non-inferiority margin. JF - Biometrical Journal AU - Hung, H M James AU - Wang, Sue-Jane AU - O'Neill, Robert AD - Division of Biometrics I, OB/OTS/CDER, US FDA, 10903 New Hampshire Ave, HFD-710, Silver Spring, MD 20993-0002, USA, hsienming.hung@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 324 EP - 334 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 2 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Statistics KW - Biometrics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21124951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Challenges+and+regulatory+experiences+with+non-inferiority+trial+design+without+placebo+arm&rft.au=Hung%2C+H+M+James%3BWang%2C+Sue-Jane%3BO%27Neill%2C+Robert&rft.aulast=Hung&rft.aufirst=H+M&rft.date=2009-04-01&rft.volume=51&rft.issue=2&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200800219 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Statistics; Data processing; Biometrics DO - http://dx.doi.org/10.1002/bimj.200800219 ER - TY - JOUR T1 - Adaptive patient enrichment designs in therapeutic trials AN - 21100365; 11133108 AB - The utility of clinical trial designs with adaptive patient enrichment is investigated in an adequate and well-controlled trial setting. The overall treatment effect is the weighted average of the treatment effects in the mutually exclusive subsets of the originally intended entire study population. The adaptive enrichment approaches permit assessment of treatment effect that may be applicable to specific nested patient (sub)sets due to heterogeneous patient characteristics and/or differential response to treatment, e.g. a responsive patient subset versus a lack of beneficial patient subset, in all patient (sub)sets studied. The adaptive enrichment approaches considered include three adaptive design scenarios: (i) total sample size fixed and with futility stopping, (ii) sample size adaptation and futility stopping, and (iii) sample size adaptation without futility stopping. We show that regardless of whether the treatment effect eventually assessed is applicable to the originally studied patient population or only to the nested patient subsets; it is possible to devise an adaptive enrichment approach that statistically outperforms one-size-fits-all fixed design approach and the fixed design with a pre-specified multiple test procedure. We emphasize the need of additional studies to replicate the finding of a treatment effect in an enriched patient subset. The replication studies are likely to need fewer number of patients because of an identified treatment effect size that is larger than the diluted overall effect size. The adaptive designs, when applicable, are along the line of efficiency consideration in a drug development program. JF - Biometrical Journal AU - Wang, Sue-Jane AU - Hung, H M James AU - O'Neill, Robert T AD - Office of Biostatistics, Division of Biometrics I/OB, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, USA, suejane.wang@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 358 EP - 374 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 2 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Adaptations KW - Replication KW - Population studies KW - Drug development KW - Clinical trials KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21100365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Adaptive+patient+enrichment+designs+in+therapeutic+trials&rft.au=Wang%2C+Sue-Jane%3BHung%2C+H+M+James%3BO%27Neill%2C+Robert+T&rft.aulast=Wang&rft.aufirst=Sue-Jane&rft.date=2009-04-01&rft.volume=51&rft.issue=2&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200900003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Clinical trials; Adaptations; Drug development; Population studies; Replication DO - http://dx.doi.org/10.1002/bimj.200900003 ER - TY - JOUR T1 - Transmission of Different Strains of Plasmodium cynomolgi to Aotus nancymaae Monkeys and Relapse AN - 21091415; 11206670 AB - Forty-four splenectomized Aotus nancymaae monkeys were infected with 6 different strains of Plasmodium cynomolgi, 11 via trophozoites and 33 via sporozoites. Sporozoites from Anopheles dirus, Anopheles freeborni, Anopheles gambiae, Anopheles maculatus, and Anopheles stephensi resulted in prepatent periods ranging from 9 to 39 days (median of 15 days). Importantly, relapse was demonstrated in 5 of 5 sporozoite-induced infections with the Rossan strain following treatment with chloroquine. JF - Journal of Parasitology AU - Collins, William E AU - Sullivan, Jo Ann S AU - Nace, Douglas AU - Williams, Tyrone AU - Williams, Allison AU - Barnwell, John W AD - Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, and Animal Resources Branch, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, U.S. Public Health Service, Department of Health and Human Services, Atlanta, Georgia 30341., wec1@cdc.gov Y1 - 2009/04// PY - 2009 DA - April 2009 SP - 349 EP - 352 PB - American Society of Parasitologists VL - 95 IS - 2 SN - 0022-3395, 0022-3395 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; Entomology Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Aotus KW - Anopheles stephensi KW - Disease control KW - Sporozoites KW - Chloroquine KW - Infection KW - Anopheles gambiae KW - Anopheles freeborni KW - Plasmodium cynomolgi KW - Anopheles dirus KW - Anopheles maculatus KW - Aquatic insects KW - Trophozoites KW - K 03410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21091415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Parasitology&rft.atitle=Transmission+of+Different+Strains+of+Plasmodium+cynomolgi+to+Aotus+nancymaae+Monkeys+and+Relapse&rft.au=Collins%2C+William+E%3BSullivan%2C+Jo+Ann+S%3BNace%2C+Douglas%3BWilliams%2C+Tyrone%3BWilliams%2C+Allison%3BBarnwell%2C+John+W&rft.aulast=Collins&rft.aufirst=William&rft.date=2009-04-01&rft.volume=95&rft.issue=2&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Journal+of+Parasitology&rft.issn=00223395&rft_id=info:doi/10.1645%2FGE-1797.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Disease control; Aquatic insects; Chloroquine; Sporozoites; Infection; Trophozoites; Aotus; Anopheles freeborni; Plasmodium cynomolgi; Anopheles stephensi; Anopheles dirus; Anopheles maculatus; Anopheles gambiae DO - http://dx.doi.org/10.1645/GE-1797.1 ER - TY - RPRT T1 - Preventing Occupational Exposures to Lead and Noise at Indoor Firing Ranges AN - 20769642; 10308239 AB - Employers and firing range operators should take steps to protect their workers and shooters from exposure to hazardous lead concentrations and noise levels at indoor firing ranges. The National Institute for Occupational Safety and Health (NIOSH) requests help in preventing injury and illness in workers at indoor firing ranges in the United States. Workers are potentially exposed to hazardous amounts of lead and noise at these ranges. They include thousands of employees at the firing ranges as well as more than a million Federal, State, and local law officers who train regularly at these facilities. In addition to workers, 20 million active target shooters are potentially exposed to lead and noise hazards at indoor firing ranges. This Alert presents five case reports that document lead and noise exposures of law enforcement officers and students. The Alert examines firing range operations, exposure assessment and control methods, existing regulations, and exposure standards and guidelines. JF - Preventing Occupational Exposures to Lead and Noise at Indoor Firing Ranges. 32 pp. Apr 2009. Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 32 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Law enforcement KW - Injuries KW - Occupational safety KW - Guidelines KW - Noise levels KW - Lead KW - USA KW - guidelines KW - law enforcement KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20769642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Pollution+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-04-01&rft.volume=&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=Preventing+Occupational+Exposures+to+Lead+and+Noise+at+Indoor+Firing+Ranges&rft.title=Preventing+Occupational+Exposures+to+Lead+and+Noise+at+Indoor+Firing+Ranges&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2012-03-29 ER - TY - JOUR T1 - Improving the Environmental Controls at a Homeless Shelter to Assist in Reducing the Probability of Airborne Mycobacterium tuberculosis: A Case Study AN - 20748226; 9383946 AB - This study describes a survey of environmental controls conducted by the National Institute for Occupational Safety and Health (NIOSH) at the Salvation Army Harbor Light Center homeless shelter in the City of St. Louis, Missouri. The Missouri Department of Health and Senior Services (MO DHHS) had epidemiologically linked 19 cases of active tuberculosis (TB) to the shelter. MO DHSS requested NIOSH to determine whether improvements could be made to the environmental controls to help reduce the probability of airborne transmission of TB at the shelter. NIOSH investigators conducted thorough inspections of the shelter's air-handling units (AHUs) and evaluated airflow rates. NIOSH recommended higher efficiency filters be used in the AHUs and installation of ultraviolet lights. JF - Indoor and Built Environment AU - Coffey, C C AU - Hudnall, J B AU - Martin, SB Jr AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA, CCoffey@cdc.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 168 EP - 182 VL - 18 IS - 2 SN - 1420-326X, 1420-326X KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Air quality control KW - tuberculosis KW - USA, Missouri KW - Shelter KW - Mycobacterium tuberculosis KW - H 11000:Diseases/Injuries/Trauma KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20748226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+and+Built+Environment&rft.atitle=Improving+the+Environmental+Controls+at+a+Homeless+Shelter+to+Assist+in+Reducing+the+Probability+of+Airborne+Mycobacterium+tuberculosis%3A+A+Case+Study&rft.au=Coffey%2C+C+C%3BHudnall%2C+J+B%3BMartin%2C+SB+Jr&rft.aulast=Coffey&rft.aufirst=C&rft.date=2009-04-01&rft.volume=18&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Indoor+and+Built+Environment&rft.issn=1420326X&rft_id=info:doi/10.1177%2F1420326X09103008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Shelter; tuberculosis; Mycobacterium tuberculosis; USA, Missouri DO - http://dx.doi.org/10.1177/1420326X09103008 ER - TY - JOUR T1 - Quality Assurance and Safety of Herbal Dietary Supplements AN - 20664399; 9448558 AB - Since the U.S. Congress passed the Dietary Supplement Health and Education Act (DSHEA) in 1994, use of herbal products has been growing rapidly worldwide. To ensure consumer health protection, the quality and safety of herbal plants, particularly those used for dietary supplement preparations, must be determined. To date, toxicological data on the identification of genotoxic and tumorigenic ingredients in many raw herbs and their mechanisms of action are lacking. Thus, identification of carcinogenic components in herbal plants is timely and important. In this review, the issues of quality control and safety evaluation of raw herbs and herbal dietary supplements are discussed. Two examples of tumorigenicity and mechanism of tumor induction are discussed: aristolochic acid and riddelliine, both of which have been detected in Chinese herbal plants. It is proposed that an organized effort with international participation on cancer risk assessment should be actively pursued so that the safety of commercial herbal plants and herbal dietary supplements can be ensured. JF - Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews AU - Fu, P E T E R P AU - Chiang, H S I U- M E I AU - Xia, Q I N G S U AU - Chen, T A O AU - Chen, B A I Hsiun AU - Yin, J U E- J I E AU - Wen, K U O- C H I N G AU - Lin, G E AU - Yu, H O N G T A O AD - National Center for Toxicological Research, Jefferson, Arkansas, USA Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 91 EP - 119 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 27 IS - 2 SN - 1059-0501, 1059-0501 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Consumer products KW - herbs KW - Plant protection KW - tumors KW - Carcinogenicity KW - Herbal medicines KW - Consumers KW - Herbs KW - Data processing KW - dietary supplements KW - quality assurance KW - Congress KW - Genotoxicity KW - Tumorigenicity KW - Tumors KW - Cancer KW - USA KW - Education KW - Reviews KW - Quality control KW - Dietary supplements KW - Carcinogenesis KW - Aristolochic acid KW - H 9000:Consumer and Recreation Safety KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20664399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.atitle=Quality+Assurance+and+Safety+of+Herbal+Dietary+Supplements&rft.au=Fu%2C+P+E+T+E+R+P%3BChiang%2C+H+S+I+U-+M+E+I%3BXia%2C+Q+I+N+G+S+U%3BChen%2C+T+A+O%3BChen%2C+B+A+I+Hsiun%3BYin%2C+J+U+E-+J+I+E%3BWen%2C+K+U+O-+C+H+I+N+G%3BLin%2C+G+E%3BYu%2C+H+O+N+G+T+A+O&rft.aulast=Fu&rft.aufirst=P+E+T+E+R&rft.date=2009-04-01&rft.volume=27&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.issn=10590501&rft_id=info:doi/10.1080%2F10590500902885676 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Data processing; Plant protection; Genotoxicity; Tumorigenicity; Tumors; Cancer; Dietary supplements; Quality control; Aristolochic acid; Carcinogenesis; Herbal medicines; Consumers; Herbs; dietary supplements; Consumer products; herbs; Congress; quality assurance; tumors; Education; Carcinogenicity; Reviews; USA DO - http://dx.doi.org/10.1080/10590500902885676 ER - TY - JOUR T1 - Residual total protein and total organic carbon levels on reprocessed gastrointestinal (GI) biopsy forceps AN - 20596864; 9304328 AB - Many single-use (disposable) devices are reprocessed between patient uses. In the past, a visual determination was considered the endpoint of clean for cleaned reusable devices. In this report, we measured quantitative endpoints by measuring residual total protein and residual total organic carbon before and after cleaning with commercially available cleaners for medical devices on 15 single-use gastrointestinal biopsy forceps inoculated with a three-protein test soil before and after cleaning. Each device was extracted separately and tested using Bradford's reagent for total protein and a direct digestion method for total organic carbon. Data for pre- and post-cleaned devices were generated for all five cleaning cycles. The highest amounts of residual total protein and total organic carbon found on precleaned devices were 61.8 g/cm2 and 39.1 g/cm2, respectively, on the outer surfaces. The highest amounts of residual total protein and total organic carbon on postcleaned device extracts were 4.0 g/cm2 and 2.2 g/cm2, respectively, on the outer surfaces. All postcleaned devices were visually clean. Our results provide quantitative total protein and total organic carbon levels for cleaned single-use biopsy forceps. JF - Journal of Biomedical Materials Research Part B AU - Lappalainen, Sharon K AU - Gomatam, Shanti V AU - Hitchins, Victoria M AD - Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland 20850, victoria.hitchins@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 172 EP - 176 PB - John Wiley & Sons, Inc. VL - 89B IS - 1 SN - 1552-4973, 1552-4973 KW - Biotechnology and Bioengineering Abstracts KW - Soil KW - Digestion KW - Data processing KW - total organic carbon KW - Biopsy KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20596864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research+Part+B&rft.atitle=Residual+total+protein+and+total+organic+carbon+levels+on+reprocessed+gastrointestinal+%28GI%29+biopsy+forceps&rft.au=Lappalainen%2C+Sharon+K%3BGomatam%2C+Shanti+V%3BHitchins%2C+Victoria+M&rft.aulast=Lappalainen&rft.aufirst=Sharon&rft.date=2009-04-01&rft.volume=89B&rft.issue=1&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research+Part+B&rft.issn=15524973&rft_id=info:doi/10.1002%2Fjbm.b.31202 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Digestion; Soil; Data processing; total organic carbon; Biopsy DO - http://dx.doi.org/10.1002/jbm.b.31202 ER - TY - JOUR T1 - Detection of undeclared erectile dysfunction drugs and analogues in dietary supplements by ion mobility spectrometry AN - 20539460; 9221335 AB - An ion mobility spectrometry (IMS) method was developed to screen for the presence of undeclared synthetic erectile dysfunction (ED) drugs or drug analogues in herbal dietary supplements claiming to enhance male sexual performance. Ion mobility spectra of authenticated reference materials including three FDA approved drugs (sildenafil citrate, tadalafil, vardenafil hydrochloride trihydrate) and five previously identified synthetic analogues (methisosildenafil, homosildenafil, piperidenafil, thiosildenafil, thiomethisosildenafil) were measured to determine their reduced ion mobilities (K0). All eight compounds exhibited reduced mobilities between 0.8257 and 1.2876 cm2/(V s). Twenty-six herbal products were then screened for the presence of these compounds, and 15 of the 26 products tested positive for the presence of ED drug or drug analogue adulterants based on their reduced ion mobilities. IMS results were compared against the results obtained from an independent LC/MS reference method for the identical samples. Herbal dietary supplements containing adulterants were classified with 100% accuracy and most of the adulterants were correctly identified by a comparison of the K0 of the adulterant to the K0 of the authenticated reference material. The results demonstrate that IMS is a viable method for screening herbal dietary supplements for the presence of ED drug or drug analogue adulterants. JF - Journal of Pharmaceutical and Biomedical Analysis AU - Gryniewicz, Connie M AU - Reepmeyer, John C AU - Kauffman, John F AU - Buhse, Lucinda F AD - FDA, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, MO 63101, United States, Connie.Gryniewicz@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 601 EP - 606 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 49 IS - 3 SN - 0731-7085, 0731-7085 KW - Toxicology Abstracts KW - Ion mobility spectrometry KW - Erectile dysfunction drugs KW - Herbal dietary supplements KW - Adulterants KW - Mobility KW - Dietary supplements KW - Sildenafil KW - Drugs KW - Spectrometry KW - Citric acid KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20539460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.atitle=Detection+of+undeclared+erectile+dysfunction+drugs+and+analogues+in+dietary+supplements+by+ion+mobility+spectrometry&rft.au=Gryniewicz%2C+Connie+M%3BReepmeyer%2C+John+C%3BKauffman%2C+John+F%3BBuhse%2C+Lucinda+F&rft.aulast=Gryniewicz&rft.aufirst=Connie&rft.date=2009-04-01&rft.volume=49&rft.issue=3&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.issn=07317085&rft_id=info:doi/10.1016%2Fj.jpba.2008.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mobility; Dietary supplements; Sildenafil; Drugs; Citric acid; Spectrometry DO - http://dx.doi.org/10.1016/j.jpba.2008.12.002 ER - TY - JOUR T1 - Innate Immune Signals Modulate Antiviral and Polyreactive Antibody Responses during Severe Respiratory Syncytial Virus Infection AN - 20536150; 9225205 AB - Antiviral antibody production during respiratory syncytial virus (RSV) infection in infants is poorly understood. To characterize local B lymphocyte responses, lung tissue and secretions from infants with RSV bronchiolitis were analyzed for innate B cell-stimulating factors and antiviral antibodies. In lung tissues of infants with fatal RSV bronchiolitis, CD20 super(+) lymphocytes and IgM-positive, IgG-positive, and IgA-positive plasma cells were prominent but CD4 super(+) T lymphocytes were not. Type I interferon-induced proteins and B cell tropic factors, including B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL), were colocalized in infected epithelium. In nasopharyngeal secretions from infants who survived RSV infection, class-switched antiviral and antinucleosomal antibodies were detected at presentation and correlated with BAFF and APRIL levels. Expression of APRIL and antiviral antibodies of IgA and IgM but not IgG isotype predicted better oxygen saturation. We conclude that B lymphocyte- stimulating factors derived from infected epithelium are primary determinants of the mucosal antibody response in infant RSV bronchiolitis. JF - Journal of Infectious Diseases AU - Reed, Jennifer L AU - Welliver, Timothy P AU - Sims, Gary P AU - McKinney, LuAnn AU - Velozo, Luis AU - Avendano, Luis AU - Hintz, Karen AU - Luma, Jayson AU - Coyle, Anthony J AU - Welliver, Robert C AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, and Respiratory, Inflammation, and Autoimmunity Group, MedImmune, Gaithersburg, Maryland, jennifer.reed@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 1128 EP - 1138 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 8 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Lymphocytes B KW - Secretions KW - APRIL protein KW - Mucosa KW - Antibody response KW - Infection KW - Respiratory syncytial virus KW - Oxygen KW - CD4 antigen KW - Immunoglobulin A KW - Lung KW - Lymphocytes T KW - Immunoglobulin G KW - Epithelium KW - Plasma cells KW - Immunoglobulin M KW - Bronchopneumonia KW - BLyS protein KW - Infants KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20536150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Innate+Immune+Signals+Modulate+Antiviral+and+Polyreactive+Antibody+Responses+during+Severe+Respiratory+Syncytial+Virus+Infection&rft.au=Reed%2C+Jennifer+L%3BWelliver%2C+Timothy+P%3BSims%2C+Gary+P%3BMcKinney%2C+LuAnn%3BVelozo%2C+Luis%3BAvendano%2C+Luis%3BHintz%2C+Karen%3BLuma%2C+Jayson%3BCoyle%2C+Anthony+J%3BWelliver%2C+Robert+C&rft.aulast=Reed&rft.aufirst=Jennifer&rft.date=2009-04-01&rft.volume=199&rft.issue=8&rft.spage=1128&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F597386 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Lymphocytes B; Mucosa; APRIL protein; Secretions; Antibody response; Infection; Oxygen; Immunoglobulin A; CD4 antigen; Lung; Immunoglobulin G; Lymphocytes T; Epithelium; Plasma cells; Bronchopneumonia; Immunoglobulin M; Infants; BLyS protein; Respiratory syncytial virus DO - http://dx.doi.org/10.1086/597386 ER - TY - JOUR T1 - Multivariate analysis of variance test for gene set analysis AN - 20505359; 9195709 AB - Motivation: Gene class testing (GCT) or gene set analysis (GSA) is a statistical approach to determine whether some functionally predefined sets of genes express differently under different experimental conditions. Shortcomings of the Fisher's exact test for the overrepresentation analysis are illustrated by an example. Most alternative GSA methods are developed for data collected from two experimental conditions, and most is based on a univariate gene-by-gene test statistic or assume independence among genes in the gene set. A multivariate analysis of variance (MANOVA) approach is proposed for studies with two or more experimental conditions.Results: When the number of genes in the gene set is greater than the number of samples, the sample covariance matrix is singular and ill-condition. The use of standard multivariate methods can result in biases in the analysis. The proposed MANOVA test uses a shrinkage covariance matrix estimator for the sample covariance matrix. The MANOVA test and six other GSA published methods, principal component analysis, SAM-GS, analysis of covariance, Global, GSEA and MaxMean, are evaluated using simulation. The MANOVA test appears to perform the best in terms of control of type I error and power under the models considered in the simulation. Several publicly available microarray datasets under two and three experimental conditions are analyzed for illustrations of GSA. Most methods, except for GSEA and MaxMean, generally are comparable in terms of power of identification of significant gene sets.Availability: A free R-code to perform MANOVA test is available at http://mail.cmu.edu.tw/~catsai/research.htm . Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Tsai, Chen-An AU - Chen, James J AD - Graduate Institute of Biostatistics and Biostatistics Center, China Medical University, Taichung, Taiwan and 2 Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA, catsai@mail.cmu.edu.tw Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 897 EP - 903 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 25 IS - 7 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Statistics KW - Multivariate analysis KW - Principal components analysis KW - Atrophy KW - Bioinformatics KW - Models KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20505359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Multivariate+analysis+of+variance+test+for+gene+set+analysis&rft.au=Tsai%2C+Chen-An%3BChen%2C+James+J&rft.aulast=Tsai&rft.aufirst=Chen-An&rft.date=2009-04-01&rft.volume=25&rft.issue=7&rft.spage=897&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp098 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Statistics; Data processing; Multivariate analysis; Principal components analysis; Atrophy; Bioinformatics; Models DO - http://dx.doi.org/10.1093/bioinformatics/btp098 ER - TY - JOUR T1 - Human Papillomavirus Genotype Distributions: Implications for Vaccination and Cancer Screening in the United States AN - 20503133; 9195836 AB - Background Limited data are available describing human papillomavirus (HPV) genotype distributions in cervical cancer in the United States. Such studies are needed to predict how HPV vaccination and HPV-based screening will influence cervical cancer prevention.Methods We used the New Mexico Surveillance, Epidemiology, and End Results Registry to ascertain cases of in situ (n = 1213) and invasive (n = 808) cervical cancer diagnosed during 1985-1999 and 1980-1999, respectively, in the state of New Mexico. HPV genotyping was performed using two polymerase chain reaction-based methods on paraffin-embedded tissues from in situ and invasive cancers and on cervical Papanicolaou test specimen from control subjects (ie, women aged 18-40 years attending clinics for routine cervical screening [n = 4007]). Relative risks for cervical cancer were estimated, and factors associated with age at cancer diagnosis and the prevalence of HPV genotypes in cancers were examined.Results The most common HPV genotypes detected in invasive cancers were HPV type 16 (HPV16, 53.2%), HPV18 (13.1%), and HPV45 (6.1%) and those in in situ cancers were HPV16 (56.3%), HPV31 (12.6%), and HPV33 (8.0%). Invasive cancer case subjects who were positive for HPV16 or 18 were diagnosed at younger ages than those who were positive for other carcinogenic HPV genotypes (mean age at diagnosis: 48.1 [95% confidence interval {CI} = 46.6 to 49.6 years], 45.9 [95% CI = 42.9 to 49.0 years], and 52.3 years [95% CI = 50.0 to 54.6 years], respectively). The proportion of HPV16-positive in situ and invasive cancers, but not of HPV18-positive cancers, declined with more recent calendar year of diagnosis, whereas the proportion positive for carcinogenic HPV genotypes other than HPV18 increased.Conclusions HPV16 and 18 caused the majority of invasive cervical cancer in this population sample of US women, but the proportion attributable to HPV16 declined over the last 20 years. The age at diagnosis of HPV16- and HPV18-related cancers was 5 years earlier than that of cancers caused by carcinogenic HPV genotypes other than HPV16 and 18, suggesting that the age at initiation of cervical screening could be delayed in HPV-vaccinated populations. JF - Journal of the National Cancer Institute AU - Wheeler, Cosette M AU - Hunt, William C AU - Joste, Nancy E AU - Key, Charles R AU - Quint, Wim GV AU - Castle, Philip E AD - Affiliations of authors: Department of Molecular Genetics and Microbiology (CMW, WCH), Department of Obstetrics and Gynecology (CMW), Department of Pathology (NEJ, CRK), New Mexico Tumor Registry (CRK), School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM; DDL Diagnostic Laboratory, Voorburg, the Netherlands (WGVQ); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (PEC), cwheeler@salud.unm.edu Y1 - 2009/04/01/ PY - 2009 DA - 2009 Apr 01 SP - 475 EP - 487 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 101 IS - 7 SN - 0027-8874, 0027-8874 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Risk assessment KW - Cancer vaccines KW - USA, New Mexico KW - Invasiveness KW - Age KW - Data processing KW - Genotyping KW - Cervical cancer KW - Human papillomavirus 18 KW - Genotypes KW - Vaccination KW - Cancer KW - Epidemiology KW - Carcinogenicity KW - Human papillomavirus 16 KW - Cervix KW - Human papillomavirus KW - R2 23060:Medical and environmental health KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20503133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Human+Papillomavirus+Genotype+Distributions%3A+Implications+for+Vaccination+and+Cancer+Screening+in+the+United+States&rft.au=Wheeler%2C+Cosette+M%3BHunt%2C+William+C%3BJoste%2C+Nancy+E%3BKey%2C+Charles+R%3BQuint%2C+Wim+GV%3BCastle%2C+Philip+E&rft.aulast=Wheeler&rft.aufirst=Cosette&rft.date=2009-04-01&rft.volume=101&rft.issue=7&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn510 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Cancer vaccines; Age; Invasiveness; Data processing; Epidemiology; Genotyping; Cervical cancer; Genotypes; Cervix; Vaccination; Carcinogenicity; Cancer; Human papillomavirus 16; Human papillomavirus 18; Human papillomavirus; USA, New Mexico DO - http://dx.doi.org/10.1093/jnci/djn510 ER - TY - JOUR T1 - Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors AN - 20487714; 9179796 AB - Over the past decade, lentiviral vectors have emerged as powerful tools for transgene delivery. The use of lentiviral vectors has become commonplace and applications in the fields of neuroscience, hematology, developmental biology, stem cell biology and transgenesis are rapidly emerging. Also, lentiviral vectors are at present being explored in the context of human clinical trials. Here we describe improved protocols to generate highly concentrated lentiviral vector pseudotypes involving different envelope glycoproteins. In this protocol, vector stocks are prepared by transient transfection using standard cell culture media or serum-free media. Such stocks are then concentrated by ultracentrifugation and/or ion exchange chromatography, or by precipitation using polyethylene glycol 6000, resulting in vector titers of up to 10 super(10) transducing units per milliliter and above. We also provide reliable real-time PCR protocols to titrate lentiviral vectors based on proviral DNA copies present in genomic DNA extracted from transduced cells or on vector RNA. These production/concentration methods result in high-titer vector preparations that show reduced toxicity compared with lentiviral vectors produced using standard protocols involving ultracentrifugation-based methods. The vector production and titration protocol described here can be completed within 8 d. JF - Nature Protocols AU - Kutner, Robert H AU - Zhang, Xian-Yang AU - Reiser, Jakob Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 495 EP - 505 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 4 IS - 4 SN - 1754-2189, 1754-2189 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Genetic modification KW - Isolation KW - purification and separation KW - Microbiology and virology KW - Nucleic acid based molecular biology KW - Chromatography KW - Transgenes KW - Cell culture KW - Toxicity KW - Clinical trials KW - Ultracentrifugation KW - Nervous system KW - Stem cells KW - Envelopes KW - RNA KW - Human immunodeficiency virus KW - Transfection KW - Titration KW - Polymerase chain reaction KW - genomics KW - Glycoproteins KW - Polyethylene glycol KW - Ion exchange KW - Media (culture) KW - V 22360:AIDS and HIV KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20487714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Production%2C+concentration+and+titration+of+pseudotyped+HIV-1-based+lentiviral+vectors&rft.au=Kutner%2C+Robert+H%3BZhang%2C+Xian-Yang%3BReiser%2C+Jakob&rft.aulast=Kutner&rft.aufirst=Robert&rft.date=2009-04-01&rft.volume=4&rft.issue=4&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2009.22 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Chromatography; Transgenes; Cell culture; Toxicity; Ultracentrifugation; Clinical trials; Stem cells; Nervous system; Envelopes; RNA; Transfection; Titration; Polymerase chain reaction; Glycoproteins; genomics; Ion exchange; Polyethylene glycol; Media (culture); Human immunodeficiency virus DO - http://dx.doi.org/10.1038/nprot.2009.22 ER - TY - JOUR T1 - Qualified Health Claims for Calcium and Colorectal, Breast, and Prostate Cancers: The U.S. Food and Drug Administration's Evidence-Based Review AN - 20477957; 9178870 AB - In 2003, the United States Food and Drug Administration (FDA) received a health claim petition for calcium supplements and reduced risk of colorectal, breast, and prostate cancers. Health claims characterize the relationship between a substance (food or food component) and disease (e.g., cancer or cardiovascular disease) or health-related condition (e.g., hypertension) and require premar-ket approval for the labeling of conventional foods and dietary supplements by the FDA. This review describes how the FDA used the evidence-based review system to evaluate the scientific evidence for these proposed health claims. FDA found no credible evidence to support health claims for calcium and a reduced risk of breast and prostate cancers. The agency did find limited evidence for the relationship between calcium intake and colorectal cancer risk. JF - Nutrition and Cancer AU - Kavanaugh, C J AU - Trumbo, PR AU - Ellwood, K C AD - U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, HFS-830, 5100 Paint Branch Parkway, College Park, MD 20740, USA, claudine.kavanaugh@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 157 EP - 164 VL - 61 IS - 2 SN - 0163-5581, 0163-5581 KW - Calcium & Calcified Tissue Abstracts; Risk Abstracts KW - Calcium KW - dietary supplements KW - Colorectal cancer KW - Cancer KW - risk reduction KW - USA KW - Prostate cancer KW - colorectal carcinoma KW - Reviews KW - Dietary supplements KW - hypertension KW - FDA KW - Cardiovascular diseases KW - prostate cancer KW - Drugs KW - Hypertension KW - R2 23060:Medical and environmental health KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20477957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+and+Cancer&rft.atitle=Qualified+Health+Claims+for+Calcium+and+Colorectal%2C+Breast%2C+and+Prostate+Cancers%3A+The+U.S.+Food+and+Drug+Administration%27s+Evidence-Based+Review&rft.au=Kavanaugh%2C+C+J%3BTrumbo%2C+PR%3BEllwood%2C+K+C&rft.aulast=Kavanaugh&rft.aufirst=C&rft.date=2009-04-01&rft.volume=61&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Nutrition+and+Cancer&rft.issn=01635581&rft_id=info:doi/10.1080%2F01635580802395741 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Prostate cancer; Calcium; Dietary supplements; Reviews; Colorectal cancer; Cardiovascular diseases; Hypertension; risk reduction; dietary supplements; colorectal carcinoma; hypertension; FDA; prostate cancer; Drugs; Cancer; USA DO - http://dx.doi.org/10.1080/01635580802395741 ER - TY - JOUR T1 - Overlapping but distinct effects of genistein and ethinyl estradiol (EE sub(2)) in female Sprague-Dawley rats in multigenerational reproductive and chronic toxicity studies AN - 20474341; 9166125 AB - Genistein and ethinyl estradiol (EE sub(2)) were examined in multigenerational reproductive and chronic toxicity studies that had different treatment intervals among generations. Sprague-Dawley rats received genistein (0, 5, 100, or 500ppm) or EE sub(2) (0, 2, 10, or 50ppb) in a low phytoestrogen diet. Nonneoplastic effects in females are summarized here. Genistein at 500ppm and EE sub(2) at 50ppb produced similar effects in continuously exposed rats, including decreased body weights, accelerated vaginal opening, and altered estrous cycles in young animals. At the high dose, anogenital distance was subtly affected by both compounds, and a reduction in litter size was evident in genistein-treated animals. Genistein at 500ppm induced an early onset of aberrant cycles relative to controls in the chronic studies. EE sub(2) significantly increased the incidence of uterine lesions (atypical focal hyperplasia and squamous metaplasia). These compound-specific effects appeared to be enhanced in the offspring of prior exposed generations. JF - Reproductive Toxicology AU - Delclos, K B AU - Weis, C C AU - Bucci, T J AU - Olson, G AU - Mellick, P AU - Sadovova, N AU - Latendresse, J R AU - Thorn, B AU - Newbold, R R AD - Jefferson, AR 72079, United States, barry.delclos@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 117 EP - 132 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 27 IS - 2 SN - 0890-6238, 0890-6238 KW - Genetics Abstracts; Toxicology Abstracts KW - Uterus KW - Litter KW - Anogenital KW - Hyperplasia KW - Nutrient deficiency KW - Estrus KW - Ethinyl estradiol KW - Body weight KW - Metaplasia KW - Chronic toxicity KW - Vagina KW - Phytoestrogens KW - Progeny KW - Genistein KW - X 24310:Pharmaceuticals KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20474341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Overlapping+but+distinct+effects+of+genistein+and+ethinyl+estradiol+%28EE+sub%282%29%29+in+female+Sprague-Dawley+rats+in+multigenerational+reproductive+and+chronic+toxicity+studies&rft.au=Delclos%2C+K+B%3BWeis%2C+C+C%3BBucci%2C+T+J%3BOlson%2C+G%3BMellick%2C+P%3BSadovova%2C+N%3BLatendresse%2C+J+R%3BThorn%2C+B%3BNewbold%2C+R+R&rft.aulast=Delclos&rft.aufirst=K&rft.date=2009-04-01&rft.volume=27&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2008.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Litter; Uterus; Anogenital; Nutrient deficiency; Hyperplasia; Ethinyl estradiol; Estrus; Body weight; Chronic toxicity; Metaplasia; Vagina; Phytoestrogens; Progeny; Genistein DO - http://dx.doi.org/10.1016/j.reprotox.2008.12.005 ER - TY - JOUR T1 - The survivability of Bacillus anthracis (Sterne strain) in processed liquid eggs AN - 20289689; 8898552 AB - In this study, we investigated the survival and inactivation kinetics of a surrogate strain of Bacillus anthracis (Sterne strain) in whole egg (WE), egg white (EW), sugared egg yolk (YSU), and salted egg yolk (YSA) at low (-20, 0, and 5 super(o)C), moderate (15, 20, 25, 30, 35, and 40 super(o)C), and high storage temperatures (45, 50, 55, and 60 super(o)C). Outgrowth of the spores was measured as lag phase duration (LPD). Replication of vegetative cells was measured in terms of growth rate (GR) and maximum population density (MPD). Spore inactivation was recorded as inactivation rate and percent reduction in viable count. In general, spore viability decreased at low and high temperatures and increased at moderate temperatures. At 0 and 5 super(o)C, a 60-100% reduction in spore viability was seen within 2-3weeks in WE and YSU, 0-30% in YSA, and 50-100% in EW. At -20 super(o)C, however, no drop in spore titer was observed in YSU and EW but a 20% drop in titer was seen in YSA and 50% in WE within 2-3weeks. At high temperatures, WE, EW, and YSA produced a 20-50% drop in the spore titer within 1-4h whereas YSU showed 100% inactivation within 0.75h. At moderate storage temperatures, as the temperature increased from 15 to 40 super(o)C, LPD decreased from 13.5 to 0.75h and MPD reached 0.27-2.2x10 super(9) CFU/ml in YSU and WE, respectively. Markedly lower growth was observed in YSA (LPD=24-270h, MPD=9x10 super(5) CFU/ml) and spores were inactivated completely within 1-6h in EW. The survivability and inactivation data of B. anthracis in liquid egg products reported in this investigation will be helpful in developing risk assessment models on food biosecurity. JF - Food Microbiology AU - Khan, SA AU - Sung, K AU - Nawaz AU - Cerniglia, CE AU - Tamplin, M L AU - Phillips, R W AU - Kelley, L C AD - National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA, saeed.khan@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 123 EP - 127 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 26 IS - 2 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Growth rate KW - Risk assessment KW - Temperature effects KW - Lag phase KW - Data processing KW - Replication KW - Food KW - Population density KW - Survival KW - Bacillus anthracis KW - Vegetative cells KW - Eggs KW - Yolk KW - Albumen KW - Kinetics KW - Colony-forming cells KW - Spores KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20289689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=The+survivability+of+Bacillus+anthracis+%28Sterne+strain%29+in+processed+liquid+eggs&rft.au=Khan%2C+SA%3BSung%2C+K%3BNawaz%3BCerniglia%2C+CE%3BTamplin%2C+M+L%3BPhillips%2C+R+W%3BKelley%2C+L+C&rft.aulast=Khan&rft.aufirst=SA&rft.date=2009-04-01&rft.volume=26&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2008.10.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; Risk assessment; Growth rate; Lag phase; Data processing; Replication; Food; Population density; Survival; Vegetative cells; Eggs; Yolk; Albumen; Colony-forming cells; Kinetics; Spores; Bacillus anthracis DO - http://dx.doi.org/10.1016/j.fm.2008.10.009 ER - TY - JOUR T1 - Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F sub(1) mice AN - 20093793; 10254988 AB - Usnic acid is a lichen metabolite used as a weight-loss dietary supplement due to its uncoupling action on mitochondria. However, its use has been associated with severe liver disorders in some individuals. Animal studies conducted thus far evaluated the effects of usnic acid on mitochondria primarily by measuring the rate of oxygen consumption and/or ATP generation. To obtain further insight into usnic acid-mediated effects on mitochondria, we examined the expression levels of 542 genes associated with mitochondrial structure and functions in liver of B6C3F sub(1) female mice using a mitochondria-specific microarray. Beginning at 8 weeks of age, mice received usnic acid at 0, 60, 180, and 600 ppm in ground, irradiated 5LG6 diet for 14 days. Microarray analysis showed a significant effect of usnic acid on the expression of several genes only at the highest dose of 600 ppm. A prominent finding of the study was a significant induction of genes associated with complexes I through IV of the electron transport chain. Moreover, several genes involved in fatty acid oxidation, the Krebs cycle, apoptosis, and membrane transporters were over-expressed. Usnic acid is a lipophilic weak acid that can diffuse through mitochondrial membranes and cause a proton leak (uncoupling). The up-regulation of complexes I-IV may be a compensatory mechanism to maintain the proton gradient across the mitochondrial inner membrane. In addition, induction of fatty acid oxidation and the Krebs cycle may be an adaptive response to uncoupling of mitochondria. JF - Mitochondrion AU - Joseph, Ajay AU - Lee, Taewon AU - Moland, Carrie L AU - Branham, William S AU - Fuscoe, James C AU - Leakey, Julian EA AU - Allaben, William T AU - Lewis, Sherry M AU - Ali, Akhtar A AU - Desai, Varsha G AD - University of Abertay Dundee, DD1 1HG Dundee, UK, varsha.desai@fda.hhs.gov Y1 - 2009/04// PY - 2009 DA - Apr 2009 SP - 149 EP - 158 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 9 IS - 2 SN - 1567-7249, 1567-7249 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Usnic acid KW - Liver KW - Female B6C3F sub(1) mice KW - Gene expression KW - Mitochondrial functions KW - Oxygen consumption KW - Age KW - Apoptosis KW - Liver diseases KW - Protons KW - Mitochondria KW - ATP KW - Metabolites KW - Oligonucleotides KW - Lipophilic KW - Lichens KW - Inner membranes KW - Dietary supplements KW - Oxidation KW - Fatty acids KW - Tricarboxylic acid cycle KW - Electron transport chain KW - N 14810:Methods KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20093793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mitochondrion&rft.atitle=Effect+of+%28%2B%29-usnic+acid+on+mitochondrial+functions+as+measured+by+mitochondria-specific+oligonucleotide+microarray+in+liver+of+B6C3F+sub%281%29+mice&rft.au=Joseph%2C+Ajay%3BLee%2C+Taewon%3BMoland%2C+Carrie+L%3BBranham%2C+William+S%3BFuscoe%2C+James+C%3BLeakey%2C+Julian+EA%3BAllaben%2C+William+T%3BLewis%2C+Sherry+M%3BAli%2C+Akhtar+A%3BDesai%2C+Varsha+G&rft.aulast=Joseph&rft.aufirst=Ajay&rft.date=2009-04-01&rft.volume=9&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Mitochondrion&rft.issn=15677249&rft_id=info:doi/10.1016%2Fj.mito.2009.02.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Oxygen consumption; Age; Liver diseases; Apoptosis; Protons; ATP; Mitochondria; Metabolites; Oligonucleotides; Lipophilic; Lichens; Dietary supplements; Inner membranes; Oxidation; Fatty acids; Liver; Usnic acid; Tricarboxylic acid cycle; Electron transport chain DO - http://dx.doi.org/10.1016/j.mito.2009.02.002 ER - TY - JOUR T1 - Increased cell proliferation in spleen and lymph nodes peripheral to contact allergen application site. AN - 66954231; 19150643 AB - The local lymph node assay (LLNA) is widely used to identify chemicals that are contact sensitizers. The assay involves dosing mice with the chemical on both ears and pooling the superficial parotid lymph nodes for assessment of lymphocyte proliferation as a marker of sensitization. The present study explored potential reduction in animal usage by dosing one ear with the allergen and the other with vehicle-only. The respective draining lymph nodes were processed separately for tritiated thymidine ((3)H-TdR) incorporation. Cell proliferation in proper axillary and renal nodes, as well as in the spleen was also assessed. Cross-contamination of the chemicals from the dosed ears to other parts of the body via preening was prevented by dosing restrained animals and washing off the residual chemical with saline after 4h. Dosing the left ear with 0.02% oxazolone (OX) on unrestrained animals resulted in marked cell proliferation in its draining lymph node (stimulation index, SI=12.8) and in the lymph node draining the contra-lateral vehicle-dosed ear (SI=6), as well as the proper axillary lymph nodes (SI=3.3). Increased (3)H-TdR incorporation was not observed in the renal lymph nodes (SI=1.1). Similar stimulation of cells was observed in the lymph node draining the ear contra-lateral to the 30% hexylcinnamaldehyde (HCA)-dosed ear. Increased proliferative activity was observed in contra-lateral draining lymph nodes of restrained mice demonstrating that these results cannot be attributed to cross-contamination of adjacent skin. A significant increase in proliferation of splenocytes was also observed. It is concluded that dermal application of a contact allergen, as exemplified by OX and HCA, may induce cell proliferation in the neighboring lymph nodes and spleen indicative of hapten and/or haptenated proteins diffusing through the skin to peripheral nodes and the blood to produce systemic sensitization. It is also possible that lymphatic capillaries may communicate between the left and right side of the mouse head. Thus the contra-lateral draining superficial parotid node cannot be used as a control for application of contact allergen to a single ear in a modified LLNA. JF - Toxicology AU - Chipinda, Itai AU - Anderson, Stacey E AU - Butterworth, Leon F AU - Beezhold, Donald AU - Siegel, Paul D AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, United States. IChipinda@cdc.gov Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 SP - 113 EP - 116 VL - 257 IS - 3 SN - 0300-483X, 0300-483X KW - Allergens KW - 0 KW - Oxazolone KW - 15646-46-5 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Animals KW - Oxazolone -- pharmacology KW - Mice KW - Terminology as Topic KW - Local Lymph Node Assay KW - Mice, Inbred BALB C KW - Thymidine -- pharmacology KW - Female KW - Cell Proliferation -- drug effects KW - Dermatitis, Contact -- pathology KW - Allergens -- toxicity KW - Lymph Nodes -- pathology KW - Spleen -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66954231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Increased+cell+proliferation+in+spleen+and+lymph+nodes+peripheral+to+contact+allergen+application+site.&rft.au=Chipinda%2C+Itai%3BAnderson%2C+Stacey+E%3BButterworth%2C+Leon+F%3BBeezhold%2C+Donald%3BSiegel%2C+Paul+D&rft.aulast=Chipinda&rft.aufirst=Itai&rft.date=2009-03-29&rft.volume=257&rft.issue=3&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2008.12.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-20 N1 - Date created - 2009-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2008.12.019 ER - TY - JOUR T1 - Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes. AN - 66947478; 19150385 AB - Single-walled carbon nanotubes (SWCNT) represent a novel material with unique electronic and mechanical properties. The extremely small size ( approximately 1 nm diameter) renders their chemical and physical properties unique. A variety of different techniques are available for the production of SWCNT; however, the most common is via the disproportionation of gaseous carbon molecules supported on catalytic iron particles (high-pressure CO conversion, HiPCO). The physical nature of SWCNT may lead to dermal penetration following deposition on exposed skin. This dermal deposition provides a route of exposure which is important to consider when evaluating SWCNT toxicity. The dermal effects of SWCNT are largely unknown. We hypothesize that SWCNT may be toxic to the skin. We further hypothesize that SWCNT toxicity may be dependent upon the metal (particularly iron) content of SWCNT via the metal's ability to interact with the skin, initiate oxidative stress, and induce redox-sensitive transcription factors thereby affecting/leading to inflammation. To test this hypothesis, the effects of SWCNT were assessed both in vitro and in vivo using EpiDerm FT engineered skin, murine epidermal cells (JB6 P+), and immune-competent hairless SKH-1 mice. Engineered skin exposed to SWCNT showed increased epidermal thickness and accumulation and activation of dermal fibroblasts which resulted in increased collagen as well as release of pro-inflammatory cytokines. Exposure of JB6 P+ cells to unpurified SWCNT (30% iron) resulted in the production of ESR detectable hydroxyl radicals and caused a significant dose-dependent activation of AP-1. No significant changes in AP-1 activation were detected when partially purified SWCNT (0.23% iron) were introduced to the cells. However, NFkappaB was activated in a dose-dependent fashion by exposure to both unpurified and partially purified SWCNT. Topical exposure of SKH-1 mice (5 days, with daily doses of 40 microg/mouse, 80 microg/mouse, or 160 microug/mouse) to unpurified SWCNT caused oxidative stress, depletion of glutathione, oxidation of protein thiols and carbonyls, elevated myeloperoxidase activity, an increase of dermal cell numbers, and skin thickening resulting from the accumulation of polymorphonuclear leukocytes (PMNs) and mast cells. Altogether, these data indicated that topical exposure to unpurified SWCNT, induced free radical generation, oxidative stress, and inflammation, thus causing dermal toxicity. JF - Toxicology AU - Murray, A R AU - Kisin, E AU - Leonard, S S AU - Young, S H AU - Kommineni, C AU - Kagan, V E AU - Castranova, V AU - Shvedova, A A AD - Health Effects Laboratory Division, Pathology and Physiology Research Branch, NIOSH, M/L 2015, 1095 Willowdale Road, Morgantown, WV 26505, United States. zsk1@cdc.gov Y1 - 2009/03/29/ PY - 2009 DA - 2009 Mar 29 SP - 161 EP - 171 VL - 257 IS - 3 SN - 0300-483X, 0300-483X KW - Cytokines KW - 0 KW - Free Radicals KW - NF-kappa B KW - Nanotubes, Carbon KW - Oxazines KW - Transcription Factor AP-1 KW - Xanthenes KW - resazurin KW - 1FN9YD6968 KW - Collagen KW - 9007-34-5 KW - Peroxidase KW - EC 1.11.1.7 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Tissue Engineering KW - Transcription Factor AP-1 -- biosynthesis KW - Collagen -- metabolism KW - Skin -- metabolism KW - Cytokines -- biosynthesis KW - Glutathione -- metabolism KW - Humans KW - Skin -- pathology KW - Peroxidase -- metabolism KW - Mice KW - Mice, Hairless KW - Transcription Factor AP-1 -- genetics KW - Free Radicals -- immunology KW - NF-kappa B -- genetics KW - NF-kappa B -- biosynthesis KW - Skin -- drug effects KW - Cell Survival -- drug effects KW - Electron Spin Resonance Spectroscopy KW - Cell Line KW - Inflammation -- chemically induced KW - Oxidative Stress -- drug effects KW - Skin Diseases -- pathology KW - Skin Diseases -- chemically induced KW - Nanotubes, Carbon -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66947478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Oxidative+stress+and+inflammatory+response+in+dermal+toxicity+of+single-walled+carbon+nanotubes.&rft.au=Murray%2C+A+R%3BKisin%2C+E%3BLeonard%2C+S+S%3BYoung%2C+S+H%3BKommineni%2C+C%3BKagan%2C+V+E%3BCastranova%2C+V%3BShvedova%2C+A+A&rft.aulast=Murray&rft.aufirst=A&rft.date=2009-03-29&rft.volume=257&rft.issue=3&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2008.12.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-20 N1 - Date created - 2009-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2008.12.023 ER - TY - CPAPER T1 - Approaching a Safety Analysis Plan to Address Adverse Events of Special Interest T2 - 21st Annual Euro Meeting of the Drug Information Association AN - 41835784; 5043609 JF - 21st Annual Euro Meeting of the Drug Information Association AU - Rochester, George Y1 - 2009/03/23/ PY - 2009 DA - 2009 Mar 23 KW - Side effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41835784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.atitle=Approaching+a+Safety+Analysis+Plan+to+Address+Adverse+Events+of+Special+Interest&rft.au=Rochester%2C+George&rft.aulast=Rochester&rft.aufirst=George&rft.date=2009-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= %2fproductfiles%2f16920%2f09101%2Epdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - US Regulatory Perspective - Draft FDA Guidance T2 - 21st Annual Euro Meeting of the Drug Information Association AN - 41816992; 5043603 JF - 21st Annual Euro Meeting of the Drug Information Association AU - O'Neill, Robert Y1 - 2009/03/23/ PY - 2009 DA - 2009 Mar 23 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41816992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.atitle=US+Regulatory+Perspective+-+Draft+FDA+Guidance&rft.au=O%27Neill%2C+Robert&rft.aulast=O%27Neill&rft.aufirst=Robert&rft.date=2009-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= %2fproductfiles%2f16920%2f09101%2Epdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of PET Imaging Probes for Use in General Toxicology - The New Biomarker T2 - 21st Annual Euro Meeting of the Drug Information Association AN - 41814986; 5043650 JF - 21st Annual Euro Meeting of the Drug Information Association AU - Slikker, William Y1 - 2009/03/23/ PY - 2009 DA - 2009 Mar 23 KW - Bioindicators KW - Toxicology KW - Probes KW - Biomarkers KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41814986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.atitle=Development+of+PET+Imaging+Probes+for+Use+in+General+Toxicology+-+The+New+Biomarker&rft.au=Slikker%2C+William&rft.aulast=Slikker&rft.aufirst=William&rft.date=2009-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= %2fproductfiles%2f16920%2f09101%2Epdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Agency Panel T2 - 21st Annual Euro Meeting of the Drug Information Association AN - 41803159; 5043612 JF - 21st Annual Euro Meeting of the Drug Information Association AU - O'Neill, Robert AU - Hemmings, Robert Y1 - 2009/03/23/ PY - 2009 DA - 2009 Mar 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41803159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.atitle=Regulatory+Agency+Panel&rft.au=O%27Neill%2C+Robert%3BHemmings%2C+Robert&rft.aulast=O%27Neill&rft.aufirst=Robert&rft.date=2009-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= %2fproductfiles%2f16920%2f09101%2Epdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Simplification - The Next Steps Forward T2 - 21st Annual Euro Meeting of the Drug Information Association AN - 41802869; 5043740 JF - 21st Annual Euro Meeting of the Drug Information Association AU - Lumpkin, Murray Y1 - 2009/03/23/ PY - 2009 DA - 2009 Mar 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41802869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.atitle=Regulatory+Simplification+-+The+Next+Steps+Forward&rft.au=Lumpkin%2C+Murray&rft.aulast=Lumpkin&rft.aufirst=Murray&rft.date=2009-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= %2fproductfiles%2f16920%2f09101%2Epdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Weibull Failure-Time Mixture Models for Evaluating Efficacy in the Presence of a Biomarker T2 - 21st Annual Euro Meeting of the Drug Information Association AN - 41802372; 5043614 JF - 21st Annual Euro Meeting of the Drug Information Association AU - Koti, Kallappa Y1 - 2009/03/23/ PY - 2009 DA - 2009 Mar 23 KW - Bioindicators KW - Biomarkers KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41802372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.atitle=Weibull+Failure-Time+Mixture+Models+for+Evaluating+Efficacy+in+the+Presence+of+a+Biomarker&rft.au=Koti%2C+Kallappa&rft.aulast=Koti&rft.aufirst=Kallappa&rft.date=2009-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= %2fproductfiles%2f16920%2f09101%2Epdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Established Biomarkers and How Much Time towards Medical Meaningfulness T2 - 21st Annual Euro Meeting of the Drug Information Association AN - 41772570; 5043673 JF - 21st Annual Euro Meeting of the Drug Information Association AU - Lesko, Lawrence Y1 - 2009/03/23/ PY - 2009 DA - 2009 Mar 23 KW - Bioindicators KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41772570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.atitle=Established+Biomarkers+and+How+Much+Time+towards+Medical+Meaningfulness&rft.au=Lesko%2C+Lawrence&rft.aulast=Lesko&rft.aufirst=Lawrence&rft.date=2009-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= %2fproductfiles%2f16920%2f09101%2Epdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Safe Use: Improving the Safety of Medicines T2 - 21st Annual Euro Meeting of the Drug Information Association AN - 41761123; 5043478 JF - 21st Annual Euro Meeting of the Drug Information Association AU - Smith, Nancy Y1 - 2009/03/23/ PY - 2009 DA - 2009 Mar 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41761123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.atitle=Safe+Use%3A+Improving+the+Safety+of+Medicines&rft.au=Smith%2C+Nancy&rft.aulast=Smith&rft.aufirst=Nancy&rft.date=2009-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Euro+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= %2fproductfiles%2f16920%2f09101%2Epdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - RPRT T1 - U.S. FOOD AND DRUG ADMINISTRATION HEADQUARTERS CONSOLIDATION, MONTGOMERY COUNTY, MARYLAND (DRAFT SUPPLEMENT TO THE FINAL ENVIRONMENTAL IMPACT STATEMENT OF April 1997). [Part 2 of 2] T2 - U.S. FOOD AND DRUG ADMINISTRATION HEADQUARTERS CONSOLIDATION, MONTGOMERY COUNTY, MARYLAND (DRAFT SUPPLEMENT TO THE FINAL ENVIRONMENTAL IMPACT STATEMENT OF April 1997). AN - 756824587; 13811-090086_0002 AB - PURPOSE: Revision of the Food and Drug Administration's (FDA) 2006 Master Plan for the consolidation of FDA's headquarters facilities to a state-of-the-art facility at a single location in Silver Spring, Montgomery County, Maryland is proposed. The General Services Administration (GSA) is currently developing new facilities at the Federal Research Center (FRC) at White Oak for FDA's Office of the Commissioner, Office of Regulatory Affairs, the Center for Drug Evaluation and Research, the Center for Devices and Radiological Health, the Center for Biologics Evaluation and Research, and the Center for Veterinary Medicine. Since the preparation of the 1997 final EIS and the 2005 final supplemental EIS, congressional mandates have resulted in expansions to FDA's programs and GSA is updating the FDA Headquarters Master Plan to accommodate additional growth on the 130-acre campus. The plan is based on grouping buildings for the six FDA research and administrative functions around a central campus that serves to unite the functions and link the campus to the woodlands to the east. Three alternatives, including a No Action Alternative, are considered in this draft supplemental EIS. The proposed action would construct facilities to accommodate the increase of FDA employees from 7,719 to 8,889, change the placement of a 10,000-square foot child care center, construct a 10,000-square foot fitness center, relocate the 25,000-square foot broadcast studio, expand the central utility plant by 50,000 square feet, and construct a 300,000 gallon elevated water storage tank for potable water. The proposed action would add an additional 1.3 million gross square feet of space to support FDA's mission for a total of almost 6 million square feet. Two parking spaces would be provided for every three employees while visitor parking would be increased from 500 to 1,000 spaces for a total of 6,926 parking spaces on the FDA campus. The Dispersed Density Alternative (Alternative 2) would follow existing building heights to maintain uniformity across the campus and would add a northwest parking garage. Under the Southeast Quadrant Density Alternative (Alternative 3), building heights would be greater than that of existing buildings locating most of the density in the southeastern part of the campus. POSITIVE IMPACTS: The proposed action would accommodate the projected increase in FDA personnel within the 130 acres appropriated by Congress for the FDA headquarters. Expanded office and laboratory space and the associated infrastructure improvements would allow the additional employees to conduct the complex and comprehensive reviews of new drugs and medical devices which are part of FDA's mandated programs. The use of the central utility plant would have moderate, long-term beneficial impacts to overall energy supplies. Under the action alternatives, employment would increase by 1,170 employees by 2012. NEGATIVE IMPACTS: The action proposed in this draft supplemental EIS would have moderate, long-term, adverse impacts from the clearing, grading, and construction activities that would affect soils. An erosion and sediment plan would be implemented to control and reduce sediments from entering storm drains and adjacent streams. The total impervious surface area under alternatives 2 and 3 would be increased by 5.6 and 2.9 acres, respectively, over the No Action alternative, with consequent minor, long-term, adverse effects to groundwater quality and hydrology. The proposed locations for the broadcast studio and water storage tank would have direct impacts to wetlands and associated buffers. Under the action alternatives, the FDA headquarters consolidation would continue to have moderate, long-term impacts on traffic levels with the additional employees generating approximately 777 vehicle trips in the morning and evening peak hours and improvements to several intersections would be needed. Buildings proposed under the action alternatives would adversely impact views from adjacent streets and apartment communities. The proposed water tower would have a total elevation of 471 to 476 feet and would stand more than 20 feet taller than any surrounding structure. LEGAL MANDATES: National Capital Planning Act of 1952 (40 U.S.C. 71d(a)) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstracts of the draft and final EISs, see 96-0183D, Volume 20, Number 2 and 97-0143F, Volume 21, Number 2, respectively. For the abstracts of previous draft and final supplemental EISs, see 05-0253D, Volume 28, Number 2 and 05-0666F, Volume 29, Number 4, respectively. JF - EPA number: 090086, Draft Supplemental EIS--224 page, Appendices--389 pages, March 20, 2009 PY - 2009 VL - 2 KW - Urban and Social Programs KW - Air Quality Assessments KW - Buildings KW - Employment KW - Forests KW - Health Hazard KW - Land Use KW - Noise Assessments KW - Parking KW - Public Health KW - Research Facilities KW - Site Planning KW - Traffic Analyses KW - Water Storage KW - Maryland KW - National Historic Preservation Act of 1966, Historic Sites KW - National Capital Planning Act of 1952, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756824587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28DRAFT+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+April+1997%29.&rft.title=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28DRAFT+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+April+1997%29.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Washington, District of Columbia; GSA N1 - Date revised - 2009-07-16 N1 - SuppNotes - Draft. Preparation date: March 20, 2009 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - U.S. FOOD AND DRUG ADMINISTRATION HEADQUARTERS CONSOLIDATION, MONTGOMERY COUNTY, MARYLAND (DRAFT SUPPLEMENT TO THE FINAL ENVIRONMENTAL IMPACT STATEMENT OF April 1997). [Part 1 of 2] T2 - U.S. FOOD AND DRUG ADMINISTRATION HEADQUARTERS CONSOLIDATION, MONTGOMERY COUNTY, MARYLAND (DRAFT SUPPLEMENT TO THE FINAL ENVIRONMENTAL IMPACT STATEMENT OF April 1997). AN - 756824586; 13811-090086_0001 AB - PURPOSE: Revision of the Food and Drug Administration's (FDA) 2006 Master Plan for the consolidation of FDA's headquarters facilities to a state-of-the-art facility at a single location in Silver Spring, Montgomery County, Maryland is proposed. The General Services Administration (GSA) is currently developing new facilities at the Federal Research Center (FRC) at White Oak for FDA's Office of the Commissioner, Office of Regulatory Affairs, the Center for Drug Evaluation and Research, the Center for Devices and Radiological Health, the Center for Biologics Evaluation and Research, and the Center for Veterinary Medicine. Since the preparation of the 1997 final EIS and the 2005 final supplemental EIS, congressional mandates have resulted in expansions to FDA's programs and GSA is updating the FDA Headquarters Master Plan to accommodate additional growth on the 130-acre campus. The plan is based on grouping buildings for the six FDA research and administrative functions around a central campus that serves to unite the functions and link the campus to the woodlands to the east. Three alternatives, including a No Action Alternative, are considered in this draft supplemental EIS. The proposed action would construct facilities to accommodate the increase of FDA employees from 7,719 to 8,889, change the placement of a 10,000-square foot child care center, construct a 10,000-square foot fitness center, relocate the 25,000-square foot broadcast studio, expand the central utility plant by 50,000 square feet, and construct a 300,000 gallon elevated water storage tank for potable water. The proposed action would add an additional 1.3 million gross square feet of space to support FDA's mission for a total of almost 6 million square feet. Two parking spaces would be provided for every three employees while visitor parking would be increased from 500 to 1,000 spaces for a total of 6,926 parking spaces on the FDA campus. The Dispersed Density Alternative (Alternative 2) would follow existing building heights to maintain uniformity across the campus and would add a northwest parking garage. Under the Southeast Quadrant Density Alternative (Alternative 3), building heights would be greater than that of existing buildings locating most of the density in the southeastern part of the campus. POSITIVE IMPACTS: The proposed action would accommodate the projected increase in FDA personnel within the 130 acres appropriated by Congress for the FDA headquarters. Expanded office and laboratory space and the associated infrastructure improvements would allow the additional employees to conduct the complex and comprehensive reviews of new drugs and medical devices which are part of FDA's mandated programs. The use of the central utility plant would have moderate, long-term beneficial impacts to overall energy supplies. Under the action alternatives, employment would increase by 1,170 employees by 2012. NEGATIVE IMPACTS: The action proposed in this draft supplemental EIS would have moderate, long-term, adverse impacts from the clearing, grading, and construction activities that would affect soils. An erosion and sediment plan would be implemented to control and reduce sediments from entering storm drains and adjacent streams. The total impervious surface area under alternatives 2 and 3 would be increased by 5.6 and 2.9 acres, respectively, over the No Action alternative, with consequent minor, long-term, adverse effects to groundwater quality and hydrology. The proposed locations for the broadcast studio and water storage tank would have direct impacts to wetlands and associated buffers. Under the action alternatives, the FDA headquarters consolidation would continue to have moderate, long-term impacts on traffic levels with the additional employees generating approximately 777 vehicle trips in the morning and evening peak hours and improvements to several intersections would be needed. Buildings proposed under the action alternatives would adversely impact views from adjacent streets and apartment communities. The proposed water tower would have a total elevation of 471 to 476 feet and would stand more than 20 feet taller than any surrounding structure. LEGAL MANDATES: National Capital Planning Act of 1952 (40 U.S.C. 71d(a)) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstracts of the draft and final EISs, see 96-0183D, Volume 20, Number 2 and 97-0143F, Volume 21, Number 2, respectively. For the abstracts of previous draft and final supplemental EISs, see 05-0253D, Volume 28, Number 2 and 05-0666F, Volume 29, Number 4, respectively. JF - EPA number: 090086, Draft Supplemental EIS--224 page, Appendices--389 pages, March 20, 2009 PY - 2009 VL - 1 KW - Urban and Social Programs KW - Air Quality Assessments KW - Buildings KW - Employment KW - Forests KW - Health Hazard KW - Land Use KW - Noise Assessments KW - Parking KW - Public Health KW - Research Facilities KW - Site Planning KW - Traffic Analyses KW - Water Storage KW - Maryland KW - National Historic Preservation Act of 1966, Historic Sites KW - National Capital Planning Act of 1952, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756824586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28DRAFT+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+April+1997%29.&rft.title=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28DRAFT+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+April+1997%29.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Washington, District of Columbia; GSA N1 - Date revised - 2009-07-16 N1 - SuppNotes - Draft. Preparation date: March 20, 2009 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - U.S. FOOD AND DRUG ADMINISTRATION HEADQUARTERS CONSOLIDATION, MONTGOMERY COUNTY, MARYLAND (DRAFT SUPPLEMENT TO THE FINAL ENVIRONMENTAL IMPACT STATEMENT OF April 1997). AN - 36344705; 13811 AB - PURPOSE: Revision of the Food and Drug Administration's (FDA) 2006 Master Plan for the consolidation of FDA's headquarters facilities to a state-of-the-art facility at a single location in Silver Spring, Montgomery County, Maryland is proposed. The General Services Administration (GSA) is currently developing new facilities at the Federal Research Center (FRC) at White Oak for FDA's Office of the Commissioner, Office of Regulatory Affairs, the Center for Drug Evaluation and Research, the Center for Devices and Radiological Health, the Center for Biologics Evaluation and Research, and the Center for Veterinary Medicine. Since the preparation of the 1997 final EIS and the 2005 final supplemental EIS, congressional mandates have resulted in expansions to FDA's programs and GSA is updating the FDA Headquarters Master Plan to accommodate additional growth on the 130-acre campus. The plan is based on grouping buildings for the six FDA research and administrative functions around a central campus that serves to unite the functions and link the campus to the woodlands to the east. Three alternatives, including a No Action Alternative, are considered in this draft supplemental EIS. The proposed action would construct facilities to accommodate the increase of FDA employees from 7,719 to 8,889, change the placement of a 10,000-square foot child care center, construct a 10,000-square foot fitness center, relocate the 25,000-square foot broadcast studio, expand the central utility plant by 50,000 square feet, and construct a 300,000 gallon elevated water storage tank for potable water. The proposed action would add an additional 1.3 million gross square feet of space to support FDA's mission for a total of almost 6 million square feet. Two parking spaces would be provided for every three employees while visitor parking would be increased from 500 to 1,000 spaces for a total of 6,926 parking spaces on the FDA campus. The Dispersed Density Alternative (Alternative 2) would follow existing building heights to maintain uniformity across the campus and would add a northwest parking garage. Under the Southeast Quadrant Density Alternative (Alternative 3), building heights would be greater than that of existing buildings locating most of the density in the southeastern part of the campus. POSITIVE IMPACTS: The proposed action would accommodate the projected increase in FDA personnel within the 130 acres appropriated by Congress for the FDA headquarters. Expanded office and laboratory space and the associated infrastructure improvements would allow the additional employees to conduct the complex and comprehensive reviews of new drugs and medical devices which are part of FDA's mandated programs. The use of the central utility plant would have moderate, long-term beneficial impacts to overall energy supplies. Under the action alternatives, employment would increase by 1,170 employees by 2012. NEGATIVE IMPACTS: The action proposed in this draft supplemental EIS would have moderate, long-term, adverse impacts from the clearing, grading, and construction activities that would affect soils. An erosion and sediment plan would be implemented to control and reduce sediments from entering storm drains and adjacent streams. The total impervious surface area under alternatives 2 and 3 would be increased by 5.6 and 2.9 acres, respectively, over the No Action alternative, with consequent minor, long-term, adverse effects to groundwater quality and hydrology. The proposed locations for the broadcast studio and water storage tank would have direct impacts to wetlands and associated buffers. Under the action alternatives, the FDA headquarters consolidation would continue to have moderate, long-term impacts on traffic levels with the additional employees generating approximately 777 vehicle trips in the morning and evening peak hours and improvements to several intersections would be needed. Buildings proposed under the action alternatives would adversely impact views from adjacent streets and apartment communities. The proposed water tower would have a total elevation of 471 to 476 feet and would stand more than 20 feet taller than any surrounding structure. LEGAL MANDATES: National Capital Planning Act of 1952 (40 U.S.C. 71d(a)) and National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstracts of the draft and final EISs, see 96-0183D, Volume 20, Number 2 and 97-0143F, Volume 21, Number 2, respectively. For the abstracts of previous draft and final supplemental EISs, see 05-0253D, Volume 28, Number 2 and 05-0666F, Volume 29, Number 4, respectively. JF - EPA number: 090086, Draft Supplemental EIS--224 page, Appendices--389 pages, March 20, 2009 PY - 2009 KW - Urban and Social Programs KW - Air Quality Assessments KW - Buildings KW - Employment KW - Forests KW - Health Hazard KW - Land Use KW - Noise Assessments KW - Parking KW - Public Health KW - Research Facilities KW - Site Planning KW - Traffic Analyses KW - Water Storage KW - Maryland KW - National Historic Preservation Act of 1966, Historic Sites KW - National Capital Planning Act of 1952, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36344705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28DRAFT+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+April+1997%29.&rft.title=U.S.+FOOD+AND+DRUG+ADMINISTRATION+HEADQUARTERS+CONSOLIDATION%2C+MONTGOMERY+COUNTY%2C+MARYLAND+%28DRAFT+SUPPLEMENT+TO+THE+FINAL+ENVIRONMENTAL+IMPACT+STATEMENT+OF+April+1997%29.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - General Services Administration, Washington, District of Columbia; GSA N1 - Date revised - 2009-07-16 N1 - SuppNotes - Draft. Preparation date: March 20, 2009 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Aspirin for the primary prevention of cardiovascular events: an update of the evidence for the U.S. Preventive Services Task Force. AN - 67036952; 19293073 AB - Coronary heart disease and cerebrovascular disease are leading causes of death in the United States. In 2002, the U.S. Preventive Services Task Force (USPSTF) strongly recommended that clinicians discuss aspirin with adults who are at increased risk for coronary heart disease. To determine the benefits and harms of taking aspirin for the primary prevention of myocardial infarctions, strokes, and death. MEDLINE and Cochrane Library (search dates, 1 January 2001 to 28 August 2008), recent systematic reviews, reference lists of retrieved articles, and suggestions from experts. English-language randomized, controlled trials (RCTs); case-control studies; meta-analyses; and systematic reviews of aspirin versus control for the primary prevention of cardiovascular disease (CVD) were selected to answer the following questions: Does aspirin decrease coronary heart events, strokes, death from coronary heart events or stroke, or all-cause mortality in adults without known CVD? Does aspirin increase gastrointestinal bleeding or hemorrhagic strokes? All studies were reviewed, abstracted, and rated for quality by using predefined USPSTF criteria. New evidence from 1 good-quality RCT, 1 good-quality meta-analysis, and 2 fair-quality subanalyses of RCTs demonstrates that aspirin use reduces the number of CVD events in patients without known CVD. Men in these studies experienced fewer myocardial infarctions and women experienced fewer ischemic strokes. Aspirin does not seem to affect CVD mortality or all-cause mortality in either men or women. The use of aspirin for primary prevention increases the risk for major bleeding events, primarily gastrointestinal bleeding events, in both men and women. Men have an increased risk for hemorrhagic strokes with aspirin use. A new RCT and meta-analysis suggest that the risk for hemorrhagic strokes in women is not statistically significantly increased. New evidence on aspirin for the primary prevention of CVD is limited. The dose of aspirin used in the RCTs varied, which prevented the estimation of the most appropriate dose for primary prevention. Several of the RCTs were conducted within populations of health professionals, which potentially limits generalizability. Aspirin reduces the risk for myocardial infarction in men and strokes in women. Aspirin use increases the risk for serious bleeding events. JF - Annals of internal medicine AU - Wolff, Tracy AU - Miller, Therese AU - Ko, Stephen AD - Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA. Y1 - 2009/03/17/ PY - 2009 DA - 2009 Mar 17 SP - 405 EP - 410 VL - 150 IS - 6 KW - Platelet Aggregation Inhibitors KW - 0 KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Mortality KW - Age Factors KW - Primary Prevention KW - Humans KW - Aged KW - Middle Aged KW - Gastrointestinal Hemorrhage -- chemically induced KW - Stroke -- chemically induced KW - Male KW - Female KW - Risk Assessment KW - Platelet Aggregation Inhibitors -- adverse effects KW - Platelet Aggregation Inhibitors -- therapeutic use KW - Aspirin -- adverse effects KW - Aspirin -- therapeutic use KW - Cardiovascular Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67036952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Aspirin+for+the+primary+prevention+of+cardiovascular+events%3A+an+update+of+the+evidence+for+the+U.S.+Preventive+Services+Task+Force.&rft.au=Wolff%2C+Tracy%3BMiller%2C+Therese%3BKo%2C+Stephen&rft.aulast=Wolff&rft.aufirst=Tracy&rft.date=2009-03-17&rft.volume=150&rft.issue=6&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-08 N1 - Date created - 2009-03-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Summary For Patients In: Ann Intern Med. 2009 Mar 17;150(6):I-37 [19293068] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of an HPLC-MS procedure for the quantification of N-acetyl-S-(n-propyl)-l-cysteine, the major urinary metabolite of 1-bromopropane in human urine. AN - 67002426; 19237326 AB - An analytical procedure was developed for the detection and quantification of N-acetyl-S-(n-propyl)-l-cysteine (n-propylmercapturic acid, AcPrCys), a metabolite and biomarker for exposure to 1-bromopropane (1-BP). 1-BP is used as an industrial solvent and exposure is a health concern for industrial workers due to its toxicity. It has been associated with neurological disorders in both animals and humans. Urine sample preparation for the determination of AcPrCys consisted of solid phase extraction (SPE). Urine samples on preconditioned SPE (C18) columns were washed with 40% methanol/60% water solution prior to elution with acetone. Quantification was by means of a liquid chromatograph (LC) equipped with a mass spectrometer (MS) using an Aqua 3 microm C18 300A column and [d(7)]-AcPrCys was used as internal standard. Electrospray ionization (ESI) was used with the MS operated in the negative ion mode and selected ion monitoring (SIM) at m/z 204 for AcPrCys and m/z 211 for [d(7)]-AcPrCys. Demonstrated recovery of urine samples fortified at multiple levels (0.625-10 microg/ml) varied between 96 and 103% of theory with relative standard deviations (RSD) of 6.4% or less. The limit of detection (LOD) for the procedure was approximately 0.01 microg/ml AcPrCys in urine. These data will be discussed as well as other factors of the development of this test procedure. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Cheever, K L AU - Marlow, K L AU - B'hymer, C AU - Hanley, K W AU - Lynch, D W AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health 4676 Columbia Parkway, Cincinnati, OH 45226, USA. Y1 - 2009/03/15/ PY - 2009 DA - 2009 Mar 15 SP - 827 EP - 832 VL - 877 IS - 8-9 KW - Hydrocarbons, Brominated KW - 0 KW - N-acetyl-S-propylcysteine KW - Acetylcysteine KW - WYQ7N0BPYC KW - 1-bromopropane KW - Y9746DNE68 KW - Index Medicus KW - Hydrocarbons, Brominated -- urine KW - Humans KW - Acetylcysteine -- urine KW - Acetylcysteine -- analogs & derivatives KW - Chromatography, High Pressure Liquid -- methods KW - Mass Spectrometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67002426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Development+of+an+HPLC-MS+procedure+for+the+quantification+of+N-acetyl-S-%28n-propyl%29-l-cysteine%2C+the+major+urinary+metabolite+of+1-bromopropane+in+human+urine.&rft.au=Cheever%2C+K+L%3BMarlow%2C+K+L%3BB%27hymer%2C+C%3BHanley%2C+K+W%3BLynch%2C+D+W&rft.aulast=Cheever&rft.aufirst=K&rft.date=2009-03-15&rft.volume=877&rft.issue=8-9&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=1873-376X&rft_id=info:doi/10.1016%2Fj.jchromb.2009.02.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-07 N1 - Date created - 2009-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jchromb.2009.02.010 ER - TY - JOUR T1 - The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation. AN - 66983257; 19167416 AB - The aromatic amine 2-acetylaminofluore (2-AAF) is a powerful complete genotoxic rat liver carcinogen that induces tumors without any additional interventions. While the tumor-initiating genotoxic activity of 2-AAF is well established, its tumor-promotion activity is far less understood. It is believed that the tumor-promoting property of 2-AAF is associated with selective enhancement of cell replication and sustained suppression of apoptosis in initiated cells. In the present study, we investigated the underlying mechanisms of tumor-promoting events induced by 2-AAF-exposure. Male Sprague-Dawley rats were fed NIH-31 diet containing 0.02% of 2-AAF for 12 and 24 weeks, and the expression pattern of genes associated with the p53-signaling pathway and microRNA genes was determined in the livers of control and 2-AAF-fed rats. The results indicate that the tumor-promoting property of 2-AAF during hepatocarcinogenesis is associated predominantly with the up-regulation of anti-apoptotic growth-related genes and down-regulation of expression of pro-apoptotic genes. This disrupts the balance between cell proliferation and apoptosis, which leads to consequential unrestricted cell proliferation, especially of initiated cells. Also, the long-term-administration of 2-AAF resulted in disruption of regulatory miR-34a-p53 feed-back loop that mediates apoptosis. This was evidenced by an increased expression of miR-34a in response to genotoxic effects of 2-AAF in the absence of p53 up-regulation, and loss of regulatory control of mir-34a on SIRT1 function. Additionally, the livers of 2-AAF-exposed rats were characterized by the substantial deregulation of expression of miR-18, miR-21, miR-182, and miR-200 family, microRNAs involved in control of apoptosis/cell proliferation and cell-cell contact pathways, two major pathways disrupted during the promotion stage of hepatocarcinogenesis. JF - Toxicology and applied pharmacology AU - Pogribny, Igor P AU - Muskhelishvili, Levan AU - Tryndyak, Volodymyr P AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. igor.pogribny@fda.hhs.gov Y1 - 2009/03/15/ PY - 2009 DA - 2009 Mar 15 SP - 305 EP - 311 VL - 235 IS - 3 KW - Carcinogens KW - 0 KW - MIRN182 microRNA, rat KW - MicroRNAs KW - Tumor Suppressor Protein p53 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Liver Neoplasms, Experimental -- pathology KW - MicroRNAs -- genetics KW - Liver Neoplasms, Experimental -- metabolism KW - Liver Neoplasms, Experimental -- chemically induced KW - Male KW - Cell Proliferation -- drug effects KW - Signal Transduction -- physiology KW - 2-Acetylaminofluorene -- administration & dosage KW - Tumor Suppressor Protein p53 -- antagonists & inhibitors KW - 2-Acetylaminofluorene -- toxicity KW - Carcinogens -- administration & dosage KW - Apoptosis -- physiology KW - Signal Transduction -- drug effects KW - Apoptosis -- drug effects KW - Carcinogens -- toxicity KW - Tumor Suppressor Protein p53 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66983257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=The+tumor-promoting+activity+of+2-acetylaminofluorene+is+associated+with+disruption+of+the+p53+signaling+pathway+and+the+balance+between+apoptosis+and+cell+proliferation.&rft.au=Pogribny%2C+Igor+P%3BMuskhelishvili%2C+Levan%3BTryndyak%2C+Volodymyr+P%3BBeland%2C+Frederick+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2009-03-15&rft.volume=235&rft.issue=3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2008.12.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2009-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2008.12.021 ER - TY - JOUR T1 - Radon exposure and mortality among white and American Indian uranium miners: an update of the Colorado Plateau cohort. AN - 66972631; 19208723 AB - Studies of uranium miners on the US Colorado Plateau have identified associations between exposure to radon progeny and risk of lung cancer. This study added 15 years of mortality follow-up for the 4,137 miners (primarily white or American Indian) in the Colorado Plateau cohort. The cohort experienced 209 new lung cancer deaths. For white miners, the standardized mortality ratio for lung cancer compared with the regional population was 3.99 (95% confidence interval: 3.43, 4.62) for the period 1991-2005. For American Indian miners, the lung cancer standardized mortality ratio was 3.27 (95% confidence interval: 2.19, 4.73). These standardized mortality ratios have not declined substantially since the 1980s. Internally standardized rate ratios by radon exposure category over the entire follow-up period are similar to those based on earlier follow-up, although estimates within smoking categories demonstrated improved precision. The apparent interaction between radon and smoking in causing lung cancer remains submultiplicative but greater than additive. Mortality rates from silicosis remain highly elevated in the cohort. Elevated mortality rates were observed from interstitial pulmonary fibrosis, multiple myeloma, and non-Hodgkin lymphoma. Significant trends were observed with increased radon exposure in silicosis and pulmonary fibrosis mortality and in the incidence of diabetes-related end-stage renal disease among white miners. JF - American journal of epidemiology AU - Schubauer-Berigan, Mary K AU - Daniels, Robert D AU - Pinkerton, Lynne E AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. zcg3@cdc.gov Y1 - 2009/03/15/ PY - 2009 DA - 2009 Mar 15 SP - 718 EP - 730 VL - 169 IS - 6 KW - Uranium KW - 4OC371KSTK KW - Radon KW - Q74S4N8N1G KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Incidence KW - Poisson Distribution KW - Colorado -- epidemiology KW - Male KW - Cause of Death KW - Occupational Exposure -- adverse effects KW - European Continental Ancestry Group -- statistics & numerical data KW - Mining KW - Indians, North American -- statistics & numerical data KW - Radon -- toxicity KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66972631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Radon+exposure+and+mortality+among+white+and+American+Indian+uranium+miners%3A+an+update+of+the+Colorado+Plateau+cohort.&rft.au=Schubauer-Berigan%2C+Mary+K%3BDaniels%2C+Robert+D%3BPinkerton%2C+Lynne+E&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2009-03-15&rft.volume=169&rft.issue=6&rft.spage=718&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwn406 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-16 N1 - Date created - 2009-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwn406 ER - TY - JOUR T1 - IL-13 cytotoxin has potent antitumor activity and synergizes with paclitaxel in a mouse model of oral squamous cell carcinoma. AN - 66826816; 19065664 AB - Interleukin-13 receptor-targeted cytotoxin (IL13-PE38) is highly cytotoxic to certain types of human cancers expressing abundant levels of IL-13Ralpha2 chain. Although IL13-PE38 is being tested in a Phase III clinical trial in brain tumors, the activity of IL13-PE38 alone or when combined with taxane, a chemotherapeutic drug for oral squamous cell carcinoma (OSCC), has not been investigated. Here, we show that approximately 40% of OSCCs (n = 50) in a tissue array are strongly positive for IL-13Ralpha2, whereas normal oral mucosa (n = 10) expresses very low or undetectable levels evaluated by immunohistochemistry. IL13-PE38 was highly cytotoxic to OSCC cell lines, but not cytotoxic to normal oral fibroblasts. IL13-PE38 mediated a synergistic antitumor effect with paclitaxel in OSC-19 in vitro and in vivo in the orthotopic OSCC tongue tumor model. Real-time tumor growth was monitored by optical imaging using a Xenogen-IVIS imaging system. Treated animals showed significant (p < 0.05) improvement in survival, which correlated with in vivo imaging of tumor response without evidence of visible toxicity. Gene transfer of IL-13Ralpha2 in oral cancer cells increased sensitivity of OSCC cell line to IL13-PE38 in vitro. Retrovirus-mediated gene-transfer of IL-13Ralpha2 in HSC-3 into tongue tumors in vivo dramatically enhanced the antitumor activity of IL13-PE38, providing complete elimination of established tumors and prolonging survival of these animals. These results indicate that IL13-PE38 in combination with paclitaxel acting via different mechanisms may be a potential treatment option for IL-13Ralpha2 expressing OSCC or for the treatment of non-IL-13Ralpha2 expressing OSCC combined with gene transfer of IL-13Ralpha2. JF - International journal of cancer AU - Kioi, Mitomu AU - Shimamura, Takeshi AU - Nakashima, Hideyuki AU - Hirota, Makoto AU - Tohnai, Iwai AU - Husain, Syed R AU - Puri, Raj K AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2009/03/15/ PY - 2009 DA - 2009 Mar 15 SP - 1440 EP - 1448 VL - 124 IS - 6 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Exotoxins KW - IL13-PE38 KW - Interleukin-13 KW - Recombinant Fusion Proteins KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Animals KW - Humans KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Transplantation, Heterologous KW - Tongue Neoplasms -- drug therapy KW - Disease Models, Animal KW - Mice KW - Cell Line, Tumor KW - Reverse Transcriptase Polymerase Chain Reaction KW - Drug Synergism KW - Interleukin-13 -- therapeutic use KW - Carcinoma, Squamous Cell -- genetics KW - Paclitaxel -- therapeutic use KW - Mouth Neoplasms -- drug therapy KW - Exotoxins -- therapeutic use KW - Recombinant Fusion Proteins -- therapeutic use KW - Carcinoma, Squamous Cell -- drug therapy KW - Mouth Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66826816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=IL-13+cytotoxin+has+potent+antitumor+activity+and+synergizes+with+paclitaxel+in+a+mouse+model+of+oral+squamous+cell+carcinoma.&rft.au=Kioi%2C+Mitomu%3BShimamura%2C+Takeshi%3BNakashima%2C+Hideyuki%3BHirota%2C+Makoto%3BTohnai%2C+Iwai%3BHusain%2C+Syed+R%3BPuri%2C+Raj+K&rft.aulast=Kioi&rft.aufirst=Mitomu&rft.date=2009-03-15&rft.volume=124&rft.issue=6&rft.spage=1440&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.24067 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-23 N1 - Date created - 2009-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.24067 ER - TY - RPRT T1 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN, NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. [Part 1 of 1] T2 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN, NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. AN - 756824918; 13803-090078_0001 AB - PURPOSE: The adoption of an updated master development plan for the Rocky Mountain Laboratories (RML) campus of the National Institutes of Health (NIH) Main Campus in Hamilton, Ravalli County, Montana is proposed. The primary mission of NIH is to expand fundamental knowledge about the nature and behavior or living systems, to apply that knowledge to enhance the health of humans, and to reduce the burdens of disease and disability. If adopted, the proposed 20-year master plan, which would be reviewed quinquennially, would constitute part of a broad, long-term planning effort at the Department of Health and Human Services (HHS) and would fulfill a requirement of all HHS-administered campuses. The plan would provide a strategy for accommodating potential RML campus development subject to NIH and HHS priorities and the availability of resources. It also would serve as a guide for the development of individual projects, and assist local jurisdictions and utilities in anticipating and planning for infrastructure and systems as they relate to the needs of the RML. It would guide and coordinate the physical development of the RML campus with respect to siting of future construction, vehicular and pedestrian circulation on and off-campus, parking within the property boundaries, open space in and around the campus, required setbacks, historic properties management, natural and scenic resources, and noise and lighting; these considerations would respond to projected NIH administrative, research, and infrastructure support needs. Programming of future campus personnel and facilities was determined through an extensive series of interviews with NIH management and individual institute and center directorates. Three alternatives, including a No Action Alternative, which would retain the existing master plan and complete ongoing projects, are considered in this final EIS. The proposed Alternative would expand the campus from 33 acres to 36 acres, expand the extent of developed areas from nine acres to 17 acres, and expand the occupiable building area from 323,805 gross square feet to 445,713 gross square feet. The principal features of the master plan would provide for campus upgrades, such as the demolition and replacement of obsolete buildings; construction of a central administration and storage building, which would represent much of the building area growth; expansion of parking facilities from a capacity of 400 spaces to a capacity of 461 spaces; modification of the Fifth Street access point; construction of a new long-term storage facility; installation of a new expanded perimeter fence; creation of a pedestrian core at the center of campus; and provision of landscaped open space throughout campus. POSITIVE IMPACTS: Plan implementation would significantly enhance the functional and social aspects of the NIH Bethesda Campus. Research facilities would be significantly upgraded and facility inadequacies would be corrected. The modified transportation system would provide enhanced access within the campus, and landscaping and other aesthetic improvements would transform the somewhat dysfunctional campus into a pleasing and functionally adequate workplace. Utility line conflicts would be resolved. NEGATIVE IMPACTS: The extent of open, undisturbed area would decline from 24 acres to 19 acres. Increases in personnel using the site would place additional stress on the local transportation system within and outside the campus, utilities and waste management facilities, and energy sources. Construction activities, demolition of historically significant buildings, and new buildings and infrastructure would alter the visual appearance of the RML Historic District. LEGAL MANDATES: National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstract of the draft EIS, see 08-0478D, Volume 32, Number 4. JF - EPA number: 090078, 110 pages, March 13, 2009 PY - 2009 VL - 1 KW - Research and Development KW - Buildings KW - Demolition KW - Employment KW - Historic Districts KW - Historic Sites KW - Open Space KW - Parking KW - Research Facilities KW - Roads KW - Storage KW - Transportation KW - Vegetation KW - Visual Resources KW - Montana KW - National Historic Preservation Act of 1966, Historic Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756824918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-03-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=ROCKY+MOUNTAIN+LABORATORIES+MASTER+PLAN%2C+NATIONAL+INSTITUTES+OF+HEALTH%2C+HAMILTON%2C+RAVALLI+COUNTY%2C+MONTANA.&rft.title=ROCKY+MOUNTAIN+LABORATORIES+MASTER+PLAN%2C+NATIONAL+INSTITUTES+OF+HEALTH%2C+HAMILTON%2C+RAVALLI+COUNTY%2C+MONTANA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2009-07-16 N1 - SuppNotes - Final. Preparation date: March 13, 2009 N1 - Last updated - 2011-12-16 ER - TY - RPRT T1 - ROCKY MOUNTAIN LABORATORIES MASTER PLAN, NATIONAL INSTITUTES OF HEALTH, HAMILTON, RAVALLI COUNTY, MONTANA. AN - 16377488; 13803 AB - PURPOSE: The adoption of an updated master development plan for the Rocky Mountain Laboratories (RML) campus of the National Institutes of Health (NIH) Main Campus in Hamilton, Ravalli County, Montana is proposed. The primary mission of NIH is to expand fundamental knowledge about the nature and behavior or living systems, to apply that knowledge to enhance the health of humans, and to reduce the burdens of disease and disability. If adopted, the proposed 20-year master plan, which would be reviewed quinquennially, would constitute part of a broad, long-term planning effort at the Department of Health and Human Services (HHS) and would fulfill a requirement of all HHS-administered campuses. The plan would provide a strategy for accommodating potential RML campus development subject to NIH and HHS priorities and the availability of resources. It also would serve as a guide for the development of individual projects, and assist local jurisdictions and utilities in anticipating and planning for infrastructure and systems as they relate to the needs of the RML. It would guide and coordinate the physical development of the RML campus with respect to siting of future construction, vehicular and pedestrian circulation on and off-campus, parking within the property boundaries, open space in and around the campus, required setbacks, historic properties management, natural and scenic resources, and noise and lighting; these considerations would respond to projected NIH administrative, research, and infrastructure support needs. Programming of future campus personnel and facilities was determined through an extensive series of interviews with NIH management and individual institute and center directorates. Three alternatives, including a No Action Alternative, which would retain the existing master plan and complete ongoing projects, are considered in this final EIS. The proposed Alternative would expand the campus from 33 acres to 36 acres, expand the extent of developed areas from nine acres to 17 acres, and expand the occupiable building area from 323,805 gross square feet to 445,713 gross square feet. The principal features of the master plan would provide for campus upgrades, such as the demolition and replacement of obsolete buildings; construction of a central administration and storage building, which would represent much of the building area growth; expansion of parking facilities from a capacity of 400 spaces to a capacity of 461 spaces; modification of the Fifth Street access point; construction of a new long-term storage facility; installation of a new expanded perimeter fence; creation of a pedestrian core at the center of campus; and provision of landscaped open space throughout campus. POSITIVE IMPACTS: Plan implementation would significantly enhance the functional and social aspects of the NIH Bethesda Campus. Research facilities would be significantly upgraded and facility inadequacies would be corrected. The modified transportation system would provide enhanced access within the campus, and landscaping and other aesthetic improvements would transform the somewhat dysfunctional campus into a pleasing and functionally adequate workplace. Utility line conflicts would be resolved. NEGATIVE IMPACTS: The extent of open, undisturbed area would decline from 24 acres to 19 acres. Increases in personnel using the site would place additional stress on the local transportation system within and outside the campus, utilities and waste management facilities, and energy sources. Construction activities, demolition of historically significant buildings, and new buildings and infrastructure would alter the visual appearance of the RML Historic District. LEGAL MANDATES: National Historic Preservation Act of 1966 (16 U.S.C. 470 et seq.). PRIOR REFERENCES: For the abstract of the draft EIS, see 08-0478D, Volume 32, Number 4. JF - EPA number: 090078, 110 pages, March 13, 2009 PY - 2009 KW - Research and Development KW - Buildings KW - Demolition KW - Employment KW - Historic Districts KW - Historic Sites KW - Open Space KW - Parking KW - Research Facilities KW - Roads KW - Storage KW - Transportation KW - Vegetation KW - Visual Resources KW - Montana KW - National Historic Preservation Act of 1966, Historic Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16377488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-03-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=ROCKY+MOUNTAIN+LABORATORIES+MASTER+PLAN%2C+NATIONAL+INSTITUTES+OF+HEALTH%2C+HAMILTON%2C+RAVALLI+COUNTY%2C+MONTANA.&rft.title=ROCKY+MOUNTAIN+LABORATORIES+MASTER+PLAN%2C+NATIONAL+INSTITUTES+OF+HEALTH%2C+HAMILTON%2C+RAVALLI+COUNTY%2C+MONTANA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2009-07-16 N1 - SuppNotes - Final. Preparation date: March 13, 2009 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Difference in Phototoxicity of Cyclodextrin Complexed Fullerene [(*g-CyD)2/C60] and Its Aggregated Derivatives toward Human Lens Epithelial Cells AN - 754547101; 13301028 AB - The water-soluble fullerene derivative *g-cyclodextrin bicapped C60 [(*g-CyD)2/C60, CDF0] has several clinical applications, including use as a drug carrier to bypass the blood ocular barriers or a photosensitizer to treat tumors in photodynamic therapy. We have assessed the potential ocular toxicity of (*g-CyD)2/C60 and its aggregated derivatives induced by UVA and visible light in vitro in human lens epithelial cells (HLE B-3). Cell viability using the MTS assay demonstrated that 2 *mM (*g-CyD)2/C60 was highly phototoxic to HLE B-3 cells with UVA irradiation, while no effect was observed in the presence of visible light or when maintained in the dark. In contrast, the aggregated derivative (CDF150) showed neither cytotoxicity nor any phototoxic effect even at 30 *mM with either UVA or visible light irradiation. In lens cells treated with (*g-CyD)2/C60, phototoxicity was manifested as apoptosis. Singlet oxygen production measurement using the EPR/TEMP trapping technique determined that (*g-CyD)2/C60 (CDF0) efficiently produced singlet oxygen. The rate of singlet oxygen production decreased with increased aggregation, with no production by the fully aggregated sample formed after 150 min of heating (CDF150). UVA irradiation of HLE B-3 in the presence of (*g-CyD)2/C60 resulted in a significant rise in intracellular protein-derived peroxides. The singlet oxygen quenchers sodium azide and histidine each significantly protected lens cells against (*g-CyD)2/C60 photodamage, but lutein and Trolox (vitamin E) did not. Clearly, singlet oxygen is an important intermediate in the phototoxicity of monomeric (*g-CyD)2/fullerene. Our results also demonstrate that UVA-blocking sunglasses can limit the ocular phototoxicity of this nanomaterial, while nontoxic endogenous antioxidants like lutein or Trolox cannot provide adequate protection. JF - Chemical Research in Toxicology AU - Zhao, Baozhong AU - He, Yu-Ying AU - Chignell, Colin F AU - Yin, Jun-Jie AU - Andley, Usha AU - Roberts, Joan E AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740, Department of Ophthalmology and Visual Science, Washington University School of Medicine, St. Louis, Missouri 63110, and Department of Natural Sciences, Fordham University, 113 West 60th Street, New York City, New York 10023 Y1 - 2009/03/12/ PY - 2009 DA - 2009 Mar 12 SP - 660 EP - 667 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA VL - 22 IS - 4 SN - 0893-228X, 0893-228X KW - Toxicology Abstracts KW - Epithelial cells KW - Drug delivery KW - Sodium azide KW - Apoptosis KW - Antioxidants KW - photodynamic therapy KW - Therapeutic applications KW - Toxicity KW - Tumors KW - Trapping KW - Light effects KW - Phototoxicity KW - Oxygen KW - Blood KW - Vitamin E KW - Cytotoxicity KW - cyclodextrin KW - U.V. radiation KW - Fullerenes KW - Radiation KW - Histidine KW - peroxide KW - Xanthophyll KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754547101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Difference+in+Phototoxicity+of+Cyclodextrin+Complexed+Fullerene+%5B%28*g-CyD%292%2FC60%5D+and+Its+Aggregated+Derivatives+toward+Human+Lens+Epithelial+Cells&rft.au=Zhao%2C+Baozhong%3BHe%2C+Yu-Ying%3BChignell%2C+Colin+F%3BYin%2C+Jun-Jie%3BAndley%2C+Usha%3BRoberts%2C+Joan+E&rft.aulast=Zhao&rft.aufirst=Baozhong&rft.date=2009-03-12&rft.volume=22&rft.issue=4&rft.spage=660&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx800478u LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Drug delivery; Epithelial cells; Sodium azide; Antioxidants; Apoptosis; photodynamic therapy; Therapeutic applications; Tumors; Toxicity; Trapping; Light effects; Phototoxicity; Blood; Oxygen; Cytotoxicity; Vitamin E; U.V. radiation; cyclodextrin; Radiation; Fullerenes; Histidine; peroxide; Xanthophyll DO - http://dx.doi.org/10.1021/tx800478u ER - TY - JOUR T1 - Investigation of reproducibility of differentially expressed genes in DNA microarrays through statistical simulation. AN - 733319665; 19278560 AB - Recent publications have raised concerns about the reliability of microarray technology because of the lack of reproducibility of differentially expressed genes (DEGs) from highly similar studies across laboratories and platforms. The rat toxicogenomics study of the MicroArray Quality Control (MAQC) project empirically revealed that the DEGs selected using a fold change (FC)-based criterion were more reproducible than those derived solely by statistical significance such as P-value from a simple t-tests. In this study, we generate a set of simulated microarray datasets to compare gene selection/ranking rules, including P-value, FC and their combinations, using the percentage of overlapping genes between DEGs from two similar simulated datasets as the measure of reproducibility. The results are supportive of the MAQC's conclusion on that DEG lists are more reproducible across laboratories and platforms when FC-based ranking coupled with a nonstringent P-value cutoff is used for gene selection compared with selection based on P-value based ranking method. We conclude that the MAQC recommendation should be considered when reproducibility is an important study objective. JF - BMC proceedings AU - Fan, Xiaohui AU - Shi, Leming AU - Fang, Hong AU - Harris, Stephen AU - Perkins, Roger AU - Tong, Weida AD - National Center for Toxicological Research (NCTR), US Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA. fanxh@zju.edu.cn Y1 - 2009/03/10/ PY - 2009 DA - 2009 Mar 10 SP - 1 VL - 3 Suppl 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733319665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+proceedings&rft.atitle=Investigation+of+reproducibility+of+differentially+expressed+genes+in+DNA+microarrays+through+statistical+simulation.&rft.au=Fan%2C+Xiaohui%3BShi%2C+Leming%3BFang%2C+Hong%3BHarris%2C+Stephen%3BPerkins%2C+Roger%3BTong%2C+Weida&rft.aulast=Fan&rft.aufirst=Xiaohui&rft.date=2009-03-10&rft.volume=3+Suppl+2&rft.issue=&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=BMC+proceedings&rft.issn=1753-6561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-15 N1 - Date created - 2009-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMC Bioinformatics. 2008;9 Suppl 9:S10 [18793455] Nat Biotechnol. 2006 Sep;24(9):1162-9 [17061323] Nat Biotechnol. 2006 Sep;24(9):1151-61 [16964229] J Natl Cancer Inst. 2006 Sep 6;98(17):1169-71 [16954463] N Engl J Med. 2006 Aug 10;355(6):560-9 [16899776] Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5923-8 [16585533] Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13790-5 [11707567] Lancet. 2005 Feb 5-11;365(9458):488-92 [15705458] Science. 2004 Oct 22;306(5696):630-1 [15499004] Lancet. 2003 Mar 15;361(9361):923-9 [12648972] N Engl J Med. 2002 Jun 20;346(25):1937-47 [12075054] Nature. 2002 Jan 31;415(6871):530-6 [11823860] Nature. 2002 Jan 24;415(6870):436-42 [11807556] PLoS Med. 2005 Aug;2(8):e124 [16060722] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - ebTrack: an environmental bioinformatics system built upon ArrayTrack. AN - 733319376; 19278561 AB - ebTrack is being developed as an integrated bioinformatics system for environmental research and analysis by addressing the issues of integration, curation, management, first level analysis and interpretation of environmental and toxicological data from diverse sources. It is based on enhancements to the US FDA developed ArrayTrack system through additional analysis modules for gene expression data as well as through incorporation and linkages to modules for analysis of proteomic and metabonomic datasets that include tandem mass spectra. ebTrack uses a client-server architecture with the free and open source PostgreSQL as its database engine, and java tools for user interface, analysis, visualization, and web-based deployment. Several predictive tools that are critical for environmental health research are currently supported in ebTrack, including Significance Analysis of Microarray (SAM). Furthermore, new tools are under continuous integration, and interfaces to environmental health risk analysis tools are being developed in order to make ebTrack widely usable. These health risk analysis tools include the Modeling ENvironment for TOtal Risk studies (MENTOR) for source-to-dose exposure modeling and the DOse Response Information ANalysis system (DORIAN) for health outcome modeling. The design of ebTrack is presented in detail and steps involved in its application are summarized through an illustrative application. JF - BMC proceedings AU - Chen, Minjun AU - Martin, Jackson AU - Fang, Hong AU - Isukapalli, Sastry AU - Georgopoulos, Panos G AU - Welsh, William J AU - Tong, Weida AD - Department of Environmental and Occupational Medicine, UMDNJ-RWJMS, 675 Hoes Lane, Piscataway, NJ 08854, USA. minjun.chen@fda.hhs.gov Y1 - 2009/03/10/ PY - 2009 DA - 2009 Mar 10 SP - 1 VL - 3 Suppl 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733319376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+proceedings&rft.atitle=ebTrack%3A+an+environmental+bioinformatics+system+built+upon+ArrayTrack.&rft.au=Chen%2C+Minjun%3BMartin%2C+Jackson%3BFang%2C+Hong%3BIsukapalli%2C+Sastry%3BGeorgopoulos%2C+Panos+G%3BWelsh%2C+William+J%3BTong%2C+Weida&rft.aulast=Chen&rft.aufirst=Minjun&rft.date=2009-03-10&rft.volume=3+Suppl+2&rft.issue=&rft.spage=S5&rft.isbn=&rft.btitle=&rft.title=BMC+proceedings&rft.issn=1753-6561&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-15 N1 - Date created - 2009-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Expo Sci Environ Epidemiol. 2009 Feb;19(2):149-71 [18368010] J Expo Sci Environ Epidemiol. 2008 Sep;18(5):462-76 [18073786] Physiol Genomics. 2008 Feb 19;32(3):283-98 [17911379] Annu Rev Pharmacol Toxicol. 2007;47:357-400 [17067280] Chem Biol. 2004 Feb;11(2):161-71 [15123278] Annu Rev Pharmacol Toxicol. 2004;44:111-36 [14744241] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21 [11309499] Environ Health Perspect. 2003 Nov;111(15):1819-26 [14630514] EHP Toxicogenomics. 2003 Jan;111(1T):15-28 [12735106] Genome Biol. 2002 Aug 23;3(9):RESEARCH0046 [12225585] Nucleic Acids Res. 2002 Jan 1;30(1):207-10 [11752295] Nat Genet. 2001 Dec;29(4):365-71 [11726920] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D277-80 [14681412] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stir bar sorptive extraction-gas chromatography-mass spectrometry analysis of tetramethylene disulfotetramine in food: Method development and comparison to solid-phase microextraction. AN - 66927190; 19216873 AB - A stir bar sorptive extraction-gas chromatography-mass spectrometry (SBSE-GC-MS) method for the determination of tetramethylene disulfotetramine is presented. The limits of detection (LOD) of the optimized method was 0.2ngg(-1) for extractions from water and 0.3-2.1ngg(-1) for extractions from foods. Recovery was highly matrix dependent (36-130%) and quantification required standard addition calibrations. Standard addition calibration lines had high linearity (R(2)>0.97) and replicate extractions had good reproducibility (R.S.D.=4.4-9.8%). A comparison of the SBSE method and a previously developed headspace (HS)-solid-phase microextraction (SPME) method was performed. Generally, SBSE provided higher sensitivity with decreased analysis time. JF - Analytica chimica acta AU - De Jager, Lowri S AU - Perfetti, Gracia A AU - Diachenko, Gregory W AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA. lowri.dejager@fda.hhs.gov Y1 - 2009/03/09/ PY - 2009 DA - 2009 Mar 09 SP - 162 EP - 166 VL - 635 IS - 2 KW - Bridged-Ring Compounds KW - 0 KW - tetramethylenedisulfotetramine KW - F6TS3WME05 KW - Index Medicus KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Food Contamination -- analysis KW - Food Analysis -- methods KW - Gas Chromatography-Mass Spectrometry -- methods KW - Bridged-Ring Compounds -- isolation & purification KW - Solid Phase Microextraction -- methods KW - Bridged-Ring Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66927190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+chimica+acta&rft.atitle=Stir+bar+sorptive+extraction-gas+chromatography-mass+spectrometry+analysis+of+tetramethylene+disulfotetramine+in+food%3A+Method+development+and+comparison+to+solid-phase+microextraction.&rft.au=De+Jager%2C+Lowri+S%3BPerfetti%2C+Gracia+A%3BDiachenko%2C+Gregory+W&rft.aulast=De+Jager&rft.aufirst=Lowri&rft.date=2009-03-09&rft.volume=635&rft.issue=2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Analytica+chimica+acta&rft.issn=1873-4324&rft_id=info:doi/10.1016%2Fj.aca.2008.12.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-31 N1 - Date created - 2009-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.aca.2008.12.048 ER - TY - CPAPER T1 - Characterization of a Nitrofurazone Biomarker in Channel Catfish (Ictalurus punctatus) T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41820161; 5041209 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Wang, Yuesong AU - Jester, Edward AU - El Said, Kathleen AU - Abraham, Ann AU - Hooe-Rollman, Jennifer AU - Plakas, Steven Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Bioindicators KW - Biomarkers KW - Freshwater fish KW - Ictalurus punctatus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41820161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=Characterization+of+a+Nitrofurazone+Biomarker+in+Channel+Catfish+%28Ictalurus+punctatus%29&rft.au=Wang%2C+Yuesong%3BJester%2C+Edward%3BEl+Said%2C+Kathleen%3BAbraham%2C+Ann%3BHooe-Rollman%2C+Jennifer%3BPlakas%2C+Steven&rft.aulast=Wang&rft.aufirst=Yuesong&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Throughput Analysis in the Pharmaceutical Field T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41812890; 5040800 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Wang, Perry Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Pharmaceuticals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41812890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=High+Throughput+Analysis+in+the+Pharmaceutical+Field&rft.au=Wang%2C+Perry&rft.aulast=Wang&rft.aufirst=Perry&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elemental Speciation in Consumer Products T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41808601; 5039644 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Heitkemper, Douglas Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Consumer products KW - Speciation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41808601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=Elemental+Speciation+in+Consumer+Products&rft.au=Heitkemper%2C+Douglas&rft.aulast=Heitkemper&rft.aufirst=Douglas&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Surface Plasmon Resonance Biosensors for Improved Detection of Saxitoxin Congeners T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41806867; 5041450 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Yakes, Betsy AU - Poli, Mark AU - Hall, Sherwood AU - Etheridge, Stacey Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Biosensors KW - Surface plasmon resonance KW - Saxitoxin KW - Congeners KW - Resonance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41806867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=Surface+Plasmon+Resonance+Biosensors+for+Improved+Detection+of+Saxitoxin+Congeners&rft.au=Yakes%2C+Betsy%3BPoli%2C+Mark%3BHall%2C+Sherwood%3BEtheridge%2C+Stacey&rft.aulast=Yakes&rft.aufirst=Betsy&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantification of Silica in Coal Dust through X-Ray Fluorescence and Infrared Spectroscopy Techniques T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41799254; 5041973 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Hodge, Karma AU - Volkwein, John AU - Noll, James Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Coal KW - Dust KW - I.R. spectroscopy KW - Silica KW - Fluorescence KW - Ionizing radiation KW - Coal dust KW - Infrared spectroscopy KW - X-rays KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41799254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=Quantification+of+Silica+in+Coal+Dust+through+X-Ray+Fluorescence+and+Infrared+Spectroscopy+Techniques&rft.au=Hodge%2C+Karma%3BVolkwein%2C+John%3BNoll%2C+James&rft.aulast=Hodge&rft.aufirst=Karma&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Considerations on Product Quality of Monoclonal Antibodies T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41780528; 5039621 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Park, Jun Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Monoclonal antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41780528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=Regulatory+Considerations+on+Product+Quality+of+Monoclonal+Antibodies&rft.au=Park%2C+Jun&rft.aulast=Park&rft.aufirst=Jun&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiresidue Pesticide Analysis of Botanical Dietary Supplements T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41760472; 5041242 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Wong, Jon AU - Tech, Katherine AU - Zhang, Kai AU - Hayward, Douglas AU - Krynitsky, Alexander Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Pesticides KW - Dietary supplements KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41760472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=Multiresidue+Pesticide+Analysis+of+Botanical+Dietary+Supplements&rft.au=Wong%2C+Jon%3BTech%2C+Katherine%3BZhang%2C+Kai%3BHayward%2C+Douglas%3BKrynitsky%2C+Alexander&rft.aulast=Wong&rft.aufirst=Jon&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comprehensive Investigation Utilizing Multiple Molecular Spectroscopic Imaging / Mapping Techniques for the Analysis of Counterfeit Pharmaceuticals T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41753142; 5040221 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Lanzarotta, Adam Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Mapping KW - Imaging techniques KW - Pharmaceuticals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41753142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=A+Comprehensive+Investigation+Utilizing+Multiple+Molecular+Spectroscopic+Imaging+%2F+Mapping+Techniques+for+the+Analysis+of+Counterfeit+Pharmaceuticals&rft.au=Lanzarotta%2C+Adam&rft.aulast=Lanzarotta&rft.aufirst=Adam&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of Phosphodiesterase-5 Inhibitors and Analogs T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41751348; 5040592 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Nickum, Elisa AU - Toomey, Valerie AU - Jackson, Merrie AU - Flurer, Cheryl Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Analogs KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41751348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=Determination+of+Phosphodiesterase-5+Inhibitors+and+Analogs&rft.au=Nickum%2C+Elisa%3BToomey%2C+Valerie%3BJackson%2C+Merrie%3BFlurer%2C+Cheryl&rft.aulast=Nickum&rft.aufirst=Elisa&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Food Protection in Global Economy T2 - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AN - 41739166; 5039691 JF - 60th Pittsburgh Conference and Expo on Analytical Chemistry and Applied Spectroscopy (Pittcon 2009) AU - Musser, Steven Y1 - 2009/03/08/ PY - 2009 DA - 2009 Mar 08 KW - Economics KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41739166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.atitle=Food+Protection+in+Global+Economy&rft.au=Musser%2C+Steven&rft.aulast=Musser&rft.aufirst=Steven&rft.date=2009-03-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=60th+Pittsburgh+Conference+and+Expo+on+Analytical+Chemistry+and+Applied+Spectroscopy+%28Pittcon+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pittcon.org/technical/finalprogram.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - BOOK T1 - This Wolfe isn't in sheep's clothing. AN - 66978528; 19255086 JF - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne AU - Wolfe, Sidney Y1 - 2009/03/03/ PY - 2009 DA - 2009 Mar 03 SP - 1 EP - 584 KW - Abridged Index Medicus KW - Index Medicus KW - Wolfe KW - United States KW - United States Food and Drug Administration KW - History, 21st Century KW - Humans KW - Advisory Committees KW - Drug and Narcotic Control -- history KW - Consumer Advocacy -- history KW - Drug-Related Side Effects and Adverse Reactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66978528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/TOXLINE&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.jtitle=&rft.atitle=&rft.au=Wolfe%2C+Sidney&rft.aulast=Wolfe&rft.aufirst=Sidney&rft.date=2009-03-03&rft.volume=&rft.issue=&rft.spage=584&rft.isbn=&rft.btitle=This+Wolfe+isn%27t+in+sheep%27s+clothing.&rft.title=This+Wolfe+isn%27t+in+sheep%27s+clothing.&rft.issn=1488-2329&rft_id=info:doi/10.1503%2Fcmaj.090181 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-01 N1 - Date created - 2009-03-03 N1 - Date revised - 2017-01-13 N1 - People - Wolfe N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1503/cmaj.090181 ER - TY - JOUR T1 - Delineating Liver Events in Trichloroethylene-Induced Autoimmune Hepatitis AN - 754546897; 13301024 AB - Exposure to the environmental pollutant trichloroethylene (TCE) has been linked to autoimmune disease development in humans. Chronic (32-week) low-level exposure to TCE has been shown to promote autoimmune hepatitis in association with CD4+ T cell activation in autoimmune-prone MRL+/+ mice. MRL+/+ mice are usually thought of as a model of systemic lupus rather than an organ-specific disease such as autoimmune hepatitis. Consequently, the present study examined gene expression and metabolites to delineate the liver events that skewed the autoimmune response toward that organ in TCE-treated mice. Female MRL+/+ mice were treated with 0.5 mg/mL TCE in their drinking water. The results showed that TCE-induced autoimmune hepatitis could be detected in as little as 26 weeks. TCE exposure also generated a time-dependent increase in the number of antibodies specific for liver proteins. The gene expression correlated with the metabolite analysis to show that TCE upregulated the methionine/homocysteine pathway in the liver after 26 weeks of exposure. The results also showed that TCE exposure altered the expression of selective hepatic genes associated with immunity and inflammation. On the basis of these results, future mechanistic studies will focus on how alterations in genes associated with immunity and inflammation, in conjunction with protein alterations in the liver, promote liver immunogenicity in TCE-treated MRL+/+ mice. JF - Chemical Research in Toxicology AU - Gilbert, Kathleen M AU - Przybyla, Beata AU - Pumford, Neil R AU - Han, Tao AU - Fuscoe, James AU - Schnackenberg, Laura K AU - Holland, Ricky D AU - Doss, Jason C AU - MacMillan-Crow, Lee Ann AU - Blossom, Sarah J AD - University of Arkansas for Medical Sciences/Arkansas Children's Hospital Research Institute, Little Rock, Arkansas 72202, University of Arkansas, Fayetteville, Arkansas 72701, U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079, and University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202 Y1 - 2009/03/02/ PY - 2009 DA - 2009 Mar 02 SP - 626 EP - 632 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA VL - 22 IS - 4 SN - 0893-228X, 0893-228X KW - Toxicology Abstracts; Immunology Abstracts KW - Autoimmune diseases KW - Animal models KW - Metabolites KW - Immunity KW - Methionine KW - Cell activation KW - Inflammation KW - Gene expression KW - Hepatitis KW - CD4 antigen KW - Antibodies KW - Pollutants KW - Immunogenicity KW - Lymphocytes T KW - Liver KW - Trichloroethylene KW - Drinking water KW - homocysteine KW - F 06955:Immunomodulation & Immunopharmacology KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754546897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Delineating+Liver+Events+in+Trichloroethylene-Induced+Autoimmune+Hepatitis&rft.au=Gilbert%2C+Kathleen+M%3BPrzybyla%2C+Beata%3BPumford%2C+Neil+R%3BHan%2C+Tao%3BFuscoe%2C+James%3BSchnackenberg%2C+Laura+K%3BHolland%2C+Ricky+D%3BDoss%2C+Jason+C%3BMacMillan-Crow%2C+Lee+Ann%3BBlossom%2C+Sarah+J&rft.aulast=Gilbert&rft.aufirst=Kathleen&rft.date=2009-03-02&rft.volume=22&rft.issue=4&rft.spage=626&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx800409r LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Autoimmune diseases; Animal models; Metabolites; Immunity; Methionine; Inflammation; Cell activation; Hepatitis; Gene expression; Antibodies; CD4 antigen; Pollutants; Immunogenicity; Liver; Lymphocytes T; Trichloroethylene; Drinking water; homocysteine DO - http://dx.doi.org/10.1021/tx800409r ER - TY - JOUR T1 - Occupational exposure to nanomedical applications AN - 869595310; 14821096 AB - Applications of nanotechnology in medicine such as cancer treatment drugs, imaging agents, and sensors promise to save people's lives and improve quality of life. Although only a limited number of nano-enabled medical applications are commercially available at this time, many are in the final stages of approval by regulatory agencies overseeing medical applications. Workers' exposure to nano-enabled medical applications in research and development laboratories and manufacturing facilities can already occur. This article reviews the information available on exposure to nano-enabled medical applications in occupational settings such as manufacturing and health care facilities. First, this report reviews monitoring exposure to conventional medical applications. Next, it describes monitoring exposure to nanomaterials. And, finally, it summarizes monitoring exposure to nano-enabled medical applications highlighting their unique aspects. JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Murashov, Vladimir AD - National Institute for Occupational Safety and Health, 395 E Street, S.W. Washington, D.C. 20201, USA, vladimir.murashov@cdc.hhs.gov Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 SP - 203 EP - 213 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 1 IS - 2 SN - 1939-0041, 1939-0041 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - Manufacturing industry KW - Sensors KW - imaging KW - Cancer KW - Health care KW - Reviews KW - Computed tomography KW - quality of life KW - Research programs KW - Occupational exposure KW - nanotechnology KW - Quality of life KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - W 30910:Imaging KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869595310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Occupational+exposure+to+nanomedical+applications&rft.au=Murashov%2C+Vladimir&rft.aulast=Murashov&rft.aufirst=Vladimir&rft.date=2009-03-01&rft.volume=1&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.31 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Computed tomography; imaging; Cancer; Occupational exposure; Quality of life; nanotechnology; Manufacturing industry; Sensors; Health care; Reviews; quality of life; Research programs DO - http://dx.doi.org/10.1002/wnan.31 ER - TY - JOUR T1 - Concentration and Detection of Salmonella in Mung Bean Sprout Spent Irrigation Water by Use of Tangential Flow Filtration Coupled with an Amperometric Flowthrough Enzyme-Linked Immunosorbent Assay AN - 744670665; 12685573 AB - The development of a culture-free method for Salmonella screening of spent irrigation water derived from sprouting mung bean beds is described. The system used tangential flow filtration (TFF) to nonspecifically concentrate cells from large (2- to 10-liter) sample volumes. The retentate (100 ml) from the TFF was then flowed over an anti-Salmonella antibody-modified cellulose acetate membrane. The captured Salmonella was detected by reacting with a secondary anti-Salmonella and goat anti-rabbit biotin labeled antibody, followed by avidin-tagged glucose oxidase. The hydrogen peroxide generated from the enzymic oxidation of glucose was amperometrically detected at an underlying platinum electrode. It was found that 10 liters of Salmonella suspensions of 2 log CFU/ml could be concentrated to 4 log CFU/ml with 60% recovery regardless of the flow rate (112 to 511 ml/min) or transmembrane pressure (0 to 20 lb/in super( 2)) applied. The solids content of spent irrigation water negatively affected the filtration rate of TFF. This was most evident in spent irrigation water collected in the initial 24 h of the sprouting period, where the solids content was high (4,170 mg/liter) compared with samples collected at 96 h (560 mg/liter). Trials were performed using mung bean beds inoculated with different Salmonella levels (1.3 to 3.3 log CFU/g). By using the optimized TFF and flowthrough immunoassay it was possible to detect Salmonella in spent irrigation water at levels of 2.43 log CFU/ml within 4 h. The integrated concentration and detection system will provide a useful tool for sprout producers to perform in-house pathogen screening of spent irrigation water. JF - Journal of Food Protection AU - McEgan, R AU - Fu, T J AU - Warriner, K AD - Department of Food Science, University of Guelph, Guelph, Ontario NlG 2WI, Canada; and 2 US. Food and Drug Administration, National Center for Food Safety and Technology, Summit-Argo, Illinois 60501, USAMS 08-168: Received 5 April 2008/Accepted 3 July 2008* Author for correspondence. Tel: 519 824 4120, Ext 56072; Fax: 519 824 6631; kwarrine[AT]uoguelph.ca. Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 591 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 72 IS - 3 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology KW - Glucose oxidase KW - Enzyme-linked immunosorbent assay KW - Irrigation KW - Glucose KW - Pathogens KW - Beans KW - Antibodies KW - cellulose acetate KW - Filtration KW - Hydrogen peroxide KW - Colony-forming cells KW - Electrodes KW - Oxidation KW - Platinum KW - Pressure KW - Salmonella KW - Biotin KW - J 02420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744670665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Concentration+and+Detection+of+Salmonella+in+Mung+Bean+Sprout+Spent+Irrigation+Water+by+Use+of+Tangential+Flow+Filtration+Coupled+with+an+Amperometric+Flowthrough+Enzyme-Linked+Immunosorbent+Assay&rft.au=McEgan%2C+R%3BFu%2C+T+J%3BWarriner%2C+K&rft.aulast=McEgan&rft.aufirst=R&rft.date=2009-03-01&rft.volume=72&rft.issue=3&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 46 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Glucose oxidase; Enzyme-linked immunosorbent assay; Irrigation; Glucose; Pathogens; Beans; Filtration; cellulose acetate; Antibodies; Hydrogen peroxide; Colony-forming cells; Oxidation; Electrodes; Platinum; Pressure; Biotin; Salmonella ER - TY - JOUR T1 - Exposure of U.S. Children to Residential Dust Lead, 1999-2004: I. Housing and Demographic Factors AN - 743577994; 201004-31-0313491 (CE); 12122194 (EN) AB - BACKGROUND: Lead-contaminated house dust is a major source of lead exposure for children in the United States. In 1999-2004, the National Health and Nutrition Examination Survey (NHANES) collected dust lead (PbD) loading samples from the homes of children 12-60 months of age. OBJECTIVES: In this study we aimed to compare national PbD levels with existing health-based standards and to identify housing and demographic factors associated with floor and windowsill PbD. METHODS: We used NHANES PbD data (n=2,065 from floors and n=1,618 from windowsills) and covariates to construct linear and logistic regression models. RESULTS: The population-weighted geometric mean floor and windowsill PbD were 0.5 microg/ft2 [geometric standard error (GSE)=1.0] and 7.6 microg/ft2 (GSE=1.0), respectively. Only 0.16% of the floors and 4.0% of the sills had PbD at or above current federal standards of 40 and 250 microg/ft2, respectively. Income, race/ethnicity, floor surface/condition, windowsill PbD, year of construction, recent renovation, smoking, and survey year were significant predictors of floor PbD [the proportion of variability in the dependent variable accounted for by the model (R2)=35%]. A similar set of predictors plus the presence of large areas of exterior deteriorated paint in pre-1950 homes and the presence of interior deteriorated paint explained 20% of the variability in sill PbD. A companion article [Dixon et al. Environ Health Perspect 117:468-474 (2009)] describes the relationship between children's blood lead and PbD. CONCLUSION: Most houses with children have PbD levels that comply with federal standards but may put children at risk. Factors associated with PbD in our population-based models are primarily the same as factors identified in smaller at-risk cohorts. PbD on floors and windowsills should be kept as low as possible to protect children. JF - Environmental Health Perspectives AU - Gaitens, Joanna M AU - Dixon, Sherry L AU - Jacobs, David E AU - Nagaraja, Jyothi AU - Strauss, Warren AU - Wilson, Jonathan W AU - Ashley, Peter J PY - 2009 SP - 461 EP - 467 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Standards KW - Mathematical models KW - Children KW - Protective coatings KW - Paints KW - Health KW - Painting KW - Houses KW - Dust KW - Construction KW - Housing KW - Demographics KW - Deterioration KW - Nutrition KW - Risk KW - Regression KW - Race KW - Standard error KW - Dust control KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743577994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+of+U.S.+Children+to+Residential+Dust+Lead%2C+1999-2004%3A+I.+Housing+and+Demographic+Factors&rft.au=Gaitens%2C+Joanna+M%3BDixon%2C+Sherry+L%3BJacobs%2C+David+E%3BNagaraja%2C+Jyothi%3BStrauss%2C+Warren%3BWilson%2C+Jonathan+W%3BAshley%2C+Peter+J&rft.aulast=Gaitens&rft.aufirst=Joanna&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Exposure of U.S. Children to Residential Dust Lead, 1999-2004: II. The Contribution of Lead-Contaminated Dust to Children's Blood Lead Levels AN - 743577177; 201004-31-0313602 (CE); 12122603 (EN) AB - BACKGROUND: The U.S. Centers for Disease Control and Prevention collected health, housing, and environmental data in a single integrated national survey for the first time in the United States in 1999-2004. OBJECTIVES: We aimed to determine how floor dust lead (PbD) loadings and other housing factors influence childhood blood lead (PbB) levels and lead poisoning. METHODS: We analyzed data from the 1999-2004 National Health and Nutrition Examination Survey (NHANES), including 2,155 children 12-60 months of age with PbB and PbD measurements. We used linear and logistic regression models to predict log-transformed PbB and the odds that PbB was or=5 and or=10 microg/dL at a range of floor PbD. RESULTS: The population-weighted geometric mean (GM) PbB was 2.0 microg/dL (geometric standard error=1.0). Age of child, race/ethnicity, serum cotinine concentration, poverty-to-income ratio, country of birth, year of building construction, floor PbD by floor surface and condition, windowsill PbD, presence of deteriorated paint, home-apartment type, smoking in the home, and recent renovation were significant predictors in either the linear model [the proportion of variability in the dependent variable accounted for by the model (R2)=40%] or logistic model for 10 microg/dL (R2=5%). At floor PbD=12 microg/ft2, the models predict that 4.6% of children living in homes constructed before 1978 have PbBor=10 microg/dL, 27% have PbBor=5 microg/dL, and the GM PbB is 3.9 microg/dL. CONCLUSIONS: Lowering the floor PbD standard below the current standard of 40 microg/ft2 would protect more children from elevated PbB. JF - Environmental Health Perspectives AU - Dixon, Sherry L AU - Gaitens, Joanna M AU - Jacobs, David E AU - Strauss, Warren AU - Nagaraja, Jyothi AU - Pivetz, Tim AU - Wilson, W AU - Ashley, Peter J PY - 2009 SP - 468 EP - 474 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Mathematical models KW - Health KW - Protective coatings KW - Standards KW - Dust KW - Paints KW - Painting KW - Construction KW - Housing KW - Logistics KW - Age KW - Blood KW - Nutrition KW - Regression KW - Disease control KW - Race KW - Elevated KW - Lead poisoning KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743577177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+of+U.S.+Children+to+Residential+Dust+Lead%2C+1999-2004%3A+II.+The+Contribution+of+Lead-Contaminated+Dust+to+Children%27s+Blood+Lead+Levels&rft.au=Dixon%2C+Sherry+L%3BGaitens%2C+Joanna+M%3BJacobs%2C+David+E%3BStrauss%2C+Warren%3BNagaraja%2C+Jyothi%3BPivetz%2C+Tim%3BWilson%2C+W%3BAshley%2C+Peter+J&rft.aulast=Dixon&rft.aufirst=Sherry&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=468&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Exposure to Mouse Allergen in U.S. Homes Associated with Asthma Symptoms AN - 743575657; 201004-31-0313612 (CE); 12122613 (EN) AB - BACKGROUND: Most studies investigating the role of residential mouse allergen exposures in asthma have focused on inner-city populations. OBJECTIVE: We examined whether elevated mouse allergen levels were associated with occupants' asthma status in a nationally representative sample of U.S. households. METHODS: Data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed 831 housing units inhabited by 2,456 individuals in 75 different locations throughout the United States. The survey obtained information on demographics, household characteristics, and occupants' health status by questionnaire and environmental observations. We used a polyclonal immunoassay to assess concentrations of mouse urinary protein (MUP) in vacuumed dust collected from various indoor sites. RESULTS: Of the surveyed homes, 82% had detectable levels of MUP, and in 35% of the homes, MUP concentrations exceeded 1.6 microg/g, a level that has been associated with increased mouse allergen sensitization rates. Current asthma, defined as having doctor-diagnosed asthma and asthma symptoms in the preceding 12 months, was positively associated with increased MUP levels. The observed association was modified by atopic status; in allergic individuals, elevated MUP levels (1.6 microg/g) increased the odds of having asthma symptoms [adjusted OR=1.93; 95% confidence interval (CI), 1.14-3.27], but we found no association in those who did not report allergies (adjusted OR=0.69; 95% CI, 0.33-1.44). CONCLUSIONS: In allergic asthma, residential mouse allergen exposure is an important risk factor for asthma morbidity. JF - Environmental Health Perspectives AU - Salo, Paeivi M AU - Jaramillo, Renee AU - Cohn, Richard D AU - London, Stephanie J AU - Zeldin, Darryl C PY - 2009 SP - 387 EP - 391 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Asthma KW - Health KW - Housing KW - Elevated KW - Households KW - Adjustment KW - Residential KW - Cross sections KW - Confidence intervals KW - Immunoassay KW - Copyrights KW - Demographics KW - Indoor KW - Proteins KW - Dust control KW - Risk KW - Populations KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743575657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Exposure+to+Mouse+Allergen+in+U.S.+Homes+Associated+with+Asthma+Symptoms&rft.au=Salo%2C+Paeivi+M%3BJaramillo%2C+Renee%3BCohn%2C+Richard+D%3BLondon%2C+Stephanie+J%3BZeldin%2C+Darryl+C&rft.aulast=Salo&rft.aufirst=Paeivi&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol A AN - 743562493; 201004-31-0313623 (CE); 12122624 (EN) AB - BACKGROUND: In their safety evaluations of bisphenol A (BPA), the U.S. Food and Drug Administration (FDA) and a counterpart in Europe, the European Food Safety Authority (EFSA), have given special prominence to two industry-funded studies that adhered to standards defined by Good Laboratory Practices (GLP). These same agencies have given much less weight in risk assessments to a large number of independently replicated non-GLP studies conducted with government funding by the leading experts in various fields of science from around the world. OBJECTIVES: We reviewed differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories to identify hazards and molecular mechanisms mediating adverse effects. We examined the methods and results in the GLP studies that were pivotal in the draft decision of the U.S. FDA declaring BPA safe in relation to findings from studies that were competitive for U.S. National Institutes of Health (NIH) funding, peer-reviewed for publication in leading journals, subject to independent replication, but rejected by the U.S. FDA for regulatory purposes. DISCUSSION: Although the U.S. FDA and EFSA have deemed two industry-funded GLP studies of BPA to be superior to hundreds of studies funded by the U.S. NIH and NIH counterparts in other countries, the GLP studies on which the agencies based their decisions have serious conceptual and methodologic flaws. In addition, the U.S. FDA and EFSA have mistakenly assumed that GLP yields valid and reliable scientific findings (i.e., "good science"). Their rationale for favoring GLP studies over hundreds of publically funded studies ignores the central factor in determining the reliability and validity of scientific findings, namely, independent replication, and use of the most appropriate and sensitive state-of-the-art assays, neither of which is an expectation of industry-funded GLP research. CONCLUSIONS: Public health decisions should be based on studies using appropriate protocols with appropriate controls and the most sensitive assays, not GLP. Relevant NIH-funded research using state-of-the-art techniques should play a prominent role in safety evaluations of chemicals. JF - Environmental Health Perspectives AU - Myers, John Peterson AU - vom Saal, Frederick S AU - Akingbemi, Benson T AU - Arizono, Koji AU - Beicher, Scott AU - Colborn, Theo AU - Chahoud, Ibrahim AU - Crain, D Andrew AU - Farabollini, Francesca AU - Guillette, Louis J AU - Hassold, Terry AU - Ho, Shuk-mei AU - Hunt, Patricia A AU - Iguchi, Taisen AU - Jobling, Susan AU - Kanno, Jun AU - Laufer, Hans AU - Marcus, Michele AU - McLachian, John A PY - 2009 SP - 309 EP - 315 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Standards KW - Health KW - Safety KW - Bisphenol A KW - State of the art KW - Funding KW - Replication KW - Foods KW - Public health KW - Assaying KW - Governments KW - Safes KW - Drugs KW - Criteria KW - Koji KW - Hazards KW - Control equipment KW - Copyrights KW - Prominences KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743562493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Why+Public+Health+Agencies+Cannot+Depend+on+Good+Laboratory+Practices+as+a+Criterion+for+Selecting+Data%3A+The+Case+of+Bisphenol+A&rft.au=Myers%2C+John+Peterson%3Bvom+Saal%2C+Frederick+S%3BAkingbemi%2C+Benson+T%3BArizono%2C+Koji%3BBeicher%2C+Scott%3BColborn%2C+Theo%3BChahoud%2C+Ibrahim%3BCrain%2C+D+Andrew%3BFarabollini%2C+Francesca%3BGuillette%2C+Louis+J%3BHassold%2C+Terry%3BHo%2C+Shuk-mei%3BHunt%2C+Patricia+A%3BIguchi%2C+Taisen%3BJobling%2C+Susan%3BKanno%2C+Jun%3BLaufer%2C+Hans%3BMarcus%2C+Michele%3BMcLachian%2C+John+A&rft.aulast=Myers&rft.aufirst=John&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Variability in Biomarkers of Arsenic Exposure and Metabolism in Adults over Time AN - 743551097; 201004-31-0313603 (CE); 12122604 (EN) AB - BACKGROUND: Urinary arsenic metabolites (UAs) are used as biomarkers of exposure and metabolism. OBJECTIVES: To characterize inter- and intraindividual variability in UAs in healthy individuals. METHODS: In a longitudinal study conducted in Bangladesh, we collected water and spot urine samples from 196 participants every 3 months for 2 years. Water arsenic (As) was measured by inductively coupled plasma-mass spectrometry and urinary As [arsenite, arsenate, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA)] were detected using high-performance liquid chromatography-hydride-generated atomic absorption spectrometry. We used linear mixed-effects models to compute variance components and evaluate the association between UAs and selected factors. RESULTS: The concentrations of UAs were fairly reproducible within individuals, with intraclass correlation coefficients (ICCs) of 0.41, 0.35, 0.47, and 0.49 for inorganic As (InAs), MMA, DMA, and total urinary As (TUA). However, when expressed as a ratio, the percent InAs (%InAs), %MMA, and %DMA were poorly reproducible within individuals, with ICCs of 0.16, 0.16, and 0.17, respectively. Arsenic metabolism was significantly associated with sex, exposure, age, smoking, chewing betel nut, urinary creatinine, and season. Specificity and sensitivity analyses showed that a single urine sample adequately classified a participant's urinary As profile as high or low, but TUA had only moderate specificity for correctly classifying drinking water exposures. CONCLUSIONS: Epidemiologic studies should use both urinary As concentrations and the relative proportion of UAs to minimize measurement error and to facilitate interpretation of factors that influence As metabolism. JF - Environmental Health Perspectives AU - Kile, Molly L AU - Hoffman, Elaine AU - Hsueh, Yu-Mei AU - Afroz, Sakila AU - Quamruzzaman, Quazi AU - Rahman, Mahmuder AU - Mahiuddin, Golam AU - Ryan, Louise AU - Christiani, David C PY - 2009 SP - 455 EP - 460 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Metabolism KW - Arsenic KW - Polymethyl methacrylates KW - Indium arsenides KW - Health KW - Urine KW - Sensitivity analysis KW - Drinking water KW - Adults KW - Epidemiology KW - Metabolites KW - Liquids KW - Variance KW - Seasons KW - Error analysis KW - Classification KW - Arsenates KW - Spectroscopy KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743551097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Variability+in+Biomarkers+of+Arsenic+Exposure+and+Metabolism+in+Adults+over+Time&rft.au=Kile%2C+Molly+L%3BHoffman%2C+Elaine%3BHsueh%2C+Yu-Mei%3BAfroz%2C+Sakila%3BQuamruzzaman%2C+Quazi%3BRahman%2C+Mahmuder%3BMahiuddin%2C+Golam%3BRyan%2C+Louise%3BChristiani%2C+David+C&rft.aulast=Kile&rft.aufirst=Molly&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Synergistic Toxicity of Pesticide Mixtures: Implications for Risk Assessment and the Conservation of Endangered Pacific Salmon AN - 743522457; 201004-31-0313615 (CE); 12122616 (EN) AB - BACKGROUND: Mixtures of organophosphate and carbamate pesticides are commonly detected in freshwater habitats that support threatened and endangered species of Pacific salmon (Oncorhynchus sp.). These pesticides inhibit the activity of acetylcholinesterase (AChE) and thus have potential to interfere with behaviors that may be essential for salmon survival. Although the effects of individual anticholin-esterase insecticides on aquatic species have been studied for decades, the neurotoxicity of mixtures is still poorly understood. OBJECTIVES: We assessed whether chemicals in a mixture act in isolation (resulting in additive AChE inhibition) or whether components interact to produce either antagonistic or synergistic toxicity. METHODS: We measured brain AChE inhibition in juvenile coho salmon (Oncorhynchus kisutch) exposed to sublethal concentrations of the organophosphates diazinon, malathion, and chlorpyrifos, as well as the carbamates carbaryl and carbofuran. Concentrations of individual chemicals were normalized to their respective median effective concentrations (EC50) and collectively fit to a nonlinear regression. We used this curve to determine whether toxicologic responses to binary mixtures were additive, antagonistic, or synergistic. RESULTS: We observed addition and synergism, with a greater degree of synergism at higher exposure concentrations. Several combinations of organophosphates were lethal at concentrations that were sublethal in single-chemical trials. CONCLUSION: Single-chemical risk assessments are likely to underestimate the impacts of these insecticides on salmon in river systems where mixtures occur. Moreover, mixtures of pesticides that have been commonly reported in salmon habitats may pose a more important challenge for species recovery than previously anticipated. JF - Environmental Health Perspectives AU - Laetz, Cathy A AU - Baldwin, David H AU - Collier, Tracy K AU - Hebert, Vincent AU - Stark, John D AU - Scholz, Nathaniel L PY - 2009 SP - 348 EP - 353 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Salmon KW - Pesticides KW - Organophosphates KW - Toxicity KW - Insecticides KW - Health KW - Habitats KW - Inhibition KW - Additives KW - Risk assessment KW - Coal mines KW - Conservation KW - Chlorpyrifos KW - Regression KW - Endangered species KW - Nonlinearity KW - Binary mixtures KW - Rivers KW - Copyrights KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743522457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Synergistic+Toxicity+of+Pesticide+Mixtures%3A+Implications+for+Risk+Assessment+and+the+Conservation+of+Endangered+Pacific+Salmon&rft.au=Laetz%2C+Cathy+A%3BBaldwin%2C+David+H%3BCollier%2C+Tracy+K%3BHebert%2C+Vincent%3BStark%2C+John+D%3BScholz%2C+Nathaniel+L&rft.aulast=Laetz&rft.aufirst=Cathy&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Proteasome is a Molecular Target of Environmental Toxic Organotins AN - 743514551; 201004-31-0313609 (CE); 12122610 (EN) AB - BACKGROUND: Because of the vital importance of the proteasome pathway, chemicals affecting proteasome activity could disrupt essential cellular processes. Although the toxicity of organotins to both invertebrates and vertebrates is well known, the essential cellular target of organotins has not been well identified. We hypothesize that the proteasome is a molecular target of environmental toxic organotins. OBJECTIVES: Our goal was to test the above hypothesis by investigating whether organotins could inhibit the activity of purified and cellular proteasomes and, if so, the involved molecular mechanisms and downstream events. RESULTS: We found that some toxic organotins [e.g., triphenyltin (TPT)] can potently and preferentially inhibit the chymotrypsin-like activity of purified 20S proteasomes and human breast cancer cellular 26S proteasomes. Direct binding of tin atoms to cellular proteasomes is responsible for the observed irreversible inhibition. Inhibition of cellular proteasomes by TPT in several human cell lines results in the accumulation of ubiquitinated proteins and natural proteasome target proteins, accompanied by induction of cell death. CONCLUSIONS: The proteasome is one of the molecular targets of environmental toxic organotins in human cells, and proteasome inhibition by organotins contributes to their cellular toxicity. JF - Environmental Health Perspectives AU - Shi, Guoqing AU - Chen, Di AU - Zhai, Guangshu AU - Chen, Marina S AU - Cui, Qiuzhi Cindy AU - Zhou, Qunfang AU - He, Bin AU - Dou, Q Ping AU - Jiang, Guibin PY - 2009 SP - 379 EP - 386 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Cellular KW - Toxic KW - Toxicology KW - Inhibition KW - Human KW - Toxicity KW - Health KW - Proteins KW - Breast KW - Binding KW - Marinas KW - Invertebrates KW - Cancer KW - Vertebrates KW - Copyrights KW - Cell death KW - Pathways KW - Tin KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743514551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Proteasome+is+a+Molecular+Target+of+Environmental+Toxic+Organotins&rft.au=Shi%2C+Guoqing%3BChen%2C+Di%3BZhai%2C+Guangshu%3BChen%2C+Marina+S%3BCui%2C+Qiuzhi+Cindy%3BZhou%2C+Qunfang%3BHe%2C+Bin%3BDou%2C+Q+Ping%3BJiang%2C+Guibin&rft.aulast=Shi&rft.aufirst=Guoqing&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Effects of Fine Particle Components on Respiratory Hospital Admissions in Children AN - 743511117; 201004-31-0313601 (CE); 12122602 (EN) AB - BACKGROUND: Epidemiologic studies have demonstrated an association between acute exposure to ambient fine particles and both mortality and morbidity. Less is known about the relative impacts of the specific chemical constituents of particulate matter2.5 microm in aerodynamic diameter (PM2.5) on hospital admissions. OBJECTIVE: This study was designed to estimate the risks of exposure to PM2.5 and several species on hospital admissions for respiratory diseases among children. DATA AND METHODS: We obtained data on daily counts of hospitalizations for children19 and 5 years of age for total respiratory diseases and several subcategories including pneumonia, acute bronchitis, and asthma for six California counties from 2000 through 2003, as well as ambient concentrations of PM2.5 and its constituents, including elemental carbon (EC), organic carbon (OC), and nitrates (NO3). We used Poisson regression to estimate risks while controlling for important covariates. RESULTS: We observed associations between several components of PM2.5 and hospitalization for all of the respiratory outcomes examined. For example, for total respiratory admissions for children19 years of age, the interquartile range for a 3-day lag of PM2.5, EC, OC, NO3, and sulfates was associated with an excess risk of 4.1% [95% confidence interval (CI), 1.8-6.4], 5.4% (95% CI, 0.8-10.3), 3.4% (95% CI, 1.1-5.7), 3.3% (95% CI, 1.1-5.5), and 3.0% (95% CI, 0.4-5.7), respectively. We also observed associations for several metals. Additional associations with several of the species, including potassium, were observed in the cool season. CONCLUSION: Components of PM2.5 were associated with hospitalization for several childhood respiratory diseases including pneumonia, bronchitis, and asthma. Because exposure to components (e.g., EC, OC, NO3, and K) and their related sources, including diesel and gasoline exhaust, wood smoke, and other combustion sources, are ubiquitous in the urban environment, it likely represents an identifiable and preventable risk factor for hospitalization for children. JF - Environmental Health Perspectives AU - Ostro, Bart AU - Roth, Lindsey AU - Malig, Brian AU - Marty, Melanie PY - 2009 SP - 475 EP - 480 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Children KW - Hospitals KW - Respiratory diseases KW - Carbon KW - Asthma KW - Estimates KW - Constituents KW - Health KW - Pneumonia KW - Age KW - Combustion KW - Wood KW - Sulfates KW - Smoke KW - Regression KW - Urban environments KW - Diesel KW - Epidemiology KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743511117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Effects+of+Fine+Particle+Components+on+Respiratory+Hospital+Admissions+in+Children&rft.au=Ostro%2C+Bart%3BRoth%2C+Lindsey%3BMalig%2C+Brian%3BMarty%2C+Melanie&rft.aulast=Ostro&rft.aufirst=Bart&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The Controversy about a Possible Relationship between Mobile Phone Use and Cancer AN - 743498556; 201004-31-0313622 (CE); 12122623 (EN) AB - OBJECTIVE: During the last decade, mobile phone use increased to almost 100% prevalence in many countries of the world. Evidence for potential health hazards accumulated in parallel by epidemiologic investigations has raised controversies about the appropriate interpretation and the degree of bias and confounding responsible for reduced or increased risk estimates. DATA SOURCES: Overall, I identified 33 epidemiologic studies in the peer-reviewed literature, most of which (25) were about brain tumors. Two groups have collected data for or=10 years of mobile phone use: Hardell and colleagues from Sweden and the Interphone group, an international consortium from 13 countries coordinated by the International Agency for Research on Cancer. DATA SYNTHESIS: Combined odds ratios (95% confidence intervals) from these studies for glioma, acoustic neuroma, and meningioma were 1.5 (1.2-1.8); 1.3 (0.95-1.9); and 1.1 (0.8-1.4), respectively. CONCLUSIONS: Methodologic considerations revealed that three important conditions for epidemiologic studies to detect an increased risk are not met: a ) no evidence-based exposure metric is available; b) the observed duration of mobile phone use is generally still too low; c) no evidence-based selection of end points among the grossly different types of neoplasias is possible because of lack of etiologic hypotheses. Concerning risk estimates, selection bias, misclassification bias, and effects of the disease on mobile phone use could have reduced estimates, and recall bias may have led to spuriously increased risks. The overall evidence speaks in favor of an increased risk, but its magnitude cannot be assessed at present because of insufficient information on long-term use. JF - Environmental Health Perspectives AU - Kundi, Michael PY - 2009 SP - 316 EP - 324 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Telephones KW - Bias KW - Epidemiology KW - Estimates KW - Health KW - Cancer KW - Recall KW - Austenitic stainless steels KW - Data sources KW - Tumors KW - Acoustics KW - Confidence intervals KW - Interphones KW - Health hazards KW - Synthesis KW - Copyrights KW - Brain KW - Etiology KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743498556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Controversy+about+a+Possible+Relationship+between+Mobile+Phone+Use+and+Cancer&rft.au=Kundi%2C+Michael&rft.aulast=Kundi&rft.aufirst=Michael&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Short-Term Mortality Rates during a Decade of Improved Air Quality in Erfurt, Germany AN - 743446949; 201004-31-0313604 (CE); 12122605 (EN) AB - BACKGROUND: Numerous studies have shown associations between ambient air pollution and daily mortality. OBJECTIVES: Our goal was to investigate the association of ambient air pollution and daily mortality in Erfurt, Germany, over a 10.5-year period after the German unification, when air quality improved. METHODS: We obtained daily mortality counts and data on mass concentrations of particulate matter (PM)10 microm in aerodynamic diameter (PM10), gaseous pollutants, and meteorology in Erfurt between October 1991 and March 2002. We obtained ultrafine particle number concentrations (UFP) and mass concentrations of PM2.5 microm in aerodynamic diameter (PM2.5) from September 1995 to March 2002. We analyzed the data using semiparametric Poisson regression models adjusting for trend, seasonality, influenza epidemics, day of the week, and meteorology. We evaluated cumulative associations between air pollution and mortality using polynomial distributed lag (PDL) models and multiday moving averages of air pollutants. We evaluated changes in the associations over time in time-varying coefficient models. RESULTS: Air pollution concentrations decreased over the study period. Cumulative exposure to UFP was associated with increased mortality. An interquartile range (IQR) increase in the 15-day cumulative mean UFP of 7,649 cm(-3) was associated with a relative risk (RR) of 1.060 [95% confidence interval (CI), 1.008-1.114] for PDL models and an RR/IQR of 1.055 (95% CI, 1.011-1.101) for moving averages. RRs decreased from the mid-1990s to the late 1990s. CONCLUSION: Results indicate an elevated mortality risk from short-term exposure to UFP. They further suggest that RRs for short-term associations of air pollution decreased as pollution control measures were implemented in Eastern Germany. JF - Environmental Health Perspectives AU - Breitner, Susanne AU - Stoekel, Matthias AU - Cyrys, Josef AU - Pitz, Mike AU - Woelke, Gabriele AU - Kreyling, Wolfgang AU - Kuechenhoff, Helmut AU - Heinrich, Joachim AU - Wichmann, H-Erich AU - Peters, Annette PY - 2009 SP - 448 EP - 454 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mortality KW - Air pollution KW - Risk KW - Meteorology KW - Health KW - Air quality KW - Pollutants KW - Aerodynamics KW - Pollution control KW - Regression KW - Coefficients KW - Mathematical models KW - Confidence intervals KW - Elevated KW - Ultrafines KW - Copyrights KW - Counting KW - Influenza KW - Epidemics KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743446949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Short-Term+Mortality+Rates+during+a+Decade+of+Improved+Air+Quality+in+Erfurt%2C+Germany&rft.au=Breitner%2C+Susanne%3BStoekel%2C+Matthias%3BCyrys%2C+Josef%3BPitz%2C+Mike%3BWoelke%2C+Gabriele%3BKreyling%2C+Wolfgang%3BKuechenhoff%2C+Helmut%3BHeinrich%2C+Joachim%3BWichmann%2C+H-Erich%3BPeters%2C+Annette&rft.aulast=Breitner&rft.aufirst=Susanne&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Proximity to Traffic: Inflammation, and Immune Function among Women in the Seattle, Washington, Area AN - 743394717; 201004-31-0313611 (CE); 12122612 (EN) AB - BACKGROUND: Traffic-related air pollution has been associated with adverse health outcomes, and the immune system may be a biologic mediator of health effects. OBJECTIVES: We analyzed associations between living near major roads and immune status as measured by five immune assays. We hypothesized that living near a freeway, arterial, or truck route would be associated with increased inflammation and decreased immune function. METHODS: We used a geographic information system (GIS) to determine residential proximity to major roads among 115 postmenopausal, overweight women in the greater Seattle, Washington (USA), area whose immunity was assessed at the baseline visit of an exercise intervention trial. We evaluated three inflammatory markers (C-reactive protein, serum amyloid A, and interleukin-6) and two functional assays of cellular immunity [natural killer (NK) cell cytotoxicity and T-lymphocyte proliferation]. RESULTS: Women living within 150 m of arterial roads had 21% lower NK cytotoxicity compared with women who lived farther from an arterial [mean cytotoxicity, 19.5%; 95% confidence interval (CI), 15.6-23.5%; vs. mean cytotoxicity, 24.8%; 95% CI, 22.0-27.5%], after adjustment for both individual-level and census tract-level demographic characteristics. This association was limited to women who reported exercising near traffic. Fewer women lived near freeways and truck routes. Markers of inflammation and lymphocyte proliferation did not consistently differ according to proximity to major roads. CONCLUSIONS: If the observed association between residential proximity to traffic and decreased NK cytotoxicity is confirmed in other populations, our results may have implications for local land use policy. JF - Environmental Health Perspectives AU - Williams, Lori A AU - Ulrich, Cornelia M AU - Larson, Timothy AU - Wener, Mark H AU - Wood, Brent AU - Campbell, Peter T AU - Potter, John D AU - McTiernan, Anne AU - De Roos, Annecleire J PY - 2009 SP - 373 EP - 378 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Roads KW - Health KW - Proximity KW - Traffic flow KW - Traffic engineering KW - Biological effects KW - Geographic information systems KW - Markers KW - Freeways KW - Satellite navigation systems KW - Trucks KW - Immunity KW - Assaying KW - Residential KW - Wood KW - Air pollution KW - Policies KW - Cellular KW - Census KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743394717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Proximity+to+Traffic%3A+Inflammation%2C+and+Immune+Function+among+Women+in+the+Seattle%2C+Washington%2C+Area&rft.au=Williams%2C+Lori+A%3BUlrich%2C+Cornelia+M%3BLarson%2C+Timothy%3BWener%2C+Mark+H%3BWood%2C+Brent%3BCampbell%2C+Peter+T%3BPotter%2C+John+D%3BMcTiernan%2C+Anne%3BDe+Roos%2C+Annecleire+J&rft.aulast=Williams&rft.aufirst=Lori&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database AN - 743387444; 201004-31-0313607 (CE); 12122608 (EN) AB - BACKGROUND: Thirty years of pesticide registration toxicity data have been historically stored as hardcopy and scanned documents by the U.S. Environmental Protection Agency (EPA). A significant portion of these data have now been processed into standardized and structured toxicity data within the EPA's Toxicity Reference Database (ToxRefDB), including chronic, cancer, developmental, and reproductive studies from laboratory animals. These data are now accessible and mineable within ToxRefDB and are serving as a primary source of validation for U.S. EPA's ToxCast research program in predictive toxicology. OBJECTIVES: We profiled in vivo toxicities across 310 chemicals as a model application of ToxRefDB, meeting the need for detailed anchoring end points for development of ToxCast predictive signatures. METHODS: Using query and structured data-mining approaches, we generated toxicity profiles from ToxRefDB based on long-term rodent bioassays. These chronic/cancer data were analyzed for suitability as anchoring end points based on incidence, target organ, severity, potency, and significance. RESULTS: Under conditions of the bioassays, we observed pathologies for 273 of 310 chemicals, with greater preponderance (90%) occurring in the liver, kidney, thyroid, lung, testis, and spleen. We observed proliferative lesions for 225 chemicals, and 167 chemicals caused progression to cancer-related pathologies. CONCLUSIONS: Based on incidence, severity, and potency, we selected 26 primarily tissue-specific pathology end points to uniformly classify the 310 chemicals. The resulting toxicity profile classifications demonstrate the utility of structuring legacy toxicity information and facilitating the computation of these data within ToxRefDB for ToxCast and other applications. JF - Environmental Health Perspectives AU - Martin, Matthew T AU - Judson, Richard S AU - Reif, David M AU - Kavlock, Robert J AU - Dix, David J PY - 2009 SP - 392 EP - 399 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Biocompatibility KW - Toxicity KW - Databases KW - Pathology KW - Bioassay KW - Anchoring KW - Health KW - Mathematical models KW - Cancer KW - Incidence KW - Signatures KW - Spleen KW - Kidneys KW - Surgical implants KW - Laboratory animals KW - Biomedical materials KW - Profiling KW - Meetings KW - Classification KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743387444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Profiling+Chemicals+Based+on+Chronic+Toxicity+Results+from+the+U.S.+EPA+ToxRef+Database&rft.au=Martin%2C+Matthew+T%3BJudson%2C+Richard+S%3BReif%2C+David+M%3BKavlock%2C+Robert+J%3BDix%2C+David+J&rft.aulast=Martin&rft.aufirst=Matthew&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Apparent Half-Lives of Dioxins, Furans, and Polychlorinated Biphenyls as a Function of Age, Body Fat, Smoking Status, and Breast-Feeding AN - 743379484; 201004-31-0313613 (CE); 12122614 (EN) AB - OBJECTIVE: In this study we reviewed the half-life data in the literature for the 29 dioxin, furan, and polychlorinated biphenyl congeners named in the World Health Organization toxic equivalency factor scheme, with the aim of providing a reference value for the half-life of each congener in the human body and a method of half-life estimation that accounts for an individual's personal characteristics. DATA SOURCES AND EXTRACTION: We compared data from 30 studies containing congener-specific elimination rates. Half-life data were extracted and compiled into a summary table. We then created a subset of these data based on defined exclusionary criteria. DATA SYNTHESIS: We defined values for each congener that approximate the half-life in an infant and in an adult. A linear interpolation of these values was used to examine the relationship between half-life and age, percent body fat, and absolute body fat. We developed predictive equations based on these relationships and adjustments for individual characteristics. CONCLUSIONS: The half-life of dioxins in the body can be predicted using a linear relationship with age adjusted for body fat, smoking, and breast-feeding. Data suggest an alternative method based on a linear relationship between half-life and total body fat, but this approach requires further testing and validation with individual measurements. JF - Environmental Health Perspectives AU - Milbrath, Meghan O'Grady AU - Wenger, Yvan AU - Chang, Chiung-Wen AU - Emond, Claude AU - Garabrant, David AU - Gillespie, Brenda W AU - Jolliet, Olivier PY - 2009 SP - 417 EP - 425 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Congeners KW - Age KW - Dioxins KW - Mathematical analysis KW - Polychlorinated biphenyls KW - Furans KW - Smoking KW - Adjustment KW - Infants KW - Human body KW - Adults KW - Extraction KW - Data sources KW - Criteria KW - Toxic KW - Organizations KW - Summaries KW - Synthesis KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743379484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Apparent+Half-Lives+of+Dioxins%2C+Furans%2C+and+Polychlorinated+Biphenyls+as+a+Function+of+Age%2C+Body+Fat%2C+Smoking+Status%2C+and+Breast-Feeding&rft.au=Milbrath%2C+Meghan+O%27Grady%3BWenger%2C+Yvan%3BChang%2C+Chiung-Wen%3BEmond%2C+Claude%3BGarabrant%2C+David%3BGillespie%2C+Brenda+W%3BJolliet%2C+Olivier&rft.aulast=Milbrath&rft.aufirst=Meghan&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - A Physiologically Based Pharmacokinetic Model for the Assessment of Infant Exposure to Persistent Organic Pollutants in Epidemiologic Studies AN - 743371703; 201004-31-0313600 (CE); 12122601 (EN) AB - BACKGROUND: It has been suggested that pre- and postnatal exposure to persistent organic pollutants (POPs) can promote several adverse effects in children, such as altered neurodevelopment. Epidemiologic studies to date have relied on the analysis of biological samples drawn pre- or post-natally for exposure assessment, an approach that might not capture some key events in the toxicokinetics of POPs. OBJECTIVES: We aimed to build a generic physiologically based pharmacokinetic (PBPK) modeling framework for neutral POPs to assess infant toxicokinetic profiles and to validate the model using data on POP levels measured in mothers and infants from a Northern Quebec Inuit population. METHODS: The PBPK model developed herein was based upon a previously published model to which an infant submodel was added. Using the model and maternal blood levels at the time of delivery, exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT), hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), 2,2',3,4,4',5'-hexachlorobiphenyl (PCB-138), 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153), and 2,2',3,4,4',5,5'-heptachlorobiphenyl (PCB-180) in mothers was estimated to subsequently simulate infant blood, breast milk, and cord blood POP concentration. Simulations were then compared with corresponding measured levels through Spearman correlation analyses. RESULTS: Predictions were highly correlated with measured concentrations for PCB-153, PCB-180, PCB-138, HCB, and p,p'-DDE (r = 0.83-0.96). Weaker correlations were observed for p,p'-DDT and beta-HCH for which levels were near the limits of detection. CONCLUSION: This is the first study to validate a PBPK model of POPs in infants on an individual basis. This approach will reduce sampling efforts and enable the use of individualized POP toxicokinetic profiles in the epidemiologic studies of POP adverse effects on child development. JF - Environmental Health Perspectives AU - Verner, Marc-Andre AU - Ayotte, Pierre AU - Muckle, Gina AU - Charbonneau, Michel AU - Haddad, Sami PY - 2009 SP - 481 EP - 487 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Infants KW - Epidemiology KW - Blood KW - Assessments KW - Computer simulation KW - Health KW - Correlation analysis KW - Construction KW - Pollutants KW - Milk KW - Sampling KW - Breast KW - Children KW - Biological KW - Correlation KW - Rope KW - Copyrights KW - Hexachlorobenzene KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743371703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Physiologically+Based+Pharmacokinetic+Model+for+the+Assessment+of+Infant+Exposure+to+Persistent+Organic+Pollutants+in+Epidemiologic+Studies&rft.au=Verner%2C+Marc-Andre%3BAyotte%2C+Pierre%3BMuckle%2C+Gina%3BCharbonneau%2C+Michel%3BHaddad%2C+Sami&rft.aulast=Verner&rft.aufirst=Marc-Andre&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Public Health Strategies for Western Bangladesh That Address Arsenic, Manganese, Uranium, and Other Toxic Elements in Drinking Water AN - 743366239; 201004-31-0313608 (CE); 12122609 (EN) AB - BACKGROUND: More than 60,000,000 Bangladeshis are drinking water with unsafe concentrations of one or more elements. OBJECTIVES: Our aims in this study were to evaluate and improve the drinking water testing and treatment plans for western Bangladesh. METHODS: We sampled groundwater from four neighborhoods in western Bangladesh to determine the distributions of arsenic, boron, barium, chromium, iron, manganese, molybdenum, nickel, lead, antimony, selenium, uranium, and zinc, and to determine pH. RESULTS: The percentages of tube wells that had concentrations exceeding World Health Organization (WHO) health-based drinking water guidelines were 78% for Mn, 48% for U, 33% for As, 1% for Pb, 1% for Ni, and 1% for Cr. Individual tube wells often had unsafe concentrations of both Mn and As or both Mn and U. They seldom had unsafe concentrations of both As and U. CONCLUSIONS: These results suggest that the ongoing program of identifying safe drinking water supplies by testing every tube well for As only will not ensure safe concentrations of Mn, U, Pb, Ni, Cr, and possibly other elements. To maximize efficiency, drinking water testing in Bangladesh should be completed in three steps: 1) all tube wells must be sampled and tested for As; 2) if a sample meets the WHO guideline for As, then it should be retested for Mn and U; 3) if a sample meets the WHO guidelines for As, Mn, and U, then it should be retested for B, Ba, Cr, Mo, Ni, and Pb. All safe tube wells should be considered for use as public drinking water supplies. JF - Environmental Health Perspectives AU - Frisbie, Seth H AU - Mitchell, Erika J AU - Mastera, Lawrence J AU - Maynard, Donald M AU - Yusuf, Ahmad Zaki AU - Siddiq, Mohammad Yusuf AU - Ortega, Richard AU - Dunn, Richard K AU - Westerman, David S AU - Bacquart, Thomas AU - Sarkar, Bibudhendra PY - 2009 SP - 410 EP - 416 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Manganese KW - Uranium KW - Drinking water KW - Tubes KW - Chromium KW - Nickel KW - Wells KW - Safes KW - Guidelines KW - Lead (metal) KW - Health KW - Arsenic KW - Zinc KW - Molybdenum KW - Toxic KW - Iron KW - Antimony KW - Selenium KW - Strategy KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743366239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Public+Health+Strategies+for+Western+Bangladesh+That+Address+Arsenic%2C+Manganese%2C+Uranium%2C+and+Other+Toxic+Elements+in+Drinking+Water&rft.au=Frisbie%2C+Seth+H%3BMitchell%2C+Erika+J%3BMastera%2C+Lawrence+J%3BMaynard%2C+Donald+M%3BYusuf%2C+Ahmad+Zaki%3BSiddiq%2C+Mohammad+Yusuf%3BOrtega%2C+Richard%3BDunn%2C+Richard+K%3BWesterman%2C+David+S%3BBacquart%2C+Thomas%3BSarkar%2C+Bibudhendra&rft.aulast=Frisbie&rft.aufirst=Seth&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Neighborhood Food Environment and Walkability Predict Obesity in New York City AN - 743325014; 201004-31-0313605 (CE); 12122606 (EN) AB - BACKGROUND: Differences in the neighborhood food environment may contribute to disparities in obesity. OBJECTIVES: The purpose of this study was to examine the association of neighborhood food environments with body mass index (BMI) and obesity after control for neighborhood walkability. METHODS: This study employed a cross-sectional, multilevel analysis of BMI and obesity among 13,102 adult residents of New York City. We constructed measures of the food environment and walkability for the neighborhood, defined as a half-mile buffer around the study subject's home address. RESULTS: Density of BMI-healthy food outlets (supermarkets, fruit and vegetable markets, and natural food stores) was inversely associated with BMI. Mean adjusted BMI was similar in the first two quintiles of healthy food density (0 and 1.13 stores/km2, respectively), but declined across the three higher quintiles and was 0.80 units lower [95% confidence interval (CI), 0.27-1.32] in the fifth quintile (10.98 stores/km2) than in the first. The prevalence ratio for obesity comparing the fifth quintile of healthy food density with the lowest two quintiles combined was 0.87 (95% CI, 0.78-0.97). These associations remained after control for two neighborhood walkability measures, population density and land-use mix. The prevalence ratio for obesity for the fourth versus first quartile of population density was 0.84 (95% CI, 0.73-0.96) and for land-use mix was 0.91 (95% CI, 0.86-0.97). Increasing density of food outlets categorized as BMI-unhealthy was not significantly associated with BMI or obesity. CONCLUSIONS: Access to BMI-healthy food stores is associated with lower BMI and lower prevalence of obesity. JF - Environmental Health Perspectives AU - Rundle, Andrew AU - Neckerman, Kathryn M AU - Freeman, Lance AU - Lovasi, Gina S AU - Purciel, Marnie AU - Quinn, James AU - Richards, Catherine AU - Sircar, Neelanjan AU - Weiss, Christopher PY - 2009 SP - 442 EP - 447 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Foods KW - Obesity KW - Density KW - Bismaleimides KW - Stores KW - Outlets KW - Land use KW - Population density KW - Health KW - Supermarkets KW - Lances KW - Adults KW - Confidence intervals KW - Quartiles KW - Vegetables KW - Construction KW - Multilevel KW - Copyrights KW - Marketing KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743325014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Neighborhood+Food+Environment+and+Walkability+Predict+Obesity+in+New+York+City&rft.au=Rundle%2C+Andrew%3BNeckerman%2C+Kathryn+M%3BFreeman%2C+Lance%3BLovasi%2C+Gina+S%3BPurciel%2C+Marnie%3BQuinn%2C+James%3BRichards%2C+Catherine%3BSircar%2C+Neelanjan%3BWeiss%2C+Christopher&rft.aulast=Rundle&rft.aufirst=Andrew&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Methylmercury Exposure and Adverse Cardiovascular Effects in Faroese Whaling Men AN - 743309340; 201004-31-0313618 (CE); 12122619 (EN) AB - BACKGROUND: Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. OBJECTIVE: We examined 42 Faroese whaling men (30-70 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whale meat. METHODS: We assessed exposure levels from mercury analysis of toenails and whole blood (obtained at the time of clinical examination), and a hair sample collected 7 years previously. Outcome measures included heart rate variability (HRV), blood pressure (BP), common carotid intima-media thickness (IMT), and brainstem auditory evoked potentials (BAEP). We carried out multiple regression and structural equation model (SEM) analyses to determine the confounder-adjusted effect of mercury exposure. Taking into account correlations among related measures, we categorized exposure and outcomes in groups to derive latent exposure and response variables in SEMs. We used multiple regression analysis to compare the predictive validity of individual exposure biomarkers and the latent exposure variable on individual and latent outcomes. RESULTS: The toenail mercury concentrations varied widely and had a geometric mean of 2.0 microg/g; hair concentrations averaged about 3-fold higher. Mercury exposure was significantly associated with increased BP and IMT. This effect was reflected by SEMs, but mercury in toenails tended to be the best effect predictor. CONCLUSIONS: The results support the notion that increased MeHg exposure promotes the development of cardiovascular disease. JF - Environmental Health Perspectives AU - Choi, Anna L AU - Weihe, Pal AU - Budtz-Joergensen, Esben AU - Joergensen, Poul J AU - Salonen, Jukka T AU - Tuomainen, Tomi-Pekka AU - Murata, Katsuyuki AU - Nielsen, Petur AU - Petersen, Maria Skaalum AU - Askham, Jorun AU - Grandjean, Philippe PY - 2009 SP - 367 EP - 372 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mathematical models KW - Mercury KW - Scanning electron microscopy KW - Regression analysis KW - Whaling KW - Health KW - Back propagation KW - Men KW - Hair KW - Heart rate KW - Seafood KW - Regression KW - Risk KW - Auditory evoked potential KW - Contaminants KW - Mortality KW - Mathematical analysis KW - Fish KW - Multiple regression analysis KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743309340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Methylmercury+Exposure+and+Adverse+Cardiovascular+Effects+in+Faroese+Whaling+Men&rft.au=Choi%2C+Anna+L%3BWeihe%2C+Pal%3BBudtz-Joergensen%2C+Esben%3BJoergensen%2C+Poul+J%3BSalonen%2C+Jukka+T%3BTuomainen%2C+Tomi-Pekka%3BMurata%2C+Katsuyuki%3BNielsen%2C+Petur%3BPetersen%2C+Maria+Skaalum%3BAskham%2C+Jorun%3BGrandjean%2C+Philippe&rft.aulast=Choi&rft.aufirst=Anna&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Impact of the Spanish Smoking Law on Exposure to Secondhand Smoke in Offices and Hospitality Venues: Before-and-After Study AN - 743297673; 201004-31-0313614 (CE); 12122615 (EN) AB - BACKGROUND/OBJECTIVES: A smoking law was passed by the Spanish Parliament in December 2005 and was enforced by 1 January 2006. The law bans smoking in all indoor workplaces but only in some hospitality venues, because owners are allowed to establish a smoking zone (venues100 m2) or to allow smoking without restrictions (venues100 m2). The objective of the study is to assess the impact of the Spanish smoking law on exposure to secondhand smoke (SHS) in enclosed workplaces, including hospitality venues. MATERIALS AND METHODS: The study design is a before-and-after evaluation. We studied workplaces and hospitality venues from eight different regions of Spain. We took repeated samples of vapor-phase nicotine concentration in 398 premises, including private offices (162), public administration offices (90), university premises (43), bars and restaurants (79), and discotheques and pubs (24). RESULTS: In the follow-up period, SHS levels were markedly reduced in indoor offices. The median decrease in nicotine concentration ranged from 60.0% in public premises to 97.4% in private areas. Nicotine concentrations were also markedly reduced in bars and restaurants that became smoke-free (96.7%) and in the no-smoking zones of venues with separate spaces for smokers (88.9%). We found no significant changes in smoking zones or in premises allowing smoking, including discotheques and pubs. CONCLUSIONS: Overall, this study shows the positive impact of the law on reducing SHS in indoor workplaces. However, SHS was substantially reduced only in bars and restaurants that became smoke-free. Most hospitality workers continue to be exposed to very high levels of SHS. Therefore, a 100% smoke-free policy for all hospitality venues is required. JF - Environmental Health Perspectives AU - Nebot, Manel AU - Lopez, Maria J AU - Ariza, Carles AU - Perez-Rios, Monica AU - Fu, Marcela AU - Schiaffino, Anna AU - Munoz, Gloria AU - Salto, Esteve AU - Fernandez, Esteve PY - 2009 SP - 344 EP - 347 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Smoking KW - Self-propagating synthesis KW - Law KW - Offices KW - Workplaces KW - Indoor KW - Restaurants KW - Bars KW - Nicotine KW - Smoke KW - Discotheques KW - Health KW - Policies KW - Public administration KW - Copyrights KW - Maria KW - Constrictions KW - Exposure KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743297673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Impact+of+the+Spanish+Smoking+Law+on+Exposure+to+Secondhand+Smoke+in+Offices+and+Hospitality+Venues%3A+Before-and-After+Study&rft.au=Nebot%2C+Manel%3BLopez%2C+Maria+J%3BAriza%2C+Carles%3BPerez-Rios%2C+Monica%3BFu%2C+Marcela%3BSchiaffino%2C+Anna%3BMunoz%2C+Gloria%3BSalto%2C+Esteve%3BFernandez%2C+Esteve&rft.aulast=Nebot&rft.aufirst=Manel&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Manganese Neurotoxicity: Lessons Learned from Longitudinal Studies in Nonhuman Primates AN - 743295187; 201004-31-0313621 (CE); 12122622 (EN) AB - BACKGROUND: Exposure to excess levels of the essential trace element manganese produces cognitive, psychiatric, and motor abnormalities. The understanding of Mn neurotoxicology is heavily governed by pathologic and neurochemical observations derived from rodent studies that often employ acute Mn exposures. The comparatively sparse studies incorporating in vivo neuroimaging in nonhuman primates provide invaluable insights on the effects of Mn on brain chemistry. OBJECTIVES: The purpose of this review is to discuss important aspects of Mn neurotoxicology and to synthesize recent findings from one of the largest cohorts of nonhuman primates used to study the neurologic effects of chronic Mn exposure. DISCUSSION: We reviewed our recent in vivo and ex vivo studies that have significantly advanced the understanding of Mn-induced neurotoxicity. In those studies, we administered weekly doses of 3.3-5.0 (n=4), 5.0-6.7 (n=5), or 8.3-10.0 mg Mn/kg (n=3) for 7-59 weeks to cynomolgus macaque monkeys. Animals expressed subtle deficits in cognition and motor function and decreases in the N-acetylaspartate-to-creatine ratio in the parietal cortex measured by magnetic resonance spectroscopy reflective of neuronal dysfunction. Impaired striatal dopamine release measured by positron emission tomography was observed in the absence of changes in markers of dopamine neuron degeneration. Neuropathology indicated decreased glutamine synthetase expression in the globus pallidus with otherwise normal markers of glutamatergic and GABAergic neurotransmission. Increased amyloid beta (A4) precursor-like protein 1 gene expression with multiple markers of neurodegeneration and glial cell activation was observed in the frontal cortex. CONCLUSIONS: These findings provide new information on mechanisms by which Mn affects behavior, neurotransmitter function, and neuropathology in nonhuman primates. JF - Environmental Health Perspectives AU - Burton, Neal C AU - Guilarte, Tomas R PY - 2009 SP - 325 EP - 332 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Manganese KW - Primates KW - Markers KW - Surgical implants KW - Biomedical materials KW - Health KW - Dopamine KW - In vivo tests KW - In vivo testing KW - Cortexes KW - Motors KW - Biocompatibility KW - Activation KW - Neurotransmitters KW - Monkeys KW - Cognition KW - Beta KW - Gene expression KW - Magnetic resonance KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743295187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Manganese+Neurotoxicity%3A+Lessons+Learned+from+Longitudinal+Studies+in+Nonhuman+Primates&rft.au=Burton%2C+Neal+C%3BGuilarte%2C+Tomas+R&rft.aulast=Burton&rft.aufirst=Neal&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Ultraviolet Photolysis of Chlorpyrifos: Developmental Neurotoxicity Modeled in PC12 Cells AN - 743281483; 201004-31-0313620 (CE); 12122621 (EN) AB - BACKGROUND: Ultraviolet photodegradation products from pesticides form both in the field and during water treatment. OBJECTIVES: We evaluated the photolytic breakdown of the organophosphate pesticide chlorpyrifos (CPF) in terms of both the chemical entities generated by low-pressure ultraviolet C irradiation and their potential as developmental neurotoxicants. METHODS: We separated by-products using high-performance liquid chromatography and characterized them by gas chromatography/mass spectrometry. We assessed neurotoxicity in neuronotypic PC12 cells, both in the undifferentiated state and during differentiation. RESULTS: Photodegradation of CPF in methanol solution generated CPF oxon and trichloropyridinol, products known to retain developmental neurotoxicant actions, as well as a series of related organophosphate and phosphorothionate derivatives. Exposure conditions that led to 50% degradation of CPF thus did not reduce developmental neurotoxicity. The degradation mixture inhibited DNA synthesis in undifferentiated cells to the same extent as native CPF. In differentiating cells, the products likewise retained the full ability to elicit shortfalls in cell number and corresponding effects on cell growth and neurite formation. When the exposure was prolonged to the point where 70% of the CPF was degraded, the adverse effects on PC12 cells were no longer evident; however, these conditions were sufficiently severe to generate toxic products from the methanol vehicle. CONCLUSIONS: Our results indicate that field conditions or remediation treatments that degrade a significant proportion of the CPF do not necessarily produce inactive products and, indeed, may elicit formation of even more toxic chemicals that are more water soluble and thus have greater field mobility than CPF itself. JF - Environmental Health Perspectives AU - Slotkin, Theodore A AU - Seidler, Frederic J AU - Wu, Changlong AU - MacKillop, Emiko A AU - Linden, Karl G PY - 2009 SP - 338 EP - 343 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Degradation KW - Methyl alcohol KW - Ultraviolet KW - Byproducts KW - Chlorpyrifos KW - Toxic KW - Health KW - Mathematical models KW - Pesticides KW - Organophosphates KW - Photodegradation KW - Toxicology KW - Liquid chromatography KW - Derivatives KW - Remediation KW - Mass spectrometry KW - Differentiation KW - Synthesis KW - Copyrights KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743281483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Ultraviolet+Photolysis+of+Chlorpyrifos%3A+Developmental+Neurotoxicity+Modeled+in+PC12+Cells&rft.au=Slotkin%2C+Theodore+A%3BSeidler%2C+Frederic+J%3BWu%2C+Changlong%3BMacKillop%2C+Emiko+A%3BLinden%2C+Karl+G&rft.aulast=Slotkin&rft.aufirst=Theodore&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Mechanisms of Inhaled Fine Particulate Air Pollution-Induced Arterial Blood Pressure Changes AN - 743276890; 201004-31-0313617 (CE); 12122618 (EN) AB - BACKGROUND: Epidemiologic studies suggest a positive association between fine particulate matter and arterial blood pressure, but the results have been inconsistent. OBJECTIVES: We investigated the effect of ambient particles on systemic hemodynamics during a 5-hr exposure to concentrated ambient air particles (CAPs) or filtered air (FA) in conscious canines. METHODS: Thirteen dogs were repeatedly exposed via permanent tracheostomy to CAPs (358.1+/-306.7 microg/m3, mean+/-SD) or FA in a crossover protocol (55 CAPs days, 63 FA days). Femoral artery blood pressure was monitored continuously via implanted telemetry devices. We measured baroreceptor reflex sensitivity before and after exposure in a subset of these experiments (n=10 dogs, 19 CAPs days, 20 FA days). In additional experiments, we administered alpha-adrenergic blockade before exposure (n=8 dogs, 16 CAPs days, 15 FA days). Blood pressure, heart rate, rate-pressure product, and baroreceptor reflex sensitivity responses were compared using linear mixed-effects models. RESULTS: CAPs exposure increased systolic blood pressure (2.7+/-1.0 mmHg, p=0.006), diastolic blood pressure (4.1+/-0.8 mmHg; p0.001), mean arterial pressure (3.7+/-0.8 mmHg; p0.001), heart rate (1.6+/-0.5 bpm; p0.001), and rate-pressure product (539+/-110 bpm x mmHg; p0.001), and decreased pulse pressure (-1.7+/-0.7 mmHg, p=0.02). These changes were accompanied by a 20+/-6 msec/mmHg (p=0.005) increase in baroreceptor reflex sensitivity after CAPs versus FA. After alpha-adrenergic blockade, responses to CAPs and FA no longer differed significantly. CONCLUSIONS: Controlled exposure to ambient particles elevates arterial blood pressure. Increased peripheral vascular resistance may mediate these changes, whereas increased baroreceptor reflex sensitivity may compensate for particle-induced alterations in blood pressure. JF - Environmental Health Perspectives AU - Bartoli, Carlo R AU - Wellenius, Gregory A AU - Diaz, Edgar A AU - Lawrence, Joy AU - Coull, Brent A AU - Akiyama, Ichiro AU - Lee, Lani M AU - Okabe, Kazunori AU - Verrier, Richard L AU - Goldleski, John J PY - 2009 SP - 361 EP - 366 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Blood pressure KW - Baroreceptors KW - Reflexes KW - Dogs KW - Heart rate KW - Blocking KW - Health KW - Hemodynamics KW - Copyrights KW - Telemetry KW - Alterations KW - Crossovers KW - Devices KW - Epidemiology KW - Mathematical models KW - Exposure KW - Arteries KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743276890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Mechanisms+of+Inhaled+Fine+Particulate+Air+Pollution-Induced+Arterial+Blood+Pressure+Changes&rft.au=Bartoli%2C+Carlo+R%3BWellenius%2C+Gregory+A%3BDiaz%2C+Edgar+A%3BLawrence%2C+Joy%3BCoull%2C+Brent+A%3BAkiyama%2C+Ichiro%3BLee%2C+Lani+M%3BOkabe%2C+Kazunori%3BVerrier%2C+Richard+L%3BGoldleski%2C+John+J&rft.aulast=Bartoli&rft.aufirst=Carlo&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Elevated Human Telomerase Reverse Transcriptase Gene Expression in Blood Cells Associated with Chronic Arsenic Exposure in Inner Mongolia, China AN - 743272962; 201004-31-0313616 (CE); 12122617 (EN) AB - BACKGROUND: Arsenic exposure is associated with human cancer. Telomerase-containing human telomerase reverse transcriptase (hTERT) can extend telomeres of chromosomes, delay senescence, and promote cell proliferation leading to tumorigenesis. OBJECTIVE: The goal of this study was to investigate the effects of As on hTERT mRNA expression in humans and in vitro. METHOD: A total of 324 Inner Mongolia residents who have been exposed to As via drinking water participated in this study. Water and toenail samples were collected and analyzed for As. Blood samples were quantified for hTERT mRNA expression using real-time polymerase chain reaction. The hTERT mRNA levels were linked to water and nail As concentrations and skin hyperkeratosis. Human epidermal keratinocytes were treated with arsenite to assess effects on cell viability and hTERT expression in vitro. RESULTS: hTERT mRNA expression levels were significantly associated with As concentrations of water (p0.0001) and nails (p=0.002) and also associated with severity of skin hyperkeratosis (p0.05), adjusting for age, sex, smoking, and pesticide use. Females showed a higher slope than males (females: 0.126, p=0.0005; males: 0.079, p=0.017). In addition to water and nail As concentrations, age (p0.0001) and pesticide use (p=0.025) also showed significant associations with hTERT expression. The hTERT expression levels decreased with age. Tobacco smoking did not affect hTERT expression (p=0.13). hTERT expression was significantly correlated with OGG1 and ERCC1 expression. The in vitro results also showed a dose-response relationship between arsenite concentrations and hTERT expression and reached the peak at 1 microM. CONCLUSIONS: hTERT expression was associated with As exposure in vivo and in vitro. The increased hTERT expression may be a cellular response to genomic insults by As and may also indicate that As may function as a tumor promoter in carcinogenesis in humans. JF - Environmental Health Perspectives AU - Mo, Jinyao AU - Xia, Yajuan AU - Ning, Zhixiong AU - Wade, Timothy J AU - Mumford, Judy L PY - 2009 SP - 354 EP - 360 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Human KW - In vitro testing KW - Drinking water KW - Age KW - Nails KW - Telomerase KW - Health KW - Pesticides KW - Males KW - Females KW - Smoking KW - Arsenic KW - Cellular KW - Carcinogens KW - Gene expression KW - Delay KW - Surgical implants KW - Correlation KW - Chromosomes KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743272962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Elevated+Human+Telomerase+Reverse+Transcriptase+Gene+Expression+in+Blood+Cells+Associated+with+Chronic+Arsenic+Exposure+in+Inner+Mongolia%2C+China&rft.au=Mo%2C+Jinyao%3BXia%2C+Yajuan%3BNing%2C+Zhixiong%3BWade%2C+Timothy+J%3BMumford%2C+Judy+L&rft.aulast=Mo&rft.aufirst=Jinyao&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Lactational Exposure to Polychlorinated Biphenyls, Dichlorodiphenyltrichloroethane, and Dichlorodiphenyldichloroethylene and Infant Neurodevelopment: An Analysis of the Pregnancy, Infection, and Nutrition Babies Study AN - 743254832; 201004-31-0313599 (CE); 12122600 (EN) AB - BACKGROUND: Polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT) are persistent, bioaccumulative, and toxic pollutants that were broadly used in the United States until the 1970s. Common exposure to PCBs, DDT, and dichlorodiphenyldichloroethylene (DDE), the most stable metabolite of DDT, may influence children's neurodevelopment, but study results are not consistent. OBJECTIVES: We examined the associations between lactational exposure to PCBs, DDT, and DDE and infant development at 12 months, using data from the Pregnancy, Infection, and Nutrition Babies Study, 2004-2006. METHODS: We measured PCBs, DDT, and DDE in breast milk at the third month postpartum. Lactational exposure of these chemicals was estimated by the product of chemical concentrations and the duration of breast-feeding. Infant development at 12 months of age was measured by the Mullen Scales of Early Learning (n=231) and the Short Form: Level I (infant) of the MacArthur-Bates Communicative Development Indices (n=218). RESULTS: No consistent associations were observed between lactational exposure to PCBs, DDT, and DDE through the first 12 months and the measures of infant development. However, DDE was associated with scoring below average on the gross motor scale of the Mullen among males only (adjusted odds ratio=1.9; 95% confidence interval, 1.1-3.3). CONCLUSION: Infant neurodevelopment at 12 months of age was not impaired by PCBs, DDT, and DDE at the concentrations measured here, in combination with benefits from long duration of breast-feeding in this population. JF - Environmental Health Perspectives AU - Pan, I-Jen AU - Daniels, Julie L AU - Goldman, Barbara D AU - Herring, Amy H AU - Siega-Riz, Anna Maria AU - Rogan, Walter J PY - 2009 SP - 488 EP - 494 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - DDT KW - Infants KW - Nutrition KW - Pregnancy KW - Health KW - Polychlorinated biphenyls KW - Age KW - Babies KW - Milk KW - Breast KW - Children KW - Metabolites KW - Toxic KW - Confidence intervals KW - Scoring KW - Males KW - Copyrights KW - Maria KW - Motors KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743254832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Lactational+Exposure+to+Polychlorinated+Biphenyls%2C+Dichlorodiphenyltrichloroethane%2C+and+Dichlorodiphenyldichloroethylene+and+Infant+Neurodevelopment%3A+An+Analysis+of+the+Pregnancy%2C+Infection%2C+and+Nutrition+Babies+Study&rft.au=Pan%2C+I-Jen%3BDaniels%2C+Julie+L%3BGoldman%2C+Barbara+D%3BHerring%2C+Amy+H%3BSiega-Riz%2C+Anna+Maria%3BRogan%2C+Walter+J&rft.aulast=Pan&rft.aufirst=I-Jen&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats AN - 743186148; 201004-31-0313610 (CE); 12122611 (EN) AB - BACKGROUND: Neurodevelopmental disorders are associated with altered patterns of neuronal connectivity. A critical determinant of neuronal connectivity is the dendritic morphology of individual neurons, which is shaped by experience. The identification of environmental exposures that interfere with dendritic growth and plasticity may, therefore, provide insight into environmental risk factors for neurodevelopmental disorders. OBJECTIVE: We tested the hypothesis that polychlorinated biphenyls (PCBs) alter dendritic growth and/or plasticity by promoting the activity of ryanodine receptors (RyRs). METHODS AND RESULTS: The Morris water maze was used to induce experience-dependent neural plasticity in weanling rats exposed to either vehicle or Aroclor 1254 (A1254) in the maternal diet throughout gestation and lactation. Developmental A1254 exposure promoted dendritic growth in cerebellar Purkinje cells and neocortical pyramidal neurons among untrained animals but attenuated or reversed experience-dependent dendritic growth among maze-trained littermates. These structural changes coincided with subtle deficits in spatial learning and memory, increased [3H]-ryanodine binding sites and RyR expression in the cerebellum of untrained animals, and inhibition of training-induced RyR upregulation. A congener with potent RyR activity, PCB95, but not a congener with negligible RyR activity, PCB66, promoted dendritic growth in primary cortical neuron cultures and this effect was blocked by pharmacologic antagonism of RyR activity. CONCLUSIONS: Developmental exposure to PCBs interferes with normal patterns of dendritic growth and plasticity, and these effects may be linked to changes in RyR expression and function. These findings identify PCBs as candidate environmental risk factors for neurodevelopmental disorders, especially in children with heritable deficits in calcium signaling. JF - Environmental Health Perspectives AU - Yang, Dongren AU - Kim, Kyung Ho AU - Phimister, Andrew AU - Bachstetter, Adam D AU - Ward, Thomas R AU - Stackman, Robert W AU - Mervis, Ronald F AU - Wisniewski, Amy B AU - Klein, Sabra L AU - Kodavanti, Prasada Rao S AU - Anderson, Kim A AU - Wayman, Gary AU - Pessah, Isaac N AU - Lein, Pamela J PY - 2009 SP - 426 EP - 435 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Plasticity KW - Disorders KW - Neurons KW - Gestation KW - Risk KW - Health KW - Receptors KW - Congeners KW - Polychlorinated biphenyls KW - Animals KW - Rats KW - Cerebellum KW - Children KW - Morphology KW - Binding sites KW - Culture KW - Determinants KW - Calcium KW - Inhibition KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743186148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Developmental+Exposure+to+Polychlorinated+Biphenyls+Interferes+with+Experience-Dependent+Dendritic+Plasticity+and+Ryanodine+Receptor+Expression+in+Weanling+Rats&rft.au=Yang%2C+Dongren%3BKim%2C+Kyung+Ho%3BPhimister%2C+Andrew%3BBachstetter%2C+Adam+D%3BWard%2C+Thomas+R%3BStackman%2C+Robert+W%3BMervis%2C+Ronald+F%3BWisniewski%2C+Amy+B%3BKlein%2C+Sabra+L%3BKodavanti%2C+Prasada+Rao+S%3BAnderson%2C+Kim+A%3BWayman%2C+Gary%3BPessah%2C+Isaac+N%3BLein%2C+Pamela+J&rft.aulast=Yang&rft.aufirst=Dongren&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Diesel Exhaust Particles Activate the Matrix -Metalloproteinase-1 Gene in Human Bronchial Epithelia in a [beta]-Arrestin-Dependent Manner via Activation of RAS AN - 743177456; 201004-31-0313595 (CE); 12122455 (EN) AB - BACKGROUND: Diesel exhaust particles (DEPs) are globally relevant air pollutants that exert a detrimental human health impact. However, mechanisms of damage by DEP exposure to human respiratory health and human susceptibility factors are only partially known. Matrix metalloproteinase-1 (MMP-1) has been implied as an (etio)pathogenic factor in human lung and airway diseases such as emphysema, chronic obstructive pulmonary disease, chronic asthma, tuberculosis, and bronchial carcinoma and has been reported to be regulated by DEPs. OBJECTIVE: We elucidated the molecular mechanisms of DEPs' up-regulation of MMP-1. METHODS/RESULTS: Using permanent and primary human bronchial epithelial (HBE) cells at air-liquid interface, we show that DEPs activate the human MMP-1 gene via RAS and subsequent activation of RAF-MEK-ERK1/2 mitogen-activated protein kinase signaling, which can be scaffolded by beta-arrestins. Short interfering RNA mediated beta-arrestin1/2 knockout eliminated formation, subsequent nuclear trafficking of phosphorylated ERK1/2, and resulting MMP-1 transcriptional activation. Transcriptional regulation of the human MMP-1 promoter was strongly influenced by the presence of the -1607GG polymorphism, present in 60-80% of humans, which led to striking up-regulation of MMP-1 transcriptional activation. CONCLUSION: Our results confirm up-regulation of MMP-1 in response to DEPs in HBE and provide new mechanistic insight into how these epithelia, the first line of protection against environmental insults, up-regulate MMP-1 in response to DEP inhalation. These mechanisms include a role for the human -1607GG polymorphism as a susceptibility factor for an accentuated response, which critically depends on the ability of beta-arrestin1/2 to generate scaffolding and nuclear trafficking of phosphorylated ERK1/2. JF - Environmental Health Perspectives AU - Li, Jinju AU - Ghio, Andrew J AU - Cho, Seung-Hyun AU - Brinckethoff, Constance E AU - Simon, Sidney A AU - Liedtke, Wolfgang PY - 2009 SP - 400 EP - 409 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Human KW - Activation KW - Health KW - Diseases KW - Diesel KW - Diesel fuels KW - Kinases KW - Genes KW - Polymorphism KW - Exhaust KW - Asthma KW - Ribonucleic acids KW - Emphysema KW - Damage KW - Tuberculosis KW - Airways KW - Copyrights KW - Scaffolding KW - Lungs KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743177456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Diesel+Exhaust+Particles+Activate+the+Matrix+-Metalloproteinase-1+Gene+in+Human+Bronchial+Epithelia+in+a+%5Bbeta%5D-Arrestin-Dependent+Manner+via+Activation+of+RAS&rft.au=Li%2C+Jinju%3BGhio%2C+Andrew+J%3BCho%2C+Seung-Hyun%3BBrinckethoff%2C+Constance+E%3BSimon%2C+Sidney+A%3BLiedtke%2C+Wolfgang&rft.aulast=Li&rft.aufirst=Jinju&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=400&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Activated Toxicity of Diesel Particulate Extract by Ultraviolet A Radiation in Mammalian Cells: Role of Singlet Oxygen AN - 743156968; 201004-31-0313606 (CE); 12122607 (EN) AB - BACKGROUND: Diesel exhaust [diesel exhaust particles (DEPs) and their extracts (DPE)] and ultraviolet A radiation (UVA) are two ubiquitous environmental factors that have been identified as essential risk factors for various benign or malignant human diseases, either alone or in combination with other agents. OBJECTIVES: We aimed to investigate the synergistic effects of DPE and UVA at low-dose exposures in human-hamster hybrid (AL) cells and their underlying mechanisms. METHODS: We exposed exponentially growing AL cells to DPE and/or UVA radiation with or without reactive oxygen species (ROS) quenchers and then assayed the cells for survival, mutation induction, apoptosis, and micronucleus generation. In addition, using a singlet oxygen (1O2) trapping probe, 2,2,6,6-tetramethyl-4-piperidone, coupled with electron paramagnetic resonance spectroscopy, we determined the production of 1O2. RESULTS: Treatment of AL cells with DPE+UVA induced significant cytotoxic and genotoxic damage. In contrast, we found no significant damage in cells treated with either UVA or DPE alone at the same doses. Mutation spectra of CD59- mutants showed that treatment with DPE+UVA easily induces multilocus deletions. Sodium azide significantly inhibited both cellular and DNA damage induced by DPE+UVA treatment, whereas other ROS inhibitors had little protecting effect. Furthermore, we found a significant increase of 1O2 in the cells that received DPE+UVA treatment. CONCLUSION: These findings suggest that UVA activated the genotoxicity and cytotoxicity of DPE in mammalian cells and that 1O2 played an important role in these processes. JF - Environmental Health Perspectives AU - Bao, Lingzhi AU - Xu, An AU - Tong, Liping AU - Chen, Shaopeng AU - Zhu, Lingyan AU - Zhao, Ye AU - Zhao, Guoping AU - Jiang, Erkang AU - Wang, Jun AU - Wu, Lijun PY - 2009 SP - 436 EP - 441 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Diesel KW - Diesel fuels KW - Damage KW - Inhibitors KW - Ultraviolet KW - Singlet oxygen KW - Mutations KW - Health KW - Activated KW - Genotoxicity KW - Exhaust KW - Exposure KW - Trapping KW - Cellular KW - Toxicity KW - Diseases KW - Background radiation KW - Risk KW - Electron paramagnetic resonance KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743156968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Activated+Toxicity+of+Diesel+Particulate+Extract+by+Ultraviolet+A+Radiation+in+Mammalian+Cells%3A+Role+of+Singlet+Oxygen&rft.au=Bao%2C+Lingzhi%3BXu%2C+An%3BTong%2C+Liping%3BChen%2C+Shaopeng%3BZhu%2C+Lingyan%3BZhao%2C+Ye%3BZhao%2C+Guoping%3BJiang%2C+Erkang%3BWang%2C+Jun%3BWu%2C+Lijun&rft.aulast=Bao&rft.aufirst=Lingzhi&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Concentrated Ambient Particles Alter Myocardial Blood Flow during Acute Ischemia in Conscious Canines AN - 743138453; 201004-31-0313619 (CE); 12122620 (EN) AB - BACKGROUND: Experimental and observational studies have demonstrated that short-term exposure to ambient particulate matter (PM) exacerbates myocardial ischemia. OBJECTIVES: We conducted this study to investigate the effects of concentrated ambient particles (CAPs) on myocardial blood flow during myocardial ischemia in chronically instrumented conscious canines. METHODS: Eleven canines were instrumented with a balloon occluder around the left anterior descending coronary artery and catheters for determination of myocardial blood flow using fluorescent microspheres. Telemetric electrocardiographic and blood pressure monitoring was available for four of these animals. After recovery, we exposed animals by inhalation to 5 hr of either filtered air or CAPs (mean concentration+/-SD, 349.0+/-282.6 microg/m3) in a crossover protocol. We determined myocardial blood flow during a 5-min coronary artery occlusion immediately after each exposure. Data were analyzed using mixed models for repeated measures. The primary analysis was based on four canines that completed the protocol. RESULTS: CAPs exposure decreased total myocardial blood flow during coronary artery occlusion by 0.12 mL/min/g (p0.001) and was accompanied by a 13% (p0.001) increase in coronary vascular resistance. Rate-pressure product, an index of myocardial oxygen demand, did not differ by exposure (p=0.90). CAPs effects on myocardial blood flow were significantly more pronounced in myocardium within or near the ischemic zone versus more remote myocardium (p interaction0.001). CONCLUSIONS: These results suggest that PM exacerbates myocardial ischemia by increased coronary vascular resistance and decreased myocardial perfusion. Further studies are needed to elucidate the mechanism of these effects. JF - Environmental Health Perspectives AU - Bartoli, Carlo R AU - Wellenius, Gregory A AU - Coull, Brent A AU - Akiyama, Ichiro AU - Diaz, Edgar A AU - Lawrence, Joy AU - Okabe, Kazunori AU - Verrier, Richard L AU - Godleski, John J PY - 2009 SP - 333 EP - 337 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 3 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Blood flow KW - Ischemia KW - Arteries KW - Myocardium KW - Health KW - Occlusion KW - Animals KW - Oxygen demand KW - Crossovers KW - Mathematical models KW - Balloons KW - Monitoring KW - Copyrights KW - Recovery KW - Catheters KW - Blood pressure KW - Inhalation KW - Microspheres KW - Exposure KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743138453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Concentrated+Ambient+Particles+Alter+Myocardial+Blood+Flow+during+Acute+Ischemia+in+Conscious+Canines&rft.au=Bartoli%2C+Carlo+R%3BWellenius%2C+Gregory+A%3BCoull%2C+Brent+A%3BAkiyama%2C+Ichiro%3BDiaz%2C+Edgar+A%3BLawrence%2C+Joy%3BOkabe%2C+Kazunori%3BVerrier%2C+Richard+L%3BGodleski%2C+John+J&rft.aulast=Bartoli&rft.aufirst=Carlo&rft.date=2009-03-01&rft.volume=117&rft.issue=3&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Blood lead, serum homocysteine, and neurobehavioral test performance in the third National Health and Nutrition Examination Survey. AN - 733097536; 19459225 AB - Regression analysis was used to estimate and test for relationships between blood lead, serum folate, red blood cell folate, serum vitamin B12, serum homocysteine, and neurobehavioral test performance in adults, 20-59 years old, participating in the third National Health and Nutrition Examination Survey. The three neurobehavioral tests included in the survey were simple reaction time, symbol-digit substitution, and serial digit learning. Serum folate, red blood cell folate, and serum vitamin B12 decreased as the blood lead concentration increased. Serum homocysteine increased as the blood lead concentration increased. Serum homocysteine decreased as the serum folate and serum vitamin B12 concentrations increased. Neurobehavioral test performance was not related to the blood lead, serum folate, or serum vitamin B12 concentrations. In adults 20-39 years old, performance on the serial digit learning test improved as the serum homocysteine concentration increased. In adults 40-59 years old, neurobehavioral test performance was not related to the serum homocysteine concentration. Homocysteine may impair cognitive function by acting at N-methyl-D-aspartate receptors, and improve cognitive function by acting at N-methyl-D-aspartate or gamma-aminobutyric acid receptors. JF - Neurotoxicology AU - Krieg, Edward F AU - Butler, Mary Ann AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. erk3@cdc.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 281 EP - 289 VL - 30 IS - 2 KW - Homocysteine KW - 0LVT1QZ0BA KW - Lead KW - 2P299V784P KW - Index Medicus KW - United States KW - Young Adult KW - Humans KW - Lead Poisoning, Nervous System, Adult -- diagnosis KW - Reaction Time -- physiology KW - Photic Stimulation -- methods KW - Lead Poisoning, Nervous System, Adult -- blood KW - Lead Poisoning, Nervous System, Adult -- psychology KW - Adult KW - Health Surveys KW - Middle Aged KW - Neuropsychological Tests KW - Female KW - Male KW - Homocysteine -- blood KW - Nutrition Surveys KW - Lead -- blood KW - Psychomotor Performance -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733097536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Blood+lead%2C+serum+homocysteine%2C+and+neurobehavioral+test+performance+in+the+third+National+Health+and+Nutrition+Examination+Survey.&rft.au=Krieg%2C+Edward+F%3BButler%2C+Mary+Ann&rft.aulast=Krieg&rft.aufirst=Edward&rft.date=2009-03-01&rft.volume=30&rft.issue=2&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=1872-9711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-01 N1 - Date created - 2009-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of irritancy and sensitization potential of metalworking fluid mixtures and components. AN - 67356308; 19519159 AB - There are approximately 1.2 million workers exposed to metalworking fluids (MWF), which are used to reduce the heat and friction associated with industrial machining and grinding operations. Irritancy and sensitization potential of 9 National Toxicology Program (NTP) nominated MWFs (TRIM 229, TRIM VX, TRIM SC210, CIMTECH 310, CIMPERIAL 1070, CIMSTAR 3800, SYNTILO 1023, SUPEREDGE 6768, and CLEAREDGE 6584) were examined in a combined local lymph node assay (LLNA). BALB/c mice were dermally exposed to each MWF at concentrations up to 50%. Significant irritation was observed after dermal exposure to all MWFs except CIMTECH 310 and SYNTILO 1023. Of the 9 MWFs, 6 induced greater than a 3-fold increase in lymphocyte proliferation and 7 tested positive in the irritancy assay. TRIM VX yielded the lowest EC3 value (6.9%) with respect to lymphocyte proliferation. Chemical components of TRIM VX identified using HPLC were screened for sensitization potential using structural activity relationship (SAR) modeling and the LLNA. TOPKAT predicted triethanolamine (TEA) as a sensitizer while Derek for Windows predicted only 4-chloro-3-methylphenol (CMP) to be positive for sensitization. When tested in the LLNA only CMP (EC3 = 11.6%) and oleic acid (OA) (EC3 = 29.7%) were identified as sensitizers. Exposure to all tested TRIM VX components resulted in statistically significant irritation. An additive proliferative response was observed when mixtures of the two identified sensitizing TRIM VX components, OA and CMP, were tested in the LLNA. This is one explanation of why the EC3 value of TRIM VX, with respect to lymphocyte proliferation, is lower than those assigned to its sensitizing components. JF - Journal of immunotoxicology AU - Anderson, Stacey E AU - Brown, Kenneth K AU - Butterworth, Leon F AU - Fedorowicz, Adam AU - Jackson, Laurel G AU - Frasch, H Fred AU - Beezhold, Don AU - Munson, Albert E AU - Meade, B J AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. sanderson4@cdc.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 19 EP - 29 VL - 6 IS - 1 KW - 3-methyl-4-chlorophenol KW - 0 KW - Allergens KW - Chlorophenols KW - Cyclohexenes KW - Ethanolamines KW - Irritants KW - Monoterpenes KW - Organic Chemicals KW - alpha-terpineol KW - 21334LVV8W KW - Oleic Acid KW - 2UMI9U37CP KW - triethanolamine KW - 9O3K93S3TK KW - Index Medicus KW - Allergens -- immunology KW - Cell Proliferation -- drug effects KW - Animals KW - Cyclohexenes -- pharmacology KW - Oleic Acid -- immunology KW - Ethanolamines -- pharmacology KW - Allergens -- toxicity KW - Chlorophenols -- pharmacology KW - Monoterpenes -- pharmacology KW - Mice KW - Mice, Inbred BALB C KW - Lymph Nodes -- cytology KW - Ear Auricle -- immunology KW - Structure-Activity Relationship KW - Chlorophenols -- immunology KW - Lymphocyte Activation -- drug effects KW - Ear Auricle -- drug effects KW - Lymphocyte Activation -- immunology KW - Ear Auricle -- pathology KW - Occupational Exposure -- adverse effects KW - Oleic Acid -- pharmacology KW - Lymph Nodes -- drug effects KW - Female KW - Lymph Nodes -- immunology KW - Skin Irritancy Tests KW - Dermatitis, Contact -- pathology KW - Organic Chemicals -- toxicity KW - Organic Chemicals -- immunology KW - Irritants -- toxicity KW - Dermatitis, Contact -- immunology KW - Irritants -- immunology KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67356308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotoxicology&rft.atitle=Evaluation+of+irritancy+and+sensitization+potential+of+metalworking+fluid+mixtures+and+components.&rft.au=Anderson%2C+Stacey+E%3BBrown%2C+Kenneth+K%3BButterworth%2C+Leon+F%3BFedorowicz%2C+Adam%3BJackson%2C+Laurel+G%3BFrasch%2C+H+Fred%3BBeezhold%2C+Don%3BMunson%2C+Albert+E%3BMeade%2C+B+J&rft.aulast=Anderson&rft.aufirst=Stacey&rft.date=2009-03-01&rft.volume=6&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotoxicology&rft.issn=1547-6901&rft_id=info:doi/10.1080%2F15476910802604291 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-05 N1 - Date created - 2009-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15476910802604291 ER - TY - JOUR T1 - Determination of bromine in regulated foods with a field-portable X-ray fluorescence analyzer. AN - 67327584; 19485210 AB - A field-portable X-ray fluorescence analyzer, factory-calibrated for soil analysis, was used to measure bromine (Br) mass fractions in reference materials, flour, bakery products, malted barley, selected U.S. Food and Drug Administration Total Diet Study foods, and other food products. By using a calibration based on instrumental neutron activation analysis results for Br in reference materials, accurate quantitative results, confirmed by z-scores, could be obtained for mass fractions of about 2-55 mg/kg. These results confirmed accuracy of results (with larger uncertainties) obtained by applying a simple correction factor to the analyzer's output value. Results showed that very short analysis times (<2 min) would be needed to screen foods for Br content at regulatory levels for brominated and enriched brominated flour (24 mg/kg Br) and whole wheat flour and bakery products (36 mg/kg Br). Feasibility for determination of Br in malted barley at the regulatory level (75 mg/kg Br) was demonstrated, but quantitative results at that level could not be assured because no reference material with a suitable mass fraction was available. Br mass fractions for all foods tested were well below regulatory levels. JF - Journal of AOAC International AU - Anderson, David L AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Chemical Contaminants Branch, HFS-716, 5100 Paint Branch Pkwy, College Park, MD 20740-3835, USA. david.anderson@fda.hhs.gov PY - 2009 SP - 502 EP - 510 VL - 92 IS - 2 SN - 1060-3271, 1060-3271 KW - Bromine KW - SBV4XY874G KW - Index Medicus KW - United States KW - Flour -- analysis KW - United States Food and Drug Administration KW - Edible Grain -- chemistry KW - Bread -- analysis KW - Spectrometry, X-Ray Emission -- instrumentation KW - Food Analysis -- standards KW - Food Analysis -- methods KW - Spectrometry, X-Ray Emission -- methods KW - Food Analysis -- instrumentation KW - Bromine -- analysis KW - Spectrometry, X-Ray Emission -- standards KW - Food Contamination -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67327584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Determination+of+bromine+in+regulated+foods+with+a+field-portable+X-ray+fluorescence+analyzer.&rft.au=Anderson%2C+David+L&rft.aulast=Anderson&rft.aufirst=David&rft.date=2009-03-01&rft.volume=92&rft.issue=2&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-01 N1 - Date created - 2009-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiresidue analysis of 102 organophosphorus pesticides in produce at parts-per-billion levels using a modified QuEChERS method and gas chromatography with pulsed flame photometric detection. AN - 67320210; 19485217 AB - A multiresidue method for the analysis of organophosphorus pesticides in fresh produce at levels down to 1.0 microg/kg (ppb) has been developed using a modification of the QuEChERS (quick, easy, cheap, effective, rugged, and safe) procedure. The procedure entails extraction of pesticides from the sample with acetonitrile, salting-out with magnesium sulfate (MgSO4) and sodium chloride, and cleanup of the resulting extracts with dispersive solid-phase extraction using primary-secondary amine, graphitized carbon black, and MgSO4. Fortification studies were performed for 102 organophosphorus pesticides at 1.0, 10, and 100 ppb in 4 different pesticide-free commodities (grape, orange, spinach, and tomato). Recoveries ranged from 63-125%, with >80% being achieved for most of the pesticides tested in each commodity. The procedure was applied to the analysis of 400 produce samples collected from a cohort of children that participated in the Children's Pesticide Exposure Study and the Longitudinal Dietary Pesticide Exposure Study in which selected 24 h duplicate food items were collected throughout a 12-month period. Residues of 15 of the 102 pesticides were detected at levels ranging from <1 to 526 ppb. JF - Journal of AOAC International AU - Schenck, Frank AU - Wong, Jon AU - Lu, Chenseng AU - Li, Jing AU - Holcomb, Jim R AU - Mitchell, LaTonya M AD - U.S. Food and Drug Administration, Office of Regulatory Affairs, 60 Eighth St NE, Atlanta, GA 30309, USA. fschenck@live.com PY - 2009 SP - 561 EP - 573 VL - 92 IS - 2 SN - 1060-3271, 1060-3271 KW - Organophosphorus Compounds KW - 0 KW - Pesticides KW - Index Medicus KW - Vegetables -- chemistry KW - Flame Ionization -- methods KW - Fruit -- chemistry KW - Pesticides -- analysis KW - Organophosphorus Compounds -- analysis KW - Food Contamination -- analysis KW - Solid Phase Microextraction -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67320210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Multiresidue+analysis+of+102+organophosphorus+pesticides+in+produce+at+parts-per-billion+levels+using+a+modified+QuEChERS+method+and+gas+chromatography+with+pulsed+flame+photometric+detection.&rft.au=Schenck%2C+Frank%3BWong%2C+Jon%3BLu%2C+Chenseng%3BLi%2C+Jing%3BHolcomb%2C+Jim+R%3BMitchell%2C+LaTonya+M&rft.aulast=Schenck&rft.aufirst=Frank&rft.date=2009-03-01&rft.volume=92&rft.issue=2&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-01 N1 - Date created - 2009-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Incomplete recoveries of fumonisins present in naturally contaminated corn foods from an immunoaffinity column. AN - 67319992; 19485209 AB - Following previous observations of apparent instability of fumonisin B1 in corn starch and corn meal, immunoaffinity column (IAC) cleanup, of the type used in the analysis of commercial starch-containing corn foods for fumonisins, was investigated. Foods analyzed for naturally occurring fumonisins B1, B2, and B3 included corn flour (3 different products), corn meal, and corn flakes. In 2 series of experiments, fractions were eluted by gravity or vacuum from narrow- or wide-bore Fumonitest IACs either with 2 x 2 mL methanol, followed by 2 mL methanol-water (8 + 2, v/v), or with 2 mL methanol, then 2 mL methanol-water (8 + 2, v/v). The ratio (%) of fumonisin B1 concentration in the first methanol eluate to the total concentration measured from all eluates in most cases varied from 25-70%. Incomplete recoveries were also observed for fumonisins B2 and B3. It is concluded that there can be a major underestimation of naturally occurring fumonisins in methods using only methanol elution for IAC cleanup, as in AOAC INTERNATIONAL Official Method 2001.04 (accuracy of these methods had been determined only by spiking the food with fumonisins). Elution with 2 x 2 mL methanol-water (8 + 2, v/v) was chosen as a practical procedure; means of 81-98% of the total fumonisin B1 concentration were found in the first eluate, except for corn flakes and 2 experiments with corn meal. JF - Journal of AOAC International AU - Oh, Keum Soon AU - Scott, Peter M AU - Chung, Soo-Hyun AD - Korea Food and Drug Administration, Department of Food Safety Evaluation, Seoul 122-704, Korea. PY - 2009 SP - 496 EP - 501 VL - 92 IS - 2 SN - 1060-3271, 1060-3271 KW - Fumonisins KW - 0 KW - Solvents KW - Water KW - 059QF0KO0R KW - fumonisin B2 KW - 116355-84-1 KW - fumonisin B3 KW - 136379-59-4 KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Methanol KW - Y4S76JWI15 KW - Index Medicus KW - Chromatography, High Pressure Liquid KW - Zea mays -- toxicity KW - Fumonisins -- isolation & purification KW - Zea mays -- chemistry KW - Food Contamination -- analysis KW - Fumonisins -- toxicity KW - Chromatography, Affinity -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67319992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Incomplete+recoveries+of+fumonisins+present+in+naturally+contaminated+corn+foods+from+an+immunoaffinity+column.&rft.au=Oh%2C+Keum+Soon%3BScott%2C+Peter+M%3BChung%2C+Soo-Hyun&rft.aulast=Oh&rft.aufirst=Keum&rft.date=2009-03-01&rft.volume=92&rft.issue=2&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-01 N1 - Date created - 2009-06-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J AOAC Int. 2009 Nov-Dec;92(6):203A N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative proteomics for drug toxicity. AN - 67168104; 19351682 AB - The emerging field of toxicoproteomics has been greatly advanced by quantitative proteomic technologies and their increasing applications in toxicology. The discipline is focused on the proteomic study of toxicity caused by toxic substances, including but not limited to drugs, toxins, environmental stressors, chemicals and any other materials that induce significant pathological responses. Drug safety is a major point of concern during the development phase and clinical application. Identification of toxicity biomarkers, potential drug targets and characterization of toxicity mechanisms represent major research areas for quantitative toxicoproteomics during drug development and evaluation. Further development and application of quantitative proteomic approaches would significantly facilitate the realization of personalized medicine. JF - Briefings in functional genomics & proteomics AU - Gao, Yuan AU - Holland, Ricky D AU - Yu, Li-Rong AD - Division of Systems Toxicology, Center for Proteomics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 158 EP - 166 VL - 8 IS - 2 KW - Biomarkers KW - 0 KW - Proteins KW - Proteome KW - Index Medicus KW - Protein Array Analysis KW - Animals KW - Technology, Pharmaceutical -- methods KW - Humans KW - Proteins -- analysis KW - Computational Biology KW - Drug Evaluation, Preclinical -- methods KW - Models, Biological KW - Drug Design KW - Genomics KW - Proteomics -- methods KW - Drug-Related Side Effects and Adverse Reactions KW - Biomarkers -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67168104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Briefings+in+functional+genomics+%26+proteomics&rft.atitle=Quantitative+proteomics+for+drug+toxicity.&rft.au=Gao%2C+Yuan%3BHolland%2C+Ricky+D%3BYu%2C+Li-Rong&rft.aulast=Gao&rft.aufirst=Yuan&rft.date=2009-03-01&rft.volume=8&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Briefings+in+functional+genomics+%26+proteomics&rft.issn=1477-4062&rft_id=info:doi/10.1093%2Fbfgp%2Felp006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-13 N1 - Date created - 2009-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/bfgp/elp006 ER - TY - JOUR T1 - FDA review of a panitumumab (Vectibix) clinical trial for first-line treatment of metastatic colorectal cancer. AN - 67085788; 19282350 AB - On September 27, 2006, the U.S. Food and Drug Administration granted accelerated approval to panitumumab (Vectibix; Amgen, Inc., Thousand Oaks, CA) for the treatment of patients with epidermal growth factor receptor-expressing, metastatic colorectal carcinoma with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Accelerated approval was based on demonstration of a beneficial effect on progression-free survival (PFS). The present submission summarizes a second clinical trial, to be included in the panitumumab package insert in June 2008, of chemotherapy and bevacizumab with and without panitumumab in the first-line treatment of patients with metastatic colorectal cancer. The study was closed when inferior PFS and greater toxicity were demonstrated at the time of the planned interim efficacy analysis. Patients receiving panitumumab in combination with bevacizumab and chemotherapy experienced a higher incidence of death (9% versus 4%) and a higher risk for grade 3 and 4 toxicities than patients receiving bevacizumab and chemotherapy alone. The incidences of any Common Terminology Criteria for Adverse Events grade 3 and 4 adverse events (AEs) were 87% and 72% in the panitumumab and control groups, respectively. Grade 3 and 4 AEs occurring more commonly in panitumumab-treated patients included rash/acneiform dermatitis, diarrhea, dehydration, primarily resulting from diarrhea, hypokalemia, stomatitis/mucositis, and pulmonary embolism. The addition of panitumumab to bevacizumab and chemotherapy for the first-line treatment of metastatic colorectal cancer was harmful when compared with bevacizumab and chemotherapy alone. The use of panitumumab in this setting cannot be recommended. JF - The oncologist AU - Giusti, Ruthann M AU - Cohen, Martin H AU - Keegan, Patricia AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA. ruthann.giusti@fda.hhs.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 284 EP - 290 VL - 14 IS - 3 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Organoplatinum Compounds KW - oxaliplatin KW - 04ZR38536J KW - irinotecan KW - 0H43101T0J KW - Bevacizumab KW - 2S9ZZM9Q9V KW - panitumumab KW - 6A901E312A KW - Fluorouracil KW - U3P01618RT KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - United States KW - Disease-Free Survival KW - Organoplatinum Compounds -- administration & dosage KW - Humans KW - Camptothecin -- adverse effects KW - Camptothecin -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- adverse effects KW - United States Food and Drug Administration KW - Organoplatinum Compounds -- adverse effects KW - Drug Approval KW - Treatment Outcome KW - Neoplasm Metastasis KW - Camptothecin -- analogs & derivatives KW - Middle Aged KW - Female KW - Male KW - Colorectal Neoplasms -- pathology KW - Antibodies, Monoclonal -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Colorectal Neoplasms -- drug therapy KW - Antibodies, Monoclonal -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67085788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+review+of+a+panitumumab+%28Vectibix%29+clinical+trial+for+first-line+treatment+of+metastatic+colorectal+cancer.&rft.au=Giusti%2C+Ruthann+M%3BCohen%2C+Martin+H%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Giusti&rft.aufirst=Ruthann&rft.date=2009-03-01&rft.volume=14&rft.issue=3&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2008-0254 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2009-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2008-0254 ER - TY - JOUR T1 - Five-year experience of human papillomavirus DNA and Papanicolaou test cotesting. AN - 67047912; 19300322 AB - To estimate the 5-year age group-specific test positives for Pap tests and human papillomavirus (HPV) testing in a large, general screening population of women 30 and older. Using data from Kaiser Permanente Northern California, a large health maintenance organization that introduced cotesting in 2003, we evaluated the cotesting results overall and by 5-year age groups. Women (n=580,289) who opted for and underwent cotesting (n cotests=812,598) between January 2003 and April 2008 were included in the analysis. Pap tests interpreted as atypical squamous cells of undetermined significance (ASC-US) or more severe were considered to be positive. Women were tested for carcinogenic HPV using an assay approved by the U.S. Food and Drug Administration. Binomial exact 95% confidence intervals (CIs) were calculated. Overall, 6.27% (95% CI 6.21-6.32%) of cotests were carcinogenic HPV positive, and only 3.99% (95% CI 3.94-4.03%) cotests had normal cytology and were carcinogenic HPV positive. By comparison, 5.18% (95% CI 5.13-5.23%) of cotests had ASC-US or more severe cytology, and 2.87% (95% CI 2.84-2.91%) of cotests had ASC-US or more severe cytology and were carcinogenic HPV negative. In a general screening population, concerns about excessive HPV test positives among women aged 30 years and older are not borne out. JF - Obstetrics and gynecology AU - Castle, Philip E AU - Fetterman, Barbara AU - Poitras, Nancy AU - Lorey, Thomas AU - Shaber, Ruth AU - Kinney, Walter AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 595 EP - 600 VL - 113 IS - 3 SN - 0029-7844, 0029-7844 KW - DNA, Viral KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - DNA, Viral -- analysis KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Papillomaviridae -- genetics KW - Middle Aged KW - Female KW - Comorbidity KW - Papillomavirus Infections -- epidemiology KW - Papillomavirus Infections -- diagnosis KW - Uterine Cervical Neoplasms -- epidemiology KW - Uterine Cervical Neoplasms -- diagnosis KW - Mass Screening -- methods KW - Vaginal Smears -- methods KW - Uterine Cervical Neoplasms -- virology KW - Papanicolaou Test UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67047912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Five-year+experience+of+human+papillomavirus+DNA+and+Papanicolaou+test+cotesting.&rft.au=Castle%2C+Philip+E%3BFetterman%2C+Barbara%3BPoitras%2C+Nancy%3BLorey%2C+Thomas%3BShaber%2C+Ruth%3BKinney%2C+Walter&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2009-03-01&rft.volume=113&rft.issue=3&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/10.1097%2FAOG.0b013e3181996ffa LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-14 N1 - Date created - 2009-03-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2002 Apr 24;287(16):2120-9 [11966387] Lancet Oncol. 2008 Oct;9(10):937-45 [18783988] CA Cancer J Clin. 2002 Nov-Dec;52(6):342-62 [12469763] J Natl Cancer Inst. 2003 Jan 1;95(1):46-52 [12509400] Am J Obstet Gynecol. 2003 Jun;188(6):1383-92 [12824967] Am J Obstet Gynecol. 2003 Jun;188(6):1393-400 [12824968] N Engl J Med. 2003 Oct 16;349(16):1501-9 [14561792] Obstet Gynecol. 2004 Feb;103(2):304-9 [14754700] Am J Clin Pathol. 2004 Aug;122(2):238-45 [15323141] JAMA. 1994 Jun 15;271(23):1866-9 [8196145] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Am J Clin Pathol. 2005 Nov;124(5):716-21 [16203283] Lancet. 2006 Feb 11;367(9509):489-98 [16473126] Int J Cancer. 2006 Sep 1;119(5):1095-101 [16586444] Vaccine. 2006 Aug 31;24 Suppl 3:S3/63-70 [16950019] Vaccine. 2006 Aug 31;24 Suppl 3:S3/78-89 [16950021] Cancer Res. 2006 Nov 1;66(21):10630-6 [17062559] JAMA. 2007 Feb 28;297(8):813-9 [17327523] Obstet Gynecol. 2007 Jun;109(6):1325-31 [17540804] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] Am J Obstet Gynecol. 2007 Oct;197(4):356.e1-6 [17904958] N Engl J Med. 2007 Oct 18;357(16):1579-88 [17942871] N Engl J Med. 2007 Oct 18;357(16):1589-97 [17942872] Lancet. 2007 Nov 24;370(9601):1764-72 [17919718] Obstet Gynecol. 2008 Jan;111(1):2-3 [18165385] Obstet Gynecol. 2008 Jan;111(1):167-77 [18165406] Ann Intern Med. 2008 Apr 1;148(7):493-500 [18378945] Ann Intern Med. 2008 Apr 1;148(7):557-9 [18378951] Am J Epidemiol. 2008 Jul 15;168(2):138-44; discussion 145-8 [18483124] Arch Pathol Lab Med. 2008 Aug;132(8):1290-4 [18684028] BMJ. 2008;337:a1284 [18801868] BMJ. 2008;337:a1343 [18801869] Virus Res. 2002 Nov;89(2):263-9 [12445665] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/AOG.0b013e3181996ffa ER - TY - JOUR T1 - A revised conversion factor relating respirable dust concentrations measured by 10 mm Dorr-Oliver nylon cyclones operated at 1.7 and 2.0 L min(-1). AN - 67021041; 19280048 AB - Accurate measurement of workplace respirable dust concentration is an essential step in eliminating lung disease in any occupational setting. In the United States (U.S.) coal mining industry, this measurement process has relied upon a personal sampler that includes a 10 mm Dorr-Oliver (DO) nylon cyclone operated at a flow rate of 2.0 L min(-1) to collect a respirable dust sample. Dust concentrations measured with this sampler are multiplied by 1.38, which was empirically derived, to convert them to measurements approximating the United Kingdom British Medical Research Council (BMRC) definition of respirable dust upon which the health effects of coal mine dust are based. The International Organization for Standardization (ISO) subsequently refined the respirable dust definition and the U.S. National Institute for Occupational Safety and Health (NIOSH) 1995 Criteria for a Recommended Standard presented a conversion multiplier of 0.857 to apply to the 2.0 L min(-1) DO (in addition to the1.38 multiplier) to obtain equivalent ISO concentrations, as approximated by the 1.7 L min(-1) DO. However, the conversion multiplier 0.857 was derived indirectly from a limited size distribution data set rather than a direct comparison of the DO samplers. The present analysis focuses on providing a more accurate conversion multiplier derived from direct comparisons of the 2.0 L min(-1) (with 1.38 BMRC equivalency multiplier) and 1.7 L min(-1) DO cyclones. A weighted linear regression analysis of this database suggests that a more accurate estimate of the conversion multiplier is 0.815. JF - Journal of environmental monitoring : JEM AU - Page, Steven J AU - Volkwein, Jon C AD - US Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 684 EP - 689 VL - 11 IS - 3 KW - Air Pollutants KW - 0 KW - Coal KW - Index Medicus KW - Occupational Exposure KW - Particle Size KW - Mining KW - Environmental Exposure -- prevention & control KW - Environmental Monitoring -- methods KW - Air Pollutants -- chemistry KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67021041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=A+revised+conversion+factor+relating+respirable+dust+concentrations+measured+by+10+mm+Dorr-Oliver+nylon+cyclones+operated+at+1.7+and+2.0+L+min%28-1%29.&rft.au=Page%2C+Steven+J%3BVolkwein%2C+Jon+C&rft.aulast=Page&rft.aufirst=Steven&rft.date=2009-03-01&rft.volume=11&rft.issue=3&rft.spage=684&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=1464-0333&rft_id=info:doi/10.1039%2Fb817922k LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-24 N1 - Date created - 2009-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/b817922k ER - TY - JOUR T1 - Issues in the development of epidemiologic studies of workers exposed to engineered nanoparticles. AN - 67011515; 19225418 AB - Capitalizing on phenomena at the nanoscale may present great benefits to society. Nevertheless, until the hazards and risks of engineered nanoparticles are determined, the technological products and advances of nanotechnology may be impeded by the societal concerns. Although animal data provide the necessary first step in hazard and risk assessment, ultimately epidemiological studies will be required, especially studies of workers exposed to engineered nanoparticles. It may be too soon to conduct informative epidemiological studies but it is now appropriate to identify issues that will be pertinent and prepare strategies to address them. The published scientific literature on incidental and engineered nanoparticles and air pollution were reviewed to identify issues in the conduct of epidemiological studies of workers exposed to engineered nanoparticles. Twelve important issues were identified-the most critical pertaining to particle heterogeneity, temporal factors, exposure characterization, disease endpoints, and identification of the study population. Consideration of these issues provides the foundation for initiating epidemiologic research on workers exposed to engineered nanoparticles. JF - Journal of occupational and environmental medicine AU - Schulte, Paul A AU - Schubauer-Berigan, Mary K AU - Mayweather, Candis AU - Geraci, Charles L AU - Zumwalde, Ralph AU - McKernan, John L AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. PSchulte@cdc.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 323 EP - 335 VL - 51 IS - 3 KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - Humans KW - Industry KW - Occupational Exposure KW - Epidemiologic Studies KW - Program Development KW - Research Design KW - Nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67011515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Issues+in+the+development+of+epidemiologic+studies+of+workers+exposed+to+engineered+nanoparticles.&rft.au=Schulte%2C+Paul+A%3BSchubauer-Berigan%2C+Mary+K%3BMayweather%2C+Candis%3BGeraci%2C+Charles+L%3BZumwalde%2C+Ralph%3BMcKernan%2C+John+L&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2009-03-01&rft.volume=51&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=1536-5948&rft_id=info:doi/10.1097%2FJOM.0b013e3181990c2c LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-13 N1 - Date created - 2009-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JOM.0b013e3181990c2c ER - TY - JOUR T1 - Steam sterilization and internal count sheets: assessing the potential for cytotoxicity. AN - 67001412; 19269377 AB - Count sheets, when placed in contact with surgical instruments during steam sterilization, can transfer ink to the instruments. To explore whether this poses a safety concern, stainless steel instruments were placed on top of completely inked paper and subjected to steam sterilization, extracted, and tested for cytotoxicity. Preprinted labels were examined in a similar fashion. Extracts from stainless steel devices exposed to ink, toner, or labels showed no significant cytotoxic response, although the ink residue on the devices after steam sterilization is difficult to remove and detrimental to the instrument. Placing a barrier between the count sheet and the devices facilitates reuse of the instruments. Copyright (c) AORN, Inc, 2009. JF - AORN journal AU - Lucas, Anne D AU - Chobin, Nancy AU - Conner, Ramona AU - Gordon, Edward A AU - Mitchell, Sheila AU - Perry, Ben AU - Stratmeyer, Mel E AD - US Food and Drug Administration Center for Device and Radiological Health, Silver Spring, MD, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 521 EP - 2, 525-31 VL - 89 IS - 3 SN - 0001-2092, 0001-2092 KW - Stainless Steel KW - 12597-68-1 KW - Index Medicus KW - Nursing KW - Product Labeling KW - Humans KW - Toxicity Tests KW - Ink KW - Equipment Contamination -- prevention & control KW - Surgical Instruments KW - Sterilization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67001412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AORN+journal&rft.atitle=Steam+sterilization+and+internal+count+sheets%3A+assessing+the+potential+for+cytotoxicity.&rft.au=Lucas%2C+Anne+D%3BChobin%2C+Nancy%3BConner%2C+Ramona%3BGordon%2C+Edward+A%3BMitchell%2C+Sheila%3BPerry%2C+Ben%3BStratmeyer%2C+Mel+E&rft.aulast=Lucas&rft.aufirst=Anne&rft.date=2009-03-01&rft.volume=89&rft.issue=3&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=AORN+journal&rft.issn=00012092&rft_id=info:doi/10.1016%2Fj.aorn.2008.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-02 N1 - Date created - 2009-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.aorn.2008.09.001 ER - TY - JOUR T1 - Comparison of nanoparticle filtration performance of NIOSH-approved and CE-marked particulate filtering facepiece respirators. AN - 66992092; 19261695 AB - The National Institute for Occupational Safety and Health (NIOSH) and European Norms (ENs) employ different test protocols for evaluation of air-purifying particulate respirators commonly referred to as filtering facepiece respirators (FFR). The relative performance of the NIOSH-approved and EN-certified 'Conformité Européen' (CE)-marked FFR is not well studied. NIOSH requires a minimum of 95 and 99.97% efficiencies for N95 and P100 FFR, respectively; meanwhile, the EN requires 94 and 99% efficiencies for FFRs, class P2 (FFP2) and class P3 (FFP3), respectively. To better understand the filtration performance of NIOSH- and CE-marked FFRs, initial penetration levels of N95, P100, FFP2 and FFP3 respirators were measured using a series of polydisperse and monodisperse aerosol test methods and compared. Initial penetration levels of polydisperse NaCl aerosols [mass median diameter (MMD) of 238 nm] were measured using a method similar to the NIOSH respirator certification test method. Monodisperse aerosol penetrations were measured using silver particles for 4-30 nm and NaCl particles for 20-400 nm ranges. Two models for each FFR type were selected and five samples from each model were tested against charge neutralized aerosol particles at 85 l min(-1) flow rate. Penetrations from the 238 nm MMD polydisperse aerosol test were <1% for N95 and FFP2 models and <0.03% for P100 and FFP3 models. Monodisperse aerosol penetration levels showed that the most penetrating particle size (MPPS) was in the 30-60 nm range for all models of FFRs tested in the study. Percentage penetrations at the MPPS were <4.28, <2.22, <0.009 and <0.164 for the N95, FFP2, P100 and FFP3 respirator models, respectively. The MPPS obtained for all four FFR types suggested particle capturing by electrostatic mechanism. Liquid isopropanol treatment of FFRs shifted the MPPS to 200-300 nm and dramatically increased polydisperse as well as monodisperse aerosol penetrations of all four FFR types indicating that all the four FFR types share filtration characteristics of electret filters. Electrostatic charge removal from all four FFR types also increased penetration levels of 400-1000 nm range particles. Particle penetration data obtained in this study showed that the eight models of NIOSH-approved N95 and P100 and CE-marked FFP2 and FFP3 respirators used in this study provided expected levels of laboratory filtration performance against nanoparticles. JF - The Annals of occupational hygiene AU - Rengasamy, Samy AU - Eimer, Benjamin C AU - Shaffer, Ronald E AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, 626 Cochrans Mill Road, PO Box 18070, Pittsburgh, PA 15236, USA. arengasamy@cdc.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 117 EP - 128 VL - 53 IS - 2 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - United States KW - Equipment Design KW - Humans KW - Filtration -- instrumentation KW - National Institute for Occupational Safety and Health (U.S.) -- standards KW - Europe KW - Nanoparticles KW - Occupational Health KW - Respiratory Protective Devices -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66992092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Comparison+of+nanoparticle+filtration+performance+of+NIOSH-approved+and+CE-marked+particulate+filtering+facepiece+respirators.&rft.au=Rengasamy%2C+Samy%3BEimer%2C+Benjamin+C%3BShaffer%2C+Ronald+E&rft.aulast=Rengasamy&rft.aufirst=Samy&rft.date=2009-03-01&rft.volume=53&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmen086 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-01 N1 - Date created - 2009-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/men086 ER - TY - JOUR T1 - Characteristics of children whose siblings have fetal alcohol syndrome or incomplete fetal alcohol syndrome. AN - 66991586; 19254987 AB - To describe the clinical features of American Indian children born just before and just after a sibling with fetal alcohol syndrome or incomplete fetal alcohol syndrome. Two retrospective case-control studies were conducted of Northern Plains American Indian children with fetal alcohol syndrome or incomplete fetal alcohol syndrome identified from 1981 to 1993 by using International Classification of Diseases, Ninth Revision, Clinical Modification code 760.71. Compared with the controls, the 39 siblings born just before children with fetal alcohol syndrome (study 1) and 30 siblings born just before children with incomplete fetal alcohol syndrome (study 2) had more facial dysmorphology (23.1% and 16.7%, respectively), growth delay (38.5% and 10.0%), and central nervous system impairment (48.7% and 33.3%). The 20 siblings born just after children with fetal alcohol syndrome (study 1) and 22 siblings born just after children with incomplete fetal alcohol syndrome (study 2) had more facial dysmorphology (20.0% and 9.1%, respectively), growth delay (45.0% and 22.7%), and central nervous system impairment (50.0% and 31.8%) than the control siblings. The "before" siblings had characteristics of fetal alcohol syndrome that could have predicted that the next child was at risk for fetal alcohol syndrome. The "after" siblings had better outcomes than the previous siblings with fetal alcohol syndrome, a finding that was associated with a decrease in maternal alcohol consumption during the after-sibling pregnancy. JF - Pediatrics AU - Kvigne, Valborg L AU - Leonardson, Gary R AU - Borzelleca, Joseph AU - Neff-Smith, Martha AU - Welty, Thomas K AD - Aberdeen Area Indian Health Service, Aberdeen, South Dakota, USA. kvig6@aol.com Y1 - 2009/03// PY - 2009 DA - March 2009 SP - e526 EP - e533 VL - 123 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Retrospective Studies KW - Craniofacial Abnormalities -- epidemiology KW - Child KW - Craniofacial Abnormalities -- diagnosis KW - Pregnancy KW - Cross-Sectional Studies KW - Foster Home Care -- statistics & numerical data KW - Developmental Disabilities -- diagnosis KW - Risk Factors KW - Case-Control Studies KW - Developmental Disabilities -- epidemiology KW - Child Behavior Disorders -- diagnosis KW - Hospitalization -- statistics & numerical data KW - Male KW - Child Behavior Disorders -- epidemiology KW - Female KW - Siblings KW - Indians, North American -- statistics & numerical data KW - Fetal Alcohol Spectrum Disorders -- epidemiology KW - Fetal Alcohol Spectrum Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66991586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Characteristics+of+children+whose+siblings+have+fetal+alcohol+syndrome+or+incomplete+fetal+alcohol+syndrome.&rft.au=Kvigne%2C+Valborg+L%3BLeonardson%2C+Gary+R%3BBorzelleca%2C+Joseph%3BNeff-Smith%2C+Martha%3BWelty%2C+Thomas+K&rft.aulast=Kvigne&rft.aufirst=Valborg&rft.date=2009-03-01&rft.volume=123&rft.issue=3&rft.spage=e526&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2008-2423 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-30 N1 - Date created - 2009-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.2008-2423 ER - TY - JOUR T1 - Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles. AN - 66985401; 19129473 AB - We developed a europium nanoparticle-based immunoassay (ENIA) for the sensitive detection of anthrax protective antigen (PA). The ENIA exhibited a linear dose-dependent pattern within the detection range of 0.01 to 100 ng/ml and was approximately 100-fold more sensitive than enzyme-linked immunosorbent assay (ELISA). False-positive results were not observed with serum samples from healthy adults, mouse plasma without PA, or plasma samples collected from mice injected with anthrax lethal factor or edema factor alone. For the detection of plasma samples spiked with PA, the detection sensitivities for ENIA and ELISA were 100% (11/11 samples) and 36.4% (4/11 samples), respectively. The assay exhibited a linear but qualitative correlation between the PA injected and the PA detected in murine blood (r=0.97731; P<0.0001). Anthrax PA was also detected in the circulation of mice infected with spores from a toxigenic Sterne-like strain of Bacillus anthracis, but only in the later stages of infection. These results indicate that the universal labeling technology based on europium nanoparticles and its application may provide a rapid and sensitive testing platform for clinical diagnosis and laboratory research. JF - Clinical and vaccine immunology : CVI AU - Tang, Shixing AU - Moayeri, Mahtab AU - Chen, Zhaochun AU - Harma, Harri AU - Zhao, Jiangqin AU - Hu, Haijing AU - Purcell, Robert H AU - Leppla, Stephen H AU - Hewlett, Indira K AD - Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. Shixing.tang@fda.hhs.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 408 EP - 413 VL - 16 IS - 3 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - anthrax toxin KW - Europium KW - 444W947O8O KW - Index Medicus KW - Sensitivity and Specificity KW - Young Adult KW - Animals KW - Immunoassay -- methods KW - Humans KW - Adult KW - Mice KW - False Positive Reactions KW - Anthrax -- diagnosis KW - Europium -- metabolism KW - Bacterial Toxins -- analysis KW - Antigens, Bacterial -- analysis KW - Nanoparticles -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66985401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+vaccine+immunology+%3A+CVI&rft.atitle=Detection+of+anthrax+toxin+by+an+ultrasensitive+immunoassay+using+europium+nanoparticles.&rft.au=Tang%2C+Shixing%3BMoayeri%2C+Mahtab%3BChen%2C+Zhaochun%3BHarma%2C+Harri%3BZhao%2C+Jiangqin%3BHu%2C+Haijing%3BPurcell%2C+Robert+H%3BLeppla%2C+Stephen+H%3BHewlett%2C+Indira+K&rft.aulast=Tang&rft.aufirst=Shixing&rft.date=2009-03-01&rft.volume=16&rft.issue=3&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=Clinical+and+vaccine+immunology+%3A+CVI&rft.issn=1556-679X&rft_id=info:doi/10.1128%2FCVI.00412-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-13 N1 - Date created - 2009-03-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Protein Expr Purif. 2000 Apr;18(3):293-302 [10733882] J Acquir Immune Defic Syndr. 2007 Oct 1;46(2):231-7 [17693896] Clin Chem. 2001 Mar;47(3):561-8 [11238312] Clin Chem. 2001;47(7):1269-78 [11427459] Emerg Infect Dis. 2001 Nov-Dec;7(6):933-44 [11747719] Emerg Infect Dis. 2002 Oct;8(10):1103-10 [12396924] Clin Chim Acta. 2003 Feb;328(1-2):45-58 [12559598] J Cell Biol. 2003 Feb 3;160(3):321-8 [12551953] J Biol Chem. 2003 Feb 14;278(7):5227-34 [12468536] Science. 2003 Sep 26;301(5641):1884-6 [14512622] Clin Diagn Lab Immunol. 2004 Jan;11(1):50-5 [14715544] Curr Opin Microbiol. 2004 Feb;7(1):19-24 [15036135] J Am Chem Soc. 2004 May 19;126(19):5932-3 [15137735] Anal Biochem. 1984 Mar;137(2):335-43 [6375455] Infect Immun. 1988 Jul;56(7):1807-13 [3384478] Microbiology. 1996 Mar;142 ( Pt 3):707-15 [8868446] Mol Med. 1998 Feb;4(2):87-95 [9508786] Infect Immun. 1999 Apr;67(4):1860-5 [10085028] J Immunol Methods. 2004 Nov;294(1-2):111-22 [15604021] Chem Rev. 2005 Apr;105(4):1547-62 [15826019] Infect Immun. 2005 Sep;73(9):5978-87 [16113318] Infect Immun. 2005 Dec;73(12):8362-8 [16299334] Infect Immun. 2006 Jan;74(1):682-93 [16369025] J Infect Dis. 2006 Mar 1;193(5):625-33 [16453257] Clin Vaccine Immunol. 2006 May;13(5):541-6 [16682473] Clin Vaccine Immunol. 2006 Jun;13(6):671-7 [16760326] Cell Microbiol. 2006 Oct;8(10):1634-42 [16984418] Biochem J. 2007 Mar 15;402(3):405-17 [17313374] Infect Immun. 2007 Nov;75(11):5175-84 [17724066] Luminescence. 2000 Nov-Dec;15(6):351-5 [11114110] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/CVI.00412-08 ER - TY - JOUR T1 - Interference of cell cycle progression by zidovudine and lamivudine in NIH 3T3 cells. AN - 66982125; 18936108 AB - Zidovudine (3'-azido-3'-deoxythymidine; AZT) and lamivudine [(-)2',3'-dideoxy-3'-thiacytidine; 3TC] are nucleoside reverse transcriptase inhibitors used to treat and prevent human immunodeficiency virus-1 infections. In short-term incubations (<48 h), AZT, but not 3TC, has been shown to interfere with cell cycle progression. In the present study, we examined if these alterations persist during long-term incubations in which cells were exposed to AZT (0-1000 microM) or 3TC (0-500 microM) in continuous culture for up to 5 weeks. In addition, we investigated the reversibility of these effects upon removal of the drugs. Both drugs caused concentration- and time-dependent decreases in the number of viable cells, with the effect being more pronounced with AZT. There was only a slight increase in the number of viable cells treated with AZT for 5 weeks and then allowed a 1-week recovery period; cell viability in cells treated with 3TC returned to control levels during the recovery period. The decrease in viable cells was not due to apoptotic or necrotic cell death, but rather was associated with S and G2/M phase cell cycle arrest. Western blot analysis indicated that AZT treatment caused a decrease in checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) at all time points. Cyclin-dependent kinase 1 was decreased at later time points, while cyclin A was increased at early times. These data indicate that AZT and, to a lesser extent, 3TC interfere with cell growth by slowing cell cycle progression and that checkpoint proteins Chk1 and Chk2 may play an important role in this delay. JF - Mutagenesis AU - Fang, Jia-Long AU - McGarrity, Lynda J AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. jia-long.fang@fda.hhs.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 133 EP - 141 VL - 24 IS - 2 KW - Cell Cycle Proteins KW - 0 KW - Lamivudine KW - 2T8Q726O95 KW - Zidovudine KW - 4B9XT59T7S KW - DNA KW - 9007-49-2 KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Necrosis KW - Blotting, Western KW - Cell Survival -- drug effects KW - DNA -- metabolism KW - Mice KW - Flow Cytometry KW - Cell Death -- drug effects KW - NIH 3T3 Cells KW - Cell Cycle Proteins -- metabolism KW - Bromodeoxyuridine -- metabolism KW - Zidovudine -- pharmacology KW - Lamivudine -- chemistry KW - Lamivudine -- pharmacology KW - Zidovudine -- chemistry KW - Cell Cycle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66982125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Interference+of+cell+cycle+progression+by+zidovudine+and+lamivudine+in+NIH+3T3+cells.&rft.au=Fang%2C+Jia-Long%3BMcGarrity%2C+Lynda+J%3BBeland%2C+Frederick+A&rft.aulast=Fang&rft.aufirst=Jia-Long&rft.date=2009-03-01&rft.volume=24&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgen059 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-19 N1 - Date created - 2009-03-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 1989 Jul;36(1):9-14 [2747633] J Biol Chem. 1987 Feb 15;262(5):2187-9 [2434477] J Biol Chem. 1990 Jul 15;265(20):11914-8 [1694849] Cancer Commun. 1990;2(1):55-62 [2369551] Antimicrob Agents Chemother. 1990 Jun;34(6):1237-43 [2118327] Clin Lab Haematol. 1990;12(2):177-84 [2208948] J Biol Chem. 1992 Jan 15;267(2):848-54 [1730673] Int J Radiat Oncol Biol Phys. 1992;22(4):813-5 [1544855] Mutat Res. 1994 Apr;321(1-2):113-8 [7510839] Cancer Res. 1994 Dec 1;54(23):6235-42 [7954472] Clin Mater. 1994;16(4):189-94 [10150166] Nat Med. 1995 May;1(5):417-22 [7585087] Antiviral Res. 1995 May;27(1-2):1-17 [7486948] AIDS. 1995 Dec;9(12):1323-9 [8605051] Mutat Res. 1996 Jul 5;368(3-4):301-7 [8692236] Fundam Appl Toxicol. 1996 Aug;32(2):148-58 [8921318] Science. 1997 Sep 5;277(5331):1497-501 [9278511] J Natl Cancer Inst. 1997 Nov 5;89(21):1602-8 [9362158] Mol Carcinog. 1998 Sep;23(1):45-51 [9766437] Science. 1998 Dec 4;282(5395):1893-7 [9836640] Nucleosides Nucleotides Nucleic Acids. 2004;23(11):1797-811 [15598079] Mutagenesis. 2005 Mar;20(2):139-46 [15784690] Antivir Ther. 2005;10(5):615-24 [16152755] Mutat Res. 2006 Jan 29;593(1-2):97-107 [16165166] Antimicrob Agents Chemother. 2007 Feb;51(2):583-90 [17158934] Environ Mol Mutagen. 2007 Apr-May;48(3-4):224-38 [17358033] N Engl J Med. 1987 Jul 23;317(4):192-7 [3299090] J Acquir Immune Defic Syndr. 1999 Dec 15;22(5):477-83 [10961609] Clin Ther. 2000 Aug;22(8):911-36; discussion 898 [10972629] IARC Monogr Eval Carcinog Risks Hum. 2000;76:45-173 [11000975] Lancet. 2000 Oct 21;356(9239):1423-30 [11052597] J Antimicrob Chemother. 2000 Nov;46(5):657-68 [11062184] J Acquir Immune Defic Syndr. 2002 Apr 1;29(4):323-9 [11917235] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7 [2430286] Ann Intern Med. 1990 May 15;112(10):727-37 [1970466] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/mutage/gen059 ER - TY - JOUR T1 - Polychlorinated biphenyls and risk of testicular germ cell tumors. AN - 66978883; 19223531 AB - Exposure to endocrine-disrupting chemicals, such as polychlorinated biphenyls (PCB), may alter hormonal balance and thereby increase risk of testicular germ cell tumors (TGCT). To study the relationship of PCBs to TGCT, prediagnostic serum samples from 736 cases and 913 controls in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants study were analyzed. Adjusted odds ratios and 95% confidence intervals were estimated using logistic regression. PCB levels were examined in association with all TGCT and, separately, with each histologic type (seminoma and nonseminoma). Risks associated with seven functional groupings of PCBs, as well as sum of PCBs, were also examined. There were significantly decreased risks of TGCT in association with eight PCBs (PCB-118, PCB-138, PCB-153, PCB-156, PCB-163, PCB-170, PCB-180, and PCB-187) and no association with the remaining three (PCB-99, PCB-101, and PCB-183). The same eight congeners were significantly associated with decreased risk of nonseminoma, whereas five (PCB-138, PCB-153, PCB-156, PCB-163, and PCB-170) were associated with decreased risk of seminoma. All functional groupings of PCBs were also associated with decreased risk of TGCT and of nonseminoma, whereas six of the seven functional groups were associated with decreased risk of seminoma. Sum of PCBs was significantly associated with decreased risk of TGCT (P(trend) = 0.006), nonseminoma (P(trend) = 0.007), and seminoma (P(trend) = 0.05). Overall, these data do not support the hypothesis that PCB exposure increases the risk of TGCT. JF - Cancer research AU - McGlynn, Katherine A AU - Quraishi, Sabah M AU - Graubard, Barry I AU - Weber, Jean-Philippe AU - Rubertone, Mark V AU - Erickson, Ralph L AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA. mcglynnk@mail.nih.gov Y1 - 2009/03/01/ PY - 2009 DA - 2009 Mar 01 SP - 1901 EP - 1909 VL - 69 IS - 5 KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Risk KW - Hypospadias -- chemically induced KW - Age Factors KW - Humans KW - Adult KW - Middle Aged KW - Dichlorodiphenyl Dichloroethylene -- toxicity KW - Adolescent KW - Male KW - Polychlorinated Biphenyls -- toxicity KW - Testicular Neoplasms -- chemically induced KW - Neoplasms, Germ Cell and Embryonal -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66978883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Polychlorinated+biphenyls+and+risk+of+testicular+germ+cell+tumors.&rft.au=McGlynn%2C+Katherine+A%3BQuraishi%2C+Sabah+M%3BGraubard%2C+Barry+I%3BWeber%2C+Jean-Philippe%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2009-03-01&rft.volume=69&rft.issue=5&rft.spage=1901&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-3935 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-20 N1 - Date created - 2009-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Horm Res. 1999 Dec;51(6):261-9 [10640886] World J Urol. 2004 Apr;22(1):2-14 [15034740] Hum Reprod. 2001 May;16(5):972-8 [11331648] Cancer Invest. 2001;19(8):842-53 [11768038] Eur J Endocrinol. 2002 Mar;146(3):357-63 [11888842] Hum Reprod. 2002 Aug;17(8):1973-9 [12151423] Am J Public Health. 2002 Dec;92(12):1900-4 [12453804] Fertil Steril. 2002 Dec;78(6):1187-94 [12477510] Cancer. 2003 Jan 1;97(1):63-70 [12491506] Environ Health Perspect. 2003 Apr;111(4):409-13 [12676591] APMIS. 2003 Jan;111(1):267-78; discussion 278-9 [12752272] Environ Health Perspect. 2003 Jun;111(7):930-4 [12782494] Environ Health Perspect. 2003 Sep;111(12):1505-11 [12948891] Arch Toxicol. 2004 May;78(5):252-68 [15064922] Hum Reprod. 2004 Sep;19(9):2066-75 [15284211] Nature. 1969 Oct 18;224(5216):247-50 [5388040] Arch Environ Contam Toxicol. 1986 Jul;15(4):333-41 [3090950] Int J Androl. 1987 Feb;10(1):19-28 [3034791] IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;6:1-729 [3504843] Environ Health Perspect. 1989 May;81:225-39 [2503374] Zentralbl Gynakol. 1990;112(13):817-21 [1700563] Nature. 1995 Jun 15;375(6532):581-5 [7791873] Int J Cancer. 1996 Mar 15;65(6):723-9 [8631581] Environ Health Perspect. 1996 Aug;104 Suppl 4:741-803 [8880001] Environ Health Perspect. 1997 Jan;105(1):13-4 [9074863] Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2224-36 [16172236] Pharmacogenet Genomics. 2006 May;16(5):375-7 [16609370] Nat Clin Pract Urol. 2006 Oct;3(10):532-43 [17031378] J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):184-6 [17049842] J Assist Reprod Genet. 2006 Sep-Oct;23(9-10):393-9 [17019632] Environ Health Perspect. 2007 Oct;115(10):1490-6 [17938741] Environ Health Perspect. 2008 Mar;116(3):269-77 [18335090] J Natl Cancer Inst. 2008 May 7;100(9):663-71 [18445826] Arch Environ Contam Toxicol. 2008 Jul;55(1):143-52 [18166985] Eur J Pediatr Surg. 2000 Oct;10(5):304-9 [11194541] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-3935 ER - TY - JOUR T1 - Quantitative evaluation of pharmacokinetic inhibition of CYP3A substrates by ketoconazole: a simulation study. AN - 66975000; 19246732 AB - The US Food and Drug Administration draft drug interaction guidance recommends that 400 mg ketoconazole (KTZ) be administered once daily for several days (QD400) for maximal CYP3A inhibition. Some investigators suggest that a single dose of 400 mg (SD400) KTZ is sufficient given its short half-life (t(1/2) approximately 3-5 hr). To determine the impact of KTZ regimens on CYP3A inhibition, we simulated AUC fold-change (AUCR) in the presence of SD400, QD400, or 200 mg twice-daily (BID200) KTZ for theoretical CYP3A substrates. Ratios of AUCR (AUCR(QD400)/AUCR(SD400) and AUCR(BID200) AUCR(QD400)) increase with increasing bioavailability and increasing substrate t(1/2). The SD400 KTZ regimen may provide maximal inhibition only for a subset of substrates (ie, low bioavailability and short t(1/2)). For substrates with t(1/2) longer than that of KTZ, multiple KTZ dosing is critical and BID200 appears to provide greater inhibition than QD400. Also, timing of KTZ administration should be optimized to allow maximal presystemic enzyme inhibition prior to substrate administration. JF - Journal of clinical pharmacology AU - Zhao, Ping AU - Ragueneau-Majlessi, Isabelle AU - Zhang, Lei AU - Strong, John M AU - Reynolds, Kellie S AU - Levy, Rene H AU - Thummel, Kenneth E AU - Huang, Shiew-Mei AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Room 3188, Building 51, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 351 EP - 359 VL - 49 IS - 3 SN - 0091-2700, 0091-2700 KW - Antifungal Agents KW - 0 KW - Cytochrome P-450 CYP3A Inhibitors KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Ketoconazole KW - R9400W927I KW - Index Medicus KW - Young Adult KW - Drug Administration Schedule KW - Drug Interactions KW - Area Under Curve KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Biological Availability KW - Half-Life KW - Cytochrome P-450 CYP3A -- metabolism KW - Adult KW - Cross-Over Studies KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Ketoconazole -- pharmacokinetics KW - Ketoconazole -- metabolism KW - Antifungal Agents -- pharmacokinetics KW - Antifungal Agents -- pharmacology KW - Antifungal Agents -- metabolism KW - Models, Biological KW - Ketoconazole -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66975000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Quantitative+evaluation+of+pharmacokinetic+inhibition+of+CYP3A+substrates+by+ketoconazole%3A+a+simulation+study.&rft.au=Zhao%2C+Ping%3BRagueneau-Majlessi%2C+Isabelle%3BZhang%2C+Lei%3BStrong%2C+John+M%3BReynolds%2C+Kellie+S%3BLevy%2C+Rene+H%3BThummel%2C+Kenneth+E%3BHuang%2C+Shiew-Mei&rft.aulast=Zhao&rft.aufirst=Ping&rft.date=2009-03-01&rft.volume=49&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270008331196 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-01 N1 - Date created - 2009-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0091270008331196 ER - TY - JOUR T1 - Emergency department visits attributed to selected analgesics, United States, 2004-2005. AN - 66960484; 19116955 AB - To estimate the rate of emergency department (ED) visits attributed to selected analgesic-containing medications. We used a nationally representative public health surveillance system to provide estimates of adverse events identified in EDs, and a national telephone survey to provide estimates of selected analgesic-containing medication usage in the US population, 2004-2005. Analysis was restricted to products containing acetaminophen, aspirin, ibuprofen, or naproxen. Types of adverse events and outcomes were compared. Estimated numbers and rates of ED visits were calculated by analgesic groupings and patient age groups. The estimated overall rate of ED visits attributed to analgesic-containing medications was 1.6 visits /100,000 users per week. The very old and very young had the highest rates; there were minimal differences in rates by patient gender. Acetaminophen was the attributed drug with the most estimated ED visits and generally had the highest rates of ED visits. The highest estimated rate for a specific product group was among subjects 18-64 years of age taking narcotic-acetaminophen products (8.9 ED visits /100,000 users per week). Overall, 12% of patients presenting to EDs with analgesic-attributed events were hospitalized. Rates of ED visits due to analgesics vary depending on the age of the patient and the product; most do not result in hospitalization. Although the rate of emergency visits is relatively low, because of the wide use of the analgesics, public health impact is considerable. (c) 2009 John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and drug safety AU - Willy, Mary AU - Kelly, Judith P AU - Nourjah, Parivash AU - Kaufman, David W AU - Budnitz, Daniel S AU - Staffa, Judy AD - Center for Drug Evaluation and Research, FDA, Silver Spring, MD, USA. mary.willy@fda.hhs.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 188 EP - 195 VL - 18 IS - 3 KW - Analgesics KW - 0 KW - Index Medicus KW - Age Factors KW - Humans KW - Infant, Newborn KW - Aged KW - Child KW - Child, Preschool KW - Infant KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Drug Utilization -- statistics & numerical data KW - Health Care Surveys KW - Emergency Service, Hospital -- statistics & numerical data KW - Hospitalization -- statistics & numerical data KW - Analgesics -- therapeutic use KW - Analgesics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66960484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Emergency+department+visits+attributed+to+selected+analgesics%2C+United+States%2C+2004-2005.&rft.au=Willy%2C+Mary%3BKelly%2C+Judith+P%3BNourjah%2C+Parivash%3BKaufman%2C+David+W%3BBudnitz%2C+Daniel+S%3BStaffa%2C+Judy&rft.aulast=Willy&rft.aufirst=Mary&rft.date=2009-03-01&rft.volume=18&rft.issue=3&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=1099-1557&rft_id=info:doi/10.1002%2Fpds.1691 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-27 N1 - Date created - 2009-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pds.1691 ER - TY - JOUR T1 - Improving blood-borne viral diagnosis; clinical audit of the uptake of dried blood spot testing offered by a substance misuse service. AN - 66954123; 19175879 AB - The diagnosis of blood-borne viral infection amongst drug injectors in Wales is limited by a poor uptake of diagnostic testing; recent research suggests that dried blood spot (DBS) sample collection, rather than venepuncture, may improve diagnostic rates. We carried out an audit of the uptake of DBS testing for hepatitis C, hepatitis B and HIV amongst drug injectors attending a substance misuse service (SMS) in the first year of DBS testing being routinely offered to clients (1 May 2007 to 30 April 2008) and compared the uptake to venepuncture testing of SMS clients in the previous year. Uptake of DBS testing for hepatitis C, hepatitis B and HIV was almost six times greater than the uptake of venepuncture testing amongst clients of the SMS in the previous year. The data are consistent with the hypothesis that DBS testing can increase the uptake of blood-borne viral testing amongst current and ex-drug injectors. We accept that part of the almost sixfold increase in diagnostic testing observed in the first year of DBS testing may be due to an increase in awareness amongst drug injectors of testing opportunities and a prioritization of testing by the SMS. Nonetheless the dramatic increase in uptake demonstrates that DBS testing is acceptable to drug injectors and should be subject to more rigorous trials to evaluate its potential impact on diagnosis. JF - Journal of viral hepatitis AU - Craine, N AU - Parry, J AU - O'Toole, J AU - D'Arcy, S AU - Lyons, M AD - National Public Health Service for Wales, Ysbyty Gwynedd, Bangor, Wales, UK. noel.craine@nphs.wales.nhs.uk Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 219 EP - 222 VL - 16 IS - 3 KW - Antibodies, Viral KW - 0 KW - Index Medicus KW - Humans KW - AIDS Serodiagnosis KW - Ambulatory Care Facilities -- statistics & numerical data KW - Hepatitis B -- blood KW - Hepatitis C -- virology KW - HIV Infections -- virology KW - Hepatitis C -- blood KW - Substance Abuse, Intravenous -- therapy KW - Hepatitis B -- virology KW - Substance Abuse, Intravenous -- prevention & control KW - Blood-Borne Pathogens -- isolation & purification KW - HIV Infections -- diagnosis KW - Hepatitis B -- diagnosis KW - Antibodies, Viral -- blood KW - Clinical Audit KW - Blood Specimen Collection -- methods KW - HIV Infections -- blood KW - Hepatitis C -- diagnosis KW - Substance Abuse, Intravenous -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66954123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+viral+hepatitis&rft.atitle=Improving+blood-borne+viral+diagnosis%3B+clinical+audit+of+the+uptake+of+dried+blood+spot+testing+offered+by+a+substance+misuse+service.&rft.au=Craine%2C+N%3BParry%2C+J%3BO%27Toole%2C+J%3BD%27Arcy%2C+S%3BLyons%2C+M&rft.aulast=Craine&rft.aufirst=N&rft.date=2009-03-01&rft.volume=16&rft.issue=3&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+viral+hepatitis&rft.issn=1365-2893&rft_id=info:doi/10.1111%2Fj.1365-2893.2008.01061.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-25 N1 - Date created - 2009-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2893.2008.01061.x ER - TY - JOUR T1 - Potential neurotoxicity of ketamine in the developing rat brain. AN - 66944051; 19126600 AB - Ketamine, an N-methyl-D-aspartate (NMDA) receptor ion channel blocker, is a widely used anesthetic recently reported to enhance neuronal death in developing rodents and nonhuman primates. This study evaluated dose-response and time-course effects of ketamine, levels of ketamine in plasma and brain, and the relationship between altered NMDA receptor expression and ketamine-induced neuronal cell death during development. Postnatal day 7 rats were administered 5, 10, or 20 mg/kg ketamine using single or multiple injections (subcutaneously) at 2-h intervals, and the potential neurotoxic effects were examined 6 h after the last injection. No significant neurotoxic effects were detected in layers II or III of the frontal cortex of rats administered one, three, or six injections of 5 or 10 mg/kg ketamine. However, in rats administered six injections of 20 mg/kg ketamine, a significant increase in the number of caspase-3- and Fluoro-Jade C-positive neuronal cells was observed in the frontal cortex. Electron microscopic observations showed typical nuclear condensation and fragmentation indicating enhanced apoptotic characteristics. Increased cell death was also apparent in other brain regions. In addition, apoptosis occurred after plasma and brain levels of ketamine had returned to baseline levels. In situ hybridization also showed a remarkable increase in mRNA signals for the NMDA NR1 subunit in the frontal cortex. These data demonstrate that ketamine administration results in a dose-related and exposure-time dependent increase in neuronal cell death during development. Ketamine-induced cell death appears to be apoptotic in nature and closely associated with enhanced NMDA receptor subunit mRNA expression. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Zou, Xiaoju AU - Patterson, Tucker A AU - Sadovova, Natalya AU - Twaddle, Nathan C AU - Doerge, Daniel R AU - Zhang, Xuan AU - Fu, Xin AU - Hanig, Joseph P AU - Paule, Merle G AU - Slikker, William AU - Wang, Cheng AD - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 149 EP - 158 VL - 108 IS - 1 KW - Receptors, N-Methyl-D-Aspartate KW - 0 KW - Ketamine KW - 690G0D6V8H KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Rats KW - Animals KW - In Situ Hybridization KW - Analysis of Variance KW - Apoptosis KW - Random Allocation KW - Male KW - Female KW - Caspase 3 -- metabolism KW - Ketamine -- toxicity KW - Brain -- metabolism KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Brain -- ultrastructure KW - Receptors, N-Methyl-D-Aspartate -- genetics KW - Ketamine -- administration & dosage KW - Gene Expression Regulation, Developmental -- drug effects KW - Brain -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66944051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Potential+neurotoxicity+of+ketamine+in+the+developing+rat+brain.&rft.au=Zou%2C+Xiaoju%3BPatterson%2C+Tucker+A%3BSadovova%2C+Natalya%3BTwaddle%2C+Nathan+C%3BDoerge%2C+Daniel+R%3BZhang%2C+Xuan%3BFu%2C+Xin%3BHanig%2C+Joseph+P%3BPaule%2C+Merle+G%3BSlikker%2C+William%3BWang%2C+Cheng&rft.aulast=Zou&rft.aufirst=Xiaoju&rft.date=2009-03-01&rft.volume=108&rft.issue=1&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfn270 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-10 N1 - Date created - 2009-02-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anesth Analg. 2002 Sep;95(3):531-6, table of contents [12198030] Toxicol Sci. 2007 Jul;98(1):145-58 [17426105] Brain Pathol. 2002 Oct;12(4):488-98 [12408236] Paediatr Anaesth. 2002 Nov;12(9):770-4 [12519135] J Neurosci. 2003 Feb 1;23(3):876-82 [12574416] Anesthesiology. 2004 Aug;101(2):527-30 [15277935] Toxicol Sci. 2004 Oct;81(2):364-70 [15254342] Br J Anaesth. 1981 Jan;53(1):27-30 [7459184] Br J Anaesth. 1981 Dec;53(12):1321-3 [7317250] Exp Neurol. 1985 Sep;89(3):503-19 [4029332] Isr J Med Sci. 1986 May;22(5):385-6 [3744788] Nature. 1991 Nov 7;354(6348):31-7 [1834949] Science. 1992 May 22;256(5060):1217-21 [1350383] Mol Pharmacol. 1992 Jul;42(1):147-51 [1353248] Endocrinology. 1993 Feb;132(2):895-902 [8425502] J Pharmacol Exp Ther. 2000 Jul;294(1):287-95 [10871324] Anesth Analg. 2001 Apr;92(4):927-9 [11273928] Biochem Pharmacol. 2001 Aug 15;62(4):401-5 [11448448] Neuropharmacology. 1995 Apr;34(4):411-7 [7566472] Neuron. 1996 Sep;17(3):413-22 [8816705] J Neurosci Res. 1998 Jun 15;52(6):709-22 [9669320] Anesth Analg. 1998 Aug;87(2):266-71 [9706914] Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11435-9 [9736754] Anesth Analg. 1998 Nov;87(5):1186-93 [9806706] Science. 1999 Jan 1;283(5398):70-4 [9872743] Reprod Toxicol. 2005 Jan-Feb;19(3):305-19 [15686866] Brain Res. 2005 Feb 21;1035(1):24-31 [15713273] Neuroscience. 2005;132(4):967-77 [15857702] Toxicol Sci. 2006 May;91(1):192-201 [16500925] Clin Perinatol. 2002 Sep;29(3):357-72 [12380463] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfn270 ER - TY - JOUR T1 - Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications. AN - 66940967; 19020495 AB - The US Food and Drug Administration (FDA) is currently developing a guidance for industry to replace a previous guidance, "Pharmacokinetics in Patients With Impaired Renal Function--Study Design, Data Analysis, and Impact on Dosing and Labeling" (renal guidance) issued in May 1998. The impact of the 1998 renal guidance was assessed following a survey of 94 new drug applications (NDAs) for small-molecule new molecular entities (NMEs) approved over the past 5 years (2003-2007). The survey results indicate that 57% of these NDAs included renal impairment study data, that 44% of those with renal data included evaluation in patients on hemodialysis, and that 41% of those with renal data resulted in recommendation of dose adjustment in renal impairment. In addition, the survey results provided evidence that renal impairment can affect the pharmacokinetics of drugs that are predominantly eliminated by nonrenal processes such as metabolism and/or active transport. The latter finding supports our updated recommendation to evaluate pharmacokinetic/pharmacodynamic alterations in renal impairment for those drugs that are mainly eliminated by nonrenal processes, in addition to those that are mainly excreted unchanged by the kidney. JF - Clinical pharmacology and therapeutics AU - Zhang, Y AU - Zhang, L AU - Abraham, S AU - Apparaju, S AU - Wu, T-C AU - Strong, J M AU - Xiao, S AU - Atkinson, A J AU - Thummel, K E AU - Leeder, J S AU - Lee, C AU - Burckart, G J AU - Lesko, L J AU - Huang, S-M AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 305 EP - 311 VL - 85 IS - 3 KW - Drugs, Investigational KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Practice Guidelines as Topic -- standards KW - Humans KW - Kidney Diseases -- metabolism KW - Drugs, Investigational -- metabolism KW - Investigational New Drug Application KW - Drugs, Investigational -- adverse effects KW - Drugs, Investigational -- administration & dosage KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66940967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Assessment+of+the+impact+of+renal+impairment+on+systemic+exposure+of+new+molecular+entities%3A+evaluation+of+recent+new+drug+applications.&rft.au=Zhang%2C+Y%3BZhang%2C+L%3BAbraham%2C+S%3BApparaju%2C+S%3BWu%2C+T-C%3BStrong%2C+J+M%3BXiao%2C+S%3BAtkinson%2C+A+J%3BThummel%2C+K+E%3BLeeder%2C+J+S%3BLee%2C+C%3BBurckart%2C+G+J%3BLesko%2C+L+J%3BHuang%2C+S-M&rft.aulast=Zhang&rft.aufirst=Y&rft.date=2009-03-01&rft.volume=85&rft.issue=3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.208 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2008.208 ER - TY - JOUR T1 - Monitoring for hepatotoxicity: what is the predictive value of liver "function" tests? AN - 66940134; 19129750 AB - Drug-induced liver injury (DILI) is a major reason drugs fail during development or are withdrawn from the market. The ability to predict, detect, and avoid DILI through appropriate patient selection and effective monitoring has proved to be an elusive goal. Many approved drugs have labeling recommendations for serum enzyme monitoring intended to detect and prevent hepatotoxicity, but such monitoring is often seen as inconvenient, uncomfortable, costly, and inefficient by both patients and doctors, and thus monitoring recommendations are poorly followed, if at all. This review considers whether monitoring works to prevent DILI, whether monitoring recommendations are derived from data or opinions, and whether any better alternatives exist. JF - Clinical pharmacology and therapeutics AU - Senior, J R AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. john.senior@fda.hhs.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 331 EP - 334 VL - 85 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Humans KW - Predictive Value of Tests KW - Liver Function Tests -- standards KW - Liver Function Tests -- methods KW - Drug Monitoring -- methods KW - Drug-Related Side Effects and Adverse Reactions -- chemically induced KW - Drug Monitoring -- standards KW - Chemical and Drug Induced Liver Injury KW - Drug-Related Side Effects and Adverse Reactions -- diagnosis KW - Drug-Related Side Effects and Adverse Reactions -- metabolism KW - Liver Diseases -- diagnosis KW - Liver Diseases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66940134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Monitoring+for+hepatotoxicity%3A+what+is+the+predictive+value+of+liver+%22function%22+tests%3F&rft.au=Senior%2C+J+R&rft.aulast=Senior&rft.aufirst=J&rft.date=2009-03-01&rft.volume=85&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.262 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2008.262 ER - TY - JOUR T1 - Perspectives on early communication of drug risks to the public. AN - 66937729; 19158665 JF - Clinical pharmacology and therapeutics AU - Seligman, P J AU - Osborne, S F AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. paul.seligman@fda.hhs.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 335 EP - 339 VL - 85 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - Patient Education as Topic -- methods KW - Risk Factors KW - Humans KW - Patient Education as Topic -- trends KW - Public Health -- methods KW - Drug-Related Side Effects and Adverse Reactions KW - Adverse Drug Reaction Reporting Systems -- trends KW - Communication KW - Public Health -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66937729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Perspectives+on+early+communication+of+drug+risks+to+the+public.&rft.au=Seligman%2C+P+J%3BOsborne%2C+S+F&rft.aulast=Seligman&rft.aufirst=P&rft.date=2009-03-01&rft.volume=85&rft.issue=3&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.272 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-02-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Pharmacol Ther. 2009 Mar;85(3):225-8 [19223873] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2008.272 ER - TY - JOUR T1 - Screening for serious mental illness in the National Survey on Drug Use and Health (NSDUH). AN - 66923369; 19217004 JF - Annals of epidemiology AU - Colpe, Lisa J AU - Epstein, Joan F AU - Barker, Peggy R AU - Gfroerer, Joseph C AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA. Lisa.Colpe@SAMHSA.hhs.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 210 EP - 211 VL - 19 IS - 3 KW - Index Medicus KW - Young Adult KW - Interview, Psychological KW - Reproducibility of Results KW - Humans KW - Adult KW - Activities of Daily Living KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Mass Screening -- methods KW - Male KW - Female KW - Mental Disorders -- diagnosis KW - Community Mental Health Services -- organization & administration KW - Mental Disorders -- epidemiology KW - Community Mental Health Services -- methods KW - Mental Disorders -- psychology KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66923369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+epidemiology&rft.atitle=Screening+for+serious+mental+illness+in+the+National+Survey+on+Drug+Use+and+Health+%28NSDUH%29.&rft.au=Colpe%2C+Lisa+J%3BEpstein%2C+Joan+F%3BBarker%2C+Peggy+R%3BGfroerer%2C+Joseph+C&rft.aulast=Colpe&rft.aufirst=Lisa&rft.date=2009-03-01&rft.volume=19&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Annals+of+epidemiology&rft.issn=1873-2585&rft_id=info:doi/10.1016%2Fj.annepidem.2008.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-05 N1 - Date created - 2009-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.annepidem.2008.09.005 ER - TY - JOUR T1 - Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells. AN - 66899188; 19152381 AB - We hypothesized that chlorophyllin (CHLN) would reduce benzo[a]pyrene-DNA (BP-DNA) adduct levels. Using normal human mammary epithelial cells (NHMECs) exposed to 4 microM BP for 24 hr in the presence or absence of 5 microM CHLN, we measured BP-DNA adducts by chemiluminescence immunoassay (CIA). The protocol included the following experimental groups: BP alone, BP given simultaneously with CHLN (BP+CHLN) for 24 hr, CHLN given for 24 hr followed by BP for 24 hr (preCHLN, postBP), and CHLN given for 48 hr with BP added for the last 24 hr (preCHLN, postBP+CHLN). Incubation with CHLN decreased BPdG levels in all groups, with 87% inhibition in the preCHLN, postBP+CHLN group. To examine metabolic mechanisms, we monitored expression by Affymetrix microarray (U133A), and found BP-induced up-regulation of CYP1A1 and CYP1B1 expression, as well as up-regulation of groups of interferon-inducible, inflammation and signal transduction genes. Incubation of cells with CHLN and BP in any combination decreased expression of many of these genes. Using reverse transcription real time PCR (RT-PCR) the maximal inhibition of BP-induced gene expression, >85% for CYP1A1 and >70% for CYP1B1, was observed in the preCHLN, postBP+CHLN group. To explore the relationship between transcription and enzyme activity, the ethoxyresorufin-O-deethylase (EROD) assay was used to measure the combined CYP1A1 and CYP1B1 activities. BP exposure caused the EROD levels to double, when compared with the unexposed controls. The CHLN-exposed groups all showed EROD levels similar to the unexposed controls. Therefore, the addition of CHLN to BP-exposed cells reduced BPdG formation and CYP1A1 and CYP1B1 expression, but EROD activity was not significantly reduced. (c) 2008 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Keshava, Channa AU - Divi, Rao L AU - Einem, Tracey L AU - Richardson, Diana L AU - Leonard, Sarah L AU - Keshava, Nagalakshmi AU - Poirier, Miriam C AU - Weston, Ainsley AD - Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA. Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 134 EP - 144 VL - 50 IS - 2 KW - Antimutagenic Agents KW - 0 KW - Chlorophyllides KW - DNA Adducts KW - benzo(a)pyrene-DNA adduct KW - chlorophyllin KW - 1D276TYV9O KW - Benzo(a)pyrene KW - 3417WMA06D KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1B1 KW - Index Medicus KW - Gene Expression -- drug effects KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Reverse Transcriptase Polymerase Chain Reaction KW - Epithelial Cells -- metabolism KW - Gene Expression Profiling KW - Epithelial Cells -- drug effects KW - Epithelial Cells -- enzymology KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Luminescent Measurements KW - Female KW - Mammary Glands, Human -- cytology KW - Cytochrome P-450 CYP1A1 -- genetics KW - Antimutagenic Agents -- pharmacology KW - Mammary Glands, Human -- enzymology KW - Cytochrome P-450 Enzyme System -- genetics KW - Mammary Glands, Human -- metabolism KW - Chlorophyllides -- pharmacology KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Mammary Glands, Human -- drug effects KW - DNA Adducts -- metabolism KW - Benzo(a)pyrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66899188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Chlorophyllin+significantly+reduces+benzo%5Ba%5Dpyrene-DNA+adduct+formation+and+alters+cytochrome+P450+1A1+and+1B1+expression+and+EROD+activity+in+normal+human+mammary+epithelial+cells.&rft.au=Keshava%2C+Channa%3BDivi%2C+Rao+L%3BEinem%2C+Tracey+L%3BRichardson%2C+Diana+L%3BLeonard%2C+Sarah+L%3BKeshava%2C+Nagalakshmi%3BPoirier%2C+Miriam+C%3BWeston%2C+Ainsley&rft.aulast=Keshava&rft.aufirst=Channa&rft.date=2009-03-01&rft.volume=50&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20449 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-27 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FASEB J. 1996 Jun;10(8):809-18 [8666157] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9776-81 [8790407] Science. 1996 Oct 18;274(5286):430-2 [8832894] J Steroid Biochem Mol Biol. 1997 Jun;62(2-3):223-32 [9393958] Environ Mol Mutagen. 1997;30(4):468-74 [9435888] Carcinogenesis. 1998 Feb;19(2):291-8 [9498279] Oncogene. 1998 Jun 18;16(24):3203-10 [9671400] Mutat Res. 1998 Mar 20;399(2):245-53 [9672663] Carcinogenesis. 1998 Jul;19(7):1323-6 [9683196] Carcinogenesis. 1998 Aug;19(8):1389-92 [9744534] Toxicol Appl Pharmacol. 1999 Jul 15;158(2):132-40 [10406928] Mutat Res. 1999 Jul 15;443(1-2):139-47 [10415437] Mol Pharmacol. 1999 Oct;56(4):760-7 [10496959] Mar Biotechnol (NY). 2004 Jul-Aug;6(4):307-11 [15546046] Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):106-14 [15688365] Cancer Lett. 2005 Apr 28;221(2):213-24 [15808407] Occup Environ Med. 2005 Aug;62(8):531-7 [16046605] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2030-4 [16103456] Cancer Res. 2005 Sep 1;65(17):8034-41 [16140978] Int J Cancer. 2006 Aug 15;119(4):741-4 [16557573] Cancer Res. 2007 Jan 15;67(2):812-7 [17234793] Carcinogenesis. 2007 Mar;28(3):611-24 [16973675] Carcinogenesis. 2008 Feb;29(2):227-36 [18174242] Hum Exp Toxicol. 2000 Oct;19(10):573-95 [11211997] Exp Lung Res. 2001 Apr-May;27(3):245-53 [11293327] Environ Sci Technol. 2001 Apr 15;35(8):1630-6 [11329713] Cancer Res. 2001 Sep 15;61(18):6679-81 [11559534] Free Radic Res. 2001 Nov;35(5):563-74 [11767414] Methods. 2001 Dec;25(4):402-8 [11846609] Appl Occup Environ Hyg. 2002 May;17(5):379-86 [12018402] Carcinogenesis. 2002 Dec;23(12):2043-9 [12507927] Mutat Res. 2003 Feb-Mar;523-524:209-16 [12628519] Toxicol Appl Pharmacol. 2003 Feb 15;187(1):1-10 [12628579] J Biochem. 2003 May;133(5):583-92 [12801909] Cancer Sci. 2004 Jan;95(1):1-6 [14720319] Toxicology. 2004 Mar 1;196(1-2):117-25 [15036761] Methods Mol Biol. 2004;274:159-71 [15187278] Environ Health Perspect. 2004 Jun;112(9):970-8 [15198916] J Biomol Struct Dyn. 2004 Aug;22(1):45-50 [15214804] Lung Cancer. 2004 Sep;45(3):289-97 [15301869] J Biol Chem. 1976 Aug 25;251(16):4882-90 [821945] Int J Cancer. 1979 Feb;23(2):201-8 [761942] In Vitro. 1980 May;16(5):415-25 [6993343] Mol Biol Med. 1989 Apr;6(2):169-78 [2693891] Carcinogenesis. 1990 Sep;11(9):1611-9 [2401051] Nucleic Acids Res. 1991 Aug 11;19(15):4293 [1870982] Chem Res Toxicol. 1991 Jul-Aug;4(4):391-407 [1912325] Carcinogenesis. 1993 Jan;14(1):127-33 [8425261] Mutat Res. 1993 Jun;287(2):293-305 [7685489] Environ Health Perspect. 1993 Mar;99:237-9 [8319632] Carcinogenesis. 1994 Apr;15(4):763-6 [8149493] Mutat Res. 1994 Jul 16;308(2):191-203 [7518046] Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8413-7 [8078896] Cancer Res. 1995 Jan 1;55(1):57-62 [7805041] Cancer Detect Prev. 1995;19(3):258-67 [7750114] J Occup Environ Med. 1995 Jan;37(1):52-8 [7620943] Chem Res Toxicol. 1995 Jun;8(4):506-14 [7548730] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20449 ER - TY - JOUR T1 - Investing in Health Information Infrastructure: Can it Help Achieve Health Reform? AN - 58807521; 2008-291281 AB - Health care reform has reemerged as a policy imperative. Congressional discussions regarding sizable federal investments in health information technology (IT) infrastructure have revitalized the vision of health IT as a critical component of accelerating improvements in the quality and value of health care for all Americans. Policymakers will be challenged to link investments in the health information infrastructure to the objectives of health care reform. The purpose of this paper is to articulate some near- and long-term steps that increase the likelihood of achieving high-value health care with the aid of health IT. Adapted from the source document. JF - Health Affairs AU - Clancy, Carolyn M AU - Anderson, Kristine Martin AU - White, P Jon AD - Agency for Healthcare Research and Quality (AHRQ), Rockville, Maryland Carolyn.Clancy@ahrq.hhs.gov Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 478 EP - 482 PB - Project HOPE, Bethesda MD VL - 28 IS - 2 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Medicine and health care KW - Economic conditions and policy - Economic policy, planning, and development KW - Economic conditions and policy - Economic theory KW - Science and technology policy - Computer science and information technology KW - Infrastructure KW - Value KW - Information technology KW - Health policy KW - Medical service KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58807521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Investing+in+Health+Information+Infrastructure%3A+Can+it+Help+Achieve+Health+Reform%3F&rft.au=Clancy%2C+Carolyn+M%3BAnderson%2C+Kristine+Martin%3BWhite%2C+P+Jon&rft.aulast=Clancy&rft.aufirst=Carolyn&rft.date=2009-03-01&rft.volume=28&rft.issue=2&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.28.2.478 LA - English DB - PAIS Index N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health policy; Medical service; Infrastructure; Value; Information technology DO - http://dx.doi.org/10.1377/hlthaff.28.2.478 ER - TY - JOUR T1 - Degasification system selection for US longwall mines using an expert classification system AN - 50402835; 2009-060509 AB - Methane emissions from the active face areas and from the fractured formations overlying the mined coalbed can affect safety and productivity in longwall mines. Since ventilation alone may not be sufficient to control the methane levels on a longwall operation, gob vent boreholes (GVB), horizontal and vertical drainage boreholes, and their combinations are drilled and used as supplementary methane control measures in many mines. However, in most cases, the types of degasification wellbores chosen are decided based on previous experiences without analyzing the different factors that may affect this decision. This study describes the development of an expert classification system used as a decision tool. It was built using a multilayer perceptron (MLP) type artificial neural network (ANN) structure. The ANN was trained using different geographical locations, longwall operation parameters, and coalbed characteristics as input and was tested to classify the output into four different selections, which are actual degasification designs that US longwall mines utilize. The ANN network selected no degasification, GVB, horizontal and GVB, and horizontal, vertical and GVB options with high accuracy. The results suggest that the model can be used as a decision tool for degasification system selection using site- and mine-specific conditions. Such a model can also be used as a screening tool to decide which degasification design should be investigated in detail with more complex numerical techniques. JF - Computers & Geosciences AU - Ozgen Karacan, C Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 515 EP - 526 PB - Elsevier, Amsterdam VL - 35 IS - 3 SN - 0098-3004, 0098-3004 KW - United States KW - mining KW - technology KW - degasification KW - underground mining KW - expert systems KW - data processing KW - aliphatic hydrocarbons KW - ventilation KW - controls KW - mining geology KW - data bases KW - neural networks KW - methane KW - principal components analysis KW - statistical analysis KW - pollution KW - alkanes KW - organic compounds KW - safety KW - longwall mining KW - classification KW - hydrocarbons KW - design KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50402835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+%26+Geosciences&rft.atitle=Degasification+system+selection+for+US+longwall+mines+using+an+expert+classification+system&rft.au=Ozgen+Karacan%2C+C&rft.aulast=Ozgen+Karacan&rft.aufirst=C&rft.date=2009-03-01&rft.volume=35&rft.issue=3&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Computers+%26+Geosciences&rft.issn=00983004&rft_id=info:doi/10.1016%2Fj.cageo.2008.02.029 L2 - http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5840&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e5198452fad934c6346f38b57511c8e0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2009-01-01 N1 - SuppNotes - Supplemental information/data is available in the online version of this article N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; classification; controls; data bases; data processing; degasification; design; expert systems; hydrocarbons; longwall mining; methane; mining; mining geology; neural networks; organic compounds; pollution; principal components analysis; safety; statistical analysis; technology; underground mining; United States; ventilation DO - http://dx.doi.org/10.1016/j.cageo.2008.02.029 ER - TY - JOUR T1 - Reservoir rock properties of coal measure strata of the lower Monongahela Group, Greene County (southwestern Pennsylvania), from methane control and production perspectives AN - 50113306; 2010-004047 AB - The methane emission rate into an underground mine environment from overburden strata during longwall mining is impacted by reservoir and geomechanical characteristics of the coal measure rocks in the overlying strata, as well as the presence of any coal seam. The reservoir characteristics and how they change during mining potentially affect the performance of gob gas ventholes, which consequently impacts the efficiency of methane control in the mining environment. This study presents reservoir and elastic properties of coal measure rocks in the Lower Monongahela Group in Greene County, southwestern Pennsylvania, of the Northern Appalachian Basin. Since the source of methane in this region from underground mining is located between the Sewickley coal and the Pittsburgh coal, a specific emphasis was given to this interval. Core analyses were performed in the laboratory to determine rock porosity and permeability. Geophysical logging data (gamma, density, sonic) obtained from two exploration boreholes were used for evaluating formation boundaries, shale contents, log porosities, and geomechanical properties of formations. Permeability was also calculated using density-log data and empirical equations and compared with laboratory measurements and slug tests performed in isolated intervals of boreholes. The results presented in this study can be used as data sources for reservoir studies related to the production and control of methane. JF - International Journal of Coal Geology AU - Karacan, C Ozgen Y1 - 2009/03// PY - 2009 DA - March 2009 SP - 47 EP - 64 PB - Elsevier, Amsterdam VL - 78 IS - 1 SN - 0166-5162, 0166-5162 KW - United States KW - mining KW - underground mining KW - Pennsylvanian KW - natural gas KW - aliphatic hydrocarbons KW - petroleum KW - production KW - reservoir rocks KW - Appalachian Basin KW - North America KW - mines KW - methane KW - well logs KW - Paleozoic KW - coal mines KW - Carboniferous KW - mechanical properties KW - alkanes KW - porosity KW - organic compounds KW - safety KW - longwall mining KW - boreholes KW - Monongahela Group KW - hydrocarbons KW - Greene County Pennsylvania KW - coalbed methane KW - Pennsylvania KW - permeability KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50113306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Reservoir+rock+properties+of+coal+measure+strata+of+the+lower+Monongahela+Group%2C+Greene+County+%28southwestern+Pennsylvania%29%2C+from+methane+control+and+production+perspectives&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2009-03-01&rft.volume=78&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.10.005 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; Appalachian Basin; boreholes; Carboniferous; coal mines; coalbed methane; Greene County Pennsylvania; hydrocarbons; longwall mining; mechanical properties; methane; mines; mining; Monongahela Group; natural gas; North America; organic compounds; Paleozoic; Pennsylvania; Pennsylvanian; permeability; petroleum; porosity; production; reservoir rocks; safety; underground mining; United States; well logs DO - http://dx.doi.org/10.1016/j.coal.2008.10.005 ER - TY - JOUR T1 - Is perceived racial privilege associated with health? Findings from the behavioral risk factor surveillance system AN - 37140299; 3868852 AB - While racial discrimination has gained increasing attention in public health research, little is known about perceived racial privilege and health. Using the Behavioral Risk Factor Surveillance System (BRFSS) data, this study explored the relationship of both perceived racial discrimination and privilege with well-being in the USA. Data were extracted from the BRFSS 2004 data set, in which 22,412 respondents in seven states and one major city provided data on perceived racial discrimination and privilege at work. Logistic regression analysis was conducted to examine the relationships of differential racial treatment to self-rated general health status and the number of physically and mentally unhealthy days. Racially stratified analyses found that perceived racial privilege was significantly associated with more days of poor physical and mental health. This relationship was consistent for Whites, but for racial minorities it appeared on only some outcome measures. Reports of being treated worse than other races in the workplace were associated with poor health for all racial groups, as had been reported in previous studies on racial discrimination. Because racial discrimination and racial privilege are both products of racism, this study's findings suggest that racism may harm all involved. Impacts of perceived racial privilege deserve more attention in the literature on racism and health. All rights reserved, Elsevier JF - Social science and medicine AU - Fujishiro, Kaori AD - National Institute for Occupational Safety and Health, Cincinnati Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 840 EP - 844 VL - 68 IS - 5 SN - 0277-9536, 0277-9536 KW - Sociology KW - Self-evaluation KW - Comparative advantage KW - Perception KW - Racial discrimination KW - Well-being KW - Health KW - U.S.A. UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37140299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+science+and+medicine&rft.atitle=Is+perceived+racial+privilege+associated+with+health%3F+Findings+from+the+behavioral+risk+factor+surveillance+system&rft.au=Fujishiro%2C+Kaori&rft.aulast=Fujishiro&rft.aufirst=Kaori&rft.date=2009-03-01&rft.volume=68&rft.issue=5&rft.spage=840&rft.isbn=&rft.btitle=&rft.title=Social+science+and+medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2008.12.007 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10566 3612 3549 2688 2449 10404; 2629; 9382; 5772; 11474 4551; 13530 13521; 433 293 14 DO - http://dx.doi.org/10.1016/j.socscimed.2008.12.007 ER - TY - JOUR T1 - Rank-based estimation and associated inferences for linear models with cluster correlated errors AN - 37124235; 3861697 JF - Journal of the American Statistical Association AU - Kloke, John D AU - McKean, Joseph W AU - Rashid, M Mushfiqur AD - Bucknell University ; Western Michigan University ; Food and Drug Administration, USA Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 384 EP - 390 VL - 104 IS - 485 SN - 0162-1459, 0162-1459 KW - Economics KW - Error correction models KW - Distribution KW - Regression analysis KW - Cluster analysis KW - Linear models KW - Estimation KW - Correlation KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37124235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Rank-based+estimation+and+associated+inferences+for+linear+models+with+cluster+correlated+errors&rft.au=Kloke%2C+John+D%3BMcKean%2C+Joseph+W%3BRashid%2C+M+Mushfiqur&rft.aulast=Kloke&rft.aufirst=John&rft.date=2009-03-01&rft.volume=104&rft.issue=485&rft.spage=384&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2Fjasa.2009.0116 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4403 7854; 10739 12228 10919; 3641 12233; 7419 8163; 2400 3279 971 3286 12224; 2904 12224 971; 4389 3864 8163; 12228 10919 DO - http://dx.doi.org/10.1198/jasa.2009.0116 ER - TY - JOUR T1 - Development of a Test System To Apply Virus-Containing Particles to Filtering Facepiece Respirators for the Evaluation of Decontamination Procedures AN - 21485721; 12510674 AB - A chamber to apply aerosolized virus-containing particles to air-permeable substrates (coupons) was constructed and validated as part of a method to assess the virucidal efficacy of decontamination procedures for filtering facepiece respirators. Coliphage MS2 was used as a surrogate for pathogenic viruses for confirmation of the efficacy of the bioaerosol respirator test system. The distribution of virus applied onto and within the coupons was characterized, and the repeatability of applying a targeted virus load was examined. The average viable virus loaded onto 90 coupons over the course of 5 days was found to be 5.09 c 0.19 log10 PFU/coupon (relative standard deviation, 4%). To determine the ability to differentiate the effectiveness of disinfecting procedures with different levels of performance, sodium hypochlorite and steam treatments were tested in experiments by varying the dose and time, respectively. The role of protective factors was assessed by aerosolizing the virus with various concentrations of the aerosol-generating medium. A sodium hypochlorite (bleach) concentration of 0.6% and steam treatments of 45 s and longer resulted in log reductions (>4 logs) which reached the detection limits for both levels of protective factors. Organic matter (ATCC medium 271) as a protective factor afforded some protection to the virus in the sodium hypochlorite experiments but was not a factor in the steam experiments. The evaluation of the bioaerosol respirator test system demonstrated a repeatable method for applying a targeted viral load onto respirator coupons and provided insight into the properties of aerosols that are of importance to the development of disinfection assays for air-permeable materials. JF - Applied and Environmental Microbiology AU - Fisher, Edward AU - Rengasamy, Samy AU - Viscusi, Dennis AU - Vo, Evanly AU - Shaffer, Ronald AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania 15236, RShaffer@cdc.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 1500 EP - 1507 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 75 IS - 6 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Aerosols KW - Respirators KW - V 22340:Antiviral Agents KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21485721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Development+of+a+Test+System+To+Apply+Virus-Containing+Particles+to+Filtering+Facepiece+Respirators+for+the+Evaluation+of+Decontamination+Procedures&rft.au=Fisher%2C+Edward%3BRengasamy%2C+Samy%3BViscusi%2C+Dennis%3BVo%2C+Evanly%3BShaffer%2C+Ronald&rft.aulast=Fisher&rft.aufirst=Edward&rft.date=2009-03-01&rft.volume=75&rft.issue=6&rft.spage=1500&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01653-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Respirators DO - http://dx.doi.org/10.1128/AEM.01653-08 ER - TY - JOUR T1 - An Analysis of Water Quality in the Colorado River, 2003-04; An Investigation Into Recurring Outbreaks of Norovirus Among Rafters AN - 21085290; 11206199 AB - Background.-Every year over 22000 people raft the Colorado River through the Grand Canyon in Arizona. Since 1994, over 400 rafters in 6 separate outbreaks have become ill with norovirus while rafting this stretch of the river. JF - Wilderness & Environmental Medicine AU - Jones, Ellen L AU - Gaither AU - , Marlene AU - Kramer AU - , Adam AU - Gerba, Charles P AD - From the Department of Soil, Water, and Environmental Science, University of Arizona, Tucson, AZ (Ms Jones and Mr Gerba); Coconino County Health Department, Environmental Health Division, Flagstaff, AZ (Ms Gaither); and the Public Health Service/National Park Service, Intermountain Region, Flagstaff, AZ (Mr Kramer) Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 6 EP - 13 PB - Wilderness Medical Society VL - 20 IS - 1 SN - 1080-6032, 1080-6032 KW - rafting KW - Virology & AIDS Abstracts; Pollution Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts KW - Rivers KW - USA, Arizona, Grand Canyon KW - Rafting KW - Water Quality KW - Norovirus KW - outbreaks KW - Freshwater KW - rivers KW - Water quality KW - canyons KW - Water analysis KW - Boats KW - Recreation areas KW - Wilderness KW - USA, Arizona KW - Canyons KW - H 3000:Environment and Ecology KW - P 2000:FRESHWATER POLLUTION KW - SW 3010:Identification of pollutants KW - Q5 08501:General KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21085290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Early+Pulmonary+Cytokine+and+Chemokine+Responses+in+Mice+Immunized+with+Three+Different+Vaccines+against+Mycobacterium+tuberculosis+Determined+by+PCR+Array+%2C&rft.au=Lim%2C+JaeHyun%3BDerrick%2C+Steven+C%3BKolibab%2C+Kristopher%3BYang%2C+Amy+Li%3BPorcelli%2C+Steven%3BJacobs%2C+William+R%3BMorris%2C+Sheldon+L&rft.aulast=Lim&rft.aufirst=JaeHyun&rft.date=2009-01-01&rft.volume=16&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00359-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Rivers; Rafting; Boats; Water quality; Wilderness; Recreation areas; outbreaks; rivers; Water analysis; canyons; Water Quality; Canyons; Norovirus; USA, Arizona, Grand Canyon; USA, Arizona; Freshwater DO - http://dx.doi.org/10.1580/06-WEME-OR-43.1 ER - TY - JOUR T1 - Comparing model averaging with other model selection strategies for benchmark dose estimation AN - 20930201; 10952867 AB - Model averaging (MA) has been proposed as a method of accommodating model uncertainty when estimating risk. Although the use of MA is inherently appealing, little is known about its performance using general modeling conditions. We investigate the use of MA for estimating excess risk using a Monte Carlo simulation. Dichotomous response data are simulated under various assumed underlying dose--response curves, and nine dose--response models (from the USEPA Benchmark dose model suite) are fit to obtain both model specific and MA risk estimates. The benchmark dose estimates (BMDs) from the MA method, as well as estimates from other commonly selected models, e.g., best fitting model or the model resulting in the smallest BMD, are compared to the true benchmark dose value to better understand both bias and coverage behavior in the estimation procedure. The MA method has a small bias when estimating the BMD that is similar to the bias of BMD estimates derived from the assumed model. Further, when a broader range of models are included in the family of models considered in the MA process, the lower bound estimate provided coverage close to the nominal level, which is superior to the other strategies considered. This approach provides an alternative method for risk managers to estimate risk while incorporating model uncertainty. JF - Environmental and Ecological Statistics AU - Wheeler, Matthew W AU - Bailer, A John AD - Risk Evaluation Branch, National Institute for Occupational Safety and Health, MS C-15, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, aez0@cdc.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 37 EP - 51 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 16 IS - 1 SN - 1352-8505, 1352-8505 KW - Ecology Abstracts KW - Monte Carlo simulation KW - Bone mineral density KW - Data processing KW - Statistics KW - benchmarks KW - Cadmium KW - Models KW - D 04030:Models, Methods, Remote Sensing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20930201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Ecological+Statistics&rft.atitle=Comparing+model+averaging+with+other+model+selection+strategies+for+benchmark+dose+estimation&rft.au=Wheeler%2C+Matthew+W%3BBailer%2C+A+John&rft.aulast=Wheeler&rft.aufirst=Matthew&rft.date=2009-03-01&rft.volume=16&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Ecological+Statistics&rft.issn=13528505&rft_id=info:doi/10.1007%2Fs10651-007-0071-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Monte Carlo simulation; Statistics; Data processing; Bone mineral density; Models; benchmarks; Cadmium DO - http://dx.doi.org/10.1007/s10651-007-0071-7 ER - TY - RPRT T1 - Environmental Control for Tuberculosis: Basic Upper-Room Ultraviolet Germicidal Irradiation Guidelines for Healthcare Settings AN - 20769939; 10308237 AB - Research indicates that an appropriately designed and maintained upper-room UVGI system may kill or inactivate airborne TB bacteria and increase the protection afforded to healthcare workers while maintaining a safe level of UVGI in the occupied lower portion of the room. The purpose of this document is to examine the different parameters necessary for an effective upper-room UVGI system and to provide guidelines to healthcare managers, facility designers, engineers, and industrial hygienists on the parameters necessary to install and maintain an effective upper-room UVGI system. These guidelines are consistent with previous CDC healthcare guidelines and expand upon them. This document provides an overview of the current knowledge concerning upper-room UVGI systems and research needs. Information from CDC/NIOSH-funded laboratory studies and other relevant studies is combined in this report to provide guidelines for the installation and use of upper-room UVGI systems. Although other pathogenic microorganisms may be killed or inactivated by upper-room UVGI systems, the guidelines were developed for the installation and use of upper-room UVGI systems capable of killing or inactivating surrogates of mycobacteria. JF - Environmental Control for Tuberculosis: Basic Upper-Room Ultraviolet Germicidal Irradiation Guidelines for Healthcare Settings. [np]. Mar 2009. AU - Anonymous Y1 - 2009/03// PY - 2009 DA - Mar 2009 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Mycobacterium KW - Medical personnel KW - tuberculosis KW - U.V. radiation KW - Health care KW - guidelines KW - Irradiation KW - Reviews KW - Microorganisms KW - Tuberculosis KW - A 01340:Antibiotics & Antimicrobials KW - H 1000:Occupational Safety and Health KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20769939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Bacteriology+Abstracts+%28Microbiology+B%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Environmental+Control+for+Tuberculosis%3A+Basic+Upper-Room+Ultraviolet+Germicidal+Irradiation+Guidelines+for+Healthcare+Settings&rft.title=Environmental+Control+for+Tuberculosis%3A+Basic+Upper-Room+Ultraviolet+Germicidal+Irradiation+Guidelines+for+Healthcare+Settings&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 ER - TY - JOUR T1 - Heterocyclic aromatic amine pesticide use and human cancer risk: Results from the U.S. Agricultural Health Study AN - 20629553; 9356163 AB - Imazethapyr, a heterocyclic aromatic amine, is a widely used crop herbicide first registered for use in the United States in 1989. We evaluated cancer incidence among imazethapyr-exposed pesticide applicators enrolled in the Agricultural Health Study (AHS). The AHS is a prospective cohort of 57,311 licensed pesticide applicators in the U.S., enrolled from 1993-1997. Among the 49,398 licensed pesticide applicators eligible for analysis, 20,646 applicators reported use of imazethapyr and 2,907 incident cancers developed through 2004. Imazethapyr exposure was classified by intensity-weighted lifetime exposure days calculated as [years of use X days per year X intensity level]. Poisson regression analysis was used to evaluate the relationship between imazethapyr exposure and cancer incidence. We found significant trends in risk with increasing lifetime exposure for bladder cancer (p for trend 0.01) and colon cancer (p for trend 0.02). Rate ratios (RRs) were increased by 137% for bladder cancer and 78% for colon cancer when the highest exposed were compared to the nonexposed. The excess risk for colon cancer was limited to proximal cancers, (RR = 2.73, 95% confidence intervals 1.42, 5.25, p for trend 0.001). No association was observed for prostate, lung, rectum, kidney, oral, pancreas, lymphohematopoietic cancers or melanoma. These findings provide new evidence that exposure to aromatic amine pesticides may be an overlooked exposure in the etiology of bladder and colon cancer. The use of imazethapyr and other imidazolinone compounds should continue to be evaluated for potential risk to humans. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Koutros, Stella AU - Lynch, Charles F AU - Ma, Xiaomei AU - Lee, Won Jin AU - Hoppin, Jane A AU - Christensen, Carol H AU - Andreotti, Gabriella AU - Freeman, Laura Beane AU - Rusiecki, Jennifer A AU - Hou, Lifang AU - Sandler, Dale P AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, KoutrosS@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 1206 EP - 1212 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 5 SN - 0020-7136, 0020-7136 KW - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - Pancreas KW - Crops KW - Pancreatic cancer KW - Colon cancer KW - Amines KW - Prostate KW - Aromatics KW - Rectum KW - Melanoma KW - urinary bladder KW - amines KW - Regression analysis KW - Imidazolinones KW - Etiology KW - Urinary bladder KW - Herbicides KW - melanoma KW - Cancer KW - USA KW - Lung KW - Pesticides KW - Kidney KW - H 5000:Pesticides KW - R2 23060:Medical and environmental health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20629553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Heterocyclic+aromatic+amine+pesticide+use+and+human+cancer+risk%3A+Results+from+the+U.S.+Agricultural+Health+Study&rft.au=Koutros%2C+Stella%3BLynch%2C+Charles+F%3BMa%2C+Xiaomei%3BLee%2C+Won+Jin%3BHoppin%2C+Jane+A%3BChristensen%2C+Carol+H%3BAndreotti%2C+Gabriella%3BFreeman%2C+Laura+Beane%3BRusiecki%2C+Jennifer+A%3BHou%2C+Lifang%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+C+R&rft.aulast=Koutros&rft.aufirst=Stella&rft.date=2009-03-01&rft.volume=124&rft.issue=5&rft.spage=1206&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Cancer; Pesticides; Amines; urinary bladder; melanoma; Kidney; Crops; Herbicides; Lung; Etiology; Urinary bladder; Melanoma; Colon cancer; Aromatics; amines; Rectum; Imidazolinones; Prostate; Regression analysis; Pancreatic cancer; Pancreas DO - http://dx.doi.org/10.1002/ijc.24020 ER - TY - JOUR T1 - Probiotic bacteria are antagonistic to Salmonella enterica and Campylobacter jejuni and influence host lymphocyte responses in human microbiota-associated immunodeficient and immunocompetent mice AN - 20589662; 9307092 AB - A defined human microbiota-associated (HMA) mouse model in BALB/c and immunodeficient Tg26 mice was used to assess the ability of probiotic lactobacilli and bifidobacteria to enhance colonization resistance to gastrointestinal (GI) tract pathogens. Probiotic bacteria (1X108 colony forming unit (CFU)/mL) successfully excluded Campylobacter jejuni from both strains of mice 7 days after challenge. The probiotic bacteria also reduced the number of Salmonella in the large intestines of both mouse strains. The nylon wool fractionated spleen lymphocyte populations were incubated with Salmonella or C. jejuni antigens. The probiotic treatments did not affect lymphocyte proliferation to C. jejuni antigens, but significantly increased proliferation of lymphocytes to Salmonella antigens by 68 and 55%, respectively, over untreated mice. Caspase 3/7 activation was significantly reduced 33 and 38% in the T and B lymphocyte fractions, respectively, of probiotic-treated, Salmonella-challenged HMA BALB/c mice, suggesting that lymphocyte rescue from apoptosis was occurring as a result of probiotic bacteria activity. These results revealed an immunosuppressive activity by Salmonella that was inhibited by the presence of probiotic bacteria. In summary, lactobacilli and bifidobacteria competitively excluded C. jejuni from immunocompetent and immunodeficient mice and antagonized an observable Salmonella-induced immunosuppression in immunocompetent mice. JF - Molecular Nutrition & Food Research AU - Wagner, Robert Doug AU - Johnson, Shemedia J AU - Rubin, Dedeh Kurniasih AD - National Center for Toxicological Research, USFDA, Jefferson, Arkansas, USA., doug.wagner@fda.hhs.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 377 EP - 388 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 53 IS - 3 SN - 1613-4125, 1613-4125 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Nylon KW - Apoptosis KW - Lymphocytes B KW - Immunodeficiency KW - probiotics KW - Animal models KW - Spleen KW - Large intestine KW - Pathogens KW - Immunosuppressive agents KW - Cell activation KW - Wool KW - Colonization KW - Colonies KW - Lactobacillus KW - Campylobacter jejuni KW - Salmonella enterica KW - Colony-forming cells KW - Caspase-3 KW - Gastrointestinal tract KW - Immunosuppression KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20589662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Nutrition+%26+Food+Research&rft.atitle=Probiotic+bacteria+are+antagonistic+to+Salmonella+enterica+and+Campylobacter+jejuni+and+influence+host+lymphocyte+responses+in+human+microbiota-associated+immunodeficient+and+immunocompetent+mice&rft.au=Wagner%2C+Robert+Doug%3BJohnson%2C+Shemedia+J%3BRubin%2C+Dedeh+Kurniasih&rft.aulast=Wagner&rft.aufirst=Robert&rft.date=2009-03-01&rft.volume=53&rft.issue=3&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Molecular+Nutrition+%26+Food+Research&rft.issn=16134125&rft_id=info:doi/10.1002%2Fmnfr.200800101 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nylon; Apoptosis; Lymphocytes B; Animal models; probiotics; Immunodeficiency; Spleen; Large intestine; Pathogens; Immunosuppressive agents; Cell activation; Wool; Colonization; Colonies; Colony-forming cells; Caspase-3; Gastrointestinal tract; Immunosuppression; Lactobacillus; Salmonella enterica; Campylobacter jejuni DO - http://dx.doi.org/10.1002/mnfr.200800101 ER - TY - JOUR T1 - Development of a Risk-Ranking Framework to Evaluate Potential High-Threat Microorganisms, Toxins, and Chemicals in Food AN - 20542721; 9258421 AB - ABSTRACT:Through a cooperative agreement with the U.S. Food and Drug Administration, the Institute of Food Technologists developed a risk-ranking framework prototype to enable comparison of microbiological and chemical hazards in foods and to assist policy makers, risk managers, risk analysts, and others in determining the relative public health impact of specific hazard-food combinations. The prototype is a bottom-up system based on assumptions that incorporate expert opinion/insight with a number of exposure and hazard-related risk criteria variables, which are propagated forward with food intake data to produce risk-ranking determinations. The prototype produces a semi-quantitative comparative assessment of food safety hazards and the impacts of hazard control measures. For a specific hazard-food combination the prototype can produce a single metric: a final risk value expressed as annual pseudo-disability adjusted life years (pDALY). The pDALY is a harmonization of the very different dose-response relationships observed for chemicals and microbes. The prototype was developed on 2 platforms, a web-based user interface and an Analytica registered model (Lumina Decision Systems, Los Gatos, Calif., U.S.A.). Comprising visual basic language, the web-based platform facilitates data input and allows use concurrently from multiple locations. The Analytica model facilitates visualization of the logic flow, interrelationship of input and output variables, and calculations/algorithms comprising the prototype. A variety of sortable risk-ranking reports and summary information can be generated for hazard-food pairs, showing hazard and dose-response assumptions and data, per capita consumption by population group, and annual p-DALY. JF - Journal of Food Science AU - Newsome, R AU - Tran, N AU - Paoli, G M AU - Jaykus, LA AU - Tompkin, B AU - Miliotis, M AU - Ruthman, T AU - Hartnett, E AU - Busta, F F AU - Petersen, B AU - Shank, F AU - McEntire, J AU - Hotchkiss, J AU - Wagner, M AU - Schaffner, D W AD - 1Authors Newsome and McEntire are with the Inst. of Food Technologists, Chicago, IL 60607, U.S.A. Authors Tran and Petersen are with Exponent, Inc., Washington, DC 20036, U.S.A. Authors Paoli, Ruthman, and Hartnett are with Decisionalysis Risk Consultants, Inc., Ottawa, Ontario, Canada K1H653. Author Jaykus is with North Carolina State Univ., Raleigh, NC 27695, U.S.A. Author Tompkin is retired from ConAgra, La Grange, IL 60525, U.S.A. Author Miliotis is with the Food and Drug Administration/Center for Food Safety and Applied Nutrition College Park, MD 20740, U.S.A. Author Busta is with the Natl. Center for Food Protection and Defense and Univ. of Minnesota, Minneapolis, MN 55455, U.S.A. Author Shank is retired from the Inst. of Food Technologists, Washington, DC 20036, U.S.A. Author Hotchkiss is with Cornell Univ., Ithaca, NY 14853, U.S.A. Author Wagner is with Mars Symbioscience, Rockville, MD 20850, U.S.A. Author Schaffner is with Rutgers Univ., New Brunswick, NJ 08901, U.S.A. Direct inquiries to Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - R39 EP - R45 PB - Institute of Food Technology VL - 74 IS - 2 SN - 0022-1147, 0022-1147 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - food safety KW - risk KW - risk ranking KW - Data processing KW - Food intake KW - Dose-response effects KW - Algorithms KW - Microorganisms KW - Language KW - Toxins KW - Public health KW - X 24320:Food Additives & Contaminants KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20542721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Development+of+a+Risk-Ranking+Framework+to+Evaluate+Potential+High-Threat+Microorganisms%2C+Toxins%2C+and+Chemicals+in+Food&rft.au=Newsome%2C+R%3BTran%2C+N%3BPaoli%2C+G+M%3BJaykus%2C+LA%3BTompkin%2C+B%3BMiliotis%2C+M%3BRuthman%2C+T%3BHartnett%2C+E%3BBusta%2C+F+F%3BPetersen%2C+B%3BShank%2C+F%3BMcEntire%2C+J%3BHotchkiss%2C+J%3BWagner%2C+M%3BSchaffner%2C+D+W&rft.aulast=Newsome&rft.aufirst=R&rft.date=2009-03-01&rft.volume=74&rft.issue=2&rft.spage=R39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2Fj.1750-3841.2008.01042.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Food intake; Dose-response effects; Microorganisms; Algorithms; Language; Toxins; Public health DO - http://dx.doi.org/10.1111/j.1750-3841.2008.01042.x ER - TY - JOUR T1 - Synopsis of the Food and Drug Administration-National Institute of Standards and Technology Co-Sponsored "In Vitro Analyses of Cell/Scaffold Products" Workshop AN - 20525313; 9209347 AB - Complex, dynamic mixtures of cells and structural components, known as cell/scaffold products, are in development as therapeutics for the repair, replacement, and regeneration of a wide variety of tissues damaged by acute, chronic, degenerative, or congenital diseases. These types of tissue-engineered products hold the potential to treat many diseases and injuries that currently do not have effective treatments. Cell/scaffold products are manufactured using complex regimens of cell expansion, materials processing, and cell-biomaterial integration. A critical step toward commercial availability of cell/scaffold-based therapeutics is the establishment of methods to produce a product that can be manufactured in a consistent and reliable manner. To effectively treat patients' needs, manufacturing processes must be designed to achieve desired, pre-defined product criteria and characteristics. Product inconsistency may also contribute to clinical studies yielding ambiguous data and hinder market approval by the Food and Drug Administration (FDA). JF - Tissue Engineering, Part A: Tissue Engineering AU - McCright, B AU - Dang, J M AU - Hursh, DA AU - Kaplan, D S AU - Ballica, R AU - Benton, KA AU - Plant, AL AD - Office of Cellular, Tissue, and Gene Therapy, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA, brenton.mccright@fda.hhs.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 455 EP - 460 VL - 15 IS - 3 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - Integration KW - Data processing KW - Injuries KW - Conferences KW - Drug development KW - Tissue engineering KW - scaffolds KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20525313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Synopsis+of+the+Food+and+Drug+Administration-National+Institute+of+Standards+and+Technology+Co-Sponsored+%22In+Vitro+Analyses+of+Cell%2FScaffold+Products%22+Workshop&rft.au=McCright%2C+B%3BDang%2C+J+M%3BHursh%2C+DA%3BKaplan%2C+D+S%3BBallica%2C+R%3BBenton%2C+KA%3BPlant%2C+AL&rft.aulast=McCright&rft.aufirst=B&rft.date=2009-03-01&rft.volume=15&rft.issue=3&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2008.0558 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Integration; Data processing; Conferences; Injuries; Drug development; Tissue engineering; scaffolds DO - http://dx.doi.org/10.1089/ten.tea.2008.0558 ER - TY - JOUR T1 - Injuries and fatalities to U.S. farmers and farm workers 55 years and older AN - 20433752; 9119963 AB - Background Previous studies have shown that older farmers and farm workers have been identified at high risk for farm fatalities, most notably involving tractor overturns. Older farmers also incur more severe non-fatal injuries. Methods Data from two national surveillance systems are presented to describe fatal and non-fatal injuries occurring to older farmers 55+ years of age. Tractor-related fatality investigations for older farmers are examined for characteristics of the tractors not available in the injury surveillance systems. Results Older farmers and farm workers averaged 26,573 lost-time injuries annually in 2001 and 2004, with an injury rate of 4.5 injuries/100 workers/year compared to an overall farming injury rate of 4.8 injuries/100 workers/year. Fatality data show that older farmers accounted for over half of all farming deaths between 1992 and 2004 (3,671 of 7,064 deaths), and had a fatality rate of 45.8 deaths/100,000 workers/year compared to the overall farming fatality rate of 25.4 deaths/100,000 workers/year. Most common mechanisms of fatal injury to older farmers were tractors (46%), trucks (7%), and animals (5%). Conclusions Although older farmers and farm workers are at lower risk of overall injury compared to their younger counterparts, injuries to farmers 55 years and older tend to be much more severe. To effectively minimize the risk faced by older farmers, prevention programs must encourage safe work behaviors and practices and the implementation/installation of appropriate safety devices and equipment. Am. J. Ind. Med. 52:185-194, 2009. JF - American Journal of Industrial Medicine AU - Myers, John R AU - Layne, Larry A AU - Marsh, Suzanne M AD - Division of Safety Research, NIOSH, Morgantown, West Virginia, jrmyers@cdc.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 185 EP - 194 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 52 IS - 3 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - risk reduction KW - USA KW - Age KW - Injuries KW - farms KW - prevention KW - Trucks KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20433752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Injuries+and+fatalities+to+U.S.+farmers+and+farm+workers+55+years+and+older&rft.au=Myers%2C+John+R%3BLayne%2C+Larry+A%3BMarsh%2C+Suzanne+M&rft.aulast=Myers&rft.aufirst=John&rft.date=2009-03-01&rft.volume=52&rft.issue=3&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20661 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - risk reduction; Mortality; Age; Injuries; farms; prevention; Trucks; USA DO - http://dx.doi.org/10.1002/ajim.20661 ER - TY - JOUR T1 - Impact of interacting functional variants in COMT on regional gray matter volume in human brain AN - 20392215; 9066223 AB - Background Functional variants in the catechol-O-methyltransferase (COMT) gene have been shown to impact cognitive function, cortical physiology and risk for schizophrenia. A recent study showed that previously reported effects of the functional val158met SNP (rs4680) on brain function are modified by other functional SNPs and haplotypes in the gene, though it was unknown if these effects are also seen in brain structure. Methods We used voxel-based morphometry to investigate the impact of multiple functional variants in COMT on gray matter volume in a large group of 151 healthy volunteers from the CBDB/NIMH Genetic Study of Schizophrenia. Results We found that the previously described rs4680 val risk variant affects hippocampal and dorsolateral prefrontal (DLPFC) gray matter volume. In addition, we found that this SNP interacts with a variant in the P2 promoter region (rs2097603) in predicting changes in hippocampal gray matter volume consistent with a nonlinear effect of extracellular dopamine. Conclusions We report evidence that interacting functional variants in COMT affect gray matter regional volume in hippocampus and DLPFC, providing further in vivo validation of the biological impact of complex genetic variation in COMT on neural systems relevant for the pathophysiology of schizophrenia and extending observations of nonlinear dependence of prefrontal neurons on extracellular dopamine to the domain of human brain structure. JF - NeuroImage AU - Honea, Robyn AU - Verchinski, Beth A AU - Pezawas, Lukas AU - Kolachana, Bhaskar S AU - Callicott, Joseph H AU - Mattay, Venkata S AU - Weinberger, Daniel R AU - Meyer-Lindenberg, Andreas AD - Genes, Cognition and Psychosis Program, National Institute of Mental Health; Division of Intramural Research; National Institutes of Health; Department of Health and Human Services, Rm 4S-235, Bethesda, 20892, USA, Daniel.weinberger@mail.nih.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 44 EP - 51 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 45 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Hippocampus KW - Brain KW - Genetic diversity KW - Schizophrenia KW - Promoters KW - Mental disorders KW - Catechol O-methyltransferase KW - Dopamine KW - Haplotypes KW - Morphometry KW - Cognitive ability KW - Single-nucleotide polymorphism KW - Neurons KW - Substantia grisea KW - N3 11023:Neurogenetics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20392215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Impact+of+interacting+functional+variants+in+COMT+on+regional+gray+matter+volume+in+human+brain&rft.au=Honea%2C+Robyn%3BVerchinski%2C+Beth+A%3BPezawas%2C+Lukas%3BKolachana%2C+Bhaskar+S%3BCallicott%2C+Joseph+H%3BMattay%2C+Venkata+S%3BWeinberger%2C+Daniel+R%3BMeyer-Lindenberg%2C+Andreas&rft.aulast=Honea&rft.aufirst=Robyn&rft.date=2009-03-01&rft.volume=45&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.10.064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hippocampus; Brain; Genetic diversity; Schizophrenia; Promoters; Mental disorders; Dopamine; Catechol O-methyltransferase; Haplotypes; Single-nucleotide polymorphism; Cognitive ability; Morphometry; Neurons; Substantia grisea DO - http://dx.doi.org/10.1016/j.neuroimage.2008.10.064 ER - TY - JOUR T1 - ClassRHO: A platform for classification of bacterial rieske non-heme iron ring-hydroxylating oxygenases AN - 20356786; 9037821 AB - We have developed an easy-to-use multiplatform classification tool, ClassRHO, which facilitates classification and comparison of bacterial Rieske non-heme iron aromatic ring-hydroxylating oxygenases (RHOs). Visualization and analysis can be generated on-the-fly by entering or uploading RHO query sequences. Pre-computed classifications were implemented for 42 standard RHO sequences. These 42 RHO sequences can be flexibly selected based on user requests. ClassRHO provides users with many options to view and analyze RHO sequences. JF - Journal of Microbiological Methods AU - Baek, S AU - Kweon, O AU - Kim, S J AU - Baek, D H AU - Chen, J J AU - Cerniglia, CE AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, jamesJ.chen@fda.hhs.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 307 EP - 309 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 76 IS - 3 SN - 0167-7012, 0167-7012 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacteria KW - Classification KW - Oxygenase KW - Iron KW - Aromatics KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20356786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microbiological+Methods&rft.atitle=ClassRHO%3A+A+platform+for+classification+of+bacterial+rieske+non-heme+iron+ring-hydroxylating+oxygenases&rft.au=Baek%2C+S%3BKweon%2C+O%3BKim%2C+S+J%3BBaek%2C+D+H%3BChen%2C+J+J%3BCerniglia%2C+CE&rft.aulast=Baek&rft.aufirst=S&rft.date=2009-03-01&rft.volume=76&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microbiological+Methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2008.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Classification; Iron; Oxygenase; Aromatics; Bacteria DO - http://dx.doi.org/10.1016/j.mimet.2008.11.003 ER - TY - JOUR T1 - Toxicity value for 3-monochloropropane-1,2-diol using a benchmark dose methodology AN - 20355223; 9037854 AB - 3-Monochloropropane-1,2-diol ( alpha -chlorohydrin, 3-MCPD) is a well-known contaminant that has been detected in a wide range of foods, and that is principally generated in foods prepared by hydrochloric acid hydrolysis, such as acid-hydrolyzed vegetable protein (acid-HVP). 3-MCPD is nephrotoxic to animals at high doses and induced tumors in some organs in both sexes of rodents. NITR have recently reported on the carcinogenicity of 3-MCPD in SD rats that were exposed for 2years to drinking water. We considered that the kidney was the main target organ for 3-MCPD in SD rats and that renal tubular hyperplasia was the most sensitive endpoint. Benchmark dose analysis of the dose-response data for renal tubular hyperplasia in male and female rats exposed to 3-MCPD in drinking water for 2years was conducted. We applied this to the benchmark dose (BMD) methodology to yield a point of departure for developing tolerable daily intakes (TDIs). The calculated BMDs and lower-bound confidence limits (BMDLs) for the critical endpoint were estimated using the seven different models. Predicted doses associated with 10% extra risk were calculated. The smallest Akaike's Information Criterion (AIC) was used in selecting the appropriate model. The model chosen by AIC for males was the logistic and for females it was the multistage. In summary, the predicted BMD sub(1) sub(0) and BMDL sub(1) sub(0) were 1.21mg/kg bw/day and 0.87mg/kg bw/day for the male rat incidence data, and values for female rats were 26.31mg/kg bw /day and 19.47mg/kg bw/day. In this study, the BMDL sub(1) sub(0) of 0.87mg /kg bw/day for male rats was suggested as the point of departure for deriving the human tolerable daily intake level of 3-MCPD. JF - Regulatory Toxicology and Pharmacology AU - Hwang, M AU - Yoon, E AU - Kim, J AU - Jang, D D AU - Yoo, T M AD - Department of Risk Assessment Research, National Institute of Toxicological Research, Korea FDA, 5 Nokbun-dong, Eunpyung-ku, Seoul 122-704, Republic of Korea, taemoo@kfda.go.kr Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 102 EP - 106 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 53 IS - 2 SN - 0273-2300, 0273-2300 KW - Toxicology Abstracts KW - Vegetables KW - Data processing KW - Food KW - Animal models KW - Toxicity KW - Tumors KW - Hydrolysis KW - Models KW - Hyperplasia KW - Bone mineral density KW - Carcinogenicity KW - Kidney KW - Contaminants KW - Drinking water KW - Hydrochloric acid KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20355223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Toxicity+value+for+3-monochloropropane-1%2C2-diol+using+a+benchmark+dose+methodology&rft.au=Hwang%2C+M%3BYoon%2C+E%3BKim%2C+J%3BJang%2C+D+D%3BYoo%2C+T+M&rft.aulast=Hwang&rft.aufirst=M&rft.date=2009-03-01&rft.volume=53&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2008.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Vegetables; Data processing; Food; Animal models; Tumors; Toxicity; Hydrolysis; Models; Hyperplasia; Bone mineral density; Carcinogenicity; Kidney; Drinking water; Contaminants; Hydrochloric acid DO - http://dx.doi.org/10.1016/j.yrtph.2008.12.005 ER - TY - JOUR T1 - Nosocomial Outbreak of Infection With Pan-Drug-Resistant Acinetobacter baumannii in a Tertiary Care University Hospital AN - 20331786; 9013255 AB - Objective.[image]To describe what is, to our knowledge, the first nosocomial outbreak of infection with pan-drug-resistant (including colistin- resistant) Acinetobacter baumannii, to determine the risk factors associated with these types of infections, and to determine their clinical impact. Design.[image]Nested case-control cohort study and a clinical- microbiological study. Setting.[image]A 1,521-bed tertiary care university hospital in Seville, Spain. Patients.[image]Case patients were inpatients who had a pan-drug-resistant A. baumannii isolate recovered from a clinical or surveillance sample obtained at least 48 hours after admission to an intensive care unit (ICU) during the time of the epidemic outbreak. Control patients were patients who were admitted to any of the "boxes" (ie, rooms that partition off a distinct area for a patient's bed and the equipment needed to care for the patient) of an ICU for at least 48 hours during the time of the epidemic outbreak. Results.[image]All the clinical isolates had similar antibiotic susceptibility patterns (ie, they were resistant to all the antibiotics tested, including colistin), and, on the basis of repetitive extragenic palindromic-polymerase chain reaction, it was determined that all of them were of the same clone. The previous use of quinolones and glycopeptides and an ICU stay were associated with the acquisition of infection or colonization with pan-drug-resistant A. baumannii. To control this outbreak, we implemented the following multicomponent intervention program: the performance of environmental decontamination of the ICUs involved, an environmental survey, a revision of cleaning protocols, active surveillance for colonization with pan-drug- resistant A. baumannii, educational programs for the staff, and the display of posters that illustrate contact isolation measures and antimicrobial use recommendations. Conclusions.[image]We were not able to identify the common source for these cases of infection, but the adopted measures have proven to be effective at controlling the outbreak. JF - Infection Control and Hospital Epidemiology AU - Valencia, Raquel AU - Arroyo, Luis A AU - Conde, Manuel AU - Aldana, Josefa M AU - Torres, Maria-Jose AU - Fernandez-Cuenca, Felipe AU - Garnacho-Montero, Jose AU - Cisneros, Jose M AU - Ortiz, Carlos AU - Pachon, Jeronimo AU - Aznar, Javier AD - Preventive Medicine and Public Health Service, the Clinical Microbiology Service, the Intensive Care Service, and the Infectious Diseases Service, Virgen del Rocio University Hospitals, and the Departments of Preventive Medicine, Microbiology, and Medicine, the University of Seville, Spain., raquel.valencia.sspa@juntadeandalucia.es Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 257 EP - 263 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 30 IS - 3 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Epidemics KW - Quinolones KW - Decontamination KW - Antibiotics KW - Infection KW - Colistin KW - Colonization KW - Acinetobacter baumannii KW - Intensive care units KW - Glycopeptides KW - Risk factors KW - Environmental surveys KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20331786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Nosocomial+Outbreak+of+Infection+With+Pan-Drug-Resistant+Acinetobacter+baumannii+in+a+Tertiary+Care+University+Hospital&rft.au=Valencia%2C+Raquel%3BArroyo%2C+Luis+A%3BConde%2C+Manuel%3BAldana%2C+Josefa+M%3BTorres%2C+Maria-Jose%3BFernandez-Cuenca%2C+Felipe%3BGarnacho-Montero%2C+Jose%3BCisneros%2C+Jose+M%3BOrtiz%2C+Carlos%3BPachon%2C+Jeronimo%3BAznar%2C+Javier&rft.aulast=Valencia&rft.aufirst=Raquel&rft.date=2009-03-01&rft.volume=30&rft.issue=3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F595977 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Epidemics; Quinolones; Decontamination; Antibiotics; Infection; Colistin; Colonization; Glycopeptides; Intensive care units; Risk factors; Hospitals; Environmental surveys; Acinetobacter baumannii DO - http://dx.doi.org/10.1086/595977 ER - TY - RPRT T1 - Approaches to Safe Nanotechnology Managing the Health and Safety Concerns Associated with Engineered Nanomaterials AN - 20183639; 10308238 AB - This document reviews what is currently known about nanoparticle toxicity, process emissions and exposure assessment, engineering controls, and personal protective equipment. This updated version of the document incorporates some of the latest results of NIOSH research, but it is only a starting point. The document serves a dual purpose: it is a summary of NIOSH's current thinking and interim recommendations; and it is a request from NIOSH to occupational safety and health practitioners, researchers, product innovators and manufacturers, employers, workers, interest group members, and the general public to exchange information that will ensure that no worker suffers material impairment of safety or health as nanotechnology develops. JF - Approaches to Safe Nanotechnology Managing the Health and Safety Concerns Associated with Engineered Nanomaterials. [np]. Mar 2009. AU - Anonymous Y1 - 2009/03// PY - 2009 DA - Mar 2009 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Occupational safety KW - interest groups KW - Toxicity KW - Protective equipment KW - safety engineering KW - Reviews KW - Emissions KW - Occupational exposure KW - nanotechnology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20183639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Approaches+to+Safe+Nanotechnology+Managing+the+Health+and+Safety+Concerns+Associated+with+Engineered+Nanomaterials&rft.title=Approaches+to+Safe+Nanotechnology+Managing+the+Health+and+Safety+Concerns+Associated+with+Engineered+Nanomaterials&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - The soluble nickel component of residual oil fly ash alters pulmonary host defense in rats AN - 20176249; 10266644 AB - The soluble metal fraction of residual oil fly ash (ROFA) has been shown to increase the susceptibility to infection in animal models. The goal of this study was to determine which of the primary soluble metals or metal combinations in ROFA were responsible for the increased infectivity. The soluble fraction of ROFA contained Ni, Fe, Al, and Zn. On Day 0, Sprague-Dawley rats were intratracheally (IT) instilled with NiCl2 (55.7 mg/rat), FeSO4 (32.7 mg/rat), Al3(SO4)2 (46.6 mg/rat), or ZnCl2 (8.69 mg/rat), or a combination of all the metals (Total Mixture). In a separate experiment, rats were instilled with metal mixtures, including the total mixture, and mixtures without Fe (Mix - No Fe), Ni (Mix - No Ni), Al (Mix - No Al), or Zn (Mix - No Zn). At Day 3, rats were instilled with 5 X 104 Listeria monocytogenes. At Days 6, 8 and 10, left lungs were removed to assess bacterial clearance. Bronchoalveolar lavage (BAL) was performed on right lungs on Day 3, before infection, and on Days 6, 8 and 10 to assess lung injury and cellular activity. Prior to infection, soluble Ni and mixtures containing Ni significantly increased lung injury, inflammation, and oxidative damage to a comparable degree when compared to control. Post-infection, rats pre-treated with soluble Ni, alone or in a metal mixture, had increased bacterial lung burden on Day 6, and body weight decreased in the soluble Ni, Mix - No Fe, and Mix - No Al groups post-infection, indicating Fe and Al may act antagonistically to Ni. Ni alone and in metal mixtures increased reactive oxidants in the lung and appeared to be the most important factor in suppressing T-cell activity post-infection. Soluble Ni is likely the primary metal involved in the increased susceptibility to infection observed in rats exposed to the soluble metals of ROFA. JF - Journal of Immunotoxicology AU - Roberts, Jenny R AU - Young, Shih-Houng AU - Castranova, Vincent AU - Antonini, James M AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and West Virginia University, Morgantown, West Virginia, USA Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 49 EP - 61 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 6 IS - 1 SN - 1547-691X, 1547-691X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Immunology Abstracts KW - Listeria monocytogenes KW - Metals KW - Injuries KW - Heavy metals KW - Nickel KW - Animal models KW - Fly ash KW - Infection KW - Alveoli KW - Inflammation KW - Oil KW - Infectivity KW - Bronchus KW - Body weight KW - Lung KW - Zinc KW - Lymphocytes T KW - Immune response KW - Oxidants KW - J 02410:Animal Diseases KW - A 01490:Miscellaneous KW - X 24360:Metals KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20176249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunotoxicology&rft.atitle=The+soluble+nickel+component+of+residual+oil+fly+ash+alters+pulmonary+host+defense+in+rats&rft.au=Roberts%2C+Jenny+R%3BYoung%2C+Shih-Houng%3BCastranova%2C+Vincent%3BAntonini%2C+James+M&rft.aulast=Roberts&rft.aufirst=Jenny&rft.date=2009-03-01&rft.volume=6&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunotoxicology&rft.issn=1547691X&rft_id=info:doi/10.1080%2F15476910802630379 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Metals; Injuries; Heavy metals; Nickel; Animal models; Fly ash; Infection; Alveoli; Inflammation; Oil; Infectivity; Body weight; Bronchus; Lung; Zinc; Lymphocytes T; Immune response; Oxidants; Listeria monocytogenes DO - http://dx.doi.org/10.1080/15476910802630379 ER - TY - JOUR T1 - MMRM vs. LOCF: A Comprehensive Comparison Based on Simulation Study and 25 NDA Datasets AN - 20067780; 10070211 AB - In recent years, the use of the last observation carried forward (LOCF) approach in imputing missing data in clinical trials has been greatly criticized, and several likelihood-based modeling approaches are proposed to analyze such incomplete data. One of the proposed likelihood-based methods is the Mixed-Effect Model Repeated Measure (MMRM) model. To compare the performance of LOCF and MMRM approaches in analyzing incomplete data, two extensive simulation studies are conducted, and the empirical bias and Type I error rates associated with estimators and tests of treatment effects under three missing data paradigms are evaluated. The simulation studies demonstrate that LOCF analysis can lead to substantial biases in estimators of treatment effects and can greatly inflate Type I error rates of the statistical tests, whereas MMRM analysis on the available data leads to estimators with comparatively small bias, and controls Type I error rates at a nominal level in the presence of missing completely at random (MCAR) or missing at random (MAR) and some possibility of missing not at random (MNAR) data. In a sensitivity analysis of 48 clinical trial datasets obtained from 25 New Drug Applications (NDA) submissions of neurological and psychiatric drug products, MMRM analysis appears to be a superior approach in controlling Type I error rates and minimizing biases, as compared to LOCF ANCOVA analysis. In the exploratory analyses of the datasets, no clear evidence of the presence of MNAR missingness is found. JF - Journal of Biopharmaceutical Statistics AU - Siddiqui, Ohidul AU - Hung, H M James AU - O'Neill, Robert AD - Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 227 EP - 246 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 19 IS - 2 SN - 1054-3406, 1054-3406 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Statistical analysis KW - Pharmaceuticals KW - Drugs KW - Clinical trials KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20067780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biopharmaceutical+Statistics&rft.atitle=MMRM+vs.+LOCF%3A+A+Comprehensive+Comparison+Based+on+Simulation+Study+and+25+NDA+Datasets&rft.au=Siddiqui%2C+Ohidul%3BHung%2C+H+M+James%3BO%27Neill%2C+Robert&rft.aulast=Siddiqui&rft.aufirst=Ohidul&rft.date=2009-03-01&rft.volume=19&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biopharmaceutical+Statistics&rft.issn=10543406&rft_id=info:doi/10.1080%2F10543400802609797 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Statistical analysis; Clinical trials; Drugs; Pharmaceuticals DO - http://dx.doi.org/10.1080/10543400802609797 ER - TY - JOUR T1 - Device safety and effectiveness in the pediatric population: a US FDA perspective AN - 1019647423; 16460655 AB - The US FDA recognizes that there are many challenges to ensuring that medical devices are used responsibly and safely in the pediatric population. Education plays a key role, and manufacturers and healthcare providers must be informed of medical device issues unique to the pediatric population. Healthcare workers and device manufacturers must recognize that adverse events may differ between the adult and pediatric population and among pediatric subpopulations. Risk mitigation may also differ, and heightened awareness will reduce the potential for adverse events and promote the safe use of medical devices in children. JF - Expert Review of Medical Devices AU - Samuels-Reid, Joy AU - Cope, Judith U AU - Morrison, Audrey E AD - Division of Anesthesiology, General Hospital; and, Infection Control and Dental Devices; and, Center for Devices and Radiological Health, Office of Device Evaluation, FDA, 9200 Corporate Blvd. Rockville, MD 20857, USA., joy.samuels-reid@fda.hhs.gov Y1 - 2009/03// PY - 2009 DA - Mar 2009 SP - 131 EP - 135 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 6 IS - 2 SN - 1743-4440, 1743-4440 KW - Health & Safety Science Abstracts KW - children KW - device classification KW - diagnostic test KW - human factor KW - implanted device KW - medical device KW - pediatric KW - safety KW - US FDA KW - USA KW - Education KW - Mitigation KW - Reviews KW - Subpopulations KW - medical equipment KW - FDA KW - Children KW - Side effects KW - Medical personnel KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1019647423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Review+of+Medical+Devices&rft.atitle=Device+safety+and+effectiveness+in+the+pediatric+population%3A+a+US+FDA+perspective&rft.au=Samuels-Reid%2C+Joy%3BCope%2C+Judith+U%3BMorrison%2C+Audrey+E&rft.aulast=Samuels-Reid&rft.aufirst=Joy&rft.date=2009-03-01&rft.volume=6&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Expert+Review+of+Medical+Devices&rft.issn=17434440&rft_id=info:doi/10.1586%2F17434440.6.2.131 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Number of references - 8 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mitigation; Education; Subpopulations; Reviews; medical equipment; FDA; Children; Medical personnel; Side effects; USA DO - http://dx.doi.org/10.1586/17434440.6.2.131 ER - TY - CPAPER T1 - Metadata for Consumers T2 - Second International Symposium on Technologies for Digital Photo Fulfillment AN - 41897874; 5096385 JF - Second International Symposium on Technologies for Digital Photo Fulfillment AU - Barda, Jean Y1 - 2009/02/28/ PY - 2009 DA - 2009 Feb 28 KW - Consumers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41897874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+public+health&rft.atitle=Gene+by+environment+interaction+in+asthma.&rft.au=London%2C+Stephanie+J%3BRomieu%2C+Isabelle&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2009-01-01&rft.volume=30&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+public+health&rft.issn=1545-2093&rft_id=info:doi/10.1146%2Fannurev.pharmtox.48.113006.094928 L2 - http://www.imaging.org/conferences/tdpf2009/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. AN - 66966428; 19066394 AB - Organochlorine exposure was linked to non-Hodgkin lymphoma (NHL) risk. To determine whether this relation is modified by immune gene variation, we genotyped 61 polymorphisms in 36 immune genes in 1172 NHL cases and 982 controls from the National Cancer Institute-Surveillance, Epidemiology, and End Results (NCI-SEER) study. We examined 3 exposures with elevated risk in this study: PCB180 (plasma, dust measurements), the toxic equivalency quotient (an integrated functional measure of several organochlorines) in plasma, and alpha-chlordane (dust measurements, self-reported termiticide use). Plasma (100 cases, 100 controls) and dust (682 cases, 513 controls) levels were treated as natural log-transformed continuous variables. Unconditional logistic regression was used to calculate beta coefficients and odds ratios, stratified by genotype. Associations between all 3 exposures and NHL risk were limited to the same genotypes for IFNG (C-1615T) TT and IL4 (5'-UTR, Ex1-168C>T) CC. Associations between PCB180 in plasma and dust and NHL risk were limited to the same genotypes for IL16 (3'-UTR, Ex22+871A>G) AA, IL8 (T-251A) TT, and IL10 (A-1082G) AG/GG. This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL. JF - Blood AU - Colt, Joanne S AU - Rothman, Nathaniel AU - Severson, Richard K AU - Hartge, Patricia AU - Cerhan, James R AU - Chatterjee, Nilanjan AU - Cozen, Wendy AU - Morton, Lindsay M AU - De Roos, Anneclaire J AU - Davis, Scott AU - Chanock, Stephen AU - Wang, Sophia S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7240, USA. coltj@mail.nih.gov Y1 - 2009/02/26/ PY - 2009 DA - 2009 Feb 26 SP - 1899 EP - 1905 VL - 113 IS - 9 KW - Hydrocarbons, Chlorinated KW - 0 KW - Interleukins KW - PCB 180 KW - 35065-29-3 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Abridged Index Medicus KW - Index Medicus KW - Genotype KW - Young Adult KW - Polymorphism, Single Nucleotide KW - Risk Factors KW - Polychlorinated Biphenyls -- toxicity KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Interleukins -- genetics KW - Female KW - Lymphoma, Non-Hodgkin -- genetics KW - Hydrocarbons, Chlorinated -- toxicity KW - Lymphoma, Non-Hodgkin -- etiology KW - Immunity, Innate -- genetics KW - Lymphoma, Non-Hodgkin -- immunology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66966428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Organochlorine+exposure%2C+immune+gene+variation%2C+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Colt%2C+Joanne+S%3BRothman%2C+Nathaniel%3BSeverson%2C+Richard+K%3BHartge%2C+Patricia%3BCerhan%2C+James+R%3BChatterjee%2C+Nilanjan%3BCozen%2C+Wendy%3BMorton%2C+Lindsay+M%3BDe+Roos%2C+Anneclaire+J%3BDavis%2C+Scott%3BChanock%2C+Stephen%3BWang%2C+Sophia+S&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2009-02-26&rft.volume=113&rft.issue=9&rft.spage=1899&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2008-04-153858 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-10 N1 - Date created - 2009-02-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2007 Jun 1;67(11):5545-52 [17545638] Lancet. 1997 Jul 26;350(9073):240-4 [9242800] Cancer Causes Control. 2007 Oct;18(8):821-31 [17588155] Blood. 2007 Dec 15;110(13):4455-63 [17827388] Am J Epidemiol. 1997 Jun 15;145(12):1061-75 [9199536] Environ Health Perspect. 2000 Dec;108(12):1203-7 [11133402] Leuk Lymphoma. 2001 Aug;42(4):619-29 [11697490] Environ Health Perspect. 2002 Jun;110(6):595-600 [12055051] Leuk Lymphoma. 2002 Jun;43(6):1203-10 [12152987] Food Chem Toxicol. 2003 Jan;41(1):107-18 [12453735] Am J Hum Genet. 2003 Jun;72(6):1505-14 [12748907] Clin Immunol. 2003 Nov;109(2):119-29 [14597210] IARC Monogr Eval Carcinog Risks Hum. 1997;69:1-631 [9379504] Environ Health Perspect. 1998 Dec;106(12):775-92 [9831538] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] Epidemiology. 2005 Jul;16(4):516-25 [15951670] Cancer Res. 2005 Dec 1;65(23):11214-26 [16322272] Lancet Oncol. 2006 Jan;7(1):27-38 [16389181] Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):251-7 [16492912] Blood. 2006 May 15;107(10):4101-8 [16449530] Cancer Res. 2006 Oct 1;66(19):9771-80 [17018637] Mol Hum Reprod. 2007 Feb;13(2):135-40 [17178764] Chemosphere. 2007 Apr;67(9):S393-8 [17222440] Carcinogenesis. 2007 Mar;28(3):704-12 [17056605] Cancer Res. 2007 May 15;67(10):5042-54 [17510437] J Expo Anal Environ Epidemiol. 2004 Jan;14(1):74-83 [14726946] Environ Health Perspect. 2004 Jun;112(8):854-61 [15175172] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1415-21 [15342441] N Engl J Med. 1991 Jan 24;324(4):212-8 [1985242] Am J Ind Med. 1990;18(6):665-73 [2264565] Arch Environ Health. 1992 Jul-Aug;47(4):295-301 [1497384] Epidemiology. 1993 Sep;4(5):398-406 [8399687] Blood. 1994 Sep 1;84(5):1361-92 [8068936] Exp Clin Immunogenet. 1994;11(2-3):149-62 [7826664] Environ Health Perspect. 1995 Mar;103 Suppl 2:135-42 [7614935] Pediatr Res. 1995 Sep;38(3):404-10 [7494667] Am J Ophthalmol. 1995 Nov;120(5):671-3 [7485372] Eur J Immunogenet. 1997 Feb;24(1):1-8 [9043871] Haematologica. 2007 Jul;92(7):960-9 [17606447] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2008-04-153858 ER - TY - JOUR T1 - Evaluation of Macaca mulatta as a model for genotoxicity studies AN - 20302260; 8898854 AB - We have investigated the use of peripheral blood from the nonhuman primate (NHP) rhesus monkey (Macaca mulatta) as a model system for mutation detection. The rhesus monkey is metabolically closer to humans than most common laboratory animals, and therefore may be a relevant model for hazard identification and human risk assessment. To validate the model, conditions were determined for in vitro selection and expansion of 6-thioguanine-resistant (6-TGr) HPRT mutant and proaerolysin-resistant (ProAERr) PIG-A mutant lymphocytes from peripheral blood obtained by routine venipuncture. Also, flow cytometric methods were developed for the rapid detection of PIG-A mutant erythrocytes. The flow cytometric analysis of PIG-A mutant erythrocytes was based on enumerating cells deficient in surface markers attached to the cellular membrane via glycosylphosphatidyl inositol (GPI) anchors. Mutant cells were enumerated over an extended period of time in peripheral blood of male monkeys receiving daily doses of the electrolyte replenisher Prang(TM) (a common carrier for oral delivery of drugs in NHPs), and in the blood of one male monkey treated with a single i.p. dose of 50mg/kg of N-ethyl-N-nitrosourea at 2 years of age and another similar injection at approximately 3.5 years of age. The spontaneous PIG-A and HPRT T-cell mutant frequency (MF) was low in animals receiving Prang (0-8x10 super(-) super(6)), and treatment with ENU resulted in a clearly detectable increase in the frequency of ProAERr and 6-TGr lymphocytes (up to ~28x10 super(-) super(6) and ~30x10 super(-) super(6), respectively). Also, the ENU-treated animal had higher frequency of GPI-deficient erythrocytes (46.5x10 super(-) super(6) in the treated animal vs. 7.8+/-4.2x10 super(-) super(6) in control animals). Our results indicate that the rhesus monkey can be a valuable model for the identification of agents that may impact upon human health as mutagens and that the PIG-A gene can be a useful target for detection of mutation in both white and red blood cells. JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis AU - Dobrovolsky, V N AU - Shaddock, J G AU - Mittelstaedt, R A AU - Manjanatha, M G AU - Miura, D AU - Uchikawa, M AU - Mattison AU - Morris, S M AD - National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, 3900 NCTR Rd., HFT-120, Jefferson, AR 72079, USA, vasily.dobrovolsky@fda.hhs.gov Y1 - 2009/02/19/ PY - 2009 DA - 2009 Feb 19 SP - 21 EP - 28 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 673 IS - 1 SN - 1383-5718, 1383-5718 KW - Genetics Abstracts; Toxicology Abstracts KW - Risk assessment KW - Mutagens KW - Drug delivery KW - Age KW - Erythrocytes KW - Genotoxicity KW - Laboratory animals KW - Mutant frequency KW - Peripheral blood KW - Lymphocytes KW - Primates KW - Mutagenesis KW - Flow cytometry KW - Lymphocytes T KW - Ethyl nitrosourea KW - Macaca mulatta KW - Glycosylphosphatidylinositol KW - Mutation KW - Surface markers KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20302260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Evaluation+of+Macaca+mulatta+as+a+model+for+genotoxicity+studies&rft.au=Dobrovolsky%2C+V+N%3BShaddock%2C+J+G%3BMittelstaedt%2C+R+A%3BManjanatha%2C+M+G%3BMiura%2C+D%3BUchikawa%2C+M%3BMattison%3BMorris%2C+S+M&rft.aulast=Dobrovolsky&rft.aufirst=V&rft.date=2009-02-19&rft.volume=673&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2008.11.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Drug delivery; Mutagens; Age; Genotoxicity; Erythrocytes; Laboratory animals; Peripheral blood; Mutant frequency; Lymphocytes; Mutagenesis; Flow cytometry; Lymphocytes T; Ethyl nitrosourea; Glycosylphosphatidylinositol; Mutation; Surface markers; Macaca mulatta; Primates DO - http://dx.doi.org/10.1016/j.mrgentox.2008.11.006 ER - TY - JOUR T1 - The genetic toxicology of methylphenidate hydrochloride in non-human primates AN - 20266882; 8898862 AB - The studies presented in this work were designed to evaluate the genetic toxicity of methylphenidate hydrochloride (MPH) in non-human primates (NHP) using a long-term, chronic dosing regimen. Thus, approximately two-year old, male rhesus monkeys of Indian origin were orally exposed to MPH diluted in the electrolyte replenisher, Prang super(()R), five days per week over a 20-month period. There were 10 animals per dose group and the doses were (1) control, Prang only, (2) low, 0.15mg/kg of MPH twice per day increased to 2.5mg/kg twice per day and (3) high, 1.5mg/kg of MPH twice per day increased to 12.5mg/kg twice per day. Blood samples were obtained from each animal to determine the base-line serum levels of MPH and the major metabolite of MPH in NHP, ritalinic acid (RA). In addition, the base-line frequency of micronucleated erythrocytes (MN-RETs) by flow cytometry, HPRT mutants by a lymphocyte cloning assay, and chromosome aberrations by FISH painting were determined from peripheral blood samples. Once dosing began, the serum levels of MPH and its major metabolite, RA, were determined monthly. The MN-RET frequency and health parameters (CBC, serum chemistries) were also determined monthly. HPRT mutant and chromosome aberration frequencies were measured every three months. CBC values and serum chemistries, with the exception of alanine amino transferase, were within normal limits over the course of drug exposure. The final plasma levels of MPH were similar to those produced by the pediatric dose of 0.3kg/ml. No significant increases in the frequencies of MN-RETs, HPRT mutants, or chromosome aberrations were detected in the treated animals compared to the control animals over the 20-month exposure period. JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis AU - Morris, S M AU - Dobrovolsky, V N AU - Shaddock, J G AU - Mittelstaedt, R A AU - Bishop, ME AU - Manjanatha, M G AU - Shelton, S D AU - Doerge AU - Twaddle, N C AU - Chen, J J AU - Lin, C J AU - Paule, M G AU - Slikker, W AU - Hotchkiss, CE AU - Petibone, D AU - Tucker, J D AU - Mattison AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States, suzanne.morris@fda.hhs.gov Y1 - 2009/02/19/ PY - 2009 DA - 2009 Feb 19 SP - 59 EP - 66 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 673 IS - 1 SN - 1383-5718, 1383-5718 KW - Genetics Abstracts; Toxicology Abstracts KW - Alanine KW - Pediatrics KW - Erythrocytes KW - Methylphenidate KW - Peripheral blood KW - Metabolites KW - Toxicity KW - Lymphocytes KW - Primates KW - Mutagenesis KW - Flow cytometry KW - Serum levels KW - Plasma levels KW - Macaca mulatta KW - Chromosome aberrations KW - Drugs KW - Fluorescence in situ hybridization KW - X 24310:Pharmaceuticals KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20266882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=The+genetic+toxicology+of+methylphenidate+hydrochloride+in+non-human+primates&rft.au=Morris%2C+S+M%3BDobrovolsky%2C+V+N%3BShaddock%2C+J+G%3BMittelstaedt%2C+R+A%3BBishop%2C+ME%3BManjanatha%2C+M+G%3BShelton%2C+S+D%3BDoerge%3BTwaddle%2C+N+C%3BChen%2C+J+J%3BLin%2C+C+J%3BPaule%2C+M+G%3BSlikker%2C+W%3BHotchkiss%2C+CE%3BPetibone%2C+D%3BTucker%2C+J+D%3BMattison&rft.aulast=Morris&rft.aufirst=S&rft.date=2009-02-19&rft.volume=673&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2008.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Alanine; Pediatrics; Erythrocytes; Methylphenidate; Metabolites; Peripheral blood; Lymphocytes; Toxicity; Mutagenesis; Serum levels; Flow cytometry; Plasma levels; Drugs; Chromosome aberrations; Fluorescence in situ hybridization; Macaca mulatta; Primates DO - http://dx.doi.org/10.1016/j.mrgentox.2008.12.001 ER - TY - JOUR T1 - Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies. AN - 66901766; 19103213 AB - Drug-induced liver injury has been associated with the generation of reactive metabolites, which are primarily detoxified via glutathione conjugation. In this study, it was hypothesized that molecules involved in the synthesis of glutathione would be diminished to replenish the glutathione depleted through conjugation reactions. Since S-adenosylmethionine (SAMe) is the primary source of the sulfur atom in glutathione, UPLC/MS and NMR were used to evaluate metabolites involved with the transulfuration pathway in urine samples collected during studies of eight liver toxic compounds in Sprague-Dawley rats. Urinary levels of creatine were increased on day 1 or day 2 in 8 high dose liver toxicity studies. Taurine concentration in urine was increased in only 3 of 8 liver toxicity studies while SAMe was found to be reduced in 4 of 5 liver toxicity studies. To further validate the results from the metabonomic studies, microarray data from rat liver samples following treatment with acetaminophen was obtained from the Gene Expression Omnibus (GEO) database. Some genes involved in the trans-sulfuration pathway, including guanidinoacetate N-methyltransferase, glycine N-methyltransferase, betaine-homocysteine methyltransferase and cysteine dioxygenase were found to be significantly decreased while methionine adenosyl transferase II, alpha increased at 24 h post-dosing, which is consistent with the SAMe and creatine findings. The metabolic and transcriptomic results show that the trans-sulfuration pathway from SAMe to glutathione was disturbed due to the administration of heptatotoxicants. JF - Toxicology and applied pharmacology AU - Schnackenberg, Laura K AU - Chen, Minjun AU - Sun, Jinchun AU - Holland, Ricky D AU - Dragan, Yvonne AU - Tong, Weida AU - Welsh, William AU - Beger, Richard D AD - Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, FDA, Jefferson, AR 72079, USA. richard.beger@fda.hhs.gov Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 SP - 25 EP - 32 VL - 235 IS - 1 KW - adenosyl-methionine 1,4-butanedisulfonate KW - 0 KW - Taurine KW - 1EQV5MLY3D KW - S-Adenosylmethionine KW - 7LP2MPO46S KW - Glutathione KW - GAN16C9B8O KW - Creatine KW - MU72812GK0 KW - Index Medicus KW - Creatine -- metabolism KW - S-Adenosylmethionine -- analogs & derivatives KW - Animals KW - Comet Assay KW - Taurine -- metabolism KW - Glutathione -- metabolism KW - Creatine -- urine KW - Taurine -- urine KW - S-Adenosylmethionine -- urine KW - Rats KW - Gene Expression Profiling KW - Rats, Sprague-Dawley KW - S-Adenosylmethionine -- metabolism KW - Male KW - Liver -- enzymology KW - Liver -- drug effects KW - Drug-Related Side Effects and Adverse Reactions KW - Chemical and Drug Induced Liver Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66901766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Evaluations+of+the+trans-sulfuration+pathway+in+multiple+liver+toxicity+studies.&rft.au=Schnackenberg%2C+Laura+K%3BChen%2C+Minjun%3BSun%2C+Jinchun%3BHolland%2C+Ricky+D%3BDragan%2C+Yvonne%3BTong%2C+Weida%3BWelsh%2C+William%3BBeger%2C+Richard+D&rft.aulast=Schnackenberg&rft.aufirst=Laura&rft.date=2009-02-15&rft.volume=235&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2008.11.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2008.11.015 ER - TY - JOUR T1 - Adipokine genes and prostate cancer risk. AN - 66746238; 19035456 AB - Adiposity and adipocyte-derived cytokines have been implicated in prostate carcinogenesis. However, the relationship of adipokine gene variants with prostate cancer risk has not been thoroughly investigated. We therefore examined common variants of the IL6, LEP, LEPR, TNF and ADIPOQ genes in relation to prostate cancer in a case-control study nested within a large cohort of Finnish men. The study sample consisted of 1,053 cases of prostate cancer, diagnosed over an average 11 years of follow up, and 1,053 controls matched to the cases on age, intervention group and date of baseline blood draw. Logistic regression was used to model the relative odds of prostate cancer. We also examined genotypes in relation to serum insulin, IGF-1 and IGF-1:IGFBP-3 among 196 controls. Variant alleles at three loci (-14858A>G, -13973A>C, -13736C>A) in a potential regulatory region of the LEP gene conferred a statistically significant 20% reduced risk of prostate cancer. For example, at the -14858A>G locus, heterozygotes and homozygotes for the A allele had an odds ratio (OR) of prostate cancer of 0.76 [95% confidence interval (CI) 0.62, 0.93] and 0.79 (95% CI 0.60, 1.04), respectively. At 13288G>A, relative to the GG genotype, the AA genotype was associated with a suggestive increased risk of prostate cancer (OR = 1.29; 95% CI 0.99,1.67; p(trend) = 0.05). Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis. JF - International journal of cancer AU - Moore, Steven C AU - Leitzmann, Michael F AU - Albanes, Demetrius AU - Weinstein, Stephanie J AU - Snyder, Kirk AU - Virtamo, Jarmo AU - Ahn, Jiyoung AU - Mayne, Susan T AU - Yu, Herbert AU - Peters, Ulrike AU - Gunter, Marc J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. moorest@mail.nih.gov Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 SP - 869 EP - 876 VL - 124 IS - 4 KW - Adipokines KW - 0 KW - Adiponectin KW - Cytokines KW - Insulin KW - Interleukin-6 KW - Leptin KW - Receptors, Leptin KW - Tumor Necrosis Factor-alpha KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Index Medicus KW - Risk KW - Finland KW - Humans KW - Cohort Studies KW - Case-Control Studies KW - Insulin-Like Growth Factor I -- metabolism KW - Insulin -- metabolism KW - Aged KW - Middle Aged KW - Cytokines -- metabolism KW - Linkage Disequilibrium KW - Male KW - Prostatic Neoplasms -- metabolism KW - Prostatic Neoplasms -- pathology KW - Prostatic Neoplasms -- epidemiology KW - Adiponectin -- metabolism KW - Interleukin-6 -- metabolism KW - Receptors, Leptin -- metabolism KW - Adipokines -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Leptin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66746238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Adipokine+genes+and+prostate+cancer+risk.&rft.au=Moore%2C+Steven+C%3BLeitzmann%2C+Michael+F%3BAlbanes%2C+Demetrius%3BWeinstein%2C+Stephanie+J%3BSnyder%2C+Kirk%3BVirtamo%2C+Jarmo%3BAhn%2C+Jiyoung%3BMayne%2C+Susan+T%3BYu%2C+Herbert%3BPeters%2C+Ulrike%3BGunter%2C+Marc+J&rft.aulast=Moore&rft.aufirst=Steven&rft.date=2009-02-15&rft.volume=55&rft.issue=&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Advances+in+food+and+nutrition+research&rft.issn=10434526&rft_id=info:doi/10.1016%2FS1043-4526%2808%2900403-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-14 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1998 Mar 26;392(6674):398-401 [9537324] Ann Hum Genet. 1999 May;63(Pt 3):227-34 [10738535] Science. 1998 Sep 11;281(5383):1683-6 [9733517] Comp Biochem Physiol A Mol Integr Physiol. 2000 Mar;125(3):285-98 [10794958] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514] Prostate. 2001 Jan 1;46(1):62-7 [11170133] J Clin Endocrinol Metab. 2001 Mar;86(3):1341-5 [11238530] Ann Hum Genet. 2000 Sep;64(Pt 5):391-4 [11281277] J Natl Cancer Inst. 2001 May 16;93(10):783-9 [11353789] Atherosclerosis. 2001 Aug;157(2):495-503 [11472752] Cancer Res. 2002 Jun 15;62(12):3369-72 [12067976] Science. 2002 Jun 21;296(5576):2225-9 [12029063] Horm Metab Res. 2002 Jul;34(7):355-9 [12189581] Acta Oncol. 2002;41(4):381-8 [12234031] Int J Cancer. 2003 Jan 10;103(2):241-5 [12455039] Annu Rev Med. 2003;54:131-52 [12525670] Cancer Epidemiol Biomarkers Prev. 2003 May;12(5):474-5 [12750247] BJU Int. 2003 Jul;92(1):109-12 [12823393] Cancer Res. 2003 Jul 15;63(14):3991-4 [12873996] Eur J Cancer Prev. 2003 Aug;12(4):309-15 [12883384] Endocrinology. 2003 Sep;144(9):3765-73 [12933646] Med Sci Sports Exerc. 2003 Oct;35(10):1662-9 [14523302] Prostate. 2004 May 15;59(3):268-74 [15042602] Urol Int. 2004;73(1):41-6 [15263792] Am J Hum Genet. 2004 Aug;75(2):220-30 [15197684] Eur J Cancer Prev. 2004 Oct;13(5):359-68 [15452447] Eur J Cancer Prev. 1992 Apr;1(3):239-45 [1467769] Nature. 1994 Dec 1;372(6505):425-32 [7984236] J Natl Cancer Inst. 1996 Nov 6;88(21):1560-70 [8901854] J Clin Endocrinol Metab. 1997 Apr;82(4):1066-70 [9100574] FASEB J. 1998 Jan;12(1):57-65 [9438411] Diabetes. 1998 Mar;47(3):487-9 [9519759] Circ Res. 1998 Nov 16;83(10):1059-66 [9815153] J Clin Endocrinol Metab. 1998 Dec;83(12):4382-5 [9851781] J Androl. 1999 Jul-Aug;20(4):487-91 [10452592] Urology. 2005 Jun;65(6):1168-72 [15922427] Vitam Horm. 2005;71:373-404 [16112275] Prostate Cancer Prostatic Dis. 2006;9(1):19-24 [16344847] Obesity (Silver Spring). 2006 Feb;14(2):183-7 [16571841] Cancer Res. 2006 Apr 15;66(8):4525-30 [16618781] Cancer J. 2006 May-Jun;12(3):201-6 [16803678] Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1331-5 [16835332] Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):308-13 [17301264] Nat Genet. 2007 May;39(5):645-9 [17401363] Front Biosci. 2007;12:3436-60 [17485312] Eur Urol. 2007 Jul;52(1):46-53 [17399889] Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1291-3 [17548700] Nature. 2007 Oct 18;449(7164):851-61 [17943122] PLoS Med. 2007 Dec;4(12):e352 [18076282] Nat Genet. 2008 Mar;40(3):310-5 [18264096] Int J Obes Relat Metab Disord. 1998 Mar;22(3):200-5 [9539186] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.24043 ER - TY - JOUR T1 - Correlation analysis of external RNA controls reveals its utility for assessment of microarray assay AN - 20345841; 9011106 AB - Quality control of a microarray experiment has become an important issue for both research and regulation. External RNA controls (ERCs), which can be either added to the total RNA level (tERCs) or introduced right before hybridization (cERCs), are designed and recommended by commercial microarray platforms for assessment of performance of a microarray experiment. However, the utility of ERCs has not been fully realized mainly due to the lack of sufficient data resources. The US Food and Drug Administration (FDA)-led community-wide Microarray Quality Control (MAQC) study generates a large amount of microarray data with implementation of ERCs across several commercial microarray platforms. The utility of ERCs in quality control by assessing the ERCs' concentration -response behavior was investigated in the MAQC study. In this work, an ERC-based correlation analysis was conducted to assess the quality of a microarray experiment. We found that the pairwise correlations of tERCs are sample independent, indicating that the array data obtained from different biological samples can be treated as technical replicates in analysis of tERCs. Consequently, the commonly used quality control method of applying correlation analysis on technical replicates can be adopted for assessing array performance based on different biological samples using tERCs. The proposed approach is sensitive to identifying outlying assays and is not dependent on the choice of normalization method. JF - Analytical Biochemistry AU - Fan, Xiaohui AU - Fang, Hong AU - Hong, Huixiao AU - Perkins, Roger AU - Shi, Leming AU - Tong, Weida AD - National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA, weida.tong@fda.hhs.gov Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 SP - 203 EP - 207 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 385 IS - 2 SN - 0003-2697, 0003-2697 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - DNA microarray KW - Quality control KW - External RNA controls KW - MAQC KW - Outlier identification KW - Data processing KW - RNA KW - Correlation analysis KW - N 14810:Methods KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20345841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=Correlation+analysis+of+external+RNA+controls+reveals+its+utility+for+assessment+of+microarray+assay&rft.au=Fan%2C+Xiaohui%3BFang%2C+Hong%3BHong%2C+Huixiao%3BPerkins%2C+Roger%3BShi%2C+Leming%3BTong%2C+Weida&rft.aulast=Fan&rft.aufirst=Xiaohui&rft.date=2009-02-15&rft.volume=385&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2008.11.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; RNA; Quality control; Correlation analysis DO - http://dx.doi.org/10.1016/j.ab.2008.11.019 ER - TY - JOUR T1 - The Fine Structure of Neisseria meningitidis Lipooligosaccharide from the M986 Strain and Three of Its Variants AN - 21085374; 11080232 AB - Neisseria meningitidis is a cause of fatal sepsis and epidemic meningitis. A major virulence factor is cell wall lipooligosaccharide (LOS). The M986 strain has been used extensively in immunological and vaccine research. Yet, the LOS repertoire of this strain is not known. Here we have investigated the LOS structures of M986 and three of its variants OP1, OP2-, and OP2+. This strain and its variants present a series of related LOS families that are increasingly truncated in their listed order. The major structural differences are seen in the lacto-N-neotetraose {alpha}-chain. The {gamma}-chain Hep II contains two phosphoethanolamine (PEA) substitutions at C3 and C6/7. These substitutions were seen in all strains except OP2+ where the canonical core Hep II is missing. The PEA disubstitution was present in nearly stoichiometric amounts with only minor amounts of monosubstitution observed, and no glycomers devoid of PEA were seen. This was also the case in LOS with a complete lacto-N-neotetraosyl {alpha}-chain even though previous reports suggested that the presence of an extended {alpha}-chain hinders C3 PEA substitution of Hep II. Approximately 50% of {gamma}-chain GlcNAc was present in its 3-OAc-substituted form. Because Hep II C3 PEA substitution and {gamma}-chain GlcNAc OAc addition have been reported to negatively interact, the co- existence of these two modifications in these strains is unique. The LOS structures of M986 and three of its variants have been determined, which better defines these strains as tools for immunological and vaccine research. JF - Journal of Biological Chemistry AU - Tsai, Chao-Ming AU - Jankowska-Stephens, Ewa AU - Mizanur, Rahman M AU - Cipollo, John F AD - Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892 Y1 - 2009/02/13/ PY - 2009 DA - 2009 Feb 13 SP - 4616 EP - 4625 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 284 IS - 7 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Sepsis KW - Epidemics KW - virulence factors KW - Neisseria meningitidis KW - Vaccines KW - Ultrastructure KW - Lipooligosaccharides KW - Cell walls KW - Meningitis KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21085374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Fine+Structure+of+Neisseria+meningitidis+Lipooligosaccharide+from+the+M986+Strain+and+Three+of+Its+Variants&rft.au=Tsai%2C+Chao-Ming%3BJankowska-Stephens%2C+Ewa%3BMizanur%2C+Rahman+M%3BCipollo%2C+John+F&rft.aulast=Tsai&rft.aufirst=Chao-Ming&rft.date=2009-02-13&rft.volume=284&rft.issue=7&rft.spage=4616&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M808209200 L2 - http://www.jbc.org/cgi/reprint/284/7/4616.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Sepsis; Epidemics; virulence factors; Vaccines; Ultrastructure; Meningitis; Cell walls; Lipooligosaccharides; Neisseria meningitidis DO - http://dx.doi.org/10.1074/jbc.M808209200 ER - TY - CPAPER T1 - Regulatory Frameworks for Nanotechnology Applications in Food: Are They Adequate? T2 - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AN - 41941451; 5108281 JF - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AU - Thurmond, Thane Y1 - 2009/02/12/ PY - 2009 DA - 2009 Feb 12 KW - Nanotechnology KW - Food KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41941451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Age+at+menarche+and+weight+concerns+in+relation+to+smoking+trajectory+and+dependence+among+adolescent+girls+enrolled+in+a+smoking+cessation+trial.&rft.au=Jaszyna-Gasior%2C+Maria%3BSchroeder%2C+Jennifer+R%3BThorner%2C+Elissa+D%3BHeishman%2C+Stephen+J%3BCollins%2C+Charles+C%3BLo%2C+Suzanne%3BMoolchan%2C+Eric+T&rft.aulast=Jaszyna-Gasior&rft.aufirst=Maria&rft.date=2009-01-01&rft.volume=34&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=1873-6327&rft_id=info:doi/10.1016%2Fj.addbeh.2008.08.001 L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=8AA65090- 37AD-4C29-9CF1-9BCD6EFA2210&AKey=82DF1193-261B-4248-AC6B-CACD0186BD6 B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Five-Year Plan for Advancing Alternative Methods T2 - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AN - 41911205; 5107968 JF - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AU - Stokes, William Y1 - 2009/02/12/ PY - 2009 DA - 2009 Feb 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41911205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.atitle=A+Five-Year+Plan+for+Advancing+Alternative+Methods&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2009-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=8AA65090- 37AD-4C29-9CF1-9BCD6EFA2210&AKey=82DF1193-261B-4248-AC6B-CACD0186BD6 B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Challenges for Nanomaterials in Public Health T2 - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AN - 41899600; 5108273 JF - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AU - Alderson, Norris Y1 - 2009/02/12/ PY - 2009 DA - 2009 Feb 12 KW - Public health KW - Nanotechnology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Substance+use+disorder+among+older+adults+in+the+United+States+in+2020&rft.au=Han%2C+Beth%3BGfroerer%2C+Joseph+C%3BColliver%2C+James+D%3BPenne%2C+Michael+A&rft.aulast=Han&rft.aufirst=Beth&rft.date=2009-01-01&rft.volume=104&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02411.x L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=8AA65090- 37AD-4C29-9CF1-9BCD6EFA2210&AKey=82DF1193-261B-4248-AC6B-CACD0186BD6 B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - International Cooperation To Regulate Drug Safety T2 - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AN - 41885500; 5108211 JF - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AU - Woodcock, Janet Y1 - 2009/02/12/ PY - 2009 DA - 2009 Feb 12 KW - Drugs KW - International cooperation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41885500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.atitle=International+Cooperation+To+Regulate+Drug+Safety&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2009-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=8AA65090- 37AD-4C29-9CF1-9BCD6EFA2210&AKey=82DF1193-261B-4248-AC6B-CACD0186BD6 B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The FDA's Approach to Imports T2 - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AN - 41879502; 5107820 JF - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AU - Solomon, Stephen Y1 - 2009/02/12/ PY - 2009 DA - 2009 Feb 12 KW - Imports KW - FDA KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41879502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.atitle=The+FDA%27s+Approach+to+Imports&rft.au=Solomon%2C+Stephen&rft.aulast=Solomon&rft.aufirst=Stephen&rft.date=2009-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=8AA65090- 37AD-4C29-9CF1-9BCD6EFA2210&AKey=82DF1193-261B-4248-AC6B-CACD0186BD6 B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drug Use in Food-Producing Species T2 - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AN - 41870959; 5108242 JF - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AU - Flynn, William Y1 - 2009/02/12/ PY - 2009 DA - 2009 Feb 12 KW - Drug abuse KW - Food KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41870959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.atitle=Drug+Use+in+Food-Producing+Species&rft.au=Flynn%2C+William&rft.aulast=Flynn&rft.aufirst=William&rft.date=2009-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=8AA65090- 37AD-4C29-9CF1-9BCD6EFA2210&AKey=82DF1193-261B-4248-AC6B-CACD0186BD6 B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A task-based evaluation method for x-ray breast imaging systems using variable background phantoms T2 - 2009 Conference on Physics of Medical Imaging (MI101) AN - 41748082; 5010389 JF - 2009 Conference on Physics of Medical Imaging (MI101) AU - Park, Subok AU - Leimbach, Robert AU - Liu, Haimo AU - Kyprianou, Iacovos AU - Jennings, Robert AU - Badano, Aldo AU - Myers, Kyle Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Ionizing radiation KW - Imaging techniques KW - X-rays KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41748082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Physics+of+Medical+Imaging+%28MI101%29&rft.atitle=A+task-based+evaluation+method+for+x-ray+breast+imaging+systems+using+variable+background+phantoms&rft.au=Park%2C+Subok%3BLeimbach%2C+Robert%3BLiu%2C+Haimo%3BKyprianou%2C+Iacovos%3BJennings%2C+Robert%3BBadano%2C+Aldo%3BMyers%2C+Kyle&rft.aulast=Park&rft.aufirst=Subok&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Physics+of+Medical+Imaging+%28MI101%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/Medical-Imaging2009-F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of classifi er performance estimators: a simulation study T2 - 2009 Conference on Image Perception, Observer Performance, and Technology Assessment (MI106) AN - 41739088; 5011641 JF - 2009 Conference on Image Perception, Observer Performance, and Technology Assessment (MI106) AU - Chen, Weijie AU - Wagner, Robert AU - Yousef, Waleed Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Simulation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41739088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI106%29&rft.atitle=Comparison+of+classifi+er+performance+estimators%3A+a+simulation+study&rft.au=Chen%2C+Weijie%3BWagner%2C+Robert%3BYousef%2C+Waleed&rft.aulast=Chen&rft.aufirst=Weijie&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI106%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/Medical-Imaging2009-F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A matched fi lter approach for the analysis of lung nodules in a volumetric CT phantom study T2 - 2009 Conference on Computer-Aided Diagnosis (MI103) AN - 41738874; 5010918 JF - 2009 Conference on Computer-Aided Diagnosis (MI103) AU - Gavrielides, Marios AU - Zeng, Rongping AU - Kinnard, Lisa AU - Myers, Kyle AU - Petrick, Nicholas Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Lung nodules KW - Nodules KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41738874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Computer-Aided+Diagnosis+%28MI103%29&rft.atitle=A+matched+fi+lter+approach+for+the+analysis+of+lung+nodules+in+a+volumetric+CT+phantom+study&rft.au=Gavrielides%2C+Marios%3BZeng%2C+Rongping%3BKinnard%2C+Lisa%3BMyers%2C+Kyle%3BPetrick%2C+Nicholas&rft.aulast=Gavrielides&rft.aufirst=Marios&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Computer-Aided+Diagnosis+%28MI103%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x12534&ID=x12171&redir=x12171.xml&conference_id=863802&event_ id=861972&jsenabled=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Noise and signal detection in digital x-ray detectors using the spatial definition of SNR T2 - 2009 Conference on Physics of Medical Imaging (MI101) AN - 41738541; 5010377 JF - 2009 Conference on Physics of Medical Imaging (MI101) AU - Kyprianou, Iacovos AU - Gallas, Brandon AU - Badano, Aldo AU - Park, Subok AU - Liu, Haimo AU - Myers, Kyle Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Noise levels KW - Ionizing radiation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41738541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Physics+of+Medical+Imaging+%28MI101%29&rft.atitle=Noise+and+signal+detection+in+digital+x-ray+detectors+using+the+spatial+definition+of+SNR&rft.au=Kyprianou%2C+Iacovos%3BGallas%2C+Brandon%3BBadano%2C+Aldo%3BPark%2C+Subok%3BLiu%2C+Haimo%3BMyers%2C+Kyle&rft.aulast=Kyprianou&rft.aufirst=Iacovos&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Physics+of+Medical+Imaging+%28MI101%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/Medical-Imaging2009-F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using partial least squares to compute effi cient channels for the Bayesian ideal observer T2 - 2009 Conference on Image Perception, Observer Performance, and Technology Assessment (MI106) AN - 41732726; 5011634 JF - 2009 Conference on Image Perception, Observer Performance, and Technology Assessment (MI106) AU - Witten, Joel AU - Park, Subok AU - Thompson, Laura AU - Myers, Kyle Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Bayesian analysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41732726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI106%29&rft.atitle=Using+partial+least+squares+to+compute+effi+cient+channels+for+the+Bayesian+ideal+observer&rft.au=Witten%2C+Joel%3BPark%2C+Subok%3BThompson%2C+Laura%3BMyers%2C+Kyle&rft.aulast=Witten&rft.aufirst=Joel&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI106%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/Medical-Imaging2009-F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Task based SNR methodology for mammography: comparison with CDMAM readings T2 - 2009 Conference on Physics of Medical Imaging (MI101) AN - 41729898; 5010381 JF - 2009 Conference on Physics of Medical Imaging (MI101) AU - Liu, Haimo AU - Kyprianou, Iacovos AU - Badano, Aldo AU - Park, Subok AU - Jennings, Robert AU - Myers, Kyle AU - Kaczmarek, Richard AU - Chakrabarti, Kish Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Language KW - Mammography KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41729898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Physics+of+Medical+Imaging+%28MI101%29&rft.atitle=Task+based+SNR+methodology+for+mammography%3A+comparison+with+CDMAM+readings&rft.au=Liu%2C+Haimo%3BKyprianou%2C+Iacovos%3BBadano%2C+Aldo%3BPark%2C+Subok%3BJennings%2C+Robert%3BMyers%2C+Kyle%3BKaczmarek%2C+Richard%3BChakrabarti%2C+Kish&rft.aulast=Liu&rft.aufirst=Haimo&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Physics+of+Medical+Imaging+%28MI101%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/Medical-Imaging2009-F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of ROC methods for partially paired data T2 - 2009 Conference on Image Perception, Observer Performance, and Technology Assessment (MI106) AN - 41727913; 5011639 JF - 2009 Conference on Image Perception, Observer Performance, and Technology Assessment (MI106) AU - Gallas, Brandon AU - Pesce, Lorenzo Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Data processing KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41727913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI106%29&rft.atitle=Comparison+of+ROC+methods+for+partially+paired+data&rft.au=Gallas%2C+Brandon%3BPesce%2C+Lorenzo&rft.aulast=Gallas&rft.aufirst=Brandon&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI106%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/Medical-Imaging2009-F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Non-localization and localization ROC analyses using clinically-based scoring T2 - 2009 Conference on Image Perception, Observer Performance, and Technology Assessment (MI106) AN - 41696211; 5011638 JF - 2009 Conference on Image Perception, Observer Performance, and Technology Assessment (MI106) AU - Paquerault, Sophie AU - Samuelson, Frank AU - Myers, Kyle AU - Smith, Robert Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41696211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI106%29&rft.atitle=Non-localization+and+localization+ROC+analyses+using+clinically-based+scoring&rft.au=Paquerault%2C+Sophie%3BSamuelson%2C+Frank%3BMyers%2C+Kyle%3BSmith%2C+Robert&rft.aulast=Paquerault&rft.aufirst=Sophie&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI106%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/Medical-Imaging2009-F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Finding order in complexity T2 - 2009 Conference on Image Perception, Observer Performance, and Technology Assessment (MI106) AN - 41693695; 5011625 JF - 2009 Conference on Image Perception, Observer Performance, and Technology Assessment (MI106) AU - Myers, Kyle Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41693695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI106%29&rft.atitle=Finding+order+in+complexity&rft.au=Myers%2C+Kyle&rft.aulast=Myers&rft.aufirst=Kyle&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Image+Perception%2C+Observer+Performance%2C+and+Technology+Assessment+%28MI106%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/Medical-Imaging2009-F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - State-of-the-Science Workshop Report: Issues and Approaches in Low-Dose-Response Extrapolation for Environmental Health Risk Assessment AN - 743485394; 201004-31-0315055 (CE); 12126222 (EN) AB - Low-dose extrapolation model selection for evaluating the health effects of environmental pollutants is a key component of the risk assessment process. At a workshop held in Baltimore, Maryland, on 23-24 April 2007, sponsored by U.S. Environmental Protection Agency and Johns Hopkins Risk Sciences and Public Policy Institute, a multidisciplinary group of experts reviewed the state of the science regarding low-dose extrapolation modeling and its application in environmental health risk assessments. Participants identified discussion topics based on a literature review, which included examples for which human responses to ambient exposures have been extensively characterized for cancer and/or noncancer outcomes. Topics included the need for formalized approaches and criteria to assess the evidence for mode of action (MOA), the use of human versus animal data, the use of MOA information in biologically based models, and the implications of interindividual variability, background disease processes, and background exposures in threshold versus nonthreshold model choice. Participants recommended approaches that differ from current practice for extrapolating high-dose animal data to low-dose human exposures, including categorical approaches for integrating information on MOA, statistical approaches such as model averaging, and inference-based models that explicitly consider uncertainty and interindividual variability. JF - Environmental Health Perspectives AU - White, Ronald H AU - Cote, Ila AU - Zeise, Lauren AU - Fox, Mary AU - Dominici, Francesca AU - Burke, Thomas A AU - White, Paul D AU - Hattis, Dale B AU - Samet, Jonathan M PY - 2009 SP - 283 EP - 287 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Extrapolation KW - Ecological risk assessment KW - Human KW - Risk assessment KW - Exposure KW - Workshops KW - Animals KW - Copyrights KW - Public policy KW - Pollutants KW - Criteria KW - Multidisciplinary KW - Uncertainty KW - Cancer KW - Thresholds KW - Risk KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743485394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=State-of-the-Science+Workshop+Report%3A+Issues+and+Approaches+in+Low-Dose-Response+Extrapolation+for+Environmental+Health+Risk+Assessment&rft.au=White%2C+Ronald+H%3BCote%2C+Ila%3BZeise%2C+Lauren%3BFox%2C+Mary%3BDominici%2C+Francesca%3BBurke%2C+Thomas+A%3BWhite%2C+Paul+D%3BHattis%2C+Dale+B%3BSamet%2C+Jonathan+M&rft.aulast=White&rft.aufirst=Ronald&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Association between Frequency of Chromosomal Aberrations and Cancer Risk Is Not Influenced by Genetic Polymorphisms in GSTM1 and GSTT1 AN - 743473842; 201004-31-0315065 (CE); 12126232 (EN) AB - BACKGROUND: The frequency of chromosomal aberrations (CA) in peripheral blood lymphocytes of healthy individuals has been associated with cancer risk. It is presently unclear whether this association is influenced by individual susceptibility factors such as genetic polymorphisms of xenobiotic-metabolizing enzymes. OBJECTIVES: To evaluate the role of polymorphisms in glutathione S-transferase (GST) M1 (GSTM1) and theta 1 (GSTT1) as effect modifiers of the association between CA and cancer risk. METHODS: A case-control study was performed pooling data from cytogenetic studies carried out in 1974-1995 in three laboratories in Italy, Norway, and Denmark. A total of 107 cancer cases were retrieved from national registries and matched to 291 controls. The subjects were classified as low, medium, and high by tertile of CA frequency. The data were analyzed by setting up a Bayesian model that included prior information about cancer risk by CA frequency. RESULTS: The association between CA frequency and cancer risk was confirmed [OR(medium) (odds ratio)(medium) = 1.5, 95% credibility interval (CrI), 0.9-2.5; OR(high) = 2.8, 95% CrI, 1.6-4.6], whereas no effect of the genetic polymorphism was observed. A much stronger association was seen in the Italian subset (OR(high)= 9.4, 95% CrI, 2.6-28.0), which was characterized by a lower technical variability of the cytogenetic analysis. CA level was particularly associated with cancer of the respiratory tract (OR(high)= 6.2, 95% CrI, 1.5-20.0), the genitourinary tract (OR(high) = 4.0, 95% CrI, 1.4-10.0), and the digestive tract (OR(high) = 2.8, 95% CrI, 1.2-5.8). CONCLUSIONS: Despite the small size of the study groups, our results substantiate the cancer risk predictivity of CA frequency, ruling against a strong modifying effect of GSTM1 and GSTT1 polymorphisms. JF - Environmental Health Perspectives AU - Rossi, Anna Maria AU - Hansteen, Inger-Lise AU - Skjelbred, Camilla Furu AU - Ballardin, Michela AU - Maggini, Valentina AU - Murgia, Elena AU - Tomei, Antonio AU - Viarengo, Paolo AU - Knudsen, Lisbeth E AU - Barale, Roberto AU - Norppa, Hannu AU - Bonassi, Stefano PY - 2009 SP - 203 EP - 208 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Cancer KW - Risk KW - Polymorphism KW - Genetics KW - Mathematical models KW - Aberration KW - Health KW - Maria KW - Lymphocytes KW - Copyrights KW - Blood KW - Intervals KW - Bayesian analysis KW - Enzymes KW - Control equipment KW - Glutathione KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743473842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Association+between+Frequency+of+Chromosomal+Aberrations+and+Cancer+Risk+Is+Not+Influenced+by+Genetic+Polymorphisms+in+GSTM1+and+GSTT1&rft.au=Rossi%2C+Anna+Maria%3BHansteen%2C+Inger-Lise%3BSkjelbred%2C+Camilla+Furu%3BBallardin%2C+Michela%3BMaggini%2C+Valentina%3BMurgia%2C+Elena%3BTomei%2C+Antonio%3BViarengo%2C+Paolo%3BKnudsen%2C+Lisbeth+E%3BBarale%2C+Roberto%3BNorppa%2C+Hannu%3BBonassi%2C+Stefano&rft.aulast=Rossi&rft.aufirst=Anna&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Rising CO2, Climate Change, and Public Health: Exploring the Links to Plant Biology AN - 743427624; 201004-31-0315071 (CE); 12126238 (EN) AB - BACKGROUND: Although the issue of anthropogenic climate forcing and public health is widely recognized, one fundamental aspect has remained underappreciated: the impact of climatic change on plant biology and the well-being of human systems. OBJECTIVES: We aimed to critically evaluate the extant and probable links between plant function and human health, drawing on the pertinent literature. DISCUSSION: Here we provide a number of critical examples that range over various health concerns related to plant biology and climate change, including aerobiology, contact dermatitis, pharmacology, toxicology, and pesticide use. CONCLUSIONS: There are a number of clear links among climate change, plant biology, and public health that remain underappreciated by both plant scientists and health care providers. We demonstrate the importance of such links in our understanding of climate change impacts and provide a list of key questions that will help to integrate plant biology into the current paradigm regarding climate change and human health. JF - Environmental Health Perspectives AU - Ziska, Lewis H AU - Epstein, Paul R AU - Schlesinger, William H PY - 2009 SP - 155 EP - 158 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Plants (organisms) KW - Climate change KW - Health KW - Biology KW - Links KW - Public health KW - Human KW - Contact dermatitis KW - Lists KW - Drawing KW - Pesticides KW - Health care KW - Pharmacology KW - Copyrights KW - Scientists KW - Carbon dioxide KW - Climate KW - Toxicology KW - Aerobiology KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743427624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Rising+CO2%2C+Climate+Change%2C+and+Public+Health%3A+Exploring+the+Links+to+Plant+Biology&rft.au=Ziska%2C+Lewis+H%3BEpstein%2C+Paul+R%3BSchlesinger%2C+William+H&rft.aulast=Ziska&rft.aufirst=Lewis&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Early Kidney Damage in a Population Exposed to Cadmium and Other Heavy Metals AN - 743417811; 201004-31-0315069 (CE); 12126236 (EN) AB - BACKGROUND: Exposure to heavy metals may cause kidney damage. The population living near the Avonmouth zinc smelter has been exposed to cadmium and other heavy metals for many decades. OBJECTIVES: We aimed to assess Cd body burden and early signs of kidney damage in the Avonmouth population. METHODS: We used dispersion modeling to assess exposure to Cd. We analyzed urine samples from the local population (n = 180) for Cd (U-Cd) to assess dose (body burden) and for three biomarkers of early kidney damage [N-acetyl-beta-d-glucosaminidase (U-NAG), retinol-binding protein, and alpha-1-microglobulin]. We collected information on occupation, intake of homegrown vegetables, smoking, and medical history by questionnaire. RESULTS: Median U-Cd concentrations were 0.22 nmol/mmol creatinine (nonsmoking 0.18/smoking 0.40) and 0.34 nmol/mmol creatinine (nonsmoking 0.31/smoking 0.46) in non-occupationally exposed men and women, respectively. There was a significant dose-response relationship between U-Cd and the prevalence of early renal damage-defined as U-NAG 0.22 IU/mmol-with odds ratios of 2.64 [95% confidence interval (95% CI), 0.70-9.97] and 3.64 (95% CI, 0.98-13.5) for U-Cd levels of 0.3 to 0.5 and levels or= 0.5 nmol/mmol creatinine, respectively (p for trend = 0.045). CONCLUSION: U-Cd concentrations were close to levels where kidney and bone effects have been found in other populations. The dose-response relationship between U-Cd levels and prevalence of U-NAG above the reference value support the need for measures to reduce environmental Cd exposure. JF - Environmental Health Perspectives AU - Thomas, Laura D K AU - Hodgson, Susan AU - Nieuwenhuijsen, Mark AU - Jarup, Lars PY - 2009 SP - 181 EP - 184 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Cadmium KW - Kidneys KW - Damage KW - Creatinine KW - Heavy metals KW - Smoking KW - Exposure KW - Health KW - Zinc KW - Bones KW - Dispersions KW - Medical KW - Occupation KW - Smelters KW - Mathematical models KW - Confidence intervals KW - Vegetables KW - Men KW - Copyrights KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743417811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Early+Kidney+Damage+in+a+Population+Exposed+to+Cadmium+and+Other+Heavy+Metals&rft.au=Thomas%2C+Laura+D+K%3BHodgson%2C+Susan%3BNieuwenhuijsen%2C+Mark%3BJarup%2C+Lars&rft.aulast=Thomas&rft.aufirst=Laura+D&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - RDX Induces Aberrant Expression of MicroRNAs in Mouse Brain and Liver AN - 743413548; 201004-31-0315061 (CE); 12126228 (EN) AB - BACKGROUND: Although microRNAs (miRNAs) have been found to play an important role in many biological and metabolic processes, their functions in animal response to environmental toxicant exposure are largely unknown. OBJECTIVES: We used hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a common environmental contaminant, as a toxicant stressor to investigate toxicant-induced changes in miRNA expression in B6C3F1 mice and the potential mechanism of RDX-induced toxic action. METHODS: B6C3F1 mice were fed diets with or without 5 mg/kg RDX for 28 days. After the feeding trials, we isolated RNAs from both brain and liver tissues and analyzed the expression profiles of 567 known mouse miRNAs using microarray and quantitative real-time polymerase chain reaction technologies. RESULTS: RDX exposure induced significant changes in miRNA expression profiles. A total of 113 miRNAs, belonging to 75 families, showed significantly altered expression patterns after RDX exposure. Of the 113 miRNAs, 10 were significantly up-regulated and 3 were significantly down-regulated (p 0.01) in both mouse brain and liver. Many miRNAs had tissue-specific responses to RDX exposure. Specifically, expression of seven miRNAs was up-regulated in the brain but down-regulated in the liver or up-regulated in the liver but down-regulated in the brain (p 0.01). Many aberrantly expressed miRNAs were related to various cancers, toxicant-metabolizing enzymes, and neurotoxicity. We found a significant up-regulation of oncogenic miRNAs and a significant down-regulation of tumor-suppressing miRNAs, which included let-7, miR-17-92, miR-10b, miR-15, miR-16, miR-26, and miR-181. CONCLUSIONS: Environmental toxicant exposure alters the expression of a suite of miRNAs. JF - Environmental Health Perspectives AU - Zhang, Baohong AU - Pan, Xiaoping PY - 2009 SP - 231 EP - 240 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - RDX KW - Liver KW - Brain KW - Mice KW - Health KW - Aberration KW - Enzymes KW - Ribonucleic acids KW - Contaminants KW - Biological KW - Toxic KW - Polymerase chain reaction KW - Cancer KW - Diets KW - Copyrights KW - Animals KW - Feeding KW - Real time KW - Toxicology KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743413548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=RDX+Induces+Aberrant+Expression+of+MicroRNAs+in+Mouse+Brain+and+Liver&rft.au=Zhang%2C+Baohong%3BPan%2C+Xiaoping&rft.aulast=Zhang&rft.aufirst=Baohong&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Quantitative Approach for Incorporating Methylmercury Risks and Omega-3 Fatty Acid Benefits in Developing Species-Specific Fish Consumption Advice AN - 743402944; 201004-31-0315056 (CE); 12126223 (EN) AB - BACKGROUND: Despite general agreement about the toxicity of methylmercury (MeHg), fish consumption advice remains controversial. Concerns have been raised that negative messages will steer people away from fish and omega-3 fatty acid (FA) benefits. One approach is to provide advice for individual species that highlights beneficial fish while cautioning against riskier fish. OBJECTIVES: Our goal in this study was to develop a method to quantitatively analyze the net risk/benefit of individual fish species based on their MeHg and omega-3 FA content. METHODS: We identified dose-response relationships for MeHg and omega-3 FA effects on coronary heart disease (CHD) and neurodevelopment. We used the MeHg and omega-3 FA content of 16 commonly consumed species to calculate the net risk/benefit for each species. RESULTS: Estimated omega-3 FA benefits outweigh MeHg risks for some species (e.g., farmed salmon, herring, trout); however, the opposite was true for others (swordfish, shark). Other species were associated with a small net benefit (e.g., flounder, canned light tuna) or a small net risk (e.g., canned white tuna, halibut). These results were used to place fish into one of four meal frequency categories, with the advice tentative because of limitations in the underlying dose-response information. Separate advice appears warranted for the neurodevelopmental risk group versus the cardiovascular risk group because we found a greater net benefit from fish consumption for the cardiovascular risk group. CONCLUSIONS: This research illustrates a framework for risk/benefit analysis that can be used to develop categories of consumption advice ranging from "do not eat" to "unlimited," with the caveat that unlimited may need to be tempered for certain fish (e.g., farm-raised salmon) because of other contaminants and end points (e.g., cancer risk). Uncertainties exist in the underlying dose-response relationships, pointing in particular to the need for more research on the adverse effects of MeHg on cardiovascular end points. JF - Environmental Health Perspectives AU - Ginsberg, Gary L AU - Toal, Brian F PY - 2009 SP - 267 EP - 275 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Fish KW - Categories KW - Fatty acids KW - Health KW - Tunas KW - Salmon KW - Halibut KW - Heart diseases KW - Toxicity KW - Consumption KW - Contaminants KW - Mathematical analysis KW - Cancer KW - Meals KW - Swordfish KW - Trout KW - Copyrights KW - Sharks KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743402944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Quantitative+Approach+for+Incorporating+Methylmercury+Risks+and+Omega-3+Fatty+Acid+Benefits+in+Developing+Species-Specific+Fish+Consumption+Advice&rft.au=Ginsberg%2C+Gary+L%3BToal%2C+Brian+F&rft.aulast=Ginsberg&rft.aufirst=Gary&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Particulate Matter (PM) Research Centers (1999-2005) and the Role of Interdisciplinary Center-Based Research AN - 743396152; 201004-31-0315070 (CE); 12126237 (EN) AB - OBJECTIVE: The U.S. Environmental Protection Agency funded five academic centers in 1999 to address the uncertainties in exposure, toxicity, and health effects of airborne particulate matter (PM) identified in the "Research Priorities for Airborne Particulate Matter" of the National Research Council (NRC). The centers were structured to promote interdisciplinary approaches to address research priorities of the NRC. In this report, we present selected accomplishments from the first 6 years of the PM Centers, with a focus on the advantages afforded by the interdisciplinary, center-based research approach. The review highlights advances in the area of ultrafine particles and traffic-related health effects as well as cardiovascular and respiratory effects, mechanisms, susceptibility, and PM exposure and characterization issues. DATA SOURCES AND SYNTHESIS: The collective publications of the centers served as the data source. To provide a concise synthesis of overall findings, authors representing each of the five centers identified a limited number of topic areas that serve to illustrate the key accomplishments of the PM Centers program, and a consensus statement was developed. CONCLUSIONS: The PM Centers program has effectively applied interdisciplinary research approaches to advance PM science. JF - Environmental Health Perspectives AU - Fanning, Elinor W AU - Froines, John R AU - Utell, Mark J AU - Lippmann, Morton AU - Oberdoerster, Gunter AU - Frampton, Mark AU - Godleski, John AU - Larson, Tim V PY - 2009 SP - 167 EP - 174 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Synthesis KW - Data sources KW - Priorities KW - Toxicity KW - Copyrights KW - Uncertainty KW - Ultrafines KW - Documents KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743396152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Particulate+Matter+%28PM%29+Research+Centers+%281999-2005%29+and+the+Role+of+Interdisciplinary+Center-Based+Research&rft.au=Fanning%2C+Elinor+W%3BFroines%2C+John+R%3BUtell%2C+Mark+J%3BLippmann%2C+Morton%3BOberdoerster%2C+Gunter%3BFrampton%2C+Mark%3BGodleski%2C+John%3BLarson%2C+Tim+V&rft.aulast=Fanning&rft.aufirst=Elinor&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Environment and Obesity in the National Children's Study AN - 743355786; 201004-31-0315072 (CE); 12126239 (EN) AB - OBJECTIVE: In this review we describe the approach taken by the National Children's Study (NCS), a 21-year prospective study of 100,000 American children, to understanding the role of environmental factors in the development of obesity. DATA SOURCES AND EXTRACTION: We review the literature with regard to the two core hypotheses in the NCS that relate to environmental origins of obesity and describe strategies that will be used to test each hypothesis. DATA SYNTHESIS: Although it is clear that obesity in an individual results from an imbalance between energy intake and expenditure, control of the obesity epidemic will require understanding of factors in the modern built environment and chemical exposures that may have the capacity to disrupt the link between energy intake and expenditure. The NCS is the largest prospective birth cohort study ever undertaken in the United States that is explicitly designed to seek information on the environmental causes of pediatric disease. CONCLUSIONS: Through its embrace of the life-course approach to epidemiology, the NCS will be able to study the origins of obesity from preconception through late adolescence, including factors ranging from genetic inheritance to individual behaviors to the social, built, and natural environment and chemical exposures. It will have sufficient statistical power to examine interactions among these multiple influences, including gene-environment and gene-obesity interactions. A major secondary benefit will derive from the banking of specimens for future analysis. JF - Environmental Health Perspectives AU - Trasande, Leonardo AU - Cronk, Chris AU - Durkin, Maureen AU - Weiss, Marianne AU - Schoeller, Dale A AU - Gall, Elizabeth A AU - Hewitt, Jeanne B AU - Carrel, Aaron L AU - Landrigan, Philip J AU - Gillman, Matthew W PY - 2009 SP - 159 EP - 166 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Obesity KW - Children KW - Expenditures KW - Health KW - Origins KW - Exposure KW - Intakes KW - Banking KW - Extraction KW - Epidemiology KW - Data sources KW - Links KW - Genetics KW - Strategy KW - Synthesis KW - Copyrights KW - Birth KW - Gall KW - Hypotheses KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743355786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Environment+and+Obesity+in+the+National+Children%27s+Study&rft.au=Trasande%2C+Leonardo%3BCronk%2C+Chris%3BDurkin%2C+Maureen%3BWeiss%2C+Marianne%3BSchoeller%2C+Dale+A%3BGall%2C+Elizabeth+A%3BHewitt%2C+Jeanne+B%3BCarrel%2C+Aaron+L%3BLandrigan%2C+Philip+J%3BGillman%2C+Matthew+W&rft.aulast=Trasande&rft.aufirst=Leonardo&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Analysis of Endocrine Disruption in Southern California Coastal Fish Using an Aquatic Multispecies Microarray AN - 743332612; 201004-31-0315062 (CE); 12126229 (EN) AB - BACKGROUND: Endocrine disruptors include plasticizers, pesticides, detergents, and pharmaceuticals. Turbot and other flatfish are used to characterize the presence of chemicals in the marine environment. Unfortunately, there are relatively few genes of turbot and other flatfish in GenBank, which limits the use of molecular tools such as microarrays and quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) to study disruption of endocrine responses in sentinel fish captured by regulatory agencies. OBJECTIVES: We fabricated a multigene cross-species microarray as a diagnostic tool to screen the effects of environmental chemicals in fish, for which there is minimal genomic information. The array included genes that are involved in the actions of adrenal and sex steroids, thyroid hormone, and xenobiotic responses. This microarray will provide a sensitive tool for screening for the presence of chemicals with adverse effects on endocrine responses in coastal fish species. METHODS: We used a custom multispecies microarray to study gene expression in wild hornyhead turbot (Pleuronichthys verticalis) collected from polluted and clean coastal waters and in laboratory male zebrafish (Danio rerio) after exposure to estradiol and 4-nonylphenol. We measured gene-specific expression in turbot liver by qRT-PCR and correlated it to microarray data. RESULTS: Microarray and qRT-PCR analyses of livers from turbot collected from polluted areas revealed altered gene expression profiles compared with those from nonaffected areas. CONCLUSIONS: The agreement between the array data and qRT-PCR analyses validates this multispecies microarray. The microarray measurement of gene expression in zebrafish, which are phylogenetically distant from turbot, indicates that this multispecies microarray will be useful for measuring endocrine responses in other fish. JF - Environmental Health Perspectives AU - Baker, Michael E AU - Ruggeri, Barbara AU - Sprague, L James AU - Eckhardt-Ludka, Colleen AU - Lapira, Jennifer AU - Wick, Ivan AU - Soverchia, Laura AU - Ubaldi, Massimo AU - Polzonetti-Magni, Alberta Maria AU - Vidal-Dorsch, Doris AU - Bay, Steven AU - Gully, Joseph R AU - Reyes, Jesus A AU - Kelley, Kevin M AU - Schlenk, Daniel AU - Breen, Ellen C AU - Sasik, Roman AU - Hardiman, Gary PY - 2009 SP - 223 EP - 230 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Fish KW - Genes KW - Arrays KW - Coastal KW - Health KW - Zebrafish KW - Disruption KW - Liver KW - Plasticizers KW - Gullies KW - Wicks KW - Roman KW - Marine environments KW - Detergents KW - Endocrine disruptors KW - Southern California KW - Hormones KW - Cleaning KW - Regulatory agencies KW - Article KW - EE 40:Water Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743332612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Analysis+of+Endocrine+Disruption+in+Southern+California+Coastal+Fish+Using+an+Aquatic+Multispecies+Microarray&rft.au=Baker%2C+Michael+E%3BRuggeri%2C+Barbara%3BSprague%2C+L+James%3BEckhardt-Ludka%2C+Colleen%3BLapira%2C+Jennifer%3BWick%2C+Ivan%3BSoverchia%2C+Laura%3BUbaldi%2C+Massimo%3BPolzonetti-Magni%2C+Alberta+Maria%3BVidal-Dorsch%2C+Doris%3BBay%2C+Steven%3BGully%2C+Joseph+R%3BReyes%2C+Jesus+A%3BKelley%2C+Kevin+M%3BSchlenk%2C+Daniel%3BBreen%2C+Ellen+C%3BSasik%2C+Roman%3BHardiman%2C+Gary&rft.aulast=Baker&rft.aufirst=Michael&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - In-Home Particle Concentrations and Childhood Asthma Morbidity AN - 743327124; 201004-31-0315050 (CE); 12126216 (EN) AB - BACKGROUND: Although outdoor particulate matter (PM) has been linked to mortality and asthma morbidity, the impact of indoor PM on asthma has not been well established. OBJECTIVE: This study was designed to investigate the effect of in-home PM on asthma morbidity. METHODS: For a cohort of 150 asthmatic children (2-6 years of age) from Baltimore, Maryland, a technician deployed environmental monitoring equipment in the children's bedrooms for 3-day intervals at baseline and at 3 and 6 months. Caregivers completed questionnaires and daily diaries during air sampling. Longitudinal data analyses included regression models with generalized estimating equations. RESULTS: Children were primarily African Americans (91%) from lower socioeconomic backgrounds and spent most of their time in the home. Mean (+/- SD) indoor PM(2.5-10) (PM with aerodynamic diameter 2.5-10 microm) and PM(2.5) (aerodynamic diameter 2.5 microm) concentrations were 17.4 +/- 21.0 and 40.3 +/- 35.4 microg/m(3). In adjusted models, 10-microg/m(3) increases in indoor PM(2.5-10) and PM(2.5) were associated with increased incidences of asthma symptoms: 6% [95% confidence interval (CI), 1 to 12%] and 3% (95% CI, -1 to 7%), respectively; symptoms causing children to slow down: 8% (95% CI, 2 to 14%) and 4% (95% CI, 0 to 9%), respectively; nocturnal symptoms: 8% (95% CI, 1 to 14%) and 6% (95% CI, 1 to 10%), respectively; wheezing that limited speech: 11% (95% CI, 3 to 19%) and 7% (95% CI, 0 to 14%), respectively; and use of rescue medication: 6% (95% CI, 1 to 10%) and 4% (95% CI, 1 to 8%), respectively. Increases of 10 microg/m(3) in indoor and ambient PM(2.5) were associated with 7% (95% CI, 2 to 11%) and 26% (95% CI, 1 to 52%) increases in exercise-related symptoms, respectively. CONCLUSIONS: Among preschool asthmatic children in Baltimore, increases in in-home PM(2.5-10) and PM(2.5) were associated with respiratory symptoms and rescue medication use. Increases in in-home and ambient PM(2.5) were associated with exercise-related symptoms. Although reducing PM outdoors may decrease asthma morbidity, reducing PM indoors, especially in homes of inner-city children, may lead to improved asthma health. JF - Environmental Health Perspectives AU - McCormack, Meredith C AU - Breysse, Patrick N AU - Matsui, Elizabeth C AU - Hansel, Nadia N AU - Williams, D'Ann AU - Curtin-Brosnan, Jean AU - Eggleston, Peyton AU - Diette, Gregory B PY - 2009 SP - 294 EP - 298 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Asthma KW - Children KW - Indoor KW - Health KW - Mathematical models KW - Aerodynamics KW - Outdoor KW - Estimating KW - Bedrooms KW - Air sampling KW - Regression KW - Intervals KW - Diaries KW - Mortality KW - Mathematical analysis KW - Confidence intervals KW - Speech KW - Copyrights KW - Data processing KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743327124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=In-Home+Particle+Concentrations+and+Childhood+Asthma+Morbidity&rft.au=McCormack%2C+Meredith+C%3BBreysse%2C+Patrick+N%3BMatsui%2C+Elizabeth+C%3BHansel%2C+Nadia+N%3BWilliams%2C+D%27Ann%3BCurtin-Brosnan%2C+Jean%3BEggleston%2C+Peyton%3BDiette%2C+Gregory+B&rft.aulast=McCormack&rft.aufirst=Meredith&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Endocrine Disruptors in the Workplace, Hair Spray, Folate Supplementation, and Risk of Hypospadias: Case-Control Study AN - 743316559; 201004-31-0315052 (CE); 12126218 (EN) AB - BACKGROUND: Hypospadias is one of the most common urogenital congenital anomalies affecting baby boys. Prevalence estimates in Europe range from 4 to 24 per 10,000 births, depending on definition, with higher rates reported from the United States. Relatively little is known about potential risk factors, but a role for endocrine-disrupting chemicals (EDCs) has been proposed. OBJECTIVE: Our goal was to elucidate the risk of hypospadias associated with occupational exposure of the mother to endocrine-disruptor chemicals, use of folate supplementation during pregnancy, and vegetarianism. DESIGN: We designed a case-control study of 471 hypospadias cases referred to surgeons and 490 randomly selected birth controls, born 1 January 1997-30 September 1998 in southeast England. Telephone interviews of mothers elicited information on folate supplementation during pregnancy and vegetarianism. We used a job exposure matrix to classify occupational exposure. RESULTS: In multiple logistic regression analysis, there were increased risks for self-reported occupational exposure to hair spray [exposed vs. nonexposed, odds ratio (OR) = 2.39; 95% confidence interval (CI), 1.40-4.17] and phthalate exposure obtained by a job exposure matrix (OR = 3.12; 95% CI, 1.04-11.46). There was a significantly reduced risk of hypospadias associated with of folate use during the first 3 months of pregnancy (OR = 0.64; 95% CI, 0.44-0.93). Vegetarianism was not associated with hypospadias risk. CONCLUSIONS: Excess risks of hypospadias associated with occupational exposures to phthalates and hair spray suggest that antiandrogenic EDCs may play a role in hypospadias. Folate supplementation in early pregnancy may be protective. JF - Environmental Health Perspectives AU - Ormond, Gillian AU - Nieuwenhuijsen, Mark J AU - Nelson, Paul AU - Toledano, Mireille B AU - Iszatt, Nina AU - Geneletti, Sara AU - Elliott, Paul PY - 2009 SP - 303 EP - 307 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Pregnancy KW - Occupational KW - Sprays KW - Hair KW - Sprayers KW - Health KW - Birth KW - Phthalates KW - Protective KW - Estimates KW - Endocrine disruptors KW - Regression analysis KW - Surgeons KW - Confidence intervals KW - Classification KW - Congenital anomalies KW - Workplaces KW - Telephones KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743316559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Endocrine+Disruptors+in+the+Workplace%2C+Hair+Spray%2C+Folate+Supplementation%2C+and+Risk+of+Hypospadias%3A+Case-Control+Study&rft.au=Ormond%2C+Gillian%3BNieuwenhuijsen%2C+Mark+J%3BNelson%2C+Paul%3BToledano%2C+Mireille+B%3BIszatt%2C+Nina%3BGeneletti%2C+Sara%3BElliott%2C+Paul&rft.aulast=Ormond&rft.aufirst=Gillian&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.08.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Metabolism of Polybrominated Diphenyl Ethers (PBDEs) by Human Hepatocytes in Vitro AN - 743304170; 201004-31-0315066 (CE); 12126233 (EN) AB - BACKGROUND: Polybrominated diphenyl ethers (PBDEs) are flame-retardant chemicals that accumulate in human tissues and are potential toxicants. Concentrations of PBDEs in human tissues have increased recently, and body burdens in the U.S. and Canadian populations are higher than in any other region. OBJECTIVES: Although metabolism in animal laboratory studies has been examined, no studies have explored the metabolism of these contaminants in human tissues. We undertook this study to determine whether PBDEs could be metabolized by human liver cells in vitro and to identify what types of metabolites are formed. METHODS: We exposed hepatocytes from three different donors (two cryopreserved batches and one fresh batch) to solutions containing 10 muM of either of two environmentally relevant and prominent PBDE congeners-BDE-99 or BDE-209-for periods of 24-72 hr. We also conducted gene expression analysis to provide information on potential induction of xenobiotic metabolizing enzymes. RESULTS: Exposing hepatocytes to BDE-99 resulted in the formation of 2,4,5-tribromo phenol, two monohydroxylated pentabrominated diphenyl ether metabolites, and a yet unidentified tetrabrominated metabolite. No hydroxylated or debrominated metabolites were observed in the cells exposed to BDE-209. This suggests that BDE-209 was not metabolized, that nonextractable, covalently protein-bound metabolites were formed, or that the exposure time was not long enough for BDE-209 to diffuse into the cell to be metabolized. However, we observed up-regulation of genes encoding for cytochrome P450 monooxygenase (CYP) 1A2, CYP3A4, deiodinase type 1, and glutathione S-transferase M1 in hepatocyes exposed to both BDE-99 and BDE-209. CONCLUSIONS: Our in vitro results suggest that the human liver will likely metabolize some BDE congeners (e.g., BDE-99) in vivo. These metabolites have been shown to elicit greater toxicity than the parent BDE congeners in laboratory bioassays; thus, more research on body burdens and human health effects from these metabolites are warranted. JF - Environmental Health Perspectives AU - Stapleton, Heather M AU - Kelly, Shannon M AU - Pei, Ruoting AU - Letcher, Robert J AU - Gunsch, Claudia PY - 2009 SP - 197 EP - 202 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Metabolites KW - Human KW - Exposure KW - Ethers KW - In vitro testing KW - Health KW - Human tissues KW - Metabolism KW - Congeners KW - Liver KW - Biocompatibility KW - Enzymes KW - Toxicity KW - Gene expression KW - Encoding KW - Phenol KW - Surgical implants KW - Contaminants KW - Polyetherimides KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743304170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Metabolism+of+Polybrominated+Diphenyl+Ethers+%28PBDEs%29+by+Human+Hepatocytes+in+Vitro&rft.au=Stapleton%2C+Heather+M%3BKelly%2C+Shannon+M%3BPei%2C+Ruoting%3BLetcher%2C+Robert+J%3BGunsch%2C+Claudia&rft.aulast=Stapleton&rft.aufirst=Heather&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Mortality among Former Love Canal Residents AN - 743303479; 201004-31-0315064 (CE); 12126231 (EN) AB - BACKGROUND: The Love Canal was a rectangular 16-acre, 10-ft-deep chemical waste landfill situated in a residential neighborhood in Niagara Falls, New York. This seriously contaminated site came to public attention in 1978. Only one prior study examined cancer incidence in former residents of the Love Canal neighborhood (LC). OBJECTIVE: In this study we aimed to describe cancer incidence in former LC residents from 1979 to 1996 and to investigate whether it differs from that of New York State (NYS) and Niagara County (NC). METHODS: From 1978 to 1982, we interviewed 6,181 former residents, and 5,052 were eligible to be included in this study. In 1996, we identified 304 cancer diagnoses in this cohort using the NYS Cancer Registry. We compared LC cancer incidence with that of NYS and NC using standardized incidence ratios (SIRs), and we compared risks within the LC group by potential exposure to the landfill using survival analysis. RESULTS: SIRs were elevated for cancers of the bladder [SIR(NYS) = 1.44; 95% confidence interval (CI), 0.91-2.16] and kidney (SIR(NYS) = 1.48; 95% CI, 0.76-2.58). Although CIs included 1.00, other studies have linked these cancers to chemicals similar to those found at Love Canal. We also found higher rates of bladder cancer among residents exposed as children, based on two cases. CONCLUSIONS: In explaining these excess risks, the role of exposure to the landfill is unclear given such limitations as a relatively small and incomplete study cohort, imprecise exposure measurements, and the exclusion of cancers diagnosed before 1979. Given the relatively young age of the cohort, further surveillance is warranted. JF - Environmental Health Perspectives AU - Gensburg, Lenore J AU - Pantea, Cristian AU - Fitzgerald, Edward AU - Stark, Alice AU - Hwang, Syni-An AU - Kim, Nancy PY - 2009 SP - 1265 EP - 1271 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Cancer KW - Incidence KW - Canals KW - Landfills KW - Numerical control KW - Risk KW - Health KW - Bladder KW - Austenitic stainless steels KW - Kidneys KW - Children KW - Mortality KW - Confidence intervals KW - Elevated KW - Surveillance KW - Wastes KW - Copyrights KW - Survival KW - Age KW - Article KW - EE 60:Waste Management (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743303479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Mortality+among+Former+Love+Canal+Residents&rft.au=Gensburg%2C+Lenore+J%3BPantea%2C+Cristian%3BFitzgerald%2C+Edward%3BStark%2C+Alice%3BHwang%2C+Syni-An%3BKim%2C+Nancy&rft.aulast=Gensburg&rft.aufirst=Lenore&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Modification by Influenza on Health Effects of Air Pollution in Hong Kong AN - 743284951; 201004-31-0315059 (CE); 12126226 (EN) AB - BACKGROUND: Both influenza viruses and air pollutants have been well documented as major hazards to human health, but few epidemiologic studies have assessed effect modification of influenza on health effects of ambient air pollutants. OBJECTIVES: We aimed to assess modifying effects of influenza on health effects of ambient air pollutants. METHODS: We applied Poisson regression to daily numbers of hospitalizations and mortality to develop core models after adjustment for potential time-varying confounding variables. We assessed modification of influenza by adding variables for concentrations of single ambient air pollutants and proportions of influenza-positive specimens (influenza intensity) and their cross-product terms. RESULTS: We found significant effect modification of influenza (p 0.05) for effects of ozone. When influenza intensity is assumed to increase from 0% to 10%, the excess risks per 10-microg/m(3) increase in concentration of O(3) increased 0.24% and 0.40% for hospitalization of respiratory disease in the all-ages group and or= 65 year age group, respectively; 0.46% for hospitalization of acute respiratory disease in the all-ages group; and 0.40% for hospitalization of chronic obstructive pulmonary disease in the or= 65 group. The estimated increases in the excess risks for mortality of respiratory disease and chronic obstructive pulmonary disease in the all-ages group were 0.59% and 1.05%, respectively. We found no significant modification of influenza on effects of other pollutants in most disease outcomes under study. CONCLUSIONS: Influenza activity could be an effect modifier for the health effects of air pollutants particularly for O(3) and should be considered in the studies for short-term effects of air pollutants on health. JF - Environmental Health Perspectives AU - Wong, Chit Ming AU - Yang, Lin AU - Thach, Thuan Quoc AU - Chau, Patsy Yuen Kwan AU - Chan, King Pan AU - Thomas, G Neil AU - Lam, Tai Hing AU - Wong, Tze Wai AU - Hedley, Anthony J AU - Peiris, J S Malik PY - 2009 SP - 248 EP - 253 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Influenza KW - Health KW - Pollutants KW - Mathematical models KW - Respiratory diseases KW - Mortality KW - Risk KW - Regression KW - Viruses KW - Copyrights KW - Air pollution KW - Human KW - Epidemiology KW - Ozone KW - Age KW - Hazards KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743284951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Modification+by+Influenza+on+Health+Effects+of+Air+Pollution+in+Hong+Kong&rft.au=Wong%2C+Chit+Ming%3BYang%2C+Lin%3BThach%2C+Thuan+Quoc%3BChau%2C+Patsy+Yuen+Kwan%3BChan%2C+King+Pan%3BThomas%2C+G+Neil%3BLam%2C+Tai+Hing%3BWong%2C+Tze+Wai%3BHedley%2C+Anthony+J%3BPeiris%2C+J+S+Malik&rft.aulast=Wong&rft.aufirst=Chit&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Medications as a Potential Source of Exposure to Phthalates in the U.S. Population AN - 743282185; 201004-31-0315068 (CE); 12126235 (EN) AB - BACKGROUND: Widespread human exposure to phthalates, some of which are developmental and reproductive toxicants in experimental animals, raises concerns about potential human health risks. Underappreciated sources of exposure include phthalates in the polymers coating some oral medications. OBJECTIVE: The objective of this study was to evaluate whether users of phthalate-containing medications have higher urinary concentrations of phthalate metabolites than do nonusers. METHODS: We used publically available files from the National Health and Nutrition Examination Survey for the years 1999-2004. For certain survey periods, participants were asked to recall use of prescription medication during the past 30 days, and for a subsample of individuals, the urinary concentrations of phthalate metabolites were measured. We a priori identified medications potentially containing phthalates as inactive ingredients and then compared the mean urinary concentration of phthalate metabolites between users and nonusers of those medications. RESULTS: Of the 7,999 persons with information on urinary phthalate concentrations, 6 reported using mesalamine formulations, some of which may include dibutyl phthalate (DBP); the mean urinary concentration of monobutyl phthalate, the main DBP metabolite, among these mesalamine users was 50 times higher than the mean for nonusers (2,257 microg/L vs. 46 microg/L; p 0.0001). Users of didanosine, omeprazole, and theophylline products, some of which may contain diethyl phthalate (DEP), had mean urinary concentrations of monoethyl phthalate, the main DEP metabolite, significantly higher than the mean for nonusers. CONCLUSION: Select medications might be a source of high exposure to some phthalates, one of which, DBP, shows adverse developmental and reproductive effects in laboratory animals. These results raise concern about potential human health risks, specifically among vulnerable segments of the general population and particularly pregnant women and children. JF - Environmental Health Perspectives AU - Hernandez-Diaz, Sonia AU - Mitchell, Allen A AU - Kelley, Katherine E AU - Calafat, Antonia M AU - Hauser, Russ PY - 2009 SP - 185 EP - 189 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Phthalates KW - Metabolites KW - Health KW - Human KW - Risk KW - Nutrition KW - Recall KW - Children KW - Ingredients KW - Laboratory animals KW - Polymers KW - Copyrights KW - Segments KW - Coating KW - Dibutyl phthalate KW - Animals KW - Formulations KW - Theophylline KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743282185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Medications+as+a+Potential+Source+of+Exposure+to+Phthalates+in+the+U.S.+Population&rft.au=Hernandez-Diaz%2C+Sonia%3BMitchell%2C+Allen+A%3BKelley%2C+Katherine+E%3BCalafat%2C+Antonia+M%3BHauser%2C+Russ&rft.aulast=Hernandez-Diaz&rft.aufirst=Sonia&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - How the Effect of Maternal Age on the Risk of Childhood Leukemia Changed over Time in Sweden, 1960-2004 AN - 743241722; 201004-31-0315051 (CE); 12126217 (EN) AB - BACKGROUND: Previous studies on the association between maternal age and risk of childhood leukemia found inconsistent results. OBJECTIVES: We aimed to assess whether there is an association between maternal age and risk of childhood leukemia and whether such an association is modified by maternal year of birth. METHODS: By linking nationwide Swedish registers, we analyzed leukemia incidence among all children between 1 and 5 years of age born between 1960 and 1999. We estimated incidence time trends by child year of birth (overall and stratified by maternal age) and incidence rate ratios (RRs) for maternal age groups stratified by maternal birth cohort. We tested the interaction between maternal age and child year of birth through the likelihood ratio test between nested Poisson regression models. RESULTS: We observed 1,562 leukemia cases. The overall annual percent change (APC) was 1.00 [95% confidence interval (CI), 0.51 to 1.49]. Stratifying by maternal age classes, APCs decreased from 1.66 (0.68 to 2.65) for mothers or= 24 years to 0.23 (-0.93 to 1.40) for mothers or= 35 years at delivery. RRs for children born to the oldest with respect to the youngest mothers were 2.42 (1.31 to 4.67), 1.68 (1.00 to 2.72), 1.34 (0.87 to 2.01), and 0.87 (0.46-1.54) for mothers born in 1930-1934, 1940-1944, 1950-1954, and 1960-1964, respectively. CONCLUSIONS: Childhood leukemia risk increased with maternal age for mothers born in the past, whereas maternal age had no effect on this risk for mothers born more recently. This finding may explain the inconsistency of previous studies and suggests that leukemia risk may be related to an environmental factor to which women's exposure has changed over time. JF - Environmental Health Perspectives AU - Maule, Milena Maria AU - Vizzini, Loredana AU - Czene, Kamila AU - Akre, Olof AU - Richiardi, Lorenzo PY - 2009 SP - 299 EP - 302 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Age KW - Leukemias KW - Risk KW - Birth KW - Incidence KW - Children KW - Health KW - Mathematical models KW - Regression KW - Ecological risk assessment KW - Confidence intervals KW - Registers KW - Linking KW - Copyrights KW - Maria KW - Joining KW - Likelihood ratio KW - Trends KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743241722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=How+the+Effect+of+Maternal+Age+on+the+Risk+of+Childhood+Leukemia+Changed+over+Time+in+Sweden%2C+1960-2004&rft.au=Maule%2C+Milena+Maria%3BVizzini%2C+Loredana%3BCzene%2C+Kamila%3BAkre%2C+Olof%3BRichiardi%2C+Lorenzo&rft.aulast=Maule&rft.aufirst=Milena&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Folate Deficiency, Hyperhomocysteinemia, Low Urinary Creatinine, and Hypomethylation of Leukocyte DNA Are Risk Factors for Arsenic-Induced Skin Lesions AN - 743195770; 201004-31-0315058 (CE); 12126225 (EN) AB - BACKGROUND: Arsenic methylation relies on folate-dependent one-carbon metabolism and facilitates urinary As elimination. Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility. OBJECTIVE: After determining that folate deficiency, hyperhomocysteinemia, and low urinary creatinine are associated with reduced As methylation, and that As exposure is associated with increased genomic methylation of leukocyte DNA, we asked whether these factors are associated with As-induced skin lesion risk among Bangladeshi adults. METHODS: We conducted a nested case-control study of 274 cases who developed lesions 2 years after recruitment, and 274 controls matched to cases for sex, age, and water As. RESULTS: The odds ratios and 95% confidence intervals (CIs) for development of skin lesions for participants who had low folate ( 9 nmol/L), hyperhomocysteinemia (men, 11.4 micromol/L; women, 10.4 micromol/L), or hypomethylated leukocyte DNA at recruitment ( median) were 1.8 (95% CI, 1.1-2.9), 1.7 (95% CI, 1.1-2.6), and 1.8 (95% CI, 1.2-2.8), respectively. Compared with the subjects in the first quartile, those in the third and fourth quartiles for urinary creatinine had a 0.4-fold decrease in the odds of skin lesions (p 0.01). CONCLUSIONS: These results suggest that folate deficiency, hyperhomocysteinemia, and low urinary creatinine, each associated with decreased As methylation, are risk factors for As-induced skin lesions. The increased DNA methylation associated with As exposure previously observed, and confirmed among controls in this study, may be an adaptive change because hypomethylation of leukocyte DNA is associated with increased risk for skin lesions. JF - Environmental Health Perspectives AU - Pilsner, J Richard AU - Liu, Xinhua AU - Ahsan, Habibul AU - Ilievski, Vesna AU - Slavkovich, Vesna AU - Levy, Diane AU - Factor-Litvak, Pam AU - Graziano, Joseph H AU - Gamble, Mary V PY - 2009 SP - 254 EP - 260 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Lesions KW - Methylation KW - Deoxyribonucleic acid KW - Risk KW - Leukocytes KW - Creatinine KW - Recruitment KW - Health KW - Quartiles KW - Control equipment KW - Arsenic KW - Toxicity KW - Adults KW - Populations KW - Confidence intervals KW - Adaptive control systems KW - Men KW - Copyrights KW - Metabolism KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743195770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Folate+Deficiency%2C+Hyperhomocysteinemia%2C+Low+Urinary+Creatinine%2C+and+Hypomethylation+of+Leukocyte+DNA+Are+Risk+Factors+for+Arsenic-Induced+Skin+Lesions&rft.au=Pilsner%2C+J+Richard%3BLiu%2C+Xinhua%3BAhsan%2C+Habibul%3BIlievski%2C+Vesna%3BSlavkovich%2C+Vesna%3BLevy%2C+Diane%3BFactor-Litvak%2C+Pam%3BGraziano%2C+Joseph+H%3BGamble%2C+Mary+V&rft.aulast=Pilsner&rft.aufirst=J&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Effect of Arsenic Exposure during Pregnancy on Infant Development at 7 Months in Rural Matlab, Bangladesh AN - 743195458; 201004-31-0315054 (CE); 12126221 (EN) AB - BACKGROUND: Exposure to arsenic-contaminated drinking water during pregnancy is associated with low birth weight and fetal loss, and there is concern that the infants' development may be affected. OBJECTIVE: We assessed the effects of in utero arsenic exposure during pregnancy on infants' problem-solving ability and motor development. METHODS: We conducted a large population-based study of nutritional supplementation with 4,436 pregnant women in Matlab, Bangladesh, an area of high-arsenic-contaminated tube wells. We measured arsenic concentration in spot urine specimens at 8 and 30 weeks of pregnancy. We assessed a subsample of 1,799 infants, born to these mothers, at 7 months of age on two problem-solving tests (PSTs), the motor scale of the Bayley Scales of Infant Development-II, and behavior ratings. RESULT: Arsenic concentrations in maternal urine were high, with a median (interquartile range) of 81 microg/L (37-207 microg/L) at 8 weeks of gestation and of 84 microg/L (42-230 microg/L) at 30 weeks. Arsenic exposure was related to many poor socioeconomic conditions that also correlated with child development measures. Multiple regressions of children's motor and PST scores and behavior ratings, controlling for socioeconomic background variables, age, and sex, showed no significant effect of urinary arsenic concentration on any developmental outcome. CONCLUSION: We detected no significant effect of arsenic exposure during pregnancy on infant development. However, it is possible that other effects are as yet unmeasured or that effects will become apparent at a later age. JF - Environmental Health Perspectives AU - Tofail, Fahmida AU - Vahter, Marie AU - Hamadani, Jena D AU - Nermell, Barbro AU - Huda, Syed N AU - Yunus, Mohammad AU - Rahman, Mahfuzar AU - Grantham-McGregor, Sally M PY - 2009 SP - 288 EP - 293 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Arsenic KW - Infants KW - Pregnancy KW - Matlab KW - Motors KW - Age KW - Gestation KW - Ratings KW - Health KW - Urine KW - Drinking water KW - Children KW - Tubes KW - Correlation analysis KW - Copyrights KW - Birth KW - Sex KW - Wells KW - Rural KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743195458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Effect+of+Arsenic+Exposure+during+Pregnancy+on+Infant+Development+at+7+Months+in+Rural+Matlab%2C+Bangladesh&rft.au=Tofail%2C+Fahmida%3BVahter%2C+Marie%3BHamadani%2C+Jena+D%3BNermell%2C+Barbro%3BHuda%2C+Syed+N%3BYunus%2C+Mohammad%3BRahman%2C+Mahfuzar%3BGrantham-McGregor%2C+Sally+M&rft.aulast=Tofail&rft.aufirst=Fahmida&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation AN - 743194632; 201004-31-0315063 (CE); 12126230 (EN) AB - BACKGROUND: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined. OBJECTIVES: We aimed at identifying short- and long-term effects of PM exposure on DNA methylation, a major genomic mechanism of gene expression control, in workers in an electric furnace steel plant with well-characterized exposure to PM with aerodynamic diameters 10 microm (PM(10)). METHODS: We measured global genomic DNA methylation content estimated in Alu and long interspersed nuclear element-1 (LINE-1) repeated elements, and promoter DNA methylation of iNOS (inducible nitric oxide synthase), a gene suppressed by DNA methylation and induced by PM exposure in blood leukocytes. Quantitative DNA methylation analysis was performed through bisulfite PCR pyrosequencing on blood DNA obtained from 63 workers on the first day of a work week (baseline, after 2 days off work) and after 3 days of work (postexposure). Individual PM(10) exposure was between 73.4 and 1,220 microg/m(3). RESULTS: Global methylation content estimated in Alu and LINE-1 repeated elements did not show changes in postexposure measures compared with baseline. PM(10) exposure levels were negatively associated with methylation in both Alu [beta = -0.19 %5-methylcytosine (%5mC); p = 0.04] and LINE-1 [beta = -0.34 %5mC; p = 0.04], likely reflecting long-term PM(10) effects. iNOS promoter DNA methylation was significantly lower in postexposure blood samples compared with baseline (difference = -0.61 %5mC; p = 0.02). CONCLUSIONS: We observed changes in global and gene specific methylation that should be further characterized in future investigations on the effects of PM. JF - Environmental Health Perspectives AU - Tarantini, Letizia AU - Bonzini, Matteo AU - Apostoli, Pietro AU - Pegoraro, Valeria AU - Bollati, Valentina AU - Marinelli, Barbara AU - Cantone, Laura AU - Rizzo, Giovanna AU - Hou, Lifang AU - Schwartz, Joel AU - Bertazzi, Pier Alberto AU - Baccarelli, Andrea PY - 2009 SP - 217 EP - 222 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Methylation KW - Deoxyribonucleic acid KW - Blood KW - Gene expression KW - Health KW - Beta KW - Genes KW - Iron and steel plants KW - Copyrights KW - Human KW - Power plants KW - Electric furnace steels KW - Nitric oxide KW - Leukocytes KW - Piers KW - Aerodynamics KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743194632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Effects+of+Particulate+Matter+on+Genomic+DNA+Methylation+Content+and+iNOS+Promoter+Methylation&rft.au=Tarantini%2C+Letizia%3BBonzini%2C+Matteo%3BApostoli%2C+Pietro%3BPegoraro%2C+Valeria%3BBollati%2C+Valentina%3BMarinelli%2C+Barbara%3BCantone%2C+Laura%3BRizzo%2C+Giovanna%3BHou%2C+Lifang%3BSchwartz%2C+Joel%3BBertazzi%2C+Pier+Alberto%3BBaccarelli%2C+Andrea&rft.aulast=Tarantini&rft.aufirst=Letizia&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Efficacy of Simple Short-Term in Vitro Assays for Predicting the Potential of Metal Oxide Nanoparticles to Cause Pulmonary Inflammation AN - 743190028; 201004-31-0315060 (CE); 12126227 (EN) AB - BACKGROUND: There has been concern regarding risks from inhalation exposure to nanoparticles (NPs). The large number of particles requiring testing means that alternative approaches to animal testing are needed. OBJECTIVES: We set out to determine whether short-term in vitro assays that assess intrinsic oxidative stress potential and membrane-damaging potency of a panel of metal oxide NPs can be used to predict their inflammogenic potency. METHODS: For a panel of metal oxide NPs, we investigated intrinsic free radical generation, oxidative activity in an extracellular environment, cytotoxicity to lung epithelial cells, hemolysis, and inflammation potency in rat lungs. All exposures were carried out at equal surface area doses. RESULTS: Only nickel oxide (NiO) and alumina 2 caused significant lung inflammation when instilled into rat lungs at equal surface area, suggesting that these two had extra surface reactivity. We observed significant free radical generation with 4 of 13 metal oxides, only one of which was inflammogenic. Only 3 of 13 were significantly hemolytic, two of which were inflammogenic. CONCLUSIONS: Potency in generating free radicals in vitro did not predict inflammation, whereas alumina 2 had no free radical activity but was inflammogenic. The hemolysis assay was correct in predicting the proinflammatory potential of 12 of 13 of the particles examined. Using a battery of simple in vitro tests, it is possible to predict the inflammogenicity of metal oxide NPs, although some false-positive results are likely. More research using a larger panel is needed to confirm the efficacy and generality of this approach for metal oxide NPs. JF - Environmental Health Perspectives AU - Lu, Senlin AU - Duffin, Rodger AU - Poland, Craig AU - Daly, Paul AU - Murphy, Fiona AU - Drost, Ellen AU - MacNee, William AU - Stone, Vicki AU - Donaldson, Ken PY - 2009 SP - 241 EP - 247 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Metal oxides KW - Free radicals KW - In vitro testing KW - Lungs KW - Panels KW - Assaying KW - Health KW - Hemolysis KW - Aluminum oxide KW - Surface area KW - Nanoparticles KW - Battery KW - Risk KW - Stone KW - Copyrights KW - Electric batteries KW - Nickel oxides KW - Animals KW - Inhalation KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743190028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Efficacy+of+Simple+Short-Term+in+Vitro+Assays+for+Predicting+the+Potential+of+Metal+Oxide+Nanoparticles+to+Cause+Pulmonary+Inflammation&rft.au=Lu%2C+Senlin%3BDuffin%2C+Rodger%3BPoland%2C+Craig%3BDaly%2C+Paul%3BMurphy%2C+Fiona%3BDrost%2C+Ellen%3BMacNee%2C+William%3BStone%2C+Vicki%3BDonaldson%2C+Ken&rft.aulast=Lu&rft.aufirst=Senlin&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Coal Use, Stove Improvement, and Adult Pneumonia Mortality in Xuanwei, China: A Retrospective Cohort Study AN - 743128814; 201004-31-0315057 (CE); 12126224 (EN) AB - BACKGROUND: In Xuanwei County, China, unvented indoor coal burning is strongly associated with increased risk of lung cancer and chronic obstructive pulmonary disease. However, the impact of coal burning and stove improvement on risk of pneumonia is not clear. METHODS: We conducted a retrospective cohort study among all farmers born 1917 through 1951 and living in Xuanwei as of 1 January 1976. The analysis included a total of 42,422 cohort members. Follow-up identified all deaths in the cohort from 1976 through 1996. Ages at entry into and at exit from follow-up ranged from 24 to 59 years and from 25 to 80 years, respectively. The record search detected 225 deaths from pneumonia, and 32,332 (76%) were alive as of 31 December 1996. We constructed multivariable Cox models (time variable = age) to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Use of coal, especially smokeless coal, was positively associated with pneumonia mortality. Annual tonnage and lifetime duration of smoky and smokeless coal use were positively associated with pneumonia mortality. Stove improvement was associated with a 50% reduction in pneumonia deaths (smoky coal users: HR, 0.521; 95% CI, 0.340-0.798; smokeless coal users: HR, 0.449; 95% CI, 0.215-0.937). CONCLUSIONS: Our analysis is the first to suggest that indoor air pollution from unvented coal burning is an important risk factor for pneumonia death in adults and that improving ventilation by installing a chimney is an effective measure to decrease it. JF - Environmental Health Perspectives AU - Shen, Min AU - Chapman, Robert S AU - Vermeulen, Roel AU - Tian, Linwei AU - Zheng, Tongzhang AU - Chen, Bingshu E AU - Engels, Eric A AU - He, Xingzhou AU - Blair, Aaron AU - Lan, Qing PY - 2009 SP - 261 EP - 266 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Coal KW - Pneumonia KW - Death KW - Combustion KW - Risk KW - Mortality KW - Stoves KW - Adults KW - Health KW - Mathematical models KW - Age KW - Searching KW - Reduction KW - Estimates KW - Indoor KW - Confidence intervals KW - Tonnage KW - Cancer KW - Hazards KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743128814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Coal+Use%2C+Stove+Improvement%2C+and+Adult+Pneumonia+Mortality+in+Xuanwei%2C+China%3A+A+Retrospective+Cohort+Study&rft.au=Shen%2C+Min%3BChapman%2C+Robert+S%3BVermeulen%2C+Roel%3BTian%2C+Linwei%3BZheng%2C+Tongzhang%3BChen%2C+Bingshu+E%3BEngels%2C+Eric+A%3BHe%2C+Xingzhou%3BBlair%2C+Aaron%3BLan%2C+Qing&rft.aulast=Shen&rft.aufirst=Min&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Cadmium Levels in Urine and Mortality among U.S. Adults AN - 743115493; 201004-31-0315067 (CE); 12126234 (EN) AB - BACKGROUND: Cadmium exposure has been associated with increased all-cause, cancer, and cardiovascular disease mortality. However, studies investigating this association have included participants with considerably higher levels of cadmium than those found in the general population. OBJECTIVE: We aimed to evaluate the association of creatinine-corrected urinary cadmium levels with all-cause and cause-specific mortality in the U.S. general population. METHODS: We analyzed the relationship between cadmium measured in 13,958 adults who participated in the Third National Health and Nutrition Examination Survey in 1988-1994 and were followed through 31 December 2000, and all-cause, cancer, cardiovascular disease, and coronary heart disease mortality. RESULTS: The geometric mean levels of urinary cadmium per gram of urinary creatinine in study participants were 0.28 and 0.40 microg/g for men and women, respectively (p 0.001). After multivariable adjustment, including smoking, a major source of cadmium exposure in nonoccupationally exposed populations, the hazard ratios [95% confidence interval (CI)] for all-cause, cancer, cardiovascular disease, and coronary heart disease mortality associated with a 2-fold higher creatinine-corrected urinary cadmium were, respectively, 1.28 (95% CI, 1.15-1.43), 1.55 (95% CI, 1.21-1.98), 1.21 (95% CI, 1.07-1.36), and 1.36 (95% CI, 1.11-1.66) for men and 1.06 (95% CI, 0.96-1.16), 1.07 (95% CI, 0.85-1.35), 0.93 (95% CI, 0.84-1.04), and 0.82 (95% CI, 0.76-0.89) for women. CONCLUSIONS: Environmental cadmium exposure was associated with an increased risk of all-cause, cancer, and cardiovascular disease mortality among men, but not among women. Additional efforts are warranted to fully explain gender differences on the impact of environmental cadmium exposure. JF - Environmental Health Perspectives AU - Menke, Andy AU - Muntner, Paul AU - Silbergeld, Ellen K AU - Platz, Elizabeth A AU - Guallar, Eliseo PY - 2009 SP - 190 EP - 196 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Cadmium KW - Mortality KW - Cancer KW - Health KW - Men KW - Heart diseases KW - Adults KW - Nutrition KW - Risk KW - Confidence intervals KW - Hazards KW - Environmental impact KW - Multivariable KW - Copyrights KW - Creatinine KW - Smoking KW - Urine KW - Exposure KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743115493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Cadmium+Levels+in+Urine+and+Mortality+among+U.S.+Adults&rft.au=Menke%2C+Andy%3BMuntner%2C+Paul%3BSilbergeld%2C+Ellen+K%3BPlatz%2C+Elizabeth+A%3BGuallar%2C+Eliseo&rft.aulast=Menke&rft.aufirst=Andy&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Bisphenol A at Low Nanomolar Doses Confers Chemoresistance in Estrogen Receptor-[alpha]-Positive and -Negative Breast Cancer Cells AN - 743105852; 201004-31-0314885 (CE); 12125208 (EN) AB - BACKGROUND: Resistance to chemotherapy is a major problem facing breast cancer patients, and identifying potential contributors to chemoresistance is a critical area of research. Bisphenol A (BPA) has long been suspected to promote carcinogenesis, but the high doses of BPA used in many studies generated conflicting results. In addition, the mechanism by which BPA exerts its biological actions is unclear. Although estrogen has been shown to antagonize anticancer drugs, the role of BPA in chemoresistance has not been examined. OBJECTIVE: The objective of our study was to determine whether BPA at low nanomolar concentrations opposes the action of doxorubicin, cisplatin, and vinblastine in the estrogen receptor-alpha (ERalpha)-positive T47D and the ERalpha-negative MDA-MB-468 breast cancer cells. METHODS: We determined the responsiveness of cells to anticancer drugs and BPA using the 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. Specific ERalpha and ERbeta inhibitors and real-time polymerase chain reaction were used to identify potential receptor(s) that mediate the actions of BPA. Expression of antiapoptotic proteins was assessed by Western blotting. RESULTS: BPA antagonizes the cytotoxicity of multiple chemotherapeutic agents in both ERalpha-positive and -negative breast cancer cells independent of the classical ERs. Both cell types express alternative ERs, including G-protein-coupled receptor 30 (GPR30) and members of the estrogen-related receptor family. Increased expression of antiapoptotic proteins is a potential mechanism by which BPA exerts its anticytotoxic effects. CONCLUSIONS: BPA at environmentally relevant doses reduces the efficacy of chemotherapeutic agents. These data provide considerable support to the accumulating evidence that BPA is hazardous to human health. JF - Environmental Health Perspectives AU - LaPensee, Elizabeth W AU - Tuttle, Traci R AU - Fox, Sejal R AU - Ben-Jonathan, Nira PY - 2009 SP - 175 EP - 180 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Nanostructure KW - Breast KW - Cancer KW - Estrogens KW - Health KW - Inhibitors KW - Bisphenol A KW - Nanomaterials KW - Drugs KW - Receptors KW - Proteins KW - Nanocomposites KW - Carcinogens KW - Chemotherapy KW - Patients KW - Biological KW - Doxorubicin KW - Polymerase chain reaction KW - Hazardous KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743105852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Bisphenol+A+at+Low+Nanomolar+Doses+Confers+Chemoresistance+in+Estrogen+Receptor-%5Balpha%5D-Positive+and+-Negative+Breast+Cancer+Cells&rft.au=LaPensee%2C+Elizabeth+W%3BTuttle%2C+Traci+R%3BFox%2C+Sejal+R%3BBen-Jonathan%2C+Nira&rft.aulast=LaPensee&rft.aufirst=Elizabeth&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The dependencies of phase velocity and dispersion on volume fraction in cancellous-bone-mimicking phantoms. AN - 742774915; pmid-19206892 AB - Frequency-dependent phase velocity was measured in eight cancellous-bone-mimicking phantoms consisting of suspensions of randomly oriented nylon filaments (simulating trabeculae) in a soft-tissue-mimicking medium (simulating marrow). Trabecular thicknesses ranged from 152 to 356 mum. Volume fractions of nylon filament material ranged from 0% to 10%. Phase velocity varied approximately linearly with frequency over the range from 300 to 700 kHz. The increase in phase velocity (compared with phase velocity in a phantom containing no filaments) at 500 kHz was approximately proportional to volume fraction occupied by nylon filaments. The derivative of phase velocity with respect to frequency was negative and exhibited nonlinear, monotonically decreasing dependence on volume fraction. The dependencies of phase velocity and its derivative on volume fraction in these phantoms were similar to those reported in previous studies on (1) human cancellous bone and (2) phantoms consisting of parallel nylon wires immersed in water. JF - The Journal of the Acoustical Society of America AU - Wear, Keith A AD - US Food and Drug Administration, Center for Devices and Radiological Health, HFZ-142, Rockville, Maryland 20852, USA. keith.wear@fda.hhs.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 1197 EP - 1201 VL - 125 IS - 2 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Equipment Design KW - Image Interpretation, Computer-Assisted KW - Humans KW - Nylons KW - Phantoms, Imaging KW - Bone Marrow -- ultrasonography KW - Ultrasonography -- instrumentation KW - Bone and Bones -- ultrasonography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742774915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=The+dependencies+of+phase+velocity+and+dispersion+on+volume+fraction+in+cancellous-bone-mimicking+phantoms.&rft.au=Wear%2C+Keith+A&rft.aulast=Wear&rft.aufirst=Keith&rft.date=2009-02-01&rft.volume=125&rft.issue=2&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Fluorogold induces persistent neurological deficits and circling behavior in mice over-expressing human mutant tau. AN - 67127670; 19355926 AB - An increasing number of applications use nanospecie-fluorescent labeling technology; however, no established guidelines are available to warrant their safety for potential clinical use. Here, rTg4510 transgenic mice and their littermate controls were injected with fluorogold, a nanospecie tracer, or phosphate buffered saline (PBS) targeted to the right amygdala. No significant abnormal behavior was detected in any mice injected with PBS. After fluorogold injection, however, rTg4510 mice displayed persistent left-sided neurological deficits and left circling behavior for up to 14 days post-injection, while control mice demonstrated a transient syndrome. Mortality occurred only in rTg4510 mice and statistically significant differences appeared independent of age. An immunofluorescent study revealed TUNEL positive cells that were heavily and extensively distributed in the periamygdalar region that overlapped with the fluorogold deposit region in rTg4510 mice, whereas control mice showed only sporadic distribution of TUNEL-positive cells. Co-localization of TUNEL and caspase-3 active peptide immunoreactivity was identified in a subset of the cells, indicating an involvement of caspase-dependent apoptotic mechanisms. In conclusion, fluorogold induces damage in the central nervous system most noticeably in mice over-expressing human mutant tau. JF - Current neurovascular research AU - He, Zhen AD - Department of Neuroscience, Division of Neurotoxicology, NCTR, Food and Drug Administration, Mayo Clinic Jacksonville, USA. Zhen.He@fda.hhs.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 54 EP - 61 VL - 6 IS - 1 KW - 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt KW - 0 KW - Fluorescent Dyes KW - Indoles KW - MAPT protein, human KW - Stilbamidines KW - tau Proteins KW - DAPI KW - 47165-04-8 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Animals KW - Age Factors KW - Humans KW - Mutation -- genetics KW - Mice KW - Fluorescent Dyes -- toxicity KW - Mice, Transgenic KW - Statistics, Nonparametric KW - Behavior, Animal KW - In Situ Nick-End Labeling -- methods KW - Caspase 3 -- metabolism KW - Stereotyped Behavior -- physiology KW - Stilbamidines -- toxicity KW - Nervous System Diseases -- mortality KW - tau Proteins -- genetics KW - Gene Expression KW - Stereotyped Behavior -- drug effects KW - Nervous System Diseases -- genetics KW - Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67127670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+neurovascular+research&rft.atitle=Fluorogold+induces+persistent+neurological+deficits+and+circling+behavior+in+mice+over-expressing+human+mutant+tau.&rft.au=He%2C+Zhen&rft.aulast=He&rft.aufirst=Zhen&rft.date=2009-02-01&rft.volume=6&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Current+neurovascular+research&rft.issn=1875-5739&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-25 N1 - Date created - 2009-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational exposure to polychlorinated biphenyls and risk of breast cancer. AN - 67001560; 19270799 AB - Despite the endocrine system activity exhibited by polychlorinated biphenyls (PCBs), recent studies have shown little association between PCB exposure and breast cancer mortality. To further evaluate the relation between PCB exposure and breast cancer risk, we studied incidence, a more sensitive end point than mortality, in an occupational cohort. We followed 5,752 women employed for at least 1 year in one of three capacitor manufacturing facilities, identifying cases from questionnaires, cancer registries, and death certificates through 1998. We collected lifestyle and reproductive information via questionnaire from participants or next of kin and used semiquantitative job-exposure matrices for inhalation and dermal exposures combined. We generated standardized incidence ratios (SIRs) and standardized rate ratios and used Cox proportional hazards regression models to evaluate potential confounders and effect modifiers. Overall, the breast cancer SIR was 0.81 (95% confidence interval, 0.72-0.92; n = 257), and regression modeling showed little effect of employment duration or cumulative exposure. However, for the 362 women of questionnaire-identified races other than white, we observed positive, statistically significant associations with employment duration and cumulative exposure; only smoking, birth cohort, and self- or proxy questionnaire completion had statistically significant explanatory power when added to models with exposure metrics. We found no overall elevation in breast cancer risk after occupational exposure to PCBs. However, the exposure-related risk elevations seen among nonwhite workers, although of limited interpretability given the small number of cases, warrant further investigation, because the usual reproductive risk factors accounted for little of the increased risk. JF - Environmental health perspectives AU - Silver, Sharon R AU - Whelan, Elizabeth A AU - Deddens, James A AU - Steenland, N Kyle AU - Hopf, Nancy B AU - Waters, Martha A AU - Ruder, Avima M AU - Prince, Mary M AU - Yong, Lee C AU - Hein, Misty J AU - Ward, Elizabeth M AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio 45226, USA. SSilver@cdc.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 276 EP - 282 VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - occupational epidemiology KW - breast cancer KW - polychlorinated biphenyls KW - incidence KW - Risk Factors KW - Humans KW - Surveys and Questionnaires KW - Female KW - Occupational Exposure -- adverse effects KW - Breast Neoplasms -- epidemiology KW - Polychlorinated Biphenyls -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67001560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Occupational+exposure+to+polychlorinated+biphenyls+and+risk+of+breast+cancer.&rft.au=Silver%2C+Sharon+R%3BWhelan%2C+Elizabeth+A%3BDeddens%2C+James+A%3BSteenland%2C+N+Kyle%3BHopf%2C+Nancy+B%3BWaters%2C+Martha+A%3BRuder%2C+Avima+M%3BPrince%2C+Mary+M%3BYong%2C+Lee+C%3BHein%2C+Misty+J%3BWard%2C+Elizabeth+M&rft.aulast=Silver&rft.aufirst=Sharon&rft.date=2009-02-01&rft.volume=117&rft.issue=2&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11774 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-31 N1 - Date created - 2009-03-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Ind Med. 1998 Nov;34(5):517-8 [9787858] Am J Epidemiol. 1992 Aug 15;136(4):389-98 [1415158] Breast Cancer Res. 2005;7(1):R12-8 [15642161] Epidemiology. 2006 Jan;17(1):8-13 [16357589] Environ Health Perspect. 2006 Jan;114(1):18-23 [16393652] J Clin Pharmacol. 2006 Apr;46(4):405-7 [16554447] Environ Health Perspect. 2006 Jul;114(7):1092-8 [16835064] Environ Health. 2006;5:13 [16716225] J Natl Cancer Inst Monogr. 2006;(36):19-25 [17032890] Environ Health Perspect. 2006 Oct;114(10):1508-14 [17035134] Toxicology. 2001 Feb 14;158(3):141-53 [11275356] Toxicol Sci. 2002 Oct;69(2):362-72 [12377985] J Occup Environ Med. 2003 Mar;45(3):271-82 [12661184] Eur J Cancer Prev. 2003 Dec;12(6):509-16 [14639129] Breast Cancer Res. 2004;6(4):R460-73 [15217514] Nat Rev Cancer. 2004 Jul;4(7):519-27 [15229477] Toxicol In Vitro. 2004 Dec;18(6):811-9 [15465647] Arch Environ Health. 1981 May-Jun;36(3):120-9 [6787990] Am J Epidemiol. 1986 Mar;123(3):481-9 [3946394] Arch Environ Health. 1987 Nov-Dec;42(6):333-9 [3125795] J Occup Med. 1988 Apr;30(4):348-53 [3379489] J Clin Epidemiol. 1991;44(1):29-39 [1986055] J Occup Environ Med. 1999 Mar;41(3):161-71 [10091139] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.11774 ER - TY - JOUR T1 - Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. AN - 66987514; 19193781 AB - The purpose of the present application was to fulfill a postmarketing commitment to provide long-term efficacy and safety data on treatment with imatinib mesylate (Gleevec; Novartis Pharmaceuticals, East Hanover, NJ) in patients with CD117(+) unresectable and/or metastatic malignant gastrointestinal stromal tumors (GISTs). In addition, this application also provides evidence to support a change in the label to allow for an escalation of imatinib dosing to 800 mg/day for patients with progressive disease on a lower dose. Two open-label, controlled, multicenter, intergroup, international, randomized phase III studies were submitted -- one conducted by the European Organization for Research and Treatment of Cancer (n = 946) and the other by the Southwest Oncology Group (n = 746). These studies compared 400 mg/day of imatinib with 800 mg/day of imatinib. A combined analysis of the two studies was prospectively defined and agreed to by both groups. Both protocols allowed patients randomized to the 400-mg/day imatinib arm to cross over to 800 mg/day imatinib at progression. Objective responses were achieved in >50% of patients receiving either imatinib dose. The median progression-free survival time was approximately 20 months and the median overall survival (OS) time was approximately 49 months. In the combined analysis, 347 patients crossed over to 800 mg/day imatinib at the time of progression. The median OS time after crossover was 14.3 months. The most common adverse events (AEs) were fluid retention, nausea, fatigue, skin rash, gastrointestinal complaints, and myalgia. The most common laboratory abnormality was anemia. Most often the AEs were of mild-to-moderate severity. Fluid retention events and skin rash were numerically reported more often in the 800-mg/day treatment cohort of patients. JF - The oncologist AU - Cohen, Martin H AU - Farrell, Ann AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993-0002, USA. martin.cohen@fda.hhs.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 174 EP - 180 VL - 14 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Benzamides KW - Piperazines KW - Pyrimidines KW - Imatinib Mesylate KW - 8A1O1M485B KW - Index Medicus KW - Young Adult KW - Disease-Free Survival KW - Aged, 80 and over KW - Humans KW - Drug Approval KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Pyrimidines -- adverse effects KW - Pyrimidines -- therapeutic use KW - Piperazines -- therapeutic use KW - Gastrointestinal Stromal Tumors -- drug therapy KW - Piperazines -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66987514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Approval+summary%3A+imatinib+mesylate+in+the+treatment+of+metastatic+and%2For+unresectable+malignant+gastrointestinal+stromal+tumors.&rft.au=Cohen%2C+Martin+H%3BFarrell%2C+Ann%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Cohen&rft.aufirst=Martin&rft.date=2009-02-01&rft.volume=14&rft.issue=2&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2008-0255 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2008-0255 ER - TY - JOUR T1 - Effect of short-term exposure to zidovudine (AZT) on the expression of mitochondria-related genes in skeletal muscle of neonatal mice. AN - 66952986; 18824140 AB - Zidovudine (3'-azido-3'-deoxythymidine; AZT) is the main anti-retroviral drug given to HIV-1-infected pregnant women during pregnancy and to their infants after birth to reduce mother-to-child transmission of the virus. In animal studies, however, a significant mitochondrial morphological damage has been reported in skeletal muscle as a consequence of transplacental or perinatal exposure to AZT. Because proper muscle function is highly dependent on efficient mitochondrial function and information on AZT-induced mitochondrial toxicity during neonatal exposure is limited, we investigated the effect of AZT on the expression of 542 mitochondria-related genes encoded by both nuclear and mitochondrial DNA in the skeletal muscle of infant male and female mice using microarray technology. Animals were treated orally by gavage with AZT at 0, 10, 50, 100, and 200mg/kg body weight/day from postnatal day (PND) 1 through 8 and were sacrificed at 1- and 2-h following the last dose on PND 8. These doses in mice correspond to 0, 1.1, 5.5, 11.0, and 22.0mg/kg AZT in human infants [Center for Drug Evaluation and Research (CDER) 2005. Pharmacology and Toxicology, Guidance for industry. Estimating the maximum safe dose in initial clinical trials for therapeutics in adult healthy volunteers, p. 7. http://www.fda.gov/cder/guidance/index.htm.]. Microarray data were analyzed for effects of time, sex, treatment, and their interactions using a fixed effect linear model. The results showed modest, but significant, dose-related responses in the expression level of genes associated with apoptosis, fatty acid metabolism, mitochondrial DNA maintenance, and various mitochondrial membrane transporters. The transcription levels were not significantly different at both time points and were not sex dependent. The results suggest that changes in expression of mitochondria-related genes in skeletal muscle may be an initial response to short-term AZT exposure in infant mice. JF - Mitochondrion AU - Desai, Varsha G AU - Lee, Taewon AU - Moland, Carrie L AU - Branham, William S AU - Von Tungeln, Linda S AU - Beland, Frederick A AU - Fuscoe, James C AD - Center for Functional Genomics, Division of Systems Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. varsha.desai@fda.hhs.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 9 EP - 16 VL - 9 IS - 1 SN - 1567-7249, 1567-7249 KW - DNA, Mitochondrial KW - 0 KW - Reverse Transcriptase Inhibitors KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - Animals KW - Apoptosis KW - Sex Factors KW - DNA, Mitochondrial -- metabolism KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Mice KW - Time Factors KW - Male KW - Female KW - Reverse Transcriptase Inhibitors -- pharmacology KW - Zidovudine -- pharmacology KW - Mitochondria -- metabolism KW - Gene Expression Regulation KW - Muscle, Skeletal -- metabolism KW - Muscle, Skeletal -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66952986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mitochondrion&rft.atitle=Effect+of+short-term+exposure+to+zidovudine+%28AZT%29+on+the+expression+of+mitochondria-related+genes+in+skeletal+muscle+of+neonatal+mice.&rft.au=Desai%2C+Varsha+G%3BLee%2C+Taewon%3BMoland%2C+Carrie+L%3BBranham%2C+William+S%3BVon+Tungeln%2C+Linda+S%3BBeland%2C+Frederick+A%3BFuscoe%2C+James+C&rft.aulast=Desai&rft.aufirst=Varsha&rft.date=2009-02-01&rft.volume=9&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Mitochondrion&rft.issn=15677249&rft_id=info:doi/10.1016%2Fj.mito.2008.09.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-08 N1 - Date created - 2009-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mito.2008.09.002 ER - TY - JOUR T1 - Silicosis in lymph nodes: the canary in the miner? AN - 66915014; 19209037 AB - To investigate evidence that lymph node silicosis can precede parenchymal silicosis. The study population was comprised of 264 deceased male uranium miners for whom two or more of four pathologists agreed on the presence or absence of silicosis in lymph nodes and lung parenchyma. We had work histories and silica exposure estimates. Twenty percent of the miners had lymph node silicosis only, 4% had parenchymal silicosis only, and 39% had both. Silica exposure was lower for miners with lymph node silicosis only than for those with both lymph node and parenchymal silicosis. Lymph node silicosis was associated with parenchymal silicosis after adjustment for silica exposure. Our results are consistent with silicosis potentially occurring in lymph nodes before the parenchyma. Lymph node damage could impair silica clearance and increase the risk for parenchymal silicosis. JF - Journal of occupational and environmental medicine AU - Cox-Ganser, Jean M AU - Burchfiel, Cecil M AU - Fekedulegn, Desta AU - Andrew, Michael E AU - Ducatman, Barbara S AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA. jjc8@cdc.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 164 EP - 169 VL - 51 IS - 2 KW - Uranium KW - 4OC371KSTK KW - Index Medicus KW - Cadaver KW - Humans KW - Germany -- epidemiology KW - Male KW - Silicosis -- pathology KW - Lymph Nodes -- pathology KW - Occupational Exposure -- adverse effects KW - Silicosis -- epidemiology KW - Mining KW - Silicosis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66915014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Silicosis+in+lymph+nodes%3A+the+canary+in+the+miner%3F&rft.au=Cox-Ganser%2C+Jean+M%3BBurchfiel%2C+Cecil+M%3BFekedulegn%2C+Desta%3BAndrew%2C+Michael+E%3BDucatman%2C+Barbara+S&rft.aulast=Cox-Ganser&rft.aufirst=Jean&rft.date=2009-02-01&rft.volume=51&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=1536-5948&rft_id=info:doi/10.1097%2FJOM.0b013e31818f6a0f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-18 N1 - Date created - 2009-02-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 2003 Feb 15;157(4):364-75 [12578807] Arch Pathol Lab Med. 1988 Jul;112(7):673-720 [2838005] Occup Environ Med. 1998 Jun;55(6):383-6 [9764097] Am J Ind Med. 1996 Nov;30(5):529-39 [8909602] Thorax. 1996 Nov;51(11):1165-7 [8958905] Br J Ind Med. 1991 Apr;48(4):267-9 [2025593] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JOM.0b013e31818f6a0f ER - TY - JOUR T1 - Continued participation in an asbestos fiber-counting proficiency test with relocatable grid slides. AN - 66914983; 19212603 AB - The effect of using relocatable reference slides of chrysotile and amosite in asbestos fiber counting proficiency testing was examined for volunteer analysts from laboratories in the USA. Results of participation in one round have been published; two more rounds are reported here. In the first round, participants were asked to draw what they saw, allowing identification of error type by comparison to the reference. In later rounds only the number of fibers per field was reported since the number of errors per field has been shown to be a reasonable estimate of proficiency. The third round included a training exercise. The total number of participants stayed reasonably constant with some reduction over time. More restricted numbers participated from round to round. Those who dropped out had lower average scores than those that remained in the program; from 2006 to 2007 this difference was significant, but for 2007 to 2008 it was not. The overall results for amosite were generally good compared to an arbitrary proficiency score of 60, and continued to improve further over time. The results for chrysotile were better in rounds 1 and 3 than round 2, so that both attention to detail (drawing the fibers in round 1) and training (round 3) may improve performance, which is consistent with the major type of error being oversight of fine fibers. However, the results are still poor, even by round 3, and no analyst achieved a score of 60 in all three rounds. Further improvement is preferred since chrysotile is the most commonly encountered type of asbestos in the USA. Depending on the adopted score for proficiency many laboratories or analysts may be labeled as poor performers and this may be a deterrent to voluntary participation in this type of exercise, especially for those in most need of assistance. Participants have tested new relocatable reference asbestos proficiency counting slides in three rounds of chrysotile and three rounds of amosite. Performance for amosite was good. Poor performance for chrysotile appears to be improved by greater attention and training. JF - Journal of environmental monitoring : JEM AU - Harper, Martin AU - Slaven, James E AU - Pang, Thomas W S AD - National Institute for Occupational Safety and Health, Exposure Assessment Branch, Health Effects Laboratory Division, 1095 Willowdale Rd, MS-3030, Morgantown, WV 26505, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 434 EP - 438 VL - 11 IS - 2 KW - Asbestos, Serpentine KW - 0 KW - Asbestos, Amosite KW - 12172-73-5 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - United States KW - Humans KW - Asbestos, Amosite -- analysis KW - Reference Standards KW - Asbestos, Serpentine -- analysis KW - Laboratories -- standards KW - Asbestos -- analysis KW - Microscopy -- methods KW - Microscopy -- standards KW - Environmental Monitoring -- standards KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66914983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Continued+participation+in+an+asbestos+fiber-counting+proficiency+test+with+relocatable+grid+slides.&rft.au=Harper%2C+Martin%3BSlaven%2C+James+E%3BPang%2C+Thomas+W+S&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2009-02-01&rft.volume=11&rft.issue=2&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=1464-0333&rft_id=info:doi/10.1039%2Fb813893a LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-28 N1 - Date created - 2009-02-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Environ Monit. 2009 Feb;11(2):434 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/b813893a ER - TY - JOUR T1 - Hexavalent chromium content in stainless steel welding fumes is dependent on the welding process and shield gas type. AN - 66914528; 19212602 AB - Occupational exposure to welding fumes is a known health hazard. To isolate elements in stainless steel welding fumes with high potential for adverse health outcomes, fumes were generated using a robotic gas metal arc system, using four shield gases of varying oxygen content. The objective was to measure Cr(VI) concentrations in a broad spectrum of gas metal arc welding processes, and identify processes of exceptionally high or low Cr(VI) content. The gases used were 95% Ar/5% O(2), 98% Ar/2% O(2), 95% Ar/5%CO(2), and 75% He/25% Ar. The welder was operated in axial spray mode (Ar/O(2), Ar/CO(2)), short-circuit (SC) mode (Ar/CO(2) low voltage and He/Ar), and pulsed axial-spray mode (98% Ar/2% O(2)). Results indicate large differences in Cr(VI) in the fumes, with Ar/O(2) (Pulsed)>Ar/O(2)>Ar/CO(2)>Ar/CO(2) (SC)>He/Ar; values were 3000+/-300, 2800+/-85, 2600+/-120, 1400+/-190, and 320+/-290 ppm respectively (means +/- standard errors for 2 runs and 3 replicates per run). Respective rates of Cr(VI) generation were 1.5, 3.2, 4.4, 1.3, and 0.46 microg/min; generation rates were also calculated in terms of microg Cr(VI) per metre of wire used. The generation rates of Cr(VI) increased with increasing O(3) concentrations. Particle size measurements indicated similar distributions, but somewhat higher >0.6 microm fractions for the short-circuit mode samples. Fumes were also sampled into 2 selected size ranges, a microspatter fraction (>or=0.6 microm) and a fine (<0.6 microm) fraction; analysis indicated that Cr(VI) is primarily associated with particles <0.6 microm. The conclusion of the study is that Cr(VI) concentrations vary significantly with welding type and shield gas type, and this presents an opportunity to tailor welding practices to lessen Cr(VI) exposures in workplaces by selecting low Cr(VI)-generating processes. Short-circuit processes generated less Cr(VI) than axial-spray methods, and inert gas shielding gave lower Cr(VI) content than shielding with active gases. A short circuit He/Ar shielded process and a pulsed axial spray Ar/O(2) process were both identified as having substantially lower Cr(VI) generation rates per unit of wire used relative to the other processes studied. JF - Journal of environmental monitoring : JEM AU - Keane, Michael AU - Stone, Samuel AU - Chen, Bean AU - Slaven, James AU - Schwegler-Berry, Diane AU - Antonini, James AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Rd, Morgantown, WV 26505, USA. mjk3@cdc.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 418 EP - 424 VL - 11 IS - 2 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Carcinogens, Environmental KW - Gases KW - Chromium KW - 0R0008Q3JB KW - Stainless Steel KW - 12597-68-1 KW - chromium hexavalent ion KW - 18540-29-9 KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Aerosols -- analysis KW - Particle Size KW - Humans KW - Time Factors KW - Ozone -- chemistry KW - Welding -- methods KW - Gases -- analysis KW - Chromium -- analysis KW - Air Pollutants, Occupational -- analysis KW - Carcinogens, Environmental -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66914528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Hexavalent+chromium+content+in+stainless+steel+welding+fumes+is+dependent+on+the+welding+process+and+shield+gas+type.&rft.au=Keane%2C+Michael%3BStone%2C+Samuel%3BChen%2C+Bean%3BSlaven%2C+James%3BSchwegler-Berry%2C+Diane%3BAntonini%2C+James&rft.aulast=Keane&rft.aufirst=Michael&rft.date=2009-02-01&rft.volume=11&rft.issue=2&rft.spage=418&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=1464-0333&rft_id=info:doi/10.1039%2Fb814063d LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-28 N1 - Date created - 2009-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/b814063d ER - TY - JOUR T1 - Evaluation of sequential extraction procedures for soluble and insoluble hexavalent chromium compounds in workplace air samples. AN - 66913978; 19212588 AB - Because toxicities may differ for Cr(VI) compounds of varying solubility, some countries and organizations have promulgated different occupational exposure limits (OELs) for soluble and insoluble hexavalent chromium (Cr(VI)) compounds, and analytical methods are needed to determine these species in workplace air samples. To address this need, international standard methods ASTM D6832 and ISO 16740 have been published that describe sequential extraction techniques for soluble and insoluble Cr(VI) in samples collected from occupational settings. However, no published performance data were previously available for these Cr(VI) sequential extraction procedures. In this work, the sequential extraction methods outlined in the relevant international standards were investigated. The procedures tested involved the use of either deionized water or an ammonium sulfate/ammonium hydroxide buffer solution to target soluble Cr(VI) species. This was followed by extraction in a sodium carbonate/sodium hydroxide buffer solution to dissolve insoluble Cr(VI) compounds. Three-step sequential extraction with (1) water, (2) sulfate buffer and (3) carbonate buffer was also investigated. Sequential extractions were carried out on spiked samples of soluble, sparingly soluble and insoluble Cr(VI) compounds, and analyses were then generally carried out by using the diphenylcarbazide method. Similar experiments were performed on paint pigment samples and on airborne particulate filter samples collected from stainless steel welding. Potential interferences from soluble and insoluble Cr(III) compounds, as well as from Fe(II), were investigated. Interferences from Cr(III) species were generally absent, while the presence of Fe(II) resulted in low Cr(VI) recoveries. Two-step sequential extraction of spiked samples with (first) either water or sulfate buffer, and then carbonate buffer, yielded quantitative recoveries of soluble Cr(VI) and insoluble Cr(VI), respectively. Three-step sequential extraction gave excessively high recoveries of soluble Cr(VI), low recoveries of sparingly soluble Cr(VI), and quantitative recoveries of insoluble Cr(VI). Experiments on paint pigment samples using two-step extraction with water and carbonate buffer yielded varying percentages of relative fractions of soluble and insoluble Cr(VI). Sequential extractions of stainless steel welding fume air filter samples demonstrated the predominance of soluble Cr(VI) compounds in such samples. The performance data obtained in this work support the Cr(VI) sequential extraction procedures described in the international standards. JF - Journal of environmental monitoring : JEM AU - Ashley, Kevin AU - Applegate, Gregory T AU - Marcy, A Dale AU - Drake, Pamela L AU - Pierce, Paul A AU - Carabin, Nathalie AU - Demange, Martine AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mail Stop R-7, Cincinnati, OH 45226-1998, USA. KAshley@cdc.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 318 EP - 325 VL - 11 IS - 2 KW - Air Pollutants, Occupational KW - 0 KW - Carbonates KW - Hydroxides KW - Water KW - 059QF0KO0R KW - Chromium KW - 0R0008Q3JB KW - chromium hexavalent ion KW - 18540-29-9 KW - sodium carbonate KW - 45P3261C7T KW - Ammonium Hydroxide KW - 5138Q19F1X KW - Sodium Hydroxide KW - 55X04QC32I KW - Ammonium Sulfate KW - SU46BAM238 KW - Index Medicus KW - Sensitivity and Specificity KW - Carbonates -- chemistry KW - Filtration -- methods KW - Solubility KW - Paint -- analysis KW - Water -- chemistry KW - Hydroxides -- chemistry KW - Sodium Hydroxide -- chemistry KW - Ammonium Sulfate -- chemistry KW - Chromium -- chemistry KW - Chromium -- analysis KW - Air Pollutants, Occupational -- analysis KW - Chemical Fractionation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66913978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Measuring+Hospital+Inefficiency%3A+The+Effects+of+Controlling+for+Quality+and+Patient+Burden+of+Illness&rft.au=Mutter%2C+Ryan+L%3BRosko%2C+Michael+D%3BWong%2C+Herbert+S&rft.aulast=Mutter&rft.aufirst=Ryan&rft.date=2008-12-01&rft.volume=43&rft.issue=6&rft.spage=1992&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2008.00892.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-28 N1 - Date created - 2009-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/b812236a ER - TY - JOUR T1 - Respiratory morbidity and medical visits associated with dampness and air-conditioning in offices and homes. AN - 66887182; 19076249 AB - We used data from 4345 adult US residents who were part of a 2004 national random mail survey to investigate associations between dampness and air-conditioning (AC) in homes and offices, and health outcomes, sick leave due to respiratory symptoms and medical visits during the past 12 months. We identified from this group 1396 office workers employed in professional, executive, administrative, managerial or administrative support occupations. Office workers reporting home dampness had an elevated prevalence of nasal symptoms [prevalence ratio (PR) = 1.4, P = 0.01] and constitutional symptoms (PR = 1.3, P = 0.01) in the previous year. Office workers reporting workplace dampness had an elevated prevalence of sick leave attributed to respiratory symptoms (PR = 1.3, P = 0.04) in the previous year. Office workers with home AC were more likely to have visited a medical specialist in the previous year (PR = 1.3, P = 0.02). We did not find any statistically significant associations between workplace AC and any of the health outcomes. We estimated an annual cost of US$1.4 billion for excess respiratory-related sick leave among office workers with workplace dampness. Our study strengthens the evidence of a relationship between dampness and health effects, and highlights the resulting economic impact. This study adds to the literature on respiratory morbidity associated with home and office exposures to mold and dampness. Public health response to lessen these exposures will improve the health and well-being of residents and workers as well as diminish the economic burden of lost work time and medical costs. JF - Indoor air AU - Sahakian, N AU - Park, J-H AU - Cox-Ganser, J AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA. nsahakian@cdc.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 58 EP - 67 VL - 19 IS - 1 KW - Index Medicus KW - Young Adult KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Office Visits -- statistics & numerical data KW - Air Pollution, Indoor -- adverse effects KW - Respiratory Tract Diseases -- economics KW - Air Pollution, Indoor -- economics KW - Respiratory Tract Diseases -- etiology KW - Humidity -- adverse effects KW - Respiratory Tract Diseases -- epidemiology KW - Air Conditioning -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66887182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Evaluation+of+a+comprehensive+slip%2C+trip+and+fall+prevention+programme+for+hospital+employees&rft.au=Bell%2C+Jennifer%3BCollins%2C+James%3BWolf%2C+Laurie%3BGronqvist%2C+Raoul%3BChiou%2C+Sharon%3BChang%2C+Wen-Ruey%3BSorock%2C+Gary%3BCourtney%2C+Theodore%3BLombardi%2C+David%3BEvanoff%2C+Bradley&rft.aulast=Bell&rft.aufirst=Jennifer&rft.date=2008-12-01&rft.volume=51&rft.issue=12&rft.spage=1906&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130802248092 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-20 N1 - Date created - 2009-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0668.2008.00561.x ER - TY - JOUR T1 - A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma. AN - 66885546; 19029192 AB - Toll-like receptors (TLRs) may influence the development of non-Hodgkin lymphoma (NHL) given their important roles in recognizing microbial pathogens and stimulating multiple immune pathways. We conducted an investigation of TLR gene variants in a pooled analysis including three population-based case-control studies of NHL (1946 cases and 1808 controls). Thirty-six tag single-nucleotide polymorphisms (SNPs) in TLR2, TLR4 and the TLR10-TLR1-TLR6 gene cluster were genotyped. Two TLR10-TLR1-TLR6 variants in moderate linkage disequilibrium were significantly associated with NHL: rs10008492 [odds ratio for CT genotype (OR(CT)) 1.12, 95% confidence interval (CI) 0.97-1.30; OR(TT) 1.40, 95% CI 1.15-1.71; P(trend) = 0.001] and rs4833103 (OR(AC) 0.75, 95% CI 0.64-0.88; OR(AA) 0.74, 95% CI 0.62-0.90; P(trend) = 0.002; P(dominant) = 0.0002). Associations with these SNPs were consistent across all the three studies and did not appreciably differ by histologic subtype. We found little evidence of association between TLR2 variation and all NHL, although the rare variant rs3804100 was significantly associated with marginal zone lymphoma (MZL), both overall (OR(CT/CC) 1.89, 95% CI 1.27-2.81; P(dominant) = 0.002) and in two of the three studies. No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL. JF - Carcinogenesis AU - Purdue, Mark P AU - Lan, Qing AU - Wang, Sophia S AU - Kricker, Anne AU - Menashe, Idan AU - Zheng, Tong-Zhang AU - Hartge, Patricia AU - Grulich, Andrew E AU - Zhang, Yawei AU - Morton, Lindsay M AU - Vajdic, Claire M AU - Holford, Theodore R AU - Severson, Richard K AU - Leaderer, Brian P AU - Cerhan, James R AU - Yeager, Meredith AU - Cozen, Wendy AU - Jacobs, Kevin AU - Davis, Scott AU - Rothman, Nathaniel AU - Chanock, Stephen J AU - Chatterjee, Nilanjan AU - Armstrong, Bruce K AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA. purduem@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 275 EP - 281 VL - 30 IS - 2 KW - Toll-Like Receptors KW - 0 KW - Index Medicus KW - Risk KW - Polymorphism, Single Nucleotide KW - Aged, 80 and over KW - Multigene Family KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Linkage Disequilibrium KW - Male KW - Female KW - Lymphoma, Non-Hodgkin -- genetics KW - Toll-Like Receptors -- genetics KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66885546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=A+pooled+investigation+of+Toll-like+receptor+gene+variants+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Purdue%2C+Mark+P%3BLan%2C+Qing%3BWang%2C+Sophia+S%3BKricker%2C+Anne%3BMenashe%2C+Idan%3BZheng%2C+Tong-Zhang%3BHartge%2C+Patricia%3BGrulich%2C+Andrew+E%3BZhang%2C+Yawei%3BMorton%2C+Lindsay+M%3BVajdic%2C+Claire+M%3BHolford%2C+Theodore+R%3BSeverson%2C+Richard+K%3BLeaderer%2C+Brian+P%3BCerhan%2C+James+R%3BYeager%2C+Meredith%3BCozen%2C+Wendy%3BJacobs%2C+Kevin%3BDavis%2C+Scott%3BRothman%2C+Nathaniel%3BChanock%2C+Stephen+J%3BChatterjee%2C+Nilanjan%3BArmstrong%2C+Bruce+K&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2009-02-01&rft.volume=30&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn262 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-26 N1 - Date created - 2009-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2449-53 [16214931] J Immunol. 2005 Aug 15;175(4):2534-40 [16081826] Ann N Y Acad Sci. 2005 Dec;1062:95-103 [16461792] Blood. 2006 May 15;107(10):4101-8 [16449530] Br J Haematol. 2006 Jul;134(2):180-3 [16740140] Genet Epidemiol. 2006 Sep;30(6):495-507 [16755536] Cancer Res. 2006 Oct 1;66(19):9771-80 [17018637] Genes Immun. 2006 Dec;7(8):615-24 [16971956] Rev Med Virol. 2007 Jan-Feb;17(1):35-43 [17146842] Arthritis Rheum. 2007 Feb 15;57(1):161-70 [17266090] Carcinogenesis. 2007 Mar;28(3):704-12 [17056605] J Immunol. 2007 May 15;178(10):6387-94 [17475868] Hum Mol Genet. 2007 May 15;16(10):1225-32 [17409197] J Immunol. 2007 Jun 15;178(12):7520-4 [17548585] Blood. 2007 Jul 15;110(2):695-708 [17389762] Eur J Immunol. 2007 Aug;37(8):2280-9 [17595679] Int Immunopharmacol. 2007 Oct;7(10):1271-85 [17673142] Crit Rev Oncol Hematol. 2007 Sep;63(3):245-56 [17583528] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):1982-9 [17932345] J Infect Dis. 2008 Jan 15;197(2):253-61 [18177245] J Allergy Clin Immunol. 2008 Apr;121(4):1013-9 [18234309] Blood. 2007 Dec 15;110(13):4455-63 [17827388] Hum Pathol. 2000 Feb;31(2):263-8 [10685647] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):687-96 [11401920] Methods Mol Biol. 2002;184:143-68 [11889711] Nat Med. 2002 Aug;8(8):878-84 [12091878] Blood. 2003 Aug 1;102(3):956-63 [12689944] J Biol Chem. 2003 Aug 29;278(35):32552-60 [12807870] Hum Hered. 2003;56(1-3):18-31 [14614235] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Am J Epidemiol. 2004 Jan 15;159(2):148-54 [14718216] N Engl J Med. 2004 Jan 15;350(3):239-48 [14724303] Ann Oncol. 2004 Apr;15(4):631-7 [15033672] Int J Cancer. 2004 Jun 20;110(3):429-34 [15095310] Genes Immun. 2004 Aug;5(5):343-6 [15266299] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1415-21 [15342441] Am J Respir Crit Care Med. 2004 Sep 15;170(6):594-600 [15201134] J Am Acad Dermatol. 1991 Apr;24(4):584-90 [2033136] Lancet. 1993 Sep 4;342(8871):571-4 [8102718] Yale J Biol Med. 1996 Jan-Feb;69(1):61-8 [9041690] Gastroenterology. 2004 Nov;127(5):1513-24 [15521019] Eur J Gastroenterol Hepatol. 2004 Nov;16(12):1361-5 [15618846] Ann N Y Acad Sci. 2004 Dec;1037:170-4 [15699513] Infect Immun. 2005 Mar;73(3):1523-31 [15731050] Immunol Rev. 2005 Apr;204:27-42 [15790348] J Natl Cancer Inst. 2005 Apr 6;97(7):525-32 [15812078] Leuk Lymphoma. 2005 Jun;46(6):869-72 [16019531] J Clin Oncol. 2005 Aug 1;23(22):5067-73 [15968003] Lancet Oncol. 2006 Jan;7(1):27-38 [16389181] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn262 ER - TY - JOUR T1 - Intakes of red meat, processed meat, and meat mutagens increase lung cancer risk. AN - 66864946; 19141639 AB - Red and processed meat intake may increase lung cancer risk. However, the epidemiologic evidence is inconsistent and few studies have evaluated the role of meat mutagens formed during high cooking temperatures. We investigated the association of red meat, processed meat, and meat mutagen intake with lung cancer risk in Environment And Genetics in Lung cancer Etiology, a population-based case-control study. Primary lung cancer cases (n = 2,101) were recruited from 13 hospitals within the Lombardy region of Italy examining approximately 80% of the cases from the area. Noncancer population controls (n = 2,120), matched to cases on gender, residence, and age, were randomly selected from the same catchment area. Diet was assessed in 1,903 cases and 2,073 controls and used in conjunction with a meat mutagen database to estimate intake of heterocyclic amines (HCA) and benzo(a)pyrene (BaP). Multivariable odds ratios (OR) and 95% confidence intervals (95% CI) for sex-specific tertiles of intake were calculated using unconditional logistic regression. Red and processed meat were positively associated with lung cancer risk (highest-versus-lowest tertile: OR, 1.8; 95% CI, 1.5-2.2; P trend < 0.001 and OR, 1.7; 95% CI, 1.4-2.1; P trend < 0.001, respectively); the risks were strongest among never smokers (OR, 2.4; 95% CI, 1.4-4.0; P trend = 0.001 and OR, 2.5; 95% CI, 1.5-4.2; P trend = 0.001, respectively). HCAs and BaP were significantly associated with increased risk of lung cancer. When separated by histology, significant positive associations for both meat groups were restricted to adenocarcinoma and squamous cell carcinoma but not small cell carcinoma of the lung. In summary, red meat, processed meat, and meat mutagens were independently associated with increased risk of lung cancer. JF - Cancer research AU - Lam, Tram Kim AU - Cross, Amanda J AU - Consonni, Dario AU - Randi, Giorgia AU - Bagnardi, Vincenzo AU - Bertazzi, Pier Alberto AU - Caporaso, Neil E AU - Sinha, Rashmi AU - Subar, Amy F AU - Landi, Maria Teresa AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, NIH, Department of Health and Human Services, [corrected] Bethesda, Maryland 20892-7236, USA. Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 SP - 932 EP - 939 VL - 69 IS - 3 KW - Imidazoles KW - 0 KW - Mutagens KW - Quinoxalines KW - 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline KW - 77500-04-0 KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - 3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine KW - YRA7G7WU6P KW - Index Medicus KW - Animals KW - Chickens KW - Cattle KW - Humans KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Italy -- epidemiology KW - Male KW - Female KW - Meat KW - Lung Neoplasms -- epidemiology KW - Meat Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66864946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Intakes+of+red+meat%2C+processed+meat%2C+and+meat+mutagens+increase+lung+cancer+risk.&rft.au=Lam%2C+Tram+Kim%3BCross%2C+Amanda+J%3BConsonni%2C+Dario%3BRandi%2C+Giorgia%3BBagnardi%2C+Vincenzo%3BBertazzi%2C+Pier+Alberto%3BCaporaso%2C+Neil+E%3BSinha%2C+Rashmi%3BSubar%2C+Amy+F%3BLandi%2C+Maria+Teresa&rft.aulast=Lam&rft.aufirst=Tram&rft.date=2009-02-01&rft.volume=69&rft.issue=3&rft.spage=932&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-3162 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2009-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Causes Control. 2000 May;11(5):419-31 [10877335] BMC Public Health. 2008;8:203 [18538025] Cancer Res. 2000 Jul 15;60(14):3753-6 [10919646] Lung Cancer. 2001 Oct;34(1):37-46 [11557111] Jpn J Cancer Res. 2001 Dec;92(12):1259-69 [11749690] Lung Cancer. 2002 Jan;35(1):43-51 [11750712] Cancer Detect Prev. 2002;26(2):129-38 [12102147] Int J Cancer. 2002 Aug 20;100(6):706-13 [12209611] Drug Metab Rev. 2002 Aug;34(3):667-76 [12214673] Toxicology. 2002 Nov 15;180(2):121-37 [12324189] Lung Cancer. 2002 Oct;38(1):1-7 [12367786] Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):987-92 [12376497] Public Health Nutr. 2002 Dec;5(6B):1243-58 [12639230] Am J Epidemiol. 2003 Jul 1;158(1):14-21; discussion 22-6 [12835281] Environ Mol Mutagen. 2004;44(1):44-55 [15199546] Semin Cancer Biol. 2004 Dec;14(6):473-86 [15489140] Mutat Res. 1975 Dec;31(6):347-64 [768755] Int J Cancer. 1981;27(4):471-4 [7275353] Cancer Res. 1982 Dec;42(12):4875-917 [6814745] Am J Epidemiol. 1991 Apr 1;133(7):683-93 [2018023] Epidemiology. 1992 Jul;3(4):288-99 [1637893] Chem Res Toxicol. 1992 Sep-Oct;5(5):691-7 [1446011] Cancer Causes Control. 1994 Sep;5(5):395-400 [7999960] Carcinogenesis. 1994 Dec;15(12):2757-61 [8001231] Food Chem Toxicol. 1995 Jul;33(7):545-51 [7628789] Int J Epidemiol. 1996 Feb;25(1):32-9 [8666501] Lung Cancer. 1996 Jun;14(2-3):195-205 [8794403] Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):679-82 [8877057] Eur J Cancer Prev. 1996 Sep;5 Suppl 1:109-14 [8972304] Cancer Detect Prev. 1997;21(5):391-405 [9307842] Cancer Causes Control. 1997 Nov;8(6):913-21 [9427434] Nutr Rev. 1998 Apr;56(4 Pt 1):95-105 [9584494] Cancer Causes Control. 1998 Dec;9(6):621-30 [10189048] Carcinogenesis. 1999 Mar;20(3):353-68 [10190547] Mutat Res. 1999 Jul 15;443(1-2):129-38 [10415436] Cancer Lett. 1999 Sep 1;143(2):189-94 [10503902] Int J Epidemiol. 2004 Dec;33(6):1382-6 [15333618] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Chem Res Toxicol. 2005 Sep;18(9):1471-8 [16167840] Epidemiology. 2005 Nov;16(6):772-9 [16222167] Br J Nutr. 2006 Aug;96 Suppl 1:S42-5 [16923250] Am J Clin Nutr. 2006 Nov;84(5):1177-83 [17093172] Carcinogenesis. 2007 Mar;28(3):732-7 [17052995] PLoS Med. 2007 Dec;4(12):e325 [18076279] PLoS Med. 2007 Dec;4(12):e345 [18076281] Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):80-7 [18199713] Cancer Causes Control. 2008 Aug;19(6):649-56 [18264785] Erratum In: Cancer Res. 2009 Apr 1;69(7):3240 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-3162 ER - TY - JOUR T1 - The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells. AN - 66863335; 19176392 AB - Di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone (Dp44mT) is being developed as an iron chelator with selective anticancer activity. We investigated the mechanism whereby Dp44mT kills breast cancer cells, both as a single agent and in combination with doxorubicin. Dp44mT alone induced selective cell killing in the breast cancer cell line MDA-MB-231 when compared with healthy mammary epithelial cells (MCF-12A). It induces G(1) cell cycle arrest and reduces cancer cell clonogenic growth at nanomolar concentrations. Dp44mT, but not the iron chelator desferal, induces DNA double-strand breaks quantified as S139 phosphorylated histone foci (gamma-H2AX) and Comet tails induced in MDA-MB-231 cells. Doxorubicin-induced cytotoxicity and DNA damage were both enhanced significantly in the presence of low concentrations of Dp44mT. The chelator caused selective poisoning of DNA topoisomerase IIalpha (top2alpha) as measured by an in vitro DNA cleavage assay and cellular topoisomerase-DNA complex formation. Heterozygous Nalm-6 top2alpha knockout cells (top2alpha(+/-)) were partially resistant to Dp44mT-induced cytotoxicity compared with isogenic top2alpha(+/+) or top2beta(-/-) cells. Specificity for top2alpha was confirmed using top2alpha and top2beta small interfering RNA knockdown in HeLa cells. The results show that Dp44mT is cytotoxic to breast cancer cells, at least in part, due to selective inhibition of top2alpha. Thus, Dp44mT may serve as a mechanistically unique treatment for cancer due to its dual ability to chelate iron and inhibit top2alpha activity. JF - Cancer research AU - Rao, V Ashutosh AU - Klein, Sarah R AU - Agama, Keli K AU - Toyoda, Eriko AU - Adachi, Noritaka AU - Pommier, Yves AU - Shacter, Emily B AD - US Department of Health and Human Services, Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA. ashutosh.rao@fda.hhs.gov Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 SP - 948 EP - 957 VL - 69 IS - 3 KW - Antigens, Neoplasm KW - 0 KW - DNA-Binding Proteins KW - Iron Chelating Agents KW - Thiosemicarbazones KW - Topoisomerase II Inhibitors KW - di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - DNA topoisomerase II alpha KW - Index Medicus KW - Cell Growth Processes -- drug effects KW - Humans KW - Cell Line, Tumor KW - Cell Cycle -- drug effects KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - DNA Damage KW - DNA-Binding Proteins -- antagonists & inhibitors KW - Thiosemicarbazones -- pharmacology KW - Iron Chelating Agents -- pharmacology KW - Breast Neoplasms -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66863335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=The+iron+chelator+Dp44mT+causes+DNA+damage+and+selective+inhibition+of+topoisomerase+IIalpha+in+breast+cancer+cells.&rft.au=Rao%2C+V+Ashutosh%3BKlein%2C+Sarah+R%3BAgama%2C+Keli+K%3BToyoda%2C+Eriko%3BAdachi%2C+Noritaka%3BPommier%2C+Yves%3BShacter%2C+Emily+B&rft.aulast=Rao&rft.aufirst=V&rft.date=2009-02-01&rft.volume=69&rft.issue=3&rft.spage=948&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1437 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2009-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1437 ER - TY - JOUR T1 - Hallucinations and other psychotic symptoms associated with the use of attention-deficit/hyperactivity disorder drugs in children. AN - 66857245; 19171629 AB - To gain a better understanding of the capacity of psychostimulant medications to induce adverse psychiatric reactions and determine the frequency of such reactions, we analyzed postmarketing surveillance data and clinical trial data for drugs, either approved or under development, for the treatment of attention-deficit/hyperactivity disorder. The US Food and Drug Administration requested manufacturers of drugs approved for attention-deficit/hyperactivity disorder or with active clinical development programs for that indication to search their electronic clinical trial databases for cases of psychosis or mania using prespecified search terms. The manufacturers supplied descriptions of clinical trials, numbers of patients exposed to study drug, and duration of exposure to permit calculations of incidence rates. Independently, cases of psychosis or mania in children and adults for drugs used to treat attention-deficit/hyperactivity disorder from the Food and Drug Administration Adverse Event Reporting System safety database were analyzed. Manufacturers were asked to conduct similar analyses of their postmarketing surveillance databases. We analyzed data from 49 randomized, controlled clinical trials in the pediatric development programs for these products. A total of 11 psychosis/mania adverse events occurred during 743 person-years of double-blind treatment with these drugs, and no comparable adverse events occurred in a total of 420 person-years of placebo exposure in the same trials. The rate per 100 person-years in the pooled active drug group was 1.48. The analysis of spontaneous postmarketing reports yielded >800 reports of adverse events related to psychosis or mania. In approximately 90% of the cases, there was no reported history of a similar psychiatric condition. Hallucinations involving visual and/or tactile sensations of insects, snakes, or worms were common in cases in children. Patients and physicians should be aware that psychosis or mania arising during drug treatment of attention-deficit/hyperactivity disorder may represent adverse drug reactions. JF - Pediatrics AU - Mosholder, Andrew D AU - Gelperin, Kate AU - Hammad, Tarek A AU - Phelan, Kathleen AU - Johann-Liang, Rosemary AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, , MD 20993-0002, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 611 EP - 616 VL - 123 IS - 2 KW - Abridged Index Medicus KW - Index Medicus KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Child KW - Male KW - Female KW - Hallucinations -- chemically induced KW - Psychoses, Substance-Induced -- etiology KW - Attention Deficit Disorder with Hyperactivity -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66857245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Hallucinations+and+other+psychotic+symptoms+associated+with+the+use+of+attention-deficit%2Fhyperactivity+disorder+drugs+in+children.&rft.au=Mosholder%2C+Andrew+D%3BGelperin%2C+Kate%3BHammad%2C+Tarek+A%3BPhelan%2C+Kathleen%3BJohann-Liang%2C+Rosemary&rft.aulast=Mosholder&rft.aufirst=Andrew&rft.date=2009-02-01&rft.volume=123&rft.issue=2&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2008-0185 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-05 N1 - Date created - 2009-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.2008-0185 ER - TY - JOUR T1 - Benchmark dose estimation incorporating multiple data sources. AN - 66857234; 19000080 AB - With the increased availability of toxicological hazard information arising from multiple experimental sources, risk assessors are often confronted with the challenge of synthesizing all available scientific information into an analysis. This analysis is further complicated because significant between-source heterogeneity/lab-to-lab variability is often evident. We estimate benchmark doses using hierarchical models to account for the observed heterogeneity. These models are used to construct source-specific and population-average estimates of the benchmark dose (BMD). This is illustrated with an analysis of the U.S. EPA Region IX's reference toxicity database on the effects of sodium chloride on reproduction in Ceriodaphnia dubia. Results show that such models may effectively account for the lab-source heterogeneity while producing BMD estimates that more truly reflect the variability of the system under study. Failing to account for such heterogeneity may result in estimates having confidence intervals that are overly narrow. JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Wheeler, Matthew W AU - Bailer, A John AD - National Institute for Occupational Safety and Health, Risk Evaluation Branch, Cincinnati, OH, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 249 EP - 256 VL - 29 IS - 2 KW - Water Pollutants, Chemical KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Index Medicus KW - Software KW - Animals KW - Regression Analysis KW - Algorithms KW - Models, Statistical KW - Benchmarking KW - Daphnia KW - Poisson Distribution KW - Multivariate Analysis KW - Risk Assessment KW - Risk KW - Sodium Chloride -- toxicity KW - Environmental Exposure KW - Data Collection KW - Water Pollutants, Chemical -- analysis KW - Water Pollutants, Chemical -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66857234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.atitle=Benchmark+dose+estimation+incorporating+multiple+data+sources.&rft.au=Wheeler%2C+Matthew+W%3BBailer%2C+A+John&rft.aulast=Wheeler&rft.aufirst=Matthew&rft.date=2009-02-01&rft.volume=29&rft.issue=2&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Risk+analysis+%3A+an+official+publication+of+the+Society+for+Risk+Analysis&rft.issn=1539-6924&rft_id=info:doi/10.1111%2Fj.1539-6924.2008.01144.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-24 N1 - Date created - 2009-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1539-6924.2008.01144.x ER - TY - JOUR T1 - Medical response to a radiologic/nuclear event: integrated plan from the Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services. AN - 66849472; 18387707 AB - The end of the Cold War led to a reduced concern for a major nuclear event. However, the current threats from terrorism make a radiologic (dispersal or use of radioactive material) or nuclear (improvised nuclear device) event a possibility. The specter and enormousness of the catastrophe resulting from a state-sponsored nuclear attack and a sense of nihilism about the effectiveness of a response were such that there had been limited civilian medical response planning. Although the consequences of a radiologic dispersal device are substantial, and the detonation of a modest-sized (10 kiloton) improvised nuclear device is catastrophic, it is both possible and imperative that a medical response be planned. To meet this need, the Office of the Assistant Secretary for Preparedness and Response in the Department of Health and Human Services, in collaboration within government and with nongovernment partners, has developed a scientifically based comprehensive planning framework and Web-based "just-in-time" medical response information called Radiation Event Medical Management (available at http://www.remm.nlm.gov). The response plan includes (1) underpinnings from basic radiation biology, (2) tailored medical responses, (3) delivery of medical countermeasures for postevent mitigation and treatment, (4) referral to expert centers for acute treatment, and (5) long-term follow-up. Although continuing to evolve and increase in scope and capacity, current response planning is sufficiently mature that planners and responders should be aware of the basic premises, tools, and resources available. An effective response will require coordination, communication, and cooperation at an unprecedented level. The logic behind and components of this response are presented to allow for active collaboration among emergency planners and responders and federal, state, local, and tribal governments. JF - Annals of emergency medicine AU - Coleman, C Norman AU - Hrdina, Chad AU - Bader, Judith L AU - Norwood, Ann AU - Hayhurst, Robert AU - Forsha, Joseph AU - Yeskey, Kevin AU - Knebel, Ann AD - Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC 20201, USA. ccoleman@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 213 EP - 222 VL - 53 IS - 2 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Acute Radiation Syndrome KW - Transportation KW - Triage KW - Humans KW - Government Agencies KW - Mass Casualty Incidents KW - Algorithms KW - United States Dept. of Health and Human Services KW - Disaster Planning -- organization & administration KW - Terrorism KW - Civil Defense -- organization & administration KW - Radioactive Hazard Release KW - Nuclear Warfare KW - Disasters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66849472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+emergency+medicine&rft.atitle=Medical+response+to+a+radiologic%2Fnuclear+event%3A+integrated+plan+from+the+Office+of+the+Assistant+Secretary+for+Preparedness+and+Response%2C+Department+of+Health+and+Human+Services.&rft.au=Coleman%2C+C+Norman%3BHrdina%2C+Chad%3BBader%2C+Judith+L%3BNorwood%2C+Ann%3BHayhurst%2C+Robert%3BForsha%2C+Joseph%3BYeskey%2C+Kevin%3BKnebel%2C+Ann&rft.aulast=Coleman&rft.aufirst=C&rft.date=2009-02-01&rft.volume=53&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Annals+of+emergency+medicine&rft.issn=1097-6760&rft_id=info:doi/10.1016%2Fj.annemergmed.2007.12.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Emerg Med. 2009 Feb;53(2):223-5 [18387705] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.annemergmed.2007.12.021 ER - TY - JOUR T1 - Tax-Exempt Hospitals and Community Benefits: A Review of State Reporting Requirements AN - 61723890; 200913904 AB - In June 2007 the Internal Revenue Service proposed a major overhaul of its reporting requirements for tax-exempt hospitals and released draft Form 990 (the IRS form filed by tax-exempt organizations each year). In December 2007 the IRS promulgated the final Form 990 after incorporating some of the recommendations made in the almost seven hundred public comments on the discussion draft. One recommendation adopted in the final Form 990 is the postponement until tax year 2009 (returns filed in 2010) of the requirement for hospitals to submit detailed information on the percentage of total expenses attributable to charity care, unreimbursed Medicaid costs, and community-health improvement programs (the discussion draft required this information for tax year 2007). Although the IRS will not require tax-exempt hospitals to provide detailed information about community benefits until the 2009 tax year, sixteen states have laws requiring tax-exempt hospitals to enumerate the benefits that they provide to the community. Information about the impact of these laws on the provision of community benefits (e.g., charity and uncompensated care) is examined in this study whose primary purpose is to highlight information policy makers may glean from states that have adopted community-benefit reporting laws. Adapted from the source document. JF - Journal of Health Politics, Policy and Law AU - Hellinger, Fred Joseph AD - Agency for Healthcare Research and Quality Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 37 EP - 61 PB - Duke University Press, Durham NC VL - 34 IS - 1 SN - 0361-6878, 0361-6878 KW - Taxation KW - Philanthropy KW - Law KW - Benefits KW - Health Care Services KW - Hospitals KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61723890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Politics%2C+Policy+and+Law&rft.atitle=Tax-Exempt+Hospitals+and+Community+Benefits%3A+A+Review+of+State+Reporting+Requirements&rft.au=Hellinger%2C+Fred+Joseph&rft.aulast=Hellinger&rft.aufirst=Fred&rft.date=2009-02-01&rft.volume=34&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Politics%2C+Policy+and+Law&rft.issn=03616878&rft_id=info:doi/10.1215%2F03616878-2008-035 LA - English DB - Sociological Abstracts N1 - Date revised - 2009-04-15 N1 - Number of references - 45 N1 - Last updated - 2016-09-28 N1 - CODEN - JHPLDN N1 - SubjectsTermNotLitGenreText - Hospitals; Taxation; Philanthropy; Health Care Services; Benefits; Law DO - http://dx.doi.org/10.1215/03616878-2008-035 ER - TY - JOUR T1 - Marital Dissolution Among Interracial Couples AN - 61694172; 200913768 AB - Increases in interracial marriage have been interpreted as reflecting reduced social distance among racial and ethnic groups, but little is known about the stability of interracial marriages. Using six panels of Survey of Income and Program Participation (N = 23,139 married couples), we found that interracial marriages are less stable than endogamous marriages, but these findings did not hold up consistently. After controlling for couple characteristics, the risk of divorce or separation among interracial couples was similar to the more-divorce-prone origin group. Although marital dissolution was found to be strongly associated with race or ethnicity, the results failed to provide evidence that interracial marriage per se is associated with an elevated risk of marital dissolution. Adapted from the source document. JF - Journal of Marriage and Family AU - Zhang, Yuanting AU - Van, Jennifer AD - Food and Drug Administration zhangyuant@gmail.com Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 95 EP - 107 PB - Blackwell Publishers, Malden MA VL - 71 IS - 1 SN - 0022-2445, 0022-2445 KW - Risk KW - Divorce KW - Ethnicity KW - Race KW - Marital Satisfaction KW - Intermarriage KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61694172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Marriage+and+Family&rft.atitle=Marital+Dissolution+Among+Interracial+Couples&rft.au=Zhang%2C+Yuanting%3BVan%2C+Jennifer&rft.aulast=Zhang&rft.aufirst=Yuanting&rft.date=2009-02-01&rft.volume=71&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+Marriage+and+Family&rft.issn=00222445&rft_id=info:doi/10.1111%2Fj.1741-3737.2008.00582.x LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 41 N1 - Last updated - 2016-09-28 N1 - CODEN - JMFAA6 N1 - SubjectsTermNotLitGenreText - Marital Satisfaction; Divorce; Intermarriage; Race; Ethnicity; Risk DO - http://dx.doi.org/10.1111/j.1741-3737.2008.00582.x ER - TY - BOOK T1 - Occupational Health of Hired Farmworkers in the United States National Agricultural Workers Survey Occupational Health Supplement, 1999 AN - 58827008; 2008-442377 AB - Hired farmworkers form a core component of the agricultural workforce in the United States, numbering an estimated 1.8 million workers. Very little national health data exists on this population because of difficulties in identifying and enumerating them. In 1998, to define the magnitude and scope of hired farmworker occupational health problems, the National Institute for Occupational Safety and Health (NIOSH) collaborated with the Department of Labor to collect occupational safety and health information about a nationally representative sample of hired farmworkers. The collaboration allowed NIOSH to include questions on occupational health in an existing Department of Labor survey, the National Agricultural Workers Survey. The purpose of the original survey continues to be the collection of demographic and employment data on hired crop farmworkers. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Feb 2009, 137 pp. AU - National Institute for Occupational Safety and Health Y1 - 2009/02// PY - 2009 DA - February 2009 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Agriculture and agricultural policy - Crop management and agricultural production KW - Labor conditions and policy - Work and labor KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Health conditions and policy - Health and health policy KW - United States KW - Agriculture KW - Demographics KW - Working conditions KW - Labor KW - Public health KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58827008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=Biomaterials&rft.atitle=Inhibition+of+Taq+polymerase+as+a+method+for+screening+heparin+for+oversulfated+contaminants&rft.au=Tami%2C+C%3BPuig%2C+M%3BReepmeyer%2C+J+C%3BYe%2C+H%3BD%27Avignon%2C+DA%3BBuhse%2C+L%3BVerthelyi%2C+D&rft.aulast=Tami&rft.aufirst=C&rft.date=2008-12-01&rft.volume=29&rft.issue=36&rft.spage=4808&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2008.08.024 L2 - http://www.cdc.gov/niosh/docs/2009-119/pdfs/Book%202%20508v2.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-02-03 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2009 N1 - SuppNotes - NIOSH Publication No. 2009-119 N1 - Last updated - 2016-09-28 ER - TY - RPRT T1 - Table of contents AN - 236500273 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236500273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-02-01&rft.volume=&rft.issue=542&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Feb 2009 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF CUMENE (CAS NO. 98-82-8) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) AN - 236500202; 19340095 AB - Cumene occurs naturally in petroleum and is used as a solvent, in gasoline and diesel fuels, and as the principal chemical in the production of phenol and acetone. We studied cumene to determine if it caused cancer in rats or mice. We exposed groups of 50 male and female rats and mice to air containing cumene 6 hours per day for 2 years. Rats and male mice were exposed to concentrations of 250, 500, or 1,000 parts per million (ppm) of cumene in air, and female mice were exposed to concentrations of 125, 250, or 500 ppm. Similar groups of 50 animals were exposed to clean air in the same inhalation chambers 6 hours per day as the untreated control groups. Tissues from more than 40 sites were examined for every animal. All groups of animals exposed to cumene exhibited hyperplasia of the epithelial tissues of the nose, and exposed male and female mice experienced metaplasia and hyperplasia of the lung. Male mice also had nonneoplastic lesions in the forestomach and liver. Adenomas of the respiratory epithelium of the nose were observed in male and female rats, and male rats had increased incidences of renal tubule adenoma or carcinoma (combined) and interstitial cell adenoma of the testis. Adenomas and carcinomas of the lung were markedly increased in male and female mice exposed to cumene. The rate of liver neoplasms was also increased in exposed female mice, and a few hemangiosarcomas of the spleen and follicular cell adenomas of the thyroid gland were seen in male mice exposed to the highest concentration of cumene. We conclude that the increased occurrences of adenomas of the epithelium of the nose in male and female rats, of renal tubule adenoma or carcinoma (combined), of adenomas and carcinomas of the lung in male and female mice, and of liver neoplasms in female mice were caused by exposure to cumene. The occurrence of interstitial cell adenoma of the testis in male rats and hemangiosarcomas of the spleen and follicular cell adenomas of the thyroid gland in male mice may also have been associated with exposure to cumene. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 1 EP - 200 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Benzene Derivatives KW - cumene KW - Toxicology KW - Rodents KW - Carcinogens KW - Solvents KW - Petroleum products KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Inhalation Exposure KW - Body Weight -- drug effects KW - Benzene Derivatives -- metabolism KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Benzene Derivatives -- toxicity KW - Neoplasms, Experimental -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236500202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+CUMENE+%28CAS+NO.+98-82-8%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-02-01&rft.volume=&rft.issue=542&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Feb 2009 N1 - Document feature - References; Tables; Diagrams; Graphs; Photographs N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 236500141 AB - Established in 1978, the NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236500141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-02-01&rft.volume=&rft.issue=549&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Feb 2009 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 236448309 AB - Established in 1978, the NTP is ch arged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Environmental health KW - Public health KW - Laboratory animals KW - Human exposure KW - Health services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236448309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-02-01&rft.volume=&rft.issue=542&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Feb 2009 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF BROMOCHLOROACETIC ACID (CAS NO. 5589-96-8) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES) AN - 236448243; 19340096 AB - Bromochloroacetic acid occurs as a by-product of water disinfection. We studied the effects of bromochloroacetic acid in drinking water on male and female rats and mice to identify potential toxic or cancer-related hazards. We gave drinking water containing 250, 500, or 1,000 mg of bromochloroacetic acid per liter of water to groups of 50 male and female rats and mice for 2 years. Control animals received the same tap water with no chemical added. At the end of the study tissues from more than 40 sites were examined for every animal. Survival was similar for rats and female mice receiving bromochloroacetic acid and the controls; survival of 1,000 mg/L male mice was less. Male rats receiving bromochloroacetic acid had increased rates of malignant mesotheliomas. Adenomas of the large intestine were seen in both male and female rats receiving the highest concentration of bromochloroacetic acid. Exposed female rats also had increased incidences of multiple fibroadenomas of the mammary gland. Slightly increased incidences of liver hepatocellular adenomas in male and female rats and pancreatic islet adenomas in male rats were also observed in exposed animals. Male and female mice exposed to bromochloroacetic acid had increased rates of a variety of liver cancers. We conclude that bromochloroacetic acid in the drinking water caused mesothelioma in male rats, multiple fibroadenomas of the mammary gland in female rats, and adenomas of the large intestine in both male and female rats. Adenomas of the liver in male and female rats and of the pancreatic islets in male rats may also have been related to bromochloroacetic acid exposure. We conclude that bromochloroacetic acid caused liver cancer in male and female mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 1 EP - 269 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Acetates KW - bromochloroacetic acid KW - Drinking water KW - Carcinogens KW - Rodents KW - Toxicology KW - Acids KW - Rats KW - Drinking KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Acetates -- metabolism KW - Mice KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Acetates -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236448243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+BROMOCHLOROACETIC+ACID+%28CAS+NO.+5589-96-8%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28DRINKING+WATER+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-02-01&rft.volume=&rft.issue=549&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Feb 2009 N1 - Document feature - Tables; Equations; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 236441277 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/236441277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-02-01&rft.volume=&rft.issue=549&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Feb 2009 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Identification and Characterization of Class 1 Integron Resistance Gene Cassettes among Salmonella Strains Isolated from Imported Seafood AN - 21498556; 12510613 AB - A total of 210 Salmonella isolates, representing 64 different serovars, were isolated from imported seafood samples, and 55/210 isolates were found to be resistant to at least one antibiotic. Class 1 integrons from three multidrug-resistant Salmonella enterica strains (Salmonella enterica serovars Newport [strain 62], Typhimurium var. Copenhagen [strain 629], and Lansing [strain 803], originating from Hong Kong, the Philippines, and Taiwan, respectively) were characterized. Southern hybridization of plasmids isolated from these strains, using a class 1 integron probe, showed that trimethoprim-sulfamethoxazole and streptomycin resistance genes were located on a megaplasmid in strain 629. Our study indicates that imported seafood could be a reservoir for Salmonella isolates resistant to multiple antibiotics. JF - Applied and Environmental Microbiology AU - Khan, Ashraf A AU - Ponce, Elizabeth AU - Nawaz AU - Cheng, Chorng-Ming AU - Khan, Junaid A AU - West, Christine S AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, Ashraf.khan@fda.hhs.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 1192 EP - 1196 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 75 IS - 4 SN - 0099-2240, 0099-2240 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Antibiotics KW - Salmonella enterica KW - Seafood KW - J 02310:Genetics & Taxonomy KW - A 01330:Food Microbiology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21498556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Identification+and+Characterization+of+Class+1+Integron+Resistance+Gene+Cassettes+among+Salmonella+Strains+Isolated+from+Imported+Seafood&rft.au=Khan%2C+Ashraf+A%3BPonce%2C+Elizabeth%3BNawaz%3BCheng%2C+Chorng-Ming%3BKhan%2C+Junaid+A%3BWest%2C+Christine+S&rft.aulast=Khan&rft.aufirst=Ashraf&rft.date=2009-02-01&rft.volume=75&rft.issue=4&rft.spage=1192&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02054-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Seafood; Salmonella enterica DO - http://dx.doi.org/10.1128/AEM.02054-08 ER - TY - JOUR T1 - Comparison of gene expression profiles in mice liver following intravenous injection of 4 and 100nm-sized PEG-coated gold nanoparticles AN - 21212717; 11201108 AB - Gold nanoparticles (AuNPs) have been widely used in various biomedical applications for photothermal therapy, imaging and drug delivery. Although AuNPs have been recognized as a biologically safe material, very little is known about their molecular and cellular effects. To evaluate the gene expression profile and mechanism of the molecular level of polyethylene glycol (PEG)-coated AuNPs and the effect of particle size, we applied an expression profiling approach. PEG-coated AuNPs of different particle sizes, 4 and 100nm, were intravenously administered to BALB/c mice (4.26mg/kg, body weight). Thirty minutes after injection of AuNPs, the mice were sacrificed and liver tissues were removed. Then, pathological examination and microarray analysis were performed on the liver tissues. Histology of the liver tissues did not indicate any pathological changes in all treatment groups. Only 0.38% (170 genes) and 0.50% (224 genes) of the total genes (45,000 genes) were significantly induced by the treatment of 4 or 100nm AuNPs, respectively. In addition, the 4 and 100nm AuNPs treatment groups shared 67.1% and 50.9% of the significantly changed genes, respectively. Commonly expressed genes by a single intravenous injection of 4 or 100nm AuNPs were categorized as apoptosis, cell cycle, inflammation, and metabolic process. In the specifically expressed genes of 4 or 100nm AuNPs, although the genes were different each other, 4 and 100nm AuNPs showed similar gene categories such as cell cycle, response to stress, signal transduction, and metabolic process. Therefore, we can conclude that 4 and 100nm AuNPs showed similar biological effects on liver tissues of mice. JF - Toxicology Letters AU - Cho, W S AU - Kim, S AU - Han, B S AU - Son, W C AU - Jeong, J AD - National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, 231 Jinhoungno Eunpyung-ku, Seoul 122-704, Republic of Korea, jjy_kfda@kfda.go.kr PY - 2009 SP - 96 EP - 102 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 191 IS - 1 SN - 0378-4274, 0378-4274 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Toxicology Abstracts KW - Particle size KW - Drug delivery KW - Intravenous administration KW - Apoptosis KW - Cell cycle KW - Stress KW - imaging KW - Inflammation KW - Gene expression KW - Body weight KW - Liver KW - Gold KW - Polyethylene glycol KW - nanoparticles KW - Signal transduction KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21212717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Comparison+of+gene+expression+profiles+in+mice+liver+following+intravenous+injection+of+4+and+100nm-sized+PEG-coated+gold+nanoparticles&rft.au=Cho%2C+W+S%3BKim%2C+S%3BHan%2C+B+S%3BSon%2C+W+C%3BJeong%2C+J&rft.aulast=Cho&rft.aufirst=W&rft.date=2009-02-01&rft.volume=191&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2009.08.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Particle size; Drug delivery; Intravenous administration; Apoptosis; Cell cycle; Stress; imaging; Inflammation; Gene expression; Body weight; Liver; Gold; nanoparticles; Polyethylene glycol; Signal transduction DO - http://dx.doi.org/10.1016/j.toxlet.2009.08.010 ER - TY - JOUR T1 - Evaluating Co-primary Endpoints Collectively in Clinical Trials AN - 21090475; 11133090 AB - Often a treatment is assessed by co-primary endpoints so that a comprehensive picture of the treatment effect can be obtained. Co-primary endpoints can be different medical assessments angled at different aspects of a disease, therefore, are used collectively to strengthen evidence for the treatment effect. It is common sense that if a treatment is ineffective, the chance to show that the treatment is effective in all co-primary endpoints should be small. Therefore, it may not be necessary to require all the co-primary endpoints to be statistically significant at the 1-sided 0.025 level to control the error rate of wrongly approving an ineffective treatment. Rather it is reasonable to allow certain variation for the p -values within a range close to 0.025. In this paper, statistical methods are developed to derive decision rules to evaluate co-primary endpoints collectively. The decision rules control the error rate of wrongly accepting an ineffective treatment at the level of 0.025 for a study and the error rate at a slightly higher level for a treatment that works for all the co-primary endpoints except perhaps one. The decision rules also control the error rates for individual endpoints. Potential applications in clinical trials are presented. JF - Biometrical Journal AU - Li, Qian H AD - Center for Drug Evaluation and Research, US FDA, 10903 New Hampshire Ave., Silve Spring, MD 20993, USA, qian.li@fda.hhs.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 137 EP - 145 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 1 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Statistical analysis KW - Clinical trials KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21090475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Evaluating+Co-primary+Endpoints+Collectively+in+Clinical+Trials&rft.au=Li%2C+Qian+H&rft.aulast=Li&rft.aufirst=Qian&rft.date=2009-02-01&rft.volume=51&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200710497 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Clinical trials; Statistical analysis; Statistics DO - http://dx.doi.org/10.1002/bimj.200710497 ER - TY - JOUR T1 - A Regulatory Science Perspective on Warfarin Therapy: A Pharmacogenetic Opportunity AN - 20657808; 9400977 AB - Warfarin is a challenging drug to accurately dose, both initially and for maintenance, because of its narrow therapeutic range, wide interpatient variability, and long list of factors that can influence dosing. Two million people in the United States are initiated on warfarin therapy annually, and this number is steadily increasing because of the increase in number of eligible patients. Recently, warfarin was reported to be the fourth leading cause of adverse events. The U.S. Food and Drug Administration recognizes that the adverse event rate of warfarin can be improved through better initial dosing, because many of the serious adverse events of warfarin occur soon after starting treatment. A substantial number of studies demonstrate that common variants of two genes, VKORC1 and CYP2C9, along with other nongenetic factors, correlate significantly with warfarin dosing. The genotypes of VKORC1 and CYP2C9 alone account for nearly 3 times more of the variability (30%) in warfarin dosing than do age, weight, gender, and other clinical factors combined (12%). Therefore, the purpose of this report is to review the current recommendations for warfarin therapy that involve genetic testing. JF - Journal of Clinical Pharmacology AU - Kim, Myong-Jin AU - Huang, Shiew-Mei AU - Meyer, Urs A AU - Rahman, Atiqur AU - Lesko, Lawrence J AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, shiewmei.huang@fda.hhs.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 138 EP - 146 PB - Sage Publications Ltd., 6 Bonhill St. VL - 49 IS - 2 SN - 0091-2700, 0091-2700 KW - warfarin KW - Genetics Abstracts; Health & Safety Science Abstracts KW - Warfarin KW - pharmacogenetics KW - CYP2C9 KW - VKORC1 KW - Age KW - Genotypes KW - Maintenance KW - Pharmacogenetics KW - USA KW - genetic screening KW - Reviews KW - Gender KW - Genetic screening KW - Drugs KW - Side effects KW - G 07730:Development & Cell Cycle KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20657808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=A+Regulatory+Science+Perspective+on+Warfarin+Therapy%3A+A+Pharmacogenetic+Opportunity&rft.au=Kim%2C+Myong-Jin%3BHuang%2C+Shiew-Mei%3BMeyer%2C+Urs+A%3BRahman%2C+Atiqur%3BLesko%2C+Lawrence+J&rft.aulast=Kim&rft.aufirst=Myong-Jin&rft.date=2009-02-01&rft.volume=49&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270008328098 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Genetic screening; Genotypes; Warfarin; Pharmacogenetics; genetic screening; Reviews; Gender; Drugs; Maintenance; Side effects; USA DO - http://dx.doi.org/10.1177/0091270008328098 ER - TY - JOUR T1 - Bobs first decade: in at the beginning AN - 20631370; 9372323 AB - Arriving at the Bureau of Radiological Health in 1972, Bob Wagner was thrust into the Bureaus quandary over how to quantify the imaging benefit associated with the radiation dose cost of medical imaging procedures. In short order he had set up the framework for FDA imaging research for the next 36 years. Bob played a key role in these early years in assisting in the founding of the SPIE Medical Imaging series of meetings, in measuring and organizing round robin comparisons of imaging measurements of the fundamental physical quantities required for performance evaluation, and in developing the framework for how these measurements could be combined to provide meaningful assessment figures of merit. He worked assiduously to counter both those who claimed that radiology was an art not a science and those who made extravagant claims for the dose reduction/image quality benefits of their particular variety of image capture/image processing system. In the process he became one of the founding fathers and key participants in the medical image performance assessment community as represented today at SPIE Medical Imaging 2009. JF - Proceedings of SPIE - The International Society for Optical Engineering AU - Brown, David G AD - Ctr. for Devices and Radiological Health, FDA (USA) Y1 - 2009/02// PY - 2009 DA - Feb 2009 PB - SPIE, P.O. BOX 10 Bellingham WA 98227-0010 USA, [mailto:spie@spie.org], [URL:http://spie.org] VL - 7263 SN - 0277-786X, 0277-786X KW - Environment Abstracts KW - Article no. 72630D KW - Perception KW - FDA KW - Radiology KW - performance assessment KW - technology assessment KW - ENA 08:International UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20631370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Proceedings+of+SPIE+-+The+International+Society+for+Optical+Engineering&rft.atitle=Bobs+first+decade%3A+in+at+the+beginning&rft.au=Brown%2C+David+G&rft.aulast=Brown&rft.aufirst=David&rft.date=2009-02-01&rft.volume=7263&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+SPIE+-+The+International+Society+for+Optical+Engineering&rft.issn=0277786X&rft_id=info:doi/10.1117%2F12.817797 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - SuppNotes - Session: Medical Imaging and Radiological Health: Contributions of Dr. Robert F. Wagner N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Perception; FDA; performance assessment; Radiology; technology assessment DO - http://dx.doi.org/10.1117/12.817797 ER - TY - JOUR T1 - Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus? AN - 20598504; 9302135 AB - Nanotechnology is an emerging science involving manipulation of materials at the nanometer scale. There are several exciting prospects for the application of engineered nanomaterials in medicine. However, concerns over adverse and unanticipated effects on human health have also been raised. In fact, the same properties that make engineered nanomaterials attractive from a technological and biomedical perspective could also make these novel materials harmful to human health and the environment. Carbon nanotubes are cylinders of one or several coaxial graphite layer(s) with a diameter in the order of nanometers, and serve as an instructive example of the Janus-like properties of nanomaterials. Numerous in vitro and in vivo studies have shown that carbon nanotubes and/or associated contaminants or catalytic materials that arise during the production process may induce oxidative stress and prominent pulmonary inflammation. Recent studies also suggest some similarities between the pathogenic properties of multi-walled carbon nanotubes and those of asbestos fibers. On the other hand, carbon nanotubes can be readily functionalized and several studies on the use of carbon nanotubes as versatile excipients for drug delivery and imaging of disease processes have been reported, suggesting that carbon nanotubes may have a place in the armamentarium for treatment and monitoring of cancer, infection, and other disease conditions. Nanomedicine is an emerging field that holds great promise; however, close attention to safety issues is required to ensure that the opportunities that carbon nanotubes and other engineered nanoparticles offer can be translated into feasible and safe constructs for the treatment of human disease. JF - Pharmacology & Therapeutics AU - Shvedova, A A AU - Kisin, E R AU - Porter, D AU - Schulte, P AU - Kagan, V E AU - Fadeel, B AU - Castranova, V AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, United States, ats1@cdc.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 192 EP - 204 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 121 IS - 2 SN - 0163-7258, 0163-7258 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Graphite KW - Infection KW - Carbon KW - Oxidative stress KW - Asbestos KW - Toxicity KW - imaging KW - Cancer KW - Inflammation KW - Fibers KW - Lung KW - nanotubes KW - Contaminants KW - nanoparticles KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20598504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+Therapeutics&rft.atitle=Mechanisms+of+pulmonary+toxicity+and+medical+applications+of+carbon+nanotubes%3A+Two+faces+of+Janus%3F&rft.au=Shvedova%2C+A+A%3BKisin%2C+E+R%3BPorter%2C+D%3BSchulte%2C+P%3BKagan%2C+V+E%3BFadeel%2C+B%3BCastranova%2C+V&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2009-02-01&rft.volume=121&rft.issue=2&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+Therapeutics&rft.issn=01637258&rft_id=info:doi/10.1016%2Fj.pharmthera.2008.10.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Carbon; nanotubes; nanotechnology; Lung; imaging; nanoparticles; Graphite; Toxicity; Contaminants; Inflammation; Oxidative stress; Asbestos; Drug delivery; Cancer; Infection; Fibers DO - http://dx.doi.org/10.1016/j.pharmthera.2008.10.009 ER - TY - JOUR T1 - Body mass index and risk of ovarian cancer AN - 20447851; 9131600 AB - BACKGROUND: Convincing epidemiologic evidence links excess body mass to increased risks of endometrial and postmenopausal breast cancers, but the relation between body mass index (BMI) and ovarian cancer risk remains inconclusive. Potential similarities regarding a hormonal mechanism in the etiology of female cancers highlight the importance of investigating associations according to menopausal hormone therapy (MHT) use. However, to the authors' knowledge, data addressing whether the relation between BMI and ovarian cancer differs by MHT use are very sparse. METHODS: The authors prospectively investigated the association between BMI and ovarian cancer among 94,525 US women who were followed between 1996 through 1997 to December 31, 2003. During 7 years of follow-up, 303 epithelial ovarian cancer cases were documented. RESULTS: Compared with normal weight women (BMI of 18.5-24.9 kg/m2), the multivariate relative risk (MVRR) of ovarian cancer for obese women (BMI of 30 kg/m2) in the cohort as a whole was 1.26 (95% confidence interval [95% CI], 0.94-1.68). Among women who never used MHT, the MVRR for obese versus normal weight women was 1.83 (95% CI, 1.18-2.84). In contrast, no relation between BMI and ovarian cancer was apparent among women who ever used MHT (MVRR = 0.96; 95% CI, 0.65-1.43; P interaction = 0.02). Exploratory analyses also suggested a positive association between BMI and ovarian cancer among women without a family history of ovarian cancer (MVRR comparing obese vs normal weight women = 1.36; 95% CI, 1.00-1.86), but no relation with BMI was apparent among women with a positive family history of ovarian cancer (MVRR = 0.74; 95% CI, 0.34-1.62 [P interaction = .02]). CONCLUSIONS: Based on the results of the current study, the authors suspect that obesity is associated with enhanced ovarian cancer risk through a hormonal mechanism. Cancer 2009. Published 2009 by the American Cancer Society. JF - Cancer AU - Leitzmann, Michael F AU - Koebnick, Corinna AU - Danforth, Kim N AU - Brinton, Louise A AU - Moore, Steven C AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Lacey Jr, James V AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, michael.leitzmann@klinik.uni-regensburg.de Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 812 EP - 822 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 115 IS - 4 SN - 0008-543X, 0008-543X KW - Physical Education Index; Risk Abstracts KW - Obesity KW - Etiology KW - post-menopause KW - ovarian carcinoma KW - Body mass KW - Women KW - obesity KW - Interaction analysis KW - Breasts KW - Hormones KW - Cancer KW - Knowledge KW - Genetics KW - Weight KW - body mass KW - Breast cancer KW - Family KW - PE 090:Sports Medicine & Exercise Sport Science KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20447851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Body+mass+index+and+risk+of+ovarian+cancer&rft.au=Leitzmann%2C+Michael+F%3BKoebnick%2C+Corinna%3BDanforth%2C+Kim+N%3BBrinton%2C+Louise+A%3BMoore%2C+Steven+C%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BLacey+Jr%2C+James+V&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2009-02-01&rft.volume=115&rft.issue=4&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24086 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Weight; Body mass; Women; Interaction analysis; Family; Breasts; Knowledge; Cancer; Genetics; Etiology; post-menopause; body mass; ovarian carcinoma; obesity; Breast cancer; Hormones DO - http://dx.doi.org/10.1002/cncr.24086 ER - TY - JOUR T1 - Bipolar diffusion charging characteristics of single-wall carbon nanotube aerosol particles AN - 20395334; 9068675 AB - Bipolar diffusion charging characteristics of airborne single-wall carbon nanotube (SWCNT) agglomerates were investigated in the mobility diameter range of 100-1000 nm. Neutral fractions of three types of SWCNT aerosols following bipolar charge equilibrium in a radioactive source were experimentally measured to infer their electrical charging characteristics. Significant deviation from Boltzmann and Fuchs stationary charge equilibrium was observed, with neutral fractions of SWCNT particles lower by 30-53% compared to that of spherical particles of the same mobility. Particles with mobility diameter larger than 400 nm showed high electrical charging efficiencies compared to that of mobility-equivalent spherical particles. Higher charging efficiencies of SWCNT particles were attributed to their higher electrical capacitance resulting from complex nonspherical morphologies. Numerical calculations using idealized fiber geometries confirmed the qualitative trend in the experimental data. The electrical capacitance of nanotubes particles deduced from experimentally measured neutral fractions were also found to be higher by a factor ranging from 1.6 to 4.6 compared to that of mobility-equivalent spherical particles, indicating high charge carrying capacity. The charging-equivalent diameters of nanotube particles were computed and were found to be higher than their mobility diameter by a factor of 2.85-4.34. JF - Journal of Aerosol Science AU - Kulkarni, Pramod AU - Deye, Gregory J AU - Baron, Paul A AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS: R-3, Cincinnati, OH 45225, USA, PSKulkarni@cdc.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 164 EP - 179 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 40 IS - 2 SN - 0021-8502, 0021-8502 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Single-wall carbon nanotubes KW - Diffusion charging KW - Fibers KW - Aerosols KW - Mobility KW - Aerosol particles KW - Morphology KW - Diffusion KW - Particulates KW - carrying capacity KW - nanotechnology KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20395334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aerosol+Science&rft.atitle=Bipolar+diffusion+charging+characteristics+of+single-wall+carbon+nanotube+aerosol+particles&rft.au=Kulkarni%2C+Pramod%3BDeye%2C+Gregory+J%3BBaron%2C+Paul+A&rft.aulast=Kulkarni&rft.aufirst=Pramod&rft.date=2009-02-01&rft.volume=40&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aerosol+Science&rft.issn=00218502&rft_id=info:doi/10.1016%2Fj.jaerosci.2008.09.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Aerosol particles; Fibers; Aerosols; Mobility; Morphology; Diffusion; Particulates; carrying capacity; nanotechnology DO - http://dx.doi.org/10.1016/j.jaerosci.2008.09.008 ER - TY - JOUR T1 - A new method for improving functional-to-structural MRI alignment using local Pearson correlation AN - 20394441; 9066141 AB - Accurate registration of Functional Magnetic Resonance Imaging (FMRI) T2-weighted volumes to same-subject high-resolution T1-weighted structural volumes is important for Blood Oxygenation Level Dependent (BOLD) FMRI and crucial for applications such as cortical surface-based analyses and pre-surgical planning. Such registration is generally implemented by minimizing a cost functional, which measures the mismatch between two image volumes over the group of proper affine transformations. Widely used cost functionals, such as mutual information (MI) and correlation ratio (CR), appear to yield decent alignments when visually judged by matching outer brain contours. However, close inspection reveals that internal brain structures are often significantly misaligned. Poor registration is most evident in the ventricles and sulcal folds, where CSF is concentrated. This observation motivated our development of an improved modality-specific cost functional which uses a weighted local Pearson coefficient (LPC) to align T2- and T1-weighted images. In the absence of an alignment gold standard, we used three human observers blinded to registration method to provide an independent assessment of the quality of the registration for each cost functional. We found that LPC performed significantly better (p < 0.001) than generic cost functionals including MI and CR. Generic cost functionals were very often not minimal near the best alignment, thereby suggesting that optimization is not the cause of their failure. Lastly, we emphasize the importance of precise visual inspection of alignment quality and present an automated method for generating composite images that help capture errors of misalignment. JF - NeuroImage AU - Saad, Ziad S AU - Glen, Daniel R AU - Chen, Gang AU - Beauchamp, Michael S AU - Desai, Rutvik AU - Cox, Robert W AD - Scientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Dr. Room 1D80 Bethesda, MD 20892-1148 USA, rwcox@nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 839 EP - 848 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 44 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Transformation KW - Brain mapping KW - Cerebrospinal fluid KW - Functional magnetic resonance imaging KW - Automation KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20394441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=A+new+method+for+improving+functional-to-structural+MRI+alignment+using+local+Pearson+correlation&rft.au=Saad%2C+Ziad+S%3BGlen%2C+Daniel+R%3BChen%2C+Gang%3BBeauchamp%2C+Michael+S%3BDesai%2C+Rutvik%3BCox%2C+Robert+W&rft.aulast=Saad&rft.aufirst=Ziad&rft.date=2009-02-01&rft.volume=44&rft.issue=3&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.09.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Transformation; Brain mapping; Cerebrospinal fluid; Functional magnetic resonance imaging; Automation DO - http://dx.doi.org/10.1016/j.neuroimage.2008.09.037 ER - TY - JOUR T1 - Short-Term Inhalation Exposure to Mild Steel Welding Fume had no Effect on Lung Inflammation and Injury but did Alter Defense Responses to Bacteria in Rats AN - 20394015; 9067239 AB - Many workers worldwide are continually exposed to complex aerosols generated from welding processes. The objective was to assess the effect of inhalation exposure to mild steel (MS) welding fume on lung injury, inflammation, and defense responses. Male Sprague-Dawley rats were exposed to MS fume at a concentration of 40 mg/m3 t 3 h/day t 3 or 10 days using a robotic welding fume generator. Controls were exposed to filtered air. To assess lung defense responses, a group of animals were intratracheally inoculated with 5 t 104 Listeria monocytogenes 1 day after the last daily exposure. Welding particles were collected during exposure, and chemical composition and particle size were determined. After exposure, lung injury, inflammation, and host defense (bacterial clearance) were measured. The particles were composed of iron (80.6 %) and manganese (14.7 %) with a mass median aerodynamic diameter of 0.31 is a subset of m. No significant difference was observed in lung injury or inflammation after MS fume inhalation at 1, 4, and 11 days after the last exposure. However, there were significantly more bacteria at 3 days after infection in the lungs of the animals exposed to MS fume compared to air controls. Acute exposure of rats to MS fume had no effect on injury and inflammation, but suppressed lung defense responses after infection. More chronic inhalation studies are needed to further examine the immune effects and to elucidate the possible mechanisms of the suppressed lung defense response to infection associated with the inhalation of MS welding fume. JF - Inhalation Toxicology AU - Antonini, James M AU - Roberts, Jenny R AU - Stone, Sam AU - Chen, Bean T AU - Schwegler-Berry, Diane AU - Frazer, David G AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 182 EP - 192 PB - Taylor & Francis, 325 Chestnut Street Suite 800 Philadelphia PA 19106 USA, [URL:http://www.taylorandfrancis.com/] VL - 21 IS - 3 SN - 0895-8378, 0895-8378 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Inhalation KW - Listeria monocytogenes KW - Aerosols KW - Fumes KW - Injuries KW - Inflammation KW - Lung KW - Chronic infection KW - Welding KW - robotics KW - Steel KW - Iron KW - Manganese KW - J 02410:Animal Diseases KW - A 01450:Environmental Pollution & Waste Treatment KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20394015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+Toxicology&rft.atitle=Short-Term+Inhalation+Exposure+to+Mild+Steel+Welding+Fume+had+no+Effect+on+Lung+Inflammation+and+Injury+but+did+Alter+Defense+Responses+to+Bacteria+in+Rats&rft.au=Antonini%2C+James+M%3BRoberts%2C+Jenny+R%3BStone%2C+Sam%3BChen%2C+Bean+T%3BSchwegler-Berry%2C+Diane%3BFrazer%2C+David+G&rft.aulast=Antonini&rft.aufirst=James&rft.date=2009-02-01&rft.volume=21&rft.issue=3&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Inhalation+Toxicology&rft.issn=08958378&rft_id=info:doi/10.1080%2F08958370802360661 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inhalation; Aerosols; Fumes; Injuries; Lung; Chronic infection; Welding; robotics; Steel; Manganese; Iron; Inflammation; Listeria monocytogenes DO - http://dx.doi.org/10.1080/08958370802360661 ER - TY - JOUR T1 - Physical Activity and Esophageal and Gastric Carcinoma in a Large Prospective Study AN - 20337105; 9010987 AB - Abstract not available. JF - American Journal of Preventive Medicine AU - Leitzmann, Michael F AU - Koebnick, Corinna AU - Freedman, Neal D AU - Park, Yikyung AU - Ballard-Barbash, Rachel AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Abnet, Christian C AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, michael.leitzmann@klinik.uni-regensburg.de Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 112 EP - 119 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 36 IS - 2 SN - 0749-3797, 0749-3797 KW - Physical Education Index KW - Exercise KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20337105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Physical+Activity+and+Esophageal+and+Gastric+Carcinoma+in+a+Large+Prospective+Study&rft.au=Leitzmann%2C+Michael+F%3BKoebnick%2C+Corinna%3BFreedman%2C+Neal+D%3BPark%2C+Yikyung%3BBallard-Barbash%2C+Rachel%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian+C&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2009-02-01&rft.volume=36&rft.issue=2&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.09.033 LA - English DB - Physical Education Index N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Exercise DO - http://dx.doi.org/10.1016/j.amepre.2008.09.033 ER - TY - JOUR T1 - Gas-phase chemistry of benzyl alcohol: Reaction rate constants and products with OH radical and ozone AN - 20266349; 8871531 AB - A bimolecular rate constant, k sub(O) sub(H) sub(+) sub(B) sub(e) sub(n) sub(z) sub(y) sub(l) sub( ) sub(a) sub(l) sub(c) sub(o) sub(h) sub(o) sub(l), of (28+ /-7)x10 super(-) super(1) super(2)cm super(3)molecule super(-) super(1)s super(-) super(1) was measured using the relative rate technique for the reaction of the hydroxyl radical (OH) with benzyl alcohol, at (297+/-3)K and 1atm total pressure. Additionally, an upper limit of the bimolecular rate constant, k sub(O) sub(3) sub(+) sub(B) sub(e) sub(n) sub(z) sub(y) sub(l) sub( ) sub(a) sub(l) sub(c) sub(o) sub(h) sub(o) sub(l), of approximately 6x10 super(-) super(1) super(9)cm super(3)molecule super(-) super(1)s super(-) super(1) was determined by monitoring the decrease in benzyl alcohol concentration over time in an excess of ozone (O sub(3)). To more clearly define part of benzyl alcohol's indoor environment degradation mechanism, the products of the benzyl alcohol+OH were also investigated. The derivatizing agents O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine (PFBHA) and N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) were used to positively identify benzaldehyde, glyoxal and 4-oxopentanal as benzyl alcohol/OH reaction products. The elucidation of other reaction products was facilitated by mass spectrometry of the derivatized reaction products coupled with plausible benzyl alcohol /OH reaction mechanisms based on previously published volatile organic compound/OH gas-phase reaction mechanisms. JF - Atmospheric Environment AU - Harrison, J C AU - Wells, J R AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, ozw0@cdc.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 798 EP - 804 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 43 IS - 4 SN - 1352-2310, 1352-2310 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Alcohol KW - Ozone measurements KW - Atmospheric chemistry KW - Mass spectrometry KW - Hydroxyl photochemistry KW - Indoor environments KW - Volatile organic compounds KW - Hydroxyl radicals KW - Ozone KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20266349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Gas-phase+chemistry+of+benzyl+alcohol%3A+Reaction+rate+constants+and+products+with+OH+radical+and+ozone&rft.au=Harrison%2C+J+C%3BWells%2C+J+R&rft.aulast=Harrison&rft.aufirst=J&rft.date=2009-02-01&rft.volume=43&rft.issue=4&rft.spage=798&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2008.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Ozone measurements; Mass spectrometry; Hydroxyl photochemistry; Ozone; Alcohol; Atmospheric chemistry; Indoor environments; Volatile organic compounds; Hydroxyl radicals DO - http://dx.doi.org/10.1016/j.atmosenv.2008.11.001 ER - TY - JOUR T1 - Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract AN - 20252864; 8888904 AB - The association of kava product use with liver-related risks has prompted regulatory action in many countries. We studied the changes in gene expression of drug metabolizing enzymes in the livers of Fischer 344 male rats administered kava extract by gavage for 14 weeks. Analysis of 22,226 genes revealed that there were 14, 41, 110, 386, and 916 genes significantly changed in the 0.125, 0.25, 0.5, 1.0, and 2.0g/kg treatment groups, respectively. There were 16 drug metabolizing genes altered in all three high-dose treatment groups, among which seven genes belong to cytochrome P450 isozymes. While gene expression of Cyp1a1, 1a2, 2c6, 3a1, and 3a3 increased; Cyp 2c23 and 2c40 decreased, all in a dose-dependent manner. Real-time PCR analyses of several genes verified these results. Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, particularly the CYP isozymes, which could cause herb-drug interactions and may potentially lead to hepatotoxicity. JF - Food and Chemical Toxicology AU - Guo, L AU - Li, Q AU - Xia, Q AU - Dial, S AU - Chan, P C AU - Fu, P AD - National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079, USA, lei.guo@fda.hhs.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 433 EP - 442 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 47 IS - 2 SN - 0278-6915, 0278-6915 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Toxicology Abstracts KW - Gene expression KW - Isoenzymes KW - Liver KW - Enzymes KW - Polymerase chain reaction KW - Cytochrome P450 KW - Drugs KW - hepatotoxicity KW - X 24310:Pharmaceuticals KW - G 07710:Chemical Mutagenesis & Radiation KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20252864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Analysis+of+gene+expression+changes+of+drug+metabolizing+enzymes+in+the+livers+of+F344+rats+following+oral+treatment+with+kava+extract&rft.au=Guo%2C+L%3BLi%2C+Q%3BXia%2C+Q%3BDial%2C+S%3BChan%2C+P+C%3BFu%2C+P&rft.aulast=Guo&rft.aufirst=L&rft.date=2009-02-01&rft.volume=47&rft.issue=2&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2008.11.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Liver; Isoenzymes; Polymerase chain reaction; Enzymes; Cytochrome P450; Drugs; hepatotoxicity DO - http://dx.doi.org/10.1016/j.fct.2008.11.037 ER - TY - RPRT T1 - Injuries to Youth on Farms and Safety Recommendations, U.S. 2006 AN - 20191532; 10308231 AB - Understanding how to create a safe farm environment is important for farm operators and their families. Youth who live and work on farms are exposed to potentially dangerous farm-related hazards. JF - Injuries to Youth on Farms and Safety Recommendations, U.S. 2006. 439 pp. Feb 2009. AU - Anonymous Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 439 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA KW - Injuries KW - farms KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20191532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2009-02-01&rft.volume=&rft.issue=&rft.spage=439&rft.isbn=&rft.btitle=Injuries+to+Youth+on+Farms+and+Safety+Recommendations%2C+U.S.+2006&rft.title=Injuries+to+Youth+on+Farms+and+Safety+Recommendations%2C+U.S.+2006&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Comparing methods for detecting and characterizing metal oxide nanoparticles in unmodified commercial sunscreens AN - 1113214635; 17215609 AB - Aims: To determine if commercial sunscreens contain distinct nanoparticles and to evaluate analytical methods for their ability to detect and characterize nanoparticles in unmodified topical products using commercial sunscreens as a model. Methods: A total of 20 methods were evaluated for their ability to detect and characterize nanoparticles in unmodified commercial sunscreens. Results: Variable-pressure scanning-electron microscopy, atomic-force microscopy, laser-scanning confocal microscopy and X-ray diffraction were found to be viable and complementary methods for detecting and characterizing nanoparticles in sunscreens. Conclusions: It was determined that several of the commercial sunscreens contained distinct nanoparticles. No one method was able to completely characterize nanoparticles in the unmodified products but the viable methods provided complementary information regarding the nanoparticles and how they were interacting with the sunscreen matrix. JF - Nanomedicine AU - Tyner, Katherine M AU - Wokovich, Anna M AU - Doub, William H AU - Buhse, Lucinda F AU - Sung, Li-Piin AU - Watson, Stephanie S AU - Sadrieh, Nakissa AD - super(1)Center for Drug Evaluation & Research, FDA, Silver Spring, MD 20993, USA, nakissa.sadrieh@fda.hhs.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 145 EP - 159 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 4 IS - 2 SN - 1743-5889, 1743-5889 KW - Biotechnology and Bioengineering Abstracts KW - Confocal microscopy KW - Metals KW - Models KW - Sunscreens KW - X-ray diffraction KW - nanoparticles KW - nanotechnology KW - oxides KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1113214635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine&rft.atitle=Comparing+methods+for+detecting+and+characterizing+metal+oxide+nanoparticles+in+unmodified+commercial+sunscreens&rft.au=Tyner%2C+Katherine+M%3BWokovich%2C+Anna+M%3BDoub%2C+William+H%3BBuhse%2C+Lucinda+F%3BSung%2C+Li-Piin%3BWatson%2C+Stephanie+S%3BSadrieh%2C+Nakissa&rft.aulast=Tyner&rft.aufirst=Katherine&rft.date=2009-02-01&rft.volume=4&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Nanomedicine&rft.issn=17435889&rft_id=info:doi/10.2217%2F17435889.4.2.145 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Number of references - 27 N1 - Last updated - 2012-11-20 N1 - SubjectsTermNotLitGenreText - Metals; Confocal microscopy; oxides; Sunscreens; X-ray diffraction; nanoparticles; Models; nanotechnology DO - http://dx.doi.org/10.2217/17435889.4.2.145 ER - TY - CPAPER T1 - The Biodosimetry Program at the Biomedical Advanced Research and Development Authority T2 - 42nd Annual Midyear Meeting of the Health Physics Society AN - 41744194; 5025092 JF - 42nd Annual Midyear Meeting of the Health Physics Society AU - Grace, M AU - Moyer, B AU - Voigt, B AU - Homer, M AU - Macaluso, A AU - Manning, R Y1 - 2009/01/31/ PY - 2009 DA - 2009 Jan 31 KW - Research programs KW - Research KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41744194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=42nd+Annual+Midyear+Meeting+of+the+Health+Physics+Society&rft.atitle=The+Biodosimetry+Program+at+the+Biomedical+Advanced+Research+and+Development+Authority&rft.au=Grace%2C+M%3BMoyer%2C+B%3BVoigt%2C+B%3BHomer%2C+M%3BMacaluso%2C+A%3BManning%2C+R&rft.aulast=Grace&rft.aufirst=M&rft.date=2009-01-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=42nd+Annual+Midyear+Meeting+of+the+Health+Physics+Society&rft.issn=&rft_id=info:doi/ L2 - http://hps.org/documents/2009_midyear_program_preliminary.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Advisory Team for the Environment, Food and Health Activities and Initiatives T2 - 42nd Annual Midyear Meeting of the Health Physics Society AN - 41719143; 5025127 JF - 42nd Annual Midyear Meeting of the Health Physics Society AU - Noska, M Y1 - 2009/01/31/ PY - 2009 DA - 2009 Jan 31 KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41719143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=42nd+Annual+Midyear+Meeting+of+the+Health+Physics+Society&rft.atitle=The+Advisory+Team+for+the+Environment%2C+Food+and+Health+Activities+and+Initiatives&rft.au=Noska%2C+M&rft.aulast=Noska&rft.aufirst=M&rft.date=2009-01-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=42nd+Annual+Midyear+Meeting+of+the+Health+Physics+Society&rft.issn=&rft_id=info:doi/ L2 - http://hps.org/documents/2009_midyear_program_preliminary.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Sampling and analytical variability associated with the determination of total aflatoxins and ochratoxin A in powdered ginger sold as a dietary supplement in capsules. AN - 66838617; 19105639 AB - The U.S. Food and Drug Administration is studying the need to monitor dietary supplements for mycotoxins such as total aflatoxins and ochratoxin A. An effective mycotoxin-monitoring program requires knowledge of the sampling and analytical variability associated with the determination of total aflatoxins (AF) and ochratoxin A (OTA) in dietary supplements. Three lots of ginger sold as a powder in capsule form and packaged in individual bottles were analyzed for both AF and OTA. The total variability associated with measuring AF and OTA in powdered ginger was partitioned into bottle-to-bottle, within bottle, and analytical variances. The variances were estimated using a nested design. For AF and OTA, the within-bottle variance associated with the 5 g laboratory sample size was the largest component of variability accounting for about 43% and 85% of the total variance, respectively; the analytical variance accounted for about 34% and 9% of the total variability, respectively; and the bottle-to-bottle variance accounted for about 23% and 7% of the total variance, respectively. When the total variance is converted into the coefficient of variation (CV or standard deviation relative to the mean concentration), the CV is lower for AF (16.9%) than OTA (24.7%). JF - Journal of agricultural and food chemistry AU - Trucksess, Mary W AU - Whitaker, Thomas B AU - Weaver, Carol M AU - Slate, Andrew AU - Giesbrecht, Francis G AU - Rader, Jeanne I AU - Betz, Joseph M AD - U.S. Food and Drug Administration, College Park, Maryland, USA. Y1 - 2009/01/28/ PY - 2009 DA - 2009 Jan 28 SP - 321 EP - 325 VL - 57 IS - 2 KW - Aflatoxins KW - 0 KW - Capsules KW - Ochratoxins KW - ochratoxin A KW - 1779SX6LUY KW - Index Medicus KW - Analysis of Variance KW - Consumer Product Safety KW - Capsules -- chemistry KW - Ochratoxins -- analysis KW - Chromatography, High Pressure Liquid -- standards KW - Aflatoxins -- analysis KW - Ginger -- chemistry KW - Chromatography, High Pressure Liquid -- methods KW - Dietary Supplements -- analysis KW - Chromatography, High Pressure Liquid -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66838617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Sampling+and+analytical+variability+associated+with+the+determination+of+total+aflatoxins+and+ochratoxin+A+in+powdered+ginger+sold+as+a+dietary+supplement+in+capsules.&rft.au=Trucksess%2C+Mary+W%3BWhitaker%2C+Thomas+B%3BWeaver%2C+Carol+M%3BSlate%2C+Andrew%3BGiesbrecht%2C+Francis+G%3BRader%2C+Jeanne+I%3BBetz%2C+Joseph+M&rft.aulast=Trucksess&rft.aufirst=Mary&rft.date=2009-01-28&rft.volume=57&rft.issue=2&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Fjf8017854 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-13 N1 - Date created - 2009-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf8017854 ER - TY - RPRT T1 - 2009 Strategic Plan for Autism Spectrum Disorder Research. NIH Publication No. 09-7465 AN - 742876530; ED509368 AB - In response to the heightened societal concern over autism spectrum disorder (ASD), Congress passed the Combating Autism Act (CAA) of 2006 (P.L. 109-416). Through this Act, Congress intended to rapidly increase, accelerate the pace and improve coordination of scientific discovery in ASD research. The CAA requires the Interagency Autism Coordinating Committee (IACC) to develop and annually update a Strategic Plan for ASD research, including proposed budgetary requirements. Driven by both the sense of urgency and a spirit of collaboration, the IACC developed this initial Strategic Plan for ASD Research, which is focused on the unique needs of people with ASD and their families, as well as other consumers of these efforts. The Strategic Plan was developed through extensive and iterative input from members of the public, academic, and advocacy communities. In developing the Strategic Plan, the IACC: (1) Identified recent investments and accomplishments in ASD research; (2) Assessed the strengths, weaknesses, opportunities, and gaps in the ASD research enterprise; (3) Gathered ideas for research opportunities from a diverse group of stakeholders; (4) Convened four scientific workshops and solicited input from the public and non-government research sponsors to identify research opportunities; (5) Convened expert workgroups to recommend research objectives and strategies; and (6) Convened programmatic and agency experts to develop and recommend professional judgment budget estimates for each objective in the Plan. The Strategic Plan incorporates this array of input in two main sections. First, the foundation of the Plan--Vision, Mission, Core Values, and Crosscutting Themes--is described. The remainder of the Plan is organized around six critical questions asked by people and families living with ASD: (I) When should I be concerned?; (II) How can I understand what is happening?; (III) What caused this to happen and can this be prevented?; (IV) Which treatments and intervention will help?; (V) Where can I turn for services?; and (VI) What does the future hold? Each question is followed by a brief discussion of what is currently known and needed from research, an aspirational goal, research opportunities and objectives. This six-question framework was chosen by the IACC to emphasize the need for consumer-focused research that addresses the most pressing questions of people and families living with ASD, and to link these questions to specific research efforts. Y1 - 2009/01/26/ PY - 2009 DA - 2009 Jan 26 SP - 37 PB - Interagency Autism Coordinating Committee. US Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Workshops KW - Financial Support KW - Etiology KW - Clinical Diagnosis KW - Pervasive Developmental Disorders KW - Intervention KW - Federal Legislation KW - Agency Cooperation KW - Research Opportunities KW - Budgets KW - Research KW - Autism KW - Strategic Planning KW - Medical Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742876530?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - CPAPER T1 - A comparative study on non-confl uent and confl uent human malignant brain cancer metabolic response to He-Ne laser exposures: evidence for laser enhanced cellular production of H2O2 and laser induced "Bystander" effect T2 - IV Conference on Mechanisms for Low-Light Therapy (BO109) AN - 41755729; 5012810 JF - IV Conference on Mechanisms for Low-Light Therapy (BO109) AU - Tata, Darrell AU - Waynant, Ronald Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Lasers KW - Cancer KW - Comparative studies KW - Brain KW - Hydrogen peroxide KW - Metabolic response KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41755729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=IV+Conference+on+Mechanisms+for+Low-Light+Therapy+%28BO109%29&rft.atitle=A+comparative+study+on+non-confl+uent+and+confl+uent+human+malignant+brain+cancer+metabolic+response+to+He-Ne+laser+exposures%3A+evidence+for+laser+enhanced+cellular+production+of+H2O2+and+laser+induced+%22Bystander%22+effect&rft.au=Tata%2C+Darrell%3BWaynant%2C+Ronald&rft.aulast=Tata&rft.aufirst=Darrell&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=IV+Conference+on+Mechanisms+for+Low-Light+Therapy+%28BO109%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of methods for optical property determination in two-layer tissues T2 - II Conference on Design and Quality for Biomedical Technologies (BO114) AN - 41753787; 5013177 JF - II Conference on Design and Quality for Biomedical Technologies (BO114) AU - Wang, Quanzeng AU - Agrawal, Anant AU - Wang, Nam-Sun AU - Pfefer, T Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Optical properties KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41753787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=II+Conference+on+Design+and+Quality+for+Biomedical+Technologies+%28BO114%29&rft.atitle=Comparison+of+methods+for+optical+property+determination+in+two-layer+tissues&rft.au=Wang%2C+Quanzeng%3BAgrawal%2C+Anant%3BWang%2C+Nam-Sun%3BPfefer%2C+T&rft.aulast=Wang&rft.aufirst=Quanzeng&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=II+Conference+on+Design+and+Quality+for+Biomedical+Technologies+%28BO114%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Energy transfer-based biosensing of Botulinum neurotoxin A activity measured using an electroluminescent platform T2 - 2009 Conference on Frontiers in Pathogen Detection: From Nanosensors to Systems (BO111) AN - 41741158; 5012888 JF - 2009 Conference on Frontiers in Pathogen Detection: From Nanosensors to Systems (BO111) AU - Sapsford, Kim AU - Sun, Steven AU - Francis, Jesse AU - Kostov, Yordan AU - Rasooly, Avraham AU - Farrell, Dorothy AU - Mattoussi, Hedi AU - Medintz, Igor Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Neurotoxins KW - Botulinum toxin type A KW - Energy KW - Biosensors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41741158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Frontiers+in+Pathogen+Detection%3A+From+Nanosensors+to+Systems+%28BO111%29&rft.atitle=Energy+transfer-based+biosensing+of+Botulinum+neurotoxin+A+activity+measured+using+an+electroluminescent+platform&rft.au=Sapsford%2C+Kim%3BSun%2C+Steven%3BFrancis%2C+Jesse%3BKostov%2C+Yordan%3BRasooly%2C+Avraham%3BFarrell%2C+Dorothy%3BMattoussi%2C+Hedi%3BMedintz%2C+Igor&rft.aulast=Sapsford&rft.aufirst=Kim&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Frontiers+in+Pathogen+Detection%3A+From+Nanosensors+to+Systems+%28BO111%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Advanced confocal fiber-optic imaging and sensing approaches T2 - IX Conference on Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications (BO117) AN - 41734118; 5013261 JF - IX Conference on Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications (BO117) AU - Kim, Do-Hyun AU - Kang, Jin AU - Ilev, Ilko Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41734118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=IX+Conference+on+Optical+Fibers+and+Sensors+for+Medical+Diagnostics+and+Treatment+Applications+%28BO117%29&rft.atitle=Advanced+confocal+fiber-optic+imaging+and+sensing+approaches&rft.au=Kim%2C+Do-Hyun%3BKang%2C+Jin%3BIlev%2C+Ilko&rft.aulast=Kim&rft.aufirst=Do-Hyun&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=IX+Conference+on+Optical+Fibers+and+Sensors+for+Medical+Diagnostics+and+Treatment+Applications+%28BO117%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Contaminant Mass and Source Location Estimation using Limited Sample Data from CFD Results T2 - 2009 American Society of Heating, Refrigerating, and Air-Conditioning Engineers Winter Meeting AN - 41710349; 4993958 JF - 2009 American Society of Heating, Refrigerating, and Air-Conditioning Engineers Winter Meeting AU - Bennett, James AU - McKenna, Sean AU - Shulman, Stanley AU - Sieber, William Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Contaminants KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41710349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+American+Society+of+Heating%2C+Refrigerating%2C+and+Air-Conditioning+Engineers+Winter+Meeting&rft.atitle=Rapid+Contaminant+Mass+and+Source+Location+Estimation+using+Limited+Sample+Data+from+CFD+Results&rft.au=Bennett%2C+James%3BMcKenna%2C+Sean%3BShulman%2C+Stanley%3BSieber%2C+William&rft.aulast=Bennett&rft.aufirst=James&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+American+Society+of+Heating%2C+Refrigerating%2C+and+Air-Conditioning+Engineers+Winter+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://xp20.ashrae.org/conferenceprogram/Oct08TechProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Meeting current public health needs: optical biosensors for pathogen detection and analysis T2 - 2009 Conference on Frontiers in Pathogen Detection: From Nanosensors to Systems (BO111) AN - 41704135; 5012857 JF - 2009 Conference on Frontiers in Pathogen Detection: From Nanosensors to Systems (BO111) AU - Rasooly, Avraham Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Public health KW - Pathogens KW - Biosensors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41704135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Frontiers+in+Pathogen+Detection%3A+From+Nanosensors+to+Systems+%28BO111%29&rft.atitle=Meeting+current+public+health+needs%3A+optical+biosensors+for+pathogen+detection+and+analysis&rft.au=Rasooly%2C+Avraham&rft.aulast=Rasooly&rft.aufirst=Avraham&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Frontiers+in+Pathogen+Detection%3A+From+Nanosensors+to+Systems+%28BO111%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs. AN - 66852547; 19042103 AB - Two analogues of sildenafil were detected in herbal dietary supplements marketed as aphrodisiacs. Both compounds were identified as thioketone analogues of sildenafil in which the carbonyl group in the pyrimidine ring of sildenafil was substituted with a thiocarbonyl group. The first compound was identified as thiosildenafil, a compound that has recently been reported as an adulterant in health supplements. The structure of the second compound was established using LC-MS, UV spectroscopy, ESI-MS(n), NMR and a hydrolytic process. A detailed study of the hydrolysis products of sildenafil, thiosildenafil, and the second unknown compound proved that the second compound, named thiomethisosildenafil, had a structure analogous to sildenafil in which the N-methylpiperazine moiety had been replaced with 2,6-dimethylpiperazine and the oxygen atom of the carbonyl group in the heterocyclic ring had been replaced with a sulfur atom. Under the hydrolytic reaction conditions employed in this study, thioketones hydrolyze to ketones (e.g., thiosildenafil-->sildenafil), making this a valuable technique for the structure elucidation of thiosildenafil analogues. Ten herbal dietary supplements, each as a capsule dosage form, were found to contain 8-151 mg of thiomethisosildenafil per capsule, and one herbal dietary supplement was found to contain 35 mg of thiosildenafil per capsule. JF - Journal of pharmaceutical and biomedical analysis AU - Reepmeyer, John C AU - d'Avignon, D André AD - US Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St. Louis, MO 63101, USA. john.reepmeyer@fda.hhs.gov Y1 - 2009/01/15/ PY - 2009 DA - 2009 Jan 15 SP - 145 EP - 150 VL - 49 IS - 1 SN - 0731-7085, 0731-7085 KW - Aphrodisiacs KW - 0 KW - Ketones KW - Phosphodiesterase Inhibitors KW - Piperazines KW - Purines KW - Pyrimidines KW - Sulfones KW - thiomethisosildenafil KW - thiosildenafil KW - Sildenafil Citrate KW - BW9B0ZE037 KW - Index Medicus KW - Molecular Structure KW - Pyrimidines -- chemistry KW - Spectrometry, Mass, Electrospray Ionization KW - Humans KW - Spectrophotometry, Ultraviolet -- methods KW - Hydrolysis KW - Phosphodiesterase Inhibitors -- chemistry KW - Chromatography, Liquid -- methods KW - Erectile Dysfunction -- diet therapy KW - Nuclear Magnetic Resonance, Biomolecular KW - Mass Spectrometry -- methods KW - Purines -- chemistry KW - Dietary Supplements -- analysis KW - Male KW - Sulfones -- chemistry KW - Ketones -- isolation & purification KW - Piperazines -- chemistry KW - Drug Contamination KW - Ketones -- chemistry KW - Food Contamination KW - Aphrodisiacs -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66852547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+and+biomedical+analysis&rft.atitle=Structure+elucidation+of+thioketone+analogues+of+sildenafil+detected+as+adulterants+in+herbal+aphrodisiacs.&rft.au=Reepmeyer%2C+John+C%3Bd%27Avignon%2C+D+Andr%C3%A9&rft.aulast=Reepmeyer&rft.aufirst=John&rft.date=2009-01-15&rft.volume=49&rft.issue=1&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+and+biomedical+analysis&rft.issn=07317085&rft_id=info:doi/10.1016%2Fj.jpba.2008.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-02 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jpba.2008.10.007 ER - TY - JOUR T1 - Preliminary reservoir model of enhanced coalbed methane (ECBM) in a subbituminous coal seam, Huntly Coalfield, New Zealand AN - 742893493; 2010-012100 AB - The Huntly coalfield has significant coal deposits that contain biogenically-sourced methane. The coals are subbituminous in rank and Eocene in age and have been previously characterised with relatively low to moderate measured gas (CH (sub 4) ) contents (2-4 m (super 3) /ton). The CO (sub 2) holding capacity is relatively high (18.0 m (super 3) /ton) compared with that of CH (sub 4) (2.6 m (super 3) /ton) and N (sub 2) (0.7 m (super 3) /ton) at the same pressure (4 MPa; all as received basis). The geothermal gradient is also quite high at 55 degrees C/km. A study has been conducted which simulates enhancement of methane recovery (ECBM) from these deposits using a new version of the TOUGH2 (version 2) reservoir simulator (ECBM-TOUGH2) that can handle non-isothermal, multi-phase flows of mixtures of water, CH (sub 4) , CO (sub 2) and N (sub 2) . The initial phase of the simulation is CH (sub 4) production for the first 5 years of the field history. The model indicates that methane production can be significantly improved (from less than 80% recovery to nearly 90%) through injection of CO (sub 2) . However, although an increase in the rate of CO (sub 2) injection increases the amount of CO (sub 2) sequestered, the methane recovery (because of earlier breakthrough with increasing injection rate) decreases. Modeling of pure N (sub 2) injection produced little enhanced CH (sub 4) production. The injection of a hypothetical flue gas mixture (CO (sub 2) and N (sub 2) ) also produced little increase in CH (sub 4) production. This is related to the low adsorption capacity of the Huntly coal to N (sub 2) which results in almost instantaneous breakthrough into the production well. Abstract Copyright (2009) Elsevier, B.V. JF - International Journal of Coal Geology AU - Zarrouk, Sadiq J AU - Moore, Tim A Y1 - 2009/01/07/ PY - 2009 DA - 2009 Jan 07 SP - 153 EP - 161 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - TOUGH2 KW - natural gas KW - petroleum KW - simulation KW - physical models KW - North Island KW - bituminous coal KW - reservoir rocks KW - nitrogen KW - carbon dioxide KW - Cenozoic KW - sedimentary rocks KW - coal KW - Australasia KW - Eocene KW - enhanced recovery KW - Paleogene KW - gases KW - computer programs KW - Tertiary KW - coalbed methane KW - Waikato Basin KW - New Zealand KW - Huntly KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742893493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Preliminary+reservoir+model+of+enhanced+coalbed+methane+%28ECBM%29+in+a+subbituminous+coal+seam%2C+Huntly+Coalfield%2C+New+Zealand&rft.au=Zarrouk%2C+Sadiq+J%3BMoore%2C+Tim+A&rft.aulast=Zarrouk&rft.aufirst=Sadiq&rft.date=2009-01-07&rft.volume=77&rft.issue=1-2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.08.007 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-10-18 N1 - SubjectsTermNotLitGenreText - Australasia; bituminous coal; carbon dioxide; Cenozoic; coal; coalbed methane; computer programs; enhanced recovery; Eocene; gases; Huntly; natural gas; New Zealand; nitrogen; North Island; Paleogene; petroleum; physical models; reservoir rocks; sedimentary rocks; simulation; Tertiary; TOUGH2; Waikato Basin DO - http://dx.doi.org/10.1016/j.coal.2008.08.007 ER - TY - JOUR T1 - Pathways into homelessness: recently homeless adults problems and service use before and after becoming homeless in Amsterdam. AN - 66830173; 19128448 AB - To improve homelessness prevention practice, we met with recently homeless adults, to explore their pathways into homelessness, problems and service use, before and after becoming homeless. Recently homeless adults (last housing lost up to two years ago and legally staying in the Netherlands) were sampled in the streets, day centres and overnight shelters in Amsterdam. In April and May 2004, students conducted interviews and collected data on demographics, self reported pathways into homelessness, social and medical problems, and service use, before and after becoming homeless. among 120 recently homeless adults, (male 88%, Dutch 50%, average age 38 years, mean duration of homelessness 23 weeks), the main reported pathways into homelessness were evictions 38%, relationship problems 35%, prison 6% and other reasons 22%. Compared to the relationship group, the eviction group was slightly older (average age 39.6 versus 35.5 years; p = 0.08), belonged more often to a migrant group (p = 0.025), and reported more living single (p < 0,001), more financial debts (p = 0.009), more alcohol problems (p = 0.048) and more contacts with debt control services (p = 0.009). The relationship group reported more domestic conflicts (p < 0.001) and tended to report more drug (cocaine) problems. Before homelessness, in the total group, contacts with any social service were 38% and with any medical service 27%. Despite these contacts they did not keep their house. During homelessness only contacts with social work and benefit agencies increased, contacts with medical services remained low. the recently homeless fit the overall profile of the homeless population in Amsterdam: single (Dutch) men, around 40 years, with a mix of financial debts, addiction, mental and/or physical health problems. Contacts with services were fragmented and did not prevent homelessness. For homelessness prevention, systematic and outreach social medical care before and during homelessness should be provided. JF - BMC public health AU - van Laere, Igor R AU - de Wit, Matty A AU - Klazinga, Niek S AD - GGD Municipal Public Health Service, Amsterdam, the Netherlands. ivlaere@ggd.amsterdam.nl Y1 - 2009/01/07/ PY - 2009 DA - 2009 Jan 07 SP - 3 VL - 9 KW - Index Medicus KW - Netherlands -- epidemiology KW - Analysis of Variance KW - Marital Status -- statistics & numerical data KW - Chi-Square Distribution KW - Humans KW - Mental Disorders -- epidemiology KW - Needs Assessment KW - Single Person -- statistics & numerical data KW - Socioeconomic Factors KW - Cross-Sectional Studies KW - Logistic Models KW - Risk Factors KW - Adult KW - Alcoholism KW - Surveys and Questionnaires KW - Middle Aged KW - Social Problems KW - Urban Population KW - Statistics, Nonparametric KW - Female KW - Male KW - Homeless Persons -- statistics & numerical data KW - Public Health Practice KW - Social Welfare -- statistics & numerical data KW - Homeless Persons -- psychology KW - Poverty -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66830173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+public+health&rft.atitle=Pathways+into+homelessness%3A+recently+homeless+adults+problems+and+service+use+before+and+after+becoming+homeless+in+Amsterdam.&rft.au=van+Laere%2C+Igor+R%3Bde+Wit%2C+Matty+A%3BKlazinga%2C+Niek+S&rft.aulast=van+Laere&rft.aufirst=Igor&rft.date=2009-01-07&rft.volume=9&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=BMC+public+health&rft.issn=1471-2458&rft_id=info:doi/10.1186%2F1471-2458-9-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-22 N1 - Date created - 2009-01-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Gen Intern Med. 1999 Oct;14(10):599-605 [10571704] Scand J Public Health. 2009 Sep;37(7):697-705 [19666669] Issues Ment Health Nurs. 2000 Sep;21(6):581-604 [11271135] Ned Tijdschr Geneeskd. 2001 Jun 16;145(24):1156-60 [11433664] Psychiatr Serv. 2002 Nov;53(11):1472-4 [12407279] Ann Intern Med. 1997 Jun 15;126(12):973-5 [9182475] J Gerontol B Psychol Sci Soc Sci. 2005 May;60(3):S152-9 [15860792] Am J Prev Med. 2005 Nov;29(4):311-9 [16242595] Health Soc Care Community. 2006 Mar;14(2):156-66 [16460365] Br J Community Nurs. 2006 Apr;11(4):157-61 [16723906] BMC Fam Pract. 2006;7:58 [17044914] Am J Public Health. 2007 Mar;97(3):464-9 [17267724] J Adv Nurs. 2007 May;58(3):273-81 [17474916] Aust N Z J Public Health. 2007 Jun;31(3):252-8 [17679244] Eur J Public Health. 2008 Feb;18(1):5-6 [18211914] Br J Gen Pract. 2008 May;58(550):367 [18482499] Health Soc Care Community. 2009 Feb;17(1):1-8 [19125966] Psychiatr Serv. 2000 Jan;51(1):100-4 [10647141] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2458-9-3 ER - TY - JOUR T1 - Adverse events after anthrax vaccination reported to the Vaccine Adverse Event Reporting System (VAERS), 1990-2007. AN - 66740593; 18992783 AB - During the period March 1, 1998 to January 14, 2007, approximately 6 million doses of Anthrax vaccine adsorbed (AVA) vaccine were administered. As of January 16, 2007, 4753 reports of adverse events following receipt of AVA vaccination had been submitted to the Vaccine Adverse Event Reporting System (VAERS). Taken together, reports to VAERS did not definitively link any serious unexpected risk to this vaccine, and review of death and serious reports did not show a distinctive pattern indicative of a causal relationship to AVA vaccination. Continued monitoring of VAERS and analysis of potential associations between AVA vaccination and rare, serious events is warranted. JF - Vaccine AU - Niu, Manette T AU - Ball, Robert AU - Woo, Emily Jane AU - Burwen, Dale R AU - Knippen, Maureen AU - Braun, M Miles AU - VAERS Working Group AD - Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Biostatistics and Epidemiology, Division of Epidemiology, Vaccine Safety Branch, 1401 Rockville Pike, HFM-220, Rockville, MD 20852, United States. manette.niu@fda.hhs.gov ; VAERS Working Group Y1 - 2009/01/07/ PY - 2009 DA - 2009 Jan 07 SP - 290 EP - 297 VL - 27 IS - 2 SN - 0264-410X, 0264-410X KW - Anthrax Vaccines KW - 0 KW - Vaccines KW - Index Medicus KW - United States KW - Young Adult KW - Humans KW - Adult KW - Product Surveillance, Postmarketing KW - Bayes Theorem KW - Middle Aged KW - Vaccination -- adverse effects KW - Male KW - Female KW - Vaccines -- adverse effects KW - Drug-Related Side Effects and Adverse Reactions KW - Anthrax Vaccines -- adverse effects KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Anthrax -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66740593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Adverse+events+after+anthrax+vaccination+reported+to+the+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29%2C+1990-2007.&rft.au=Niu%2C+Manette+T%3BBall%2C+Robert%3BWoo%2C+Emily+Jane%3BBurwen%2C+Dale+R%3BKnippen%2C+Maureen%3BBraun%2C+M+Miles%3BVAERS+Working+Group&rft.aulast=Niu&rft.aufirst=Manette&rft.date=2009-01-07&rft.volume=27&rft.issue=2&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.10.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-17 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Vaccine. 2009 Nov 12;27(48):6654-5 [19716457] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.vaccine.2008.10.044 ER - TY - JOUR T1 - Case StudiesEvaluation of Chemical Hazards at a Criminal Investigation Section of a Police Department AN - 899167157; 15153606 JF - Journal of Occupational and Environmental Hygiene AU - Fent, Kenneth W AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Hazards KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & ENAironmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899167157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Case+StudiesEvaluation+of+Chemical+Hazards+at+a+Criminal+Investigation+Section+of+a+Police+Department&rft.au=Fent%2C+Kenneth+W&rft.aulast=Fent&rft.aufirst=Kenneth&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2010.509843 L2 - http://www.informaworld.com/smpp/content~db=all~content=a926134629~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Hazards DO - http://dx.doi.org/10.1080/15459624.2010.509843 ER - TY - JOUR T1 - Correcting Diacetyl Concentrations from Air Samples Collected with NIOSH Method 2557 AN - 899154135; 15153641 AB - Diacetyl (2,3-butanedione), a diketone chemical used to impart a buttery taste in many flavoring mixtures, has been associated with bronchiolitis obliterans in several industrial settings. For workplace evaluations in 2000-2006, National Institute for Occupational Safety and Health (NIOSH) investigators used NIOSH Method 2557, a sampling and analytical method for airborne diacetyl utilizing carbon molecular sieve sorbent tubes. The method was subsequently suspected to progressively underestimate diacetyl concentrations with increasing sampling site humidity. Since underestimation of worker exposure may lead to overestimation of respiratory health risk in quantitative exposure-effect analyses, correction of the diacetyl concentrations previously reported with Method 2557 is essential. We studied the effects of humidity and sample storage duration on recovery of diacetyl from experimental air samples taken from a dynamically generated controlled test atmosphere that allowed control of diacetyl concentration, temperature, relative humidity, sampling duration, and sampling flow rate. Samples were analyzed with Method 2557, and results were compared with theoretical test atmosphere diacetyl concentration. After fitting nonlinear models to the experimental data, we found that absolute humidity, diacetyl concentration, and days of sample storage prior to extraction affected diacetyl recovery as did sampling flow rate to a much smaller extent. We derived a mathematical correction procedure to more accurately estimate historical workplace diacetyl concentration based on laboratory-reported concentrations of diacetyl using Method 2557, and sample site temperature and relative humidity (to calculate absolute humidity), as well as days of sample storage prior to extraction in the laboratory. With this correction procedure, quantitative risk assessment for diacetyl can proceed using corrected exposure levels for air samples previously collected and analyzed using NIOSH Method 2557 for airborne diacetyl. JF - Journal of Occupational and Environmental Hygiene AU - Cox-Ganser, Jean AU - Ganser, Gary AU - Saito, Rena AU - Hobbs, Gerald AU - Boylstein, Randy AU - Hendricks, Warren AU - Simmons, Michael AU - Eide, Mary AU - Kullman, Greg AU - Piacitelli, Chris AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Storage KW - Risk assessment KW - Air sampling KW - Temperature KW - Humidity KW - absolute humidity KW - Atmosphere KW - Flow rates KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899154135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+Annual+Meeting+of+the+American+Society+of+Human+Genetics+%28ASHG+2008%29&rft.atitle=Establishing+the+electronic+pathways+to+support+personalized+medicine&rft.au=Downing%2C+G&rft.aulast=Downing&rft.aufirst=G&rft.date=2008-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Human+Genetics+%28ASHG+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.informaworld.com/smpp/content~db=all~content=a932230552~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Risk assessment; Storage; Temperature; Air sampling; Humidity; absolute humidity; Atmosphere; Occupational exposure; Flow rates DO - http://dx.doi.org/10.1080/15459624.2011.540168 ER - TY - JOUR T1 - Laboratory Evaluation to Reduce Respirable Crystalline Silica Dust When Cutting Concrete Roofing Tiles Using a Masonry Saw AN - 899148835; 15153561 AB - Respirable crystalline silica dust exposure in residential roofers is a recognized hazard resulting from cutting concrete roofing tiles. Roofers cutting tiles using masonry saws can be exposed to high concentrations of respirable dust. Silica exposures remain a serious threat for nearly two million U.S. construction workers. Although it is well established that respiratory diseases associated with exposure to silica dust are preventable, they continue to occur and cause disability or death. The effectiveness of both a commercially available local exhaust ventilation (LEV) system and a water suppression system in reducing silica dust was evaluated separately. The LEV system exhausted 0.2,0.13, or 0.12 m3/sec of dust laden air, while the water suppression system supplied 0.1,0.0,0.03, or 0.02 L/sec of water to the saw blade. Using a randomized block design, implemented under laboratory conditions, the aforementioned conditions were evaluated independently on two types of concrete roofing tiles (s-shape and flat) using the same saw and blade. Each engineering control (LEV or water suppression) was replicated eight times, or four times for each type of tile. Analysis of variance was performed by comparing the mean airborne respirable dust concentrations generated during each run and engineering control treatment. The use of water controls and ventilation controls compared with the 'no control' treatment resulted in a statistically significant (p < 0.05) reduction of mean respirable dust concentrations generated per tile cut. The percent reduction for respirable dust concentrations was 99% for the water control and 91% for the LEV. Results suggest that water is an effective method for reducing crystalline silica exposures. However, water damage potential, surface discolorations, cleanup, slip hazards, and other requirements may make the use of water problematic in many situations. Concerns with implementing an LEV system to control silica dust exposures include sufficient capture velocity, additional weight of the saw with the LEV system, electricity connections, and cost of air handling unit. JF - Journal of Occupational and Environmental Hygiene AU - Carlo, Rebecca V AU - Sheehy, John AU - Feng, H Amy AU - Sieber, William K AD - Health and Safety (formerly National Institute for Occupational Safety and Health, Division of Applied Research and Technology), ICU Environmental, Houston, Texas Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Mortality KW - USA KW - Ventilation KW - disabilities KW - silica KW - Velocity KW - Respiratory diseases KW - Concrete KW - Dust KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899148835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Laboratory+Evaluation+to+Reduce+Respirable+Crystalline+Silica+Dust+When+Cutting+Concrete+Roofing+Tiles+Using+a+Masonry+Saw&rft.au=Carlo%2C+Rebecca+V%3BSheehy%2C+John%3BFeng%2C+H+Amy%3BSieber%2C+William+K&rft.aulast=Carlo&rft.aufirst=Rebecca&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903579695 L2 - http://www.informaworld.com/smpp/content~db=all~content=a919348461~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Mortality; disabilities; Ventilation; silica; Velocity; Respiratory diseases; Concrete; Dust; USA DO - http://dx.doi.org/10.1080/15459620903579695 ER - TY - JOUR T1 - Evaluation of the Filtration Performance of NIOSH-Approved N95 Filtering Facepiece Respirators by Photometric and Number-Based Test Methods AN - 899148159; 15153636 AB - N95 particulate filtering facepiece respirators are certified by measuring penetration levels photometrically with a presumed severe case test method using charge neutralized NaCl aerosols at 85 L/min. However, penetration values obtained by photometric methods have not been compared with count-based methods using contemporary respirators composed of electrostatic filter media and challenged with both generated and ambient aerosols. To better understand the effects of key test parameters (e.g., particle charge, detection method), initial penetration levels for five N95 model filtering facepiece respirators were measured using NaCl aerosols with the aerosol challenge and test equipment employed in the NIOSH respirator certification method (photometric) and compared with an ultrafine condensation particle counter method (count based) for the same NaCl aerosols as well as for ambient room air particles. Penetrations using the NIOSH test method were several-fold less than the penetrations obtained by the ultrafine condensation particle counter for NaCl aerosols as well as for room particles indicating that penetration measurement based on particle counting offers a more difficult challenge than the photometric method, which lacks sensitivity for particles < 100 nm. All five N95 models showed the most penetrating particle size around 50 nm for room air particles with or without charge neutralization, and at 200 nm for singly charged NaCl monodisperse particles. Room air with fewer charged particles and an overwhelming number of neutral particles contributed to the most penetrating particle size in the 50 nm range, indicating that the charge state for the majority of test particles determines the MPPS. Data suggest that the NIOSH respirator certification protocol employing the photometric method may not be a more challenging aerosol test method. Filter penetrations can vary among workplaces with different particle size distributions, which suggests the need for the development of new or revised 'more challenging' aerosol test methods for NIOSH certification of respirators. JF - Journal of Occupational and Environmental Hygiene AU - Rengasamy, Samy AU - Miller, Adam AU - Eimer, Benjamin C AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Particle size KW - certification KW - Aerosols KW - Filtration KW - test equipment KW - Particulates KW - Respirators KW - Protective equipment KW - particle counters KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899148159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Evaluation+of+the+Filtration+Performance+of+NIOSH-Approved+N95+Filtering+Facepiece+Respirators+by+Photometric+and+Number-Based+Test+Methods&rft.au=Rengasamy%2C+Samy%3BMiller%2C+Adam%3BEimer%2C+Benjamin+C&rft.aulast=Rengasamy&rft.aufirst=Samy&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2010.515556 L2 - http://www.informaworld.com/smpp/content~db=all~content=a930961797~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Particle size; certification; Filtration; Aerosols; test equipment; Particulates; Respirators; particle counters; Protective equipment DO - http://dx.doi.org/10.1080/15459624.2010.515556 ER - TY - JOUR T1 - Physiological Effects of Boot Weight and Design on Men and Women Firefighters AN - 899148082; 15153596 AB - {/ampp/image?path=/713657996/922680663/uoeh_a_486285_o_ilm0002.png } (~3.5%) in men only. Mean increases in metabolic and respiratory variables per 1-kg increase in boot weight were in the 5 to 12% range observed previously for men during treadmill walking but were considerably smaller for women. Mean increases in oxygen consumption during stair ergometry were statistically significant but were smaller in the current study than previously observed and may not be practically significant. There was no significant effect of boot design in addition to boot weight for either mode of exercise. JF - Journal of Occupational and Environmental Hygiene AU - Turner, Nina L AU - Chiou, Sharon AU - Zwiener, Joyce AU - Weaver, Darlene AU - Spahr, James AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Oxygen consumption KW - firefighter services KW - Physiology KW - males KW - Females KW - Design KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899148082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Physiological+Effects+of+Boot+Weight+and+Design+on+Men+and+Women+Firefighters&rft.au=Turner%2C+Nina+L%3BChiou%2C+Sharon%3BZwiener%2C+Joyce%3BWeaver%2C+Darlene%3BSpahr%2C+James&rft.aulast=Turner&rft.aufirst=Nina&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2010.486285 L2 - http://www.informaworld.com/smpp/content~db=all~content=a922680663~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Oxygen consumption; firefighter services; Physiology; males; Females; Design DO - http://dx.doi.org/10.1080/15459624.2010.486285 ER - TY - JOUR T1 - Analytical Performance IssuesIntegrating Direct-Reading Exposure Assessment Methods into Industrial Hygiene Practice AN - 899146590; 15153664 JF - Journal of Occupational and Environmental Hygiene AU - Pearce, Terri AU - Coffey, Christopher AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Hygiene KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & ENAironmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899146590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Analytical+Performance+IssuesIntegrating+Direct-Reading+Exposure+Assessment+Methods+into+Industrial+Hygiene+Practice&rft.au=Pearce%2C+Terri%3BCoffey%2C+Christopher&rft.aulast=Pearce&rft.aufirst=Terri&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2011.569314 L2 - http://www.informaworld.com/smpp/content~db=all~content=a936031652~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Hygiene DO - http://dx.doi.org/10.1080/15459624.2011.569314 ER - TY - JOUR T1 - Physiological Monitoring in Firefighter Ensembles: Wearable Plethysmographic Sensor Vest versus Standard Equipment AN - 899145911; 15153543 AB - We evaluated the accuracy of a wearable sensor vest for real-time monitoring of physiological responses to treadmill exercise. Ten subjects in standard firefighter ensembles, treadmill exercising at 50% VO2 max, had heart rate (HR), respiratory rate (RR), skin temperature (Tsk), oxygen saturation (SaO2), tidal volume (VT), and minute ventilation ((E) recorded concurrently by a wearable plethysmographic sensor vest and standard laboratory physiological monitoring equipment for comparison. A high degree of correlation was noted for most of the measured variables [HR (r = 0.99), RR (r = 0.98), Tsk (r = 0.98), (E (r = 0.88), and SaO2 (r = 0.79)]. VT (r = 0.60) had a moderate correlation, although a paired differences analysis showed a mean paired difference of -0.03 L. This mean paired difference represents a 1.92% variation for VT. Data from the wearable sensor vest is comparable to data captured from standard laboratory physiological monitoring equipment on subjects wearing standard firefighter ensembles while exercising at a moderate work rate. This study demonstrates the accuracy of the wearable sensor technology for these physiological parameters under these conditions and suggests that it could be useful for actual field studies of firefighters in traditional firefighting gear. JF - Journal of Occupational and Environmental Hygiene AU - Coca, Aitor AU - Roberge, Raymond J AU - Williams, W Jon AU - Landsittel, Douglas P AU - Powell, Jeffrey B AU - Palmiero, Andrew AD - National Personal Protective Technology Laboratory/National Institute for Occupational Safety and Health/Centers for Disease Control and Prevention, Pittsburgh, Pennsylvania Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Oxygen KW - Skin KW - Sensors KW - firefighter services KW - Ventilation KW - heart rate KW - Physiology KW - Physiological responses KW - Technology KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899145911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Physiological+Monitoring+in+Firefighter+Ensembles%3A+Wearable+Plethysmographic+Sensor+Vest+versus+Standard+Equipment&rft.au=Coca%2C+Aitor%3BRoberge%2C+Raymond+J%3BWilliams%2C+W+Jon%3BLandsittel%2C+Douglas+P%3BPowell%2C+Jeffrey+B%3BPalmiero%2C+Andrew&rft.aulast=Coca&rft.aufirst=Aitor&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903455722 L2 - http://www.informaworld.com/smpp/content~db=all~content=a917840546~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Oxygen; Skin; Ventilation; firefighter services; Sensors; heart rate; Physiological responses; Physiology; Technology DO - http://dx.doi.org/10.1080/15459620903455722 ER - TY - JOUR T1 - Proceedings of the Third International Symposium on Beryllium Particulates and Their Detection November 17-19, 2008, Albuquerque, New Mexico AN - 899145775; 15153513 JF - Journal of Occupational and Environmental Hygiene AU - Ashley, Kevin AU - Ekechukwu, Amy AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Beryllium KW - USA, New Mexico KW - Particulates KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & ENAironmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899145775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Proceedings+of+the+Third+International+Symposium+on+Beryllium+Particulates+and+Their+Detection+November+17-19%2C+2008%2C+Albuquerque%2C+New+Mexico&rft.au=Ashley%2C+Kevin%3BEkechukwu%2C+Amy&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903158607 L2 - http://www.informaworld.com/smpp/content~db=all~content=a916671120~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Particulates; USA, New Mexico DO - http://dx.doi.org/10.1080/15459620903158607 ER - TY - JOUR T1 - A Comparison of Assessment Methods of Hand Activity and Force for Use in Calculating the ACGIH registered Hand Activity Level (HAL) TLV registered AN - 899142230; 15153587 AB - This article compares several methods that were used for determining hand activity level and force in a large prospective ergonomics study. The first goal of this analysis was to determine the degree of correlation between hand activity/ force ratings using different assessment methods. The second goal was to determine if the hand activity/force methods were functionally equivalent for the purpose of calculating the ACGIH registered hand activity level (HAL) threshold limit value (TLV registered ). A final goal was to investigate reasons for potential differences between methods. More than 700 task analyses were conducted on 484 workers at three study locations. Hand activity was assessed by two methods, including a trained observer on site using a 10-point visual analog scale for hand activity level and by offsite video analysis of the same task to calculate the frequency of exertions and the work/recovery ratio. Hand force was assessed by two on-site methods: ratings of perceived exertion (RPE) using a modified Borg CR-10 scale by a trained observer and RPE by the worker performing the task. The two methods for assessing hand activity level were correlated (Spearman rank = 0.49) and produced main TLV result categories (below Action Limit, Action Limit, TLV) with percent of exact agreement ranging from 71 to 91% and weighted Kappa ranging from 0.61 to 0.75. The two RPE methods for assessing hand force were correlated (Spearman rank ranging from 0.47 to 0.69) and produced TLVs with percent of exact agreement ranging from 64 to 83% and weighted Kappa ranging from 0.52 to 0.62. Differences between methods may be explained by a number of task and subject variables that were significantly associated with higher levels of hand activity and force. In summary, this study found substantial agreement between two methods for assessing hand activity level and moderate agreement between two methods for assessing hand force. JF - Journal of Occupational and Environmental Hygiene AU - Wurzelbacher, Steve AU - Burt, Susan AU - Crombie, Ken AU - Ramsey, Jessica AU - Luo, Lian AU - Allee, Steve AU - Jin, Yan AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Perception KW - Threshold limits KW - Ergonomics KW - working conditions KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899142230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=A+Comparison+of+Assessment+Methods+of+Hand+Activity+and+Force+for+Use+in+Calculating+the+ACGIH+registered+Hand+Activity+Level+%28HAL%29+TLV+registered&rft.au=Wurzelbacher%2C+Steve%3BBurt%2C+Susan%3BCrombie%2C+Ken%3BRamsey%2C+Jessica%3BLuo%2C+Lian%3BAllee%2C+Steve%3BJin%2C+Yan&rft.aulast=Wurzelbacher&rft.aufirst=Steve&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2010.481171 L2 - http://www.informaworld.com/smpp/content~db=all~content=a921904029~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Perception; Threshold limits; working conditions; Ergonomics DO - http://dx.doi.org/10.1080/15459624.2010.481171 ER - TY - JOUR T1 - ErgonomicsUsing Ergonomics to Enhance Safe Production at a Surface Coal Mine -- A Case Study with Powder Crews AN - 899140576; 15153494 AB - Job tasks that involve exposure to work-related musculoskeletal disorder (WMSD) risk factors may impact both the risk of injury and production downtime. Common WMSD risks factors associated with mining tasks include forceful exertions, awkward postures, repetitive motion, jolting and jarring, forceful gripping, contact stress, and whole body and segmental vibration. Mining environments that expose workers to temperature/humidity extremes, windy conditions, and slippery and uneven walking surfaces also contribute to injury risk. National Institute for Occupational Safety and Health (NIOSH) researchers worked with powder crew members from the Bridger Coal Company to identify and rank routine work tasks based on perceived exposure to WMSD risk factors. This article presents the process followed to identify tasks that workers believed involved the greatest exposure to risk factors and discusses risk reduction strategies. Specifically, the proposed prill truck design changes addressed cab ingress/egress, loading blast holes, and access to the upper deck of the prill truck. JF - Journal of Occupational and Environmental Hygiene AU - Torma-Krajewski, Janet AU - Wiehagen, William AU - Etcheverry, Ann AU - Turin, Fred AU - Unger, Richard AD - Pittsburgh Research Laboratory, National Institute of Occupational Safety and Health (NIOSH), Arvada, Colorado Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - Perception KW - Risk factors KW - Temperature KW - Trucks KW - Coal KW - Mining KW - Occupational exposure KW - posture KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899140576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=ErgonomicsUsing+Ergonomics+to+Enhance+Safe+Production+at+a+Surface+Coal+Mine+--+A+Case+Study+with+Powder+Crews&rft.au=Torma-Krajewski%2C+Janet%3BWiehagen%2C+William%3BEtcheverry%2C+Ann%3BTurin%2C+Fred%3BUnger%2C+Richard&rft.aulast=Torma-Krajewski&rft.aufirst=Janet&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903146636 L2 - http://www.informaworld.com/smpp/content~db=all~content=a914046606~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Injuries; Perception; Risk factors; Temperature; Trucks; Mining; Coal; Occupational exposure; posture DO - http://dx.doi.org/10.1080/15459620903146636 ER - TY - JOUR T1 - Short-Term Monitoring of Formaldehyde: Comparison of Two Direct-Reading Instruments to a Laboratory-Based Method AN - 888104856; 15026936 AB - Airborne formaldehyde concentrations can be measured using several different techniques, including laboratory-based methods and direct-reading instruments. Two commercially available direct-reading instruments, an RKI Instruments Model FP-30 and a PPM Technology Formaldemeter htV, were compared with National Institute for Occupational Safety and Health Method 2016 in different test environments to determine if these direct-reading instruments can provide comparable results. The methods yielded the following mean concentrations for 47 samples: NIOSH Method 201,0.37 ppm; FP-3,0.29 ppm; and htV, 0.34 ppm. Results from both of the direct-reading instruments were correlated with the laboratory-based method (R2 = 0.78 for FP-30, and 0.902 for htV). Comparison of the means of the three methods showed that on average the FP-30 instrument (p < 0.001) differed statistically from NIOSH Method 2016, whereas the htV (p = 0.15) was not statistically different from the NIOSH method. Sensitivity and specificity tests demonstrated that the FP-30 had sensitivity above 60% to detect formaldehyde concentrations at all the cutoff levels tested, whereas the htV appeared to have greater sensitivity above 88% for the levels evaluated. JF - Journal of Occupational and Environmental Hygiene AU - Hirst, Deborah V L AU - Gressel, Michael G AU - Flanders, W Dana AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Sensitivity KW - Occupational safety KW - Formaldehyde KW - Monitoring instruments KW - Technology KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888104856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Short-Term+Monitoring+of+Formaldehyde%3A+Comparison+of+Two+Direct-Reading+Instruments+to+a+Laboratory-Based+Method&rft.au=Hirst%2C+Deborah+V+L%3BGressel%2C+Michael+G%3BFlanders%2C+W+Dana&rft.aulast=Hirst&rft.aufirst=Deborah+V&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2011.578499 L2 - http://www.informaworld.com/smpp/content~db=all~content=a937348346~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Sensitivity; Occupational safety; Formaldehyde; Technology; Monitoring instruments DO - http://dx.doi.org/10.1080/15459624.2011.578499 ER - TY - JOUR T1 - Comparison of Free Radical Generation by Pre- and Post-Sintered Cemented Carbide Particles AN - 888104712; 15026792 AB - Rapid generation of reactive oxygen species (ROS) may occur in response to cellular contact with metal particles. Generation of ROS by cobalt and/or tungsten carbide is implicated in causing hard metal lung disease (HMD) and allergic contact dermatitis (ACD). In this study, ROS generation and particle properties that influence radical generation were assessed for three sizes of tungsten, tungsten carbide, cobalt, admixture (tungsten carbide and cobalt powders), spray dryer, and post-sintered chamfer grinder powders using chemical (H2O2 plus phosphate buffered saline, artificial lung surfactant, or artificial sweat) and cellular (RAW 264.7 mouse peritoneal monocytes plus artificial lung surfactant) reaction systems. For a given material, on a mass basis, hydroxyl (.OH) generation generally increased as particle size decreased; however, on a surface area basis, radical generation levels were more, but not completely, similar. Chamfer grinder powder, polycrystalline aggregates of tungsten carbide in a metallic cobalt matrix, generated the highest levels of .OH radicals (p < 0.05). Radical generation was not dependent on the masses of metals, rather, it involved surface-chemistry-mediated reactions that were limited to a biologically active fraction of the total available surface area of each material. Improved understanding of particle surface chemistry elucidated the importance of biologically active surface area in generation of ROS by particle mixtures. JF - Journal of Occupational and Environmental Hygiene AU - Stefaniak, Aleksandr B AU - Harvey, Christopher J AU - Bukowski, Valerie C AU - Leonard, Stephen S AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts KW - Metals KW - Lung KW - Cobalt KW - surface chemistry KW - Sprays KW - Particulates KW - Surfactants KW - Tungsten KW - surface area KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888104712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Comparison+of+Free+Radical+Generation+by+Pre-+and+Post-Sintered+Cemented+Carbide+Particles&rft.au=Stefaniak%2C+Aleksandr+B%3BHarvey%2C+Christopher+J%3BBukowski%2C+Valerie+C%3BLeonard%2C+Stephen+S&rft.aulast=Stefaniak&rft.aufirst=Aleksandr&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903349073 L2 - http://www.informaworld.com/smpp/content~db=all~content=a916729414~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Metals; Lung; surface chemistry; Cobalt; Sprays; Particulates; Surfactants; surface area; Tungsten DO - http://dx.doi.org/10.1080/15459620903349073 ER - TY - JOUR T1 - Comparison of Air Sampling Methods for Aerosolized Spores of B. anthracis Sterne AN - 888102532; 15026915 AB - Bacillus anthracis Sterne spores were aerosolized within a chamber at concentrations ranging from 1t103 to 1.7t104 spores per cubic meter of air (particles (p)/m3) to compare three different sampling methods: Andersen samplers, gelatin filters, and polytetrafluoroethylene (PTFE) membrane filters. Three samples of each type were collected during each of 19 chamber runs. Chamber concentration was determined by an aerodynamic particle sizer (APS) for the size range of 1.114-1.596 Delta *mm. Runs were categorized (low, medium, and high) based on tertiles of the APS estimated air concentrations. Measured air concentrations and recovery efficiency [ratio of the measured (colony forming units (CFU)/m3) to the APS estimated (particles/m3) air concentrations] for the sampling methods were compared using mixed-effects regression models. Limits of detection for each method were estimated based on estimated recovery efficiencies. Mean APS estimated air concentrations were 1600 particles/m3, 4100 particles/m3, and 9100 particles/m3 at the low, medium, and high tertiles, respectively; coefficient of variation (CV) ranged from 25 to 40%. Statistically significant differences were not observed among the three sampling methods. At the high and medium tertiles, estimated correlations of measured air concentration (CFU/m3) among samples collected from the same run of the same type were high (0.73 to 0.93). Among samples collected from the same run but of different types, correlations were moderate to high (0.45 to 0.85); however, correlations were somewhat lower at the low tertile (-0.31 to 0.75). Estimated mean recovery efficiencies ranged from 0.22 to 0.25 CFU/particle with total CVs of approximately 84 to 97%. Estimated detection limits ranged from 35 to 39 particles/m3. These results will enable investigators to conduct environmental sampling, quantify contamination levels, and conduct risk assessments of B. anthracis. JF - Journal of Occupational and Environmental Hygiene AU - Estill, Cheryl Fairfield AU - Baron, Paul A AU - Beard, Jeremy K AU - Hein, Misty J AU - Larsen, Lloyd D AU - Deye, Gregory J AU - Rose, Laura AU - Hodges, Lisa AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Meteorological & Geoastrophysical Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Environmental monitoring KW - Membranes KW - Aerosol samplers KW - Regression models KW - Correlations KW - Statistical analysis KW - Particulates KW - Bacillus anthracis KW - Filters KW - Aerodynamics KW - Air sampling KW - Sampling methods KW - R2 23080:Industrial and labor KW - M2 551.510.42:Air Pollution (551.510.42) KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888102532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Comparison+of+Air+Sampling+Methods+for+Aerosolized+Spores+of+B.+anthracis+Sterne&rft.au=Estill%2C+Cheryl+Fairfield%3BBaron%2C+Paul+A%3BBeard%2C+Jeremy+K%3BHein%2C+Misty+J%3BLarsen%2C+Lloyd+D%3BDeye%2C+Gregory+J%3BRose%2C+Laura%3BHodges%2C+Lisa&rft.aulast=Estill&rft.aufirst=Cheryl&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2011.556981 L2 - http://www.informaworld.com/smpp/content~db=all~content=a933888042~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Regression models; Aerosol samplers; Statistical analysis; Correlations; Environmental monitoring; Risk assessment; Filters; Membranes; Aerodynamics; Air sampling; Particulates; Sampling methods; Bacillus anthracis DO - http://dx.doi.org/10.1080/15459624.2011.556981 ER - TY - JOUR T1 - Analytical Performance CriteriaStandardized Surface Dust Sampling Methods for Metals, with Emphasis on Beryllium AN - 888101995; 15026775 JF - Journal of Occupational and Environmental Hygiene AU - Ashley, Kevin AU - Braybrooke, Geoffrey AU - Jahn, Steven D AU - Brisson, Michael J AU - White, Kenneth T AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Beryllium KW - Dust KW - Metals KW - Sampling methods KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888101995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Analytical+Performance+CriteriaStandardized+Surface+Dust+Sampling+Methods+for+Metals%2C+with+Emphasis+on+Beryllium&rft.au=Ashley%2C+Kevin%3BBraybrooke%2C+Geoffrey%3BJahn%2C+Steven+D%3BBrisson%2C+Michael+J%3BWhite%2C+Kenneth+T&rft.aulast=Ashley&rft.aufirst=Kevin&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903022597 L2 - http://www.informaworld.com/smpp/content~db=all~content=a916670748~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Metals; Beryllium; Dust; Sampling methods DO - http://dx.doi.org/10.1080/15459620903022597 ER - TY - JOUR T1 - Deepwater Horizon Response Workers Exposure Assessment at the Source: MC252 Well No. 1 AN - 888100355; 15026933 JF - Journal of Occupational and Environmental Hygiene AU - Ahrenholz, Steven H AU - Sylvain, David C AD - U.S. Department of Health and Human Services; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health; Division of Surveillance, Hazard Evaluations, and Field Studies; Hazard Evaluation and Technical Assistance Branch, Cincinnati, Ohio Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888100355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Deepwater+Horizon+Response+Workers+Exposure+Assessment+at+the+Source%3A+MC252+Well+No.+1&rft.au=Ahrenholz%2C+Steven+H%3BSylvain%2C+David+C&rft.aulast=Ahrenholz&rft.aufirst=Steven&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2011.575011 L2 - http://www.informaworld.com/smpp/content~db=all~content=a937803520~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Occupational exposure DO - http://dx.doi.org/10.1080/15459624.2011.575011 ER - TY - JOUR T1 - Evaluation of Nano- and Submicron Particle Penetration through Ten Nonwoven Fabrics Using a Wind-Driven Approach AN - 888100319; 15026895 AB - Existing face mask and respirator test methods draw particles through materials under vacuum to measure particle penetration. However, these filtration-based methods may not simulate conditions under which protective clothing operates in the workplace, where airborne particles are primarily driven by wind and other factors instead of being limited to a downstream vacuum. This study was focused on the design and characterization of a method simulating typical wind-driven conditions for evaluating the performance of materials used in the construction of protective clothing. Ten nonwoven fabrics were selected, and physical properties including fiber diameter, fabric thickness, air permeability, porosity, pore volume, and pore size were determined. Each fabric was sealed flat across the wide opening of a cone-shaped penetration cell that was then housed in a recirculation aerosol wind tunnel. The flow rate naturally driven by wind through the fabric was measured, and the sampling flow rate of the Scanning Mobility Particle Sizer used to measure the downstream particle size distribution and concentrations was then adjusted to minimize filtration effects. Particle penetration levels were measured under different face velocities by the wind-driven method and compared with a filtration-based method using the TSI 3160 automated filter tester. The experimental results show that particle penetration increased with increasing face velocity, and penetration also increased with increasing particle size up to about 300 to 500 nm. Penetrations measured by the wind-driven method were lower than those obtained with the filtration method for most of the fabrics selected, and the relative penetration performances of the fabrics were very different due to the vastly different pore structures. JF - Journal of Occupational and Environmental Hygiene AU - Gao, Pengfei AU - Jaques, Peter A AU - Hsiao, Ta-Chih AU - Shepherd, Angie AU - Eimer, Benjamin C AU - Yang, Mengshi AU - Miller, Adam AU - Gupta, Bhupender AU - Shaffer, Ronald AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Particle size KW - Filtration KW - Protective clothing KW - Aerosols KW - downstream KW - Wind tunnels KW - Velocity KW - Particulates KW - Flow rates KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888100319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Evaluation+of+Nano-+and+Submicron+Particle+Penetration+through+Ten+Nonwoven+Fabrics+Using+a+Wind-Driven+Approach&rft.au=Gao%2C+Pengfei%3BJaques%2C+Peter+A%3BHsiao%2C+Ta-Chih%3BShepherd%2C+Angie%3BEimer%2C+Benjamin+C%3BYang%2C+Mengshi%3BMiller%2C+Adam%3BGupta%2C+Bhupender%3BShaffer%2C+Ronald&rft.aulast=Gao&rft.aufirst=Pengfei&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2010.515554 L2 - http://www.informaworld.com/smpp/content~db=all~content=a930952290~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Particle size; Aerosols; Protective clothing; Filtration; Wind tunnels; downstream; Velocity; Particulates; Flow rates DO - http://dx.doi.org/10.1080/15459624.2010.515554 ER - TY - JOUR T1 - Identification and Measurement of Diacetyl Substitutes in Dry Bakery Mix Production AN - 888095036; 15026905 AB - In 2008, a company using multiple buttermilk flavorings in the production of dry bakery mixes replaced one liquid flavoring containing 15-20% diacetyl with a proprietary substitute meant to lower occupational risk for diacetyl-related bronchiolitis obliterans. Subsequently, the National Institute for Occupational Safety and Health (NIOSH) evaluated buttermilk flavoring-related exposures at this company's facility, with a focus on measuring ketones by several methods. Volatile organic compounds (VOCs) were evaluated in the headspaces of six bulk flavorings samples, including the substitute buttermilk flavoring. Ketones were evaluated in workplace air via area and personal samples collected during batch preparation of the substitute buttermilk flavoring and production of a bakery mix containing the same flavoring. Air samples were evaluated using five different methods: NIOSH 2549, Modified OSHA PV2118, OSHA 1013, NIOSH Draft Procedure SMP2, and evacuated canisters. Of five buttermilk flavorings from five different flavorings manufacturers, diacetyl was present in four, including the substitute flavoring; acetoin in two; 2,3-pentanedione in four; 2,3-hexanedione in one; and 2,3-heptanedione in three. Among material safety data sheets (MSDS) for four flavorings, only one listed a hazardous ingredient, which was acetoin. The predominant flavoring ingredient identified in the headspace of the substitute flavoring was 2,3-pentanedione; all other chemicals noted above were also present. Diacetyl and 2,3-pentanedione were measured in workplace air via evacuated canisters. In one area and one personal air sample, 2,3-pentanedione was measured by OSHA Method 1013 at concentrations of 78 and 91 ppb, respectively. Without their or the employer's knowledge, workers who used buttermilk flavorings were exposed to substitute ketones from many flavorings manufacturers. Because 2,3-pentanedione, 2,3-hexanedione, and 2,3-heptanedione all share the same functional a-diketone group as diacetyl, these compounds also may share diacetyl's mechanism of toxicity. Until more is known about 2,3-pentanedione and other a-diketone compounds, they should not be assumed to be safe. Companies using artificial buttermilk flavorings should use a precautionary approach that assumes these flavorings pose a health risk and limit exposures through engineering and administrative controls and use of personal protective equipment. JF - Journal of Occupational and Environmental Hygiene AU - Day, Gregory AU - Lebouf, Ryan AU - Grote, Ardith AU - Pendergrass, Stephanie AU - Cummings, Kristin AU - Kreiss, Kathleen AU - Kullman, Greg AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Risk Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Risk assessment KW - Federal regulations KW - Ketones KW - safety engineering KW - Air sampling KW - safety regulations KW - Toxicity KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888095036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Identification+and+Measurement+of+Diacetyl+Substitutes+in+Dry+Bakery+Mix+Production&rft.au=Day%2C+Gregory%3BLebouf%2C+Ryan%3BGrote%2C+Ardith%3BPendergrass%2C+Stephanie%3BCummings%2C+Kristin%3BKreiss%2C+Kathleen%3BKullman%2C+Greg&rft.aulast=Day&rft.aufirst=Gregory&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2011.547148 L2 - http://www.informaworld.com/smpp/content~db=all~content=a932570474~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Risk assessment; Chemicals; Federal regulations; safety engineering; Ketones; Air sampling; safety regulations; Toxicity; Occupational exposure DO - http://dx.doi.org/10.1080/15459624.2011.547148 ER - TY - JOUR T1 - Nanoparticle Emission Assessment Technique (NEAT) for the Identification and Measurement of Potential Inhalation Exposure to Engineered Nanomaterials--Part B: Results from 12 Field Studies AN - 888095015; 15026811 AB - The National Institute for Occupational Safety and Health (NIOSH) conducted field studies at 12 sites using the Nanoparticle Emission Assessment Technique (NEAT) to characterize emissions during processes where engineered nanomaterials were produced or used. A description of the NEAT appears in Part A of this issue. Field studies were conducted in research and development laboratories, pilot plants, and manufacturing facilities handling carbon nanotubes (single-walled and multi-walled), carbon nanofibers, fullerenes, carbon nanopearls, metal oxides, electrospun nylon, and quantum dots. The results demonstrated that the NEAT was useful in evaluating emissions and that readily available engineering controls can be applied to minimize nanomaterial emissions. JF - Journal of Occupational and Environmental Hygiene AU - Methner, M AU - Hodson, L AU - Dames, A AU - Geraci, C AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio Y1 - 2009///0, PY - 2009 DA - 0, 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Nylon KW - Manufacturing industry KW - Metals KW - Occupational safety KW - Carbon KW - Fullerenes KW - Quantum dots KW - Emissions KW - nanotubes KW - oxides KW - nanoparticles KW - Research programs KW - nanotechnology KW - Environmental hygiene KW - X 24360:Metals KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888095015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Nanoparticle+Emission+Assessment+Technique+%28NEAT%29+for+the+Identification+and+Measurement+of+Potential+Inhalation+Exposure+to+Engineered+Nanomaterials--Part+B%3A+Results+from+12+Field+Studies&rft.au=Methner%2C+M%3BHodson%2C+L%3BDames%2C+A%3BGeraci%2C+C&rft.aulast=Methner&rft.aufirst=M&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903508066 L2 - http://www.informaworld.com/smpp/content~db=all~content=a918375811~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Nylon; Inhalation; Metals; Carbon; Fullerenes; Quantum dots; oxides; nanotubes; nanoparticles; Environmental hygiene; nanotechnology; Manufacturing industry; Occupational safety; Emissions; Research programs DO - http://dx.doi.org/10.1080/15459620903508066 ER - TY - JOUR T1 - Nanoparticle Emission Assessment Technique (NEAT) for the Identification and Measurement of Potential Inhalation Exposure to Engineered Nanomaterials -- Part A AN - 888095002; 15026806 AB - There are currently no exposure limits specific to engineered nanomaterial nor any national or international consensus standards on measurement techniques for nanomaterials in the workplace. However, facilities engaged in the production and use of engineered nanomaterials have expressed an interest in learning whether the potential for worker exposure exists. To assist with answering this question, the National Institute for Occupational Safety and Health established a nanotechnology field research team whose primary goal was to visit facilities and evaluate the potential for release of nanomaterials and worker exposure. The team identified numerous techniques to measure airborne nanomaterials with respect to particle size, mass, surface area, number concentration, and composition. However, some of these techniques lack specificity and field portability and are difficult to use and expensive when applied to routine exposure assessment. This article describes the nanoparticle emission assessment technique (NEAT) that uses a combination of measurement techniques and instruments to assess potential inhalation exposures in facilities that handle or produce engineered nanomaterials. The NEAT utilizes portable direct-reading instrumentation supplemented by a pair of filter-based air samples (source-specific and personal breathing zone). The use of the filter-based samples are crucial for identification purposes because particle counters are generally insensitive to particle source or composition and make it difficult to differentiate between incidental and process-related nanomaterials using number concentration alone. Results from using the NEAT at 12 facilities are presented in the companion article (Part B) in this issue. JF - Journal of Occupational and Environmental Hygiene AU - Methner, M AU - Hodson, L AU - Geraci, C AD - National Institute for Occupational Safety and Health (NIOSH), Nanotechnology Research Center, Cincinnati, Ohio Y1 - 2009///0, PY - 2009 DA - 0, 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Particle size KW - Learning KW - Surface area KW - Respiration KW - Particulates KW - Emissions KW - Air sampling KW - particle counters KW - nanoparticles KW - Occupational exposure KW - International standardization KW - nanotechnology KW - Environmental hygiene KW - H 1000:Occupational Safety and Health KW - X 24300:Methods KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888095002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Nanoparticle+Emission+Assessment+Technique+%28NEAT%29+for+the+Identification+and+Measurement+of+Potential+Inhalation+Exposure+to+Engineered+Nanomaterials+--+Part+A&rft.au=Methner%2C+M%3BHodson%2C+L%3BGeraci%2C+C&rft.aulast=Methner&rft.aufirst=M&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903476355 L2 - http://www.informaworld.com/smpp/content~db=all~content=a917889791~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Particle size; Inhalation; Learning; Respiration; Surface area; nanoparticles; Occupational exposure; Environmental hygiene; nanotechnology; Air sampling; Emissions; Particulates; particle counters; International standardization DO - http://dx.doi.org/10.1080/15459620903476355 ER - TY - JOUR T1 - Embracing a Clean-Energy Future AN - 754080368; 2010-597134 AB - The former governor of Kansas describes how her state is greening. The Blue Green Alliance has estimated that in a renewable-energy economy, Kansas stands to gain more than 11,000 jobs and almost $2 billion in new economic investments. Adapted from the source document. JF - New Solutions: A Journal of Environmental and Occupational Health Policy AU - Sebelius, Kathleen AD - U.S. Department of Health and Human Services Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 147 EP - 148 PB - Baywood Publishing, Amityville NY VL - 19 IS - 2 SN - 1048-2911, 1048-2911 KW - Energy resources and policy - Energy policy KW - Environment and environmental policy - Ecology and environmental policy KW - Energy resources and policy - Renewable energy sources KW - Economic conditions and policy - Economic policy, planning, and development KW - Environment KW - Kansas KW - Energy policy KW - Economic development KW - Renewable energy sources KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754080368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+Solutions%3A+A+Journal+of+Environmental+and+Occupational+Health+Policy&rft.atitle=Embracing+a+Clean-Energy+Future&rft.au=Sebelius%2C+Kathleen&rft.aulast=Sebelius&rft.aufirst=Kathleen&rft.date=2009-01-01&rft.volume=19&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=New+Solutions%3A+A+Journal+of+Environmental+and+Occupational+Health+Policy&rft.issn=10482911&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2010-09-10 N1 - Last updated - 2016-09-28 N1 - CODEN - NESLES N1 - SubjectsTermNotLitGenreText - Energy policy; Environment; Kansas; Renewable energy sources; Economic development ER - TY - JOUR T1 - Occupational Toxicology of Nickel and Nickel Compounds AN - 746080453; 12926380 AB - Nickel and nickel compounds are widely used in industry. The high consumption of nickel products inevitably leads to occupational and environmental pollution. In occupational settings, exposure to nickel and nickel compounds occurs primarily during nickel refining, electroplating, and welding. The most common airborne exposures to nickel in the workplace are to insoluble nickel species, such as metallic nickel, nickel sulfide, and nickel oxides from dusts and fumes. The chemical and physical properties of nickel and nickel compounds strongly influence their bioavailability and toxicity. The lung and the skin are the principal target organs upon occupational exposure. inhalation exposure is a primary route for nickel-induced toxicity in the workplace. The most important adverse health effects due to occupational exposure to nickel and its compounds are skin allergies, lung fibrosis, and lung cancer. The exact mechanisms of nickel-induced carcinogenesis are not clear. This review summarizes the current knowledge on occupational toxicology of nickel and its compounds. The subtopics include: chemical and physical properties, uses, occupational exposures, occupational exposure limits, toxicokinetics, biological monitoring, acute toxicity, chronic toxicity, genotoxicity, reproductive toxicity, carcinogenicity, molecular mechanisms of carcinogenesis, and gaps in knowledge. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Zhao, Jinshun AU - Shi, Xianglin AU - Castranova, Vincent AU - Ding, Min AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 Y1 - 2009 PY - 2009 DA - 2009 SP - 177 EP - 208 PB - Begell House Inc., 79 Madison Avenue, Suite 1201 New York NY 10016-7892 USA VL - 28 IS - 3 SN - 0731-8898, 0731-8898 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Inhalation KW - acute toxicity KW - Molecular modelling KW - Fibrosis KW - Nickel KW - Acute toxicity KW - Allergies KW - Dust KW - Bioavailability KW - Hypersensitivity KW - Carcinogenicity KW - Chronic toxicity KW - Metal finishing industry KW - Welding KW - oxides KW - Nickel compounds KW - Toxicology KW - Pollution KW - Occupational exposure KW - Lung cancer KW - Skin KW - Fumes KW - Sulfides KW - Genotoxicity KW - Toxicity KW - Cancer KW - Sulfide KW - Reviews KW - Carcinogenesis KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746080453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Occupational+Toxicology+of+Nickel+and+Nickel+Compounds&rft.au=Zhao%2C+Jinshun%3BShi%2C+Xianglin%3BCastranova%2C+Vincent%3BDing%2C+Min&rft.aulast=Zhao&rft.aufirst=Jinshun&rft.date=2009-01-01&rft.volume=28&rft.issue=3&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Inhalation; Molecular modelling; Fumes; Skin; Fibrosis; Nickel; Genotoxicity; Acute toxicity; Dust; Sulfide; Bioavailability; Hypersensitivity; Chronic toxicity; Carcinogenesis; oxides; Welding; Occupational exposure; Pollution; Lung cancer; acute toxicity; Sulfides; Toxicity; Allergies; Cancer; Carcinogenicity; Reviews; Metal finishing industry; Nickel compounds; Toxicology ER - TY - JOUR T1 - That Horse Bit Me: Zoonotic Infections of Equines to Consider after Exposure Through the Bite or the Oral/Nasal Secretions AN - 744624520; 13054579 AB - Millions of individuals are in contact with horses through occupational or recreational activities. Injuries from horses are responsible for over 100,000 emergency room visits each year in the United States. Although various types of traumatic injuries related to direct contact with horses are well described, roughly 3% to 4.5% of all reported injuries are due to bites by equines. The immediate injuries are commonly either blunt or penetrating trauma to local tissue; however, the bite exposure may also transmit a microbial agent of equine origin that can lead to a zoonotic infection. In almost all jurisdictions in the United States, animal bites are considered public health events and should be reported to the local health departments. Many animals can harbor many unusual zoonotic pathogens that both the individual health provider and public health officials much consider as they can adversely impact both the patient and the community health. This review focuses on those zoonoses that have been reported in the literature, including those that may in theory be transmitted from equine to human by direct inoculation or exposure to oral/nasal secretions from horses and other equine species. JF - Journal of Agromedicine AU - Langley, R AU - Morris, T AD - North Carolina Department of Health and Human Services, Occupational and Environmental Epidemiology Branch, Raleign, North Carolina, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 370 EP - 381 VL - 14 IS - 3 SN - 1059-924X, 1059-924X KW - Health & Safety Science Abstracts; Risk Abstracts KW - horses KW - Injuries KW - Pathogens KW - jurisdiction KW - Public health KW - USA KW - Recreation areas KW - Reviews KW - bites KW - infection KW - zoonoses KW - emergency medical services KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744624520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=That+Horse+Bit+Me%3A+Zoonotic+Infections+of+Equines+to+Consider+after+Exposure+Through+the+Bite+or+the+Oral%2FNasal+Secretions&rft.au=Langley%2C+R%3BMorris%2C+T&rft.aulast=Langley&rft.aufirst=R&rft.date=2009-01-01&rft.volume=14&rft.issue=3&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F10599240903058087 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Injuries; horses; Recreation areas; Reviews; bites; infection; zoonoses; jurisdiction; Pathogens; emergency medical services; Public health; USA DO - http://dx.doi.org/10.1080/10599240903058087 ER - TY - JOUR T1 - Windblown Lead Carbonate as the Main Source of Lead in Blood of Children from a Seaside Community: An Example of Local Birds as "Canaries in the Mine" AN - 743565107; 201004-31-0316648 (CE); 12129457 (EN) AB - BACKGROUND: In late 2006, the seaside community in Esperance, Western Australia, was alerted to thousands of native bird species dying. The source of the lead was thought to derive from the handling of Pb carbonate concentrate from the Magellan mine through the port of Esperance, begun in July 2005. Concern was expressed for the impact of this process on the community. OBJECTIVE: This study was designed to evaluate the source of Pb in blood of a random sample of the community using Pb isotope ratios. METHODS: The cohort comprised 49 children (48 5 years of age) along with 18 adults ( 20 years of age) with a bias toward higher blood lead (PbB) values to facilitate source identification. RESULTS: Mean PbB level of the children was 7.5 microg/dL (range, 1.5-25.7 microg/dL; n = 49; geometric mean, 6.6 microg/dL), with four children whose PbB was 12 microg/dL. The isotopic data for blood samples lay around two distinct arrays. The blood of all children analyzed for Pb isotopes contained a contribution of Pb from the Magellan mine, which for young children ranged from 27% up to 93% (mean, 64%; median, 71%). Subtraction of the ore component gave a mean background PbB of 2.3 mug/dL. Several children whose PbB was 9 microg/dL and most of the older subjects have complex sources of Pb. CONCLUSIONS: The death of the birds acted as a sentinel event; otherwise, the exposure of the community, arising from such a toxic form of Pb, could have been tragic. Isotopic data and mineralogic and particle size analyses indicate that, apart from the recognized pathway of Pb exposure by hand-to-mouth activity in children, the inhalation pathway could have been a significant contributor to PbB for some of the very young children and in some parents. JF - Environmental Health Perspectives AU - Gulson, Brian AU - Korsch, Michael AU - Matisons, Martin AU - Douglas, Charles AU - Gillam, Lindsay AU - McLaughlin, Virginia PY - 2009 SP - 148 EP - 154 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Children KW - Lead (metal) KW - Communities KW - Blood KW - Birds KW - Health KW - Carbonates KW - Pathways KW - Age KW - Mines KW - Arrays KW - Materials handling KW - Western Australia KW - Adults KW - Toxic KW - Parents KW - Isotope ratios KW - Bias KW - Isotopes KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743565107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Windblown+Lead+Carbonate+as+the+Main+Source+of+Lead+in+Blood+of+Children+from+a+Seaside+Community%3A+An+Example+of+Local+Birds+as+%22Canaries+in+the+Mine%22&rft.au=Gulson%2C+Brian%3BKorsch%2C+Michael%3BMatisons%2C+Martin%3BDouglas%2C+Charles%3BGillam%2C+Lindsay%3BMcLaughlin%2C+Virginia&rft.aulast=Gulson&rft.aufirst=Brian&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Traffic-Related Air Pollution and Perinatal Mortality: A Case-Control Study AN - 743540691; 201004-31-0316651 (CE); 12129460 (EN) AB - BACKGROUND: Ambient levels of air pollution may affect the health of children, as indicated by studies of infant and perinatal mortality. Scientific evidence has also correlated low birth weight and preterm birth, which are important determinants of perinatal death, with air pollution. However, most of these studies used ambient concentrations measured at monitoring sites, which may not consider differential exposure to pollutants found at elevated concentrations near heavy-traffic roadways. OBJECTIVES: Our goal was to examine the association between traffic-related pollution and perinatal mortality. METHODS: We used the information collected for a case-control study conducted in 14 districts in the City of Sao Paulo, Brazil, regarding risk factors for perinatal deaths. We geocoded the residential addresses of cases (fetal and early neonatal deaths) and controls (children who survived the 28th day of life) and calculated a distance-weighted traffic density (DWTD) measure considering all roads contained in a buffer surrounding these homes. RESULTS: Logistic regression revealed a gradient of increasing risk of early neonatal death with higher exposure to traffic-related air pollution. Mothers exposed to the highest quartile of the DWTD compared with those less exposed exhibited approximately 50% increased risk (adjusted odds ratio = 1.47; 95% confidence interval, 0.67-3.19). Associations for fetal mortality were less consistent. CONCLUSIONS: These results suggest that motor vehicle exhaust exposures may be a risk factor for perinatal mortality. JF - Environmental Health Perspectives AU - de Medeiros, Andrea Paula Peneluppi AU - Gouveia, Nelson AU - Machado, Reinaldo Paul Perez AU - de Souza, Miriam Regina AU - Alencar, Gizelton Pereira AU - Novaes, Hillegonda Maria Dutilh AU - de Almeida, Marcia Furquim PY - 2009 SP - 127 EP - 132 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Air pollution KW - Mortality KW - Risk KW - Death KW - Health KW - Children KW - Birth KW - Exposure KW - Density KW - Infants KW - Nova KW - Regression KW - Traffic flow KW - Correlation KW - Determinants KW - Motor vehicles KW - Roads KW - Traffic engineering KW - Mathematical analysis KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743540691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Traffic-Related+Air+Pollution+and+Perinatal+Mortality%3A+A+Case-Control+Study&rft.au=de+Medeiros%2C+Andrea+Paula+Peneluppi%3BGouveia%2C+Nelson%3BMachado%2C+Reinaldo+Paul+Perez%3Bde+Souza%2C+Miriam+Regina%3BAlencar%2C+Gizelton+Pereira%3BNovaes%2C+Hillegonda+Maria+Dutilh%3Bde+Almeida%2C+Marcia+Furquim&rft.aulast=de+Medeiros&rft.aufirst=Andrea+Paula&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - The 2006 California Heat Wave: Impacts on Hospitalizations and Emergency Department Visits AN - 743497053; 201004-31-0316660 (CE); 12129469 (EN) AB - BACKGROUND: Climate models project that heat waves will increase in frequency and severity. Despite many studies of mortality from heat waves, few studies have examined morbidity. OBJECTIVES: In this study we investigated whether any age or race/ethnicity groups experienced increased hospitalizations and emergency department (ED) visits overall or for selected illnesses during the 2006 California heat wave. METHODS: We aggregated county-level hospitalizations and ED visits for all causes and for 10 cause groups into six geographic regions of California. We calculated excess morbidity and rate ratios (RRs) during the heat wave (15 July to 1 August 2006) and compared these data with those of a reference period (8-14 July and 12-22 August 2006). RESULTS: During the heat wave, 16,166 excess ED visits and 1,182 excess hospitalizations occurred statewide. ED visits for heat-related causes increased across the state [RR = 6.30; 95% confidence interval (CI), 5.67-7.01], especially in the Central Coast region, which includes San Francisco. Children (0-4 years of age) and the elderly ( or = 65 years of age) were at greatest risk. ED visits also showed significant increases for acute renal failure, cardiovascular diseases, diabetes, electrolyte imbalance, and nephritis. We observed significantly elevated RRs for hospitalizations for heat-related illnesses (RR = 10.15; 95% CI, 7.79-13.43), acute renal failure, electrolyte imbalance, and nephritis. CONCLUSIONS: The 2006 California heat wave had a substantial effect on morbidity, including regions with relatively modest temperatures. This suggests that population acclimatization and adaptive capacity influenced risk. By better understanding these impacts and population vulnerabilities, local communities can improve heat wave preparedness to cope with a globally warming future. JF - Environmental Health Perspectives AU - Knowlton, Kim AU - Rotkin-Ellman, Miriam AU - King, Galatea AU - Margolis, Helene G AU - Smith, Daniel AU - Solomon, Gina AU - Trent, Roger AU - English, Paul PY - 2009 SP - 61 EP - 67 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Age KW - Failure KW - Emergencies KW - Risk KW - Health KW - Mathematical models KW - Illnesses KW - Electrolytes KW - Nephritis KW - Emergency medical services KW - Diseases KW - Helene KW - Children KW - Mortality KW - Galatea KW - Race KW - Confidence intervals KW - Elevated KW - Communities KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743497053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+2006+California+Heat+Wave%3A+Impacts+on+Hospitalizations+and+Emergency+Department+Visits&rft.au=Knowlton%2C+Kim%3BRotkin-Ellman%2C+Miriam%3BKing%2C+Galatea%3BMargolis%2C+Helene+G%3BSmith%2C+Daniel%3BSolomon%2C+Gina%3BTrent%2C+Roger%3BEnglish%2C+Paul&rft.aulast=Knowlton&rft.aufirst=Kim&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Associations between PMsub 2.5 and Heart Rate Variability Are Modified by Particle Composition and Beta-Blocker Use in Patients with Coronary Heart Disease AN - 743474447; 201004-31-0316654 (CE); 12129463 (EN) AB - BACKGROUND: It has been hypothesized that ambient particulate air pollution is able to modify the autonomic nervous control of the heart, measured as heart rate variability (HRV). Previously we reported heterogeneous associations between particulate matter with aerodynamic diameter 2.5 microm (PM2.5) and HRV across three study centers. OBJECTIVES: We evaluated whether exposure misclassification, effect modification by medication, or differences in particle composition could explain the inconsistencies. METHODS: Subjects with coronary heart disease visited clinics biweekly in Amsterdam, the Netherlands; Erfurt, Germany; and Helsinki, Finland for 6-8 months. The standard deviation (SD) of NN intervals on an electrocardiogram (ECG; SDNN) and high frequency (HF) power of HRV was measured with ambulatory ECG during paced breathing. Outdoor levels of PM2.5 were measured at a central site. In Amsterdam and Helsinki, indoor and personal PM2.5 were measured during the 24 hr preceding the clinic visit. PM2.5 was apportioned between sources using principal component analyses. We analyzed associations of indoor/personal PM2.5, elements of PM2.5, and source-specific PM2.5 with HRV using linear regression. RESULTS: Indoor and personal PM2.5 were not associated with HRV. Increased outdoor PM2.5 was associated with decreased SDNN and HF at lags of 2 and 3 days only among persons not using beta-blocker medication. Traffic-related PM2.5 was associated with decreased SDNN, and long-range transported PM2.5 with decreased SDNN and HF, most strongly among persons not using beta blockers. Indicators for PM2.5 from traffic and long-range transport were also associated with decreased HRV. CONCLUSIONS: Our results suggest that differences in the composition of particles, beta-blocker use, and obesity of study subjects may explain some inconsistencies among previous studies on HRV. JF - Environmental Health Perspectives AU - de Hartog, Jeroen J AU - Lanki, Timo AU - Timonen, Kirsi L AU - Hoek, Gerard AU - Janssen, Nicole A H AU - Ibald-Mulli, Angela AU - Peters, Annette AU - Heinrich, Joachim AU - Tarkiainen, Tuula H AU - van Grieken, Rene AU - van Wijnen, Joop H AU - Brunekreef, Bert AU - Pekkanen, Juha PY - 2009 SP - 105 EP - 111 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Indoor KW - Neural networks KW - Heart diseases KW - Heart rate KW - Health KW - Outdoor KW - Air pollution KW - Beta KW - Regression KW - Patients KW - Principal component analysis KW - Standard deviation KW - Intervals KW - Traffic flow KW - Traffic engineering KW - Indicators KW - Heart KW - Copyrights KW - High frequencies KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743474447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Associations+between+PMsub+2.5+and+Heart+Rate+Variability+Are+Modified+by+Particle+Composition+and+Beta-Blocker+Use+in+Patients+with+Coronary+Heart+Disease&rft.au=de+Hartog%2C+Jeroen+J%3BLanki%2C+Timo%3BTimonen%2C+Kirsi+L%3BHoek%2C+Gerard%3BJanssen%2C+Nicole+A+H%3BIbald-Mulli%2C+Angela%3BPeters%2C+Annette%3BHeinrich%2C+Joachim%3BTarkiainen%2C+Tuula+H%3Bvan+Grieken%2C+Rene%3Bvan+Wijnen%2C+Joop+H%3BBrunekreef%2C+Bert%3BPekkanen%2C+Juha&rft.aulast=de+Hartog&rft.aufirst=Jeroen&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Air Pollution and Childhood Respiratory Allergies in the United States AN - 743423945; 201004-31-0316647 (CE); 12129456 (EN) AB - BACKGROUND: Childhood respiratory allergies, which contribute to missed school days and other activity limitations, have increased in recent years, possibly due to environmental factors. OBJECTIVE: In this study we examined whether air pollutants are associated with childhood respiratory allergies in the United States. METHODS: For the approximately 70,000 children from the 1999-2005 National Health Interview Survey eligible for this study, we assigned between 40,000 and 60,000 ambient pollution monitoring data from the U.S. Environmental Protection Agency, depending on the pollutant. We used monitors within 20 miles of the child's residential block group. We used logistic regression models, fit with methods for complex surveys, to examine the associations between the reporting of respiratory allergy or hay fever and annual average exposure to particulate matter or = 2.5 microm in diameter (PM2.5), PM or = 10 microm in diameter, sulfur dioxide, and nitrogen dioxide and summer exposure to ozone, controlling for demographic and geographic factors. RESULTS: Increased respiratory allergy/hay fever was associated with increased summer O3 levels [adjusted odds ratio (AOR) per 10 ppb = 1.20; 95% confidence interval (CI), 1.15-1.26] and increased PM2.5 (AOR per 10 microg/m3 = 1.23; 95% CI, 1.10-1.38). These associations persisted after stratification by urban-rural status, inclusion of multiple pollutants, and definition of exposures by differing exposure radii. No associations between the other pollutants and the reporting respiratory allergy/hay fever were apparent. CONCLUSIONS: These results provide evidence of adverse health for children living in areas with chronic exposure to higher levels of O3 and PM2.5 compared with children with lower exposures. JF - Environmental Health Perspectives AU - Parker, Jennifer D AU - Akinbami, Lara J AU - Woodruff, Tracey J PY - 2009 SP - 140 EP - 147 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Health KW - Mathematical models KW - Pollutants KW - Hay fever KW - Children KW - Reporting KW - Summer KW - Air pollution KW - Inclusions KW - Nitrogen dioxide KW - Monitors KW - Regression KW - Stratification KW - Confidence intervals KW - Sulfur dioxide KW - Ozone KW - Demographics KW - Copyrights KW - Logistics KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743423945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Air+Pollution+and+Childhood+Respiratory+Allergies+in+the+United+States&rft.au=Parker%2C+Jennifer+D%3BAkinbami%2C+Lara+J%3BWoodruff%2C+Tracey+J&rft.aulast=Parker&rft.aufirst=Jennifer&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Urinary Levoglucosan as a Biomarker of Wood Smoke Exposure: Observations in a Mouse Model and in Children AN - 743421821; 201004-31-0316657 (CE); 12129466 (EN) AB - BACKGROUND: Biomass smoke is an important source of particulate matter (PM), and much remains to be discovered with respect to the human health effects associated with this specific PM source. Exposure to biomass smoke can occur in one of two main categories: short-term exposures consist of periodic, seasonal exposures typified by communities near forest fires or intentional agricultural burning, and long-term exposures are chronic and typified by the use of biomass materials for cooking or heating. Levoglucosan (LG), a sugar anhydride released by combustion of cellulose-containing materials, is an attractive candidate as a biomarker of wood smoke exposure. OBJECTIVES: In the present study, Balb/c mice and children were assessed for LG in urine to determine its feasibility as a biomarker. METHODS: We performed urinary detection of LG by gas chromatography/mass spectrometry after intranasal instillations of LG or concentrated PM (mice) or biomass exposure (mice or humans). RESULTS: After instillation, we recovered most of the LG within the first 4 hr. Experiments using glucose instillation proved the specificity of our system, and instillation of concentrated PM from wood smoke, ambient air, and diesel exhaust supported a connection between wood smoke and LG. In addition, LG was detected in the urine of mice exposed to wood smoke. Finally, a pilot human study proved our ability to detect LG in urine of children. CONCLUSIONS: These results demonstrate that LG in the lungs is detectable in the urine of both mice and humans and that it is a good candidate as a biomarker of exposure to biomass smoke. JF - Environmental Health Perspectives AU - Migliaccio, Christopher T AU - Bergauff, Megan A AU - Palmer, Christopher P AU - Jessop, Forrest AU - Noonan, Curtis W AU - Ward, Tony J PY - 2009 SP - 74 EP - 79 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Smoke KW - Wood KW - Mice KW - Biomass KW - Urine KW - Human KW - Children KW - Health KW - Combustion KW - Heating KW - Cooking KW - Categories KW - Anhydrides KW - Diesel KW - Diesel fuels KW - Mass spectrometry KW - Mathematical models KW - Glucose KW - Communities KW - Article KW - EE 20:Air Pollution: Monitoring, Control & Remediation (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743421821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Urinary+Levoglucosan+as+a+Biomarker+of+Wood+Smoke+Exposure%3A+Observations+in+a+Mouse+Model+and+in+Children&rft.au=Migliaccio%2C+Christopher+T%3BBergauff%2C+Megan+A%3BPalmer%2C+Christopher+P%3BJessop%2C+Forrest%3BNoonan%2C+Curtis+W%3BWard%2C+Tony+J&rft.aulast=Migliaccio&rft.aufirst=Christopher&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval AN - 743420367; 201004-31-0316658 (CE); 12129467 (EN) AB - BACKGROUND: Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance the oxidative effects of lead, we examined whether polymorphisms in iron metabolism genes [hemochromatosis (HFE), transferrin (TF) C2, and heme oxygenase-1 (HMOX-1)] increase susceptibility to the effects of lead on QT interval in 613 community-dwelling older men. METHODS: We used standard 12-lead electrocardiograms, K-shell X-ray fluorescence, and graphite furnace atomic absorption spectrometry to measure QT interval, bone lead, and blood lead levels, respectively. RESULTS: A one-interquartile-range increase in tibia lead level (13 mug/g) was associated with a 11.35-msec [95% confidence interval (CI), 4.05-18.65 msec] and a 6.81-msec (95% CI, 1.67-11.95 msec) increase in the heart-rate-corrected QT interval among persons carrying long HMOX-1 alleles and at least one copy of an HFE variant, respectively, but had no effect in persons with short and middle HMOX-1 alleles and the wild-type HFE genotype. The lengthening of the heart-rate-corrected QT interval with higher tibia lead and blood lead became more pronounced as the total number (0 vs. 1 vs. /=2) of gene variants increased (tibia, p-trend = 0.01; blood, p-trend = 0.04). This synergy seems to be driven by a joint effect between HFE variant and HMOX-1 L alleles. CONCLUSION: We found evidence that gene variants related to iron metabolism increase the impacts of low-level lead exposure on the prolonged QT interval. This is the first such report, so these results should be interpreted cautiously and need to be independently verified. JF - Environmental Health Perspectives AU - Park, Sung Kyun AU - Hu, Howard AU - Wright, Robert O AU - Schwartz, Joel AU - Cheng, Yawen AU - Sparrow, David AU - Vokonas, Pantel S AU - Weisskopf, Marc G PY - 2009 SP - 80 EP - 85 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Intervals KW - Iron KW - Genes KW - Tibia KW - Metabolism KW - Blood KW - Health KW - Reproduction KW - Bones KW - Fluorescence KW - Standards KW - Confidence intervals KW - Men KW - Copyrights KW - Polymorphism KW - Atomic absorption analysis KW - X-rays KW - Parks KW - Depression KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743420367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Iron+Metabolism+Genes%2C+Low-Level+Lead+Exposure%2C+and+QT+Interval&rft.au=Park%2C+Sung+Kyun%3BHu%2C+Howard%3BWright%2C+Robert+O%3BSchwartz%2C+Joel%3BCheng%2C+Yawen%3BSparrow%2C+David%3BVokonas%2C+Pantel+S%3BWeisskopf%2C+Marc+G&rft.aulast=Park&rft.aufirst=Sung&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Intrauterine Exposure to Environmental Pollutants and Body Mass Index during the First 3 Years of Life AN - 743358915; 201004-31-0316650 (CE); 12129459 (EN) AB - OBJECTIVE: We investigated the association between body mass index (BMI) standard deviation score (SDS) and prenatal exposure to hexachlorobenzene, dichlorodiphenyldichloroethylene (DDE), dioxin-like compounds, and polychlorinated biphenyls (PCBs). METHODS: In this prospective birth cohort study, we assessed a random sample of mother-infant pairs (n = 138) living in Flanders, Belgium, with follow-up until the children were 3 years of age. We measured body mass index as standard deviation scores (BMI SDS) of children 1-3 years of age as well as pollutants measured in cord blood. RESULTS: DDE correlated with BMI SDS, with effect modification by maternal smoking and the child's age. At 1 year, children of smoking mothers had higher BMI SDS than did children of nonsmoking mothers. At 3 years, this difference was reduced because of the faster rate of decline in BMI SDS in the former group. This relationship held except for children with high levels of DDE. DDE had a small effect on BMI SDS at 3 years of age in children of nonsmoking mothers (difference in BMI SDS for DDE concentrations between the 90th and 10th percentiles = 0.13). On the other hand, smoking enhanced the relation between DDE and BMI SDS at 3 years (difference in BMI SDS for DDE concentrations between the 90th and 10th percentiles = 0.76). Increasing concentrations of PCBs were associated with higher BMI SDS values at all ages (parameter estimate = 0.003 +/- 0.001; p = 0.03). CONCLUSION: In this study we demonstrated that intrauterine exposure to DDE and PCBs is associated with BMI during early childhood. Future studies are warranted to confirm our findings and to assess possible mechanisms by which these pollutants could alter energy metabolism. JF - Environmental Health Perspectives AU - Verhulst, Stijn L AU - Nelen, Vera AU - Hond, Elly Den AU - Koppen, Gudrun AU - Beunckens, Caroline AU - Vael, Carl AU - Schoeters, Greet AU - Desager, Kristine PY - 2009 SP - 122 EP - 126 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Bismaleimides KW - Children KW - Age KW - Pollutants KW - Smoking KW - Standard deviation KW - Health KW - Copyrights KW - Blood KW - Flanders KW - Rope KW - Metabolism KW - Correlation KW - Estimates KW - Birth KW - Polychlorinated biphenyls KW - Hexachlorobenzene KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743358915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Intrauterine+Exposure+to+Environmental+Pollutants+and+Body+Mass+Index+during+the+First+3+Years+of+Life&rft.au=Verhulst%2C+Stijn+L%3BNelen%2C+Vera%3BHond%2C+Elly+Den%3BKoppen%2C+Gudrun%3BBeunckens%2C+Caroline%3BVael%2C+Carl%3BSchoeters%2C+Greet%3BDesager%2C+Kristine&rft.aulast=Verhulst&rft.aufirst=Stijn&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Meeting Report: Consensus Statement-Parkinson's Disease and the Environment: Collaborative on Health and the Environment and Parkinson's Action Network (CHE PAN) Conference 26-28 June 2007 AN - 743317747; 201004-31-0316653 (CE); 12129462 (EN) AB - BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disorder. People with PD, their families, scientists, health care providers, and the general public are increasingly interested in identifying environmental contributors to PD risk. METHODS: In June 2007, a multidisciplinary group of experts gathered in Sunnyvale, California, USA, to assess what is known about the contribution of environmental factors to PD. RESULTS: We describe the conclusions around which they came to consensus with respect to environmental contributors to PD risk. We conclude with a brief summary of research needs. CONCLUSIONS: PD is a complex disorder, and multiple different pathogenic pathways and mechanisms can ultimately lead to PD. Within the individual there are many determinants of PD risk, and within populations, the causes of PD are heterogeneous. Although rare recognized genetic mutations are sufficient to cause PD, these account for 10% of PD in the U.S. population, and incomplete penetrance suggests that environmental factors may be involved. Indeed, interplay among environmental factors and genetic makeup likely influences the risk of developing PD. There is a need for further understanding of how risk factors interact, and studying PD is likely to increase understanding of other neurodegenerative disorders. JF - Environmental Health Perspectives AU - Bronstein, Jeff AU - Carvey, Paul AU - Chen, Honglei AU - Cory-Slechta, Deborah AU - DiMonte, Donato AU - Duda, John AU - English, Paul AU - Goldman, Samuel AU - Grate, Stephen AU - Hansen, Johnni AU - Hoppin, Jane AU - Jewell, Sarah AU - Kamel, Freya AU - Koroshetz, Walter AU - Langston, James W AU - Logroscino, Giancarlo AU - Nelson, Lorene AU - Ravina, Bernard AU - Rocca, Walter PY - 2009 SP - 117 EP - 121 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Risk KW - Disorders KW - Health KW - Ecological risk assessment KW - Populations KW - Genetics KW - Networks KW - Determinants KW - Mutations KW - Bills KW - Meetings KW - Summaries KW - Health care KW - Copyrights KW - Pathways KW - Multidisciplinary KW - Parkinson's disease KW - Scientists KW - Conferences KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743317747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Meeting+Report%3A+Consensus+Statement-Parkinson%27s+Disease+and+the+Environment%3A+Collaborative+on+Health+and+the+Environment+and+Parkinson%27s+Action+Network+%28CHE+PAN%29+Conference+26-28+June+2007&rft.au=Bronstein%2C+Jeff%3BCarvey%2C+Paul%3BChen%2C+Honglei%3BCory-Slechta%2C+Deborah%3BDiMonte%2C+Donato%3BDuda%2C+John%3BEnglish%2C+Paul%3BGoldman%2C+Samuel%3BGrate%2C+Stephen%3BHansen%2C+Johnni%3BHoppin%2C+Jane%3BJewell%2C+Sarah%3BKamel%2C+Freya%3BKoroshetz%2C+Walter%3BLangston%2C+James+W%3BLogroscino%2C+Giancarlo%3BNelson%2C+Lorene%3BRavina%2C+Bernard%3BRocca%2C+Walter&rft.aulast=Bronstein&rft.aufirst=Jeff&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Long-Term Effects on Hypothalamic Neuropeptides after Developmental Exposure to Chlorpyrifos in Mice AN - 743265204; 201004-31-0316652 (CE); 12129461 (EN) AB - BACKGROUND: Increasing evidence from animal and human studies indicates that chlorpyrifos (CPF), similar to other organophosphorus insecticides still widely used, is a developmental neurotoxicant. Developmental exposure to CPF in rodents induces sex-dimorphic behavioral changes at adulthood, including social and agonistic responses, which suggests that CPF may interfere with maturation of neuroendocrine mechanisms. OBJECTIVES: We assessed the hypothesis that CPF affects the levels of neurohypophyseal hormones acting as modulators of social behavior in mammals, such as oxytocin (OT), arginine vasopressin (AVP), and prolactin (PRL). METHODS: Pregnant female mice were orally administered with either vehicle (peanut oil) or 3 or 6 mg/kg CPF on gestational day (GD) 15 to GD18, and offspring were treated subcutaneously with either vehicle or 1 or 3 mg/kg CPF on postnatal days (PNDs) 11 to PND14. Dose levels were chosen to avoid systemic toxicity and inhibition of brain acetylcholinesterase. Offspring were sacrificed at 5 months of age, and expression of OT, AVP, and PRL was analyzed in the hypothalamus by Western blot or enzyme-linked immunosorbent assay (ELISA) analysis. RESULTS: Both male and female mice showed dose-related enhancement of OT expression, with males presenting the more intense effect. AVP expression was significantly reduced in male mice at the higher prenatal and postnatal dose. We observed no significant effect on PRL expression in either sex. Overall, outcomes were mainly attributable to fetal exposure, whereas postnatal doses appeared to potentiate the prenatal effects. CONCLUSIONS: Our data indicate that developmental exposure to CPF may permanently interfere with specific key signaling proteins of the hypothalamic peptidergic system, with time-, dose-, and sex-related effects still evident at adulthood. JF - Environmental Health Perspectives AU - Tait, Sabrina AU - Ricceri, Laura AU - Venerosi, Aldina AU - Maranghi, Francesca AU - Mantovani, Alberto AU - Calamandrei, Gemma PY - 2009 SP - 112 EP - 116 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Mice KW - Males KW - Chlorpyrifos KW - Health KW - Females KW - Vehicles KW - Toxicity KW - ELISA KW - Hypothalamus KW - Insecticides KW - Mammals KW - Hormones KW - Modulators KW - Inhibition KW - Copyrights KW - Maturation KW - Peanuts KW - Sex KW - Brain KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743265204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Long-Term+Effects+on+Hypothalamic+Neuropeptides+after+Developmental+Exposure+to+Chlorpyrifos+in+Mice&rft.au=Tait%2C+Sabrina%3BRicceri%2C+Laura%3BVenerosi%2C+Aldina%3BMaranghi%2C+Francesca%3BMantovani%2C+Alberto%3BCalamandrei%2C+Gemma&rft.aulast=Tait&rft.aufirst=Sabrina&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Hydroxylated Metabolites of Polybrominated Diphenyl Ethers in Human Blood Samples from the United States AN - 743244896; 201004-31-0316656 (CE); 12129465 (EN) AB - BACKGROUND: A previous study from our laboratory showed that polybrominated diphenyl ethers (PBDEs) were metabolized to hydroxylated PBDEs (HO-PBDEs) in mice and that para-HO-PBDEs were the most abundant and, potentially, the most toxic metabolites. OBJECTIVE: The goal of this study was to determine the concentrations of HO-PBDEs in blood from pregnant women, who had not been intentionally or occupationally exposed to these flame retardants, and from their newborn babies. METHODS: Twenty human blood samples were obtained from a hospital in Indianapolis, Indiana, and analyzed for both PBDEs and HO-PBDEs using electron-capture negative-ionization gas chromatographic mass spectrometry. RESULTS: The metabolite pattern of HO-PBDEs in human blood was quite different from that found in mice; 5-HO-BDE-47 and 6-HO-BDE-47 were the most abundant metabolites of BDE-47, and 5'-HO-BDE-99 and 6'-HO-BDE-99 were the most abundant metabolites of BDE-99. The relative concentrations between precursor and corresponding metabolites indicated that BDE-99 was more likely to be metabolized than BDE-47 and BDE-100. In addition, three bromophenols were also detected as products of the cleavage of the diphenyl ether bond. The ratio of total hydroxylated metabolites relative to their PBDE precursors ranged from 0.10 to 2.8, indicating that hydroxylated metabolites of PBDEs were accumulated in human blood. CONCLUSIONS: The quite different PBDE metabolite pattern observed in humans versus mice indicates that different enzymes might be involved in the metabolic process. Although the levels of HO-PBDE metabolites found in human blood were low, these metabolites seemed to be accumulating. JF - Environmental Health Perspectives AU - Qiu, Xinghua AU - Bigsby, Robert M AU - Hites, Ronald A PY - 2009 SP - 93 EP - 98 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Metabolites KW - Human KW - Blood KW - Mice KW - Ethers KW - Health KW - Precursors KW - Enzymes KW - Flame retardants KW - Toxic KW - Mass spectrometry KW - Hospitals KW - Copyrights KW - Cleavage KW - Babies KW - Gas chromatography KW - Exposure KW - Toxicology KW - Bonding KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743244896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Hydroxylated+Metabolites+of+Polybrominated+Diphenyl+Ethers+in+Human+Blood+Samples+from+the+United+States&rft.au=Qiu%2C+Xinghua%3BBigsby%2C+Robert+M%3BHites%2C+Ronald+A&rft.aulast=Qiu&rft.aufirst=Xinghua&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia AN - 743237313; 201004-31-0316649 (CE); 12129458 (EN) AB - BACKGROUND: Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES: In this case-control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children. METHODS: We based our analyses on 550 cases of acute lymphoblastic leukemia (ALL), 100 cases of acute myeloid leukemia (AML), and one or two controls per case individually matched for sex, age, Hispanic status, and race. We conducted further analyses by cytogenetic subtype. We used conditional logistic regression techniques to adjust for income. RESULTS: ALL risk was significantly associated with paint exposure [odds ratio (OR) = 1.65; 95% confidence interval (CI), 1.26-2.15], with a higher risk observed when paint was used postnatally, by a person other than the mother, or frequently. The association was restricted to leukemia with translocations between chromosomes 12 and 21 (OR = 4.16; 95% CI, 1.66-10.4). We found no significant association between solvent use and ALL risk overall (OR = 1.15; 95% CI, 0.87-1.51) or for various cytogenetic subtypes, but we observed a significant association in the 2.0- to 5.9-year age group (OR = 1.55; 95% CI, 1.07-2.25). In contrast, a significant increased risk for AML was associated with solvent (OR = 2.54; 95% CI, 1.19-5.42) but not with paint exposure (OR = 0.64; 95% CI, 0.32-1.25). CONCLUSIONS: The association of ALL risk with paint exposure was strong, consistent with a causal relationship, but further studies are needed to confirm the association of ALL and AML risk with solvent exposure. JF - Environmental Health Perspectives AU - Scelo, Ghislaine AU - Metayer, Catherine AU - Zhang, Luoping AU - Wiemels, Joseph L AU - Aldrich, Melinda C AU - Selvin, Steve AU - Month, Stacy AU - Smith, Martyn T AU - Buffler, Patricia A PY - 2009 SP - 133 EP - 139 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Painting KW - Risk KW - Leukemias KW - Solvents KW - Crude oil KW - Regression analysis KW - Health KW - Age KW - Regression KW - Children KW - Households KW - Chromosomes KW - Race KW - Confidence intervals KW - Control equipment KW - Copyrights KW - Birth KW - Income KW - Sex KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743237313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Household+Exposure+to+Paint+and+Petroleum+Solvents%2C+Chromosomal+Translocations%2C+and+the+Risk+of+Childhood+Leukemia&rft.au=Scelo%2C+Ghislaine%3BMetayer%2C+Catherine%3BZhang%2C+Luoping%3BWiemels%2C+Joseph+L%3BAldrich%2C+Melinda+C%3BSelvin%2C+Steve%3BMonth%2C+Stacy%3BSmith%2C+Martyn+T%3BBuffler%2C+Patricia+A&rft.aulast=Scelo&rft.aufirst=Ghislaine&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Dietary Intake of Methionine, Cysteine, and Protein and Urinary Arsenic Excretion in Bangladesh AN - 743182041; 201004-31-0316655 (CE); 12129464 (EN) AB - BACKGROUND: In Bangladesh, millions of people are exposed to arsenic in drinking water; arsenic is associated with increased risk of cancer. Once ingested, arsenic is metabolized via methylation and excreted in urine. Knowledge about nutritional factors affecting individual variation in methylation is limited. OBJECTIVES: The purpose of this study was to examine associations between intakes of protein, methionine, and cysteine total urinary arsenic in a large population-based sample. METHODS: The study subjects were 10,402 disease-free residents of Araihazar, Bangladesh, who participated in the Health Effects of Arsenic Longitudinal Study (HEALS). Food intakes were assessed using a validated food frequency questionnaire developed for the study population. Nutrient composition was determined by using the U.S. Department of Agriculture National Nutrient Database for Standard Reference. Generalized estimating equations were used to examine association between total urinary arsenic across quintiles of nutrient intakes while controlling for arsenic exposure from drinking water and other predictors of urinary arsenic. RESULTS: Greater intakes of protein, methionine, and cysteine were associated with 10-15% greater total urinary arsenic excretion, after controlling for total energy intake, body weight, sex, age, tobacco use, and intake of some other nutrients. CONCLUSIONS: Given previously reported risks between lower rates of arsenic excretion and increased rates of cancer, these findings support the role of nutrition in preventing arsenic-related disease. JF - Environmental Health Perspectives AU - Heck, Julia E AU - Nieves, Jeri W AU - Chen, Yu AU - Parvez, Faruque AU - Brandt-Rauf, Paul W AU - Graziano, Joseph H AU - Slavkovich, Vesna AU - Howe, Geoffrey R AU - Ahsan, Habibul PY - 2009 SP - 99 EP - 104 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Arsenic KW - Intakes KW - Nutrients KW - Cysteine KW - Excretion KW - Methionine KW - Health KW - Proteins KW - Risk KW - Drinking water KW - Methylation KW - Mathematical analysis KW - Cancer KW - Databases KW - Estimating KW - Nutrition KW - Standards KW - Energy use KW - Agriculture KW - Article KW - EE 50:Water & Wastewater Treatment (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743182041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Dietary+Intake+of+Methionine%2C+Cysteine%2C+and+Protein+and+Urinary+Arsenic+Excretion+in+Bangladesh&rft.au=Heck%2C+Julia+E%3BNieves%2C+Jeri+W%3BChen%2C+Yu%3BParvez%2C+Faruque%3BBrandt-Rauf%2C+Paul+W%3BGraziano%2C+Joseph+H%3BSlavkovich%2C+Vesna%3BHowe%2C+Geoffrey+R%3BAhsan%2C+Habibul&rft.aulast=Heck&rft.aufirst=Julia&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Adult Women's Blood Mercury Concentrations Vary Regionally in the United States: Association with Patterns of Fish Consumption (NHANES 1999-2004) AN - 743165171; 201004-31-0316663 (CE); 12129472 (EN) AB - BACKGROUND: The current, continuous National Health and Nutrition Examination Survey (NHANES) has included blood mercury (BHg) and fish/shellfish consumption since it began in 1999. NHANES 1999-2004 data form the basis for these analyses. OBJECTIVES: This study was designed to determine BHg distributions within U.S. Census regions and within coastal and noncoastal areas among women of childbearing age, their association with patterns of fish consumption, and changes from 1999 through 2004. METHODS: We performed univariate and bivariate analyses to determine the distribution of BHg and fish consumption in the population and to investigate differences by geography, race/ethnicity, and income. We used multivariate analysis (regression) to determine the strongest predictors of BHg among geography, demographic factors, and fish consumption. RESULTS: Elevated BHg occurred more commonly among women of childbearing age living in coastal areas of the United States (approximately one in six women). Regionally, exposures differ across the United States: Northeast South and West Midwest. Asian women and women with higher income ate more fish and had higher BHg. Time-trend analyses identified reduced BHg and reduced intake of Hg in the upper percentiles without an overall reduction of fish consumption. CONCLUSIONS: BHg is associated with income, ethnicity, residence (census region and coastal proximity). From 1999 through 2004, BHg decreased without a concomitant decrease in fish consumption. Data are consistent with a shift over this time period in fish species in women's diets. JF - Environmental Health Perspectives AU - Mahaffey, Kathryn R AU - Clickner, Robert P AU - Jeffries, Rebecca A PY - 2009 SP - 47 EP - 53 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Fish KW - Mercury KW - Health KW - Income KW - Coastal KW - Census KW - Geography KW - Age KW - Blood KW - Nutrition KW - Bivariate analysis KW - Regression KW - Reduction KW - Adults KW - Race KW - Elevated KW - Diets KW - Proximity KW - Demographics KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743165171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Adult+Women%27s+Blood+Mercury+Concentrations+Vary+Regionally+in+the+United+States%3A+Association+with+Patterns+of+Fish+Consumption+%28NHANES+1999-2004%29&rft.au=Mahaffey%2C+Kathryn+R%3BClickner%2C+Robert+P%3BJeffries%2C+Rebecca+A&rft.aulast=Mahaffey&rft.aufirst=Kathryn&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Concentrations of Phthalate Metabolites in Milk, Urine, Saliva, and Serum of Lactating North Carolina Women AN - 743139383; 201004-31-0316659 (CE); 12129468 (EN) AB - BACKGROUND: Phthalates are ubiquitous in the environment, but concentrations in multiple media from breast-feeding U.S. women have not been evaluated. OBJECTIVES: The objective of this study was to accurately measure and compare the concentrations of oxidative monoester phthalate metabolites in milk and surrogate fluids (serum, saliva, and urine) of 33 lactating North Carolina women. METHODS: We analyzed serum, saliva, urine, and milk for the oxidative phthalate metabolites mono(3-carboxypropyl) phthalate, mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-hydroxyhexyl) phthalate, and mono(2-ethyl-5-oxohexyl) phthalate using isotope-dilution high-performance liquid chromatography tandem mass spectroscopy. Because only urine lacks esterases, we analyzed it for the hydrolytic phthalate monoesters. RESULTS: We detected phthalate metabolites in few milk ( 10%) and saliva samples. MECPP was detected in 80% of serum samples, but other metabolites were less common (3-22%). Seven of the 10 urinary metabolites were detectable in or = 85% of samples. Monoethyl phthalate had the highest mean concentration in urine. Metabolite concentrations differed by body fluid (urine serum milk and saliva). Questionnaire data suggest that frequent nail polish use, immunoglobulin A, and fasting serum glucose and triglyceride levels were increased among women with higher concentrations of urinary and/or serum phthalate metabolites; motor vehicle age was inversely correlated with certain urinary phthalate concentrations. CONCLUSIONS: Our data suggest that phthalate metabolites are most frequently detected in urine of lactating women and are less often detected in serum, milk, or saliva. Urinary phthalate concentrations reflect maternal exposure and do not represent the concentrations of oxidative metabolites in other body fluids, especially milk. JF - Environmental Health Perspectives AU - Hines, Erin P AU - Calafat, Antonia M AU - Silva, Manori J AU - Mendola, Pauline AU - Fenton, Suzanne E PY - 2009 SP - 86 EP - 92 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Phthalates KW - Metabolites KW - Serums KW - Milk KW - Urine KW - Saliva KW - Surgical implants KW - Biomedical materials KW - Health KW - Biocompatibility KW - Immunoglobulins KW - Liquid chromatography KW - Nail polishes KW - Correlation KW - Esterases KW - Motor vehicles KW - Fasting KW - Fluid flow KW - Fluid dynamics KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743139383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Concentrations+of+Phthalate+Metabolites+in+Milk%2C+Urine%2C+Saliva%2C+and+Serum+of+Lactating+North+Carolina+Women&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2002-08-27&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Financial+Times+World+Media+Abstracts&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - DDT Exposure of Zebrafish Embryos Enhances Seizure Susceptibility: Relationship to Fetal p,p'-DDE Burden and Domoic Acid Exposure of California Sea Lions AN - 743070406; 201004-31-0316661 (CE); 12129470 (EN) AB - BACKGROUND: California sea lions have a large body burden of organochlorine pesticides, and over the last decade they have also been subject to domoic acid poisoning. Domoic acid poisoning, previously recognized in adult animals, is now viewed as a major cause of prenatal mortality. The appearance of a chronic juvenile domoic acid disease in the sea lions, characterized by behavioral abnormalities and epilepsy, is consistent with early life poisoning and may be potentiated by organochlorine burden. OBJECTIVE: We investigated the interactive effect of DDT (dichlorodiphenyltrichloroethane) on neurodevelopment using a zebrafish (Danio rerio) model for seizure behavior to examine the susceptibility to domoic acid-induced seizures after completion of neurodevelopment. METHODS: Embryos were exposed (6-30 hr postfertilization) to either o,p'-DDT or p,p'-DDE (dichlorodiphenyldichloroethylene) during neurodevelopment via a 0.1% dimethyl sulfoxide solution. These larval (7 days postfertilization) fish were then exposed to either the seizure-inducing drug pentylenetetrazol (PTZ) or domoic acid; resulting seizure behavior was monitored and analyzed for changes using cameras and behavioral tracking software. RESULTS: Embryonic exposure to DDTs enhanced PTZ seizures and caused distinct and increased seizure behaviors to domoic acid, most notably a type of head-shaking behavior. CONCLUSION: These studies demonstrate that embryonic exposure to DDTs leads to asymptomatic animals at completion of neurodevelopment with greater sensitivity to domoic acid-induced seizures. The body burden levels of p,p'-DDE are close to the range recently found in fetal California sea lions and suggest a potential interactive effect of p,p'-DDE embryonic poisoning and domoic acid toxicity. JF - Environmental Health Perspectives AU - Tiedeken, Jessica A AU - Ramsdell, John S PY - 2009 SP - 68 EP - 73 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Seizing KW - Poisoning KW - DDT KW - Embryos KW - Health KW - Mathematical models KW - Zebrafish KW - Interactive KW - Animals KW - Exposure KW - Toxicity KW - Computer programs KW - Adults KW - Drugs KW - Tracking KW - Mortality KW - Software KW - Cameras KW - Fish KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743070406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=DDT+Exposure+of+Zebrafish+Embryos+Enhances+Seizure+Susceptibility%3A+Relationship+to+Fetal+p%2Cp%27-DDE+Burden+and+Domoic+Acid+Exposure+of+California+Sea+Lions&rft.au=Tiedeken%2C+Jessica+A%3BRamsdell%2C+John+S&rft.aulast=Tiedeken&rft.aufirst=Jessica&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Deducing in Vivo Toxicity of Combustion-Derived Nanoparticles from a Cell-Free Oxidative Potency Assay and Metabolic Activation of Organic Compounds AN - 743070388; 201004-31-0316662 (CE); 12129471 (EN) AB - BACKGROUND: The inhalation of combustion-derived nanoparticles (CDNPs) is believed to cause an oxidative stress response, which in turn may lead to pulmonary or even systemic inflammation. OBJECTIVE AND METHODS: In this study we assessed whether the in vivo inflammatory response--which is generally referred to as particle toxicity-of mice to CDNPs can be predicted in vitro by a cell-free ascorbate test for the surface reactivity or, more precisely, oxidative potency (OxPot) of particles. RESULTS: For six types of CDNPs with widely varying particle diameter (10-50 nm), organic content (OC; 1-20%), and specific Brunauer, Emmett, and Teller (BET) surface area (43-800 m2/g), OxPot correlated strongly with the in vivo inflammatory response (pulmonary polymorphonuclear neutrophil influx 24 hr after intratracheal particle instillation). However, for CDNPs with high organic content, OxPot could not explain the observed inflammatory response, possibly due to shielding of the OxPot of the carbon core of CDNPs by an organic coating. On the other hand, a pathway-specific gene expression screen indicated that, for particles rich in polycyclic aromatic hydrocarbon (PAHs), cytochrome P450 1A1 (CYP1A1) enzyme-mediated biotransformation of bio-available organics may generate oxidative stress and thus enhance the in vivo inflammatory response. CONCLUSION: The compensatory nature of both effects (shielding of carbon core and biotransformation of PAHs) results in a good correlation between inflammatory response and BET surface area for all CDNPs. Hence, the in vivo inflammatory response can either be predicted by BET surface area or by a simple quantitative model, based on in vitro OxPot and Cyp1a1 induction. JF - Environmental Health Perspectives AU - Stoeger, Tobias AU - Takenaka, Shinji AU - Frankenberger, Birgit AU - Ritter, Baerbel AU - Karg, Erwin AU - Maier, Konrad AU - Schulz, Holger AU - Schmid, Otmar PY - 2009 SP - 54 EP - 60 PB - U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES VL - 117 IS - 1 SN - 0091-6765, 0091-6765 KW - Civil Engineering (CE); Environmental Engineering (EN) KW - Biocompatibility KW - Inflammatory response KW - Surgical implants KW - Biomedical materials KW - In vivo tests KW - In vivo testing KW - Surface area KW - Carbon KW - Correlation KW - In vitro testing KW - Polyallylamine hydrochloride KW - Biotransformation KW - Health KW - Mathematical models KW - Shielding KW - Nanoparticles KW - Stresses KW - Activation KW - Toxicity KW - Article KW - EE 10:General Environmental Engineering (EN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743070388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Deducing+in+Vivo+Toxicity+of+Combustion-Derived+Nanoparticles+from+a+Cell-Free+Oxidative+Potency+Assay+and+Metabolic+Activation+of+Organic+Compounds&rft.au=Stoeger%2C+Tobias%3BTakenaka%2C+Shinji%3BFrankenberger%2C+Birgit%3BRitter%2C+Baerbel%3BKarg%2C+Erwin%3BMaier%2C+Konrad%3BSchulz%2C+Holger%3BSchmid%2C+Otmar&rft.aulast=Stoeger&rft.aufirst=Tobias&rft.date=2009-01-01&rft.volume=117&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-11-14 ER - TY - JOUR T1 - Critical comparison of numerical stress analysis tools for deep coal longwall panels under strong strata AN - 742929081; 2010-065907 AB - Proper employment of numerical stress analysis design tools is based on the demonstrated ability of a model to capture key elements of the geologic site model and accurately simulate how these elements interact with a mine design. While these tools have progressed markedly, they are, at heart, a gross simplification of the abundant complexity of a natural setting and its response to mining. A generic deep longwall site model was developed that includes aspects of the geology of deep coal mines in the Wasatch Plateau and Book Cliffs coal fields of Utah. The site model contains a set of common features and observations of how these features typically respond to mining. This site model was the basis for evaluating use of empirical, boundary element and volume element stress analysis tools to analyze the distribution of stress around a deep longwall panel. More specifically, this evaluation examined shifting of stress to panel abutments and gob, distribution of stress in the abutment and deformation and failure of bridging strata. Measurements of abutment stress changes at two sites in the Wasatch Plateau region were used to illustrate model calibration. Overall, these comparisons highlight the considerable differences between methods. Volume element tools can incorporate considerable detail and have fewer underlying assumptions, but this detail carries a considerable computational cost. Boundary element tools are much more efficient. However, this efficiency comes at the cost of added assumptions. These assumptions were challenged by the presence of a strong sandstone unit in the overburden, leading to boundary element results that depart significantly from volume element results. Empirical rules are the simplest, but are even more burdened by assumptions, many of which are implicit in underlying cases. Insight into the nature and impact of underlying assumptions in each method is essential to the proper use of results in mine design. JF - Transactions of Society for Mining, Metallurgy, and Exploration AU - Larson, M K AU - Whyatt, J K Y1 - 2009 PY - 2009 DA - 2009 SP - 49 EP - 60 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO VL - 326 SN - 1075-8623, 1075-8623 KW - United States KW - rock masses KW - mining KW - numerical models KW - underground mining KW - stress KW - stiffness KW - mechanical properties KW - Book Cliffs coal field KW - boundary conditions KW - rock mechanics KW - Wasatch Plateau coal field KW - longwall mining KW - Utah KW - design KW - pillars KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742929081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+Society+for+Mining%2C+Metallurgy%2C+and+Exploration&rft.atitle=Critical+comparison+of+numerical+stress+analysis+tools+for+deep+coal+longwall+panels+under+strong+strata&rft.au=Larson%2C+M+K%3BWhyatt%2C+J+K&rft.aulast=Larson&rft.aufirst=M&rft.date=2009-01-01&rft.volume=326&rft.issue=&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Transactions+of+Society+for+Mining%2C+Metallurgy%2C+and+Exploration&rft.issn=10758623&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 45 N1 - PubXState - CO N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Book Cliffs coal field; boundary conditions; design; longwall mining; mechanical properties; mining; numerical models; pillars; rock masses; rock mechanics; stiffness; stress; underground mining; United States; Utah; Wasatch Plateau coal field ER - TY - JOUR T1 - Regional bumps; case studies from the 1958 bump symposium AN - 742927087; 2010-065909 AB - A variety of dynamic failure cases with regional impact were described at a bump symposium held in 1958. These types of events, while rare, are of particular interest because their ability to impact a large area has disaster potential. These cases can be grouped into two broad classes of events by mechanism. These are (1) a slip along steeply dipping faults and (2) the fracturing of strong strata above or below the coal seam. Both failure modes produce dynamic or "shock" loads on the perimeter (roof, rib and floor) of mine openings. Special consideration should be given to these failure modes in the planning of deep coal mines, since their occurrence is not within the professional experience of many contemporary workers. In addition, their potential is not evaluated by many of the analysis tools commonly used to evaluate hazards in coal mine plans. JF - Transactions of Society for Mining, Metallurgy, and Exploration AU - Whyatt, J K AU - Varley, F Y1 - 2009 PY - 2009 DA - 2009 SP - 101 EP - 105 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO VL - 326 SN - 1075-8623, 1075-8623 KW - United States KW - bumps KW - mines KW - geologic hazards KW - floodplains KW - Sunnyside fault zone KW - stress KW - sandstone KW - fracturing KW - history KW - case studies KW - sedimentary rocks KW - Sunnyside Mine KW - fluvial features KW - Utah KW - clastic rocks KW - faults KW - Carbon County Utah KW - pillars KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742927087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+Society+for+Mining%2C+Metallurgy%2C+and+Exploration&rft.atitle=Regional+bumps%3B+case+studies+from+the+1958+bump+symposium&rft.au=Whyatt%2C+J+K%3BVarley%2C+F&rft.aulast=Whyatt&rft.aufirst=J&rft.date=2009-01-01&rft.volume=326&rft.issue=&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Transactions+of+Society+for+Mining%2C+Metallurgy%2C+and+Exploration&rft.issn=10758623&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 13 N1 - PubXState - CO N1 - Document feature - illus. incl. geol. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - bumps; Carbon County Utah; case studies; clastic rocks; faults; floodplains; fluvial features; fracturing; geologic hazards; history; mines; pillars; sandstone; sedimentary rocks; stress; Sunnyside fault zone; Sunnyside Mine; United States; Utah ER - TY - JOUR T1 - Assessing the potential for CO (sub 2) adsorption in a subbituminous coal, Huntly Coalfield, New Zealand, using small angle scattering techniques AN - 742898339; 2010-012090 AB - Small angle scattering techniques (SAXS and SANS) have been used to investigate the microstructural properties of the subbituminous coals (R (sub max) 0.42-0.45%) from the Huntly Coalfield, New Zealand. Samples were collected from the two thick (>5 m) coal seams in the coalfield and have been analysed for methane and carbon dioxide sorption capacity, petrography, pore size distribution, specific surface area and porosity. Specific surface area (SSA) available for carbon dioxide adsorption, extrapolated to a probe size of 4 A, ranged from 1.25 x 10 (super 6) cm (super -1) to 4.26 x 10 (super 6) cm (super -1) with total porosity varying from 16% to 25%. Porosity was found to be predominantly composed of microporosity, which contributed the majority of the available SSA. Although considerable variation was seen between samples, the results fit well with published rank trends. Gas holding capacity at the reservoir pressure (approximately 4 MPa) ranged from 2.63 to 4.18 m (super 3) /t for methane on a dry, ash-free basis (daf) and from 22.00 to 23.72 m (super 3) /t daf for carbon dioxide. The resulting ratio of CO (sub 2) :CH (sub 4) ranged from 5.7 to 8.6, with an average of 6.7:1. Holding capacities for both methane and carbon dioxide on a dry ash free basis (daf) were found to be correlated with sample microporosity. However, holding capacities for the two gases on an as analysed (aa) basis (that is including mineral matter and moisture), showed no such correlation. Carbon dioxide (aa) does show a negative correlation with both specific surface area and microporosity. As the coals have low inorganic matter content, the reversal is thought to be related to moisture which is likely concentrated in the pore size range 12.5-125 A. Methane holding capacity, both daf and aa, correlates with macroporosity, thus suggesting that the holding capacity of micropores is diminished by the presence of moisture in the pores. JF - International Journal of Coal Geology AU - Mares, Tennille E AU - Radlinski, Andrzej P AU - Moore, Tim A AU - Cookson, David J AU - Thiyagarajan, P AU - Ilavsky, J AU - Klepp, Jurgen A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 54 EP - 68 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - experimental studies KW - methane KW - carbon sequestration KW - Australasia KW - aliphatic hydrocarbons KW - alkanes KW - adsorption KW - coal fields KW - subbituminous coal KW - porosity KW - bituminous coal KW - carbon dioxide KW - small angle methods KW - size distribution KW - organic compounds KW - sedimentary rocks KW - specific surface area KW - coal KW - hydrocarbons KW - New Zealand KW - Huntly KW - coal deposits KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742898339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Assessing+the+potential+for+CO+%28sub+2%29+adsorption+in+a+subbituminous+coal%2C+Huntly+Coalfield%2C+New+Zealand%2C+using+small+angle+scattering+techniques&rft.au=Mares%2C+Tennille+E%3BRadlinski%2C+Andrzej+P%3BMoore%2C+Tim+A%3BCookson%2C+David+J%3BThiyagarajan%2C+P%3BIlavsky%2C+J%3BKlepp%2C+Jurgen&rft.aulast=Mares&rft.aufirst=Tennille&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.07.007 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - adsorption; aliphatic hydrocarbons; alkanes; Australasia; bituminous coal; carbon dioxide; carbon sequestration; coal; coal deposits; coal fields; experimental studies; Huntly; hydrocarbons; methane; New Zealand; organic compounds; porosity; sedimentary rocks; size distribution; small angle methods; specific surface area; subbituminous coal DO - http://dx.doi.org/10.1016/j.coal.2008.07.007 ER - TY - RPRT T1 - Summary of Advances in Autism Spectrum Disorder Research, 2009 AN - 742872600; ED509370 AB - Each year the members of the Interagency Autism Coordinating Committee identify recent research findings that made the most impact on the field. For the 2009 Summary of Advances, the IACC selected and summarized 20 studies that gave significant insight into the prevalence of autism spectrum disorder (ASD), the biology of the disorder, potential risk factors, and possible interventions. These articles were the top selections from a pool of 63 peer-reviewed articles published in 2009 that were nominated by the committee to reflect the most important work in biomedical and services research for ASD during the year--work that is critical to understanding the disorder and addressing the needs of people with ASD and their families. Articles appear in alphabetical order by first author. A full reference list is included at the end of the document. Y1 - 2009 PY - 2009 DA - 2009 SP - 18 PB - Interagency Autism Coordinating Committee. US Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Animals KW - At Risk Persons KW - Clinical Diagnosis KW - Drug Therapy KW - Parent Influence KW - Genetic Disorders KW - Brain KW - Pervasive Developmental Disorders KW - Intervention KW - Disability Identification KW - Racial Differences KW - Behavior Problems KW - Incidence KW - Research KW - Autism KW - Age Differences KW - Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742872600?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Titanium dioxide (TiO2) nanoparticles induce JB6 cell apoptosis through activation of the caspase-8/Bid and mitochondrial pathways. AN - 734237339; 20077182 AB - Titanium dioxide (TiO(2)), a commercially important material, is used in a wide variety of products. Although TiO(2) is generally regarded as nontoxic, the cytotoxicity, pathogenicity, and carcinogenicity of TiO(2) nanoparticles have been recently recognized. The present study investigated TiO(2) nanoparticle-induced cell apoptosis and molecular mechanisms involved in this process in a mouse epidermal (JB6) cell line. Using the 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay, TiO(2) nanoparticles were found to exhibit higher cytotoxicity than fine particles. YO-PRO-1 iodide (YP) staining demonstrated that both TiO(2) nanoparticles and fine particles induced cell death through apoptosis. The signaling pathways involved in TiO(2) particle-induced apoptosis were investigated. Western-blot analysis showed an activation of caspase-8, Bid, BAX, and caspase-3 and a decrease of Bcl-2 in JB6 cells treated with TiO(2) particles. Time-dependent poly(ADP)ribose polymerase (PARP) cleavage induced by TiO(2) nanoparticles was observed. TiO(2) particles also induced cytochrome c release from mitochondria to cytosol. Further studies demonstrated that TiO(2) nanoparticles induced significant changes in mitochondrial membrane permeability, suggesting the involvement of mitochondria in the apoptotic process. In conclusion, evidence indicated that TiO(2) nanoparticles exhibit higher cytotoxicity and apoptotic induction compared to fine particles in JB6 cells. Caspase-8/Bid and mitochondrial signaling may play a major role in TiO(2) nanoparticle-induced apoptosis involving the intrinsic mitochondrial pathway. Unraveling the complex mechanisms associated with these events may provide further insights into TiO(2) nanoparticle-induced pathogenicity and potential to induce carcinogenicity. JF - Journal of toxicology and environmental health. Part A AU - Zhao, Jinshun AU - Bowman, Linda AU - Zhang, Xingdong AU - Vallyathan, Val AU - Young, Shih-Houng AU - Castranova, Vincent AU - Ding, Min AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 1141 EP - 1149 VL - 72 IS - 19 SN - 1528-7394, 1528-7394 KW - BH3 Interacting Domain Death Agonist Protein KW - 0 KW - Bax protein, mouse KW - Bid protein, mouse KW - Proto-Oncogene Proteins c-bcl-2 KW - bcl-2-Associated X Protein KW - titanium dioxide KW - 15FIX9V2JP KW - Cytochromes c KW - 9007-43-6 KW - Titanium KW - D1JT611TNE KW - Parp1 protein, mouse KW - EC 2.4.2.30 KW - Poly (ADP-Ribose) Polymerase-1 KW - Poly(ADP-ribose) Polymerases KW - Casp8 protein, mouse KW - EC 3.4.22.- KW - Caspase 3 KW - Caspase 8 KW - Index Medicus KW - Animals KW - Cytochromes c -- metabolism KW - Epidermis -- cytology KW - Mice KW - Poly(ADP-ribose) Polymerases -- metabolism KW - bcl-2-Associated X Protein -- metabolism KW - Caspase 3 -- genetics KW - bcl-2-Associated X Protein -- genetics KW - Poly(ADP-ribose) Polymerases -- genetics KW - Cell Survival -- drug effects KW - Necrosis -- chemically induced KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Apoptosis -- drug effects KW - Mitochondrial Membranes -- drug effects KW - Gene Expression Regulation -- drug effects KW - Proto-Oncogene Proteins c-bcl-2 -- genetics KW - Cell Line KW - Caspase 3 -- metabolism KW - Caspase 8 -- metabolism KW - BH3 Interacting Domain Death Agonist Protein -- genetics KW - Titanium -- toxicity KW - BH3 Interacting Domain Death Agonist Protein -- metabolism KW - Caspase 8 -- genetics KW - Mitochondria -- metabolism KW - Nanoparticles -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734237339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Titanium+dioxide+%28TiO2%29+nanoparticles+induce+JB6+cell+apoptosis+through+activation+of+the+caspase-8%2FBid+and+mitochondrial+pathways.&rft.au=Zhao%2C+Jinshun%3BBowman%2C+Linda%3BZhang%2C+Xingdong%3BVallyathan%2C+Val%3BYoung%2C+Shih-Houng%3BCastranova%2C+Vincent%3BDing%2C+Min&rft.aulast=Zhao&rft.aufirst=Jinshun&rft.date=2009-01-01&rft.volume=72&rft.issue=19&rft.spage=1141&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390903091764 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-05 N1 - Date created - 2010-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15287390903091764 ER - TY - JOUR T1 - A guide to safe use of pain medicine for consumers. AN - 733121607; 19670027 AB - Editor's Note: The following bulletin was published by the Food and Drug Administration (FDA) and posted on its Consumer Health Information Web site at http://www.fda.gov/consumer/updates/painmeds022309.html on February 23, 2009. We present it here because it is important for clinicians to know what their patients are being told by other authoritative sources. JF - Journal of pain & palliative care pharmacotherapy AU - U.S. Food and Drug Administration AD - U.S. Food and Drug Administration Y1 - 2009 PY - 2009 DA - 2009 SP - 304 EP - 306 VL - 23 IS - 3 KW - Analgesics KW - 0 KW - Nonprescription Drugs KW - Index Medicus KW - United States KW - Severity of Illness Index KW - Nonprescription Drugs -- adverse effects KW - United States Food and Drug Administration KW - Nonprescription Drugs -- therapeutic use KW - Humans KW - Pain -- etiology KW - Pain -- drug therapy KW - Analgesics -- therapeutic use KW - Analgesics -- adverse effects KW - Consumer Health Information UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733121607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.atitle=A+guide+to+safe+use+of+pain+medicine+for+consumers.&rft.au=U.S.+Food+and+Drug+Administration&rft.aulast=U.S.+Food+and+Drug+Administration&rft.aufirst=&rft.date=2009-01-01&rft.volume=23&rft.issue=3&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.issn=1536-0539&rft_id=info:doi/10.1080%2F15360280903099117 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-30 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15360280903099117 ER - TY - JOUR T1 - An analysis of injury claims from low-seam coal mines. AN - 67388131; 19527819 AB - The restricted workspace present in low-seam coal mines forces workers to adopt awkward working postures (kneeling and stooping), which place high physical demands on the knee and lower back. This article provides an analysis of injury claims for eight mining companies operating low-seam coal mines during calendar years 1996-2008. All cost data were normalized using data on the cost of medical care (MPI) as provided by the U.S. Bureau of Labor Statistics. Results of the analysis indicate that the knee was the body part that led in terms of claim cost ($4.2 million), followed by injuries to the lower back ($2.7 million). While the average cost per injury for these body parts was $13,100 and $14,400, respectively (close to the average cost of an injury overall), the high frequency of these injuries resulted in their preeminence in terms of cost. Analysis of data from individual mining companies suggest that knee and lower back injuries were a consistent problem across companies, as these injuries were each among the top five most costly part of body for seven out of eight companies studied. APPLICATION/IMPACT: Results of this investigation suggest that efforts to reduce the frequency of knee and low back injuries in low-seam mines have the potential to create substantial cost savings. JF - Journal of safety research AU - Gallagher, Sean AU - Moore, Susan AU - Dempsey, Patrick G AD - National Institute for Occupational Safety and Health, Mining Injury Prevention Branch, Pittsburgh, PA 15236-0070, USA. sfg9@cdc.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 233 EP - 237 VL - 40 IS - 3 KW - Index Medicus KW - Humans KW - Posture KW - United States -- epidemiology KW - Wounds and Injuries -- epidemiology KW - Wounds and Injuries -- classification KW - Confined Spaces KW - Occupational Exposure -- adverse effects KW - Coal Mining KW - Insurance Claim Review KW - Wounds and Injuries -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67388131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+safety+research&rft.atitle=An+analysis+of+injury+claims+from+low-seam+coal+mines.&rft.au=Gallagher%2C+Sean%3BMoore%2C+Susan%3BDempsey%2C+Patrick+G&rft.aulast=Gallagher&rft.aufirst=Sean&rft.date=2009-01-01&rft.volume=40&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+safety+research&rft.issn=1879-1247&rft_id=info:doi/10.1016%2Fj.jsr.2009.04.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-22 N1 - Date created - 2009-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jsr.2009.04.003 ER - TY - JOUR T1 - Biotransformation of acridine by Mycobacterium vanbaalenii. AN - 67123259; 18717621 AB - Cultures of Mycobacterium vanbaalenii strain PYR-1 in a liquid medium were exposed to the toxic environmental contaminant acridine (260 microM). After incubation for 7 d, the cultures were extracted with ethyl acetate. Metabolites were purified using high-performance liquid chromatography and analyzed by mass spectrometry and 1H nuclear magnetic resonance spectroscopy. Four metabolites, 9,10-dihydroacridine, 4-hydroxyacridine, acridine cis-1 ,2-dihydrodiol, and acridin-9(10H)-one, were identified. JF - Environmental toxicology and chemistry AU - Sutherland, John B AU - Heinze, Thomas M AU - Pearce, Mason G AU - Deck, Joanna AU - Williams, Anna J AU - Freeman, James P AD - Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA. john.sutherland@fda.hhs.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 61 EP - 64 VL - 28 IS - 1 SN - 0730-7268, 0730-7268 KW - Acridines KW - 0 KW - Index Medicus KW - Spectrometry, Mass, Electrospray Ionization KW - Biotransformation KW - Spectrophotometry, Ultraviolet KW - Chromatography, High Pressure Liquid KW - Mycobacterium -- metabolism KW - Acridines -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67123259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Biotransformation+of+acridine+by+Mycobacterium+vanbaalenii.&rft.au=Sutherland%2C+John+B%3BHeinze%2C+Thomas+M%3BPearce%2C+Mason+G%3BDeck%2C+Joanna%3BWilliams%2C+Anna+J%3BFreeman%2C+James+P&rft.aulast=Sutherland&rft.aufirst=John&rft.date=2009-01-01&rft.volume=28&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=07307268&rft_id=info:doi/10.1897%2F08-206.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-08 N1 - Date created - 2009-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1897/08-206.1 ER - TY - JOUR T1 - Reactive oxygen species- and nitric oxide-mediated lung inflammation and mitochondrial dysfunction in wild-type and iNOS-deficient mice exposed to diesel exhaust particles. AN - 67003685; 19267316 AB - Pulmonary responses to diesel exhaust particles (DEP) exposure are mediated through enhanced production of reactive oxygen species (ROS) and nitric oxide (NO) by alveolar macrophages (AM). The current study examined the differential roles of ROS and NO in DEP-induced lung injury using C57B/6J wild-type (WT) and inducible NO synthase knockout (iNOS KO) mice. Mice exposed by pharyngeal aspiration to DEP or carbon black particles (CB) (35 mg/kg) showed an inflammatory profile that included neutrophil infiltration, increased lactate dehydrogenase (LDH) activity, and elevated albumin content in bronchoalveolar lavage fluid (BALF) at 1, 3, and 7 d postexposure. The organic extract of DEP (DEPE) did not induce an inflammatory response. Comparing WT to iNOS KO mice, the results show that NO enhanced DEP-induced neutrophils infiltration and plasma albumin content in BALF and upregulated the production of the pro-inflammatory cytokine interleukin 12 (IL-12) by AM. DEP-exposed AM from iNOS KO mice displayed diminished production of IL-12 and, in response to ex vivo lipopolysaccharide (LPS) challenge, decreased production of IL-12 but increased production of IL-10 when compared to cells from WT mice. DEP, CB, but not DEPE, induced DNA damage and mitochondria dysfunction in AM, however, that is independent of cellular production of NO. These results demonstrate that DEP-induced immune/inflammatory responses in mice are regulated by both ROS- and NO-mediated pathways. NO did not affect ROS-mediated mitochondrial dysfunction and DNA damage but upregulated IL-12 and provided a counterbalance to the ROS-mediated adaptive stress response that downregulates IL-12 and upregulates IL-10. JF - Journal of toxicology and environmental health. Part A AU - Zhao, Hongwen AU - Ma, Joseph K AU - Barger, Mark W AU - Mercer, Robert R AU - Millecchia, Lyndell AU - Schwegler-Berry, Diane AU - Castranova, Vince AU - Ma, Jane Y AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 560 EP - 570 VL - 72 IS - 8 SN - 1528-7394, 1528-7394 KW - Cytokines KW - 0 KW - Particulate Matter KW - Reactive Oxygen Species KW - Vehicle Emissions KW - Nitric Oxide KW - 31C4KY9ESH KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Index Medicus KW - Microscopy, Confocal KW - Pulmonary Alveoli -- pathology KW - Animals KW - Comet Assay KW - DNA Damage KW - Cytokines -- metabolism KW - Mice KW - Biological Availability KW - Mice, Knockout KW - Microscopy, Electron, Transmission KW - Cells, Cultured KW - Bronchoalveolar Lavage Fluid -- cytology KW - L-Lactate Dehydrogenase -- metabolism KW - Particulate Matter -- toxicity KW - Nitric Oxide -- toxicity KW - Pneumonia -- chemically induced KW - Mitochondrial Diseases -- pathology KW - Vehicle Emissions -- toxicity KW - Particulate Matter -- pharmacokinetics KW - Nitric Oxide Synthase Type II -- physiology KW - Reactive Oxygen Species -- toxicity KW - Nitric Oxide Synthase Type II -- genetics KW - Mitochondrial Diseases -- chemically induced KW - Pneumonia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67003685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Reactive+oxygen+species-+and+nitric+oxide-mediated+lung+inflammation+and+mitochondrial+dysfunction+in+wild-type+and+iNOS-deficient+mice+exposed+to+diesel+exhaust+particles.&rft.au=Zhao%2C+Hongwen%3BMa%2C+Joseph+K%3BBarger%2C+Mark+W%3BMercer%2C+Robert+R%3BMillecchia%2C+Lyndell%3BSchwegler-Berry%2C+Diane%3BCastranova%2C+Vince%3BMa%2C+Jane+Y&rft.aulast=Zhao&rft.aufirst=Hongwen&rft.date=2009-01-01&rft.volume=72&rft.issue=8&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390802706330 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-10 N1 - Date created - 2009-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15287390802706330 ER - TY - JOUR T1 - Microbiological quality of ready-to-eat food served in schools in Wales, United Kingdom. AN - 66911861; 19205487 AB - A survey of the general microbiological quality of ready-to-eat food served in schools was undertaken across Wales, United Kingdom. Of the 2,351 samples taken, four were identified as containing unsatisfactory counts of Escherichia coli, four contained unsatisfactory counts of Staphylococcus aureus, and one contained an unacceptable count of Bacillus cereus when compared with guidelines for the microbiological quality of ready-to-eat food published by the United Kingdom Public Health Laboratory Service in 2000. No samples contained detectable levels of Salmonella, Listeria species, or Clostridium perfringens. When compared with data on the general microbiological quality of food available in Wales, the food sampled from schools was of relatively better microbiological quality. JF - Journal of food protection AU - Meldrum, R J AU - Mannion, P T AU - Garside, J AU - Welsh Food Microbiological Forum AD - Public Health Laboratory, National Public Health Service for Wales, Llandough Hospital, Penlan Road, Penarth CF64 2XX, UK. richard.meldrum@nphs.wales.nhs.uk ; Welsh Food Microbiological Forum Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 197 EP - 201 VL - 72 IS - 1 SN - 0362-028X, 0362-028X KW - Index Medicus KW - Food Microbiology KW - Consumer Product Safety KW - Escherichia coli -- isolation & purification KW - Staphylococcus aureus -- isolation & purification KW - Humans KW - Colony Count, Microbial KW - Child KW - Wales KW - Bacillus cereus -- isolation & purification KW - Quality Control KW - Food Analysis -- methods KW - Schools KW - Food Services -- standards KW - Food Contamination -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66911861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Microbiological+quality+of+ready-to-eat+food+served+in+schools+in+Wales%2C+United+Kingdom.&rft.au=Meldrum%2C+R+J%3BMannion%2C+P+T%3BGarside%2C+J%3BWelsh+Food+Microbiological+Forum&rft.aulast=Meldrum&rft.aufirst=R&rft.date=2009-01-01&rft.volume=72&rft.issue=1&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2009-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inactivation of Yersinia pseudotuberculosis 197 and Francisella tularensis LVS in beverages by high pressure processing. AN - 66911656; 19205479 AB - In 2003, the U.S. Department of Health and Human Services announced a new research program to develop technologies and strategies to prevent and minimize potential food safety and security threats. The threat of terrorist attacks against the nation's food supplies has created the need to study microorganisms not typically associated with foodborne illness. High-pressure processing has been proposed as a treatment to reduce Yersinia pestis and Francisella tularensis LVS levels in beverages. The objectives of this work were to determine the pressure resistance of Y. pseudotuberculosis 197 (surrogate for Y. pestis) and F. tularensis LVS (vaccine strain). For each bacterium, samples of ultrahigh-temperature pasteurized skim milk and pasteurized reduced-acid orange juice (pH ca. 4.2) were inoculated at a minimum level of 5 log CFU/ml. Ten-milliliter samples of the inoculated product were vacuum sealed in polyester pouches and subjected to pressures of 300 and 500 MPa for holding times ranging from 30 s to 6 min. One set of trials was performed at an initial temperature of 10 degrees C and another at 25 degrees C. Processed samples were immediately plated and enumerated. A pressure treatment of 300 MPa at 25 degrees C for less than 6 min was not sufficient to achieve a 5-log reduction of Y. pseudotuberculosis 197 or F. tularensis LVS in milk. However, a pressure treatment of 500 MPa was effective at hold times as low as 30 s. Overall, F. tularensis LVS demonstrated less pressure resistance than Y. pseudotuberculosis 197. Based on these findings, a high-pressure process designed to inactivate 5 log CFU of Y. pseudotuberculosis 197 per ml and F. tularensis LVS in orange juice or milk should be set at or above 500 MPa with a hold time of 2 min or greater. JF - Journal of food protection AU - Schlesser, Joseph E AU - Parisi, Brian AD - Food and Drug Administration, National Center for Food Safety and Technology, Moffett Campus, Summit-Argo, Illinois 60501, USA. joseph.schlesser@fda.hhs.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 165 EP - 168 VL - 72 IS - 1 SN - 0362-028X, 0362-028X KW - Index Medicus KW - Animals KW - Consumer Product Safety KW - Humans KW - Temperature KW - Milk -- microbiology KW - Colony Count, Microbial KW - Citrus sinensis -- microbiology KW - Time Factors KW - Food Contamination -- prevention & control KW - Hydrostatic Pressure KW - Beverages -- microbiology KW - Food Handling -- methods KW - Food Contamination -- analysis KW - Yersinia pseudotuberculosis -- growth & development KW - Francisella tularensis -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66911656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Inactivation+of+Yersinia+pseudotuberculosis+197+and+Francisella+tularensis+LVS+in+beverages+by+high+pressure+processing.&rft.au=Schlesser%2C+Joseph+E%3BParisi%2C+Brian&rft.aulast=Schlesser&rft.aufirst=Joseph&rft.date=2009-01-01&rft.volume=72&rft.issue=1&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2009-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sorafenib for the treatment of unresectable hepatocellular carcinoma. AN - 66876004; 19144678 AB - To describe the U.S. Food and Drug Administration (FDA) review and approval of sorafenib (Nexavar; Bayer Pharmaceuticals Corp., Montville, NJ, and Onyx Pharmaceuticals Corp., Emeryville, CA), an oral kinase inhibitor, for the treatment of patients with unresectable hepatocellular carcinoma (HCC). The FDA independently analyzed an international, double-blind, placebo-controlled trial comparing the effect of best supportive care plus sorafenib or matching placebo on overall survival. Eligible patients had unresectable, biopsy-proven HCC and had not received prior systemic therapy. Among the 602 randomized patients (placebo, 303; sorafenib, 299), baseline characteristics were well balanced, and 97% were Child-Pugh score A. HCC was "advanced" in 70% overall, as defined by extrahepatic metastases or by tumor radiographically visible in venous structures outside the liver. Underlying liver diseases included hepatitis B (18%), hepatitis C (28%), and alcohol-related (26%). The trial was stopped following a prespecified second interim analysis showing a statistically significant survival advantage for sorafenib [median, 10.7 vs 7.9 months; hazard ratio, 0.69 (95% confidence interval, (0.55, 0.87)), p = 0.00058]. Adverse events in sorafenib-treated patients included diarrhea in 55% (grade 3, 10%), hand-foot syndrome in 21% (grade 3, 8%), rash in 19% (grade 3, 1%), and cardiac ischemia or infarction in 2.7% (versus 1.3% for placebo). On sorafenib, treatment-emergent hypertension occurred in 9% of patients (placebo, 4%) and was grade 3 in 4% (placebo, 1%); elevated serum lipase occurred in 40% (placebo, 37%); hypophosphatemia occurred in 35% (placebo, 11%). Sorafenib is the first systemic therapy to demonstrate a survival benefit in a randomized trial for unresectable HCC and has received FDA approval for this indication. JF - The oncologist AU - Kane, Robert C AU - Farrell, Ann T AU - Madabushi, Rajanikanth AU - Booth, Brian AU - Chattopadhyay, Somesh AU - Sridhara, Rajeshwari AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993-0004, USA. robert.kane@fda.hhs.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 95 EP - 100 VL - 14 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Benzenesulfonates KW - Phenylurea Compounds KW - Protein Kinase Inhibitors KW - Pyridines KW - Niacinamide KW - 25X51I8RD4 KW - sorafenib KW - 9ZOQ3TZI87 KW - Index Medicus KW - United States KW - Randomized Controlled Trials as Topic KW - United States Food and Drug Administration KW - Humans KW - Drug Approval KW - Niacinamide -- analogs & derivatives KW - Benzenesulfonates -- therapeutic use KW - Benzenesulfonates -- adverse effects KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- adverse effects KW - Carcinoma, Hepatocellular -- drug therapy KW - Liver Neoplasms -- drug therapy KW - Pyridines -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Pyridines -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66876004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Sorafenib+for+the+treatment+of+unresectable+hepatocellular+carcinoma.&rft.au=Kane%2C+Robert+C%3BFarrell%2C+Ann+T%3BMadabushi%2C+Rajanikanth%3BBooth%2C+Brian%3BChattopadhyay%2C+Somesh%3BSridhara%2C+Rajeshwari%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Kane&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=14&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2008-0185 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-25 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Oncologist. 2009 Jan;14(1):92-4 [19144679] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2008-0185 ER - TY - JOUR T1 - Neonatal NMDA receptor antagonist treatments have no effects on prepulse inhibition of postnatal day 25 Sprague-Dawley rats. AN - 66854449; 19038286 AB - Glutamate activation of the NMDA receptor is essential for neuronal differentiation, migration, and survival. Treatment with NMDA receptor antagonists, such as ketamine (KET) or phencyclidine (PCP), can trigger apoptosis in neonatal rats. However, L-carnitine (LC) treatment appears to prevent glutamate-induced toxicity in the developing CNS. Previously, we described altered preweaning behaviors (i.e., abnormal home cage, slant board and forelimb hang behaviors) resulting from neonatal PCP and KET treatment. Those adverse effects of KET were somewhat ameliorated by LC [Boctor SY, Wang C, Ferguson SA. Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague-Dawley rats. Toxicol Sci 2008;106:172-9]. Here, a portion of those subjects were evaluated for prepulse inhibition (PPI) of the acoustic startle response at postnatal day (PND) 25 since previous reports described PCP-induced effects on this response. Rats were subcutaneously treated with: saline; 10 mg/kg PCP (1x/day) on PNDs 7, 9 and 11; 20 mg/kg KET (6 injections every 2h on PND 7); or a similar regimen of ketamine and 250 mg/kg LC on PND 7, with a single injection of 250 mg/kg LC on PNDs 8-11 (KLC). Male and female rats were assessed using a standard PPI paradigm with prepulses of 68, 78 and 82 dB. Body weight was decreased 17-21% and whole brain weight was decreased 10% in PCP-treated rats. Specifically, cerebellar weight was significantly less in PCP-treated rats relative to control. Despite the magnitude of those PCP-induced changes, startle response in normal pulse only trials and percent of PPI in PCP-, KET-, and KLC-treated groups were comparable to controls. Average latency to maximum startle was 2.6 ms less in females than males (p<0.007); there were no other significant sex effects. The lack of neonatal PCP treatment on later PPI is similar to that reported by Rasmussen et al. [Rasmussen BA, O'Neil J, Manaye KF, Perry DC, Tizabi Y. Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats. Psychopharmacology (Berl) 2007; 190: 43-9.], and indicates that neonatal PCP-induced effects on PPI [Wang C, McInnis J, Ross-Sanchez M, Shinnick-Gallagher P, Wiley JL, Johnson KM. Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia. Neuroscience 2001; 107: 535-50.] appear difficult to replicate. JF - Neurotoxicology AU - Boctor, Sherin Y AU - Ferguson, Sherry A AD - Department of Interdisciplinary Biomedical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States. Sherin.Boctor@fda.hhs.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 151 EP - 154 VL - 30 IS - 1 SN - 0161-813X, 0161-813X KW - Receptors, N-Methyl-D-Aspartate KW - 0 KW - Ketamine KW - 690G0D6V8H KW - Phencyclidine KW - J1DOI7UV76 KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Reflex, Startle -- drug effects KW - Rats, Sprague-Dawley KW - Sex Characteristics KW - Cerebellum -- drug effects KW - Carnitine -- pharmacology KW - Body Weight -- drug effects KW - Postpartum Period KW - Male KW - Female KW - Organ Size -- drug effects KW - Phencyclidine -- pharmacology KW - Phencyclidine -- antagonists & inhibitors KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Phencyclidine -- administration & dosage KW - Ketamine -- antagonists & inhibitors KW - Ketamine -- administration & dosage KW - Ketamine -- pharmacology KW - Inhibition (Psychology) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66854449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Neonatal+NMDA+receptor+antagonist+treatments+have+no+effects+on+prepulse+inhibition+of+postnatal+day+25+Sprague-Dawley+rats.&rft.au=Boctor%2C+Sherin+Y%3BFerguson%2C+Sherry+A&rft.aulast=Boctor&rft.aufirst=Sherin&rft.date=2009-01-01&rft.volume=30&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2008.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-13 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuro.2008.10.011 ER - TY - JOUR T1 - Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers. AN - 66820134; 19049393 AB - Nanotechnology is an emerging field that demands urgent development of adequate toxicology and risk assessment. The previous experimental data on carbon nanotube respiratory exposure strongly suggest the need for complex evaluation of potential toxicity. Our work demonstrates that after carbon nanotube deposition in the lung, acute local and systemic responses are activated and characterized by a blood gene and protein expression signature. The approach described here will foster the development of biomarkers for application in human screening of nanoparticle exposure. JF - Nano letters AU - Erdely, Aaron AU - Hulderman, Tracy AU - Salmen, Rebecca AU - Liston, Angie AU - Zeidler-Erdely, Patti C AU - Schwegler-Berry, Diane AU - Castranova, Vincent AU - Koyama, Shozo AU - Kim, Yoong-Ahm AU - Endo, Morinobu AU - Simeonova, Petia P AD - Toxicology and Molecular Biology Branch and Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 36 EP - 43 VL - 9 IS - 1 SN - 1530-6984, 1530-6984 KW - Biomarkers KW - 0 KW - Blood Proteins KW - Nanotubes, Carbon KW - Particulate Matter KW - Index Medicus KW - Animals KW - Feasibility Studies KW - Mice, Inbred C57BL KW - Mice KW - Administration, Inhalation KW - Male KW - Particulate Matter -- administration & dosage KW - Nanotubes, Carbon -- chemistry KW - Particulate Matter -- pharmacokinetics KW - Nanotubes, Carbon -- analysis KW - Environmental Exposure -- analysis KW - Lung -- drug effects KW - Lung -- metabolism KW - Blood Proteins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66820134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nano+letters&rft.atitle=Cross-talk+between+lung+and+systemic+circulation+during+carbon+nanotube+respiratory+exposure.+Potential+biomarkers.&rft.au=Erdely%2C+Aaron%3BHulderman%2C+Tracy%3BSalmen%2C+Rebecca%3BListon%2C+Angie%3BZeidler-Erdely%2C+Patti+C%3BSchwegler-Berry%2C+Diane%3BCastranova%2C+Vincent%3BKoyama%2C+Shozo%3BKim%2C+Yoong-Ahm%3BEndo%2C+Morinobu%3BSimeonova%2C+Petia+P&rft.aulast=Erdely&rft.aufirst=Aaron&rft.date=2009-01-01&rft.volume=9&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Nano+letters&rft.issn=15306984&rft_id=info:doi/10.1021%2Fnl801828z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-30 N1 - Date created - 2009-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/nl801828z ER - TY - JOUR T1 - Urinary phthalate metabolite concentrations among workers in selected industries: a pilot biomonitoring study. AN - 66805735; 18948546 AB - Phthalates are used as plasticizers and solvents in industrial, medical and consumer products; however, occupational exposure information is limited. We sought to obtain preliminary information on occupational exposures to diethyl phthalate (DEP), di-n-butyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP) by analyzing for their metabolites in urine samples collected from workers in a cross-section of industries. We also obtained data on metabolites of dimethyl phthalate (DMP), benzylbutyl phthalate (BzBP), di-isobutyl phthalate and di-isononyl phthalate. We recruited 156 workers in 2003-2005 from eight industry sectors. We assessed occupational contribution by comparing end-shift metabolite concentrations to the US general population. Evidence of occupational exposure to DEHP was strongest in polyvinyl chloride (PVC) film manufacturing, PVC compounding and rubber boot manufacturing where geometric mean (GM) end-shift concentrations of DEHP metabolites exceeded general population levels by 8-, 6- and 3-fold, respectively. Occupational exposure to DBP was most evident in rubber gasket, phthalate (raw material) and rubber hose manufacturing, with DBP metabolite concentrations exceeding general population levels by 26-, 25- and 10-fold, respectively, whereas DBP exposure in nail-only salons (manicurists) was only 2-fold higher than in the general population. Concentrations of DEP and DMP metabolites in phthalate manufacturing exceeded general population levels by 4- and >1000-fold, respectively. We also found instances where GM end-shift concentrations of some metabolites exceeded general population concentrations even when no workplace use was reported, e.g. BzBP in rubber hose and rubber boot manufacturing. In summary, using urinary metabolites, we successfully identified workplaces with likely occupational phthalate exposure. Additional work is needed to distinguish occupational from non-occupational sources in low-exposure workplaces. JF - The Annals of occupational hygiene AU - Hines, Cynthia J AU - Nilsen Hopf, Nancy B AU - Deddens, James A AU - Calafat, Antonia M AU - Silva, Manori J AU - Grote, Ardith A AU - Sammons, Deborah L AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, USA. chines@cdc.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 1 EP - 17 VL - 53 IS - 1 KW - Biomarkers KW - 0 KW - Phthalic Acids KW - Plasticizers KW - Solvents KW - phthalic acid KW - 6O7F7IX66E KW - Index Medicus KW - Solvents -- pharmacokinetics KW - Humans KW - Adult KW - Plasticizers -- pharmacokinetics KW - Biomarkers -- urine KW - Pilot Projects KW - Middle Aged KW - Male KW - Female KW - Environmental Monitoring -- methods KW - Phthalic Acids -- urine KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66805735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Urinary+phthalate+metabolite+concentrations+among+workers+in+selected+industries%3A+a+pilot+biomonitoring+study.&rft.au=Hines%2C+Cynthia+J%3BNilsen+Hopf%2C+Nancy+B%3BDeddens%2C+James+A%3BCalafat%2C+Antonia+M%3BSilva%2C+Manori+J%3BGrote%2C+Ardith+A%3BSammons%2C+Deborah+L&rft.aulast=Hines&rft.aufirst=Cynthia&rft.date=2009-01-01&rft.volume=53&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmen066 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2009-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annhyg/men066 ER - TY - JOUR T1 - Pediatric drug surveillance and the Food and Drug Administration's adverse event reporting system: an overview of reports, 2003-2007. AN - 66802077; 19009550 AB - Our objective was to examine the numbers and characteristics of US pediatric adverse events (AEs) reported to the Food and Drug Administration (FDA)'s adverse event reporting system (AERS) for 5 years following implementation of the Best Pharmaceuticals for Children Act (BPCA) in 2002. We analyzed reports in AERS received by FDA from January 1, 2003 to January 1, 2008 for overall numbers, age, gender, and seriousness of outcome in children and adults. Pediatric and adult age groups (50 years of age) were further evaluated for most frequently reported suspect drug classes and AEs. Seventy-two percent of 815 267 crude count reports had specified age information. Six percent of the total reports with age information reported age <18 years. Numbers of AEs being reported for children have remained steady, while those for adults have increased. The proportion of serious AEs reported was similar for pediatrics as compared to adults. Frequently reported suspect drug classes noted in pediatric age groups that were not observed in adults included anticonvulsants, attention deficit hyperactivity disorder (ADHD), anti-acne, and respiratory medications. This overview highlights the need for strengthening the passive drug surveillance system from a pediatric perspective, as well as investing in more active surveillance systems. Drug safety initiatives to better capture risk information in order to balance the risk/benefit of drug use in children. JF - Pharmacoepidemiology and drug safety AU - Johann-Liang, Rosemary AU - Wyeth, Jo AU - Chen, Min AU - Cope, Judith U AD - Health Resources and Services Administration, Department of Health and Human Services, Rockville, MD 20857, USA. Rjohann-liang@hrsa.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 24 EP - 27 VL - 18 IS - 1 KW - Anticonvulsants KW - 0 KW - Dermatologic Agents KW - Index Medicus KW - United States KW - Severity of Illness Index KW - Young Adult KW - Age Factors KW - Acne Vulgaris -- drug therapy KW - Respiratory Tract Diseases -- drug therapy KW - Humans KW - Anticonvulsants -- adverse effects KW - Child KW - Attention Deficit Disorder with Hyperactivity -- drug therapy KW - Child, Preschool KW - Infant KW - Adult KW - Middle Aged KW - Adolescent KW - Dermatologic Agents -- adverse effects KW - United States Food and Drug Administration KW - Drug-Related Side Effects and Adverse Reactions KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66802077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+drug+safety&rft.atitle=Pediatric+drug+surveillance+and+the+Food+and+Drug+Administration%27s+adverse+event+reporting+system%3A+an+overview+of+reports%2C+2003-2007.&rft.au=Johann-Liang%2C+Rosemary%3BWyeth%2C+Jo%3BChen%2C+Min%3BCope%2C+Judith+U&rft.aulast=Johann-Liang&rft.aufirst=Rosemary&rft.date=2009-01-01&rft.volume=18&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+drug+safety&rft.issn=1099-1557&rft_id=info:doi/10.1002%2Fpds.1679 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-02 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pds.1679 ER - TY - JOUR T1 - Frontiers in addiction research: celebrating the 35th anniversary of the National Institute on Drug Abuse. Sponsor's foreword. AN - 66801377; 18789343 JF - Neuropharmacology AU - Shurtleff, David AU - Liu, Rita AU - Sasek, Cathrine AD - National Institute on Drug Abuse, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA. dshurtle@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 1 EP - 2 VL - 56 Suppl 1 SN - 0028-3908, 0028-3908 KW - Index Medicus KW - United States KW - Humans KW - National Institute on Drug Abuse (U.S.) KW - Biomedical Research -- trends KW - Biomedical Research -- methods KW - Substance-Related Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66801377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Frontiers+in+addiction+research%3A+celebrating+the+35th+anniversary+of+the+National+Institute+on+Drug+Abuse.+Sponsor%27s+foreword.&rft.au=Shurtleff%2C+David%3BLiu%2C+Rita%3BSasek%2C+Cathrine&rft.aulast=Shurtleff&rft.aufirst=David&rft.date=2009-01-01&rft.volume=56+Suppl+1&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/10.1016%2Fj.neuropharm.2008.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-15 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuropharm.2008.08.009 ER - TY - JOUR T1 - Telithromycin-associated hepatotoxicity: Clinical spectrum and causality assessment of 42 cases. AN - 66787949; 19085949 AB - Telithromycin is the first of a new class of ketolide antibiotics with increased activity against penicillin-resistant and erythromycin-resistant pneumococci. This agent received approval by the United States Food and Drug Administration (FDA) in 2004 for treatment of upper and lower respiratory infections. Following market introduction, spontaneous reports of telithromycin-associated hepatotoxicity, including frank liver failure, were received. To address these reports, an ad hoc group with expertise in spontaneous adverse events reporting and experience in evaluating drug-induced liver injury was formed, including members of the FDA, other federal agencies, and academia. The primary objective of this group was to adjudicate case reports of hepatic toxicity for causal attribution to telithromycin. After an initial screening of all cases of liver injury associated with telithromycin reported to FDA as of April 2006 by one of the authors, 42 cases were comprehensively reviewed and adjudicated. Five cases included a severe outcome of either death (n = 4) or liver transplantation (n = 1); more than half were considered highly likely or probable in their causal association with telithromycin. Typical clinical features were: short latency (median, 10 days) and abrupt onset of fever, abdominal pain, and jaundice, sometimes with the presence of ascites even in cases that resolved. Concurrence in assignment of causality increased after agreement on definitions of categories and interactive discussions. Telithromycin is a rare cause of drug-induced liver injury that may have a distinctive clinical signature and associated high mortality rate. Consensus for attribution of liver injury to a selected drug exposure by individual experts can be aided by careful definition of terminology and discussion. JF - Hepatology (Baltimore, Md.) AU - Brinker, Allen D AU - Wassel, Ronald T AU - Lyndly, Jenna AU - Serrano, Jose AU - Avigan, Mark AU - Lee, William M AU - Seeff, Leonard B AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. allen.brinker@fda.hhs.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 250 EP - 257 VL - 49 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - Ketolides KW - telithromycin KW - KI8H7H19WL KW - Index Medicus KW - Fatal Outcome KW - Aged, 80 and over KW - Jaundice -- chemically induced KW - Humans KW - Adult KW - Ascites -- chemically induced KW - Liver Failure -- chemically induced KW - Aged KW - Pleural Effusion -- chemically induced KW - Middle Aged KW - Male KW - Female KW - Chemical and Drug Induced Liver Injury -- etiology KW - Anti-Bacterial Agents -- adverse effects KW - Ketolides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66787949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Telithromycin-associated+hepatotoxicity%3A+Clinical+spectrum+and+causality+assessment+of+42+cases.&rft.au=Brinker%2C+Allen+D%3BWassel%2C+Ronald+T%3BLyndly%2C+Jenna%3BSerrano%2C+Jose%3BAvigan%2C+Mark%3BLee%2C+William+M%3BSeeff%2C+Leonard+B&rft.aulast=Brinker&rft.aufirst=Allen&rft.date=2009-01-01&rft.volume=49&rft.issue=1&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.22620 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-30 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/hep.22620 ER - TY - JOUR T1 - Ventral tegmental glutamate: a role in stress-, cue-, and cocaine-induced reinstatement of cocaine-seeking. AN - 66787498; 18598707 AB - Ventral tegmental dopamine neurons are activated by primary rewards and, when such rewards are predictable' by reward-predicting stimuli. Glutamatergic input to the ventral tegmental area contributes to this activation: in animals trained to self-administer cocaine, cocaine-predictive cues trigger ventral tegmental glutamate release and dopaminergic activation. Mild footshock stress similarly causes glutamate release and dopaminergic activation in cocaine-trained but not cocaine-naïve animals. The ability of cocaine-predictive and stress-associated cues to activate the dopamine system and to trigger cocaine craving appears to be related to changes in the ability of glutamate to activate dopaminergic neurons, changes known to be caused by experience with stress or with drugs of abuse. JF - Neuropharmacology AU - Wise, Roy A AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes on Health, Department of Health and Human Services, 251 Bayview Blvd., Baltimore, MD 21224, USA. rwise@intra.nida.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 174 EP - 176 VL - 56 Suppl 1 SN - 0028-3908, 0028-3908 KW - Glutamic Acid KW - 3KX376GY7L KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Humans KW - Cocaine -- administration & dosage KW - Glutamic Acid -- metabolism KW - Cocaine-Related Disorders -- pathology KW - Cocaine-Related Disorders -- psychology KW - Cues KW - Ventral Tegmental Area -- metabolism KW - Cocaine-Related Disorders -- etiology KW - Ventral Tegmental Area -- drug effects KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66787498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Ventral+tegmental+glutamate%3A+a+role+in+stress-%2C+cue-%2C+and+cocaine-induced+reinstatement+of+cocaine-seeking.&rft.au=Wise%2C+Roy+A&rft.aulast=Wise&rft.aufirst=Roy&rft.date=2009-01-01&rft.volume=56+Suppl+1&rft.issue=&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/10.1016%2Fj.neuropharm.2008.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-15 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1983 Aug 19;221(4612):773-5 [6879176] Can J Psychol. 1977 Dec;31(4):195-203 [608135] Psychopharmacology (Berl). 1984;84(2):167-73 [6438676] J Chem Neuroanat. 1989 Sep-Oct;2(5):285-98 [2572241] Pharmacol Biochem Behav. 1989 Dec;34(4):899-904 [2623043] J Comp Neurol. 1992 Jun 8;320(2):145-60 [1377716] Neuroscience. 1994 Aug;61(4):851-65 [7530817] J Neurochem. 1995 Sep;65(3):1407-10 [7643120] Psychopharmacology (Berl). 1995 Jul;120(1):10-20 [7480530] Psychopharmacology (Berl). 1995 Nov;122(2):194-7 [8848536] Science. 1997 Mar 14;275(5306):1593-9 [9054347] J Neurochem. 1998 Apr;70(4):1497-502 [9523566] J Neurochem. 1998 Apr;70(4):1503-12 [9523567] J Neurophysiol. 1998 Jul;80(1):1-27 [9658025] J Neurosci. 1998 Aug 15;18(16):6492-500 [9698337] Synapse. 1999 Mar 15;31(4):241-9 [10051104] J Neurosci. 2005 May 11;25(19):4725-32 [15888648] J Neurosci. 2005 Jun 1;25(22):5389-96 [15930388] Eur J Neurosci. 2007 Jan;25(1):106-18 [17241272] Neuroscience. 2007 May 25;146(3):1259-74 [17391856] J Neurosci. 2007 May 23;27(21):5730-43 [17522317] Psychopharmacology (Berl). 2007 Aug;193(2):283-94 [17437087] J Neurosci. 2007 Sep 26;27(39):10546-55 [17898226] J Comp Neurol. 2008 Feb 1;506(4):616-26 [18067140] J Comp Neurol. 2008 Jul 20;509(3):302-18 [18478589] J Neurosci. 2000 Feb 15;20(4):1635-42 [10662853] J Comp Neurol. 2000 Dec 11;428(2):191-212 [11064361] Neuroscience. 2000;101(1):115-29 [11068141] Eur J Neurosci. 2001 Feb;13(4):819-28 [11207817] Nature. 2001 May 31;411(6837):583-7 [11385572] J Endocrinol. 2002 Oct;175(1):89-97 [12379493] Neuron. 2003 Feb 20;37(4):577-82 [12597856] J Comp Neurol. 2003 Apr 28;459(2):142-55 [12640666] Neuron. 2003 Jul 31;39(3):401-7 [12895416] J Neurosci. 2003 Oct 15;23(28):9305-11 [14561857] Curr Opin Pharmacol. 2004 Feb;4(1):23-9 [15018835] Nat Rev Neurosci. 2004 Jun;5(6):483-94 [15152198] Science. 1975 Feb 14;187(4176):547-9 [1114313] Pavlov J Biol Sci. 1976 Oct-Dec;11(4):222-36 [1033507] Pharmacol Biochem Behav. 1977 Jun;6(6):615-20 [122445] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuropharm.2008.06.008 ER - TY - JOUR T1 - The US and EU regulatory perspectives on the clinical use of hematopoietic stem/progenitor cells genetically modified ex vivo by retroviral vectors. AN - 66769917; 19110646 AB - A primary safety issue presented by human hematopoietic stem cells/progenitor cells (HS/PC) genetically modified by gammaretroviral or lentiviral vectors is the risk of oncogenesis. This risk is a potential consequence of either of the following events: (a) the possible unintended generation of replication-competent vector-derived viruses (replication-competent retrovirus, RCR; replication-competent lentivirus, RCL) leading to neoplasia due to RCR/RCL infection of target and nontarget cells in vivo, or (b) intended vector integration in the chromosomal DNA of the target somatic cells leading to neoplasia due to insertional mutagenesis. These risks should be addressed in nonclinical and clinical studies. In the US and the EU, a combination of regulations and guidance documents are available to investigators and sponsors of gene therapy clinical trials. Guidance documents provide a facile way to adapt regulatory recommendations, in line with the changing state of the art in medical science. In the field of retroviral vectors, a number of innovations are being tested in nonclinical or clinical investigations, and each of these will raise their own regulatory issues. Some recent examples of these types of innovations include development of novel vector structures to minimize risks associated with vector integration, such as lentiviral vectors currently used in clinical trials for HS/PC modification that have been designed with deletions of the strong retroviral enhancer associated with oncogenesis. JF - Methods in molecular biology (Clifton, N.J.) AU - Wilson, Carolyn A AU - Cichutek, Klaus AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, U.S. FDA, Bethesda, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 477 EP - 488 VL - 506 SN - 1064-3745, 1064-3745 KW - Index Medicus KW - United States KW - European Union KW - Humans KW - Jurisprudence KW - Genetic Vectors KW - Hematopoietic Stem Cells -- cytology KW - Retroviridae -- genetics KW - Hematopoietic Stem Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66769917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=The+US+and+EU+regulatory+perspectives+on+the+clinical+use+of+hematopoietic+stem%2Fprogenitor+cells+genetically+modified+ex+vivo+by+retroviral+vectors.&rft.au=Wilson%2C+Carolyn+A%3BCichutek%2C+Klaus&rft.aulast=Wilson&rft.aufirst=Carolyn&rft.date=2009-01-01&rft.volume=506&rft.issue=&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-409-4_32 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-24 N1 - Date created - 2008-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-409-4_32 ER - TY - JOUR T1 - Increased frequency of chromosome translocations in airline pilots with long-term flying experience. AN - 66749323; 19074211 AB - Chromosome translocations are an established biomarker of cumulative exposure to external ionising radiation. Airline pilots are exposed to cosmic ionising radiation, but few flight crew studies have examined translocations in relation to flight experience. We determined the frequency of translocations in the peripheral blood lymphocytes of 83 airline pilots and 50 comparison subjects (mean age 47 and 46 years, respectively). Translocations were scored in an average of 1039 cell equivalents (CE) per subject using fluorescence in situ hybridisation (FISH) whole chromosome painting and expressed per 100 CE. Negative binomial regression models were used to assess the relationship between translocation frequency and exposure status and flight years, adjusting for age, diagnostic x ray procedures, and military flying. There was no significant difference in the adjusted mean translocation frequency of pilots and comparison subjects (0.37 (SE 0.04) vs 0.38 (SE 0.06) translocations/100 CE, respectively). However, among pilots, the adjusted translocation frequency was significantly associated with flight years (p = 0.01) with rate ratios of 1.06 (95% CI 1.01 to 1.11) and 1.81 (95% CI 1.16 to 2.82) for a 1- and 10-year incremental increase in flight years, respectively. The adjusted rate ratio for pilots in the highest compared to the lowest quartile of flight years was 2.59 (95% CI 1.26 to 5.33). Our data suggests that pilots with long-term flying experience may be exposed to biologically significant doses of ionising radiation. Epidemiological studies with longer follow-up of larger cohorts of pilots with a wide range of radiation exposure levels are needed to clarify the relationship between cosmic radiation exposure and cancer risk. JF - Occupational and environmental medicine AU - Yong, L C AU - Sigurdson, A J AU - Ward, E M AU - Waters, M A AU - Whelan, E A AU - Petersen, M R AU - Bhatti, P AU - Ramsey, M J AU - Ron, E AU - Tucker, J D AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226, USA. LAY7@CDC.GOV Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 56 EP - 62 VL - 66 IS - 1 KW - Index Medicus KW - Radiation Dosage KW - Humans KW - Adult KW - In Situ Hybridization, Fluorescence KW - Occupational Exposure -- adverse effects KW - Middle Aged KW - Time Factors KW - Occupational Exposure -- analysis KW - Male KW - Occupational Diseases -- genetics KW - Aircraft KW - Occupational Diseases -- etiology KW - Aerospace Medicine KW - Occupational Diseases -- epidemiology KW - Translocation, Genetic KW - Cosmic Radiation -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66749323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Increased+frequency+of+chromosome+translocations+in+airline+pilots+with+long-term+flying+experience.&rft.au=Yong%2C+L+C%3BSigurdson%2C+A+J%3BWard%2C+E+M%3BWaters%2C+M+A%3BWhelan%2C+E+A%3BPetersen%2C+M+R%3BBhatti%2C+P%3BRamsey%2C+M+J%3BRon%2C+E%3BTucker%2C+J+D&rft.aulast=Yong&rft.aufirst=L&rft.date=2009-01-01&rft.volume=66&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foem.2008.038901 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-02 N1 - Date created - 2008-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Aviat Space Environ Med. 1989 Nov;60(11):1104-8 [2818404] Health Phys. 2000 Nov;79(5):526-44 [11045526] Int J Radiat Biol. 1992 Jul;62(1):53-63 [1353776] Naturwissenschaften. 1993 Nov;80(11):528-30 [8264808] Environ Health Perspect. 1993 Oct;101 Suppl 3:225-9 [8143622] Mutat Res. 1994 Nov 1;311(1):39-48 [7526173] Cytogenet Cell Genet. 1995;68(3-4):211-21 [7842739] Mutat Res. 1995 Oct;338(1-6):95-106 [7565886] Mutat Res. 1996 Sep;365(1-3):147-59 [8898995] Int J Radiat Biol. 1996 Dec;70(6):647-56 [8980661] Mutat Res. 1997 Jun 9;377(1):89-93 [9219583] Health Phys. 2000 Nov;79(5):576-84 [11045533] Radiat Environ Biophys. 2000 Dec;39(4):227-31 [11200966] Int J Radiat Biol. 2001 Aug;77(8):901-8 [11571024] Mutat Res. 2002 Jan 15;513(1-2):11-5 [11719085] Occup Med. 2002 Apr-Jun;17(2):293-309, v [11872442] Radiat Res. 2002 Oct;158(4):424-42 [12236810] Health Phys. 2003 Feb;84(2):245-59 [12553655] Aviat Space Environ Med. 2003 Sep;74(9):953-6 [14503673] Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7474-6 [1881886] Radiat Res. 1997 Sep;148(3):216-26 [9291352] Radiat Res. 1998 Jun;149(6):602-13 [9611099] Aviat Space Environ Med. 1998 Jul;69(7):621-5 [9681366] Environ Mol Mutagen. 1998;32(2):121-9 [9776174] Environ Mol Mutagen. 1999;33(2):94-110 [10217064] Radiat Res. 1999 Jul;152(1):1-5 [10381835] Int J Radiat Biol. 1999 Jul;75(7):829-36 [10489894] Cancer Invest. 2004;22(5):743-61 [15581056] Toxicol Ind Health. 2005 Nov;21(10):273-82 [16463960] Mutat Res. 2006 Aug 30;600(1-2):37-45 [16814813] Radiat Res. 2007 Jun;167(6):727-34 [17523852] Mutat Res. 2000 May 8;467(2):169-76 [10838204] J Immunol Methods. 1981;43(3):349-50 [7019347] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/oem.2008.038901 ER - TY - JOUR T1 - Measurement capability of field portable organic vapor monitoring instruments under different experimental conditions. AN - 66719294; 18949604 AB - The performance of field portable direct-reading organic vapor monitors (DROVMs) was evaluated under a variety of experimental conditions. Four of the DROVMs had photoionization detectors (ppbRAE, IAQRAE, MultiRAE, and Century Toxic Vapor Analyzer), one had a flame ionization detector (Century Toxic Vapor Analyzer), and one was a single-beam infrared spectrophotometer (SapphIRe). Four of each DROVM (two Century Toxic Vapor Analyzers and SapphIRes) were tested. The DROVMs were evaluated at three temperatures (4 degrees C, 21 degrees C, and 38 degrees C), three relative humidities (30%, 60%, and 90%), and two hexane concentrations (5 ppm and 100 ppm). These conditions were selected to provide a range within the operational parameters of all the instruments. At least four replicate trials were performed across the 18 experimental conditions (3 temperatures x 3 relative humidities x 2 concentrations). To evaluate performance, the 4-hr time-weighted average readings from the DROVMs in a given trial were compared with the average of two charcoal tube concentrations using pairwise comparison. The pairwise comparison criterion was +/-25% measurement agreement between each individual DROVM and the DROVMs as a group and the average charcoal tube concentration. The ppbRAE group performed the best with 40% of all readings meeting the comparison criterion followed by the SapphIRe group at 39%. Among individual DROVMs, the best performer was a SapphIRe, with 57% of its readings meeting the criterion. The data was further analyzed by temperature, humidity, and concentration. The results indicated the performance of some DROVMs may be affected by temperature, humidity, and/or concentration. The ppbRAE group performed best at 21 degrees C with the percentage of readings meeting the criterion increasing to 63%. At the 5 ppm concentration, 44% of the ppbRAE group readings met the criterion, while at 100 ppm, only 35% did. The results indicate that monitors can be used as survey tools. Based on the data, the inconsistent performance of these DROVMs may not allow them to be used for determining compliance with occupational exposure limits. JF - Journal of occupational and environmental hygiene AU - Coffey, Christopher C AU - Pearce, Terri A AU - Lawrence, Robert B AU - Hudnall, Judith B AU - Slaven, James E AU - Martin, Stephen B AD - Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888, USA. ccoffey@cdc.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 1 EP - 8 VL - 6 IS - 1 KW - Air Pollutants KW - 0 KW - Hexanes KW - Charcoal KW - 16291-96-6 KW - Index Medicus KW - Hexanes -- analysis KW - Temperature KW - Humidity KW - Calibration KW - Air Pollutants -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66719294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Measurement+capability+of+field+portable+organic+vapor+monitoring+instruments+under+different+experimental+conditions.&rft.au=Coffey%2C+Christopher+C%3BPearce%2C+Terri+A%3BLawrence%2C+Robert+B%3BHudnall%2C+Judith+B%3BSlaven%2C+James+E%3BMartin%2C+Stephen+B&rft.aulast=Coffey&rft.aufirst=Christopher&rft.date=2009-01-01&rft.volume=6&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620802514728 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-11 N1 - Date created - 2008-10-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Occup Environ Hyg. 2009 Jun;6(6):D25-6; author reply D26 [19288334] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620802514728 ER - TY - JOUR T1 - Evaluation of the signalling and referral system for households at risk of eviction in Amsterdam AN - 61362903; 201000124 AB - In Amsterdam, over 1400 households are evicted each year. We describe the results of an evaluation of the functioning of the signalling and referral system, set up for households at risk of eviction, through a qualitative and quantitative study. Interviews and questionnaires completed by employees of 12 housing associations (for rent arrears) and by employees of 13 nuisance control care networks (for nuisance), were used. Data on households with rent arrears, for which a court eviction order was requested, were collected prospectively in September and October 2003, and retrospectively on households causing nuisance and/or who were known to be evicted due to nuisance in 2001 -2003. Functioning of signalling, of the 'alarm' of problems underlying rent arrears and/or nuisance, was evaluated by the extent of problems that were identified by the employees. Functioning of referral was evaluated by comparing the identified problems with the assistance contacts. For 275 households with rent arrears, housing associations reported social problems in 196 (71%), of whom 94 (48%) were in contact with social assistance, and medical problems in 62 (23%) of whom 18 (29%) were in contact with medical assistance. House visits resulted in a much higher identification of problems, and were associated with a reduced eviction risk [relative risk 0.57 (95% confidence interval: 0.43 -0.75)]. For 190 nuisance households, nuisance control care networks reported social problems in 103 (54%), of which 13 (13%) were in contact with social assistance, and medical problems in 155 (82%), of which 142 (92%) were in contact with medical assistance. To prevent evictions in Amsterdam, housing associations should improve their signalling role by conducting more house visits, and they should refer more households to medical assistance. Nuisance control care networks should refer more households to social assistance. Only a systematic and integrated approach can keep more households at home. Accepted for publication 20 March 2008. Adapted from the source document. JF - Health & Social Care in the Community AU - van Laere, Igor AU - de Wit, Matty AU - Klazinga, Niek AD - GGD Municipal Public Health Service, Amsterdam, the Netherlands and Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 1 EP - 8 PB - Blackwell Publishing, Oxford UK VL - 17 IS - 1 SN - 0966-0410, 0966-0410 KW - Evaluation KW - Risk KW - Quality of Health Care KW - Households KW - Amsterdam, Netherlands KW - Health Care Services KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61362903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+%26+Social+Care+in+the+Community&rft.atitle=Evaluation+of+the+signalling+and+referral+system+for+households+at+risk+of+eviction+in+Amsterdam&rft.au=van+Laere%2C+Igor%3Bde+Wit%2C+Matty%3BKlazinga%2C+Niek&rft.aulast=van+Laere&rft.aufirst=Igor&rft.date=2009-01-01&rft.volume=17&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Health+%26+Social+Care+in+the+Community&rft.issn=09660410&rft_id=info:doi/10.1111%2Fj.1365-2524.2007.00790.x LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - HSCCEL N1 - SubjectsTermNotLitGenreText - Evaluation; Health Care Services; Households; Risk; Amsterdam, Netherlands; Quality of Health Care DO - http://dx.doi.org/10.1111/j.1365-2524.2007.00790.x ER - TY - JOUR T1 - Cost Sharing In Medicaid And CHIP: How Does It Affect Out-Of-Pocket Spending? Although increased cost sharing can achieve budgetary savings, its potential impact on poor families needs to be carefully considered AN - 58841184; 2008-456281 AB - Rapidly rising spending has prompted debate about increasing cost sharing in Medicaid and the Children's Health Insurance Program (CHIP). In this paper we assess the role of cost sharing in Medicaid and the CHIP and its potential financial burden on low-income families with children. We find that many families would face high health spending burdens even with minimal cost sharing for their publicly insured children. Adding even modest cost sharing for such children could greatly increase high financial burdens. Our results also suggest that implementing income-based caps on family spending can help address the burden of high spending for low-income families. Adapted from the source document. JF - Health Affairs AU - Selden, Thomas M AU - Kenney, Genevieve M AU - Pantell, Matthew S AU - Ruhter, Joel AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, Rockville, Maryland tselden@ahrq.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - w607 EP - w620 PB - Project HOPE, Bethesda MD VL - 28 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Business and service sector - Insurance KW - Business and service sector - Business finance KW - Banking and public and private finance - Public finance KW - Social conditions and policy - Social policy and social development KW - United States KW - Poverty relief KW - Cost sharing KW - Family KW - Health insurance KW - Health policy KW - Child health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58841184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Cost+Sharing+In+Medicaid+And+CHIP%3A+How+Does+It+Affect+Out-Of-Pocket+Spending%3F+Although+increased+cost+sharing+can+achieve+budgetary+savings%2C+its+potential+impact+on+poor+families+needs+to+be+carefully+considered&rft.au=Selden%2C+Thomas+M%3BKenney%2C+Genevieve+M%3BPantell%2C+Matthew+S%3BRuhter%2C+Joel&rft.aulast=Selden&rft.aufirst=Thomas&rft.date=2009-01-01&rft.volume=28&rft.issue=&rft.spage=w607&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.28.4.w607 LA - English DB - PAIS Index N1 - Date revised - 2010-03-05 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Child health; Health insurance; Cost sharing; Family; Poverty relief; United States; Health policy DO - http://dx.doi.org/10.1377/hlthaff.28.4.w607 ER - TY - JOUR T1 - Disease Management For Chronically Ill Beneficiaries In Traditional Medicare AN - 58804837; 2008-254039 AB - We summarize the Centers for Medicare and Medicaid Services' (CMS's) experience with disease management (DM) in fee-for-service Medicare. Since 1999, the CMS has conducted seven DM demonstrations involving some 300,000 beneficiaries in thirty-five programs. Programs include provider-based, third-party, and hybrid models. Reducing costs sufficient to cover program fees has proved particularly challenging. Final evaluations on twenty programs found three with evidence of quality improvement at or near budget-neutrality, net of fees. Interim monitoring covering at least twenty-one months on the remaining fifteen programs suggests that four are close to covering their fees. Characteristics of the traditional Medicare program present a challenge to these DM models. Adapted from the source document. JF - Health Affairs AU - Bott, David M AU - Kapp, Mary C AU - Johnson, Lorraine B AU - Magno, Linda M AD - Centers for Medicare and Medicaid Services (CMS), Baltimore, Maryland david.bott@cms.hhs.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 86 EP - 98 PB - Project HOPE, Bethesda MD VL - 28 IS - 1 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Diseases and disorders KW - Health conditions and policy - Health and health policy KW - Business and service sector - Business management KW - Economic conditions and policy - Economic theory KW - Cost KW - Management KW - Chronically ill KW - Medicare KW - Diseases KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58804837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Disease+Management+For+Chronically+Ill+Beneficiaries+In+Traditional+Medicare&rft.au=Bott%2C+David+M%3BKapp%2C+Mary+C%3BJohnson%2C+Lorraine+B%3BMagno%2C+Linda+M&rft.aulast=Bott&rft.aufirst=David&rft.date=2009-01-01&rft.volume=28&rft.issue=1&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.28.1.86 LA - English DB - PAIS Index N1 - Date revised - 2009-03-09 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Chronically ill; Medicare; Diseases; Management; Cost DO - http://dx.doi.org/10.1377/hlthaff.28.1.86 ER - TY - JOUR T1 - National Health Spending In 2007: Slower Drug Spending Contributes To Lowest Rate Of Overall Growth Since 1998 AN - 58795237; 2008-254049 AB - In 2007, U.S. health care spending growth slowed to its lowest rate since 1998, increasing 6.1 percent to$2.2 trillion, or$7,421 per person. The health care portion of gross domestic product reached 16.2 percent, up from 16.0 percent in 2006. Slower growth in 2007 was largely attributed to retail prescription drug spending and government administration. With the exception of prescription drugs, most other health care services grew at about the same rate as or faster than in 2006. Spending growth from private sources accelerated in 2007 as public spending slowed; however, public spending growth has continued to outpace private sources since 2002. Adapted from the source document. JF - Health Affairs AU - Hartman, Micah AU - Martin, Anne AU - McDonnell, Patricia AU - Catlin, Aaron AU - National Health Expenditure Accounts Team AD - Centers for Medicare and Medicaid Services (CMS) Office of the Actuary, Baltimore, Maryland micah.hartman@cms.hhs.gov; National Health Expenditure Accounts Team Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 246 EP - 261 PB - Project HOPE, Bethesda MD VL - 28 IS - 1 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Manufacturing and heavy industry - Pharmaceutical industry KW - Health conditions and policy - Medicine and health care KW - Prescriptions KW - Appropriations and expenditures KW - Health policy KW - Drugs KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58795237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=National+Health+Spending+In+2007%3A+Slower+Drug+Spending+Contributes+To+Lowest+Rate+Of+Overall+Growth+Since+1998&rft.au=Hartman%2C+Micah%3BMartin%2C+Anne%3BMcDonnell%2C+Patricia%3BCatlin%2C+Aaron%3BNational+Health+Expenditure+Accounts+Team&rft.aulast=Hartman&rft.aufirst=Micah&rft.date=2009-01-01&rft.volume=28&rft.issue=1&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.28.1.246 LA - English DB - PAIS Index N1 - Date revised - 2009-03-09 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Public health; Appropriations and expenditures; Health policy; Drugs; Prescriptions DO - http://dx.doi.org/10.1377/hlthaff.28.1.246 ER - TY - JOUR T1 - Concept Analysis: Malpractice and Modern-Day Nursing Practice AN - 57308081; 200917449 AB - TOPIC. The concept of malpractice can mean different things depending upon the context in which the term is used. This can lead to confusion about the standard of care required for nurses engaged in modern-day nursing practice. PURPOSE. This paper examines the attributes and characteristics of the concept of malpractice using Walker and Avant's (2005) eight-step methodology. SOURCES OF INFORMATION. CINAHL, PubMed, and PsychINFO. CONCLUSIONS. Exposure to malpractice liability is an unfortunate consequence of modern-day nursing practice. An understanding of malpractice will assist nurses in identifying situations that may expose them to legal liability and hopefully lead to improved patient care. Adapted from the source document. JF - Nursing Forum AU - Weld, Konstantine Keian AU - Bibb, Sandra C Garmon AD - Uniformed Services University of the Health Sciences, Bethesda, MD keian.weld@hhs.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 2 EP - 10 PB - Wiley-Blackwell, UK VL - 44 IS - 1 SN - 0029-6473, 0029-6473 KW - Nursing KW - Nurses KW - Professional practices KW - Liability KW - Medical malpractice KW - Patient care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57308081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Forum&rft.atitle=Concept+Analysis%3A+Malpractice+and+Modern-Day+Nursing+Practice&rft.au=Weld%2C+Konstantine+Keian%3BBibb%2C+Sandra+C+Garmon&rft.aulast=Weld&rft.aufirst=Konstantine&rft.date=2009-01-01&rft.volume=44&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Nursing+Forum&rft.issn=00296473&rft_id=info:doi/10.1111%2Fj.1744-6198.2009.00121.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical malpractice; Nursing; Professional practices; Nurses; Patient care; Liability DO - http://dx.doi.org/10.1111/j.1744-6198.2009.00121.x ER - TY - JOUR T1 - Implication of Organizational Health Policy on Organizational Attraction AN - 57277217; 200908648 AB - This study investigated both smoking and nonsmoking undergraduates' reactions to an organization implementing a policy that either mandated or recommended that employees quit smoking. Undergraduate participants (N = 296) were randomly assigned to 1 of 2 (high vs. low severity of a smoke-free policy implementation) t 2 (high vs. low organizational assistance) conditions and indicated their organizational attraction for a hypothetical organization, imagining themselves as job applicants. The findings showed that organizational attraction was affected by the level of organizational assistance but not by the level of severity. These and other findings concerning individuals' perceived severity, perceived organizational support, smoking sensitivity, and employer control are presented in detail, and the implications thereof are discussed. Adapted from the source document. JF - Health Communication AU - Dalsey, Elizabeth AU - Park, Hee Sun AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 71 EP - 81 PB - Taylor & Francis Group, Philadelphia PA VL - 24 IS - 1 SN - 1041-0236, 1041-0236 KW - Smoking KW - Organizations KW - Job applicants KW - Cessation KW - Health policy KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57277217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Implication+of+Organizational+Health+Policy+on+Organizational+Attraction&rft.au=Dalsey%2C+Elizabeth%3BPark%2C+Hee+Sun&rft.aulast=Dalsey&rft.aufirst=Elizabeth&rft.date=2009-01-01&rft.volume=24&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410230802607016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - HECOER N1 - SubjectsTermNotLitGenreText - Health policy; Organizations; Smoking; Cessation; Undergraduate students; Job applicants DO - http://dx.doi.org/10.1080/10410230802607016 ER - TY - JOUR T1 - Using Public Relations Strategies to Prompt Populations at Risk to Seek Health Information: The Hanford Community Health Project AN - 57276618; 200905036 AB - The Hanford Community Health Project (HCHP) addressed health concerns among 'downwinders' exposed to releases of radioactive iodine (I-131) from the Hanford Nuclear Reservation in the 1940s and 1950s. After developing educational materials and conducting initial outreach, HCHP had to decide whether to apply its limited resources to an advertising or public relations approach. The decision to apply public relations strategies was effective in driving awareness of the risk communication message at the community level, reinvigorating the affected community, and ultimately increasing the number of people who sought information about their risk of exposure and related health issues. HCHP used a series of communication tools to reach out to local and regional media, medical and health professionals, and community organizations. The campaign was successful in increasing the number of unique visitors to HCHP Web site and educating and activating the medical community around the releases of I-131 and patient care choices. [Reprinted by permission of Sage Publications Inc., copyright 2009.] JF - Health Promotion Practice AU - Thomas, Gregory D AU - Smith, Stephen M AU - Turcotte, Joseph A AD - Agency for Toxic Substances and Disease Registry in Seattle, Washington, and the United States Public Health Service gthomas@cdc.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 92 EP - 101 PB - Sage Publications, Thousand Oaks CA VL - 10 IS - 1 SN - 1524-8399, 1524-8399 KW - Hanford thyroid disease radioactive iodine health education downwinder community outreach public relations strategies Hanford Community Health Project HCHP risk communication health communication health information KW - Information seeking KW - Information sharing KW - Public relations KW - Health education KW - Advertising KW - Health information KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Promotion+Practice&rft.atitle=Using+Public+Relations+Strategies+to+Prompt+Populations+at+Risk+to+Seek+Health+Information%3A+The+Hanford+Community+Health+Project&rft.au=Thomas%2C+Gregory+D%3BSmith%2C+Stephen+M%3BTurcotte%2C+Joseph+A&rft.aulast=Thomas&rft.aufirst=Gregory&rft.date=2009-01-01&rft.volume=10&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Health+Promotion+Practice&rft.issn=15248399&rft_id=info:doi/10.1177%2F1524839907307676 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health information; Health education; Information seeking; Advertising; Public relations; Information sharing DO - http://dx.doi.org/10.1177/1524839907307676 ER - TY - JOUR T1 - e-Supplement: Transport and health - a five-country perspective AN - 57268120; 200903370 AB - Devolution in the UK has, inadvertently, provided a natural experiment for comparing the impact of different approaches to policy and practice on populations that are broadly similar by most criteria. Realizing the potential gold mine that this presents for comparing policy and practice in the field of public health, the UK Public Health Association has established a Devolution Strategic Interest Group to explore and capitalize on this. From the start, the Group has included the Republic of Ireland in its purview to add an extra dimension of diversity and innovation. Having previously looked at the organization of health care and public health, and at policy and practice on food, nutrition and obesity, the Group opted to look at transport and health this year. Here, the links between separate relevant policy streams are less obvious and clearly less developed than those for food, nutrition and obesity. Also, the perceived need to raise the issue up the public health agenda provides a new challenge to campaigning action for the Group. [Copyright Elsevier B.V.] JF - Public Health AU - Coyle, E AU - Huws, D AU - Monaghan, S AU - Roddy, G AU - Seery, B AU - Staats, P AU - Thunhurst, C AU - Walker, P AU - Fleming, P AD - National Public Health Service and Bridgend Local Health Board paulcrawfordwalker@googlemail.com Y1 - 2009/01// PY - 2009 DA - January 2009 SP - e21 EP - e23 PB - Elsevier Ltd, The Netherlands VL - 123 IS - 1 SN - 0033-3506, 0033-3506 KW - Devolution Transport policy Inequalities in health Cheap bus fares Active travel Health impact assessment Road traffic accidents KW - Obesity KW - Public transport KW - Transport KW - UK KW - Devolution KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57268120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health&rft.atitle=e-Supplement%3A+Transport+and+health+-+a+five-country+perspective&rft.au=Coyle%2C+E%3BHuws%2C+D%3BMonaghan%2C+S%3BRoddy%2C+G%3BSeery%2C+B%3BStaats%2C+P%3BThunhurst%2C+C%3BWalker%2C+P%3BFleming%2C+P&rft.aulast=Coyle&rft.aufirst=E&rft.date=2009-01-01&rft.volume=123&rft.issue=1&rft.spage=e21&rft.isbn=&rft.btitle=&rft.title=Public+Health&rft.issn=00333506&rft_id=info:doi/10.1016%2Fj.puhe.2008.10.023 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Devolution; Public transport; Public health; Obesity; Transport; UK DO - http://dx.doi.org/10.1016/j.puhe.2008.10.023 ER - TY - JOUR T1 - Microseismic monitoring at a limestone mine AN - 50133535; 2009-097495 JF - Geotechnical and Geological Engineering AU - Ge, M AU - Mrugala, M AU - Iannacchione, A T Y1 - 2009 PY - 2009 DA - 2009 SP - 325 EP - 339 PB - Springer, Dordrecht VL - 27 IS - 3 SN - 0960-3182, 0960-3182 KW - United States KW - mining KW - failures KW - monitoring KW - geologic hazards KW - underground mining KW - Connellsville Pennsylvania KW - optimization KW - rock mechanics KW - fractures KW - Springfield Pike Mine KW - safety KW - rock bursts KW - mining geology KW - microseisms KW - Pennsylvania KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50133535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geotechnical+and+Geological+Engineering&rft.atitle=Microseismic+monitoring+at+a+limestone+mine&rft.au=Ge%2C+M%3BMrugala%2C+M%3BIannacchione%2C+A+T&rft.aulast=Ge&rft.aufirst=M&rft.date=2009-01-01&rft.volume=27&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Geotechnical+and+Geological+Engineering&rft.issn=09603182&rft_id=info:doi/10.1007%2Fs107006-008-9234-z L2 - http://www.springerlink.com/app/home/journal.asp?wasp=f656ca91cf3b40e8868983de406060e5&referrer=parent&backto=linkingpublicationresults,1:100171,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - Number of references - 15 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Connellsville Pennsylvania; failures; fractures; geologic hazards; microseisms; mining; mining geology; monitoring; optimization; Pennsylvania; rock bursts; rock mechanics; safety; Springfield Pike Mine; underground mining; United States DO - http://dx.doi.org/10.1007/s107006-008-9234-z ER - TY - JOUR T1 - Modeling of coal bed methane (CBM) production and CO (sub 2) sequestration in coal seams AN - 50106929; 2010-012099 AB - A mathematical model was developed to predict the coal bed methane (CBM) production and carbon dioxide (CO (sub 2) ) sequestration in a coal seam accounting for the coal seam properties. The model predictions showed that, for a CBM production and dewatering process, the pressure could be reduced from 15.17 MPa to 1.56 MPa and the gas saturation increased up to 50% in 30 years for a 5.4 x 10 (super 5) m (super 2) of coal formation. For the CO (sub 2) sequestration process, the model prediction showed that the CO (sub 2) injection rate was first reduced and then slightly recovered over 3 to 13 years of injection, which was also evidenced by the actual in seam data. The model predictions indicated that the sweeping of the water in front of the CO (sub 2) flood in the cleat porosity could be important on the loss of injectivity. Further model predictions suggested that the injection rate of CO (sub 2) could be about 11 x 10 (super 3) m (super 3) per day; the injected CO (sub 2) would reach the production well, which was separated from the injection well by 826 m, in about 30 years. During this period, about 160 x 10 (super 6) m (super 3) of CO (sub 2) could be stored within a 21.4 x 10 (super 5) m (super 2) of coal seam with a thickness of 3 m. JF - International Journal of Coal Geology AU - Ozdemir, Ekrem A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 145 EP - 152 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - methane KW - carbon sequestration KW - pressure KW - numerical models KW - natural gas KW - aliphatic hydrocarbons KW - petroleum KW - mathematical models KW - coal seams KW - alkanes KW - gases KW - carbon dioxide KW - models KW - gas injection KW - organic compounds KW - sedimentary rocks KW - saturation KW - coal KW - hydrocarbons KW - coalbed methane KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50106929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Modeling+of+coal+bed+methane+%28CBM%29+production+and+CO+%28sub+2%29+sequestration+in+coal+seams&rft.au=Ozdemir%2C+Ekrem&rft.aulast=Ozdemir&rft.aufirst=Ekrem&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; carbon dioxide; carbon sequestration; coal; coal seams; coalbed methane; gas injection; gases; hydrocarbons; mathematical models; methane; models; natural gas; numerical models; organic compounds; petroleum; pressure; saturation; sedimentary rocks DO - http://dx.doi.org/10.1016/j.coal.2008.09.003 ER - TY - JOUR T1 - An improved permeability model of coal for coalbed methane recovery and CO (sub 2) geosequestration AN - 50106867; 2010-012097 AB - An alternative approach is proposed to develop an improved permeability model for coalbed methane (CBM) and CO (sub 2) -enhanced CBM (ECBM) recovery, and CO (sub 2) geosequestration in coal. This approach integrates the textural and mechanical properties to describe the anisotropy of gas permeability in coal reservoirs. The model accounts for the stress dependent deformation using a stress-strain correlation, which allows determination of directional permeability for coals. The stress-strain correlation was developed by combining mechanical strain with sorption-induced strain for any given direction. The mechanical strain of coal is described by the general thermo-poro-elastic constitutive equations for solid materials under isothermal conditions and the sorption-induced strain is approximated by treating the swelling/shrinkage of coal matrix equivalent to the thermal contraction/expansion of materials. With directional strains, the permeability of coal in any given direction can be modeled based on the theory of rock hydraulics. In this study, the proposed model was tested with both literature data and experiments. The experiments were carried out using a specially designed true tri-axial stress coal permeameter (TTSCP). The results show that the proposed model provides better predictions for the literature data compared with other conventional coal permeability models. The model also gives reasonable agreement between the predicted and measured stress-strains and directional permeabilities under laboratory conditions. JF - International Journal of Coal Geology AU - Wang, G X AU - Massarotto, P AU - Rudolph, V A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 127 EP - 136 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - permeameters KW - experimental studies KW - elasticity KW - carbon sequestration KW - strain KW - natural gas KW - poroelasticity KW - stress KW - petroleum KW - enhanced recovery KW - recovery KW - porosity KW - carbon dioxide KW - models KW - laboratory studies KW - sedimentary rocks KW - coal KW - coalbed methane KW - permeability KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50106867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=An+improved+permeability+model+of+coal+for+coalbed+methane+recovery+and+CO+%28sub+2%29+geosequestration&rft.au=Wang%2C+G+X%3BMassarotto%2C+P%3BRudolph%2C+V&rft.aulast=Wang&rft.aufirst=G&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.10.007 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; carbon sequestration; coal; coalbed methane; elasticity; enhanced recovery; experimental studies; laboratory studies; models; natural gas; permeability; permeameters; petroleum; poroelasticity; porosity; recovery; sedimentary rocks; strain; stress DO - http://dx.doi.org/10.1016/j.coal.2008.10.007 ER - TY - JOUR T1 - Assessment of shrinkage-swelling influences in coal seams using rank-dependent physical coal properties AN - 50106686; 2010-012104 AB - Characterization of coal reservoirs and determination of in-situ physical coal properties related to transport mechanism are complicated due to having lack of standard procedures in the literature. By considering these difficulties, a new approach has been developed proposing the usage of relationships between coal rank and physical coal properties. In this study, effects of shrinkage and swelling (SS) on total methane recovery at CO (sub 2) breakthrough (TMRB), which includes ten-year primary methane recovery and succeeding enhanced coalbed methane (ECBM) recovery up to CO (sub 2) breakthrough, and CO (sub 2) sequestration have been investigated by using rank-dependent coal properties. In addition to coal rank, different coal reservoir types, molar compositions of injected fluid, and parameters within the extended Palmer & Mansoori (P&M) permeability model were considered. As a result of this study, shrinkage and swelling lead to an increase in TMRB. Moreover, swelling increased CO (sub 2) breakthrough time and decreased displacement ratio and CO (sub 2) storage for all ranks of coal. Low-rank coals are affected more negatively than high-rank coals by swelling. Furthermore, it was realized that dry coal reservoirs are more influenced by swelling than others and saturated wet coals are more suitable for eliminating the negative effects of CO (sub 2) injection. In addition, it was understood that it is possible to reduce swelling effect of CO (sub 2) on cleat permeability by mixing it with N (sub 2) before injection. However, an economical optimization is required for the selection of proper gas mixture. Finally, it is concluded from sensitivity analysis that elastic modulus is the most important parameter, except the initial cleat porosity, controlling SS in the extended P&M model by highly affecting TMRB. JF - International Journal of Coal Geology AU - Balan, Huseyin Onur AU - Gumrah, F A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 203 EP - 213 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - methane KW - expansion KW - carbon sequestration KW - natural gas KW - swells KW - aliphatic hydrocarbons KW - petroleum KW - enhanced recovery KW - coal seams KW - alkanes KW - porosity KW - carbon dioxide KW - compaction KW - physical properties KW - organic compounds KW - sedimentary rocks KW - coal KW - hydrocarbons KW - coalbed methane KW - permeability KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50106686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Assessment+of+shrinkage-swelling+influences+in+coal+seams+using+rank-dependent+physical+coal+properties&rft.au=Balan%2C+Huseyin+Onur%3BGumrah%2C+F&rft.aulast=Balan&rft.aufirst=Huseyin&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.014 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; carbon dioxide; carbon sequestration; coal; coal seams; coalbed methane; compaction; enhanced recovery; expansion; hydrocarbons; methane; natural gas; organic compounds; permeability; petroleum; physical properties; porosity; sedimentary rocks; swells DO - http://dx.doi.org/10.1016/j.coal.2008.09.014 ER - TY - JOUR T1 - Three-dimensional carbon dioxide-induced strain distribution within a confined bituminous coal AN - 50106637; 2010-012094 AB - Sequestration of carbon dioxide in unminable coal seams is an option to reduce carbon dioxide emissions. It is well known that the interaction of carbon dioxide with unconfined coal induces swelling. This paper contributes three-dimensional strain distribution in confined coal at microstructural level using high-resolution X-ray computerized tomography data and image analysis. Swelling and compression/compaction of regions in the coal matrix occurs with CO (sub 2) uptake. Normal strain varies between -1.15% and 0.93%, -3.11% and 0.94%, -0.43% and 0.30% along x, y and z axes respectively. Volumetric strain varies between -4.25% and 1.25%. The positive strains reported are consistent with typical range for unconstrained swelling. However, the average volumetric strains value (-0.34%) reflect overall volume reduction. Overall swelling is apparently influenced by the confining stresses. The magnitudes of normal strains are heterogeneous and anisotropic. The swelling vs. compression/compaction observed after CO (sub 2) uptake is localized and likely lithotype dependant. JF - International Journal of Coal Geology AU - Pone, J Denis N AU - Hile, Michael AU - Halleck, Phillip M AU - Mathews, Jonathan P A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 103 EP - 108 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - tomography KW - sorption KW - experimental studies KW - carbon sequestration KW - three-dimensional models KW - strain KW - swells KW - bituminous coal KW - carbon dioxide KW - compaction KW - physical properties KW - sedimentary rocks KW - computed tomography KW - coal KW - X-ray analysis KW - compression KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50106637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Three-dimensional+carbon+dioxide-induced+strain+distribution+within+a+confined+bituminous+coal&rft.au=Pone%2C+J+Denis+N%3BHile%2C+Michael%3BHalleck%2C+Phillip+M%3BMathews%2C+Jonathan+P&rft.aulast=Pone&rft.aufirst=J+Denis&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.08.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - bituminous coal; carbon dioxide; carbon sequestration; coal; compaction; compression; computed tomography; experimental studies; physical properties; sedimentary rocks; sorption; strain; swells; three-dimensional models; tomography; X-ray analysis DO - http://dx.doi.org/10.1016/j.coal.2008.08.003 ER - TY - JOUR T1 - Characterization of the CO (sub 2) fluid adsorption in coal as a function of pressure using neutron scattering techniques (SANS and USANS) AN - 50106591; 2010-012091 AB - Small angle neutron scattering techniques have been applied to investigate the phase behavior of CO (sub 2) injected into coal and possible changes in the coal pore structure that may result from this injection. Three coals were selected for this study: the Seelyville coal from the Illinois Basin (R (sub o) =0.53%), Baralaba coal from the Bowen Basin (R (sub o) =0.67%), and Bulli 4 coal from the Sydney Basin (R (sub o) =1.42%). The coals were selected from different depths to represent the range of the underground CO (sub 2) conditions (from subcritical to supercritical) which may be realized in the deep subsurface environment. The experiments were conducted in a high pressure cell and CO (sub 2) was injected under a range of pressure conditions, including those corresponding to in-situ hydrostatic subsurface conditions for each coal. Our experiments indicate that the porous matrix of all coals remains essentially unchanged after exposure to CO (sub 2) at pressures up to 200 bar (1 bar=10 (super 5) Pa). Each coal responds differently to the CO (sub 2) exposure and this response appears to be different in pores of various sizes within the same coal. For the Seelyville coal at reservoir conditions (16 degrees C, 50 bar), CO (sub 2) condenses from a gas into liquid, which leads to increased average fluid density in the pores (rho (sub pore) ) with sizes (r) 1 x 10 (super 5) > or = r > or = 1 x 10 (super 4) A (rho (sub pore) nearly equal 0.489 g/cm (super 3) ) as well as in small pores with size between 30 and 300 A (rho (sub pore) nearly equal 0.671 g/cm (super 3) ). These values are by a factor of three to four higher than the density of bulk CO (sub 2) (rho (sub CO2) ) under similar thermodynamic conditions (rho (sub CO2) nearly equal 0.15 g/cm (super 3) ). At the same time, in the intermediate size pores with r nearly equal 1000 A the average fluid density is similar to the density of bulk fluid, which indicates that adsorption does not occur in these pores. At in situ conditions for the Baralaba coal (35 (super O) C, 100 bar), the average fluid density of CO (sub 2) in all pores is lower than that of the bulk fluid (rho (sub pore) /rho (sub CO2) nearly equal 0.6). Neutron scattering from the Bulli 4 coal did not show any significant variation with pressure, a phenomenon which we assign to the extremely small amount of porosity of this coal in the pore size range between 35 and 100,000 A. JF - International Journal of Coal Geology AU - Melnichenko, Y B AU - Radlinski, Andrzej P AU - Mastalerz, M AU - Cheng, G AU - Rupp, J A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 69 EP - 79 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - United States KW - Seelyville Coal Member KW - sorption KW - experimental studies KW - carbon sequestration KW - neutron methods KW - underground space KW - Bowen Basin KW - Paleozoic KW - fluid phase KW - Permian KW - porosity KW - carbon dioxide KW - Upper Permian KW - physical properties KW - sedimentary rocks KW - neutrons KW - fluid pressure KW - coal KW - Sydney Basin KW - Baralaba Coal Measures KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50106591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Characterization+of+the+CO+%28sub+2%29+fluid+adsorption+in+coal+as+a+function+of+pressure+using+neutron+scattering+techniques+%28SANS+and+USANS%29&rft.au=Melnichenko%2C+Y+B%3BRadlinski%2C+Andrzej+P%3BMastalerz%2C+M%3BCheng%2C+G%3BRupp%2C+J&rft.aulast=Melnichenko&rft.aufirst=Y&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.017 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Baralaba Coal Measures; Bowen Basin; carbon dioxide; carbon sequestration; coal; experimental studies; fluid phase; fluid pressure; neutron methods; neutrons; Paleozoic; Permian; physical properties; porosity; sedimentary rocks; Seelyville Coal Member; sorption; Sydney Basin; underground space; United States; Upper Permian DO - http://dx.doi.org/10.1016/j.coal.2008.09.017 ER - TY - JOUR T1 - Influence of carbon dioxide on coal permeability determined by pressure transient methods AN - 50105616; 2010-012095 AB - The permeability of coal samples from Pittsburgh Seam was determined using carbon dioxide as the flowing fluid. The confining pressure was varied to cover a wide range of depths. The permeability was determined as a function of exposure time of carbon dioxide while the confining stress was kept constant. The porosities of the coal samples were found to be very low and most of the samples had porosities less than 1%. The permeability of these coal samples was very low-less than 1 mu D. Since the objective of this study was to investigate the influence of CO (sub 2) exposure on coal permeability, it was necessary to increase the initial permeability of the coal samples by introducing a fracture. A longitudinal fracture was induced mechanically, and CT scans were taken to ensure that the fracture was present throughout the sample and that the sample was not damaged otherwise during the process. In this study, the permeability of coal was determined by using pressure transient methods. Two types of pressure pulses were used: A-spike and Sine-6 pressure transients. It was first established that the permeability of fractured coal samples did not change with exposure time when an inert gas (Argon) was used as the fluid medium in the experiments. However, the permeability of coal samples decreased significantly when carbon dioxide was used as the fluid medium. This reduction can be attributed to the coal swelling phenomenon. The results show that the permeability reduction in fractured coal samples can be over 90% of the original value, and the exposure time for such reductions can range from 1.5 days up to a week, typically about 2 days under laboratory conditions. The permeability decreased significantly with the increase in confining pressure. The higher confining pressure appears to close internal fractures causing a reduction in permeability. JF - International Journal of Coal Geology AU - Siriwardane, Hema J AU - Haljasmaa, Igor AU - McLendon, Robert AU - Irdi, Gino AU - Soong, Y AU - Bromhal, Grant A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 109 EP - 118 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - United States KW - Pittsburgh Coal KW - experimental studies KW - expansion KW - carbon sequestration KW - pressure KW - Pennsylvanian KW - Paleozoic KW - Carboniferous KW - carbon dioxide KW - physical properties KW - sedimentary rocks KW - transient phenomena KW - coal KW - volume KW - permeability KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50105616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Influence+of+carbon+dioxide+on+coal+permeability+determined+by+pressure+transient+methods&rft.au=Siriwardane%2C+Hema+J%3BHaljasmaa%2C+Igor%3BMcLendon%2C+Robert%3BIrdi%2C+Gino%3BSoong%2C+Y%3BBromhal%2C+Grant&rft.aulast=Siriwardane&rft.aufirst=Hema&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.08.006 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; carbon sequestration; Carboniferous; coal; expansion; experimental studies; Paleozoic; Pennsylvanian; permeability; physical properties; Pittsburgh Coal; pressure; sedimentary rocks; transient phenomena; United States; volume DO - http://dx.doi.org/10.1016/j.coal.2008.08.006 ER - TY - JOUR T1 - Adsorption kinetics of CO (sub 2) , CH (sub 4) , and their equimolar mixture on coal from the Black Warrior Basin, west-central Alabama AN - 50105569; 2010-012087 AB - Laboratory experiments were conducted to investigate the adsorption kinetic behavior of pure and mixed gases (CO (sub 2) , CH (sub 4) , approximately equimolar CO (sub 2) + CH (sub 4) mixtures, and He) on a coal sample obtained from the Black Warrior Basin at the Littleton Mine (Twin Pine Coal Company), Jefferson County, west-central Alabama. The sample was from the Mary Lee coal zone of the Pottsville Formation (Lower Pennsylvanian). Experiments with three size fractions (45-150 mu m, 1-2 mm, and 5-10 mm) of crushed coal were performed at 40 degrees C and 35 degrees C over a pressure range of 1.4-6.9 MPa to simulate coalbed methane reservoir conditions in the Black Warrior Basin and provide data relevant for enhanced coalbed methane recovery operations. The following key observations were made: (1) CO (sub 2) adsorption on both dry and water-saturated coal is much more rapid than CH (sub 4) adsorption; (2) water saturation decreases the rates of CO (sub 2) and CH (sub 4) adsorption on coal surfaces, but it appears to have minimal effects on the final magnitude of CO (sub 2) or CH (sub 4) adsorption if the coal is not previously exposed to CO (sub 2) ; (3) retention of adsorbed CO (sub 2) on coal surfaces is significant even with extreme pressure cycling; and (4) adsorption is significantly faster for the 45-150 mu m size fraction compared to the two coarser fractions. JF - International Journal of Coal Geology AU - Gruszkiewicz, M S AU - Naney, M T AU - Blencoe, J G AU - Cole, D R AU - Pashin, J C AU - Carroll, R E A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 23 EP - 33 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - United States KW - methane KW - carbon sequestration KW - Pennsylvanian KW - Paleozoic KW - natural gas KW - Carboniferous KW - aliphatic hydrocarbons KW - petroleum KW - enhanced recovery KW - alkanes KW - adsorption KW - Littleton Mine KW - Alabama KW - carbon dioxide KW - Black Warrior Basin KW - physical properties KW - organic compounds KW - hydrocarbons KW - coalbed methane KW - Pottsville Group KW - kinetics KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50105569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Adsorption+kinetics+of+CO+%28sub+2%29+%2C+CH+%28sub+4%29+%2C+and+their+equimolar+mixture+on+coal+from+the+Black+Warrior+Basin%2C+west-central+Alabama&rft.au=Gruszkiewicz%2C+M+S%3BNaney%2C+M+T%3BBlencoe%2C+J+G%3BCole%2C+D+R%3BPashin%2C+J+C%3BCarroll%2C+R+E&rft.aulast=Gruszkiewicz&rft.aufirst=M&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.005 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - adsorption; Alabama; aliphatic hydrocarbons; alkanes; Black Warrior Basin; carbon dioxide; carbon sequestration; Carboniferous; coalbed methane; enhanced recovery; hydrocarbons; kinetics; Littleton Mine; methane; natural gas; organic compounds; Paleozoic; Pennsylvanian; petroleum; physical properties; Pottsville Group; United States DO - http://dx.doi.org/10.1016/j.coal.2008.09.005 ER - TY - JOUR T1 - Improving the CO (sub 2) well injectivity and enhanced coalbed methane production performance in coal seams AN - 50104748; 2010-012105 AB - This paper reports on the performance comparison for different CO (sub 2) -ECBM schemes in relatively thin unmineable seams typical of Northern Appalachian coal basin using a horizontal well configuration. Numerical simulations based upon public-domain coalbed reservoir properties indicated that injection of pure CO (sub 2) is likely to result in only limited incremental methane recovery if any over primary recovery, due to the low injection rates that can be achieved. On the other hand, the presence of the nitrogen component in the injected gas stream is capable of improving the efficiency of enhanced methane recovery significantly without compromising the net CO (sub 2) injection rates, as a result of improved injectivity over pure CO (sub 2) injection. There is, however, a trade off between incremental methane recovery and produced gas purity due to early nitrogen breakthrough. JF - International Journal of Coal Geology AU - Durucan, S AU - Shi, Ji-Quan A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 214 EP - 221 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - horizontal drilling KW - natural gas KW - Appalachians KW - petroleum KW - coal seams KW - simulation KW - production KW - nitrogen KW - carbon dioxide KW - sedimentary rocks KW - Appalachian Basin KW - coal KW - directional drilling KW - drilling KW - North America KW - carbon sequestration KW - numerical models KW - underground storage KW - enhanced recovery KW - gas injection KW - boreholes KW - underground installations KW - coalbed methane KW - Northern Appalachians KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50104748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Improving+the+CO+%28sub+2%29+well+injectivity+and+enhanced+coalbed+methane+production+performance+in+coal+seams&rft.au=Durucan%2C+S%3BShi%2C+Ji-Quan&rft.aulast=Durucan&rft.aufirst=S&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.012 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Appalachian Basin; Appalachians; boreholes; carbon dioxide; carbon sequestration; coal; coal seams; coalbed methane; directional drilling; drilling; enhanced recovery; gas injection; horizontal drilling; natural gas; nitrogen; North America; Northern Appalachians; numerical models; petroleum; production; sedimentary rocks; simulation; underground installations; underground storage DO - http://dx.doi.org/10.1016/j.coal.2008.09.012 ER - TY - JOUR T1 - Spontaneous imbibition and wettability characteristics of Powder River basin coal AN - 50104699; 2010-012088 AB - The wettability of coal is studied at scales that range from the microscopic to the core. While contact-angle measurements define wettability at microscopic (pore) and core scales, relative permeability curves define wettability and multiphase flow properties at core and reservoir scales. The microscopic wettability is evaluated based on the Frumkin-Derjaguin equation. Estimates for contact angles are made versus aqueous-phase pH. The calculations suggest a trend that goes through a maximum at a pH around 4. Contact angles become small at low and high pH suggesting an alteration of coal wettability with pH. Water imbibition studies indicate that the core-scale wetness has similar trends as those predicted for the pore scale. Contact angle goes through a maximum at a pH of around 7 and is low in highly acidic and basic solutions. X-ray computed tomography (CT) scanning based imbibition studies also provide a method of understanding multiphase flow in coal systems. Estimates for relative permeability of air-water flow in coal are obtained and reported. The results are encouraging as these are the first steps towards developing relative permeability curves for coal-methane and carbon-dioxide systems. These systems are important with regards to both CO (sub 2) sequestration as well as enhanced methane production. JF - International Journal of Coal Geology AU - Chaturvedi, T AU - Schembre, J M AU - Kovscek, A R A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 34 EP - 42 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - United States KW - carbon sequestration KW - numerical analysis KW - natural gas KW - data processing KW - petroleum KW - equations KW - cores KW - carbon dioxide KW - physical properties KW - sedimentary rocks KW - coal KW - digital simulation KW - floods KW - coalbed methane KW - X-ray analysis KW - wettability KW - controlled floods KW - computed tomography data KW - Powder River basin KW - pH KW - permeability KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50104699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Spontaneous+imbibition+and+wettability+characteristics+of+Powder+River+basin+coal&rft.au=Chaturvedi%2C+T%3BSchembre%2C+J+M%3BKovscek%2C+A+R&rft.aulast=Chaturvedi&rft.aufirst=T&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.08.002 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; carbon sequestration; coal; coalbed methane; computed tomography data; controlled floods; cores; data processing; digital simulation; equations; floods; natural gas; numerical analysis; permeability; petroleum; pH; physical properties; Powder River basin; sedimentary rocks; United States; wettability; X-ray analysis DO - http://dx.doi.org/10.1016/j.coal.2008.08.002 ER - TY - JOUR T1 - Strain development in unconfined coals exposed to CO (sub 2) , CH (sub 4) and Ar; effect of moisture AN - 50103103; 2010-012089 AB - Field experiments and laboratory studies have shown that swelling of coal takes place upon contact with carbon dioxide at underground pressure and temperature conditions. Understanding this swelling behavior is crucial for predicting the performance of future carbon dioxide sequestration operations in unminable coal seams conducted in association with methane production. Swelling is believed to be related to adsorption on the internal coal surface. Whereas it is well established that moisture influences the sorption capacity of coal, the influence of water on coal swelling is less well-defined. This paper presents the results of laboratory experiments to investigate the effect of moisture on coal swelling in the presence of carbon dioxide, methane and argon. Strain development of an unconfined sample of about 1.0-1.5 mm (super 3) at 40 degrees C and 8 MPa (and at other pressures) was observed in an optical cell under a microscope as a function of time. Both air dried and moisturized samples were used. Results confirmed different swelling behaviors of coal with different substances: carbon dioxide leads to higher strain than methane, while exposure to argon leads to very little swelling. The experiments on moisturized samples seem to confirm the role of moisture as a competitor to gas molecules for adsorption sites. Adsorption of water could also explain the observed swelling due to water uptake at atmospheric pressure. A re-introduction of carbon dioxide, after intermediate gas release, results in higher strains which indicate a drying effect of the carbon dioxide on the coal. The results of this study show that the role of water cannot be ignored if one wants to understand the fundamental processes that are taking place in enhanced coalbed methane operations. JF - International Journal of Coal Geology AU - van Bergen, F AU - Spiers, C AU - Floor, Geerke AU - Bots, Pieter A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 43 EP - 53 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - experimental studies KW - methane KW - expansion KW - strain KW - natural gas KW - moisture KW - swells KW - aliphatic hydrocarbons KW - petroleum KW - alkanes KW - carbon dioxide KW - argon KW - physical properties KW - organic compounds KW - sedimentary rocks KW - noble gases KW - coal KW - volume KW - hydrocarbons KW - coalbed methane KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50103103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Strain+development+in+unconfined+coals+exposed+to+CO+%28sub+2%29+%2C+CH+%28sub+4%29+and+Ar%3B+effect+of+moisture&rft.au=van+Bergen%2C+F%3BSpiers%2C+C%3BFloor%2C+Geerke%3BBots%2C+Pieter&rft.aulast=van+Bergen&rft.aufirst=F&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.10.003 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; argon; carbon dioxide; coal; coalbed methane; expansion; experimental studies; hydrocarbons; methane; moisture; natural gas; noble gases; organic compounds; petroleum; physical properties; sedimentary rocks; strain; swells; volume DO - http://dx.doi.org/10.1016/j.coal.2008.10.003 ER - TY - JOUR T1 - Economic analysis of carbon dioxide sequestration in Powder River basin coal AN - 50102551; 2010-012107 AB - Unmineable coalbeds are potentially large storage reservoirs for the sequestration of anthropogenic CO (sub 2) and offer the benefit of enhanced methane production, which can offset some of the costs associated with CO (sub 2) sequestration. The objective of this paper is to study the economic feasibility of CO (sub 2) sequestration in unmineable coal seams in the Powder River Basin of Wyoming. Economic analyses of CO (sub 2) injection options are compared. Results show that injecting flue gas to recover methane from CBM fields is marginally economical; however, this method will not significantly contribute to the need to sequester large quantities of CO (sub 2) . Separating CO (sub 2) from flue gas and injecting it into the unmineable coal zones of the Powder River Basin seam is currently uneconomical, but can effectively sequester over 86,000 tons (78,200 Mg) of CO (sub 2) per acre while recovering methane to offset costs. The cost to separate CO (sub 2) from flue gas was identified as the major cost driver associated with CO (sub 2) sequestration in unmineable coal seams. Improvements in separations technology alone are unlikely to drive costs low enough for CO (sub 2) sequestration in unmineable coal seams in the Powder River Basin to become economically viable. Breakthroughs in separations technology could aid the economics, but in the Powder River Basin they cannot achieve the necessary cost reductions for breakeven economics without incentives. JF - International Journal of Coal Geology AU - Robertson, Eric P A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 234 EP - 241 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - United States KW - carbon sequestration KW - natural gas KW - petroleum KW - enhanced recovery KW - coal seams KW - production KW - cost KW - evaluation KW - carbon dioxide KW - Wyoming KW - gas injection KW - sedimentary rocks KW - coal KW - coalbed methane KW - efficiency KW - Powder River basin KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50102551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Economic+analysis+of+carbon+dioxide+sequestration+in+Powder+River+basin+coal&rft.au=Robertson%2C+Eric+P&rft.aulast=Robertson&rft.aufirst=Eric&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.002 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; carbon sequestration; coal; coal seams; coalbed methane; cost; efficiency; enhanced recovery; evaluation; gas injection; natural gas; petroleum; Powder River basin; production; sedimentary rocks; United States; Wyoming DO - http://dx.doi.org/10.1016/j.coal.2008.09.002 ER - TY - JOUR T1 - Permeability changes in coal; analytical modeling AN - 50102496; 2010-012096 AB - Permeability changes can be very large during depletion of coalbed methane wells: up to 100 times in the San Juan basin. Analytic models of permeability increase during depletion are accessible, easy to use, and practical. They are more transparent, and less complicated, than coupled numerical models. However, there are minor differences between the analytic models, and these are reviewed here. There are also discrepancies in attempting to match field data, which is the final test of a model, and these are discussed. Two different sets of San Juan data have been modeled, after suppressing the pressure-dependent permeability, with reasonably consistent reservoir parameters. The matching parameters appear to be justifiable, the small porosities do not seem to be ruled out by reservoir experts, and the changes of elastic parameters (including pore-volume compressibility) with depletion do not seem unreasonable. The analytic models are used in reservoir simulators to model and predict injection of greenhouse gases in coal seams. Only when we can match the permeability increase of coalbed methane wells during depletion, will we have the confidence to use the analytic models in reservoir simulators to match or predict sequestration of greenhouse gases such as CO (sub 2) . JF - International Journal of Coal Geology AU - Palmer, Ian A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 119 EP - 126 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - United States KW - numerical analysis KW - natural gas KW - data processing KW - petroleum KW - coal seams KW - Southwestern U.S. KW - porosity KW - reservoir rocks KW - carbon dioxide KW - models KW - compaction KW - sedimentary rocks KW - coal KW - digital simulation KW - coalbed methane KW - San Juan Basin KW - greenhouse gases KW - depletion KW - permeability KW - compressibility KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50102496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Permeability+changes+in+coal%3B+analytical+modeling&rft.au=Palmer%2C+Ian&rft.aulast=Palmer&rft.aufirst=Ian&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.006 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; coal; coal seams; coalbed methane; compaction; compressibility; data processing; depletion; digital simulation; greenhouse gases; models; natural gas; numerical analysis; permeability; petroleum; porosity; reservoir rocks; San Juan Basin; sedimentary rocks; Southwestern U.S.; United States DO - http://dx.doi.org/10.1016/j.coal.2008.09.006 ER - TY - JOUR T1 - Small angle X-ray scattering mapping and kinetics study of sub-critical CO (sub 2) sorption by two Australian coals AN - 50102443; 2010-012092 AB - Time- and position-resolved synchrotron small angle X-ray scattering data were acquired from samples of two Australian coal seams: Bulli seam (Bulli 4, R (sub o) = 1.42%, Sydney Basin), which naturally contains CO (sub 2) and Baralaba seam (R (sub o) = 0.67%, Bowen Basin), a potential candidate for sequestering CO (sub 2) . This experimental approach has provided unique, pore-size-specific insights into the kinetics of CO (sub 2) sorption in the micro- and small mesopores (diameter 5 to 175 A) and the density of the sorbed CO (sub 2) at reservoir-like conditions of temperature and hydrostatic pressure. For both samples, at pressures above 5 bar, the density of CO (sub 2) confined in pores was found to be uniform, with no densification in near-wall regions. In the Bulli 4 sample, CO (sub 2) first flooded the slit pores between polyaromatic sheets. In the pore-size range analysed, the confined CO (sub 2) density was close to that of the free CO (sub 2) . The kinetics data are too noisy for reliable quantitative analysis, but qualitatively indicate faster kinetics in mineral-matter-rich regions. In the Baralaba sample, CO (sub 2) preferentially invaded the smallest micropores and the confined CO (sub 2) density was up to five times that of the free CO (sub 2) . Faster CO (sub 2) sorption kinetics was found to be correlated with higher mineral matter content but, the mineral-matter-rich regions had lower-density CO (sub 2) confined in their pores. Remarkably, the kinetics was pore-size dependent, being faster for smaller pores. These results suggest that injection into the permeable section of an interbedded coal-clastic sequence could provide a viable combination of reasonable injectivity and high sorption capacity. JF - International Journal of Coal Geology AU - Radlinski, Andrzej P AU - Busbridge, Tara L AU - Gray, Evan Mac A AU - Blach, Tomasz P AU - Cookson, David J A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 80 EP - 89 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - sorption KW - diffusion KW - carbon sequestration KW - Australasia KW - underground storage KW - Bowen Basin KW - Paleozoic KW - adsorption KW - Permian KW - Bulli Seam KW - porosity KW - size KW - carbon dioxide KW - Upper Permian KW - physical properties KW - sedimentary rocks KW - coal KW - X-ray analysis KW - Sydney Basin KW - Australia KW - Baralaba Coal Measures KW - kinetics KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50102443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Small+angle+X-ray+scattering+mapping+and+kinetics+study+of+sub-critical+CO+%28sub+2%29+sorption+by+two+Australian+coals&rft.au=Radlinski%2C+Andrzej+P%3BBusbridge%2C+Tara+L%3BGray%2C+Evan+Mac+A%3BBlach%2C+Tomasz+P%3BCookson%2C+David+J&rft.aulast=Radlinski&rft.aufirst=Andrzej&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.015 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - adsorption; Australasia; Australia; Baralaba Coal Measures; Bowen Basin; Bulli Seam; carbon dioxide; carbon sequestration; coal; diffusion; kinetics; Paleozoic; Permian; physical properties; porosity; sedimentary rocks; size; sorption; Sydney Basin; underground storage; Upper Permian; X-ray analysis DO - http://dx.doi.org/10.1016/j.coal.2008.09.015 ER - TY - JOUR T1 - Physical properties of selected block Argonne Premium bituminous coal related to CO (sub 2) , CH (sub 4) , and N (sub 2) adsorption AN - 50102404; 2010-012084 AB - CO (sub 2) , CH (sub 4) , and N (sub 2) adsorption and gas-induced swelling were quantified for block Blind Canyon, Pittsburgh #8 and Pocahontas Argonne Premium coals that were dried and structurally relaxed at 75 degrees C in vacuum. Strain measurements were made perpendicular and parallel to the bedding plane on nearly equal 7 x 7 x 7 mm (super 3) coal blocks and gravimetric sorption measurements were obtained simultaneously on companion coal blocks exposed to the same gaseous environment. The adsorption amount and strain were determined after equilibration at P N (sub 2) > CH (sub 4) ) and coals (Pocahontas > Blind Canyon > Pittsburgh #8) but not for the method of the kinetic measurement (e.g., strain or gas uptake). For Blind Canyon and Pittsburgh #8 coal, the rate of CO (sub 2) adsorption and gas-induced strain for dry coal was significantly greater than that of the corresponding native coal. For Pocahontas coal the rates of CO (sub 2) adsorption and gas-induced strain for dry and native coal were indistinguishable and may be related to its low native moisture and minimal amount of created porosity upon drying. JF - International Journal of Coal Geology AU - Kelemen, S R AU - Kwiatek, L M A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 2 EP - 9 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - United States KW - strain KW - Pennsylvanian KW - moisture KW - swells KW - aliphatic hydrocarbons KW - Pittsburgh coal basin KW - bituminous coal KW - nitrogen KW - carbon dioxide KW - absorption KW - Pocahontas Formation KW - sedimentary rocks KW - coal KW - kinetics KW - surface properties KW - methane KW - Lower Pennsylvanian KW - Blind Canyon KW - Paleozoic KW - Carboniferous KW - alkanes KW - adsorption KW - porosity KW - physical properties KW - organic compounds KW - hydrocarbons KW - Argonne Premium Coal KW - Pennsylvania KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50102404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Physical+properties+of+selected+block+Argonne+Premium+bituminous+coal+related+to+CO+%28sub+2%29+%2C+CH+%28sub+4%29+%2C+and+N+%28sub+2%29+adsorption&rft.au=Kelemen%2C+S+R%3BKwiatek%2C+L+M&rft.aulast=Kelemen&rft.aufirst=S&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.05.020 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absorption; adsorption; aliphatic hydrocarbons; alkanes; Argonne Premium Coal; bituminous coal; Blind Canyon; carbon dioxide; Carboniferous; coal; hydrocarbons; kinetics; Lower Pennsylvanian; methane; moisture; nitrogen; organic compounds; Paleozoic; Pennsylvania; Pennsylvanian; physical properties; Pittsburgh coal basin; Pocahontas Formation; porosity; sedimentary rocks; strain; surface properties; swells; United States DO - http://dx.doi.org/10.1016/j.coal.2008.05.020 ER - TY - JOUR T1 - Coupled flow and geomechanical processes during enhanced coal seam methane recovery through CO (sub 2) sequestration AN - 50101826; 2010-012106 AB - The sensitivity of coal permeability to the effective stress means that changes in stress as well as pore pressure within a coal seam lead to changes in permeability. In addition coal swells with gas adsorption and shrinks with desorption; these sorption strains impact on the coal stress state and thus the permeability. Therefore the consideration of gas migration in coal requires an appreciation of the coupled geomechanical behaviour. A number of approaches to representing coal permeability incorporate the geomechanical response and have found widespread use in reservoir simulation. However these approaches are based on two simplifying assumptions; uniaxial strain (i.e. zero strain in the horizontal plane) and constant vertical stress. This paper investigates the accuracy of these assumptions for reservoir simulation of enhanced coalbed methane through CO (sub 2) sequestration. A coupled simulation approach is used where the coalbed methane simulator SIMED II is coupled with the geomechanical model FLAC3D. This model is applied to three simulation case studies assembled from information presented in the literature. Two of these are for 100% CO (sub 2) injection, while the final example is where a flue gas (12.5% CO (sub 2) and 87.5% N (sub 2) ) is injected. It was found that the horizontal contrast in sorption strain within the coal seam caused by spatial differences in the total gas content leads to vertical stress variation. Thus the permeability calculated from the coupled simulation and that using an existing coal permeability model, the Shi-Durucan model, are significantly different; for the region in the vicinity of the production well the coupled permeability is greater than the Shi-Durucan model. In the vicinity of the injection well the permeability is less than that calculated using the Shi-Durucan model. This response is a function of the magnitude of the strain contrast within the seam and dissipates as these contrasts diminish. JF - International Journal of Coal Geology AU - Connell, L D AU - Detournay, C A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 222 EP - 233 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - sorption KW - desorption KW - carbon sequestration KW - numerical models KW - natural gas KW - data processing KW - petroleum KW - enhanced recovery KW - coal seams KW - rock mechanics KW - reservoir rocks KW - gases KW - carbon dioxide KW - gas injection KW - sedimentary rocks KW - coal KW - digital simulation KW - coalbed methane KW - permeability KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50101826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Coupled+flow+and+geomechanical+processes+during+enhanced+coal+seam+methane+recovery+through+CO+%28sub+2%29+sequestration&rft.au=Connell%2C+L+D%3BDetournay%2C+C&rft.aulast=Connell&rft.aufirst=L&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.013 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; carbon sequestration; coal; coal seams; coalbed methane; data processing; desorption; digital simulation; enhanced recovery; gas injection; gases; natural gas; numerical models; permeability; petroleum; reservoir rocks; rock mechanics; sedimentary rocks; sorption DO - http://dx.doi.org/10.1016/j.coal.2008.09.013 ER - TY - JOUR T1 - Production of gas from coal seams in the Upper Silesian coal basin in Poland in the post-injection period of an ECBM pilot site AN - 50101791; 2010-012102 AB - A pilot site for CO (sub 2) storage in coal seams was set-up in the Upper Silesian Coal Basin in Poland in the scope of the RECOPOL project, funded by the European Commission. About 760 tons CO (sub 2) were injected into the reservoir from August 2004 to June 2005. Breakthrough of the injected CO (sub 2) was established, which resulted in the production of about 10% of the injected CO (sub 2) in this period. This paper reports on activities performed under the European Commission project MOVECBM that aimed at the assessment of the storage performance of the reservoir in the follow-up period, i.e. whether the injected CO (sub 2) was adsorbed onto the coal or whether it was still present as free gas in the pore space. The injection well was used for this purpose, as the production well had to be abandoned for permitting reasons. Several operational periods can be defined between the last injection in June 2005 and the abandonment of the well in October 2007. In the first period the well was shut-in to observe the pressure fall-off, from about 15.0 MPa at the wellhead after the last injection until about 4.5 MPa at the end of 2005. This pressure fall-off curve showed that the reservoir permeability was very low. This seemed to confirm the observed swelling of the coal during the injection period. In the first months of 2006 the pressure at the wellhead was decreased by releasing gas in a controlled way. The amount and composition of the gas were measured. As a result of the pressure reduction, the well flooded with water. A production pump was placed on the former injection well, enabling active production from the coal from March to September 2007. Results of these operations showed that whereas the gas production rates were as expected based on the experience with the production well, the water production was remarkably low. This could be related to permeability issues or, alternatively, indicate a drying effect of the CO (sub 2) in the reservoir. Further, the gas composition showed a predominance of CO (sub 2) over CH (sub 4) during the gas release that changed gradually into a predominance of CH (sub 4) over CO (sub 2) during the production phase. Although stabilization was not reached within the given production period, the composition approached a 60% methane, 40% CO (sub 2) ratio. This indicates that the exchange of these gases is more complex than often envisaged. After removal of the pump the well was filled with water, which ceased the gas release. This indicates that the pressure in the reservoir was back to its original, hydrostatic, state. As the total volume of CO (sub 2) produced was only a fraction of the amount that was injected, it can be concluded that the CO (sub 2) was taken up by the coal and is currently adsorbed. This gives confidence in the long-term stability of the injected CO (sub 2) . JF - International Journal of Coal Geology AU - van Bergen, F AU - Krzystolik, Pawel AU - van Wageningen, Niels AU - Pagnier, H AU - Jura, Bartlomiej AU - Skiba, Jacek AU - Winthaegen, Pascal AU - Kobiela, Z A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 175 EP - 187 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - Upper Silesian coal basin KW - methane KW - expansion KW - pressure KW - natural gas KW - aliphatic hydrocarbons KW - petroleum KW - Europe KW - enhanced recovery KW - coal seams KW - alkanes KW - production KW - reservoir rocks KW - carbon dioxide KW - gas injection KW - organic compounds KW - Katowice Poland KW - sedimentary rocks KW - Poland KW - coal KW - Central Europe KW - hydrocarbons KW - coalbed methane KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50101791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Production+of+gas+from+coal+seams+in+the+Upper+Silesian+coal+basin+in+Poland+in+the+post-injection+period+of+an+ECBM+pilot+site&rft.au=van+Bergen%2C+F%3BKrzystolik%2C+Pawel%3Bvan+Wageningen%2C+Niels%3BPagnier%2C+H%3BJura%2C+Bartlomiej%3BSkiba%2C+Jacek%3BWinthaegen%2C+Pascal%3BKobiela%2C+Z&rft.aulast=van+Bergen&rft.aufirst=F&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.08.011 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; carbon dioxide; Central Europe; coal; coal seams; coalbed methane; enhanced recovery; Europe; expansion; gas injection; hydrocarbons; Katowice Poland; methane; natural gas; organic compounds; petroleum; Poland; pressure; production; reservoir rocks; sedimentary rocks; Upper Silesian coal basin DO - http://dx.doi.org/10.1016/j.coal.2008.08.011 ER - TY - JOUR T1 - Gas sorption and transport in coals; a poroelastic medium approach AN - 50101562; 2010-012098 AB - In this paper, single-component gas sorption and transient diffusion processes are described within coal matrix exhibiting bimodal pore structure. The coal matrix is treated as a poroelastic medium manifesting swelling and shrinkage effects due to the sorption of gas under effective overburden stress. Gas transport is considered Fickian with molecular (bulk) and surface diffusion processes simultaneously taking place in the macro- and micropores of coal, respectively. The numerical formulation is intended to be explicit in nature to investigate the influences of sorption phenomena on the macropore volumes and on the overall gas transport for the cases of gas uptake by and release from coal. Results of the study show the presence of hysteresis during a sorption-desorption cycle of the gas. It is also found that the overall gas transport takes place at a rate significantly less than that in the macropores only. Thus the existence of a retardation effect in the overall gas transport is concluded. This retardation effect is primarily due to the micropore resistances, in particular gas adsorption, and is independent of the changes in the macropore volumes. It is shown that macroporosity of the coal matrix may change during gas transport due to combined effects of pressure and sorption-induced swelling or shrinkage of the coal. It is estimated that the macroporosity variation is non-uniform in space and time, as it is expected in reality, and typically taking values less than + or -10 percent of the initial porosity. JF - International Journal of Coal Geology AU - Yi, J AU - Akkutlu, I Yucel AU - Karacan, C Ozgen AU - Clarkson, C R A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 137 EP - 144 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - sorption KW - diffusion KW - sorption hysteresis KW - expansion KW - elasticity KW - numerical analysis KW - natural gas KW - elastic properties KW - poroelasticity KW - porous materials KW - petroleum KW - porosity KW - sedimentary rocks KW - transport KW - coal KW - volume KW - coalbed methane KW - permeability KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50101562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Gas+sorption+and+transport+in+coals%3B+a+poroelastic+medium+approach&rft.au=Yi%2C+J%3BAkkutlu%2C+I+Yucel%3BKaracan%2C+C+Ozgen%3BClarkson%2C+C+R&rft.aulast=Yi&rft.aufirst=J&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.016 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - coal; coalbed methane; diffusion; elastic properties; elasticity; expansion; natural gas; numerical analysis; permeability; petroleum; poroelasticity; porosity; porous materials; sedimentary rocks; sorption; sorption hysteresis; transport; volume DO - http://dx.doi.org/10.1016/j.coal.2008.09.016 ER - TY - JOUR T1 - Modeling of ECBM recovery from Amasra coalbed in Zonguldak Basin, Turkey AN - 50101335; 2010-012101 AB - Zonguldak coal basin is the only productive hard coal basin of Turkey. The eastern part of the basin is called as Bartin-Amasra District, which has deeper coal seams. The depth and difficulty of mining these coal seams make this district an important candidate for coalbed methane (CBM) recovery. However, there is not enough reservoir data for modeling purposes. In this study, the lithologic information collected for coal mining industry was used to determine the correlations and the continuity of the coal seams. The lithologic information was examined and the depths of the coal seams and the locations of the exploration boreholes were used to perform a reliable correlation using a new method. As a result of the correlation study, 63 continuous coal layers were found. A statistical reserve estimation of each coal layer for methane was made by using Monte Carlo simulation method. The initial methane in place found in the coal layers both in free and adsorbed states were estimated using probabilistic simulations resulted in possible reserve (P10) of 2.07 billion m (super 3) , probable reserve (P50) of 1.35 billion m (super 3) and proven reserves (P90) of 0.86 billion m (super 3) . Among the determined continuous coal layers, coal layer #26 was selected for a preliminary investigation of the applicability of enhanced coalbed methane (ECBM) recovery and CO (sub 2) storage. The scarcity of coal seam reservoir data required a sensitivity study for the effects of reservoir parameters on operational performance indicators. The effects of adsorption, coal density, permeability, cleat porosity and permeability anisotropy parameters were examined using the Computer Modeling Group's (CMG) GEM module. JF - International Journal of Coal Geology AU - Sinayuc, Caglar AU - Gumrah, F A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 162 EP - 174 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - natural gas KW - Monte Carlo analysis KW - statistical analysis KW - Zonguldak Turkey KW - Turkey KW - petroleum KW - enhanced recovery KW - coal seams KW - reservoir rocks KW - carbon dioxide KW - reservoir modeling KW - sedimentary rocks KW - Amasra coal seam KW - coal KW - mathematical methods KW - coalbed methane KW - Asia KW - Middle East KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50101335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Modeling+of+ECBM+recovery+from+Amasra+coalbed+in+Zonguldak+Basin%2C+Turkey&rft.au=Sinayuc%2C+Caglar%3BGumrah%2C+F&rft.aulast=Sinayuc&rft.aufirst=Caglar&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.010 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Amasra coal seam; Asia; carbon dioxide; coal; coal seams; coalbed methane; enhanced recovery; mathematical methods; Middle East; Monte Carlo analysis; natural gas; petroleum; reservoir modeling; reservoir rocks; sedimentary rocks; statistical analysis; Turkey; Zonguldak Turkey DO - http://dx.doi.org/10.1016/j.coal.2008.09.010 ER - TY - JOUR T1 - Causes and consequences of errors in determining sorption capacity of coals for carbon dioxide at high pressure AN - 50101254; 2010-012086 AB - Recent comparisons of CO (sub 2) sorption by coals at high pressures have shown major differences between the results obtained by different laboratories. These need to be resolved for laboratory estimation of CO (sub 2) sequestration in coal seams to be useful. A compilation of potential sources of error in determination of sorption characteristics and their impact on sorption measurements is provided here. A series of tests is also provided that can be used to identify and reduce such errors in measurement. For example, an error in temperature produces a characteristic distortion of the sorption curve for carbon dioxide, which can be corrected to some extent. A negative value for excess sorption at high pressure is almost certainly diagnostic of either a cell volume that has been overestimated or that some part of the substrate that is inaccessible to the gas is accessible to helium. The major source of variation between results from the different laboratories that supplied the closest sorption values was found to be variations in the assumed free space volume, which could be due to discrepancies in determined helium density or measured cell volume. Including a term in the sorption model that is proportional to gas density will markedly reduce the influence of such errors in estimating sorption capacity or heats of sorption. The influence of swelling and moisture on sorption isotherms is also quantified here. Correction for swelling of coals in carbon dioxide changes the estimated sorption capacity by less than 1%, if a term that is proportional to gas density is included as a free parameter in the model fitting the isotherm. JF - International Journal of Coal Geology AU - Sakurovs, R AU - Day, S AU - Weir, S A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 16 EP - 22 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - sorption KW - experimental studies KW - expansion KW - carbon sequestration KW - pressure KW - adsorption KW - solubility KW - high pressure KW - porosity KW - carbon dioxide KW - physical properties KW - sedimentary rocks KW - errors KW - isotherms KW - noble gases KW - coal KW - volume KW - helium KW - pore water KW - compressibility KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50101254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Causes+and+consequences+of+errors+in+determining+sorption+capacity+of+coals+for+carbon+dioxide+at+high+pressure&rft.au=Sakurovs%2C+R%3BDay%2C+S%3BWeir%2C+S&rft.aulast=Sakurovs&rft.aufirst=R&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.07.001 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - adsorption; carbon dioxide; carbon sequestration; coal; compressibility; errors; expansion; experimental studies; helium; high pressure; isotherms; noble gases; physical properties; pore water; porosity; pressure; sedimentary rocks; solubility; sorption; volume DO - http://dx.doi.org/10.1016/j.coal.2008.07.001 ER - TY - JOUR T1 - Shrinkage and swelling of coal induced by desorption and sorption of fluids; theoretical model and interpretation of a field project AN - 50100752; 2010-012103 AB - Geologic sequestration in deep unmineable coal seams and enhanced coalbed methane production is a promising choice, economically and environmentally, to reduce anthropogenic gases such as carbon dioxide in the atmosphere. Unmineable coal seams are typically known to adsorb large amounts of carbon dioxide in comparison to the sizeable amounts of sorbed methane, which raises the potential for large scale sequestration projects. During the process of sequestration, carbon dioxide is injected into the coalbed and desorbed methane is produced. The coal matrix is believed to shrink when a gas is desorbed and swell when a gas is sorbed, sometimes causing profound changes in the cleat porosity and permeability of the coal seam. These changes may have significant impact on the reservoir performance. Therefore, it is necessary to understand the combined influence of swelling and shrinkage, and geomechanical properties including elastic modulus, cleat porosity, and permeability of the reservoir. The present paper deals with the influence of swelling and shrinkage on the reservoir performance, and the geomechanical response of the reservoir system during the process of geologic sequestration of carbon dioxide and enhanced coalbed methane production in an actual field project located in northern New Mexico. A three-dimensional swelling and shrinkage model was developed and implemented into an existing reservoir model to understand the influence of geomechanical parameters, as well as swelling and shrinkage properties, on the reservoir performance. Numerical results obtained from the modified simulator were compared to available measured values from that site and previous studies. Results show that swelling and shrinkage, and the combination of geomechanical and operational parameters, have a significant influence on the performance of the reservoir system. JF - International Journal of Coal Geology AU - Siriwardane, Hema J AU - Gondle, Raj K AU - Smith, Duane H A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 188 EP - 202 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - United States KW - sorption KW - desorption KW - expansion KW - carbon sequestration KW - numerical models KW - natural gas KW - petroleum KW - mechanical properties KW - fluid phase KW - New Mexico KW - reservoir rocks KW - gases KW - carbon dioxide KW - compaction KW - physical properties KW - sedimentary rocks KW - coal KW - coalbed methane KW - theoretical models KW - interpretation KW - field studies KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50100752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Shrinkage+and+swelling+of+coal+induced+by+desorption+and+sorption+of+fluids%3B+theoretical+model+and+interpretation+of+a+field+project&rft.au=Siriwardane%2C+Hema+J%3BGondle%2C+Raj+K%3BSmith%2C+Duane+H&rft.aulast=Siriwardane&rft.aufirst=Hema&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.08.005 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; carbon sequestration; coal; coalbed methane; compaction; desorption; expansion; field studies; fluid phase; gases; interpretation; mechanical properties; natural gas; New Mexico; numerical models; petroleum; physical properties; reservoir rocks; sedimentary rocks; sorption; theoretical models; United States DO - http://dx.doi.org/10.1016/j.coal.2008.08.005 ER - TY - JOUR T1 - Binary gas sorption/desorption experiments on a bituminous coal; simultaneous measurements on sorption kinetics, volumetric strain and acoustic emission AN - 50100728; 2010-012093 AB - There is still no clear understanding of the specific interactions between coal and gas molecules. In this context sorption-desorption studies of methane and carbon dioxide, both in a single gas environment and gas mixtures, are of fundamental interest. This paper presents the results of unique simultaneous measurements of sorption kinetics, volumetric strain and acoustic emission (AE) on three tetragonal coal samples subjected to sorption of carbon dioxide and methane mixtures. The coal was a high volatile bituminous C coal taken from the Budryk mine in the Upper Silesia Basin, Poland. Three different gas mixtures were used in the sorption tests, with dominant CO (sub 2) , with dominant CH (sub 4) and a 50/50 mixture. The experimental set-up was designed specially for this study. It consisted of three individual units working together: (i) a unit for gas sorption experiments using a volumetric method, (ii) an AE apparatus for detecting, recording and analysing AE, and (iii) a strain meter for measuring strains induced in the coal sample by gas sorption/desorption. All measurements were computer aided. The experiments indicated that the coal tested showed preferential sorption of CH (sub 4) at 2.6 MPa pressure and exhibited comparable affinities for CH (sub 4) and CO (sub 2) at higher pressures (4.0 MPa). The results of chromatographic analysis of the gas released on desorption suggested that the desorption of methane from the coal was favoured. The relationship between the volumetric strain and the amount of sorbed gas was found to be non-linear. These results were contrary to common opinions on the coal behaviour. Furthermore, it appeared that the swelling/shrinkage of coal was clearly influenced by the network of fractures. Besides, the AE and strain characteristics suggested common sources of sorption induced AE and strain. The present results may have implications for the sequestration of carbon dioxide in coal seams and enhanced coalbed methane recovery (ECBM). JF - International Journal of Coal Geology AU - Majewska, Zofia AU - Ceglarska-Stefanska, Grazyna AU - Majewski, Stanislaw AU - Zietek, Jerzy A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 90 EP - 102 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - Upper Silesian coal basin KW - sorption KW - desorption KW - Budryk Mine KW - strain KW - natural gas KW - aliphatic hydrocarbons KW - petroleum KW - Europe KW - bituminous coal KW - carbon dioxide KW - Katowice Poland KW - sedimentary rocks KW - coal KW - Central Europe KW - kinetics KW - mines KW - experimental studies KW - methane KW - carbon sequestration KW - coal mines KW - alkanes KW - measurement KW - gases KW - organic compounds KW - Poland KW - volume KW - hydrocarbons KW - coalbed methane KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50100728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Binary+gas+sorption%2Fdesorption+experiments+on+a+bituminous+coal%3B+simultaneous+measurements+on+sorption+kinetics%2C+volumetric+strain+and+acoustic+emission&rft.au=Majewska%2C+Zofia%3BCeglarska-Stefanska%2C+Grazyna%3BMajewski%2C+Stanislaw%3BZietek%2C+Jerzy&rft.aulast=Majewska&rft.aufirst=Zofia&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.09.009 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; bituminous coal; Budryk Mine; carbon dioxide; carbon sequestration; Central Europe; coal; coal mines; coalbed methane; desorption; Europe; experimental studies; gases; hydrocarbons; Katowice Poland; kinetics; measurement; methane; mines; natural gas; organic compounds; petroleum; Poland; sedimentary rocks; sorption; strain; Upper Silesian coal basin; volume DO - http://dx.doi.org/10.1016/j.coal.2008.09.009 ER - TY - JOUR T1 - Helium-volume dynamics of Upper Freeport coal powder and lumps AN - 50100689; 2010-012085 AB - Exposure to 7 MPa of helium at room temperature alters the texture of Upper Freeport coal in a lump form. The differences in texture and porosity between coal powder and lumps may affect the transport and interaction of fluids and coal. In this work, the information about the coal texture and micro- and meso-porosity was obtained via the BET, BJH, and Dubinin-Astakhov analyses. We further investigated the free-fluid-phase volume (free-volume) effects due to helium interaction with the powder and the lumps. During the manometric experiment, helium penetration into the dry coal matrix resulted in slow relaxation of pressure. After exposure of coal to helium, there have been no significant changes of the macroscopic dimensions observed and the relaxation process can be attributed to microscopic "free-volume" effects. Evolution of the sorption-desorption rates indicates that exposure to helium may change the texture and apparent (helium) density of dry coal. JF - International Journal of Coal Geology AU - Romanov, Vyacheslav AU - Soong, Y A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 10 EP - 15 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - United States KW - sorption KW - experimental studies KW - Pennsylvanian KW - Paleozoic KW - Carboniferous KW - porosity KW - gases KW - laboratory studies KW - physical properties KW - sedimentary rocks KW - Freeport Formation KW - noble gases KW - coal KW - volume KW - helium KW - thermodynamic properties KW - Pennsylvania KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50100689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Helium-volume+dynamics+of+Upper+Freeport+coal+powder+and+lumps&rft.au=Romanov%2C+Vyacheslav%3BSoong%2C+Y&rft.aulast=Romanov&rft.aufirst=Vyacheslav&rft.date=2009-01-01&rft.volume=77&rft.issue=1-2&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2008.05.015 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Carboniferous; coal; experimental studies; Freeport Formation; gases; helium; laboratory studies; noble gases; Paleozoic; Pennsylvania; Pennsylvanian; physical properties; porosity; sedimentary rocks; sorption; thermodynamic properties; United States; volume DO - http://dx.doi.org/10.1016/j.coal.2008.05.015 ER - TY - JOUR T1 - CO (sub 2) sequestration in coals and enhanced coalbed methane recovery AN - 50100667; 2010-012083 JF - International Journal of Coal Geology A2 - Karacan, C. Ozgen A2 - Larsen, John W. A2 - Esterle, J. S. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 1 EP - 242 PB - Elsevier, Amsterdam VL - 77 IS - 1-2 SN - 0166-5162, 0166-5162 KW - methane KW - carbon sequestration KW - natural gas KW - aliphatic hydrocarbons KW - petroleum KW - enhanced recovery KW - alkanes KW - carbon dioxide KW - organic compounds KW - sedimentary rocks KW - coal KW - hydrocarbons KW - coalbed methane KW - 29A:Economic geology, geology of energy sources KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50100667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2009-01-01&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=CO+%28sub+2%29+sequestration+in+coals+and+enhanced+coalbed+methane+recovery&rft.title=CO+%28sub+2%29+sequestration+in+coals+and+enhanced+coalbed+methane+recovery&rft.issn=01665162&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - SuppNotes - Individual papers are cited separately N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; carbon dioxide; carbon sequestration; coal; coalbed methane; enhanced recovery; hydrocarbons; methane; natural gas; organic compounds; petroleum; sedimentary rocks ER - TY - JOUR T1 - P14-04. HIV-SELECTEST EIA and rapid test: a novel assay for differential diagnosis of HIV infections in the face of vaccine-generated antibodies AN - 21461231; 11864573 JF - Retrovirology AU - Khurana, S AU - Norris, P J AU - Busch, M P AU - Mlisana, K AU - Salim, A K AU - Hunter, E AU - Golding, H AD - CBER, FDA, Bethesda, MD, USA Y1 - 2009 PY - 2009 DA - 2009 SP - P192 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 6 IS - Suppl 3 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Antibodies KW - Differential diagnosis KW - Human immunodeficiency virus KW - Infection KW - V 22360:AIDS and HIV KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21461231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Retrovirology&rft.atitle=P14-04.+HIV-SELECTEST+EIA+and+rapid+test%3A+a+novel+assay+for+differential+diagnosis+of+HIV+infections+in+the+face+of+vaccine-generated+antibodies&rft.au=Khurana%2C+S%3BNorris%2C+P+J%3BBusch%2C+M+P%3BMlisana%2C+K%3BSalim%2C+A+K%3BHunter%2C+E%3BGolding%2C+H&rft.aulast=Khurana&rft.aufirst=S&rft.date=2009-01-01&rft.volume=6&rft.issue=Suppl+3&rft.spage=P192&rft.isbn=&rft.btitle=&rft.title=Retrovirology&rft.issn=1742-4690&rft_id=info:doi/10.1186%2F1742-4690-6-S3-P192 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Antibodies; Differential diagnosis; Infection; Human immunodeficiency virus DO - http://dx.doi.org/10.1186/1742-4690-6-S3-P192 ER - TY - JOUR T1 - Genotypic and Phenotypic Assessment of Hyaluronidase among Type Strains of a Select Group of Staphylococcal Species AN - 21311153; 11932599 AB - Hyaluronidases degrade hyaluronic acid, a major polysaccharide of the extracellular matrix of tissues, and are considered important for virulence in a number of Gram-positive and -negative bacteria. The purpose of the present study was to determine the prevalence of hyaluronidase among clinical strains of Staphylococcus aureus and among other Staphylococcus species. Spent media and chromosomal DNA were assessed for hyaluronidase activity and the absence or presence of a hyaluronidase gene (hysA) by Southern analysis, respectively. All S. aureus strains examined exhibited at least one hybridizing band (half of the strains exhibited two or more hybridizing bands) when probed for hysA and all but three of these strains produced hyaluronidase. In contrast, none of the type strains of 19 other species exhibited either hyaluronidase activity or hybridizing bands when probed for hysA. These data support the hypothesis that among members of the Staphylococcus genus only strains of S. aureus possess the enzyme hyaluronidase. This would suggest that hyaluronidase represents yet another potential virulence factor employed by S. aureus to cause disease and may represent a diagnostically important characteristic for distinguishing S. aureus from other members of this genus. JF - International Journal of Microbiology AU - Hart, Mark E AU - Hart, Morgan J AU - Roop, Anna J AD - Division of Microbiology National Center for Toxicological Research U.S. Food and Drug Administration Jefferson, AR 72079 Y1 - 2009 PY - 2009 DA - 2009 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 USA VL - 2009 SN - 1687-918X, 1687-918X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Hyaluronic acid KW - Data processing KW - virulence factors KW - Extracellular matrix KW - DNA KW - Enzymes KW - Staphylococcus aureus KW - Polysaccharides KW - Hyaluronoglucuronidase KW - J 02310:Genetics & Taxonomy KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21311153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Microbiology&rft.atitle=Genotypic+and+Phenotypic+Assessment+of+Hyaluronidase+among+Type+Strains+of+a+Select+Group+of+Staphylococcal+Species&rft.au=Hart%2C+Mark+E%3BHart%2C+Morgan+J%3BRoop%2C+Anna+J&rft.aulast=Hart&rft.aufirst=Mark&rft.date=2009-01-01&rft.volume=2009&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Microbiology&rft.issn=1687918X&rft_id=info:doi/10.1155%2F2009%2F614371 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Hyaluronic acid; Data processing; virulence factors; Extracellular matrix; DNA; Enzymes; Polysaccharides; Hyaluronoglucuronidase; Staphylococcus aureus DO - http://dx.doi.org/10.1155/2009/614371 ER - TY - JOUR T1 - Prospective Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Assay for the Detection of Latent Tuberculosis Infection among Healthcare Workers in a Low-Incidence Setting AN - 21209248; 11189207 AB - We compared the results of the tuberculin skin test with the results of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay among 182 low-risk healthcare workers. Overall agreement and specificity were high, but the tests did not agree on positive results. Only 2 of 5 positive QFT-GIT assay results could be confirmed with repeat analyses. Indeterminate results were associated with potential immunosuppression. JF - Infection Control and Hospital Epidemiology AU - Cummings, Kristin J AU - Smith, Tamara S AU - Shogren, Elizabeth S AU - Khakoo, Rashida AU - Nanda, Sharmilarani AU - Bunner, Lana AU - Smithmyer, Ann AU - Soccorsi, Darlene AU - Kashon, Michael L AU - Mazurek, Gerald H AU - Friedman, Lloyd N AU - Weissman, David N AD - Division of Respiratory Disease Studies and the Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, the Section of Allergy and Immunology, Department of Pediatrics, and the Section of Infectious Diseases, Department of Medicine, and the Department of Pediatrics, West Virginia University School of Medicine, the University Health Associates, West Virginia University, and the Employee Health Department, West Virginia University Hospitals, Morgantown, West Virginia, cvx5@cdc.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 1123 EP - 1126 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 30 IS - 11 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Health & Safety Science Abstracts KW - Mycobacterium KW - Infection KW - Medical personnel KW - infection KW - Gold KW - Risk groups KW - Tuberculosis KW - Occupational exposure KW - Assays KW - Skin tests KW - tuberculosis KW - Tuberculin KW - Hospitals KW - Immunosuppression KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21209248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Prospective+Comparison+of+Tuberculin+Skin+Test+and+QuantiFERON-TB+Gold+In-Tube+Assay+for+the+Detection+of+Latent+Tuberculosis+Infection+among+Healthcare+Workers+in+a+Low-Incidence+Setting&rft.au=Cummings%2C+Kristin+J%3BSmith%2C+Tamara+S%3BShogren%2C+Elizabeth+S%3BKhakoo%2C+Rashida%3BNanda%2C+Sharmilarani%3BBunner%2C+Lana%3BSmithmyer%2C+Ann%3BSoccorsi%2C+Darlene%3BKashon%2C+Michael+L%3BMazurek%2C+Gerald+H%3BFriedman%2C+Lloyd+N%3BWeissman%2C+David+N&rft.aulast=Cummings&rft.aufirst=Kristin&rft.date=2009-01-01&rft.volume=30&rft.issue=11&rft.spage=1123&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F644754 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk groups; Gold; Tuberculosis; Tuberculin; Infection; Medical personnel; Immunosuppression; Hospitals; Skin tests; tuberculosis; infection; Assays; Occupational exposure; Mycobacterium DO - http://dx.doi.org/10.1086/644754 ER - TY - JOUR T1 - Monitoring of Pesticide Residues in Green Tea produced in Korea AN - 21147651; 11292219 AB - Herein, we present the results of our investigation of 61 pesticide residues in 100 samples of green teas obtained from Korean markets. Bifenthrin, chlorpyrifos, dicofol, EPN, chlorfenapyr, tebuconazole, cyhalothrin, difenoconazole, and tebufenpyrad were detected in 22 of the 100 green tea samples. The quantity of pesticide residues for bifenthrin was 0.12 ppm (maximum residue limits (MRLs): 0.3 ppm) in one sample, chlorpyrifos was 0.24-0.78 ppm (MRLs: 2.0 ppm) in three samples, dicofol was 1.64-4.19 ppm (MRLs: 50.0 ppm) in two samples, EPN was 0.13 ppm (MRLs: 0.05 ppm) in one sample, chlorfenapyr was 0.01-1.23 ppm (MRLs: 3.0 ppm) in 16 samples, tebuconazole was 0.71 ppm (MRLs: 5.0 ppm) in one sample, cyhalothrin was 0.05-0.3 ppm (MRLs: 2.0 ppm) in five samples, difenoconazole was 0.23 ppm (MRLs: 2.0 ppm) in one sample, and tebufenpyrad was 0.06-0.07 ppm (MRLs: 2.0 ppm) in two samples. More than two pesticide residues were detected in seven samples. All detected pesticide residues (with the exception of EPN) were within the MRLs. JF - Korean Journal of Food Science and Technology AU - Hee-Yun, K AU - Jong-Sup, J AU - Yong-Hoon, K AU - Hee-Ju, C AU - So-Young, C AU - Hwa-Jeong, L AU - Jae-In, K AU - Young-Seon, K AU - Gye-Sun, C AU - Jae-Chun, C AD - Seoul Regional Korea Food and Drug Administration, Seoul 158-050, Korea, chjatu@kfda.go.kr Y1 - 2009 PY - 2009 DA - 2009 SP - 483 EP - 489 VL - 41 IS - 5 SN - 0367-6293, 0367-6293 KW - Health & Safety Science Abstracts KW - Chlorpyrifos KW - Pesticide residues KW - Pesticides KW - Korea, Rep. KW - tea KW - H 5000:Pesticides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21147651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Korean+Journal+of+Food+Science+and+Technology&rft.atitle=Monitoring+of+Pesticide+Residues+in+Green+Tea+produced+in+Korea&rft.au=Hee-Yun%2C+K%3BJong-Sup%2C+J%3BYong-Hoon%2C+K%3BHee-Ju%2C+C%3BSo-Young%2C+C%3BHwa-Jeong%2C+L%3BJae-In%2C+K%3BYoung-Seon%2C+K%3BGye-Sun%2C+C%3BJae-Chun%2C+C&rft.aulast=Hee-Yun&rft.aufirst=K&rft.date=2009-01-01&rft.volume=41&rft.issue=5&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Korean+Journal+of+Food+Science+and+Technology&rft.issn=03676293&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Chlorpyrifos; Pesticide residues; Pesticides; tea; Korea, Rep. ER - TY - JOUR T1 - A Novel Combination of Factors, Termed SPIE, which Promotes Dopaminergic Neuron Differentiation from Human Embryonic Stem Cells AN - 21066878; 10989799 AB - Background Stromal-Derived Inducing Activity (SDIA) is one of the most efficient methods of generating dopaminergic (DA) neurons from embryonic stem cells (ESC). DA neuron induction can be achieved by co-culturing ESC with the mouse stromal cell lines PA6 or MS5. The molecular nature of this effect, which has been termed aSDIAa is so far unknown. Recently, we found that factors secreted by PA6 cells provided lineage-specific instructions to induce DA differentiation of human ESC (hESC). Methodology/Principal Findings In the present study, we compared PA6 cells to various cell lines lacking the SDIA effect, and employed genome expression analysis to identify differentially-expressed signaling molecules. Among the factors highly expressed by PA6 cells, and known to be associated with CNS development, were stromal cell-derived factor 1 (SDF-1/CXCL12), pleiotrophin (PTN), insulin-like growth factor 2 (IGF2), and ephrin B1 (EFNB1). When these four factors, the combination of which was termed SPIE, were applied to hESC, they induced differentiation to TH-positive neurons in vitro. RT-PCR and western blot analysis confirmed the expression of midbrain specific markers, including engrailed 1, Nurr1, Pitx3, and dopamine transporter (DAT) in cultures influenced by these four molecules. Electrophysiological recordings showed that treatment of hESC with SPIE induced differentiation of neurons that were capable of generating action potentials and forming functional synaptic connections. Conclusions/Significance The combination of SDF-1, PTN, IGF2, and EFNB1 mimics the DA phenotype-inducing property of SDIA and was sufficient to promote differentiation of hESC to functional midbrain DA neurons. These findings provide a method for differentiating hESC to form DA neurons, without a requirement for the use of animal-derived cell lines or products. JF - PLoS ONE AU - Vazin, Tandis AU - Becker, Kevin G AU - Chen, Jia AU - Spivak, Charles E AU - Lupica, Carl R AU - Zhang, Yongqing AU - Worden, Lila AU - Freed, William J AU - Hashimoto, Kenji AD - Cellular Neurobiology Research Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Baltimore, Maryland, United States of America Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 4 IS - 8 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - SDF-1 protein KW - Central nervous system KW - stromal cells KW - Cell culture KW - ephrins KW - Differentiation KW - Mesencephalon KW - Action potential KW - Dopamine transporter KW - Stem cells KW - Neurogenesis KW - Embryo cells KW - Polymerase chain reaction KW - Insulin-like growth factor II KW - Western blotting KW - Synapses KW - Nuclear receptors KW - pleiotrophin KW - Nurr1 protein KW - Electrophysiological recording KW - Neurons KW - Insulin-like growth factors KW - CXCL12 protein KW - Signal transduction KW - G 07730:Development & Cell Cycle KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21066878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=A+Novel+Combination+of+Factors%2C+Termed+SPIE%2C+which+Promotes+Dopaminergic+Neuron+Differentiation+from+Human+Embryonic+Stem+Cells&rft.au=Vazin%2C+Tandis%3BBecker%2C+Kevin+G%3BChen%2C+Jia%3BSpivak%2C+Charles+E%3BLupica%2C+Carl+R%3BZhang%2C+Yongqing%3BWorden%2C+Lila%3BFreed%2C+William+J%3BHashimoto%2C+Kenji&rft.aulast=Vazin&rft.aufirst=Tandis&rft.date=2009-01-01&rft.volume=4&rft.issue=8&rft.spage=e6606&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0006606 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Central nervous system; SDF-1 protein; stromal cells; ephrins; Cell culture; Mesencephalon; Differentiation; Neurogenesis; Stem cells; Dopamine transporter; Action potential; Embryo cells; Polymerase chain reaction; Insulin-like growth factor II; Western blotting; Synapses; Nuclear receptors; pleiotrophin; Electrophysiological recording; Nurr1 protein; Neurons; Insulin-like growth factors; CXCL12 protein; Signal transduction DO - http://dx.doi.org/10.1371/journal.pone.0006606 ER - TY - JOUR T1 - Contextualization of Physical and Sexual Assault in Male Prisons: Incidents and Their Aftermath AN - 21048206; 9401040 AB - Physical and sexual assault are part of the prison experience. Approximately 21% of male inmates are physically assaulted during a 6-month period. Sexual assault is estimated at between 2% and 5%. Although prevalence evidence is growing, less is known about circumstances surrounding and resulting from these incidents. This article presents an analysis of approximately 2,200 physical and 200 sexual victimizations reported by a random sample of 6,964 male inmates. Physical injury occurred in 40% of physical assaults and 70% of sexual assaults between inmates and in 50% of assaults perpetrated by staff. Emotional reactions to assaults were experienced by virtually all victims. Context information is vital in the development and implementation of prevention and therapeutic interventions. JF - Journal of Correctional Health Care AU - Wolff, Nancy AU - Shi, Jing AD - Center for Mental Health Services and Criminal Justice Research, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, nwolff@ifh.rutgers.edu Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 58 EP - 77 PB - Sage Publications Ltd., 6 Bonhill St. VL - 15 IS - 1 SN - 1078-3458, 1078-3458 KW - Risk Abstracts KW - sexual assault KW - physical assault KW - inmate safety KW - prevention KW - correctional health KW - prisons KW - Health care KW - Injuries KW - intervention KW - males KW - Sexual assault KW - victimization KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21048206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Correctional+Health+Care&rft.atitle=Contextualization+of+Physical+and+Sexual+Assault+in+Male+Prisons%3A+Incidents+and+Their+Aftermath&rft.au=Wolff%2C+Nancy%3BShi%2C+Jing&rft.aulast=Wolff&rft.aufirst=Nancy&rft.date=2009-01-01&rft.volume=15&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Journal+of+Correctional+Health+Care&rft.issn=10783458&rft_id=info:doi/10.1177%2F1078345808326622 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - prisons; Injuries; Health care; intervention; prevention; males; Sexual assault; victimization DO - http://dx.doi.org/10.1177/1078345808326622 ER - TY - JOUR T1 - Embracing a Clean-Energy Future AN - 20842913; 10981265 AB - The former governor of Kansas describes how her state is greening. The Blue Green Alliance has estimated that in a renewable-energy economy, Kansas stands to gain more than 11,000 jobs and almost $2 billion in new economic investments. JF - New Solutions AU - Sebeilus, K AD - U.S. Department of Health and Human Services, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 147 EP - 148 VL - 19 IS - 2 SN - 1048-2911, 1048-2911 KW - Sustainability Science Abstracts KW - Economics KW - USA, Kansas KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20842913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+Solutions&rft.atitle=Embracing+a+Clean-Energy+Future&rft.au=Sebeilus%2C+K&rft.aulast=Sebeilus&rft.aufirst=K&rft.date=2009-01-01&rft.volume=19&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=New+Solutions&rft.issn=10482911&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Kansas; Economics ER - TY - JOUR T1 - Human embryonic stem cells which express hrGFP in the undifferentiated state and during dopaminergic differentiation AN - 20834079; 11011945 AB - Purpose: human embryonic stem cells (hESCs) which express a reporter gene consistently during all phases of differentiation would be valuable for basic research on cell transplantation. In this study, we describe karyotypically-abnormal variant hESCs, BGO1V2-EFG, which express hrGFP driven by the EF1 promoter.Methods: BGO1V2-EFG cells were analyzed by using immunocytochemistry, single cell-based confocal image, and in vitro differentiation, including dopaminergic differentiation.Results: Undifferentiated BGO1V2-EFG cells expressed pluripotent ESC markers and retained the ability to differentiate into cell types of all three germ layers. BGO1V2-EFG cells maintained stable and robust hrGFP expression in vitro in the undifferentiated state and during differentiation. The EF1 promoter retained activity during dopaminergic differentiation, as 76% of tyrosine hydroxlase (TH)-positive cells co-expressed hrGFP by confocal analysis. Treated with sodium butyrate (0.02 mM to 2.0 mM), an inhibitor of histone deacetylase (HDAC), during differentiation did not affect hrGFP expression, although TH expression was reduced by higher concentrations of sodium butyrate.Conclusion: BGO1V2-EFG cells maintain stable and robust hrGFP expression in the undifferentiated state and during neural differentiation. Especially, the EF1 promoter was effective in driving hrGFP expression during dopaminergic differentiation. BGO1V2-EFG cells may be useful for transplantation studies in Parkinson disease animal models. JF - Restorative Neurology and Neuroscience AU - Chen, Jia AU - Tsai, Shang-Yi AU - Vazin, Tandis AU - Coggiano, Mark AU - Freed, William J AD - Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 359 EP - 370 PB - IOS Press, Nieuwe Hemweg 6B Amsterdam 1013 BG The Netherlands VL - 27 IS - 4 SN - 0922-6028, 0922-6028 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; CSA Neurosciences Abstracts KW - Immunocytochemistry KW - Histone deacetylase KW - Transplantation KW - Parkinson's disease KW - Animal models KW - Tyrosine KW - Neurodegenerative diseases KW - Promoters KW - Differentiation KW - Nervous system KW - Stem cells KW - Movement disorders KW - Dopamine KW - Embryo cells KW - Reporter gene KW - Sodium butyrate KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20834079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Restorative+Neurology+and+Neuroscience&rft.atitle=Human+embryonic+stem+cells+which+express+hrGFP+in+the+undifferentiated+state+and+during+dopaminergic+differentiation&rft.au=Chen%2C+Jia%3BTsai%2C+Shang-Yi%3BVazin%2C+Tandis%3BCoggiano%2C+Mark%3BFreed%2C+William+J&rft.aulast=Chen&rft.aufirst=Jia&rft.date=2009-01-01&rft.volume=27&rft.issue=4&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Restorative+Neurology+and+Neuroscience&rft.issn=09226028&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Immunocytochemistry; Transplantation; Parkinson's disease; Animal models; Tyrosine; Differentiation; Promoters; Neurodegenerative diseases; Stem cells; Nervous system; Dopamine; Movement disorders; Embryo cells; Reporter gene; Sodium butyrate ER - TY - JOUR T1 - Human Organ/Tissue Growth Algorithms that Include Obese Individuals and Black/White Population Organ Weight Similarities from Autopsy Data AN - 20741814; 9315209 AB - Physiologically based pharmacokinetic (PBPK) models need the correct organ/tissue weights to match various total body weights in order to be applied to children and the obese individual. Baseline data from Reference Man for the growth of human organs (adrenals, brain, heart, kidneys, liver, lungs, pancreas, spleen, thymus, and thyroid) were augmented with autopsy data to extend the describing polynomials to include the morbidly obese individual (up to 250 kg). Additional literature data similarly extends the growth curves for blood volume, muscle, skin, and adipose tissue. Collectively these polynomials were used to calculate blood/organ/tissue weights for males and females from birth to 250 kg, which can be directly used to help parameterize PBPK models. In contrast to other black/white anthropomorphic measurements, the data demonstrated no observable or statistical difference in weights for any organ/tissue between individuals identified as black or white in the autopsy reports. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Young, J F AU - Luecke, R H AU - Pearce, BA AU - Lee, T AU - Ahn, H AU - Baek, S AU - Moon, H AU - Dye, D W AU - Davis, T M AU - Taylor, S J AD - Division of Personalized Nutrition & Medicine, National Center for Toxicological Research, Jefferson, AR 72079, USA, johnfyoung@aristotle.net Y1 - 2009 PY - 2009 DA - 2009 SP - 527 EP - 540 VL - 72 IS - 7-8 SN - 1528-7394, 1528-7394 KW - Environment Abstracts; Toxicology Abstracts KW - Adipose tissue KW - Data processing KW - Organs KW - X 24310:Pharmaceuticals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20741814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Human+Organ%2FTissue+Growth+Algorithms+that+Include+Obese+Individuals+and+Black%2FWhite+Population+Organ+Weight+Similarities+from+Autopsy+Data&rft.au=Young%2C+J+F%3BLuecke%2C+R+H%3BPearce%2C+BA%3BLee%2C+T%3BAhn%2C+H%3BBaek%2C+S%3BMoon%2C+H%3BDye%2C+D+W%3BDavis%2C+T+M%3BTaylor%2C+S+J&rft.aulast=Young&rft.aufirst=J&rft.date=2009-01-01&rft.volume=72&rft.issue=7-8&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390802647203 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Data processing; Organs DO - http://dx.doi.org/10.1080/15287390802647203 ER - TY - JOUR T1 - Common Gene Variants in the Tumor Necrosis Factor (TNF) and TNF Receptor Superfamilies and NF-kB Transcription Factors and Non-Hodgkin Lymphoma Risk AN - 20741180; 9305299 AB - Background A promoter polymorphism in the pro-inflammatory cytokine tumor necrosis factor (TNF) (TNF G-308A) is associated with increased non-Hodgkin lymphoma (NHL) risk. The protein product, TNF-I-, activates the nuclear factor kappa beta (NF-IoB) transcription factor, and is critical for inflammatory and apoptotic responses in cancer progression. We hypothesized that the TNF and NF-IoB pathways are important for NHL and that gene variations across the pathways may alter NHL risk. Methodology/Principal Findings We genotyped 500 tag single nucleotide polymorphisms (SNPs) from 48 candidate gene regions (defined as 20 kb 5a2, 10 kb 3a2) in the TNF and TNF receptor superfamilies and the NF-IoB and related transcription factors, in 1946 NHL cases and 1808 controls pooled from three independent population-based case-control studies. We obtaineded a gene region-level summary of association by computing the minimum p-value (aminP testa). We used logistic regression to compute odds ratios and 95% confidence intervals for NHL and four major NHL subtypes in relation to SNP genotypes and haplotypes. For NHL, the tail strength statistic supported an overall relationship between the TNF/NF-IoB pathway and NHL (p = 0.02). We confirmed the association between TNF/LTA on chromosome 6p21.3 with NHL and found the LTA rs2844484 SNP most significantly and specifically associated with the major subtype, diffuse large B-cell lymphoma (DLBCL) (p-trend = 0.001). We also implicated for the first time, variants in NFKBIL1 on chromosome 6p21.3, associated with NHL. Other gene regions identified as statistically significantly associated with NHL included FAS, IRF4, TNFSF13B, TANK, TNFSF7 and TNFRSF13C. Accordingly, the single most significant SNPs associated with NHL were FAS rs4934436 (p-trend = 0.0024), IRF4 rs12211228 (p-trend = 0.0026), TNFSF13B rs2582869 (p-trend = 0.0055), TANK rs1921310 (p-trend = 0.0025), TNFSF7 rs16994592 (p-trend = 0.0024), and TNFRSF13C rs6002551 (p-trend = 0.0074). All associations were consistent in each study with no apparent specificity for NHL subtype. Conclusions/Significance Our results provide consistent evidence that variation in the TNF superfamily of genes and specifically within chromosome 6p21.3 impacts lymphomagenesis. Further characterization of these susceptibility loci and identification of functional variants are warranted. JF - PLoS ONE AU - Wang, Sophia S AU - Purdue, Mark P AU - Cerhan, James R AU - Zheng, Tongzhang AU - Menashe, Idan AU - Armstrong, Bruce K AU - Lan, Qing AU - Hartge, Patricia AU - Kricker, Anne AU - Zhang, Yawei AU - Morton, Lindsay M AU - Vajdic, Claire M AU - Holford, Theodore R AU - Severson, Richard K AU - Grulich, Andrew AU - Leaderer, Brian P AU - Davis, Scott AU - Cozen, Wendy AU - Yeager, Meredith AU - Chanock, Stephen J AU - Chatterjee, Nilanjan AU - Rothman, Nathaniel AU - Bauer, Joseph Alan AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, United States of America Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House VL - 4 IS - 4 SN - 1932-6203, 1932-6203 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - double prime B-cell lymphoma KW - Apoptosis KW - Tails KW - Gene polymorphism KW - Interferon regulatory factor 4 KW - Tumor necrosis factor KW - Tumor necrosis factor receptors KW - chromosome 6 KW - Cancer KW - Inflammation KW - NF- Kappa B protein KW - Haplotypes KW - Fas antigen KW - Single-nucleotide polymorphism KW - Transcription factors KW - Cytokines KW - CD95 antigen KW - A 01310:Products of Microorganisms KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20741180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Common+Gene+Variants+in+the+Tumor+Necrosis+Factor+%28TNF%29+and+TNF+Receptor+Superfamilies+and+NF-kB+Transcription+Factors+and+Non-Hodgkin+Lymphoma+Risk&rft.au=Wang%2C+Sophia+S%3BPurdue%2C+Mark+P%3BCerhan%2C+James+R%3BZheng%2C+Tongzhang%3BMenashe%2C+Idan%3BArmstrong%2C+Bruce+K%3BLan%2C+Qing%3BHartge%2C+Patricia%3BKricker%2C+Anne%3BZhang%2C+Yawei%3BMorton%2C+Lindsay+M%3BVajdic%2C+Claire+M%3BHolford%2C+Theodore+R%3BSeverson%2C+Richard+K%3BGrulich%2C+Andrew%3BLeaderer%2C+Brian+P%3BDavis%2C+Scott%3BCozen%2C+Wendy%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BChatterjee%2C+Nilanjan%3BRothman%2C+Nathaniel%3BBauer%2C+Joseph+Alan&rft.aulast=Wang&rft.aufirst=Sophia&rft.date=2009-01-01&rft.volume=4&rft.issue=4&rft.spage=e5360&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0005360 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Apoptosis; double prime B-cell lymphoma; Tails; Tumor necrosis factor; Interferon regulatory factor 4; Gene polymorphism; Cancer; chromosome 6; Tumor necrosis factor receptors; NF- Kappa B protein; Inflammation; Haplotypes; Single-nucleotide polymorphism; Fas antigen; Transcription factors; CD95 antigen; Cytokines DO - http://dx.doi.org/10.1371/journal.pone.0005360 ER - TY - JOUR T1 - Evaluation of substrates for 90° peel adhesion - A collaborative study. II. Transdermal drug delivery systems AN - 20587598; 9304250 AB - In a previous study on peel adhesion for medical tapes, it was shown that a stainless steel (SS) substrate better discriminated among medical tapes than a high-density polyethylene (HDPE) substrate. The objective of this study was to determine if a SS substrate would also better distinguish among transdermal drug delivery systems (TDDSs). Five TDDSs (Vivelle Dot(r), Climara(r), Catapres-TTS(r), Duragesic(r), and Mylan Fentanyl) were evaluated on three different substrates (SS, HDPE, and human cadaver skin). All measurements were made using a dwell time of 3 min, a peel angle of 90°, and a peel speed of 300 mm/min. Differences among TDDSs were greater for SS than for HDPE, using the F statistic for testing for differences among TDDSs means as a measure of heterogeneity, thereby indicating greater discrimination by SS. JF - Journal of Biomedical Materials Research Part B AU - Wokovich, Anna M AU - Brown, Stanley A AU - Shen, Meiyu AU - Doub, William H AU - Cai, Bing AU - Sadrieh, Nakissa AU - Chen, Mei Ling AU - Machado, Stella AU - Buhse, Lucinda F AD - Center for Drug Evaluation and Research, Food and Drug Administration, St. Louis, Missouri, anna.wokovich@fda.hhs.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 61 EP - 65 PB - John Wiley & Sons, Inc. VL - 88B IS - 1 SN - 1552-4973, 1552-4973 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Skin KW - Polyethylene KW - Cadavers KW - fentanyl KW - stainless steel KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20587598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research+Part+B&rft.atitle=Evaluation+of+substrates+for+90%C2%B0+peel+adhesion+-+A+collaborative+study.+II.+Transdermal+drug+delivery+systems&rft.au=Wokovich%2C+Anna+M%3BBrown%2C+Stanley+A%3BShen%2C+Meiyu%3BDoub%2C+William+H%3BCai%2C+Bing%3BSadrieh%2C+Nakissa%3BChen%2C+Mei+Ling%3BMachado%2C+Stella%3BBuhse%2C+Lucinda+F&rft.aulast=Wokovich&rft.aufirst=Anna&rft.date=2009-01-01&rft.volume=88B&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research+Part+B&rft.issn=15524973&rft_id=info:doi/10.1002%2Fjbm.b.31149 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Drug delivery; Skin; Polyethylene; Cadavers; fentanyl; stainless steel DO - http://dx.doi.org/10.1002/jbm.b.31149 ER - TY - JOUR T1 - A Microarray Based Approach for the Identification of Common Foodborne Viruses AN - 20489093; 9188990 AB - An oligonucleotide array (microarray) incorporating 13,000 elements representing selected strains of hepatitis A virus (HAV), human coxsackieviruses A and B (CVA and CVB), genogroups I and II of Norovirus (NV), and human rotavirus (RV) gene segments 3,4,10, and 11 was designed based on the principle of tiling. Each oligonucleotide was 29 bases long, starting at every 5th base of every sequence, resulting in an overlap of 24 bases in two consecutive oligonucleotides. The applicability of the array for virus identification was examined using PCR amplified products from multiple HAV and CV strains. PCR products labeled with biotin were hybridized to the array, and the biotin was detected using a brief reaction with Cy3-labeled streptavidin, the array subjected to laser scanning, and the hybridization data plotted as fluorescence intensity against each oligonucleotide in the array. The combined signal intensities of all probes representing a particular strain of virus were calculated and plotted against all virus strains identified on a linear representation of the array. The profile of the total signal intensity identified the strain that is most likely represented in the amplified cDNA target. The results obtained with HAV and CV indicated that the hybridization profile thus generated can be used to identify closely related viral strains. This represents a significant improvement over current methods for virus identification using PCR amplification and amplicon sequencing. JF - Open Virology Journal AU - Ayodeji, Mobolanle AU - Kulka, Michael AU - Jackson, Scott A AU - Patel, Isha AU - Mammel, Mark AU - Cebula, Thomas A AU - Goswami, Biswendu B AD - Division of Molecular Biology, Office of Applied Research and Safety Assessment (OARSA), Food and Drug Administration, 8301 Muirkirk Road, HFS- 025, Laurel, MD, 20708, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 7 EP - 20 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [URL:http://www.bentham.org] VL - 3 KW - Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Data processing KW - Fluorescence KW - Human rotavirus KW - Food KW - Hepatitis A virus KW - Viruses KW - Probes KW - Norovirus KW - hepatitis A KW - Oligonucleotides KW - DNA microarrays KW - Polymerase chain reaction KW - Biotin KW - streptavidin KW - H 4000:Food and Drugs KW - W 30900:Methods KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20489093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open+Virology+Journal&rft.atitle=A+Microarray+Based+Approach+for+the+Identification+of+Common+Foodborne+Viruses&rft.au=Ayodeji%2C+Mobolanle%3BKulka%2C+Michael%3BJackson%2C+Scott+A%3BPatel%2C+Isha%3BMammel%2C+Mark%3BCebula%2C+Thomas+A%3BGoswami%2C+Biswendu+B&rft.aulast=Ayodeji&rft.aufirst=Mobolanle&rft.date=2009-01-01&rft.volume=3&rft.issue=&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Open+Virology+Journal&rft.issn=1874-3579&rft_id=info:doi/10.2174%2F1874357900903010007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Fluorescence; Data processing; Food; Probes; Polymerase chain reaction; DNA microarrays; Biotin; Oligonucleotides; streptavidin; Viruses; hepatitis A; Human rotavirus; Hepatitis A virus; Norovirus DO - http://dx.doi.org/10.2174/1874357900903010007 ER - TY - JOUR T1 - Preparation and characterization of an immunogenic meningococcal group A conjugate vaccine for use in Africa AN - 20395572; 9068065 AB - Periodic epidemics of group A meningococcal (Mn A) meningitis continue to occur in sub-Saharan Africa. For its prevention, a Mn A polysaccharide (PS)-tetanus toxoid (TT) conjugate vaccine was developed using reductive amination of polysaccharide aldehydes and toxoid hydrazides. In mouse immunization studies, a schedule of three bi-weekly s.c. immunizations of 0.1 or 1 mg of the conjugate (PS content) without an adjuvant induced serum antibody levels of >10,000 units/mL measured by enzyme-linked immunosorbent assay (ELISA) as compared to 100 units/mL in PS control mice. The elicited antibodies were active in bactericidal assays using either baby rabbit or human complement (titers >1500 compared to 200 for the PS control group). The synthesis process is reproducible and scalable, and has been successfully used for manufacturing a Mn A PS-TT conjugate vaccine based on a paradigm of shared manufacturing with transfer of new technology [Jodar L, LaForce FM, Ceccarini C, Aguado T, Granoff DM. Meningococcal conjugate vaccine for Africa: a model for development of new vaccine for the poorest countries. Lancet 2003, 361:1092-4]. A phase 1 clinical trial of the manufactured Men A-TT conjugate vaccine has been successfully carried out in adults in India, and a phase 2 clinical trial in young children is currently underway in Africa. JF - Vaccine AU - Lee, Che-Hung AU - Kuo, Wen-Chun AU - Beri, Suresh AU - Kapre, Subash AU - Joshi, Jayant S AU - Bouveret, Nancy AU - Laforce, F Marc AU - Frasch, Carl E AD - Center for Biologics Evaluation and Research, Bethesda, MD, USA, robert.lee@fda.hhs.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 726 EP - 732 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 27 IS - 5 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Vaccine KW - Conjugate KW - Polysaccharide KW - Enzyme-linked immunosorbent assay KW - Epidemics KW - Neisseria meningitidis KW - Adjuvants KW - Toxoids KW - Polysaccharides KW - Children KW - Clinical trials KW - Immunization KW - Meningitis KW - Models KW - Antibodies KW - Immunogenicity KW - Vaccines KW - Aldehydes KW - Manganese KW - F 06900:Methods KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20395572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Preparation+and+characterization+of+an+immunogenic+meningococcal+group+A+conjugate+vaccine+for+use+in+Africa&rft.au=Lee%2C+Che-Hung%3BKuo%2C+Wen-Chun%3BBeri%2C+Suresh%3BKapre%2C+Subash%3BJoshi%2C+Jayant+S%3BBouveret%2C+Nancy%3BLaforce%2C+F+Marc%3BFrasch%2C+Carl+E&rft.aulast=Lee&rft.aufirst=Che-Hung&rft.date=2009-01-01&rft.volume=27&rft.issue=5&rft.spage=726&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.11.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Epidemics; Toxoids; Adjuvants; Children; Polysaccharides; Clinical trials; Immunization; Models; Meningitis; Antibodies; Immunogenicity; Vaccines; Aldehydes; Manganese; Neisseria meningitidis DO - http://dx.doi.org/10.1016/j.vaccine.2008.11.065 ER - TY - JOUR T1 - Cytotoxic Necrotizing Factor Type 1-Neutralizing Monoclonal Antibody NG8 Recognizes Three Amino Acids in a C-Terminal Region of the Toxin and Reduces Toxin Binding to HEp-2 Cells AN - 20383879; 9065248 AB - Cytotoxic necrotizing factor type 1 (CNF1) and CNF2 are toxins of pathogenic Escherichia coli that share 85% identity over 1,014 amino acids. Although both of these toxins modify GTPases, CNF1 is a more potent inducer of multinucleation in HEp-2 cells, binds more efficiently to HEp-2 cells, and, despite the conservation of amino acids (C866 and H881) required for enzymatic activity of the toxins, deamidates RhoA and Cdc42 better than CNF2. Here we exploited the differences between CNF1 and CNF2 to define the epitope on CNF1 to which the CNF1-specific neutralizing monoclonal antibody (MAb) (MAb NG8) binds and to determine the mechanism by which MAb NG8 neutralizes CNF1 activity on HEp-2 cells. For these purposes, we generated a panel of 21 site-directed mutants in which amino acids in CNF1 were exchanged for the amino acids in CNF2 between amino acids 546 and 869 and vice versa. This region of CNF1 not only is recognized by MAb NG8 but also is involved in binding of this toxin to HEp-2 cells. All the mutants retained the capacity to induce multinucleation of HEp-2 cells. However, the CNF1 double mutant with D591E and F593L mutations (CNF1 sub(D591E F593L)) and the CNF1 sub(H661Q) single mutant displayed drastically reduced reactivity with MAb NG8. A reverse chimeric triple mutant, CNF1 sub(E591D L593F Q661H), imparted MAb NG8 reactivity to CNF2. MAb NG8 neutralized CNF2 sub(E591D L593F Q661H) activity in a dose-dependent manner and reduced the binding of this chimeric toxin to HEp-2 cells. Taken together, these results pinpoint three amino acids in CNF1 that are key amino acids for recognition by neutralizing MAb NG8 and further help define a region in CNF1 that is critical for full toxin binding to HEp-2 cells. JF - Infection and Immunity AU - Grande, Kerian K AU - Meysick, Karen C AU - Rasmussen, Susan B AU - O'Brien, Alison D AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. FDA/CBER, Bethesda, Maryland 20892 Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 170 EP - 179 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Amino acids KW - Monoclonal antibodies KW - Cdc42 protein KW - Toxins KW - RhoA protein KW - Cytotoxic necrotizing factor KW - Escherichia coli KW - Conservation KW - Enzymatic activity KW - Mutation KW - Epitopes KW - Guanosinetriphosphatase KW - X 24490:Other KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20383879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Cytotoxic+Necrotizing+Factor+Type+1-Neutralizing+Monoclonal+Antibody+NG8+Recognizes+Three+Amino+Acids+in+a+C-Terminal+Region+of+the+Toxin+and+Reduces+Toxin+Binding+to+HEp-2+Cells&rft.au=Grande%2C+Kerian+K%3BMeysick%2C+Karen+C%3BRasmussen%2C+Susan+B%3BO%27Brien%2C+Alison+D&rft.aulast=Grande&rft.aufirst=Kerian&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Amino acids; Monoclonal antibodies; Cytotoxic necrotizing factor; Conservation; Cdc42 protein; Enzymatic activity; Mutation; Epitopes; Toxins; RhoA protein; Guanosinetriphosphatase; Escherichia coli ER - TY - JOUR T1 - Four Superoxide Dismutases Contribute to Bacillus anthracis Virulence and Provide Spores with Redundant Protection from Oxidative Stress AN - 20383053; 9065261 AB - The Bacillus anthracis genome encodes four superoxide dismutases (SODs), enzymes capable of detoxifying oxygen radicals. That two of these SODs, SOD15 and SODA1, are present in the outermost layers of the B. anthracis spore is indicated by previous proteomic analyses of the exosporium. Given the requirement that spores must survive interactions with reactive oxygen species generated by cells such as macrophages during infection, we hypothesized that SOD15 and SODA1 protect the spore from oxidative stress and contribute to the pathogenicity of B. anthracis. To test these theories, we constructed a double-knockout ( Delta sod15 Delta sodA1) mutant of B. anthracis Sterne strain 34F2 and assessed its lethality in an A/J mouse intranasal infection model. The 50% lethal dose of the Delta sod15 Delta sodA1 strain was similar to that of the wild type (34F2), but surprisingly, measurable whole-spore SOD activity was greater than that in 34F2. A quadruple-knockout strain ( Delta sod15 Delta sodA1 Delta sodC Delta sodA2) was then generated, and as anticipated, spore-associated SOD activity was diminished. Moreover, the quadruple-knockout strain, compared to the wild type, was attenuated more than 40-fold upon intranasal challenge of mice. Spore resistance to exogenously generated oxidative stress and to macrophage-mediated killing correlated with virulence in A/J mice. Allelic exchange that restored sod15 and sodA1 to their wild-type state restored wild-type characteristics. We conclude that SOD molecules within the spore afford B. anthracis protection against oxidative stress and enhance the pathogenicity of B. anthracis in the lung. We also surmise that the presence of four SOD alleles within the genome provides functional redundancy for this key enzyme. JF - Infection and Immunity AU - Cybulski, Robert J, Jr AU - Sanz, Patrick AU - Alem, Farhang AU - Stibitz, Scott AU - Bull, Robert L AU - O'Brien, Alison D AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799. FDA CBER, Division of Bacterial, Parasitic and Allergenic Products, NIH Campus Building 29, Room 201, HFM-440, Bethesda, Maryland 20892. Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, Maryland 20910 Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 274 EP - 285 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Macrophages KW - Genomes KW - Animal models KW - Enzymes KW - Bacillus anthracis KW - Infection KW - Virulence KW - Lethality KW - Pathogenicity KW - Reactive oxygen species KW - Oxidative stress KW - Superoxide dismutase KW - Lung KW - proteomics KW - Spores KW - Lethal dose KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20383053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Four+Superoxide+Dismutases+Contribute+to+Bacillus+anthracis+Virulence+and+Provide+Spores+with+Redundant+Protection+from+Oxidative+Stress&rft.au=Cybulski%2C+Robert+J%2C+Jr%3BSanz%2C+Patrick%3BAlem%2C+Farhang%3BStibitz%2C+Scott%3BBull%2C+Robert+L%3BO%27Brien%2C+Alison+D&rft.aulast=Cybulski&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Macrophages; Animal models; Enzymes; Infection; Virulence; Lethality; Reactive oxygen species; Pathogenicity; Lung; Superoxide dismutase; Oxidative stress; proteomics; Spores; Lethal dose; Bacillus anthracis ER - TY - JOUR T1 - Role of Anthrax Toxins in Dissemination, Disease Progression, and Induction of Protective Adaptive Immunity in the Mouse Aerosol Challenge Model AN - 20382514; 9065259 AB - Anthrax toxins significantly contribute to anthrax disease pathogenesis, and mechanisms by which the toxins affect host cellular responses have been identified with purified toxins. However, the contribution of anthrax toxin proteins to dissemination, disease progression, and subsequent immunity after aerosol infection with spores has not been clearly elucidated. To better understand the role of anthrax toxins in pathogenesis in vivo and to investigate the contribution of antibody to toxin proteins in protection, we completed a series of in vivo experiments using a murine aerosol challenge model and a collection of in-frame deletion mutants lacking toxin components. Our data show that after aerosol exposure to Bacillus anthracis spores, anthrax lethal toxin was required for outgrowth of bacilli in the draining lymph nodes and subsequent progression of infection beyond the lymph nodes to establish disseminated disease. After pulmonary exposure to anthrax spores, toxin expression was required for the development of protective immunity to a subsequent lethal challenge. However, immunoglobulin (immunoglobulin G) titers to toxin proteins, prior to secondary challenge, did not correlate with the protection observed upon secondary challenge with wild-type spores. A correlation was observed between survival after secondary challenge and rapid anamnestic responses directed against toxin proteins. Taken together, these studies indicate that anthrax toxins are required for dissemination of bacteria beyond the draining lymphoid tissue, leading to full virulence in the mouse aerosol challenge model, and that primary and anamnestic immune responses to toxin proteins provide protection against subsequent lethal challenge. These results provide support for the utility of the mouse aerosol challenge model for the study of inhalational anthrax. JF - Infection and Immunity AU - Loving, Crystal L AU - Khurana, Taruna AU - Osorio, Manuel AU - Lee, Gloria M AU - Kelly, Vanessa K AU - Stibitz, Scott AU - Merkel, Tod J AD - Laboratory of Respiratory and Special Pathogens. Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892 Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 255 EP - 265 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Bacilli KW - Anthrax lethal toxin KW - Aerosols KW - Deletion mutant KW - Data processing KW - Lung diseases KW - Animal models KW - Survival KW - Immunity KW - Bacillus anthracis KW - Infection KW - Lymphoid tissue KW - Lymph nodes KW - Virulence KW - Lung KW - Immunoglobulin G KW - Anthrax KW - Immune response KW - Spores KW - X 24370:Natural Toxins KW - A 01310:Products of Microorganisms KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20382514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Role+of+Anthrax+Toxins+in+Dissemination%2C+Disease+Progression%2C+and+Induction+of+Protective+Adaptive+Immunity+in+the+Mouse+Aerosol+Challenge+Model&rft.au=Loving%2C+Crystal+L%3BKhurana%2C+Taruna%3BOsorio%2C+Manuel%3BLee%2C+Gloria+M%3BKelly%2C+Vanessa+K%3BStibitz%2C+Scott%3BMerkel%2C+Tod+J&rft.aulast=Loving&rft.aufirst=Crystal&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; Bacilli; Aerosols; Data processing; Deletion mutant; Animal models; Lung diseases; Survival; Immunity; Infection; Lymph nodes; Lymphoid tissue; Virulence; Lung; Immunoglobulin G; Anthrax; Immune response; Spores; Bacillus anthracis ER - TY - JOUR T1 - Multiecho dixon fat and water separation method for detecting fibrofatty infiltration in the myocardium AN - 20373610; 9058293 AB - Conventional approaches for fat and water discrimination based on chemical-shift fat suppression have reduced ability to characterize fatty infiltration due to poor contrast of microscopic fat. The multiecho Dixon approach to water and fat separation has advantages over chemical-shift fat suppression: 1) water and fat images can be acquired in a single breathhold, avoiding misregistration; 2) fat has positive contrast; 3) the method is compatible with precontrast and late-enhancement imaging, 4) less susceptible to partial-volume effects, and 5) robust in the presence of background field variation; and 6) for the bandwidth implemented, chemical-shift artifact is decreased. The proposed technique was applied successfully in all 28 patients studied. This included 10 studies with indication of coronary artery disease (CAD), of which four cases with chronic myocardial infarction (MI) exhibited fatty infiltration; 13 studies to rule out arrhythmogenic right ventricular cardiomyopathy (ARVC), of which there were three cases with fibrofatty infiltration and two confirmed with ARVC; and five cases of cardiac masses (two lipomas). The precontrast contrast-to-noise ratio (CNR) of intramyocardial fat was greatly improved, by 240% relative to conventional fat suppression. For the parameters implemented, the signal-to-noise ratio (SNR) was decreased by 30% relative to conventional late enhancement. The multiecho Dixon method for fat and water separation provides a sensitive means of detecting intramyocardial fat with positive signal contrast. Magn Reson Med 61:215-221, 2009. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Hernando, Diego AU - Shah, Saurabh AU - Zuehlsdorff, Sven AU - Jerecic, Renate AU - Mancini, Christine AU - Liang, Zhi-Pei AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), U.S. Department of Health and Human Services (DHHS), Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 215 EP - 221 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 61 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Cardiomyopathy KW - Ventricle KW - N.M.R. KW - lipoma KW - imaging KW - Myocardial infarction KW - Heart diseases KW - Myocardium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Multiecho+dixon+fat+and+water+separation+method+for+detecting+fibrofatty+infiltration+in+the+myocardium&rft.au=Kellman%2C+Peter%3BHernando%2C+Diego%3BShah%2C+Saurabh%3BZuehlsdorff%2C+Sven%3BJerecic%2C+Renate%3BMancini%2C+Christine%3BLiang%2C+Zhi-Pei%3BArai%2C+Andrew+E&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2009-01-01&rft.volume=61&rft.issue=1&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21657 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Cardiomyopathy; Ventricle; N.M.R.; lipoma; imaging; Myocardial infarction; Myocardium; Heart diseases DO - http://dx.doi.org/10.1002/mrm.21657 ER - TY - JOUR T1 - Particulate matter and carbon dioxide in classrooms - The impact of cleaning and ventilation AN - 20369430; 9045171 AB - The objective of the study was to measure the indoor air quality in classrooms with special emphasis on particulate matter (PM 10) and carbon dioxide (CO2) and the impact of cleaning and ventilation. Material and method PM 10 was analysed via gravimetric method and by laser beam technology. CO2 was analysed by infrared sensors. Measurements were collected for 3 weeks; first week: 'normal' cleaning (twice a week) and ventilation; second week: intensified cleaning (five times a week); third week: intensified cleaning and intensified ventilation. Results Levels of PM 10 in the classrooms during the 3 weeks were 69±19 mg/m3 and they were dominated by occupancy and the persons' activity. Intensified cleaning showed a significant decrease in all classrooms (79±22 to 64±15 mg/m3). The effect of ventilation on levels of PM10 was inconsistent - levels of CO2 were very high in all schools and could be diminished by intensified ventilation (mean 1459 to 1051 ppm). Conclusion Although further investigation is needed to study detailed characteristics of the PM 10 (size distribution, chemical identity) the data are sufficient to improve the cleaning and the ventilation in schools. JF - International Journal of Hygiene and Environmental Health AU - Heudorf, U AU - Neitzert, V AU - Spark, J AD - Public Health Service of the City of Frankfurt/M., Braubachstr. 18-22, D-60311 Frankfurt, Germany, ursel.heudorf@stadt-frankfurt.de Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 45 EP - 55 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 212 IS - 1 SN - 1438-4639, 1438-4639 KW - Pollution Abstracts KW - Air quality KW - Schools KW - Particulate matter PM 10 KW - Carbon dioxide KW - Cleaning KW - Ventilation KW - schools KW - Sensors KW - Indoor air pollution KW - Lasers KW - Particulates KW - Technology KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20369430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Hygiene+and+Environmental+Health&rft.atitle=Particulate+matter+and+carbon+dioxide+in+classrooms+-+The+impact+of+cleaning+and+ventilation&rft.au=Heudorf%2C+U%3BNeitzert%2C+V%3BSpark%2C+J&rft.aulast=Heudorf&rft.aufirst=U&rft.date=2009-01-01&rft.volume=212&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Hygiene+and+Environmental+Health&rft.issn=14384639&rft_id=info:doi/10.1016%2Fj.ijheh.2007.09.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sensors; schools; Ventilation; Indoor air pollution; Lasers; Particulates; Carbon dioxide; Technology DO - http://dx.doi.org/10.1016/j.ijheh.2007.09.011 ER - TY - JOUR T1 - The National Center for Biotechnology Information's Protein Clusters Database AN - 20301425; 8921564 AB - Rapid increases in DNA sequencing capabilities have led to a vast increase in the data generated from prokaryotic genomic studies, which has been a boon to scientists studying micro-organism evolution and to those who wish to understand the biological underpinnings of microbial systems. The NCBI Protein Clusters Database (ProtClustDB) has been created to efficiently maintain and keep the deluge of data up to date. ProtClustDB contains both curated and uncurated clusters of proteins grouped by sequence similarity. The May 2008 release contains a total of 285 386 clusters derived from over 1.7 million proteins encoded by 3806 nt sequences from the RefSeq collection of complete chromosomes and plasmids from four major groups: prokaryotes, bacteriophages and the mitochondrial and chloroplast organelles. There are 7180 clusters containing 376 513 proteins with curated gene and protein functional annotation. PubMed identifiers and external cross references are collected for all clusters and provide additional information resources. A suite of web tools is available to explore more detailed information, such as multiple alignments, phylogenetic trees and genomic neighborhoods. ProtClustDB provides an efficient method to aggregate gene and protein annotation for researchers and is available at http://www.ncbi.nlm.nih.gov/sites/entrez?db=proteinclusters. JF - Nucleic Acids Research AU - Klimke, William AU - Agarwala, Richa AU - Badretdin, Azat AU - Chetvernin, Slava AU - Ciufo, Stacy AU - Fedorov, Boris AU - Kiryutin, Boris AU - O'Neill, Kathleen AU - Resch, Wolfgang AU - Resenchuk, Sergei AU - Schafer, Susan AU - Tolstoy, Igor AU - Tatusova, Tatiana AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA, klimke@ncbi.nlm.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - D216 EP - D223 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 37 IS - suppl_1 SN - 0305-1048, 0305-1048 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Phylogeny KW - Phages KW - Data processing KW - Mitochondria KW - Chloroplasts KW - Plasmids KW - Databases KW - DNA sequencing KW - Chromosomes KW - Prokaryotes KW - genomics KW - Organelles KW - Evolution KW - Amino acid sequence KW - V 22320:Replication KW - N 14810:Methods KW - G 07760:Viruses & Phages KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20301425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=The+National+Center+for+Biotechnology+Information%27s+Protein+Clusters+Database&rft.au=Klimke%2C+William%3BAgarwala%2C+Richa%3BBadretdin%2C+Azat%3BChetvernin%2C+Slava%3BCiufo%2C+Stacy%3BFedorov%2C+Boris%3BKiryutin%2C+Boris%3BO%27Neill%2C+Kathleen%3BResch%2C+Wolfgang%3BResenchuk%2C+Sergei%3BSchafer%2C+Susan%3BTolstoy%2C+Igor%3BTatusova%2C+Tatiana&rft.aulast=Klimke&rft.aufirst=William&rft.date=2009-01-01&rft.volume=37&rft.issue=suppl_1&rft.spage=D216&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn734 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phages; Phylogeny; Data processing; Mitochondria; Chloroplasts; Plasmids; Databases; Chromosomes; DNA sequencing; genomics; Prokaryotes; Organelles; Evolution; Amino acid sequence DO - http://dx.doi.org/10.1093/nar/gkn734 ER - TY - JOUR T1 - Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review AN - 20298955; 8917378 AB - BACKGROUND: Autologous plasma rich in platelets (PRP) is a derived blood product whose application in clinical practice is growing. A systematic review was conducted to evaluate its efficacy and safety.STUDY DESIGN AND METHODS: A search was performed in electronic databases. Randomized controlled clinical trials (RCTs) in adult patients were included and assessed for methodologic quality. The main outcomes were 'tissue regeneration' and 'safety.' Relative risks (RRs) and standardized mean differences (SMDs) were calculated to show pooled estimates for these outcomes. When the results heterogeneity was more than 50 percent, a sensitivity analysis was performed.RESULTS: Twenty RCTs were included (11 of oral and maxillofacial surgery, 7 of chronic skin ulcers, and 2 of surgery wounds). Four RCTs evaluated the depth reduction in gingival recession in chronic periodontitis; the SMD was 0.54 (95% confidence interval [CI], 0.16 to 0.92)mm, favorable to PRP. Three RCTs evaluated the clinical attachment level in chronic periodontitis; the SMD was 0.33 (95% CI, -0.71 to 1.37) mm. Six RCTs assessed the complete skin epithelialization in wound ulcers; the RR was 1.40 (95% CI, 0.85 to 2.31). Only 6 RCTs reported adverse effects without differences between groups.CONCLUSIONS: PRP improves the gingival recession but not the clinical attachment level in chronic periodontitis. In the complete healing process of chronic skin ulcers, the results are inconclusive. There are little data about PRP safety. There are several methodologic limitations and, consequently, future research should focus on strong and well-designed RCTs that assess the efficacy and safety of PRP. JF - Transfusion AU - Martinez-Zapata, Ma Jose AU - Marti-Carvajal, Arturo AU - Sola, Ivan AU - Bolibar, Ignasi AU - Angel Exposito, Jose AU - Rodriguez, Luciano AU - Garcia, Joan AD - From the Iberoamerican Cochrane Center, Epidemiology and Public Health Service, Hospital de la Santa Creu i Sant Pau, Barcelona; CIBER Epidemiologia y Salud Publica (CIBERESP); Universidad 'Arturo Michelena' and Iberoamerican Cochrane Collaboration Network, Valencia (Venezuela); and the Universitat Autonoma de Barcelona, Banc de Sang i Teixits de Catalunya, Barcelona, Spain. Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 44 EP - 56 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 49 SN - 0041-1132, 0041-1132 KW - Virology & AIDS Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Tissues KW - Maxilla KW - clinical trials KW - Clinical trials KW - surgery KW - sensitivity analysis KW - Surgery KW - Blood products KW - Data processing KW - Skin KW - regeneration KW - Gingiva KW - Wounds KW - Databases KW - safety engineering KW - Periodontitis KW - Ulcers KW - Reviews KW - Platelets KW - Standards KW - Face KW - Side effects KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20298955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Efficacy+and+safety+of+the+use+of+autologous+plasma+rich+in+platelets+for+tissue+regeneration%3A+a+systematic+review&rft.au=Martinez-Zapata%2C+Ma+Jose%3BMarti-Carvajal%2C+Arturo%3BSola%2C+Ivan%3BBolibar%2C+Ignasi%3BAngel+Exposito%2C+Jose%3BRodriguez%2C+Luciano%3BGarcia%2C+Joan&rft.aulast=Martinez-Zapata&rft.aufirst=Ma&rft.date=2009-01-01&rft.volume=49&rft.issue=&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2008.01945.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Blood products; Skin; Data processing; Maxilla; Gingiva; Clinical trials; Wounds; Databases; Ulcers; Periodontitis; Surgery; Platelets; Face; Side effects; Tissues; safety engineering; regeneration; sensitivity analysis; Reviews; Standards; clinical trials; surgery DO - http://dx.doi.org/10.1111/j.1537-2995.2008.01945.x ER - TY - JOUR T1 - Characterization of Salmonella enterica isolates from infants and toddlers in Wuhan, China AN - 20273732; 8921334 AB - Background Extended-spectrum cephalosporins and fluoroquinolones are important antimicrobials for treating invasive salmonellosis, and emerging resistance to these antimicrobials is of paramount concern. This study reports on the antimicrobial susceptibility and molecular characterization of Salmonella enterica isolates recovered in 2006 from 0- to 3-year-old outpatients in China.Methods The isolates were subjected to serotyping, antimicrobial susceptibility testing, screening for b-lactamase genes, mutations in the quinolone resistance determining regions (QRDRs), qnr alleles and aac-(6)-Ib-cr by PCR followed by DNA sequence analysis. All Salmonella Typhimurium isolates and 43 selected non-Typhimurium isolates were further characterized by PFGE to determine the genetic relatedness.Results From 3746 paediatric outpatient stool samples, 221 (5.9%) S. enterica isolates of 29 distinct serotypes were recovered. The antimicrobial resistance profiles differed among serotypes. Ciprofloxacin-resistant isolates were concentrated in serotype Typhimurium that were resistant to at least four additional non-quinolone antimicrobials. Nineteen out of 22 ciprofloxacin-resistant Salmonella Typhimurium isolates were grouped into one PFGE cluster. Plasmid-mediated quinolone resistance determinant aac-(6)-Ib-cr was detected in 18 S. enterica isolates and 4 isolates also carried qnr alleles. Plasmid-mediated blaCTX-M-14-like genes were found in seven ceftriaxone-resistant isolates, and two isolates also exhibited reduced susceptibility to ciprofloxacin.Conclusions Based on these results, fluoroquinolones should not be used to treat the invasive Salmonella Typhimurium infections in this local community. The monitoring programme should stay vigilant for ceftriaxone-resistant S. enterica isolates with reduced fluoroquinolone susceptibility. JF - Journal of Antimicrobial Chemotherapy AU - Cui, Shenghui AU - Li, Jingyun AU - Sun, Ziyong AU - Hu, Changqin AU - Jin, Shaohong AU - Li, Fengqin AU - Guo, Yunchang AU - Ran, Lu AU - Ma, Yue AD - 1 The National Center for Surveillance of Antimicrobial Resistance, The State Food and Drug Administration, Beijing , People's Republic of China, nicpbp@263.net Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 87 EP - 94 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 63 IS - 1 SN - 0305-7453, 0305-7453 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - quinolones KW - ESBLs KW - antimicrobial resistance KW - qnr KW - CTX-M KW - Cephalosporins KW - Serotypes KW - Fluoroquinolones KW - Pediatrics KW - Nucleotide sequence KW - Drug resistance KW - Quinolones KW - Serotyping KW - Salmonella typhimurium KW - Infection KW - Salmonella enterica KW - Salmonellosis KW - Polymerase chain reaction KW - b-Lactamase KW - Feces KW - Mutation KW - Infants KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20273732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Characterization+of+Salmonella+enterica+isolates+from+infants+and+toddlers+in+Wuhan%2C+China&rft.au=Cui%2C+Shenghui%3BLi%2C+Jingyun%3BSun%2C+Ziyong%3BHu%2C+Changqin%3BJin%2C+Shaohong%3BLi%2C+Fengqin%3BGuo%2C+Yunchang%3BRan%2C+Lu%3BMa%2C+Yue&rft.aulast=Cui&rft.aufirst=Shenghui&rft.date=2009-01-01&rft.volume=63&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkn452 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cephalosporins; Serotypes; Fluoroquinolones; Pediatrics; Drug resistance; Nucleotide sequence; Quinolones; Serotyping; Infection; Salmonellosis; Polymerase chain reaction; b-Lactamase; Feces; Mutation; Infants; Salmonella enterica; Salmonella typhimurium DO - http://dx.doi.org/10.1093/jac/dkn452 ER - TY - JOUR T1 - An investigation on characteristics of the vibration transmitted to wrist and elbow in the operation of impact wrenches AN - 20266131; 8865218 AB - To help assess the risk of the vibration exposure during impact wrench operation and to develop a convenient and effective method to monitor and control the exposure, this study aims to investigate the characteristics of the vibrations transmitted to the wrist and elbow in the operation and to evaluate the on-the-wrist and on-the-elbow vibration measurement methods. Six subjects participated in the experiment. Each of them used 15 impact wrenches on a simulated workstation. Tri-axial accelerations at three locations (tool handle, wrist, and elbow) and the tool effective torques were measured and used in the evaluations. Results confirm that the severity of the vibration exposure generally depends on tool and individual, and that the vibrations measured at wrist and elbow reflect the influences of both factors. This study also found that the accelerations measured at the wrist and elbow are correlated with the ISO frequency-weighted tool acceleration. The fundamental resonance of the hand-arm system in the range of 16-50 Hz is well reflected in the vibration measured at the wrist. The results also demonstrate that vibration exposure duration can be reliably detected from the wrist vibration data. Moreover, the wrist vibration is suggestively correlated with the torque of the pneumatic impact wrenches. These findings suggest that the measurement of the wrist vibration can be used as an alternative approach to perform the exposure risk assessment and to monitor and control the exposures in the operation of the impact wrenches. Relevance to Industry - Impact wrenches or nut runners with impact action are widely and intensively used in automobile manufacturing and repair, which could generate significant vibration and require forceful actions. Prolonged, intensive exposure to both vibration and forceful actions could result in hand-arm vibration syndrome and carpal tunnel syndrome. The results of this study suggest that the on- the-wrist vibration measurement is a reasonable alternative approach for quantifying and assessing the exposures, which provides a theoretical base for developing a convenient and effective method for monitoring and controlling the combined exposures. The results of this study also suggest that the on-the-wrist method can also be used at workplaces to perform screening tests of the tools with dominant vibration frequencies similar to those of the impact wrenches and to evaluate the effectiveness of the anti- vibration devices used with such tools. JF - International Journal of Industrial Ergonomics AU - Xu, X S AU - Welcome, DE AU - McDowell, T W AU - Warren, C AU - Dong, R G AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, xxu1@cdc.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 174 EP - 184 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 39 IS - 1 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Hand-arm vibration KW - Hand-transmitted vibration KW - Impact wrench KW - Nut runner KW - Wrist KW - Risk assessment KW - Vibration KW - Automotive industry KW - carpal tunnel syndrome KW - overuse injuries KW - hand-arm vibration syndrome KW - Ergonomics KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20266131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=An+investigation+on+characteristics+of+the+vibration+transmitted+to+wrist+and+elbow+in+the+operation+of+impact+wrenches&rft.au=Xu%2C+X+S%3BWelcome%2C+DE%3BMcDowell%2C+T+W%3BWarren%2C+C%3BDong%2C+R+G&rft.aulast=Xu&rft.aufirst=X&rft.date=2009-01-01&rft.volume=39&rft.issue=1&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2008.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Vibration; overuse injuries; carpal tunnel syndrome; Automotive industry; hand-arm vibration syndrome; Occupational exposure; Ergonomics DO - http://dx.doi.org/10.1016/j.ergon.2008.05.006 ER - TY - JOUR T1 - Survey of Heavy Metal Contents of Circulating Agricultural Products in Korea AN - 20218795; 10824115 AB - This survey was conducted as a surveillance program following the establishment of safety guidelines for agricultural products in Korea. Concentrations of arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg) were measured in 421 samples using a mercury analyzer or ICP-MS. The average levels of Pb in mg/kg were 0.021 for rice, 0.020 for corn, 0.028 for soybeans, 0.034 for red beans, 0.025 for sweet potatoes, 0.021 for potatoes, 0.019 for Chinese cabbage, 0.031 for spinach, 0.021 for Welsh onions, and 0.011 for radishes. The average levels of Cd in mg/kg were 0.021 for rice, 0.002 for corn, 0.020 for soybeans, 0.006 for red beans, 0.008 for sweet potatoes, 0.011 for potatoes, 0.007 for Chinese cabbage, 0.035 for spinach, 0.006 for Welsh onions, and, 0.006 for radishes. The average levels of As in mg/kg were 0.103 for rice, 0.005 for corn, 0.007 for soybeans, 0.005 for red beans, 0.005 for sweet potatoes, 0.004 for potatoes, 0.007 for Chinese cabbage, 0.015 for spinach, 0.009 for Welsh onions and, 0.006 for radishes. Finally, the average levels of Hg in mu g/kg were 2.3 for rice, 0.2 for corn, 0.6 for soybeans, 1.4 for red beans, 0.1 for sweet potatoes, 0.3 for potatoes, 0.5 Chinese cabbage, 2.1 for spinach, 0.5 for Welsh onions, and 0.2 for radishes. Based on the Korean public nutrition report 2005, these levels (or amounts) are calculated only at 2.6% for Pb, 8.7% for Cd, 1.2% for Hg of those presented in provisional tolerable weekly intake (PTWI) which has been established by FAO/WHO. Therefore, the levels presented here are presumed to be adequately safe. JF - Korean Journal of Food Science and Technology AU - Kim, H-Y AU - Kim, J-I AU - Kim, J-C AU - Park, J-E AU - Lee, K-J AU - Kim, S-I AU - Oh, J-H AU - Jang, Y-M AD - Imported Food Analysis division, Center for Food and Drug Analysis, Gyeongin Regional Korea Food and Drug Administration, jc2kim@korea.kr Y1 - 2009 PY - 2009 DA - 2009 SP - 238 EP - 244 VL - 41 IS - 3 SN - 0367-6293, 0367-6293 KW - Health & Safety Science Abstracts KW - Arsenic KW - Oryza sativa KW - Brassica KW - Nutrition KW - corn KW - Lead KW - guidelines KW - Solanum tuberosum KW - FAO KW - Allium cepa KW - Mercury KW - Korea, Rep. KW - Spinacia oleracea KW - soybeans KW - heavy metals KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20218795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Korean+Journal+of+Food+Science+and+Technology&rft.atitle=Survey+of+Heavy+Metal+Contents+of+Circulating+Agricultural+Products+in+Korea&rft.au=Kim%2C+H-Y%3BKim%2C+J-I%3BKim%2C+J-C%3BPark%2C+J-E%3BLee%2C+K-J%3BKim%2C+S-I%3BOh%2C+J-H%3BJang%2C+Y-M&rft.aulast=Kim&rft.aufirst=H-Y&rft.date=2009-01-01&rft.volume=41&rft.issue=3&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Korean+Journal+of+Food+Science+and+Technology&rft.issn=03676293&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Arsenic; guidelines; Mercury; Nutrition; heavy metals; Lead; soybeans; corn; Solanum tuberosum; Allium cepa; Oryza sativa; Spinacia oleracea; Brassica; FAO; Korea, Rep. ER - TY - JOUR T1 - Limitations of the Efficacy of Surface Disinfection in the Healthcare Setting AN - 20079758; 10190088 AB - We examined the efficacy of 2 commercially available wipes to effectively remove, kill, and prevent the transfer of both methicillin-resistant and methicillin-susceptible Staphylococcus aureus from contaminated surfaces. Although wipes play a role in decreasing the number of pathogenic bacteria from contaminated surfaces, they can potentially transfer bacteria to other surfaces if they are reused. JF - Infection Control and Hospital Epidemiology AU - Williams, Gareth J AU - Denyer, Stephen P AU - Hosein, Ian K AU - Hill, Dylan W AU - Maillard, Jean-Yves AD - Welsh School of Pharmacy, Cardiff University, the Infection Prevention and Control Department, Cardiff and Vale National Health Service Trust, and National Public Health Service Microbiology, Cardiff, Wales, williamsgj3@cf.ac.uk Y1 - 2009 PY - 2009 DA - 2009 SP - 570 EP - 573 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 30 IS - 6 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Disinfection KW - Drug resistance KW - Staphylococcus aureus KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20079758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Limitations+of+the+Efficacy+of+Surface+Disinfection+in+the+Healthcare+Setting&rft.au=Williams%2C+Gareth+J%3BDenyer%2C+Stephen+P%3BHosein%2C+Ian+K%3BHill%2C+Dylan+W%3BMaillard%2C+Jean-Yves&rft.aulast=Williams&rft.aufirst=Gareth&rft.date=2009-01-01&rft.volume=30&rft.issue=6&rft.spage=570&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F597382 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Disinfection; Drug resistance; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1086/597382 ER - TY - JOUR T1 - Measurements of Ultrasonic Backscattered Spectral Centroid Shift From Spine In Vivo: Methodology and Preliminary Results AN - 19722043; 9067933 AB - Ultrasonic backscatter measurements from vertebral bodies (L3 and L4) in nine women were performed using a clinical ultrasonic imaging system. Measurements were made through the abdomen. The location of a vertebra was identified from the bright specular reflection from the vertebral anterior surface. Backscattered signals were gated to isolate signal emanating from the cancellous interiors of vertebrae. The spectral centroid shift of the backscattered signal, which has previously been shown to correlate highly with bone mineral density (BMD) in human calcaneus in vitro, was measured. BMD was also measured in the nine subjects' vertebrae using a clinical bone densitometer. The correlation coefficient between centroid shift and BMD was r = -0.61. The slope of the linear fit was -160 kHz / (g/cm2). The negative slope was expected because the attenuation coefficient (and therefore magnitude of the centroid downshift) is known from previous studies to increase with BMD. The centroid shift may be a useful parameter for characterizing bone in vivo. JF - Ultrasound in Medicine & Biology AU - Garra, Brian S AU - Locher, Melanie AU - Felker, Steven AU - Wear, Keith A AD - US Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD, USA, keith.wear@fda.hhs.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 165 EP - 168 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 35 IS - 1 SN - 0301-5629, 0301-5629 KW - Biotechnology and Bioengineering Abstracts KW - Calcaneus KW - Spine KW - Bone mineral density KW - Abdomen KW - imaging KW - Ultrasound KW - Vertebrae KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19722043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Measurements+of+Ultrasonic+Backscattered+Spectral+Centroid+Shift+From+Spine+In+Vivo%3A+Methodology+and+Preliminary+Results&rft.au=Garra%2C+Brian+S%3BLocher%2C+Melanie%3BFelker%2C+Steven%3BWear%2C+Keith+A&rft.aulast=Garra&rft.aufirst=Brian&rft.date=2009-01-01&rft.volume=35&rft.issue=1&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2008.06.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Bone mineral density; Vertebrae; Spine; Ultrasound; Calcaneus; imaging; Abdomen DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2008.06.004 ER -